WorldWideScience

Sample records for reservation signaling design

  1. [Signal Processing Suite Design

    Science.gov (United States)

    Sahr, John D.; Mir, Hasan; Morabito, Andrew; Grossman, Matthew

    2003-01-01

    Our role in this project was to participate in the design of the signal processing suite to analyze plasma density measurements on board a small constellation (3 or 4) satellites in Low Earth Orbit. As we are new to space craft experiments, one of the challenges was to simply gain understanding of the quantity of data which would flow from the satellites, and possibly to interact with the design teams in generating optimal sampling patterns. For example, as the fleet of satellites were intended to fly through the same volume of space (displaced slightly in time and space), the bulk plasma structure should be common among the spacecraft. Therefore, an optimal, limited bandwidth data downlink would take advantage of this commonality. Also, motivated by techniques in ionospheric radar, we hoped to investigate the possibility of employing aperiodic sampling in order to gain access to a wider spatial spectrum without suffering aliasing in k-space.

  2. Measuring signal generators theory & design

    CERN Document Server

    Rybin, Yuriy K

    2014-01-01

    The book brings together the following issues: Theory of deterministic, random and discrete signals reproducible in oscillatory systems of generators; Generation of periodic signals with a specified spectrum, harmonic distortion factor and random signals with specified probability density function and spectral density; Synthesis of oscillatory system structures; Analysis of oscillatory systems with non-linear elements and oscillation amplitude stabilization systems; It considers the conditions and criteria of steady-state modes in signal generators on active four-pole elements with unidirectional and bidirectional transmission of signals and on two-pole elements; analogues of Barkhausen criteria; Optimization of oscillatory system structures by harmonic distortion level, minimization of a frequency error and set-up time of the steady state mode; Theory of construction of random signal generators; Construction of discrete and digital signal generators; Practical design of main units of generators; Practical bl...

  3. Small signal microwave amplifier design

    CERN Document Server

    Grosch, Theodore

    2000-01-01

    This book explains techniques and examples for designing stable amplifiers for high-frequency applications in which the signal is small and the amplifier circuit is linear. An in-depth discussion of linear network theory provides the foundation needed to develop actual designs. Examples throughout the book will show you how to apply the knowledge gained in each chapter leading to the complex design of low noise amplifiers. Many exercises at the end of each chapter will help students to practice their skills. The solutions to these design problems are available in an accompanying solutions book

  4. Designer cell signal processing circuits for biotechnology.

    Science.gov (United States)

    Bradley, Robert W; Wang, Baojun

    2015-12-25

    Microorganisms are able to respond effectively to diverse signals from their environment and internal metabolism owing to their inherent sophisticated information processing capacity. A central aim of synthetic biology is to control and reprogramme the signal processing pathways within living cells so as to realise repurposed, beneficial applications ranging from disease diagnosis and environmental sensing to chemical bioproduction. To date most examples of synthetic biological signal processing have been built based on digital information flow, though analogue computing is being developed to cope with more complex operations and larger sets of variables. Great progress has been made in expanding the categories of characterised biological components that can be used for cellular signal manipulation, thereby allowing synthetic biologists to more rationally programme increasingly complex behaviours into living cells. Here we present a current overview of the components and strategies that exist for designer cell signal processing and decision making, discuss how these have been implemented in prototype systems for therapeutic, environmental, and industrial biotechnological applications, and examine emerging challenges in this promising field. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  5. Designing connected marine reserves in the face of global warming.

    Science.gov (United States)

    Álvarez-Romero, Jorge G; Munguía-Vega, Adrián; Beger, Maria; Del Mar Mancha-Cisneros, Maria; Suárez-Castillo, Alvin N; Gurney, Georgina G; Pressey, Robert L; Gerber, Leah R; Morzaria-Luna, Hem Nalini; Reyes-Bonilla, Héctor; Adams, Vanessa M; Kolb, Melanie; Graham, Erin M; VanDerWal, Jeremy; Castillo-López, Alejandro; Hinojosa-Arango, Gustavo; Petatán-Ramírez, David; Moreno-Baez, Marcia; Godínez-Reyes, Carlos R; Torre, Jorge

    2018-02-01

    Marine reserves are widely used to protect species important for conservation and fisheries and to help maintain ecological processes that sustain their populations, including recruitment and dispersal. Achieving these goals requires well-connected networks of marine reserves that maximize larval connectivity, thus allowing exchanges between populations and recolonization after local disturbances. However, global warming can disrupt connectivity by shortening potential dispersal pathways through changes in larval physiology. These changes can compromise the performance of marine reserve networks, thus requiring adjusting their design to account for ocean warming. To date, empirical approaches to marine prioritization have not considered larval connectivity as affected by global warming. Here, we develop a framework for designing marine reserve networks that integrates graph theory and changes in larval connectivity due to potential reductions in planktonic larval duration (PLD) associated with ocean warming, given current socioeconomic constraints. Using the Gulf of California as case study, we assess the benefits and costs of adjusting networks to account for connectivity, with and without ocean warming. We compare reserve networks designed to achieve representation of species and ecosystems with networks designed to also maximize connectivity under current and future ocean-warming scenarios. Our results indicate that current larval connectivity could be reduced significantly under ocean warming because of shortened PLDs. Given the potential changes in connectivity, we show that our graph-theoretical approach based on centrality (eigenvector and distance-weighted fragmentation) of habitat patches can help design better-connected marine reserve networks for the future with equivalent costs. We found that maintaining dispersal connectivity incidentally through representation-only reserve design is unlikely, particularly in regions with strong asymmetric patterns of

  6. The principle of complementarity in the design of reserve networks ...

    Indian Academy of Sciences (India)

    Unknown

    Explicit, quantitative procedures for identifying biodiversity priority areas are replacing the often ad hoc procedures used in the past to design networks of reserves to conserve biodiversity. This change facilitates more informed choices by policy makers, and thereby makes possible greater satisfaction of conservation goals ...

  7. Signal conditioning circuitry design for instrumentation systems.

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, Cory A.

    2012-01-01

    This report details the current progress in the design, implementation, and validation of the signal conditioning circuitry used in a measurement instrumentation system. The purpose of this text is to document the current progress of a particular design in signal conditioning circuitry in an instrumentation system. The input of the signal conditioning circuitry comes from a piezoresistive transducer and the output will be fed to a 250 ksps, 12-bit analog-to-digital converter (ADC) with an input range of 0-5 V. It is assumed that the maximum differential voltage amplitude input from the sensor is 20 mV with an unknown, but presumably high, sensor bandwidth. This text focuses on a specific design; however, the theory is presented in such a way that this text can be used as a basis for future designs.

  8. White light signal simulator microcontroller design | Haghighi ...

    African Journals Online (AJOL)

    In this research, first through experimental studies, the recorded signals associated with the light white from human retina cells were digitized, then the digital data were calculated and the resulted mathematical equation was programmed on a microcontroller, and by designing a circuit, the output voltage over time similar to ...

  9. Integer programming methods for reserve selection and design

    Science.gov (United States)

    Robert G. Haight; Stephanie A. Snyder

    2009-01-01

    How many nature reserves should there be? Where should they be located? Which places have highest priority for protection? Conservation biologists, economists, and operations researchers have been developing quantitative methods to address these questions since the 1980s.

  10. [Signaling network-based functional cell design].

    Science.gov (United States)

    Ju, Jianqi; Wei, Ping

    2017-03-25

    Cellular signaling networks act as the central processor to deal with environmental signals and regulate cell function, and determine cell fate. Using synthetic biology approach to engineer cell signaling networks is crucial for ultimately constructing man-made "cell machines". Cellular signaling networks can encode sophisticated cell information by processing quantitatively signaling dynamics, which enables multi-dimensional regulation of functional sub-circuits. Here, we first review the research progresses on the signaling coding mechanisms; and then elaborate the methodologies and applications of cells signaling engineering; finally, we envision that signaling-based cell engineering are important for the increasingly-complicated next generation synthetic biology.

  11. The principle of complementarity in the design of reserve networks ...

    Indian Academy of Sciences (India)

    Unknown

    Ratcliffe envisioned a three-stage selection process: (i) field surveys, (ii) the application of explicitly agreed ..... equal. This leads to the creation of larger reserves. The. MNP algorithm has been the basis for many of the ...... It is a matter of judgement whether money is better spent on acquiring data or on land purchase based.

  12. A Reservation Aggregation Framework Design for Demand Estimation

    Directory of Open Access Journals (Sweden)

    T. Vítek

    2006-01-01

    Full Text Available Effective management practices in the tourism and hotel area have seldom been more important than at the present time. Pricing decisions cannot be taken without serious thought. IT has provided the opportunity for a customer to make a quick market search and it offers decision support systems that can be used in the hotel management. The heart of yield management system consists of the predicting machine, which estimates the number of incoming reservations. Incoming reservations arrive randomly in time. The time series calculi as well as the estimators known from control engineering require properly defined time rows (with a constant period. This requirement is usually not fulfilled, so the input data are not exploited properly. This paper outlines a procedure that aggregates the reservations into a time series that is useful for demand prediction. The algorithm prepares the data systematically for further processing. Any method that process time rows can be used for subsequent prediction: time series, linear models or time extrapolation. 

  13. Optimization of reserve lithium thionyl chloride battery electrochemical design parameters

    Energy Technology Data Exchange (ETDEWEB)

    Doddapaneni, N.; Godshall, N.A.

    1987-01-01

    The performance of Reserve Lithium Thionyl Chloride (RLTC) batteries was optimized by conducting a parametric study of seven electrochemical parameters: electrode compression, carbon thickness, presence of catalyst, temperature, electrode limitation, discharge rate, and electrolyte acidity. Increasing electrode compression (from 0 to 15%) improved battery performance significantly (10% greater carbon capacity density). Although thinner carbon cathodes yielded less absolute capacity than did thicker cathodes, they did so with considerably higher volume efficiencies. The effect of these parameters, and their synergistic interactions, on electrochemical cell peformance is illustrated. 5 refs., 9 figs., 3 tabs.

  14. Optimization of reserve lithium thionyl chloride battery electrochemical design parameters

    Science.gov (United States)

    Doddapaneni, N.; Godshall, N. A.

    The performance of Reserve Lithium Thionyl Chloride (RLTC) batteries was optimized by conducting a parametric study of seven electrochemical parameters: electrode compression, carbon thickness, presence of catalyst, temperature, electrode limitation, discharge rate, and electrolyte acidity. Increasing electrode compression (from 0 to 15 percent) improved battery performance significantly (10 percent greater carbon capacity density). Although thinner carbon cathodes yielded less absolute capacity than did thicker cathodes, they did so with considerably higher volume efficiencies. The effect of these parameters, and their synergistic interactions, on electrochemical cell performance is illustrated.

  15. Designing microcapsule arrays that propagate chemical signals

    Science.gov (United States)

    Bhattacharya, Amitabh; Balazs, Anna C.

    2010-08-01

    Using analysis and simulation, we show how ordered arrays of microcapsules in solution can be harnessed to propagate chemical signals in directed and controllable ways, allowing the signals to be transmitted over macroscopic distances. The system encompasses two types of capsules that are localized on an adhesive surface. The “signaling” capsules release inducer molecules, which trigger “targets” to release nanoparticles. The released nanoparticles can bind to the underlying surface and thus, create adhesion gradients, which then propel the signaling capsules to shuttle between neighboring targets. This arrangement acts like a relay, so that triggering target capsules at a particular location in the array also triggers target capsules in adjacent locations. For an array containing two target columns, our simulations and analysis show that steady input signal leads to a sustained periodic output. For an array containing multiple target columns, we show that by introducing a prescribed ratio of nanoparticle release rates between successive target columns, a chemical signal can be propagated along the array without dissipation. We also demonstrate that similar signal transmission cannot be performed via diffusion alone.

  16. Auditory signal design for automatic number plate recognition system

    NARCIS (Netherlands)

    Heydra, C.G.; Jansen, R.J.; Van Egmond, R.

    2014-01-01

    This paper focuses on the design of an auditory signal for the Automatic Number Plate Recognition system of Dutch national police. The auditory signal is designed to alert police officers of suspicious cars in their proximity, communicating priority level and location of the suspicious car and

  17. 10 CFR 433.6 - Sustainable principles for siting, design and construction. [Reserved

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Sustainable principles for siting, design and construction. [Reserved] 433.6 Section 433.6 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY STANDARDS... BUILDINGS § 433.6 Sustainable principles for siting, design and construction. [Reserved] ...

  18. Designer small molecules to target calcium signalling.

    Science.gov (United States)

    Swarbrick, Joanna M; Riley, Andrew M; Mills, Stephen J; Potter, Barry V L

    2015-06-01

    Synthetic compounds open up new avenues to interrogate and manipulate intracellular Ca2+ signalling pathways. They may ultimately lead to drug-like analogues to intervene in disease. Recent advances in chemical biology tools available to probe Ca2+ signalling are described, with a particular focus on those synthetic analogues from our group that have enhanced biological understanding or represent a step towards more drug-like molecules. Adenophostin (AdA) is the most potent known agonist at the inositol 1,4,5-trisphosphate receptor (IP3R) and synthetic analogues provide a binding model for receptor activation and channel opening. 2-O-Modified inositol 1,4,5-trisphosphate (IP3) derivatives that are partial agonists at the IP3R reveal key conformational changes of the receptor upon ligand binding. Biphenyl polyphosphates illustrate that simple non-inositol surrogates can be engineered to give prototype IP3R agonists or antagonists and act as templates for protein co-crystallization. Cyclic adenosine 5'-diphosphoribose (cADPR) can be selectively modified using total synthesis, generating chemically and biologically stable tools to investigate Ca2+ release via the ryanodine receptor (RyR) and to interfere with cADPR synthesis and degradation. The first neutral analogues with a synthetic pyrophosphate bioisostere surprisingly retain the ability to release Ca2+, suggesting a new route to membrane-permeant tools. Adenosine 5'-diphosphoribose (ADPR) activates the Ca2+-, Na+- and K+-permeable transient receptor potential melastatin 2 (TRPM2) cation channel. Synthetic ADPR analogues provide the first structure-activity relationship (SAR) for this emerging messenger and the first functional antagonists. An analogue based on the nicotinic acid motif of nicotinic acid adenine dinucleotide phosphate (NAADP) antagonizes NAADP-mediated Ca2+ release in vitro and is effective in vivo against induced heart arrhythmia and autoimmune disease, illustrating the therapeutic potential of

  19. Radar signal design problem with neural network processing

    Indian Academy of Sciences (India)

    Unknown

    Abstract. Binary and ternary sequences with peaky autocorrelation, measured in terms of high discrimination and merit factor have been searched earlier, using optimization techniques. It is shown that the use of neural network processing of the return signal is much more advantageous. It opens up a new signal design ...

  20. The design of virtual signal analyzer with high cost performance

    Science.gov (United States)

    Wang, Ya-nan; Pei, Gui-ling; Xu, Lei

    2013-03-01

    Based on 16bit STEREO AUDIO CODEC and C# this paper introduces a virtual signal analyzer. It mainly describes the system's overall structure, hardware design, PC software framework, etc. With reducing costs dramatically, the system also achieves being a signal generator, oscilloscope, recorder, spectrum analyzer, time-frequency analyzer and so on.

  1. Analysis of Design of Mixed-Signal Electronic Packaging

    National Research Council Canada - National Science Library

    Pileggi, Lawrence

    1999-01-01

    The objective of this project is to develop innovative algorithms and prototype tools that will help facilitate the design of mixed signal multi-chip modules and packaging in a manner that is similar...

  2. National monetary policy by regional design: the evolving role of the Federal Reserve banks in Federal Reserve System policy

    OpenAIRE

    David C. Wheelock

    1999-01-01

    This paper examines the history of Federal Reserve Bank input into Federal Reserve System monetary policymaking. From the Fed's founding in 1914 through the Great Depression, the Reserve Banks held the balance of power. Dissatisfaction with the Fed's performance, however, led to a wholesale reorganization in 1935 that greatly enhanced the authority of the Federal Reserve Board, but retained a role for the Federal Banks through the membership of their presidents on the FOMC, as well as in sett...

  3. Foundations of digital signal processing theory, algorithms and hardware design

    CERN Document Server

    Gaydecki, Patrick

    2005-01-01

    An excellent introductory text, this book covers the basic theoretical, algorithmic and real-time aspects of digital signal processing (DSP). Detailed information is provided on off-line, real-time and DSP programming and the reader is effortlessly guided through advanced topics such as DSP hardware design, FIR and IIR filter design and difference equation manipulation.

  4. Design of new multi-channel electrodes for surface electromyography signals for signal-processing.

    Science.gov (United States)

    Kilby, J; Prasad, K; Mawston, G

    2016-08-01

    This paper covers the design aspects of a new multi-channel electrode for the acquisition of surface electromyography signals from a selected muscle. The new multi-channel electrode has 11 pins where the monopolar signals produced will be configured in a software either as Linear array or Laplacian configuration. The design specification of the pre-amplifier ideally was to have a voltage gain of 500 with bandpass filtering of 5 Hz-1 kHz. The final design of the pre-amplifier circuit using an INA 118 instrumentation amplifier was built and tested to give values for voltage gain of 484 with bandpass filtering of 6.8 Hz-1.02 kHz. The software configuration that gives clearer and more defined signals in terms of motor unit action potentials for future signal processing is the Laplacian rather than Linear array.

  5. Gaussian Pulse-Based Two-Threshold Parallel Scaling Tone Reservation for PAPR Reduction of OFDM Signals

    Directory of Open Access Journals (Sweden)

    Lei Guan

    2011-01-01

    Full Text Available Tone Reservation (TR is a technique proposed to combat the high Peak-to-Average Power Ratio (PAPR problem of Orthogonal Frequency Division Multiplexing (OFDM signals. However conventional TR suffers from high computational cost due to the difficulties in finding an effective cancellation signal in the time domain by using only a few tones in the frequency domain. It also suffers from a high cost of hardware implementation and long handling time delay issues due to the need to conduct multiple iterations to cancel multiple high signal peaks. In this paper, we propose an efficient approach, called two-threshold parallel scaling, for implementing a previously proposed Gaussian pulse-based Tone Reservation algorithm. Compared to conventional approaches, this technique significantly reduces the hardware implementation complexity and cost, while also reducing signal processing time delay by using just two iterations. Experimental results show that the proposed technique can effectively reduce the PAPR of OFDM signals with only a very small number of reserved tones and with limited usage of hardware resources. This technique is suitable for any OFDM-based communication systems, especially for Digital Video Broadcasting (DVB systems employing large IFFT/FFT transforms.

  6. 10 CFR 435.6 - Sustainable principles for siting, design and construction. [Reserved

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Sustainable principles for siting, design and construction. [Reserved] 435.6 Section 435.6 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY STANDARDS...-Rise Residential Buildings. § 435.6 Sustainable principles for siting, design and construction...

  7. Development of knowledgebase system for assisting signal validation scheme design

    International Nuclear Information System (INIS)

    Kitamura, M.; Baba, T.; Washio, T.; Sugiyama, K.

    1987-01-01

    The purpose of this study is to develop a knowledgebase system to be used as a tool for designing signal validation schemes. The outputs from the signal validation scheme can be used as; (1) auxiliary signals for detecting sensor failures, (2) inputs to advanced instrumentation such as disturbance analysis and diagnosis system or safety parameter display system, and (3) inputs to digital control systems. Conventional signal validation techniques such as comparison of redundant sensors, limit checking, and calibration tests have been employed in nuclear power plants. However, these techniques have serious drawbacks, e.g. needs for extra sensors, vulnerability to common mode failures, limited applicability to continuous monitoring, etc. To alleviate these difficulties, a new signal validation technique has been developed by using the methods called analytic redundancy and parity space. Although the new technique has been proved feasible as far as preliminary tests are concerned, further developments should be made in order to enhance its practical applicability

  8. Design and Characteristic Analysis of Multicarrier Chaotic Phase Coded Radar Pulse Train Signal

    Directory of Open Access Journals (Sweden)

    Qiongdan Huang

    2014-01-01

    Full Text Available By introducing phase code into multicarrier orthogonal frequency division multiplex signal, the multicarrier phase coded (MCPC radar signal possesses a good spectrum utilization rate and can achieve a good combination of narrowband and wideband processing. Radar pulse train signal not only reserves the high range resolution of monopulse signal, but also has the same velocity resolution performance as continuous wave signal does. In this study, we use the chaotic biphase code generated by Chebyshev mapping to conduct a phase modulation on MCPC pulse train so as to design two different types of multicarrier chaotic phase coded pulse train signal. The ambiguity functions of the two pulse train signals are compared with that of P4 code MCPC pulse train. In addition, we analyze the influences of subcarrier number, phase-modulated bit number, and period number on the pulse train’s autocorrelation performance. The low probability of intercept (LPI performance of the two signals is also discussed. Simulation results show that the designed pulse train signals have a thumbtack ambiguity function, a periodic autocorrelation side lobe lower than P4 code MCPC pulse train, and excellent LPI performance, as well as the feature of waveform diversity.

  9. Design and implementation of a multiband digital filter using FPGA to extract the ECG signal in the presence of different interference signals.

    Science.gov (United States)

    Aboutabikh, Kamal; Aboukerdah, Nader

    2015-07-01

    In this paper, we propose a practical way to synthesize and filter an ECG signal in the presence of four types of interference signals: (1) those arising from power networks with a fundamental frequency of 50Hz, (2) those arising from respiration, having a frequency range from 0.05 to 0.5Hz, (3) muscle signals with a frequency of 25Hz, and (4) white noise present within the ECG signal band. This was done by implementing a multiband digital filter (seven bands) of type FIR Multiband Least Squares using a digital programmable device (Cyclone II EP2C70F896C6 FPGA, Altera), which was placed on an education and development board (DE2-70, Terasic). This filter was designed using the VHDL language in the Quartus II 9.1 design environment. The proposed method depends on Direct Digital Frequency Synthesizers (DDFS) designed to synthesize the ECG signal and various interference signals. So that the synthetic ECG specifications would be closer to actual ECG signals after filtering, we designed in a single multiband digital filter instead of using three separate digital filters LPF, HPF, BSF. Thus all interference signals were removed with a single digital filter. The multiband digital filter results were studied using a digital oscilloscope to characterize input and output signals in the presence of differing sinusoidal interference signals and white noise. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Designing sour taste signal micro-controller simulator | Haghighi ...

    African Journals Online (AJOL)

    In this paper, empirical studies on taste cells and the results of potential changes related to sour taste are used, and by studying the messages transmitted by the nervous system and equivalent sample signal of this taste, mathematical equations related to these changes are obtained, and by designing a microcontroller ...

  11. Bi-alphabetic pulse compression radar signal design

    Indian Academy of Sciences (India)

    Bi-alphabetic pulse compression radar signal design. I A PASHA1, P S MOHARIR2 AND N SUDARSHAN RAO3. 1Shadan College of Engineering & Technology, Hyderabad 500 008, India. 2National Geophysical Research Institute, Hyderabad 500 007, India. 3Department of Electrical Communication Engineering, ...

  12. Fluorescence signalling of the transition metal ions: Design strategy ...

    Indian Academy of Sciences (India)

    Unknown

    Abstract. Transition metal ions are notorious for their fluorescence quenching abilities. In this paper, we discuss the design strategies for the development of efficient off-on fluorescence signalling systems for the transition metal ions. It is shown that even simple fluorophore-spacer-receptor systems can display excellent.

  13. Wireless receiver architectures and design antennas, RF, synthesizers, mixed signal, and digital signal processing

    CERN Document Server

    Rouphael, Tony J

    2014-01-01

    Wireless Receiver Architectures and Design presents the various designs and architectures of wireless receivers in the context of modern multi-mode and multi-standard devices. This one-stop reference and guide to designing low-cost low-power multi-mode, multi-standard receivers treats analog and digital signal processing simultaneously, with equal detail given to the chosen architecture and modulating waveform. It provides a complete understanding of the receiver's analog front end and the digital backend, and how each affects the other. The book explains the design process in great detail, s

  14. 75 FR 66271 - Assessment Dividends, Assessment Rates and Designated Reserve Ratio

    Science.gov (United States)

    2010-10-27

    ... financial performance of IDIs has shown signs of improvement. The industry reported aggregate net income of... Part VI Federal Deposit Insurance Corporation 12 CFR Part 327 Assessment Dividends, Assessment... Assessment Dividends, Assessment Rates and Designated Reserve Ratio AGENCY: Federal Deposit Insurance...

  15. Redefining thermal regimes to design reserves for coral reefs in the face of climate change.

    Directory of Open Access Journals (Sweden)

    Iliana Chollett

    Full Text Available Reef managers cannot fight global warming through mitigation at local scale, but they can use information on thermal patterns to plan for reserve networks that maximize the probability of persistence of their reef system. Here we assess previous methods for the design of reserves for climate change and present a new approach to prioritize areas for conservation that leverages the most desirable properties of previous approaches. The new method moves the science of reserve design for climate change a step forwards by: (1 recognizing the role of seasonal acclimation in increasing the limits of environmental tolerance of corals and ameliorating the bleaching response; (2 using the best proxy for acclimatization currently available; (3 including information from several bleaching events, which frequency is likely to increase in the future; (4 assessing relevant variability at country scales, where most management plans are carried out. We demonstrate the method in Honduras, where a reassessment of the marine spatial plan is in progress.

  16. Optimal Spatial Matrix Filter Design for Array Signal Preprocessing

    Directory of Open Access Journals (Sweden)

    Haiyong Zhang

    2014-01-01

    Full Text Available An efficient technique of designing spatial matrix filter for array signal preprocessing based on convex programming was proposed. Five methods were considered for designing the filter. In design method 1, we minimized the passband fidelity subject to the controlled overall stopband attenuation level. In design method 2, the objective function and the constraint in the design method 1 were reversed. In design method 3, the optimal matrix filter which has the general mean square error was considered. In design method 4, the left stopband and the right stopband were constrained with specific attenuation level each, and the minimized passband fidelity was received. In design method 5, the optimization objective function was the sum of the left stopband and the right stopband attenuation levels with the weighting factors 1 and γ, respectively, and the passband fidelity was the constraints. The optimal solution of the optimizations above was derived by the Lagrange multiplier theory. The relations between the optimal solutions were analyzed. The generalized singular value decomposition was introduced to simplify the optimal solution of design methods 1 and 2 and enhanced the efficiency of solving the Lagrange multipliers. By simulations, it could be found that the proposed method was effective for designing the spatial matrix filter.

  17. Distortions in processed signals and their application in electronic design - III: An automated generator of communication jamming signals

    International Nuclear Information System (INIS)

    Njau, E.C.

    1987-10-01

    We describe the design and operational features of a simple electronic circuit that is capable of automatically generating a narrow bandwidth jamming signal around each frequency signal received from target transmitters. It is noted that jamming based upon this circuit is fairly difficult to nullify using some of the conventional ''counter jamming'' strategies since in this case the jamming signals are flexibly locked onto the spectral components of the received signals. (author). 3 refs, 3 figs

  18. Mixed-signal methodology guide advanced methodology for AMS IP and SOC design, verification and implementation

    CERN Document Server

    Chen, Jess; Mar, Monte F; Nizic, Mladen; Bailey, Brian

    2012-01-01

    This Book, The Mixed-Signal Methodology Guide: Advanced Methodology For Ams Ip And Soc Design, Verification, And Implementation Provides A Broad Overview Of The Design, Verification And Implementation Methodologies Required For Today's Mixed-Signal Designs. The Book Covers Mixed-Signal Design Trends And Challenges, Abstraction Of Analog Using Behavioral Models, Assertion-Based Metric-Driven Verification Methodology Applied On Analog And Mixed-Signal And Verification Of Low Power Intent In Mixed-Signal Design. It Also Describes Methodology For Physical Implementation In Context Of Concurrent Mixed-Signal Design And For Handling Advanced Node Physical Effects. The Book Contains Many Practical Examples Of Models And Techniques. The Authors Believe It Should Serve As A Reference To Many Analog, Digital And Mixed-Signal Designers, Verification, Physical Implementation Engineers And Managers In Their Pursuit Of Information For A Better Methodology Required To Address The Challenges Of Modern Mixed-Signal Design.

  19. Evolutionary design optimization of traffic signals applied to Quito city.

    Science.gov (United States)

    Armas, Rolando; Aguirre, Hernán; Daolio, Fabio; Tanaka, Kiyoshi

    2017-01-01

    This work applies evolutionary computation and machine learning methods to study the transportation system of Quito from a design optimization perspective. It couples an evolutionary algorithm with a microscopic transport simulator and uses the outcome of the optimization process to deepen our understanding of the problem and gain knowledge about the system. The work focuses on the optimization of a large number of traffic lights deployed on a wide area of the city and studies their impact on travel time, emissions and fuel consumption. An evolutionary algorithm with specialized mutation operators is proposed to search effectively in large decision spaces, evolving small populations for a short number of generations. The effects of the operators combined with a varying mutation schedule are studied, and an analysis of the parameters of the algorithm is also included. In addition, hierarchical clustering is performed on the best solutions found in several runs of the algorithm. An analysis of signal clusters and their geolocation, estimation of fuel consumption, spatial analysis of emissions, and an analysis of signal coordination provide an overall picture of the systemic effects of the optimization process.

  20. Evolutionary design optimization of traffic signals applied to Quito city.

    Directory of Open Access Journals (Sweden)

    Rolando Armas

    Full Text Available This work applies evolutionary computation and machine learning methods to study the transportation system of Quito from a design optimization perspective. It couples an evolutionary algorithm with a microscopic transport simulator and uses the outcome of the optimization process to deepen our understanding of the problem and gain knowledge about the system. The work focuses on the optimization of a large number of traffic lights deployed on a wide area of the city and studies their impact on travel time, emissions and fuel consumption. An evolutionary algorithm with specialized mutation operators is proposed to search effectively in large decision spaces, evolving small populations for a short number of generations. The effects of the operators combined with a varying mutation schedule are studied, and an analysis of the parameters of the algorithm is also included. In addition, hierarchical clustering is performed on the best solutions found in several runs of the algorithm. An analysis of signal clusters and their geolocation, estimation of fuel consumption, spatial analysis of emissions, and an analysis of signal coordination provide an overall picture of the systemic effects of the optimization process.

  1. Dynamic reserve design in the face of climate change and urbanization

    Science.gov (United States)

    Romañach, Stephanie; Johnson, Fred A.; Stith, Bradley M.; Bonneau, Mathieu

    2015-01-01

    Reserve design is a process that must address many ecological, social, and political factors to successfully identify parcels of land in need of protection to sustain wildlife populations and other natural resources. Making land acquisition choices for a large, terrestrial protected area is difficult because it occurs over a long timeframe and may involve consideration future conditions such as climate and urbanization changes. Decision makers need to consider factors including: order of parcel purchasing given budget constraints, future uncertainty, potential future landscape‐scale changes from urbanization and climate. In central Florida, two new refuges and the expansion of a third refuge are in various stages of USFWS planning. The Everglades Headwaters National Wildlife Refuge (EHNWR) has recently been established, is at the top of the Presidential Administration’s priority conservation areas, and is cited by the Secretary of DOI routinely in the context of conservation. The new refuges were strategically located for both for species adaptation from climate change impacts as well as currently being host to a number of important threatened and endangered species and habitats. We plan to combine a structured decision making framework, optimal solution theory, and output from ecological and sociological models (these modeling efforts were previously funded by DOI partners) that incorporate climate change to provide guidance for EHNWR reserve design. Utilizing a SDM approach and optimal solution theory, decision support tools will be developed that will incorporate stakeholder and agency objectives into targeting conservation lands both through fee simple purchase and other incentives such as easements based on ecological and socioeconomic modeling outputs driven by climate change.

  2. Topology Optimization Design of 3D Continuum Structure with Reserved Hole Based on Variable Density Method

    Directory of Open Access Journals (Sweden)

    Bai Shiye

    2016-05-01

    Full Text Available An objective function defined by minimum compliance of topology optimization for 3D continuum structure was established to search optimal material distribution constrained by the predetermined volume restriction. Based on the improved SIMP (solid isotropic microstructures with penalization model and the new sensitivity filtering technique, basic iteration equations of 3D finite element analysis were deduced and solved by optimization criterion method. All the above procedures were written in MATLAB programming language, and the topology optimization design examples of 3D continuum structure with reserved hole were examined repeatedly by observing various indexes, including compliance, maximum displacement, and density index. The influence of mesh, penalty factors, and filter radius on the topology results was analyzed. Computational results showed that the finer or coarser the mesh number was, the larger the compliance, maximum displacement, and density index would be. When the filtering radius was larger than 1.0, the topology shape no longer appeared as a chessboard problem, thus suggesting that the presented sensitivity filtering method was valid. The penalty factor should be an integer because iteration steps increased greatly when it is a noninteger. The above modified variable density method could provide technical routes for topology optimization design of more complex 3D continuum structures in the future.

  3. Design and Characteristic Analysis of Multicarrier Chaotic Phase Coded Radar Pulse Train Signal

    OpenAIRE

    Huang, Qiongdan; Li, Yong; Zeng, Yaoping; Fu, Yinjuan

    2014-01-01

    By introducing phase code into multicarrier orthogonal frequency division multiplex signal, the multicarrier phase coded (MCPC) radar signal possesses a good spectrum utilization rate and can achieve a good combination of narrowband and wideband processing. Radar pulse train signal not only reserves the high range resolution of monopulse signal, but also has the same velocity resolution performance as continuous wave signal does. In this study, we use the chaotic biphase code generated by Che...

  4. Fluorescence signalling of the transition metal ions: Design strategy ...

    Indian Academy of Sciences (India)

    on fluorescence signalling systems for the transition metal ions. It is shown that even simple fluorophore-spacer-receptor systems can display excellent off-on fluorescence signalling towards the quenching metal ions when the fluorophore ...

  5. Quantification, modelling and design for signal history dependent effects in mixed-signal SOI/SOS circuits

    International Nuclear Information System (INIS)

    Edwards, C.F.; Redman-White, W.; Bracey, M.; Tenbroek, B.M.; Lee, M.S.; Uren, M.J.; Brunson, K.M.

    1999-01-01

    This paper deals with how the radiation hardness of mixed signal SOI/SOS CMOS circuits is taken into account at both architectural terms as well as the the transistor level cell designs. The primary issue is to deal with divergent transistor threshold shifts, and to understand the effects of large amplitude non stationary signals on analogue cell behaviour. (authors)

  6. Improving the Design of a Conservation Reserve for a Critically Endangered Species.

    Science.gov (United States)

    Taylor, Chris; Cadenhead, Natasha; Lindenmayer, David B; Wintle, Brendan A

    2017-01-01

    Setting aside protected areas is a key strategy for tackling biodiversity loss. Reserve effectiveness depends on the extent to which protected areas capture both known occurrences and areas likely to support the species. We assessed the effectiveness of the existing reserve network for Leadbeater's Possum (Gymnobelideus leadbeateri) and other forest-dependent species, and compared the existing reserve system to a set of plausible reserve expansion options based on area targets implied in a recent Population Viability Analysis (PVA). The existing Leadbeater's Reserve and surrounding reserve system captured 7.6% and 29.6% of cumulative habitat suitability, respectively, across the landscape. Expanded reserve scenarios captured 34% to 62% of cumulative habitat suitability. We found acute trade-offs between conserving Leadbeater's Possum habitat and conserving habitat of other forest-dependent species. Our analysis provides a template for systematically expanding and evaluating reserve expansion options in terms of trade-offs between priority species' needs.

  7. Improving the Design of a Conservation Reserve for a Critically Endangered Species.

    Directory of Open Access Journals (Sweden)

    Chris Taylor

    Full Text Available Setting aside protected areas is a key strategy for tackling biodiversity loss. Reserve effectiveness depends on the extent to which protected areas capture both known occurrences and areas likely to support the species. We assessed the effectiveness of the existing reserve network for Leadbeater's Possum (Gymnobelideus leadbeateri and other forest-dependent species, and compared the existing reserve system to a set of plausible reserve expansion options based on area targets implied in a recent Population Viability Analysis (PVA. The existing Leadbeater's Reserve and surrounding reserve system captured 7.6% and 29.6% of cumulative habitat suitability, respectively, across the landscape. Expanded reserve scenarios captured 34% to 62% of cumulative habitat suitability. We found acute trade-offs between conserving Leadbeater's Possum habitat and conserving habitat of other forest-dependent species. Our analysis provides a template for systematically expanding and evaluating reserve expansion options in terms of trade-offs between priority species' needs.

  8. Design of a Modular Signal Conditioning Circuit for Biopotential Sensors

    Directory of Open Access Journals (Sweden)

    Winncy Y. DU

    2010-09-01

    Full Text Available Biosignal conditioning (BC is critical in biomedical instruments because it directly affects measurement accuracy, reliability, and repeatability. BC also presents a great challenge due to the small amplitude of biosignals and their ease of corruption with noise and other disturbances. This paper describes a modular BC system developed for biopotential sensors that can preserve useful information while removing unwanted noise and interference components. This BC circuit includes an instrumentation amplifier, an active 1st-order high-pass filter with Sallen-Key configuration, a 5th-order low-pass Bessel filter, and a 2nd-order Twin-T notch filter. The order of these filters and the associated components in each filter can be easily changed to adapt to different biosignals (modular feature. Data acquisition and sampling were performed using a USB6009 module with a built-in A/D converter. Testing of a real electrocardiogram on the designed signal conditioning circuit demonstrated comparable outputs to commercial devices.

  9. Design of the Chaotic Signal Generator Based on LABVIEW

    Directory of Open Access Journals (Sweden)

    Jian-Guo Zhang

    2014-01-01

    Full Text Available We introduces a new method that can achieve the generation of Colpitts chaotic signal The system is based on virtual instrument platform and combined with MATLAB calculation to achieve the generation of Colpitts chaotic signal and making it analysis with autocorrelation and power spectrum at the same time. Signal channel output of chaotic signal was realized through USB-6009 acquisition module extending DA5405 high-speed DAC (Digital-to-Analog Converter chip. The system can adjust parameters based on customers’ requirements to achieve different frequency chaotic signal generation. Compared with the traditional autonomy Colpitts chaotic signal generator, this generator is simple and clear in structure, simple to operate, strong stability, easy to achieve etc.

  10. Design of PH sensor signal acquisition and display system

    Science.gov (United States)

    Qian, Huifa; Zhang, Quanzhu; Deng, Yonghong

    2017-06-01

    With the continuous development of sensor manufacturing technology, how to better deal with the signal is particularly important. PH value of the sensor voltage generated by the signal as a signal, through the MCU acquisition A / D conversion, and ultimately through the digital display of its PH value. The system uses hardware and software to achieve the results obtained with the high-precision PH meter to strive to improve the accuracy and reduce error.

  11. Digital signal display board design: A knowledge based study

    International Nuclear Information System (INIS)

    Chaitanya, V. Sree Krishna; Rao, C. Raghavendra

    2007-01-01

    The digital signal display board is assumed to be composed of picture tubes for the purpose of displaying characters. The signal board with the picture tubes constitutes an Information System. A methodology for obtaining the discrimable matrix or table (more decisive attributes) and knowledge reduction for the above information system is proposed

  12. The Mixed-Signal ASIC design course at Twente

    NARCIS (Netherlands)

    Stehelin, G.; Tangelder, R.J.W.T.; Gerez, Sabih H.; Kerkhoff, Hans G.; Klumperink, Eric A.M.; Smit, J.; Snijders, H.; Speek, H.; de Vries, H.

    2000-01-01

    In this paper we give a detailed overview of the ASIC design course as it is being given at the Department of Electrical Engineering of the University of Twente. This course covers the complete trajectory from system design via circuit design and actual implementation to testing. Design and testing

  13. Linking proteins to signaling pathways for experiment design and evaluation.

    Directory of Open Access Journals (Sweden)

    Illés J Farkas

    Full Text Available Biomedical experimental work often focuses on altering the functions of selected proteins. These changes can hit signaling pathways, and can therefore unexpectedly and non-specifically affect cellular processes. We propose PathwayLinker, an online tool that can provide a first estimate of the possible signaling effects of such changes, e.g., drug or microRNA treatments. PathwayLinker minimizes the users' efforts by integrating protein-protein interaction and signaling pathway data from several sources with statistical significance tests and clear visualization. We demonstrate through three case studies that the developed tool can point out unexpected signaling bias in normal laboratory experiments and identify likely novel signaling proteins among the interactors of known drug targets. In our first case study we show that knockdown of the Caenorhabditis elegans gene cdc-25.1 (meant to avoid progeny may globally affect the signaling system and unexpectedly bias experiments. In the second case study we evaluate the loss-of-function phenotypes of a less known C. elegans gene to predict its function. In the third case study we analyze GJA1, an anti-cancer drug target protein in human, and predict for this protein novel signaling pathway memberships, which may be sources of side effects. Compared to similar services, a major advantage of PathwayLinker is that it drastically reduces the necessary amount of manual literature searches and can be used without a computational background. PathwayLinker is available at http://PathwayLinker.org. Detailed documentation and source code are available at the website.

  14. Automated Design Tools for Integrated Mixed-Signal Microsystems (NeoCAD)

    National Research Council Canada - National Science Library

    Petre, P; Visher, J; Shringarpure, R; Valley, F; Swaminathan, M

    2005-01-01

    Automated design tools and integrated design flow methodologies were developed that demonstrated more than an order- of-magnitude reduction in cycle time and cost for mixed signal (digital/analoglRF...

  15. Model-based design of self-Adapting networked signal processing systems

    NARCIS (Netherlands)

    Oliveira Filho, J.A. de; Papp, Z.; Djapic, R.; Oostveen, J.C.

    2013-01-01

    The paper describes a model based approach for architecture design of runtime reconfigurable, large-scale, networked signal processing applications. A graph based modeling formalism is introduced to describe all relevant aspects of the design (functional, concurrency, hardware, communication,

  16. A new design of signal processing system for TDI infrared focal plane array

    Science.gov (United States)

    Wang, Hua; Wei, Zhiyong; Lei, Ning; Wang, Xu; Zhang, WenYu; Li, Tao

    2012-12-01

    In this paper, according to the characteristics of TDI infrared focal plane array output signal, a novel signal processing system based on AC coupling technology is proposed. Firstly, the output signal characteristics of TDI infrared focal plane array are analyzed. Secondly, the signal processing system based on AC-coupled technology is introduced. The designed system is consist of high pass filter circuit, signal conditioning circuit, differential input analog to digital converting circuit and digital data processing circuit. Thirdly, the designed system is simulated and tested. Simulation and test results show that the novel design idea of signal processing circuit is reasonable and feasible. Compared with the traditional design, the system has the characteristics of high common mode noise rejection, low temperature drift and low power consumption.

  17. Non-linear and signal energy optimal asymptotic filter design

    Directory of Open Access Journals (Sweden)

    Josef Hrusak

    2003-10-01

    Full Text Available The paper studies some connections between the main results of the well known Wiener-Kalman-Bucy stochastic approach to filtering problems based mainly on the linear stochastic estimation theory and emphasizing the optimality aspects of the achieved results and the classical deterministic frequency domain linear filters such as Chebyshev, Butterworth, Bessel, etc. A new non-stochastic but not necessarily deterministic (possibly non-linear alternative approach called asymptotic filtering based mainly on the concepts of signal power, signal energy and a system equivalence relation plays an important role in the presentation. Filtering error invariance and convergence aspects are emphasized in the approach. It is shown that introducing the signal power as the quantitative measure of energy dissipation makes it possible to achieve reasonable results from the optimality point of view as well. The property of structural energy dissipativeness is one of the most important and fundamental features of resulting filters. Therefore, it is natural to call them asymptotic filters. The notion of the asymptotic filter is carried in the paper as a proper tool in order to unify stochastic and non-stochastic, linear and nonlinear approaches to signal filtering.

  18. Design principles of paradoxical signaling in the immune system

    Science.gov (United States)

    Hart, Yuval

    A widespread feature of cell-cell signaling systems is paradoxical pleiotropy: the same secreted signaling molecule can induce opposite effects in the responding cells. For example, the cytokine IL-2 can promote proliferation and death of T-cells. The role of such paradoxical signaling remains unclear. We suggest that this mechanism provides homeostatic concentration of cells, independent of initial conditions. The crux of the paradoxical mechanism is the combination of a positive and a negative feedback loops creating two stable states - an OFF state and an ON state. Experimentally, we found that CD4 + cells grown in culture with a 30-fold difference in initial concentrations reached a homeostatic concentration nearly independent of initial cell levels (ON-state). Below an initial threshold, cell density decayed to extinction (OFF-state). Mathematical modeling explained the observed cell and cytokine dynamics and predicted conditions that shifted cell fate from homeostasis to the OFF-state. We suggest that paradoxical signaling provides cell circuits with specific dynamical features that are robust to environmental perturbations.

  19. The design of pipeline digital signal generator based on VME BUS

    International Nuclear Information System (INIS)

    Wei Shujun; Liu Zhenan; Zhao Dixin; Guo Ya'nan

    2006-01-01

    The paper describes the principle, design and implement of Pipelined digital signal generator based on VME BUS. Furthermore, the paper expands the design in details on how to achieve the complex control with the CPLD. An implementation of Pipelined digital signal generator is provided. (authors)

  20. Design of General-purpose Industrial signal acquisition system in a large scientific device

    Science.gov (United States)

    Ren, Bin; Yang, Lei

    2018-02-01

    In order to measure the industrial signal of a large scientific device experiment, a set of industrial data general-purpose acquisition system has been designed. It can collect 4~20mA current signal and 0~10V voltage signal. Through the practical experiments, it shows that the system is flexible, reliable, convenient and economical, and the system has characters of high definition and strong anti-interference ability. Thus, the system fully meets the design requirements..

  1. Design and Modelling of Thermostatically Controlled Loads as Frequency Controlled Reserve

    DEFF Research Database (Denmark)

    Xu, Zhao; Østergaard, Jacob; Togeby, Mikael

    2007-01-01

    Using demand as frequency controlled reserve (DFR) is beneficial to power systems in many aspects. To study the impacts of this technology on power system operation, control logics and simulation models of relevant loads should be carefully developed. Two advanced control logics for using demand...... frequency, is developed. The developed simulation model is able to represent a variety of aggregated thermostatically controlled loads, such as heaters or refrigerators. Uncertainties including customer behaviours and ambient temperature variation are also modelled. Preliminary simulation results...

  2. Mechanical design in embryos: mechanical signalling, robustness and developmental defects.

    Science.gov (United States)

    Davidson, Lance A

    2017-05-19

    Embryos are shaped by the precise application of force against the resistant structures of multicellular tissues. Forces may be generated, guided and resisted by cells, extracellular matrix, interstitial fluids, and how they are organized and bound within the tissue's architecture. In this review, we summarize our current thoughts on the multiple roles of mechanics in direct shaping, mechanical signalling and robustness of development. Genetic programmes of development interact with environmental cues to direct the composition of the early embryo and endow cells with active force production. Biophysical advances now provide experimental tools to measure mechanical resistance and collective forces during morphogenesis and are allowing integration of this field with studies of signalling and patterning during development. We focus this review on concepts that highlight this integration, and how the unique contributions of mechanical cues and gradients might be tested side by side with conventional signalling systems. We conclude with speculation on the integration of large-scale programmes of development, and how mechanical responses may ensure robust development and serve as constraints on programmes of tissue self-assembly.This article is part of the themed issue 'Systems morphodynamics: understanding the development of tissue hardware'. © 2017 The Author(s).

  3. Analysis of Design of Mixed-Signal Electronic Packaging

    National Research Council Canada - National Science Library

    Pileggi, Lawrence

    1999-01-01

    ... to what is possible today for ICs. The proposed advances are considered on several fronts: (1) new algorithms and definitions for magnetic vector potentials which permit simplified inductance estimates for early phases of design...

  4. On signal design by the R/0/ criterion for non-white Gaussian noise channels

    Science.gov (United States)

    Bordelon, D. L.

    1977-01-01

    The use of the cut-off rate criterion for modulation system design is investigated for channels with non-white Gaussian noise. A signal space representation of the waveform channel is developed, and the cut-off rate for vector channels with additive non-white Gaussian noise and unquantized demodulation is derived. When the signal input to the channel is a continuous random vector, maximization of the cut-off rate with constrained average signal energy leads to a water-filling interpretation of optimal energy distribution in signal space. The necessary condition for a finite signal set to maximize the cut-off rate with constrained energy and an equally likely probability assignment of signal vectors is presented, and an algorithm is outlined for numerically computing the optimum signal set. As an example, the rectangular signal set which has the water-filling average energy distribution and the optimum rectangular set are compared.

  5. Method of test signal design for estimating the aircraft aerodynamic parameters

    Science.gov (United States)

    Belokon', S. A.; Zolotukhin, Yu. N.; Filippov, M. N.

    2017-07-01

    A method of test signal design is proposed for studying the aircraft aerodynamic characteristics with the use of the technology of dynamically scaled free-flight models. Simultaneous excitation of all input channels in a prescribed frequency band by a set of mutually orthogonal signals is applied to increase the efficiency. A modified method of calculating the set of mutually orthogonal sinusoidal signals with a small normalized peak factor is presented. Results of simulating the aircraft motion in the MATLAB/Simulink environment with the use of the developed method of test signal design are reported.

  6. Design and analysis of UW-OFDM signals.

    Science.gov (United States)

    Huemer, Mario; Hofbauer, Christian; Onic, Alexander; Huber, Johannes B

    2014-10-01

    Unique word-orthogonal frequency division multiplexing (UW-OFDM) is a novel signaling concept where the guard interval is implemented as a deterministic sequence, the so-called unique word. The UW is generated by introducing a certain level of redundancy in the frequency domain. Different data estimation strategies and the favourable bit error ratio (BER) performance of UW-OFDM, as well as comparisons to competing concepts have already extensively been discussed in previous papers. This work focuses on the different possibilities on how to generate UW-OFDM signals. The optimality of the two-step over the direct approach in systematic UW-OFDM is proved analytically, we present a heuristic algorithm that allows a fast numerical optimization of the redundant subcarrier positions, and we show that our original intuitive approach of spreading the redundant subcarriers in systematically encoded UW-OFDM by minimizing the mean redundant energy is practically also optimum w.r.t. transceiver based cost functions. Finally, we derive closed form approximations of the statistical symbol distributions on individual subcarriers as well as the redundant energy distribution and compare them with numerically found results.

  7. Annotated mitochondrial genome with Nanopore R9 signal for Nippostrongylus brasiliensis [version 1; referees: 1 approved, 2 approved with reservations

    Directory of Open Access Journals (Sweden)

    Jodie Chandler

    2017-01-01

    Full Text Available Nippostrongylus brasiliensis, a nematode parasite of rodents, has a parasitic life cycle that is an extremely useful model for the study of human hookworm infection, particularly in regards to the induced immune response. The current reference genome for this parasite is highly fragmented with minimal annotation, but new advances in long-read sequencing suggest that a more complete and annotated assembly should be an achievable goal. We de-novo assembled a single contig mitochondrial genome from N. brasiliensis using MinION R9 nanopore data. The assembly was error-corrected using existing Illumina HiSeq reads, and annotated in full (i.e. gene boundary definitions without substantial gaps by comparing with annotated genomes from similar parasite relatives. The mitochondrial genome has also been annotated with a preliminary electrical consensus sequence, using raw signal data generated from a Nanopore R9 flow cell.

  8. The Signal Detection and Control Circuit Design for Confocal Auto-Focus System

    Directory of Open Access Journals (Sweden)

    Yin Liu

    2016-01-01

    Full Text Available Based on the demands of Confocal Auto-Focus system, the implementation method of signal measurement circuit and control circuit is given. Using the high performance instrumental amplifier AD620BN, low noise precision FET Op amplifier AD795JRZ and ultralow offset voltage Op amplifier OP07EP, a signal measurement circuit used to converse the two differential light intensity signal to electric signal is designed. And a control circuit which takes MCU MSP430F149 as core processes the former signal and generate a control signal driving the platform for auto-focusing. The experimental results proved the feasibility and correctness of circuits. And the system meets the design requirement.

  9. Assessment of Li/SOCl2 battery technology: Reserve, thin-cell design, volume 3

    Science.gov (United States)

    Mosier-Boss, P. A.; Szpak, S.

