WorldWideScience

Sample records for reservation property line

  1. Altering graphene line defect properties using chemistry

    Science.gov (United States)

    Vasudevan, Smitha; White, Carter; Gunlycke, Daniel

    2012-02-01

    First-principles calculations are presented of a fundamental topological line defect in graphene that was observed and reported in Nature Nanotech. 5, 326 (2010). These calculations show that atoms and smaller molecules can bind covalently to the surface in the vicinity of the graphene line defect. It is also shown that the chemistry at the line defect has a strong effect on its electronic and magnetic properties, e.g. the ferromagnetically aligned moments along the line defect can be quenched by some adsorbates. The strong effect of the adsorbates on the line defect properties can be understood by examining how these adsorbates affect the boundary-localized states in the vicinity of the Fermi level. We also expect that the line defect chemistry will significantly affect the scattering properties of incident low-energy particles approaching it from graphene.

  2. Regional seismic lines reprocessed using post-stack processing techniques; National Petroleum Reserve, Alaska

    Science.gov (United States)

    Miller, John J.; Agena, W.F.; Lee, M.W.; Zihlman, F.N.; Grow, J.A.; Taylor, D.J.; Killgore, Michele; Oliver, H.L.

    2000-01-01

    This CD-ROM contains stacked, migrated, 2-Dimensional seismic reflection data and associated support information for 22 regional seismic lines (3,470 line-miles) recorded in the National Petroleum Reserve ? Alaska (NPRA) from 1974 through 1981. Together, these lines constitute about one-quarter of the seismic data collected as part of the Federal Government?s program to evaluate the petroleum potential of the Reserve. The regional lines, which form a grid covering the entire NPRA, were created by combining various individual lines recorded in different years using different recording parameters. These data were reprocessed by the USGS using modern, post-stack processing techniques, to create a data set suitable for interpretation on interactive seismic interpretation computer workstations. Reprocessing was done in support of ongoing petroleum resource studies by the USGS Energy Program. The CD-ROM contains the following files: 1) 22 files containing the digital seismic data in standard, SEG-Y format; 2) 1 file containing navigation data for the 22 lines in standard SEG-P1 format; 3) 22 small scale graphic images of each seismic line in Adobe Acrobat? PDF format; 4) a graphic image of the location map, generated from the navigation file, with hyperlinks to the graphic images of the seismic lines; 5) an ASCII text file with cross-reference information for relating the sequential trace numbers on each regional line to the line number and shotpoint number of the original component lines; and 6) an explanation of the processing used to create the final seismic sections (this document). The SEG-Y format seismic files and SEG-P1 format navigation file contain all the information necessary for loading the data onto a seismic interpretation workstation.

  3. Properties of 3-dimensional line location models

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik; Schöbel, Anita

    2002-01-01

    We consider the problem of locating a line with respect to some existing facilities in 3-dimensional space, such that the sum of weighted distances between the line and the facilities is minimized. Measuring distance using the l\\_p norm is discussed, along with the special cases of Euclidean...

  4. On the welfare properties of fractional reserve banking

    OpenAIRE

    Sanches, Daniel R.

    2015-01-01

    Supersedes Working Paper 13-32/R. Monetary economists have long recognized a tension between the benefits of fractional reserve banking, such as the ability to undertake more profitable (long-term) investment opportunities, and the difficulties associated with it, such as the risk of in-solvency for each bank and the associated losses to bank liability holders. I show that a specific banking arrangement (a joint-liability scheme) provides an effective mechanism for ensuring the ex-post transf...

  5. International strategies for growth : monetizing gas reserves to add value to the bottom line

    International Nuclear Information System (INIS)

    Mihaichuk, G.

    1998-01-01

    The direction taken by oil and gas companies, including TransCanada International, in their strategy for growth in global energy markets was discussed. The role that gas plays in meeting the objectives was examined and the different ways in which gas reserves and investments in the gas sector are being turned into high-performing vehicles for adding value to the bottom line were described. Deregulation of, and competition within, the gas and electric power industries are the driving factors for changes within the energy industries. Natural gas will be a winner because it is the first choice for new power generation. Many companies have entered the international playing field to take advantage of the opportunities in international markets. The problems and solutions to monetizing natural gas reserves, some of the international political issues such as regulatory uncertainty, cross-border disputes, lack of regional integration, and sanctions, and how these adverse effects may be mitigated through mergers, acquisitions, or joint ventures, are explored. 14 figs

  6. Properties of on-line social systems

    Science.gov (United States)

    Grabowski, A.; Kruszewska, N.; Kosiński, R. A.

    2008-11-01

    We study properties of five different social systems: (i) internet society of friends consisting of over 106 people, (ii) social network consisting of 3 × 104 individuals, who interact in a large virtual world of Massive Multiplayer Online Role Playing Games (MMORPGs), (iii) over 106 users of music community website, (iv) over 5 × 106 users of gamers community server and (v) over 0.25 × 106 users of books admirer website. Individuals included in large social network form an Internet community and organize themselves in groups of different sizes. The destiny of those systems, as well as the method of creating of new connections, are different, however we found that the properties of these networks are very similar. We have found that the network components size distribution follow the power-law scaling form. In all five systems we have found interesting scaling laws concerning human dynamics. Our research has shown how long people are interested in a single task, how much time they devote to it and how fast they are making friends. It is surprising that the time evolution of an individual connectivity is very similar in each system.

  7. Spectral properties of AGN with very weak [O III] lines

    Directory of Open Access Journals (Sweden)

    Kovačević J.

    2011-01-01

    Full Text Available The spectral properties of a sample of 58 Active Galactic Nuclei (AGN spectra, in which emission [O III] λλ4959, 5007 Å lines are weak or totally absent, are analyzed. In order to investigate the physical reason for the [O III] emission suppression, the spectral properties of the weak [O III] spectra sample are compared with the same properties of a sample of 269 spectra with the strong [O III] lines. The spectra are obtained from Sloan Digital Sky Survey (SDSS Database. It is found that the objects with the weak or absent [O III] λλ4959, 5007 Å lines generally have the high continuum luminosities (log(λL5100 > 45, that they are very rare at smaller redshifts (z < 0.3 and that they usually have strong starburst influence. From the sample with weak or absent [O III] lines, two boundary subgroups may be distinguished: the subgroup with a strong Hβ narrow component and subgroup with a very weak or negligible Hβ narrow component. The physical causes for the [O III] lines suppressing are probably different in these two subgroups: the [O III] lines are absent in objects with strong narrow Hβ probably because of strong starburst (SB activity, which produces high density of the gas, while in the objects with the negligible narrow Hβ, the reason for [O III] and narrow Hβ suppression may be a low covering factor.

  8. Federal Reserve Swap Lines – International Lender of the Last Resort

    Directory of Open Access Journals (Sweden)

    Miroslav Titze

    2016-08-01

    Full Text Available After 2007, financial market turmoil began and shortage of dollar funding liquidity disrupted not only the US dollar funding market but also overseas. To address the shortage of dollar liquidity, the FED introduced swap lines with systematic important central banks, including emerging markets. The paper discusses the main feature of the FED’s swap lines in the context of the funding pressures on the FX swap market. The main objective of the paper is to reveal technical aspects and effectiveness of the swap lines. The paper explains connectivity between un/secured money markets and the FX swap market during the financial and debt crises. The FX swap market was hit significantly. During the liquidity crisis of 2007–2010, the main driver of the deviation from covered interest parity was a shortage of dollar liquidity jointly with counterparty risk. During the debt crisis, the main driver was counterparty risk of the euro zone banks and sovereigns. The FED swap lines were used as a liquidity backstop. The paper concludes that the swap lines were an effective tool of cooperation between central banks and significantly alleviated the pressure on the FX swap market. In addition, the swap lines were flexible, supported financial stability, no losses were recorded, the problem of adverse selection was avoided and exit was successful. Finally, the swap lines have become a permanent tool for solving temporary shortages of foreign currency liquidity in national banking systems.

  9. 50 CFR 660.716 - Surface hook-and-line fishery. [Reserved

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Surface hook-and-line fishery. 660.716 Section 660.716 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES Highly...

  10. Enhanced THz guiding properties of curved two-wire lines.

    Science.gov (United States)

    Zha, Jingshu; Kim, Geun Ju; Jeon, Tae-In

    2016-03-21

    We present experimental and simulation studies of enhanced terahertz (THz) guiding properties of curved two-wire lines for several surface conditions. When a THz-wave propagates through curved two-wire lines, a rough wire surface with dielectric coating contributes to a lower bending loss compared to a smooth or rough wire surface without coating. Dielectric coating and rough surface confine the THz field to the wire surface making the bending loss low. The guiding property at a curve depth of 30 mm of a rough wire surface with 25-μm-thick coating is improved by 34% compared to that of a smooth wire without coating. Furthermore, computer simulation technology (CST) software visually shows the bending loss as same as the experimental studies.

  11. Spectral Properties of AGN with Very Weak [O III] Lines

    Directory of Open Access Journals (Sweden)

    Kovacevic, J.

    2011-06-01

    Full Text Available The spectral properties of a sample of 58 Active GalacticNuclei (AGN spectra, in which emission [O~III] $lambdalambda$4959, 5007 AA lines are weak or totally absent, are analyzed. In order to investigate thephysical reason for the [O~III] emission suppression, the spectral propertiesof the weak [O~III] spectra sample are compared with the same properties of asample of 269 spectra with the strong [O~III] lines. The spectra are obtainedfrom Sloan Digital Sky Survey (SDSS Database. It is found that the objectswith the weak or absent [O~III] $lambdalambda$4959, 5007 AA linesgenerally have the high continuum luminosities (log($lambda$L$_{5100}$ $>$45, that they are very rare at smaller redshifts ($z <$ 0.3 and that theyusually have strong starburst influence. From the sample with weak or absent[O~III] lines, two boundary subgroups may be distinguished: the subgroup witha strong H$beta$ narrow component and subgroup with a very weak or negligibleH$beta$ narrow component. The physical causes for the [O~III] linessuppressing are probably different in these two subgroups: the [O~III] linesare absent in objects with strong narrow H$beta$ probably because of strongstarburst (SB activity, which produces high density of the gas, while in theobjects with the negligible narrow H$beta$, the reason for [O~III] and narrowH$beta$ suppression may be a low covering factor.

  12. Thermal Properties of Starch From New Corn Lines as Impacted by Environment and During Line Development

    Energy Technology Data Exchange (ETDEWEB)

    Lenihan, Elizabeth M [Iowa State Univ., Ames, IA (United States)

    2003-01-01

    The objectives of this research were to further characterize exotic by adapted corn inbreds by studying the impact of environment on their starch thermal properties, and investigating the development of starch thermal properties during kernel maturation by using differential scanning calorimetry (DSC). A method to expedite identification of unusual starch thermal traits was investigated by examining five corn kernels at a time, instead of one kernel, which the previous screening methods used. Corn lines with known thermal functions were blended with background starch (control) in ratios of unique starch to control starch, and analyzed by using DSC. Control starch was representative of typical corn starch. The values for each ratio within a mutant type were unique (α < 0.01) for most DSC measurements. These results supported the five-kernel method for rapidly screening large amounts of corn germplasm to identify unusual starch traits. The effects of 5 growing locations on starch thermal properties from exotic by adapted corn and Corn Belt lines were studied using DSC. The warmest location, Missouri, generally produced starch with greater gelatinization onset temperature (ToG), narrower range of gelatinization (RG), and greater enthalpy of gelatinization (ΔHG). The coolest location, Illinois, generally resulted in starch with lower ToG, wider RG, and lower ΔHG. Starch from the Ames 1 farm had thermal properties similar to those of Illinois, whereas starch from the Ames 2 farm had thermal properties similar to those of Missouri. The temperature at Ames 2 may have been warmer since it was located near a river; however, soil type and quality also were different. Final corn starch structure and function change during development and maturity. Thus, the changes in starch thermal properties during 5 stages of endosperm development from exotic by adapted corn and Corn Belt lines at two locations were

  13. Derelict fishing line provides a useful proxy for estimating levels of non-compliance with no-take marine reserves.

    Science.gov (United States)

    Williamson, David H; Ceccarelli, Daniela M; Evans, Richard D; Hill, Jos K; Russ, Garry R

    2014-01-01

    No-take marine reserves (NTMRs) are increasingly being established to conserve or restore biodiversity and to enhance the sustainability of fisheries. Although effectively designed and protected NTMR networks can yield conservation and fishery benefits, reserve effects often fail to manifest in systems where there are high levels of non-compliance by fishers (poaching). Obtaining reliable estimates of NTMR non-compliance can be expensive and logistically challenging, particularly in areas with limited or non-existent resources for conducting surveillance and enforcement. Here we assess the utility of density estimates and re-accumulation rates of derelict (lost and abandoned) fishing line as a proxy for fishing effort and NTMR non-compliance on fringing coral reefs in three island groups of the Great Barrier Reef Marine Park (GBRMP), Australia. Densities of derelict fishing line were consistently lower on reefs within old (>20 year) NTMRs than on non-NTMR reefs (significantly in the Palm and Whitsunday Islands), whereas line densities did not differ significantly between reefs in new NTMRs (5 years of protection) and non-NTMR reefs. A manipulative experiment in which derelict fishing lines were removed from a subset of the monitoring sites demonstrated that lines re-accumulated on NTMR reefs at approximately one third (32.4%) of the rate observed on non-NTMR reefs over a thirty-two month period. Although these inshore NTMRs have long been considered some of the best protected within the GBRMP, evidence presented here suggests that the level of non-compliance with NTMR regulations is higher than previously assumed.

  14. Derelict fishing line provides a useful proxy for estimating levels of non-compliance with no-take marine reserves.

    Directory of Open Access Journals (Sweden)

    David H Williamson

    Full Text Available No-take marine reserves (NTMRs are increasingly being established to conserve or restore biodiversity and to enhance the sustainability of fisheries. Although effectively designed and protected NTMR networks can yield conservation and fishery benefits, reserve effects often fail to manifest in systems where there are high levels of non-compliance by fishers (poaching. Obtaining reliable estimates of NTMR non-compliance can be expensive and logistically challenging, particularly in areas with limited or non-existent resources for conducting surveillance and enforcement. Here we assess the utility of density estimates and re-accumulation rates of derelict (lost and abandoned fishing line as a proxy for fishing effort and NTMR non-compliance on fringing coral reefs in three island groups of the Great Barrier Reef Marine Park (GBRMP, Australia. Densities of derelict fishing line were consistently lower on reefs within old (>20 year NTMRs than on non-NTMR reefs (significantly in the Palm and Whitsunday Islands, whereas line densities did not differ significantly between reefs in new NTMRs (5 years of protection and non-NTMR reefs. A manipulative experiment in which derelict fishing lines were removed from a subset of the monitoring sites demonstrated that lines re-accumulated on NTMR reefs at approximately one third (32.4% of the rate observed on non-NTMR reefs over a thirty-two month period. Although these inshore NTMRs have long been considered some of the best protected within the GBRMP, evidence presented here suggests that the level of non-compliance with NTMR regulations is higher than previously assumed.

  15. Physical properties of orbital debris from squiggly lines

    Science.gov (United States)

    Jorgensen, K.; Africano, J.; Hamada, K.; Stansbery, E.; Sydney, P.; Kervin, P.

    Currently, certain physical properties, such as material type and albedo, of orbital debris are assumed when used to determine the size of the objects. A study to ascertain whether or not the assumed values are valid has begun using reflectance spectroscopy as a means of determining the material type of the object. What appears to some as a squiggly line is actually the reflectance of sunlight from the object. By comparing the location, depth, and width of the absorption features on the squiggly lines, the material type of the debris object is identified. Once the material type is known, the albedo of the object can be determined. This paper discusses the results from observations of large rocket bodies and satellites in both lower and geosynchronous Earth orbits (LEO and GEO, respectively) taken at the Air Force Maui Optical Supercomputing (AMOS) site located in Maui, Hawaii. Using the 1.6- meter telescope and a spectral range of 0.3 to 0.9 microns, differences between rocket bodies of different types and launch dates, as well as satellites of different types and launch dates are determined. Variations seen in the squiggle lines are due to colors of paint, space weathering, and for the satellites, orientation and size of the solar panels. Initial findings from an additional observation run using the 3.67-meter telescope equipped with both a visible and near-infrared spectrometer (out to 2 microns) are also described. Future direction of the project will be discussed as well as plans for future observations.

  16. The dispense of legal reserve in the registration of property: decrease of environmental protection?

    Directory of Open Access Journals (Sweden)

    Thiago de Miranda Carneiro

    2016-12-01

    Full Text Available It is intended to analyze the rural environmental registry and exemption from the registration of the legal reserve on the basis of Law 12.651/12. They will be addressed elements of environmental protection and real estate to handle the revocation of registration of the legal reserve in real estate registry and their inclusion in the CAR, as well as property registration paper and registral advertising in order to ascertain the legal traffic safety real estate. We used exploratory method  through literature and document analysis starting at the constitutional and environmental law through the registral law.

  17. Focusing and matching properties of the ATR transfer line

    International Nuclear Information System (INIS)

    Tsoupas, N.; Fischer, W.; Kewisch, J.; MacKay, W.W.; Peggs, S.; Pilat, F.; Tepikian, S.; Wei, J.

    1997-01-01

    The AGS to RHIC (AtR) beam transfer line has been constructed and will be used to transfer beam bunches from the AGS machine into the RHIC machine which is presently under construction at BNL. The original design of the AtR line has been modified. This article will present the optics of the various sections of the existing AtR beam line, as well as the matching capabilities of the AtR line to the RHIC machine

  18. Isolation of a Wheat Cell Line with Altered Membrane Properties

    Science.gov (United States)

    Erdei, László; Vigh, László; Dudits, Dénes

    1982-01-01

    A spontaneous dimethylsulfoxide (DMSO)-tolerant cell line was isolated from a cell culture of wheat (Triticum monococcum L.). The tolerant cells were able to grow in the presence of 4% DMSO. Cells formed from protoplasts of the tolerant line required DMSO for division in culture medium of high osmotic value. Fatty acid composition and the molar ratio of phospholipids/sterols suggest a more ordered membrane structure in the tolerant line. Accordingly, a lower K+ influx rate was detected in the tolerant cells in comparison with the original line. These characteristics were maintained after 6 months' cultivation of the cells in DMSO-free growth medium. This suggested that genetic changes could be responsible for differences between the two cell lines. PMID:16662251

  19. Contact line motion over heated substrates with spatially nonuniform wetting properties

    Science.gov (United States)

    Ajaev, V. S.; Gatapova, E. Ya

    2017-11-01

    We develop mathematical models of moving contact lines over flat heated solid surfaces with spatial variation of wetting properties under the conditions when evaporation is significant. The gas phase is assumed to be pure vapor and a lubrication-type framework is employed for describing viscous flow in the liquid. Substrate wetting properties are modeled through disjoining pressure, with the main focus on how the contact line motion changes near the regions of localized spatial variation of wetting properties.

  20. Space density and clustering properties of a new sample of emission-line galaxies

    International Nuclear Information System (INIS)

    Wasilewski, A.J.

    1982-01-01

    A moderate-dispersion objective-prism survey for low-redshift emission-line galaxies has been carried out in an 825 sq. deg. region of sky with the Burrell Schmidt telescope of Case Western Reserve University. A 4 0 prism (300 A/mm at H#betta#) was used with the Illa-J emulsion to show that a new sample of emission-line galaxies is available even in areas already searched with the excess uv-continuum technique. The new emission-line galaxies occur quite commonly in systems with peculiar morphology indicating gravitational interaction with a close companion or other disturbance. About 10 to 15% of the sample are Seyfert galaxies. It is suggested that tidal interaction involving matter infall play a significant role in the generation of an emission-line spectrum. The space density of the new galaxies is found to be similar to the space density of the Makarian galaxies. Like the Markarian sample, the galaxies in the present survey represent about 10% of all galaxies in the absolute magnitude range M/sub p/ = -16 to -22. The observations also indicate that current estimates of dwarf galaxy space densities may be too low. The clustering properties of the new galaxies have been investigated using two approaches: cluster contour maps and the spatial correlation function. These tests suggest that there is weak clustering and possibly superclustering within the sample itself and that the galaxies considered here are about as common in clusters of ordinary galaxies as in the field

  1. 75 FR 27617 - Notice of Intent To Release Certain Properties From Certain Terms, Conditions, Reservations and...

    Science.gov (United States)

    2010-05-17

    ... fair market value of the property has been determined by appraisal to be $2,690,000. The airport will receive at least fair market rental value for the property. Documents reflecting the Sponsor's request are...

  2. 78 FR 37660 - American Surface Lines, LLC-Acquisition and Operation Exemption-Mikrut Properties, LLLP

    Science.gov (United States)

    2013-06-21

    ... assignment from Mikrut Properties, LLLP (MP), and to operate as a common carrier, certain rail lines that...: (a) 1.37 miles (7,215 feet) of rail line, comprised of seven tracks, extending from point of... or near Pelzer Street to a transloading facility owned and operated by MP; and (b) 0.19 miles of rail...

  3. 75 FR 36773 - Notice of Intent To Release Certain Properties From All Terms, Conditions, Reservations and...

    Science.gov (United States)

    2010-06-28

    .... The property will be disposed of for the purpose of commercial development. The fair market value of the property has been determined by appraisal to be $688,810. The airport will receive fair market value for the property, which will be subsequently reinvested in another eligible airport improvement...

  4. 75 FR 12809 - Notice of Intent To Release Certain Properties From All Terms, Conditions, Reservations and...

    Science.gov (United States)

    2010-03-17

    ... as non-aeronautical use. The property will be disposed of for the purpose of municipal use. The fair market value of the property has been determined by appraisal to be $1,061,211. The airport will receive fair market value for the property, which will be subsequently reinvested in another eligible airport...

  5. Symmetry-Related Electromagnetic Properties of Resonator-Loaded Transmission Lines and Applications

    Directory of Open Access Journals (Sweden)

    Jordi Naqui

    2015-05-01

    Full Text Available This paper reviews the recent progress in the analysis and applications of the symmetry-related electromagnetic properties of transmission lines loaded with symmetric configurations of resonant elements. It will be shown that the transmission characteristics of these reactively loaded lines can be controlled by the relative orientation between the line and the resonant elements. Two main types of loaded lines are considered: (i resonance-based structures; and (ii frequency-splitting structures. In resonance-based transmission lines, a line is loaded with a single resonant (and symmetric element. For a perfectly symmetric structure, the line is transparent if the line and resonator exhibit symmetry planes of different electromagnetic nature (electric or magnetic wall, whereas the line exhibits a notch (resonance in the transmission coefficient if the symmetry planes behave as either electric or magnetic walls (symmetric configuration, or if symmetry is broken. In frequency-splitting lines, paired resonators are typically loaded to the transmission line; the structure exhibits a single notch for the symmetric configuration, whereas generally two split notches appear when symmetry is disrupted. Applications of these structures include microwave sensors (e.g., contactless sensors of spatial variables, selective mode suppressors (of application in common-mode suppressed differential lines, for instance and spectral signature barcodes, among others.

  6. Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years

    DEFF Research Database (Denmark)

    El Issaoui, Meryam; Giorgione, Veronica; Mamsen, Linn Salto

    2016-01-01

    OBJECTIVE: To study the impact of first-line antineoplastic treatment on ovarian reserve in young girls returning for ovarian tissue cryopreservation (OTC) in connection with a relapse. DESIGN: Retrospective case-control study. SETTING: University hospitals. PATIENT(S): Sixty-three girls under...

  7. Derelict Fishing Line Provides a Useful Proxy for Estimating Levels of Non-Compliance with No-Take Marine Reserves

    OpenAIRE

    Williamson, David H.; Ceccarelli, Daniela M.; Evans, Richard D.; Hill, Jos K.; Russ, Garry R.

    2014-01-01

    No-take marine reserves (NTMRs) are increasingly being established to conserve or restore biodiversity and to enhance the sustainability of fisheries. Although effectively designed and protected NTMR networks can yield conservation and fishery benefits, reserve effects often fail to manifest in systems where there are high levels of non-compliance by fishers (poaching). Obtaining reliable estimates of NTMR non-compliance can be expensive and logistically challenging, particularly in areas wit...

  8. Formation of structure and properties in welded joints of oil line pipes

    Science.gov (United States)

    Vyboishchik, L. M.; Ioffe, A. V.

    2013-01-01

    The effect of welding and heat treatment modes on mechanical properties and corrosion resistance of welded joints of oil line pipes is studied. It is shown that high-frequency welding followed by high-temperature annealing provides strength and corrosion properties in welds of pipes from low-carbon low-alloy steels at the level of the welded metal.

  9. 78 FR 40545 - Notice of Intent to Release Certain Properties from All Terms, Conditions, Reservations and...

    Science.gov (United States)

    2013-07-05

    ... the City of Orlando and the Federal Aviation Administration for the Orlando International Airport, Orlando, FL AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Request for Public Comment... Orlando International Airport, Orlando, FL from the conditions, reservations, and restrictions as...

  10. What happens to soil ecological properties when conservation reserve program land is disturbed

    Science.gov (United States)

    Each year, expiring Conservation Reserve Program (CRP) contracts results in the conversion of restored CRP land back to croplands, potentially reversing multiple ecological benefits including C sequestration potential and microbial biodiversity. We evaluated microbial community composition (fatty ac...

  11. Quantitative, steady-state properties of Catania's computational model of the operant reserve.

    Science.gov (United States)

    Berg, John P; McDowell, J J

    2011-05-01

    Catania (2005) found that a computational model of the operant reserve (Skinner, 1938) produced realistic behavior in initial, exploratory analyses. Although Catania's operant reserve computational model demonstrated potential to simulate varied behavioral phenomena, the model was not systematically tested. The current project replicated and extended the Catania model, clarified its capabilities through systematic testing, and determined the extent to which it produces behavior corresponding to matching theory. Significant departures from both classic and modern matching theory were found in behavior generated by the model across all conditions. The results suggest that a simple, dynamic operant model of the reflex reserve does not simulate realistic steady state behavior. Copyright © 2011 Elsevier B.V. All rights reserved.

  12. 75 FR 62446 - Notice of Intent To Release Certain Properties From All Terms, Conditions, Reservations and...

    Science.gov (United States)

    2010-10-08

    ... airport property and is currently occupied by a hotel. The fair market value of the Gun Club Road parcel has been determined by appraisal to be $5,875,000. The fair market value of the Australian Avenue...

  13. Temperature induces significant changes in both glycolytic reserve and mitochondrial spare respiratory capacity in colorectal cancer cell lines

    Energy Technology Data Exchange (ETDEWEB)

    Mitov, Mihail I., E-mail: m.mitov@uky.edu [Markey Cancer Center, University of Kentucky, Lexington, KY 40536 (United States); Harris, Jennifer W. [Department of Surgery, University of Kentucky, Lexington, KY 40506 (United States); Alstott, Michael C.; Zaytseva, Yekaterina Y. [Markey Cancer Center, University of Kentucky, Lexington, KY 40536 (United States); Evers, B. Mark [Markey Cancer Center, University of Kentucky, Lexington, KY 40536 (United States); Department of Surgery, University of Kentucky, Lexington, KY 40506 (United States); Butterfield, D. Allan [Markey Cancer Center, University of Kentucky, Lexington, KY 40536 (United States); Department of Chemistry, University of Kentucky, Lexington, KY 40506 (United States)

    2017-05-15

    Thermotherapy, as a method of treating cancer, has recently attracted considerable attention from basic and clinical investigators. A number of studies and clinical trials have shown that thermotherapy can be successfully used as a therapeutic approach for various cancers. However, the effects of temperature on cancer bioenergetics have not been studied in detail with a real time, microplate based, label-free detection approach. This study investigates how changes in temperature affect the bioenergetics characteristics (mitochondrial function and glycolysis) of three colorectal cancer (CRC) cell lines utilizing the Seahorse XF96 technology. Experiments were performed at 32 °C, 37 °C and 42 °C using assay medium conditions and equipment settings adjusted to produce equal oxygen and pH levels ubiquitously at the beginning of all experiments. The results suggest that temperature significantly changes multiple components of glycolytic and mitochondrial function of all cell lines tested. Under hypothermia conditions (32 °C), the extracellular acidification rates (ECAR) of CRC cells were significantly lower compared to the same basal ECAR levels measured at 37 °C. Mitochondrial stress test for SW480 cells at 37 °C vs 42 °C demonstrated increased proton leak while all other OCR components remained unchanged (similar results were detected also for the patient-derived xenograft cells Pt.93). Interestingly, the FCCP dose response at 37 °C vs 42 °C show significant shifts in profiles, suggesting that single dose FCCP experiments might not be sufficient to characterize the mitochondrial metabolic potential when comparing groups, conditions or treatments. These findings provide valuable insights for the metabolic and bioenergetic changes of CRC cells under hypo- and hyperthermia conditions that could potentially lead to development of better targeted and personalized strategies for patients undergoing combined thermotherapy with chemotherapy.

  14. Temperature induces significant changes in both glycolytic reserve and mitochondrial spare respiratory capacity in colorectal cancer cell lines

    International Nuclear Information System (INIS)

    Mitov, Mihail I.; Harris, Jennifer W.; Alstott, Michael C.; Zaytseva, Yekaterina Y.; Evers, B. Mark; Butterfield, D. Allan

    2017-01-01

    Thermotherapy, as a method of treating cancer, has recently attracted considerable attention from basic and clinical investigators. A number of studies and clinical trials have shown that thermotherapy can be successfully used as a therapeutic approach for various cancers. However, the effects of temperature on cancer bioenergetics have not been studied in detail with a real time, microplate based, label-free detection approach. This study investigates how changes in temperature affect the bioenergetics characteristics (mitochondrial function and glycolysis) of three colorectal cancer (CRC) cell lines utilizing the Seahorse XF96 technology. Experiments were performed at 32 °C, 37 °C and 42 °C using assay medium conditions and equipment settings adjusted to produce equal oxygen and pH levels ubiquitously at the beginning of all experiments. The results suggest that temperature significantly changes multiple components of glycolytic and mitochondrial function of all cell lines tested. Under hypothermia conditions (32 °C), the extracellular acidification rates (ECAR) of CRC cells were significantly lower compared to the same basal ECAR levels measured at 37 °C. Mitochondrial stress test for SW480 cells at 37 °C vs 42 °C demonstrated increased proton leak while all other OCR components remained unchanged (similar results were detected also for the patient-derived xenograft cells Pt.93). Interestingly, the FCCP dose response at 37 °C vs 42 °C show significant shifts in profiles, suggesting that single dose FCCP experiments might not be sufficient to characterize the mitochondrial metabolic potential when comparing groups, conditions or treatments. These findings provide valuable insights for the metabolic and bioenergetic changes of CRC cells under hypo- and hyperthermia conditions that could potentially lead to development of better targeted and personalized strategies for patients undergoing combined thermotherapy with chemotherapy.

  15. Investigation of soil physical properties under Shorea peltata sym in Tengaroh Forest Reserve, Johor Bahru, Malaysia

    Directory of Open Access Journals (Sweden)

    Musalam Mohammed Abdalmoula

    2016-01-01

    Full Text Available Soil properties of tropical rain forest in Southeast Asia have been characterized by several researchers. However, empirical data on soil characteristics under rehabilitation program are still limited or even lacking. A study was conducted to characterize the soil physical properties under different densities of Shorea peltata species. The objective of the research was to determine the relationship between Shorea peltata species and soil physical properties. Twenty observational plots, 50 X 50 m namely, rare (A, low (B, moderate (C and high (D densities were established. Each plot was divided into 10 subplots. Five subplots were selected randomly. Soil samples were collected using auger at 0 - 15 cm, and core-ring at 0 - 10 cm depth. The results show that there was a significant difference among the groups. Analysis of the relationship between soil physical properties and site variables showed that moisture content, bulk density, particle density, silt and clay were the important factors in the distribution of Shorea peltata species in the study sites.

  16. LINES

    Directory of Open Access Journals (Sweden)

    Minas Bakalchev

    2015-10-01

    Full Text Available The perception of elements in a system often creates their interdependence, interconditionality, and suppression. The lines from a basic geometrical element have become the model of a reductive world based on isolation according to certain criteria such as function, structure, and social organization. Their traces are experienced in the contemporary world as fragments or ruins of a system of domination of an assumed hierarchical unity. How can one release oneself from such dependence or determinism? How can the lines become less “systematic” and forms more autonomous, and less reductive? How is a form released from modernistic determinism on the new controversial ground? How can these elements or forms of representation become forms of action in the present complex world? In this paper, the meaning of lines through the ideas of Le Corbusier, Leonidov, Picasso, and Hitchcock is presented. Spatial research was made through a series of examples arising from the projects of the architectural studio “Residential Transformations”, which was a backbone for mapping the possibilities ranging from playfulness to exactness, as tactics of transformation in the different contexts of the contemporary world.

  17. Extra-Property Legal Reserve in the Cerrado Biome: A preliminary Analysis within the Watershed Context

    Directory of Open Access Journals (Sweden)

    Fábio Carneiro Lobo

    2006-08-01

    Full Text Available This paper presents a normalized remaining vegetation index (NRVI based on land use data, which is evaluated according to three distinct minimum watershed sizes (10,000, 50,000 and 200,000 ha , whose limits were derived via SRTM data (Shuttle Radar Topography Mission. The NRVI varies from -1 (i. e. entirely converted watersheds to 1 (no conversion at all, and allows the association of land use data to numerical variables, such as social development indices. High NRVI values were found in the Northeastern watersheds of Goias State , while negative NRVI values predominated in the Southeastern and Southern portions of the study area. In compliance to the Brazilian Forest Code (i. e. permanent preservation areas and legal reserve, we estimated an NRVI value of -0.382, which is found in only 50,13% of the 10,000 ha watersheds. Although preliminary, our results suggest that NRVI can effectively serve the purposes of a transferable development rights approach (TDR regarding legal reserves in the State of Goias and Federal District.

  18. A two-tiered on-line server-side bandwidth reservation framework for the real-time delivery of multiple video streams

    Science.gov (United States)

    Londoño, Jorge M.; Bestavros, Azer

    2009-01-01

    The advent of virtualization and cloud computing technologies necessitates the development of effective mechanisms for the estimation and reservation of resources needed by content providers to deliver large numbers of video-on-demand (VOD) streams through the cloud. Unfortunately, capacity planning for the QoS-constrained delivery of a large number of VOD streams is inherently difficult as VBR encoding schemes exhibit significant bandwidth variability. In this paper, we present a novel resource management scheme to make such allocation decisions using a mixture of per-stream reservations and an aggregate reservation, shared across all streams to accommodate peak demands. The shared reservation provides capacity slack that enables statistical multiplexing of peak rates, while assuring analytically bounded frame-drop probabilities, which can be adjusted by trading off buffer space (and consequently delay) and bandwidth. Our two-tiered bandwidth allocation scheme enables the delivery of any set of streams with less bandwidth (or equivalently with higher link utilization) than state-of-the-art deterministic smoothing approaches. The algorithm underlying our proposed framework uses three per-stream parameters and is linear in the number of servers, making it particularly well suited for use in an on-line setting. We present results from extensive trace-driven simulations, which confirm the efficiency of our scheme especially for small buffer sizes and delay bounds, and which underscore the significant realizable bandwidth savings, typically yielding losses that are an order of magnitude or more below our analytically derived bounds.

  19. Contact line motion over substrates with spatially non-uniform properties

    Science.gov (United States)

    Ajaev, Vladimir; Gatapova, Elizaveta; Kabov, Oleg

    2017-11-01

    We develop mathematical models of moving contact lines over flat solid surfaces with spatial variation of temperature and wetting properties under the conditions when evaporation is significant. The gas phase is assumed to be pure vapor and a lubrication-type framework is employed for describing viscous flow in the liquid. Marangoni stresses at the liquid surface arise as a result of temperature variation in the vapor phase, non-equilibrium effects during evaporation at the interface, and Kelvin effect. The relative importance of these three factors is determined. Variation of wetting properties is modeled through a two-component disjoining pressure, with the main focus on spatially periodic patterns leading to time-periodic variation of the contact line speed.

  20. Occurrence of Neospora caninum and Toxoplasma gondii antibodies in dogs from rural properties surrounding a biological reserve, Espirito Santo, Brasil

    Directory of Open Access Journals (Sweden)

    Igor da Cunha Lima Acosta

    Full Text Available Abstract The aim of this study was to determine the presence of antibodies to Neospora caninum and Toxoplasma gondii in serum samples of 187 dogs from 30 rural properties surrounding Córrego do Veado Biological Reserve, Espírito Santo State, Brazil. The Reserve is one of the last lowland Atlantic Forest remnants of the region, surrounded by agriculture farms and cattle pastures. The presence of IgG antibodies was determined by the Indirect Fluorescent Antibody Test for T. gondii (cut-off 1:16 and N. caninum (cut-off 1:50. Positive samples were diluted 2-fold until the last positive dilution. Antibodies to T. gondii were found in 77 (47.05% dogs and antibodies to N. caninum in 22 dogs (11.76% and one only dog was positive for both infections. No association between T. gondii and N. caninum infection and sex was observed (p>0.05. Control measures to prevent those infections in dogs that living surrounding the reserve and that had contact with wild animals are important to avoid the introduction of N. caninum in wild animals. This was the first study of frequency of occurrence of T. gondii and N. caninum in dogs from Espírito Santo, Brazil.

  1. Eggshell bacterial load is related to antimicrobial properties of feathers lining barn swallow nests.

    Science.gov (United States)

    Peralta-Sánchez, Juan Manuel; Soler, Juan José; Martín-Platero, Antonio Manuel; Knight, Rob; Martínez-Bueno, Manuel; Møller, Anders Pape

    2014-02-01

    The use of feathers to line bird's nests has traditionally been interpreted as having a thermoregulatory function. Feather-degrading bacteria growing on feathers lining nests may have antimicrobial properties, which may provide an additional benefit to lining nests with feathers. We test the hypothesis that the production of antimicrobial substances by feather bacteria affects the microbiological environment of the nest, and therefore the bacterial density on eggshells and, indirectly, hatching success. These effects would be expected to differ between nests lined with pigmented and white feathers, because bacteria grow differently on feathers of different colors. We experimentally manipulated the composition of pigmented and unpigmented feathers in nests of the barn swallow (Hirundo rustica) and studied the antimicrobial properties against the keratin-degrading bacterium Bacillus licheniformis of bacteria isolated from feathers of each color. Analyzed feathers were collected at the end of the incubation period, and antimicrobial activity was defined as the proportion of bacteria from the feathers that produce antibacterial substances effective against B. licheniformis. Our experimental manipulation affected antimicrobial activity, which was higher in nests with only white feathers at the beginning of incubation. Moreover, white feathers showed higher antimicrobial activity than black ones. Interestingly, antimicrobial activity in feathers of one of the colors correlated negatively with bacterial density on feather of the opposite color. Finally, antimicrobial activity of white feathers was negatively related to eggshell bacterial load. These results suggest that antimicrobial properties of feathers in general and of white feathers in particular affect the bacterial environment in nests. This environment in turn affects the bacterial load on eggshells, which may affect hatching success.

  2. Material property determination of the lining layers of a versatile helmet

    Directory of Open Access Journals (Sweden)

    Kottner Radek

    2018-01-01

    Full Text Available This paper deals with material property identification of a helmet lining consisting of an outer layer of an expanded polystyrene (EPS and inner layer of an open-closed cell foam (OCCF. A combined numerical simulation and experimental testing was used for the material property identification. Compression and drop tests were performed. The ABAQUS finite element commercial code was used for numerical simulations in which the OOCF was modelled as a rate dependent viscoelastic material, while the EPS as a crushable foam. The reaction force time histories coming from the numerical simulation and the experiment have been used as a criterion for material parameter determination. After the identification of the material properties, numerical drop-tests were used to study the behaviour of a plate and a conical composite OOCF and EPS liners to decide which of them suits more for the helmet.

  3. Antioxidant Properties of Seeds from Lines of Artichoke, Cultivated Cardoon and Wild Cardoon

    Directory of Open Access Journals (Sweden)

    Alessandra Durazzo

    2013-06-01

    Full Text Available The artichoke (Cynara cardunculus L. subsp. scolymus L., the cultivated cardoon (Cynara cardunculus var. altilis DC. and the wild cardoon (Cynara cardunculus var. sylvestris L. are species widely distributed in the Mediterranean area. The aim of this research was to evaluate the antioxidant properties of seeds from lines of artichoke and cultivated and wild cardoon in both aqueous-organic extracts and their residues by FRAP (Ferric Reducing Antioxidant Power and TEAC (Trolox Equivalent Antioxidant Capacity evaluations. Both artichoke and cardoon seeds are a good source of antioxidants. Among artichoke seeds, hydrolysable polyphenols contribution to antioxidant properties ranged from 41% to 78% for FRAP values and from 17% to 37% for TEAC values. No difference between cultivated and wild cardoon in antioxidant properties are reported. Our results could provide information about the potential industrial use and application of artichoke and/or cardoon seeds.

  4. Anti-inflammatory properties of an extract of M. ilicifolia in the human intestinal epithelial Caco-2 cell line.

    Science.gov (United States)

    Wonfor, Ruth; Natoli, Manuela; Parveen, Ifat; Beckman, Manfred; Nash, Robert; Nash, Deborah

    2017-09-14

    Maytenus ilicifolia is a Celastracea plant used in traditional medicine to alleviate digestive tract inflammatory disorders. We investigated anti-inflammatory properties of M. ilicifolia crude extract towards Caco-2 cell line, as a model of Toll-like Receptor 2 (TLR-2) inflammatory pathway. Toxicity was assessed following culture of Caco-2 with M. ilicifolia, using apparent cell permeability and trans-epithelial electric resistance. Anti-inflammatory properties of M. ilicifolia were assessed through IL-8 secretion and TLR-2 associated gene expression of Caco-2 cells with or without an LTA challenge. M. ilicifolia was not toxic to Caco-2 cells. M. ilicifolia down-regulated TLR2 expression with and without LTA challenge but had no effect on other genes. Following LTA challenge of Caco-2 cells, 100 and 200µg/mL M. ilicifolia abrogated IL-8 secretion. We provide preliminary data for some M. ilicifolia anti-inflammatory properties. Further research must establish the full extent and mode of action on particular inflammatory pathways. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  5. Investigation of soot optical properties by spectral line-of-sight attenuation

    Energy Technology Data Exchange (ETDEWEB)

    Migliorini, F.; Thomson, K.A.; Smallwood, G.J. [National Research Council of Canada, Ottawa, ON (Canada); Geigle, K.P. [DLR, Stuttgart (Germany). Inst. of Combustion Technology; Johnson, M.J. [Carleton Univ., Ottawa, ON (Canada)

    2009-07-01

    Optical soot diagnostics are a non-intrusive method to measure, understand and hopefully control soot formation. This presentation discussed an investigation of soot optical properties by spectral line-of-sight attenuation. Topics that were presented included optical properties in soot diagnostics; the soot refractive index absorption function E(m); E(m) from the literature; variation of E(m) with wavelength; governing equations; one-dimensional spectral LOSA; the gulder burner; the McKenna burner; zero-dimensional spectral LOSA; relative E(m) for the McKenna burner; and a discussion on relative E(m) in a McKenna flame. It was concluded that future work should include thermophoretic sampling at measurement locations in Gulder and McKenna burner to establish morphology and aging of soot and emission measurements to determine if multi-wavelength pyrometry agrees with multiwavelength attenuation. figs.

  6. Characterization of physical and chemical properties of QLARIVIA-line of deuterium depleted Water

    International Nuclear Information System (INIS)

    Ferdes, Ov. S.; Mladin, C.; Petre, R.M.; Mitu, F.; Costinel, Diana; Vremera, Raluca; Sandru, Claudia

    2008-01-01

    QLARIVIA is the brand-name of Deuterium Depleted Water line of products of drinking water differentiating mainly by the deuterium concentration. It is the result of a national technological transfer project and it is based on an original, patented technology for deuterium depletion from the normal water. The paper presents the measuring and analysis results of the chemical and physical properties of the QLARIVIA brand-line of drinking DDW, as: pH; water hardness; permanganate index; Ca; Mg; Cl - ; SO4 2 - ; NH 4 ; NO 3 - ; NO 2 - , as well as the deuterium concentration determination by mass spectrometry. The analysis has been performed on at least 20 batch-samples, by usual, standardized and/or validated analytical methods, in ISO 17025:2005 accredited laboratories. The results are discussed considering the requirements of the EU directive on drinking water as well as of the Romanian Act on drinking water no. 458/2002 with its supplemental modification by the Act no.363/2004. The conclusion is that QLARIVIA - brand line of drinking DDW fulfills all the official physical and chemical requirements for the drinking water. (authors)

  7. What's in the Wind? Determining the Properties of Outflowing Gas in Powerful Broad Absorption Line Quasars

    Science.gov (United States)

    Leighly, Karen

    2017-08-01

    A significant fraction of quasars exhibits blueshifted broadabsorption lines (BALs) in their rest-UV spectra, indicating powerfuloutflows emerging from the central engine. These outflows may removeangular momentum to enable black hole growth, enrich the intergalacticmedium with metals, and trigger quenching of star formation ingalaxies. Despite years of study, the physical conditions of theoutflowing gas are poorly understood. The handful of objects that havebeen subjected to detailed analysis are atypical and characterized byrelatively narrow lines where blending is unimportant. However,investigating more powerful BAL quasars will give us better insightinto the types of outflows much more likely to impact galaxyevolution.SimBAL is a novel spectral synthesis fitting method for BAL quasarsthat uses Bayesian model calibration to compare synthetic to observedspectra. With the model inputs of ionization parameter, columndensity, and covering fraction specified, the gas properties givingrise to the BAL features can be determined. We propose to applySimBAL to archival spectra of a sample of 14 luminous BAL quasars to characterize their bulk outflow properties as a function of velocityfor the first time. Our results will show the range of parameterstypical of powerful outflows, an essential step towards constrainingthe physics behind quasar winds and thus their impact on theirenvironments.

  8. Students’ Algebraic Thinking Process in Context of Point and Line Properties

    Science.gov (United States)

    Nurrahmi, H.; Suryadi, D.; Fatimah, S.

    2017-09-01

    Learning of schools algebra is limited to symbols and operating procedures, so students are able to work on problems that only require the ability to operate symbols but unable to generalize a pattern as one of part of algebraic thinking. The purpose of this study is to create a didactic design that facilitates students to do algebraic thinking process through the generalization of patterns, especially in the context of the property of point and line. This study used qualitative method and includes Didactical Design Research (DDR). The result is students are able to make factual, contextual, and symbolic generalization. This happen because the generalization arises based on facts on local terms, then the generalization produced an algebraic formula that was described in the context and perspective of each student. After that, the formula uses the algebraic letter symbol from the symbol t hat uses the students’ language. It can be concluded that the design has facilitated students to do algebraic thinking process through the generalization of patterns, especially in the context of property of the point and line. The impact of this study is this design can use as one of material teaching alternative in learning of school algebra.

  9. On-line measurement of mechanical, optical properties and roughness parameters

    Directory of Open Access Journals (Sweden)

    Hartman, H.

    2005-12-01

    Full Text Available On-line measurements become a central importance for the control of production line output. The target is to replace traditional single local destructive quality checks by a continuous survey of the product properties. Other traditional like pyrometric temperature measurements suffer of well-known but non-soluble weakness points. New methods need the unambiguous correlation with the results of traditional testing to be representative for valid proof standards.EKO Stahl GmbH introduces several methods of on-line measurements focused actually on temperature measurement means of FTIR-Spectrometer, prediction of the mechanical properties of steel strips using the information of residual magnetization after a magnetization pulse and optical roughness measurements. The correlation between the results of the new methods and the classical proof processes has been established in a satisfactory manner.

    Las medidas on line van tomando una importancia central para el control de la calidad de la producción . El objetivo es reemplazar las pruebas destructivas puntuales tradicionales por un control continuo de las características del producto. Otros métodos tradicionales, como la medida de la temperatura con pirómetros, adolecen de conocidos pero insolubles puntos débiles. Los nuevos métodos necesitan la correlación inequívoca con los resultados de los métodos corrientes clásicos para obtener la autoridad de un estándar de prueba. La EKO Stahl GmbH ha introducido varios métodos de medidas on line y actualmente concentrados en la medida de la temperatura con espectrómetro FTIR, predicción de las características mecánicas usando la información del magnetismo residual, a partir de un impulso magnético inicial así como la medida óptica de la rugosidad. La correlación entre los resultados de los nuevos métodos y los métodos clásicos ha quedado establecida de manera satisfactoria.