    1990-06-01

    In choosing and developing a battery system, extensive research, i.e., computer modeling and electrochemistry experiments is required. The kinetics of chemical and electrochemical reactions determine the operational characteristics of a battery, including discharge rate capability and shelf storage life. This in turn affects power output. Battery design also affects battery output, i.e., distance between the bipolar plates, thickness of the electrodes and spacers, materials used, uniformity of electrolyte flow, etc. To maximize the performance of a battery system, therefore, one must do basic research ot identify the electrochemical and chemical process occurring within the battery. Too often this has not been done with the expected results. With regards to Li/SOCl2 battery development program described in Volume 1 of TR 1154, this volume contains a compilation of technical papers and is a continuation of Volume 2 of TR 1154. These papers have appeared in referred journals and books. In addition, abstracts of presentations given at meetings and a table of contents for the previous two volumes of TR 1154 are included. This work was performed as part of the Naval Ocean Systems Center Independent Exploratory Development program and constitutes a portion of a program whose goal is to establish a technology base for high-discharge rate Li/SOCl2 batteries.

  10. Design of the Acoustic Signal Receiving Unit of Acoustic Telemetry While Drilling

    Directory of Open Access Journals (Sweden)

    Li Zhigang

    2016-01-01

    Full Text Available Signal receiving unit is one of the core units of the acoustic telemetry system. A new type of acoustic signal receiving unit is designed to solve problems of the existing devices. The unit is a short joint in whole. It not only can receive all the acoustic signals transmitted along the drill string, without losing any signal, but will not bring additional vibration and interference. In addition, the structure of the amplitude transformer is designed, which can amplify the signal amplitude and improve the receiving efficiency. The design of the wireless communication module makes the whole device can be used in normal drilling process when the drill string is rotating. So, it does not interfere with the normal drilling operation.

  11. The signal software environment for real-time system specification, design, and implementation

    OpenAIRE

    Benveniste , Albert; Le Guernic , Paul; Jacquemot , Christian

    1989-01-01

    In this paper, "reactive systems", i.e. systems which interact permanently with their environment, are considered. Such systems are encountered, for instance, in real-time control or signal processing systems, command-control-communication system, man-machine interfaces, to mention just a few. We present the Signal software environment designed and developped at INRIA-IRISA and its formal calculus system to perform the above mentioned tasks. We outline the principles of the Signal "synchronou...

  12. Design and implementation of a hybrid circuit system for micro sensor signal processing

    International Nuclear Information System (INIS)

    Wang Zhuping; Chen Jing; Liu Ruqing

    2011-01-01

    This paper covers a micro sensor analog signal processing circuit system (MASPS) chip with low power and a digital signal processing circuit board implementation including hardware connection and software design. Attention has been paid to incorporate the MASPS chip into the digital circuit board. The ultimate aim is to form a hybrid circuit used for mixed-signal processing, which can be applied to a micro sensor flow monitoring system. (semiconductor integrated circuits)

  13. Evolution and Design Governing Signal Precision and Amplification in a Bacterial Chemosensory Pathway

    OpenAIRE

    Guzzo, Mathilde; Agrebi, Rym; Espinosa, Leon; Baronian, Gr?gory; Molle, Virginie; Mauriello, Emilia M. F.; Brochier-Armanet, C?line; Mignot, T?m

    2015-01-01

    Author Summary Deciphering the circuit design of signal transduction networks is a fundamental question in cell biology. This task is challenging because many pathways are branched and control multiple cellular processes in response to one or several environmental signals. Studying pathway diversification in bacteria could be a powerful approach because these organisms contain so-called chemosensory systems, modular signaling units that have been adapted multiple times independently to regula...

  14. Design and implementation of ATCA-based 100Gbps DP-QPSK optical signal test instrument

    Science.gov (United States)

    Su, Shaojing; Qin, Jiangyi; Huang, Zhiping; Liu, Chenwu

    2014-11-01

    In order to achieve the receiving task of 100Gbps Dual Polarization-Quadrature Phase Shift Keying (DP-QPSK) optical signal acquisition instrument, improve acquisition performance of the instrument, this paper has deeply researched DP-QPSK modulation principles, demodulation techniques and the key technologies of optical signal acquisition. The theories of DP-QPSK optical signal transmission are researched. The DP-QPSK optical signal transmission model is deduced. And the clock and data recovery in high-speed data acquisition and offset correction of multi-channel data are researched. By reasonable hardware circuit design and software system construction, the utilization of high performance Advanced Telecom Computing Architecture (ATCA), this paper proposes a 100Gbps DP-QPSK optical signal acquisition instrument which is based on ATCA. The implementations of key modules are presented by comparison and argumentation. According to the modularization idea, the instrument can be divided into eight modules. Each module performs the following functions. (1) DP-QPSK coherent detection demodulation module; (2) deceleration module; (3) FPGA (Field Programmable Gate Array); (4) storage module; (5) data transmission module; (6) clock module; (7) power module; (8) JTAG debugging, configuration module; What is more, this paper has put forward two solutions to test optical signal acquisition instrument performance. The first scenario is based on a standard STM-256 optical signal format and exploits the SignalTap of QuartusII software to monitor the optical signal data. Another scenario is to use a pseudo-random signal series to generate data, acquisition module acquires a certain amount of data signals, and then the signals are transferred to a computer by the Gigabit Ethernet to analyze. Two testing results show that the bit error rate of optical signal acquisition instrument is low. And the instrument fully meets the requirements of signal receiving system. At the same time

  15. Design of eight-channel ADC card for GHz signal conversion

    CERN Document Server

    Habib, Samer Bou; Jalmuzna, Wojciech; Jezynski, Tomasz

    2011-01-01

    This paper describes the design of an eight-channel ATCA card suited for direct analog-to-digital conversion of 1.3 GHz signals with a maximum ADC clock frequency of 500 MHz. The undersampling operation is used for signal conversion. This card was designed for the needs of the LLRF system of the FLASH and XFEL accelerators. The designed module consists of a main ATCA board with eight ADCs, FPGA unit, memory, power supply and diagnostic circuits. The main ATCA card allows connecting a daughter board with IPMI, CPU and fast interfaces for communication purposes. This paper describes such issues as system organization allowing acquisition of data at such high data rates, circuit synchronization by high-quality clock signals, CPU and connectivity features, 20-layer PCB design and techniques used for high-frequency signals transmission and matching.

  16. Optimal Design of Calibration Signals in Space Borne Gravitational Wave Detectors

    Science.gov (United States)

    Nofrarias, Miquel; Karnesis, Nikolaos; Gibert, Ferran; Armano, Michele; Audley, Heather; Danzmann, Karsten; Diepholz, Ingo; Dolesi, Rita; Ferraioli, Luigi; Thorpe, James I.

    2014-01-01

    Future space borne gravitational wave detectors will require a precise definition of calibration signals to ensure the achievement of their design sensitivity. The careful design of the test signals plays a key role in the correct understanding and characterization of these instruments. In that sense, methods achieving optimal experiment designs must be considered as complementary to the parameter estimation methods being used to determine the parameters describing the system. The relevance of experiment design is particularly significant for the LISA Pathfinder mission, which will spend most of its operation time performing experiments to characterize key technologies for future space borne gravitational wave observatories. Here we propose a framework to derive the optimal signals in terms of minimum parameter uncertainty to be injected to these instruments during its calibration phase. We compare our results with an alternative numerical algorithm which achieves an optimal input signal by iteratively improving an initial guess. We show agreement of both approaches when applied to the LISA Pathfinder case.

  17. Optimal Design of Calibration Signals in Space-Borne Gravitational Wave Detectors

    Science.gov (United States)

    Nofrarias, Miquel; Karnesis, Nikolaos; Gibert, Ferran; Armano, Michele; Audley, Heather; Danzmann, Karsten; Diepholz, Ingo; Dolesi, Rita; Ferraioli, Luigi; Ferroni, Valerio; hide

    2016-01-01

    Future space borne gravitational wave detectors will require a precise definition of calibration signals to ensure the achievement of their design sensitivity. The careful design of the test signals plays a key role in the correct understanding and characterisation of these instruments. In that sense, methods achieving optimal experiment designs must be considered as complementary to the parameter estimation methods being used to determine the parameters describing the system. The relevance of experiment design is particularly significant for the LISA Pathfinder mission, which will spend most of its operation time performing experiments to characterize key technologies for future space borne gravitational wave observatories. Here we propose a framework to derive the optimal signals in terms of minimum parameter uncertainty to be injected to these instruments during its calibration phase. We compare our results with an alternative numerical algorithm which achieves an optimal input signal by iteratively improving an initial guess. We show agreement of both approaches when applied to the LISA Pathfinder case.

  18. Extreme low-power mixed signal IC design

    CERN Document Server

    Tajalli, Armin

    2010-01-01

    This book describes a completely novel class of techniques for designing ultra-low-power integrated circuits (ICs). In many applications such as battery operated systems and battery-less (energy-scavenging) systems, power dissipation is a critical parameter. As a result, there is a growing demand for reducing the power (energy) consumption in ICs to extremely low levels, not achievable by using classical ""subthreshold CMOS"" techniques. This book introduces a new family of ""subthreshold circuits"" called ""source-coupled circuits"". This family of circuits can be used for implementing digita

  19. Systems engineering principles for the design of biomedical signal processing systems.

    Science.gov (United States)

    Faust, Oliver; Acharya U, Rajendra; Sputh, Bernhard H C; Min, Lim Choo

    2011-06-01

    Systems engineering aims to produce reliable systems which function according to specification. In this paper we follow a systems engineering approach to design a biomedical signal processing system. We discuss requirements capturing, specification definition, implementation and testing of a classification system. These steps are executed as formal as possible. The requirements, which motivate the system design, are based on diabetes research. The main requirement for the classification system is to be a reliable component of a machine which controls diabetes. Reliability is very important, because uncontrolled diabetes may lead to hyperglycaemia (raised blood sugar) and over a period of time may cause serious damage to many of the body systems, especially the nerves and blood vessels. In a second step, these requirements are refined into a formal CSP‖ B model. The formal model expresses the system functionality in a clear and semantically strong way. Subsequently, the proven system model was translated into an implementation. This implementation was tested with use cases and failure cases. Formal modeling and automated model checking gave us deep insight in the system functionality. This insight enabled us to create a reliable and trustworthy implementation. With extensive tests we established trust in the reliability of the implementation. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  20. Design of EEG Signal Acquisition System Using Arduino MEGA1280 and EEGAnalyzer

    Directory of Open Access Journals (Sweden)

    Saptono Debyo

    2016-01-01

    Full Text Available This study integrates the hardware circuit design and software development to achieve a 16 channels Electroencephalogram (EEG system for Brain Computer Interface (BCI applications. Signals obtained should be strong enough amplitude that is usually expressed in units of millivolts and reasonably clean of noise that appears when the data acquisition process. The process of data acquisition consists of two stages are the acquisition of the original EEG signal can be done by the active electrode with an instrumentation amplifier or a preamplifier and processing the signal to get better signals with improved signal quality by removing noise using filters with IC OPAMP. The design of a preamplifier with high common-mode rejection ratio and high signal-to-noise ratio is very important. Moreover, the friction between the electrode pads and the skin as well as the design of dual power supply. Designs used single-power AC-coupled circuit, which effectively reduces the DC bias and improves the error caused by the effects of part errors. At the same time, the digital way is applied to design the adjustable amplification and filter function, which can design for different EEG frequency bands. The next step, those EEG signals received by the microcontroller through a port Analog to Digital Converter (ADC that integrated and converted into digital signals and stored in the RAM of microcontroller which simultaneously at 16 ports in accordance with the minimal number of points of data collection on the human scalp. Implementation results have shown the series of acquisitions to work properly so that it can be displayed EEG signals via software EEGAnalyzer.

  1. Regulation of the reserve carbohydrate metabolism by alkaline pH and calcium in Neurospora crassa reveals a possible cross-regulation of both signaling pathways.

    Science.gov (United States)

    Virgilio, Stela; Cupertino, Fernanda Barbosa; Ambrosio, Daniela Luz; Bertolini, Maria Célia

    2017-06-09

    Glycogen and trehalose are storage carbohydrates and their levels in microorganisms vary according to environmental conditions. In Neurospora crassa, alkaline pH stress highly influences glycogen levels, and in Saccharomyces cerevisiae, the response to pH stress also involves the calcineurin signaling pathway mediated by the Crz1 transcription factor. Recently, in yeast, pH stress response genes were identified as targets of Crz1 including genes involved in glycogen and trehalose metabolism. In this work, we present evidence that in N. crassa the glycogen and trehalose metabolism is modulated by alkaline pH and calcium stresses. We demonstrated that the pH signaling pathway in N. crassa controls the accumulation of the reserve carbohydrates glycogen and trehalose via the PAC-3 transcription factor, which is the central regulator of the signaling pathway. The protein binds to the promoters of most of the genes encoding enzymes of glycogen and trehalose metabolism and regulates their expression. We also demonstrated that the reserve carbohydrate levels and gene expression are both modulated under calcium stress and that the response to calcium stress may involve the concerted action of PAC-3. Calcium activates growth of the Δpac-3 strain and influences its glycogen and trehalose accumulation. In addition, calcium stress differently regulates glycogen and trehalose metabolism in the mutant strain compared to the wild-type strain. While glycogen levels are decreased in both strains, the trehalose levels are significantly increased in the wild-type strain and not affected by calcium in the mutant strain when compared to mycelium not exposed to calcium. We previously reported the role of PAC-3 as a transcription factor involved in glycogen metabolism regulation by controlling the expression of the gsn gene, which encodes an enzyme of glycogen synthesis. In this work, we extended the investigation by studying in greater detail the effects of pH on the metabolism of the

  2. Traffic signal design and simulation for vulnerable road users safety and bus preemption

    International Nuclear Information System (INIS)

    Lo, Shih-Ching; Huang, Hsieh-Chu

    2015-01-01

    Mostly, pedestrian car accidents occurred at a signalized interaction is because pedestrians cannot across the intersection safely within the green light. From the viewpoint of pedestrian, there might have two reasons. The first one is pedestrians cannot speed up to across the intersection, such as the elders. The other reason is pedestrians do not sense that the signal phase is going to change and their right-of-way is going to be lost. Developing signal logic to protect pedestrian, who is crossing an intersection is the first purpose of this study. In addition, to improve the reliability and reduce delay of public transportation service is the second purpose. Therefore, bus preemption is also considered in the designed signal logic. In this study, the traffic data of the intersection of Chong-Qing North Road and Min-Zu West Road, Taipei, Taiwan, is employed to calibrate and validate the signal logic by simulation. VISSIM 5.20, which is a microscopic traffic simulation software, is employed to simulate the signal logic. From the simulated results, the signal logic presented in this study can protect pedestrians crossing the intersection successfully. The design of bus preemption can reduce the average delay. However, the pedestrian safety and bus preemption signal will influence the average delay of cars largely. Thus, whether applying the pedestrian safety and bus preemption signal logic to an intersection or not should be evaluated carefully

  3. Reconfigurable signal processor designs for advanced digital array radar systems

    Science.gov (United States)

    Suarez, Hernan; Zhang, Yan (Rockee); Yu, Xining

    2017-05-01

    The new challenges originated from Digital Array Radar (DAR) demands a new generation of reconfigurable backend processor in the system. The new FPGA devices can support much higher speed, more bandwidth and processing capabilities for the need of digital Line Replaceable Unit (LRU). This study focuses on using the latest Altera and Xilinx devices in an adaptive beamforming processor. The field reprogrammable RF devices from Analog Devices are used as analog front end transceivers. Different from other existing Software-Defined Radio transceivers on the market, this processor is designed for distributed adaptive beamforming in a networked environment. The following aspects of the novel radar processor will be presented: (1) A new system-on-chip architecture based on Altera's devices and adaptive processing module, especially for the adaptive beamforming and pulse compression, will be introduced, (2) Successful implementation of generation 2 serial RapidIO data links on FPGA, which supports VITA-49 radio packet format for large distributed DAR processing. (3) Demonstration of the feasibility and capabilities of the processor in a Micro-TCA based, SRIO switching backplane to support multichannel beamforming in real-time. (4) Application of this processor in ongoing radar system development projects, including OU's dual-polarized digital array radar, the planned new cylindrical array radars, and future airborne radars.

  4. Circuit Design to Stabilize the Reflectometer Local Oscillator Signals

    International Nuclear Information System (INIS)

    Kung CC; Kramer GJ; Johnson E; Solomon W; Nazikian R.

    2005-01-01

    Reflectometry, which uses the microwave radar technique to probe the magnetically confined fusion plasmas, is a very powerful tool to observe the density fluctuations in the fusion plasmas. Typically, two or more microwave beams of different frequencies are used to study the plasma density fluctuations. The frequency separation between these two beams of the PPPL designed reflectometer system upgrade on the DIII-D tokamak can be varied over 18 GHz. Due to the performance of the associated electronics, the local oscillator (LO) power level at the LO port of the I/Q demodulator suffers more than 12 dB of power fluctuations when the frequency separation is varied. Thus, the I/Q demodulator performance is impaired. In order to correct this problem, a power leveling circuit is introduced in the PPPL upgrade. According to the test results, the LO power fluctuation was regulated to be within 1 dB for greater than 16 dB of input power variation over the full dynamic bandwidth of the receiver

  5. A basic study on universal design of auditory signals in automobiles.

    Science.gov (United States)

    Yamauchi, Katsuya; Choi, Jong-dae; Maiguma, Ryo; Takada, Masayuki; Iwamiya, Shin-ichiro

    2004-11-01

    In this paper, the impression of various kinds of auditory signals currently used in automobiles and a comprehensive evaluation were measured by a semantic differential method. The desirable acoustic characteristic was examined for each type of auditory signal. Sharp sounds with dominant high-frequency components were not suitable for auditory signals in automobiles. This trend is expedient for the aged whose auditory sensitivity in the high frequency region is lower. When intermittent sounds were used, a longer OFF time was suitable. Generally, "dull (not sharp)" and "calm" sounds were appropriate for auditory signals. Furthermore, the comparison between the frequency spectrum of interior noise in automobiles and that of suitable sounds for various auditory signals indicates that the suitable sounds are not easily masked. The suitable auditory signals for various purposes is a good solution from the viewpoint of universal design.

  6. Population Connectivity Measures of Fishery-Targeted Coral Reef Species to Inform Marine Reserve Network Design in Fiji.

    Science.gov (United States)

    Eastwood, Erin K; López, Elora H; Drew, Joshua A

    2016-01-25

    Coral reef fish serve as food sources to coastal communities worldwide, yet are vulnerable to mounting anthropogenic pressures like overfishing and climate change. Marine reserve networks have become important tools for mitigating these pressures, and one of the most critical factors in determining their spatial design is the degree of connectivity among different populations of species prioritized for protection. To help inform the spatial design of an expanded reserve network in Fiji, we used rapidly evolving mitochondrial genes to investigate connectivity patterns of three coral reef species targeted by fisheries in Fiji: Epinephelus merra (Serranidae), Halichoeres trimaculatus (Labridae), and Holothuria atra (Holothuriidae). The two fish species, E. merra and Ha. trimaculatus, exhibited low genetic structuring and high amounts of gene flow, whereas the sea cucumber Ho. atra displayed high genetic partitioning and predominantly westward gene flow. The idiosyncratic patterns observed among these species indicate that patterns of connectivity in Fiji are likely determined by a combination of oceanographic and ecological characteristics. Our data indicate that in the cases of species with high connectivity, other factors such as representation or political availability may dictate where reserves are placed. In low connectivity species, ensuring upstream and downstream connections is critical.

  7. On signal design by the R sub 0 criterion for non-white Gaussian noise channels

    Science.gov (United States)

    Bordelon, D. L.

    1976-01-01

    The use of the R sub 0 criterion for modulation system design is investigated for channels with non-white Gaussian noise. A signal space representation of the waveform channel is developed, and the cut-off rate R sub 0 for vector channels with additive nonwhite Gaussian noise and unquantized demodulation is derived. When the signal unput to the channel is a continuous random vector, maximization of R sub 0 with constrained average signal energy leads to a water-filling interpretation of optimal energy distribution in signal space. The necessary condition for a finite signal set to maximize R sub 0 with constrained energy and an equally likely probability assignment of signal vectors is presented, and an algorithm is outlined for numerically computing the optimum signal set. A necessary condition on a constrained energy, finite signal set is found which maximizes a Taylor series approximation of R sub 0. This signal set is compared with the finite signal set which has the water-filling average energy distribution.

  8. Design of acoustic logging signal source of imitation based on field programmable gate array

    Science.gov (United States)

    Zhang, K.; Ju, X. D.; Lu, J. Q.; Men, B. Y.

    2014-08-01

    An acoustic logging signal source of imitation is designed and realized, based on the Field Programmable Gate Array (FPGA), to improve the efficiency of examining and repairing acoustic logging tools during research and field application, and to inspect and verify acoustic receiving circuits and corresponding algorithms. The design of this signal source contains hardware design and software design,and the hardware design uses an FPGA as the control core. Four signals are made first by reading the Random Access Memory (RAM) data which are inside the FPGA, then dealing with the data by digital to analog conversion, amplification, smoothing and so on. Software design uses VHDL, a kind of hardware description language, to program the FPGA. Experiments illustrate that the ratio of signal to noise for the signal source is high, the waveforms are stable, and also its functions of amplitude adjustment, frequency adjustment and delay adjustment are in accord with the characteristics of real acoustic logging waveforms. These adjustments can be used to imitate influences on sonic logging received waveforms caused by many kinds of factors such as spacing and span of acoustic tools, sonic speeds of different layers and fluids, and acoustic attenuations of different cementation planes.

  9. Design of a dataway processor for a parallel image signal processing system

    Science.gov (United States)

    Nomura, Mitsuru; Fujii, Tetsuro; Ono, Sadayasu

    1995-04-01

    Recently, demands for high-speed signal processing have been increasing especially in the field of image data compression, computer graphics, and medical imaging. To achieve sufficient power for real-time image processing, we have been developing parallel signal-processing systems. This paper describes a communication processor called 'dataway processor' designed for a new scalable parallel signal-processing system. The processor has six high-speed communication links (Dataways), a data-packet routing controller, a RISC CORE, and a DMA controller. Each communication link operates at 8-bit parallel in a full duplex mode at 50 MHz. Moreover, data routing, DMA, and CORE operations are processed in parallel. Therefore, sufficient throughput is available for high-speed digital video signals. The processor is designed in a top- down fashion using a CAD system called 'PARTHENON.' The hardware is fabricated using 0.5-micrometers CMOS technology, and its hardware is about 200 K gates.

  10. Signal charge sharing in multilinear drift detectors: Design and experimental characterization

    Energy Technology Data Exchange (ETDEWEB)

    Castoldi, A. [Univ. degli Studi di Milano (Italy). Dipt. di Fisica; Rehak, P. [Brookhaven National Lab., Upton, NY (United States); Holl, P. [3MPI Halbleiterlabor, Muenchen (Germany)

    1997-04-01

    Multilinear silicon drift detectors (MLSDD`s) are radiation detectors which combine excellent energy and position resolution with high count-rate capabilities. This is achieved by controlling the diffusion of the signal charges and limiting their lateral spread during the drift. This paper will present a study of the signal electrons` transport in MLSDD`s in comparison with the experimental measurements. Three-dimensional simulations were carried out, taking into account diffusion effects and mutual electrostatic interaction between the signal electrons. A representative sample of these simulations will be presented. Signal sharing in a multilinear drift detector and in a classical multi-anode drift detector are characterized and discussed. The results are useful to tailor the design of MLSDD`s for the detection of different kinds of radiation (e.g., optical photon, X-ray, ionizing particle) and to optimize signal charge sharing and detector performance according to a particular application purpose.

  11. Analog CMOS design for optical coherence tomography signal detection and processing.

    Science.gov (United States)

    Xu, Wei; Mathine, David L; Barton, Jennifer K

    2008-02-01

    A CMOS circuit was designed and fabricated for optical coherence tomography (OCT) signal detection and processing. The circuit includes a photoreceiver, differential gain stage and lock-in amplifier based demodulator. The photoreceiver consists of a CMOS photodetector and low noise differential transimpedance amplifier which converts the optical interference signal into a voltage. The differential gain stage further amplifies the signal. The in-phase and quadrature channels of the lock-in amplifier each include an analog mixer and switched-capacitor low-pass filter with an external mixer reference signal. The interferogram envelope and phase can be extracted with this configuration, enabling Doppler OCT measurements. A sensitivity of -80 dB is achieved with faithful reproduction of the interferometric signal envelope. A sample image of finger tip is presented.

  12. Echolocating bats rely on audiovocal feedback to adapt sonar signal design.

    Science.gov (United States)

    Luo, Jinhong; Moss, Cynthia F

    2017-10-10

    Many species of bat emit acoustic signals and use information carried by echoes reflecting from nearby objects to navigate and forage. It is widely documented that echolocating bats adjust the features of sonar calls in response to echo feedback; however, it remains unknown whether audiovocal feedback contributes to sonar call design. Audiovocal feedback refers to the monitoring of one's own vocalizations during call production and has been intensively studied in nonecholocating animals. Audiovocal feedback not only is a necessary component of vocal learning but also guides the control of the spectro-temporal structure of vocalizations. Here, we show that audiovocal feedback is directly involved in the echolocating bat's control of sonar call features. As big brown bats tracked targets from a stationary position, we played acoustic jamming signals, simulating calls of another bat, timed to selectively perturb audiovocal feedback or echo feedback. We found that the bats exhibited the largest call-frequency adjustments when the jamming signals occurred during vocal production. By contrast, bats did not show sonar call-frequency adjustments when the jamming signals coincided with the arrival of target echoes. Furthermore, bats rapidly adapted sonar call design in the first vocalization following the jamming signal, revealing a response latency in the range of 66 to 94 ms. Thus, bats, like songbirds and humans, rely on audiovocal feedback to structure sonar signal design.

  13. IIR digital filter design for powerline noise cancellation of ECG signal using arduino platform

    Science.gov (United States)

    Rahmatillah, Akif; Ataulkarim

    2017-05-01

    Powerline noise has been one of significant noises of Electrocardiogram (ECG) signal measurement. This noise is characterized by a sinusoidal signal which has 50 Hz of noise and 0.3 mV of maximum amplitude. This paper describes the design of IIR Notch filter design to reject a 50 Hz power line noise. IIR filter coefficients were calculated using pole placement method with three variations of band stop cut off frequencies of (49-51)Hz, (48 - 52)Hz, and (47 - 53)Hz. The algorithm and coefficients of filter were embedded to Arduino DUE (ARM 32 bit microcontroller). IIR notch filter designed has been able to reject power line noise with average square of error value of 0.225 on (49-51) Hz filter design and 0.2831 on (48 - 52)Hz filter design.

  14. Design of a signal conditioner for the Fermilab Magnet Test Facility

    Energy Technology Data Exchange (ETDEWEB)

    Giannelli, Pietro [Turin Polytechnic

    2012-01-01

    This thesis describes the design of a remotely-programmable signal conditioner for the harmonic measurement of accelerator magnets. A 10-channel signal conditioning circuit featuring bucking capabilities was designed from scratch and implemented to the level of the printed circuit board layout. Other system components were chosen from those available on the market. Software design was started with the definition of routine procedures. This thesis is part of an upgrade project for replacing obsolescent automated test equipment belonging to the Fermilab Magnet Test Facility. The design started with a given set of requirements. Using a top-down approach, all the circuits were designed and their expected performances were theoretically predicted and simulated. A limited prototyping phase followed. The printed circuit boards were laid out and routed using a CAD software and focusing the design on maximum electromagnetic interference immunity. An embedded board was selected for controlling and interfacing the signal conditioning circuitry with the instrumentation network. Basic low level routines for hardware access were defined. This work covered the entire design process of the signal conditioner, resulting in a project ready for manufacturing. The expected performances are in line with the requirements and, in the cases where this was not possible, approval of trade-offs was sought and received from the end users. Part I deals with the global structure of the signal conditioner and the subdivision in functional macro-blocks. Part II treats the hardware design phase in detail, covering the analog and digital circuits, the printed circuit layouts, the embedded controller and the power supply selection. Part III deals with the basic hardware-related routines to be implemented in the final software.

  15. Model observer design for multi-signal detection in the presence of anatomical noise

    Science.gov (United States)

    Wen, Gezheng; Markey, Mia K.; Park, Subok

    2017-02-01

    As psychophysical studies are resource-intensive to conduct, model observers are commonly used to assess and optimize medical imaging quality. Model observers are typically designed to detect at most one signal. However, in clinical practice, there may be multiple abnormalities in a single image set (e.g. multifocal multicentric (MFMC) breast cancer), which can impact treatment planning. Prevalence of signals can be different across anatomical regions, and human observers do not know the number or location of signals a priori. As new imaging techniques have the potential to improve multiple-signal detection (e.g. digital breast tomosynthesis may be more effective for diagnosis of MFMC than mammography), image quality assessment approaches addressing such tasks are needed. In this study, we present a model observer to detect multiple signals in an image dataset. A novel implementation of partial least squares (PLS) was developed to estimate different sets of efficient channels directly from the images. The PLS channels are adaptive to the characteristics of signals and the background, and they capture the interactions among signal locations. Corresponding linear decision templates are employed to generate both image-level and location-specific scores on the presence of signals. Our results show that: (1) the model observer can achieve high performance with a reasonably small number of channels; (2) the model observer with PLS channels outperforms that with benchmark modified Laguerre-Gauss channels, especially when realistic signal shapes and complex background statistics are involved; (3) the tasks of clinical interest, and other constraints such as sample size would alter the optimal design of the model observer.

  16. Signal lights - designed light for rear lamps and new upcoming technologies: innovations in automotive lighting

    Science.gov (United States)

    Mügge, Martin; Hohmann, Carsten

    2016-04-01

    Signal functions have to fulfill statutory regulations such as ECE or FMVSS108 to provide a clear signal to other road users and satisfy the same standard definitions of lighting parameters. However, as rear combination lamps are very different from one another, and these days are an increasingly powerful design element of cars, automotive manufacturers want an innovative, superior, and contrasting design. Daytime appearances with a new and unusual look and nighttime appearances with unexpected illumination are strong drivers for developing amazing innovative signal functions. The combination of LED technology and different forms of light-guiding optics, new interpretations of common optical systems to develop various styling options, the use of new materials and components for lighting effects, the introduction of OLED technology on the automotive market, and amazing new optical systems, using diffractive or holographic optics in future rear lamps, are paving the way for further, exciting design possibilities. The challenge of new signal functions is to take these possibilities and to develop the appearance and illumination effects the designer wants to reinforce the image of the car manufacturer and to fit harmoniously into the vehicle design. Lighting systems with a three-dimensional design and appearance when unlit and lit, amazing 3D effects, and surprising lighting scenarios will gain in importance. But the signal lights on cars will, in the future, be not only lighting functions in rear lamps; new functions and stylistic illuminations for coming/leaving-home scenarios will support and complete the car's overall lighting appearance. This paper describes current lighting systems realizing the styling requirements and future lighting systems offering new design possibilities and developing further stylistic, visual effects and improved technologies.

  17. SOLUTION OF SIGNAL UNCERTAINTY PROBLEM AT ANALYTICAL DESIGN OF CONSECUTIVE COMPENSATOR IN PIEZO ACTUATOR CONTROL

    Directory of Open Access Journals (Sweden)

    S.V. Bystrov

    2016-05-01

    Full Text Available Subject of Research.We present research results for the signal uncertainty problem that naturally arises for the developers of servomechanisms, including analytical design of serial compensators, delivering the required quality indexes for servomechanisms. Method. The problem was solved with the use of Besekerskiy engineering approach, formulated in 1958. This gave the possibility to reduce requirements for input signal composition of servomechanisms by using only two of their quantitative characteristics, such as maximum speed and acceleration. Information about input signal maximum speed and acceleration allows entering into consideration the equivalent harmonic input signal with calculated amplitude and frequency. In combination with requirements for maximum tracking error, the amplitude and frequency of the equivalent harmonic effects make it possible to estimate analytically the value of the amplitude characteristics of the system by error and then convert it to amplitude characteristic of open-loop system transfer function. While previously Besekerskiy approach was mainly used in relation to the apparatus of logarithmic characteristics, we use this approach for analytical synthesis of consecutive compensators. Main Results. Proposed technique is used to create analytical representation of "input–output" and "error–output" polynomial dynamic models of the designed system. In turn, the desired model of the designed system in the "error–output" form of analytical representation of transfer functions is the basis for the design of consecutive compensator, that delivers the desired placement of state matrix eigenvalues and, consequently, the necessary set of dynamic indexes for the designed system. The given procedure of consecutive compensator analytical design on the basis of Besekerskiy engineering approach under conditions of signal uncertainty is illustrated by an example. Practical Relevance. The obtained theoretical results are

  18. Bio-signal analysis system design with support vector machines based on cloud computing service architecture.

    Science.gov (United States)

    Shen, Chia-Ping; Chen, Wei-Hsin; Chen, Jia-Ming; Hsu, Kai-Ping; Lin, Jeng-Wei; Chiu, Ming-Jang; Chen, Chi-Huang; Lai, Feipei

    2010-01-01

    Today, many bio-signals such as Electroencephalography (EEG) are recorded in digital format. It is an emerging research area of analyzing these digital bio-signals to extract useful health information in biomedical engineering. In this paper, a bio-signal analyzing cloud computing architecture, called BACCA, is proposed. The system has been designed with the purpose of seamless integration into the National Taiwan University Health Information System. Based on the concept of. NET Service Oriented Architecture, the system integrates heterogeneous platforms, protocols, as well as applications. In this system, we add modern analytic functions such as approximated entropy and adaptive support vector machine (SVM). It is shown that the overall accuracy of EEG bio-signal analysis has increased to nearly 98% for different data sets, including open-source and clinical data sets.

  19. Design and construction of system for telephonic transmission of Ecg signals

    International Nuclear Information System (INIS)

    Moradi, M. H.; Mazloum, J.

    2001-01-01

    With the growing use of Electrocardiogram signal for detection and diagnosis of heart disorders, the efficient transmission of this signal over telephone lines or mobile radio is becoming more and more important. A specialist in a major hospital can use the system and revive information on a patient in a rural area and send back a plan of treatment specific for that patient. In this article, we present different stage for design and fabricate an intelligent telephonic transmission System with 12-Lead Ecg. This paper includes two sections on hardware and software. The digital hardware circuitry takes benefit of an microprocessor. Microprocessor software takes hospital telephone number and transmit/receive serial data to modem. In software section a real algorithm is used to draw Ecg signal and save this digital data to remote computer hard disk and compression Ecg signal via four algorithms

  20. Use of modulated excitation signals in ultrasound. Part II: Design and performance for medical imaging applications

    DEFF Research Database (Denmark)

    Misaridis, Thanassis; Jensen, Jørgen Arendt

    2005-01-01

    For pt.I, see ibid., vol.52, no.2, p.177-91 (2005). In the first paper, the superiority of linear FM signals was shown in terms of signal-to-noise ratio and robustness to tissue attenuation. This second paper in the series of three papers on the application of coded excitation signals in medical...... ultrasound presents design methods of linear FM signals and mismatched filters, in order to meet the higher demands on resolution in ultrasound imaging. It is shown that for the small time-bandwidth (TB) products available in ultrasound, the rectangular spectrum approximation is not valid, which reduces...... to efficiently use the available bandwidth and at the same time to be insensitive to the transducer's impulse response. With these techniques, temporal sidelobes are kept below 60 to 100 dB, image contrast is improved by reducing the energy within the sidelobe region, and axial resolution is preserved...

  1. Design Methodology of a New Wavelet Basis Function for Fetal Phonocardiographic Signals

    Science.gov (United States)

    Chourasia, Vijay S.; Tiwari, Anil Kumar

    2013-01-01

    Fetal phonocardiography (fPCG) based antenatal care system is economical and has a potential to use for long-term monitoring due to noninvasive nature of the system. The main limitation of this technique is that noise gets superimposed on the useful signal during its acquisition and transmission. Conventional filtering may result into loss of valuable diagnostic information from these signals. This calls for a robust, versatile, and adaptable denoising method applicable in different operative circumstances. In this work, a novel algorithm based on wavelet transform has been developed for denoising of fPCG signals. Successful implementation of wavelet theory in denoising is heavily dependent on selection of suitable wavelet basis function. This work introduces a new mother wavelet basis function for denoising of fPCG signals. The performance of newly developed wavelet is found to be better when compared with the existing wavelets. For this purpose, a two-channel filter bank, based on characteristics of fPCG signal, is designed. The resultant denoised fPCG signals retain the important diagnostic information contained in the original fPCG signal. PMID:23766693

  2. Design and Development of VHF Antennas for Space Borne Signal of Opportunity Receivers for Cubesat Platforms

    Science.gov (United States)

    Deshpande, Manohar; Piepmeier, Jeffrey

    2015-01-01

    Design and Development of VHF Antennas for Space Borne Signal of Opportunity Receivers for Cubesat Platforms. Space borne microwave remote sensors at VHF/UHF frequencies are important instruments to observe reflective properties of land surfaces through thick and heavy forestation on a global scale. One of the most cost effective ways of measuring land reflectivity at VHF/UHF frequencies is to use signals transmitted by existing communication satellites (operating at VHF/UHF band) as a signal of opportunity (SoOp) signal and passive receivers integrated with airborne/space borne platforms operating in the Low Earth Orbit (LEO). One of the critical components of the passive receiver is two antennas (one to receive only direct signal and other to receive only reflected signal) which need to have ideally high (>30dB) isolation. However, because of small size of host platforms and broad beam width of dipole antennas, achieving adequate isolation between two channels is a challenging problem and need to be solved for successful implementation of space borne SoOp technology for remote sensing. In this presentation a novel enabling VHF antenna technology for Cubesat platforms is presented to receive direct as well as reflected signal with needed isolation. The novel scheme also allows enhancing the gain of individual channels by factor of 2 without use of reflecting ground plane

  3. Design and Simulation of Electrocardiogram Circuit with Automatic Analysis of ECG Signal

    Directory of Open Access Journals (Sweden)

    Tosin Jemilehin

    2016-10-01

    Full Text Available An electrocardiogram (ECG is the graphical record of bioelectric signal generated by the human body during cardiac cycle, it tells a lot about the medical status of an individual. A typical ECG waveform consist of the P, Q, R, S and T wave. The automatic ECG signal analysis comprises of using computational method/approach in extracting important features and classification of ECG waveform. This paper presents a concise ECG circuit design using an instrumentation amplifier and a band-pass passive filter. It also present the process involved in analysis of ECG signal. The first stage is the pre-filtering stage, followed by feature extraction of the signal. QRS complex is first extracted followed by P and T wave detection, also the FFT of the signal is also extracted. These features are fed into the classifier for proper classification. A pattern recognition neural network is used for classification, prior to the full deployment of the neural network, it is trained by pre-recorded ECG signal downloaded from the MIT/BIH Arrhythmias database. The neural network gave a satisfactory result with accuracy of around 87%.The whole ECG signal analysis is packaged into a MATLAB GUI for ease of use

  4. Designing a Signal Conditioning System with Software Calibration for Resistor-feedback Patch Clamp Amplifier.

    Science.gov (United States)

    Hu, Gang; Zhu, Quanhui; Qu, Anlian

    2005-01-01

    In this paper, a programmable signal conditioning system based on software calibration for resistor-feedback patch clamp amplifier (PCA) has been described, this system is mainly composed of frequency correction, programmable gain and filter whose parameters are configured by software automatically to minimize the errors, A lab-designed data acquisition system (DAQ) is used to implement data collections and communications with PC. The laboratory test results show good agreement with design specifications.

  5. Design and realization of an all-fiber broadband tunable gain equalization filter for DWDM signals.

    Science.gov (United States)

    Varshney, R K; Nagaraju, B; Singh, A; Pal, B P; Kar, A K

    2007-10-17

    Design and fabrication of a tunable gain equalization filter for dense wavelength division multiplexed (DWDM) signals through erbium doped fiber amplifiers (EDFA) is reported. It is based on a side-polished fiber (SPF) half-coupler block loaded with a displaceable tapered multimode overlay waveguide (MMOW). A simple and accurate normal mode analysis is employed to design this filtering device for its subsequent realization. Equalization of a typical EDFA gain spectrum in the C-band within +/-0.35 dB or even less in the presence of various ITU standard C-band DWDM signal channels is demonstrated under varied operating conditions like add/drop of signals. Tunability of the filter notch is achieved through displacement of the SPF relative to the MMOW.

  6. A IF Signal Precessing System Design Based on Software Radio Platform

    Directory of Open Access Journals (Sweden)

    Zhao Jing

    2018-01-01

    Full Text Available Software radio is a definition of a design thought about how to implement flexible functions by using fixed hardware platform. Any platform based on this is characterized to be universal, standardized, modular, open and highly flexible. Due to some realistic reasons, a software radio platform is hard to be realized. So, most signal processing is operated after mixing. According to software radio requirements, a “FPGA+ADC+DAC” structure is designed. Compared with former processors, this module has broad application prospects with the small size, low power, configurable and programmable feathers. It has multifunction, such as generating IF signals, performing digital down conversion and realizing the synchronous demodulation and the other functions. This module also provides the extended host interface to communicate with upper computers. According to the practical test, take MSK signal for example, if the bit rate is 1Mb/s, bit error rate is lower than 10-6.

  7. Designs of precoding for LTE TDD using cell specific reference signals

    DEFF Research Database (Denmark)

    Sun, Fan; Lu, Lu; Sørensen, Troels Bundgaard

    2010-01-01

    We design non-codebook-based Multiple-Input Multiple-Output (MIMO) precoding schemes using multiple cell-specific reference signals patterns for the time division duplex (TDD) mode of LTE, where channel reciprocity can be exploited. Previously proposed non-codebookbased precoding schemes typically...

  8. A design of a valid signal selecting and position decoding ASIC for PET using silicon photomultipliers

    Science.gov (United States)

    Cho, M.; Lim, K.-t.; Kim, H.; Yeom, J.-y.; Kim, J.; Lee, C.; Choi, H.; Cho, G.

    2017-01-01

    In most cases, a PET system has numerous electrical components and channel circuits and thus it would rather be a bulky product. Also, most existing systems receive analog signals from detectors which make them vulnerable to signal distortions. For these reasons, channel reduction techniques are important. In this work, an ASIC for PET module is being proposed. An ASIC chip for 16 PET detector channels, VSSPDC, has been designed and simulated. The main function of the chip is 16-to-1 channel reduction, i.e., finding the position of only the valid signals, signal timing, and magnitudes in all 16 channels at every recorded event. The ASIC comprises four of 4-channel modules and a 2nd 4-to-1 router. A single channel module comprises a transimpedance amplifier for the silicon photomultipliers, dual comparators with high and low level references, and a logic circuitry. While the high level reference was used to test the validity of the signal, the low level reference was used for the timing. The 1-channel module of the ASIC produced an energy pulse by time-over-threshold method and it also produced a time pulse with a fixed delayed time. Since the ASIC chip outputs only a few digital pulses and does not require an external clock, it has an advantage over noise properties. The cadence simulation showed the good performance of the chip as designed.

  9. A design of a valid signal selecting and position decoding ASIC for PET using silicon photomultipliers

    International Nuclear Information System (INIS)

    Cho, M.; Lim, K.-T.; Kim, J.; Lee, C.; Cho, G.; Kim, H.; Yeom, J.-Y.; Choi, H.

    2017-01-01

    In most cases, a PET system has numerous electrical components and channel circuits and thus it would rather be a bulky product. Also, most existing systems receive analog signals from detectors which make them vulnerable to signal distortions. For these reasons, channel reduction techniques are important. In this work, an ASIC for PET module is being proposed. An ASIC chip for 16 PET detector channels, VSSPDC, has been designed and simulated. The main function of the chip is 16-to-1 channel reduction, i.e., finding the position of only the valid signals, signal timing, and magnitudes in all 16 channels at every recorded event. The ASIC comprises four of 4-channel modules and a 2 nd 4-to-1 router. A single channel module comprises a transimpedance amplifier for the silicon photomultipliers, dual comparators with high and low level references, and a logic circuitry. While the high level reference was used to test the validity of the signal, the low level reference was used for the timing. The 1-channel module of the ASIC produced an energy pulse by time-over-threshold method and it also produced a time pulse with a fixed delayed time. Since the ASIC chip outputs only a few digital pulses and does not require an external clock, it has an advantage over noise properties. The cadence simulation showed the good performance of the chip as designed.

  10. The effects of advanced digital signal processing concepts on VLSIC/VHSIC design

    Science.gov (United States)

    Jankowski, C.

    Implementations of sophisticated mathematical techniques in advanced digital signal processors can significantly improve performance. Future VLSI and VHSI circuit designs must include the practical realization of these algorithms. A structured design approach is described and illustrated with examples from a RNS FIR filter processor development project. The CAE hardware and software required to support tasks of this complexity are also discussed. An EWS is recommended for controlling essential functions such as logic optimization, simulation and verification. The total IC design system is illustrated with the implementation of a new high performance algorithm for computing complex magnitude.

  11. Designing Non-linear Frequency Modulated Signals For Medical Ultrasound Imaging

    DEFF Research Database (Denmark)

    Gran, Fredrik; Jensen, Jørgen Arendt

    2006-01-01

    In this paper a new method for designing non-linear frequency modulated (NLFM) waveforms for ultrasound imaging is proposed. The objective is to control the amplitude spectrum of the designed waveform and still keep a constant transmit amplitude, so that the transmitted energy is maximized...... is tested experimentally using the RASMUS ultrasound system with a 7 MHz linear array transducer. Synthetic transmit aperture ultrasound imaging is applied to acquire data. The proposed design method was compared to a linear FM signal. Due to more efficient spectral usage, a gain in SNR of 4.3plusmn1.2 d...

  12. Decentralized Hierarchical Controller Design for Selective Damping of Inter Area Oscillations Using PMU Signals

    Directory of Open Access Journals (Sweden)

    Ashfaque Ahmed Hashmani

    2011-07-01

    Full Text Available This paper deals with the decentralized hierarchical PSS (Power System Stabilizer controller design to achieve a better damping of specific inter-area oscillations. The two-level decentralized hierarchical structure consists of two PSS controllers. The first level controller is a local PSS controller for each generator to damp local mode in the area where controller is located. This controller uses only local signals as input signals. The local signal comes from the generator at which the controller is located. The secondary level controller is a multivariable decentralized global PSS controller to damp inter-area modes. This controller uses selected suitable wide area PMU (Phasor Measurement Units signals as inputs. The PMU or global signals are taken from network locations where the oscillations are well observable. The global controller uses only those global input signals in which the assigned single inter-area mode is most observable and is located at a generator that is most effective in controlling the assigned mode. The global controller works mainly in a frequency band given by the natural frequency of the assigned mode. The effectiveness of the resulting hierarchical controller is demonstrated through simulation studies conducted on a test power system.

  13. A self-organizing algorithm for vector quantizer design applied to signal processing.

    Science.gov (United States)

    Madeiro, F; Vilar, R M; Fechine, J M; Neto, B G

    1999-06-01

    Vector quantization plays an important role in many signal processing problems, such as speech/speaker recognition and signal compression. This paper presents an unsupervised algorithm for vector quantizer design. Although the proposed method is inspired in Kohonen learning, it does not incorporate the classical definition of topological neighborhood as an array of nodes. Simulations are carried out to compare the performance of the proposed algorithm, named SOA (self-organizing algorithm), to that of the traditional LBG (Linde-Buzo-Gray) algorithm. The authors present an evaluation concerning the codebook design for Gauss-Markov and Gaussian sources, since the theoretic optimal performance bounds for these sources, as described by Shannon's Rate-Distortion Theory, are known. In speech and image compression, SOA codebooks lead to reconstructed (vector-quantized) signals with better quality as compared to the ones obtained by using LBG codebooks. Additionally, the influence of the initial codebook in the algorithm performance is investigated and the algorithm ability to learn representative patterns is evaluated. In a speaker identification system, it is shown that the the codebooks designed by SOA lead to higher identification rates when compared to the ones designed by LBG.

  14. Apollo experience report: S-band system signal design and analysis

    Science.gov (United States)

    Rosenberg, H. R. (Editor)

    1972-01-01

    A description is given of the Apollo communications-system engineering-analysis effort that ensured the adequacy, performance, and interface compatibility of the unified S-band system elements for a successful lunar-landing mission. The evolution and conceptual design of the unified S-band system are briefly reviewed from a historical viewpoint. A comprehensive discussion of the unified S-band elements includes the salient design features of the system and serves as a basis for a better understanding of the design decisions and analyses. The significant design decisions concerning the Apollo communications-system signal design are discussed providing an insight into the role of systems analysis in arriving at the current configuration of the Apollo communications system. Analyses are presented concerning performance estimation (mathematical-model development through real-time mission support) and system deficiencies, modifications, and improvements.

  15. Pilot Signal Design and Direct Ranging Methods for Radio Localization Using OFDM Systems

    DEFF Research Database (Denmark)

    Jing, Lishuai

    Having accurate localization capability is becoming important for existing and future terrestrial wireless communication systems, in particular for orthogonal frequency-division multiplexing (OFDM) systems, such as WiMAX, wireless local area network, long-term evolution (LTE) and its extension LTE......-Advanced. To obtain accurate position estimates, not only advanced estimation algorithms are needed but also the transmitted signals should be scrutinized. In this dissertation, we investigate how to design OFDM pilot signals and propose and evaluate high accuracy ranging techniques with tractable computational....... For scenarios where the number of path components is unknown and these components are not necessary separable, we propose a direct ranging technique using the received frequency-domain OFDM pilot signals. Compared to conventional (two-step) ranging methods, which estimate intermediate parameters...

  16. Equalizer design for clock recovery based on multi-level optical disk using signal waveform modulation

    Science.gov (United States)

    Shao, Meng; Pei, Jing; Yang, Bo

    2013-12-01

    With smaller pits and lands in multi-level optical disks using signal waveform modulation than those in DVD disks, the ISI and nonlinear attenuation of the read-out signal become more serious. One ordinary way is using an equalizer at sample rate 1/T, we proposed one method of designing the equalizer in fixed sample rate with digital interpolation. According to the analysis of the multi-level optical disk channel, we get the target frequency-response cure and implement it with seven order FIR filter. From the result of the read out experiment with multi-level optical disk, the clock of the RF signal could be recovered with the proposed equalizer.

  17. Design of a modular signal processing board (MSPB) for gamma-ray imaging applications

    Energy Technology Data Exchange (ETDEWEB)

    Bieberle, A., E-mail: A.Bieberle@hzdr.de [Helmholtz-Zentrum Dresden-Rossendorf, Institute of Safety Research, Bautzner Landstrasse 400, 01328 Dresden (Germany); Berger, R.; Yadav, R.; Schleicher, E.; Hampel, U. [Helmholtz-Zentrum Dresden-Rossendorf, Institute of Safety Research, Bautzner Landstrasse 400, 01328 Dresden (Germany)

    2012-01-21

    In this paper a new modular signal processing board (MSPB) for high-resolution gamma-ray computed tomography (GCT) is presented. The MSPB is optimised for parallel signal processing of eight detector channels operating in pulse counting mode. Signal processing stages comprise of variable gain amplifiers, pulse height discrimination stages, 13-bit counters with corresponding latches as well as logic circuitry for coordinated data transfer with a multitude of MSPBs. The digital signal processing units are realised in commercially available complex programmable logic devices (CPLD). Each MSPB is addressable by an 8-bit DIP-switch, which allows the use of up to 256 modules or 2048 detector pixels within one detector system. The geometry of the MSPB allows a multiple and seamless detector module arrangement, which eases the adaptation of a given gamma-ray detector system to specific industrial and laboratory applications. The choice of the electronic devices and the thermal design was optimised for low power consumption in order to minimise internal heat production, which would affect the characteristics of the detector's intrinsic gain strongly. Thermal measurements have been executed to prove the functionality of the thermal design.

  18. Design of a modular signal processing board (MSPB) for gamma-ray imaging applications

    Science.gov (United States)

    Bieberle, A.; Berger, R.; Yadav, R.; Schleicher, E.; Hampel, U.

    2012-01-01

    In this paper a new modular signal processing board (MSPB) for high-resolution gamma-ray computed tomography (GCT) is presented. The MSPB is optimised for parallel signal processing of eight detector channels operating in pulse counting mode. Signal processing stages comprise of variable gain amplifiers, pulse height discrimination stages, 13-bit counters with corresponding latches as well as logic circuitry for coordinated data transfer with a multitude of MSPBs. The digital signal processing units are realised in commercially available complex programmable logic devices (CPLD). Each MSPB is addressable by an 8-bit DIP-switch, which allows the use of up to 256 modules or 2048 detector pixels within one detector system. The geometry of the MSPB allows a multiple and seamless detector module arrangement, which eases the adaptation of a given gamma-ray detector system to specific industrial and laboratory applications. The choice of the electronic devices and the thermal design was optimised for low power consumption in order to minimise internal heat production, which would affect the characteristics of the detector's intrinsic gain strongly. Thermal measurements have been executed to prove the functionality of the thermal design.