  10. Physical properties of a new denture lining material containing a fluoroalkyl methacrylate polymer.

    Science.gov (United States)

    Hayakawa, Iwao; Akiba, Norihisa; Keh, EnSheng; Kasuga, Yuta

    2006-07-01

    A new fluoride-containing, methacrylate-based denture lining material has been introduced. Because of the fluoride content, this material is expected to demonstrate low water sorption and solubility and high stain resistance, but these attributes remain untested. This study investigated a wide range of clinically relevant properties for a new fluoroalkyl methacrylate denture base liner product (Maxfit) and compared these properties with those of 3 other commercial products. Four denture lining materials were tested: Maxfit, Kooliner, Tokuyama Rebase (fast set), and Denture Liner. Water sorption (microg/mm(3)) and solubility (microg/mm(3)) were tested according to International Organization for Standardization (ISO) Standard No. 1567. Stain resistance was evaluated by measuring color change (DeltaE) after immersion in 2 solutions (coffee and turmeric solution). Microhardness was determined using Knoop indentation testing according to American National Standards Institute/American Dental Association Specification No. 17. Relined denture fit was evaluated by measuring the gap (mm) occurring between the relined denture base and the cast after polymerization. Shear bond strength (MPa) to denture base materials (polymethyl methacrylate, cobalt-chromium alloy, and titanium) was tested according to ISO Standard No. 11405. Data were statistically analyzed using nonparametric Kruskal-Wallis (alpha=.05) and Mann-Whitney U tests combined with the Bonferroni correction (alpha=.008). Maxfit showed the lowest water sorption and solubility (8.0 +/- 0.1, 0.5 +/- 0.1 microg/mm(3), respectively). The color change from coffee immersion of Maxfit was significantly less than Tokuyama Rebase and Denture Liner, and significantly less than Tokuyama Rebase and Denture Liner in a turmeric solution (PDenture Liner (Pdenture liner (Maxfit) showed the lowest water sorption and solubility, and superior stain resistance. In spite of the addition of the fluoride content, this product exhibited no

  11. Gumfooted lines in black widow cobwebs and the mechanical properties of spider capture silk.

    Science.gov (United States)

    Blackledge, Todd A; Summers, Adam P; Hayashi, Cheryl Y

    2005-01-01

    Orb-weaving spiders produce webs using two types of silk that have radically different mechanical properties. The dragline silk used to construct the supporting frame and radii of the web is stiff and as strong as steel, while the capture spiral is much weaker but more than ten times as extensible. This remarkable divergence in mechanical properties has been attributed to the aqueous glue that coats the capture spiral, which is thought to decrease capture spiral stiffness and increase its extensibility. However, discerning the effect of the aqueous glue on fiber performance is complicated because dragline silk and the capture spiral are assembled from different proteins, which may also affect mechanical performance. Here, we use the sticky gumfooted lines of black widow cobwebs to test the effect of the addition of aqueous glue on the mechanical properties of dragline silk. We also surveyed orb-webs spun by a broad range of species for bundles of looped silk. Such bundles, termed windlasses, have been thought to increase capture spiral extensibility by "paying out" additional lengths of silk. Our results suggest that neither plasticization of silk by aqueous glue nor excess silk in windlasses can by themselves account for the remarkable extensibility of orb-weaver capture silk compared to other spider silks. This argues that the unique amino acid motifs of the flagelliform fibroins that constitute the core of the capture spiral play an essential role in capture silk's extreme extensibility.

  12. Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines

    Directory of Open Access Journals (Sweden)

    Chen Lei

    2011-06-01

    Full Text Available Abstract Background Cancer stem cells (CSCs are regarded as the cause of tumor formation and recurrence. The isolation and identification of CSCs could help to develop novel therapeutic strategies specifically targeting CSCs. Methods Human hepatoma cell lines were plated in stem cell conditioned culture system allowed for sphere forming. To evaluate the stemness characteristics of spheres, the self-renewal, proliferation, chemoresistance, tumorigenicity of the PLC/PRF/5 sphere-forming cells, and the expression levels of stem cell related proteins in the PLC/PRF/5 sphere-forming cells were assessed, comparing with the parental cells. The stem cell RT-PCR array was performed to further explore the biological properties of liver CSCs. Results The PLC/PRF/5, MHCC97H and HepG2 cells could form clonal nonadherent 3-D spheres and be serially passaged. The PLC/PRF/5 sphere-forming cells possessed a key criteria that define CSCs: persistent self-renewal, extensive proliferation, drug resistance, overexpression of liver CSCs related proteins (Oct3/4, OV6, EpCAM, CD133 and CD44. Even 500 sphere-forming cells were able to form tumors in NOD/SCID mice, and the tumor initiating capability was not decreased when spheres were passaged. Besides, downstream proteins DTX1 and Ep300 of the CSL (CBF1 in humans, Suppressor of hairless in Drosophila and LAG1 in C. elegans -independent Notch signaling pathway were highly expressed in the spheres, and a gamma-secretase inhibitor MRK003 could significantly inhibit the sphere formation ability. Conclusions Nonadherent tumor spheres from hepatoma cell lines cultured in stem cell conditioned medium possess liver CSC properties, and the CSL-independent Notch signaling pathway may play a role in liver CSCs.

  13. Long-Term Monitoring of the Broad-Line Region Properties in a Selected Sample of AGN

    Directory of Open Access Journals (Sweden)

    Dragana Ilić

    2017-09-01

    Full Text Available We present the results of the long-term optical monitoring campaign of active galactic nuclei (AGN coordinated by the Special Astrophysical Observatory of the Russian Academy of Science. This campaign has produced a remarkable set of optical spectra, since we have monitored for several decades different types of broad-line (type 1 AGN, from a Seyfert 1, double-peaked line, radio loud and radio quiet AGN, to a supermassive binary black hole candidate. Our analysis of the properties of the broad line region (BLR of these objects is based on the variability of the broad emission lines. We hereby give a comparative review of the variability properties of the broad emission lines and the BLR of seven different type 1 AGNs, emphasizing some important results, such as the variability rate, the BLR geometry, and the presence of the intrinsic Baldwin effect. We are discussing the difference and similarity in the continuum and emission line variability, focusing on what is the impact of our results to the supermassive black hole mass determination from the BLR properties.

  14. NOAA Polyline Shapefile - ROV transect Lines, US Caribbean - North East Reserve, Puerto Rico - M-I907-NF-13 (2013), UTM 20N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This shapefile denotes the transect lines of the underwater video and photos that were collected by NOAA scientists using a Spectrum Phantom S2 ROV (remotely...

  15. NOAA Polyline Shapefile - ROV transect Lines, US Caribbean - North East Reserve, Puerto Rico - M-I907-NF-12 (2012), UTM 20N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This shapefile denotes the transect lines of the underwater video and photos that were collected by NOAA scientists using a Spectrum Phantom S2 ROV (remotely...

  16. NOAA Polyline Shapefile - ROV transect Lines, US Caribbean - North East Reserve, Puerto Rico - M-I907-NF-12 (2012), UTM 20N NAD83 (NCEI Accession 0131856)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This shapefile denotes the transect lines of the underwater video and photos that were collected by NOAA scientists using a Spectrum Phantom S2 ROV (remotely...

  17. Mutagenic properties of linuron and chlorbromuron evaluated by means of cytogenetic biomarkers in mammalian cell lines.

    Science.gov (United States)

    Federico, Concetta; Palmieri, Cristina; Pappalardo, Anna Maria; Ferrito, Venera; Pappalardo, Matteo; Librando, Vito; Saccone, Salvatore

    2016-09-01

    Agricultural practices are usually supported by several chemical substances, such as herbicides. Linuron and chlorbromuron are phenylurea herbicides largely used to protect crops from weeds, blocking photosynthesis by inhibition of the photosystem II complex. The former, also commercially known as lorox or afalon, is selectively used to protect bean and French bean plants, fennels, and celeriacs; the second, commercially known as maloran, is selectively used for carrots, peas, potatoes, soy sprouts, and sunflowers. Considering the widespread use of herbicides and, more generally, pesticides, it is important to clarify their involvement on human health, one of them concerning the possible direct or indirect effect on the genome of exposed populations. Here, we show that these herbicides are endowed by mutagenic properties, as demonstrated by an increased number of chromosomal aberrations (CAs) in two exposed Chinese hamster cell lines derived from ovary and epithelial liver, respectively. This was also confirmed by sister chromatid exchange (SCE) and micronucleus (MN) assays. Our present and previously obtained data clearly indicate that phenylurea herbicides must be used with great caution, especially for agricultural workers who use large amounts of herbicides during their work, and particular attention should be given to residues of these herbicides and their involvement in environmental pollution.

  18. Mapping permanent preservation areas and natural forest fragments as subsidy to the registration of legal reserve areas in rural properties

    Directory of Open Access Journals (Sweden)

    Vicente Paulo Soares

    2011-12-01

    Full Text Available The major objective of this work was to identify and quantify forest fragments suitable to be used as private protected land in rural properties located in the São Bartolomeu creek watershed, State of Minas Gerais, Brazil. The methodological procedures included: mapping of 78 forest fragments through the visual interpretation of an Ikonos II satellite image; delineation of Permanent Preservation Areas (PPAs from a hydrographically conditioned digital elevation model and mapping of 292 rural properties through interviews with owners, with the aid of a printed Ikonos II image. The generated maps were overlapped (crossed, allowing the identification of forest fragments that could be used as private protected land in rural property. The result indicated that, from the total of properties evaluated, only 41 (14.04% have more than 20% of forest cover, and therefore, are in condition to attend the environmental law for private protected land.

  19. Mechanical properties of the weld line defect in micro injection molding for various nano filled polypropylene composites

    International Nuclear Information System (INIS)

    Xie Lei; Ziegmann, Gerhard

    2011-01-01

    Research highlights: → PP/CNFs and PP/TiO 2 composites with relative high loading fractions (10, 20, 30 and 35 wt%) were fabricated by inner melt mixing process. Micro tensile test samples were formed by injection molding combined with variotherm process for all composites. → The morphological properties of all nano composites were characterized by WXRD, whose results imply the adding nano fillers did not change the crystal form of PP, but the crystallites size and distance between lattices of crystals were changed with various nano fillers and loading fractions. → DSC analysis show that due to the nucleating function of nano fillers, the peak temperature of crystallization was increased and the peak temperature of crystallization melting was decreased by adding the nanofillers. → The flow ability of nano composites was tested by high pressure single capillary rheometer and the results demonstrate that nano fillers increased the viscosity of PP matrix. → Based on these significant information and analysis foundation of the nano filled composites, the micro weld line samples were formed by injection molding process and characterized by tensile test method. From the achieved results, it can be found that in general, for functional nano filled polymer composites, the mechanical property of micro weld lines were obviously influenced by nano fillers' shape and loading fractions. → The E modulus of micro weld line was increased due to loading CNFs in PP matrix, while the elongation of the micro tensile samples with weld line is considerably decreased comparing with those of unfilled PP samples. The detrimental tensile strength of micro weld lines were observed when CNFs contents increasing, except for at a 10 wt%. → For TiO 2 nano particles filled PP, due to the poor dispersion of nano particles, at low loading fraction of 10 wt%, the E modulus and tensile strength of micro weld lines were decreased by filling nano particles, but when the loading fraction

  20. The Influences of Overlap Length, Bond Line Thickness and Pretreatmant on the Mechanical Properties of Adhesives : Focussing on Bonding Glass

    NARCIS (Netherlands)

    Vervloed, J.; Kwakernaak, A.; Poulis, H.

    2008-01-01

    This paper focuses on the influences of overlap length, bond line thickness and pretreatment on the mechanical properties of adhesive bonds. In order to determine the bond strength, lap shear tests were performed. The researched adhesives are a 2 component epoxy and MS polymer. The smallest overlap

  1. Application of an automatic yarn dismantler to track changes in cotton fibre properties during processing on a miniature spinning line

    CSIR Research Space (South Africa)

    Fassihi, A

    2014-11-01

    Full Text Available This paper reports on the application of a newly developed automatic yarn dismantler for dismantling short staple ring-spun yarns, to track changes in cotton fibre properties from lint to yarn, during processing on a miniature spinning line...

  2. Assessment of metabolic properties and kinetic parameters of methanogenic sludge by on-line methane production rate measurements

    NARCIS (Netherlands)

    Gonzalez-Gil, G.; Kleerebezem, R.; Lettinga, G.

    2002-01-01

    This report presents a new approach to studying the metabolic and kinetic properties of anaerobic sludge from single batch experiments. The two main features of the method are that the methane production is measured on-line with a relatively cheap system, and that the methane production data can be

  3. In vitro acaricidal properties of Semecarpus anacardium fruit and Datura stramonium leaf extracts against acaricide susceptible (IVRI-I line) and resistant (IVRI-V line) Rhipicephalus (Boophilus) microplus.

    Science.gov (United States)

    Ghosh, Srikant; Tiwari, Shashi Shankar; Srivastava, Sharad; Kumar, Sachin; Sharma, Anil Kumar; Nagar, Gaurav; Kumar, K G Ajith; Kumar, Rajesh; Rawat, A K S

    2015-08-01

    In an attempt to identify plants having anti-tick properties, the 95% ethanolic and 50% hydro-ethanolic extracts of the fruits of Semecarpus anacardium and leaves of Datura stramonium were evaluated against reference tick lines of Rhipicephalus (Boophilus) microplus. The 95% ethanolic extracts of S. anacardium and D. stramonium caused 50% and 20% mortality, respectively, within 72 h of treatment by adult immersion test. The LC90 value of the ethanolic fruit extract of S. anacardium was determined as 13.5% (CI 12.05-15.12). The extract was also found efficacious (73.3%±3.3%) against the multi-acaricide-resistant IVRI-V line of R.(B.) microplus. The S. anacardium extract significantly affected the reproductive physiology of treated ticks by inhibiting the oviposition and was found safe. The HPTLC fingerprinting profile revealed the presence of pyrocatechol as a marker compound. The acaricidal property of S. anacardium against chemical acaricide-resistant R. (B.) microplus was discussed. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Scissoring Fault Rupture Properties along the Median Tectonic Line Fault Zone, Southwest Japan

    Science.gov (United States)

    Ikeda, M.; Nishizaka, N.; Onishi, K.; Sakamoto, J.; Takahashi, K.

    2017-12-01

    The Median Tectonic Line fault zone (hereinafter MTLFZ) is the longest and most active fault zone in Japan. The MTLFZ is a 400-km-long trench parallel right-lateral strike-slip fault accommodating lateral slip components of the Philippine Sea plate oblique subduction beneath the Eurasian plate [Fitch, 1972; Yeats, 1996]. Complex fault geometry evolves along the MTLFZ. The geomorphic and geological characteristics show a remarkable change through the MTLFZ. Extensional step-overs and pull-apart basins and a pop-up structure develop in western and eastern parts of the MTLFZ, respectively. It is like a "scissoring fault properties". We can point out two main factors to form scissoring fault properties along the MTLFZ. One is a regional stress condition, and another is a preexisting fault. The direction of σ1 anticlockwise rotate from N170°E [Famin et al., 2014] in the eastern Shikoku to Kinki areas and N100°E [Research Group for Crustral Stress in Western Japan, 1980] in central Shikoku to N85°E [Onishi et al., 2016] in western Shikoku. According to the rotation of principal stress directions, the western and eastern parts of the MTLFZ are to be a transtension and compression regime, respectively. The MTLFZ formed as a terrain boundary at Cretaceous, and has evolved with a long active history. The fault style has changed variously, such as left-lateral, thrust, normal and right-lateral. Under the structural condition of a preexisting fault being, the rupture does not completely conform to Anderson's theory for a newly formed fault, as the theory would require either purely dip-slip motion on the 45° dipping fault or strike-slip motion on a vertical fault. The fault rupture of the 2013 Barochistan earthquake in Pakistan is a rare example of large strike-slip reactivation on a relatively low angle dipping fault (thrust fault), though many strike-slip faults have vertical plane generally [Avouac et al., 2014]. In this presentation, we, firstly, show deep subsurface

  5. Edge Detection and Feature Line Tracing in 3D-Point Clouds by Analyzing Geometric Properties of Neighborhoods

    Directory of Open Access Journals (Sweden)

    Huan Ni

    2016-09-01

    Full Text Available This paper presents an automated and effective method for detecting 3D edges and tracing feature lines from 3D-point clouds. This method is named Analysis of Geometric Properties of Neighborhoods (AGPN, and it includes two main steps: edge detection and feature line tracing. In the edge detection step, AGPN analyzes geometric properties of each query point’s neighborhood, and then combines RANdom SAmple Consensus (RANSAC and angular gap metric to detect edges. In the feature line tracing step, feature lines are traced by a hybrid method based on region growing and model fitting in the detected edges. Our approach is experimentally validated on complex man-made objects and large-scale urban scenes with millions of points. Comparative studies with state-of-the-art methods demonstrate that our method obtains a promising, reliable, and high performance in detecting edges and tracing feature lines in 3D-point clouds. Moreover, AGPN is insensitive to the point density of the input data.

  6. ABL tyrosine kinase inhibition variable effects on the invasive properties of different triple negative breast cancer cell lines.

    Directory of Open Access Journals (Sweden)

    Clément Chevalier

    Full Text Available The non-receptor tyrosine kinase ABL drives myeloid progenitor expansion in human chronic myeloid leukemia. ABL inhibition by the tyrosine kinase inhibitor nilotinib is a first-line treatment for this disease. Recently, ABL has also been implicated in the transforming properties of solid tumors, including triple negative (TN breast cancer. TN breast cancers are highly metastatic and several cell lines derived from these tumors display high invasive activity in vitro. This feature is associated with the activation of actin-rich membrane structures called invadopodia that promote extracellular matrix degradation. Here, we investigated nilotinib effect on the invasive and migratory properties of different TN breast cancer cell lines. Nilotinib decreased both matrix degradation and invasion in the TN breast cancer cell lines MDA-MB 231 and MDA-MB 468. However, and unexpectedly, nilotinib increased by two-fold the invasive properties of the TN breast cancer cell line BT-549 and of Src-transformed fibroblasts. Both display much higher levels of ABL kinase activity compared to MDA-MB 231. Similar effects were obtained by siRNA-mediated down-regulation of ABL expression, confirming ABL central role in this process. ABL anti-tumor effect in BT-549 cells and Src-transformed fibroblasts was not dependent on EGF secretion, as recently reported in neck and squamous carcinoma cells. Rather, we identified the TRIO-RAC1 axis as an important downstream element of ABL activity in these cancer cells. In conclusion, the observation that TN breast cancer cell lines respond differently to ABL inhibitors could have implications for future therapies.

  7. Complementarity of no-take marine reserves and individual transferable catch quotas for managing the line fishery of the great barrier reef.

    Science.gov (United States)

    Little, L R; Grafton, R Q; Kompas, T; Smith, A D M; Punt, A E; Mapstone, B D

    2011-04-01

    Changes in the management of the fin fish fishery of the Great Barrier Reef motivated us to investigate the combined effects on economic returns and fish biomass of no-take areas and regulated total allowable catch allocated in the form of individual transferable quotas (such quotas apportion the total allowable catch as fishing rights and permits the buying and selling of these rights among fishers). We built a spatially explicit biological and economic model of the fishery to analyze the trade-offs between maintaining given levels of fish biomass and the net financial returns from fishing under different management regimes. Results of the scenarios we modeled suggested that a decrease in total allowable catch at high levels of harvest either increased net returns or lowered them only slightly, but increased biomass by up to 10% for a wide range of reserve sizes and an increase in the reserve area from none to 16% did not greatly change net returns at any catch level. Thus, catch shares and no-take reserves can be complementary and when these methods are used jointly they promote lower total allowable catches when harvest is relatively high and encourage larger no-take areas when they are small. ©2010 Society for Conservation Biology.

  8. The Impact of Subway Lines on Residential Property Values in Tianjin: An Empirical Study Based on Hedonic Pricing Model

    Directory of Open Access Journals (Sweden)

    Hui Sun

    2016-01-01

    Full Text Available The construction of subways has an external impact on the urban environment. Among them, the most important acceleration function lies in the property values of housing near subway stations. Tianjin, the largest open coastal city in Northern China, is selected as the subject of the research in this paper by virtue of its unique background. The Hedonic Pricing Model is used in analysing the change in the value of the properties located within 1,000 metres of completed subway line 3 stations. Using the theories of land rent and land location, and a model of the impact of urban traffic on the surrounding real estate prices, we analyse the sphere of influence of Tianjin Metro Line 3 on real estate prices. Finally, the paper stresses the importance of urban construction and subway building and finds that different development strategies should be used according to the characteristics of the subway in various regions of the city.

  9. Indian Reservations

    Data.gov (United States)

    Department of Homeland Security — The TIGER/Line shapefiles and related database files (.dbf) are an extract of selected geographic and cartographic information from the U.S. Census Bureau's Master...

  10. Material property evaluations of bimetallic welds, stainless steel saw fusion lines, and materials affected by dynamic strain aging

    Energy Technology Data Exchange (ETDEWEB)

    Rudland, D.; Scott, P.; Marschall, C.; Wilkowski, G. [Battelle Memorial Institute, Columbus, OH (United States)

    1997-04-01

    Pipe fracture analyses can often reasonably predict the behavior of flawed piping. However, there are material applications with uncertainties in fracture behavior. This paper summarizes work on three such cases. First, the fracture behavior of bimetallic welds are discussed. The purpose of the study was to determine if current fracture analyses can predict the response of pipe with flaws in bimetallic welds. The weld joined sections of A516 Grade 70 carbon steel to F316 stainless steel. The crack was along the carbon steel base metal to Inconel 182 weld metal fusion line. Material properties from tensile and C(T) specimens were used to predict large pipe response. The major conclusion from the work is that fracture behavior of the weld could be evaluated with reasonable accuracy using properties of the carbon steel pipe and conventional J-estimation analyses. However, results may not be generally true for all bimetallic welds. Second, the toughness of austenitic steel submerged-arc weld (SAW) fusion lines is discussed. During large-scale pipe tests with flaws in the center of the SAW, the crack tended to grow into the fusion line. The fracture toughness of the base metal, the SAW, and the fusion line were determined and compared. The major conclusion reached is that although the fusion line had a higher initiation toughness than the weld metal, the fusion-line J-R curve reached a steady-state value while the SAW J-R curve increased. Last, carbon steel fracture experiments containing circumferential flaws with periods of unstable crack jumps during steady ductile tearing are discussed. These instabilities are believed to be due to dynamic strain aging (DSA). The paper discusses DSA, a screening criteria developed to predict DSA, and the ability of the current J-based methodologies to assess the effect of these crack instabilities. The effect of loading rate on the strength and toughness of several different carbon steel pipes at LWR temperatures is also discussed.

  11. A novel rat fibrosarcoma cell line from transformed bone marrow-derived mesenchymal stem cells with maintained in vitro and in vivo stemness properties.

    Science.gov (United States)

    Wang, Meng-Yu; Nestvold, Janne; Rekdal, Øystein; Kvalheim, Gunnar; Fodstad, Øystein

    2017-03-15

    Increasing evidence suggests a possible relationship between mesenchymal stem cells (MSCs) and sarcoma. MSCs are hypothesized to be the cells initiating sarcomagenesis, and cancer stem cells (CSCs) sharing features of MSCs have been identified in sarcomas. Here, we report on the characteristics of a bone marrow-derived rat mesenchymal stem cell line that spontaneously transformed in long-term culture. The rat transformed mesenchymal stem cells (rTMSCs) produced soft-tissue fibrosarcomas in immunocompromised mice and immunocompetent rats. In vitro, the rTMSCs displayed increased proliferation capacity compared to the untransformed cell line. The transformed MSCs maintained the mesenchymal phenotype by expression of the stem cell marker CD 90 and the lack of hematopoietic and endothelial markers. Cytogenetic analysis detected trisomy 6 in the rTMSCs. Side population (SP) isolation and tumorsphere cultivation of the transformed cells confirmed the presence of CSCs among the rTMSCs. Importantly, the rTMSCs retained their differentiation capacity towards osteogenic and adipogenic lineages. This transformed MSC-based cell line may be valuable in examining the balance in a mixed cell population between cancer stem cell properties and the ability to differentiate to specific non-transformed cell populations. Moreover, it may also be a useful tool to evaluate the efficacy of novel targeted immunotherapies in vivo. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Photosynthetic properties of erect leaf maize inbred lines as the efficient photo-model in breeding and seed production

    Directory of Open Access Journals (Sweden)

    Radenović Čedomir N.

    2003-01-01

    Full Text Available The initial idea of this study was a hypothesis that erect leaf maize inbred lines were characterized by properties of an efficient photo-model and that as such were very desirable in increasing the number of plants per area unit (plant density in the process of contemporary selection and seed production. The application of a non-invasive bioluminescence-photosynthetic method, suitable for the efficiency estimation of the photo-model, verified the hypothesis. Obtained photosynthetic properties of observed erect leaf maize inbred lines were based on the effects and characteristics of thermal processes of delayed chlorophyll fluorescence occurring in their thylakoid membranes. The temperature dependence of the delayed chlorophyll fluorescence intensity phase transitions (critical temperatures in the thylakoid membranes and activation energy are the principal parameters of the thermal processes. Based on obtained photosynthetic properties it is possible to select erect leaf maize inbred lines that are resistant and tolerant to high and very high temperatures, as well as, to drought. They could be good and efficient photo-models wherewith.

  13. Mid-IR Properties of an Unbiased AGN Sample of the Local Universe. 1; Emission-Line Diagnostics

    Science.gov (United States)

    Weaver, K. A.; Melendez, M.; Muhotzky, R. F.; Kraemer, S.; Engle, K.; Malumuth. E.; Tueller, J.; Markwardt, C.; Berghea, C. T.; Dudik, R. P.; hide

    2010-01-01

    \\Ve compare mid-IR emission-lines properties, from high-resolution Spitzer IRS spectra of a statistically-complete hard X-ray (14-195 keV) selected sample of nearby (z < 0.05) AGN detected by the Burst Alert Telescope (BAT) aboard Swift. The luminosity distribution for the mid-infrared emission-lines, [O IV] 25.89 microns, [Ne II] 12.81 microns, [Ne III] 15.56 microns and [Ne V] 14.32 microns, and hard X-ray continuum show no differences between Seyfert 1 and Seyfert 2 populations, although six newly discovered BAT AGNs are shown to be under-luminous in [O IV], most likely the result of dust extinction in the host galaxy. The overall tightness of the mid-infrared correlations and BAT luminosities suggests that the emission lines primarily arise in gas ionized by the AGN. We also compared the mid-IR emission-lines in the BAT AGNs with those from published studies of star-forming galaxies and LINERs. We found that the BAT AGN fall into a distinctive region when comparing the [Ne III]/[Ne II] and the [O IV]/[Ne III] quantities. From this we found that sources that have been previously classified in the mid-infrared/optical as AGN have smaller emission line ratios than those found for the BAT AGNs, suggesting that, in our X-ray selected sample, the AGN represents the main contribution to the observed line emission. Overall, we present a different set of emission line diagnostics to distinguish between AGN and star forming galaxies that can be used as a tool to find new AGN.

  14. Effects of sterilization with hydrogen peroxide gas plasma, ethylene oxide, and steam on bioadhesive properties of nylon and polyethylene lines used for stabilization of canine stifle joints.

    Science.gov (United States)

    Gatineau, Matthieu; El-Warrak, Alexander O; Bolliger, Christian; Mourez, Michael; Berthiaume, Frederic

    2012-10-01

    To compare effects of sterilization with hydrogen peroxide gas plasma (HPGP), ethylene oxide, and steam on bioadhesive properties of nylon and polyethylene lines used for stabilization of canine stifle joints. Samples of a 36.3-kg test nylon leader line, 57.8-kg test nylon fishing line, and 2-mm ultrahigh-molecular weight polyethylene (UHMWPE) were used. In this in vitro study, samples of nylon leader line, fishing line, and UHMWPE sterilized by use of HPGP, ethylene oxide, and steam or unsterilized samples were used. Bacterial adherence on unsterilized and sterilized samples was tested with Staphylococcus epidermidis and Escherichia coli. Five samples were examined for each line type and sterilization condition, and final colony counts were obtained. Bacterial adherence was significantly affected by method of sterilization for all 3 line types. For most of the samples, bacterial adherence was similar or lower when HPGP sterilization was used, compared with results for sterilization via ethylene oxide and steam, respectively. Bacterial adherence was significantly higher for UHMWPE, compared with adherence for the nylon line, regardless of the sterilization method used. Bacterial adherence was higher for nylon fishing line than for nylon leader line for S epidermidis after ethylene oxide sterilization and for E coli after HPGP and ethylene oxide sterilization. Effects of HPGP sterilization on bioadhesive properties of nylon and polyethylene lines compared favorably with those for ethylene oxide and steam sterilization. Also, nylon line may be a more suitable material than UHMWPE for suture prostheses on the basis of bacterial adherence properties.

  15. Sensing soil properties in the laboratory, in situ, and on-Line: A review

    NARCIS (Netherlands)

    Kuang, B.; Mahmood, H.S.; Quraishi, Z.; Hoogmoed, W.B.; Mouazen, A.M.; Henten, van E.

    2012-01-01

    Since both the spatial and vertical heterogeneities in soil properties have an impact on crop growth and yield, accurate characterization of soil properties at high sampling resolution is a preliminary step in successful management of soil-water-plant system. Conventional soil sampling and analyses

  16. Inflammatory response and barrier properties of a new alveolar type 1-like cell line (TT1).

    NARCIS (Netherlands)

    Bogaard, E.H.J. van den; Dailey, L.A.; Thorley, A.J.; Tetley, T.D.; Forbes, B.

    2009-01-01

    PURPOSE: To evaluate the inflammatory response and barrier formation of a new alveolar type 1-like (transformed type I; TT1) cell line to establish its suitability for toxicity and drug transport studies. METHODS: TT1 and A549 cells were challenged with lipopolysaccharide (LPS). Secretion of

  17. Infrared and optical properties of the emission-line galaxies NGC 1386 and NGC 1365

    International Nuclear Information System (INIS)

    Phillips, M.M.; Frogel, J.A.

    1980-01-01

    We have obtained optical spectrophotometry and broad-band infrared data for the nucleus of the emission-line galaxy NGC 1386. These observations are discussed and compared with our own optical spectrophotometry as well as published optical and infrared measurements of the nucleus of the neighboring ''hot spot'' galaxy NGC 1365. Both galaxies show large infared excesses. The very high excitation emission-line spectrum of NGC 1386 is that of a type of 2 Seyfert, making this galaxy the closest known member of this class of objects. We find direct evidence for a significant early-type stellar population in the nucleus of NGC 1365, thus strengthening the previous conclusion that the nuclear emission lines of this galaxy are excited by the radiation of young, hot stars. In addition, we confirm the presence of weak [Ne V] and He II emission, which suggests that a nonthermal source of ionization may also be present. The nucleus of NGC 1365 is emitting a factor of 10 more energy in both the optical emission lines and the infrared than is that of NGC 1386. Finally, we point out the uncertainty in identification of NGC 1365 as an X-ray source in view of its proximity of a Seyfert 2, galaxy, several of which have now been shown to be strong X-ray emitters

  18. A line array based near field imaging technique for characterising acoustical properties of elongated targets

    NARCIS (Netherlands)

    Driessen, F.P.G.

    1995-01-01

    With near field imaging techniques the acoustical pressure waves at distances other than the recorded can be calculated. Normally, acquisition on a two dimensional plane is necessary and extrapolation is performed by a Rayleigh integral. A near field single line instead of two dimensional plane

  19. A study on properties-performances of coated particle fuel and on-line DB establishment

    International Nuclear Information System (INIS)

    Kim, Yong Soo; Lee, Hyo Cheol; Jang, Jeong Nam; Kwon, Seok Hwan

    2007-03-01

    Recently national project for HTGR for hydrogen production has been kicked off. However, For the successful development of the high temperature gas cooled reactor high temperature and burn-up dependent properties of the reactor materials are essentially and crucially required. Therefore, it was proposed to build up the materials properties and fuel performance data base. In this study, a phase - 1 properties and performance DB for coated particle fuel was developed. This database report consists two sections: materials properties and fuel performance. The materials properties has three parts: kernel materials, carbide coating materials, and fuel elements and graphite matrix. UO2 and UCO belong to kernel materials while PyC, SiC, and ZrC comprises the coating materials section. Thermal, mechanical and physical properties data of these materials were collected, reviewed, and summarized. Additionally, the property change induced by manufacture process and irradiation were reviewed. Fuel performance data were also collected, reviewed, and analyzed based on the key phenomena and failure mechanism, These performance data are divided into two: normal and accident. All of these data will be accessible in the pc based stand-alone system. These results will be directly used for HTGR fuel design and fabrication and preliminary fuel performance analysis under irradiation

  20. ANALYSIS OF THERMAL PROPERTIES OF THE LED-LINES BY METHOD OF ELECTRICАL TRANSIENT PROCESSES

    Directory of Open Access Journals (Sweden)

    S. A. Manеgo

    2015-01-01

    Full Text Available Increasing the solid lighting facilities operational energy-efficiency in the national economy of the Republic of Belarus is of current concern. The modern problems of energy-saving lighting are multifaceted and broad-ranging. It is particularly burning amidst the energy crisis and the world commercial slump. Thus, the lighting demands 10–13 % of the total electric energy consumption in Belarus. That is to say, there is a significant potential of energy saving in transition to energy-efficient lighting. The paper considers the issues of reliability and service period of the solid-state lighting devices created on the basis of lines of light-emitting-diodes (LED produced by Paragon Semiconductor Lighting Technology Co., Ltd. The optoelectronic apparatuses reliability assessment is based on investigation of the development principles and deterioration mechanisms leading to failures of one kind or another. The deterioration causes ascertainment is indispensable for acting upon them later on and thus reducing the degradation speed and extent. One of the LED-devices deterioration main sources is the temperature overheat of the LED-chip active area. Therefore, techniques for evaluating the heat characteristics of solid lighting devices become the issue of the day. The article investigates thermal properties of high-capacity blue LED-lines by method of electrical transient processes. The authors calculate temperatures in the LED-lines active areas at various heat-dissipation conditions and injection currents values. They realize computer generated simulation of the heated lines thermal fields applying the ANSYS packet. The study concludes that out of the degree of temperature-distribution heterogeneity along the line impossibility of the line chip structural units thermal characteristics extraction arises based on all LEDs homogenized over the line temperature-time dependences. The paper indicates that one can with reasonable accuracy obtain the LED-lines

  1. Properties of laser-produced GaAs plasmas measured from highly resolved X-ray line shapes and ratios

    Science.gov (United States)

    Seely, J. F.; Fein, J.; Manuel, M.; Keiter, P.; Drake, P.; Kuranz, C.; Belancourt, Patrick; Ralchenko, Yu.; Hudson, L.; Feldman, U.

    2018-03-01

    The properties of hot, dense plasmas generated by the irradiation of GaAs targets by the Titan laser at Lawrence Livermore National Laboratory were determined by the analysis of high resolution K shell spectra in the 9 keV to 11 keV range. The laser parameters, such as relatively long pulse duration and large focal spot, were chosen to produce a steady-state plasma with minimal edge gradients, and the time-integrated spectra were compared to non-LTE steady state spectrum simulations using the FLYCHK and NOMAD codes. The bulk plasma streaming velocity was measured from the energy shifts of the Ga He-like transitions and Li-like dielectronic satellites. The electron density and the electron energy distribution, both the thermal and the hot non-thermal components, were determined from the spectral line ratios. After accounting for the spectral line broadening contributions, the plasma turbulent motion was measured from the residual line widths. The ionization balance was determined from the ratios of the He-like through F-like spectral features. The detailed comparison of the experimental Ga spectrum and the spectrum simulated by the FLYCHK code indicates two significant discrepancies, the transition energy of a Li-like dielectronic satellite (designated t) and the calculated intensity of a He-like line (x), that should lead to improvements in the kinetics codes used to simulate the X-ray spectra from highly-charged ions.

  2. Conducting properties of classical transmission lines with Ornstein-Uhlenbeck type disorder

    International Nuclear Information System (INIS)

    Lazo, E.; Diez, E.

    2011-01-01

    In this work we study the behavior of bands of extended states and localized states which appear in classical disordered electrical transmission lines, when we use a ternary map and the Ornstein-Uhlenbeck process to generate the long-range correlated disorder, instead of using the Fourier filtering method. By performing finite-size scaling we obtain the asymptotic value of the map parameter b in the thermodynamic limit in a selected range of values of the parameters γ and C of the Ornstein-Uhlenbeck process. With these data we obtain the phase diagrams which separate the localized states from the extended states. These are the fundamental results of this article. - Highlights: → We study disordered classical transmission lines. → We use the Ornstein-Uhlenbeck process to generate long-range correlated disorder. → We obtain the phase diagram of the transition in the thermodynamic limit.

  3. Study of the mechanical properties of hybrid composite basalt / alumina / shells for brake lining pads

    Science.gov (United States)

    Adi Atmika, I. K.; Ary Subagia, IDG.; Surata, I. W.; Sutantra, I. N.

    2017-05-01

    Brake lining pad as one of the active safety components in motor vehicles has been studied thoroughly. Asbestos is the main material forming the brake in addition to other alloy materials that have a negative impact on health and the environment. This paper explain the behavior of hybrid composites phenolic resin with basalt/alumina/clamshell powder reinforced on brake lining pad. This materials has been manufactured use compaction and sintering process through any steps, that an emphasis of 2,000 kg for 30 minutes at a constant temperature of 150° C. The research aims to investigate hardness characteristic of hybrid composite that test using the vickers according to standard ASTM E-384. The reinforced materials and phenolic resin composition is 60%: 40%. The results show for the average hardness VHN to 24.18, 25.11, 26.34, 27.21 and 28.83. The average hardness hybrid composite shows the hardness harder than asbestos materials.

  4. Occurrence and Global Properties of Narrow CIV lambda 1549 Absorption Lines in Moderate-Redshift Quasars

    DEFF Research Database (Denmark)

    Vestergaard, Marianne

    2003-01-01

    A statistical study is presented of (a) the frequency of narrow CIV lambda 1549 absorption lines in 1.5 ~50%) of narrow CIV absorbers is detected for the radio-quiet and radio-loud quasars, and a constant ~25% of all the quasars, irrespective of radio type display associated CIV absorbers stronger...... than a rest equivalent width of 0.5A. Both radio-quiet and radio-loud quasars with narrow absorption lines have systematically redder continua, especially strongly absorbed objects. There is evidence of inclination dependent dust reddening and absorption for the radio quasars. An additional key result...... is that the most strongly absorbed radio quasars have the largest radio source extent. This result is in stark contrast to a recent study of the low-frequency selected Molonglo survey in which a connection between the strength of the narrow absorbers and the (young) age of the radio source has been proposed...

  5. Detailed properties of magnetospheric line radiation events observed by the DEMETER spacecraft

    Czech Academy of Sciences Publication Activity Database

    Němec, F.; Parrot, M.; Santolík, Ondřej

    2012-01-01

    Roč. 117, A5 (2012), A05210/1-A05210/9 ISSN 0148-0227 R&D Projects: GA ČR GA205/09/1253; GA MŠk ME09107 Institutional support: RVO:68378289 Keywords : magnetospheric line radiation * electromagnetic waves Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 3.174, year: 2012 http://onlinelibrary.wiley.com/doi/10.1029/2012JA017517/abstract

  6. Properties of prominence fine-structure threads derived from SOHO/SUMER hydrogen Lyman lines

    Czech Academy of Sciences Publication Activity Database

    Gunár, Stanislav; Heinzel, Petr; Schmieder, B.; Schwartz, Pavol; Anzer, U.

    2007-01-01

    Roč. 472, č. 3 (2007), s. 929-936 ISSN 0004-6361 R&D Projects: GA ČR GA205/07/1100 Grant - others:EU(XE) ESA-PECS project No. 98030 Institutional research plan: CEZ:AV0Z10030501 Source of funding: V - iné verejné zdroje Keywords : Sun: prominences * radiative transfer * line: profiles Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.259, year: 2007

  7. A simplified Katsevich algorithm motivated by the distribution properties of k-lines.

    Science.gov (United States)

    Qiao, Zhiwei; Redler, Gage; Halpern, Howard

    2013-10-02

    The Katsevich algorithm is a breakthrough in the theoretically exact algorithms for helical cone beam CT. For future application in medical and industrial CT, determining how to implement it efficiently and accurately is the main task. We analyzed the slope law and intersection law of the k-lines, finding that the k-lines are not intersecting if the half maximal fan angle (HMFA) is less than 21° (numerical solution, so it is approximate) and that the helical pitch and HMFA determine the depth of parallelism of k-lines. Using an appropriate pitch and a HWFA that is less than 21°, one can use a simplified Katsevich algorithm, whose filtration process can be done on the rows of the detector panel so that the pre-weighting, pre-rebinning, post-rebinning and post-weighting steps are all canceled. Simulation experiments show that the simplified algorithm can obtain highly precise images at a faster speed. Our results are intended to be valuable to those who are working on efficient implementations of the Katsevich-type algorithms.

  8. Large-Scale Environment Properties of Narrow-Line Seyfert 1 Galaxies at z < 0.4

    International Nuclear Information System (INIS)

    Järvelä, Emilia; Lähteenmäki, A.; Lietzen, H.

    2017-01-01

    The large-scale environment is believed to affect the evolution and intrinsic properties of galaxies. It offers a new perspective on narrow-line Seyfert 1 galaxies (NLS1) which have not been extensively studied in this context before. We study a large and diverse sample of 960 NLS1 galaxies using a luminosity-density field constructed using Sloan Digital Sky Survey. We investigate how the large-scale environment is connected to the properties of NLS1 galaxies, especially their radio loudness. Furthermore, we compare the large-scale environment properties of NLS1 galaxies with other active galactic nuclei (AGN) classes, for example, other jetted AGN and broad-line Seyfert 1 (BLS1) galaxies, to shed light on their possible relations. In general NLS1 galaxies reside in less dense large-scale environments than any of our comparison samples, thus supporting their young age. The average luminosity-density and distribution to different luminosity-density regions of NLS1 sources is significantly different compared to BLS1 galaxies. This contradicts the simple orientation-based unification of NLS1 and BLS1 galaxies, and weakens the hypothesis that BLS1 galaxies are the parent population of NLS1 galaxies. The large-scale environment density also has an impact on the intrinsic properties of NLS1 galaxies; the radio loudness increases with the increasing luminosity-density. However, our results suggest that the NLS1 population is indeed heterogeneous, and that a considerable fraction of them are misclassified. We support a suggested description that the traditional classification based on the radio loudness should be replaced with the division to jetted and non-jetted sources.

  9. Large-Scale Environment Properties of Narrow-Line Seyfert 1 Galaxies at z < 0.4

    Energy Technology Data Exchange (ETDEWEB)

    Järvelä, Emilia [Metsähovi Radio Observatory, Aalto University, Espoo (Finland); Department of Electronics and Nanoengineering, Aalto University, Espoo (Finland); Lähteenmäki, A. [Metsähovi Radio Observatory, Aalto University, Espoo (Finland); Department of Electronics and Nanoengineering, Aalto University, Espoo (Finland); Tartu Observatory, Tõravere (Estonia); Lietzen, H., E-mail: emilia.jarvela@aalto.fi [Tartu Observatory, Tõravere (Estonia)

    2017-11-30

    The large-scale environment is believed to affect the evolution and intrinsic properties of galaxies. It offers a new perspective on narrow-line Seyfert 1 galaxies (NLS1) which have not been extensively studied in this context before. We study a large and diverse sample of 960 NLS1 galaxies using a luminosity-density field constructed using Sloan Digital Sky Survey. We investigate how the large-scale environment is connected to the properties of NLS1 galaxies, especially their radio loudness. Furthermore, we compare the large-scale environment properties of NLS1 galaxies with other active galactic nuclei (AGN) classes, for example, other jetted AGN and broad-line Seyfert 1 (BLS1) galaxies, to shed light on their possible relations. In general NLS1 galaxies reside in less dense large-scale environments than any of our comparison samples, thus supporting their young age. The average luminosity-density and distribution to different luminosity-density regions of NLS1 sources is significantly different compared to BLS1 galaxies. This contradicts the simple orientation-based unification of NLS1 and BLS1 galaxies, and weakens the hypothesis that BLS1 galaxies are the parent population of NLS1 galaxies. The large-scale environment density also has an impact on the intrinsic properties of NLS1 galaxies; the radio loudness increases with the increasing luminosity-density. However, our results suggest that the NLS1 population is indeed heterogeneous, and that a considerable fraction of them are misclassified. We support a suggested description that the traditional classification based on the radio loudness should be replaced with the division to jetted and non-jetted sources.

  10. Large-Scale Environment Properties of Narrow-Line Seyfert 1 Galaxies at z < 0.4

    Science.gov (United States)

    Järvelä, Emilia; Lähteenmäki, A.; Lietzen, H.

    2017-11-01

    The large-scale environment is believed to affect the evolution and intrinsic properties of galaxies. It offers a new perspective on narrow-line Seyfert 1 galaxies (NLS1) which have not been extensively studied in this context before. We study a large and diverse sample of 960 NLS1 galaxies using a luminosity-density field constructed using Sloan Digital Sky Survey. We investigate how the large-scale environment is connected to the properties of NLS1 galaxies, especially their radio loudness. Furthermore, we compare the large-scale environment properties of NLS1 galaxies with other active galactic nuclei (AGN) classes, for example, other jetted AGN and broad-line Seyfert 1 (BLS1) galaxies, to shed light on their possible relations. In general NLS1 galaxies reside in less dense large-scale environments than any of our comparison samples, thus supporting their young age. The average luminosity-density and distribution to different luminosity-density regions of NLS1 sources is significantly different compared to BLS1 galaxies. This contradicts the simple orientation-based unification of NLS1 and BLS1 galaxies, and weakens the hypothesis that BLS1 galaxies are the parent population of NLS1 galaxies. The large-scale environment density also has an impact on the intrinsic properties of NLS1 galaxies; the radio loudness increases with the increasing luminosity-density. However, our results suggest that the NLS1 population is indeed heterogeneous, and that a considerable fraction of them are misclassified. We support a suggested description that the traditional classification based on the radio loudness should be replaced with the division to jetted and non-jetted sources.

  11. Generation and properties of a new human ventral mesencephalic neural stem cell line

    International Nuclear Information System (INIS)

    Villa, Ana; Liste, Isabel; Courtois, Elise T.; Seiz, Emma G.; Ramos, Milagros; Meyer, Morten; Juliusson, Bengt; Kusk, Philip; Martinez-Serrano, Alberto

    2009-01-01

    Neural stem cells (NSCs) are powerful research tools for the design and discovery of new approaches to cell therapy in neurodegenerative diseases like Parkinson's disease. Several epigenetic and genetic strategies have been tested for long-term maintenance and expansion of these cells in vitro. Here we report the generation of a new stable cell line of human neural stem cells derived from ventral mesencephalon (hVM1) based on v-myc immortalization. The cells expressed neural stem cell and radial glia markers like nestin, vimentin and 3CB2 under proliferation conditions. After withdrawal of growth factors, proliferation and expression of v-myc were dramatically reduced and the cells differentiated into astrocytes, oligodendrocytes and neurons. hVM1 cells yield a large number of dopaminergic neurons (about 12% of total cells are TH + ) after differentiation, which also produce dopamine. In addition to proneural genes (NGN2, MASH1), differentiated cells show expression of several genuine mesencephalic dopaminergic markers such as: LMX1A, LMX1B, GIRK2, ADH2, NURR1, PITX3, VMAT2 and DAT, indicating that they retain their regional identity. Our data indicate that this cell line and its clonal derivatives may constitute good candidates for the study of development and physiology of human dopaminergic neurons in vitro, and to develop tools for Parkinson's disease cell replacement preclinical research and drug testing.

  12. Evaluation of thermal properties of food materials at high pressures using a dual-needle line-heat-source method.

    Science.gov (United States)

    Zhu, S; Ramaswamy, H S; Marcotte, M; Chen, C; Shao, Y; Le Bail, A

    2007-03-01

    Thermal properties of food systems at high pressure (HP) are important in the design and operation of HP processing equipment. Available techniques for thermal property evaluation under HP conditions are still very limited. In this study, a dual-needle line-heat-source (DNL) device was installed in an HP vessel to evaluate thermal conductivity (k), diffusivity (alpha), and volumetric heat capacity (C(pV)) of foods at high pressure. The DNL probe was calibrated using glycerin (0.1 MPa) and 2% (w/w) agar gel (0.1 to 350 MPa) at 5 and 25 degrees C. Calibration results showed a good correlation with the reference data of pure water: R(2)= 0.966 for thermal conductivity and R(2)= 0.837 for diffusivity, and a small standard deviation of relative error (3.18%) for the volumetric heat capacity. Fresh potato and cheddar cheese were used as test samples at 5 degrees C at selected pressure levels (0.1 to 350 MPa). The potato samples gave thermal properties very close to those of pure water, but much higher than those of the cheese. The k and alpha values of both potato and cheese increased with pressure and a 2nd-order polynomial well fitted their pressure dependency. The volumetric heat capacity data did not show a clear pressure-dependency trend. The experimental system worked well for the evaluation of thermal properties at pressures up to 350 MPa.