  19. A high precision position sensor design and its signal processing algorithm for a maglev train.

    Science.gov (United States)

    Xue, Song; Long, Zhiqiang; He, Ning; Chang, Wensen

    2012-01-01

    High precision positioning technology for a kind of high speed maglev train with an electromagnetic suspension (EMS) system is studied. At first, the basic structure and functions of the position sensor are introduced and some key techniques to enhance the positioning precision are designed. Then, in order to further improve the positioning signal quality and the fault-tolerant ability of the sensor, a new kind of discrete-time tracking differentiator (TD) is proposed based on nonlinear optimal control theory. This new TD has good filtering and differentiating performances and a small calculation load. It is suitable for real-time signal processing. The stability, convergence property and frequency characteristics of the TD are studied and analyzed thoroughly. The delay constant of the TD is figured out and an effective time delay compensation algorithm is proposed. Based on the TD technology, a filtering process is introduced in to improve the positioning signal waveform when the sensor is under bad working conditions, and a two-sensor switching algorithm is designed to eliminate the positioning errors caused by the joint gaps of the long stator. The effectiveness and stability of the sensor and its signal processing algorithms are proved by the experiments on a test train during a long-term test run.

  20. A High Precision Position Sensor Design and Its Signal Processing Algorithm for a Maglev Train

    Directory of Open Access Journals (Sweden)

    Wensen Chang

    2012-04-01

    Full Text Available High precision positioning technology for a kind of high speed maglev train with an electromagnetic suspension (EMS system is studied. At first, the basic structure and functions of the position sensor are introduced and some key techniques to enhance the positioning precision are designed. Then, in order to further improve the positioning signal quality and the fault-tolerant ability of the sensor, a new kind of discrete-time tracking differentiator (TD is proposed based on nonlinear optimal control theory. This new TD has good filtering and differentiating performances and a small calculation load. It is suitable for real-time signal processing. The stability, convergence property and frequency characteristics of the TD are studied and analyzed thoroughly. The delay constant of the TD is figured out and an effective time delay compensation algorithm is proposed. Based on the TD technology, a filtering process is introduced in to improve the positioning signal waveform when the sensor is under bad working conditions, and a two-sensor switching algorithm is designed to eliminate the positioning errors caused by the joint gaps of the long stator. The effectiveness and stability of the sensor and its signal processing algorithms are proved by the experiments on a test train during a long-term test run.

  1. Design of human controlled 1 DOF right hand exoskeleton using electromyography signal

    Science.gov (United States)

    Azzam, M.; Wijaya, S. K.; Prawito

    2017-07-01

    Exoskeleton in general is a structure that is anatomically designed to be able to accommodate the physical movement of its user and provide additional strength. The use of EMG signal to control a 1 DOF right arm exoskeleton is evaluated in this research. This research aims to achieve optimum control using EMG signal. EMG signal is a variation of voltage that occurs when muscle contracts hence its strong correlation with the user's intention of movement. The RMS values of each EMG signal that originates from bicep and tricep muscle are calculated and processed to determine the direction and speed of rotation of a DC motor that actuates the exoskeleton. The RMS calculation is conducted at various array length that will theoretically affect its accuracy. The difference between those two RMS values is then calculated and interpreted as the intention of flexion or extension movement that will control the DC motor rotational direction. The absolute value of the RMS difference multiplied with a gain factor is used to regulate the duty cycle of a PWM signal that is used to control the rotational speed of the DC motor. To achieve the smallest settling time, array length and gain factor were varied. The test was conducted in two stages, static and dynamic tests. The test result shows a trend where the settling time decreases when array length is shortened and gain is increased. It shows that optimum control can be achieved by selecting the right array length and gain.

  2. Novel textile systems for the continuous monitoring of vital signals: design and characterization.

    Science.gov (United States)

    Trindade, Isabel G; Martins, Frederico; Dias, Rúben; Oliveira, Cristina; Machado da Silva, José

    2015-08-01

    In this article we present a smart textile system for the continuous monitoring of cardiorespiratory signals, produced and integrated with an industrial embroidery unit. The design of a T-shirt system, having embedded textile sensors and interconnects and custom designed circuit for data collection and Bluetooth transmission is presented. The performance of skin-contact textile electrodes, having distinctive electrical characteristics and surface morphologies, was characterized by measurements of signal to noise ratio, under dry and moisture conditions. The influence of the electrodes size and the wear resistance were addressed. Results of an electrocardiogram acquisition with a subject wearing the T-shirt and display on a smartphone are also shown. The presented smart textile systems exhibit good performance and versatility for custom demand production.

  3. Design Navigation Computer System Based on Double Digital Signal Process and FPGA

    Directory of Open Access Journals (Sweden)

    Jie Yan

    2013-03-01

    Full Text Available The article describes the design and implementation of integrated navigation embedded computer system based on double DSP and FPGA. In the system, TMS320C6727 (C6727 and TMS320C6713 (C6713 digital signal processor (DSP, which produced by TI are used as the core processing chip. C6727 is responsibility to de-noising the inertial measurement unit (IMU original signal, and send the IMU data to C6713. C6713 is responsibility to collect the IMU and GNSS data, run navigation algorithm and send the navigation information to other implements. The I/0 interface, timing control, data buffering and address bus decoding modes are implemented in FPGA. This design can improve the system real-time performance and reliability.

  4. The conservation value of elevation data accuracy and model sophistication in reserve design under sea-level rise.

    Science.gov (United States)

    Zhu, Mingjian; Hoctor, Tom; Volk, Mike; Frank, Kathryn; Linhoss, Anna

    2015-10-01

    Many studies have explored the value of using more sophisticated coastal impact models and higher resolution elevation data in sea-level rise (SLR) adaptation planning. However, we know little about to what extent the improved models and data could actually lead to better conservation outcomes under SLR. This is important to know because high-resolution data are likely to not be available in some data-poor coastal areas in the world and running more complicated coastal impact models is relatively time-consuming, expensive, and requires assistance by qualified experts and technicians. We address this research question in the context of identifying conservation priorities in response to SLR. Specifically, we investigated the conservation value of using more accurate light detection and ranging (Lidar)-based digital elevation data and process-based coastal land-cover change models (Sea Level Affecting Marshes Model, SLAMM) to identify conservation priorities versus simple "bathtub" models based on the relatively coarse National Elevation Dataset (NED) in a coastal region of northeast Florida. We compared conservation outcomes identified by reserve design software (Zonation) using three different model dataset combinations (Bathtub-NED, Bathtub-Lidar, and SLAMM-Lidar). The comparisons show that the conservation priorities are significantly different with different combinations of coastal impact models and elevation dataset inputs. The research suggests that it is valuable to invest in more accurate coastal impact models and elevation datasets in SLR adaptive conservation planning because this model-dataset combination could improve conservation outcomes under SLR. Less accurate coastal impact models, including ones created using coarser Digital Elevation Model (DEM) data can still be useful when better data and models are not available or feasible, but results need to be appropriately assessed and communicated. A future research priority is to investigate how

  5. Design of a novel biomedical signal processing and analysis tool for functional neuroimaging.

    Science.gov (United States)

    Kaçar, Sezgin; Sakoğlu, Ünal

    2016-03-01

    In this paper, a MATLAB-based graphical user interface (GUI) software tool for general biomedical signal processing and analysis of functional neuroimaging data is introduced. Specifically, electroencephalography (EEG) and electrocardiography (ECG) signals can be processed and analyzed by the developed tool, which incorporates commonly used temporal and frequency analysis methods. In addition to common methods, the tool also provides non-linear chaos analysis with Lyapunov exponents and entropies; multivariate analysis with principal and independent component analyses; and pattern classification with discriminant analysis. This tool can also be utilized for training in biomedical engineering education. This easy-to-use and easy-to-learn, intuitive tool is described in detail in this paper. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  6. Ground state robustness as an evolutionary design principle in signaling networks.

    Directory of Open Access Journals (Sweden)

    Onder Kartal

    Full Text Available The ability of an organism to survive depends on its capability to adapt to external conditions. In addition to metabolic versatility and efficient replication, reliable signal transduction is essential. As signaling systems are under permanent evolutionary pressure one may assume that their structure reflects certain functional properties. However, despite promising theoretical studies in recent years, the selective forces which shape signaling network topologies in general remain unclear. Here, we propose prevention of autoactivation as one possible evolutionary design principle. A generic framework for continuous kinetic models is used to derive topological implications of demanding a dynamically stable ground state in signaling systems. To this end graph theoretical methods are applied. The index of the underlying digraph is shown to be a key topological property which determines the so-called kinetic ground state (or off-state robustness. The kinetic robustness depends solely on the composition of the subdigraph with the strongly connected components, which comprise all positive feedbacks in the network. The component with the highest index in the feedback family is shown to dominate the kinetic robustness of the whole network, whereas relative size and girth of these motifs are emphasized as important determinants of the component index. Moreover, depending on topological features, the maintenance of robustness differs when networks are faced with structural perturbations. This structural off-state robustness, defined as the average kinetic robustness of a network's neighborhood, turns out to be useful since some structural features are neutral towards kinetic robustness, but show up to be supporting against structural perturbations. Among these are a low connectivity, a high divergence and a low path sum. All results are tested against real signaling networks obtained from databases. The analysis suggests that ground state robustness may

  7. A Flexible Modulation Scheme Design for C-Band GNSS Signals

    Directory of Open Access Journals (Sweden)

    Rui Xue

    2015-01-01

    Full Text Available Due to the spectrum congestion of current navigation signals in L-band, C-band has been taken into consideration as a candidate frequency band for global navigation satellite system (GNSS. As is known, modulation scheme is the core part of signal structure, and how to design a modulation waveform that could make full use of narrow bandwidth 20 MHz and satisfy the constraint condition of frequency compatibility in C-band is the main research content of this paper. In view of transmission characteristics and constraint condition of compatibility in C-band, multi-h continuous phase modulation (CPM is proposed as a candidate modulation scheme. Then the classical channel capacity estimation and a comprehensive evaluation criterion for GNSS modulation signals are employed to assess the proposed scheme in the aspects of the capacity over additive white Gaussian noise (AWGN, tracking accuracy, multipath mitigation, antijamming, and so on. Simulation results reveal that, through optimizing the number and size of modulation indexes, the flexible scheme could offer better performance in terms of code tracking, multipath mitigation, and antijamming compared with other candidates such as MSK and GMSK while maintaining high band efficiency and moderate implementation complexity of receiver. Moreover, this paper also provides a reference for next generation modulation signals in C-band.

  8. Design and Evaluation of Novel Textile Wearable Systems for the Surveillance of Vital Signals

    Directory of Open Access Journals (Sweden)

    Isabel G. Trindade

    2016-09-01

    Full Text Available This article addresses the design, development, and evaluation of T-shirt prototypes that embed novel textile sensors for the capture of cardio and respiratory signals. The sensors are connected through textile interconnects to either an embedded custom-designed data acquisition and transmission unit or to snap fastener terminals for connection to external monitoring devices. The performance of the T-shirt prototype is evaluated in terms of signal-to-noise ratio amplitude and signal interference caused by baseline wander and motion artefacts, through laboratory tests with subjects in standing and walking conditions. Performance tests were also conducted in a hospital environment using a T-shirt prototype connected to a commercial three-channel Holter monitoring device. The textile sensors and interconnects were realized with the assistance of an industrial six-needle digital embroidery tool and their resistance to wear addressed with normalized tests of laundering and abrasion. The performance of these wearable systems is discussed, and pathways and methods for their optimization are highlighted.

  9. Design and Realization of a New Signal Security System for Multimedia Data Transmission

    Directory of Open Access Journals (Sweden)

    Hun-Chen Chen

    2003-12-01

    Full Text Available We propose a new signal security system and its VLSI architecture for real-time multimedia data transmission applications. We first define two bit-circulation functions for one-dimensional binary array transformation. Then, we exploit a chaotic system in generating a binary sequence to control the bit-circulation functions defined for performing the successive transformation on the input data. Each eight 8-bit data elements is regarded as a set and is fed into an 8×8 binary matrix being transformed on each row and each column of the matrix by these two bit-circulation functions such that the signal can be transformed into completely disordered data. The features of the proposed design include low computational complexity, regular operations suitable for low-cost VLSI implementation, high data security, and high feasibility for easy integration with commercial multimedia storage and transmission applications. We have performed Matlab simulation to verify the functional correctness of the proposed system. In implementing the system, a low-cost VLSI architecture has been designed, verified, and physically realized based on a 0.35 μm CMOS technology. The implementation results show that the proposed signal security system can achieve 117 Mbytes/s data throughput rate that is fast enough for real-time data protection in multimedia transmission applications.

  10. The Design of Wireless Data Acquisition and Remote Transmission Interface in Micro-seismic Signals

    Directory of Open Access Journals (Sweden)

    Huan-Huan BIAN

    2014-02-01

    Full Text Available The micro-seismic signal acquisition and transmission is an important key part in geological prospecting. This paper describes a bran-new solution of micro-seismic signal acquisition and remote transmission using Zigbee technique and wireless data transmission technique. The hardware such as front-end data acquisition interface made up by Zigbee wireless networking technique, remote data transmission solution composed of general packet radio service (or GPRS for short technique and interface between Zigbee and GPRS is designed in detail. Meanwhile the corresponding software of the system is given out. The solution solves the numerous practical problems nagged by complex and terrible environment faced using micro-seismic prospecting. The experimental results demonstrate that the method using Zigbee wireless network communication technique GPRS wireless packet switching technique is efficient, reliable and flexible.

  11. MIMO Radar Transceiver Design for High Signal-to-Interference-Plus-Noise Ratio

    KAUST Repository

    Lipor, John

    2013-05-12

    Multiple-input multiple-output (MIMO) radar employs orthogonal or partially correlated transmit signals to achieve performance benefits over its phased-array counterpart. It has been shown that MIMO radar can achieve greater spatial resolution, improved signal-to-noise ratio (SNR) and target localization, and greater clutter resolution using space-time adaptive processing (STAP). This thesis explores various methods to improve the signal-to-interference-plus-noise ratio (SINR) via transmit and receive beamforming. In MIMO radar settings, it is often desirable to transmit power only to a given location or set of locations defined by a beampattern. Current methods involve a two- step process of designing the transmit covariance matrix R via iterative solutions and then using R to generate waveforms that fulfill practical constraints such as having a constant-envelope or drawing from a finite alphabet. In this document, a closed- form method to design R is proposed that utilizes the discrete Fourier transform (DFT) coefficients and Toeplitz matrices. The resulting covariance matrix fulfills the practical constraints such as positive semidefiniteness and the uniform elemental power constraint and provides performance similar to that of iterative methods, which require a much greater computation time. Next, a transmit architecture is presented 
that exploits the orthogonality of frequencies at discrete DFT values to transmit a sum of orthogonal signals from each antenna. The resulting waveforms provide a lower mean-square error than current methods at a much lower computational cost, and a simulated detection scenario demonstrates the performance advantages achieved. It is also desirable to receive signal power only from a given set of directions defined by a beampattern. In a later chapter of this document, the problem of receive beampattern matching is formulated and three solutions to this problem are demonstrated. We show that partitioning the received data vector

  12. The integrated design and archive of space-borne signal processing and compression coding

    Science.gov (United States)

    He, Qiang-min; Su, Hao-hang; Wu, Wen-bo

    2017-10-01

    With the increasing demand of users for the extraction of remote sensing image information, it is very urgent to significantly enhance the whole system's imaging quality and imaging ability by using the integrated design to achieve its compact structure, light quality and higher attitude maneuver ability. At this present stage, the remote sensing camera's video signal processing unit and image compression and coding unit are distributed in different devices. The volume, weight and consumption of these two units is relatively large, which unable to meet the requirements of the high mobility remote sensing camera. This paper according to the high mobility remote sensing camera's technical requirements, designs a kind of space-borne integrated signal processing and compression circuit by researching a variety of technologies, such as the high speed and high density analog-digital mixed PCB design, the embedded DSP technology and the image compression technology based on the special-purpose chips. This circuit lays a solid foundation for the research of the high mobility remote sensing camera.

  13. Design, development and implementation of the IR signaling techniques for monitoring ambient and body temperature

    International Nuclear Information System (INIS)

    Baqai, A.

    2014-01-01

    Healthcare systems such as hospitals, homecare, telemedicine, and physical rehabilitation are expected to be revolutionized by WBAN (Wireless Body Area Networks). This research work aims to investigate, design, optimize, and demonstrate the applications of IR (Infra-Red) communication systems in WBAN. It is aimed to establish a prototype WBAN system capable of measuring Ambient and Body Temperature using LM35 as temperature sensor and transmitting and receiving the data using optical signals. The corresponding technical challenges that have to be faced are also discussed in this paper. Investigations are carried out to efficiently design the hardware using low-cost and low power optical transceivers. The experimental results reveal the successful transmission and reception of Ambient and Body Temperatures over short ranges i.e. up to 3-4 meters. A simple IR transceiver with an LED (Light Emitting Diodes), TV remote control IC and Arduino microcontroller is designed to perform the transmission with sufficient accuracy and ease. Experiments are also performed to avoid interference from other sources like AC and TV remote control signals by implementing IR tags. (author)

  14. A SystemC-Based Design Methodology for Digital Signal Processing Systems

    Directory of Open Access Journals (Sweden)

    Christian Haubelt

    2007-03-01

    Full Text Available Digital signal processing algorithms are of big importance in many embedded systems. Due to complexity reasons and due to the restrictions imposed on the implementations, new design methodologies are needed. In this paper, we present a SystemC-based solution supporting automatic design space exploration, automatic performance evaluation, as well as automatic system generation for mixed hardware/software solutions mapped onto FPGA-based platforms. Our proposed hardware/software codesign approach is based on a SystemC-based library called SysteMoC that permits the expression of different models of computation well known in the domain of digital signal processing. It combines the advantages of executability and analyzability of many important models of computation that can be expressed in SysteMoC. We will use the example of an MPEG-4 decoder throughout this paper to introduce our novel methodology. Results from a five-dimensional design space exploration and from automatically mapping parts of the MPEG-4 decoder onto a Xilinx FPGA platform will demonstrate the effectiveness of our approach.

  15. Design of pulse oximetry signal based on personal computer for detection oxygen saturation

    International Nuclear Information System (INIS)

    Umi Salamah; Margi Sasono

    2015-01-01

    The lack or excess of oxygen in the blood will cause healthy and body system disorder. At certain level, the disease can lead to death. For that reason, the information about oxygen saturation in blood becomes important to be identified. One of the devices used to monitor the blood oxygen saturation is pulse oximetry. This research attempt to designed Pulse Oximetry based on personal computer using red LED and infrared as its light source, while the light sensor using photodiode. The designed Pulse Oximetry is a non-invasive instrumentation which LED drivers is placed on the fingertips. The LED light goes through the finger will be a signal that is fed to the photodiode and will be converted into digital signals by ADC (Analog to Digital Converter) and will be processed further by a personal computer to display the pulse oximetry graphics. This study uses Delphi 7, Microsoft Excel, and Mt Lab as its software.This designed pulse oximetry has been tested in two peoples: sample A, male 38 years; and sample B, a woman 23 years old. Oxygen saturation of sample A is 80.75, while the sample B is 90.75. (author)

  16. Design of Accelerated Reliability Test for CNC Motorized Spindle Based on Vibration Signal

    Directory of Open Access Journals (Sweden)

    Chen Chao

    2016-01-01

    Full Text Available Motorized spindle is the key functional component of CNC machining centers which is a mechatronics system with long life and high reliability. The reliability test cycle of motorized spindle is too long and infeasible. This paper proposes a new accelerated test for reliability evaluation of motorized spindle. By field reliability test, authors collect and calculate the load data including rotational speed, cutting force and torque. Load spectrum distribution law is analyzed. And authors design a test platform to apply the load spectrum. A new method to define the fuzzy acceleration factor based on the vibration signal is proposed. Then the whole test plan of accelerated reliability test is done.

  17. Optimal design of a bank of spatio-temporal filters for EEG signal classification.

    Science.gov (United States)

    Higashi, Hiroshi; Tanaka, Toshihisa

    2011-01-01

    The spatial weights for electrodes called common spatial pattern (CSP) are known to be effective in EEG signal classification for motor imagery based brain computer interfaces (MI-BCI). To achieve accurate classification in CSP, the frequency filter should be properly designed. To this end, several methods for designing the filter have been proposed. However, the existing methods cannot consider plural brain activities described with different frequency bands and different spatial patterns such as activities of mu and beta rhythms. In order to efficiently extract these brain activities, we propose a method to design plural filters and spatial weights which extract desired brain activity. The proposed method designs finite impulse response (FIR) filters and the associated spatial weights by optimization of an objective function which is a natural extension of CSP. Moreover, we show by a classification experiment that the bank of FIR filters which are designed by introducing an orthogonality into the objective function can extract good discriminative features. Moreover, the experiment result suggests that the proposed method can automatically detect and extract brain activities related to motor imagery.

  18. Signal acquisition module design for multi-channel surface magnetic resonance sounding system.

    Science.gov (United States)

    Lin, Tingting; Chen, Wuqiang; Du, Wenyuan; Zhao, Jing

    2015-11-01

    To obtain a precise 2D/3D image of fissure or karst water, multi-channel magnetic resonance sounding (MRS) systems using edge-to-edge or overlapping receiving coils are needed. Thus, acquiring a nano-volt signal for a small amount of the aquifer and suppressing the mutual coupling between adjacent coils are two important issues for the design of the signal acquisition module in the system. In the present study, we propose to use a passive low pass filter, consisted of a resistance (R) and capacitance (C), to inhibit the mutual coupling effects of the coils. Four low-noise operational amplifiers LT1028, OPA124, AD745, and OP27 were compared with respect to achieving the lowest system noise. As a result, 3 pieces of LT1028 were chosen and connected in parallel to serve as preamplifier, with a sensitivity of 1.4 nV/√Hz at 2 kHz. Experimental results are presented for 2D MRS groundwater investigations conducted in the suburb of Changchun, China. The inversion result is consistent with the result of drilling log, suggesting that the signal acquisition module is well developed.

  19. The design of photoelectric signal processing system for a nuclear magnetic resonance gyroscope based on FPGA

    Science.gov (United States)

    Zhang, Xian; Zhou, Binquan; Li, Hong; Zhao, Xinghua; Mu, Weiwei; Wu, Wenfeng

    2017-10-01

    Navigation technology is crucial to the national defense and military, which can realize the measurement of orientation, positioning, attitude and speed for moving object. Inertial navigation is not only autonomous, real-time, continuous, hidden, undisturbed but also no time-limited and environment-limited. The gyroscope is the core component of the inertial navigation system, whose precision and size are the bottleneck of the performance. However, nuclear magnetic resonance gyroscope is characteristic of the advantage of high precision and small size. Nuclear magnetic resonance gyroscope can meet the urgent needs of high-tech weapons and equipment development of new generation. This paper mainly designs a set of photoelectric signal processing system for nuclear magnetic resonance gyroscope based on FPGA, which process and control the information of detecting laser .The photoelectric signal with high frequency carrier is demodulated by in-phase and quadrature demodulation method. Finally, the processing system of photoelectric signal can compensate the residual magnetism of the shielding barrel and provide the information of nuclear magnetic resonance gyroscope angular velocity.

  20. The Solar Probe Plus Radio Frequency Spectrometer: Measurement requirements, analog design, and digital signal processing

    Science.gov (United States)

    Pulupa, M.; Bale, S. D.; Bonnell, J. W.; Bowen, T. A.; Carruth, N.; Goetz, K.; Gordon, D.; Harvey, P. R.; Maksimovic, M.; Martínez-Oliveros, J. C.; Moncuquet, M.; Saint-Hilaire, P.; Seitz, D.; Sundkvist, D.

    2017-03-01

    The Radio Frequency Spectrometer (RFS) is a two-channel digital receiver and spectrometer, which will make remote sensing observations of radio waves and in situ measurements of electrostatic and electromagnetic fluctuations in the solar wind. A part of the FIELDS suite for Solar Probe Plus (SPP), the RFS is optimized for measurements in the inner heliosphere, where solar radio bursts are more intense and the plasma frequency is higher compared to previous measurements at distances of 1 AU or greater. The inputs to the RFS receiver are the four electric antennas mounted near the front of the SPP spacecraft and a single axis of the SPP search coil magnetometer (SCM). Each RFS channel selects a monopole or dipole antenna input, or the SCM input, via multiplexers. The primary data products from the RFS are autospectra and cross spectra from the selected inputs. The spectra are calculated using a polyphase filter bank, which enables the measurement of low amplitude signals of interest in the presence of high-amplitude narrowband noise generated by spacecraft systems. We discuss the science signals of interest driving the RFS measurement objectives, describe the RFS analog design and digital signal processing, and show examples of current performance.

  1. Design, development and test of the gearbox condition monitoring system using sound signal processing

    Directory of Open Access Journals (Sweden)

    M Zamani

    2016-09-01

    Full Text Available Introduction One of the ways used for minimizing the cost of maintenance and repairs of rotating industrial equipment is condition monitoring using acoustic analysis. One of the most important problems which always have been under consideration in industrial equipment application is confidence possibility. Each dynamic, electrical, hydraulic or thermal system has certain characteristics which show the normal condition of the machine during function. Any changes of the characteristics can be a signal of a problem in the machine. The aim of condition monitoring is system condition determination using measurements of the signals of characteristics and using this information for system impairment prognostication. There are a lot of ways for condition monitoring of different systems, but sound analysis is accepted and used extensively as a method for condition investigation of rotating machines. The aim of this research is the design and construction of considered gearbox and using of obtaining data in frequency and time spectrum in order to analyze the sound and diagnosis. Materials and Methods This research was conducted at the department of mechanical biosystem workshop at Aboureihan College at Tehran University in February 15th.2015. In this research, in order to investigate the trend of diagnosis and gearbox condition, a system was designed and then constructed. The sound of correct and damaged gearbox was investigated by audiometer and stored in computer for data analysis. Sound measurement was done in three pinions speed of 749, 1050 and 1496 rpm and for correct gearboxes, damage of the fracture of a tooth and a tooth wear. Gearbox design and construction: In order to conduct the research, a gearbox with simple gearwheels was designed according to current needs. Then mentioned gearbox and its accessories were modeled in CATIA V5-R20 software and then the system was constructed. Gearbox is a machine that is used for mechanical power transition

  2. Performance Bounds on Micro-Doppler Estimation and Adaptive Waveform Design Using OFDM Signals

    Energy Technology Data Exchange (ETDEWEB)

    Sen, Satyabrata [ORNL; Barhen, Jacob [ORNL; Glover, Charles Wayne [ORNL

    2014-01-01

    We analyze the performance of a wideband orthogonal frequency division multiplexing (OFDM) signal in estimating the micro-Doppler frequency of a target having multiple rotating scatterers (e.g., rotor blades of a helicopter, propellers of a submarine). The presence of rotating scatterers introduces Doppler frequency modulation in the received signal by generating sidebands about the transmitted frequencies. This is called the micro-Doppler effects. The use of a frequency-diverse OFDM signal in this context enables us to independently analyze the micro-Doppler characteristics with respect to a set of orthogonal subcarrier frequencies. Therefore, to characterize the accuracy of micro-Doppler frequency estimation, we compute the Cram er-Rao Bound (CRB) on the angular-velocity estimate of the target while considering the scatterer responses as deterministic but unknown nuisance parameters. Additionally, to improve the accuracy of the estimation procedure, we formulate and solve an optimization problem by minimizing the CRB on the angular-velocity estimate with respect to the transmitting OFDM spectral coefficients. We present several numerical examples to demonstrate the CRB variations at different values of the signal-to-noise ratio (SNR) and the number of OFDM subcarriers. The CRB values not only decrease with the increase in the SNR values, but also reduce as we increase the number of subcarriers implying the significance of frequency-diverse OFDM waveforms. The improvement in estimation accuracy due to the adaptive waveform design is also numerically analyzed. Interestingly, we find that the relative decrease in the CRBs on the angular-velocity estimate is more pronounced for larger number of OFDM subcarriers.

  3. Performance bounds on micro-Doppler estimation and adaptive waveform design using OFDM signals

    Science.gov (United States)

    Sen, Satyabrata; Barhen, Jacob; Glover, Charles W.

    2014-05-01

    We analyze the performance of a wideband orthogonal frequency division multiplexing (OFDM) signal in estimating the micro-Doppler frequency of a target having multiple rotating scatterers (e.g., rotor blades of a helicopter, propellers of a submarine). The presence of rotating scatterers introduces Doppler frequency modulation in the received signal by generating sidebands about the transmitted frequencies. This is called the micro-Doppler effects. The use of a frequency-diverse OFDM signal in this context enables us to independently analyze the micro-Doppler characteristics with respect to a set of orthogonal subcarrier frequencies. Therefore, to characterize the accuracy of micro-Doppler frequency estimation, we compute the Craḿer-Rao Bound (CRB) on the angular-velocity estimate of the target while considering the scatterer responses as deterministic but unknown nuisance parameters. Additionally, to improve the accuracy of the estimation procedure, we formulate and solve an optimization problem by minimizing the CRB on the angular-velocity estimate with respect to the transmitting OFDM spectral coefficients. We present several numerical examples to demonstrate the CRB variations at different values of the signal-to-noise ratio (SNR) and the number of OFDM subcarriers. The CRB values not only decrease with the increase in the SNR values, but also reduce as we increase the number of subcarriers implying the significance of frequency-diverse OFDM waveforms. The improvement in estimation accuracy due to the adaptive waveform design is also numerically analyzed. Interestingly, we find that the relative decrease in the CRBs on the angular-velocity estimate is more pronounced for larger number of OFDM subcarriers.

  4. Design Implementation and Testing of a VLSI High Performance ASIC for Extracting the Phase of a Complex Signal

    National Research Council Canada - National Science Library

    Altmeyer, Ronald

    2002-01-01

    This thesis documents the research, circuit design, and simulation testing of a VLSI ASIC which extracts phase angle information from a complex sampled signal using the arctangent relationship: (phi=tan/-1 (Q/1...

  5. A theoretical signal processing framework for linear diffusion MRI: Implications for parameter estimation and experiment design.

    Science.gov (United States)

    Varadarajan, Divya; Haldar, Justin P

    2017-11-01

    The data measured in diffusion MRI can be modeled as the Fourier transform of the Ensemble Average Propagator (EAP), a probability distribution that summarizes the molecular diffusion behavior of the spins within each voxel. This Fourier relationship is potentially advantageous because of the extensive theory that has been developed to characterize the sampling requirements, accuracy, and stability of linear Fourier reconstruction methods. However, existing diffusion MRI data sampling and signal estimation methods have largely been developed and tuned without the benefit of such theory, instead relying on approximations, intuition, and extensive empirical evaluation. This paper aims to address this discrepancy by introducing a novel theoretical signal processing framework for diffusion MRI. The new framework can be used to characterize arbitrary linear diffusion estimation methods with arbitrary q-space sampling, and can be used to theoretically evaluate and compare the accuracy, resolution, and noise-resilience of different data acquisition and parameter estimation techniques. The framework is based on the EAP, and makes very limited modeling assumptions. As a result, the approach can even provide new insight into the behavior of model-based linear diffusion estimation methods in contexts where the modeling assumptions are inaccurate. The practical usefulness of the proposed framework is illustrated using both simulated and real diffusion MRI data in applications such as choosing between different parameter estimation methods and choosing between different q-space sampling schemes. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Design of complete software GPS signal simulator with low complexity and precise multipath channel model

    Directory of Open Access Journals (Sweden)

    G. Arul Elango

    2016-09-01

    Full Text Available The need for GPS data simulators have become important due to the tremendous growth in the design of versatile GPS receivers. Commercial hardware and software based GPS simulators are expensive and time consuming. In this work, a low cost simple novel GPS L1 signal simulator is designed for testing and evaluating the performance of software GPS receiver in a laboratory environment. A typical real time paradigm, similar to actual satellite derived GPS signal is created on a computer generated scenario. In this paper, a GPS software simulator is proposed that may offer a lot of analysis and testing flexibility to the researchers and developers as it is totally software based primarily running on a laptop/personal computer without the requirement of any hardware. The proposed GPS simulator allows provision for re-configurability and test repeatability and is developed in VC++ platform to minimize the simulation time. It also incorporates Rayleigh multipath channel fading model under non-line of sight (NLOS conditions. In this work, to efficiently design the simulator, several Rayleigh fading models viz. Inverse Discrete Fourier Transform (IDFT, Filtering White Gaussian Noise (FWFN and modified Sum of Sinusoidal (SOS simulators are tested and compared in terms of accuracy of its first and second order statistical metrics, execution time and the later one is found to be as the best appropriate Rayleigh multipath model suitable for incorporating with GPS simulator. The fading model written in ‘MATLAB’ engine has been linked with software GPS simulator module enable to test GPS receiver’s functionality in different fading environments.

  7. Tests of variable-band multilayers designed for investigating optimal signal-to-noise vs artifact signal ratios in Dual-Energy Digital Subtraction Angiography (DDSA) imaging systems

    International Nuclear Information System (INIS)

    Boyers, D.; Ho, A.; Li, Q.; Piestrup, M.; Rice, M.; Tatchyn, R.

    1993-08-01

    In recent work, various design techniques were applied to investigate the feasibility of controlling the bandwidth and bandshape profiles of tungsten/boron-carbon (W/B 4 C) and tungsten/silicon (W/Si) multilayers for optimizing their performance in synchrotron radiation based angiographical imaging systems at 33 keV. Varied parameters included alternative spacing geometries, material thickness ratios, and numbers of layer pairs. Planar optics with nominal design reflectivities of 30%--94% and bandwidths ranging from 0.6%--10% were designed at the Stanford Radiation Laboratory, fabricated by the Ovonic Synthetic Materials Company, and characterized on Beam Line 4-3 at the Stanford Synchrotron Radiation Laboratory, in this paper we report selected results of these tests and review the possible use of the multilayers for determining optimal signal to noise vs. artifact signal ratios in practical Dual-Energy Digital Subtraction Angiography systems

  8. Hyperpolarized 13C MRS surface coil: design and signal-to-noise ratio estimation.

    Science.gov (United States)

    Giovannetti, Giulio; Frijia, Francesca; Menichetti, Luca; Milanesi, Matteo; Ardenkjaer-Larsen, Jan Henrik; De Marchi, Daniele; Hartwig, Valentina; Positano, Vincenzo; Landini, Luigi; Lombardi, Massimo; Santarelli, Maria Filomena

    2010-10-01

    Hyperpolarized carbon-13 magnetic resonance spectroscopy is a novel and powerful tool for exploring the metabolic state of tissue, but a number of technological problems still limit this technology and need innovative solutions. In particular, the low molar concentration of derivate metabolites give rise to low signal-to-noise ratio (SNR), which makes the design and development of dedicated RF coils a task of fundamental importance. In this article, the authors describe the simulation and the design of a dedicated 13C surface coil for cardiac metabolism assessment in pig models. A SNR model for a circular loop is presented and applied to the design of a 13C coil which guarantees the desired field-of-view and provides high SNR with a good penetration in deep sample regions. The coil resistance was calculated from Ohm's law and the magnetic field pattern was calculated using Biot-Savart law, while the sample induced resistance was calculated using a numerical finite-difference time-domain algorithm. Successively, a prototype of the coil was built and tested on the workbench and by acquisition of MR data. The comparison of SNR-vs-depth profiles between the theoretical SNR model and the experimental SNR extracted from the phantom chemical shift image (CSI) showed the accuracy of the authors' model. Moreover, the authors demonstrated the use of the coil for the acquisition of a CSI of a hyperpolarized [1-13C] pyruvate phantom. The results demonstrated the design trade-offs to successfully design a dedicated coil for cardiac imaging in the pig with hyperpolarized 13C by developing a SNR model which allows the prediction of the coil performance. This approach can be employed for deriving SNR formulations for coil with more complex geometries.

  9. Design and prototyping of a wristband-type wireless photoplethysmographic device for heart rate variability signal analysis.

    Science.gov (United States)

    Ghamari, M; Soltanpur, C; Cabrera, S; Romero, R; Martinek, R; Nazeran, H

    2016-08-01

    Heart Rate Variability (HRV) signal analysis provides a quantitative marker of the Autonomic Nervous System (ANS) function. A wristband-type wireless photoplethysmographic (PPG) device was custom-designed to collect and analyze the arterial pulse in the wrist. The proposed device is comprised of an optical sensor to monitor arterial pulse, a signal conditioning unit to filter and amplify the analog PPG signal, a microcontroller to digitize the analog PPG signal, and a Bluetooth module to transfer the data to a smart device. This paper proposes a novel model to represent the PPG signal as the summation of two Gaussian functions. The paper concludes with a verification procedure for HRV signal analysis during sedentary activities.

  10. An optimized cosine-modulated nonuniform filter bank design for subband coding of ECG signal

    Directory of Open Access Journals (Sweden)

    A. Kumar

    2015-07-01

    Full Text Available A simple iterative technique for the design of nonuniform cosine modulated filter banks (CMFBS is presented in this paper. The proposed technique employs a single parameter for optimization. The nonuniform cosine modulated filter banks are derived by merging the adjacent filters of uniform cosine modulated filter banks. The prototype filter is designed with the aid of different adjustable window functions such as Kaiser, Cosh and Exponential, and by using the constrained equiripple finite impulse response (FIR digital filter design technique. In this method, either cut off frequency or passband edge frequency is varied in order to adjust the filter coefficients so that reconstruction error could be optimized/minimized to zero. Performance and effectiveness of the proposed method in terms of peak reconstruction error (PRE, aliasing distortion (AD, computational (CPU time, and number of iteration (NOI have been shown through the numerical examples and comparative studies. Finally, the technique is exploited for the subband coding of electrocardiogram (ECG and speech signals.

  11. Design of the incentive mechanism in electricity auction market based on the signaling game theory

    International Nuclear Information System (INIS)

    Liu, Zhen; Zhang, Xiliang; Lieu, Jenny

    2010-01-01

    At present, designing a proper bidding mechanism to decrease the generators' market power is considered to be one of the key approaches to deepen the reform of the electricity market. Based on the signaling game theory, the paper analyzes the main electricity bidding mechanisms in the electricity auction markets and considers the degree of information disturbance as an important factor for evaluating bidding mechanisms. Under the above studies, an incentive electricity bidding mechanism defined as the Generator Semi-randomized Matching (GSM) mechanism is proposed. In order to verify the new bidding mechanism, this paper uses the Swarm platform to develop a simulation model based on the multi-agents. In the simulation model, the generators and purchasers use the partly superior study strategy to adjust their price and their electricity quantity. Then, the paper examines a simulation experiment of the GSM bidding mechanism and compares it to a simulation of the High-Low Matching (HLM) bidding mechanism. According to the simulation results, several conclusions can be drawn when comparing the proposed GSM bidding mechanism to the equilibrium state of HLM: the clearing price decreases, the total transaction volume increases, the profits of electricity generators decreases, and the overall benefits of purchasers increases. Index Terms - signaling game; semi-randomized matching; high-low match. (author)

  12. Optimal Design of Signal Controlled Road Networks Using Differential Evolution Optimization Algorithm

    Directory of Open Access Journals (Sweden)

    Huseyin Ceylan

    2013-01-01

    Full Text Available This study proposes a traffic congestion minimization model in which the traffic signal setting optimization is performed through a combined simulation-optimization model. In this model, the TRANSYT traffic simulation software is combined with Differential Evolution (DE optimization algorithm, which is based on the natural selection paradigm. In this context, the EQuilibrium Network Design (EQND problem is formulated as a bilevel programming problem in which the upper level is the minimization of the total network performance index. In the lower level, the traffic assignment problem, which represents the route choice behavior of the road users, is solved using the Path Flow Estimator (PFE as a stochastic user equilibrium assessment. The solution of the bilevel EQND problem is carried out by the proposed Differential Evolution and TRANSYT with PFE, the so-called DETRANSPFE model, on a well-known signal controlled test network. Performance of the proposed model is compared to that of two previous works where the EQND problem has been solved by Genetic-Algorithms- (GAs- and Harmony-Search- (HS- based models. Results show that the DETRANSPFE model outperforms the GA- and HS-based models in terms of the network performance index and the computational time required.

  13. Optimal synaptic signaling connectome for locomotory behavior in Caenorhabditis elegans: Design minimizing energy cost.

    Directory of Open Access Journals (Sweden)

    Franciszek Rakowski

    2017-11-01

    Full Text Available The detailed knowledge of C. elegans connectome for 3 decades has not contributed dramatically to our understanding of worm's behavior. One of main reasons for this situation has been the lack of data on the type of synaptic signaling between particular neurons in the worm's connectome. The aim of this study was to determine synaptic polarities for each connection in a small pre-motor circuit controlling locomotion. Even in this compact network of just 7 neurons the space of all possible patterns of connection types (excitation vs. inhibition is huge. To deal effectively with this combinatorial problem we devised a novel and relatively fast technique based on genetic algorithms and large-scale parallel computations, which we combined with detailed neurophysiological modeling of interneuron dynamics and compared the theory to the available behavioral data. As a result of these massive computations, we found that the optimal connectivity pattern that matches the best locomotory data is the one in which all interneuron connections are inhibitory, even those terminating on motor neurons. This finding is consistent with recent experimental data on cholinergic signaling in C. elegans, and it suggests that the system controlling locomotion is designed to save metabolic energy. Moreover, this result provides a solid basis for a more realistic modeling of neural control in these worms, and our novel powerful computational technique can in principle be applied (possibly with some modifications to other small-scale functional circuits in C. elegans.

  14. A multi-frequency EIT system design based on telecommunication signal processors.

    Science.gov (United States)

    Robitaille, Nicolas; Guardo, Robert; Maurice, Isabelle; Hartinger, Alzbeta E; Gagnon, Hervé

    2009-06-01

    A multi-frequency electrical impedance tomography system for cardiopulmonary monitoring has been designed with specialized digital signal processors developed primarily for the telecommunications sector. The system consists of two modules: a scan-head and a base-station. The scan-head, located close to the patient's torso, contains front-end circuits for measuring transfer impedance with a 16-electrode array. The base-station, placed at the bedside, comprises 16 direct digital synthesizers, 32 digital down-converters, digital circuits to control the data acquisition sequence and a USB-2.0 microcontroller. At every step of the scan sequence, the system simultaneously measures four complex variables at eight frequencies. These variables are the potential difference between the selected pair of sense electrodes, the currents applied by the source and sink electrodes, and the current flowing through the ground electrode. Frequencies are programmable from 10 kHz to 2 MHz with a resolution of 2 mHz. Characterization tests were performed with a precision mesh phantom connected to the scan-head. For a 5 Hz frame rate, the mean signal-to-noise ratio and accuracy are, respectively, 43 dB and 95.4% for eight frequencies logarithmically spaced from 70 to 950 kHz. In vitro and in vivo time-difference images have been reconstructed.

  15. Optimal filter design to compute the mean of cardiovascular pressure signals.

    Science.gov (United States)

    Ellis, Timothy; McNames, James; Goldstein, Brahm

    2008-04-01

    The mean pressure is a term used to describe the baseline trend of physiological pressure signals that excludes fluctuations due to the cardiac cycle and, in some cases, the respiratory cycle. In many clinical applications and bedside monitoring devices, the mean pressure is estimated with a 3-8 s moving average. We suggest that the mean pressure is best defined in terms of its frequency domain properties. This definition makes it possible to determine solutions that are both optimal and practical. We demonstrate that established methods of optimal finite impulse response (FIR) filter design produce estimates of the mean pressure that are significantly more accurate than the moving average. These filters have no more computational cost, are less sensitive to artifact, have shorter delays, and greater sensitivity to acute events.

  16. Five Years of Designing Wireless Sensor Networks in the Doñana Biological Reserve (Spain): An Applications Approach

    Science.gov (United States)

    Larios, Diego F.; Barbancho, Julio; Sevillano, José L.; Rodríguez, Gustavo; Molina, Francisco J.; Gasull, Virginia G.; Mora-Merchan, Javier M.; León, Carlos

    2013-01-01

    Wireless Sensor Networks (WSNs) are a technology that is becoming very popular for many applications, and environmental monitoring is one of its most important application areas. This technology solves the lack of flexibility of wired sensor installations and, at the same time, reduces the deployment costs. To demonstrate the advantages of WSN technology, for the last five years we have been deploying some prototypes in the Doñana Biological Reserve, which is an important protected area in Southern Spain. These prototypes not only evaluate the technology, but also solve some of the monitoring problems that have been raised by biologists working in Doñana. This paper presents a review of the work that has been developed during these five years. Here, we demonstrate the enormous potential of using machine learning in wireless sensor networks for environmental and animal monitoring because this approach increases the amount of useful information and reduces the effort that is required by biologists in an environmental monitoring task. PMID:24025554

  17. Design, parametrization, and pole placement of stabilizing output feedback compensators via injective cogenerator quotient signal modules.

    Science.gov (United States)

    Blumthaler, Ingrid; Oberst, Ulrich

    2012-03-01

    Control design belongs to the most important and difficult tasks of control engineering and has therefore been treated by many prominent researchers and in many textbooks, the systems being generally described by their transfer matrices or by Rosenbrock equations and more recently also as behaviors. Our approach to controller design uses, in addition to the ideas of our predecessors on coprime factorizations of transfer matrices and on the parametrization of stabilizing compensators, a new mathematical technique which enables simpler design and also new theorems in spite of the many outstanding results of the literature: (1) We use an injective cogenerator signal module ℱ over the polynomial algebra [Formula: see text] (F an infinite field), a saturated multiplicatively closed set T of stable polynomials and its quotient ring [Formula: see text] of stable rational functions. This enables the simultaneous treatment of continuous and discrete systems and of all notions of stability, called T-stability. We investigate stabilizing control design by output feedback of input/output (IO) behaviors and study the full feedback IO behavior, especially its autonomous part and not only its transfer matrix. (2) The new technique is characterized by the permanent application of the injective cogenerator quotient signal module [Formula: see text] and of quotient behaviors [Formula: see text] of [Formula: see text]-behaviors B. (3) For the control tasks of tracking, disturbance rejection, model matching, and decoupling and not necessarily proper plants we derive necessary and sufficient conditions for the existence of proper stabilizing compensators with proper and stable closed loop behaviors, parametrize all such compensators as IO behaviors and not only their transfer matrices and give new algorithms for their construction. Moreover we solve the problem of pole placement or spectral assignability for the complete feedback behavior. The properness of the full feedback behavior

  18. Input/output Buffer based Vedic Multiplier Design for Thermal Aware Energy Efficient Digital Signal Processing on 28nm FPGA

    DEFF Research Database (Denmark)

    Goswami, Kavita; Pandey, Bishwajeet; Hussain, Dil muhammed Akbar

    2016-01-01

    Programmable Gate Array (FPGA) in order to reduce the development cost. The development cost for Application Specific Integrated Circuits (ASICs) are high in compare to FPGA. Selection of the most energy efficient IO standards in place of signal gating is the main design methodology for design of energy...

  19. Designing GABA-edited magnetic resonance spectroscopy studies: Considerations of scan duration, signal-to-noise ratio and sample size.

    Science.gov (United States)

    Mikkelsen, Mark; Loo, Rachelle S; Puts, Nicolaas A J; Edden, Richard A E; Harris, Ashley D

    2018-02-21

    The relationships between scan duration, signal-to-noise ratio (SNR) and sample size must be considered and understood to design optimal GABA-edited magnetic resonance spectroscopy (MRS) studies. Simulations investigated the effects of signal averaging on SNR, measurement error and group-level variance against a known ground truth. Relative root mean square errors (measurement error) and coefficients of variation (group-level variance) were calculated. GABA-edited data from 18 participants acquired from five voxels were used to examine the relationships between scan duration, SNR and quantitative outcomes in vivo. These relationships were then used to determine the sample sizes required to observe different effect sizes. In both simulated and in vivo data, SNR increased with the square root of the number of averages. Both measurement error and group-level variance were shown to follow an inverse-square-root function, indicating no significant impact of cumulative artifacts. Comparisons between the first two-thirds of the data and the full dataset showed no statistical difference in group-level variance. There was, however, some variability across the five voxels depending on SNR, which impacted the sample sizes needed to detect group differences in specific brain regions. Typical scan durations can be reduced if taking into account a statistically acceptable amount of variance and the magnitudes of predicted effects. While scan duration in GABA-edited MRS has typically been considered in terms of SNR, it is more appropriate to think in terms of the amount of measurement error and group-level variance that provides sufficient statistical power. Copyright © 2018 Elsevier B.V. All rights reserved.

  20. Oilbirds produce echolocation signals beyond their best hearing range and adjust signal design to natural light conditions.

    Science.gov (United States)

    Brinkløv, Signe; Elemans, Coen P H; Ratcliffe, John M

    2017-05-01

    Oilbirds are active at night, foraging for fruits using keen olfaction and extremely light-sensitive eyes, and echolocate as they leave and return to their cavernous roosts. We recorded the echolocation behaviour of wild oilbirds using a multi-microphone array as they entered and exited their roosts under different natural light conditions. During echolocation, the birds produced click bursts (CBs) lasting less than 10 ms and consisting of a variable number (2-8) of clicks at 2-3 ms intervals. The CBs have a bandwidth of 7-23 kHz at -6 dB from signal peak frequency. We report on two unique characteristics of this avian echolocation system. First, oilbirds reduce both the energy and number of clicks in their CBs under conditions of clear, moonlit skies, compared with dark, moonless nights. Second, we document a frequency mismatch between the reported best frequency of oilbird hearing (approx. 2 kHz) and the bandwidth of their echolocation CBs. This unusual signal-to-sensory system mismatch probably reflects avian constraints on high-frequency hearing but may still allow oilbirds fine-scale, close-range detail resolution at the upper extreme (approx. 10 kHz) of their presumed hearing range. Alternatively, oilbirds, by an as-yet unknown mechanism, are able to hear frequencies higher than currently appreciated.

  1. Oilbirds produce echolocation signals beyond their best hearing range and adjust signal design to natural light conditions

    Science.gov (United States)

    Brinkløv, Signe; Elemans, Coen P. H.

    2017-01-01

    Oilbirds are active at night, foraging for fruits using keen olfaction and extremely light-sensitive eyes, and echolocate as they leave and return to their cavernous roosts. We recorded the echolocation behaviour of wild oilbirds using a multi-microphone array as they entered and exited their roosts under different natural light conditions. During echolocation, the birds produced click bursts (CBs) lasting less than 10 ms and consisting of a variable number (2–8) of clicks at 2–3 ms intervals. The CBs have a bandwidth of 7–23 kHz at −6 dB from signal peak frequency. We report on two unique characteristics of this avian echolocation system. First, oilbirds reduce both the energy and number of clicks in their CBs under conditions of clear, moonlit skies, compared with dark, moonless nights. Second, we document a frequency mismatch between the reported best frequency of oilbird hearing (approx. 2 kHz) and the bandwidth of their echolocation CBs. This unusual signal-to-sensory system mismatch probably reflects avian constraints on high-frequency hearing but may still allow oilbirds fine-scale, close-range detail resolution at the upper extreme (approx. 10 kHz) of their presumed hearing range. Alternatively, oilbirds, by an as-yet unknown mechanism, are able to hear frequencies higher than currently appreciated. PMID:28573036

  2. Manipulating and detecting the chirpiness of spatial chirp signals via fractional Fourier lenses designed by transformation optics.

    Science.gov (United States)

    Chen, Jing; Hu, Jin; Yang, Xiao-Bo; Lu, Xiang-Yang

    2017-11-10

    Estimating the chirpiness of a spatial chirp signal is important in many optical engineering applications. With the help of transformation optics, a new kind of fractional Fourier transform lens is designed by deforming the conventional graded index lens through conformal mapping, which can manipulate the chirpiness of the input chirp signal. The low-input chirpiness is magnified by the transformation material, and the error of the detection is kept approximately the same; thus, the designed lens has enhanced chirpiness detection precision and distinguishability for low chirpiness. The design is validated by numerical simulations.

  3. Signal detection circuit design of HCN measurement system based on TDLAS

    Science.gov (United States)

    He, Chungui; Zhang, Yujun; Chen, Chen; Lu, Yibing; Liu, Guohua; Gao, Yanwei; You, Kun; He, Ying; Zhang, Kai; Liu, Wenqing

    2016-10-01

    Hydrogen cyanide gas leakage may exist in the petrochemical industry, smelting plant, and other industrial processes, causing serious harm to the environment, and even threatening the safety of personnel. So the continuous detection of HCN gas plays an important role in the prevention of risk in production process and storage environment that existing hydrogen cyanide gas. The Tunable Diode Laser Technology (TDLAS) has advantages of non-contact, high sensitivity, high selectivity, and fast response time, etc., which is one of the ideal method of gas detection technologies and can be used to measure the hydrogen cyanide concentration. This paper studies the HCN detection system based on TDLAS technology, selects the absorption lines of hydrogen cyanide in 6539.12cm-1, and utilizes the center wavelength of 1.529μm distributed feedback (DFB) laser as a light source. It is discussed in detail on technical requirements of a high frequency modulated laser signal detection circuit, including noise level, gain, and bandwidth. Based on the above theory, the high frequency modulation preamplifier circuit and main amplifier circuit are designed for InGaAs photoelectric detector. The designed circuits are calculation analyzed with corresponding formula and simulation analyzed based on the Multisim software.

  4. Design and implementation of a data acquisition system for the study of dynamics signals in the time Domain

    Energy Technology Data Exchange (ETDEWEB)

    Daza, Arnoldo; Hinojosa, Ana; Diaz, Xavier; Neira, Oscar, E-mail: gelunicesar@gmail.com [Laser Spectroscopy Group, Room 204 Block I, Universidad Popular del Cesar, Valledupar - Cesar (Colombia)

    2011-01-01

    The purpose of this research was to design and implement a data acquisition system for the study of dynamic signals in the time in order of nanoseconds, through the use of electronic instrumentation to obtain the temporal profiles of light signals, such as pulses of light from a laser or fluorescent light signals. To carry out the design and implementation of the data acquisition system proposed, we used a rapid response transducer and a data acquisition card of high speed. As well, it was developed a graphical user interface for visualization, analysis and study of the data acquired. Thus, it was possible to perform the digitization of a pulse on the order of nanoseconds, as well as the acquisition of fluorescence signals of different wavelengths, from which to obtain theoretical and experimental valuable knowledge based on the physics of spectroscopy.

  5. Design and measurements of 64-channel ASIC for neural signal recording.

    Science.gov (United States)

    Kmon, P; Zoladz, M; Grybos, P; Szczygiel, R

    2009-01-01

    This paper presents the design and measurements of a low noise multi-channel front-end electronics for recording extra-cellular neuronal signals using microelectrode arrays. The integrated circuit contains 64 readout channels and was fabricated in CMOS 0.18 microm technology. A single readout channel is built of an AC coupling circuit at the input, a low noise preamplifier, a band-pass filter and a second amplifier. In order to reduce the number of output lines, the 64 analog signals from readout channels are multiplexed to a single output by an analog multiplexer. The chip is optimized for low noise and matching performance with the possibility of cut-off frequencies tuning. The low cut-off frequency can be tuned in the 1 Hz-60 Hz range and the high cut-off frequency can be tuned in the 3.5 kHz-15 kHz range. For the nominal gain setting at 44 dB and power dissipation per single channel of 220 microW the equivalent input noise is in the range from 6 microV-11 microV rms depending on the band-pass filter settings. The chip has good uniformity concerning the spread of its electrical parameters from channel to channel. The spread of gain calculated as standard deviation to mean value is about 4.4% and the spread of the low cut-off frequency is on the same level. The chip occupies 5x2.3 mm(2) of silicon area.

  6. Design of excitation signals for active system monitoring in a performance assessment setup

    DEFF Research Database (Denmark)

    Green, Torben; Izadi-Zamanabadi, Roozbeh; Niemann, Hans Henrik

    2011-01-01

    This paper investigates how the excitation signal should be chosen for a active performance setup. The signal is used in a setup where the main purpose is to detect whether a parameter change of the controller has changed the global performance significantly. The signal has to be able to excite t...

  7. Design for a New Signal Analyzer through a Circuit Modeling Simulation as a One Body System for SAC's

    International Nuclear Information System (INIS)

    Kil-Mo, Koo; Sang-Baik, Kim; Hee-Dong, Kim; Hae-Yong, Kang

    2006-01-01

    A circuit simulation analysis and diagnosis methods are used to diagnose instruments in detail when they give apparently abnormal readings. In this paper, a new simulator for analyzing the modeling of important circuits under SACs(severe accident conditions) has been designed. The realization of a one body system by using a one order command system in the LabVIEW and Pspice was used instead of a complex two body system. The program shows the output data from the circuit modeling according to a one order command system. The procedure for the simulator design was divided into two steps, of which the first step was the design of the diagnosis methods, and the second step was a circuit simulator for the signal processing tool and the special signal analysis tool. It has three main functions which are a signal processing tool, an accident management tool, and an additional guide from the initial screen. (authors)

  8. Designing driver assistance systems with crossmodal signals: multisensory integration rules for saccadic reaction times apply.

    Directory of Open Access Journals (Sweden)

    Rike Steenken

    Full Text Available Modern driver assistance systems make increasing use of auditory and tactile signals in order to reduce the driver's visual information load. This entails potential crossmodal interaction effects that need to be taken into account in designing an optimal system. Here we show that saccadic reaction times to visual targets (cockpit or outside mirror, presented in a driving simulator environment and accompanied by auditory or tactile accessories, follow some well-known spatiotemporal rules of multisensory integration, usually found under confined laboratory conditions. Auditory nontargets speed up reaction time by about 80 ms. The effect tends to be maximal when the nontarget is presented 50 ms before the target and when target and nontarget are spatially coincident. The effect of a tactile nontarget (vibrating steering wheel was less pronounced and not spatially specific. It is shown that the average reaction times are well-described by the stochastic "time window of integration" model for multisensory integration developed by the authors. This two-stage model postulates that crossmodal interaction occurs only if the peripheral processes from the different sensory modalities terminate within a fixed temporal interval, and that the amount of crossmodal interaction manifests itself in an increase or decrease of second stage processing time. A qualitative test is consistent with the model prediction that the probability of interaction, but not the amount of crossmodal interaction, depends on target-nontarget onset asynchrony. A quantitative model fit yields estimates of individual participants' parameters, including the size of the time window. Some consequences for the design of driver assistance systems are discussed.

  9. Design of eddy current probes and signal inversion for non-destructive testing

    International Nuclear Information System (INIS)

    Ravat, C.

    2008-01-01

    Non destructive testing is widely used in aerospace industry and nuclear industry. The growing complexity of industrial processes and manufactured parts, the increasing need of safety in service and the will of life span optimization, require more and more complex quality evaluations to be set up. Among the different anomalies to consider, sub-millimetric breaking surface notches have to be subject to special care. Indeed, it often constitutes a start to larger notches, which can cause the destruction of parts. Penetrant testing is nowadays widely used for that kind of defect, owing to its good performances. Nevertheless, it should be eventually dropped because of environmental norms. Among the possible substitution solutions, the use of eddy currents (EC) for conductive parts is a reliable, fast and inexpensive alternative. The study is about the conception and the use of multi-elements EC probe structures featuring microsensors for non destructive testing of surface breaking defects. A methodology has been established in order to develop such structures and to compare their performances within the framework of sub-millimetric surface breaking notch research. These structures has been employed for calibrated notches evaluation with a specific acquisition bench. Original detection and defect characterization algorithms have been designed and implemented on acquired signals. The most efficient structure has been determined, the notch detection quality has been quantified, and the geometric characteristics of notches has been estimated. (author)

  10. Simultaneous design of FIR filter banks and spatial patterns for EEG signal classification.

    Science.gov (United States)

    Higashi, Hiroshi; Tanaka, Toshihisa

    2013-04-01

    The spatial weights for electrodes called common spatial pattern (CSP) are known to be effective in EEG signal classification for motor imagery-based brain-computer interface (MI-BCI). To achieve accurate classification in CSP, it is necessary to find frequency bands that relate to brain activities associated with BCI tasks. Several methods that determine such a set of frequency bands have been proposed. However, the existing methods cannot find the multiple frequency bands by using only learning data. To address this problem, we propose discriminative filter bank CSP (DFBCSP) that designs finite impulse response filters and the associated spatial weights by optimizing an objective function which is a natural extension of that of CSP. The optimization is conducted by sequentially and alternatively solving subproblems into which the original problem is divided. By experiments, it is shown that DFBCSP can effectively extract discriminative features for MI-BCI. Moreover, experimental results exhibit that DFBCSP can detect and extract the bands related to brain activities of motor imagery.

  11. An Intelligent Vehicular Traffic Signal Control System with State Flow Chart Design and FPGA Prototyping

    Directory of Open Access Journals (Sweden)

    UMAIR SAEEDSOLANGI

    2017-04-01

    Full Text Available The problem of vehicular traffic congestion is a persistent constraint in the socio-economic development of Pakistan. This paper presents design and implementation of an intelligent traffic controller based on FPGA (Field Programmable Gate Array to provide an efficient traffic management by optimizing functioning of traffic lights which will result in minimizing traffic congestion at intersections. The existent Traffic Signal system in Pakistan is fixed-time based and offers only Open Loop method for Traffic Control. The Intelligent Traffic Controller presented here uses feedback sensors to read the Traffic density present at a four way intersection to provide an efficient alternative for better supervisory Control of Traffic flow. The traffic density based control logic has been developed in a State Flow Chart for improved visualization of State Machine based operation, and implemented as a Subsystem in Simulink and transferred into VHDL (Hardware Description Language code using HDL Coder for reducing development time and time to market, which are essential to capitalize Embedded Systems Market. The VHDL code is synthesized with Altera QUARTUS, simulated timing waveform is obtained to verify correctness of the algorithm for different Traffic Scenarios. For implementation purpose estimations were obtained for Cyclone-III and Stratix-III.

  12. An intelligent vehicular traffic signal control system with state flow chart design and fpga prototyping

    International Nuclear Information System (INIS)

    Solangi, U.S.; Memon, T.D.; Noonari, A.S.; Ansari, O.A.

    2017-01-01

    The problem of vehicular traffic congestion is a persistent constraint in the socio-economic development of Pakistan. This paper presents design and implementation of an intelligent traffic controller based on FPGA (Field Programmable Gate Array) to provide an efficient traffic management by optimizing functioning of traffic lights which will result in minimizing traffic congestion at intersections. The existent Traffic Signal system in Pakistan is fixed-time based and offers only Open Loop method for Traffic Control. The Intelligent Traffic Controller presented here uses feedback sensors to read the Traffic density present at a four way intersection to provide an efficient alternative for better supervisory Control of Traffic flow. The traffic density based control logic has been developed in a State Flow Chart for improved visualization of State Machine based operation, and implemented as a Subsystem in Simulink and transferred into VHDL (Hardware Description Language) code using HDL Coder for reducing development time and time to market, which are essential to capitalize Embedded Systems Market. The VHDL code is synthesized with Altera QUARTUS, simulated timing waveform is obtained to verify correctness of the algorithm for different Traffic Scenarios. For implementation purpose estimations were obtained for Cyclone-III and Stratix-III. (author)

  13. Extreme temperature robust optical sensor designs and fault-tolerant signal processing

    Science.gov (United States)

    Riza, Nabeel Agha [Oviedo, FL; Perez, Frank [Tujunga, CA

    2012-01-17

    Silicon Carbide (SiC) probe designs for extreme temperature and pressure sensing uses a single crystal SiC optical chip encased in a sintered SiC material probe. The SiC chip may be protected for high temperature only use or exposed for both temperature and pressure sensing. Hybrid signal processing techniques allow fault-tolerant extreme temperature sensing. Wavelength peak-to-peak (or null-to-null) collective spectrum spread measurement to detect wavelength peak/null shift measurement forms a coarse-fine temperature measurement using broadband spectrum monitoring. The SiC probe frontend acts as a stable emissivity Black-body radiator and monitoring the shift in radiation spectrum enables a pyrometer. This application combines all-SiC pyrometry with thick SiC etalon laser interferometry within a free-spectral range to form a coarse-fine temperature measurement sensor. RF notch filtering techniques improve the sensitivity of the temperature measurement where fine spectral shift or spectrum measurements are needed to deduce temperature.

  14. Design of a completely model free adaptive control in the presence of parametric, non-parametric uncertainties and random control signal delay.

    Science.gov (United States)

    Tutsoy, Onder; Barkana, Duygun Erol; Tugal, Harun

    2018-03-14

    In this paper, an adaptive controller is developed for discrete time linear systems that takes into account parametric uncertainty, internal-external non-parametric random uncertainties, and time varying control signal delay. Additionally, the proposed adaptive control is designed in such a way that it is utterly model free. Even though these properties are studied separately in the literature, they are not taken into account all together in adaptive control literature. The Q-function is used to estimate long-term performance of the proposed adaptive controller. Control policy is generated based on the long-term predicted value, and this policy searches an optimal stabilizing control signal for uncertain and unstable systems. The derived control law does not require an initial stabilizing control assumption as in the ones in the recent literature. Learning error, control signal convergence, minimized Q-function, and instantaneous reward are analyzed to demonstrate the stability and effectiveness of the proposed adaptive controller in a simulation environment. Finally, key insights on parameters convergence of the learning and control signals are provided. Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.

  15. Evolution and Design Governing Signal Precision and Amplification in a Bacterial Chemosensory Pathway.

    Directory of Open Access Journals (Sweden)

    Mathilde Guzzo

    2015-08-01

    Full Text Available Understanding the principles underlying the plasticity of signal transduction networks is fundamental to decipher the functioning of living cells. In Myxococcus xanthus, a particular chemosensory system (Frz coordinates the activity of two separate motility systems (the A- and S-motility systems, promoting multicellular development. This unusual structure asks how signal is transduced in a branched signal transduction pathway. Using combined evolution-guided and single cell approaches, we successfully uncoupled the regulations and showed that the A-motility regulation system branched-off an existing signaling system that initially only controlled S-motility. Pathway branching emerged in part following a gene duplication event and changes in the circuit structure increasing the signaling efficiency. In the evolved pathway, the Frz histidine kinase generates a steep biphasic response to increasing external stimulations, which is essential for signal partitioning to the motility systems. We further show that this behavior results from the action of two accessory response regulator proteins that act independently to filter and amplify signals from the upstream kinase. Thus, signal amplification loops may underlie the emergence of new connectivity in signal transduction pathways.

  16. Design of Flow Systems for Improved Networking and Reduced Noise in Biomolecular Signal Processing in Biocomputing and Biosensing Applications

    Directory of Open Access Journals (Sweden)

    Arjun Verma

    2016-07-01

    Full Text Available We consider flow systems that have been utilized for small-scale biomolecular computing and digital signal processing in binary-operating biosensors. Signal measurement is optimized by designing a flow-reversal cuvette and analyzing the experimental data to theoretically extract the pulse shape, as well as reveal the level of noise it possesses. Noise reduction is then carried out numerically. We conclude that this can be accomplished physically via the addition of properly designed well-mixing flow-reversal cell(s as an integral part of the flow system. This approach should enable improved networking capabilities and potentially not only digital but analog signal-processing in such systems. Possible applications in complex biocomputing networks and various sense-and-act systems are discussed.

  17. Design of Flow Systems for Improved Networking and Reduced Noise in Biomolecular Signal Processing in Biocomputing and Biosensing Applications.

    Science.gov (United States)

    Verma, Arjun; Fratto, Brian E; Privman, Vladimir; Katz, Evgeny

    2016-07-05

    We consider flow systems that have been utilized for small-scale biomolecular computing and digital signal processing in binary-operating biosensors. Signal measurement is optimized by designing a flow-reversal cuvette and analyzing the experimental data to theoretically extract the pulse shape, as well as reveal the level of noise it possesses. Noise reduction is then carried out numerically. We conclude that this can be accomplished physically via the addition of properly designed well-mixing flow-reversal cell(s) as an integral part of the flow system. This approach should enable improved networking capabilities and potentially not only digital but analog signal-processing in such systems. Possible applications in complex biocomputing networks and various sense-and-act systems are discussed.

  18. Systematic Prediction of Scaffold Proteins Reveals New Design Principles in Scaffold-Mediated Signal Transduction

    Science.gov (United States)

    Hu, Jianfei; Neiswinger, Johnathan; Zhang, Jin; Zhu, Heng; Qian, Jiang

    2015-01-01

    Scaffold proteins play a crucial role in facilitating signal transduction in eukaryotes by bringing together multiple signaling components. In this study, we performed a systematic analysis of scaffold proteins in signal transduction by integrating protein-protein interaction and kinase-substrate relationship networks. We predicted 212 scaffold proteins that are involved in 605 distinct signaling pathways. The computational prediction was validated using a protein microarray-based approach. The predicted scaffold proteins showed several interesting characteristics, as we expected from the functionality of scaffold proteins. We found that the scaffold proteins are likely to interact with each other, which is consistent with previous finding that scaffold proteins tend to form homodimers and heterodimers. Interestingly, a single scaffold protein can be involved in multiple signaling pathways by interacting with other scaffold protein partners. Furthermore, we propose two possible regulatory mechanisms by which the activity of scaffold proteins is coordinated with their associated pathways through phosphorylation process. PMID:26393507

  19. Direction of Radio Finding via MUSIC (Multiple Signal Classification) Algorithm for Hardware Design System

    Science.gov (United States)

    Zhang, Zheng

    2017-10-01

    Concept of radio direction finding systems, which use radio direction finding is based on digital signal processing algorithms. Thus, the radio direction finding system becomes capable to locate and track signals by the both. Performance of radio direction finding significantly depends on effectiveness of digital signal processing algorithms. The algorithm uses the Direction of Arrival (DOA) algorithms to estimate the number of incidents plane waves on the antenna array and their angle of incidence. This manuscript investigates implementation of the DOA algorithms (MUSIC) on the uniform linear array in the presence of white noise. The experiment results exhibit that MUSIC algorithm changed well with the radio direction.

  20. On the Design of an Efficient Cardiac Health Monitoring System Through Combined Analysis of ECG and SCG Signals.

    Science.gov (United States)

    Sahoo, Prasan Kumar; Thakkar, Hiren Kumar; Lin, Wen-Yen; Chang, Po-Cheng; Lee, Ming-Yih

    2018-01-28

    Cardiovascular disease (CVD) is a major public concern and socioeconomic problem across the globe. The popular high-end cardiac health monitoring systems such as magnetic resonance imaging (MRI), computerized tomography scan (CT scan), and echocardiography (Echo) are highly expensive and do not support long-term continuous monitoring of patients without disrupting their activities of daily living (ADL). In this paper, the continuous and non-invasive cardiac health monitoring using unobtrusive sensors is explored aiming to provide a feasible and low-cost alternative to foresee possible cardiac anomalies in an early stage. It is learned that cardiac health monitoring based on sole usage of electrocardiogram (ECG) signals may not provide powerful insights as ECG provides shallow information on various cardiac activities in the form of electrical impulses only. Hence, a novel low-cost, non-invasive seismocardiogram (SCG) signal along with ECG signals are jointly investigated for the robust cardiac health monitoring. For this purpose, the in-laboratory data collection model is designed for simultaneous acquisition of ECG and SCG signals followed by mechanisms for the automatic delineation of relevant feature points in acquired ECG and SCG signals. In addition, separate feature points based novel approach is adopted to distinguish between normal and abnormal morphology in each ECG and SCG cardiac cycle. Finally, a combined analysis of ECG and SCG is carried out by designing a Naïve Bayes conditional probability model. Experiments on Institutional Review Board (IRB) approved licensed ECG/SCG signals acquired from real subjects containing 12,000 cardiac cycles show that the proposed feature point delineation mechanisms and abnormal morphology detection methods consistently perform well and give promising results. In addition, experimental results show that the combined analysis of ECG and SCG signals provide more reliable cardiac health monitoring compared to the

  1. Design and Evaluation of a Mathematical Optimization Model for Traffic Signal Plan Transition Based on Social Cost Function

    Directory of Open Access Journals (Sweden)

    Rita Peñabaena-Niebles

    2017-01-01

    Full Text Available Signal plan transition is the process of changing from one timing plan to another. It begins when the first intersection starts adjusting signal timing plans and ends when the last intersection completes adjusting signal timing plans. The transition between signal timing plans is required because traffic patterns change during the day. Therefore, it is necessary to modify signal timing parameters offset, phase split, and cycle length for different expectations of traffic volume. This paper presents an alternative and new mathematical model to enhance the performance of traffic signals coordination at intersections during the transition phase. This model is oriented to describe the transition regarding coordination parameters in all intersections of an arterial road for minimizing the social cost during the transition phase expressed in function of costs due to delays, fuel consumption, and air emissions. An ant colony algorithm was designed, coded, and simulated to find the optimal transition parameters using available data. The model was evaluated based on its ability to minimize social costs during the transition period. Results showed that the proposed method performs better than traditional ones.

  2. Operation, analysis, and design of signalized intersections : a module for the introductory course in transportation engineering.

    Science.gov (United States)

    2014-02-01

    This report presents materials that can be used as the basis for a module on signalized intersections in the introductory : course in transportation engineering. The materials were developed based on studies of the work of students who took : this in...

  3. Fatigue Resistant Design Criteria for MD SHA Cantilevered Mast Arm Signal Structure : Research Summary

    Science.gov (United States)

    2017-12-01

    Over the past two decades, wind induced fatigue cracking of highway signs, luminaires, and traffic signal support structures have been increasingly reported all over the United States. While fatalities associated with these failures have been limited...

  4. Advanced Signaling Support for IP-based Networks

    OpenAIRE

    Röhricht, Martin

    2013-01-01

    This work develops a set of advanced signaling concepts for IP-based networks. It proposes a design for secure and authentic signaling and provides QoS signaling support for mobile users. Furthermore, this work develops methods which allow for scalable QoS signaling by realizing QoS-based group communication mechanisms and through aggregation of resource reservations.

  5. Transmission and signal loss in mask designs for a dual neutron and gamma imager applied to mobile standoff detection

    International Nuclear Information System (INIS)

    Ayaz-Maierhafer, Birsen; Hayward, Jason P.; Ziock, Klaus P.; Blackston, Matthew A.; Fabris, Lorenzo

    2013-01-01

    In order to design a next-generation, dual neutron and gamma imager for mobile standoff detection which uses coded aperture imaging as its primary detection modality, the following design parameters have been investigated for gamma and neutron radiation incident upon a hybrid, coded mask: (1) transmission through mask elements for various mask materials and thicknesses; and (2) signal attenuation in the mask versus angle of incidence. Each of these parameters directly affects detection significance, as quantified by the signal-to-noise ratio. The hybrid mask consists of two or three layers: organic material for fast neutron attenuation and scattering, Cd for slow neutron absorption (if applied), and one of three of the following photon or photon and slow neutron attenuating materials—Linotype alloy, CLYC, or CZT. In the MCNP model, a line source of gamma rays (100–2500 keV), fast neutrons (1000–10,000 keV) or thermal neutrons was positioned above the hybrid mask. The radiation penetrating the mask was simply tallied at the surface of an ideal detector, which was located below the surface of the last mask layer. The transmission was calculated as the ratio of the particles transmitted through the fixed aperture to the particles passing through the closed mask. In order to determine the performance of the mask considering relative motion between the source and detector, simulations were used to calculate the signal attenuation for incident radiation angles of 0–50°. The results showed that a hybrid mask can be designed to sufficiently reduce both transmission through the mask and signal loss at large angles of incidence, considering both gamma ray and fast neutron radiations. With properly selected material thicknesses, the signal loss of a hybrid mask, which is necessarily thicker than the mask required for either single mode imaging, is not a setback to the system's detection significance

  6. Exploiting the 1/f structure of neural signals for the design of integrated neural amplifiers.

    Science.gov (United States)

    Venkatraman, Subramaniam; Patten, Craig; Carmena, Jose M

    2009-01-01

    Neural amplifiers require a large time-constant high-pass filter at approximately 1Hz to reject large DC offsets while amplifying low frequency neural signals. This high pass filter is typically realized using large area capacitors and teraohm resistances which makes integration difficult. In this paper, we present a novel topology for a neural amplifier which exploits the (1/f)(n) power spectra of local field potentials (LFP). Using a high-pass filter at approximately 100Hz, we pre-filter the LFP before amplification. Post digitization, we can recover the LFP signal by building the inverse of the high pass filter in software. We built an array of neural amplifiers based on this principle and tested it on rats chronically implanted with microelectrode arrays. We found that we could recover the initial LFP signal and the power spectral information over time with correlation coefficient greater than 0.94.

  7. Fatigue Resistant Design Criteria for MD SHA Cantilevered Mast Arm Signal Structure

    Science.gov (United States)

    2017-12-01

    The fatigue design of the mast arm structures and connections vary significantly based on the Category of Importance factor adopted and the load cases for fatigue design loads. Consideration should include the cost and size of the structures for both...

  8. Design reuse in product shape modeling : A study of freeform feature reuse by signal processing techniques

    NARCIS (Netherlands)

    Wang, C.

    2005-01-01

    Lack of facilities in supporting design reuse is a serious problem in product shape modeling, especially in computer-aided design systems. This becomes a bottleneck of fast shape conceptualization and creation in consumer product design, which consequently prohibits creativity and innovation. In the

  9. Signal-to-Noise ratio and design complexity based on Unified Loss ...

    African Journals Online (AJOL)

    Taguchi's quality loss function for larger-the-better performance characteristics uses a reciprocal transformation to compute quality loss. This paper suggests that reciprocal transformation unnecessarily complicates and may distort results. Examples of this distortion include the signal-to-noise ratio based on mean squared ...

  10. A Platform-Based Methodology for System-Level Mixed-Signal Design

    Directory of Open Access Journals (Sweden)

    Alberto Sangiovanni-Vincentelli

    2010-01-01

    Full Text Available The complexity of today's embedded electronic systems as well as their demanding performance and reliability requirements are such that their design can no longer be tackled with ad hoc techniques while still meeting tight time to-market constraints. In this paper, we present a system level design approach for electronic circuits, utilizing the platform-based design (PBD paradigm as the natural framework for mixed-domain design formalization. In PBD, a meet-in-the-middle approach allows systematic exploration of the design space through a series of top-down mapping of system constraints onto component feasibility models in a platform library, which is based on bottom-up characterizations. In this framework, new designs can be assembled from the precharacterized library components, giving the highest priority to design reuse, correct assembly, and efficient design flow from specifications to implementation. We apply concepts from design centering to enforce robustness to modeling errors as well as process, voltage, and temperature variations, which are currently plaguing embedded system design in deep-submicron technologies. The effectiveness of our methodology is finally shown on the design of a pipeline A/D converter and two receiver front-ends for UMTS and UWB communications.

  11. Design and Analysis of a New Hair Sensor for Multi-Physical Signal Measurement

    Directory of Open Access Journals (Sweden)

    Bo Yang

    2016-07-01

    Full Text Available A new hair sensor for multi-physical signal measurements, including acceleration, angular velocity and air flow, is presented in this paper. The entire structure consists of a hair post, a torsional frame and a resonant signal transducer. The hair post is utilized to sense and deliver the physical signals of the acceleration and the air flow rate. The physical signals are converted into frequency signals by the resonant transducer. The structure is optimized through finite element analysis. The simulation results demonstrate that the hair sensor has a frequency of 240 Hz in the first mode for the acceleration or the air flow sense, 3115 Hz in the third and fourth modes for the resonant conversion, and 3467 Hz in the fifth and sixth modes for the angular velocity transformation, respectively. All the above frequencies present in a reasonable modal distribution and are separated from interference modes. The input-output analysis of the new hair sensor demonstrates that the scale factor of the acceleration is 12.35 Hz/g, the scale factor of the angular velocity is 0.404 nm/deg/s and the sensitivity of the air flow is 1.075 Hz/(m/s2, which verifies the multifunction sensitive characteristics of the hair sensor. Besides, the structural optimization of the hair post is used to improve the sensitivity of the air flow rate and the acceleration. The analysis results illustrate that the hollow circular hair post can increase the sensitivity of the air flow and the II-shape hair post can increase the sensitivity of the acceleration. Moreover, the thermal analysis confirms the scheme of the frequency difference for the resonant transducer can prominently eliminate the temperature influences on the measurement accuracy. The air flow analysis indicates that the surface area increase of hair post is significantly beneficial for the efficiency improvement of the signal transmission. In summary, the structure of the new hair sensor is proved to be feasible by

  12. Design and Analysis of a New Hair Sensor for Multi-Physical Signal Measurement.

    Science.gov (United States)

    Yang, Bo; Hu, Di; Wu, Lei

    2016-07-08

    A new hair sensor for multi-physical signal measurements, including acceleration, angular velocity and air flow, is presented in this paper. The entire structure consists of a hair post, a torsional frame and a resonant signal transducer. The hair post is utilized to sense and deliver the physical signals of the acceleration and the air flow rate. The physical signals are converted into frequency signals by the resonant transducer. The structure is optimized through finite element analysis. The simulation results demonstrate that the hair sensor has a frequency of 240 Hz in the first mode for the acceleration or the air flow sense, 3115 Hz in the third and fourth modes for the resonant conversion, and 3467 Hz in the fifth and sixth modes for the angular velocity transformation, respectively. All the above frequencies present in a reasonable modal distribution and are separated from interference modes. The input-output analysis of the new hair sensor demonstrates that the scale factor of the acceleration is 12.35 Hz/g, the scale factor of the angular velocity is 0.404 nm/deg/s and the sensitivity of the air flow is 1.075 Hz/(m/s)², which verifies the multifunction sensitive characteristics of the hair sensor. Besides, the structural optimization of the hair post is used to improve the sensitivity of the air flow rate and the acceleration. The analysis results illustrate that the hollow circular hair post can increase the sensitivity of the air flow and the II-shape hair post can increase the sensitivity of the acceleration. Moreover, the thermal analysis confirms the scheme of the frequency difference for the resonant transducer can prominently eliminate the temperature influences on the measurement accuracy. The air flow analysis indicates that the surface area increase of hair post is significantly beneficial for the efficiency improvement of the signal transmission. In summary, the structure of the new hair sensor is proved to be feasible by comprehensive

  13. Antenna and coil design for wireless signal detection and charging of embedded power active contact lens.

    Science.gov (United States)

    Ng, Benny; Heckler, Paul; Do, Alex; Azar, Phillip; Leon, Errol; Smilkstein, Tina

    2014-01-01

    This paper presents a screen printed 2.4 GHz antenna and induction charging coil for an active contact lens with a single large pixel user display and on-board 3.8 V 5 uAh rechargeable battery. The antenna traces are printed using silver conductive paste on a 25 um polyethylene terephthalate (PET) substrate. The incoming signal from the antenna feeds into an IC that amplifies and rectifies the signal. The coil provides wireless energy transfer to inductively charge a thin film battery [1] located on the contact lens. The printed antenna achieved a S11 of -4 dB at 2.4 GHz and a gain of -13 dB.

  14. The Role of Diet in Shaping the Chemical Signal Design of Lacertid Lizards.

    Science.gov (United States)

    Baeckens, Simon; García-Roa, Roberto; Martín, José; Van Damme, Raoul

    2017-09-01

    Lizards communicate with others via chemical signals, the composition of which may vary among species. Although the selective pressures and constraints affecting chemical signal diversity at the species level remain poorly understood, the possible role of diet has been largely neglected. The chemical signals of many lizards originate from the femoral glands that exude a mixture of semiochemicals, and may be used in a variety of contexts. We analyzed the lipophilic fraction of the glandular secretions of 45 species of lacertid lizard species by gas chromatography/mass spectrometry. The proportions of nine major chemical classes (alcohols, aldehydes, fatty acids, furanones, ketones, steroids, terpenoids, tocopherols and waxy esters), the relative contributions of these different classes ('chemical diversity'), and the total number of different lipophilic compounds ('chemical richness') varied greatly among species. We examined whether interspecific differences in these chemical variables could be coupled to interspecific variation in diet using data from the literature. In addition, we compared chemical signal composition among species that almost never, occasionally, or often eat plant material. We found little support for the hypothesis that the chemical profile of a given species' secretion depends on the type of food consumed. Diet breadth did not correlate with chemical diversity or richness. The amount of plants or ants consumed did not affect the relative contribution of any of the nine major chemical classes to the secretion. Chemical diversity did not differ among lizards with different levels of plant consumption; however, chemical richness was low in species with an exclusive arthropod diet, suggesting that incorporating plants in the diet enables lizards to increase the number of compounds allocated to secretions, likely because a (partly) herbivorous diet allows them to include compounds of plant origin that are unavailable in animal prey. Still, overall

  15. Signal Processing Design of Low Probability of Intercept Waveforms via Intersymbol Dither

    Science.gov (United States)

    2008-03-01

    Two cooperative receiver strategies are proposed to mitigate the ISI due to symbol timing offset: a modified minimum Mean Square Error ( MMSE ...a linear time- invariant system characterized by the overall channel impulse response h(t) which 2-2 Filter Downsample Channel Noise Sample DAC PSfrag...filter is a linear time- invariant system defined by its discrete impulse response w′ which acts on the received signal samples y′(k) to produce an

  16. Signal design and perception in Hypocnemis antbirds: evidence for convergent evolution via social selection.

    Science.gov (United States)

    Tobias, Joseph A; Seddon, Nathalie

    2009-12-01

    Natural selection is known to produce convergent phenotypes through mimicry or ecological adaptation. It has also been proposed that social selection--i.e., selection exerted by social competition--may drive convergent evolution in signals mediating interspecific communication, yet this idea remains controversial. Here, we use color spectrophotometry, acoustic analyses, and playback experiments to assess the hypothesis of adaptive signal convergence in two competing nonsister taxa, Hypocnemis peruviana and H. subflava (Aves: Thamnophilidae). We show that the structure of territorial songs in males overlaps in sympatry, with some evidence of convergent character displacement. Conversely, nonterritorial vocal and visual signals in males are strikingly diagnostic, in line with 6.8% divergence in mtDNA sequences. The same pattern of variation applies to females. Finally, we show that songs in both sexes elicit strong territorial responses within and between species, whereas songs of a third, allopatric and more closely related species (H. striata) are structurally divergent and elicit weaker responses. Taken together, our results provide compelling evidence that social selection can act across species boundaries to drive convergent or parallel evolution in taxa competing for space and resources.

  17. Quantification, modelling and design for signal history dependent effects in mixed-signal SOI/SOS circuits; Quantification, modelisation et conception prenant en compte les etats anterieurs des signaux dans les circuits mixtes SOI/SOS

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, C.F.; Redman-White, W.; Bracey, M.; Tenbroek, B.M.; Lee, M.S. [Southampton Univ., Dept. of Electronics and Computer Sciences (United Kingdom); Uren, M.J.; Brunson, K.M. [DERA Farnborough, GU, Hants (United Kingdom)

    1999-07-01

    This paper deals with how the radiation hardness of mixed signal SOI/SOS CMOS circuits is taken into account at both architectural terms as well as the the transistor level cell designs. The primary issue is to deal with divergent transistor threshold shifts, and to understand the effects of large amplitude non stationary signals on analogue cell behaviour. (authors)

  18. Instantaneous Wave-Free Ratio versus Fractional Flow Reserve guided intervention (iFR-SWEDEHEART): Rationale and design of a multicenter, prospective, registry-based randomized clinical trial.

    Science.gov (United States)

    Götberg, Matthias; Christiansen, Evald H; Gudmundsdottir, Ingibjörg; Sandhall, Lennart; Omerovic, Elmir; James, Stefan K; Erlinge, David; Fröbert, Ole

    2015-11-01

    Instantaneous wave-free ratio (iFR) is a new hemodynamic resting index for assessment of coronary artery stenosis severity. iFR uses high frequency sampling to calculate a gradient across a coronary lesion during a period of diastole. The index has been tested against fractional flow reserve (FFR) and found to have an overall classification agreement of 80% to 85%. Whether the level of disagreement is clinically relevant is unknown. Clinical outcome data on iFR are scarce. This study is a registry-based randomized clinical trial, which is a novel strategy using health quality registries as on-line platforms for randomization, case record forms, and follow-up. iFR-SWEDEHEART is a multicenter, prospective, randomized, controlled, clinical open-label clinical trial. Two thousand patients with stable angina or acute coronary syndrome and an indication for physiology-guided assessment of one or more coronary stenoses will be randomized 1:1 to either iFR- or FFR-guided intervention. The randomization will be conducted online in the Swedish web-based system for enhancement and development of evidence-based care in heart disease evaluated according to recommended therapies (SWEDEHEART) registry. The trial has a non-inferiority design, with a primary combined end point of all-cause death, non-fatal myocardial infarction, and unplanned revascularization at 12 months. End points will be identified through national registries and undergo central blind adjudication to ensure data quality. The iFR-SWEDEHEART trial is an registry-based randomized clinical trial evaluating the safety and efficacy of the diagnostic method iFR compared to FFR. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Efficient design of FIR filter based low-pass differentiators for biomedical signal processing

    Directory of Open Access Journals (Sweden)

    Wulf Michael

    2016-09-01

    Full Text Available This paper describes an alternative design of linear phase low-pass differentiators with a finite impulse response (type III FIR filter. To reduce the number of necessary filter coefficients, the differentiator’s transfer function is approximated by a Fourier series of a triangle function. Thereby the filter’s transition steepness towards the stopband is intentionally reduced. It can be shown that the proposed design of low-pass differentiators yields to similar results as other published design recommendations, while the filter order can be significantly reduced.

  20. Design, Development and Implementation of the IR Signalling Techniques for Monitoring Ambient and Body Temperature in WBANs

    Directory of Open Access Journals (Sweden)

    Attiya Baqai

    2014-07-01

    Full Text Available Healthcare systems such as hospitals, homecare, telemedicine, and physical rehabilitation are expected to be revolutionized by WBAN (Wireless Body Area Networks. This research work aims to investigate, design, optimize, and demonstrate the applications of IR (Infra-Red communication systems in WBAN. It is aimed to establish a prototype WBAN system capable of measuring Ambient and Body Temperature using LM35 as temperature sensor and transmitting and receiving the data using optical signals. The corresponding technical challenges that have to be faced are also discussed in this paper. Investigations are carried out to efficiently design the hardware using low-cost and low power optical transceivers. The experimental results reveal the successful transmission and reception of Ambient and Body Temperatures over short ranges i.e. up to 3-4 meters. A simple IR transceiver with an LED (Light Emitting Diodes, TV remote control IC and Arduino microcontroller is designed to perform the transmission with sufficient accuracy and ease. Experiments are also performed to avoid interference from other sources like AC and TV remote control signals by implementing IR tags

  1. Designing BEE: A Hardware Emulation Engine for Signal Processing in Low-Power Wireless Applications

    Directory of Open Access Journals (Sweden)

    Chang Chen

    2003-01-01

    Full Text Available This paper describes the design of a large-scale emulation engine and an application example from the field of low-power wireless devices. The primary goal of the emulator is to support design space exploration of real-time algorithms. The emulator is customized for dataflow dominant architectures, especially focusing on telecommunication-related applications. Due to its novel routing architecture and application-specific nature, the emulator is capable of real-time execution of a class of algorithms in its application space. Moreover, the dataflow structure facilitates the development of a highly abstracted design flow for the emulator. Simulations and practical measurements on commercial development boards are used to verify that real-time emulation of a low-power TDMA receiver is feasible at a clock speed of 25 MHz.

  2. SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling.

    Science.gov (United States)

    Zhou, Xiao-Ling; Xu, Jin-Jie; Ni, Yan-Hong; Chen, Xiao-Chun; Zhang, Hong-Xia; Zhang, Xing-Mei; Liu, Wei-Juan; Luo, Li-Li; Fu, Yu-Cai

    2014-10-21

    The prevalence of obesity is increasing worldwide and significantly affects fertility and reproduction in both men and women. Our recent study has shown that excess body fat accelerates ovarian follicle development and follicle loss in rats. The aim of the present study is to explore the effect of SIRT1 activator SRT1720 on the reserve of ovarian follicle pool and ovarian lifespan of obese mice and the underlying mechanism associated with SIRT1 and mTOR signaling. Adult female Kunming mice (n = 36) were randomly divided into three groups: the normal control (NC) group (n = 8), the caloric restriction (CR) group (fed 70% food of the NC group, n = 8) and the high-fat diet (HF) group (fed a rodent chow containing 20% fat, n = 20). After 4 months, the HF mice were further randomly divided into three groups: the control high-fat diet (CHF, n = 8) group (treated every day with an intraperitoneal injection of vehicle), the SRT1720 (SRT, n = 6) group (treated every other day with an intraperitoneal injection of SRT1720 (50 mg/kg)), the SRT1720 and nicotinamide (NAM, n = 6) group (treated every other day with an intraperitoneal injection of SRT1720 (50 mg/kg) and every day with an intraperitoneal injection of nicotinamide (100 mg/kg)). After 6 weeks of treatment, ovaries were harvested for histological and Western blotting analyses. The body weight, ovary weight and visceral fat in the SRT group were significantly lower than those in the CHF group at the end of treatment. Histological analysis showed that the SRT mice had significantly greater number and percentage of primordial follicles, but lower number and percentage of corpora lutea and atretic follicles than the CHF mice and NAM mice. Western blot analysis demonstrated that the levels of SIRT1, SIRT6, FOXO3a and NRF-1 protein expression significantly increased in the ovaries of SRT mice, whereas those of mTORC1, p-mTOR, p-p70S6K, NFκB and p53 decreased compared to the CHF and NAM mice. Our study suggests that

  3. A signal pre-processing algorithm designed for the needs of hardware implementation of neural classifiers used in condition monitoring

    DEFF Research Database (Denmark)

    Dabrowski, Dariusz; Hashemiyan, Zahra; Adamczyk, Jan

    2015-01-01

    Gearboxes have a significant influence on the durability and reliability of a power transmission system. Currently, extensive research studies are being carried out to increase the reliability of gearboxes working in the energy industry, especially with a focus on planetary gears in wind turbines...... and bucket wheel excavators. In this paper, a signal pre-processing algorithm designed for condition monitoring of planetary gears working in non-stationary operation is presented. The algorithm is dedicated for hardware implementation on Field Programmable Gate Arrays (FPGAs). The purpose of the algorithm...

  4. The Design and Use of an Optical Mapping System for the Study of Intracardiac Electrical Signaling

    Directory of Open Access Journals (Sweden)

    Maneesh Shrivastav, PhD

    2012-07-01

    Full Text Available Fluorescent optical mapping of electrically active cardiac tissues provides a unique method to examine the excitation wave dynamics of underlying action potentials. Such mapping can be viewed as a bridge between cellular level and organ systems physiology, e.g., by facilitating the development of advanced theoretical concepts of arrhythmia. We present the design and use of a high-speed, high-resolution optical mapping system composed entirely of “off the shelf” components. The electrical design integrates a 256 element photodiode array with a 16 bit data acquisition system. Proper grounding and shielding at various stages of the design reduce electromagnetic interference. Our mechanical design provides flexibility in terms of mounting positions and applications (use for whole heart or tissue preparations, while maintaining precise alignment between all optical components. The system software incorporates a user friendly graphical user interface, e.g., spatially recorded action potentials can be represented as intensity graphs or in strip chart format. Thus, this system is capable of displaying cardiac action potentials with high spatiotemporal resolution. Results from cardiac action potential mapping with intact mouse hearts are provided. It should be noted that this system could be readily configured to study isolated myocardial biopsies (e.g., isolated ventricular trabeculae. We describe the details of a versatile, user-friendly system that could be employed for a magnitude of study protocols.

  5. Design and implementation of a reconfigurable mixed-signal SoC based on field programmable analog arrays

    Science.gov (United States)

    Liu, Lintao; Gao, Yuhan; Deng, Jun

    2017-11-01

    This work presents a reconfigurable mixed-signal system-on-chip (SoC), which integrates switched-capacitor-based field programmable analog arrays (FPAA), analog-to-digital converter (ADC), digital-to-analog converter, digital down converter , digital up converter, 32-bit reduced instruction-set computer central processing unit (CPU) and other digital IPs on a single chip with 0.18 μm CMOS technology. The FPAA intellectual property could be reconfigured as different function circuits, such as gain amplifier, divider, sine generator, and so on. This single-chip integrated mixed-signal system is a complete modern signal processing system, occupying a die area of 7 × 8 mm 2 and consuming 719 mW with a clock frequency of 150 MHz for CPU and 200 MHz for ADC/DAC. This SoC chip can help customers to shorten design cycles, save board area, reduce the system power consumption and depress the system integration risk, which would afford a big prospect of application for wireless communication. Project supported by the National High Technology and Development Program of China (No. 2012AA012303).

  6. Design of Low Power Algorithms for Automatic Embedded Analysis of Patch ECG Signals

    DEFF Research Database (Denmark)

    Saadi, Dorthe Bodholt

    , several different cable-free wireless patch-type ECG recorders have recently reached the market. One of these recorders is the ePatch designed by the Danish company DELTA. The extended monitoring period available with the patch recorders has demonstrated to increase the diagnostic yield of outpatient ECG...... monitoring. Furthermore, the patch recorders facilitate the possibility of outpatient ECG monitoring in new clinically relevant areas, e.g. telemedicine monitoring of cardiac patients in their homes. Some of these new applications could benefit from real-time embedded interpretation of the recorded ECGs....... Such algorithms could allow the real-time transmission of clinically relevant information to a central monitoring station. The first step in embedded ECG interpretation is the automatic detection of each individual heartbeat. An important part of this project was therefore to design a novel algorithm...

  7. Neural network screening of electromyographic signals as the first phase to design novel human-computer interaction.

    Science.gov (United States)

    Niemenlehto, Pekka-Henrik; Juhola, Martti; Surakka, Veikko

    2005-01-01

    The present aim was to describe the first phase attempts to recognise voluntarily produced changes in electromyographic signals measured from two facial muscles. Thirty subjects voluntarily activated two facial muscles, corrugator supercilii and zygomaticus major. We designed a neural network based recognition system that screened out muscle activations from the electromyographic signals. When several subjects were tested according to the same test protocol, the neural network system was able to correctly recognise more than 95 % of all muscle activations. This is a promising result and we shall next proceed to modify the system for real-time functioning and then design its utilisation for various multimodal human-computer interaction techniques. The subsequent phase in the future will be the interaction backwards: when a computer program first recognised the use of the facial muscles, it will then follow the instructions given by the user. For instance, by using the facial muscles the subject could select or activate objects on the computer screen. This would be one of the opportunities that we develop to help, e.g., disabled persons, who are unable to use their hands.

  8. The Singular Value Filter: A General Filter Design Strategy for PCA-Based Signal Separation in Medical Ultrasound Imaging

    Science.gov (United States)

    Lin, Dan; Hossack, John A.

    2012-01-01

    A general filtering method, called the singular value filter (SVF), is presented as a framework for principal component analysis (PCA) based filter design in medical ultrasound imaging. The SVF approach operates by projecting the original data onto a new set of bases determined from PCA using singular value decomposition (SVD). The shape of the SVF weighting function, which relates the singular value spectrum of the input data to the filtering coefficients assigned to each basis function, is designed in accordance with a signal model and statistical assumptions regarding the underlying source signals. In this paper, we applied SVF for the specific application of clutter artifact rejection in diagnostic ultrasound imaging. SVF was compared to a conventional PCA-based filtering technique, which we refer to as the blind source separation (BSS) method, as well as a simple frequency-based finite impulse response (FIR) filter used as a baseline for comparison. The performance of each filter was quantified in simulated lesion images as well as experimental cardiac ultrasound data. SVF was demonstrated in both simulation and experimental results, over a wide range of imaging conditions, to outperform the BSS and FIR filtering methods in terms of contrast-to-noise ratio (CNR) and motion tracking performance. In experimental mouse heart data, SVF provided excellent artifact suppression with an average CNR improvement of 1.8 dB (P filtering was achieved using complex pulse-echo received data and non-binary filter coefficients. PMID:21693416

  9. Adaptive digital notch filter design on the unit circle for the removal of powerline noise from biomedical signals.

    Science.gov (United States)

    Ferdjallah, M; Barr, R E

    1994-06-01

    This paper investigates adaptive digital notch filters for the elimination of powerline noise from biomedical signals. Since the distribution of the frequency variation of the powerline noise may or may not be centered at 60 Hz, three different adaptive digital notch filters are considered. For the first case, an adaptive FIR second-order digital notch filter is designed to track the center frequency variation. For the second case, the zeroes of an adaptive IIR second-order digital notch filter are fixed on the unit circle and the poles are adapted to find an optimum bandwidth to eliminate the noise to a pre-defined attenuation level. In the third case, both the poles and zeroes of the adaptive IIR second-order filter are adapted to track the center frequency variation within an optimum bandwidth. The adaptive process is considerably simplified by designing the notch filters by pole-zero placement on the unit circle using some suggested rules. A constrained least mean-squared (CLMS) algorithm is used for the adaptive process. To evaluate their performance, the three adaptive notch filters are applied to a powerline noise sample and to a noisy EEG as an illustration of a biomedical signal.

  10. Design and implementation of multi-signal and time-varying neural reconstructions.

    Science.gov (United States)

    Nanda, Sumit; Chen, Hanbo; Das, Ravi; Bhattacharjee, Shatabdi; Cuntz, Hermann; Torben-Nielsen, Benjamin; Peng, Hanchuan; Cox, Daniel N; De Schutter, Erik; Ascoli, Giorgio A

    2018-01-23

    Several efficient procedures exist to digitally trace neuronal structure from light microscopy, and mature community resources have emerged to store, share, and analyze these datasets. In contrast, the quantification of intracellular distributions and morphological dynamics is not yet standardized. Current widespread descriptions of neuron morphology are static and inadequate for subcellular characterizations. We introduce a new file format to represent multichannel information as well as an open-source Vaa3D plugin to acquire this type of data. Next we define a novel data structure to capture morphological dynamics, and demonstrate its application to different time-lapse experiments. Importantly, we designed both innovations as judicious extensions of the classic SWC format, thus ensuring full back-compatibility with popular visualization and modeling tools. We then deploy the combined multichannel/time-varying reconstruction system on developing neurons in live Drosophila larvae by digitally tracing fluorescently labeled cytoskeletal components along with overall dendritic morphology as they changed over time. This same design is also suitable for quantifying dendritic calcium dynamics and tracking arbor-wide movement of any subcellular substrate of interest.

  11. A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer: design and methodological challenges

    Directory of Open Access Journals (Sweden)

    Overbeek Annelies

    2012-08-01

    Full Text Available Abstract Background Advances in childhood cancer treatment over the past decades have significantly improved survival, resulting in a rapidly growing group of survivors. However, both chemo- and radiotherapy may adversely affect reproductive function. This paper describes the design and encountered methodological challenges of a nationwide study in the Netherlands investigating the effects of treatment on reproductive function, ovarian reserve, premature menopause and pregnancy outcomes in female childhood cancer survivors (CCS, the DCOG LATER-VEVO study. Methods The study is a retrospective cohort study consisting of two parts: a questionnaire assessing medical, menstrual, and obstetric history, and a clinical assessment evaluating ovarian and uterine function by hormonal analyses and transvaginal ultrasound measurements. The eligible study population consists of adult female 5-year survivors of childhood cancer treated in the Netherlands, whereas the control group consists of age-matched sisters of the participating CCS. To date, study invitations have been sent to 1611 CCS and 429 sister controls, of which 1215 (75% and 333 (78% have responded so far. Of these responders, the majority consented to participate in both parts of the study (53% vs. 65% for CCS and sister controls respectively. Several challenges were encountered involving the study population: dealing with bias due to the differences in characteristics of several types of (non- participants and finding an adequately sized and well-matched control group. Moreover, the challenges related to the data collection process included: differences in response rates between web-based and paper-based questionnaires, validity of self-reported outcomes, interpretation of clinical measurements of women using hormonal contraceptives, and inter- and intra-observer variation of the ultrasound measurements. Discussion The DCOG LATER-VEVO study will provide valuable information about the

  12. A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer: design and methodological challenges

    Science.gov (United States)

    2012-01-01

    Background Advances in childhood cancer treatment over the past decades have significantly improved survival, resulting in a rapidly growing group of survivors. However, both chemo- and radiotherapy may adversely affect reproductive function. This paper describes the design and encountered methodological challenges of a nationwide study in the Netherlands investigating the effects of treatment on reproductive function, ovarian reserve, premature menopause and pregnancy outcomes in female childhood cancer survivors (CCS), the DCOG LATER-VEVO study. Methods The study is a retrospective cohort study consisting of two parts: a questionnaire assessing medical, menstrual, and obstetric history, and a clinical assessment evaluating ovarian and uterine function by hormonal analyses and transvaginal ultrasound measurements. The eligible study population consists of adult female 5-year survivors of childhood cancer treated in the Netherlands, whereas the control group consists of age-matched sisters of the participating CCS. To date, study invitations have been sent to 1611 CCS and 429 sister controls, of which 1215 (75%) and 333 (78%) have responded so far. Of these responders, the majority consented to participate in both parts of the study (53% vs. 65% for CCS and sister controls respectively). Several challenges were encountered involving the study population: dealing with bias due to the differences in characteristics of several types of (non-) participants and finding an adequately sized and well-matched control group. Moreover, the challenges related to the data collection process included: differences in response rates between web-based and paper-based questionnaires, validity of self-reported outcomes, interpretation of clinical measurements of women using hormonal contraceptives, and inter- and intra-observer variation of the ultrasound measurements. Discussion The DCOG LATER-VEVO study will provide valuable information about the reproductive potential of

  13. New trends in design and fabrication of signal and power cables to increase nuclear safety

    International Nuclear Information System (INIS)

    Salmen, Florin; Florescu, Gheorghe; Ionescu, Aurel

    2007-01-01

    Based on NPP operating experiences in the past, it was found that the inadequate management of aging degradation caused shortening of the lifetime of equipment, which in turn, hindered plant life extension. Aging degradation of plant structures and components should be properly managed to ensure the designated safety function of plant systems during design life and extended life. From a safety perspective, aging management means maintaining the aging degradation level in major equipment and structures below the allowable limit and holding the capacity to sustain abnormal operating condition. Cable aging was not considered as a significant factor in relation to the nuclear power plant maintenance due to its long life which is almost the same as the plant design life. Attempts to extend the lifetime of NPP has become one of the major concern in the nuclear industry world wide. Consequently, life evaluation and lifetime management of cables to survive over 40 years has become major topic of discussion. In connection to this, accelerated aging must be studied in detail in order to simulate the natural aging in NPP. Test results for evaluating aging degradation after accelerated aging of polyethylene jacket will be described herein.There are hundred types of cables in NPPs. These cables can be classified as medium/low voltage cable, low power cable, instrument and control cable, panel connect line cable, special cable, security line cable, phone line cable and ground cable. Insulation and jacket material in electrical cables are fabricated of polymer materials combined with a number of additives and filler to provide the required mechanical, electrical and fire retardant proprieties. The most commonly used insulation materials are XLPE/EPR/EPDM and PVC. PVC has been widely used as an insulation material, particularly in old plants, but it is less used in modern plants. Neoprene/CSPE/PVC are commonly used material for nuclear cable jacket. The old types of cables

  14. Analysis, Design, and Implementation of a Logical Proof-of-Concept Prototype for Streamlining the Advertisement of Billets for the U.S. Marine Corps Reserve

    National Research Council Canada - National Science Library

    Mohler, Jon D; Thorpe, John M

    2008-01-01

    The primary objective of this thesis is to provide the Marine Corps with a thorough bottom up System Analysis of the next generation billet advertisement system that will replace Reserve Duty Online (RDOL...