  13. Generation and properties of a new human ventral mesencephalic neural stem cell line

    DEFF Research Database (Denmark)

    Villa, Ana; Liste, Isabel; Courtois, Elise T

    2009-01-01

    Neural stem cells (NSCs) are powerful research tools for the design and discovery of new approaches to cell therapy in neurodegenerative diseases like Parkinson's disease. Several epigenetic and genetic strategies have been tested for long-term maintenance and expansion of these cells in vitro....... Here we report the generation of a new stable cell line of human neural stem cells derived from ventral mesencephalon (hVM1) based on v-myc immortalization. The cells expressed neural stem cell and radial glia markers like nestin, vimentin and 3CB2 under proliferation conditions. After withdrawal...... derivatives may constitute good candidates for the study of development and physiology of human dopaminergic neurons in vitro, and to develop tools for Parkinson's disease cell replacement preclinical research and drug testing....

  14. [Biologically active fragment of the differentiation factor from HL-60 cell line. Identification and properties].

    Science.gov (United States)

    Kostanian, I A; Astapova, M V; Navolotskaia, E V; Lepikhova, T N; Dranitsyna, S M; Telegin, G B; Rodionov, I L; Baĭdakova, L K; Zolotarev, Iu A; Molotkovskaia, I M; Lipkin, V M

    2000-07-01

    Six-membered peptide fragment TGENHR (HLDF-6) was identified in the HL-60 cell culture of human promyelocyte leukemia treated with retinoic acid when studying the differentiation factor HLDF of this cell line. HLDF-6 retains the ability of the full-size factor to induce the differentiation and arrest the proliferation of the starting HL-60 cells. It was shown that the synthetic peptide HLDF-6 has no specific receptors on the surface of the HL-60 cells but can affect the binding of interleukin IL-1 beta, a cytokine involved in proliferation, to the cell surface. It was found on a model of transplantable NSO myeloma that HLDF-6 has an antitumor activity.

  15. Electrocatalytic property of PtBi and PtPb line compounds via DFT

    Science.gov (United States)

    Wang, Lin-Lin; Johnson, D. D.

    2007-03-01

    A major obstacle to practical, mass market fuel cell (e.g. hydrogen and direct methanol) technology is CO poisoning of Pt anode. Pt alloys, such as disordered PtxRu(1-x), are known to have an increased CO-tolerance. There has been significant effort to understand the mechanism for increased CO- tolerance and to design better catalyst via alloyed nanoparticles and surface alloys. Alternatively, Pt intermetallic compounds, such as with Bi and Pb, have been observed to improve dramatically the CO-tolerance. [E. Casado- Rivera et al. ChemPhysChem 4, 193 (2003) and J. Am. Chem. Soc. 126, 4043 (2004)] Here we use density functional theory to study the adsorptions of CO, H and OH on these materials. We find that (100) and (110) surfaces of PtBi and PtPb line compounds have lower cleavage energy than (001) surface. Adsorption energies and electronic structure are examined to explain the increased CO-tolerance.

  16. Physical and morphological properties of z ~ 3 Lyman break galaxies: dependence on Lyα line emission

    Science.gov (United States)

    Pentericci, L.; Grazian, A.; Scarlata, C.; Fontana, A.; Castellano, M.; Giallongo, E.; Vanzella, E.

    2010-05-01

    Aims: We investigate the physical and morphological properties of Lyman break galaxies (LBGs) at redshift ~2.5 to ~3.5, to determine if and how they depend on the nature and strength of the Lyα emission. Methods: We selected U-dropout galaxies from the z-detected GOODS-MUSIC catalog by adapting the classical Lyman break criteria on the GOODS filter set. We kept only those galaxies with spectroscopic confirmation, mainly from VIMOS and FORS public observations. Using the full multi-wavelength 14-bands information (U to IRAC), we determined the physical properties of the galaxies through a standard spectral energy distribution fitting procedure with the updated Charlot & Bruzual (2009) templates. We also added other relevant observations of the GOODS field, i.e. the 24 μm observations from Spitzer/MIPS and the 2 MSec Chandra X-ray observations. Finally, using non parametric diagnostics (Gini, Concentration, Asymmetry, M20 and ellipticity), we characterized the rest-frame UV morphologies of the galaxies. We then analyzed how these physical and morphological properties correlate with the presence of the Lyα emission line in the optical spectra. Results: We find that unlike at higher redshift, the dependence of physical properties on the Lyα line is milder: galaxies without Lyα in emission tend to be more massive and dustier than the rest of the sample, but all other parameters, ages, star formation rates (SFR), X-ray emission and UV morphology do not depend strongly on the presence of the Lyα emission. A simple scenario where all LBGs have intrinsically high Lyα emission, but where the dust and neutral hydrogen content (which shapes the final appearance of the Lyα) depend on the mass of the galaxies, is able to reproduce the majority of the observed properties at z˜3. Some modification might be needed to account for the observed evolution of these properties with cosmic epoch, which is also discussed.

  17. Nutraceutical properties of cumin residue generated from Ayurvedic industries using cell line models

    OpenAIRE

    Arun, K. B.; Aswathi, U.; Venugopal, V. V.; Madhavankutty, T. S.; Nisha, P.

    2016-01-01

    Spent cumin (SC), generated from Ayurvedic industry, was evaluated for its nutraceutical potential in terms of antioxidant, antidiabetic and anticancer properties, and compared with that of the raw cumin (RC). SC and RC seeds were extracted with ethyl acetate (E) and methanol (M). SCM (methanol extract) were rich in p-coumaric acid, ferulic acid, ellagic acid and cinnamic acid (6.4445, 5.8286, 2.1519, 4.3085 mg/g dry extract). SCM reduced Fe2+ ion (89.68 µM AA/g dry weight), scavenged DPPH ra...

  18. Assessment of aquifer properties, evapotranspiration, and the effects of ditching in the Stoney Brook watershed, Fond du Lac Reservation, Minnesota, 2006-9

    Science.gov (United States)

    Jones, Perry M.; Tomasek, Abigail A.

    2015-01-01

    The U.S. Geological Survey, in cooperation with the Fond du Lac Band of Lake Superior Chippewa, assessed hydraulic properties of geologic material, recharge, and evapotranspiration, and the effects of ditching on the groundwater resources in the Stoney Brook watershed in the Fond du Lac Reservation. Geologic, groundwater, and surface-water data were collected during 2006–9 to estimate hydrologic properties in the watershed. Streamflow and groundwater levels in the shallow glacial deposits in the Stoney Brook watershed were analyzed to estimate groundwater-flow directions, groundwater recharge, and evapotranspiration within the watershed and to assess the effect of ditches on surrounding groundwater resources. Groundwater, streamflow, and precipitation data collected during the study (2006–9) can be used to update the U.S. Department of Agriculture’s Natural Resource Conservation Service and Fond du Lac Resource Management Division surface-water models, which are used to evaluate the effect of proposed adjustments to the ditching system on streamflow on wild rice production and aquatic habitats.

  19. Effect of ageing and immersion in different beverages on properties of denture lining materials

    Directory of Open Access Journals (Sweden)

    Vanessa M. F. Leite

    2010-08-01

    Full Text Available OBJECTIVES: To evaluate the color stability and hardness of two denture liners obtained by direct and indirect techniques, after thermal cycling and immersion in beverages that can cause staining of teeth. MATERIAL AND METHODS: Seventy disc-shaped specimens (18 x 3 mm processed by direct (DT and indirect techniques (IT were made from Elite soft (n=35 and Kooliner (n=35 denture liners. For each material and technique, 10 specimens were subjected to thermal cycling (3,000 cycles and 25 specimens were stored in water, coffee, tea, soda and red wine for 36 days. The values of color change, Shore A hardness (Elite soft and Knoop hardness (Kooliner were obtained. The data were subjected to ANOVA, Tukey's multiple-comparison test, and Kruskal-Wallis test (P<0.05. RESULTS: The thermal cycling promoted a decrease on hardness of Kooliner regardless of the technique used (Initial: 9.09± 1.61; Thermal cycling: 7.77± 1.47 and promoted an increase in the hardness in the DT for Elite Soft (Initial: 40.63± 1.07; Thermal cycling: 43.53± 1.03; hardness of Kooliner (DT: 8.76± 0.95; IT: 7.70± 1.62 and Elite Soft (DT: 42.75± 1.54; IT=39.30± 2.31 from the DT suffered an increase after the immersion in the beverages. The thermal cycling promoted color change only for Kooliner in the IT. Immersion in the beverages did not promote color change for Elite in both techniques. The control group of the DT of Kooliner showed a significant color change. Wine and coffee produced the greatest color change in the DT only for Elite Soft when compared to the other beverages. CONCLUSION: The three variation factors promoted alteration on hardness and color of the tested denture lining materials.

  20. Nutraceutical properties of cumin residue generated from Ayurvedic industries using cell line models.

    Science.gov (United States)

    Arun, K B; Aswathi, U; Venugopal, V V; Madhavankutty, T S; Nisha, P

    2016-10-01

    Spent cumin (SC), generated from Ayurvedic industry, was evaluated for its nutraceutical potential in terms of antioxidant, antidiabetic and anticancer properties, and compared with that of the raw cumin (RC). SC and RC seeds were extracted with ethyl acetate (E) and methanol (M). SCM (methanol extract) were rich in p-coumaric acid, ferulic acid, ellagic acid and cinnamic acid (6.4445, 5.8286, 2.1519, 4.3085 mg/g dry extract). SCM reduced Fe 2+ ion (89.68 µM AA/g dry weight), scavenged DPPH radical (IC 50 -238.6 µg/mL), better α-amylase inhibition (IC 50 -337.22 µg/mL) and glucose uptake activity in 30.7% of L6 cells. SCM inhibited viability, retarded migration area up to 41.02%, arrested cell cycle at S phase and induced apoptosis in 2.45% of HT29 colon cancer cells. The results indicated that dietary interventions using nutraceutical food formulation made out of SC can play a significant role in the prevention and management of degenerative diseases.

  1. Distrinution and properties of nuclides in fission by means of on-line isotope separation

    International Nuclear Information System (INIS)

    Nir-El, Y.

    1977-07-01

    This work determines the independent yield distribution fo the alkali elements' fission products. The results were analyzed by especially developed equations and half-lives were calculated using a computer program which fits a series of exponentials to the activity decay curve by the least squares method. Independent yields were determined by use of calculated correction factors and by normalization against a known independent yield. The three nuclides 147 Ba, 148 Ba, and 149 La were indentified fot the first time in this work and their half-lives were determined Comparison with calculated values, within the framework of beta decay theory, gave in all cases agreement better than an order of magnitude. Extrapolation of the experimental curve and prediction of values which have not yet been measured are now possible. Independent yield distributions of rubidium and cesium include values for 99 Rb, 147 Cs and 148 Cs determined for the first time. The last two isotopes were identified fot the first time in the present work. A model was developed to interpretthe heavy wing phenomenon based on statistical considerations and onbasic properties of prompt neutron emission in fission. The width parameter of the independent yield distribution calculated according to the propsed model is in very good agreement with the width parameter of a Gaussian fitted to the measured distribution. (B.G.)

  2. Effects of curing time and line addition on the microstructure and physical properties of hydrated burnt clay-lime mixes

    International Nuclear Information System (INIS)

    Hajjaji, M.; Mleza, Y.

    2012-01-01

    The change of the microstructure of hydrated burnt illitic-kaolinitic clay-lime blends as a fonction of curing time and line addition were investigated using X-ray diffraction and scanning electron microscope. The relation between physical properties - bending strenght, density and water absorption - and the operating factors were formulated using response surface methodology. It was found that floculation-agglomeration, carbonation and hydrates formation where the main happening transformations. The pozzolanic reactions essentially involved metakaolin, derived from heated kaolinite. Based on the RSM results, both factors had positive effects on the strength and their interactions were synergistic. However, they manifested opposite effects and significant antaginistic interactions on density and water absorption

  3. Penetration of antimicrobials to pulmonary epithelial lining fluid and muscle and impact of drug physicochemical properties determined by microdialysis

    DEFF Research Database (Denmark)

    Rottbøll, Lisa Amanda Holm; Friis, Christian

    2016-01-01

    INTRODUCTION: The objectives of this study were to characterize antimicrobial drug penetration into the pulmonary epithelial lining fluid (PELF) and extracellular fluid (ECF) of muscle in relation to physicochemical properties of the drugs (molecular mass, Log D, polar surface area and charge......), using intrabronchial microdialysis. The series of drugs tested include gentamicin, sulfadiazine, cefquinome, minocycline and colistin. METHODS: Drug concentrations were measured during 2h of steady state plasma drug concentrations at therapeutic levels in anesthetized pigs. Microdialysis probes were.......7) and colistin (0.26, 0.12). The penetration of drugs into PELF (r(2)=0.55-0.77, p=0.0004-0.0089) and ECF of muscle (r(2)=0.39-0.53, p=0.0108-0.0397) was positively correlated to Log D, whereas molecular mass, polar surface area and charge were negatively correlated to drug penetration. Sulfadiazine, gentamicin...

  4. Subcloning the MAC-T bovine mammary epithelial cell line: morphology, growth properties, and cytogenetic analysis of clonal cells.

    Science.gov (United States)

    Zavizion, B; Gorewit, R C; Politis, I

    1995-03-01

    The objectives of the present study were 1) to determine the heterogeneity of the MAC-T cell line; 2) to examine whether homogeneous clones could be derived from MAC-T cells; and 3) to examine cell morphology, cytoskeletal characteristics, size, colony-forming ability, growth characteristics, beta-casein production, response to oxytocin, and cytogenetic properties of the clones. Three clonal cells, designated CU-1, CU-2, and CU-3, were derived from MAC-T cells. CU-1 and CU-2 cells were morphologically homogeneous. CU-3 cells were heterogeneous and contained two distinct subtypes. All clones contained cytokeratin 14 and 18. CU-2 and CU-3 cells were 30 and 18% larger, respectively, than CU-1 cells. CU-1 cells did not grow in serum-free medium. Doubling times for MAC-T, CU-2, and CU-3 were 46, 48, and 78 h, respectively, in serum-free medium. MAC-T cells and clones constitutively expressed beta-casein in culture ranging from .1 to .3 micrograms/ml per 24 h. Cytogenetic analyses revealed Robertsonian translocations and isochromosomes in the clonal lines. We conclude that parental MAC-T cells are heterogeneous in morphology, growth, and cytogenetic characteristics.

  5. Hybrid Ag-based inks for nanocomposite inkjet printed lines: RF properties

    International Nuclear Information System (INIS)

    Chiolerio, Alessandro; Camarchia, Vittorio; Quaglia, Roberto; Pirola, Marco; Pandolfi, Paolo; Pirri, Candido Fabrizio

    2014-01-01

    Highlights: • Polymer–silver nanocomposite conductive ink for RF fast prototyping. • Reduction of the sintering temperature. • Improved printing resolution. • State-of-the-art electrical conductivity. • Good RF performances. - Abstract: The development of highly conductive Ag nanoparticle (NP)-based inkjet printed (IP) connections is a fundamental process for the success of next-generation digitally printed electronics. This is true both at low frequency and at RF, considering the increasing integration of heterogeneous technologies and the use of flexible substrates. Ink-based technologies provide and form at liquid state the functional material that is then delivered to solid via a sintering process to achieve NP coalescence and electrical percolation. Sintering must be performed at very low temperatures (depending on the substrate choice) to be compatible with previous process steps, to preserve the geometry and fulfill the requirements in term of electrical conductivity, as well as to reduce production costs. While IP, as additive technology, is now well settled for DC or low frequency applications, few results on electrical characterization at RF or microwave frequencies are present due to low conductivity, poor geometry definition and low reproducibility. Hence, a good setup of ink formulation and technological realization is fundamental to enable system performance assessment in the high frequency regime. In this paper we propose a breakthrough: we present a nanocomposite ink, whose thermal and DC electrical properties are extremely interesting and competitive with pure-metallic ink systems. Introducing a copolymer in the formulation, we obtained a reduction of the overall sintering temperature, if compared to the pristine NP suspension, along with improved printing resolution together with very good electrical conductivity. The RF characterization has been performed in the range 1–6 GHz on geometries printed on sintered alumina and on a power

  6. Evaluation of genetic effect on physiochemical properties changes of Wx near isogenic lines of Y58S in rice

    Directory of Open Access Journals (Sweden)

    Wentao Sheng

    2015-12-01

    Full Text Available The Wx gene primarily influences the physiochemical properties changes of rice (Oryza sativa L. To improve the grain qualities of the cv. Y58S with low amylose content (AC value, the genetic effect of Wx gene was explored on quality traits. With the BC3F2 genetic population of Y58S line associated with different AC value as the materials, this study reported the genetic effect of three different Wx alleles (Wxª, Wx in, Wx b under near-isogenic background. It was shown that Wx had major effects on the quality traits, and the genetic effect value was in the order Wxª > Wx in > Wx b. In addition, during the course of physiochemical properties changes of higher AC rice cultivars determined by Wxª or Wx in allele, accompanied by the increasing of AC, gel consistency and head milled rice recovery would be decreased in combination with the rising of chalky traits, all of which resulted in substantial fluctuations on quality traits (p < 0.01. However, the genetic law was not evident for Wx b allele. Therefore, except for the major gene Wx, the minor genes in the regulative network of starch-synthesis might be utilized for quality improvement.

  7. Crowdsourcing Broad Absorption Line Properties and Other Features of Quasar Outflow Using Zooniverse Citizen Science Project Platform

    Science.gov (United States)

    Crowe, Cassie; Lundgren, Britt; Grier, Catherine

    2018-01-01

    The Sloan Digital Sky Survey (SDSS) regularly publishes vast catalogs of quasars and other astronomical objects. Previously, the SDSS collaboration has used visual inspection to check quasar redshift validity and flag instances of broad absorption lines (BALs). This information helps researchers to easily single out the quasars with BAL properties and study their outflows and other intervening gas clouds. Due to the ever-growing number of new SDSS quasar observations, visual inspections are no longer possible using previous methods. Currently, BAL information is being determined entirely computationally, and the accuracy of that information is not precisely known. This project uses the Zooniverse citizen science platform to visually inspect quasar spectra for BAL properties, to check the accuracy of the current autonomous methods, and to flag multi-phase outflows and find candidates for in-falling gas into the quasar central engine. The layout and format of a Zooniverse project provides an easier way to inspect and record data on each spectrum and share the workload via crowdsourcing. Work done by the SDSS collaboration members is serving as a beta test for a public project upon the official release of the DR14 quasar catalog by SDSS.

  8. Photophysical Properties of Pheophorbide-a Derivatives and Their Photodynamic Therapeutic Effects on a Tumor Cell Line In Vitro

    Directory of Open Access Journals (Sweden)

    Kang-Kyun Wang

    2014-01-01

    Full Text Available Pheophorbide-a derivatives have been reported to be potential photosensitizers for photodynamic therapy (PDT. In this study, photophysics of pheophorbide-a derivatives (PaDs were investigated along with their photodynamic tumoricidal effect in vitro. PaDs were modified by changing the coil length and/or making the hydroxyl group (–OH substitutions. Their photophysical properties were studied by steady-state and time-resolved spectroscopic methods. The photodynamic tumoricidal effect was evaluated in the mouse breast cancer cell line (EMT6. Lifetime and quantum yield of fluorescence and quantum yields of triplet state and singlet oxygen were studied to determine the dynamic energy flow. The coil length of the substituted alkyl group did not significantly affect the spectroscopic properties. However, the substitution with the hydroxyl group increased the quantum yields of the triplet state and the singlet oxygen due to the enhanced intersystem crossing. In order to check the application possibility as a photodynamic therapy agent, the PaDs with hydroxyl group were studied for the cellular affinity and the photodynamic tumoricidal effect of EMT6. The results showed that the cellular affinity and the photodynamic tumoricidal effect of PaDs with the hydroxyl group depended on the coil-length of the substituted alkyl group.

  9. Red pericarp introgression lines derived from interspecific crosses of rice: physicochemical characteristics, antioxidative properties and phenolic content.

    Science.gov (United States)

    Sharma, Neerja; Kaur, Rimaljeet; Mangat, Gurjit S; Singh, Kuldeep

    2014-11-01

    Antioxidative properties and physicochemical characteristics of introgression lines (ILs) and their recurrent parents were analyzed. In addition, catalase (CAT) and superoxide dismutase (SOD) activities and free radical-scavenging capacity were evaluated, since these are important antioxidative properties for developing nutraceutical and functional foods. Comparative analysis of the brown and milled rice fractions of ILs with their respective recurrent parents revealed 2.26- and 1.22-fold increase in total phenolics, 1.95- and 2.09-fold increase in flavonoids, 8.38- and 6.80-fold increase in proanthocyanidins and 1.55- and 1.20-fold increase in tannins in brown and milled rice fractions respectively. Higher CAT (1.36- and 1.89-fold) and SOD (1.71- and 2.02-fold) activities and Trolox equivalent antioxidant capacity (TEAC, 7.13- and 1.98-fold) were observed in brown and milled rice fractions respectively of ILs compared with their respective recurrent parents. A high and positive correlation was obtained between TEAC and total phenols (0.73, P ≤ 0.01), flavonoids (0.66, P ≤ 0.05) and proanthocyanidins (0.69, P ≤ 0.05). The yield parameters and physicochemical characteristics of the grains, in general, were comparable in the ILs and their respective recurrent parents. The ILs of rice reported in the present study exhibited significant positive differences in the content of phenolic constituents and antioxidant properties with good grain quality characteristics over their recurrent parents, indicating their potential as a natural source of phytochemicals for nutraceutical and functional food development. © 2014 Society of Chemical Industry.

  10. Investigating the effects of elevation changes on vegetation structure and soil properties for the pasturelands above forest line

    Directory of Open Access Journals (Sweden)

    Mehmet Özalp

    2016-10-01

    Full Text Available In this research, changes on botanical composition, fresh and dry forage yields, grazing capacity and some soil properties depending on short altitudinal increments along the natural pasturelands found above forest line near Aydın Village in Ardanuç, Artvin were investigated. For this purpose, total of 36 sampling plots made of 1 m2 size cages with of with the help of wire fences were established at 1900, 2000 and 2200 m altitudes. Vegetation samples taken from these cages were first identified and classified into botanical composition and then their fresh and dry forage yield were estimated along with their grazing capacity. In addition, total of 72 undisturbed and disturbed soil samples taken from 0-20 cm depth were analyzed for permeability, bulk density, content of fine particles and soil skeleton, root amount, texture, particle density, porosity, organic matter (OM and soil pH. According to the estimated results, the mean fresh forage yield was determined as 647.22 kg/da, the mean dry forage yield was estimated to be 196.67 kg/da. It was determined that the botanical composition was made up of %46.16 poaceae (gramineae, %14.36 leguminosae (fabaceae and %39.45 other families and showed some significant differences among the elevation gradients. In addition, some properties of soils including OM, bulk density, the contents of fine particles, soil skeleton and porosity displayed significant differences between the altitudes in the pasturelands. Finally, the results of the correlation analyses revealed that some of the soil properties played significantly important roles on shaping the botanical composition of the pasturelands.

  11. Handbook on loss reserving

    CERN Document Server

    Schmidt, Klaus; Schnaus, Anja

    2016-01-01

    This handbook presents the basic aspects of actuarial loss reserving. Besides the traditional methods, it also includes a description of more recent ones and a discussion of certain problems occurring in actuarial practice, like inflation, scarce data, large claims, slow loss development, the use of market statistics, the need for simulation techniques and the task of calculating best estimates and ranges of future losses. In property and casualty insurance the provisions for payment obligations from losses that have occurred but have not yet been settled usually constitute the largest item on the liabilities side of an insurer's balance sheet. For this reason, the determination and evaluation of these loss reserves is of considerable economic importance for every property and casualty insurer. Actuarial students, academics as well as practicing actuaries will benefit from this overview of the most important actuarial methods of loss reserving by developing an understanding of the underlying stochastic models...

  12. Extreme emission-line galaxies out to z ~ 1 in zCOSMOS. I. Sample and characterization of global properties

    Science.gov (United States)

    Amorín, R.; Pérez-Montero, E.; Contini, T.; Vílchez, J. M.; Bolzonella, M.; Tasca, L. A. M.; Lamareille, F.; Zamorani, G.; Maier, C.; Carollo, C. M.; Kneib, J.-P.; Le Fèvre, O.; Lilly, S.; Mainieri, V.; Renzini, A.; Scodeggio, M.; Bardelli, S.; Bongiorno, A.; Caputi, K.; Cucciati, O.; de la Torre, S.; de Ravel, L.; Franzetti, P.; Garilli, B.; Iovino, A.; Kampczyk, P.; Knobel, C.; Kovač, K.; Le Borgne, J.-F.; Le Brun, V.; Mignoli, M.; Pellò, R.; Peng, Y.; Presotto, V.; Ricciardelli, E.; Silverman, J. D.; Tanaka, M.; Tresse, L.; Vergani, D.; Zucca, E.

    2015-06-01

    Context. The study of large and representative samples of low-metallicity star-forming galaxies at different cosmic epochs is of great interest to the detailed understanding of the assembly history and evolution of low-mass galaxies. Aims: We present a thorough characterization of a large sample of 183 extreme emission-line galaxies (EELGs) at redshift 0.11 ≤ z ≤ 0.93 selected from the 20k zCOSMOS bright survey because of their unusually large emission line equivalent widths. Methods: We use multiwavelength COSMOS photometry, HST-ACS I-band imaging, and optical zCOSMOS spectroscopy to derive the main global properties of star-forming EELGs, such as sizes, stellar masses, star formation rates (SFR), and reliable oxygen abundances using both "direct" and "strong-line" methods. Results: The EELGs are extremely compact (r50 ~ 1.3 kpc), low-mass (M∗ ~ 107-1010 M⊙) galaxies forming stars at unusually high specific star formation rates (sSFR ≡ SFR/M⋆ up to 10-7 yr-1) compared to main sequence star-forming galaxies of the same stellar mass and redshift. At rest-frame UV wavelengths, the EELGs are luminous and show high surface brightness and include strong Lyα emitters, as revealed by GALEX spectroscopy. We show that zCOSMOS EELGs are high-ionization, low-metallicity systems, with median 12+log (O/H) = 8.16 ± 0.21 (0.2 Z⊙) including a handful of extremely metal-deficient (period of their evolution, where they are efficiently building up a significant fraction of their present-day stellar mass in an ongoing, galaxy-wide starburst. Therefore, the EELGs constitute an ideal benchmark for comparison studies between low- and high-redshift low-mass star-forming galaxies. Full Tables 1 and 2 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/578/A105

  13. The introgression of RNAi silencing of γ-gliadins into commercial lines of bread wheat changes the mixing and technological properties of the dough.

    Directory of Open Access Journals (Sweden)

    Javier Gil-Humanes

    Full Text Available In the present work the effects on dough quality by the down-regulation of γ-gliadins in different genetic backgrounds of bread wheat were investigated. RNAi-mediated silencing of γ-gliadins was introgressed by conventional crossing into three commercial bread wheat lines (namely 'Gazul', 'Podenco' and 'Arpain', and along with the transgenic line A1152 (cv. Bobwhite compared with their respective wild types. The protein fractions were quantified by RP-HPLC, whereas the technological and mixing properties were assessed by SDSS test and by the Mixograph instrument. Principal component analysis (PCA was carried out for both the wild types and the transgenic lines, showing differences in the factors affecting the technological and mixing properties of the dough as a consequence of the reduction of the γ-gliadins. In transgenic lines, the α- and ω-gliadins, and total gliadins negatively affected the dough strength and tolerance to over-mixing, whereas the L/H ratio showed the opposite effect, positively influencing the dough quality. The increase of the SDSS volume in the transgenic lines of 'Gazul', 'Podenco' and 'Arpain' indicates increased gluten strength and quality respect to the wild types. SDSS volume was found to be positively influenced by the amount of glutenins, which were also increased in the transgenic lines. In addition, a positive effect was observed in the MT, PR1 and RBD in some of the transgenic lines of 'Podenco' and 'Arpain'. In conclusion, the down-regulation of γ-gliadins resulted in stronger doughs and a better tolerance to over-mixing in some transgenic lines. Although the reduction of γ-gliadins seems not to have a direct effect on the mixing and bread-making properties, the compensatory effect on the synthesis of the other prolamins may result in stronger doughs with improved over-mixing resistance.

  14. Quality properties and expression profiling of protein disulfide isomerase genes during grain development of three spring wheat near isogenic lines

    Directory of Open Access Journals (Sweden)

    Dong Liwei

    2016-01-01

    Full Text Available Three wheat glutenin near isogenic lines (NILs CB037A, CB037B and CB037C were used to investigate their quality properties and the transcriptional expression profiles of PDI gene family during grain development. Our purpose is to understand the relationships between the dynamic expression of different PDI genes and glutenin allelic compositions related to gluten quality. The results showed that glutenin allelic variations had no significant effects on main agronomic traits and yield performance, but resulted in clear gluten quality changes. CB037B with 5+10 subunits had higher glutenin macropolymer (GMP content and better breadmaking quality than CB037A with 2+12 while the lack of Glu-B3h encoding one abundant B-subunit in CB037C significantly reduced GMP content, dough strength and breadmaking quality. The dynamic expression patterns of eight protein disulfide isomerase (PDI genes during grain development detected by quantitative real-time polymerase chain reaction (qRT-PCR showed the close correlations between higher expression levels of PDI3-1, PDI5-1 and PDI8-1 and the presence of 5+10 subunits. Meanwhile, Glu-B3h silence resulted in significant decrease of expression levels of five PDI genes (PDI3-1, PDI5-1, PDI6-1, PDI7-2 and PDI8-1, suggesting the vital roles of certain PDI genes in glutenin and GMP synthesis and gluten quality formation.

  15. The importance of nuclear quantum effects in spectral line broadening of optical spectra and electrostatic properties in aromatic chromophores

    Science.gov (United States)

    Law, Y. K.; Hassanali, A. A.

    2018-03-01

    In this work, we examine the importance of nuclear quantum effects on capturing the line broadening and vibronic structure of optical spectra. We determine the absorption spectra of three aromatic molecules indole, pyridine, and benzene using time dependent density functional theory with several molecular dynamics sampling protocols: force-field based empirical potentials, ab initio simulations, and finally path-integrals for the inclusion of nuclear quantum effects. We show that the absorption spectrum for all these chromophores are similarly broadened in the presence of nuclear quantum effects regardless of the presence of hydrogen bond donor or acceptor groups. We also show that simulations incorporating nuclear quantum effects are able to reproduce the heterogeneous broadening of the absorption spectra even with empirical force fields. The spectral broadening associated with nuclear quantum effects can be accounted for by the broadened distribution of chromophore size as revealed by a particle in the box model. We also highlight the role that nuclear quantum effects have on the underlying electronic structure of aromatic molecules as probed by various electrostatic properties.

  16. Properties of Surfactin C-15 Nanopeptide and Its Cytotoxic Effect on Human Cervix Cancer (HeLa Cell Line

    Directory of Open Access Journals (Sweden)

    Zahra Nozhat

    2012-01-01

    Full Text Available Surfactin is one of the most powerful biosurfactants that has been known so far. It is an acidic cyclic nonribosomal lipoheptapeptide that is produced by Bacillus subtilis. In this presentation we investigated different properties of surfactin C-15. The nanomicelle forming ability of surfactin C-15 in different aqueous environments with various ionic strengths was studied by scanning electron microscope. Surfactin second structure was investigated by Far-UV CD spectrum. Its hemolytic activity and cytotoxicity were measured by hemolysis and MTT assays, respectively. Surfactin formed spherical nanomicelles in distilled water and amorphous nanomicelles in PBS buffer . The hemolysis assay results indicated that HC50 of surfactin was 47 μM. Surfactin C-15 arrested growth of human cervix cancer HeLa cell line in a time- and dosage-dependent method, so that its IC50 at 16, 24, and 48h were 86.9, 73.1, and 50.2 μM, respectively.

  17. Effects of the addition of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on mechanical properties of luting and lining glass ionomer cement

    Science.gov (United States)

    Heravi, Farzin; Bagheri, Hossein; Rangrazi, Abdolrasoul; Mojtaba Zebarjad, Seyed

    2016-07-01

    Recently, the addition of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) into glass ionomer cements (GICs) has attracted interest due to its remineralization of teeth and its antibacterial effects. However, it should be investigated to ensure that the incorporation of CPP-ACP does not have significant adverse effects on its mechanical properties. The purpose of this study was to evaluate the effects of the addition of CPP-ACP on the mechanical properties of luting and lining GIC. The first step was to synthesize the CPP-ACP. Then the CPP-ACP at concentrations of 1%, 1.56% and 2% of CPP-ACP was added into a luting and lining GIC. GIC without CPP-ACP was used as a control group. The results revealed that the incorporation of CPP-ACP up to 1.56%(w/w) increased the flexural strength (29%), diametral tensile strength (36%) and microhardness (18%), followed by a reduction in these mechanical properties at 2%(w/w) CPP-ACP. The wear rate was significantly decreased (23%) in 1.56%(w/w) concentration of CPP-ACP and it was increased in 2%(w/w). Accordingly, the addition of 1.56%(w/w) CPP-ACP into luting and lining GIC had no adverse effect on the mechanical properties of luting and lining GIC and could be used in clinical practice.

  18. Amiloride causes changes in the mechanical properties of hair cell bundles in the fish lateral line similar to those induced by dihydrostreptomycin

    NARCIS (Netherlands)

    Wiersinga-Post, JEC; van Netten, SM

    1998-01-01

    Amiloride is a known blocker of the mechano-electrical transduction current in sensory hair cells. Measurements of cupular motion in the lateral line organ of fish now show that amiloride concurrently changes the micromechanical properties of the hair cell bundles. The effects of amiloride on the

  19. Derivation of transplantable 7,12-dimethylbenz[a]anthracene-induced chicken fibrosarcoma lines: differences in metastasizing properties and organ specificity

    International Nuclear Information System (INIS)

    Galton, J.E.; Xue, B.; Hochwald, G.M.; Thorbecke, G.J.

    1982-01-01

    Transplantable 7,12-dimethylbenz[a]anthracene-induced SC chicken fibrosarcoma (CHCT-NYU) lines were studied for their ability to grow in internal organs after iv injection (artificial metastases) into 1- to 3-week-old chickens. Some tumor lines were recently derived, whereas others were studied after many serial subcutaneous transplantations. Artificial metastases were seen in the stomach, pancreas, lungs, heart, and muscle, and occasionally in the kidneys and liver. Agammaglobulinemic recipients showed more extensive organ involvement than normal recipients of the same age. Whole-body ν-irradiation enhanced the incidence of artificial metastases, particularly in lungs. Antibody from the serum of a primary tumor-bearing host reduced the growth of the corresponding tumor in many organs. The metastatic pattern of line CHCT-NYU4 was a relatively stable property. However, intravenous transplantation of tumor cells from line CHCT-NYU4 taken from the liver, lungs, and pancreas of a single recipient established sublines with changes in organ specificity. After a few such serial transplants of liver-derived tumor, a line was derived that grew virtually in the liver alone. A subline with preference for growth in lungs was also obtained, but its ability to grow in the pancreas persisted. A pancreas-derived tumor line also grew in the liver and lungs. Subcutaneous transplants of tissue fragments of the lung-derived tumor line caused the appearance of spontaneous metastases in lungs. The incidence of spontaneous metastases with the lung-derived line was much greater than that with the liver-derived line or with the original CHCT-NYU4 line

  20. Hydrodynamic properties of the gonadotropin receptor from a murine Leydig tumor cell line are altered by desensitization

    International Nuclear Information System (INIS)

    Rebois, R.V.; Bradley, R.M.; Titlow, C.C.

    1987-01-01

    The murine Leydig tumor cell line 1 (MLTC-1) contains gonadotropin receptors (GR) that are coupled to adenylate cyclase through the stimulatory guanine nucleotide binding protein (G/sub s/). The binding of human choriogonadotropin (hGC) causes MLTC-1 cells to accumulate cAMP. With time, the ability of MLTC-1 cells to respond to hCG is attenuated by a process called desensitization. The hydrodynamic properties of GR from control and desensitized MLTC-1 cells were studied. Sucrose density gradient sedimentation in H 2 O and D 2 O and gel filtration chromatography were used to estimate the Stokes radius (a), partial specific volume (v/sub c/), sedimentation coefficient (s/sub 20,w/), and molecular weight (M/sub r/) of the detergent-solubilized hormone-receptor complex (hCG-GR). [ 125 I]hCG was bound to MLTC-1 cells under conditions that allow (37 0 C) or prevent (0 0 C) desensitization, and hCG-GR was solubilized in Triton X-100. In the absence of desensitization, control hCG-GR had a M/sub r/ of 213,000, whereas desensitized hCG-GR had a M/sub r/ of 158,000. Deglycosylated hCG (DG-HCG) is an antagonist that binds to GR with high affinity but fails to stimulate adenylate cyclase or cause desensitization. [ 125 I]DG-hCG was bound to MLTC-1 cells and DG-hCG-GR solubilized in Triton X-100. The hydrodynamic properties of DG-hCG-GR were the same as that for control hCG-GR. There was no evidence for the association of adenylate cyclase or G/sub s/ with GR in Triton X-100 solubilized preparations. When hCG was cross-linked to GR and solubilized with sodium dodecyl sulfate (SDS), the M/sub r/ was found to be 116,000, which was similar to that determined by SDS-polyacrylamide gel electrophoresis and less than that of the Triton X-100 solubilized control hCG-GR

  1. Differences in the transcriptome signatures of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic properties

    Directory of Open Access Journals (Sweden)

    Stanley Samuel L

    2010-01-01

    Full Text Available Abstract Background The availability of two genetically very similar cell lines (A and B derived from the laboratory isolate Entamoeba histolytica HM-1:IMSS, which differ in their virulence properties, provides a powerful tool for identifying pathogenicity factors of the causative agent of human amoebiasis. Cell line A is incapable inducing liver abscesses in gerbils, whereas interaction with cell line B leads to considerable abscess formation. Phenotypic characterization of both cell lines revealed that trophozoites from the pathogenic cell line B have a larger cell size, an increased growth rate in vitro, an increased cysteine peptidase activity and higher resistance to nitric oxide stress. To find proteins that may serve as virulence factors, the proteomes of both cell lines were previously studied, resulting in the identification of a limited number of differentially synthesized proteins. This study aims to identify additional genes, serving as virulence factors, or virulence markers. Results To obtain a comprehensive picture of the differences between the cell lines, we compared their transcriptomes using an oligonucleotide-based microarray and confirmed findings with quantitative real-time PCR. Out of 6242 genes represented on the array, 87 are differentially transcribed (≥two-fold in the two cell lines. Approximately 50% code for hypothetical proteins. Interestingly, only 19 genes show a five-fold or higher differential expression. These include three rab7 GTPases, which were found with a higher abundance in the non-pathogenic cell line A. The aig1-like GTPasesare of special interest because the majority of them show higher levels of transcription in the pathogenic cell line B. Only two molecules were found to be differentially expressed between the two cell lines in both this study and our previous proteomic approach. Conclusions In this study we have identified a defined set of genes that are differentially transcribed between the non

  2. 26 CFR 1.1055-4 - Basis of redeemable ground rent reserved or created in connection with transfers of real property...

    Science.gov (United States)

    2010-04-01

    ... price of $2,000. The taxpayer reported a $2,000 gain on the transfer, treating the amount realized as... created in connection with transfers of real property before April 11, 1963. 1.1055-4 Section 1.1055-4... with transfers of real property before April 11, 1963. (a) In general. In the case of a redeemable...

  3. AISI/DOE Advanced Process Control Program Vol. 4 of 6: ON-LINE, NON-DESTRUCTIVE MECHANICAL PROPERTY MEASUREMENT USING LASER-ULTRASOUND

    Energy Technology Data Exchange (ETDEWEB)

    Andre' Moreau; Martin Lord; Daniel Levesqure; Marc Dubois; Jean Bussiere; Jean-Pierre Monchalin; Christian Padioleau; Guy Lamouche; Teodor Veres; Martin Viens; Harold Hebert; Pierre Basseras; Cheng-Kuei Jen

    2001-03-31

    The goal of this project was to demonstrate the feasibility to measure the mechanical properties, such as yield strength, tensile strength, elongation, strain hardening exponent and plastic strain ratio parameters, of low carbon steel sheets on the production line using laser ultrasound. The ultrasound generated by the developed apparatus travels mostly back and forth in the thickness of the steel sheet. By measuring the time delay between two echoes, and the relative amplitude of these two echoes, one can measure ultrasound velocity and attenuation. These are governed by the microstructure: grain size, crystallographic texture, dislocations, etc. Thus, by recording the time behavior of the ultrasonic signal, one can extract microstructural information. These microstructural information together with the modified Hall-Petch equation allow measurement of the mechanical properties. Through laboratory investigations with a laboratory laser ultrasound system, followed by the installation of a prototype system at LTV Steel Company's No.1 Inspection Line in Cleveland, all target mechanical properties of ultra low carbon (ULC), low carbon (LC) and high strength low alloy (HSLA) steel sample lots were measured meeting or nearly meeting all the target accuracies. Thus, the project realized its goal to demonstrate that the mechanical properties of low carbon steel sheets can be measured on-line using laser ultrasound

  4. INTRINSIC FACTORS AND FIRM FINANCIAL ANALYSIS WITH TRIPPLE BOTTOM LINES AS INTERVENING VARIABLE AGAINST FIRM VALUE Empirical Studies on Property and Real Estate Companies Year 2010-2013

    Directory of Open Access Journals (Sweden)

    Mia Andika Sari

    2016-09-01

    Full Text Available This research conducted to examine the influence of intrinsic factors which being peroxided with Capital Structure, Firm Size, Firm Age and Financial factors that being peroxided with liquidity, profitability also with another activities using triple bottom lines as Intervening Variable against Firm Value of Property Industries. The data that being used in this study were obtained from published financial statements during the period 2010 to 2013, as well as annual reports that can be accessed through the IDX website. Data analysis technique used in this study is a regression with panel data and path analysis. The results of this research showed that intrinsic factors and financial variables have a significant influence on the firm value, as well as intrinsic factors and financial variables have a significant influence on the triple bottom lines. From the results of path analysis demonstrated that the indirect effect using the triple bottom lines as a intervening variable was greater than the direct effect.

  5. MID-INFRARED PROPERTIES OF THE SWIFT BURST ALERT TELESCOPE ACTIVE GALACTIC NUCLEI SAMPLE OF THE LOCAL UNIVERSE. I. EMISSION-LINE DIAGNOSTICS

    International Nuclear Information System (INIS)

    Weaver, K. A.; Melendez, M.; Mushotzky, R. F.; Kraemer, S.; Engle, K.; Malumuth, E.; Tueller, J.; Markwardt, C.; Berghea, C. T.; Dudik, R. P.; Winter, L. M.; Armus, L.

    2010-01-01

    We compare mid-infrared emission-line properties from high-resolution Spitzer spectra of a hard X-ray (14-195 keV) selected sample of nearby (z < 0.05) active galactic nuclei (AGNs) detected by the Burst Alert Telescope (BAT) aboard Swift. The luminosity distribution for the mid-infrared emission lines, [O IV] 25.89 μm, [Ne II] 12.81 μm, [Ne III] 15.56 μm, and [Ne V] 14.32/24.32 μm, and hard X-ray continuum show no differences between Seyfert 1 and Seyfert 2 populations; however, six newly discovered BAT AGNs are under-luminous in [O IV], most likely the result of dust extinction in the host galaxy. The overall tightness of the mid-infrared correlations and BAT fluxes and luminosities suggests that the emission lines primarily arise in gas ionized by the AGNs. We also compare the mid-infrared emission lines in the BAT AGNs with those from published studies of ULIRGs, Palomar-Green quasars, star-forming galaxies, and LINERs. We find that the BAT AGN sample falls into a distinctive region when comparing the [Ne III]/[Ne II] and the [O IV]/[Ne III] ratios. These line ratios are lower in sources that have been previously classified in the mid-infrared/optical as AGNs than those found for the BAT AGNs, suggesting that, in our X-ray selected sample, the AGNs represent the main contribution to the observed line emission. These ratios represent a new emission line diagnostic for distinguishing between AGNs and star-forming galaxies.

  6. Prima facie reasons to question enclosed intellectual property regimes and favor open-source regimes for germplasm [version 1; referees: 2 approved, 1 approved with reservations

    Directory of Open Access Journals (Sweden)

    Madeleine-Thérèse Halpert

    2017-03-01

    Full Text Available In principle, intellectual property protections (IPPs promote and protect important but costly investment in research and development. However, the empirical reality of IPPs has often gone without critical evaluation, and the potential of alternative approaches to lend equal or greater support for useful innovation is rarely considered. In this paper, we review the mounting evidence that the global intellectual property regime (IPR for germplasm has been neither necessary nor sufficient to generate socially beneficial improvements in crop plants and maintain agrobiodiversity. Instead, based on our analysis, the dominant global IPR appears to have contributed to consolidation in the seed industry while failing to genuinely engage with the potential of alternatives to support social goods such as food security, adaptability, and resilience. The dominant IPR also constrains collaborative and cumulative plant breeding processes that are built upon the work of countless farmers past and present. Given the likely limits of current IPR, we propose that social goods in agriculture may be better supported by alternative approaches, warranting a rapid move away from the dominant single-dimensional focus on encouraging innovation through ensuring monopoly profits to IPP holders.

  7. Property description and fact-finding report for NPR-3 Natrona County, Wyoming. Addendum to 22 August 1996 study of alternatives for future operations of the naval petroleum and oil shale reserves NPR-3

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-05-01

    The U.S. Department of Energy has asked Gustavson Associates, Inc. to serve as an Independent Petroleum Consultant under contract DE-AC01-96FE64202. This authorizes a study and recommendations regarding future development of Naval Petroleum Reserve No. 3 (NPR-3) in Natrona County, Wyoming. The report that follows is the Phase I fact-finding and property description for that study. The United States of America owns 100 percent of the mineral rights and surface rights in 9,321-acre NPR-3. This property comprises the Teapot Dome oil field and related production, processing and other facilities. Discovered in 1914, this field has 632 wells producing 1,807 barrels of oil per day. Production revenues are about $9.5 million per year. Remaining recoverable reserves are approximately 1.3 million barrels of oil. Significant plugging and abandonment (P&A) and environmental liabilities are present.

  8. Grain quality characteristics and dough rheological properties in Langdon durum-wild emmer wheat chromosome substitution lines under nitrogen and water deficits.

    Science.gov (United States)

    Salmanowicz, Bolesław P; Langner, Monika; Mrugalska, Beata; Ratajczak, Dominika; Górny, Andrzej G

    2017-05-01

    Wild emmer wheat could serve as a source of novel variation in grain quality and stress resistance for wheat breeding. A set of Triticum durum-T. dicoccoides chromosome substitution lines [LDN(DIC)] and the parental recipient cv. Langdon grown under contrasting water and nitrogen availability in the soil was examined in this study to identify differences in grain quality traits and dough rheological properties. Significant genotypic variation was found among the materials for studied traits. This variation was also considerably affected by soil treatments and G × E interactions. The substitutions LDN(DIC-1A) and LDN(DIC-1B) showed separate differentiation in the composition of glutenin sub-units. The results indicated that primarily chromosome DIC-6B is stable source of an enhanced grain protein content and advantageous dough rheological properties. Similar features seem to be shown by the substitutions with the DIC-1A, DIC-2A and DIC-6A, but not under nitrogen shortage, when generally a considerable decrease was noticed in the range of genotypic variation in grain quality. The substitution lines, particularly those with DIC-6B and DIC-6A and to a lesser extent DIC-1A and DIC-2A, were distinguished by advantageous grain quality traits, mixing properties and dough functionality and appear to be the most promising sources of innovative genes for wheat breeding. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  9. Compositional and electrical properties of line and planar defects in Cu(In,Ga)Se2 thin films for solar cells - a review

    International Nuclear Information System (INIS)

    Abou-Ras, Daniel; Schmidt, Sebastian S.; Schaefer, Norbert; Kavalakkatt, Jaison; Rissom, Thorsten; Unold, Thomas; Mainz, Roland; Weber, Alfons; Kirchartz, Thomas; Simsek Sanli, Ekin; Aken, Peter A. van; Ramasse, Quentin M.; Kleebe, Hans-Joachim; Azulay, Doron; Balberg, Isaac; Millo, Oded; Cojocaru-Miredin, Oana; Barragan-Yani, Daniel; Albe, Karsten; Haarstrich, Jakob; Ronning, Carsten

    2016-01-01

    The present review gives an overview of the various reports on properties of line and planar defects in Cu(In,Ga)(S,Se) 2 thin films for high-efficiency solar cells. We report results from various analysis techniques applied to characterize these defects at different length scales, which allow for drawing a consistent picture on structural and electronic defect properties. A key finding is atomic reconstruction detected at line and planar defects, which may be one mechanism to reduce excess charge densities and to relax deep-defect states from midgap to shallow energy levels. On the other hand, nonradiative Shockley-Read-Hall recombination is still enhanced with respect to defect-free grain interiors, which is correlated with substantial reduction of luminescence intensities. Comparison of the microscopic electrical properties of planar defects in Cu(In,Ga)(S,Se) 2 thin films with two-dimensional device simulations suggest that these defects are one origin of the reduced open-circuit voltage of the photovoltaic devices. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  10. Evaluation of some chemical and technological properties of induced erect chickpea mutant lines developed under drought stressed conditions

    International Nuclear Information System (INIS)

    Moustafa, R.A.K.; Ali, H.G.M.