  15. Design, Modelling, and Implementation of a Fuzzy Controller for an Intelligent Road Signaling System

    Directory of Open Access Journals (Sweden)

    José Manuel Lozano Domínguez

    2018-01-01

    Full Text Available Crossing points are not always 100% visible for drivers due to different factors (e.g., poor road maintenance, occlusion of vertical signs, and adverse weather conditions. USA estimated in 2015 the number of traffic accidents involving pedestrians and vehicles in 70,000 of whom 5,376 resulted in deceased people. To contribute in this field, this paper presents the design, implementation, and testing of a smart prototype system applied to pedestrian crossings—not regulated by semaphores—which try to reduce the accident rate on roads. The hardware and software system consists of a set of autonomous, intelligent, and wireless low-cost devices that generate a visual warning barrier perceived by drivers from a suitable distance when pedestrians traverse a crosswalk. In this way, drivers can reduce the speed of their vehicles and stop safely. The system’s intelligence is carried out by a fuzzy controller that performs sensory fusion at both low level and high level with various types of sensors from local and neighboring devices. The tests conducted have determined an average success of 94.64% and a precision of 100%, thus corresponding with a very good test according to a ROC analysis. As a result, the system proposed has been patented and extended to international PCT.

  16. Design of Meter-Scale Antenna and Signal Detection System for Underground Magnetic Resonance Sounding in Mines.

    Science.gov (United States)

    Yi, Xiaofeng; Zhang, Jian; Fan, Tiehu; Tian, Baofeng; Jiang, Chuandong

    2018-03-13

    Magnetic resonance sounding (MRS) is a novel geophysical method to detect groundwater directly. By applying this method to underground projects in mines and tunnels, warning information can be provided on water bodies that are hidden in front prior to excavation and thus reduce the risk of casualties and accidents. However, unlike its application to ground surfaces, the application of MRS to underground environments is constrained by the narrow space, quite weak MRS signal, and complex electromagnetic interferences with high intensities in mines. Focusing on the special requirements of underground MRS (UMRS) detection, this study proposes the use of an antenna with different turn numbers, which employs a separated transmitter and receiver. We designed a stationary coil with stable performance parameters and with a side length of 2 m, a matching circuit based on a Q-switch and a multi-stage broad/narrowband mixed filter that can cancel out most electromagnetic noise. In addition, noises in the pass-band are further eliminated by adopting statistical criteria and harmonic modeling and stacking, all of which together allow weak UMRS signals to be reliably detected. Finally, we conducted a field case study of the UMRS measurement in the Wujiagou Mine in Shanxi Province, China, with known water bodies. Our results show that the method proposed in this study can be used to obtain UMRS signals in narrow mine environments, and the inverted hydrological information generally agrees with the actual situation. Thus, we conclude that the UMRS method proposed in this study can be used for predicting hazardous water bodies at a distance of 7-9 m in front of the wall for underground mining projects.

  17. Designing informative warning signals: Effects of indicator type, modality, and task demand on recognition speed and accuracy

    Science.gov (United States)

    Stevens, Catherine J.; Brennan, David; Petocz, Agnes; Howell, Clare

    2009-01-01

    An experiment investigated the assumption that natural indicators which exploit existing learned associations between a signal and an event make more effective warnings than previously unlearned symbolic indicators. Signal modality (visual, auditory) and task demand (low, high) were also manipulated. Warning effectiveness was indexed by accuracy and reaction time (RT) recorded during training and dual task test phases. Thirty-six participants were trained to recognize 4 natural and 4 symbolic indicators, either visual or auditory, paired with critical incidents from an aviation context. As hypothesized, accuracy was greater and RT was faster in response to natural indicators during the training phase. This pattern of responding was upheld in test phase conditions with respect to accuracy but observed in RT only in test phase conditions involving high demand and the auditory modality. Using the experiment as a specific example, we argue for the importance of considering the cognitive contribution of the user (viz., prior learned associations) in the warning design process. Drawing on semiotics and cognitive psychology, we highlight the indexical nature of so-called auditory icons or natural indicators and argue that the cogniser is an indispensable element in the tripartite nature of signification. PMID:20523852

  18. Perturbation waves in proteins and protein networks: applications of percolation and game theories in signaling and drug design.

    Science.gov (United States)

    Antal, Miklós A; Böde, Csaba; Csermely, Peter

    2009-04-01

    The network paradigm is increasingly used to describe the dynamics of complex systems. Here we review the current results and propose future development areas in the assessment of perturbation waves, i.e. propagating structural changes in amino acid networks building individual protein molecules and in protein-protein interaction networks (interactomes). We assess the possibilities and critically review the initial attempts for the application of game theory to the often rather complicated process, when two protein molecules approach each other, mutually adjust their conformations via multiple communication steps and finally, bind to each other. We also summarize available data on the application of percolation theory for the prediction of amino acid network- and interactome-dynamics. Furthermore, we give an overview of the dissection of signals and noise in the cellular context of various perturbations. Finally, we propose possible applications of the reviewed methodologies in drug design.

  19. Design of an adaptive CubeSat transmitter for achieving optimum signal-to-noise ratio (SNR)

    Science.gov (United States)

    Jaswar, F. D.; Rahman, T. A.; Hindia, M. N.; Ahmad, Y. A.

    2017-12-01

    CubeSat technology has opened the opportunity to conduct space-related researches at a relatively low cost. Typical approach to maintain an affordable cubeSat mission is to use a simple communication system, which is based on UHF link with fixed-transmit power and data rate. However, CubeSat in the Low Earth Orbit (LEO) does not have relative motion with the earth rotation, resulting in variable propagation path length that affects the transmission signal. A transmitter with adaptive capability to select multiple sets of data rate and radio frequency (RF) transmit power is proposed to improve and optimise the link. This paper presents the adaptive UHF transmitter design as a solution to overcome the variability of the propagation path. The transmitter output power is adjustable from 0.5W to 2W according to the mode of operations and satellite power limitations. The transmitter is designed to have four selectable modes to achieve the optimum signal-to-noise ratio (SNR) and efficient power consumption based on the link budget analysis and satellite requirement. Three prototypes are developed and tested for space-environment conditions such as the radiation test. The Total Ionizing Dose measurements are conducted in the radiation test done at Malaysia Nuclear Agency Laboratory. The results from this test have proven that the adaptive transmitter can perform its operation with estimated more than seven months in orbit. This radiation test using gamma source with 1.5krad exposure is the first one conducted for a satellite program in Malaysia.

  20. A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer: Design and methodological challenges

    NARCIS (Netherlands)

    A. Overbeek; M.H. van den Berg (Marleen); L.C.M. Kremer (Leontien); M.M. van den Heuvel-Eibrink (Marry); W.J.E. Tissing (Wim); J.J. Loonen; B. Versluys; D. Bresters; G.J. Kaspers (Gertjan); C.B. Lambalk (Cornelius); F.E. van Leeuwen (Flora); E. van Dulmen-den Broeder (E.); C.C.M. Beerendonk (Catharina); J.P. Bökkerink (Jos); C. van den Bos (Cor); W. van Dorp (Wendy); M.P. van Engelen (M.); G.A. Huizinga (G.); M.W.M. Jaspers (Monique); J.S.E. Laven (Joop); M. Louwerens M. (M.); H.J.H. van der Pal (Heleen); C.M. Ronckers (Cécile); A.H.M. Simons; N. Tonch (Nino); E.C.M. Verkerk (E. C M)

    2012-01-01

    textabstractBackground: Advances in childhood cancer treatment over the past decades have significantly improved survival, resulting in a rapidly growing group of survivors. However, both chemo- and radiotherapy may adversely affect reproductive function. This paper describes the design and

  1. A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer : design and methodological challenges

    NARCIS (Netherlands)

    Overbeek, Annelies; van den Berg, Marleen H.; Kremer, Leontien C. M.; van den Heuvel-Eibrink, Marry M.; Tissing, Wim J. E.; Loonen, Jacqueline J.; Versluys, Birgitta; Bresters, Dorine; Kaspers, Gertjan J. L.; Lambalk, Cornelis B.; van Leeuwen, Flora E.; van Dulmen-den Broeder, Eline

    2012-01-01

    Background: Advances in childhood cancer treatment over the past decades have significantly improved survival, resulting in a rapidly growing group of survivors. However, both chemo- and radiotherapy may adversely affect reproductive function. This paper describes the design and encountered

  2. A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer: design and methodological challenges

    NARCIS (Netherlands)

    Overbeek, A.; van den Berg, M.H.; Kremer, L.C.; van den Heuvel-Eibrink, M.; Tissing, W.J.; Loonen, J.J.; Versluys, B.; Bresters, D.; Kaspers, G.J.L.; Lambalk, C.B.; van Leeuwen, F.E.; van Dulmen-den Broeder, E.

    2012-01-01

    Background: Advances in childhood cancer treatment over the past decades have significantly improved survival, resulting in a rapidly growing group of survivors. However, both chemo- and radiotherapy may adversely affect reproductive function. This paper describes the design and encountered

  3. Small signal audio design

    CERN Document Server

    Self, Douglas

    2014-01-01

    Learn to use inexpensive and readily available parts to obtain state-of-the-art performance in all the vital parameters of noise, distortion, crosstalk and so on. With ample coverage of preamplifiers and mixers and a new chapter on headphone amplifiers, this practical handbook provides an extensive repertoire of circuits that can be put together to make almost any type of audio system.A resource packed full of valuable information, with virtually every page revealing nuggets of specialized knowledge not found elsewhere. Essential points of theory that bear on practical performance are lucidly

  4. Theoretical basis, principles of design, and experimental study of the prototype of perfect AFCS transmitting signals without coding

    Science.gov (United States)

    Platonov, A.; Zaitsev, Ie.; Opalski, L. J.

    2017-08-01

    The paper presents an overview of design methodology and results of experiments with a Prototype of highly efficient optimal adaptive feedback communication systems (AFCS), transmitting low frequency analog signals without coding. The paper emphasizes the role of the forward transmitter saturation as the factor that blocked implementation of theoretical results of pioneer (1960-1970s) and later research on FCS. Deepened analysis of the role of statistical fitting condition in adequate formulation and solution of AFCS optimization task is given. Solution of the task - optimal transmission/reception algorithms is presented in the form useful for elaboration of the hardware/software Prototype. A notable particularity of the Prototype is absence of the encoding/decoding units, whose functions are realized by the adaptive pulse amplitude modulator (PAM) of the forward transmitter (FT) and estimating/controlling algorithm in the receiver of base station (BS). Experiments confirm that the Prototype transmits signals from FT to BS "perfectly": with the bit rate equal to the capacity of the system, and with limit energy [J/bit] and spectral [bps/Hz] efficiency. Another, not less important and confirmed experimentally, particularity of AFCS is its capability to adjust parameters of FT and BS to the characteristics of scenario of application and maintain the ideal regime of transmission including spectralenergy efficiency. AFCS adjustment can be made using BS estimates of mean square error (MSE). The concluding part of the paper contains discussion of the presented results, stressing capability of AFCS to solve problems appearing in development of dense wireless networks.

  5. Design of a Randomized Controlled Trial of a Web-Based Intervention to Reduce Cardiovascular Disease Risk Factors among Remote Reservation-Dwelling American Indian Adults with Type 2 Diabetes

    Science.gov (United States)

    Henderson, Jeffrey A.; Chubak, Jessica; O'Connell, Joan; Ramos, Maria C.; Jensen, Julie; Jobe, Jared B.

    2012-01-01

    We describe a randomized controlled trial, the Lakota Oyate Wicozani Pi Kte (LOWPK) trial, which was designed to determine whether a Web-based diabetes and nutritional intervention can improve risk factors related to cardiovascular disease (CVD) among a group of remote reservation-dwelling adult American Indian men and women with type 2 diabetes…

  6. Relevancies of multiple-interaction events and signal-to-noise ratio for Anger-logic based PET detector designs

    Science.gov (United States)

    Peng, Hao

    2015-10-01

    A fundamental challenge for PET block detector designs is to deploy finer crystal elements while limiting the number of readout channels. The standard Anger-logic scheme including light sharing (an 8 by 8 crystal array coupled to a 2×2 photodetector array with an optical diffuser, multiplexing ratio: 16:1) has been widely used to address such a challenge. Our work proposes a generalized model to study the impacts of two critical parameters on spatial resolution performance of a PET block detector: multiple interaction events and signal-to-noise ratio (SNR). The study consists of the following three parts: (1) studying light output profile and multiple interactions of 511 keV photons within crystal arrays of different crystal widths (from 4 mm down to 1 mm, constant height: 20 mm); (2) applying the Anger-logic positioning algorithm to investigate positioning/decoding uncertainties (i.e., "block effect") in terms of peak-to-valley ratio (PVR), with light sharing, multiple interactions and photodetector SNR taken into account; and (3) studying the dependency of spatial resolution on SNR in the context of modulation transfer function (MTF). The proposed model can be used to guide the development and evaluation of a standard Anger-logic based PET block detector including: (1) selecting/optimizing the configuration of crystal elements for a given photodetector SNR; and (2) predicting to what extent additional electronic multiplexing may be implemented to further reduce the number of readout channels.

  7. The design and development of signal-processing algorithms for an airborne x-band Doppler weather radar

    Science.gov (United States)

    Nicholson, Shaun R.

    1994-01-01

    Improved measurements of precipitation will aid our understanding of the role of latent heating on global circulations. Spaceborne meteorological sensors such as the planned precipitation radar and microwave radiometers on the Tropical Rainfall Measurement Mission (TRMM) provide for the first time a comprehensive means of making these global measurements. Pre-TRMM activities include development of precipitation algorithms using existing satellite data, computer simulations, and measurements from limited aircraft campaigns. Since the TRMM radar will be the first spaceborne precipitation radar, there is limited experience with such measurements, and only recently have airborne radars become available that can attempt to address the issue of the limitations of a spaceborne radar. There are many questions regarding how much attenuation occurs in various cloud types and the effect of cloud vertical motions on the estimation of precipitation rates. The EDOP program being developed by NASA GSFC will provide data useful for testing both rain-retrieval algorithms and the importance of vertical motions on the rain measurements. The purpose of this report is to describe the design and development of real-time embedded parallel algorithms used by EDOP to extract reflectivity and Doppler products (velocity, spectrum width, and signal-to-noise ratio) as the first step in the aforementioned goals.

  8. Fluorescence Regulation of Copper Nanoclusters via DNA Template Manipulation toward Design of a High Signal-to-Noise Ratio Biosensor.

    Science.gov (United States)

    Li, Junyao; Fu, Wenxin; Bao, Jianchun; Wang, Zhaoyin; Dai, Zhihui

    2018-02-28

    Because of bioaccumulation of food chain and disability of biodegradation, concentration of toxic mercury ions (Hg 2+ ) in the environment dramatically varies from picomolar to micromolar, indicating the importance of well-performed Hg 2+ analytical methods. Herein, reticular DNA is constructed by introducing thymine (T)-Hg 2+ -T nodes in poly(T) DNA, and copper nanoclusters (CuNCs) with aggregate morphology are prepared using this reticular DNA as a template. Intriguingly, the prepared CuNCs exhibit enhanced fluorescence. Meanwhile, the reticular DNA reveals evident resistance to enzyme digestion, further clarifying the fluorescence enhancement of CuNCs. Relying on the dual function of DNA manipulation, a high signal-to-noise ratio biosensor is designed. This analytical approach can quantify Hg 2+ in a very wide range (50 pM to 500 μM) with an ultralow detection limit (16 pM). Besides, depending on the specific interaction between Hg 2+ and reduced l-glutathione (GSH), this biosensor is able to evaluate the inhibition of GSH toward Hg 2+ . In addition, pollution of Hg 2+ in three lakes is tested using this method, and the obtained results are in accord with those from inductively coupled plasma mass spectrometry. In general, this work provides an alternative way to regulate the properties of DNA-templated nanomaterials and indicates the applicability of this way by fabricating an advanced biosensor.

  9. Design and Implementation of Controller for Boost DC-DC Converter Using PI-LPF Based on Small Signal Model

    Directory of Open Access Journals (Sweden)

    Slamet Kasbi

    2015-12-01

    Full Text Available Boost DC-DC converters are used in many renewable energy sources including photovoltaic and fuel cell. They are also used in Uninterrupted Power Supply, inverters, electric vehicles and robots. In this paper a boost converter was built and its controller was developed using proportional integral (PI action for current loop and low pass filter (LPF for voltage loop. The controller was derived analytically based on small signal model. Experiment results show that the boost controller functions well in regulating the output voltage under a variation of load. During the start up without any load it can elevate input voltage from 119.6V to output voltage of 241.6V. The developed controller can regulate the output voltage smoothly under load variation from no load to sudden load of 352W. When a large sudden load change happens from 0W to 1042W the output voltage experiences small drop before it is recovered to 241.6V. It can be concluded that the developed control system satisfies the design specification.

  10. An investigation of signal performance enhancements achieved through innovative pixel design across several generations of indirect detection, active matrix, flat-panel arrays

    International Nuclear Information System (INIS)

    Antonuk, Larry E.; Zhao Qihua; El-Mohri, Youcef; Du Hong; Wang Yi; Street, Robert A.; Ho, Jackson; Weisfield, Richard; Yao, William

    2009-01-01

    Active matrix flat-panel imager (AMFPI) technology is being employed for an increasing variety of imaging applications. An important element in the adoption of this technology has been significant ongoing improvements in optical signal collection achieved through innovations in indirect detection array pixel design. Such improvements have a particularly beneficial effect on performance in applications involving low exposures and/or high spatial frequencies, where detective quantum efficiency is strongly reduced due to the relatively high level of additive electronic noise compared to signal levels of AMFPI devices. In this article, an examination of various signal properties, as determined through measurements and calculations related to novel array designs, is reported in the context of the evolution of AMFPI pixel design. For these studies, dark, optical, and radiation signal measurements were performed on prototype imagers incorporating a variety of increasingly sophisticated array designs, with pixel pitches ranging from 75 to 127 μm. For each design, detailed measurements of fundamental pixel-level properties conducted under radiographic and fluoroscopic operating conditions are reported and the results are compared. A series of 127 μm pitch arrays employing discrete photodiodes culminated in a novel design providing an optical fill factor of ∼80% (thereby assuring improved x-ray sensitivity), and demonstrating low dark current, very low charge trapping and charge release, and a large range of linear signal response. In two of the designs having 75 and 90 μm pitches, a novel continuous photodiode structure was found to provide fill factors that approach the theoretical maximum of 100%. Both sets of novel designs achieved large fill factors by employing architectures in which some, or all of the photodiode structure was elevated above the plane of the pixel addressing transistor. Generally, enhancement of the fill factor in either discrete or continuous

  11. Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals.

    Science.gov (United States)

    Kobayashi, Hisataka; Longmire, Michelle R; Ogawa, Mikako; Choyke, Peter L

    2011-09-01

    In recent years, numerous in vivo molecular imaging probes have been developed. As a consequence, much has been published on the design and synthesis of molecular imaging probes focusing on each modality, each type of material, or each target disease. More recently, second generation molecular imaging probes with unique, multi-functional, or multiplexed characteristics have been designed. This critical review focuses on (i) molecular imaging using combinations of modalities and signals that employ the full range of the electromagnetic spectra, (ii) optimized chemical design of molecular imaging probes for in vivo kinetics based on biology and physiology across a range of physical sizes, (iii) practical examples of second generation molecular imaging probes designed to extract complementary data from targets using multiple modalities, color, and comprehensive signals (277 references). This journal is © The Royal Society of Chemistry 2011

  12. Small-Signal Modeling, Stability Analysis and Design Optimization of Single-Phase Delay-Based PLLs

    DEFF Research Database (Denmark)

    Golestan, Saeed; Guerrero, Josep M.; Vidal, Ana

    2016-01-01

    have been proposed, the simplest perhaps being the transfer delay based method. In the transfer delay based PLL (TD-PLL), the orthogonal signal is generated by delaying the original singlephase signal by T=4 (one-quarter of a period). The phase shift caused by the transfer delay block, however...

  13. Concept and design of a UAS-based platform for measurements of RF signal-in-space

    Science.gov (United States)

    Schrader, Thorsten; Bredemeyer, Jochen; Mihalachi, Marius; Rohde, Jan; Kleine-Ostmann, Thomas

    2016-09-01

    Field strength or signal-in-space (SIS) measurements have been performed by using manned helicopters, aircrafts or from ground level using extendable masts. With the availability of unmanned aerial systems (UAS) such as multicopters a new versatile platform for SIS measurements is deployable. Larger types show up to eight individually driven electric motors and controllers (therefore called octocopter). They provide the ability to fly along predefined traces, to hover at waypoints and to initiate other actions when those have been reached. They provide self-levelling and stabilisation and moreover, they may gear at a point of interest regardless of their actual position, e.g. during their flight around a tower. Their payload mainly depends on the platform size and allows integration of complex measurement equipment. Upgrading their navigation capabilities including state-of-the-art global navigation satellite system (GNSS) and ground station transmitter (real-time kinematic - RTK) enables precise localisation of the UAS. For operation in electromagnetic harsh environments a shielding can be considered and integrated into the concept. This paper describes concept and design of an octocopter and its instrumentation, along with applications in recent projects, in which we measure and validate terrestrial navigation systems applied in air traffic and the weather forecast services. Among those are instrumentation landing systems (ILS), VHF omnidirectional radio ranges (VOR), airport traffic and weather radars as well as military surveillance radars, and UHF wind profilers. Especially to investigate the possible interaction of VORs and radars with single wind turbines (WT) or wind power plants has become a major request of economy, military and politics. Here, UAS can be deployed to deliver measurement data investigating this interaction. Once developed and setup to a certain extent, UAS are easy and cost-efficient to operate. Nonetheless, due to their compact size, UAS

  14. Biosphere reserves: Attributes for success.

    Science.gov (United States)

    Van Cuong, Chu; Dart, Peter; Hockings, Marc

    2017-03-01

    Biosphere reserves established under the UNESCO Man and the Biosphere Program aim to harmonise biodiversity conservation and sustainable development. Concerns over the extent to which the reserve network was living up to this ideal led to the development of a new strategy in 1995 (the Seville Strategy) to enhance the operation of the network of reserves. An evaluation of effectiveness of management of the biosphere reserve network was called for as part of this strategy. Expert opinion was assembled through a Delphi Process to identify successful and less successful reserves and investigate common factors influencing success or failure. Ninety biosphere reserves including sixty successful and thirty less successful reserves in 42 countries across all five Man and the Biosphere Program regions were identified. Most successful sites are the post-Seville generation while the majority of unsuccessful sites are pre-Seville that are managed as national parks and have not been amended to conform to the characteristics that are meant to define a biosphere reserve. Stakeholder participation and collaboration, governance, finance and resources, management, and awareness and communication are the most influential factors in the success or failure of the biosphere reserves. For success, the biosphere reserve concept needs to be clearly understood and applied through landscape zoning. Designated reserves then need a management system with inclusive good governance, strong participation and collaboration, adequate finance and human resource allocation and stable and responsible management and implementation. All rather obvious but it is difficult to achieve without commitment to the biosphere reserve concept by the governance authorities. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. 75 FR 79286 - Designated Reserve Ratio

    Science.gov (United States)

    2010-12-20

    ... downside risks--such as high unemployment and weak real estate markets--that create a challenging operating... pressure as unemployment dampens business and consumer demand. Even as credit markets have begun to recover... appropriate. (3) That sharp swings in assessment rates for insured depository institutions should be prevented...

  16. Signal Processing

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    Signal processing techniques, extensively used nowadays to maximize the performance of audio and video equipment, have been a key part in the design of hardware and software for high energy physics detectors since pioneering applications in the UA1 experiment at CERN in 1979

  17. Pilot signal design via constrained optimization with application to delay-Doppler shift estimation in OFDM systems

    DEFF Research Database (Denmark)

    Jing, Lishuai; Pedersen, Troels; Fleury, Bernard Henri

    2013-01-01

    We address the problem of searching for the optimal pilot signal, i.e. pattern and signature, of an orthogonal frequency-division multiplexing (OFDM) system when the purpose is to estimate the delay and Doppler shift under the assumption of a single-path propagation channel. This problem is relev......We address the problem of searching for the optimal pilot signal, i.e. pattern and signature, of an orthogonal frequency-division multiplexing (OFDM) system when the purpose is to estimate the delay and Doppler shift under the assumption of a single-path propagation channel. This problem...

  18. Virtual instrumentation technique used in the nuclear digital signal processing system design: Energy and time measurement tests

    International Nuclear Information System (INIS)

    Pechousek, J.; Prochazka, R.; Prochazka, V.; Frydrych, J.

    2011-01-01

    In this report, computer-based digital signal processing system with a 200 MS s -1 sampling digitizer is presented. Virtual instrumentation technique is used to easily develop a system which provides spectroscopy measurements such as amplitude and time signal analysis, with the time-of-flight facility. Several test measurements were performed to determine the characteristics of a system. The presented system may find its application in the coincidence measurement since the system is usable for different types of detectors and sensitive to decay lifetimes from tens of nanoseconds to seconds.

  19. Cognitive reserve in aging.

    Science.gov (United States)

    Tucker, A M; Stern, Y

    2011-06-01

    Cognitive reserve explains why those with higher IQ, education, occupational attainment, or participation in leisure activities evidence less severe clinical or cognitive changes in the presence of age-related or Alzheimer's disease pathology. Specifically, the cognitive reserve hypothesis is that individual differences in how tasks are processed provide reserve against brain pathology. Cognitive reserve may allow for more flexible strategy usage, an ability thought to be captured by executive functions tasks. Additionally, cognitive reserve allows individuals greater neural efficiency, greater neural capacity, and the ability for compensation via the recruitment of additional brain regions. Taking cognitive reserve into account may allow for earlier detection and better characterization of age-related cognitive changes and Alzheimer's disease. Importantly, cognitive reserve is not fixed but continues to evolve across the lifespan. Thus, even late-stage interventions hold promise to boost cognitive reserve and thus reduce the prevalence of Alzheimer's disease and other age-related problems.

  20. Design and Development of Amplitude and phase measurement of RF signal with Digital I-Q Demodulator

    Science.gov (United States)

    Soni, Dipal; Rajnish, Kumar; Verma, Sriprakash; Patel, Hriday; Trivedi, Rajesh; Mukherjee, Aparajita

    2017-04-01

    ITER-India, working as a nodal agency from India for ITER project [1], is responsible to deliver one of the packages, called Ion Cyclotron Heating & Current Drive (ICH&CD) - Radio Frequency Power Sources (RFPS). RFPS is having two cascaded amplifier chains (10 kW, 130 kW & 1.5 MW) combined to get 2.5 MW RF power output. Directional couplers are inserted at the output of each stage to extract forward power and reflected power as samples for measurement of amplitude and phase. Using passive mixer, forward power and reflected power are down converted to 1MHz Intermediate frequency (IF). This IF signal is used as an input to the Digital IQ Demodulator (DIQDM). DIQDM is realized using National Instruments make PXI hardware & LabVIEW software tool. In this paper, Amplitude and Phase measurement of RF signal with DIQDM technique is described. Also test results with dummy signals and signal generated from low power RF systems is discussed here.

  1. Design of a candidate vibrational signal for mating disruption against the glassy-winged sharpshooter, Homalodisca Vitripennis

    Science.gov (United States)

    The glassy-winged sharpshooter (GWSS), Homalodisca vitripennis, is an important pest of grapevines due to its ability to transmit Xylella fastidiosa, the causal agent of Pierce’s disease. GWSS mating communication is based on vibrational signals; therefore, vibrational mating disruption could be an ...

  2. Design and development of an automated, portable and handheld tablet personal computer-based data acquisition system for monitoring electromyography signals during rehabilitation.

    Science.gov (United States)

    Ahamed, Nizam U; Sundaraj, Kenneth; Poo, Tarn S

    2013-03-01

    This article describes the design of a robust, inexpensive, easy-to-use, small, and portable online electromyography acquisition system for monitoring electromyography signals during rehabilitation. This single-channel (one-muscle) system was connected via the universal serial bus port to a programmable Windows operating system handheld tablet personal computer for storage and analysis of the data by the end user. The raw electromyography signals were amplified in order to convert them to an observable scale. The inherent noise of 50 Hz (Malaysia) from power lines electromagnetic interference was then eliminated using a single-hybrid IC notch filter. These signals were sampled by a signal processing module and converted into 24-bit digital data. An algorithm was developed and programmed to transmit the digital data to the computer, where it was reassembled and displayed in the computer using software. Finally, the following device was furnished with the graphical user interface to display the online muscle strength streaming signal in a handheld tablet personal computer. This battery-operated system was tested on the biceps brachii muscles of 20 healthy subjects, and the results were compared to those obtained with a commercial single-channel (one-muscle) electromyography acquisition system. The results obtained using the developed device when compared to those obtained from a commercially available physiological signal monitoring system for activities involving muscle contractions were found to be comparable (the comparison of various statistical parameters) between male and female subjects. In addition, the key advantage of this developed system over the conventional desktop personal computer-based acquisition systems is its portability due to the use of a tablet personal computer in which the results are accessible graphically as well as stored in text (comma-separated value) form.

  3. Manipulation of signaling thresholds in "engineered stem cell niches" identifies design criteria for pluripotent stem cell screens.

    Directory of Open Access Journals (Sweden)

    Raheem Peerani

    Full Text Available In vivo, stem cell fate is regulated by local microenvironmental parameters. Governing parameters in this stem cell niche include soluble factors, extra-cellular matrix, and cell-cell interactions. The complexity of this in vivo niche limits analyses into how individual niche parameters regulate stem cell fate. Herein we use mouse embryonic stem cells (mESC and micro-contact printing (microCP to investigate how niche size controls endogenous signaling thresholds. microCP is used to restrict colony diameter, separation, and degree of clustering. We show, for the first time, spatial control over the activation of the Janus kinase/signal transducer and activator of transcription pathway (Jak-Stat. The functional consequences of this niche-size-dependent signaling control are confirmed by demonstrating that direct and indirect transcriptional targets of Stat3, including members of the Jak-Stat pathway and pluripotency-associated genes, are regulated by colony size. Modeling results and empirical observations demonstrate that colonies less than 100 microm in diameter are too small to maximize endogenous Stat3 activation and that colonies separated by more than 400 microm can be considered independent from each other. These results define parameter boundaries for the use of ESCs in screening studies, demonstrate the importance of context in stem cell responsiveness to exogenous cues, and suggest that niche size is an important parameter in stem cell fate control.

  4. COGNITIVE RESERVE IN AGING

    Science.gov (United States)

    Tucker, Adrienne M.; Stern, Yaakov

    2011-01-01

    Cognitive reserve explains why those with higher IQ, education, occupational attainment, or participation in leisure activities evidence less severe clinical or cognitive changes in the presence of age-related or Alzheimer’s disease pathology. Specifically, the cognitive reserve hypothesis is that individual differences in how tasks are processed provide reserve against brain pathology. Cognitive reserve may allow for more flexible strategy usage, an ability thought to be captured by executive functions tasks. Additionally, cognitive reserve allows individuals greater neural efficiency, greater neural capacity, and the ability for compensation via the recruitment of additional brain regions. Taking cognitive reserve into account may allow for earlier detection and better characterization of age-related cognitive changes and Alzheimer’s disease. Importantly, cognitive reserve is not fixed but continues to evolve across the lifespan. Thus, even late-stage interventions hold promise to boost cognitive reserve and thus reduce the prevalence of Alzheimer’s disease and other age-related problems. PMID:21222591

  5. HYDROCARBONS RESERVES IN VENEZUELA

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Cruz, D.J.

    2007-07-01

    Venezuela is an important player in the energy world, because of its hydrocarbons reserves. The process for calculating oil and associated gas reserves is described bearing in mind that 90% of the gas reserves of Venezuela are associated to oil. Likewise, an analysis is made of the oil reserves figures from 1975 to 2003. Reference is also made to inconsistencies found by international experts and the explanations offered in this respect by the Ministry of Energy and Petroleum (MENPET) and Petroleos de Venezuela (PDVSA) regarding the changes that took place in the 1980s. In turn, Hubbert's Law is explained to determine peak production of conventional oil that a reservoir or field will reach, as well as its relationship with remaining reserves. Emphasis is placed on the interest of the United Nations on this topic. The reserves of associated gas are presented along with their relationship with the different crude oils that are produced and with injected gas, as well as with respect to the possible changes that would take place in the latter if oil reserves are revised. Some recommendations are submitted so that the MENPET starts preparing the pertinent policies ruling reserves. (auth)

  6. Ovarian reserve parameters

    DEFF Research Database (Denmark)

    Bentzen, J G; Forman, Julie Lyng; Pinborg, Anja

    2012-01-01

    2-5 of the menstrual cycle or during withdrawal bleeding, blood sampling and transvaginal sonography was performed. After adjusting for age, ovarian reserve parameters were lower among users than among non-users of hormonal contraception: serum AMH concentration by 29.8% (95% CI 19.9 to 38...... was observed between duration of hormonal-contraception use and ovarian reserve parameters. No dose-response relation was found between the dose of ethinyloestradiol and AMH or AFC. This study indicates that ovarian reserve markers are lower in women using sex steroids for contraception. Thus, AMH...... concentration and AFC may not retain their accuracy as predictors of ovarian reserve in women using hormonal contraception. Serum anti-Müllerian hormone (AMH) concentration is an indirect marker of the number of small follicles in the ovary and thereby the ovarian reserve. The AMH concentration is now widely...

  7. Demand as Frequency Controlled Reserve

    DEFF Research Database (Denmark)

    Xu, Zhao; Østergaard, Jacob; Togeby, Mikael

    2011-01-01

    Relying on generation side alone is deemed insufficient to fulfill the system balancing needs for future Danish power system, where a 50% wind penetration is outlined by the government for year 2025. This paper investigates using the electricity demand as frequency controlled reserve (DFR) as a new...... balancing measure, which has a high potential and can provide many advantages. Firstly, the background of the research is reviewed, including conventional power system reserves and the electricity demand side potentials. Subsequently, the control logics and corresponding design considerations for the DFR...

  8. An EM Simulation-Based Design Flow for Custom-Built MR Coils Incorporating Signal and Noise.

    Science.gov (United States)

    Horneff, Andreas; Eder, Michael; Hell, Erich; Ulrici, Johannes; Felder, Jorg; Rasche, Volker; Anders, Jens

    2018-02-01

    Developing custom-built MR coils is a cumbersome task, in which an a priori prediction of the coils' SNR performance, their sensitivity pattern, and their depth of penetration helps to greatly speed up the design process by reducing the required hardware manufacturing iterations. The simulation-based design flow presented in this paper takes the entire MR imaging process into account. That is, it includes all geometric and material properties of the coil and the phantom, the thermal noise as well as the target MR sequences. The proposed simulation-driven design flow is validated using a manufactured prototype coil, whose performance was optimized regarding its SNR performance, based on the presented design flow, by comparing the coil's measured performance against the simulated results. In these experiments, the mean and the standard deviation of the relative error between the simulated and measured coil sensitivity pattern were found to be and . Moreover, the peak deviation between the simulated and measured voxel SNR was found to be less than 4%, indicating that simulations are in good accordance with the measured results, validating the proposed software-based design approach.

  9. Skyline Reservation System

    Data.gov (United States)

    US Agency for International Development — Flight reservation application used for in-country flights by USAID and DoS staff in Afghanistan. The application is managed and maintained by the vendor and USAID...

  10. Investigation of coherent receiver designs in high-speed optical inter-satellite links using digital signal processing

    Science.gov (United States)

    Schaefer, S.; Gregory, M.; Rosenkranz, W.

    2017-09-01

    Due to higher data rates, better data security and unlicensed spectral usage optical inter-satellite links (OISL) offer an attractive alternative to conventional RF-communication. However, the very high transmission distances necessitate an optical receiver design enabling high receiver sensitivity which requires careful carrier synchronization and a quasi-coherent detection scheme.

  11. Design

    DEFF Research Database (Denmark)

    Volf, Mette

    This publication is unique in its demystification and operationalization of the complex and elusive nature of the design process. The publication portrays the designer’s daily work and the creative process, which the designer is a part of. Apart from displaying the designer’s work methods...... and design parameters, the publication shows examples from renowned Danish design firms. Through these examples the reader gets an insight into the designer’s reality....

  12. Realistic head model design and 3D brain imaging of NIRS signals using audio stimuli on preterm neonates for intra-ventricular hemorrhage diagnosis.

    Science.gov (United States)

    Fournier, Marc; Mahmoudzadeh, Mahdi; Kazemi, Kamran; Kongolo, Guy; Dehaene-Lambertz, Ghislaine; Grebe, Reinhard; Wallois, Fabrice

    2012-01-01

    In this paper we propose an auditory stimulation and near infra-red spectroscopy (NIRS) hemodynamic changes acquisition protocol for preterm neonates. This study is designed to assess the specific characteristics of neurovascular coupling to auditory stimuli in healthy and ill neonate brains. The method could lead to clinical application in intra-ventricular hemorrhage (IVH) diagnosis along with other techniques such as EEG. We propose a realistic head model creation with all useful head structures and brain tissues including the neonate fontanel for more accurate results from NIRS signals modeling. We also design a 3D imaging tool for dynamic mapping and analysis of brain activation onto the cortex surface. Results show significant differences in oxy-hemoglobin between healthy neonates and subjects with IVH.

  13. Demand as frequency controlled reserve

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Z.; Togeby, M.; OEstergaard, J.

    2008-09-15

    Using demand as frequency controlled reserve (DFR) is an emerging technology which allow demand to participate actively in maintaining the system operation without reducing the energy service delivered to the customer and without need of user interaction. The basic premise is that traditional frequency controlled reserves from power plants and interconnections with neighbouring systems can be costly, slow and not fulfil the need for future power grids with a high share of wind power and fewer central power plants, and an intention to perform flexible operation such as is landing. Electricity demands, on the other hand, have advantages as frequency reserve including fast activation speed, smooth linear activation, low expected costs, and well-dispersed in the distribution grid. The main challenge of DFR is new methods for monitoring the available capacity. This project has investigated the technology of using electricity demands for providing frequency reserve to power systems. Within the project the potential and economy of DFR compatible loads in Denmark has been investigated, control logic has been designed, power system impact has been investigated, potential business models has been evaluated and an implementation strategy has been suggested. The tasks and goals of the project have been successfully accomplished based on which the conclusion and future recommendation are made. This project has developed the DFR technology that enables electricity demands to autonomously disconnect or reconnect to the grid in response to system frequency variations. The developed DFR technology is proved to be a promising technology from several perspectives. Technically, using DFR is feasible to provide reserves and enhance power system frequency control, while fulfilling technical requirements such as linear activation (or reconnection) according to frequency (or time). Environmentally, the DFR technology is pollution free in contrast to traditional reserves from generation

  14. Handbook on loss reserving

    CERN Document Server

    Schmidt, Klaus; Schnaus, Anja

    2016-01-01

    This handbook presents the basic aspects of actuarial loss reserving. Besides the traditional methods, it also includes a description of more recent ones and a discussion of certain problems occurring in actuarial practice, like inflation, scarce data, large claims, slow loss development, the use of market statistics, the need for simulation techniques and the task of calculating best estimates and ranges of future losses. In property and casualty insurance the provisions for payment obligations from losses that have occurred but have not yet been settled usually constitute the largest item on the liabilities side of an insurer's balance sheet. For this reason, the determination and evaluation of these loss reserves is of considerable economic importance for every property and casualty insurer. Actuarial students, academics as well as practicing actuaries will benefit from this overview of the most important actuarial methods of loss reserving by developing an understanding of the underlying stochastic models...

  15. Lithium reserves and resources

    International Nuclear Information System (INIS)

    Evans, R.K.

    1978-01-01

    As a result of accelerating research efforts in the fields of secondary batteries and thermonuclear power generation, concern has been expressed in certain quarters regarding the availability, in sufficient quantities, of lithium. As part of a recent study by the National Research Council on behalf of the Energy Research and Development Administration, a subpanel was formed to consider the outlook for lithium. Principal areas of concern were reserves, resources and the 'surplus' available for energy applications after allowing for the growth in current lithium applications. Reserves and resources were categorized into four classes ranging from fully proved reserves to resources which are probably dependent upon the marketing of co-products to become economically attractive. Because of the proprietary nature of data on beneficiation and processing recoveries, the tonnages of available lithium are expressed in terms of plant feed. However, highly conservative assumptions have been made concerning mining recoveries and these go a considerable way to accounting for total losses. Western World reserves and resources of all classes are estimated at 10.6 million tonnes Li of which 3.5 million tonnes Li are located in the United States. Current United States capacity, virtually equivalent to Western World capacity, is 4700 tonnes Li and production in 1976 approximated to 3500 tonnes Li. Production for current applications is expected to grow to approx. 10,000 tonnes in year 2000 and 13,000 tonnes a decade later. The massive excess of reserves and resources over that necessary to support conventional requirements has limited the amount of justifiable exploration expenditures; on the last occasion, there was a a major increase in demand (by the USAEA) reserves and capacity were increased rapidly. There are no foreseeable reasons why this shouldn't happen again when the need is clear. (author)

  16. Rational design of DKK3 structure-based small peptides as antagonists of Wnt signaling pathway and in silico evaluation of their efficiency.

    Directory of Open Access Journals (Sweden)

    Mansour Poorebrahim

    Full Text Available Dysregulated Wnt signaling pathway is highly associated with the pathogenesis of several human cancers. Dickkopf proteins (DKKs are thought to inhibit Wnt signaling pathway through binding to lipoprotein receptor-related protein (LRP 5/6. In this study, based on the 3-dimensional (3D structure of DKK3 Cys-rich domain 2 (CRD2, we have designed and developed several peptide inhibitors of Wnt signaling pathway. Modeller 9.15 package was used to predict 3D structure of CRD2 based on the Homology modeling (HM protocol. After refinement and minimization with GalaxyRefine and NOMAD-REF servers, the quality of selected models was evaluated utilizing VADAR, SAVES and ProSA servers. Molecular docking studies as well as literature-based information revealed two distinct boxes located at CRD2 which are actively involved in the DKK3-LRP5/6 interaction. A peptide library was constructed conducting the backrub sequence tolerance scanning protocol in Rosetta3.5 according to the DKK3-LRP5/6 binding sites. Seven tolerated peptides were chosen and their binding affinity and stability were improved by some logical amino acid substitutions. Molecular dynamics (MD simulations of peptide-LRP5/6 complexes were carried out using GROMACS package. After evaluation of binding free energies, stability, electrostatic potential and some physicochemical properties utilizing computational approaches, three peptides (PEP-I1, PEP-I3 and PEP-II2 demonstrated desirable features. However, all seven improved peptides could sufficiently block the Wnt-binding site of LRP6 in silico. In conclusion, we have designed and improved several small peptides based on the LRP6-binding site of CRD2 of DKK3. These peptides are highly capable of binding to LRP6 in silico, and may prevent the formation of active Wnt-LRP6-Fz complex.

  17. SUIKERBOSRAND NATURE RESERVE

    African Journals Online (AJOL)

    Suikerbosrand Nature Reserve and fts educational facilities are run by the Transvaal. Division of. Nature Conservation. ... tion and the education facilities provided. The former are utilized mainly by the general public ... artist Paul Bosman (already reviewed in the EEASA newsletter). The co-founders of the Foundation are.

  18. Session 7: Reserve

    International Nuclear Information System (INIS)

    Bailey, R.; Crockford, G.

    2001-01-01

    The reserve session was devoted to some issues that came up through the workshop, which were grouped into three main areas: The Global Accelerator Network, Problems of stress and how to get organized to minimize them, What should an operations group be responsible for? This paper summarizes the discussions that took place. (author)

  19. School Shootings Stun Reservation

    Science.gov (United States)

    Borja, Rhea R.; Cavanagh, Sean

    2005-01-01

    This article deals with the impact brought by the school shootings at Red Lake Indian Reservation in Minnesota to the school community. A deeply troubled 16-year-old student shot and killed seven other people and himself at a high school. The nation's deadliest school attack since the 1999 slayings at Colorado's suburban Columbine High School took…

  20. SUIKERBOSRAND NATURE RESERVE

    African Journals Online (AJOL)

    reserve, the total length being 66 km with six overnight huts. There are also the BokmakiePie. Nature Troil. and the Cheetah Interpretive Troil. which can be used by day visitors. The former has two loops, one of 10 km and another of 17 km. The. Cheetah Troil. is much shorter and various points of interest are interpreted en ...

  1. Optimal Controller Design of a Wind Turbine with Doubly Fed Induction Generator for Small Signal Stability Enhancement

    DEFF Research Database (Denmark)

    Yang, Lihui; Yang, Guangya; Xu, Zhao

    2010-01-01

    Multi-objective optimal controller design of a doubly fed induction generator (DFIG) wind turbine system using Differential Evolution (DE) is presented in this chapter. A detailed mathematical model of DFIG wind turbine with a close loop vector control system is developed. Based on this, objectiv......-objective problem and the constraint with DE. Eigenvalue analysis and simulation are performed on the single machine infinite bus (SMIB) system to demonstrate the control performance of the system with the optimized controller parameters.......Multi-objective optimal controller design of a doubly fed induction generator (DFIG) wind turbine system using Differential Evolution (DE) is presented in this chapter. A detailed mathematical model of DFIG wind turbine with a close loop vector control system is developed. Based on this, objective...... functions, addressing the steady state stability and dynamic performance at different operating conditions are implemented to optimize the controller parameters of both the rotor and grid side converters. A superior ε-constraint method and method of adaptive penalties are applied to handle the multi...

  2. Optimal controller design of a doubly fed induction generator wind turbine system for small signal stability enhancement

    DEFF Research Database (Denmark)

    Yang, Lihui; Yang, Guang-Ya; Xu, Zhao

    2010-01-01

    Multi-objective optimal controller design of a doubly-fed induction generator (DFIG) wind turbine system using differential evolution (DE) is presented. A detailed mathematical model of DFIG wind turbine with a closed-loop vector control system is developed. Based on this, objective functions...... and the constraint with DE, respectively. Eigenvalue analysis and time-domain simulations are performed on a single machine infinite bus system as well as a nine-bus multi-machine system with two DFIG wind turbines to illustrate the control performance of the DFIG wind turbine with the optimised controller...... parameters. The electric energy productions of the studied DFIG wind turbine system with and without optimised controller parameters under turbulent wind speed are also demonstrated....

  3. The Strategic Petroleum Reserve

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    The Strategic Petroleum Reserve program was set into motion by the 1975 Energy Policy and Conservation Act (EPCA). By 1990, 590 million barrels of oil had been placed in storage. Salt domes along the Gulf Coast offered ideal storage. Both sweet'' and sour'' crude oil have been acquired using various purchase options. Drawdown, sale, and distribution of the oil would proceed according to guidelines set by EPCA in the event of a severe energy supply disruption. (SM)

  4. [Hypertrophy and coronary reserve].

    Science.gov (United States)

    Motz, W; Scheler, S

    2008-12-01

    Left ventricular hypertrophy represents the structural mechanism of adaptation of the left ventricle as the answer of a chronic pressure overload in arterial hypertension. Initially an increment in left ventricular wall thickness occurs. In this stadium of "concentric hypertrophy" LV systolic wall stress, LV ejection fraction and myocardial oxygen consumption per weight unit myocardium remain unchanged. In the further time course of disease LV dilatation will be present. In this phase of "excentric hypertrophy" LV systolic wall stress and myocardial oxygen consumption per weight unit myocardium rise and LV ejection fraction decreases. Patients with arterial hypertension frequently complain of angina pectoris. Angina pectoris and the positive exercise tolerance test or the positive myocardial scintigraphy are the consequence of the impaired coronary flow reserve. The coronary flow reserve is diminished due to structural and functional changes of the coronary circulation. ACE-inhibitors and AT1-receptor blockers cause a significant improvement of coronary flow reserve and regression of both left ventricular hypertrophy and myocardial fibrosis.

  5. The newest digital signal processing

    International Nuclear Information System (INIS)

    Lee, Chae Uk

    2002-08-01

    This book deal with the newest digital signal processing, which contains introduction on conception of digital signal processing, constitution and purpose, signal and system such as signal, continuos signal, discrete signal and discrete system, I/O expression on impress response, convolution, mutual connection of system and frequency character,z transform of definition, range, application of z transform and relationship with laplace transform, Discrete fourier, Fast fourier transform on IDFT algorithm and FFT application, foundation of digital filter of notion, expression, types, frequency characteristic of digital filter and design order of filter, Design order of filter, Design of FIR digital filter, Design of IIR digital filter, Adaptive signal processing, Audio signal processing, video signal processing and application of digital signal processing.

  6. Design and implementation of an integrated architecture for massive parallel data treatment of analogue signals supplied by silicon detectors of very high spatial resolution

    International Nuclear Information System (INIS)

    Michel, J.

    1993-02-01

    This doctorate thesis studies an integrated architecture designed to a parallel massive treatment of analogue signals supplied by silicon detectors of very high spatial resolution. The first chapter is an introduction presenting the general outline and the triggering conditions of the spectrometer. Chapter two describes the operational structure of a microvertex detector made of Si micro-plates associated to the measuring chains. Information preconditioning is related to the pre-amplification stage, to the pile-up effects and to the reduction in the time characteristic due to the high counting rates. The chapter three describes the architecture of the analogue delay buffer, makes an analysis of the intrinsic noise and presents the operational testings and input/output control operations. The fourth chapter is devoted to the description of the analogue pulse shape processor and gives also the testings and the corresponding measurements on the circuit. Finally, the chapter five deals with the simplest modeling of the entire conditioning chain. Also, the testings and measuring procedures are here discussed. In conclusion the author presents some prospects for improving the signal-to-noise ratio by summation of the de-convoluted micro-paths. 78 refs., 78 figs., 1 annexe

  7. Fractional Reserve Banking

    OpenAIRE

    Andreasen, Niels; Bjerregaard, Mads; Lund, Jonas; Olsen, Ove Bitsch; Rasmussen, Andreas Dalgas

    2012-01-01

    Projektet er bygget op omkring kritisk realisme, som er det gennemgående videnskabelige fundament til undersøgelsen af hvilke strukturelle grunde der er til finansiel ustabilitet i Danmark. Projektet går i dybden med Fractional Reserve Banking og incitamentsstrukturen i banksystemet. Vi bevæger os både på det makro- og mikroøkonomiske niveau i analysen. På makro niveau bruger vi den østrigske skole om konjunktur teori (The Positive Theory of the Cycle). På mikro niveau arbejder vi med princip...