    2009-01-01

    Seeds of the chickpea variety Flip 99-47 C were treated with gamma rays at doses of 0, 50 and 75 Gy and sown in the winter season of 2004/2005 to raise M1 generation under ordinary (normal) irrigation conditions. Bulked seeds from each treatment were planted in the subsequent growing seasons of 2005/2006 and 2006/2007 to advance M2 and M3 generations, respectively under either ordinary (normal) irrigation or drought stress condition. In the third generation, three erect mutant lines were derived from 75 Gy mutagenic treatment under drought stress compared to semi spreading growth habit of the initiated variety Flip 99-47 C. In the winter season of 2007/2008, M4 bulked seeds from the three erect lines as well as unirradiated seeds of the original variety grown under either ordinary (normal) irrigation (2152.5 m 3 /fad.) or drought (1159.2 m 3 /fad.) conditions were analyzed for the chemical composition and nutritional values. Obtained results indicated that there were slight decreases in protein and fat contents accompanied with marginal increases in both ash and carbohydrates in seed samples of the erect mutant developed under drought stress as compared to unirradiated seeds of the original variety grown under ordinary (normal) irrigation treatment. An opposite trend was noticed between seed samples derived from the erect lines compared to seeds of the parent variety developed under drought condition. Negligible changes in levels of the minerals (iron, magnesium, calcium and phosphorus) were detected between seeds of the erect lines and the original variety that grown under either ordinary (normal) irrigation or drought conditions. Cooking time (min) and hydration coefficient values did not much differ between the three tested seed samples. Marginal differences in essential and non-essential amino acids were detected between seeds of the erect mutants and those of the initial variety grown under ordinary (normal) irrigation or drought stressed conditions

  11. Effects of cavity surface temperature on mechanical properties of specimens with and without a weld line in rapid heat cycle molding

    International Nuclear Information System (INIS)

    Wang, Guilong; Zhao, Guoqun; Wang, Xiaoxin

    2013-01-01

    Highlights: ► Higher cavity surface temperature reduces tensile strength of non-weldline part. ► Higher cavity surface temperature increases weldline tensile strength for PS and PP. ► Higher cavity surface temperature reduces weldline tensile strength for ABS, ABS/PMMA, ABS/PMMA/nano-C a CO 3 and FRPP. ► Tensile strength is reduced more by the weldline than impact strength. ► FRPP has the lowest weld line factor than other plastics without reinforced fibers. - Abstract: Rapid heat cycle molding (RHCM) is a recently developed injection molding technology to enhance surface esthetic of the parts. By rapid heating and cooling of mold cavity surfaces in molding process, it can greatly alleviate or even eliminate the surface defects such as flow mark, weld line, glass fiber rich surface, silver mark, jetting mark, and swirl mark, and also improve gloss finish and dimensional accuracy without prolonging the molding cycle. Besides surface esthetic, mechanical property is also a very import issue for the molded plastic part. The aim of this study is focusing on the effects of the cavity surface temperature just before filling, T cs , in RHCM on the mechanical strength of the specimen with and without weld line. Six kinds of typical plastics including polystyrene (PS), polypropylene (PP), acrylonitrile butadiene styrene (ABS), acrylonitrile butadiene styrene/polymethylmethacrylate (ABS/PMMA), ABS/PMMA/nano-C a CO 3 and glass fiber reinforced polypropylene (FRPP) are used in experiments. The specimens with and without a weld line are produced with the different T cs on the developed electric-heating RHCM system. Tensile tests and notched Izod impact tests are conducted to characterize the mechanical strength of the specimens molded with different cavity surface temperatures. Simulations, differential scanning calorimetry (DSC), scanning electron microscope (SEM) and optical microscope are implemented to explain the impact mechanism of T cs on mechanical properties

  12. Establishment of highly tumorigenic human colorectal cancer cell line (CR4 with properties of putative cancer stem cells.

    Directory of Open Access Journals (Sweden)

    Rebecca A Rowehl

    Full Text Available BACKGROUND: Colorectal cancer (CRC has the third highest mortality rates among the US population. According to the most recent concept of carcinogenesis, human tumors are organized hierarchically, and the top of it is occupied by malignant stem cells (cancer stem cells, CSCs, or cancer-initiating cells, CICs, which possess unlimited self-renewal and tumor-initiating capacities and high resistance to conventional therapies. To reflect the complexity and diversity of human tumors and to provide clinically and physiologically relevant cancer models, large banks of characterized patient-derived low-passage cell lines, and especially CIC-enriched cell lines, are urgently needed. PRINCIPAL FINDINGS: Here we report the establishment of a novel CIC-enriched, highly tumorigenic and clonogenic colon cancer cell line, CR4, derived from liver metastasis. This stable cell line was established by combining 3D culturing and 2D culturing in stem cell media, subcloning of cells with particular morphology, co-culture with carcinoma associated fibroblasts (CAFs and serial transplantation to NOD/SCID mice. Using RNA-Seq complete transcriptome profiling of the tumorigenic fraction of the CR4 cells in comparison to the bulk tumor cells, we have identified about 360 differentially expressed transcripts, many of which represent stemness, pluripotency and resistance to treatment. Majority of the established CR4 cells express common markers of stemness, including CD133, CD44, CD166, EpCAM, CD24 and Lgr5. Using immunocytochemical, FACS and western blot analyses, we have shown that a significant ratio of the CR4 cells express key markers of pluripotency markers, including Sox-2, Oct3/4 and c-Myc. Constitutive overactivation of ABC transporters and NF-kB and absence of tumor suppressors p53 and p21 may partially explain exceptional drug resistance of the CR4 cells. CONCLUSIONS: The highly tumorigenic and clonogenic CIC-enriched CR4 cell line may provide an important new

  13. A novel rat fibrosarcoma cell line from transformed bone marrow-derived mesenchymal stem cells with maintained in vitro and in vivo stemness properties

    International Nuclear Information System (INIS)

    Wang, Meng-Yu; Nestvold, Janne; Rekdal, Øystein; Kvalheim, Gunnar; Fodstad, Øystein

    2017-01-01

    Increasing evidence suggests a possible relationship between mesenchymal stem cells (MSCs) and sarcoma. MSCs are hypothesized to be the cells initiating sarcomagenesis, and cancer stem cells (CSCs) sharing features of MSCs have been identified in sarcomas. Here, we report on the characteristics of a bone marrow-derived rat mesenchymal stem cell line that spontaneously transformed in long-term culture. The rat transformed mesenchymal stem cells (rTMSCs) produced soft-tissue fibrosarcomas in immunocompromised mice and immunocompetent rats. In vitro, the rTMSCs displayed increased proliferation capacity compared to the untransformed cell line. The transformed MSCs maintained the mesenchymal phenotype by expression of the stem cell marker CD 90 and the lack of hematopoietic and endothelial markers. Cytogenetic analysis detected trisomy 6 in the rTMSCs. Side population (SP) isolation and tumorsphere cultivation of the transformed cells confirmed the presence of CSCs among the rTMSCs. Importantly, the rTMSCs retained their differentiation capacity towards osteogenic and adipogenic lineages. This transformed MSC-based cell line may be valuable in examining the balance in a mixed cell population between cancer stem cell properties and the ability to differentiate to specific non-transformed cell populations. Moreover, it may also be a useful tool to evaluate the efficacy of novel targeted immunotherapies in vivo. - Highlights: • Spontaneously transformed rat MSCs (rTMSCs) share characteristics with normal MSCs. • rTMSCs possess a side population, enriched with tumorigenic cells. • rTMSCs model fibrosarcoma in vivo.

  14. The dependence of C IV broad absorption line properties on accompanying Si IV and Al III absorption: relating quasar-wind ionization levels, kinematics, and column densities

    Energy Technology Data Exchange (ETDEWEB)

    Filiz Ak, N.; Brandt, W. N.; Schneider, D. P.; Trump, J. R. [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Hall, P. B. [Department of Physics and Astronomy, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3 (Canada); Anderson, S. F. [Astronomy Department, University of Washington, Seattle, WA 98195 (United States); Hamann, F. [Department of Astronomy, University of Florida, Gainesville, FL 32611-2055 (United States); Myers, Adam D. [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82071 (United States); Pâris, I. [Departamento de Astronomía, Universidad de Chile, Casilla 36-D, Santiago (Chile); Petitjean, P. [Institut d' Astrophysique de Paris, Universite Paris 6, F-75014 Paris (France); Ross, Nicholas P. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Shen, Yue [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); York, Don, E-mail: nfilizak@astro.psu.edu [Department of Astronomy and Astrophysics, The University of Chicago, Chicago, IL 60637 (United States)

    2014-08-20

    We consider how the profile and multi-year variability properties of a large sample of C IV Broad Absorption Line (BAL) troughs change when BALs from Si IV and/or Al III are present at corresponding velocities, indicating that the line of sight intercepts at least some lower ionization gas. We derive a number of observational results for C IV BALs separated according to the presence or absence of accompanying lower ionization transitions, including measurements of composite profile shapes, equivalent width (EW), characteristic velocities, composite variation profiles, and EW variability. We also measure the correlations between EW and fractional-EW variability for C IV, Si IV, and Al III. Our measurements reveal the basic correlated changes between ionization level, kinematics, and column density expected in accretion-disk wind models; e.g., lines of sight including lower ionization material generally show deeper and broader C IV troughs that have smaller minimum velocities and that are less variable. Many C IV BALs with no accompanying Si IV or Al III BALs may have only mild or no saturation.

  15. A novel rat fibrosarcoma cell line from transformed bone marrow-derived mesenchymal stem cells with maintained in vitro and in vivo stemness properties

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Meng-Yu [Department of Cell Therapy, Institute for Cancer Research, Oslo University Hospital, Oslo (Norway); Nestvold, Janne, E-mail: j.m.nestvold@medisin.uio.no [Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo (Norway); Rekdal, Øystein [Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø (Norway); Kvalheim, Gunnar [Department of Cell Therapy, Institute for Cancer Research, Oslo University Hospital, Oslo (Norway); Fodstad, Øystein [Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo (Norway)

    2017-03-15

    Increasing evidence suggests a possible relationship between mesenchymal stem cells (MSCs) and sarcoma. MSCs are hypothesized to be the cells initiating sarcomagenesis, and cancer stem cells (CSCs) sharing features of MSCs have been identified in sarcomas. Here, we report on the characteristics of a bone marrow-derived rat mesenchymal stem cell line that spontaneously transformed in long-term culture. The rat transformed mesenchymal stem cells (rTMSCs) produced soft-tissue fibrosarcomas in immunocompromised mice and immunocompetent rats. In vitro, the rTMSCs displayed increased proliferation capacity compared to the untransformed cell line. The transformed MSCs maintained the mesenchymal phenotype by expression of the stem cell marker CD 90 and the lack of hematopoietic and endothelial markers. Cytogenetic analysis detected trisomy 6 in the rTMSCs. Side population (SP) isolation and tumorsphere cultivation of the transformed cells confirmed the presence of CSCs among the rTMSCs. Importantly, the rTMSCs retained their differentiation capacity towards osteogenic and adipogenic lineages. This transformed MSC-based cell line may be valuable in examining the balance in a mixed cell population between cancer stem cell properties and the ability to differentiate to specific non-transformed cell populations. Moreover, it may also be a useful tool to evaluate the efficacy of novel targeted immunotherapies in vivo. - Highlights: • Spontaneously transformed rat MSCs (rTMSCs) share characteristics with normal MSCs. • rTMSCs possess a side population, enriched with tumorigenic cells. • rTMSCs model fibrosarcoma in vivo.

  16. Models of Emission-Line Profiles and Spectral Energy Distributions to Characterize the Multi-Frequency Properties of Active Galactic Nuclei

    Directory of Open Access Journals (Sweden)

    Giovanni La Mura

    2017-11-01

    Full Text Available The spectra of active galactic nuclei (AGNs are often characterized by a wealth of emission lines with different profiles and intensity ratios that lead to a complicated classification. Their electromagnetic radiation spans more than 10 orders of magnitude in frequency. In spite of the differences between various classes, the origin of their activity is attributed to a combination of emitting components, surrounding an accreting supermassive black hole (SMBH, in the unified model. Currently, the execution of sky surveys, with instruments operating at various frequencies, provides the possibility to detect and to investigate the properties of AGNs on very large statistical samples. As a result of the spectroscopic surveys that allow the investigation of many objects, we have the opportunity to place new constraints on the nature and evolution of AGNs. In this contribution, we present the results obtained by working on multi-frequency data, and we discuss their relations with the available optical spectra. We compare our findings with the AGN unified model predictions, and we present a revised technique to select AGNs of different types from other line-emitting objects. We discuss the multi-frequency properties in terms of the innermost structures of the sources.

  17. Single-channel properties of a stretch-sensitive chloride channel in the human mast cell line HMC-1.

    Science.gov (United States)

    Wang, Lina; Ding, Guanghong; Gu, Quanbao; Schwarz, Wolfgang

    2010-04-01

    A stretch-activated (SA) Cl(-) channel in the plasma membrane of the human mast cell line HMC-1 was identified in outside-out patch-clamp experiments. SA currents, induced by pressure applied to the pipette, exhibited voltage dependence with strong outward rectification (55.1 pS at +100 mV and an about tenfold lower conductance at -100 mV). The probability of the SA channel being open (P (o)) also showed steep outward rectification and pressure dependence. The open-time distribution was fitted with three components with time constants of tau(1o) = 755.1 ms, tau(2o) = 166.4 ms, and tau(3o) = 16.5 ms at +60 mV. The closed-time distribution also required three components with time constants of tau(1c) = 661.6 ms, tau(2c) = 253.2 ms, and tau(3c) = 5.6 ms at +60 mV. Lowering extracellular Cl(-) concentration reduced the conductance, shifted the reversal potential toward chloride reversal potential, and decreased the P (o) at positive potentials. The SA Cl(-) currents were reversibly blocked by the chloride channel blocker 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) but not by (Z)-1-(p-dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene (tamoxifen). Furthermore, in HMC-1 cells swelling due to osmotic stress, DIDS could inhibit the increase in intracellular [Ca(2+)] and degranulation. We conclude that in the HMC-1 cell line, the SA outward currents are mediated by Cl(-) influx. The SA Cl(-) channel might contribute to mast cell degranulation caused by mechanical stimuli or accelerate membrane fusion during the degranulation process.

  18. Fluids confined in wedges and by edges: virial series for the line-thermodynamic properties of hard spheres.

    Science.gov (United States)

    Urrutia, Ignacio

    2014-12-28

    This work is devoted to analyze the relation between the thermodynamic properties of a confined fluid and the shape of its confining vessel. Recently, new insights in this topic were found through the study of cluster integrals for inhomogeneous fluids that revealed the dependence on the vessel shape of the low density behavior of the system. Here, the statistical mechanics and thermodynamics of fluids confined in wedges or by edges is revisited, focusing on their cluster integrals. In particular, the well known hard sphere fluid, which was not studied in this framework so far, is analyzed under confinement and its thermodynamic properties are analytically studied up to order two in the density. Furthermore, the analysis is extended to the confinement produced by a corrugated wall. These results rely on the obtained analytic expression for the second cluster integral of the confined hard sphere system as a function of the opening dihedral angle 0 < β < 2π. It enables a unified approach to both wedges and edges.

  19. Cloud-Resolving Modeling Intercomparison Study of a Squall Line Case from MC3E - Properties of Convective Core

    Science.gov (United States)

    Fan, J.; Han, B.; Varble, A.; Morrison, H.; North, K.; Kollias, P.; Chen, B.; Dong, X.; Giangrande, S. E.; Khain, A.; Lin, Y.; Mansell, E.; Milbrandt, J.; Stenz, R.; Thompson, G.; Wang, Y.

    2016-12-01

    The large spread in CRM model simulations of deep convection and aerosol effects on deep convective clouds (DCCs) makes it difficult to (1) further our understanding of deep convection and (2) define "benchmarks" and then limit their use in parameterization developments. A constrained model intercomparsion study on a mid-latitude mesoscale squall line is performed using the Weather Research & Forecasting (WRF) model at 1-km horizontal grid spacing with eight cloud microphysics schemes to understand specific processes that lead to the large spreads of simulated convection and precipitation. Various observational data are employed to evaluate the baseline simulations. All simulations tend to produce a wider convective area but a much narrower stratiform area. The magnitudes of virtual potential temperature drop, pressure rise, and wind speed peak associated with the passage of the gust front are significantly smaller compared with the observations, suggesting simulated cool pools are weaker. Simulations generally overestimate the vertical velocity and radar reflectivity in convective cores compared with the retrievals. The modeled updraft velocity and precipitation have a significant spread across eight schemes. The spread of updraft velocity is the combination of both low-level pressure perturbation gradient (PPG) and buoyancy. Both PPG and thermal buoyancy are small for simulations of weak convection but both are large for those of strong convection. Ice-related parameterizations contribute majorly to the spread of updraft velocity, while they are not the reason for the large spread of precipitation. The understandings gained in this study can help to focus future observations and parameterization development.

  20. Two-color cytofluorometry and cellular properties of the urokinase receptor associated with a human metastatic carcinomatous cell line

    International Nuclear Information System (INIS)

    Takahashi, K.; Gojobori, T.; Tanifuji, M.

    1991-01-01

    Purified human urokinase was labeled with either fluorescein isothiocyanate or iodine-125 and used as a probe for binding to the human metastatic carcinomatous cell line, Detroit 562. Cytofluorometry showed that the ligand bound preferentially to cells that had been exposed to acidic pH. The binding was competitive and decreased after mild tryptic digestion. The bound ligand could be removed by restoration of the cells to a low pH. Therefore, the cells had specific binding sites. The bound urokinase was involved in the breakdown of fibrin. Two-color cytofluorometric maps were constructed by counterstaining with propidium iodide. Results suggested that there were different cell populations that had different numbers of receptors and amounts of DNA. We cloned cells and found that single clones had homogeneous levels of receptors with different dissociation constants (from 10(-13) to 10(-11) mol/mg protein) for different clones. Cells of one clone, C5, which had high levels of receptor production, moved characteristically on a glass substratum coated with gold particles and reacted with wheat germ agglutinin, but not with concanavalin A. The receptors were found together with adhesion proteins at the sites where the cells adhered to the substrate. These results and the data obtained by zymography of the cellular proteins suggested that the urokinase-type plasminogen activators were bound to the receptors. The membrane-associated activator may stimulate local proteolysis, facilitating the migration of the tumor cell across the substrate

  1. Two-color cytofluorometry and cellular properties of the urokinase receptor associated with a human metastatic carcinomatous cell line

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, K.; Gojobori, T.; Tanifuji, M. (Shimane Medical Univ., Izumo (Japan))

    1991-02-01

    Purified human urokinase was labeled with either fluorescein isothiocyanate or iodine-125 and used as a probe for binding to the human metastatic carcinomatous cell line, Detroit 562. Cytofluorometry showed that the ligand bound preferentially to cells that had been exposed to acidic pH. The binding was competitive and decreased after mild tryptic digestion. The bound ligand could be removed by restoration of the cells to a low pH. Therefore, the cells had specific binding sites. The bound urokinase was involved in the breakdown of fibrin. Two-color cytofluorometric maps were constructed by counterstaining with propidium iodide. Results suggested that there were different cell populations that had different numbers of receptors and amounts of DNA. We cloned cells and found that single clones had homogeneous levels of receptors with different dissociation constants (from 10(-13) to 10(-11) mol/mg protein) for different clones. Cells of one clone, C5, which had high levels of receptor production, moved characteristically on a glass substratum coated with gold particles and reacted with wheat germ agglutinin, but not with concanavalin A. The receptors were found together with adhesion proteins at the sites where the cells adhered to the substrate. These results and the data obtained by zymography of the cellular proteins suggested that the urokinase-type plasminogen activators were bound to the receptors. The membrane-associated activator may stimulate local proteolysis, facilitating the migration of the tumor cell across the substrate.

  2. Microstructural Effects and Properties of Non-line-of-Sight Coating Processing via Plasma Spray-Physical Vapor Deposition

    Science.gov (United States)

    Harder, Bryan J.; Zhu, Dongming; Schmitt, Michael P.; Wolfe, Douglas E.

    2017-08-01

    Plasma spray-physical vapor deposition (PS-PVD) is a unique processing method that bridges the gap between conventional thermal spray and vapor phase methods, and enables highly tailorable coatings composed of a variety of materials in thin, dense layers or columnar microstructures with modification of the processing conditions. The strengths of this processing technique are material and microstructural flexibility, deposition speed, and potential for non-line-of-sight (NLOS) capability by vaporization of the feedstock material. The NLOS capability of PS-PVD is investigated here using yttria-stabilized zirconia and gadolinium zirconate, which are materials of interest for turbine engine applications. PS-PVD coatings were applied to static cylindrical substrates approximately 6-19 mm in diameter to study the coating morphology as a function of angle. In addition, coatings were deposited on flat substrates under various impingement configurations. Impingement angle had significant effects on the deposition mode, and microscopy of coatings indicated that there was a shift in the deposition mode at approximately 90° from incidence on the cylindrical samples, which may indicate the onset of more turbulent flow and PVD-like growth. Coatings deposited at non-perpendicular angles exhibited a higher density and nearly a 2× improvement in erosion performance when compared to coatings deposited with the torch normal to the surface.

  3. How the Venom from the Ectoparasitoid Wasp Nasonia vitripennis Exhibits Anti-Inflammatory Properties on Mammalian Cell Lines

    Science.gov (United States)

    Danneels, Ellen L.; Gerlo, Sarah; Heyninck, Karen; Van Craenenbroeck, Kathleen; De Bosscher, Karolien; Haegeman, Guy; de Graaf, Dirk C.

    2014-01-01

    With more than 150,000 species, parasitoids are a large group of hymenopteran insects that inject venom into and then lay their eggs in or on other insects, eventually killing the hosts. Their venoms have evolved into different mechanisms for manipulating host immunity, physiology and behavior in such a way that enhance development of the parasitoid young. The venom from the ectoparasitoid Nasonia vitripennis inhibits the immune system in its host organism in order to protect their offspring from elimination. Since the major innate immune pathways in insects, the Toll and Imd pathways, are homologous to the NF-κB pathway in mammals, we were interested in whether a similar immune suppression seen in insects could be elicited in a mammalian cell system. A well characterized NF-κB reporter gene assay in fibrosarcoma cells showed a dose-dependent inhibition of NF-κB signaling caused by the venom. In line with this NF-κB inhibitory action, N. vitripennis venom dampened the expression of IL-6, a prototypical proinflammatory cytokine, from LPS-treated macrophages. The venom also inhibited the expression of two NF-κB target genes, IκBα and A20, that act in a negative feedback loop to prevent excessive NF-κB activity. Surprisingly, we did not detect any effect of the venom on the early events in the canonical NF-κB activation pathway, leading to NF-κB nuclear translocation, which was unaltered in venom-treated cells. The MAP kinases ERK, p38 and JNK are other crucial regulators of immune responses. We observed that venom treatment did not affect p38 and ERK activation, but induced a prolonged JNK activation. In summary, our data indicate that venom from N. vitripennis inhibits NF-κB signaling in mammalian cells. We identify venom-induced up regulation of the glucocorticoid receptor-regulated GILZ as a most likely molecular mediator for this inhibition. PMID:24821138

  4. Clearance of Human IgG1-Sensitised Red Blood Cells In Vivo in Humans Relates to the In Vitro Properties of Antibodies from Alternative Cell Lines

    Science.gov (United States)

    Armour, Kathryn L.; Smith, Cheryl S.; Ip, Natasha C. Y.; Ellison, Cara J.; Kirton, Christopher M.; Wilkes, Anthony M.; Williamson, Lorna M.; Clark, Michael R.

    2014-01-01

    We previously produced a recombinant version of the human anti-RhD antibody Fog-1 in the rat myeloma cell line, YB2/0. When human, autologous RhD-positive red blood cells (RBC) were sensitised with this IgG1 antibody and re-injected, they were cleared much more rapidly from the circulation than had been seen earlier with the original human-mouse heterohybridoma-produced Fog-1. Since the IgG have the same amino acid sequence, this disparity is likely to be due to alternative glycosylation that results from the rat and mouse cell lines. By comparing the in vitro properties of YB2/0-produced Fog-1 IgG1 and the same antibody produced in the mouse myeloma cell line NS0, we now have a unique opportunity to pinpoint the cause of the difference in ability to clear RBC in vivo. Using transfected cell lines that express single human FcγR, we showed that IgG1 made in YB2/0 and NS0 cell lines bound equally well to receptors of the FcγRI and FcγRII classes but that the YB2/0 antibody was superior in FcγRIII binding. When measuring complexed IgG binding, the difference was 45-fold for FcγRIIIa 158F, 20-fold for FcγRIIIa 158V and approximately 40-fold for FcγRIIIb. The dissimilarity was greater at 100-fold in monomeric IgG binding assays with FcγRIIIa. When used to sensitise RBC, the YB2/0 IgG1 generated 100-fold greater human NK cell antibody-dependent cell-mediated cytotoxicity and had a 103-fold advantage over the NS0 antibody in activating NK cells, as detected by CD54 levels. In assays of monocyte activation and macrophage adherence/phagocytosis, where FcγRI plays major roles, RBC sensitised with the two antibodies produced much more similar results. Thus, the alternative glycosylation profiles of the Fog-1 antibodies affect only FcγRIII binding and FcγRIII-mediated functions. Relating this to the in vivo studies confirms the importance of FcγRIII in RBC clearance. PMID:25302805

  5. Clearance of human IgG1-sensitised red blood cells in vivo in humans relates to the in vitro properties of antibodies from alternative cell lines.

    Directory of Open Access Journals (Sweden)

    Kathryn L Armour

    Full Text Available We previously produced a recombinant version of the human anti-RhD antibody Fog-1 in the rat myeloma cell line, YB2/0. When human, autologous RhD-positive red blood cells (RBC were sensitised with this IgG1 antibody and re-injected, they were cleared much more rapidly from the circulation than had been seen earlier with the original human-mouse heterohybridoma-produced Fog-1. Since the IgG have the same amino acid sequence, this disparity is likely to be due to alternative glycosylation that results from the rat and mouse cell lines. By comparing the in vitro properties of YB2/0-produced Fog-1 IgG1 and the same antibody produced in the mouse myeloma cell line NS0, we now have a unique opportunity to pinpoint the cause of the difference in ability to clear RBC in vivo. Using transfected cell lines that express single human FcγR, we showed that IgG1 made in YB2/0 and NS0 cell lines bound equally well to receptors of the FcγRI and FcγRII classes but that the YB2/0 antibody was superior in FcγRIII binding. When measuring complexed IgG binding, the difference was 45-fold for FcγRIIIa 158F, 20-fold for FcγRIIIa 158V and approximately 40-fold for FcγRIIIb. The dissimilarity was greater at 100-fold in monomeric IgG binding assays with FcγRIIIa. When used to sensitise RBC, the YB2/0 IgG1 generated 100-fold greater human NK cell antibody-dependent cell-mediated cytotoxicity and had a 103-fold advantage over the NS0 antibody in activating NK cells, as detected by CD54 levels. In assays of monocyte activation and macrophage adherence/phagocytosis, where FcγRI plays major roles, RBC sensitised with the two antibodies produced much more similar results. Thus, the alternative glycosylation profiles of the Fog-1 antibodies affect only FcγRIII binding and FcγRIII-mediated functions. Relating this to the in vivo studies confirms the importance of FcγRIII in RBC clearance.

  6. Correlation of the crystal orientation and electrical properties of silicon thin films on glass crystallized by line focus diode laser

    Energy Technology Data Exchange (ETDEWEB)

    Yun, J., E-mail: j.yun@unsw.edu.au [School of Photovoltaic and Renewable Energy Engineering, University of New South Wales, Sydney, NSW 2052 (Australia); Huang, J.; Teal, A. [School of Photovoltaic and Renewable Energy Engineering, University of New South Wales, Sydney, NSW 2052 (Australia); Kim, K. [School of Photovoltaic and Renewable Energy Engineering, University of New South Wales, Sydney, NSW 2052 (Australia); Suntech R& D Australia, Botany, NSW 2019 (Australia); Varlamov, S.; Green, M.A. [School of Photovoltaic and Renewable Energy Engineering, University of New South Wales, Sydney, NSW 2052 (Australia)

    2016-06-30

    In this work, crystallographic orientation of polycrystalline silicon films on glass formed by continuous wave diode laser crystallization was studied. Most of the grain boundaries were coincidence lattice Σ3 twin boundaries and other types of boundaries such as, Σ6, Σ9, and Σ21 were also frequently observed. The highest photoluminescence signal and mobility were observed for a grain with (100) orientation in the normal direction. X-ray diffraction results showed the highest occupancies between 41 and 70% along the (110) orientation. However, the highest occupancies changed to (100) orientation when a 100 nm thick SiO{sub x} capping layer was applied. Suns-Voc measurement and photoluminescence showed that higher solar cell performance is obtained from the cell crystallized with the capping layer, which is suspected from increased occupancies of (100) orientation. - Highlights: • Linear grains parallel to the scan direction formed with high density. • Σ3 coincidence lattice (CSL) boundaries found inside a grain • Grain boundaries exhibit various CSL boundaries such as Σ9, Σ18, and Σ27. • Grain with < 100 > orientation in normal direction showed highest electrical properties. • Improved voltage observed when percentage of < 100 > normal orientation is increased.

  7. A global off-line model of size-resolved aerosol microphysics: I. Model development and prediction of aerosol properties

    Directory of Open Access Journals (Sweden)

    D. V. Spracklen

    2005-01-01

    Full Text Available A GLObal Model of Aerosol Processes (GLOMAP has been developed as an extension to the TOMCAT 3-D Eulerian off-line chemical transport model. GLOMAP simulates the evolution of the global aerosol size distribution using a sectional two-moment scheme and includes the processes of aerosol nucleation, condensation, growth, coagulation, wet and dry deposition and cloud processing. We describe the results of a global simulation of sulfuric acid and sea spray aerosol. The model captures features of the aerosol size distribution that are well established from observations in the marine boundary layer and free troposphere. Modelled condensation nuclei (CN>3nm vary between about 250–500 cm-3 in remote marine boundary layer regions and are generally in good agreement with observations. Modelled continental CN concentrations are lower than observed, which may be due to lack of some primary aerosol sources or the neglect of nucleation mechanisms other than binary homogeneous nucleation of sulfuric acid-water particles. Remote marine CN concentrations increase to around 2000–10 000 cm (at standard temperature and pressure in the upper troposphere, which agrees with typical observed vertical profiles. Cloud condensation nuclei (CCN at 0.2% supersaturation vary between about 1000 cm-3 in polluted regions and between 10 and 500 cm-3 in the remote marine boundary layer. New particle formation through sulfuric acid-water binary nucleation occurs predominantly in the upper troposphere, but the model results show that these particles contribute greatly to aerosol concentrations in the marine boundary layer. For this sulfur-sea salt system it is estimated that sea spray emissions account for only ~10% of CCN in the tropical marine boundary layer, but between 20 and 75% in the mid-latitude Southern Ocean. In a run with only natural sulfate and sea salt emissions the global mean surface CN concentration is more than 60% of that from a run with 1985 anthropogenic

  8. Efficacy of melatonin, IL-25 and siIL-17B in tumorigenesis-associated properties of breast cancer cell lines.

    Science.gov (United States)

    Gelaleti, Gabriela Bottaro; Borin, Thaiz Ferraz; Maschio-Signorini, Larissa Bazela; Moschetta, Marina Gobbe; Jardim-Perassi, Bruna Victorasso; Calvinho, Guilherme Berto; Facchini, Mariana Castilho; Viloria-Petit, Alicia M; de Campos Zuccari, Debora Aparecida Pires

    2017-08-15

    Mammary tumorigenesis can be modulated by melatonin, which has oncostatic action mediated by multiple mechanisms, including the inhibition of the activity of transcription factors such as NF-κB and modulation of interleukins (ILs) expression. IL-25 is an active cytokine that induces apoptosis in tumor cells due to differential expression of its receptor (IL-17RB). IL-17B competes with IL-25 for binding to IL-17RB in tumor cells, promoting tumorigenesis. This study purpose is to address the possibility of engaging IL-25/IL-17RB signaling to enhance the effect of melatonin on breast cancer cells. Breast cancer cell lines were cultured monolayers and 3D structures and treated with melatonin, IL-25, siIL-17B, each alone or in combination. Cell viability, gene and protein expression of caspase-3, cleaved caspase-3 and VEGF-A were performed by qPCR and immunofluorescence. In addition, an apoptosis membrane array was performed in metastatic cells. Treatments with melatonin and IL-25 significantly reduced tumor cells viability at 1mM and 1ng/mL, respectively, but did not alter cell viability of a non-tumorigenic epithelial cell line (MCF-10A). All treatments, alone and combined, significantly increased cleaved caspase-3 in tumor cells grown as monolayers and 3D structures (pmelatonin treatment. All treatments reduced VEGF-A protein expression in tumor cells (pmelatonin and IL-25-driven signaling in breast cancer cells. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. γ-Synuclein confers both pro-invasive and doxorubicin-mediated pro-apoptotic properties to the colon adenocarcinoma LS 174T cell line.

    Science.gov (United States)

    Goh, Kai-Wey; Say, Yee-How

    2015-09-01

    γ-synuclein, a neuronal protein of the synuclein family, is involved in carcinogenesis. To investigate its role in colorectal cancer carcinogenesis, we overexpressed γ-synuclein in LS 174T colon adenocarcinoma cell line (termed LS 174T-γsyn). When compared with untransfected/mock transfectants, LS 174T-γsyn had higher mobility in scratch wound assay, tend to scatter more in cell-scattering assay, and had enhanced lamellipodia and filopodia formation in cell-spreading assay. Enhanced adhesion of LS 174T-γsyn to fibronectin and collagen and significantly higher proliferation rate showed that γ-synuclein was able to increase extracellular matrix interaction and promoted proliferation of LS 174T. Higher invasiveness of LS 174T-γsyn was evidenced by enhanced invasion to the bottom of the basement membrane in Boyden chamber assay. However, LS 174T-γsyn were significantly more vulnerable to doxorubicin, vincristine and hydrogen peroxide insults, via apoptotic cell death. LS 174T-γsyn also had reduced anchorage-independent growth as shown by reduced colony formation and reduced anoikis resistance. We found that overexpression of γ-synuclein confers both pro-invasive and doxorubicin-mediated pro-apoptotic properties to LS 174T, where the former was mediated through enhanced cyclic adenosine monophosphate response element binding protein (CREB) phosphorylation, while the latter involved hepatocyte growth factor (HGF) downregulation and subsequent downstream signalling pathways possibly involving extracellular signal-regulated kinases (ERK)1/2, p38α, c-Jun N-terminal kinase (JNK) pan and Signal Transducers and Activators of Transcription (STATs). This unexpected contrasting finding as compared to other similar studies on colon cancer cell lines might be correlated with the degree of tumour advancement from which the cell lines were derived from.

  10. Dough properties and bread-making quality-related characteristics of Yumechikara near-isogenic wheat lines carrying different Glu-B3 alleles.

    Science.gov (United States)

    Ito, Miwako; Maruyama-Funatsuki, Wakako; Ikeda, Tatsuya M; Nishio, Zenta; Nagasawa, Koichi; Tabiki, Tadashi

    2015-06-01

    We investigated the relationships of three allelic variations in Glu-B3 (ab, g, and h) with dough properties and bread-making quality-related characteristics using near-isogenic lines (NILs) of 'Yumechikara' that commonly carry Glu-A1a, Glu-B1b, Glu-D1d, Glu-A3f, Glu-B3ab and Glu-D3a. Measurement of peak time (PT) in a 2-g mixograph indicated that Glu-B3g was the most effective for a strong dough property, followed by Glu-B3ab, with Glu-B3h being the least effective. The results of measurement of mixing time during bread-making were similar to those for PTs, i.e., the lines carrying Glu-B3g showed the longest mixing time, followed by those of Glu-B3ab, and those of Glu-B3h showed the shortest mixing time. Since two parameters of bread-making quality, loaf volume (LV) and specific loaf volume (SLV), were affected by flour protein contents in all groups of the Glu-B3 genotype, we compared the effects of the three Glu-B3 alleles on those parameters using analysis of covariance (ANCOVA) to remove the effect of protein content. The results indicated that the Glu-B3h group showed the largest SLV, followed by the Glu-B3ab group, and the Glu-B3g group showed the smallest SLV. These results suggest that the introduction of Glu-B3h into 'Yumechikara' makes it possible to breed varieties with good bread-making quality-related characteristics.

  11. The influence of Glu-1 and Glu-3 loci on dough rheology and bread-making properties in wheat (Triticum aestivum L.) doubled haploid lines.

    Science.gov (United States)

    Langner, Monika; Krystkowiak, Karolina; Salmanowicz, Bolesław P; Adamski, Tadeusz; Krajewski, Paweł; Kaczmarek, Zygmunt; Surma, Maria

    2017-12-01

    The major determinants of wheat quality are Glu-1 and Glu-3 glutenin loci and environmental factors. Additive effects of alleles at the Glu-1 and Glu-3 loci, as well as their interactions, were evaluated for dough rheology and baking properties in four groups of wheat doubled haploid lines differing in high- and low-molecular-weight glutenin composition. Flour quality, Reomixer (Reologica Instruments, Lund, Sweden), dough extension, Farinograph (Brabender GmbH, Duisburg, Germany) and baking parameters were determined. Groups of lines with the alleles Glu-A3b and Glu-B3d were characterized by higher values of dough and baking parameters compared to those with the Glu-A3e and Glu-B3a alleles. Effects of interactions between allelic variants at the Glu-1 and Glu-3 loci on Reomixer parameters, dough extension tests and baking parameters were significant, although additive effects of individual alleles were not always significant. The allelic variants at Glu-B3 had a much greater effect on dough rheological parameters than the variants at Glu-A3 or Glu-D3 loci. The effect of allelic variations at the Glu-D3 loci on rheological parameters and bread-making quality was non-significant, whereas their interactions with a majority of alleles at the other Glu-1 × Glu-3 loci were significant. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  12. Cognitive reserve in aging.

    Science.gov (United States)

    Tucker, A M; Stern, Y

    2011-06-01

    Cognitive reserve explains why those with higher IQ, education, occupational attainment, or participation in leisure activities evidence less severe clinical or cognitive changes in the presence of age-related or Alzheimer's disease pathology. Specifically, the cognitive reserve hypothesis is that individual differences in how tasks are processed provide reserve against brain pathology. Cognitive reserve may allow for more flexible strategy usage, an ability thought to be captured by executive functions tasks. Additionally, cognitive reserve allows individuals greater neural efficiency, greater neural capacity, and the ability for compensation via the recruitment of additional brain regions. Taking cognitive reserve into account may allow for earlier detection and better characterization of age-related cognitive changes and Alzheimer's disease. Importantly, cognitive reserve is not fixed but continues to evolve across the lifespan. Thus, even late-stage interventions hold promise to boost cognitive reserve and thus reduce the prevalence of Alzheimer's disease and other age-related problems.

  13. New platinum (II) and palladium (II) complexes of coumarin-thiazole Schiff base with a fluorescent chemosensor properties: Synthesis, spectroscopic characterization, X-ray structure determination, in vitro anticancer activity on various human carcinoma cell lines and computational studies.

    Science.gov (United States)

    Şahin, Ömer; Özdemir, Ümmühan Özmen; Seferoğlu, Nurgül; Genc, Zuhal Karagöz; Kaya, Kerem; Aydıner, Burcu; Tekin, Suat; Seferoğlu, Zeynel

    2018-01-01

    A new coumarin-thiazole based Schiff base (Ligand, L) and its Pd(II), Pt(II) complexes; ([Pd(L) 2 ] and [Pt(L) 2 ]), were synthesized and characterized using spectrophotometric techniques (NMR, IR, UV-vis, LC-MS), magnetic moment, and conductivity measurements. A single crystal X-ray analysis for only L was done. The crystals of L have monoclinic crystal system and P21/c space group. To gain insight into the structure of L and its complexes, we used density functional theory (DFT) method to optimize the molecules. The photophysical properties changes were observed after deprotonation of L with CN - via intermolecular charge transfer (ICT). Additionally, as the sensor is a colorimetric and fluorimetric cyanide probe containing active sites such as coumarin-thiazole and imine (CH=N), it showed fast color change from yellow to deep red in the visible region, and yellow fluorescence after CN - addition to the imine bond, in DMSO. The reaction mechanisms of L with CN - , F - and AcO - ions were evaluated using 1 H NMR shifts. The results showed that, the reaction of L with CN - ion was due to the deprotonation and addition mechanisms at the same time. The anti-cancer activity of L and its Pd(II) and Pt(II) complexes were evaluated in vitro using MTT assay on the human cancer lines MCF-7 (human breast adenocarcinoma), LS174T (human colon carcinoma), and LNCAP (human prostate adenocarcinoma). The anti-cancer effects of L and its complexes, on human cells, were determined by comparing the half maximal inhibitory concentration (IC 50 ) values. The activity results showed that, the Pd(II) complex of L has higher anti-tumor effect than L and its Pt(II) complex against the tested human breast adenocarcinoma (MCF-7), human prostate adenocarcinoma (LNCAP), and human colon carcinoma (LS174T) cell lines. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Cell-wall properties contributing to improved deconstruction by alkaline pre-treatment and enzymatic hydrolysis in diverse maize (Zea mays L.) lines.

    Science.gov (United States)

    Li, Muyang; Heckwolf, Marlies; Crowe, Jacob D; Williams, Daniel L; Magee, Timothy D; Kaeppler, Shawn M; de Leon, Natalia; Hodge, David B

    2015-07-01

    A maize (Zea mays L. subsp. mays) diversity panel consisting of 26 maize lines exhibiting a wide range of cell-wall properties and responses to hydrolysis by cellulolytic enzymes was employed to investigate the relationship between cell-wall properties, cell-wall responses to mild NaOH pre-treatment, and enzymatic hydrolysis yields. Enzymatic hydrolysis of the cellulose in the untreated maize was found to be positively correlated with the water retention value, which is a measure of cell-wall susceptibility to swelling. It was also positively correlated with the lignin syringyl/guaiacyl ratio and negatively correlated with the initial cell-wall lignin, xylan, acetate, and p-coumaric acid (pCA) content, as well as pCA released from the cell wall by pre-treatment. The hydrolysis yield following pre-treatment exhibited statistically significant negative correlations to the lignin content after pre-treatment and positive correlations to the solubilized ferulic acid and pCA. Several unanticipated results were observed, including a positive correlation between initial lignin and acetate content, lack of correlation between acetate content and initial xylan content, and negative correlation between each of these three variables to the hydrolysis yields for untreated maize. Another surprising result was that pCA release was negatively correlated with hydrolysis yields for untreated maize and, along with ferulic acid release, was positively correlated with the pre-treated maize hydrolysis yields. This indicates that these properties that may negatively contribute to the recalcitrance in untreated cell walls may positively contribute to their deconstruction by alkaline pre-treatment. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  15. Properties of Dense Cores Embedded in Musca Derived from Extinction Maps and {sup 13}CO, C{sup 18}O, and NH{sub 3} Emission Lines

    Energy Technology Data Exchange (ETDEWEB)

    Machaieie, Dinelsa A.; Vilas-Boas, José W.; Wuensche, Carlos A. [Instituto Nacional de Pesquisas Espaciais, Av. dos Astronautas 1.758—Jardim da Granja, CEP-12227-010, São José dos Campos, SP (Brazil); Racca, Germán A. [Universidade do Estado do Rio Grande do Norte, Faculdade de Ciências Exatas e Naturais/Depto. de Física, Campus Universitário Central, Setor II BR 110, KM 48, Rua Prof. António Campos, Costa e Silva 59610-090—Mossoró-RN (Brazil); Myers, Philip C. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Hickel, Gabriel R., E-mail: dinelsa.machaieie@inpe.br [Universidade Federal de Itajubá, Departamento de Física, Av. BPS, 1303, Pinheirinho, Itajubá, MG (Brazil)

    2017-02-10

    Using near-infrared data from the Two Micron All Sky Survey catalog and the Near Infrared Color Excess method, we studied the extinction distribution in five dense cores of Musca, which show visual extinction greater than 10 mag and are potential sites of star formation. We analyzed the stability in four of them, fitting their radial extinction profiles with Bonnor–Ebert isothermal spheres, and explored their properties using the J = 1–0 transition of {sup 13}CO and C{sup 18}O and the J = K = 1 transition of NH{sub 3}. One core is not well described by the model. The stability parameter of the fitted cores ranges from 4.5 to 5.7 and suggests that all cores are stable, including Mu13, which harbors one young stellar object (YSO), the IRAS 12322-7023 source. However, the analysis of the physical parameters shows that Mu13 tends to have larger A {sub V}, n {sub c}, and P {sub ext} than the remaining starless cores. The other physical parameters do not show any trend. It is possible that those are the main parameters to explore in active star-forming cores. Mu13 also shows the most intense emission of NH{sub 3}. Its {sup 13}CO and C{sup 18}O lines have double peaks, whose integrated intensity maps suggest that they are due to the superposition of clouds with different radial velocities seen in the line of sight. It is not possible to state whether these clouds are colliding and inducing star formation or are related to a physical process associated with the formation of the YSO.

  16. Inhibitiory properties of cytoplasmic extract of Lactobacilli isolated from common carp intestine on human chronic myelocytic leukemia K562 cell line: an in vitro study

    Directory of Open Access Journals (Sweden)

    Kabiri F

    2011-03-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 st1":*{behavior:url(#ieooui } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Lactobacillus species are genetically diverse groups of Lactic Acid Bacteria (LAB that have been introduced as probiotics, because of some characteristics such as their anti-tumor properties, helping the intestinal flora balance, production of antibiotics, stimulation of host immune response, etc. The aim of this study was to investigate the effects of cytoplasmic extraction and cell wall of Lactobacillus species isolated from the intestine of common carp on human chronic myelocytic leukemia or K562 cancer cell lines."n"nMethods: The intestinal contents of 115 common carp captured from the natural resources of West Azerbaijan province in Iran were examined for LAB. After isolation, the identification of Lactobacilli was done according to traditional and molecular bacteriological tests. Subsequently, a suspension of each bacterium was prepared and the protein content of the cytoplasm was extracted. Cell wall disintegration was done by cell lysis buffer and sonication. The effects of cytoplasmic extraction and cell wall on K562 cell line proliferation were investigated by MTT assays."n"nResults: The cytoplasmic extraction of the isolated Lactobacilli had significant (p<0.05 anti

  17. COGNITIVE RESERVE IN AGING

    Science.gov (United States)

    Tucker, Adrienne M.; Stern, Yaakov

    2011-01-01

    Cognitive reserve explains why those with higher IQ, education, occupational attainment, or participation in leisure activities evidence less severe clinical or cognitive changes in the presence of age-related or Alzheimer’s disease pathology. Specifically, the cognitive reserve hypothesis is that individual differences in how tasks are processed provide reserve against brain pathology. Cognitive reserve may allow for more flexible strategy usage, an ability thought to be captured by executive functions tasks. Additionally, cognitive reserve allows individuals greater neural efficiency, greater neural capacity, and the ability for compensation via the recruitment of additional brain regions. Taking cognitive reserve into account may allow for earlier detection and better characterization of age-related cognitive changes and Alzheimer’s disease. Importantly, cognitive reserve is not fixed but continues to evolve across the lifespan. Thus, even late-stage interventions hold promise to boost cognitive reserve and thus reduce the prevalence of Alzheimer’s disease and other age-related problems. PMID:21222591

  18. HYDROCARBONS RESERVES IN VENEZUELA

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Cruz, D.J.

    2007-07-01

    Venezuela is an important player in the energy world, because of its hydrocarbons reserves. The process for calculating oil and associated gas reserves is described bearing in mind that 90% of the gas reserves of Venezuela are associated to oil. Likewise, an analysis is made of the oil reserves figures from 1975 to 2003. Reference is also made to inconsistencies found by international experts and the explanations offered in this respect by the Ministry of Energy and Petroleum (MENPET) and Petroleos de Venezuela (PDVSA) regarding the changes that took place in the 1980s. In turn, Hubbert's Law is explained to determine peak production of conventional oil that a reservoir or field will reach, as well as its relationship with remaining reserves. Emphasis is placed on the interest of the United Nations on this topic. The reserves of associated gas are presented along with their relationship with the different crude oils that are produced and with injected gas, as well as with respect to the possible changes that would take place in the latter if oil reserves are revised. Some recommendations are submitted so that the MENPET starts preparing the pertinent policies ruling reserves. (auth)

  19. Ovarian reserve parameters

    DEFF Research Database (Denmark)

    Bentzen, J G; Forman, Julie Lyng; Pinborg, Anja

    2012-01-01

    2-5 of the menstrual cycle or during withdrawal bleeding, blood sampling and transvaginal sonography was performed. After adjusting for age, ovarian reserve parameters were lower among users than among non-users of hormonal contraception: serum AMH concentration by 29.8% (95% CI 19.9 to 38...... was observed between duration of hormonal-contraception use and ovarian reserve parameters. No dose-response relation was found between the dose of ethinyloestradiol and AMH or AFC. This study indicates that ovarian reserve markers are lower in women using sex steroids for contraception. Thus, AMH...... concentration and AFC may not retain their accuracy as predictors of ovarian reserve in women using hormonal contraception. Serum anti-Müllerian hormone (AMH) concentration is an indirect marker of the number of small follicles in the ovary and thereby the ovarian reserve. The AMH concentration is now widely...