  8. Design

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Pettiway, Keon

    2017-01-01

    by designers, planners, etc. (staging from above) and mobile subjects (staging from below). A research agenda for studying situated practices of mobility and mobilities design is outlined in three directions: foci of studies, methods and approaches, and epistemologies and frames of thinking. Jensen begins......In this chapter, Ole B. Jensen takes a situational approach to mobilities to examine how ordinary life activities are structured by technology and design. Using “staging mobilities” as a theoretical approach, Jensen considers mobilities as overlapping, actions, interactions and decisions...... with a brief description of how movement is studied within social sciences after the “mobilities turn” versus the idea of physical movement in transport geography and engineering. He then explains how “mobilities design” was derived from connections between traffic and architecture. Jensen concludes...

  9. Design

    DEFF Research Database (Denmark)

    Volf, Mette

    Design - proces & metode iBog®  er enestående i sit fokus på afmystificering og operationalisering af designprocessens flygtige og komplekse karakter. Udgivelsen går bag om designerens daglige arbejde og giver et indblik i den kreative skabelsesproces, som designeren er en del af. Udover et bredt...... indblik i designerens arbejdsmetoder og designparametre giver Design - proces & metode en række eksempler fra anerkendte designvirksomheder, der gør det muligt at komme helt tæt på designerens virkelighed....

  10. Design

    Science.gov (United States)

    Buchanan, Richard; Cross, Nigel; Durling, David; Nelson, Harold; Owen, Charles; Valtonen, Anna; Boling, Elizabeth; Gibbons, Andrew; Visscher-Voerman, Irene

    2013-01-01

    Scholars representing the field of design were asked to identify what they considered to be the most exciting and imaginative work currently being done in their field, as well as how that work might change our understanding. The scholars included Richard Buchanan, Nigel Cross, David Durling, Harold Nelson, Charles Owen, and Anna Valtonen. Scholars…

  11. Design

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Pettiway, Keon

    2017-01-01

    In this chapter, Ole B. Jensen takes a situational approach to mobilities to examine how ordinary life activities are structured by technology and design. Using “staging mobilities” as a theoretical approach, Jensen considers mobilities as overlapping, actions, interactions and decisions by desig......In this chapter, Ole B. Jensen takes a situational approach to mobilities to examine how ordinary life activities are structured by technology and design. Using “staging mobilities” as a theoretical approach, Jensen considers mobilities as overlapping, actions, interactions and decisions...... by designers, planners, etc. (staging from above) and mobile subjects (staging from below). A research agenda for studying situated practices of mobility and mobilities design is outlined in three directions: foci of studies, methods and approaches, and epistemologies and frames of thinking. Jensen begins...... with a brief description of how movement is studied within social sciences after the “mobilities turn” versus the idea of physical movement in transport geography and engineering. He then explains how “mobilities design” was derived from connections between traffic and architecture. Jensen concludes...

  12. A Policy Analysis of Reserve Retirement Reform

    Science.gov (United States)

    2013-01-01

    adapted their manning requirements to this retention. Perhaps tasks and jobs have been designed to accommodate the reten - tion profile produced by the...a reward for a long career of service, a benefit to help transition to the civilian economy, and a means of securing the reten - tion of career...to determine their likely effect on active reten - tion, reserve affiliation after leaving an active component, reserve retention, and reserve

  13. 14 CFR 33.13 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false [Reserved] 33.13 Section 33.13 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; General § 33.13 [Reserved] ...

  14. 14 CFR 35.13 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false [Reserved] 35.13 Section 35.13 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: PROPELLERS Design and Construction § 35.13 [Reserved] ...

  15. 14 CFR 35.11 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false [Reserved] 35.11 Section 35.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: PROPELLERS Design and Construction § 35.11 [Reserved] ...

  16. Rezultati obrade signala u projektovanim blokovima prijemnika softverskog radara / Results of the signal processing in designed receiver blocks of software radar

    Directory of Open Access Journals (Sweden)

    Dejan S. Ivković

    2008-04-01

    Full Text Available U radu su prikazani rezultati obrade signala u ranije projektovanim softverskim modulima radarskog prijemnika. Prvo su navedeni rezultati merenja realnog klatera bez prisustva ciljeva u vazdušnom prostoru, zatim rezultati detekcije simuliranih ciljeva u prisustvu realnog klatera i, na kraju, rezultati detekcije tri realna cilja u vazduhu. Svi parametri pri merenju klatera i detekcije simuliranih i realnih ciljeva prikazani su tabelarno, a rezultati grafički. Na osnovu analize prikazanih rezultata može se zaključiti da projektovani softverski moduli radarskog prijemnika dobro emuliraju rad postojećih hardverskih blokova realnog radara. / This paper presents the results of signal processing in previously designed software modules of radar receivers. The measurement procedure is described briefly. The results of measuring real clutter without aerial targets are followed by the results of detecting simulated targets in the presence of real clutter. Finally, the results of the detection of three real targets in the air are presented. All parameters of the clutter measurement and the detection of targets, both simulated and real, are given in tables while the results are showed graphically. On the basis of the analysis of the obtained results, it can be concluded that the designed software modules of the radar receiver successfully emulate the operation of existing hardware blocks of real radars.

  17. Are uranium reserves adequate?

    International Nuclear Information System (INIS)

    Anon.

    2006-01-01

    Against a backdrop of growing concerns about global warming and geopolitical pressures on fossil energies, especially natural gas and oil, interest in nuclear power has revived considerably. Conscious of its addiction to oil and reeling from a series of gigantic blackouts, the United States, in the words of its president, must 'aggressively move forward with the construction of nuclear power plants'. Some European countries have approved new power plant construction (Finland and France), while the more reserved ones (Belgium, Germany and Sweden) have begun to show a change in attitude. Asia, meanwhile, is host to the planet's largest number of potential nuclear construction projects in this first half of the 21. century. All these signs point to a sharp rise in uranium consumption, the basic fuel for these plants. But are there enough resources to support a nuclear revival on a planetary scale? The publication of the Red Book on uranium in late May 2006 was an opportunity for Thierry Dujardin, Deputy Director of Science and Development at the OECD's Nuclear Energy Agency, to take stock of resources. He gives his opinion in this paper

  18. Retrograde signaling

    DEFF Research Database (Denmark)

    Kleine, Tatjana; Leister, Dario Michael

    2016-01-01

    The term retrograde signaling refers to the fact that chloroplasts and mitochondria utilize specific signaling molecules to convey information on their developmental and physiological states to the nucleus and modulate the expression of nuclear genes accordingly. Signals emanating from plastids...... of retrograde signaling has since been extended and revised. Elements of several 'operational' signaling circuits have come to light, including metabolites, signaling cascades in the cytosol and transcription factors. Here, we review recent advances in the identification and characterization of retrograde...

  19. SignalR blueprints

    CERN Document Server

    Ingebrigtsen, Einar

    2015-01-01

    This book is designed for software developers, primarily those with knowledge of C#, .NET, and JavaScript. Good knowledge and understanding of SignalR is assumed to allow efficient programming of core elements and applications in SignalR.

  20. cAMP signaling in subcellular compartments.

    Science.gov (United States)

    Lefkimmiatis, Konstantinos; Zaccolo, Manuela

    2014-09-01

    In the complex microcosm of a cell, information security and its faithful transmission are critical for maintaining internal stability. To achieve a coordinated response of all its parts to any stimulus the cell must protect the information received from potentially confounding signals. Physical segregation of the information transmission chain ensures that only the entities able to perform the encoded task have access to the relevant information. The cAMP intracellular signaling pathway is an important system for signal transmission responsible for the ancestral 'flight or fight' response and involved in the control of critical functions including frequency and strength of heart contraction, energy metabolism and gene transcription. It is becoming increasingly apparent that the cAMP signaling pathway uses compartmentalization as a strategy for coordinating the large number of key cellular functions under its control. Spatial confinement allows the formation of cAMP signaling "hot spots" at discrete subcellular domains in response to specific stimuli, bringing the information in proximity to the relevant effectors and their recipients, thus achieving specificity of action. In this report we discuss how the different constituents of the cAMP pathway are targeted and participate in the formation of cAMP compartmentalized signaling events. We illustrate a few examples of localized cAMP signaling, with a particular focus on the nucleus, the sarcoplasmic reticulum and the mitochondria. Finally, we discuss the therapeutic potential of interventions designed to perturb specific cAMP cascades locally. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. Strategic Petroleum Reserve annual/quarterly report

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-16

    During 1992 the Department continued planning activities for the expansion of the Strategic Petroleum Reserve to one billion barrels. A draft Environmental Impact Statement for the five candidate sites was completed in October 1992, and a series of public hearings was held during December 1992. Conceptual design engineering activities, life cycle cost estimates and geotechnical studies to support the technical requirements for an Strategic Petroleum Reserve Plan Amendment were essentially completed in December 1992. At the end of 1992, the Strategic Petroleum Reserve crude oil inventory was 574.7 million barrels and an additional 1.7 million barrels was in transit to the Reserve. During 1992 approximately 6.2 million barrels of crude oil were acquired for the Reserve. A Department of Energy Tiger Team Environmental, Safety and Health (ES&H) Assessment was conducted at the Strategic Petroleum Reserve from March 9 through April 10, 1992. In general, the Tiger Team found that Strategic Petroleum Reserve activities do not pose undue environmental, safety or health risks. The Strategic Petroleum Reserve`s Final Corrective Action Plan, prepared in response to the Tiger Team assessment, was submitted for Department approval in December 1992. On November 18, 1992, the Assistant Secretary for Fossil Energy selected DynMcDennott Petroleum Operations Company to provide management and operating services for the Strategic Petroleum Reserve for a period of 5 years commencing April 1, 1993. DynMcDermott will succeed Boeing Petroleum Services, Inc.

  2. Reserve selection using nonlinear species distribution models.

    Science.gov (United States)

    Moilanen, Atte

    2005-06-01

    Reserve design is concerned with optimal selection of sites for new conservation areas. Spatial reserve design explicitly considers the spatial pattern of the proposed reserve network and the effects of that pattern on reserve cost and/or ability to maintain species there. The vast majority of reserve selection formulations have assumed a linear problem structure, which effectively means that the biological value of a potential reserve site does not depend on the pattern of selected cells. However, spatial population dynamics and autocorrelation cause the biological values of neighboring sites to be interdependent. Habitat degradation may have indirect negative effects on biodiversity in areas neighboring the degraded site as a result of, for example, negative edge effects or lower permeability for animal movement. In this study, I present a formulation and a spatial optimization algorithm for nonlinear reserve selection problems in grid-based landscapes that accounts for interdependent site values. The method is demonstrated using habitat maps and nonlinear habitat models for threatened birds in the Netherlands, and it is shown that near-optimal solutions are found for regions consisting of up to hundreds of thousands grid cells, a landscape size much larger than those commonly attempted even with linear reserve selection formulations.

  3. Modified TEM cell design exposure system for in vitro exposure of cultured human astrocytes to 900 MHz GSM mobile phone type signals

    International Nuclear Information System (INIS)

    McKenzie, R.J.; McIntosh, R.L.; Iskra, S.; Carratelli, A.

    2002-01-01

    Full text: A key to the rigour of any experiment seeking to investigate possible effects on living systems of the electromagnetic energy (EME) from mobile phones is to ensure that the exposures used are accurately known and reflect the actual exposures. To achieve well controlled and characterised radiofrequency (RF) exposures is not trivial, and has been a concern in many previous studies. At St Vincent's Hospital Centre for Immunology (CFI), an in vitro study is being performed of possible gene expression changes in cultured human astrocytes exposed to GSM mobile phone type signals. In order to provide rigorous RF dosimetry for the study, Telstra Research Laboratories (TRL) has developed a modified transverse electromagnetic (TEM) cell exposure system. This paper will describe salient aspects of the design and development of the system used at CFI. In the experimental design proposed by CFI, live human astrocyte cells are exposed in standard Falcon TM 25 cm 3 plastic culture flasks while incubated in a CO 2 atmosphere at 37 deg C. The cells typically exist as a very thin monolayer (microns) adhered to the bottom of the flask under a layer of several millimetres of nutrient media. This particular arrangement presents a number of challenges for the design of an appropriate RF exposure system. Many RF exposure systems rely on measurements of average absorption within the target material to determine the specific absorption rate (SAR) in the sample. The actual SAR at any given point in the exposed volume may differ markedly from this average value, and typically varies quadratically with height (h) within the sample, where h is taken to be in the direction of the incident electric (E) field. This variance may be tolerable where the cells are distributed in solution throughout the volume, but this is not the case in this instance. Alternatively, keeping the sample very thin can reduce the variance. However, this limits the efficiency of the system, so that high input

  4. Fractional Reserve in Banking System

    OpenAIRE

    Valkonen, Maria

    2016-01-01

    This thesis is aimed to provide understanding of the role of the fractional reserve in the mod-ern banking system worldwide and particularly in Finland. The fractional reserve banking is used worldwide, but the benefits of this system are very disputable. On the one hand, experts say that the fractional reserve is a necessary instrument for the normal business and profit making. On the other hand, sceptics openly criticize the fractional reserve system and blame it for fiat money (money n...

  5. PAPR reduction based on tone reservation scheme for DCO-OFDM indoor visible light communications.

    Science.gov (United States)

    Bai, Jurong; Li, Yong; Yi, Yang; Cheng, Wei; Du, Huimin

    2017-10-02

    High peak-to-average power ratio (PAPR) leads to out-of-band power and in-band distortion in the direct current-biased optical orthogonal frequency division multiplexing (DCO-OFDM) systems. In order to effectively reduce the PAPR with faster convergence and lower complexity, this paper proposes a tone reservation based scheme, which is the combination of the signal-to-clipping noise ratio (SCR) procedure and the least squares approximation (LSA) procedure. In the proposed scheme, the transmitter of the DCO-OFDM indoor visible light communication (VLC) system is designed to transform the PAPR reduced signal into real-valued positive OFDM signal without doubling the transmission bandwidth. Moreover, the communication distance and the light emitting diode (LED) irradiance angle are taking into consideration in the evaluation of the system bit error rate (BER). The PAPR reduction efficiency of the proposed scheme is remarkable for DCO-OFDM indoor VLC systems.

  6. Technical evaluation of the electrical, instrumentation, and control design aspects of the override of containment purge valve isolation and other engineered safety feature signals for the Fort Calhoun Nuclear Power Plant

    International Nuclear Information System (INIS)

    Hackett, D.B.

    1980-01-01

    This report documents the technical evaluation of the electrical, instrumentation, and control design aspects of the override of containment purge valve isolation and other engineered safety feature signals for the Fort Calhoun nuclear power plant. The review criteria are based on IEEE Std-279-1971 requirements for the safety signals to all purge and ventilation isolation valves. This report is supplied as part of the Selected Electrical, Instrumentation, and Control Systems Issues Program being conducted for the US Nuclear Regulatory Commission by Lawrence Livermore Laboratory

  7. Performance evaluation of a new signal processing system design to improve CANDU SDS1 trip response during large break LOCA events

    International Nuclear Information System (INIS)

    Xia, Lingzhi; Gabbar, Hossam A.; Isham, Manir U.; Ponomarev, Vladimir

    2016-01-01

    Performance of a recently developed signal processing system for CANDU (Canada Deuterium Uraniu) reactor shutdown system 1 (SDS1) is evaluated in this paper. The evaluation is carried out in MATLAB/Simulink software environment as well as with an existing power measurement and signal processing system. The new signal processing algorithm is obtained based on the synthesis of several first order low pass filters with different delayed time constants. Throughout this paper, a special attention has been paid to compare the new signal processing system with the existing one. The dynamic behavior of the new signal processing system in the practical large loss of coolant accidents (LLOCA) events has also been examined. Simulation results show that during the LLOCA event, the reactor trip time, as well as the peak power, is decreased remarkably. Through the simulation studies, it has convincingly demonstrated that the new signal processing system has significant advantages over the existing system in terms of the improved trip response and accommodation of the spurious trip immunity. This advantage will significantly enhance the safety margin, or will bring economical benefits to nuclear power plants. (author)

  8. Multiscale Signal Analysis and Modeling

    CERN Document Server

    Zayed, Ahmed

    2013-01-01

    Multiscale Signal Analysis and Modeling presents recent advances in multiscale analysis and modeling using wavelets and other systems. This book also presents applications in digital signal processing using sampling theory and techniques from various function spaces, filter design, feature extraction and classification, signal and image representation/transmission, coding, nonparametric statistical signal processing, and statistical learning theory. This book also: Discusses recently developed signal modeling techniques, such as the multiscale method for complex time series modeling, multiscale positive density estimations, Bayesian Shrinkage Strategies, and algorithms for data adaptive statistics Introduces new sampling algorithms for multidimensional signal processing Provides comprehensive coverage of wavelets with presentations on waveform design and modeling, wavelet analysis of ECG signals and wavelet filters Reviews features extraction and classification algorithms for multiscale signal and image proce...

  9. VLSI design

    CERN Document Server

    Chandrasetty, Vikram Arkalgud

    2011-01-01

    This book provides insight into the practical design of VLSI circuits. It is aimed at novice VLSI designers and other enthusiasts who would like to understand VLSI design flows. Coverage includes key concepts in CMOS digital design, design of DSP and communication blocks on FPGAs, ASIC front end and physical design, and analog and mixed signal design. The approach is designed to focus on practical implementation of key elements of the VLSI design process, in order to make the topic accessible to novices. The design concepts are demonstrated using software from Mathworks, Xilinx, Mentor Graphic

  10. Foundations of signal processing

    CERN Document Server

    Vetterli, Martin; Goyal, Vivek K

    2014-01-01

    This comprehensive and engaging textbook introduces the basic principles and techniques of signal processing, from the fundamental ideas of signals and systems theory to real-world applications. Students are introduced to the powerful foundations of modern signal processing, including the basic geometry of Hilbert space, the mathematics of Fourier transforms, and essentials of sampling, interpolation, approximation and compression. The authors discuss real-world issues and hurdles to using these tools, and ways of adapting them to overcome problems of finiteness and localisation, the limitations of uncertainty and computational costs. Standard engineering notation is used throughout, making mathematical examples easy for students to follow, understand and apply. It includes over 150 homework problems and over 180 worked examples, specifically designed to test and expand students' understanding of the fundamentals of signal processing, and is accompanied by extensive online materials designed to aid learning, ...

  11. Computerized reserves assessment improves colliery planning. [Poland

    Energy Technology Data Exchange (ETDEWEB)

    Pozor, L.; Wrobel, R.

    1984-01-01

    The authors describe systems developed in Poland for the computerised assessment of coal reserves. The Zasoby system calculates coal reserves and evaluates selected natural properties of seams within the boundaries of an arbitrary mining property, based entirely on exploratory borehole data. The IOS-10 system is based on the Polish data bank for bituminous coal deposits. It is not suitable for use in mine design procedures, but is widely used for the statistical recording of reserves in areas currently being worked. The major part of the paper is devoted to a description of the Geo-3 system, used for the computation of reserves in prospective areas from borehole data, as well as in active mining areas or partially worked-out deposits. The computation method is explained and examples of the results obtained are given.

  12. Biomedical signal and image processing

    CERN Document Server

    Najarian, Kayvan

    2012-01-01

    INTRODUCTION TO DIGITAL SIGNAL AND IMAGE PROCESSINGSignals and Biomedical Signal ProcessingIntroduction and OverviewWhat is a ""Signal""?Analog, Discrete, and Digital SignalsProcessing and Transformation of SignalsSignal Processing for Feature ExtractionSome Characteristics of Digital ImagesSummaryProblemsFourier TransformIntroduction and OverviewOne-Dimensional Continuous Fourier TransformSampling and NYQUIST RateOne-Dimensional Discrete Fourier TransformTwo-Dimensional Discrete Fourier TransformFilter DesignSummaryProblemsImage Filtering, Enhancement, and RestorationIntroduction and Overview

  13. Molecular and Cellular Signaling

    CERN Document Server

    Beckerman, Martin

    2005-01-01

    A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases ...

  14. Adaptive signal processor

    Energy Technology Data Exchange (ETDEWEB)

    Walz, H.V.

    1980-07-01

    An experimental, general purpose adaptive signal processor system has been developed, utilizing a quantized (clipped) version of the Widrow-Hoff least-mean-square adaptive algorithm developed by Moschner. The system accommodates 64 adaptive weight channels with 8-bit resolution for each weight. Internal weight update arithmetic is performed with 16-bit resolution, and the system error signal is measured with 12-bit resolution. An adapt cycle of adjusting all 64 weight channels is accomplished in 8 ..mu..sec. Hardware of the signal processor utilizes primarily Schottky-TTL type integrated circuits. A prototype system with 24 weight channels has been constructed and tested. This report presents details of the system design and describes basic experiments performed with the prototype signal processor. Finally some system configurations and applications for this adaptive signal processor are discussed.

  15. Adaptive signal processor

    International Nuclear Information System (INIS)

    Walz, H.V.

    1980-07-01

    An experimental, general purpose adaptive signal processor system has been developed, utilizing a quantized (clipped) version of the Widrow-Hoff least-mean-square adaptive algorithm developed by Moschner. The system accommodates 64 adaptive weight channels with 8-bit resolution for each weight. Internal weight update arithmetic is performed with 16-bit resolution, and the system error signal is measured with 12-bit resolution. An adapt cycle of adjusting all 64 weight channels is accomplished in 8 μsec. Hardware of the signal processor utilizes primarily Schottky-TTL type integrated circuits. A prototype system with 24 weight channels has been constructed and tested. This report presents details of the system design and describes basic experiments performed with the prototype signal processor. Finally some system configurations and applications for this adaptive signal processor are discussed

  16. Nuclear, uranium, reserves, sustainability, independence; Nucleaire, Uranium, reserves, durabilite, independance

    Energy Technology Data Exchange (ETDEWEB)

    Acket, C

    2007-06-15

    In order to evaluate the energy independence concerning the nuclear energy, the author takes the state of the art about the uranium. He details the fuel needs, the reserves on the base of the today available techniques, the reserves on the base of the future techniques and concludes positively on the energy independence for the nuclear. (A.L.B.)

  17. Fundamentals of statistical signal processing

    CERN Document Server

    Kay, Steven M

    1993-01-01

    A unified presentation of parameter estimation for those involved in the design and implementation of statistical signal processing algorithms. Covers important approaches to obtaining an optimal estimator and analyzing its performance; and includes numerous examples as well as applications to real- world problems. MARKETS: For practicing engineers and scientists who design and analyze signal processing systems, i.e., to extract information from noisy signals — radar engineer, sonar engineer, geophysicist, oceanographer, biomedical engineer, communications engineer, economist, statistician, physicist, etc.

  18. Signal detection

    International Nuclear Information System (INIS)

    Tholomier, M.

    1985-01-01

    In a scanning electron microscope, whatever is the measured signal, the same set is found: incident beam, sample, signal detection, signal amplification. The resulting signal is used to control the spot luminosity with the observer cathodoscope. This is synchronized with the beam scanning on the sample; on the cathodoscope, the image in secondary electrons, backscattered electrons,... of the sample surface is reconstituted. The best compromise must be found between a register time low enough to remove eventual variations (under the incident beam) of the nature of the observed phenomenon, and a good spatial resolution of the image and a signal-to-noise ratio high enough. The noise is one of the basic limitations of the scanning electron microscope performance. The whose measurement line must be optimized to reduce it [fr

  19. Youth Problems on Indian Reservations.

    Science.gov (United States)

    Underhill, Ruth M., Ed.

    Juvenile delinquency was identified as the major problem affecting youth on Indian reservations. Causes for delinquency which were discussed included culture conflict, expectation of failure, unemployment, failure of homes and parents, discrimination, inadequate education, off-reservation schools, and alcoholism. Needs identified by tribal leaders…

  20. Can Creativity Predict Cognitive Reserve?

    Science.gov (United States)

    Palmiero, Massimiliano; Di Giacomo, Dina; Passafiume, Domenico

    2016-01-01

    Cognitive reserve relies on the ability to effectively cope with aging and brain damage by using alternate processes to approach tasks when standard approaches are no longer available. In this study, the issue if creativity can predict cognitive reserve has been explored. Forty participants (mean age: 61 years) filled out: the Cognitive Reserve…

  1. Disaggregating reserve-to-production ratios: An algorithm for United States oil and gas reserve development

    Science.gov (United States)

    Williams, Charles William

    Reserve-to-production ratios for oil and gas development are utilized by oil and gas producing states to monitor oil and gas reserve and production dynamics. These ratios are used to determine production levels for the manipulation of oil and gas prices while maintaining adequate reserves for future development. These aggregate reserve-to-production ratios do not provide information concerning development cost and the best time necessary to develop newly discovered reserves. Oil and gas reserves are a semi-finished inventory because development of the reserves must take place in order to implement production. These reserves are considered semi-finished in that they are not counted unless it is economically profitable to produce them. The development of these reserves is encouraged by profit maximization economic variables which must consider the legal, political, and geological aspects of a project. This development is comprised of a myriad of incremental operational decisions, each of which influences profit maximization. The primary purpose of this study was to provide a model for characterizing a single product multi-period inventory/production optimization problem from an unconstrained quantity of raw material which was produced and stored as inventory reserve. This optimization was determined by evaluating dynamic changes in new additions to reserves and the subsequent depletion of these reserves with the maximization of production. A secondary purpose was to determine an equation for exponential depletion of proved reserves which presented a more comprehensive representation of reserve-to-production ratio values than an inadequate and frequently used aggregate historical method. The final purpose of this study was to determine the most accurate delay time for a proved reserve to achieve maximum production. This calculated time provided a measure of the discounted cost and calculation of net present value for developing new reserves. This study concluded that

  2. Design of a ×4 subharmonic sub-millimeter wave diode mixer, based on an analytic expression for small-signal conversion admittance parameters

    DEFF Research Database (Denmark)

    Michaelsen, Rasmus Schandorph; Johansen, Tom Keinicke; Krozer, Viktor

    2013-01-01

    Instead of using frequency multipliers before a fundamental mixer, subharmonic mixers can be used. In order to develop novel subharmonic mixer architectures it is necessary to know the exact signal phase at the nonlinear element. The purpose of this paper is to generalize the description of the s...

  3. Phosphoinositide signaling.

    Science.gov (United States)

    Boss, Wendy F; Im, Yang Ju

    2012-01-01

    "All things flow and change…even in the stillest matter there is unseen flux and movement." Attributed to Heraclitus (530-470 BC), from The Story of Philosophy by Will Durant. Heraclitus, a Greek philosopher, was thinking on a much larger scale than molecular signaling; however, his visionary comments are an important reminder for those studying signaling today. Even in unstimulated cells, signaling pathways are in constant metabolic flux and provide basal signals that travel throughout the organism. In addition, negatively charged phospholipids, such as the polyphosphorylated inositol phospholipids, provide a circuit board of on/off switches for attracting or repelling proteins that define the membranes of the cell. This template of charged phospholipids is sensitive to discrete changes and metabolic fluxes-e.g., in pH and cations-which contribute to the oscillating signals in the cell. The inherent complexities of a constantly fluctuating system make understanding how plants integrate and process signals challenging. In this review we discuss one aspect of lipid signaling: the inositol family of negatively charged phospholipids and their functions as molecular sensors and regulators of metabolic flux in plants.

  4. Combined optical coherence tomography morphologic and fractional flow reserve hemodynamic assessment of non- culprit lesions to better predict adverse event outcomes in diabetes mellitus patients: COMBINE (OCT-FFR) prospective study. Rationale and design.

    Science.gov (United States)

    Kennedy, Mark W; Fabris, Enrico; Ijsselmuiden, Alexander J; Nef, Holger; Reith, Sebastian; Escaned, Javier; Alfonso, Fernando; van Royen, Niels; Wojakowski, Wojtek; Witkowski, Adam; Indolfi, Ciro; Ottervanger, Jan Paul; Suryapranata, Harry; Kedhi, Elvin

    2016-10-10

    Fractional flow reserve (FFR) is a widely used tool for the identification of ischaemia-generating stenoses and to guide decisions on coronary revascularisation. However, the safety of FFR-based decisions in high-risk subsets, such as patients with Diabetes Mellitus (DM) or vulnerable stenoses presenting thin-cap fibro-atheroma (TCFA), is unknown. This study will examine the impact of optical coherence tomography (OCT) plaque morphological assessment and the identification of TCFA, in combination with FFR to better predict clinical outcomes in DM patients. COMBINE (OCT-FFR) is a prospective, multi-centre study investigating the natural history of DM patients with ≥1 angiographically intermediate target lesion in three subgroups of patients; patients with FFR negative lesions without TCFA (group A) and patients with FFR negative lesions with TCFA (group B) as detected by OCT and to compare these two groups with each other, as well as to a third group with FFR-positive, PCI-treated intermediate lesions (group C). The study hypothesis is that DM patients with TCFA (group B) have a worse outcome than those without TCFA (group A) and also when compared to those patients with lesions FFR ≤0.80 who underwent complete revascularisation. The primary endpoint is the incidence of target lesion major adverse cardiac events (MACE); a composite of cardiac death, myocardial infarction or rehospitalisation for unstable/progressive angina in group B vs. group A. COMBINE (OCT-FFR) is the first prospective study to examine whether the addition of OCT plaque morphological evaluation to FFR haemodynamic assessment of intermediate lesions in DM patients will better predict MACE and possibly lead to new revascularisation strategies. Trial Registration Netherlands Trial Register: NTR5376.

  5. Machine intelligence and signal processing

    CERN Document Server

    Vatsa, Mayank; Majumdar, Angshul; Kumar, Ajay

    2016-01-01

    This book comprises chapters on key problems in machine learning and signal processing arenas. The contents of the book are a result of a 2014 Workshop on Machine Intelligence and Signal Processing held at the Indraprastha Institute of Information Technology. Traditionally, signal processing and machine learning were considered to be separate areas of research. However in recent times the two communities are getting closer. In a very abstract fashion, signal processing is the study of operator design. The contributions of signal processing had been to device operators for restoration, compression, etc. Applied Mathematicians were more interested in operator analysis. Nowadays signal processing research is gravitating towards operator learning – instead of designing operators based on heuristics (for example wavelets), the trend is to learn these operators (for example dictionary learning). And thus, the gap between signal processing and machine learning is fast converging. The 2014 Workshop on Machine Intel...

  6. Design junctions

    DEFF Research Database (Denmark)

    Jørgensen, Ulrik

    2012-01-01

    This article discusses the question: Are weak signals independent of framing and interactions with the environment? The response proposed here is that many of the developments identified by efforts to detect and interpret weak signals are the result of designed interventions that define the reper......This article discusses the question: Are weak signals independent of framing and interactions with the environment? The response proposed here is that many of the developments identified by efforts to detect and interpret weak signals are the result of designed interventions that define...... given to weak signals are strongly influenced by design choices made at the outset. In this sense design is a constitutive element of both the environment and signal detection/use. An example of how design is constitutive of both context and understanding can be found in the history of hospital hygiene....... This case study illustrates how dominant regimes of practice, established through the conception of pathogen bacteria and antibacterial treatments and disinfection, are now creating signals that call into question fundamental design of hygiene practices. By examining the epistemic assumptions of scientific...

  7. Estimating Foreign Exchange Reserve Adequacy

    Directory of Open Access Journals (Sweden)

    Abdul Hakim

    2013-04-01

    Full Text Available Accumulating foreign exchange reserves, despite their cost and their impacts on other macroeconomics variables, provides some benefits. This paper models such foreign exchange reserves. To measure the adequacy of foreign exchange reserves for import, it uses total reserves-to-import ratio (TRM. The chosen independent variables are gross domestic product growth, exchange rates, opportunity cost, and a dummy variable separating the pre and post 1997 Asian financial crisis. To estimate the risky TRM value, this paper uses conditional Value-at-Risk (VaR, with the help of Glosten-Jagannathan-Runkle (GJR model to estimate the conditional volatility. The results suggest that all independent variables significantly influence TRM. They also suggest that the short and long run volatilities are evident, with the additional evidence of asymmetric effects of negative and positive past shocks. The VaR, which are calculated assuming both normal and t distributions, provide similar results, namely violations in 2005 and 2008.

  8. Cognitive Reserve Scale and ageing

    Directory of Open Access Journals (Sweden)

    Irene León

    2016-01-01

    Full Text Available The construct of cognitive reserve attempts to explain why some individuals with brain impairment, and some people during normal ageing, can solve cognitive tasks better than expected. This study aimed to estimate cognitive reserve in a healthy sample of people aged 65 years and over, with special attention to its influence on cognitive performance. For this purpose, it used the Cognitive Reserve Scale (CRS and a neuropsychological battery that included tests of attention and memory. The results revealed that women obtained higher total CRS raw scores than men. Moreover, the CRS predicted the learning curve, short-term and long-term memory, but not attentional and working memory performance. Thus, the CRS offers a new proxy of cognitive reserve based on cognitively stimulating activities performed by healthy elderly people. Following an active lifestyle throughout life was associated with better intellectual performance and positive effects on relevant aspects of quality of life.

  9. Fractional Reserve Banking: Some Quibbles

    OpenAIRE

    Bagus, Philipp; Howden, David

    2010-01-01

    We explore several unaddressed issues in George Selgin’s (1988) claim that the best monetary system to maintain monetary equilibrium is a fractional reserve free banking one. The claim that adverse clearing balances would limit credit expansion in a fractional reserve free banking system is more troublesome than previously reckoned. Both lengthened clearing periods and interbank agreements render credit expansion unrestrained. “The theory of free banking” confuses increases in money held with...

  10. Efficient Allocation of Reserve Costs in RTO Markets

    Energy Technology Data Exchange (ETDEWEB)

    Kirsch, Laurence D.; Morey, Mathew J.

    2006-10-15

    RTOs' make-whole payments for generation commitment are needed partly because of flaws in the design of reserve markets. Markets might be made more efficient with greater locational differentiation in reserve prices and incorporation of make-whole payments into reserve prices. (author)

  11. Reserve Retirement Equality: Treating Reserves Fairly While Saving Taxpayer Dollars

    Science.gov (United States)

    2010-06-09

    rata .121 For example, a Reserve who performs the equivalent of five years of active duty, will receive one-fourth the retired pay of his active duty...4,225 per month.124 But because reserve-retirement benefits are based on pro rata years of service, this officer’s years of service for retirement...purposes are 3,146 retirement points divided by 360.125 This results in 8.74 years pro rata years of service.126 His retirement benefits thus are

  12. Reserve Component Personnel Issues: Questions and Answers

    Science.gov (United States)

    2017-01-18

    of one day of basic pay for each unit training assembly ( UTA ) they attend. A UTA is generally a four-hour period of instruction, and there are usually...training assembly ( UTA ), one point for each day of annual training (AT), and one point for each day of active duty. Points can also be earned for completing... on the vitality of the reserve components, such as funding, equipment, and personnel policy. This report is designed to provide an overview of key

  13. Pragmatic circuits signals and filters

    CERN Document Server

    Eccles, William

    2006-01-01

    Pragmatic Circuits: Signals and Filters is built around the processing of signals. Topics include spectra, a short introduction to the Fourier series, design of filters, and the properties of the Fourier transform. The focus is on signals rather than power. But the treatment is still pragmatic. For example, the author accepts the work of Butterworth and uses his results to design filters in a fairly methodical fashion. This third of three volumes finishes with a look at spectra by showing how to get a spectrum even if a signal is not periodic. The Fourier transform provides a way of dealing wi

  14. Signal integrity characterization techniques

    CERN Document Server

    Bogatin, Eric

    2009-01-01

    "Signal Integrity Characterization Techniques" addresses the gap between traditional digital and microwave curricula all while focusing on a practical and intuitive understanding of signal integrity effects within the data transmission channel. High-speed interconnects such as connectors, PCBs, cables, IC packages, and backplanes are critical elements of differential channels that must be designed using today's most powerful analysis and characterization tools.Both measurements and simulation must be done on the device under test, and both activities must yield data that correlates with each other. Most of this book focuses on real-world applications of signal integrity measurements - from backplane for design challenges to error correction techniques to jitter measurement technologies. The authors' approach wisely addresses some of these new high-speed technologies, and it also provides valuable insight into its future direction and will teach the reader valuable lessons on the industry.

  15. Improved Effectiveness of Reserve Forces During Reserve Duty Training.

    Science.gov (United States)

    Treadaway, Harry H.

    The problem areas of motivation, job enrichment, recruiting, and retention are addressed from the viewpoint of the behavioral scientist. Special attention is given to relating job enrichment and motivation techniques, as successfully demonstrated in industry, to the United State Army Reserve. Research method utilized was a literature review…

  16. Spinning Reserve From Responsive Loads

    Energy Technology Data Exchange (ETDEWEB)

    Kirby, B.J.

    2003-04-08

    Responsive load is the most underutilized reliability resource available to the power system today. It is currently not used at all to provide spinning reserve. Historically there were good reasons for this, but recent technological advances in communications and controls have provided new capabilities and eliminated many of the old obstacles. North American Electric Reliability Council (NERC), Federal Energy Regulatory Commission (FERC), Northeast Power Coordinating Council (NPCC), New York State Reliability Council (NYSRC), and New York Independent System Operator (NYISO) rules are beginning to recognize these changes and are starting to encourage responsive load provision of reliability services. The Carrier ComfortChoice responsive thermostats provide an example of these technological advances. This is a technology aimed at reducing summer peak demand through central control of residential and small commercial air-conditioning loads. It is being utilized by Long Island Power Authority (LIPA), Consolidated Edison (ConEd), Southern California Edison (SCE), and San Diego Gas and Electric (SDG&E). The technology is capable of delivering even greater response in the faster spinning reserve time frame (while still providing peak reduction). Analysis of demand reduction testing results from LIPA during the summer of 2002 provides evidence to back up this claim. It also demonstrates that loads are different from generators and that the conventional wisdom, which advocates for starting with large loads as better ancillary service providers, is flawed. The tempting approach of incrementally adapting ancillary service requirements, which were established when generators were the only available resources, will not work. While it is easier for most generators to provide replacement power and non-spinning reserve (the slower response services) than it is to supply spinning reserve (the fastest service), the opposite is true for many loads. Also, there is more financial

  17. Cerebral correlates of cognitive reserve.

    Science.gov (United States)

    Whalley, Lawrence J; Staff, Roger T; Fox, Helen C; Murray, Alison D

    2016-01-30

    Cognitive reserve is a hypothetical concept introduced to explain discrepancies between severity of clinical dementia syndromes and the extent of dementia pathology. We examined cognitive reserve in a research programme that followed up a non-clinical sample born in 1921 or 1936 and IQ-tested age 11 years in 1932 or 1947. Structural MRI exams were acquired in about 50% of the sample from whom a subsample were recruited into an additional fMRI study. Here, we summarise findings from seven inter-related studies. These support an understanding of cognitive reserve as a balance between positive life course activity-driven experiences and the negative effects of brain pathologies including cerebrovascular disease and total and regional brain volume loss. Hypothesised structural equation models illustrate the relative causal effects of these positive and negative contributions. Cognitive reserve is considered in the context of choice of interventions to prevent dementia and the opposing effects of cerebrovascular disease and Alzheimer like brain appearances. Crown Copyright © 2015. Published by Elsevier Ireland Ltd. All rights reserved.

  18. Extractive reserves in Brazilian Amazonia

    Energy Technology Data Exchange (ETDEWEB)

    Fearnside, P.M (National Institute for Research in the Amazon, Manaus-Amazonas (Brazil))

    1989-06-01

    In 1985 an opportunity arose for maintaining tracts of Amazonian forest under sustainable use. Brazil's National Council of Rubber Tappers and the Rural Worker's Union proposed the creation of a set of reserves of a new type, called extractive reserves. The first six are being established in one of the Brazilian states most threatened by deforestatation. The creation of extractive reserves grants legal protection to forest land traditionally used by rubber tappers, Brazil-nut gatherers, and other extractivists. The term extrativismo (extractivism) in Brazil refers to removing nontimber forest products, such as latex, resins, and nuts, without felling the trees. Approximately 30 products are collected for commercial sale. Many more types of forest materials are gathered, for example as food and medicines, for the extractivists' own use. The reserve proposal is attractive for several reasons related to social problems. It allows the rubber tappers to continue their livelihood rather than be expelled by deforestation. However, it is unlikely that sufficient land will be set aside as extractive reserves to employ all the tappers. Displaced rubber tappers already swell the ranks of urban slum dwellers in Brazil's Amazonian cities, and they have become refugees to continue their profession in the forests of neighboring countries, such as Bolivia.

  19. Analog signal isolation techniques

    Energy Technology Data Exchange (ETDEWEB)

    Beadle, E.R.

    1992-12-31

    This paper discusses several techniques for isolating analog signals in an accelerator environment. The techniques presented here encompass isolation amplifiers, voltage-to-frequency converters (VIFCs), transformers, optocouplers, discrete fiber optics, and commercial fiber optic links. Included within the presentation of each method are the design issues that must be considered when selecting the isolation method for a specific application.

  20. Analog signal isolation techniques

    Energy Technology Data Exchange (ETDEWEB)

    Beadle, E.R.

    1992-01-01

    This paper discusses several techniques for isolating analog signals in an accelerator environment. The techniques presented here encompass isolation amplifiers, voltage-to-frequency converters (VIFCs), transformers, optocouplers, discrete fiber optics, and commercial fiber optic links. Included within the presentation of each method are the design issues that must be considered when selecting the isolation method for a specific application.

  1. Hydrocarbon Reserves: Abundance or Scarcity

    International Nuclear Information System (INIS)

    2005-01-01

    IFP and the OAPEC jointly organize a regular international seminar dealing with world oil-related problems appearing in the news. For the first time, this seminar has been opened to oil and gas company specialists, service companies, research centers and independents. This year's theme concerns oil and gas reserves: are they abundant or are we headed towards the shortages announced by some experts? This theme is especially topical in that: oil and gas currently meet two thirds of world energy needs and almost completely dominate the transport sector; the reserves declared by the OAPEC countries account for nearly half of world reserves; the price of a barrel of oil went through the roof in 2004; world energy demand is growing fast and alternative sources of energy are far from ready to take over from oil and gas in the next few decades. Since the reserves correspond to the volume it is technically and economically viable to produce, the seminar has, of course, dealt with the technical and economic questions that arise in connection with exploration and production, but it has also considered changes in the geopolitical context. Presentations by the leading companies of the OAPEC countries and by the IFP group were completed by presentation from the International Energy Agency (IEA), the United States Geological Survey (USGS), the IHS Energy Group, Total and Gaz de France. This document gathers the transparencies of the following presentations: Hydrocarbon reserves in OAPEC members countries: current and future (M. Al-Lababidi); Non OAPEC liquid reserves and production forecasts (Y. Mathieu); World oil and gas resources and production outlook (K. Chew); Global investments in the upstream (F. Birol); Total's policy in the oil and gas sector (C. de Margerie); Gaz de France's policy in the oil and gas sector (J. Abiteboul); NOC/IOC's opportunities in OPEC countries (I. Sandrea); Relationships between companies, countries and investors: How they may impact on the growth

  2. Hydrocarbon Reserves: Abundance or Scarcity

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    IFP and the OAPEC jointly organize a regular international seminar dealing with world oil-related problems appearing in the news. For the first time, this seminar has been opened to oil and gas company specialists, service companies, research centers and independents. This year's theme concerns oil and gas reserves: are they abundant or are we headed towards the shortages announced by some experts? This theme is especially topical in that: oil and gas currently meet two thirds of world energy needs and almost completely dominate the transport sector; the reserves declared by the OAPEC countries account for nearly half of world reserves; the price of a barrel of oil went through the roof in 2004; world energy demand is growing fast and alternative sources of energy are far from ready to take over from oil and gas in the next few decades. Since the reserves correspond to the volume it is technically and economically viable to produce, the seminar has, of course, dealt with the technical and economic questions that arise in connection with exploration and production, but it has also considered changes in the geopolitical context. Presentations by the leading companies of the OAPEC countries and by the IFP group were completed by presentation from the International Energy Agency (IEA), the United States Geological Survey (USGS), the IHS Energy Group, Total and Gaz de France. This document gathers the transparencies of the following presentations: Hydrocarbon reserves in OAPEC members countries: current and future (M. Al-Lababidi); Non OAPEC liquid reserves and production forecasts (Y. Mathieu); World oil and gas resources and production outlook (K. Chew); Global investments in the upstream (F. Birol); Total's policy in the oil and gas sector (C. de Margerie); Gaz de France's policy in the oil and gas sector (J. Abiteboul); NOC/IOC's opportunities in OPEC countries (I. Sandrea); Relationships between companies, countries and investors: How they may

  3. Risk spreading, connectivity, and optimal reserve spacing.

    Science.gov (United States)

    Blowes, Shane A; Connolly, Sean R

    2012-01-01

    recovery and persistence to how covariance of vital rates decreases with distance suggests that estimating the shape of this function is likely to be as important for effective reserve design as estimating connectivity. Similarly, because temporal variation in dispersal dynamics influences the effect of reserve spacing, approaches to reserve design that ignore such variation, and rely instead on long-term average dispersal patterns, are likely to lead to lower metapopulation viability than is actually achievable.

  4. Evaluation of cardiac signals using discrete wavelet transform with MATLAB graphical user interface.

    Science.gov (United States)

    John, Agnes Aruna; Subramanian, Aruna Priyadharshni; Jaganathan, Saravana Kumar; Sethuraman, Balasubramanian

    2015-01-01

    To process the electrocardiogram (ECG) signals using MATLAB-based graphical user interface (GUI) and to classify the signals based on heart rate. The subject condition was identified using R-peak detection based on discrete wavelet transform followed by a Bayes classifier that classifies the ECG signals. The GUI was designed to display the ECG signal plot. Obtained from MIT database 18 patients had normal heart rate and 9 patients had abnormal heart rate; 14.81% of the patients suffered from tachycardia and 18.52% of the patients have bradycardia. The proposed GUI display was found useful to analyze the digitized ECG signal by a non-technical user and may help in diagnostics. Further improvement can be done by employing field programmable gate array for the real time processing of cardiac signals. Copyright © 2015 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

  5. 77 FR 40253 - Reserve Account

    Science.gov (United States)

    2012-07-09

    .... The commentators represented Rural Development employees who work with the Multi-Family Housing Direct... their annual over-inflated tax bills and assessments. As a result, rent income funding that could be..., as rents cannot be raised to an amount that will cover all current and future reserve expenses...

  6. Demand as Frequency Controlled Reserve

    DEFF Research Database (Denmark)

    Xu, Zhao; Togeby, Mikael; Østergaard, Jacob

    This report summaries the research outcomes of the project ‘Demand as Frequency Controlled Reserve (DFR)’, which has received the support from Energinet.dk’s PSO program, Grant no. 2005-2-6380. The objective of this project is to investigate the technology of using electricity demands for providing...

  7. VLSI signal processing technology

    CERN Document Server

    Swartzlander, Earl

    1994-01-01

    This book is the first in a set of forthcoming books focussed on state-of-the-art development in the VLSI Signal Processing area. It is a response to the tremendous research activities taking place in that field. These activities have been driven by two factors: the dramatic increase in demand for high speed signal processing, especially in consumer elec­ tronics, and the evolving microelectronic technologies. The available technology has always been one of the main factors in determining al­ gorithms, architectures, and design strategies to be followed. With every new technology, signal processing systems go through many changes in concepts, design methods, and implementation. The goal of this book is to introduce the reader to the main features of VLSI Signal Processing and the ongoing developments in this area. The focus of this book is on: • Current developments in Digital Signal Processing (DSP) pro­ cessors and architectures - several examples and case studies of existing DSP chips are discussed in...

  8. Signaling modalities during oogenesis in mammals.

    Science.gov (United States)

    McGinnis, Lynda K; Limback, S Darlene; Albertini, David F

    2013-01-01

    During oogenesis in mammals, the germ line interacts with ovarian somatic cells as follicles assemble, grow, ovulate, and die. As a result, these interactions with granulosa cells determine germ cell fate as the oocyte undergoes hypertrophy, the final stages of meiosis, and preparations required for successful fertilization. Over the past 15 years, investigators using a range of experimental approaches have uncovered the existence of multiple modalities for signaling between the oocyte and companion granulosa cells that play essential and sometimes overlapping roles during the growth and maturative phases of oogenesis. Five modalities of intercellular signaling are considered in the context of regulating oocyte gene expression, metabolism, spatial patterning, and the cell cycle. While some forms of signaling predominate at specific stages of oogenesis, such as during the assembly of primordial follicles, it is apparent that combinations of modalities work in concert to control events associated with ovulation when both nuclear and cytoplasmic maturation occur. A final key feature of the signaling platform underscoring the protracted process of oogenesis is the existence of negative and positive feedback loops designed to coordinate the tempo of oogenesis and folliculogenesis at key developmental transitions. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. Sparse signal representation and its applications in ultrasonic NDE.

    Science.gov (United States)

    Zhang, Guang-Ming; Zhang, Cheng-Zhong; Harvey, David M

    2012-03-01

    Many sparse signal representation (SSR) algorithms have been developed in the past decade. The advantages of SSR such as compact representations and super resolution lead to the state of the art performance of SSR for processing ultrasonic non-destructive evaluation (NDE) signals. Choosing a suitable SSR algorithm and designing an appropriate overcomplete dictionary is a key for success. After a brief review of sparse signal representation methods and the design of overcomplete dictionaries, this paper addresses the recent accomplishments of SSR for processing ultrasonic NDE signals. The advantages and limitations of SSR algorithms and various overcomplete dictionaries widely-used in ultrasonic NDE applications are explored in depth. Their performance improvement compared to conventional signal processing methods in many applications such as ultrasonic flaw detection and noise suppression, echo separation and echo estimation, and ultrasonic imaging is investigated. The challenging issues met in practical ultrasonic NDE applications for example the design of a good dictionary are discussed. Representative experimental results are presented for demonstration. Copyright © 2011 Elsevier B.V. All rights reserved.

  10. A Class of Optimal Rectangular Filtering Matrices for Single-Channel Signal Enhancement in the Time Domain

    DEFF Research Database (Denmark)

    Jensen, Jesper Rindom; Benesty, Jacob; Christensen, Mads Græsbøll

    2013-01-01

    in the filters, that are otherwise reserved for preserving the signal subspace, can be used for achieving an improved output signal-to-noise ratio (SNR). Moreover, the filters allow for explicit control of the tradeoff between noise reduction and speech distortion via the chosen rank of the signal subspace...... and real signals. The results show a number of interesting things. Firstly, they show how speech distortion can be traded for noise reduction and vice versa in a seamless manner. Moreover, the introduced filter designs are capable of achieving both the upper and lower bounds for the output SNR via...

  11. Electronic signal conditioning

    CERN Document Server

    NEWBY, BRUCE

    1994-01-01

    At technician level, brief references to signal conditioning crop up in a fragmented way in various textbooks, but there has been no single textbook, until now!More advanced texts do exist but they are more mathematical and presuppose a higher level of understanding of electronics and statistics. Electronic Signal Conditioning is designed for HNC/D students and City & Guilds Electronics Servicing 2240 Parts 2 & 3. It will also be useful for BTEC National, Advanced GNVQ, A-level electronics and introductory courses at degree level.

  12. Unified Facilities Criteria (UFC) Design Guide. Army Reserve Facilities

    Science.gov (United States)

    2010-02-01

    bike racks...3-6.1.2.5 Entrance-type carpeting should be provided at all major training center entrances to minimize tracking of dirt , mud and snow into the...space is authorized for units with soils testing functions, and should be located near an exterior door to minimize tracking of dirt by field

  13. The principle of complementarity in the design of reserve networks ...

    Indian Academy of Sciences (India)

    This paper sketches the historical development of the principle of complementarity and its applications in practical policy decisions. In the first section a brief account is given of the circumstances out of which concerns for more explicit systematic methods for the assessment of the conservation value of different areas arose.

  14. Uranium reserves and exploration activity

    International Nuclear Information System (INIS)

    Meehan, R.J.