  20. EFFECT OF Na₂B₄O₇ ADDITION ON THE STRUCTURE AND PROPERTIES OF Al₂O₃ CERAMIC-LINED STEEL PIPE PREPARED BY THE GS-SHS METHOD

    Directory of Open Access Journals (Sweden)

    Xinghui Hou

    2017-12-01

    Full Text Available By adding Na₂B₄O₇ into the Al-Fe₂O₃-Cr₂O₃ reaction system, the Al₂O₃ ceramic-lined steel pipe was prepared with the gravitational separation SHS method, and the influence of the Na₂B₄O₇ addition on the structure and properties of the produced composite steel pipe was investigated. The obtained results showed that the phase composition of the ceramic coating was Al₂O₃-FeCr Alloy-(Al0.9Cr0.1₂O₃ composite, and with the increase of the amount of Na₂B₄O₇ addition, the Fe-Cr alloy particles left in the ceramic coating increased and distributed uniformly, and the denser ceramic coating was obtained. However, when the amount of Na₂B₄O₇ addition increased further to over 4%, the ceramic coating became fractures, the hardness of ceramic coating decreased. The transition structure of steel pipe-transition layer-ceramic coating was formed, the thickness of the transition layer decreased with the addition of Na₂B₄O₇, and the boundaries between the transition layer and the ceramic layer were less obvious, which would have a significant effect on the improvement of the bonding quality of the composite steel pipe.

  1. The effects of hibernation on the contractile and biochemical properties of skeletal muscles in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus.

    Science.gov (United States)

    James, Rob S; Staples, James F; Brown, Jason C L; Tessier, Shannon N; Storey, Kenneth B

    2013-07-15

    Hibernation is a crucial strategy of winter survival used by many mammals. During hibernation, thirteen-lined ground squirrels, Ictidomys tridecemlineatus, cycle through a series of torpor bouts, each lasting more than a week, during which the animals are largely immobile. Previous hibernation studies have demonstrated that such natural models of skeletal muscle disuse cause limited or no change in either skeletal muscle size or contractile performance. However, work loop analysis of skeletal muscle, which provides a realistic assessment of in vivo power output, has not previously been undertaken in mammals that undergo prolonged torpor during hibernation. In the present study, our aim was to assess the effects of 3 months of hibernation on contractile performance (using the work loop technique) and several biochemical properties that may affect performance. There was no significant difference in soleus muscle power output-cycle frequency curves between winter (torpid) and summer (active) animals. Total antioxidant capacity of gastrocnemius muscle was 156% higher in torpid than in summer animals, suggesting one potential mechanism for maintenance of acute muscle performance. Soleus muscle fatigue resistance was significantly lower in torpid than in summer animals. Gastrocnemius muscle glycogen content was unchanged. However, state 3 and state 4 mitochondrial respiration rates were significantly suppressed, by 59% and 44%, respectively, in mixed hindlimb skeletal muscle from torpid animals compared with summer controls. These findings in hindlimb skeletal muscles suggest that, although maximal contractile power output is maintained in torpor, there is both suppression of ATP production capacity and reduced fatigue resistance.

  2. Skyline Reservation System

    Data.gov (United States)

    US Agency for International Development — Flight reservation application used for in-country flights by USAID and DoS staff in Afghanistan. The application is managed and maintained by the vendor and USAID...

  3. Property (

    CERN Document Server

    Ershov, Mikhail; Kassabov, Martin

    2017-01-01

    The authors introduce and study the class of groups graded by root systems. They prove that if \\Phi is an irreducible classical root system of rank \\geq 2 and G is a group graded by \\Phi, then under certain natural conditions on the grading, the union of the root subgroups is a Kazhdan subset of G. As the main application of this theorem the authors prove that for any reduced irreducible classical root system \\Phi of rank \\geq 2 and a finitely generated commutative ring R with 1, the Steinberg group {\\mathrm St}_{\\Phi}(R) and the elementary Chevalley group \\mathbb E_{\\Phi}(R) have property (T). They also show that there exists a group with property (T) which maps onto all finite simple groups of Lie type and rank \\geq 2, thereby providing a "unified" proof of expansion in these groups.

  4. Lithium reserves and resources

    International Nuclear Information System (INIS)

    Evans, R.K.

    1978-01-01

    As a result of accelerating research efforts in the fields of secondary batteries and thermonuclear power generation, concern has been expressed in certain quarters regarding the availability, in sufficient quantities, of lithium. As part of a recent study by the National Research Council on behalf of the Energy Research and Development Administration, a subpanel was formed to consider the outlook for lithium. Principal areas of concern were reserves, resources and the 'surplus' available for energy applications after allowing for the growth in current lithium applications. Reserves and resources were categorized into four classes ranging from fully proved reserves to resources which are probably dependent upon the marketing of co-products to become economically attractive. Because of the proprietary nature of data on beneficiation and processing recoveries, the tonnages of available lithium are expressed in terms of plant feed. However, highly conservative assumptions have been made concerning mining recoveries and these go a considerable way to accounting for total losses. Western World reserves and resources of all classes are estimated at 10.6 million tonnes Li of which 3.5 million tonnes Li are located in the United States. Current United States capacity, virtually equivalent to Western World capacity, is 4700 tonnes Li and production in 1976 approximated to 3500 tonnes Li. Production for current applications is expected to grow to approx. 10,000 tonnes in year 2000 and 13,000 tonnes a decade later. The massive excess of reserves and resources over that necessary to support conventional requirements has limited the amount of justifiable exploration expenditures; on the last occasion, there was a a major increase in demand (by the USAEA) reserves and capacity were increased rapidly. There are no foreseeable reasons why this shouldn't happen again when the need is clear. (author)

  5. Analysis of some coplanar transmission lines: coplanar coupled lines, coplanar coupled striplines, and coplanar coupled lines with rectangular microshield

    Science.gov (United States)

    Yuan, Naichang; He, Jianguo; Yao, Demiao; Dai, Qin; Lin, Weigan

    1995-06-01

    Two types of coplanar transmission lines, rectangular microshield coplanar coupled lines (RMCCL) and coplanar coupled rectangular microshield lines (CCRML), are proposed for MMIC applications. These are developed from coplanar coupled lines (CCL) and coplanar coupled strip lines (CCS). Analytic formulas are presented for calculating the quasistatic TEM parameters of these coupled lines by means of exact conformal mapping techniques. Numerical results are also presented to illustrate the properties of these coplanar transmission lines.

  6. Comparative fiber property and transcriptome analyses reveal key genes potentially related to high fiber strength in cotton (Gossypium hirsutum L.) line MD52ne.

    Science.gov (United States)

    Islam, Md S; Fang, David D; Thyssen, Gregory N; Delhom, Chris D; Liu, Yongliang; Kim, Hee Jin

    2016-02-01

    Individual fiber strength is an important quality attribute that greatly influences the strength of the yarn spun from cotton fibers. Fiber strength is usually measured from bundles of fibers due to the difficulty of reliably measuring strength from individual cotton fibers. However, bundle fiber strength (BFS) is not always correlated with yarn strength since it is affected by multiple fiber properties involved in fiber-to-fiber interactions within a bundle in addition to the individual fiber strength. Molecular mechanisms responsible for regulating individual fiber strength remain unknown. Gossypium hirsutum near isogenic lines (NILs), MD52ne and MD90ne showing variations in BFS provide an opportunity for dissecting the regulatory mechanisms involved in individual fiber strength. Comprehensive fiber property analyses of the NILs revealed that the superior bundle strength of MD52ne fibers resulted from high individual fiber strength with minor contributions from greater fiber length. Comparative transcriptome analyses of the NILs showed that the superior bundle strength of MD52ne fibers was potentially related to two signaling pathways: one is ethylene and the interconnected phytohormonal pathways that are involved in cotton fiber elongation, and the other is receptor-like kinases (RLKs) signaling pathways that are involved in maintaining cell wall integrity. Multiple RLKs were differentially expressed in MD52ne fibers and localized in genomic regions encompassing the strength quantitative trait loci (QTLs). Several candidate genes involved in crystalline cellulose assembly were also up-regulated in MD52ne fibers while the secondary cell wall was produced. Comparative phenotypic and transcriptomic analyses revealed differential expressions of the genes involved in crystalline cellulose assembly, ethylene and RLK signaling pathways between the MD52ne and MD90ne developing fibers. Ethylene and its phytohormonal network might promote the elongation of MD52ne fibers

  7. Ecotoxicological properties of ketoprofen and the S(+)-enantiomer (dexketoprofen): Bioassays in freshwater model species and biomarkers in fish PLHC-1 cell line.

    Science.gov (United States)

    Mennillo, Elvira; Arukwe, Augustine; Monni, Gianfranca; Meucci, Valentina; Intorre, Luigi; Pretti, Carlo

    2018-01-01

    The increased use of nonsteroidal anti-inflammatory drugs (NSAIDs) has resulted in their ubiquitous presence in the environment. The toxicological properties of these 2 widely prescribed NSAIDs, namely racemic ketoprofen and its enantiomer S(+)-ketoprofen (dexketoprofen), were evaluated, firstly, by acute and chronic toxicity tests using 3 representative model organisms (Vibrio fischeri, Pseudokirchneriella subcapitata, and Ceriodaphnia dubia) and, secondly, by evaluating the responses of biotransformation systems and multidrug resistance-associated proteins (MRP1/MRP2) using the Poeciliopsis lucida hepatocellular carcinoma 1 (PLHC-1) fish hepatic cell line. Toxicity data from both acute and chronic dexketoprofen exposure indicated higher sensitivity through inhibition of bioluminescence and algal growth and through increased mortality/immobilization compared to racemic ketoprofen exposure. The growth inhibition test showed that racemic ketoprofen and dexketoprofen exhibited different effect concentration values (240.2 and 65.6 μg/L, respectively). Furthermore, racemic ketoprofen and dexketoprofen did not exert cytotoxic effects in PLHC-1 cells and produced compound-, time-, and concentration-specific differential effects on cytochrome P450 1A (CYP1A) and glutathione S-transferase levels. For CYP1A, the effects of racemic ketoprofen and dexketoprofen differed at the transcriptional and catalytic levels. Exposure to racemic ketoprofen and dexketoprofen modulated MRP1 and MRP2 mRNA levels, and these effects were also dependent on compound, exposure time, and concentration of the individual drug. The present study revealed for the first time the interactions between these NSAIDs and key detoxification systems and different sensitivity to the racemic mixture compared to its enantiomer. Environ Toxicol Chem 2018;37:201-212. © 2017 SETAC. © 2017 SETAC.

  8. The Effect of Aloe vera Extract on Adherence of Candida albicans and Other Properties of Heat Cure Denture Soft Lining Material

    Directory of Open Access Journals (Sweden)

    Aseel Riyadh Abdulwahhab

    2018-03-01

    Full Text Available Objective: One of the serious drawbacks of denture soft lining materials is colonization by Candida albicans that might eventually leads to denture stomatitis. This can be treated either systemically or locally. With the recent increase interest in medicinal plants, this study aimed to evaluate the effect of Aloe vera powder incorporated with heat cure acrylic soft-liner powder on the adherence of Candida albicans, shear bond strength and tear strength. Methods: According to the results of pilot study, two percentages (3% and 10% of aloe vera powder was used. Candida adherence test, shear bond strength and tear strength tests were performed, also the long-term effect was evaluated after 2 and 4 weeks incubation in artificial saliva. All data was analyzed using SPSS software (version 24. Descriptive and inferential statistics, ANOVA test with post-hoc analysis was applied. Results: The results indicated that both concentrations of aloe vera showed a statistically highly significant decrease in Candida albicans cell count in comparison to control group, also a significant increase in shear bond strength and non-significant difference in tear strength of soft liner for the experimental groups. After 2 and 4 weeks incubation in artificial saliva, all experimental groups showed a statistically significant decrease in Candida albicans cell count and a statistically significant increase in shear bond strength and tear strength test. Conclusion: Incorporation of aloe vera powder with heat cure acrylic soft-liner powder helps to add an anti-candidal property to the soft liner, also this addition results in improvement in shear bond strength and tear strength.

  9. SUIKERBOSRAND NATURE RESERVE

    African Journals Online (AJOL)

    Suikerbosrand Nature Reserve and fts educational facilities are run by the Transvaal. Division of. Nature Conservation. ... tion and the education facilities provided. The former are utilized mainly by the general public ... artist Paul Bosman (already reviewed in the EEASA newsletter). The co-founders of the Foundation are.

  10. Session 7: Reserve

    International Nuclear Information System (INIS)

    Bailey, R.; Crockford, G.

    2001-01-01

    The reserve session was devoted to some issues that came up through the workshop, which were grouped into three main areas: The Global Accelerator Network, Problems of stress and how to get organized to minimize them, What should an operations group be responsible for? This paper summarizes the discussions that took place. (author)

  11. School Shootings Stun Reservation

    Science.gov (United States)

    Borja, Rhea R.; Cavanagh, Sean

    2005-01-01

    This article deals with the impact brought by the school shootings at Red Lake Indian Reservation in Minnesota to the school community. A deeply troubled 16-year-old student shot and killed seven other people and himself at a high school. The nation's deadliest school attack since the 1999 slayings at Colorado's suburban Columbine High School took…

  12. SUIKERBOSRAND NATURE RESERVE

    African Journals Online (AJOL)

    reserve, the total length being 66 km with six overnight huts. There are also the BokmakiePie. Nature Troil. and the Cheetah Interpretive Troil. which can be used by day visitors. The former has two loops, one of 10 km and another of 17 km. The. Cheetah Troil. is much shorter and various points of interest are interpreted en ...

  13. 26 CFR 1.46-10 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true [Reserved] 1.46-10 Section 1.46-10 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Rules for Computing Credit for Investment in Certain Depreciable Property § 1.46-10 [Reserved] ...

  14. Covariant electromagnetic field lines

    Science.gov (United States)

    Hadad, Y.; Cohen, E.; Kaminer, I.; Elitzur, A. C.

    2017-08-01

    Faraday introduced electric field lines as a powerful tool for understanding the electric force, and these field lines are still used today in classrooms and textbooks teaching the basics of electromagnetism within the electrostatic limit. However, despite attempts at generalizing this concept beyond the electrostatic limit, such a fully relativistic field line theory still appears to be missing. In this work, we propose such a theory and define covariant electromagnetic field lines that naturally extend electric field lines to relativistic systems and general electromagnetic fields. We derive a closed-form formula for the field lines curvature in the vicinity of a charge, and show that it is related to the world line of the charge. This demonstrates how the kinematics of a charge can be derived from the geometry of the electromagnetic field lines. Such a theory may also provide new tools in modeling and analyzing electromagnetic phenomena, and may entail new insights regarding long-standing problems such as radiation-reaction and self-force. In particular, the electromagnetic field lines curvature has the attractive property of being non-singular everywhere, thus eliminating all self-field singularities without using renormalization techniques.

  15. Study of the structure and properties of metal of the major steam lines of a CCGT-420 unit made from high-chromium X10CrMoVNb9-1 (P91) steel

    Science.gov (United States)

    Grin', E. A.; Anokhov, A. E.; Pchelintsev, A. V.; Krüger, E.-T.

    2016-07-01

    The technology of manufacture of live steam lines and hot reheat lines at FINOW Rohrsysteme GmbH are discussed. These pipelines are designed for high-performance CCGT units and are made from high-chromium martensitic steel X10CrMoVNb9-1 (P91). The principles of certification and evaluation of conformance of thermal and mechanical equipment made from new construction materials with the TRCU 032-2013 technical regulation of the Customs Union are detailed. The requirements outlined in Russian and international regulatory documents regarding the manufacture of pipes and semifinished products for pipeline systems are compared. The characteristic features of high-chromium martensitic steel, which define the requirements for its heat treatment and welding, are outlined. The methodology and the results of a comprehensive analysis of metal of pipes, fittings, and weld joints of steam lines are presented. It is demonstrated that the short-term mechanical properties of metal (P91 steel) of pipes, bends, and weld joints meet the requirements of European standards and Russian technical specifications. The experimental data on long-term strength of metal of pipes from a live steam line virtually match the corresponding reference curve from the European standard, while certain experimental points for metal of bends of this steam line and metal of pipes and bends from a hot reheat line lie below the reference curve, but they definitely stay within the qualifying (20%) interval of the scatter band. The presence of a weakened layer in the heat-affected zone of weld joints of steel P91 is established. It is shown that the properties of this zone govern the short-term and long-term strength of weld joints in general. The results of synthesis and analysis of research data support the notion that the certification testing of steam lines and other equipment made from chromium steels should necessarily involve the determination of long-term strength parameters.

  16. The Strategic Petroleum Reserve

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    The Strategic Petroleum Reserve program was set into motion by the 1975 Energy Policy and Conservation Act (EPCA). By 1990, 590 million barrels of oil had been placed in storage. Salt domes along the Gulf Coast offered ideal storage. Both sweet'' and sour'' crude oil have been acquired using various purchase options. Drawdown, sale, and distribution of the oil would proceed according to guidelines set by EPCA in the event of a severe energy supply disruption. (SM)

  17. Alocação de reserva legal em propriedades rurais: do cartesiano ao holístico Legal reserve allocation in rural properties: from the cartesian to the holistic

    Directory of Open Access Journals (Sweden)

    Hevandro C. Delalibera

    2008-06-01

    Full Text Available Ao exigir áreas de Preservação Permanente (APP e Reserva Legal (RL em todos os imóveis rurais do Brasil, o Código Florestal Brasileiro (Lei Federal 4771/1965 se reverte em um dos instrumentos mais importantes com o propósito de mitigar impactos ambientais das atividades agrícolas. Como em outros estados, no Paraná esta legislação também foi ignorada; para cumprir o disposto no Código Florestal e estipular prazo para as adequações necessárias, foi instituído o Sistema de Manutenção, Recuperação e Proteção da Reserva Legal e Áreas de Preservação Permanente - SISLEG (Decreto Estadual 387/1999. Com o objetivo de se analisar essas normativas, elaborou-se um estudo de imóvel rural típico dos Campos Gerais do Paraná e, com base em técnicas de sensoriamento remoto, se definiram as APPs e o montante necessário para compor a RL. Como a legislação não especifica critérios objetivos para a localização das RLs, duas perspectivas foram avaliadas: a maximização do potencial agrícola da propriedade e a conservação da natureza, com base no contexto ambiental e hidrográfico no qual o imóvel está inserido. Conclui-se que a legislação pode contribuir para mitigar impactos não contemplando, porém, conceitos importantes para o planejamento territorial e conservação da natureza.The Brazilian Forest Code (Federal Law 4771/1965, by defining Permanent Protection Areas (PPA and Legal Reserves (LR on every rural property in the country, is one of the most important measures to mitigate environmental impacts from farming activities. As in many other states, such legislation has been disregarded in Paraná. To comply with Forest Code requirements and define time limits for its accomplishment, the State of Paraná has enacted the System for Maintenance, Recovery and Protection for the Legal Reserve and Permanent Protection Areas - SISLEG (State Decree 3320/2004. This paper analises the accomplishment of this system in a

  18. [Hypertrophy and coronary reserve].

    Science.gov (United States)

    Motz, W; Scheler, S

    2008-12-01

    Left ventricular hypertrophy represents the structural mechanism of adaptation of the left ventricle as the answer of a chronic pressure overload in arterial hypertension. Initially an increment in left ventricular wall thickness occurs. In this stadium of "concentric hypertrophy" LV systolic wall stress, LV ejection fraction and myocardial oxygen consumption per weight unit myocardium remain unchanged. In the further time course of disease LV dilatation will be present. In this phase of "excentric hypertrophy" LV systolic wall stress and myocardial oxygen consumption per weight unit myocardium rise and LV ejection fraction decreases. Patients with arterial hypertension frequently complain of angina pectoris. Angina pectoris and the positive exercise tolerance test or the positive myocardial scintigraphy are the consequence of the impaired coronary flow reserve. The coronary flow reserve is diminished due to structural and functional changes of the coronary circulation. ACE-inhibitors and AT1-receptor blockers cause a significant improvement of coronary flow reserve and regression of both left ventricular hypertrophy and myocardial fibrosis.

  19. In vitro antiproliferative and apoptosis-inducing properties of a mononuclear copper(II) complex with dppz ligand, in two genotypically different breast cancer cell lines.

    Science.gov (United States)

    Dhivya, Rajakumar; Jaividhya, Paramasivam; Riyasdeen, Anvarbatcha; Palaniandavar, Mallayan; Mathan, Ganeshan; Akbarsha, Mohammad Abdulkader

    2015-10-01

    In the background that there is concerted effort to discover newer metal-based cancer chemotherapeutic agents that could overcome the limitations in cisplatin and that copper, a biocompatible and redox-active metal, offers potential as alternative to cisplatin, the present study was undertaken to investigate the in vitro anti-proliferative properties of the mononuclear copper(II)complex [Cu(L)(diimine)] + where LH = 2-[(2-dimethylaminoethylimino)methyl]phenol and diimine = dipyrido[3,2-a:2',3'-c]phenazine (dppz) using breast cancer cell lines MCF-7 (ER(+ve) and p53(WT)) and MDA-MB-231(ER(-ve) and p53(mutant)) when cisplatin was used as positive control. The complex affected the viability of both the cell lines in dose-as well as duration-dependent manner as revealed in the MTT assay. The 24 and 48 h IC50 of the complex were several times lesser than those of cisplatin, and within this huge difference the efficacy of the complex was much superior with MCF-7 cell compared to MDA-MB-231 cell. The cell death was preferentially apoptosis, though necrosis also occurred to a certain extent. These inferences were substantiated by AO/EB fluorescent staining, Hoechst staining, assessment of mitochondrial transmembrane potential, comet assay for DNA damage, DCFH assay for reactive oxygen species (ROS) generation and Western blot of apoptosis-related proteins. Thus, the copper(II) dppz complex under investigation is much more efficient than cisplatin in affecting viability of the breast cancer cells. The underlying mechanism appears to be DNA damage-primed (in view of the known intercalation mode of binding of the complex with DNA) and ROS-associated mitochondria-mediated intrinsic apoptosis to a great extent but necrosis also has a role to a certain extent, which may also be a PARP-mediated cell death independent of apoptosis. Within the purview of this conclusion, the results indicate that the ER and/or p53 genotypes have a bearing on the efficacy of the complex as a

  20. Characterization of Genotoxic Response to 15 Multiwalled Carbon Nanotubes with Variable Physicochemical Properties Including Surface Functionalizations in the FE1-Muta(TM) Mouse Lung Epithelial Cell Line

    DEFF Research Database (Denmark)

    Jackson, Petra; Kling, Kirsten; Jensen, Keld Alstrup

    2015-01-01

    Carbon nanotubes vary greatly in physicochemical properties. We compared cytotoxic and genotoxic response to 15 multiwalled carbon nanotubes (MWCNT) with varying physicochemical properties to identify drivers of toxic responses. The studied MWCNT included OECD Working Party on Manufactured Nanoma...

  1. Properties of internalization factors contributing to the uptake of extracellular DNA into tumor-initiating stem cells of mouse Krebs-2 cell line.

    Science.gov (United States)

    Dolgova, Evgeniya V; Potter, Ekaterina A; Proskurina, Anastasiya S; Minkevich, Alexandra M; Chernych, Elena R; Ostanin, Alexandr A; Efremov, Yaroslav R; Bayborodin, Sergey I; Nikolin, Valeriy P; Popova, Nelly A; Kolchanov, Nikolay A; Bogachev, Sergey S

    2016-05-25

    Previously, we demonstrated that poorly differentiated cells of various origins, including tumor-initiating stem cells present in the ascites form of mouse cancer cell line Krebs-2, are capable of naturally internalizing both linear double-stranded DNA and circular plasmid DNA. The method of co-incubating Krebs-2 cells with extracellular plasmid DNA (pUC19) or TAMRA-5'-dUTP-labeled polymerase chain reaction (PCR) product was used. It was found that internalized plasmid DNA isolated from Krebs-2 can be transformed into competent Escherichia coli cells. Thus, the internalization processes taking place in the Krebs-2 cell subpopulation have been analyzed and compared, as assayed by E. coli colony formation assay (plasmid DNA) and cytofluorescence (TAMRA-DNA). We showed that extracellular DNA both in the form of plasmid DNA and a PCR product is internalized by the same subpopulation of Krebs-2 cells. We found that the saturation threshold for Krebs-2 ascites cells is 0.5 μg DNA/10(6) cells. Supercoiled plasmid DNA, human high-molecular weight DNA, and 500 bp PCR fragments are internalized into the Krebs-2 tumor-initiating stem cells via distinct, non-competing internalization pathways. Under our experimental conditions, each cell may harbor 340-2600 copies of intact plasmid material, or up to 3.097 ± 0.044×10(6) plasmid copies (intact or not), as detected by quantitative PCR. The internalization dynamics of extracellular DNA, copy number of the plasmids taken up by the cells, and competition between different types of double-stranded DNA upon internalization into tumor-initiating stem cells of mouse ascites Krebs-2 have been comprehensively analyzed. Investigation of the extracellular DNA internalization into tumor-initiating stem cells is an important part of understanding their properties and possible destruction mechanisms. For example, a TAMRA-labeled DNA probe may serve as an instrument to develop a target for the therapy of cancer, aiming at elimination of

  2. Fractional Reserve Banking

    OpenAIRE

    Andreasen, Niels; Bjerregaard, Mads; Lund, Jonas; Olsen, Ove Bitsch; Rasmussen, Andreas Dalgas

    2012-01-01

    Projektet er bygget op omkring kritisk realisme, som er det gennemgående videnskabelige fundament til undersøgelsen af hvilke strukturelle grunde der er til finansiel ustabilitet i Danmark. Projektet går i dybden med Fractional Reserve Banking og incitamentsstrukturen i banksystemet. Vi bevæger os både på det makro- og mikroøkonomiske niveau i analysen. På makro niveau bruger vi den østrigske skole om konjunktur teori (The Positive Theory of the Cycle). På mikro niveau arbejder vi med princip...

  3. Human ESCs predisposition to karyotypic instability: Is a matter of culture adaptation or differential vulnerability among hESC lines due to inherent properties?

    Directory of Open Access Journals (Sweden)

    Bueno Clara

    2008-10-01

    Full Text Available Abstract Background The use of human embryonic stem cells (hESCs in research is increasing and hESCs hold the promise for many biological, clinical and toxicological studies. Human ESCs are expected to be chromosomally stable since karyotypic changes represent a pitfall for potential future applications. Recently, several studies have analysed the genomic stability of several hESC lines maintained after prolonged in vitro culture but controversial data has been reported. Here, we prompted to compare the chromosomal stability of three hESC lines maintained in the same laboratory using identical culture conditions and passaging methods. Results Molecular cytogenetic analyses performed in three different hESC lines maintained in parallel in identical culture conditions revealed significant differences among them in regard to their chromosomal integrity. In feeders, the HS181, SHEF-1 and SHEF-3 hESC lines were chromosomally stable up to 185 passages using either mechanical or enzymatic dissection methods. Despite the three hESC lines were maintained under identical conditions, each hESC line behaved differently upon being transferred to a feeder-free culture system. The two younger hESC lines, HS181 (71 passages and SHEF-3 (51 passages became chromosomally unstable shortly after being cultured in feeder-free conditions. The HS181 line gained a chromosome 12 by passage 17 and a marker by passage 21, characterized as a gain of chromosome 20 by SKY. Importantly, the mosaicism for trisomy 12 gradually increased up to 89% by passage 30, suggesting that this karyotypic abnormality provides a selective advantage. Similarly, the SHEF-3 line also acquired a trisomy of chromosome 14 as early as passage 10. However, this karyotypic aberration did not confer selective advantage to the genetically abnormal cells within the bulk culture and the level of mosaicism for the trisomy 14 remained overtime between 15%–36%. Strikingly, however, a much older hESC line

  4. Clamp Restrains Pressure Line

    Science.gov (United States)

    Aliberti, J. A.

    1982-01-01

    Safety restraint protects people and property if a high-pressure fitting fails. As long as pressure line remains attached at the fitting, clamp exerts essentially no force on hose. If fitting fails, force of fluid leaving free end of hose causes the cam on the clamp to compress hose with a positive locking action.

  5. High Line

    DEFF Research Database (Denmark)

    Kiib, Hans

    2015-01-01

    . The High Line project has been carried out as part of an open conversion strategy. The result is a remarkable urban architectural project, which works as a catalyst for the urban development of Western Manhattan. The greater project includes the restoration and reuse of many old industrial buildings......At just over 10 meters above street level, the High Line extends three kilometers through three districts of Southwestern Manhattan in New York. It consists of simple steel construction, and previously served as an elevated rail line connection between Penn Station on 34th Street and the many...... in close proximity to the park bridge and new projects being added to fit the context. The outcome is a conglomeration of non-contemporary urban activities along the High Line, where mechanical workshops, small wholesale stores. etc. mix with new exclusive residential buildings, eminent cafés...

  6. World lines.

    OpenAIRE

    Waser Jürgen; Fuchs Raphael; Ribicic Hrvoje; Schindler Benjamin; Blöschl Günther; Gröller Eduard

    2010-01-01

    In this paper we present World Lines as a novel interactive visualization that provides complete control over multiple heterogeneous simulation runs. In many application areas decisions can only be made by exploring alternative scenarios. The goal of the suggested approach is to support users in this decision making process. In this setting the data domain is extended to a set of alternative worlds where only one outcome will actually happen. World Lines integrate simulation visualization and...

  7. Antiproliferative Properties Against Human Breast, Cervical and Ovarian Cancer Cell Lines, and Antioxidant Capacity of Leaf Aqueous Ethanolic Extract from Cotinus coggygria Scop.

    Directory of Open Access Journals (Sweden)

    Gospodinova Z.

    2017-10-01

    Full Text Available Cotinus coggygria Scop. leaf aqueous ethanolic extract was examined for its in vitro antiproliferative and antioxidant activity. Antiproliferative effect was assessed on four human gynecological cancer cell lines: breast (MCF7, T47D, cervical (HeLa and ovarian (A2780 and compared to the cell growth inhibitory effect on non-cancerous breast epithelial cell line MCF10A using MTT cell proliferation assay. Radical scavenging assay with DPPH was applied to evaluate antioxidant potential of the extract. The obtained results showed that the herb inhibited cell growth of all of the tested cancer cell lines and the highest was the cytostatic effect on A2780 cells with a half maximal inhibitory concentration (IC50 value of 30.8 μg/ml. For the other cell lines the IC50 values were in the range of 55-122.7 μg/ml. Additionally, the extract exerted considerably weaker reduction in cell proliferation of the non-cancerous cell line MCF10A compared to cancer cells, which indicates for antiproliferative selectivity. C. coggygria extract showed high free radical scavenging activity with an IC50 value of 11.2 μg/ml. The obtained data provide evidence for pharmacological potential of the tested extract and future more detailed studies concerning the molecular mechanisms of the anticancer effect of the herb are needed.

  8. Are uranium reserves adequate?

    International Nuclear Information System (INIS)

    Anon.

    2006-01-01

    Against a backdrop of growing concerns about global warming and geopolitical pressures on fossil energies, especially natural gas and oil, interest in nuclear power has revived considerably. Conscious of its addiction to oil and reeling from a series of gigantic blackouts, the United States, in the words of its president, must 'aggressively move forward with the construction of nuclear power plants'. Some European countries have approved new power plant construction (Finland and France), while the more reserved ones (Belgium, Germany and Sweden) have begun to show a change in attitude. Asia, meanwhile, is host to the planet's largest number of potential nuclear construction projects in this first half of the 21. century. All these signs point to a sharp rise in uranium consumption, the basic fuel for these plants. But are there enough resources to support a nuclear revival on a planetary scale? The publication of the Red Book on uranium in late May 2006 was an opportunity for Thierry Dujardin, Deputy Director of Science and Development at the OECD's Nuclear Energy Agency, to take stock of resources. He gives his opinion in this paper

  9. Computerized reserves assessment improves colliery planning. [Poland

    Energy Technology Data Exchange (ETDEWEB)

    Pozor, L.; Wrobel, R.

    1984-01-01

    The authors describe systems developed in Poland for the computerised assessment of coal reserves. The Zasoby system calculates coal reserves and evaluates selected natural properties of seams within the boundaries of an arbitrary mining property, based entirely on exploratory borehole data. The IOS-10 system is based on the Polish data bank for bituminous coal deposits. It is not suitable for use in mine design procedures, but is widely used for the statistical recording of reserves in areas currently being worked. The major part of the paper is devoted to a description of the Geo-3 system, used for the computation of reserves in prospective areas from borehole data, as well as in active mining areas or partially worked-out deposits. The computation method is explained and examples of the results obtained are given.

  10. 41 CFR 101-1.4901 - Standard forms. [Reserved

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Standard forms. [Reserved] 101-1.4901 Section 101-1.4901 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.49-Illustrations of Forms...

  11. The effect of surface modifications of carbon nanotubes on the electrical properties of inkjet-printed SWNT/PEDOT-PSS composite line patterns

    International Nuclear Information System (INIS)

    Najeeb, C K; Lee, Jae-Hyeok; Chang, Jingbo; Kim, Jae-Ho

    2010-01-01

    We prepared nanocomposite inks of poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT-PSS) filled with single-walled carbon nanotubes (SWNTs) purified by acidic treatment, carboxylated by chemical oxidation and carboxyl-functionalized nanotubes physically modified with a natural gum, gum arabic. Inkjet printing of line patterns with a feature size of 100 μm width and lengths ranging from 1 to 5 cm was performed on glass substrates with a piezoelectric inkjet printer. The carboxyl-functionalized SWNT-based composite demonstrated a significant decrease (fourfold) of electrical resistance for the line patterns compared to that with a purified CNT-based composite due to improved dispersability of nanotubes in the polymer matrix. The use of gum arabic for the dispersion of carboxyl-functionalized nanotubes demonstrated a further drastic decrease (18-fold) of the resistance compared with a purified CNT-based composite owing to the formation of an extended continuous network within the line pattern. The inkjet-printed conductive patterns can be applied in various fields, such as flexible high speed transistors, high efficiency solar cells and transparent electrodes.

  12. Bioenergetic and Antiapoptotic Properties of Mitochondria from Cultured Human Prostate Cancer Cell Lines PC-3, DU145 and LNCaP

    Science.gov (United States)

    Panov, Alexander; Orynbayeva, Zulfiya

    2013-01-01

    The purpose of this work was to reveal the metabolic features of mitochondria that might be essential for inhibition of apoptotic potential in prostate cancer cells. We studied mitochondria isolated from normal prostate epithelial cells (PrEC), metastatic prostate cancer cell lines LNCaP, PC-3, DU145; and non-prostate cancer cells - human fibrosarcoma HT1080 cells; and normal human lymphoblastoid cells. PrEC cells contained 2 to 4 times less mitochondria per gram of cells than the three PC cell lines. Respiratory activities of PrEC cell mitochondria were 5-20-fold lower than PC mitochondria, depending on substrates and the metabolic state, due to lower content and lower activity of the respiratory enzyme complexes. Mitochondria from the three metastatic prostate cancer cell lines revealed several features that are distinctive only to these cells: low affinity of Complex I for NADH, 20-30 mV higher electrical membrane potential (ΔΨ). Unprotected with cyclosporine A (CsA) the PC-3 mitochondria required 4 times more Ca2+ to open the permeability transition pore (mPTP) when compared with the PrEC mitochondria, and they did not undergo swelling even in the presence of alamethicin, a large pore forming antibiotic. In the presence of CsA, the PC-3 mitochondria did not open spontaneously the mPTP. We conclude that the low apoptotic potential of the metastatic PC cells may arise from inhibition of the Ca2+-dependent permeability transition due to a very high ΔΨ and higher capacity to sequester Ca2+. We suggest that due to the high ΔΨ, mitochondrial metabolism of the metastatic prostate cancer cells is predominantly based on utilization of glutamate and glutamine, which may promote development of cachexia. PMID:23951286

  13. Effect of Maillard reaction on biochemical properties of peanut 7S globulin (Ara h 1) and its interaction with a human colon cancer cell line (Caco-2)

    NARCIS (Netherlands)

    Teodorowicz, M.; Fiedorowicz, E.; Kostyra, H.; Wichers, H.J.; Kostyra, E.

    2013-01-01

    Purpose The purpose of this study was to determine the influence of Maillard reaction (MR, glycation) on biochemical and biological properties of the major peanut allergen Ara h 1. Methods Three different time/temperature conditions of treatment were applied (37, 60, and 145 °C). The extent of MR

  14. Virgo Cluster and field dwarf ellipticals in 3D: I. On the variety of stellar kinematic and line-strength properties

    OpenAIRE

    Ryś, Agnieszka; Falcón-Barroso, Jesús; van de Ven, Glenn

    2012-01-01

    We present the first large-scale stellar kinematic and line-strength maps for dwarf elliptical galaxies (9 in the Virgo Cluster and 3 in the field environment) obtained with the SAURON integral-field unit. No two galaxies in our sample are alike: we see that the level of rotation is not tied to flattening (we have, e.g. round rotators and flattened nonrotators); we observe kinematic twists in 1 Virgo and 1 field object; we discover large-scale kinematically-decoupled components in 2 field gal...

  15. 36 CFR 406.161-406.169 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false [Reserved] 406.161-406.169 Section 406.161-406.169 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION... BATTLE MONUMENTS COMMISSION §§ 406.161-406.169 [Reserved] ...

  16. 36 CFR 406.131-406.139 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false [Reserved] 406.131-406.139 Section 406.131-406.139 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION... BATTLE MONUMENTS COMMISSION §§ 406.131-406.139 [Reserved] ...

  17. 36 CFR 406.141-406.148 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false [Reserved] 406.141-406.148 Section 406.141-406.148 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION... BATTLE MONUMENTS COMMISSION §§ 406.141-406.148 [Reserved] ...

  18. 36 CFR 406.112-406.129 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false [Reserved] 406.112-406.129 Section 406.112-406.129 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION... BATTLE MONUMENTS COMMISSION §§ 406.112-406.129 [Reserved] ...

  19. 36 CFR 406.171-406.999 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false [Reserved] 406.171-406.999 Section 406.171-406.999 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION... BATTLE MONUMENTS COMMISSION §§ 406.171-406.999 [Reserved] ...

  20. 36 CFR 406.104-406.109 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false [Reserved] 406.104-406.109 Section 406.104-406.109 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION... BATTLE MONUMENTS COMMISSION §§ 406.104-406.109 [Reserved] ...

  1. 36 CFR 406.152-406.159 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false [Reserved] 406.152-406.159 Section 406.152-406.159 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION... BATTLE MONUMENTS COMMISSION §§ 406.152-406.159 [Reserved] ...

  2. production lines

    Directory of Open Access Journals (Sweden)

    Jingshan Li

    2000-01-01

    Full Text Available In this work, serial production lines with finished goods buffers operating in the pull regime are considered. The machines are assumed to obey Bernoulli reliability model. The problem of satisfying customers demand is addressed. The level of demand satisfaction is quantified by the due-time performance (DTP, which is defined as the probability to ship to the customer a required number of parts during a fixed time interval. Within this scenario, the definitions of DTP bottlenecks are introduced and a method for their identification is developed.

  3. Fractional Reserve in Banking System

    OpenAIRE

    Valkonen, Maria

    2016-01-01

    This thesis is aimed to provide understanding of the role of the fractional reserve in the mod-ern banking system worldwide and particularly in Finland. The fractional reserve banking is used worldwide, but the benefits of this system are very disputable. On the one hand, experts say that the fractional reserve is a necessary instrument for the normal business and profit making. On the other hand, sceptics openly criticize the fractional reserve system and blame it for fiat money (money n...

  4. Line facilities outline

    International Nuclear Information System (INIS)

    1998-08-01

    This book deals with line facilities. The contents of this book are outline line of wire telecommunication ; development of line, classification of section of line and theory of transmission of line, cable line ; structure of line, line of cable in town, line out of town, domestic cable and other lines, Optical communication ; line of optical cable, transmission method, measurement of optical communication and cable of the sea bottom, Equipment of telecommunication line ; telecommunication line facilities and telecommunication of public works, construction of cable line and maintenance and Regulation of line equipment ; regulation on technique, construction and maintenance.

  5. Effect of exopolysaccharide from Ganoderma applanatum on the electrical properties of mouse fibroblast cells line L929 culture using an electric cell-substrate impedance sensing (ECIS) - Preliminary study.

    Science.gov (United States)

    Prendecka, Monika; Mlak, Radosław; Jaszek, Magdalena; Osińska-Jaroszuk, Monika; Jakubiak-Hulicz, Monika; Leibold, Christian; Bieser, Armin; Wójcik, Waldemar; Małecka-Massalska, Teresa

    2016-06-02

    IIntroduction and objective. In recent years there has been intensified research on medicinal preparations of fungal origin. Some fungal polysaccharides may directly affect the inhibition of cancer cells proliferation which, stopping the cell cycle, leads to apoptosis. One of these substances (component of extract of Ganoderma spp) is extensively tested for its anti-cancer properties on the tumor cell lines. Electric cell-substrate impedance sensing (ECIS) is an in vitro impedance measuring system using alternating current (AC) to determinate the behaviour of the cells in physiological conditions. The aim of the study was to examine the electric properties (resistance, capacitance and impedance) of mouse fibroblasts cell line L929 after treatment by different concentration of crude exopolysaccharides from Ganoderma applanatum (GpEPS) in real time by ECIS technique. For the study, the L929 cell line culture was treated by different concentrations of GpEPS: C1=228.5 µg/mL; C2=22.85 µg/mL; C3=2.285 µg/mL; C4=0.2285 µg/mL; and C5=0.02285 µg/mL. Default optimal frequencies were used: Resistance (R) 4000Hz, Impedance (Z) 16000Hz, Capacitance (C) 64000Hz. The study demonstrated that GpEPS had no significant effect on the resistance, capacitance and impedance cells cultures, which implies that there is no significant effect on the physiological processes of L929 fibroblasts. This indicates the possibility of using GpEPS preparation in anti-cancer therapy. In the future, following further studies (comprising in preventive and therapeutic actions), GpEPS can be safely used in anti-cancer therapy which does not cause side-effects or damage to healthy cells.

  6. Parallel Lines

    Directory of Open Access Journals (Sweden)

    James G. Worner

    2017-05-01

    Full Text Available James Worner is an Australian-based writer and scholar currently pursuing a PhD at the University of Technology Sydney. His research seeks to expose masculinities lost in the shadow of Australia’s Anzac hegemony while exploring new opportunities for contemporary historiography. He is the recipient of the Doctoral Scholarship in Historical Consciousness at the university’s Australian Centre of Public History and will be hosted by the University of Bologna during 2017 on a doctoral research writing scholarship.   ‘Parallel Lines’ is one of a collection of stories, The Shapes of Us, exploring liminal spaces of modern life: class, gender, sexuality, race, religion and education. It looks at lives, like lines, that do not meet but which travel in proximity, simultaneously attracted and repelled. James’ short stories have been published in various journals and anthologies.

  7. 32 CFR 644.7 - Acquisition lines.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Acquisition lines. 644.7 Section 644.7 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Project Planning Civil Works § 644.7 Acquisition lines. (a) Tentative acquisition lines. As...

  8. Cytotoxic Effect on MG-63 Cell Line and Antimicrobial and Antioxidant Properties of Silver Nanoparticles Synthesized with Seed Extracts of Capsicum sp.

    Directory of Open Access Journals (Sweden)

    Nidhi Singh

    2016-01-01

    Full Text Available Applying the concept of ethnobotany, plant extract was taken into consideration as an alternative to chemicals synthesis of silver nanoparticle. The extracts from the chilli seeds were used to synthesize silver nanoparticles (AgNPs. In this study two species of chilli, Capsicum annuum and Capsicum frutescens, have been used to analyse the characteristics of the bio-active compounds found in their seeds. Analysis of the bioactive compound was performed by using Soxhlet extraction with solvents followed by Thin Layer Chromatography (TLC, High Performance Liquid Chromatography (HPLC and GC-MS. Furthermore, green synthesis of nanoparticles with chilli extracts was carried out using silver nitrate to detect its antimicrobial activity. The characterizations of both the nanoparticles were carried out using UV-Vis Spectroscopy, Atomic Force Microscopy (AFM, Fourier Transform Infrared Spectroscopy (FTIR, X-Ray Diffractometry (XRD, Scanning Electron Microscopy (SEM and energy Dispersive X-Ray Spectroscopy (EDX. Antimicrobial activity against clinical pathogens and the antioxidant assay using DPPH and FRAP assays were performed. The cytotoxicity effects on osteosarcoma cell lines were also evaluated with the synthesized AgNPs.

  9. Glutathione Fine-Tunes the Innate Immune Response toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties.

    Science.gov (United States)

    Diotallevi, Marina; Checconi, Paola; Palamara, Anna Teresa; Celestino, Ignacio; Coppo, Lucia; Holmgren, Arne; Abbas, Kahina; Peyrot, Fabienne; Mengozzi, Manuela; Ghezzi, Pietro

    2017-01-01

    Glutathione (GSH), a major cellular antioxidant, is considered an inhibitor of the inflammatory response involving reactive oxygen species (ROS). However, evidence is largely based on experiments with exogenously added antioxidants/reducing agents or pro-oxidants. We show that depleting macrophages of 99% of GSH does not exacerbate the inflammatory gene expression profile in the RAW264 macrophage cell line or increase expression of inflammatory cytokines in response to the toll-like receptor 4 (TLR4) agonist lipopolysaccharide (LPS); only two small patterns of LPS-induced genes were sensitive to GSH depletion. One group, mapping to innate immunity and antiviral responses (Oas2, Oas3, Mx2, Irf7, Irf9, STAT1, il1b), required GSH for optimal induction. Consequently, GSH depletion prevented the LPS-induced activation of antiviral response and its inhibition of influenza virus infection. LPS induction of a second group of genes (Prdx1, Srxn1, Hmox1, GSH synthase, cysteine transporters), mapping to nrf2 and the oxidative stress response, was increased by GSH depletion. We conclude that the main function of endogenous GSH is not to limit inflammation but to fine-tune the innate immune response to infection.

  10. Biosphere reserves: Attributes for success.

    Science.gov (United States)

    Van Cuong, Chu; Dart, Peter; Hockings, Marc

    2017-03-01

    Biosphere reserves established under the UNESCO Man and the Biosphere Program aim to harmonise biodiversity conservation and sustainable development. Concerns over the extent to which the reserve network was living up to this ideal led to the development of a new strategy in 1995 (the Seville Strategy) to enhance the operation of the network of reserves. An evaluation of effectiveness of management of the biosphere reserve network was called for as part of this strategy. Expert opinion was assembled through a Delphi Process to identify successful and less successful reserves and investigate common factors influencing success or failure. Ninety biosphere reserves including sixty successful and thirty less successful reserves in 42 countries across all five Man and the Biosphere Program regions were identified. Most successful sites are the post-Seville generation while the majority of unsuccessful sites are pre-Seville that are managed as national parks and have not been amended to conform to the characteristics that are meant to define a biosphere reserve. Stakeholder participation and collaboration, governance, finance and resources, management, and awareness and communication are the most influential factors in the success or failure of the biosphere reserves. For success, the biosphere reserve concept needs to be clearly understood and applied through landscape zoning. Designated reserves then need a management system with inclusive good governance, strong participation and collaboration, adequate finance and human resource allocation and stable and responsible management and implementation. All rather obvious but it is difficult to achieve without commitment to the biosphere reserve concept by the governance authorities. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Nuclear, uranium, reserves, sustainability, independence; Nucleaire, Uranium, reserves, durabilite, independance

    Energy Technology Data Exchange (ETDEWEB)

    Acket, C

    2007-06-15

    In order to evaluate the energy independence concerning the nuclear energy, the author takes the state of the art about the uranium. He details the fuel needs, the reserves on the base of the today available techniques, the reserves on the base of the future techniques and concludes positively on the energy independence for the nuclear. (A.L.B.)

  12. Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE1-Muta(TM) mouse lung epithelial cell line.