    1975-01-01

    The strategy that ERDA plans to employ regarding resource appraisal is outlined. All types of uranium occurrences will be evaluated as sources of domestic ore reserves. Industry's exploration efforts will be compiled. These data will include information on land acquisition and costs, footage drilled and costs, estimates of exploration activities and expenditures, exploration for non-sandstone deposits, exploration in non-established areas, and foreign exploration plans and costs. Typical data in each of these areas are given

  15. Gas reserves, discoveries and production

    International Nuclear Information System (INIS)

    Saniere, A.

    2006-01-01

    Between 2000 and 2004, new discoveries, located mostly in the Asia/Pacific region, permitted a 71% produced reserve replacement rate. The Middle East and the offshore sector represent a growing proportion of world gas production Non-conventional gas resources are substantial but are not exploited to any significant extent, except in the United States, where they account for 30% of U.S. gas production. (author)

  16. Demand Response Spinning Reserve Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Eto, Joseph H.; Nelson-Hoffman, Janine; Torres, Carlos; Hirth,Scott; Yinger, Bob; Kueck, John; Kirby, Brendan; Bernier, Clark; Wright,Roger; Barat, A.; Watson, David S.

    2007-05-01

    The Demand Response Spinning Reserve project is a pioneeringdemonstration of how existing utility load-management assets can providean important electricity system reliability resource known as spinningreserve. Using aggregated demand-side resources to provide spinningreserve will give grid operators at the California Independent SystemOperator (CAISO) and Southern California Edison (SCE) a powerful, newtool to improve system reliability, prevent rolling blackouts, and lowersystem operating costs.

  17. Indian Reserves: Canada's Developing Nations

    OpenAIRE

    Musto, Richard J.

    1990-01-01

    Indian reserves are the most visible reminder of the separation of aboriginal people from the rest of Canada and other Canadians. Illness patterns and social conditions in Native communities closely parallel those in developing nations. While they continue to have a large burden of infectious diseases, these groups also have an increased incidence of chronic and lifestyle diseases as well as environment-related conditions. Similarities can be seen in urban areas between immigrants from abroad...

  18. Signals and systems with MATLAB

    CERN Document Server

    Yang, Won Young; Song, Ik H; Cho, Yong S

    2009-01-01

    Covers some of the theoretical foundations and mathematical derivations that can be used in higher-level related subjects such as signal processing, communication, and control, minimizing the mathematical difficulty and computational burden. This book illustrates the usage of MATLAB and Simulink for signal and system analysis and design.

  19. Development of an electronic vehicular traffic signal controller ...

    African Journals Online (AJOL)

    This paper presents the design, construction, and test of an electronic signal controller for urban vehicular traffic control. The design is based on a series of fixed-time signal plans for different time zones of the day and can accommodate sixty-four signal plans. Finite state machine concept was used in the design of the signal ...

  20. Nuclear Receptor Signaling Atlas (NURSA)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Nuclear Receptor Signaling Atlas (NURSA) is designed to foster the development of a comprehensive understanding of the structure, function, and role in disease...

  1. Design and implementation of a radiation hardened silicon on sapphire (SOS) embedded signal conditioning unit controller (SCUC) for the RAPID instrument on the Cluster satellites

    International Nuclear Information System (INIS)

    Ersland, L.

    1992-07-01

    The Cluster mission consistens of four spacecrafts equipped with instruments capable of making comprehensive measurements of plasma particles and electromagnetic fields. The RAPID (Research with Adaptive Particle Imaging Detectors) spectrometer is one of many instruments on board the Cluster satellites. It is designed for fast analysis of energetic electrons and ions with a complete coverage of the unit sphere in phase space. This thesis describes the development and testing of an embedded controller for the Spectroscopic Camera for Electrons, Neutral and Ion Compositions (SCENIC), which is a part of the RAPID instrument. The design is implemented in two different CMOS circuit technologies, namely Actel's Field Programmable Gate Arrays and GEC Plessey's CMOS Silicon On Sapphire (SOS) gate array. The prototypes of the SOS gate array have been verified and characterized. This includes measurements of DC and AC parameters under different conditions, including total dose of gamma irradiation. 42 refs., 92 figs., 44 tabs

  2. Small-Signal Modeling of the PVR-Based AD Scheme and Controller Design for Three-Phase Standalone DG System

    DEFF Research Database (Denmark)

    Shen, Pan; Han, Yang; Lu, Chang

    2016-01-01

    )-based active damping (AD) method for the islanded DG system using an extra feedback capacitor current shaping loop in the stationary reference frame to provide an AD to suppress the resonance-peak of the LC filter and improve both steady-state and transient performances, the inner voltage and current...... systematic controller parameters design procedure is presented. Finally, simulation and experimental results are provided to validate the effectiveness of the proposed strategy....

  3. Foreign Exchange Reserves: Bangladesh Perspective

    Directory of Open Access Journals (Sweden)

    Md Zahangir Alam

    2013-10-01

    Full Text Available This study is about foreign exchangereserves of Bangladesh. The mainpurpose of this study is to the influence of exchange rates on foreign exchangereserves to the Bangladesh context.  Both the primary and secondary data has been used inthis study. The primary data has been collected through a structuredquestionnaire from 50 respondents. The secondary data, namely Bangladeshforeign exchange reserves (FER, Bangladesh current account balance (CAB,Bangladesh capital andfinancial account balance (CFAB, and BDT/USD exchange rates (ER.  This study covers yearly data from July 01,1996 to June 30, 2005 and quarterly data from July 01, 2005 to June 30, 2012. Findingsof this study shows that out of the selected 16 factors affecting foreignexchange reserves, exchange rates occupy the first position, weighted averagescore (WAS being 4.56. Foreign exchange reserves (FER and current accountbalance (CAB have increased by 502.9087% and 1451.218%,whereas capital and financial account (CFAB has decreased by -649.024% on June30, 2012 compared to June 30, 1997. The influence of other factors heldconstant, as ER changes by 285.6894 units due to one unit change in FER, onaverage in the same direction which represents that ER has positive effect on theFER and this relationship is statistically significant.  62.1526 percentof the variation in FER is explained by ER. The outcomes of Breusch-Godfrey test (LM test, ARCHtest, and the Normality test are that there is a serial correlation among residuals, the variance of residuals is notconstant, and the residuals are not normally distributed.

  4. Brain reserve and cognitive reserve in multiple sclerosis

    Science.gov (United States)

    Rocca, Maria A.; Leavitt, Victoria M.; Riccitelli, Gianna; Comi, Giancarlo; DeLuca, John; Filippi, Massimo

    2013-01-01

    Objective: We first tested the brain reserve (BR) hypothesis in multiple sclerosis (MS) by examining whether larger maximal lifetime brain volume (MLBV; determined by genetics) protects against disease-related cognitive impairment, and then investigated whether cognitive reserve (CR) gained through life experience (intellectually enriching leisure activities) protects against cognitive decline independently of MLBV (BR). Methods: Sixty-two patients with MS (41 relapsing-remitting MS, 21 secondary progressive MS) received MRIs to estimate BR (MLBV, estimated with intracranial volume [ICV]) and disease burden (T2 lesion load; atrophy of gray matter, white matter, thalamus, and hippocampus). Early-life cognitive leisure was measured as a source of CR. We assessed cognitive status with tasks of cognitive efficiency and memory. Hierarchical regressions were used to investigate whether higher BR (ICV) protects against cognitive impairment, and whether higher CR (leisure) independently protects against cognitive impairment over and above BR. Results: Cognitive status was positively associated with ICV (R2 = 0.066, p = 0.017). An ICV × disease burden interaction (R2 = 0.050, p = 0.030) revealed that larger ICV attenuated the impact of disease burden on cognition. Controlling for BR, higher education (R2 = 0.047, p = 0.030) and leisure (R2 = 0.090, p = 0.001) predicted better cognition. A leisure × disease burden interaction (R2 = 0.037, p = 0.030) showed that leisure independently attenuated the impact of disease burden on cognition. Follow-up analyses revealed that BR protected against cognitive inefficiency, not memory deficits, whereas CR was more protective against memory deficits than cognitive inefficiency. Conclusion: We provide evidence of BR in MS, and show that CR independently protects against disease-related cognitive decline over and above BR. Lifestyle choices protect against cognitive impairment independently of genetic factors outside of one's control

  5. Essays in the California electricity reserves markets

    Science.gov (United States)

    Metaxoglou, Konstantinos

    This dissertation examines inefficiencies in the California electricity reserves markets. In Chapter 1, I use the information released during the investigation of the state's electricity crisis of 2000 and 2001 by the Federal Energy Regulatory Commission to diagnose allocative inefficiencies. Building upon the work of Wolak (2000), I calculate a lower bound for the sellers' price-cost margins using the inverse elasticities of their residual demand curves. The downward bias in my estimates stems from the fact that I don't account for the hierarchical substitutability of the reserve types. The margins averaged at least 20 percent for the two highest quality types of reserves, regulation and spinning, generating millions of dollars in transfers to a handful of sellers. I provide evidence that the deviations from marginal cost pricing were due to the markets' high concentration and a principal-agent relationship that emerged from their design. In Chapter 2, I document systematic differences between the markets' day- and hour-ahead prices. I use a high-dimensional vector moving average model to estimate the premia and conduct correct inferences. To obtain exact maximum likelihood estimates of the model, I employ the EM algorithm that I develop in Chapter 3. I uncover significant day-ahead premia, which I attribute to market design characteristics too. On the demand side, the market design established a principal-agent relationship between the markets' buyers (principal) and their supervisory authority (agent). The agent had very limited incentives to shift reserve purchases to the lower priced hour-ahead markets. On the supply side, the market design raised substantial entry barriers by precluding purely speculative trading and by introducing a complicated code of conduct that induced uncertainty about which actions were subject to regulatory scrutiny. In Chapter 3, I introduce a state-space representation for vector autoregressive moving average models that enables

  6. Award 1 Title: Acoustic Communications 2011 Experiment: Deployment Support and Post Experiment Data Handling and Analysis. Award 2 Title: Exploiting Structured Dependencies in the Design of Adaptive Algorithms for Underwater Communication Award. 3 Title: Coupled Research in Ocean Acoustics and Signal Processing for the Next Generation of Underwater Acoustic Communication Systems

    Science.gov (United States)

    2015-09-30

    Exploiting Structured Dependencies in the Design of Adaptive Algorithms for Underwater Communication Award #3 Title Coupled Research in Ocean Acoustics ...and Signal Processing for theNext Generation of Underwater Acoustic Communication Systems James Preisig Woods Hole Oceanographic Institution...Dept. of Applied Ocean Physics and Engineering Ocean Acoustics and Signals Laboratory Woods Hole, MA 02540 AND JPAnalytics LLC 638 Brick Kiln

  7. Signal generation in gas detectors

    International Nuclear Information System (INIS)

    Stillman, A.

    1993-01-01

    This tutorial describes the generation of electrical signals in gas detectors. Ionization of the gas by the passage of charged particles generates these signals. Starting with the Bethe-Bloch equation, the treatment is a general introduction to the production of ion-pairs in gas devices. I continue with the characterization of the ionization as an electrical signal, and calculate the signal current in a simple example. Another example demonstrates the effect of space charge on the design of a detector. The AGS Booster ionization profile monitor is a model for this calculation

  8. Signal generation in gas detectors

    Energy Technology Data Exchange (ETDEWEB)

    Stillman, A.

    1993-11-01

    This tutorial describes the generation of electrical signals in gas detectors. Ionization of the gas by the passage of charged particles generates these signals. Starting with the Bethe-Bloch equation, the treatment is a general introduction to the production of ion-pairs in gas devices. I continue with the characterization of the ionization as an electrical signal, and calculate the signal current in a simple example. Another example demonstrates the effect of space charge on the design of a detector. The AGS Booster ionization profile monitor is a model for this calculation.

  9. Experiment and practice on signal processing

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-11-15

    The contents of this book contains basic practice of CEM Tool, discrete time signal and experiment and practice of system, experiment and practice of discrete time signal sampling, practice of frequency analysis, experiment of digital filter design, application of digital signal processing, project related voice, basic principle of signal processing, the technique of basic image signal processing, biology astronomy and Robot soccer with apply of image signal processing technique, control video signal and project related image. It also has an introduction of CEM Linker I. O in the end.

  10. Z' reservation at LEP2

    CERN Document Server

    Montagna, G.; Piccinini, F.; Renard, F.M.; Verzegnassi, C.

    1995-01-01

    We consider the possibility that one extra Z\\equiv Z' exists with arbitrary mass and fermion couplings that do not violate (charged) lepton universality. We show that, in such a situation, a functional relationship is generated between the \\underline{deviations} from the SM values of three leptonic observables of two-fermion production at future e^+e^- colliders that is completely independent of the values of the Z' mass and couplings. This selects a certain region in the 3-d space of the deviations that is \\underline{characteristic} of the model (Z' "reservation"). As a specific and relevant example, we show the picture that would emerge at LEP2 under realistic experimental conditions.

  11. Prosocial Signalling

    DEFF Research Database (Denmark)

    Kahsay, Goytom Abraha

    signalling can cause reverse price reactions resembling the crowding-out of pre-existing motives for prosocial behavior seen in situations of volunteering and charitable giving. Using a unique combination of questionnaire and purchase panel data, it presents evidence of such reputation-driven reverse price...... reactions in the Danish market for organic milk. The second paper proposes a self-image model to account consumers’ behaviour under PWYW. It finds that when a good’s fixed price is lower than an exogenously given threshold fair value, PWYW can lead to a lower utility, which may lead to lower purchase rate...

  12. 7 CFR 985.57 - Reserve pool requirements.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE MARKETING ORDER REGULATING THE... commercial trade practices. The Committee shall designate a Committee employee as reserve pool manager. (b...

  13. Where to with reserve selection and conservation planning in South ...

    African Journals Online (AJOL)

    minimal set' approach to designing an optimal reserve network tor vertebrate species is offered. Strengths are the rational and efficient manner in which full species representation is achieved, and the planning benefits that can be gained through its ...

  14. 14 CFR 415.204-415.400 - [Reserved

    Science.gov (United States)

    2010-01-01

    ..., DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Environmental Review §§ 415.204—415.400 [Reserved] Pt... Subsystem Design Information 10.4Flight Safety System Analyses 10.5Flight Termination System Environmental...

  15. 49 CFR 392.51 - Reserve fuel; materials of trade.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Reserve fuel; materials of trade. 392.51 Section... COMMERCIAL MOTOR VEHICLES Fueling Precautions § 392.51 Reserve fuel; materials of trade. Small amounts of...) may be designated as materials of trade (see 49 CFR 171.8). (a) The aggregate gross weight of all...

  16. Computer Listing of a Reserve Collection. Occasional Papers, No. 6.

    Science.gov (United States)

    Gallivan, B.; And Others

    The computer-aided listing system developed for the short loan or reserve collection at the University of Lancaster should be applicable to other libraries. Designed for simplicity of operation, the system performs the following functions: (1) provides a master record of all books in the reserve collection at any given time, (2) facilitates the…

  17. Reviewing Biosphere Reserves globally: effective conservation action or bureaucratic label?

    Science.gov (United States)

    Coetzer, Kaera L; Witkowski, Edward T F; Erasmus, Barend F N

    2014-02-01

    The Biosphere Reserve (BR) model of UNESCO's Man and the Biosphere Programme reflects a shift towards more accountable conservation. Biosphere Reserves attempt to reconcile environmental protection with sustainable development; they explicitly acknowledge humans, and human interests in the conservation landscape while still maintaining the ecological values of existing protected areas. Conceptually, this model is attractive, with 610 sites currently designated globally. Yet the practical reality of implementing dual 'conservation' and 'development' goals is challenging, with few examples successfully conforming to the model's full criteria. Here, we review the history of Biosphere Reserves from first inception in 1974 to the current status quo, and examine the suitability of the designation as an effective conservation model. We track the spatial expansion of Biosphere Reserves globally, assessing the influence of the Statutory Framework of the World Network of Biosphere Reserves and Seville strategy in 1995, when the BR concept refocused its core objectives on sustainable development. We use a comprehensive range of case studies to discuss conformity to the Programme, the social and ecological consequences associated with implementation of the designation, and challenges in aligning conservation and development. Given that the 'Biosphere Reserve' label is a relatively unknown designation in the public arena, this review also provides details on popularising the Biosphere Reserve brand, as well as prospects for further research, currently unexploited, but implicit in the designation. © 2013 The Authors. Biological Reviews © 2013 Cambridge Philosophical Society.

  18. Design and synthesis of BODIPY-clickate based Hg(2+) sensors: the effect of triazole binding mode with Hg(2+) on signal transduction.

    Science.gov (United States)

    Vedamalai, Mani; Kedaria, Dhaval; Vasita, Rajesh; Mori, Shigeki; Gupta, Iti

    2016-02-14

    BODIPY-clickates, F1 and F2, for the detection of Hg(2+) have been designed, synthesized and characterized. Both F1 and F2 showed hyperchromic shifts in the UV-visible spectra in response to increasing Hg(2+) concentrations. Hg(2+) ion binding caused perturbation of the emission quenching process and chelation induced enhanced bathochromic emission of F1 and F2 to 620 nm and 660 nm, respectively. Job's plot clearly indicated that the binding ratio of F1 and F2 with Hg(2+) was 1 : 1. The NMR titration of BODIPY-clickates with Hg(2+) confirmed that aromatic amines and triazoles were involved in the binding event. Furthermore, HRMS data of F1-Hg(2+) and F2-Hg(2+) supported the formation of mercury complexes of BODIPY-clickates. The dissociation constant for the interaction between fluorescent probes F1 and F2 with Hg(2+) was found to be 24.4 ± 5.1 μM and 22.0 ± 3.9 μM, respectively. The Hg(2+) ion induced fluorescence enhancement was almost stable in a pH range of 5 to 8. Having less toxicity to live cells, both the probes were successfully used to map the Hg(2+) ions in live A549 cells.

  19. Power Efficient Design of DisplayPort (7.0) Using Low-voltage differential signaling IO Standard Via UltraScale Field Programming Gate Arrays

    DEFF Research Database (Denmark)

    Das, Bhagwan; Abdullah, M.F.L.; Hussain, Dil muhammed Akbar

    2017-01-01

    The DisplayPort (7.0) provides transection of serial-digital video displays, it has TX and RX Controllers along with pixel video interface, with streaming line rate of maximum 5.4 Gb/s. However, the limitation of DisplayPort (7.0) are detected in terms of power consumption. It has been reported...... that DisplayPort (7.0) consumes a massive power as it works on high frequency 1.62 GHz for high resolution video processing using HDMI Port. It is also stated that at full brightness the DisplayPort (7.0) consumes 49.0 W Therefore for power efficient DisplayPort (7.0) the full brightness power of Display...... Standard offers no power consumption for DisplayPort (7.0) in standby mode. The vhdl based design of DisplayPort (7.0) using LVDS IO Standard will be helpful to process the high resolution video at low power consumption....

  20. Handbook of signal processing systems

    CERN Document Server

    Bhattacharyya, Shuvra S; Leupers, Rainer; Takala, Jarmo

    2010-01-01

    The Handbook is organized in four parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications; the third part focuses on compilers and simulation tools; and the fourth part describes models of computation and their associated design tools and methodologies.

  1. Neuromelanin marks the spot: identifying a locus coeruleus biomarker of cognitive reserve in healthy aging.

    Science.gov (United States)

    Clewett, David V; Lee, Tae-Ho; Greening, Steven; Ponzio, Allison; Margalit, Eshed; Mather, Mara

    2016-01-01

    Leading a mentally stimulating life may build up a reserve of neural and mental resources that preserve cognitive abilities in late life. Recent autopsy evidence links neuronal density in the locus coeruleus (LC), the brain's main source of norepinephrine, to slower cognitive decline before death, inspiring the idea that the noradrenergic system is a key component of reserve (Robertson, I. H. 2013. A noradrenergic theory of cognitive reserve: implications for Alzheimer's disease. Neurobiol. Aging. 34, 298-308). Here, we tested this hypothesis using neuromelanin-sensitive magnetic resonance imaging to visualize and measure LC signal intensity in healthy younger and older adults. Established proxies of reserve, including education, occupational attainment, and verbal intelligence, were linearly correlated with LC signal intensity in both age groups. Results indicated that LC signal intensity was significantly higher in older than younger adults and significantly lower in women than in men. Consistent with the LC-reserve hypothesis, both verbal intelligence and a composite reserve score were positively associated with LC signal intensity in older adults. LC signal intensity was also more strongly associated with attentional shifting ability in older adults with lower cognitive reserve. Together these findings link in vivo estimates of LC neuromelanin signal intensity to cognitive reserve in normal aging. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Radar signal analysis and processing using Matlab

    CERN Document Server

    Mahafza, Bassem R

    2008-01-01

    Offering radar-related software for the analysis and design of radar waveform and signal processing, this book provides comprehensive coverage of radar signals and signal processing techniques and algorithms. It contains numerous graphical plots, common radar-related functions, table format outputs, and end-of-chapter problems. The complete set of MATLAB[registered] functions and routines are available for download online.

  3. Improving Deterministic Reserve Requirements for Security Constrained Unit Commitment and Scheduling Problems in Power Systems

    Science.gov (United States)

    Wang, Fengyu

    Traditional deterministic reserve requirements rely on ad-hoc, rule of thumb methods to determine adequate reserve in order to ensure a reliable unit commitment. Since congestion and uncertainties exist in the system, both the quantity and the location of reserves are essential to ensure system reliability and market efficiency. The modeling of operating reserves in the existing deterministic reserve requirements acquire the operating reserves on a zonal basis and do not fully capture the impact of congestion. The purpose of a reserve zone is to ensure that operating reserves are spread across the network. Operating reserves are shared inside each reserve zone, but intra-zonal congestion may block the deliverability of operating reserves within a zone. Thus, improving reserve policies such as reserve zones may improve the location and deliverability of reserve. As more non-dispatchable renewable resources are integrated into the grid, it will become increasingly difficult to predict the transfer capabilities and the network congestion. At the same time, renewable resources require operators to acquire more operating reserves. With existing deterministic reserve requirements unable to ensure optimal reserve locations, the importance of reserve location and reserve deliverability will increase. While stochastic programming can be used to determine reserve by explicitly modelling uncertainties, there are still scalability as well as pricing issues. Therefore, new methods to improve existing deterministic reserve requirements are desired. One key barrier of improving existing deterministic reserve requirements is its potential market impacts. A metric, quality of service, is proposed in this thesis to evaluate the price signal and market impacts of proposed hourly reserve zones. Three main goals of this thesis are: 1) to develop a theoretical and mathematical model to better locate reserve while maintaining the deterministic unit commitment and economic dispatch

  4. Intelligent Multimodal Signal Adaptation System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Micro Analysis and Design (MA&D) is pleased to submit this proposal to design an Intelligent Multimodal Signal Adaptation System. This system will dynamically...

  5. Are Private Reserves Effective for Jaguar Conservation?

    Directory of Open Access Journals (Sweden)

    Carmina E Gutiérrez-González

    Full Text Available We present the first study of density and apparent survival for a jaguar (Panthera onca population in northern Mexico using 13 years of camera trap data from 2000 to 2012. We used the Barker robust design model which combines data from closed sampling periods and resight data between these periods to estimate apparent survival and abundance. We identified 467 jaguar pictures that corresponded to 48 jaguar individuals. We included camera type and field technician as covariates for detection probabilities. We used three covariates to evaluate the effect of reserve on jaguar apparent survival: i private reserve creation ii later reserve expansions, and iii cattle ranches' conservation activities. We found that the use of digital cameras in addition to film cameras increased detection probability by a factor of 6x compared with the use of only film cameras (p = 0.34 ± 0.05 and p = 0.05 ± 0.02 respectively in the closed period and more than three times in the open period (R = 0.91 ± 0.08 and R = 0.30 ± 0.13 mixed and film cameras respectively. Our availability estimates showed no temporary emigration and a fidelity probability of 1. Despite an increase of apparent survival probability from 0.47 ± 0.15 to 0.56 ± 0.11 after 2007, no single covariate explained the change in these point estimates. Mean jaguar density was 1.87 ± 0.47 jaguars/100 km2. We found that 13 years of jaguar population monitoring with our sampling size were not enough for detecting changes in survival or density. Our results provide a baseline for studies evaluating the effectiveness of protected areas and the inclusion of ranch owners in jaguar conservation programs and long-term population viability.

  6. Federal Reserve System Semiannual Regulatory Agenda

    Science.gov (United States)

    2010-12-20

    ... [The Regulatory Plan and Unified Agenda of Federal Regulatory and Deregulatory Actions] [Federal Reserve System Semiannual Regulatory Agenda ] Part XXI Federal Reserve System Semiannual Regulatory Agenda... Flexibility Agenda AGENCY: Board of Governors of the Federal Reserve System. ACTION: Semiannual regulatory...

  7. Aberrant Signaling Pathways in Glioma

    International Nuclear Information System (INIS)

    Nakada, Mitsutoshi; Kita, Daisuke; Watanabe, Takuya; Hayashi, Yutaka; Teng, Lei; Pyko, Ilya V.; Hamada, Jun-Ichiro

    2011-01-01

    Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults; few treatments are available. Median survival rates range from 12–15 months. The biological characteristics of this tumor are exemplified by prominent proliferation, active invasiveness, and rich angiogenesis. This is mainly due to highly deregulated signaling pathways in the tumor. Studies of these signaling pathways have greatly increased our understanding of the biology and clinical behavior of GBM. An integrated view of signal transduction will provide a more useful approach in designing novel therapies for this devastating disease. In this review, we summarize the current understanding of GBM signaling pathways with a focus on potential molecular targets for anti-signaling molecular therapies

  8. Digital Signal Processing applied to Physical Signals

    CERN Document Server

    Alberto, Diego; Musa, L

    2011-01-01

    It is well known that many of the scientific and technological discoveries of the XXI century will depend on the capability of processing and understanding a huge quantity of data. With the advent of the digital era, a fully digital and automated treatment can be designed and performed. From data mining to data compression, from signal elaboration to noise reduction, a processing is essential to manage and enhance features of interest after every data acquisition (DAQ) session. In the near future, science will go towards interdisciplinary research. In this work there will be given an example of the application of signal processing to different fields of Physics from nuclear particle detectors to biomedical examinations. In Chapter 1 a brief description of the collaborations that allowed this thesis is given, together with a list of the publications co-produced by the author in these three years. The most important notations, definitions and acronyms used in the work are also provided. In Chapter 2, the last r...

  9. Computer derivation of some dolphin echolocation signals.

    Science.gov (United States)

    Altes, R A

    1971-09-03

    Recent advances in radar theory have given rise to a straightforward method of sonar signal design. The method involves computer maximization of a signal-to-interference ratio. The procedure has been used to derive sonar signals that can accurately measure target velocity. When two dolphins were placed in a situation conducive to the utilization of such signals, their waveforms were similar to those that had been theoretically derived.

  10. Subcellular Organization of GPCR Signaling.

    Science.gov (United States)

    Eichel, Kelsie; von Zastrow, Mark

    2018-02-01

    G protein-coupled receptors (GPCRs) comprise a large and diverse class of signal-transducing receptors that undergo dynamic and isoform-specific membrane trafficking. GPCRs thus have an inherent potential to initiate or regulate signaling reactions from multiple membrane locations. This review discusses emerging insights into the subcellular organization of GPCR function in mammalian cells, focusing on signaling transduced by heterotrimeric G proteins and β-arrestins. We summarize recent evidence indicating that GPCR-mediated activation of G proteins occurs not only from the plasma membrane (PM) but also from endosomes and Golgi membranes and that β-arrestin-dependent signaling can be transduced from the PM by β-arrestin trafficking to clathrin-coated pits (CCPs) after dissociation from a ligand-activated GPCR. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Intracellular signal modulation by nanomaterials.

    Science.gov (United States)

    Hussain, Salik; Garantziotis, Stavros; Rodrigues-Lima, Fernando; Dupret, Jean-Marie; Baeza-Squiban, Armelle; Boland, Sonja

    2014-01-01

    A thorough understanding of the interactions of nanomaterials with biological systems and the resulting activation of signal transduction pathways is essential for the development of safe and consumer friendly nanotechnology. Here we present an overview of signaling pathways induced by nanomaterial exposures and describe the possible correlation of their physicochemical characteristics with biological outcomes. In addition to the hierarchical oxidative stress model and a review of the intrinsic and cell-mediated mechanisms of reactive oxygen species (ROS) generating capacities of nanomaterials, we also discuss other oxidative stress dependent and independent cellular signaling pathways. Induction of the inflammasome, calcium signaling, and endoplasmic reticulum stress are reviewed. Furthermore, the uptake mechanisms can be of crucial importance for the cytotoxicity of nanomaterials and membrane-dependent signaling pathways have also been shown to be responsible for cellular effects of nanomaterials. Epigenetic regulation by nanomaterials, effects of nanoparticle-protein interactions on cell signaling pathways, and the induction of various cell death modalities by nanomaterials are described. We describe the common trigger mechanisms shared by various nanomaterials to induce cell death pathways and describe the interplay of different modalities in orchestrating the final outcome after nanomaterial exposures. A better understanding of signal modulations induced by nanomaterials is not only essential for the synthesis and design of safer nanomaterials but will also help to discover potential nanomedical applications of these materials. Several biomedical applications based on the different signaling pathways induced by nanomaterials are already proposed and will certainly gain a great deal of attraction in the near future.

  12. 24 CFR 891.605 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 891.605... 8 Assistance § 891.605 Replacement reserve. (a) Establishment of reserve. The Borrower shall establish and maintain a replacement reserve to aid in funding extraordinary maintenance, and repair and...

  13. 24 CFR 891.405 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 891.405....405 Replacement reserve. (a) Establishment of reserve. The Owner shall establish and maintain a replacement reserve to aid in funding extraordinary maintenance and repair and replacement of capital items...

  14. Cognitive Reserve: Implications for Assessment and Intervention

    OpenAIRE

    Stern, Yaakov

    2013-01-01

    The concept of reserve is used to explain the observation that some individuals function better than others in the presence of brain pathology. This paper reviews the concept of reserve from its theoretical basis to the implication of reserve for clinical practice. A distinction between brain reserve, referring to individual differences in the anatomic substrate, and cognitive reserve, referring to differences in the flexibility or adaptivity of cognitive networks, is useful. Epidemiologic ev...

  15. Plant peptide hormone signalling.

    Science.gov (United States)

    Motomitsu, Ayane; Sawa, Shinichiro; Ishida, Takashi

    2015-01-01

    The ligand-receptor-based cell-to-cell communication system is one of the most important molecular bases for the establishment of complex multicellular organisms. Plants have evolved highly complex intercellular communication systems. Historical studies have identified several molecules, designated phytohormones, that function in these processes. Recent advances in molecular biological analyses have identified phytohormone receptors and signalling mediators, and have led to the discovery of numerous peptide-based signalling molecules. Subsequent analyses have revealed the involvement in and contribution of these peptides to multiple aspects of the plant life cycle, including development and environmental responses, similar to the functions of canonical phytohormones. On the basis of this knowledge, the view that these peptide hormones are pivotal regulators in plants is becoming increasingly accepted. Peptide hormones are transcribed from the genome and translated into peptides. However, these peptides generally undergo further post-translational modifications to enable them to exert their function. Peptide hormones are expressed in and secreted from specific cells or tissues. Apoplastic peptides are perceived by specialized receptors that are located at the surface of target cells. Peptide hormone-receptor complexes activate intracellular signalling through downstream molecules, including kinases and transcription factors, which then trigger cellular events. In this chapter we provide a comprehensive summary of the biological functions of peptide hormones, focusing on how they mature and the ways in which they modulate plant functions. © 2015 Authors; published by Portland Press Limited.

  16. Optical Processing of High Dimensionality Signals

    DEFF Research Database (Denmark)

    Da Ros, Francesco

    signal processing, including wavelength conversion, optical phase conjugation (OPC), and signal regeneration. This project focuses precisely on the applications of OPAs for all-optical signal processing with a two-fold focus: on the one hand, processing the advanced modulation formats required......) waveguides, are investigated. The limits of parametric amplification for 16-quadrature amplitude modulation (QAM) signals are first characterized. The acquired knowledge is then applied to the design of a black-box OPC-device used to provide Kerr nonlinearity compensation for a 5-channel polarization......-division multiplexing (PDM) 16-QAM signal at 1.12 Tbps with significant improvements in received signal quality. Furthermore, the first demonstration of phase regeneration for binary phase-shift keying (BPSK) signals using the silicon platform is presented. The silicon-based OPA relies on a novel design where a reverse...

  17. Robust input design for nonlinear dynamic modeling of AUV.

    Science.gov (United States)

    Nouri, Nowrouz Mohammad; Valadi, Mehrdad

    2017-09-01

    Input design has a dominant role in developing the dynamic model of autonomous underwater vehicles (AUVs) through system identification. Optimal input design is the process of generating informative inputs that can be used to generate the good quality dynamic model of AUVs. In a problem with optimal input design, the desired input signal depends on the unknown system which is intended to be identified. In this paper, the input design approach which is robust to uncertainties in model parameters is used. The Bayesian robust design strategy is applied to design input signals for dynamic modeling of AUVs. The employed approach can design multiple inputs and apply constraints on an AUV system's inputs and outputs. Particle swarm optimization (PSO) is employed to solve the constraint robust optimization problem. The presented algorithm is used for designing the input signals for an AUV, and the estimate obtained by robust input design is compared with that of the optimal input design. According to the results, proposed input design can satisfy both robustness of constraints and optimality. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  18. Assessment of secondary aluminum reserves of nations

    DEFF Research Database (Denmark)

    Maung, Kyaw Nyunt; Yoshida, Tomoharu; Liu, Gang

    2017-01-01

    A classification framework of the secondary resources was applied to evaluate the framework's applicability and to assess secondary aluminum reserves for 19 countries. Estimated amounts of secondary aluminum reserves in 2010 were 85 million tonnes in the United States, 65 million tonnes in China......, 29 million tonnes in Japan, and 413 million tonnes globally. For the United States, its secondary reserves are larger than its primary reserves, although the global primary reserves (28,000 million tonnes) are much larger than the estimated secondary reserves. Considerable amounts of secondary...

  19. Metabolic reserve as a determinant of cognitive aging.

    Science.gov (United States)

    Stranahan, Alexis M; Mattson, Mark P

    2012-01-01

    Mild cognitive impairment (MCI) and Alzheimer's disease (AD) represent points on a continuum of cognitive performance in aged populations. Cognition may be impaired or preserved in the context of brain aging. One theory to account for memory maintenance in the context of extensive pathology involves 'cognitive reserve', or the ability to compensate for neuropathology through greater recruitment of remaining neurons. In this review, we propose a complementary hypothesis of 'metabolic reserve', where a brain with high metabolic reserve is characterized by the presence of neuronal circuits that respond adaptively to perturbations in cellular and somatic energy metabolism and thereby protects against declining cognition. Lifestyle determinants of metabolic reserve, such as exercise, reduced caloric intake, and intake of specific dietary components can promote neuroprotection, while pathological states arising from sedentary lifestyles and excessive caloric intake contribute to neuronal endangerment. This bidirectional relationship between metabolism and cognition may be mediated by alterations in central insulin and neurotrophic factor signaling and glucose metabolism, with downstream consequences for accumulation of amyloid-β and hyperphosphorylated tau. The metabolic reserve hypothesis is supported by epidemiological findings and the spectrum of individual cognitive trajectories during aging, with additional data from animal models identifying potential mechanisms for this relationship. Identification of biomarkers for metabolic reserve could assist in generating a predictive model for the likelihood of cognitive decline with aging.

  20. Canonical Wnt signaling in diabetic retinopathy.

    Science.gov (United States)

    Chen, Qian; Ma, Jian-Xing

    2017-10-01

    Diabetic retinopathy (DR) is a common eye complication of diabetes, and the pathogenic mechanism of DR is still under investigation. The canonical Wnt signaling pathway is an evolutionarily conserved pathway that plays fundamental roles in embryogenesis and adult tissue homeostasis. Wnt signaling regulates expression of multiple genes that control retinal development and eye organogenesis, and dysregulated Wnt signaling plays pathophysiological roles in many ocular diseases, including DR. This review highlights recent progress in studies of Wnt signaling in DR. We discuss Wnt signaling regulation in the retina and dysregulation of Wnt signaling associated with ocular diseases with an emphasis on DR. We also discuss the therapeutic potential of modulating Wnt signaling in DR. Continued studies in this field will advance our current understanding on DR and contribute to the development of new treatments. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Digital storage of repeated signals

    International Nuclear Information System (INIS)

    Prozorov, S.P.

    1984-01-01

    An independent digital storage system designed for repeated signal discrimination from background noises is described. The signal averaging is performed off-line in the real time mode by means of multiple selection of the investigated signal and integration in each point. Digital values are added in a simple summator and the result is recorded the storage device with the volume of 1024X20 bit from where it can be output on an oscillograph, a plotter or transmitted to a compUter for subsequent processing. The described storage is reliable and simple device on one base of which the systems for the nuclear magnetic resonapce signal acquisition in different experiments are developed

  2. Metabolites in vertebrate Hedgehog signaling.

    Science.gov (United States)

    Roberg-Larsen, Hanne; Strand, Martin Frank; Krauss, Stefan; Wilson, Steven Ray

    2014-04-11

    The Hedgehog (HH) signaling pathway is critical in embryonic development, stem cell biology, tissue homeostasis, chemoattraction and synapse formation. Irregular HH signaling is associated with a number of disease conditions including congenital disorders and cancer. In particular, deregulation of HH signaling has been linked to skin, brain, lung, colon and pancreatic cancers. Key mediators of the HH signaling pathway are the 12-pass membrane protein Patched (PTC), the 7-pass membrane protein Smoothened (SMO) and the GLI transcription factors. PTC shares homology with the RND family of small-molecule transporters and it has been proposed that it interferes with SMO through metabolites. Although a conclusive picture is lacking, substantial efforts are made to identify and understand natural metabolites/sterols, including cholesterol, vitamin D3, oxysterols and glucocorticoides, that may be affected by, or influence the HH signaling cascade at the level of PTC and SMO. In this review we will elaborate the role of metabolites in HH signaling with a focus on oxysterols, and discuss advancements in modern analytical approaches in the field. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Cognitive Reserve: Implications for Assessment and Intervention

    Science.gov (United States)

    Stern, Yaakov

    2014-01-01

    The concept of reserve is used to explain the observation that some individuals function better than others in the presence of brain pathology. This paper reviews the concept of reserve from its theoretical basis to the implication of reserve for clinical practice. A distinction between brain reserve, referring to individual differences in the anatomic substrate, and cognitive reserve, referring to differences in the flexibility or adaptivity of cognitive networks, is useful. Epidemiologic evidence indicates that a set of life exposures including higher educational and occupational attainment, and engaging in leisure activities is associated with a lower risk of incident dementia, suggesting that these life exposures may enhance cognitive reserve. This provides a basis for controlled clinical studies can test specific exposures that may enhance reserve. The concept of cognitive reserve also has important implications for clinical practice in terms of diagnosis and prognosis. PMID:23941972

  4. Clipboard: Unraveling the mystery of cognitive reserve

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 40; Issue 2. Clipboard : Unraveling the mystery of cognitive reserve ... Keywords. Aging; Alzheimer's; bilingualism; cognitive reserve; dementia; Down's; education; enrichment; environment; learning; long term potentiation; LTP; memory; neuroepigenetics; plasticity ...

  5. Transforming the Reserve Component: Four Essays

    National Research Council Canada - National Science Library

    Binnendijk, Hans; Baranick, Michael J; Bell, Raymond E., Jr; Cordero, Gina; Duncan, Stephen M; Holshek, Christopher; Wentz, Larry

    2005-01-01

    This volume contains four essays on various aspects of the Reserve Component. We publish it at a time when Reserves are serving overseas at historically high rates and when new missions like homeland security demand their attention...

  6. 5 CFR 330.610 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false [Reserved] 330.610 Section 330.610 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND... Employees § 330.610 [Reserved] ...

  7. 5 CFR 330.603 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false [Reserved] 330.603 Section 330.603 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND... Employees § 330.603 [Reserved] ...

  8. Astrocytes in endocannabinoid signalling.

    Science.gov (United States)

    Navarrete, Marta; Díez, Adolfo; Araque, Alfonso

    2014-10-19

    Astrocytes are emerging as integral functional components of synapses, responding to synaptically released neurotransmitters and regulating synaptic transmission and plasticity. Thus, they functionally interact with neurons establishing tripartite synapses: a functional concept that refers to the existence of communication between astrocytes and neurons and its crucial role in synaptic function. Here, we discuss recent evidence showing that astrocytes are involved in the endocannabinoid (ECB) system, responding to exogenous cannabinoids as well as ECBs through activation of type 1 cannabinoid receptors, which increase intracellular calcium and stimulate the release of glutamate that modulates synaptic transmission and plasticity. We also discuss the consequences of ECB signalling in tripartite synapses on the astrocyte-mediated regulation of synaptic function, which reveal novel properties of synaptic regulation by ECBs, such as the spatially controlled dual effect on synaptic strength and the lateral potentiation of synaptic efficacy. Finally, we discuss the potential implications of ECB signalling for astrocytes in brain pathology and animal behaviour. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  9. Reserving by detailed conditioning on individual claim

    Science.gov (United States)

    Kartikasari, Mujiati Dwi; Effendie, Adhitya Ronnie; Wilandari, Yuciana

    2017-03-01

    The estimation of claim reserves is an important activity in insurance companies to fulfill their liabilities. Recently, reserving method of individual claim have attracted a lot of interest in the actuarial science, which overcome some deficiency of aggregated claim method. This paper explores the Reserving by Detailed Conditioning (RDC) method using all of claim information for reserving with individual claim of liability insurance from an Indonesian general insurance company. Furthermore, we compare it to Chain Ladder and Bornhuetter-Ferguson method.

  10. Poverty and corruption compromise tropical forest reserves.

    Science.gov (United States)

    Wright, S Joseph; Sanchez-Azofeifa, G Arturo; Portillo-Quintero, Carlos; Davies, Diane

    2007-07-01

    We used the global fire detection record provided by the satellite-based Moderate Resolution Imaging Spectroradiometer (MODIS) to determine the number of fires detected inside 823 tropical and subtropical moist forest reserves and for contiguous buffer areas 5, 10, and 15 km wide. The ratio of fire detection densities (detections per square kilometer) inside reserves to their contiguous buffer areas provided an index of reserve effectiveness. Fire detection density was significantly lower inside reserves than in paired, contiguous buffer areas but varied by five orders of magnitude among reserves. The buffer: reserve detection ratio varied by up to four orders of magnitude among reserves within a single country, and median values varied by three orders of magnitude among countries. Reserves tended to be least effective at reducing fire frequency in many poorer countries and in countries beset by corruption. Countries with the most successful reserves include Costa Rica, Jamaica, Malaysia, and Taiwan and the Indonesian island of Java. Countries with the most problematic reserves include Cambodia, Guatemala, Paraguay, and Sierra Leone and the Indonesian portion of Borneo. We provide fire detection density for 3964 tropical and subtropical reserves and their buffer areas in the hope that these data will expedite further analyses that might lead to improved management of tropical reserves.

  11. 24 CFR 572.125 - Replacement reserves.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Replacement reserves. 572.125...) Homeownership Program Requirements-Implementation Grants § 572.125 Replacement reserves. (a) Purpose. A single replacement reserve may be established for the homeownership program only if HUD determines it is necessary to...

  12. 24 CFR 880.602 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 880.602... Replacement reserve. (a) A replacement reserve must be established and maintained in an interest-bearing account to aid in funding extraordinary maintenance and repair and replacement of capital items. (1) Part...

  13. 24 CFR 891.745 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 891.745... and Individuals-Section 162 Assistance § 891.745 Replacement reserve. The general requirements for the replacement reserve are provided in § 891.605. For projects funded under §§ 891.655 through 891.790, the...

  14. Reserve evaluation of minerals at NUCLEBRAS

    International Nuclear Information System (INIS)

    Marques, J.P.M.; Guerra, P.A.G.; Vinha, C.A.G. da

    1980-10-01

    The method used for the reserve evaluation of minerals, particularly of uranium, as used worldwide, and specially at NUCLEBRAS is described. This is done through a series of procedures envolving basic definitions, reserve evaluation methods (conventional, statistical and geoestatistical), data management, use of computer systems, classification and evaluation of reserves. (Author) [pt

  15. John Brainerd and the First Indian Reservation.

    Science.gov (United States)

    Harper, Susanne Banta

    1979-01-01

    Describes the humanitarian founding in 1758 of the nation's first reservation--the Brotherton reservation for New Jersey's Lenni Lenape (Algonquin) Indians. The people were demoralized, sick, and decimated in numbers; and so the venture failed. In 1801 those few remaining sold the reservation and moved to join related tribes in New York. (DS)

  16. Using music as a signal for biofeedback.

    Science.gov (United States)

    Bergstrom, Ilias; Seinfeld, Sofia; Arroyo-Palacios, Jorge; Slater, Mel; Sanchez-Vives, Maria V

    2014-07-01

    Studies on the potential benefits of conveying biofeedback stimulus using a musical signal have appeared in recent years with the intent of harnessing the strong effects that music listening may have on subjects. While results are encouraging, the fundamental question has yet to be addressed, of how combined music and biofeedback compares to the already established use of either of these elements separately. This experiment, involving young adults (N = 24), compared the effectiveness at modulating participants' states of physiological arousal of each of the following conditions: A) listening to pre-recorded music, B) sonification biofeedback of the heart rate, and C) an algorithmically modulated musical feedback signal conveying the subject's heart rate. Our hypothesis was that each of the conditions (A), (B) and (C) would differ from the other two in the extent to which it enables participants to increase and decrease their state of physiological arousal, with (C) being more effective than (B), and both more than (A). Several physiological measures and qualitative responses were recorded and analyzed. Results show that using musical biofeedback allowed participants to modulate their state of physiological arousal at least equally well as sonification biofeedback, and much better than just listening to music, as reflected in their heart rate measurements, controlling for respiration-rate. Our findings indicate that the known effects of music in modulating arousal can therefore be beneficially harnessed when designing a biofeedback protocol. Copyright © 2013 Elsevier B.V. All rights reserved.

  17. 4-hydroxynonenal-mediated signaling and aging.

    Science.gov (United States)

    Zhang, Hongqiao; Forman, Henry Jay

    2017-10-01

    4-Hydroxy-2-nonenal (HNE), one of the major α, β-unsaturated aldehydes produced during lipid peroxidation, is a potent messenger in mediating signaling pathways. Lipid peroxidation and HNE production appear to increase with aging. Although the cause and effect relation remains arguable, aging is associated with significant changes in diverse signaling events, characterized by enhanced or diminished responses of specific signaling pathways. In this review we will discuss how HNE may contribute to aging-related alterations of signaling pathways. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Basic digital signal processing

    CERN Document Server

    Lockhart, Gordon B

    1985-01-01

    Basic Digital Signal Processing describes the principles of digital signal processing and experiments with BASIC programs involving the fast Fourier theorem (FFT). The book reviews the fundamentals of the BASIC program, continuous and discrete time signals including analog signals, Fourier analysis, discrete Fourier transform, signal energy, power. The text also explains digital signal processing involving digital filters, linear time-variant systems, discrete time unit impulse, discrete-time convolution, and the alternative structure for second order infinite impulse response (IIR) sections.

  19. Hedgehog signaling in the stomach.

    Science.gov (United States)

    Konstantinou, Daniel; Bertaux-Skeirik, Nina; Zavros, Yana

    2016-12-01

    The Hedgehog (Hh) signaling pathway not only plays a key part in controlling embryonic development, but in the adult stomach governs important cellular events such as epithelial cell differentiation, proliferation, gastric disease, and regeneration. In particular, Sonic Hedgehog (Shh) signaling has been well studied for its role in gastric physiology and pathophysiology. Shh is secreted from the gastric parietal cells and contributes to the regeneration of the epithelium in response to injury, or the development of gastritis during Helicobacter pylori infection. Dysregulation of the Shh signaling pathway leads to the disruption of gastric differentiation, loss of gastric acid secretion and the development of cancer. In this chapter, we will review the most recent findings that reveal the role of Shh as a regulator of gastric physiology, regeneration, and disease. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Cognitive reserve in ageing and Alzheimer's disease

    Science.gov (United States)

    Stern, Yaakov

    2012-01-01

    The concept of reserve accounts for individual differences in susceptibility to age-related brain changes or Alzheimer's disease-related pathology. There is evidence that some people can tolerate more of these changes than others and still maintain function. Epidemiologic studies suggest that lifetime exposures including educational and occupational attainment, and leisure activities in late life, can increase this reserve. For example, there is a reduced risk of developing Alzheimer's disease in individuals with higher educational or occupational attainment. It is convenient to think of two types of reserve: brain reserve, which refers to actual differences in the brain itself that may increase tolerance of pathology, and cognitive reserve. Cognitive reserve refers to individual differences in how tasks are performed that may allow some people to be more resilient than others. The concept of cognitive reserve holds out the promise of interventions that could slow cognitive aging or reduce the risk of dementia. PMID:23079557

  1. The mixed block/event-related design.

    Science.gov (United States)

    Petersen, Steven E; Dubis, Joseph W

    2012-08-15

    Neuroimaging studies began using block design and event-related design experiments. While providing many insights into brain functions, these fMRI design types ignore components of the BOLD signal that can teach us additional elements. The development of the mixed block/event-related fMRI design allowed for a fuller characterization of nonlinear and time-sensitive neuronal responses: for example, the interaction between block and event related factors and the simultaneous extraction of transient activity related to trials and block transitions and sustained activity related to task-level processing. This review traces the origins of the mixed block/event-related design from conceptual precursors to a seminal paper and on to subsequent studies using the method. The review also comments on aspects of the experimental design that must be considered when attempting to use the mixed block/event-related design. When taking into account these considerations, the mixed block/event-related design allows fuller utilization of the BOLD signal allowing deeper interpretation of how regions of the brain function on multiple timescales. Copyright © 2011 Elsevier Inc. All rights reserved.

  2. Bat diversity and abundance in Omo Forest Reserve, Nigeria ...

    African Journals Online (AJOL)

    Bats are yet to be incorporated in management plans in Nigeria. This is attributed to dearth in information as well as social stigma. This study was designed to determine bat species diversity, abundance and the relation of both indices to habitat structure. The survey was carried out in Omo forest reserve between May and ...

  3. Individual loss reserving with the Multivariate Skew Normal distribution

    NARCIS (Netherlands)

    Pigeon, M.; Antonio, K.; Denuit, M.

    2012-01-01

    The evaluation of future cash flows and solvency capital recently gained importance in general insurance. To assist in this process, our paper proposes a novel loss reserving model, designed for individual claims in discrete time. We model the occurrence of claims, as well as their reporting delay,

  4. Individual loss reserving using paid-incurred data

    NARCIS (Netherlands)

    Pigeon, M.; Antonio, K.; Denuit, M.

    2014-01-01

    This paper develops a stochastic model for individual claims reserving using observed data on claim payments as well as incurred losses. We extend the approach of Pigeon et al. (2013), designed for payments only, towards the inclusion of incurred losses. We call the new technique the individual Paid

  5. Individual loss reserving with the multivariate skew normal framework

    NARCIS (Netherlands)

    Pigeon, M.; Antonio, K.; Denuit, M.

    2013-01-01

    The evaluation of future cash flows and solvency capital recently gained importance in general insurance. To assist in this process, our paper proposes a novel loss reserving model, designed for individual claims developing in discrete time. We model the occurrence of claims, as well as their

  6. Effect of structure on sensing performance of a target induced signaling probe shifting DNA-based (TISPS-DNA) sensor.

    Science.gov (United States)

    Yu, Xiang; Yu, Zhigang; Li, Fengqin; Xu, Yanmei; He, Xunjun; Xu, Lan; Shi, Wenbing; Zhang, Guiling; Yan, Hong

    2017-05-15

    A type of "signal on" displacement-based sensors named target induced signaling probe shifting DNA-based (TISPS-DNA) sensor were developed for a designated DNA detection. The signaling mechanism of the signaling probe (SP) shifting different from the classical conformation/flexibility change mode endows the sensor with high sensitivity. Through using thiolated or no thiolated capturing probe (CP), two 3-probe sensing structures, sensor-1 and sensor-2, were designed and constructed. The systematical comparing research results show that both sensors exhibit some similarities or big differences in sensing performance. On the one hand, the similarity in structures determines the similarity in some aspects of signaling mechanism, background signal, signal changing form, anti-fouling ability and versatility; on the other hand, the slight difference in structures also results in two opposite hybridization modes of gradual increasing resistance and gradual decreasing resistance which can affect the hybridization efficiency between the assistant probe (AP) and the SP, further producing some big differences in sensing performance, for example, apparently different signal enhancement (SE) change, point mutation discrimination ability and response speed. Under the optimized fabrication and detection conditions, both sensors feature high sensitivity for target DNAs with the detection limits of ∼10 fM for sensor-1 and ∼7 fM for sensor-2, respectively. Among many acquired sensing virtues, the sensor-1 shows a peculiar specificity adjustability which is also a highlight in this work. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. The development of the International Network for Frontier Research on Earthquake Precursors (INFREP) by designing new analysing software and by setting up new recording locations of radio VLF/LF signals in Romania

    Science.gov (United States)

    Moldovan, Iren-Adelina; Petruta Constantin, Angela; Emilian Toader, Victorin; Toma-Danila, Dragos; Biagi, Pier Francesco; Maggipinto, Tommaso; Dolea, Paul; Septimiu Moldovan, Adrian

    2014-05-01

    we have realized the automation of the transfer, storage and initial processing of data using the LabView software platform. The special designed LabVIEW application, which accesses the VLF/LF receiver through internet, opens the receiver's web-page and automatically retrieves the list of data files to synchronize the user-side data with the receiver's data. Missing zipped files are also automatically downloaded. The application performs primary, statistical correlation and spectral analysis, appends daily files into monthly and annual files and performs 3D color-coded maps with graphic representations of VLF and LF signals' intensities versus the minute-of-the-day and the day-of-the-month, facilitating a near real-time observation of VLF and LF electromagnetic waves' propagation. Another feature of the software is the correlation of the daily recorded files for the studied frequencies by overlaying the 24 hours radio activity and taking into account the sunrise and sunset. The next step in developing the Romanian EM recording system is to enlarge the INFREP network with new VLF/LF receivers for a better coverage and separation of European seismogenic zones. This will be done in the future by using national resources. The unitary seismotectonic zoning of Romania and the whole Europe is a very important step for this goal.

  8. Modified BTC Algorithm for Audio Signal Coding

    Directory of Open Access Journals (Sweden)

    TOMIC, S.

    2016-11-01

    Full Text Available This paper describes modification of a well-known image coding algorithm, named Block Truncation Coding (BTC and its application in audio signal coding. BTC algorithm was originally designed for black and white image coding. Since black and white images and audio signals have different statistical characteristics, the application of this image coding algorithm to audio signal presents a novelty and a challenge. Several implementation modifications are described in this paper, while the original idea of the algorithm is preserved. The main modifications are performed in the area of signal quantization, by designing more adequate quantizers for audio signal processing. The result is a novel audio coding algorithm, whose performance is presented and analyzed in this research. The performance analysis indicates that this novel algorithm can be successfully applied in audio signal coding.

  9. Demand for International Reserves in Turkey

    Directory of Open Access Journals (Sweden)

    Yimaz Sinem

    2014-06-01

    Full Text Available Having an important place in the international monetary system, international reserves held by central bank usually reflect country’s economic strength in terms of international finance and trade. There are many reasons for holding international reserves by central banks such as financing the deficit in the balance of payment, managing the monetary and exchange rate policies, minimizing the negative effects of external shocks and reducing the cost of borrowing. Continuously changing and diversifying characteristics of these reasons affect the demand for reserves depending to the economic conditions of the country. Over the last ten years, there has been a tremendous increase in international reserves held by Turkish Central Bank. From 2002 to 2012, the reserves of the bank have risen from 20 billion dollars to 96 billion dollars, showing an increase more than four times. This sudden and huge increase in the foreign reserves drove us to determine and investigate the factors which induce the Turkish Central Bank to hold high level of reserves. Thus, the purpose of this study is to estimate and analyze the demand for international reserves held by central banks using the buffer stock model in the case of Turkey. The data used in the study is monthly and cover the period of 1990:03-2012:10. The buffer stock model was econometrically estimated by using the OLS method for three different models. Our findings indicate that the opportunity cost affected reserve demand much stronger than the reserve volatility in Turkish case.

  10. Naval Petroleum and Oil Shale Reserves

    International Nuclear Information System (INIS)

    1992-01-01

    During fiscal year 1992, the reserves generated $473 million in revenues, a $181 million decrease from the fiscal year 1991 revenues, primarily due to significant decreases in oil and natural gas prices. Total costs were $200 million, resulting in net cash flow of $273 million, compared with $454 million in fiscal year 1991. From 1976 through fiscal year 1992, the Naval Petroleum and Oil Shale Reserves generated more than $15 billion in revenues and a net operating income after costs of $12.5 billion. In fiscal year 1992, production at the Naval Petroleum Reserves at maximum efficient rates yielded 26 million barrels of crude oil, 119 billion cubic feet of natural gas, and 164 million gallons of natural gas liquids. From April to November 1992, senior managers from the Naval Petroleum and Oil Shale Reserves held a series of three workshops in Boulder, Colorado, in order to build a comprehensive Strategic Plan as required by Secretary of Energy Notice 25A-91. Other highlights are presented for the following: Naval Petroleum Reserve No. 1--production achievements, crude oil shipments to the strategic petroleum reserve, horizontal drilling, shallow oil zone gas injection project, environment and safety, and vanpool program; Naval Petroleum Reserve No. 2--new management and operating contractor and exploration drilling; Naval Petroleum Reserve No. 3--steamflood; Naval Oil Shale Reserves--protection program; and Tiger Team environmental assessment of the Naval Petroleum and Oil Shale Reserves in Colorado, Utah, and Wyoming

  11. Pseudo random signal processing theory and application

    CERN Document Server

    Zepernick, Hans-Jurgen

    2013-01-01

    In recent years, pseudo random signal processing has proven to be a critical enabler of modern communication, information, security and measurement systems. The signal's pseudo random, noise-like properties make it vitally important as a tool for protecting against interference, alleviating multipath propagation and allowing the potential of sharing bandwidth with other users. Taking a practical approach to the topic, this text provides a comprehensive and systematic guide to understanding and using pseudo random signals. Covering theoretical principles, design methodologies and applications

  12. A General Business Model for Marine Reserves

    Science.gov (United States)

    Sala, Enric; Costello, Christopher; Dougherty, Dawn; Heal, Geoffrey; Kelleher, Kieran; Murray, Jason H.; Rosenberg, Andrew A.; Sumaila, Rashid

    2013-01-01

    Marine reserves are an effective tool for protecting biodiversity locally, with potential economic benefits including enhancement of local fisheries, increased tourism, and maintenance of ecosystem services. However, fishing communities often fear short-term income losses associated with closures, and thus may oppose marine reserves. Here we review empirical data and develop bioeconomic models to show that the value of marine reserves (enhanced adjacent fishing + tourism) may often exceed the pre-reserve value, and that economic benefits can offset the costs in as little as five years. These results suggest the need for a new business model for creating and managing reserves, which could pay for themselves and turn a profit for stakeholder groups. Our model could be expanded to include ecosystem services and other benefits, and it provides a general framework to estimate costs and benefits of reserves and to develop such business models. PMID:23573192

  13. Substantiating the Incurred but not Reported Reserve

    Directory of Open Access Journals (Sweden)

    Georgeta Vintilã

    2009-12-01

    Full Text Available In order to handle past and future liability taken by insurance contracts concluded, any insurance company must constitute and maintain technical reserves. Substantiating technical reserves is done through actuarial methods and its over-evaluation or under-evaluation influence solvency and financial performance of the insurance companies, in the sense of reducing solvency through over-evaluating reserves and, respectively, influencing profit (hence of outstanding tax through under-evaluating reserves. An important reserve for insurance companies is represented by the incurred but not reported reserve, as it allows the estimation of the liability the company may confront in the future, generated by events occurred in the past, which are not currently known in the present but will be reported in the future.

  14. IGT calculates world reserves of fossil fuels

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    The Institute of Gas Technology has published the IGT World Reserves Survey, giving their latest tabulation of world reserves of fossil fuels and uranium. The report contains 120 Tables and 41 Figures. Estimates are provided for proved reserves, resources, current production, and life indexes of the non-renewable energy sources of the US and of the world as a whole. World regional data are also provided in many cases. The data are summarized here. 2 figures, 5 tables

  15. Reserve valuation in electric power systems

    Science.gov (United States)

    Ruiz, Pablo Ariel

    Operational reliability is provided in part by scheduling capacity in excess of the load forecast. This reserve capacity balances the uncertain power demand with the supply in real time and provides for equipment outages. Traditionally, reserve scheduling has been ensured by enforcing reserve requirements in the operations planning. An alternate approach is to employ a stochastic formulation, which allows the explicit modeling of the sources of uncertainty. This thesis compares stochastic and reserve methods and evaluates the benefits of a combined approach for the efficient management of uncertainty in the unit commitment problem. Numerical studies show that the unit commitment solutions obtained for the combined approach are robust and superior with respect to the traditional approach. These robust solutions are especially valuable in areas with a high proportion of wind power, as their built-in flexibility allows the dispatch of practically all the available wind power while minimizing the costs of operation. The scheduled reserve has an economic value since it reduces the outage costs. In several electricity markets, reserve demand functions have been implemented to take into account the value of reserve in the market clearing process. These often take the form of a step-down function at the reserve requirement level, and as such they may not appropriately represent the reserve value. The value of reserve is impacted by the reliability, dynamic and stochastic characteristics of system components, the system operation policies, and the economic aspects such as the risk preferences of the demand. In this thesis, these aspects are taken into account to approximate the reserve value and construct reserve demand functions. Illustrative examples show that the demand functions constructed have similarities with those implemented in some markets.

  16. Reserve reporting from a banker's perspective

    International Nuclear Information System (INIS)

    Larson, B.O.

    1996-01-01

    A banker's perspective of oil and gas reserve reporting was presented. Topics chosen for discussion emphasized oil and gas lending, and the type of capital which is most relevant to the oil and gas industry. The concept of capital differentiation, potential worst case, and least specialization, were explained. An explanation of the reasons for the lender's different perspective on reserves was given. Methods that banks use to limit risk, and the role that reserve reports play in loan approvals were also reviewed

  17. Simulated evolution of signal transduction networks.

    Directory of Open Access Journals (Sweden)

    Mohammad Mobashir

    Full Text Available Signal transduction is the process of routing information inside cells when receiving stimuli from their environment that modulate the behavior and function. In such biological processes, the receptors, after receiving the corresponding signals, activate a number of biomolecules which eventually transduce the signal to the nucleus. The main objective of our work is to develop a theoretical approach which will help to better understand the behavior of signal transduction networks due to changes in kinetic parameters and network topology. By using an evolutionary algorithm, we designed a mathematical model which performs basic signaling tasks similar to the signaling process of living cells. We use a simple dynamical model of signaling networks of interacting proteins and their complexes. We study the evolution of signaling networks described by mass-action kinetics. The fitness of the networks is determined by the number of signals detected out of a series of signals with varying strength. The mutations include changes in the reaction rate and network topology. We found that stronger interactions and addition of new nodes lead to improved evolved responses. The strength of the signal does not play any role in determining the response type. This model will help to understand the dynamic behavior of the proteins involved in signaling pathways. It will also help to understand the robustness of the kinetics of the output response upon changes in the rate of reactions and the topology of the network.

  18. 1979 Reserve Force Studies Surveys: Survey Design, Sample Design and Administrative Procedures,

    Science.gov (United States)

    1981-08-01

    Dental Service 17 Reception Cnt. 11Other 46 Total 2914 The heterogeneity of the units poses a problem for a unit sampling plan. Namely, if the...regular schoel or collae 04. What is tha ZIP Code ZIP Cods thats you think you will ama c0oMsil In tha futura? If af tha placa whare your highest grade

  19. When will fossil fuel reserves be diminished?

    International Nuclear Information System (INIS)

    Shafiee, Shahriar; Topal, Erkan

    2009-01-01

    Crude oil, coal and gas are the main resources for world energy supply. The size of fossil fuel reserves and the dilemma that 'when non-renewable energy will be diminished' is a fundamental and doubtful question that needs to be answered. This paper presents a new formula for calculating when fossil fuel reserves are likely to be depleted and develops an econometrics model to demonstrate the relationship between fossil fuel reserves and some main variables. The new formula is modified from the Klass model and thus assumes a continuous compound rate and computes fossil fuel reserve depletion times for oil, coal and gas of approximately 35, 107 and 37 years, respectively. This means that coal reserves are available up to 2112, and will be the only fossil fuel remaining after 2042. In the Econometrics model, the main exogenous variables affecting oil, coal and gas reserve trends are their consumption and respective prices between 1980 and 2006. The models for oil and gas reserves unexpectedly show a positive and significant relationship with consumption, while presenting a negative and significant relationship with price. The econometrics model for coal reserves, however, expectedly illustrates a negative and significant relationship with consumption and a positive and significant relationship with price. Consequently, huge reserves of coal and low-level coal prices in comparison to oil and gas make coal one of the main energy substitutions for oil and gas in the future, under the assumption of coal as a clean energy source. (author)

  20. Reservation system with graphical user interface

    KAUST Repository

    Mohamed, Mahmoud A. Abdelhamid

    2012-01-05

    Techniques for providing a reservation system are provided. The techniques include displaying a scalable visualization object, wherein the scalable visualization object comprises an expanded view element of the reservation system depicting information in connection with a selected interval of time and a compressed view element of the reservation system depicting information in connection with one or more additional intervals of time, maintaining a visual context between the expanded view and the compressed view within the visualization object, and enabling a user to switch between the expanded view and the compressed view to facilitate use of the reservation system.

  1. Signal Processing and Restoration

    NARCIS (Netherlands)

    Biemond, J.; Slump, C.H.; Lagendijk, R.L.; Tolhuizen, L.M.G.M.; de With, P.H.N.

    2004-01-01

    Digital Signal Processing (DSP) concerns the theoretical and practical aspects of representing information-bearing signals in digital form and the use of processors or special purpose hardware to extract that information or to transform the signals in useful ways. Areas where digital signal

  2. Retroactive signaling in short signaling pathways.

    Directory of Open Access Journals (Sweden)

    Jacques-Alexandre Sepulchre

    Full Text Available In biochemical signaling pathways without explicit feedback connections, the core signal transduction is usually described as a one-way communication, going from upstream to downstream in a feedforward chain or network of covalent modification cycles. In this paper we explore the possibility of a new type of signaling called retroactive signaling, offered by the recently demonstrated property of retroactivity in signaling cascades. The possibility of retroactive signaling is analysed in the simplest case of the stationary states of a bicyclic cascade of signaling cycles. In this case, we work out the conditions for which variables of the upstream cycle are affected by a change of the total amount of protein in the downstream cycle, or by a variation of the phosphatase deactivating the same protein. Particularly, we predict the characteristic ranges of the downstream protein, or of the downstream phosphatase, for which a retroactive effect can be observed on the upstream cycle variables. Next, we extend the possibility of retroactive signaling in short but nonlinear signaling pathways involving a few covalent modification cycles.

  3. Signal verification can promote reliable signalling.

    Science.gov (United States)

    Broom, Mark; Ruxton, Graeme D; Schaefer, H Martin

    2013-11-22

    The central question in communication theory is whether communication is reliable, and if so, which mechanisms select for reliability. The primary approach in the past has been to attribute reliability to strategic costs associated with signalling as predicted by the handicap principle. Yet, reliability can arise through other mechanisms, such as signal verification; but the theoretical understanding of such mechanisms has received relatively little attention. Here, we model whether verification can lead to reliability in repeated interactions that typically characterize mutualisms. Specifically, we model whether fruit consumers that discriminate among poor- and good-quality fruits within a population can select for reliable fruit signals. In our model, plants either signal or they do not; costs associated with signalling are fixed and independent of plant quality. We find parameter combinations where discriminating fruit consumers can select for signal reliability by abandoning unprofitable plants more quickly. This self-serving behaviour imposes costs upon plants as a by-product, rendering it unprofitable for unrewarding plants to signal. Thus, strategic costs to signalling are not a prerequisite for reliable communication. We expect verification to more generally explain signal reliability in repeated consumer-resource interactions that typify mutualisms but also in antagonistic interactions such as mimicry and aposematism.

  4. Multichannel Coding of Applause Signals

    OpenAIRE

    Jeroen Breebaart; Steven van de Par; Gerard Hotho

    2007-01-01

    We develop a parametric multichannel audio codec dedicated to coding signals consisting of a dense series of transient-type events. These signals of which applause is a typical example are known to be problematic for such audio codecs. The codec design is based on preservation of both timbre and transient-type event density. It combines a very low complexity and a low parameter bit rate (0.2 kbps). In a formal listening test, we compared the proposed codec to the recently standardised MPEG Su...

  5. Advanced Traffic Signal Control Algorithms Phase II

    Science.gov (United States)

    2015-12-15

    The goal of the project was to design and implement an in-vehicle system that calculates and provide speed advice to the driver of the vehicle, using Signal Phase and Timing (SPaT) and Geometric Information Description (GID) information of the signal...

  6. RET Signaling in Prostate Cancer.

    Science.gov (United States)

    Ban, Kechen; Feng, Shu; Shao, Longjiang; Ittmann, Michael

    2017-08-15

    Purpose: Large diameter perineural prostate cancer is associated with poor outcomes. GDNF, with its coreceptor GFRα1, binds RET and activates downstream pro-oncogenic signaling. Because both GDNF and GFRα1 are secreted by nerves, we examined the role of RET signaling in prostate cancer. Experimental Design: Expression of RET, GDNF, and/or GFRα1 was assessed. The impact of RET signaling on proliferation, invasion and soft agar colony formation, perineural invasion, and growth in vivo was determined. Cellular signaling downstream of RET was examined by Western blotting. Results: RET is expressed in all prostate cancer cell lines. GFRα1 is only expressed in 22Rv1 cells, which is the only line that responds to exogenous GDNF. In contrast, all cell lines respond to GDNF plus GFRα1. Conditioned medium from dorsal root ganglia contains secreted GFRα1 and promotes transformation-related phenotypes, which can be blocked by anti-GFRα1 antibody. Perineural invasion in the dorsal root ganglion assay is inhibited by anti-GFRα antibody and RET knockdown. In vivo , knockdown of RET inhibits tumor growth. RET signaling activates ERK or AKT signaling depending on context, but phosphorylation of p70S6 kinase is markedly increased in all cases. Knockdown of p70S6 kinase markedly decreases RET induced transformed phenotypes. Finally, RET is expressed in 18% of adenocarcinomas and all three small-cell carcinomas examined. Conclusions: RET promotes transformation associated phenotypes, including perineural invasion in prostate cancer via activation of p70S6 kinase. GFRα1, which is secreted by nerves, is a limiting factor for RET signaling, creating a perineural niche where RET signaling can occur. Clin Cancer Res; 23(16); 4885-96. ©2017 AACR . ©2017 American Association for Cancer Research.

  7. Rapid actions of xenoestrogens disrupt normal estrogenic signaling.

    Science.gov (United States)

    Watson, Cheryl S; Hu, Guangzhen; Paulucci-Holthauzen, Adriana A

    2014-03-01

    Some chemicals used in consumer products or manufacturing (e.g. plastics, surfactants, pesticides, resins) have estrogenic activities; these xenoestrogens (XEs) chemically resemble physiological estrogens and are one of the major categories of synthesized compounds that disrupt endocrine actions. Potent rapid actions of XEs via nongenomic mechanisms contribute significantly to their disruptive effects on functional endpoints (e.g. cell proliferation/death, transport, peptide release). Membrane-initiated hormonal signaling in our pituitary cell model is predominantly driven by mERα with mERβ and GPR30 participation. We visualized ERα on plasma membranes using many techniques in the past (impeded ligands, antibodies to ERα) and now add observations of epitope proximity with other membrane signaling proteins. We have demonstrated a range of rapid signals/protein activations by XEs including: calcium channels, cAMP/PKA, MAPKs, G proteins, caspases, and transcription factors. XEs can cause disruptions of the oscillating temporal patterns of nongenomic signaling elicited by endogenous estrogens. Concentration effects of XEs are nonmonotonic (a trait shared with natural hormones), making it difficult to design efficient (single concentration) toxicology tests to monitor their harmful effects. A plastics monomer, bisphenol A, modified by waste treatment (chlorination) and other processes causes dephosphorylation of extracellular-regulated kinases, in contrast to having no effects as it does in genomic signaling. Mixtures of XEs, commonly found in contaminated environments, disrupt the signaling actions of physiological estrogens even more severely than do single XEs. Understanding the features of XEs that drive these disruptive mechanisms will allow us to redesign useful chemicals that exclude estrogenic or anti-estrogenic activities. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Characterization of the ABA signal transduction pathway in Vitis vinifera.

    Science.gov (United States)

    Boneh, Uri; Biton, Iris; Schwartz, Amnon; Ben-Ari, Giora

    2012-05-01

    The plant hormone abscisic acid (ABA) regulates many key processes in plants including the response to abiotic stress. ABA signal transduction consists of a double-negative regulatory mechanism, whereby ABA-bound PYR/RCARs inhibit PP2C activity, and PP2Cs inactivate SnRK2s. We studied and analyzed the various genes participating in the ABA signaling cascade of the grape (Vitis vinifera). The grape ABA signal transduction consists of at least six SnRK2s. Yeast two-hybrid system was used to test direct interactions between core components of grape ABA signal transduction. We found that a total of forty eight interactions can occur between the various components. Exogenous abscisic acid (ABA) and abiotic stresses such as drought, high salt concentration and cold, were applied to vines growing in a hydroponic system. These stresses regulated the expression of various grape SnRK2s as well as ABFs in leaves and roots. Based on the interactions between SnRK2s and its targets and the expression pattern, we suggest that VvSnRK2.1 and VvSnRK2.6, can be considered the major VvSnRK2 candidates involved in the stomata response to abiotic stress. Furthermore, we found that the expression pattern of the two grape ABF genes indicates organ specificity of these genes. The key role of ABA signaling in response to abiotic stresses makes the genes involve in this signaling potential candidates for manipulation in programs designed to improve fruit tree performance in extreme environments. © 2012 Elsevier Ireland Ltd. All rights reserved.

  9. Collect and process the signals of isotope measurement

    International Nuclear Information System (INIS)

    Gao Ge; Wu Bingzhe

    2004-01-01

    The article introduces the technology about detecting and dealing on with random signals in isotope measurement for getting energy level region atlas. It describes the circuit design for inspecting superposed signals and method of multichannel analysing. (authors)

  10. Signal Analysis for Radiation Event Identification

    Energy Technology Data Exchange (ETDEWEB)

    Steven A. Wallace

    2004-12-30

    The method of digitizing the scintillation output signals from a lithiated sol-gel based glass is described. The design considerations for using the lithiated scintillator for the detection of Special Nuclear Material (SNM) is presented.

  11. Estimating cognitive reserve in healthy adults using the Cognitive Reserve Scale.

    Directory of Open Access Journals (Sweden)

    Irene León

    Full Text Available The concept of cognitive reserve emerged from observed disparities between brain pathology and clinical symptoms. It may explain better neuropsychological performance in healthy individuals. The objectives of this study were to measure reserve in healthy subjects using a new Cognitive Reserve Scale (CRS, analyze the internal consistency of the CRS, and analyze validity evidence. A total of 117 healthy individuals were divided into two groups: 87 adults (aged 18-64 years and 30 elderly adults (≥65 years. All subjects completed the CRS and a comprehensive neuropsychological battery. The internal consistency of the scale was satisfactory (α = 0.77. No significant differences were observed between genders (t = 0.51, p = 0.611, and age was corrected by averaging the CRS score. The study of validity evidence showed that education affected the CRS (t = -2.98, p = 0.004, partial h2 = 0.07 and there was no significant relationship between the CRS and IQ (r = 0.09, p = 0.33. Occupational attainment and the CRS were not related (F2,116 = 0.11, p = 0.898. In line with previous studies on reserve, heterogeneity was observed in the analyses of relationships between the CRS and cognitive performance. There were significant relationships between CRS score and the Verbal Learning Spanish-Complutense Test last trial (r = 0.24, p = 0.009, sum (r = 0.32, p = 0.000, short-term (r = 0.29, p = 0.002 and long-term memory (r = 0.22, p = 0.018, Matrix Reasoning subtest (r = 0.20, p = 0.027 and Block Design subtest (r = 0.20, p = 0.029. No other neuropsychological variables correlated with the CRS (p>0.05. The CRS is a reliable instrument that reflects the frequency of participation in brain-stimulating activities across the lifetime. The associations between the CRS and education and neuropsychological performance support validity evidence.

  12. Estimating Cognitive Reserve in Healthy Adults Using the Cognitive Reserve Scale

    Science.gov (United States)

    León, Irene; García-García, Juan; Roldán-Tapia, Lola

    2014-01-01

    The concept of cognitive reserve emerged from observed disparities between brain pathology and clinical symptoms. It may explain better neuropsychological performance in healthy individuals. The objectives of this study were to measure reserve in healthy subjects using a new Cognitive Reserve Scale (CRS), analyze the internal consistency of the CRS, and analyze validity evidence. A total of 117 healthy individuals were divided into two groups: 87 adults (aged 18–64 years) and 30 elderly adults (≥65 years). All subjects completed the CRS and a comprehensive neuropsychological battery. The internal consistency of the scale was satisfactory (α = 0.77). No significant differences were observed between genders (t = 0.51, p = 0.611), and age was corrected by averaging the CRS score. The study of validity evidence showed that education affected the CRS (t = −2.98, p = 0.004, partial h2 = 0.07) and there was no significant relationship between the CRS and IQ (r = 0.09, p = 0.33). Occupational attainment and the CRS were not related (F2,116 = 0.11, p = 0.898). In line with previous studies on reserve, heterogeneity was observed in the analyses of relationships between the CRS and cognitive performance. There were significant relationships between CRS score and the Verbal Learning Spanish–Complutense Test last trial (r = 0.24, p = 0.009), sum (r = 0.32, p = 0.000), short-term (r = 0.29, p = 0.002) and long-term memory (r = 0.22, p = 0.018), Matrix Reasoning subtest (r = 0.20, p = 0.027) and Block Design subtest (r = 0.20, p = 0.029). No other neuropsychological variables correlated with the CRS (p>0.05). The CRS is a reliable instrument that reflects the frequency of participation in brain-stimulating activities across the lifetime. The associations between the CRS and education and neuropsychological performance support validity evidence. PMID:25050711

  13. Habitat damage, marine reserves, and the value of spatial management

    KAUST Repository

    Moeller, Holly V.

    2013-07-01

    The biological benefits of marine reserves have garnered favor in the conservation community, but "no-take" reserve implementation is complicated by the economic interests of fishery stakeholders. There are now a number of studies examining the conditions under which marine reserves can provide both economic and ecological benefits. A potentially important reality of fishing that these studies overlook is that fishing can damage the habitat of the target stock. Here, we construct an equilibrium bioeconomic model that incorporates this habitat damage and show that the designation of marine reserves, coupled with the implementation of a tax on fishing effort, becomes both biologically and economically favorable as habitat sensitivity increases. We also study the effects of varied degrees of spatial control on fisheries management. Together, our results provide further evidence for the potential monetary and biological value of spatial management, and the possibility of a mutually beneficial resolution to the fisherman-conservationist marine reserve designation dilemma. © 2013 by the Ecological Society of America.

  14. 48 CFR 4.501 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false [Reserved] 4.501 Section 4.501 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Electronic Commerce in Contracting 4.501 [Reserved...

  15. 7 CFR 300.1 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false [Reserved] 300.1 Section 300.1 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INCORPORATION BY REFERENCE § 300.1 [Reserved...

  16. 7 CFR 305.4 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false [Reserved] 305.4 Section 305.4 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS § 305.4 [Reserved...

  17. 50 CFR 216.42 - Photography. [Reserved

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Photography. [Reserved] 216.42 Section 216.42 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC... MAMMALS Special Exceptions § 216.42 Photography. [Reserved] ...

  18. 9 CFR 73.1a - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false [Reserved] 73.1a Section 73.1a Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS SCABIES IN CATTLE § 73.1a [Reserved] ...

  19. 12 CFR 614.4710 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false [Reserved] 614.4710 Section 614.4710 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LOAN POLICIES AND OPERATIONS Banks for Cooperatives and Agricultural Credit Banks Financing International Trade § 614.4710 [Reserved] ...

  20. 40 CFR 406.43 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 406.43 Section 406.43 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Bulgur Wheat Flour Milling Subcategory § 406.43 [Reserved] ...

  1. 40 CFR 406.23 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 406.23 Section 406.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Corn Dry Milling Subcategory § 406.23 [Reserved] ...

  2. 40 CFR 406.13 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 406.13 Section 406.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Corn Wet Milling Subcategory § 406.13 [Reserved] ...

  3. 24 CFR 891.855 - Replacement reserves.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserves. 891.855... § 891.855 Replacement reserves. (a) The mixed-finance owner shall establish and maintain a replacement... the funds will be used to pay for capital replacement costs for the Section 202 or 811 supportive...

  4. 22 CFR 40.69 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false [Reserved] 40.69 Section 40.69 Foreign Relations DEPARTMENT OF STATE VISAS REGULATIONS PERTAINING TO BOTH NONIMMIGRANTS AND IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Illegal Entrants and Immigration Violators § 40.69 [Reserved] ...

  5. Body reserves in intra-African migrants

    NARCIS (Netherlands)

    Nwaogu, Chima; Cresswell, Will

    Avian migration has been shown to be a life history strategy for surviving environmental resource variability, but it requires increased body reserves for long distance flight. Fat reserves make excellent energy stores for barrier crossing, whereas proteins generate less energy for the same mass of

  6. 21 CFR 211.170 - Reserve samples.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Reserve samples. 211.170 Section 211.170 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL... of deterioration unless visual examination would affect the integrity of the reserve sample. Any...

  7. 8 CFR 325.1 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false [Reserved] 325.1 Section 325.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS NATIONALS BUT NOT CITIZENS OF THE UNITED STATES; RESIDENCE WITHIN OUTLYING POSSESSIONS § 325.1 [Reserved] ...

  8. 30 CFR 253.44 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false [Reserved] 253.44 Section 253.44 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Requirements for Submitting OSFR Information § 253.44 [Reserved] ...

  9. 7 CFR 1709.2 Policy. - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false [Reserved] 1709.2 Policy. Section 1709.2 Policy. Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES General Requirements § 1709.2 Policy. [Reserved] ...

  10. 7 CFR 1709.202 Policy. - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false [Reserved] 1709.202 Policy. Section 1709.202 Policy... AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES Bulk Fuel Revolving Fund Grant Program § 1709.202 Policy. [Reserved] ...

  11. 7 CFR 3560.65 - Reserve account.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Reserve account. 3560.65 Section 3560.65 Agriculture... DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Direct Loan and Grant Origination § 3560.65 Reserve account... account that meets requirements of § 3560.306. At a minimum, the borrower must agree to make monthly...

  12. 21 CFR 720.5 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false [Reserved] 720.5 Section 720.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) COSMETICS VOLUNTARY FILING OF COSMETIC PRODUCT INGREDIENT COMPOSITION STATEMENTS § 720.5 [Reserved] ...

  13. 39 CFR 111.5 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false [Reserved] 111.5 Section 111.5 Postal Service UNITED STATES POSTAL SERVICE POST OFFICE SERVICES [DOMESTIC MAIL] GENERAL INFORMATION ON POSTAL SERVICE § 111.5 [Reserved] ...

  14. 75 FR 44067 - Conservation Reserve Program

    Science.gov (United States)

    2010-07-28

    ... amending the Conservation Reserve Program (CRP) regulations to implement provisions of the Food, Conservation, and Energy Act of 2008 (the 2008 Farm Bill). The 2008 Farm Bill generally extends the existing... Commodity Credit Corporation 7 CFR Part 1410 RIN 0560-AH80 Conservation Reserve Program AGENCY: Commodity...

  15. 7 CFR 1780.8 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1780.8 Section 1780.8 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE LOANS AND GRANTS General Policies and Requirements § 1780.8 [Reserved] ...

  16. 7 CFR 1779.79 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1779.79 Section 1779.79 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.79 [Reserved] ...

  17. 7 CFR 1780.5 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1780.5 Section 1780.5 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE LOANS AND GRANTS General Policies and Requirements § 1780.5 [Reserved] ...

  18. 7 CFR 1779.82 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1779.82 Section 1779.82 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.82 [Reserved] ...

  19. 7 CFR 1779.74 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1779.74 Section 1779.74 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.74 [Reserved] ...

  20. 7 CFR 1780.12 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1780.12 Section 1780.12 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE LOANS AND GRANTS General Policies and Requirements § 1780.12 [Reserved] ...

  1. 7 CFR 1779.26 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1779.26 Section 1779.26 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.26 [Reserved] ...

  2. 20 CFR 410.394 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false [Reserved] 410.394 Section 410.394 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and Dependency § 410.394 [Reserved] ...

  3. 40 CFR 26.1124 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false [Reserved] 26.1124 Section 26.1124 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical...-nursing Adults § 26.1124 [Reserved] ...

  4. 26 CFR 1.46-10 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true [Reserved] 1.46-10 Section 1.46-10 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Rules for Computing Credit for Investment in Certain Depreciable Property § 1.46-10 [Reserved] ...

  5. 34 CFR 97.121 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false [Reserved] 97.121 Section 97.121 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.121 [Reserved] ...

  6. Running on Empty? The Compensatory Reserve Index

    Science.gov (United States)

    2013-12-01

    and HR,31 more blood pressure oscillations,32 and greater vasoconstrictor reserve,33 compared with low-tolerant individuals. By leveraging recent... vasoconstrictor reserves. Clin Auton Res. 2012; 22:123Y130. 32. Rickards CA, Ryan KL, Cooke WH, Convertino VA. Tolerance to central hypovolemia: the

  7. 77 FR 66980 - Federal Reserve Bank Services

    Science.gov (United States)

    2012-11-08

    ... earn net income of $15.3 million, compared with the target of $9.1 million. While the check service and... upgrades, and increase product revenue. 4. 2013 Pricing--The following summarizes the Reserve Banks... the office closed. The Reserve Banks also will introduce incentive pricing for depository institutions...

  8. 15 CFR 2003.3 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false [Reserved] 2003.3 Section 2003.3 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS OF TRADE POLICY STAFF COMMITTEE § 2003.3 [Reserved] ...

  9. The Economics of NASA Mission Cost Reserves

    Science.gov (United States)

    Whitley, Sally; Shinn, Stephen

    2012-01-01

    Increases in NASA mission costs are well-noted but not well-understood, and there is little evidence that they are decreasing in frequency or amount over time. The need to control spending has led to analysis of the causes and magnitude of historical mission overruns, and many program control efforts are being implemented to attempt to prevent or mitigate the problem (NPR 7120). However, cost overruns have not abated, and while some direct causes of increased spending may be obvious (requirements creep, launch delays, directed changes, etc.), the underlying impetus to spend past the original budget may be more subtle. Gaining better insight into the causes of cost overruns will help NASA and its contracting organizations to avoid .them. This paper hypothesizes that one cause of NASA mission cost overruns is that the availability of reserves gives project team members an incentive to make decisions and behave in ways that increase costs. We theorize that the presence of reserves is a contributing factor to cost overruns because it causes organizations to use their funds less efficiently or to control spending less effectively. We draw a comparison to the insurance industry concept of moral hazard, the phenomenon that the presence of insurance causes insureds to have more frequent and higher insurance losses, and we attempt to apply actuarial techniques to quantifY the increase in the expected cost of a mission due to the availability of reserves. We create a theoretical model of reserve spending motivation by defining a variable ReserveSpending as a function of total reserves. This function has a positive slope; for every dollar of reserves available, there is a positive probability of spending it. Finally, the function should be concave down; the probability of spending each incremental dollar of reserves decreases progressively. We test the model against available NASA CADRe data by examining missions with reserve dollars initially available and testing whether

  10. The host plant metabolite glucose is the precursor of diffusible signal factor (DSF) family signals in Xanthomonas campestris.

    Science.gov (United States)

    Deng, Yinyue; Liu, Xiaoling; Wu, Ji'en; Lee, Jasmine; Chen, Shaohua; Cheng, Yingying; Zhang, Chunyan; Zhang, Lian-Hui

    2015-04-01

    Plant pathogen Xanthomonas campestris pv. campestris produces cis-11-methyl-2-dodecenoic acid (diffusible signal factor [DSF]) as a cell-cell communication signal to regulate biofilm dispersal and virulence factor production. Previous studies have demonstrated that DSF biosynthesis is dependent on the presence of RpfF, an enoyl-coenzyme A (CoA) hydratase, but the DSF synthetic mechanism and the influence of the host plant on DSF biosynthesis are still not clear. We show here that exogenous addition of host plant juice or ethanol extract to the growth medium of X. campestris pv. campestris could significantly boost DSF family signal production. It was subsequently revealed that X. campestris pv. campestris produces not only DSF but also BDSF (cis-2-dodecenoic acid) and another novel DSF family signal, which was designated DSF-II. BDSF was originally identified in Burkholderia cenocepacia to be involved in regulation of motility, biofilm formation, and virulence in B. cenocepacia. Functional analysis suggested that DSF-II plays a role equal to that of DSF in regulation of biofilm dispersion and virulence factor production in X. campestris pv. campestris. Furthermore, chromatographic separation led to identification of glucose as a specific molecule stimulating DSF family signal biosynthesis in X. campestris pv. campestris. (13)C-labeling experiments demonstrated that glucose acts as a substrate to provide a carbon element for DSF biosynthesis. The results of this study indicate that X. campestris pv. campestris could utilize a common metabolite of the host plant to enhance DSF family signal synthesis and therefore promote virulence. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  11. Neural networks in signal processing

    International Nuclear Information System (INIS)

    Govil, R.

    2000-01-01

    Nuclear Engineering has matured during the last decade. In research and design, control, supervision, maintenance and production, mathematical models and theories are used extensively. In all such applications signal processing is embedded in the process. Artificial Neural Networks (ANN), because of their nonlinear, adaptive nature are well suited to such applications where the classical assumptions of linearity and second order Gaussian noise statistics cannot be made. ANN's can be treated as nonparametric techniques, which can model an underlying process from example data. They can also adopt their model parameters to statistical change with time. Algorithms in the framework of Neural Networks in Signal processing have found new applications potentials in the field of Nuclear Engineering. This paper reviews the fundamentals of Neural Networks in signal processing and their applications in tasks such as recognition/identification and control. The topics covered include dynamic modeling, model based ANN's, statistical learning, eigen structure based processing and generalization structures. (orig.)

  12. Multichannel Coding of Applause Signals

    Directory of Open Access Journals (Sweden)

    Jeroen Breebaart

    2007-08-01

    Full Text Available We develop a parametric multichannel audio codec dedicated to coding signals consisting of a dense series of transient-type events. These signals of which applause is a typical example are known to be problematic for such audio codecs. The codec design is based on preservation of both timbre and transient-type event density. It combines a very low complexity and a low parameter bit rate (0.2 kbps. In a formal listening test, we compared the proposed codec to the recently standardised MPEG Surround multichannel codec, with an associated parameter bit rate of 9 kbps. We found the new codec to have a significantly higher audio quality than the MPEG Surround codec for the two multichannel applause signals under test. Though this seems promising, the technique presented is not fully mature, for example, because issues related to integration of the proposed codec in the MPEG Surround codec were not addressed.

  13. Multichannel Coding of Applause Signals

    Science.gov (United States)

    Hotho, Gerard; van de Par, Steven; Breebaart, Jeroen

    2007-12-01

    We develop a parametric multichannel audio codec dedicated to coding signals consisting of a dense series of transient-type events. These signals of which applause is a typical example are known to be problematic for such audio codecs. The codec design is based on preservation of both timbre and transient-type event density. It combines a very low complexity and a low parameter bit rate (0.2 kbps). In a formal listening test, we compared the proposed codec to the recently standardised MPEG Surround multichannel codec, with an associated parameter bit rate of 9 kbps. We found the new codec to have a significantly higher audio quality than the MPEG Surround codec for the two multichannel applause signals under test. Though this seems promising, the technique presented is not fully mature, for example, because issues related to integration of the proposed codec in the MPEG Surround codec were not addressed.

  14. 76 FR 64250 - Reserve Requirements of Depository Institutions: Reserves Simplification and Private Sector...

    Science.gov (United States)

    2011-10-18

    ... D; Docket No. R-1433] RIN No. 7100 AD 83 Reserve Requirements of Depository Institutions: Reserves Simplification and Private Sector Adjustment Factor AGENCY: Board of Governors of the Federal Reserve System... public comment on proposed amendments to Regulation D, Reserve Requirements of Depository Institutions...

  15. Frequency domain laser velocimeter signal processor: A new signal processing scheme

    Science.gov (United States)

    Meyers, James F.; Clemmons, James I., Jr.

    1987-01-01

    A new scheme for processing signals from laser velocimeter systems is described. The technique utilizes the capabilities of advanced digital electronics to yield a smart instrument that is able to configure itself, based on the characteristics of the input signals, for optimum measurement accuracy. The signal processor is composed of a high-speed 2-bit transient recorder for signal capture and a combination of adaptive digital filters with energy and/or zero crossing detection signal processing. The system is designed to accept signals with frequencies up to 100 MHz with standard deviations up to 20 percent of the average signal frequency. Results from comparative simulation studies indicate measurement accuracies 2.5 times better than with a high-speed burst counter, from signals with as few as 150 photons per burst.

  16. Cognitive reserve and appraisal in multiple sclerosis.

    Science.gov (United States)

    Schwartz, Carolyn E; Snook, Erin; Quaranto, Brian; Benedict, Ralph H B; Rapkin, Bruce D; Vollmer, Timothy

    2013-01-01

    Cognitive appraisal processes underlying self-report affect the interpretation of patient-reported outcomes. These processes are relevant to resilience and adaptability, and may relate to how cognitive reserve protects against disability in multiple sclerosis (MS). To describe how passive and active indicators of cognitive reserve relate to QOL appraisal processes in MS. Cross-sectional data (n=860) were drawn from the North American Research Committee on MS (NARCOMS) Registry, from whom additional survey data were collected. Cognitive reserve was measured using the Stern and Sole-Padulles measures. Using the quality of life appraisal profile (QOLAP), we assessed how MS patients conceptualize their experiences and how that impacts how they report their quality of life. Multivariate analysis of variance was used to compare groups within sets of appraisal parameters, and t-tests or chi-square tests were used to compare mean item responses within appraisal parameters for continuous or dichotomous variables, respectively. People high in passive or active reserve report different conceptualizations of QOL, different types of goals, and considering different types of experiences and standards of comparison in responding to QOL questionnaires, as compared to low-reserve individuals. Although item response patterns were slightly different between passive and active indicators, they generally reflect a tendency in high-reserve individuals to emphasize the positive, focus on aspects of their life that are more controllable, and less based in fantasy. MS patients high in cognitive reserve differ in their cognitive appraisals from their low reserve counterparts. These appraisal metrics may predict disease course and other important clinical outcomes in MS patients. Copyright © 2012 Elsevier B.V. All rights reserved.

  17. Radar signal processing and its applications

    CERN Document Server

    Hummel, Robert; Stoica, Petre; Zelnio, Edmund

    2003-01-01

    Radar Signal Processing and Its Applications brings together in one place important contributions and up-to-date research results in this fast-moving area. In twelve selected chapters, it describes the latest advances in architectures, design methods, and applications of radar signal processing. The contributors to this work were selected from the leading researchers and practitioners in the field. This work, originally published as Volume 14, Numbers 1-3 of the journal, Multidimensional Systems and Signal Processing, will be valuable to anyone working or researching in the field of radar signal processing. It serves as an excellent reference, providing insight into some of the most challenging issues being examined today.

  18. Plant monitoring and signal validation at HFIR

    International Nuclear Information System (INIS)

    Mullens, J.A.

    1991-01-01

    This paper describes a monitoring system for the Oak Ridge National Laboratory's (ORNL'S) High Flux Isotope Reactor (HFIR). HFIR is an 85 MW pressurized water reactor designed to produce isotopes and intense neutron beams. The monitoring system is described with respect to plant signals and computer system; monitoring overview; data acquisition, logging and network distribution; signal validation; status displays; reactor condition monitoring; reactor operator aids. Future work will include the addition of more plant signals, more signal validation and diagnostic capabilities, improved status display, integration of the system with the RELAP plant simulation and graphical interface, improved operator aids, and an alarm filtering system. 8 refs., 7 figs. (MB)

  19. Strategic Petroleum Reserve: Annual/quarterly report

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-16

    Section 165 of the Energy Policy and Conservation Act (Public Law 94-163), as amended, requires the Secretary of Energy to submit annual and quarterly reports to the President and the Congress on activities of the Strategic Petroleum Reserve. This report combines the fourth quarter 1993 Quarterly Report with the 1993 Annual Report. Key activities described include appropriations; life extension planning; expansion planning; Strategic Petroleum Reserve oil acquisition; the oil stabilization program; and the refined petroleum product reserve test programs. Sections of this report also describe the program mission; the storage facility development program; environmental compliance; budget and finance; and drawdown and distribution.

  20. Advances in heuristic signal processing and applications

    CERN Document Server

    Chatterjee, Amitava; Siarry, Patrick

    2013-01-01

    There have been significant developments in the design and application of algorithms for both one-dimensional signal processing and multidimensional signal processing, namely image and video processing, with the recent focus changing from a step-by-step procedure of designing the algorithm first and following up with in-depth analysis and performance improvement to instead applying heuristic-based methods to solve signal-processing problems. In this book the contributing authors demonstrate both general-purpose algorithms and those aimed at solving specialized application problems, with a spec

  1. Analog and mixed-signal electronics

    CERN Document Server

    Stephan, Karl

    2015-01-01

    A practical guide to analog and mixed-signal electronics, with an emphasis on design problems and applications This book provides an in-depth coverage of essential analog and mixed-signal topics such as power amplifiers, active filters, noise and dynamic range, analog-to-digital and digital-to-analog conversion techniques, phase-locked loops, and switching power supplies. Readers will learn the basics of linear systems, types of nonlinearities and their effects, op-amp circuits, the high-gain analog filter-amplifier, and signal generation. The author uses system design examples to motivate

  2. Sonic Interaction Design

    DEFF Research Database (Denmark)

    Sound is an integral part of every user experience but a neglected medium in design disciplines. Design of an artifact’s sonic qualities is often limited to the shaping of functional, representational, and signaling roles of sound. The interdisciplinary field of sonic interaction design (SID) cha...

  3. Operational Army Reserve Implications for Organizational Health

    National Research Council Canada - National Science Library

    Dahms, Jonathan A

    2007-01-01

    The Army Reserve has been in a constant state of mobilization since 1995 with the advent of the Bosnia crisis and the pace of mobilization increased exponentially after the terrorist attacks of September 11, 2001...

  4. Communicating marine reserve science to diverse audiences

    Science.gov (United States)

    Grorud-Colvert, Kirsten; Lester, Sarah E.; Airamé, Satie; Neeley, Elizabeth; Gaines, Steven D.

    2010-01-01

    As human impacts cause ecosystem-wide changes in the oceans, the need to protect and restore marine resources has led to increasing calls for and establishment of marine reserves. Scientific information about marine reserves has multiplied over the last decade, providing useful knowledge about this tool for resource users, managers, policy makers, and the general public. This information must be conveyed to nonscientists in a nontechnical, credible, and neutral format, but most scientists are not trained to communicate in this style or to develop effective strategies for sharing their scientific knowledge. Here, we present a case study from California, in which communicating scientific information during the process to establish marine reserves in the Channel Islands and along the California mainland coast expanded into an international communication effort. We discuss how to develop a strategy for communicating marine reserve science to diverse audiences and highlight the influence that effective science communication can have in discussions about marine management. PMID:20427745

  5. 48 CFR 9904.404-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.404-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.404-10 [Reserved] ...

  6. 48 CFR 9904.401-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.401-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.401-10 [Reserved] ...

  7. 48 CFR 9904.400 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.400 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.400 [Reserved] ...

  8. 48 CFR 9904.402-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.402-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.402-10 [Reserved] ...

  9. 48 CFR 9904.405-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.405-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.405-10 [Reserved] ...

  10. 48 CFR 9904.407-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.407-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.407-10 [Reserved] ...

  11. 48 CFR 9904.408-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.408-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.408-10 [Reserved] ...

  12. 48 CFR 9904.406-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.406-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.406-10 [Reserved] ...

  13. 48 CFR 9904.403-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.403-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.403-10 [Reserved] ...

  14. 10 CFR 51.110 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) Rulemaking § 51.110 [Reserved] Public Notice of and Access to Environmental Documents ...

  15. U.S. Federal Reserve Systems

    Data.gov (United States)

    Department of Homeland Security — This dataset is comprised of forty-five entities that are part of the United States Federal Reserve System according to the United States Department of Treasury. The...

  16. Communicating marine reserve science to diverse audiences.

    Science.gov (United States)

    Grorud-Colvert, Kirsten; Lester, Sarah E; Airamé, Satie; Neeley, Elizabeth; Gaines, Steven D

    2010-10-26

    As human impacts cause ecosystem-wide changes in the oceans, the need to protect and restore marine resources has led to increasing calls for and establishment of marine reserves. Scientific information about marine reserves has multiplied over the last decade, providing useful knowledge about this tool for resource users, managers, policy makers, and the general public. This information must be conveyed to nonscientists in a nontechnical, credible, and neutral format, but most scientists are not trained to communicate in this style or to develop effective strategies for sharing their scientific knowledge. Here, we present a case study from California, in which communicating scientific information during the process to establish marine reserves in the Channel Islands and along the California mainland coast expanded into an international communication effort. We discuss how to develop a strategy for communicating marine reserve science to diverse audiences and highlight the influence that effective science communication can have in discussions about marine management.

  17. The Economics of NASA Mission Cost Reserves

    Science.gov (United States)

    Whitley, Sally; Shinn, Stephen

    2012-01-01

    Increases in NASA mission costs have led to analysis of the causes and magnitude of historical mission overruns as well as mitigation and prevention attempts. This paper hypothesizes that one cause is that the availability of reserves may reduce incentives to control costs. We draw a comparison to the insurance concept of moral hazard, and we use actuarial techniques to better understand the increase in mission costs due to the availability of reserves. NASA's CADRe database provided the data against which we tested our hypothesis and discovered that there is correlation between the amount of available reserves and project overruns, particularly for mission hardware cost increases. We address the question of how to prevent reserves from increasing mission spending without increasing cost risk to projects.

  18. 40 CFR 63.131 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for Organic Hazardous Air Pollutants From the Synthetic Organic Chemical Manufacturing Industry for Process Vents, Storage Vessels, Transfer Operations, and Wastewater § 63.131 [Reserved] ...

  19. Low power digital signal processing

    DEFF Research Database (Denmark)

    Paker, Ozgun

    2003-01-01

    This thesis introduces a novel approach to programmable and low power platform design for audio signal processing, in particular hearing aids. The proposed programmable platform is a heterogeneous multiprocessor architecture consisting of small and simple instruction set processors called mini......-cores as well as standard DSP/CPU-cores that communicate using message passing. The work has been based on a study of the algorithm suite covering the application domain. The observation of dominant tasks for certain algorithms (FIR, IIR, correlation, etc.) that require custom computational units and special...... data addressing capabilities lead to the design of low power mini-cores. The algorithm suite also consisted of less demanding and/or irregular algorithms (LMS, compression) that required subsample rate signal processing justifying the use of a DSP/CPU-core. The thesis also contributes to the recent...

  20. A comb filter based signal processing method to effectively reduce motion artifacts from photoplethysmographic signals.

    Science.gov (United States)

    Peng, Fulai; Liu, Hongyun; Wang, Weidong

    2015-10-01

    A photoplethysmographic (PPG) signal can provide very useful information about a subject's cardiovascular status. Motion artifacts (MAs), which usually deteriorate the waveform of a PPG signal, severely obstruct its applications in the clinical diagnosis and healthcare area. To reduce the MAs from a PPG signal, in the present study we present a comb filter based signal processing method. Firstly, wavelet de-noising was implemented to preliminarily suppress a part of the MAs. Then, the PPG signal in the time domain was transformed into the frequency domain by a fast Fourier transform (FFT). Thirdly, the PPG signal period was estimated from the frequency domain by tracking the fundamental frequency peak of the PPG signal. Lastly, the MAs were removed by the comb filter which was designed based on the obtained PPG signal period. Experiments with synthetic and real-world datasets were implemented to validate the performance of the method. Results show that the proposed method can effectively restore the PPG signals from the MA corrupted signals. Also, the accuracy of blood oxygen saturation (SpO2), calculated from red and infrared PPG signals, was significantly improved after the MA reduction by the proposed method. Our study demonstrates that the comb filter can effectively reduce the MAs from a PPG signal provided that the PPG signal period is obtained.