    Science.gov (United States)

    Jackson, Petra; Kling, Kirsten; Jensen, Keld Alstrup; Clausen, Per Axel; Madsen, Anne Mette; Wallin, Håkan; Vogel, Ulla

    2015-03-01

    Carbon nanotubes vary greatly in physicochemical properties. We compared cytotoxic and genotoxic response to 15 multiwalled carbon nanotubes (MWCNT) with varying physicochemical properties to identify drivers of toxic responses. The studied MWCNT included OECD Working Party on Manufactured Nanomaterials (WPMN) (NM-401, NM-402, and NM-403), materials (NRCWE-026 and MWCNT-XNRI-7), and three sets of surface-modified MWCNT grouped by physical characteristics (thin, thick, and short I-III, respectively). Each Groups I-III included pristine, hydroxylated and carboxylated MWCNT. Group III also included an amino-functionalized MWCNT. The level of surface functionalization of the MWCNT was low. The level and type of elemental impurities of the MWCNT varied by <2% of the weight, with exceptions. Based on dynamic light scattering data, the MWCNT were well-dispersed in stock dispersion of nanopure water with 2% serum, but agglomerated and sedimented during exposure. FE1-Muta(TM) Mouse lung epithelial cells were exposed for 24 hr. The levels of DNA strand breaks (SB) were evaluated using the comet assay, a screening assay suitable for genotoxicity testing of nanomaterials. Exposure to MWCNT (12.5-200 µg/ml) did not induce significant cytotoxicity (viability above 92%). Cell proliferation was reduced in highest doses of some MWCNT after 24 hr, and was associated with generation of reactive oxygen species and high surface area. Increased levels of DNA SB were only observed for Group II consisting of MWCNT with large diameters and high Fe2 O3 and Ni content. Significantly, increased levels of SB were only observed at 200 µg/ml of MWCNT-042. Overall, the MWCNT were not cytotoxic and weakly genotoxic after 24 hr exposure to doses up to 200 µg/ml. © 2014 Wiley Periodicals, Inc.

  13. Similarity law for Widom lines and coexistence lines.

    Science.gov (United States)

    Banuti, D T; Raju, M; Ihme, M

    2017-05-01

    The coexistence line of a fluid separates liquid and gaseous states at subcritical pressures, ending at the critical point. Only recently, it became clear that the supercritical state space can likewise be divided into regions with liquidlike and gaslike properties, separated by an extension to the coexistence line. This crossover line is commonly referred to as the Widom line, and is characterized by large changes in density or enthalpy, manifesting as maxima in the thermodynamic response functions. Thus, a reliable representation of the coexistence line and the Widom line is important for sub- and supercritical applications that depend on an accurate prediction of fluid properties. While it is known for subcritical pressures that nondimensionalization with the respective species critical pressures p_{cr} and temperatures T_{cr} only collapses coexistence line data for simple fluids, this approach is used for Widom lines of all fluids. However, we show here that the Widom line does not adhere to the corresponding states principle, but instead to the extended corresponding states principle. We resolve this problem in two steps. First, we propose a Widom line functional based on the Clapeyron equation and derive an analytical, species specific expression for the only parameter from the Soave-Redlich-Kwong equation of state. This parameter is a function of the acentric factor ω and compares well with experimental data. Second, we introduce the scaled reduced pressure p_{r}^{*} to replace the previously used reduced pressure p_{r}=p/p_{cr}. We show that p_{r}^{*} is a function of the acentric factor only and can thus be readily determined from fluid property tables. It collapses both subcritical coexistence line and supercritical Widom line data over a wide range of species with acentric factors ranging from -0.38 (helium) to 0.34 (water), including alkanes up to n-hexane. By using p_{r}^{*}, the extended corresponding states principle can be applied within

  14. Thermal Effect on the Structural, Electrical, and Optical Properties of In-Line Sputtered Aluminum Doped Zinc Oxide Films Explored with Thermal Desorption Spectroscopy

    Directory of Open Access Journals (Sweden)

    Shang-Chou Chang

    2014-01-01

    Full Text Available This work investigates the thermal effect on the structural, electrical, and optical properties of aluminum doped zinc oxide (AZO films. The AZO films deposited at different temperatures were measured using a thermal desorption system to obtain their corresponding thermal desorption spectroscopy (TDS. In addition to obtaining information of thermal desorption, the measurement of TDS also has the effect of vacuum annealing on the AZO films. The results of measuring TDS imply part of the doped aluminum atoms do not stay at substituted zinc sites in AZO films. The (002 preferential direction of the AZO films in X-ray diffraction spectra shifts to a lower angle after measurement of TDS. The grain size grows and surface becomes denser for all AZO films after measurement of TDS. The carrier concentration, mobility, and average optical transmittance increase while the electrical resistivity decreases for AZO films after measurement of TDS. These results indicate that the AZO films deposited at 200°C are appropriate selections if the AZO films are applied in device fabrication of heat-produced process.

  15. Youth Problems on Indian Reservations.

    Science.gov (United States)

    Underhill, Ruth M., Ed.

    Juvenile delinquency was identified as the major problem affecting youth on Indian reservations. Causes for delinquency which were discussed included culture conflict, expectation of failure, unemployment, failure of homes and parents, discrimination, inadequate education, off-reservation schools, and alcoholism. Needs identified by tribal leaders…

  16. Can Creativity Predict Cognitive Reserve?

    Science.gov (United States)

    Palmiero, Massimiliano; Di Giacomo, Dina; Passafiume, Domenico

    2016-01-01

    Cognitive reserve relies on the ability to effectively cope with aging and brain damage by using alternate processes to approach tasks when standard approaches are no longer available. In this study, the issue if creativity can predict cognitive reserve has been explored. Forty participants (mean age: 61 years) filled out: the Cognitive Reserve…

  17. Deep Percolation in Arid Piedmont Slopes: Multiple Lines of Evidence Show How Land Use Change and Ecohydrological Properties Affect Groundwater Recharge

    Science.gov (United States)

    Schreiner-McGraw, A.; Vivoni, E. R.; Browning, D. M.

    2017-12-01

    A critical hydrologic process in arid regions is the contribution of episodic streamflow in ephemeral channels to groundwater recharge. This process has traditionally been studied in channels that drain large watersheds (10s to 100s km2). In this study, we aim to characterize the provision of the ecosystem services of surface and groundwater supply in a first-order watershed (4.6 ha) in an arid piedmont slope of the Jornada Experimental Range (JER). We use an observational and modeling approach to estimate deep percolation. During a 6 year study period, we observed 428 mm of percolation (P) and 39 mm of runoff (Q); ratios of P to rainfall (R) of P/R = 0.27 and Q/R = 0.02. Utilizing an instrument network and site measurements, we determine that percolation occurs primarily inside channel reaches when these receive runoff from upland hillslopes and find that a monthly rainfall threshold of 62 mm is needed for significant percolation to be generated. In order to quantify the mechanisms leading to this threshold response, we develop a channel transmission loss module for the TIN-based Real-time Integrated Basin Simulator (tRIBS) and test the model thoroughly against the available observations over the study period. For these purposes, we make use of image classifications from Unmanned Aerial Vehicle flights, a ground-based phenocam, and species-level measurements to parameterize vegetation processes in the model. We then conduct an extensive set of sensitivity experiments to determine the relative roles of channel, soil, and vegetation properties on modifying the relation between monthly rainfall and percolation. Additionally, we test how the observed vegetation transitions in the JER over the last 150 years affect the deep percolation and runoff estimates. By quantifying mechanisms through which vegetation changes affect water resource provision, this work provides new insights on the ecohydrological controls on the water yield of arid piedmont slopes.

  18. OMEGA - OSIRIS Mapping of Emission-line Galaxies in A901/2 - III. Galaxy properties across projected phase space in A901/2

    Science.gov (United States)

    Weinzirl, Tim; Aragón-Salamanca, Alfonso; Gray, Meghan E.; Bamford, Steven P.; Rodríguez del Pino, Bruno; Chies-Santos, Ana L.; Böhm, Asmus; Wolf, Christian; Cool, Richard J.

    2017-10-01

    We conduct a comprehensive projected phase-space analysis of the A901/2 multicluster system at z ˜ 0.165. Aggregating redshifts from spectroscopy, tunable-filter imaging and prism techniques, we assemble a sample of 856 cluster galaxies reaching 108.5 M⊙ in stellar mass. We look for variations in cluster galaxy properties between virialized and non-virialized regions of projected phase space (PPS). Our main conclusions point to relatively gentle environmental effects, expressed mainly on galaxy gas reservoirs. (1) Stacking the four subclusters in A901/2, we find galaxies in the virialized region are more massive, redder and have marginally higher Sérsic indices, but their half-light radii and Hubble types are not significantly different. (2) After accounting for trends in stellar mass, there is a remaining change in rest-frame colour across PPS. Primarily, the colour difference is due to the absence in the virialized region of galaxies with rest frame B - V 109.85 M⊙) stellar mass. (3) There is an infalling population of lower mass (M⋆ ≤ 109.85 M⊙), relatively blue (B - V PPS regions is strongly dictated by stellar mass. However, there remains a reduced fraction of star-forming galaxies in the centres of the clusters at fixed stellar mass, consistent with the star formation-density relation in galaxy clusters. (5) There is no change in specific Hα-derived star formation rates of star-forming galaxies at fixed mass across the cluster environment. This suggests that pre-processing of galaxies during infall plays a prominent role in quenching star formation.

  19. Properties of QSO Metal-line Absorption Systems at High Redshifts: Nature and Evolution of the Absorbers and New Evidence on Escape of Ionizing Radiation from Galaxies

    Science.gov (United States)

    Boksenberg, Alec; Sargent, Wallace L. W.

    2015-05-01

    Using Voigt-profile-fitting procedures on Keck High Resolution Spectrograph spectra of nine QSOs, we identify 1099 C IV absorber components clumped in 201 systems outside the Lyman forest over 1.6 associated Si IV, C II, Si II and N V where available, we investigate the bulk statistical and ionization properties of the components and systems and find no significant change in redshift for C IV and Si IV while C II, Si II and N V change substantially. The C IV components exhibit strong clustering, but no clustering is detected for systems on scales from 150 km s-1 out to 50,000 km s-1. We conclude that the clustering is due entirely to the peculiar velocities of gas present in the circumgalactic media of galaxies. Using specific combinations of ionic ratios, we compare our observations with model ionization predictions for absorbers exposed to the metagalactic ionizing radiation background augmented by proximity radiation from their associated galaxies and find that the generally accepted means of radiative escape by transparent channels from the internal star-forming sites is spectrally not viable for our stronger absorbers. We develop an active scenario based on runaway stars with resulting changes in the efflux of radiation that naturally enable the needed spectral convergence, and in turn provide empirical indicators of morphological evolution in the associated galaxies. Together with a coexisting population of relatively compact galaxies indicated by the weaker absorbers in our sample, the collective escape of radiation is sufficient to maintain the intergalactic medium ionized over the full range 1.9 National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation.

  20. CIRCULATING INTER-OPERATIONAL RESERVES: LONG-TIME ERRORS

    Directory of Open Access Journals (Sweden)

    G. A. Каlinkin

    2009-01-01

    Full Text Available The paper shows that for dozens of years some researchers have presented a formula for calculating changes in circulating inter-operational reserve in the working phase of the flow production line in a wrong way as a formula for calculating a maximum change in the circulating inter-operational reserve of the working phase and the paper proposes an algorithm for calculation of circulating reserve in a boundary point of working phases of straight flow line. Having calculated a maximum change of the circulating reserve in the working phases it is possible to obtain an algebraic sum of reserve changes . After that the total algebraic sum of circulating reserve changes in boundary points from the initial phase to the final one. According to a minimum value of the algebraic sum of  the reserve changes in the phases it is possible to find a boundary point of phases where the reserve is equal to zero. A reserve in any boundary point  of  phases  is  calculated  through  finding  an  absolute value of the algebraic sum of reserve changes from boundary point of phases, where the reserve is equal to zero, to the sought one.

  1. [Expression and properties of potassium channels in human mammary epithelial cell line MCF10A and its possible role in proliferation].

    Science.gov (United States)

    Liu, Jia; Feng, Shuang; Zhang, Lei; Wu, Zheng; Chen, Qian; Cheng, Wei; Wang, Shi-Qiang; Zou, Wei

    2010-06-25

    Voltage-dependent potassium channels (Kv) are involved in proliferation and transformation in mammary epithelial cells. In previous studies, several groups have detected various potassium channels in breast cancer cells, and they assumed that potassium channels are related to the development of breast carcinoma, although the precise mechanisms are still unknown. We have previously reported that 4-aminopyridine (4-AP), one kind of potassium channel (K(+) channel) blocker, could affect the proliferation of MCF10A cells. The aim of the present study is to explore the expression and properties of K(+) channels in human mammary epithelial cells (MCF10A) and whether Kv channels are required for the proliferation of MCF10A cell. Electrophysiological, MTT analysis, PCR and Western blot methods were used to identify a K(+) conductance which is involved in tumorigenesis and not yet be described in MCF10A cells. A voltage-dependent, outward rectification and 4-AP-sensitive K(+) current was observed in these cells. The perfusion of 5 mmol/L 4-AP significantly decreased the amplitude of Kv current from (912.5+/-0.6) pA to (275+/-0.8) pA (n=5, PMCF10A and MCF7 cells. Furthermore, the expression of Kv1.5 was much higher in MCF10A than that in MCF7. Inhibitory effect of 4-AP on cell proliferation was dosage-dependent. Incubation with 5 mmol/L 4-AP reduced MCF10A cell proliferation to 25.29% in 48 h. Western blot analysis showed the activation of ERK1/2 which related to cell proliferation was enhanced, while p38 activation was decreased by 4-AP treatment for 10 min. These data provided the first evidence of the Kv channels expression in MCF10A cell and 4-AP could inhibit the proliferation of MCF10A through blocking the potassium channels, and the mechanism may be related to regulating the activity of different members of cell proliferation signaling pathway of MEK/ERK.

  2. Estimating Foreign Exchange Reserve Adequacy

    Directory of Open Access Journals (Sweden)

    Abdul Hakim

    2013-04-01

    Full Text Available Accumulating foreign exchange reserves, despite their cost and their impacts on other macroeconomics variables, provides some benefits. This paper models such foreign exchange reserves. To measure the adequacy of foreign exchange reserves for import, it uses total reserves-to-import ratio (TRM. The chosen independent variables are gross domestic product growth, exchange rates, opportunity cost, and a dummy variable separating the pre and post 1997 Asian financial crisis. To estimate the risky TRM value, this paper uses conditional Value-at-Risk (VaR, with the help of Glosten-Jagannathan-Runkle (GJR model to estimate the conditional volatility. The results suggest that all independent variables significantly influence TRM. They also suggest that the short and long run volatilities are evident, with the additional evidence of asymmetric effects of negative and positive past shocks. The VaR, which are calculated assuming both normal and t distributions, provide similar results, namely violations in 2005 and 2008.

  3. Cognitive Reserve Scale and ageing

    Directory of Open Access Journals (Sweden)

    Irene León

    2016-01-01

    Full Text Available The construct of cognitive reserve attempts to explain why some individuals with brain impairment, and some people during normal ageing, can solve cognitive tasks better than expected. This study aimed to estimate cognitive reserve in a healthy sample of people aged 65 years and over, with special attention to its influence on cognitive performance. For this purpose, it used the Cognitive Reserve Scale (CRS and a neuropsychological battery that included tests of attention and memory. The results revealed that women obtained higher total CRS raw scores than men. Moreover, the CRS predicted the learning curve, short-term and long-term memory, but not attentional and working memory performance. Thus, the CRS offers a new proxy of cognitive reserve based on cognitively stimulating activities performed by healthy elderly people. Following an active lifestyle throughout life was associated with better intellectual performance and positive effects on relevant aspects of quality of life.

  4. Fractional Reserve Banking: Some Quibbles

    OpenAIRE

    Bagus, Philipp; Howden, David

    2010-01-01

    We explore several unaddressed issues in George Selgin’s (1988) claim that the best monetary system to maintain monetary equilibrium is a fractional reserve free banking one. The claim that adverse clearing balances would limit credit expansion in a fractional reserve free banking system is more troublesome than previously reckoned. Both lengthened clearing periods and interbank agreements render credit expansion unrestrained. “The theory of free banking” confuses increases in money held with...

  5. Pentagon Reservation Maintenance Revolving Fund

    National Research Council Canada - National Science Library

    2001-01-01

    .... Consequently, the DoD must accurately report property, plant, and equipment in order for the Government to achieve a favorable opinion on the consolidated financial statements of both the DoD and the Federal Government...

  6. Reserve Retirement Equality: Treating Reserves Fairly While Saving Taxpayer Dollars

    Science.gov (United States)

    2010-06-09

    rata .121 For example, a Reserve who performs the equivalent of five years of active duty, will receive one-fourth the retired pay of his active duty...4,225 per month.124 But because reserve-retirement benefits are based on pro rata years of service, this officer’s years of service for retirement...purposes are 3,146 retirement points divided by 360.125 This results in 8.74 years pro rata years of service.126 His retirement benefits thus are

  7. Demand as frequency controlled reserve

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Z.; Togeby, M.; OEstergaard, J.

    2008-09-15

    Using demand as frequency controlled reserve (DFR) is an emerging technology which allow demand to participate actively in maintaining the system operation without reducing the energy service delivered to the customer and without need of user interaction. The basic premise is that traditional frequency controlled reserves from power plants and interconnections with neighbouring systems can be costly, slow and not fulfil the need for future power grids with a high share of wind power and fewer central power plants, and an intention to perform flexible operation such as is landing. Electricity demands, on the other hand, have advantages as frequency reserve including fast activation speed, smooth linear activation, low expected costs, and well-dispersed in the distribution grid. The main challenge of DFR is new methods for monitoring the available capacity. This project has investigated the technology of using electricity demands for providing frequency reserve to power systems. Within the project the potential and economy of DFR compatible loads in Denmark has been investigated, control logic has been designed, power system impact has been investigated, potential business models has been evaluated and an implementation strategy has been suggested. The tasks and goals of the project have been successfully accomplished based on which the conclusion and future recommendation are made. This project has developed the DFR technology that enables electricity demands to autonomously disconnect or reconnect to the grid in response to system frequency variations. The developed DFR technology is proved to be a promising technology from several perspectives. Technically, using DFR is feasible to provide reserves and enhance power system frequency control, while fulfilling technical requirements such as linear activation (or reconnection) according to frequency (or time). Environmentally, the DFR technology is pollution free in contrast to traditional reserves from generation

  8. Improved Effectiveness of Reserve Forces During Reserve Duty Training.

    Science.gov (United States)

    Treadaway, Harry H.

    The problem areas of motivation, job enrichment, recruiting, and retention are addressed from the viewpoint of the behavioral scientist. Special attention is given to relating job enrichment and motivation techniques, as successfully demonstrated in industry, to the United State Army Reserve. Research method utilized was a literature review…

  9. Spinning Reserve From Responsive Loads

    Energy Technology Data Exchange (ETDEWEB)

    Kirby, B.J.

    2003-04-08

    Responsive load is the most underutilized reliability resource available to the power system today. It is currently not used at all to provide spinning reserve. Historically there were good reasons for this, but recent technological advances in communications and controls have provided new capabilities and eliminated many of the old obstacles. North American Electric Reliability Council (NERC), Federal Energy Regulatory Commission (FERC), Northeast Power Coordinating Council (NPCC), New York State Reliability Council (NYSRC), and New York Independent System Operator (NYISO) rules are beginning to recognize these changes and are starting to encourage responsive load provision of reliability services. The Carrier ComfortChoice responsive thermostats provide an example of these technological advances. This is a technology aimed at reducing summer peak demand through central control of residential and small commercial air-conditioning loads. It is being utilized by Long Island Power Authority (LIPA), Consolidated Edison (ConEd), Southern California Edison (SCE), and San Diego Gas and Electric (SDG&E). The technology is capable of delivering even greater response in the faster spinning reserve time frame (while still providing peak reduction). Analysis of demand reduction testing results from LIPA during the summer of 2002 provides evidence to back up this claim. It also demonstrates that loads are different from generators and that the conventional wisdom, which advocates for starting with large loads as better ancillary service providers, is flawed. The tempting approach of incrementally adapting ancillary service requirements, which were established when generators were the only available resources, will not work. While it is easier for most generators to provide replacement power and non-spinning reserve (the slower response services) than it is to supply spinning reserve (the fastest service), the opposite is true for many loads. Also, there is more financial

  10. Line bundles and flat connections

    Indian Academy of Sciences (India)

    We prove that there are cocompact lattices Γ in S L ( 2 , C ) with the property that there are holomorphic line bundles L on S L ( 2 , C ) / Γ with c 1 ( L ) = 0 such that L does not admit any unitary flat connection. Author Affiliations. INDRANIL BISWAS1 GEORG SCHUMACHER2. School of Mathematics, Tata Institute of ...

  11. Cerebral correlates of cognitive reserve.

    Science.gov (United States)

    Whalley, Lawrence J; Staff, Roger T; Fox, Helen C; Murray, Alison D

    2016-01-30

    Cognitive reserve is a hypothetical concept introduced to explain discrepancies between severity of clinical dementia syndromes and the extent of dementia pathology. We examined cognitive reserve in a research programme that followed up a non-clinical sample born in 1921 or 1936 and IQ-tested age 11 years in 1932 or 1947. Structural MRI exams were acquired in about 50% of the sample from whom a subsample were recruited into an additional fMRI study. Here, we summarise findings from seven inter-related studies. These support an understanding of cognitive reserve as a balance between positive life course activity-driven experiences and the negative effects of brain pathologies including cerebrovascular disease and total and regional brain volume loss. Hypothesised structural equation models illustrate the relative causal effects of these positive and negative contributions. Cognitive reserve is considered in the context of choice of interventions to prevent dementia and the opposing effects of cerebrovascular disease and Alzheimer like brain appearances. Crown Copyright © 2015. Published by Elsevier Ireland Ltd. All rights reserved.

  12. Extractive reserves in Brazilian Amazonia

    Energy Technology Data Exchange (ETDEWEB)

    Fearnside, P.M (National Institute for Research in the Amazon, Manaus-Amazonas (Brazil))

    1989-06-01

    In 1985 an opportunity arose for maintaining tracts of Amazonian forest under sustainable use. Brazil's National Council of Rubber Tappers and the Rural Worker's Union proposed the creation of a set of reserves of a new type, called extractive reserves. The first six are being established in one of the Brazilian states most threatened by deforestatation. The creation of extractive reserves grants legal protection to forest land traditionally used by rubber tappers, Brazil-nut gatherers, and other extractivists. The term extrativismo (extractivism) in Brazil refers to removing nontimber forest products, such as latex, resins, and nuts, without felling the trees. Approximately 30 products are collected for commercial sale. Many more types of forest materials are gathered, for example as food and medicines, for the extractivists' own use. The reserve proposal is attractive for several reasons related to social problems. It allows the rubber tappers to continue their livelihood rather than be expelled by deforestation. However, it is unlikely that sufficient land will be set aside as extractive reserves to employ all the tappers. Displaced rubber tappers already swell the ranks of urban slum dwellers in Brazil's Amazonian cities, and they have become refugees to continue their profession in the forests of neighboring countries, such as Bolivia.

  13. Spent Pot Lining Characterization Framework

    Science.gov (United States)

    Ospina, Gustavo; Hassan, Mohamed I.

    2017-09-01

    Spent pot lining (SPL) management represents a major concern for aluminum smelters. There are two key elements for spent pot lining management: recycling and safe storage. Spent pot lining waste can potentially have beneficial uses in co-firing in cement plants. Also, safe storage of SPL is of utmost importance. Gas generation of SPL reaction with water and ignition sensitivity must be studied. However, determining the feasibility of SPL co-firing and developing the required procedures for safe storage rely on determining experimentally all the necessary SPL properties along with the appropriate test methods, recognized by emissions standards and fire safety design codes. The applicable regulations and relevant SPL properties for this purpose are presented along with the corresponding test methods.

  14. Hydrocarbon Reserves: Abundance or Scarcity

    International Nuclear Information System (INIS)

    2005-01-01

    IFP and the OAPEC jointly organize a regular international seminar dealing with world oil-related problems appearing in the news. For the first time, this seminar has been opened to oil and gas company specialists, service companies, research centers and independents. This year's theme concerns oil and gas reserves: are they abundant or are we headed towards the shortages announced by some experts? This theme is especially topical in that: oil and gas currently meet two thirds of world energy needs and almost completely dominate the transport sector; the reserves declared by the OAPEC countries account for nearly half of world reserves; the price of a barrel of oil went through the roof in 2004; world energy demand is growing fast and alternative sources of energy are far from ready to take over from oil and gas in the next few decades. Since the reserves correspond to the volume it is technically and economically viable to produce, the seminar has, of course, dealt with the technical and economic questions that arise in connection with exploration and production, but it has also considered changes in the geopolitical context. Presentations by the leading companies of the OAPEC countries and by the IFP group were completed by presentation from the International Energy Agency (IEA), the United States Geological Survey (USGS), the IHS Energy Group, Total and Gaz de France. This document gathers the transparencies of the following presentations: Hydrocarbon reserves in OAPEC members countries: current and future (M. Al-Lababidi); Non OAPEC liquid reserves and production forecasts (Y. Mathieu); World oil and gas resources and production outlook (K. Chew); Global investments in the upstream (F. Birol); Total's policy in the oil and gas sector (C. de Margerie); Gaz de France's policy in the oil and gas sector (J. Abiteboul); NOC/IOC's opportunities in OPEC countries (I. Sandrea); Relationships between companies, countries and investors: How they may impact on the growth

  15. Hydrocarbon Reserves: Abundance or Scarcity

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    IFP and the OAPEC jointly organize a regular international seminar dealing with world oil-related problems appearing in the news. For the first time, this seminar has been opened to oil and gas company specialists, service companies, research centers and independents. This year's theme concerns oil and gas reserves: are they abundant or are we headed towards the shortages announced by some experts? This theme is especially topical in that: oil and gas currently meet two thirds of world energy needs and almost completely dominate the transport sector; the reserves declared by the OAPEC countries account for nearly half of world reserves; the price of a barrel of oil went through the roof in 2004; world energy demand is growing fast and alternative sources of energy are far from ready to take over from oil and gas in the next few decades. Since the reserves correspond to the volume it is technically and economically viable to produce, the seminar has, of course, dealt with the technical and economic questions that arise in connection with exploration and production, but it has also considered changes in the geopolitical context. Presentations by the leading companies of the OAPEC countries and by the IFP group were completed by presentation from the International Energy Agency (IEA), the United States Geological Survey (USGS), the IHS Energy Group, Total and Gaz de France. This document gathers the transparencies of the following presentations: Hydrocarbon reserves in OAPEC members countries: current and future (M. Al-Lababidi); Non OAPEC liquid reserves and production forecasts (Y. Mathieu); World oil and gas resources and production outlook (K. Chew); Global investments in the upstream (F. Birol); Total's policy in the oil and gas sector (C. de Margerie); Gaz de France's policy in the oil and gas sector (J. Abiteboul); NOC/IOC's opportunities in OPEC countries (I. Sandrea); Relationships between companies, countries and investors: How they may

  16. Demand as Frequency Controlled Reserve

    DEFF Research Database (Denmark)

    Xu, Zhao; Østergaard, Jacob; Togeby, Mikael

    2011-01-01

    Relying on generation side alone is deemed insufficient to fulfill the system balancing needs for future Danish power system, where a 50% wind penetration is outlined by the government for year 2025. This paper investigates using the electricity demand as frequency controlled reserve (DFR) as a new...... balancing measure, which has a high potential and can provide many advantages. Firstly, the background of the research is reviewed, including conventional power system reserves and the electricity demand side potentials. Subsequently, the control logics and corresponding design considerations for the DFR...

  17. 77 FR 40253 - Reserve Account

    Science.gov (United States)

    2012-07-09

    .... The commentators represented Rural Development employees who work with the Multi-Family Housing Direct... their annual over-inflated tax bills and assessments. As a result, rent income funding that could be..., as rents cannot be raised to an amount that will cover all current and future reserve expenses...

  18. Demand as Frequency Controlled Reserve

    DEFF Research Database (Denmark)

    Xu, Zhao; Togeby, Mikael; Østergaard, Jacob

    This report summaries the research outcomes of the project ‘Demand as Frequency Controlled Reserve (DFR)’, which has received the support from Energinet.dk’s PSO program, Grant no. 2005-2-6380. The objective of this project is to investigate the technology of using electricity demands for providing...

  19. 75 FR 49887 - National Estuarine Research Reserve System

    Science.gov (United States)

    2010-08-16

    ... marsh, cobble beaches, and both hard and soft substrate submerged lands. The island is considered a... salt marsh habitat. The 128 acre Ballard Property on Prudence Island consists of forested land with... the reserve; and the plans for future land acquisition and facility development to support reserve...

  20. Effects of different international fiscal systems on reserves reporting

    International Nuclear Information System (INIS)

    McMichael, C.L.

    1996-01-01

    The effects of international fiscal systems on oil and gas reserves evaluation and reporting, was reviewed. The movement in reserves estimates with changing technical, political and economic conditions, was described. Difficulties associated with the evaluation and booking of reserves is largely due to the confusing duplication of terms. For example, explorationists refer to reserves as an undrilled prospect, while engineers refer to them as producing property. The financial analyst refers to reserves of a company, while governments refer to the reserves of the country. The importance of defining reserves with full knowledge of the specific regulations that govern the reporting of reserves externally, and the internal reporting requirements for business planning purposes, was stressed. 2 refs

  1. Uranium reserves and exploration activity

    International Nuclear Information System (INIS)

    Meehan, R.J.

    1975-01-01

    The strategy that ERDA plans to employ regarding resource appraisal is outlined. All types of uranium occurrences will be evaluated as sources of domestic ore reserves. Industry's exploration efforts will be compiled. These data will include information on land acquisition and costs, footage drilled and costs, estimates of exploration activities and expenditures, exploration for non-sandstone deposits, exploration in non-established areas, and foreign exploration plans and costs. Typical data in each of these areas are given

  2. Gas reserves, discoveries and production

    International Nuclear Information System (INIS)

    Saniere, A.

    2006-01-01

    Between 2000 and 2004, new discoveries, located mostly in the Asia/Pacific region, permitted a 71% produced reserve replacement rate. The Middle East and the offshore sector represent a growing proportion of world gas production Non-conventional gas resources are substantial but are not exploited to any significant extent, except in the United States, where they account for 30% of U.S. gas production. (author)

  3. Demand Response Spinning Reserve Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Eto, Joseph H.; Nelson-Hoffman, Janine; Torres, Carlos; Hirth,Scott; Yinger, Bob; Kueck, John; Kirby, Brendan; Bernier, Clark; Wright,Roger; Barat, A.; Watson, David S.

    2007-05-01

    The Demand Response Spinning Reserve project is a pioneeringdemonstration of how existing utility load-management assets can providean important electricity system reliability resource known as spinningreserve. Using aggregated demand-side resources to provide spinningreserve will give grid operators at the California Independent SystemOperator (CAISO) and Southern California Edison (SCE) a powerful, newtool to improve system reliability, prevent rolling blackouts, and lowersystem operating costs.

  4. Indian Reserves: Canada's Developing Nations

    OpenAIRE

    Musto, Richard J.

    1990-01-01

    Indian reserves are the most visible reminder of the separation of aboriginal people from the rest of Canada and other Canadians. Illness patterns and social conditions in Native communities closely parallel those in developing nations. While they continue to have a large burden of infectious diseases, these groups also have an increased incidence of chronic and lifestyle diseases as well as environment-related conditions. Similarities can be seen in urban areas between immigrants from abroad...

  5. Turbulent diffusion of lines and circulations

    Energy Technology Data Exchange (ETDEWEB)

    Eyink, Gregory L. [Department of Applied Mathematics and Statistics, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218 (United States)], E-mail: eyink@ams.jhu.edu

    2007-09-03

    We study material lines and passive vectors in a model of turbulent flow at infinite-Reynolds number, the Kraichnan-Kazantsev ensemble of velocities that are white-noise in time and rough (Hoelder continuous) in space. It is argued that the phenomenon of 'spontaneous stochasticity' generalizes to material lines and that conservation of circulations generalizes to a 'martingale property' of the stochastic process of lines.

  6. Foreign Exchange Reserves: Bangladesh Perspective

    Directory of Open Access Journals (Sweden)

    Md Zahangir Alam

    2013-10-01

    Full Text Available This study is about foreign exchangereserves of Bangladesh. The mainpurpose of this study is to the influence of exchange rates on foreign exchangereserves to the Bangladesh context.  Both the primary and secondary data has been used inthis study. The primary data has been collected through a structuredquestionnaire from 50 respondents. The secondary data, namely Bangladeshforeign exchange reserves (FER, Bangladesh current account balance (CAB,Bangladesh capital andfinancial account balance (CFAB, and BDT/USD exchange rates (ER.  This study covers yearly data from July 01,1996 to June 30, 2005 and quarterly data from July 01, 2005 to June 30, 2012. Findingsof this study shows that out of the selected 16 factors affecting foreignexchange reserves, exchange rates occupy the first position, weighted averagescore (WAS being 4.56. Foreign exchange reserves (FER and current accountbalance (CAB have increased by 502.9087% and 1451.218%,whereas capital and financial account (CFAB has decreased by -649.024% on June30, 2012 compared to June 30, 1997. The influence of other factors heldconstant, as ER changes by 285.6894 units due to one unit change in FER, onaverage in the same direction which represents that ER has positive effect on theFER and this relationship is statistically significant.  62.1526 percentof the variation in FER is explained by ER. The outcomes of Breusch-Godfrey test (LM test, ARCHtest, and the Normality test are that there is a serial correlation among residuals, the variance of residuals is notconstant, and the residuals are not normally distributed.

  7. Brain reserve and cognitive reserve in multiple sclerosis

    Science.gov (United States)

    Rocca, Maria A.; Leavitt, Victoria M.; Riccitelli, Gianna; Comi, Giancarlo; DeLuca, John; Filippi, Massimo

    2013-01-01

    Objective: We first tested the brain reserve (BR) hypothesis in multiple sclerosis (MS) by examining whether larger maximal lifetime brain volume (MLBV; determined by genetics) protects against disease-related cognitive impairment, and then investigated whether cognitive reserve (CR) gained through life experience (intellectually enriching leisure activities) protects against cognitive decline independently of MLBV (BR). Methods: Sixty-two patients with MS (41 relapsing-remitting MS, 21 secondary progressive MS) received MRIs to estimate BR (MLBV, estimated with intracranial volume [ICV]) and disease burden (T2 lesion load; atrophy of gray matter, white matter, thalamus, and hippocampus). Early-life cognitive leisure was measured as a source of CR. We assessed cognitive status with tasks of cognitive efficiency and memory. Hierarchical regressions were used to investigate whether higher BR (ICV) protects against cognitive impairment, and whether higher CR (leisure) independently protects against cognitive impairment over and above BR. Results: Cognitive status was positively associated with ICV (R2 = 0.066, p = 0.017). An ICV × disease burden interaction (R2 = 0.050, p = 0.030) revealed that larger ICV attenuated the impact of disease burden on cognition. Controlling for BR, higher education (R2 = 0.047, p = 0.030) and leisure (R2 = 0.090, p = 0.001) predicted better cognition. A leisure × disease burden interaction (R2 = 0.037, p = 0.030) showed that leisure independently attenuated the impact of disease burden on cognition. Follow-up analyses revealed that BR protected against cognitive inefficiency, not memory deficits, whereas CR was more protective against memory deficits than cognitive inefficiency. Conclusion: We provide evidence of BR in MS, and show that CR independently protects against disease-related cognitive decline over and above BR. Lifestyle choices protect against cognitive impairment independently of genetic factors outside of one's control

  8. Z' reservation at LEP2

    CERN Document Server

    Montagna, G.; Piccinini, F.; Renard, F.M.; Verzegnassi, C.

    1995-01-01

    We consider the possibility that one extra Z\\equiv Z' exists with arbitrary mass and fermion couplings that do not violate (charged) lepton universality. We show that, in such a situation, a functional relationship is generated between the \\underline{deviations} from the SM values of three leptonic observables of two-fermion production at future e^+e^- colliders that is completely independent of the values of the Z' mass and couplings. This selects a certain region in the 3-d space of the deviations that is \\underline{characteristic} of the model (Z' "reservation"). As a specific and relevant example, we show the picture that would emerge at LEP2 under realistic experimental conditions.

  9. Linear rotary optical delay lines

    Science.gov (United States)

    Guerboukha, Hichem; Qu, Hang; Skorobogatiy, Maksim

    2016-03-01

    We present a semi-analytical solution for the design of a high-speed rotary optical delay line that use a combination of two rotating curvilinear reflectors. We demonstrate that it is possible to design an infinite variety of the optical delay lines featuring linear dependence of the optical delay on the rotation angle. This is achieved via shape optimization of the rotating reflector surfaces. Moreover, a convenient spatial separation of the incoming and outgoing beams is possible. For the sake of example, we present blades that fit into a circle of 10cm diameter. Finally, a prototype of a rotary delay line is fabricated using CNC machining, and its optical properties are characterized.

  10. Cable line engineering

    International Nuclear Information System (INIS)

    Jang, Hak Sin; Kim, Sin Yeong

    1998-02-01

    This book is about cable line engineering. It is comprised of nine chapters, which deals with summary of cable communication such as way, process of cable communication and optical communication, Line constant of transmission on primary constant, reflection and crosstalk, communication cable line of types like flat cable, coaxial cable and loaded cable, Install of communication line with types and facility of aerial line, construction method of communication line facility, Measurement of communication line, Carrier communication of summary, PCM communication with Introduction, regeneration relay system sampling and quantization and Electric communication service and general information network with mobile communication technique and satellite communication system.

  11. Invasive Plant Management Plan for the Oak Ridge Reservation

    Energy Technology Data Exchange (ETDEWEB)

    Giffen, Neil R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McCracken, Kitty [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-09-01

    Invasive non-native plant species have become one of the greatest ecological threats across the country and around the world. Actively managing incursions of invasive plants is crucial to maintaining ecosystems, protecting natural resources, and ensuring proper function of facilities and their support infrastructures, power lines and other utility rights-of-way (ROWs), communications structures, roadways, and waterways. Invasive plants can threaten cultural resources, public and private properties, forests, wetlands, and other natural areas through increased risks of fire and storm damage, as well as decrease native plant diversity, particularly disrupting vital habitats of threatened and endangered species, both plant and animal. In 2000, the Federal Plant Protection Act came into effect. Under this Act, federal agencies are required to develop and coordinate an undesirable plants management program for control of invasive plants on federal lands under each agency’s respective jurisdiction. The agency must adequately fund the undesirable plants management program using an Integrated Pest Management Plan. Additionally, each agency is required to implement cooperative agreements with local and state agencies, as well as other federal agencies, to manage undesirable plants on federal lands under the agency’s jurisdiction. The US Department of Energy (DOE) takes its responsibility for addressing invasive and undesirable plant issues very seriously. Many DOE sites have programs to control invasive pest plant species. DOE has taken a proactive stance toward invasive plant control, and the Invasive Plant Management Plan— created to meet regulatory requirements of federal laws, executive orders, presidential memos, contracts, and agreements on DOE’s Oak Ridge Reservation (ORR)—has been in effect since 2004. This document represents the second revision of this plan.

  12. Reserves, resources and eve of bell-shaped curve peak of discovered reserves

    International Nuclear Information System (INIS)

    Dragicevic, T.; Kolundzic, S.

    2005-01-01

    Through the whole 20. century modern world was marked by accelerated development, and its progress was based, among other things, on sufficient and reliable energy supply. As fossil fuels have represented a large share in total energy sources with ever growing share of oil and natural gas consumption, in the 1990s serious concerns were raised about limited availability of these fuels. In line with the oil reserves life cycle theory presented by bell-shaped curve, M. King Hubbert predicted in 1956 that the U.S.A. would reach the peak of the curve in 1970 (which really happened). Other experts predicted that global oil reserves would reach their peak in the period 1990-2000, and now the new peaks are projected for 2006, 2009, 2013, 2020 and even 2030. Despite the fact that some predictions turned to be false, and despite our inclination to take a more optimistic view, we should face the fact that even the most optimistic 2030 is not far away. The term p eak oil , denoting the period when the known reserves would reach their production peaks, has been increasingly present in the literature and in the media. It does not implicate that oil reserves will disappear in one of the predicted years. Intense oil production will continue, but total reserves will decline. According to predictions, natural gas reserves are not expected to reach their peak before the end of the 21st century. Methane hydrates reserves could protrude throughout the 22nd century. Nevertheless, the peak oil phenomenon has serious implications for the mankind and for oil companies. The changes that will affect oil companies will not be equal for super-majors or majors and medium-sized and small-sized oil companies. Different are the ways that the changes will affect the countries with strong economies and those with weaker ones. Modern economies rely on fuel consumption. Moving people and goods from one place to another is not only the matter of transport and leisure. Availability and accessibility of

  13. rights reserved Geophysical Identification of Hydrothermally Altered

    African Journals Online (AJOL)

    ADOWIE PERE

    1984) that primary gold deposits are associated with ... parallel flight lines. Additional flight lines are flown in the perpendicular direction to assist in data processing. These large volumes of measurements then are processed into a digital ...

  14. Joint energy and reserve dispatch in a multi-area competitive market ...

    African Journals Online (AJOL)

    ... multi-product, multi-area market dispatch problem with physical and operational constraints. The proposed approach effectively handles the complex constraints like reserve requirements, zonal power balance constraints, area spinning reserve constraints, tie-line constraints and reserve and capacity coupling constraints.

  15. VT Electric Transmission Line Corridors - corridor lines

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The ELTRN layer depicts electric transmission line corridors in Vermont. Various methods have been used to digitize features. The data layer...

  16. Lined canvas paintings

    DEFF Research Database (Denmark)

    Krarup Andersen, Cecil

    2013-01-01

    This work evaluates the lining history of the Danish Golden Age collection of canvas paintings from the nineteenths century at SMK, The National Gallery of Denmark, and seeks to understand the moisture sensitivity of the paintings before and after lining. This is done by chemical analysis...... and tensile testing samples from the tacking edges as well as lined mock-up samples. The ability of the different lining techniques to support canvas paintings is evaluated in terms of their initial stretching and during fluctuations of relative humidity. Six different combinations of lining adhesives...... and textiles were examined. These included the adhesives Beva 371, Plextol D360, wax-resin, and glue-paste. The lining textiles were linen and polyester sailcloth. A naturally aged canvas painting and a modern painting were lined using these materials and methods. Testing of the lined paintings included uni...

  17. Federal Reserve System Semiannual Regulatory Agenda

    Science.gov (United States)

    2010-12-20

    ... [The Regulatory Plan and Unified Agenda of Federal Regulatory and Deregulatory Actions] [Federal Reserve System Semiannual Regulatory Agenda ] Part XXI Federal Reserve System Semiannual Regulatory Agenda... Flexibility Agenda AGENCY: Board of Governors of the Federal Reserve System. ACTION: Semiannual regulatory...

  18. Unit commitment with probabilistic reserve: An IPSO approach

    International Nuclear Information System (INIS)

    Lee, Tsung-Ying; Chen, Chun-Lung

    2007-01-01

    This paper presents a new algorithm for solution of the nonlinear optimal scheduling problem. This algorithm is named the iteration particle swarm optimization (IPSO). A new index, called iteration best, is incorporated into particle swarm optimization (PSO) to improve the solution quality and computation efficiency. IPSO is applied to solve the unit commitment with probabilistic reserve problem of a power system. The outage cost as well as fuel cost of thermal units was considered in the unit commitment program to evaluate the level of spinning reserve. The optimal scheduling of on line generation units was reached while minimizing the sum of fuel cost and outage cost. A 48 unit power system was used as a numerical example to test the new algorithm. The optimal scheduling of on line generation units could be reached in the testing results while satisfying the requirement of the objective function

  19. 41 CFR 101-1.112 - Change lines.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Change lines. 101-1.112 Section 101-1.112 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation System § 101-1.112 Change...

  20. Lined canvas paintings

    DEFF Research Database (Denmark)

    Krarup Andersen, Cecil

    2013-01-01

    and tensile testing samples from the tacking edges as well as lined mock-up samples. The ability of the different lining techniques to support canvas paintings is evaluated in terms of their initial stretching and during fluctuations of relative humidity. Six different combinations of lining adhesives...

  1. The role of new technologies in expanding useful coal reserves

    Energy Technology Data Exchange (ETDEWEB)

    Sligar, J. [Pacific Power, Sydney, NSW (Australia)

    1995-12-31

    The range of new high efficiency coal utilisation technologies for power generation will have a marked effect in increasing marketable coal reserves from world sources as the technologies are integrated into new and retrofitted power stations. These technologies are substantially more efficient than pulverised coal technology; so if marketable coal reserves are viewed as energy reserves there will be an increase of at least 28% due to this factor alone. In addition, the new technologies use coals with different sets of properties to present internationally traded coals. In many cases reserves of these coals exist but are not presently included in reserves for power generation but which will need to be included in the future. These changes, which require a reassessment of marketable resources for the reliable generation of cheap and environmentally friendly energy and generally extend coal resources by a conservative 33%.

  2. Economic Development Benefits of New Transit Service: RiverLINE

    Science.gov (United States)

    2010-06-01

    This report documents the economic impacts of the RiverLINE, a light rail line connecting Trenton and Camden, New Jersey. The study examined whether and how the line impacted local land use, residential property values, travel behaviors and firm perf...

  3. 76 FR 16620 - National Estuarine Research Reserve System

    Science.gov (United States)

    2011-03-24

    ... plans for future land acquisition and facility development to support reserve operations. The objectives... information to key decisionmakers; and added significant monitoring of emergent marsh vegetation, water... maritime forest, coastal shrub, wetlands, tidal marshes and sand beaches. The property provides important...

  4. Commercial helium reserves, continental rifting and volcanism

    Science.gov (United States)

    Ballentine, C. J.; Barry, P. H.; Hillegonds, D.; Fontijn, K.; Bluett, J.; Abraham-James, T.; Danabalan, D.; Gluyas, J.; Brennwald, M. S.; Pluess, B.; Seneshens, D.; Sherwood Lollar, B.

    2017-12-01

    Helium has many industrial applications, but notably provides the unique cooling medium for superconducting magnets in medical MRI scanners and high energy beam lines. In 2013 the global supply chainfailed to meet demand causing significant concern - the `Liquid Helium Crisis' [1]. The 2017 closure of Quatar borders, a major helium supplier, is likely to further disrupt helium supply, and accentuates the urgent need to diversify supply. Helium is found in very few natural gas reservoirs that have focused 4He produced by the dispersed decay (a-particle) of U and Th in the crust. We show here, using the example of the Rukwa section of the Tanzanian East African Rift, how continental rifting and local volcanism provides the combination of processes required to generate helium reserves. The ancient continental crust provides the source of 4He. Rifting and associated magmatism provides the tectonic and thermal mechanism to mobilise deep fluid circulation, focusing flow to the near surface along major basement faults. Helium-rich springs in the Tanzanian Great Rift Valley were first identified in the 1950's[2]. The isotopic compositions and major element chemistry of the gases from springs and seeps are consistent with their release from the crystalline basement during rifting [3]. Within the Rukwa Rift Valley, helium seeps occur in the vicinity of trapping structures that have the potential to store significant reserves of helium [3]. Soil gas surveys over 6 prospective trapping structures (1m depth, n=1486) show helium anomalies in 5 out of the 6 at levels similar to those observed over a known helium-rich gas reservoir at 1200m depth (7% He - Harley Dome, Utah). Detailed macroseep gas compositions collected over two days (n=17) at one site allows us to distinguish shallow gas contributions and shows the deep gas to contain between 8-10% helium, significantly increasing resource estimates based on uncorrected values (1.8-4.2%)[2,3]. The remainder of the deep gas is

  5. 24 CFR 891.605 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 891.605... 8 Assistance § 891.605 Replacement reserve. (a) Establishment of reserve. The Borrower shall establish and maintain a replacement reserve to aid in funding extraordinary maintenance, and repair and...

  6. 24 CFR 891.405 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 891.405....405 Replacement reserve. (a) Establishment of reserve. The Owner shall establish and maintain a replacement reserve to aid in funding extraordinary maintenance and repair and replacement of capital items...

  7. Relativistic Hartree theory for nuclei far from the stability line

    International Nuclear Information System (INIS)

    Hirata, D.; Toki, H.; Watabe, T.; Tanihata, I.; Carlson, B.V.

    1991-01-01

    We study nuclei far from the stability line using the relativistic Hartree theory. We calculate the properties of various elements of the Periodic Table up to the proton and neutron drip lines with several parameter sets. After comparing the numerical results, we discuss nuclear properties near the drip lines in detail for the parameter sets that include nonlinear terms in the sigma-meson Lagrangian

  8. Cross delay line sensor characterization

    Energy Technology Data Exchange (ETDEWEB)

    Owens, Israel J [Los Alamos National Laboratory; Remelius, Dennis K [Los Alamos National Laboratory; Tiee, Joe J [Los Alamos National Laboratory; Buck, Steven E [Los Alamos National Laboratory; Whittemore, Stephen R [Los Alamos National Laboratory; Thompson, David C [Los Alamos National Laboratory; Shirey, Robert [Los Alamos National Laboratory

    2010-01-01

    There exists a wealth of information in the scientific literature on the physical properties and device characterization procedures for complementary metal oxide semiconductor (CMOS), charge coupled device (CCD) and avalanche photodiode (APD) format detectors. Numerous papers and books have also treated photocathode operation in the context of photomultiplier tube (PMT) operation for either non imaging applications or limited night vision capability. However, much less information has been reported in the literature about the characterization procedures and properties of photocathode detectors with novel cross delay line (XDL) anode structures. These allow one to detect single photons and create images by recording space and time coordinate (X, Y & T) information. In this paper, we report on the physical characteristics and performance of a cross delay line anode sensor with an enhanced near infrared wavelength response photocathode and high dynamic range micro channel plate (MCP) gain (> 10{sup 6}) multiplier stage. Measurement procedures and results including the device dark event rate (DER), pulse height distribution, quantum and electronic device efficiency (QE & DQE) and spatial resolution per effective pixel region in a 25 mm sensor array are presented. The overall knowledge and information obtained from XDL sensor characterization allow us to optimize device performance and assess capability. These device performance properties and capabilities make XDL detectors ideal for remote sensing field applications that require single photon detection, imaging, sub nano-second timing response, high spatial resolution (10's of microns) and large effective image format.

  9. Mathematical model of subscriber extension line

    OpenAIRE

    Petříková, Iva; Diviš, Zdeněk; Tesař, Zdeněk

    2012-01-01

    The paper focuses on measurement properties of metallic subscriber extension lines to build regression mathematical model for a symmetric pair cable. The regression model is compared with an analytical model based on a theoretical description of transfer parameters for this type of line. The output of the paper should demonstrate the impact of electromagnetic interference on the symmetric pair. The paper also describes the method to identify the interference sources and ...

  10. Cognitive Reserve: Implications for Assessment and Intervention

    OpenAIRE

    Stern, Yaakov

    2013-01-01

    The concept of reserve is used to explain the observation that some individuals function better than others in the presence of brain pathology. This paper reviews the concept of reserve from its theoretical basis to the implication of reserve for clinical practice. A distinction between brain reserve, referring to individual differences in the anatomic substrate, and cognitive reserve, referring to differences in the flexibility or adaptivity of cognitive networks, is useful. Epidemiologic ev...

  11. BEAM TRANSPORT LINES FOR THE BSNS.

    Energy Technology Data Exchange (ETDEWEB)

    WEI, J.

    2006-06-26

    This paper presents the design of two beam transport lines at the BSNS: one is the injection line from the Linac to the RCS and the other is the target line from the RCS to the target station. In the injection beam line, space charge effects, transverse halo collimation, momentum tail collimation and debunching are the main concerned topics. A new method of using triplet cells and stripping foils is used to collimate transverse halo. A long straight section is reserved for the future upgrading linac and debuncher. In the target beam line, large halo emittance, beam stability at the target due to kicker failures and beam jitters, shielding of back-scattering neutrons from the target are main concerned topics. Special bi-gap magnets will be used to reduce beam losses in the collimators in front of the target.

  12. Narrow line profiles and interacting gas flows in active galaxies

    International Nuclear Information System (INIS)

    Mardaljevic, J.; Raine, D.J.; Smith, M.D.

    1986-01-01

    The 'catapult model' of the narrow line region involves both infalling and outflowing clouds interacting with an outflowing wind. The emission line profiles in this model are derived and the results compared with observation. Supersonic and subsonic winds in the interaction zone produce distinct line profiles, both of which are observed. Flat-topped profiles, the presence of broad wings, asymmetry and line shifts are discussed. A relationship between profile shape and X-ray properties is predicted. (author)

  13. Assessment of secondary aluminum reserves of nations

    DEFF Research Database (Denmark)

    Maung, Kyaw Nyunt; Yoshida, Tomoharu; Liu, Gang

    2017-01-01

    A classification framework of the secondary resources was applied to evaluate the framework's applicability and to assess secondary aluminum reserves for 19 countries. Estimated amounts of secondary aluminum reserves in 2010 were 85 million tonnes in the United States, 65 million tonnes in China......, 29 million tonnes in Japan, and 413 million tonnes globally. For the United States, its secondary reserves are larger than its primary reserves, although the global primary reserves (28,000 million tonnes) are much larger than the estimated secondary reserves. Considerable amounts of secondary...

  14. Estimating cognitive reserve in healthy adults using the Cognitive Reserve Scale.

    Directory of Open Access Journals (Sweden)

    Irene León

    Full Text Available The concept of cognitive reserve emerged from observed disparities between brain pathology and clinical symptoms. It may explain better neuropsychological performance in healthy individuals. The objectives of this study were to measure reserve in healthy subjects using a new Cognitive Reserve Scale (CRS, analyze the internal consistency of the CRS, and analyze validity evidence. A total of 117 healthy individuals were divided into two groups: 87 adults (aged 18-64 years and 30 elderly adults (≥65 years. All subjects completed the CRS and a comprehensive neuropsychological battery. The internal consistency of the scale was satisfactory (α = 0.77. No significant differences were observed between genders (t = 0.51, p = 0.611, and age was corrected by averaging the CRS score. The study of validity evidence showed that education affected the CRS (t = -2.98, p = 0.004, partial h2 = 0.07 and there was no significant relationship between the CRS and IQ (r = 0.09, p = 0.33. Occupational attainment and the CRS were not related (F2,116 = 0.11, p = 0.898. In line with previous studies on reserve, heterogeneity was observed in the analyses of relationships between the CRS and cognitive performance. There were significant relationships between CRS score and the Verbal Learning Spanish-Complutense Test last trial (r = 0.24, p = 0.009, sum (r = 0.32, p = 0.000, short-term (r = 0.29, p = 0.002 and long-term memory (r = 0.22, p = 0.018, Matrix Reasoning subtest (r = 0.20, p = 0.027 and Block Design subtest (r = 0.20, p = 0.029. No other neuropsychological variables correlated with the CRS (p>0.05. The CRS is a reliable instrument that reflects the frequency of participation in brain-stimulating activities across the lifetime. The associations between the CRS and education and neuropsychological performance support validity evidence.

  15. Estimating Cognitive Reserve in Healthy Adults Using the Cognitive Reserve Scale

    Science.gov (United States)

    León, Irene; García-García, Juan; Roldán-Tapia, Lola

    2014-01-01

    The concept of cognitive reserve emerged from observed disparities between brain pathology and clinical symptoms. It may explain better neuropsychological performance in healthy individuals. The objectives of this study were to measure reserve in healthy subjects using a new Cognitive Reserve Scale (CRS), analyze the internal consistency of the CRS, and analyze validity evidence. A total of 117 healthy individuals were divided into two groups: 87 adults (aged 18–64 years) and 30 elderly adults (≥65 years). All subjects completed the CRS and a comprehensive neuropsychological battery. The internal consistency of the scale was satisfactory (α = 0.77). No significant differences were observed between genders (t = 0.51, p = 0.611), and age was corrected by averaging the CRS score. The study of validity evidence showed that education affected the CRS (t = −2.98, p = 0.004, partial h2 = 0.07) and there was no significant relationship between the CRS and IQ (r = 0.09, p = 0.33). Occupational attainment and the CRS were not related (F2,116 = 0.11, p = 0.898). In line with previous studies on reserve, heterogeneity was observed in the analyses of relationships between the CRS and cognitive performance. There were significant relationships between CRS score and the Verbal Learning Spanish–Complutense Test last trial (r = 0.24, p = 0.009), sum (r = 0.32, p = 0.000), short-term (r = 0.29, p = 0.002) and long-term memory (r = 0.22, p = 0.018), Matrix Reasoning subtest (r = 0.20, p = 0.027) and Block Design subtest (r = 0.20, p = 0.029). No other neuropsychological variables correlated with the CRS (p>0.05). The CRS is a reliable instrument that reflects the frequency of participation in brain-stimulating activities across the lifetime. The associations between the CRS and education and neuropsychological performance support validity evidence. PMID:25050711

  16. Cognitive Reserve: Implications for Assessment and Intervention

    Science.gov (United States)

    Stern, Yaakov

    2014-01-01

    The concept of reserve is used to explain the observation that some individuals function better than others in the presence of brain pathology. This paper reviews the concept of reserve from its theoretical basis to the implication of reserve for clinical practice. A distinction between brain reserve, referring to individual differences in the anatomic substrate, and cognitive reserve, referring to differences in the flexibility or adaptivity of cognitive networks, is useful. Epidemiologic evidence indicates that a set of life exposures including higher educational and occupational attainment, and engaging in leisure activities is associated with a lower risk of incident dementia, suggesting that these life exposures may enhance cognitive reserve. This provides a basis for controlled clinical studies can test specific exposures that may enhance reserve. The concept of cognitive reserve also has important implications for clinical practice in terms of diagnosis and prognosis. PMID:23941972

  17. Clipboard: Unraveling the mystery of cognitive reserve

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 40; Issue 2. Clipboard : Unraveling the mystery of cognitive reserve ... Keywords. Aging; Alzheimer's; bilingualism; cognitive reserve; dementia; Down's; education; enrichment; environment; learning; long term potentiation; LTP; memory; neuroepigenetics; plasticity ...

  18. Transforming the Reserve Component: Four Essays

    National Research Council Canada - National Science Library

    Binnendijk, Hans; Baranick, Michael J; Bell, Raymond E., Jr; Cordero, Gina; Duncan, Stephen M; Holshek, Christopher; Wentz, Larry

    2005-01-01

    This volume contains four essays on various aspects of the Reserve Component. We publish it at a time when Reserves are serving overseas at historically high rates and when new missions like homeland security demand their attention...

  19. 5 CFR 330.610 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false [Reserved] 330.610 Section 330.610 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND... Employees § 330.610 [Reserved] ...

  20. 5 CFR 330.603 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false [Reserved] 330.603 Section 330.603 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND... Employees § 330.603 [Reserved] ...

  1. Reserving by detailed conditioning on individual claim

    Science.gov (United States)

    Kartikasari, Mujiati Dwi; Effendie, Adhitya Ronnie; Wilandari, Yuciana

    2017-03-01

    The estimation of claim reserves is an important activity in insurance companies to fulfill their liabilities. Recently, reserving method of individual claim have attracted a lot of interest in the actuarial science, which overcome some deficiency of aggregated claim method. This paper explores the Reserving by Detailed Conditioning (RDC) method using all of claim information for reserving with individual claim of liability insurance from an Indonesian general insurance company. Furthermore, we compare it to Chain Ladder and Bornhuetter-Ferguson method.

  2. Geophysical investigations in the territory of Bolgar state historical and architectural museum-reserve in 2014

    Directory of Open Access Journals (Sweden)

    Brednikov Konstantin I.

    2015-09-01

    Full Text Available The results of geophysical investigations which was carried out in 2014 in the territory of Bolgar State Historical and Architectural Museum-Reserve are reviewed in the article. Territory of Bolgar State Historical and Architectural Museum-Reserve is part of the UNESCO protected sites. The set of works included wide range of geophysical investigations: magnetometry, gravimetry, electrical prospecting and georadar. The main goal of investigations was detecting and localization of archaeological objects remnant (houses, mausoleums, kilns, etc.. Magnetometry was the basic method during carrying out the works. Magnetic measurements are used in the practice of archaeological investigations very widely due to the high informativeness and productiveness of this method. The major search objects are the brick bases and building walls, accumulation of fired ceramic, the remnants of furnace construction for various purposes. Georadar survey, gravity and electrical prospecting were used for localization of nonmagnetic objects. It is identified a line of objects differing in its properties and purpose as a result of research. There are furnaces, mausoleum bases, remains of domestic buildings. Methodology for conducting of field experiments has been refined and optimized in the process of carrying out of geophysical investigations.

  3. Electronic health record solutions to reduce central line-associated bloodstream infections by enhancing documentation of central line insertion practices, line days, and daily line necessity.

    Science.gov (United States)

    Quan, Kathleen A; Cousins, Sarah M; Porter, Darlene D; O'Brien, Margaret; Rudkin, Scott; Lambertson, Brian; Hoang, Dennis; Dangodara, Amish A; Huang, Susan S

    2016-04-01

    Central line-associated bloodstream infections (CLABSIs) continue to cause preventable morbidity and mortality, but methods for tracking and ensuring consistency of CLABSI-prevention activities remain underdeveloped. We created an integrated electronic health record solution to prompt sterile central venous catheter (CVC) insertion, CVC tracking, and timely line removal. The system embedded central line insertion practices (CLIP) elements in inserter procedure notes, captured line days and new lines, matching each with its CLIP form and feeding back compliance, and enforced daily documentation of line necessity in physician progress notes. We examined changes in CLIP compliance and form submission, number of new line insertions captured, and necessary documentation. Standard reporting of CLIP compliance, which measures compliance per CLIP form received, artificially inflated CLIP compliance relative to compliance measured using CVC placements as the denominator; for example, 99% per CLIP form versus 55% per CVC placement. This system established a higher threshold for CLIP compliance using this denominator. Identification of CVCs increased 35%, resulting in a decrease in CLABSI rates. The system also facilitated full compliance with daily documentation of line necessity. Integrated electronic health records systems can help realize the full benefit of CLABSI prevention strategies by promoting, tracking, and raising the standard for best practices behavior. Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  4. Poverty and corruption compromise tropical forest reserves.

    Science.gov (United States)

    Wright, S Joseph; Sanchez-Azofeifa, G Arturo; Portillo-Quintero, Carlos; Davies, Diane

    2007-07-01

    We used the global fire detection record provided by the satellite-based Moderate Resolution Imaging Spectroradiometer (MODIS) to determine the number of fires detected inside 823 tropical and subtropical moist forest reserves and for contiguous buffer areas 5, 10, and 15 km wide. The ratio of fire detection densities (detections per square kilometer) inside reserves to their contiguous buffer areas provided an index of reserve effectiveness. Fire detection density was significantly lower inside reserves than in paired, contiguous buffer areas but varied by five orders of magnitude among reserves. The buffer: reserve detection ratio varied by up to four orders of magnitude among reserves within a single country, and median values varied by three orders of magnitude among countries. Reserves tended to be least effective at reducing fire frequency in many poorer countries and in countries beset by corruption. Countries with the most successful reserves include Costa Rica, Jamaica, Malaysia, and Taiwan and the Indonesian island of Java. Countries with the most problematic reserves include Cambodia, Guatemala, Paraguay, and Sierra Leone and the Indonesian portion of Borneo. We provide fire detection density for 3964 tropical and subtropical reserves and their buffer areas in the hope that these data will expedite further analyses that might lead to improved management of tropical reserves.

  5. 24 CFR 572.125 - Replacement reserves.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Replacement reserves. 572.125...) Homeownership Program Requirements-Implementation Grants § 572.125 Replacement reserves. (a) Purpose. A single replacement reserve may be established for the homeownership program only if HUD determines it is necessary to...

  6. 24 CFR 880.602 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 880.602... Replacement reserve. (a) A replacement reserve must be established and maintained in an interest-bearing account to aid in funding extraordinary maintenance and repair and replacement of capital items. (1) Part...

  7. 24 CFR 891.745 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 891.745... and Individuals-Section 162 Assistance § 891.745 Replacement reserve. The general requirements for the replacement reserve are provided in § 891.605. For projects funded under §§ 891.655 through 891.790, the...

  8. Reserve evaluation of minerals at NUCLEBRAS

    International Nuclear Information System (INIS)

    Marques, J.P.M.; Guerra, P.A.G.; Vinha, C.A.G. da

    1980-10-01

    The method used for the reserve evaluation of minerals, particularly of uranium, as used worldwide, and specially at NUCLEBRAS is described. This is done through a series of procedures envolving basic definitions, reserve evaluation methods (conventional, statistical and geoestatistical), data management, use of computer systems, classification and evaluation of reserves. (Author) [pt

  9. John Brainerd and the First Indian Reservation.

    Science.gov (United States)

    Harper, Susanne Banta

    1979-01-01

    Describes the humanitarian founding in 1758 of the nation's first reservation--the Brotherton reservation for New Jersey's Lenni Lenape (Algonquin) Indians. The people were demoralized, sick, and decimated in numbers; and so the venture failed. In 1801 those few remaining sold the reservation and moved to join related tribes in New York. (DS)

  10. Glue-paste linings

    DEFF Research Database (Denmark)

    Fuster-López, Laura; Andersen, Cecil Krarup; Bouillon, Nicolas

    2017-01-01

    processes of lined canvas paintings. The impact of cyclic relative humidity on the biological and physical stability of the laminate structure is reported. Carefully constructed mock-ups, simulating lined canvas paintings, were used to examine the effect of pest infestation, mould growth, mechanical damage...

  11. Minnesota County Boundaries - lines

    Data.gov (United States)

    Minnesota Department of Natural Resources — Minnesota county boundaries derived from a combination of 1:24,000 scale PLS lines, 1:100,000 scale TIGER, 1:100,000 scale DLG, and 1:24,000 scale hydrography lines....

  12. Modeling operational behavior of a disassembly line

    Science.gov (United States)

    Kizilkaya, Elif A.; Gupta, Surendra M.

    2004-12-01

    In this paper we present a dynamic kanban (pull) system specifically developed for disassembly lines. This type of kanban system is much more complex than the traditional kanban system used in assembly lines. For instance, unlike the assembly line where the external demand occurs only at the last station, the demands in the disassembly case also occur at any of the intermittent stations. The reason is that as a product moves on the disassembly line, various parts are disassembled at every station and accumulated at that station. Therefore, there are as many demand sources as there are number of parts. We consider a case example involving the end-of-life products. Based on the precedence relationships and other criteria such as hazardous properties of the parts, we balance the disassembly line. The results of the disassembly line-balancing problem (DLBP) are used as input to the proposed dynamic kanban system for disassembly line (DKSDL). We compare the performance of the DKSDL to the modified kanban system for disassembly line (MKSDL), which was previously introduced by the authors. We show, via simulation, that the DKSDL is far superior to MKSDL considered.

  13. Cognitive reserve in ageing and Alzheimer's disease

    Science.gov (United States)

    Stern, Yaakov

    2012-01-01

    The concept of reserve accounts for individual differences in susceptibility to age-related brain changes or Alzheimer's disease-related pathology. There is evidence that some people can tolerate more of these changes than others and still maintain function. Epidemiologic studies suggest that lifetime exposures including educational and occupational attainment, and leisure activities in late life, can increase this reserve. For example, there is a reduced risk of developing Alzheimer's disease in individuals with higher educational or occupational attainment. It is convenient to think of two types of reserve: brain reserve, which refers to actual differences in the brain itself that may increase tolerance of pathology, and cognitive reserve. Cognitive reserve refers to individual differences in how tasks are performed that may allow some people to be more resilient than others. The concept of cognitive reserve holds out the promise of interventions that could slow cognitive aging or reduce the risk of dementia. PMID:23079557

  14. A biophysical analysis of latitudinal tree line

    Science.gov (United States)

    Goetz, S. J.; Loranty, M. M.; Berner, L.; Jin, Y.; Randerson, J. T.

    2011-12-01

    Northern latitudinal tree line represents the interface between boreal forests and tundra ecosystems, and is the ecophysiological limit of tree recruitment and persistence. The transition between tundra and forest is typically gradual, occurring over tens to hundreds of kilometers. This gradient represents a substantial change in the biophysical properties of the earth surface, one that is particularly important in ecosystems that are snow covered for much of the year. Tree line is, however, commonly delineated by the point of the northern most tree, with no gradient between forested and non-forested ecosystems. As a consequence crisp delineations of tree line incorporated into models introduce error in surface radiation budgets due to inaccurate albedo representations. Errors in modeled carbon and water fluxes are likely as well. Here we use satellite observations to quantify several key biophysical properties across latitudinal tree line for a series of sites throughout the pan-boreal region We find decreases in NDVI and increases in albedo across the transition from boreal forest to tundra, as expected. However, in the absence of topographical barriers we find that these transitions can occur over upwards of 100 km, and that biophysical properties characteristic of tundra ecosystems can occur as far as 100 km south of tree line. This suggests that land surface models likely overestimate surface radiation budgets and carbon fluxes in the boreal biome. We discuss our results in the context of land surface models, noting specific examples from archived model runs.

  15. Electrical and Biological Effects of Transmission Lines: A Review.

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jack M.

    1989-06-01

    This review describes the electrical properties of a-c and d-c transmission lines and the resulting effects on plants, animals, and people. Methods used by BPA to mitigate undesirable effects are also discussed. Although much of the information in this review pertains to high-voltage transmission lines, information on distribution lines and electrical appliances is included. The electrical properties discussed are electric and magnetic fields and corona: first for alternating-current (a-c) lines, then for direct current (d-c).

  16. Cell line provenance.

    Science.gov (United States)

    Freshney, R Ian

    2002-07-01

    Cultured cell lines have become an extremely valuable resource, both in academic research and in industrial biotechnology. However, their value is frequently compromised by misidentification and undetected microbial contamination. As detailed elsewhere in this volume, the technology, both simple and sophisticated, is available to remedy the problems of misidentification and contamination, given the will to apply it. Combined with proper records of the origin and history of the cell line, assays for authentication and contamination contribute to the provenance of the cell line. Detailed records should start from the initiation or receipt of the cell line, and should incorporate data on the donor as well as the tissue from which the cell line was derived, should continue with details of maintenance, and include any accidental as well as deliberate deviations from normal maintenance. Records should also contain details of authentication and regular checks for contamination. With this information, preferably stored in a database, and suitable backed up, the provenance of the cell line so created makes the cell line a much more valuable resource, fit for validation in industrial applications and more likely to provide reproducible experimental results when disseminated for research in other laboratories.

  17. Strategic Petroleum Reserve annual/quarterly report

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-16

    During 1992 the Department continued planning activities for the expansion of the Strategic Petroleum Reserve to one billion barrels. A draft Environmental Impact Statement for the five candidate sites was completed in October 1992, and a series of public hearings was held during December 1992. Conceptual design engineering activities, life cycle cost estimates and geotechnical studies to support the technical requirements for an Strategic Petroleum Reserve Plan Amendment were essentially completed in December 1992. At the end of 1992, the Strategic Petroleum Reserve crude oil inventory was 574.7 million barrels and an additional 1.7 million barrels was in transit to the Reserve. During 1992 approximately 6.2 million barrels of crude oil were acquired for the Reserve. A Department of Energy Tiger Team Environmental, Safety and Health (ES&H) Assessment was conducted at the Strategic Petroleum Reserve from March 9 through April 10, 1992. In general, the Tiger Team found that Strategic Petroleum Reserve activities do not pose undue environmental, safety or health risks. The Strategic Petroleum Reserve`s Final Corrective Action Plan, prepared in response to the Tiger Team assessment, was submitted for Department approval in December 1992. On November 18, 1992, the Assistant Secretary for Fossil Energy selected DynMcDennott Petroleum Operations Company to provide management and operating services for the Strategic Petroleum Reserve for a period of 5 years commencing April 1, 1993. DynMcDermott will succeed Boeing Petroleum Services, Inc.

  18. Demand for International Reserves in Turkey

    Directory of Open Access Journals (Sweden)

    Yimaz Sinem

    2014-06-01

    Full Text Available Having an important place in the international monetary system, international reserves held by central bank usually reflect country’s economic strength in terms of international finance and trade. There are many reasons for holding international reserves by central banks such as financing the deficit in the balance of payment, managing the monetary and exchange rate policies, minimizing the negative effects of external shocks and reducing the cost of borrowing. Continuously changing and diversifying characteristics of these reasons affect the demand for reserves depending to the economic conditions of the country. Over the last ten years, there has been a tremendous increase in international reserves held by Turkish Central Bank. From 2002 to 2012, the reserves of the bank have risen from 20 billion dollars to 96 billion dollars, showing an increase more than four times. This sudden and huge increase in the foreign reserves drove us to determine and investigate the factors which induce the Turkish Central Bank to hold high level of reserves. Thus, the purpose of this study is to estimate and analyze the demand for international reserves held by central banks using the buffer stock model in the case of Turkey. The data used in the study is monthly and cover the period of 1990:03-2012:10. The buffer stock model was econometrically estimated by using the OLS method for three different models. Our findings indicate that the opportunity cost affected reserve demand much stronger than the reserve volatility in Turkish case.

  19. Naval Petroleum and Oil Shale Reserves

    International Nuclear Information System (INIS)

    1992-01-01

    During fiscal year 1992, the reserves generated $473 million in revenues, a $181 million decrease from the fiscal year 1991 revenues, primarily due to significant decreases in oil and natural gas prices. Total costs were $200 million, resulting in net cash flow of $273 million, compared with $454 million in fiscal year 1991. From 1976 through fiscal year 1992, the Naval Petroleum and Oil Shale Reserves generated more than $15 billion in revenues and a net operating income after costs of $12.5 billion. In fiscal year 1992, production at the Naval Petroleum Reserves at maximum efficient rates yielded 26 million barrels of crude oil, 119 billion cubic feet of natural gas, and 164 million gallons of natural gas liquids. From April to November 1992, senior managers from the Naval Petroleum and Oil Shale Reserves held a series of three workshops in Boulder, Colorado, in order to build a comprehensive Strategic Plan as required by Secretary of Energy Notice 25A-91. Other highlights are presented for the following: Naval Petroleum Reserve No. 1--production achievements, crude oil shipments to the strategic petroleum reserve, horizontal drilling, shallow oil zone gas injection project, environment and safety, and vanpool program; Naval Petroleum Reserve No. 2--new management and operating contractor and exploration drilling; Naval Petroleum Reserve No. 3--steamflood; Naval Oil Shale Reserves--protection program; and Tiger Team environmental assessment of the Naval Petroleum and Oil Shale Reserves in Colorado, Utah, and Wyoming

  20. Wood pole overhead lines

    CERN Document Server

    Wareing, Brian

    2005-01-01

    This new book concentrates on the mechanical aspects of distribution wood pole lines, including live line working, environmental influences, climate change and international standards. Other topics include statutory requirements, safety, profiling, traditional and probabilistic design, weather loads, bare and covered conductors, different types of overhead systems, conductor choice, construction and maintenance. A section has also been devoted to the topic of lightning, which is one of the major sources of faults on overhead lines. The book focuses on the effects of this problem and the strate

  1. Evaluations of thyme extract effects in human normal bronchial and tracheal epithelial cell lines and in human lung cancer cell line.

    Science.gov (United States)

    Oliviero, Marinelli; Romilde, Iannarelli; Beatrice, Morelli Maria; Matteo, Valisi; Giovanna, Nicotra; Consuelo, Amantini; Claudio, Cardinali; Giorgio, Santoni; Filippo, Maggi; Massimo, Nabissi

    2016-08-25

    Thyme (Thymus vulgaris) is used traditionally to prepare herbal remedies possessing expectorant, mucolytic, antitussive and antispasmodic properties. The aim of the present study was to investigate the effects of a standardized hydroalcoholic extract of thyme on primary human airway (bronchial/tracheal) epithelial cell lines in a model of lung inflammation induced by LPS. In addition, the effects of thyme extract on human lung cancer cell line (H460) were analysed. Thyme extract showed significant anti-inflammatory properties by reducing the NF-κB p65 and NF-κB p52 transcription factors protein levels followed by the decrease of pro-inflammatory cytokines (IL-1 beta and IL-8), and Muc5ac secretion in human normal bronchial and tracheal epithelial cells. Moreover, the extract showed cytotoxic effects on H460 cancer cells, modulated the release of IL-1 beta, IL-8 and down-regulated NF-κB p65 and NF-κB p52 proteins. Taken together, these results substantiated the traditional uses of thyme in the treatment of respiratory diseases. Thyme extract might be an effective treatment of chronic diseases based on inflammatory processes when hypersecretion of mucus overwhelms the ciliary clearance and obstructs airways, causing morbidity and mortality. Moreover thyme extract, evaluated in H460 lung cancer cell line, demonstrated to induce cell cytotoxicity in addition to reduce inflammatory cell signals. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  2. A General Business Model for Marine Reserves

    Science.gov (United States)

    Sala, Enric; Costello, Christopher; Dougherty, Dawn; Heal, Geoffrey; Kelleher, Kieran; Murray, Jason H.; Rosenberg, Andrew A.; Sumaila, Rashid

    2013-01-01

    Marine reserves are an effective tool for protecting biodiversity locally, with potential economic benefits including enhancement of local fisheries, increased tourism, and maintenance of ecosystem services. However, fishing communities often fear short-term income losses associated with closures, and thus may oppose marine reserves. Here we review empirical data and develop bioeconomic models to show that the value of marine reserves (enhanced adjacent fishing + tourism) may often exceed the pre-reserve value, and that economic benefits can offset the costs in as little as five years. These results suggest the need for a new business model for creating and managing reserves, which could pay for themselves and turn a profit for stakeholder groups. Our model could be expanded to include ecosystem services and other benefits, and it provides a general framework to estimate costs and benefits of reserves and to develop such business models. PMID:23573192

  3. Substantiating the Incurred but not Reported Reserve

    Directory of Open Access Journals (Sweden)

    Georgeta Vintilã

    2009-12-01

    Full Text Available In order to handle past and future liability taken by insurance contracts concluded, any insurance company must constitute and maintain technical reserves. Substantiating technical reserves is done through actuarial methods and its over-evaluation or under-evaluation influence solvency and financial performance of the insurance companies, in the sense of reducing solvency through over-evaluating reserves and, respectively, influencing profit (hence of outstanding tax through under-evaluating reserves. An important reserve for insurance companies is represented by the incurred but not reported reserve, as it allows the estimation of the liability the company may confront in the future, generated by events occurred in the past, which are not currently known in the present but will be reported in the future.

  4. A Policy Analysis of Reserve Retirement Reform

    Science.gov (United States)

    2013-01-01

    adapted their manning requirements to this retention. Perhaps tasks and jobs have been designed to accommodate the reten - tion profile produced by the...a reward for a long career of service, a benefit to help transition to the civilian economy, and a means of securing the reten - tion of career...to determine their likely effect on active reten - tion, reserve affiliation after leaving an active component, reserve retention, and reserve

  5. IGT calculates world reserves of fossil fuels

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    The Institute of Gas Technology has published the IGT World Reserves Survey, giving their latest tabulation of world reserves of fossil fuels and uranium. The report contains 120 Tables and 41 Figures. Estimates are provided for proved reserves, resources, current production, and life indexes of the non-renewable energy sources of the US and of the world as a whole. World regional data are also provided in many cases. The data are summarized here. 2 figures, 5 tables

  6. Reserve valuation in electric power systems

    Science.gov (United States)

    Ruiz, Pablo Ariel

    Operational reliability is provided in part by scheduling capacity in excess of the load forecast. This reserve capacity balances the uncertain power demand with the supply in real time and provides for equipment outages. Traditionally, reserve scheduling has been ensured by enforcing reserve requirements in the operations planning. An alternate approach is to employ a stochastic formulation, which allows the explicit modeling of the sources of uncertainty. This thesis compares stochastic and reserve methods and evaluates the benefits of a combined approach for the efficient management of uncertainty in the unit commitment problem. Numerical studies show that the unit commitment solutions obtained for the combined approach are robust and superior with respect to the traditional approach. These robust solutions are especially valuable in areas with a high proportion of wind power, as their built-in flexibility allows the dispatch of practically all the available wind power while minimizing the costs of operation. The scheduled reserve has an economic value since it reduces the outage costs. In several electricity markets, reserve demand functions have been implemented to take into account the value of reserve in the market clearing process. These often take the form of a step-down function at the reserve requirement level, and as such they may not appropriately represent the reserve value. The value of reserve is impacted by the reliability, dynamic and stochastic characteristics of system components, the system operation policies, and the economic aspects such as the risk preferences of the demand. In this thesis, these aspects are taken into account to approximate the reserve value and construct reserve demand functions. Illustrative examples show that the demand functions constructed have similarities with those implemented in some markets.

  7. Reserve reporting from a banker's perspective

    International Nuclear Information System (INIS)

    Larson, B.O.

    1996-01-01

    A banker's perspective of oil and gas reserve reporting was presented. Topics chosen for discussion emphasized oil and gas lending, and the type of capital which is most relevant to the oil and gas industry. The concept of capital differentiation, potential worst case, and least specialization, were explained. An explanation of the reasons for the lender's different perspective on reserves was given. Methods that banks use to limit risk, and the role that reserve reports play in loan approvals were also reviewed

  8. Product line design

    Czech Academy of Sciences Publication Activity Database

    Anderson, S. P.; Celik, Levent

    2015-01-01

    Roč. 157, May (2015), s. 517-526 ISSN 0022-0531 Institutional support: RVO:67985998 Keywords : product line design * product differentiation * second-degree price discrimination Subject RIV: AH - Economics Impact factor: 1.097, year: 2015

  9. Illustrating the Euler Line.

    Science.gov (United States)

    Rubillo, James M.

    1987-01-01

    Euler's discovery about the centroid of a triangle trisecting the line segment joining its circumference to its orthocenter is discussed. An activity that will help students review fundamental concepts is included. (MNS)

  10. Kansas Electric Transmission Lines

    Data.gov (United States)

    Kansas Data Access and Support Center — This data set is a digital representation of the EletcircTransmission lines for the State of Kansas as maintained by the Kansas Corporation Commission. Data is...

  11. Veterans Crisis Line

    Data.gov (United States)

    Department of Veterans Affairs — The caring responders at the Veterans Crisis Line are specially trained and experienced in helping Veterans of all ages and circumstances. Some of the responders are...

  12. Electric Power Transmission Lines

    Data.gov (United States)

    Department of Homeland Security — Transmission Lines are the system of structures, wires, insulators and associated hardware that carry electric energy from one point to another in an electric power...

  13. When will fossil fuel reserves be diminished?

    International Nuclear Information System (INIS)

    Shafiee, Shahriar; Topal, Erkan

    2009-01-01

    Crude oil, coal and gas are the main resources for world energy supply. The size of fossil fuel reserves and the dilemma that 'when non-renewable energy will be diminished' is a fundamental and doubtful question that needs to be answered. This paper presents a new formula for calculating when fossil fuel reserves are likely to be depleted and develops an econometrics model to demonstrate the relationship between fossil fuel reserves and some main variables. The new formula is modified from the Klass model and thus assumes a continuous compound rate and computes fossil fuel reserve depletion times for oil, coal and gas of approximately 35, 107 and 37 years, respectively. This means that coal reserves are available up to 2112, and will be the only fossil fuel remaining after 2042. In the Econometrics model, the main exogenous variables affecting oil, coal and gas reserve trends are their consumption and respective prices between 1980 and 2006. The models for oil and gas reserves unexpectedly show a positive and significant relationship with consumption, while presenting a negative and significant relationship with price. The econometrics model for coal reserves, however, expectedly illustrates a negative and significant relationship with consumption and a positive and significant relationship with price. Consequently, huge reserves of coal and low-level coal prices in comparison to oil and gas make coal one of the main energy substitutions for oil and gas in the future, under the assumption of coal as a clean energy source. (author)

  14. Reservation system with graphical user interface

    KAUST Repository

    Mohamed, Mahmoud A. Abdelhamid

    2012-01-05

    Techniques for providing a reservation system are provided. The techniques include displaying a scalable visualization object, wherein the scalable visualization object comprises an expanded view element of the reservation system depicting information in connection with a selected interval of time and a compressed view element of the reservation system depicting information in connection with one or more additional intervals of time, maintaining a visual context between the expanded view and the compressed view within the visualization object, and enabling a user to switch between the expanded view and the compressed view to facilitate use of the reservation system.

  15. Reliability assessment of reserved water disposal with erodible fuse plug

    Directory of Open Access Journals (Sweden)

    Kosichenko Yuriy Mikhaylovich

    Full Text Available Water disposal constructions are one of the most responsible constructions of reservoir hydrosystem, that’s why the a lot of attention was always paid to the problems of estimating and providing their reliability and safety. The most important function of such objects is providing reliability and safety of other hydraulic constructions and economic assets in afterbay and water head. The authors offer estimation method for reliability and faultless performance of reserved water disposal with erodible fuse plug on low-head water development. In order to estimate the reliability of reserved water disposal with erodible fuse plug the Bayesian treatment was used. The calculation of diagnoses (states of reserved water disposal isoffered in case of diagnostic properties k 1 and k 2. One of the main demands placed onreserved water disposals is erosion of soil plug in case of flood discharge exeedance over the estimated frequency with the full opening of the waste sluice.

  16. Nasca Lines, Peru

    Science.gov (United States)

    2001-01-01

    The Nasca Lines are located in the Pampa region of Peru, the desolate plain of the Peruvian coast 400 km south of Lima. The Lines were first spotted when commercial airlines began flying across the Peruvian desert in the 1920's. Passengers reported seeing 'primitive landing strips' on the ground below. The Lines were made by removing the iron-oxide coated pebbles which cover the surface of the desert. When the gravel is removed, they contrast with the light color underneath. In this way the lines were drawn as furrows of a lighter color. On the pampa, south of the Nasca Lines, archaeologists have now uncovered the lost city of the line-builders, Cahuachi. It was built nearly two thousand years ago and was mysteriously abandoned 500 years later. This ASTER sub-image covers an area of 14 x 18 km, was acquired on December 22, 2000, and is located at 14.7 degrees south latitude and 75.1 degrees west longitude. The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

  17. Quantum anomalies in nodal line semimetals

    Science.gov (United States)

    Burkov, A. A.

    2018-04-01

    Topological semimetals are a new class of condensed matter systems with nontrivial electronic structure topology. Their unusual observable properties may often be understood in terms of quantum anomalies. In particular, Weyl and Dirac semimetals, which have point band-touching nodes, are characterized by the chiral anomaly, which leads to the Fermi arc surface states, anomalous Hall effect, negative longitudinal magnetoresistance, and planar Hall effect. In this paper, we explore analogous phenomena in nodal line semimetals. We demonstrate that such semimetals realize a three-dimensional analog of the parity anomaly, which is a known property of two-dimensional Dirac semimetals arising, for example, on the surface of a three-dimensional topological insulator. We relate one of the characteristic properties of nodal line semimetals, namely, the drumhead surface states, to this anomaly, and derive the field theory, which encodes the corresponding anomalous response.

  18. On the applicability of conventional transmission line theory within cavities

    Directory of Open Access Journals (Sweden)

    F. Gronwald

    2006-01-01

    Full Text Available We investigate whether or not conventional transmission line theory needs to be modified if transmission lines are considered that are located in a cavity rather than in free space. Our analysis is based on coupled Pocklington's equations that can be reduced to integral equations for the antenna mode and the transmission line mode. Under the usual assumptions of conventional transmission line theory these modes do approximately decouple within a cavity. As a result, cavity properties will primarily influence the antenna mode but not the transmission line mode.

  19. Emission-line spectra of QSOs and their redshifts

    International Nuclear Information System (INIS)

    Burbidge, E.M.

    1978-01-01

    A brief review of work on the emission-line spectra of QSOs is given. Data on radio-emitting and radio-quiet objects are discussed, with sections dealing with the lines that are observed, the distributions of red shifts obtained from the emission lines, and a selection of particular problems posed by current observations. These include a discussion of QSOs with atypical spectra, the Lyman/Balmer/Paschen relative line strengths, the abundances of the elements, correlations of observed properties, and gas flow within the emission-line region. (Auth.)

  20. Estimation of Uncertainles in Gas-Condensate Systems Reserves by Monte Carlo Simulation

    OpenAIRE

    Nagy Stanislaw; Siemek Jakub

    2004-01-01

    In the paper, an impact of improper condensate sampling on calculation of gas and condensate reserves of gas-condensate system is presented. The paper discusses probabilistic methods in reserves estimation (proven, possible, probable). The Peng-Robinson equation of state (EOS) has been used to calculations of phase properties. Sensitivity of CGR during recombination of stream process on liquid and gas reserves has been shown. The large error in estimation of condensate reserve has been obtain...

  1. 48 CFR 4.501 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false [Reserved] 4.501 Section 4.501 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Electronic Commerce in Contracting 4.501 [Reserved...

  2. 7 CFR 300.1 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false [Reserved] 300.1 Section 300.1 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INCORPORATION BY REFERENCE § 300.1 [Reserved...

  3. 7 CFR 305.4 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false [Reserved] 305.4 Section 305.4 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE PHYTOSANITARY TREATMENTS § 305.4 [Reserved...

  4. 50 CFR 216.42 - Photography. [Reserved

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Photography. [Reserved] 216.42 Section 216.42 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC... MAMMALS Special Exceptions § 216.42 Photography. [Reserved] ...

  5. 9 CFR 73.1a - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false [Reserved] 73.1a Section 73.1a Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS SCABIES IN CATTLE § 73.1a [Reserved] ...

  6. 12 CFR 614.4710 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false [Reserved] 614.4710 Section 614.4710 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LOAN POLICIES AND OPERATIONS Banks for Cooperatives and Agricultural Credit Banks Financing International Trade § 614.4710 [Reserved] ...

  7. 40 CFR 406.43 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 406.43 Section 406.43 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Bulgur Wheat Flour Milling Subcategory § 406.43 [Reserved] ...

  8. 40 CFR 406.23 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 406.23 Section 406.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Corn Dry Milling Subcategory § 406.23 [Reserved] ...

  9. 40 CFR 406.13 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 406.13 Section 406.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Corn Wet Milling Subcategory § 406.13 [Reserved] ...

  10. 24 CFR 891.855 - Replacement reserves.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserves. 891.855... § 891.855 Replacement reserves. (a) The mixed-finance owner shall establish and maintain a replacement... the funds will be used to pay for capital replacement costs for the Section 202 or 811 supportive...

  11. 22 CFR 40.69 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false [Reserved] 40.69 Section 40.69 Foreign Relations DEPARTMENT OF STATE VISAS REGULATIONS PERTAINING TO BOTH NONIMMIGRANTS AND IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Illegal Entrants and Immigration Violators § 40.69 [Reserved] ...

  12. Body reserves in intra-African migrants

    NARCIS (Netherlands)

    Nwaogu, Chima; Cresswell, Will

    Avian migration has been shown to be a life history strategy for surviving environmental resource variability, but it requires increased body reserves for long distance flight. Fat reserves make excellent energy stores for barrier crossing, whereas proteins generate less energy for the same mass of

  13. 21 CFR 211.170 - Reserve samples.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Reserve samples. 211.170 Section 211.170 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL... of deterioration unless visual examination would affect the integrity of the reserve sample. Any...

  14. 8 CFR 325.1 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false [Reserved] 325.1 Section 325.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY NATIONALITY REGULATIONS NATIONALS BUT NOT CITIZENS OF THE UNITED STATES; RESIDENCE WITHIN OUTLYING POSSESSIONS § 325.1 [Reserved] ...

  15. 30 CFR 253.44 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false [Reserved] 253.44 Section 253.44 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Requirements for Submitting OSFR Information § 253.44 [Reserved] ...

  16. 14 CFR 33.13 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false [Reserved] 33.13 Section 33.13 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; General § 33.13 [Reserved] ...

  17. 14 CFR 35.13 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false [Reserved] 35.13 Section 35.13 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: PROPELLERS Design and Construction § 35.13 [Reserved] ...

  18. 14 CFR 35.11 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false [Reserved] 35.11 Section 35.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: PROPELLERS Design and Construction § 35.11 [Reserved] ...

  19. Reserve selection using nonlinear species distribution models.

    Science.gov (United States)

    Moilanen, Atte

    2005-06-01

    Reserve design is concerned with optimal selection of sites for new conservation areas. Spatial reserve design explicitly considers the spatial pattern of the proposed reserve network and the effects of that pattern on reserve cost and/or ability to maintain species there. The vast majority of reserve selection formulations have assumed a linear problem structure, which effectively means that the biological value of a potential reserve site does not depend on the pattern of selected cells. However, spatial population dynamics and autocorrelation cause the biological values of neighboring sites to be interdependent. Habitat degradation may have indirect negative effects on biodiversity in areas neighboring the degraded site as a result of, for example, negative edge effects or lower permeability for animal movement. In this study, I present a formulation and a spatial optimization algorithm for nonlinear reserve selection problems in grid-based landscapes that accounts for interdependent site values. The method is demonstrated using habitat maps and nonlinear habitat models for threatened birds in the Netherlands, and it is shown that near-optimal solutions are found for regions consisting of up to hundreds of thousands grid cells, a landscape size much larger than those commonly attempted even with linear reserve selection formulations.

  20. 7 CFR 1709.2 Policy. - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false [Reserved] 1709.2 Policy. Section 1709.2 Policy. Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES General Requirements § 1709.2 Policy. [Reserved] ...

  1. 7 CFR 1709.202 Policy. - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false [Reserved] 1709.202 Policy. Section 1709.202 Policy... AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES Bulk Fuel Revolving Fund Grant Program § 1709.202 Policy. [Reserved] ...

  2. 7 CFR 3560.65 - Reserve account.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Reserve account. 3560.65 Section 3560.65 Agriculture... DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Direct Loan and Grant Origination § 3560.65 Reserve account... account that meets requirements of § 3560.306. At a minimum, the borrower must agree to make monthly...

  3. 21 CFR 720.5 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false [Reserved] 720.5 Section 720.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) COSMETICS VOLUNTARY FILING OF COSMETIC PRODUCT INGREDIENT COMPOSITION STATEMENTS § 720.5 [Reserved] ...

  4. 39 CFR 111.5 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false [Reserved] 111.5 Section 111.5 Postal Service UNITED STATES POSTAL SERVICE POST OFFICE SERVICES [DOMESTIC MAIL] GENERAL INFORMATION ON POSTAL SERVICE § 111.5 [Reserved] ...

  5. 75 FR 44067 - Conservation Reserve Program

    Science.gov (United States)

    2010-07-28

    ... amending the Conservation Reserve Program (CRP) regulations to implement provisions of the Food, Conservation, and Energy Act of 2008 (the 2008 Farm Bill). The 2008 Farm Bill generally extends the existing... Commodity Credit Corporation 7 CFR Part 1410 RIN 0560-AH80 Conservation Reserve Program AGENCY: Commodity...

  6. 7 CFR 1780.8 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1780.8 Section 1780.8 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE LOANS AND GRANTS General Policies and Requirements § 1780.8 [Reserved] ...

  7. 7 CFR 1779.79 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1779.79 Section 1779.79 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.79 [Reserved] ...

  8. 7 CFR 1780.5 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1780.5 Section 1780.5 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE LOANS AND GRANTS General Policies and Requirements § 1780.5 [Reserved] ...

  9. 7 CFR 1779.82 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1779.82 Section 1779.82 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.82 [Reserved] ...

  10. 7 CFR 1779.74 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1779.74 Section 1779.74 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.74 [Reserved] ...

  11. 7 CFR 1780.12 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1780.12 Section 1780.12 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE LOANS AND GRANTS General Policies and Requirements § 1780.12 [Reserved] ...

  12. 7 CFR 1779.26 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1779.26 Section 1779.26 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.26 [Reserved] ...

  13. 20 CFR 410.394 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false [Reserved] 410.394 Section 410.394 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and Dependency § 410.394 [Reserved] ...

  14. 40 CFR 26.1124 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false [Reserved] 26.1124 Section 26.1124 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical...-nursing Adults § 26.1124 [Reserved] ...

  15. 34 CFR 97.121 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false [Reserved] 97.121 Section 97.121 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.121 [Reserved] ...

  16. Running on Empty? The Compensatory Reserve Index

    Science.gov (United States)

    2013-12-01

    and HR,31 more blood pressure oscillations,32 and greater vasoconstrictor reserve,33 compared with low-tolerant individuals. By leveraging recent... vasoconstrictor reserves. Clin Auton Res. 2012; 22:123Y130. 32. Rickards CA, Ryan KL, Cooke WH, Convertino VA. Tolerance to central hypovolemia: the

  17. 77 FR 66980 - Federal Reserve Bank Services

    Science.gov (United States)

    2012-11-08

    ... earn net income of $15.3 million, compared with the target of $9.1 million. While the check service and... upgrades, and increase product revenue. 4. 2013 Pricing--The following summarizes the Reserve Banks... the office closed. The Reserve Banks also will introduce incentive pricing for depository institutions...

  18. 15 CFR 2003.3 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false [Reserved] 2003.3 Section 2003.3 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS OF TRADE POLICY STAFF COMMITTEE § 2003.3 [Reserved] ...

  19. The Economics of NASA Mission Cost Reserves

    Science.gov (United States)

    Whitley, Sally; Shinn, Stephen

    2012-01-01

    Increases in NASA mission costs are well-noted but not well-understood, and there is little evidence that they are decreasing in frequency or amount over time. The need to control spending has led to analysis of the causes and magnitude of historical mission overruns, and many program control efforts are being implemented to attempt to prevent or mitigate the problem (NPR 7120). However, cost overruns have not abated, and while some direct causes of increased spending may be obvious (requirements creep, launch delays, directed changes, etc.), the underlying impetus to spend past the original budget may be more subtle. Gaining better insight into the causes of cost overruns will help NASA and its contracting organizations to avoid .them. This paper hypothesizes that one cause of NASA mission cost overruns is that the availability of reserves gives project team members an incentive to make decisions and behave in ways that increase costs. We theorize that the presence of reserves is a contributing factor to cost overruns because it causes organizations to use their funds less efficiently or to control spending less effectively. We draw a comparison to the insurance industry concept of moral hazard, the phenomenon that the presence of insurance causes insureds to have more frequent and higher insurance losses, and we attempt to apply actuarial techniques to quantifY the increase in the expected cost of a mission due to the availability of reserves. We create a theoretical model of reserve spending motivation by defining a variable ReserveSpending as a function of total reserves. This function has a positive slope; for every dollar of reserves available, there is a positive probability of spending it. Finally, the function should be concave down; the probability of spending each incremental dollar of reserves decreases progressively. We test the model against available NASA CADRe data by examining missions with reserve dollars initially available and testing whether

  20. Simulation of wind turbine wakes using the actuator line technique.

    Science.gov (United States)

    Sørensen, Jens N; Mikkelsen, Robert F; Henningson, Dan S; Ivanell, Stefan; Sarmast, Sasan; Andersen, Søren J

    2015-02-28

    The actuator line technique was introduced as a numerical tool to be employed in combination with large eddy simulations to enable the study of wakes and wake interaction in wind farms. The technique is today largely used for studying basic features of wakes as well as for making performance predictions of wind farms. In this paper, we give a short introduction to the wake problem and the actuator line methodology and present a study in which the technique is employed to determine the near-wake properties of wind turbines. The presented results include a comparison of experimental results of the wake characteristics of the flow around a three-bladed model wind turbine, the development of a simple analytical formula for determining the near-wake length behind a wind turbine and a detailed investigation of wake structures based on proper orthogonal decomposition analysis of numerically generated snapshots of the wake. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  1. Impact of HVOTLs on Residential Property Rental Values in High ...

    African Journals Online (AJOL)

    The study encouraged the use of buried armour cables instead of overhead power-lines in future and the strict enforcement of ROWs within Lagos metropolis where power-lines already exist, in a bid to abate the effect of power line on property investments. Keywords: HVOTLs, Power-line, Residential, Property, Rental ...

  2. 76 FR 64250 - Reserve Requirements of Depository Institutions: Reserves Simplification and Private Sector...

    Science.gov (United States)

    2011-10-18

    ... D; Docket No. R-1433] RIN No. 7100 AD 83 Reserve Requirements of Depository Institutions: Reserves Simplification and Private Sector Adjustment Factor AGENCY: Board of Governors of the Federal Reserve System... public comment on proposed amendments to Regulation D, Reserve Requirements of Depository Institutions...

  3. Second line therapy in malignant pleural mesothelioma: A systematic review.

    Science.gov (United States)

    Buikhuisen, Wieneke A; Hiddinga, Birgitta I; Baas, Paul; van Meerbeeck, Jan P

    2015-09-01

    After the implementation of standard first line chemotherapy with platinum and antifolates in pleural mesothelioma, patients are confronted with a need for second line treatment at relapse or progression. We conducted a systematic review of the literature for the activity, effectiveness and toxicity of second line treatment. The results are presented according to the class of drugs: chemotherapy and targeted or biological agent. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  4. Malaysian meteoric water line

    International Nuclear Information System (INIS)

    Md Shahid Ayub

    2006-01-01

    The quest for Malaysian meteoric water line began in 1981 when environmental isotope hydrology was introduced. In the 1980, and with the establishment of three stations at Pengkalan Chepa, Kepala Batas and Kuah, the Malaysian Meteoric Water Line acquired then was δD = 8δ 18 O + 12.68. With the addition of another four stations, by the end of 1990s, the Malaysian Meteoric Water Line for the decade was established as δD = 8 δ 18 O + 11.76. Taking the overall result between 1980 and mid 2000s the Malaysian Meteoric Water Line was established as δD = 8 δ 18 O + 13.255 and the weighted mean precipitation is (-7.64, -46.74). In establishing this meteoric water line it was observed that the higher altitude station manifested poorer stable isotopes content as compared to lower altitude station. It was also observed that as the amount of rain increased, the stable isotopes content would decrease and vice versa. The effect is reversed when the amount is due to monsoon rains and tropical storms. (Author)

  5. Beam line to S155

    CERN Multimedia

    1977-01-01

    The experiment S155 was designed by the Orsay (CSNM-CNRS) Collaboration to observe the properties of exotic light nuclei. It was installed in the PS neutrino tunnel. The photo shows a mass spectrometer (in the background) on line with the PS proton beam which arrives (bottom, right) from the fast extraction FE74. Roger Fergeau stands on the left. The alkaline isotopes produced in the carbon-uranium target heated at 2000°C were swiftly extracted, mass separated, and brought to a detector behind the shielding. Sodium 34 (11 protons and 23 neutrons) was observed and its half-life of only 5 ms was measured. The excited levels 2+ of Magnesium 30 and Magnesium 32 (Sodium descendants) were localised, and the magic number 20 was found to vanish. Thus, the discovery made earlier for Sodium 30 and Sodium 32, with the same apparatus, was confirmed. (See also photo 7706511.)

  6. Cognitive reserve and appraisal in multiple sclerosis.

    Science.gov (United States)

    Schwartz, Carolyn E; Snook, Erin; Quaranto, Brian; Benedict, Ralph H B; Rapkin, Bruce D; Vollmer, Timothy

    2013-01-01

    Cognitive appraisal processes underlying self-report affect the interpretation of patient-reported outcomes. These processes are relevant to resilience and adaptability, and may relate to how cognitive reserve protects against disability in multiple sclerosis (MS). To describe how passive and active indicators of cognitive reserve relate to QOL appraisal processes in MS. Cross-sectional data (n=860) were drawn from the North American Research Committee on MS (NARCOMS) Registry, from whom additional survey data were collected. Cognitive reserve was measured using the Stern and Sole-Padulles measures. Using the quality of life appraisal profile (QOLAP), we assessed how MS patients conceptualize their experiences and how that impacts how they report their quality of life. Multivariate analysis of variance was used to compare groups within sets of appraisal parameters, and t-tests or chi-square tests were used to compare mean item responses within appraisal parameters for continuous or dichotomous variables, respectively. People high in passive or active reserve report different conceptualizations of QOL, different types of goals, and considering different types of experiences and standards of comparison in responding to QOL questionnaires, as compared to low-reserve individuals. Although item response patterns were slightly different between passive and active indicators, they generally reflect a tendency in high-reserve individuals to emphasize the positive, focus on aspects of their life that are more controllable, and less based in fantasy. MS patients high in cognitive reserve differ in their cognitive appraisals from their low reserve counterparts. These appraisal metrics may predict disease course and other important clinical outcomes in MS patients. Copyright © 2012 Elsevier B.V. All rights reserved.

  7. Strategic Petroleum Reserve: Annual/quarterly report

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-16

    Section 165 of the Energy Policy and Conservation Act (Public Law 94-163), as amended, requires the Secretary of Energy to submit annual and quarterly reports to the President and the Congress on activities of the Strategic Petroleum Reserve. This report combines the fourth quarter 1993 Quarterly Report with the 1993 Annual Report. Key activities described include appropriations; life extension planning; expansion planning; Strategic Petroleum Reserve oil acquisition; the oil stabilization program; and the refined petroleum product reserve test programs. Sections of this report also describe the program mission; the storage facility development program; environmental compliance; budget and finance; and drawdown and distribution.

  8. 40 CFR 94.511 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false 94.511 Section 94.511 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM MARINE COMPRESSION-IGNITION ENGINES Manufacturer Production Line Testing Programs § 94.511 ...

  9. H Emission Line Morphologies in Markarian Starburst Galaxies

    Indian Academy of Sciences (India)

    We present broad band and narrow band H emission line images of a sample of optically selected starburst galaxies from the Markarian lists. The emission line morphology is studied and global properties like luminosities, equivalent widths and star formation rates are derived. The radial distribution of H flux and the ...

  10. Singular point detection algorithm based on the transition line of the fingerprint orientation image

    CSIR Research Space (South Africa)

    Mathekga, ME

    2009-11-01

    Full Text Available A new algorithm for identifying and locating singular points on a fingerprint image is presented. This algorithm is based on properties of the fingerprint orientation image, including a feature defined as a transition line. The transition line...

  11. Sprayed concrete linings

    Energy Technology Data Exchange (ETDEWEB)

    Hindle, D.

    1999-12-01

    Sprayed concrete, or shotcrete, was invented in the 1920s for preserving dinosaur skeletons and was used underground initially in coalmines for the preservation and fine proofing of timber supports. Its use as a support lining in rock tunnelling was developed in the 1950s and 60s. The article surveys equipment available from major manufacturers and suppliers of concrete spraying equipment (Aliva, Cifa, GIA, Industri, Ingersoll Rand, etc.), specialist cement and additive manufacturers (Castle, Cement, Moria Carbotech). manufacturers of lattice girders and fibre reinforcement, and manufacturers of instrumentation for tunnel linings. 5 tabs., 9 photos.

  12. Operational Army Reserve Implications for Organizational Health

    National Research Council Canada - National Science Library

    Dahms, Jonathan A

    2007-01-01

    The Army Reserve has been in a constant state of mobilization since 1995 with the advent of the Bosnia crisis and the pace of mobilization increased exponentially after the terrorist attacks of September 11, 2001...

  13. Communicating marine reserve science to diverse audiences

    Science.gov (United States)

    Grorud-Colvert, Kirsten; Lester, Sarah E.; Airamé, Satie; Neeley, Elizabeth; Gaines, Steven D.

    2010-01-01

    As human impacts cause ecosystem-wide changes in the oceans, the need to protect and restore marine resources has led to increasing calls for and establishment of marine reserves. Scientific information about marine reserves has multiplied over the last decade, providing useful knowledge about this tool for resource users, managers, policy makers, and the general public. This information must be conveyed to nonscientists in a nontechnical, credible, and neutral format, but most scientists are not trained to communicate in this style or to develop effective strategies for sharing their scientific knowledge. Here, we present a case study from California, in which communicating scientific information during the process to establish marine reserves in the Channel Islands and along the California mainland coast expanded into an international communication effort. We discuss how to develop a strategy for communicating marine reserve science to diverse audiences and highlight the influence that effective science communication can have in discussions about marine management. PMID:20427745

  14. 48 CFR 9904.404-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.404-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.404-10 [Reserved] ...

  15. 48 CFR 9904.401-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.401-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.401-10 [Reserved] ...

  16. 48 CFR 9904.400 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.400 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.400 [Reserved] ...

  17. 48 CFR 9904.402-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.402-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.402-10 [Reserved] ...

  18. 48 CFR 9904.405-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.405-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.405-10 [Reserved] ...

  19. 48 CFR 9904.407-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.407-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.407-10 [Reserved] ...

  20. 48 CFR 9904.408-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.408-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.408-10 [Reserved] ...

  1. 48 CFR 9904.406-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.406-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.406-10 [Reserved] ...

  2. 48 CFR 9904.403-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.403-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.403-10 [Reserved] ...

  3. 10 CFR 51.110 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) Rulemaking § 51.110 [Reserved] Public Notice of and Access to Environmental Documents ...

  4. U.S. Federal Reserve Systems

    Data.gov (United States)

    Department of Homeland Security — This dataset is comprised of forty-five entities that are part of the United States Federal Reserve System according to the United States Department of Treasury. The...

  5. Communicating marine reserve science to diverse audiences.

    Science.gov (United States)

    Grorud-Colvert, Kirsten; Lester, Sarah E; Airamé, Satie; Neeley, Elizabeth; Gaines, Steven D

    2010-10-26

    As human impacts cause ecosystem-wide changes in the oceans, the need to protect and restore marine resources has led to increasing calls for and establishment of marine reserves. Scientific information about marine reserves has multiplied over the last decade, providing useful knowledge about this tool for resource users, managers, policy makers, and the general public. This information must be conveyed to nonscientists in a nontechnical, credible, and neutral format, but most scientists are not trained to communicate in this style or to develop effective strategies for sharing their scientific knowledge. Here, we present a case study from California, in which communicating scientific information during the process to establish marine reserves in the Channel Islands and along the California mainland coast expanded into an international communication effort. We discuss how to develop a strategy for communicating marine reserve science to diverse audiences and highlight the influence that effective science communication can have in discussions about marine management.

  6. The Economics of NASA Mission Cost Reserves

    Science.gov (United States)

    Whitley, Sally; Shinn, Stephen

    2012-01-01

    Increases in NASA mission costs have led to analysis of the causes and magnitude of historical mission overruns as well as mitigation and prevention attempts. This paper hypothesizes that one cause is that the availability of reserves may reduce incentives to control costs. We draw a comparison to the insurance concept of moral hazard, and we use actuarial techniques to better understand the increase in mission costs due to the availability of reserves. NASA's CADRe database provided the data against which we tested our hypothesis and discovered that there is correlation between the amount of available reserves and project overruns, particularly for mission hardware cost increases. We address the question of how to prevent reserves from increasing mission spending without increasing cost risk to projects.

  7. 40 CFR 63.131 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for Organic Hazardous Air Pollutants From the Synthetic Organic Chemical Manufacturing Industry for Process Vents, Storage Vessels, Transfer Operations, and Wastewater § 63.131 [Reserved] ...

  8. Reserves and cash flows under stochastic retirement

    DEFF Research Database (Denmark)

    Gad, Kamille Sofie Tågholt; Nielsen, Jeppe Woetmann

    2016-01-01

    and the guarantees provided. Stochastic retirement creates a need to rethink the construction of disability products for high ages and ways to handle this are discussed. We show how to calculate market reserves and how to use modified transition probabilities to calculate expected cash flows without significantly...... more complexity than in the traditional model. At last, we demonstrate the impact of stochastic retirement on market reserves and expected cash flow in numerical examples....

  9. Cognitive reserve in ageing and Alzheimer's disease

    OpenAIRE

    Stern, Yaakov

    2012-01-01

    The concept of reserve accounts for individual differences in susceptibility to age-related brain changes or Alzheimer's disease-related pathology. There is evidence that some people can tolerate more of these changes than others and still maintain function. Epidemiologic studies suggest that lifetime exposures including educational and occupational attainment, and leisure activities in late life, can increase this reserve. For example, there is a reduced risk of developing Alzheimer's diseas...

  10. Reserve Component Programs, Fiscal Year 1991

    Science.gov (United States)

    1992-02-28

    utilizing WMrcha’t Marine Academy gr , ,ates and Naval Reserve Officer Training Course S’(NROTC)/Student Incentive Progrim (SIP) graduates from state...personnel gr , atly enhances the mobilization and combat readiness of the Total Force. Several new medical programs were implemented by the Reserve components...Defense Force Chief of Joint Staff, Defense Command * Mendez, Honorable Enrique Jr., M.D. Norway Assistant Secretary of Defense for Health Affairs

  11. Exploration report in mining reserve XIV

    International Nuclear Information System (INIS)

    Spoturno Pioppo, J.; Lara Vigil, P.

    1991-01-01

    This report has been referred to the antecedents and works developed in the mining Reservation XIV. This Reservation, covered a 1900 km2 surface, involving the aerial photography Valentines Cerro Chato, Chileno, Rossel y Rius, Sarandi del Yi and Cuchilla del Pescado. It has been reduced this area to western part of the aerial phothograpy Pavas, releasing other areas such as Chileno, Rossel y Rius, Cuchilla del Pescado y Cerro Chato. Finally, gold, sulphures, pirite and carbonates iron oxides findings have been found.

  12. Unanswered Quibbles with Fractional Reserve Free Banking

    OpenAIRE

    Bagus, Philipp; Howden, David

    2011-01-01

    In this article we reply to George Selgin’s counterarguments to our article “Fractional Reserve Free Banking: Some Quibbles”. Selgin regards holding cash as saving while we focus on the real savings necessary to maintain investment projects. Real savings are unconsumed real income. Variations in real savings are not necessarily equal to variations in cash holdings. We show that a coordinated credit expansion in a fractional reserve free banking (FRFB) system is possible and that precautionary...

  13. Natural radioactivity as indicator of petroleum reserves

    International Nuclear Information System (INIS)

    Palacios, T.; Viloriab, L.; Sajo Bohusa, K.; Gomez, A.

    2001-01-01

    The possibilities of the measurement method of Radon emanation from the ground, using passive detectors, to identify oil-saturated beds in reserves or well-known deposit was evaluated in the North part of the Orinoco river and in some areas of Zulia Sate, Venezuela. The existence of Negative anomalies of radon emanation in regions of proven petroleum reserves was shown. The Space variability of emanated Radon concentration from the ground was measured and maps of three-dimensional contour curves applying different surface models were obtained, which allowed to locate the anomalies of radon emanation and to compare them with the location of reserves reported by other methods. In both regions it was obtained that the area having the lowest radon value is surrounded by an annular region of high radon values, being able to identify a locally decreased emanation over petroleum reserves as compared to the surroundings. The cause of such anomalies is not identified but they can provide useful information for locating the deeply buried oil reserves. Both regions showed a decrease in gamma activity and in upward flow of gases CH4 and C02 over the geologic structures which contain petroleum reserves Underneath. An applicable experimental routine was proposed to other regions. We conclude that the method of etched track detection can be useful in recognizing the subsurface oil-bearing structures and the technique is relatively simple and inexpensive

  14. Bike Map Lines

    Data.gov (United States)

    Town of Chapel Hill, North Carolina — Chapel Hill Bike Map Lines from KMZ file.This data came from the wiki comment board for the public, not an “official map” showing the Town of Chapel Hill's plans or...

  15. Product line design

    Czech Academy of Sciences Publication Activity Database

    Anderson, S. P.; Celik, Levent

    2015-01-01

    Roč. 157, May (2015), s. 517-526 ISSN 0022-0531 R&D Projects: GA ČR(CZ) GA15-22540S Institutional support: PRVOUK-P23 Keywords : product line design * product differentiation * second-degree price discrimination Subject RIV: AH - Economics Impact factor: 1.097, year: 2015

  16. Defining line replaceable units

    NARCIS (Netherlands)

    Parada Puig, J.E.; Basten, Robertus Johannes Ida

    2015-01-01

    Defective capital assets may be quickly restored to their operational condition by replacing the item that has failed. The item that is replaced is called the Line Replaceable Unit (LRU), and the so-called LRU definition problem is the problem of deciding on which item to replace upon each type of

  17. America's Assembly Line

    DEFF Research Database (Denmark)

    Nye, David Edwin

    A social history of the assembly line, invented in 1913. Both praised as a boon to consumers and as a curse for workers, it has been satirized, imitated, and celebrated for 100 years. It has inspired fiction, comedy, cafeteria layouts, and suburban housing. It transformed industrial labor...

  18. Developing Green Line Products

    DEFF Research Database (Denmark)

    Muñoz-Marin, Ana Maria; Lassen, Astrid Heidemann; Poulsen, Søren Bolvig

    2011-01-01

    This publication is based on the Master thesis “User-driven ecoinnovation process: Towards the implementation of the Green product line at JELD-WEN” written by Ana Maria Muñoz-Marin as her Graduation Project for the MSc. Global Innovation Management degree. The company-based experiment was carried...

  19. Drawing the Line

    DEFF Research Database (Denmark)

    Holm, Isak Winkel

    2016-01-01

    of judgement that distinguishes between the inside and outside of a political community, between citizens and zombies. Second, the chapter focuses on the rhetorics applied to draw the line between rights-bearers and the rightless. ‘Prophetic’ speech, echoing the language of the Old Testament prophets, is vital...

  20. LEAR: antiproton extraction lines

    CERN Multimedia

    Photographic Service

    1992-01-01

    Antiprotons, decelerated in LEAR to a momentum of 100 MeV/c (kinetic energy of 5.3 MeV), were delivered to the experiments in an "Ultra-Slow Extraction", dispensing some 1E9 antiprotons over times counted in hours. Beam-splitters and a multitude of beam-lines allowed several users to be supplied simultaneously.

  1. K-line photometry

    International Nuclear Information System (INIS)

    Henry, R.C.

    1979-01-01

    A brief review is given of more than a decade of work involving measurement of the strength of the K line of calcium in A-type stars. The effects of interstellar reddening are reexamined, and an improved estimate for the range in calcium abundance among field stars is obtained. (Auth.)

  2. Subjective poverty line definitions

    NARCIS (Netherlands)

    J. Flik; B.M.S. van Praag (Bernard)

    1991-01-01

    textabstractIn this paper we will deal with definitions of subjective poverty lines. To measure a poverty threshold value in terms of household income, which separates the poor from the non-poor, we take into account the opinions of all people in society. Three subjective methods will be discussed

  3. Establishment and characterization of fetal and maternal mesenchymal stem/stromal cell lines from the human term placenta.

    Science.gov (United States)

    Qin, Sharon Q; Kusuma, Gina D; Al-Sowayan, Batla; Pace, Rishika A; Isenmann, Sandra; Pertile, Mark D; Gronthos, Stan; Abumaree, Mohamed H; Brennecke, Shaun P; Kalionis, Bill

    2016-03-01

    Human placental mesenchymal stem/stromal cells (MSC) are an attractive source of MSC with great therapeutic potential. However, primary MSC are difficult to study in vitro due to their limited lifespan and patient-to-patient variation. Fetal and maternal MSC were prepared from cells of the chorionic and basal plates of the placenta, respectively. Fetal and maternal MSC were transduced with the human telomerase reverse transcriptase (hTERT). Conventional stem cell assays assessed the MSC characteristics of the cell lines. Functional assays for cell proliferation, cell migration and ability to form colonies in soft agar were used to assess the whether transduced cells retained properties of primary MSC. Fetal chorionic and maternal MSC were successfully transduced with hTERT to create the cell lines CMSC29 and DMSC23 respectively. The lifespans of CMSC29 and DMSC23 were extended in cell culture. Both cell lines retained important MSC characteristics including cell surface marker expression and multipotent differentiation potential. Neither of the cell lines was tumourigenic in vitro. Gene expression differences were observed between CMSC29 and DMSC23 cells and their corresponding parent, primary MSC. Both cell lines show similar migration potential to their corresponding primary, parent MSC. The data show that transduced MSC retained important functional properties of the primary MSC. There were gene expression and functional differences between cell lines CMSC29 and DMSC23 that reflect their different tissue microenvironments of the parent, primary MSC. CMSC29 and DMSC23 cell lines could be useful tools for optimisation and functional studies of MSC. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. On-line and off-line assessment of metacognition

    Directory of Open Access Journals (Sweden)

    Seda Saraç

    2012-03-01

    Full Text Available he study investigates the interrelationships between different on-line and off-line measures for assessing metacognition. The participants were 47 fifth grade elementary students. Metacognition was assessed through two off-line and two on-line measures. The off-line measures consisted of a teacher rating scale and a self-report questionnaire. The on-line measures were thinking aloud protocols and accuracy ratings of text comprehension. The results showed positive significant correlation between data from two off-line measures and negative significant correlation between data from two on-line measures. The off-line metacognitive measures had non-significant correlations with all on-line measures. Principal Component Analysis, performed on four metacognitive measures, yielded a two-factor solution and this two-factor solution accounted for 71.5 % of the sample variance. The data from two off-line measures loaded on the first component with a variance proportion of 38.6 % and the data from two on-line measures loaded on the second component with a variance proportion of 32.9%. The findings of the study showed that metacognitive processes form a complex structure that needs to be assessed using various methods. However, in the multi-method studies, using on-line and off-line measures together will be appropriate rather than using only on-line measures or only off-line measures.

  5. Does cognitive reserve shape cognitive decline?

    Science.gov (United States)

    Marmot, Michael G; Glymour, Maria; Sabia, Séverine; Kivimäki, Mika; Dugravot, Aline

    2011-01-01

    Objectives Cognitive reserve is associated with a lower risk of dementia but the extent to which it shapes cognitive aging trajectories remains unclear. Our objective is to examine the impact of three markers of reserve from different points in the lifecourse on cognitive function and decline in late adulthood. Methods Data are from 5234 men and 2220 women, mean age 56 years (standard deviation=6) at baseline, from the Whitehall II cohort study. Memory, reasoning, vocabulary, phonemic and semantic fluency were assessed three times over 10 years. Linear mixed models were used to assess the association between markers of reserve (height, education, and occupation) and cognitive decline, using the 5 cognitive tests and a global cognitive score composed of these tests. Results All three reserve measures were associated with baseline cognitive function, with strongest associations with occupation and the weakest with height. All cognitive functions except vocabulary declined over the 10 year follow-up period. On the global cognitive test, there was greater decline in the high occupation group (−0.27; 95% confidence interval (CI): −0.28, −0.26) compared to the intermediate (−0.23; 95% CI: −0.25, −0.22) and low groups (−0.21; 95% CI: −0.24, −0.19); p=0.001. The decline in reserve groups defined by education (p=0.82) and height (p=0.55) was similar. Interpretation Cognitive performance over the adult lifecourse was remarkably higher in the high reserve groups. However, rate of cognitive decline did not differ between reserve groups except occupation where there was some evidence of greater decline in the high occupation group. PMID:21563209

  6. OPINIONS ON INTERNATIONAL RESERVES MANAGEMENT - POST CRISIS

    Directory of Open Access Journals (Sweden)

    MERCEA (HANDRO PATRICIA AMALIA

    2017-11-01

    Full Text Available The recent crisis demonstrated once again the importance of maintaining an adequate level of the international reserves as part of the defense of a country against the shocks internationally transmitted. Liquidity buffers aided the good functioning of financial systems, and allowed countries to cope with sudden foreign capital stops or to manage massive outflows without facing a costly crisis. This logic has been strengthened in the context of the crisis from 2008, when countries with lots of reserves, such as China or Brazil, came through better than those with lower liquid assets. Economists have argued that developing countries need reserves mainly to cover urgent imports and short-term debts. The current level of global reserves far exceeds this traditional postulate. In this context, it is necessary to rethink the adequacy of the level of constituting the reserves portfolio. The dominance of the dollar as a reserve currency, another important feature of the current reserves portfolio, makes the holders become vulnerable to the monetary policy of FED. A greater flexibility of the currency will also be needed. The often called the “trilemma” of international economics dictates: when capital is mobile, countries must choose between fixing their currencies and controlling their domestic monetary conditions. They cannot do both. The domestic currency inflexibility will ultimately lead to asset bubbles and inflation. The pressure of capital flows will depend on the prospects of rich economies, especially America’s. The increment of emerging economies availability to allow the exchange rate to move will depend on what China does - and China may remain forever linked to the dollar. The emergence of a global currency that constitute a genuine means of exchange or the use of cross-border multifaceted cash pools common to IMF members would reduce systemic risks. International regulations for countries with persistent trade surpluses could be a

  7. Automated in-line mixing system for large scale production of chitosan-based polyplexes.

    Science.gov (United States)

    Tavakoli Naeini, Ashkan; Soliman, Ousamah Younoss; Alameh, Mohamad Gabriel; Lavertu, Marc; Buschmann, Michael D

    2017-08-15

    Chitosan (CS)-based polyplexes are efficient non-viral gene delivery systems that are most commonly prepared by manual mixing. However, manual mixing is not only poorly controlled but also restricted to relatively small preparation volumes, limiting clinical applications. In order to overcome these drawbacks and to produce clinical quantities of CS-based polyplexes, a fully automated in-line mixing platform was developed for production of large batches of small-size and homogeneous CS-based polyplexes. Operational conditions to produce small-sized homogeneous polyplexes were identified. Increasing mixing concentrations of CS and nucleic acid was directly associated with an increase in size and polydispersity of both CS/pDNA and CS/siRNA polyplexes. We also found that although the speed of mixing has a negligible impact on the properties of CS/pDNA polyplexes, the size and polydispersity of CS/siRNA polyplexes are strongly influenced by the mixing speed: the higher the speed, the smaller the size and polydispersity. While in-line and manual CS/pDNA polyplexes had similar size and PDI, CS/siRNA polyplexes were smaller and more homogenous when prepared in-line in the non-laminar flow regime compared to manual method. Finally, we found that in-line mixed CS/siRNA polyplexes have equivalent or higher silencing efficiency of ApoB in HepG2 cells, compared to manually prepared polyplexes. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Design of back-streaming white neutron beam line at CSNS.

    Science.gov (United States)

    Zhang, L Y; Jing, H T; Tang, J Y; Li, Q; Ruan, X C; Ren, J; Ning, C J; Yu, Y J; Tan, Z X; Wang, P C; He, Y C; Wang, X Q

    2018-02-01

    A white neutron beam line using back-streaming neutrons from the spallation target is under construction at China Spallation Neutron Source (CSNS). Different spectrometers, to be installed in the so-called Back-n beam line for nuclear data measurements, are also being developed in phases. The physical design of the beam line is carried out with the help of a complicated collimation system and a sophisticated neutron dump, taking the overview of the neutron beam characteristics into account. This includes energy spectrum, flux and time structure, the optimizations of neutron beam spots and in-hall background. The wide neutron energy range of 1eV-100MeV is excellent for supporting different applications, especially nuclear data measurements. At Endstation#2, which is about 80m away from the target, the main properties of the beam line include neutron flux of 10 6 n/cm 2 /s, time resolution of a few per mille over nearly the entire energy range, and in-hall background of about 0.01/cm 2 /s for both neutron and gamma. With its first commission in late 2017, Back-n will not only be the first high-performance white neutron source in China, but also one of the best white neutron sources in the world. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Foreign Exchange Reserves and the Reserve Bank’s Balance Sheet

    OpenAIRE

    Christian Vallence

    2012-01-01

    The Reserve Bank of Australia holds and manages the nation’s foreign exchange reserve assets in order to meet its policy objectives. While Australia’s foreign exchange reserves are relatively modest by international standards, they nonetheless constitute a sizeable portion of the Bank’s balance sheet, and variations in the Australian dollar value of these reserves are usually the most volatile component of the Bank’s profit and loss statement. This article discusses some of the key decisions ...

  10. Statistical Model Checking for Product Lines

    DEFF Research Database (Denmark)

    ter Beek, Maurice H.; Legay, Axel; Lluch Lafuente, Alberto

    2016-01-01

    We report on the suitability of statistical model checking for the analysis of quantitative properties of product line models by an extended treatment of earlier work by the authors. The type of analysis that can be performed includes the likelihood of specific product behaviour, the expected...... average cost of products (in terms of the attributes of the products’ features) and the probability of features to be (un)installed at runtime. The product lines must be modelled in QFLan, which extends the probabilistic feature-oriented language PFLan with novel quantitative constraints among features...... behaviour converge in a discrete-time Markov chain semantics, enabling the analysis of quantitative properties. Technically, a Maude implementation of QFLan, integrated with Microsoft’s SMT constraint solver Z3, is combined with the distributed statistical model checker MultiVeStA, developed by one...

  11. Wind offering in energy and reserve markets

    DEFF Research Database (Denmark)

    Soares, Tiago; Pinson, Pierre; Morais, Hugo

    2016-01-01

    The increasing penetration of wind generation in power systems to fulfil the ambitious European targets will make wind power producers to play an even more important role in the future power system. Wind power producers are being incentivized to participate in reserve markets to increase their re......The increasing penetration of wind generation in power systems to fulfil the ambitious European targets will make wind power producers to play an even more important role in the future power system. Wind power producers are being incentivized to participate in reserve markets to increase...... dayahead and balancing market is performed. A set of numerical examples illustrate the behavior of such strategy. An important conclusion is that the optimal split of the available wind power between energy and reserve strongly depends upon prices and penalties on both market trading floors....

  12. Status report: A hydrologic framework for the Oak Ridge Reservation

    International Nuclear Information System (INIS)

    Solomon, D.K.; Toran, L.E.; Dreier, R.B.; Moore, G.K.; McMaster, W.M.

    1992-05-01

    This first status report on the Hydrologic Studies Task of the Oak Ridge Reservation Hydrology and Geology Study (ORRHAGS) revises earlier concepts of subsurface hydrology and hydrogeochemistry of the ORR. A new classification of hydrogeologic units is given, as well as new interpretations of the gydrogeologic properties and processes that influence contaminant migration. The conceptual hydrologic framework introduced in this report is based primarily on reinterpretations of data acquired during earlier hydrologic investigations of waste areas at and near the three US Department of Energy Oak Ridge (DOE-OR) plant facilities. In addition to describing and interpreting the properties and processes of the groundwater systems as they are presently understood, this report describes surface water-subsurface water relations, influences on contaminant migration,and implications to environmental restoration, environmental monitoring, and waste management

  13. Multiple Lines of Evidence

    Energy Technology Data Exchange (ETDEWEB)

    Amidan, Brett G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Venzin, Alexander M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bramer, Lisa M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-06-03

    This paper discusses the process of identifying factors that influence the contamination level of a given decision area and then determining the likelihood that the area remains unacceptable. This process is referred to as lines of evidence. These lines of evidence then serve as inputs for the stratified compliance sampling (SCS) method, which requires a decision area to be divided into strata based upon contamination expectations. This is done in order to focus sampling efforts more within stratum where contamination is more likely and to use the domain knowledge about these likelihoods of the stratum remaining unacceptable to buy down the number of samples necessary, if possible. Two different building scenarios were considered as an example (see Table 3.1). SME expertise was elicited concerning four lines of evidence factors (see Table 3.2): 1) amount of contamination that was seen before decontamination, 2) post-decontamination air sampling information, 3) the applied decontaminant information, and 4) the surface material. Statistical experimental design and logistic regression modelling were used to help determine the likelihood that example stratum remained unacceptable for a given example scenario. The number of samples necessary for clearance was calculated by applying the SCS method to the example scenario, using the estimated likelihood of each stratum remaining unacceptable as was determined using the lines of evidence approach. The commonly used simple random sampling (SRS) method was also used to calculate the number of samples necessary for clearance for comparison purposes. The lines of evidence with SCS approach resulted in a 19% to 43% reduction in total number of samples necessary for clearance (see Table 3.6). The reduction depended upon the building scenario, as well as the level of percent clean criteria. A sensitivity analysis was also performed showing how changing the estimated likelihoods of stratum remaining unacceptable affect the number

  14. Right hemisphere role in cognitive reserve.

    Science.gov (United States)

    Robertson, Ian H

    2014-06-01

    High levels of education, occupational complexity, and/or premorbid intelligence are associated with lower levels of cognitive impairment than would be expected from a given brain pathology. This has been observed across a range of conditions including Alzheimer's disease (Roe et al., 2010), stroke (Ojala-Oksala et al., 2012), traumatic brain injury (Kesler et al., 2003), and penetrating brain injury (Grafman, 1986). This cluster of factors, which seemingly protect the brain from expressing symptoms of damage, has been termed "cognitive reserve" (Stern, 2012). The current review considers one possible neural network, which may contribute to cognitive reserve. Based on the evidence that the neurotransmitter, noradrenaline mediates cognitive reserve's protective effects (Robertson, 2013) this review identifies the neurocognitive correlates of noradrenergic (NA) activity. These involve a set of inter-related cognitive processes (arousal, sustained attention, response to novelty, and awareness) with a strongly right hemisphere, fronto-parietal localization, along with working memory, which is also strongly modulated by NA. It is proposed that this set of processes is one plausible candidate for partially mediating the protective effects of cognitive reserve. In addition to its biological effects on brain structure and function, NA function may also facilitate networks for arousal, novelty, attention, awareness, and working memory, which collectively provide for a set of additional, cognitive, mechanisms that help the brain adapt to age-related changes and disease. It is hypothesized that to the extent that the lateral surface of the right prefrontal lobe and/or the right inferior parietal lobe maintain structural (white and gray matter) and functional integrity and connectivity, cognitive reserve should benefit and behavioral expression of pathologic damage should thus be mitigated. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. Network-Based Substrate of Cognitive Reserve in Alzheimer's Disease.

    Science.gov (United States)

    Serra, Laura; Mancini, Matteo; Cercignani, Mara; Di Domenico, Carlotta; Spanò, Barbara; Giulietti, Giovanni; Koch, Giacomo; Marra, Camillo; Bozzali, Marco

    2017-01-01

    Cognitive reserve (CR) is known to modulate the clinical features of Alzheimer's disease (AD). This concept may be critical for the development of non-pharmacological interventions able to slow down patients' cognitive decline in the absence of disease-modifying treatments. We aimed at identifying the neurobiological substrates of CR (i.e., neural reserve) over the transition between normal aging and AD, by assessing the underlying brain networks and their topological properties. A cohort of 154 participants (n = 68 with AD, n = 61 with amnestic mild cognitive impairment (aMCI), and 25 healthy subjects) underwent resting-state functional MRI and neuropsychological testing. Within each group, participants were classified as having high or low CR, and functional connectivity measures were compared, within group, between high and low CR individuals. Network-based statistics and topological network properties derived from graph theory were explored. Connectivity differences between high and low CR were evident only for aMCI patients, with participants with high CR showing a significant increase of connectivity in a network involving mainly fronto-parietal nodes. Conversely, they showed significantly decreased connectivity in a network involving fronto-temporo-cerebellar nodes. Consistently, changes to topological measures were observed in either direction, and were associated with measures of global cognitive function. These findings support the hypothesis that CR impacts on neurodegenerative process in the early phase of AD only. In addition, they fit with the existence of a "neural reserve", characterized by specific neural networks and their efficiency. It remains to be demonstrated whether interventions later in life can modulate this "neural reserve".

  16. Risk spreading, connectivity, and optimal reserve spacing.

    Science.gov (United States)

    Blowes, Shane A; Connolly, Sean R

    2012-01-01

    Two important processes determining the dynamics of spatially structured populations are dispersal and the spatial covariance of demographic fluctuations. Spatially explicit approaches to conservation, such as reserve networks, must consider the tension between these two processes and reach a balance between distances near enough to maintain connectivity, but far enough to benefit from risk spreading. Here, we model this trade-off. We show how two measures of metapopulation persistence depend on the shape of the dispersal kernel and the shape of the distance decay in demographic covariance, and we consider the implications of this trade-off for reserve spacing. The relative rates of distance decay in dispersal and demographic covariance determine whether the long-run metapopulation growth rate, and quasi-extinction risk, peak for adjacent patches or intermediately spaced patches; two local maxima in metapopulation persistence are also possible. When dispersal itself fluctuates over time, the trade-off changes. Temporal variation in mean distance that propagules are dispersed (i.e., propagule advection) decreases metapopulation persistence and decreases the likelihood that persistence will peak for adjacent patches. Conversely, variation in diffusion (the extent of random spread around mean dispersal) increases metapopulation persistence overall and causes it to peak at shorter inter-patch distances. Thus, failure to consider temporal variation in dispersal processes increases the risk that reserve spacings will fail to meet the objective of ensuring metapopulation persistence. This study identifies two phenomena that receive relatively little attention in empirical work on reserve spacing, but that can qualitatively change the effectiveness of reserve spacing strategies: (1) the functional form of the distance decay in covariance among patch-specific demographic rates and (2) temporal variation in the shape of the dispersal kernel. The sensitivity of metapopulation

  17. Estimating Quartz Reserves Using Compositional Kriging

    Directory of Open Access Journals (Sweden)

    J. Taboada

    2013-01-01

    Full Text Available The aim of this study was to determine spatial distribution and volume of four commercial quartz grades, namely, silicon metal, ferrosilicon, aggregate, and kaolin (depending on content in impurities in a quartz seam. The chemical and mineralogical composition of the reserves in the seam were determined from samples collected from outcrops, blasting operations, and exploratory drilling, and compositional kriging was used to calculate the volume and distribution of the reserves. A more accurate knowledge of the deposit ensures better mine planning, leading to higher profitability and an improved relationship with the environment.

  18. Observations of the temporal variability in aerosol properties and their relationships to meteorology in the summer monsoonal South China Sea/East Sea: the role of monsoonal flows, the Madden-Julian Oscillation, tropical cyclones, squall lines and cold pools

    Science.gov (United States)

    Reid, J. S.; Lagrosas, N. D.; Jonsson, H. H.; Reid, E. A.; Sessions, W. R.; Simpas, J. B.; Uy, S. N.; Boyd, T. J.; Atwood, S. A.; Blake, D. R.; Campbell, J. R.; Cliff, S. S.; Holben, B. N.; Holz, R. E.; Hyer, E. J.; Lynch, P.; Meinardi, S.; Posselt, D. J.; Richardson, K. A.; Salinas, S. V.; Smirnov, A.; Wang, Q.; Yu, L. E.; Zhang, J.

    2014-08-01

    troposphere transport was possible on the western sides of Sumatra and Borneo. At the hourly time scale, particle concentrations were observed to be modulated by integer factors through convection and associated cold pools. Geostationary satellite observations suggest that convection often takes the form of squall lines, which are bowed up to 500 km across the monsoonal flow and 50 km wide. These squall lines, initiated by cold pools from large thunderstorms and likely sustained by a veering vertical wind shear, propagated over 1500 km across the entirety of the SCS/ES-effectively cutting large swaths of MBL aerosol particles out of the region. Our conclusion is that while large-scale flow patterns are very important in modulating convection and hence allowing long range transport of smoke and pollution, more short-lived phenomena can modulate cloud condensation nuclei (CCN) concentrations in the region, resulting in pockets of clean and polluted MBL air.

  19. Line Fitting Using Hough-Like Procedure

    Directory of Open Access Journals (Sweden)

    P. Farkas

    2001-04-01

    Full Text Available The Hough Transform is an image processing algorithm which is usedto extract geometric primitives from digital images. It has a number ofdesirable properties, typically robustness to noise and data occlusion.In this paper a new approach to line fitting problem based on HoughTransform is presented. A critical comparison is made with the moretraditional least squares method and potential benefits arising fromthe application of the proposed HT method is illustrated by examples.

  20. Estimation of Uncertainles in Gas-Condensate Systems Reserves by Monte Carlo Simulation

    Directory of Open Access Journals (Sweden)

    Nagy Stanislaw

    2004-09-01

    Full Text Available In the paper, an impact of improper condensate sampling on calculation of gas and condensate reserves of gas-condensate system is presented. The paper discusses probabilistic methods in reserves estimation (proven, possible, probable. The Peng-Robinson equation of state (EOS has been used to calculations of phase properties. Sensitivity of CGR during recombination of stream process on liquid and gas reserves has been shown. The large error in estimation of condensate reserve has been obtained. The impact of CGR error on the vapor phase reserve is small.

  1. Draw the Line!

    DEFF Research Database (Denmark)

    Draw the Line! International Conference, Copenhagen 2008 Papers, proceedings and recommendations is the second publication of the international three year long project "Understanding Puzzles in the Gendered European Map" (UPGEM), which is financed by the European Commission. In this publication we...... present proceedings from the UPGEM conference "Draw the Line!" in Copenhagen May 2008. The proceedings include contributions by UPGEM researchers, conference speeches by other researchers, politicians and gender equality officers in which they relate their work and research with the research done in UPGEM....... The UPGEM research has previously been published in national reports from each of the partner countries (Denmark, Estonia, Finland, Italy and Poland). In these individual national reports of universities as workplaces for male and female researchers we discuss scientific cultures in physics embedded...

  2. Adaptive method of lines

    CERN Document Server

    Saucez, Ph

    2001-01-01

    The general Method of Lines (MOL) procedure provides a flexible format for the solution of all the major classes of partial differential equations (PDEs) and is particularly well suited to evolutionary, nonlinear wave PDEs. Despite its utility, however, there are relatively few texts that explore it at a more advanced level and reflect the method''s current state of development.Written by distinguished researchers in the field, Adaptive Method of Lines reflects the diversity of techniques and applications related to the MOL. Most of its chapters focus on a particular application but also provide a discussion of underlying philosophy and technique. Particular attention is paid to the concept of both temporal and spatial adaptivity in solving time-dependent PDEs. Many important ideas and methods are introduced, including moving grids and grid refinement, static and dynamic gridding, the equidistribution principle and the concept of a monitor function, the minimization of a functional, and the moving finite elem...

  3. CRUCIBLE LINING METHOD

    Science.gov (United States)

    Bone, W.H.; Schmidt, W.W.

    1958-11-01

    A method is presented for forming refractory liners in cylindrical reaction vessels used for the reductlon of uranium tetrafluoride to metallic uranium. A preliminary form, having positioning lugs attached thereto, is inserted into the reaction vessel and the refractory powder, usually CaO, is put in the annular space between the form and the inner wall of the reaction vessel. A jolting table is used to compact this charge of liner material ln place, and after thls has been done, the preliminary form is removed and the flnal form or plug is lnserted without disturbing the partially completed lining. The remainder of the lining charge is then introduced and compacted by jolting, after which the form is removed.

  4. Remote mechanical C line

    International Nuclear Information System (INIS)

    Nuttall, K.R.; Gardner, P.R.

    1991-01-01

    Westinghouse Hanford Company is developing a desk-top simulation based training program on the operation of the Remote Mechanical C (RMC) Line process in the Plutonium Finishing Plant on the Hanford site, Richland, Washington. Simulations display aod contioually update current values of system parameters on computer graphics of RMC line equipment. Students are able to operate a variety of controllers to maintain proper system status. Programmed faults, selectable by the course instructor, can be used to test student responses to off-normal events. Prior to operation of the simulation, students are given computer-based tutorials on the function, processes, operation, and error conditions associated with individual components. By including the capability of operating each individual component - valves, heaters, agitators, etc. - the computer-based training (CBT) lessons become an interactive training manual. From one perspective RMC represents one step in the diffusion of the well-known and well-documented simulator training activities for nuclear reactor operators to other training programs, equally critical, perhaps, but less well scrutinized in the past. Because of the slowly responding nature of the actual process, RMC can retain many of the capabilities of practice and testing in a simulated work environment while avoiding the cost of a full scale simulator and the exposure and waste developed by practice runs of the RMC line. From another perspective RMC suggests training advances even beyond the most faithful simulators. For example, by integrating CBT lessons with the simulation, RMC permits students to focus in on specific processes occurring inside chosen components. In effect, the interactive training manual is available on-line with the simulation itself. Cost are also discussed

  5. AKT and MET signalling mediates antiapoptotic radioresistance in head neck cancer cell lines.

    Science.gov (United States)

    Ettl, Tobias; Viale-Bouroncle, Sandra; Hautmann, Matthias G; Gosau, Martin; Kölbl, Oliver; Reichert, Torsten E; Morsczeck, Christian

    2015-02-01

    Induction of apoptosis is a major mechanism of radiosensitivity in different types of cancer. In contrast, EGFR/PI3K/AKT signalling and recently the presence of so-called cancer stem cells are discussed as reasons for radioresistance. The study investigates mechanisms of apoptosis, key oncogenes of the PI3K/AKT pathway and the presence of cancer cells with stem cell properties during irradiation in two cell lines (PCI-9A, and PCI-15) of head and neck squamous cell carcinoma. WST-1-tests, qRT-PCR, western blots and FACS analysis were performed for analysis. The two cell lines presented different degrees of cell death upon irradiation. The radiosensitive cell line PCI-9A showed increased apoptosis after irradiation measured by expressed cleaved caspases 3 and 7 while the radioresistant cell line PCI-15 upregulated antiapoptotic Survivin and BCL2A1 mRNA. Besides, increased PI3K/AKT- and ERK1/2-signalling was associated with radioresistance accompanied by loss of PTEN function through phosphorylation on S380. Blockade of pAKT increased radiation-induced cell death, and moreover, led to an upregulation of pMET in the radioresistant cell line. The percentage of ALDH-positive tumour cells was markedly decreased after irradiation in the radiosensitive cell line. Functional apoptosis is mandatory for sensitivity to irradiation in head neck cancer cells. Upregulation of the AKT-pathway seems to be one reason for poor radioresponse. Activated MET may also predict radioresistance, possibly through ERK1/2 signalling. Moreover MET may indicate the presence of cancer stem cells facilitating radioresistance as shown by increased ALDH expression. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Hydrogen Stark Broadened Brackett lines

    Directory of Open Access Journals (Sweden)

    C. Stehlé

    2010-01-01

    Full Text Available Stark-broadened lines of the hydrogen Brackett series are computed for the conditions of stellar atmospheres and circumstellar envelopes. The computation is performed within the Model Microfield Method, which includes the ion dynamic effects and makes the bridge between the impact limit at low density and the static limit at high density and in the line wings. The computation gives the area normalized line shape, from the line core up to the static line wings.

  7. A PAT approach for the on-line monitoring of pharmaceutical co-crystals formation with near infrared spectroscopy.

    Science.gov (United States)

    Sarraguça, Mafalda C; Ribeiro, Paulo R S; Santos, Adenilson O; Silva, Marta C D; Lopes, João A

    2014-08-25

    Cocrystals represent a class of crystalline solids consisting of two or more molecular species usually held together by non-covalent bonds. Pharmaceutical cocrystals can alter the physicochemical properties of the active pharmaceutical ingredient to improve solubility, dissolution rate, particle properties and stability. This work presents a process analytical technology (PAT) approach to monitor on-line the cocrystallization of furosemide and adenine by solvent evaporation using near infrared spectroscopy (NIRS). Furosemide and adenine were added to a small volume of methanol in a beaker and stirred on an orbital stirring table during 8h at room temperature. The on-line monitoring was performed with a FT-NIR spectrometer fitted with a reflectance fiber optic probe. Monitoring was performed with the probe tip placed 1cm above the cocrystallization medium to avoid interference with the cocrystallization process. Cocrystals were vacuum dried to remove residual solvent and characterized off-line by NIRS, MIRS, DSC and XRPD. Results demonstrate that it was possible to follow the main cocrystallization events on-line. Copyright © 2014 Elsevier B.V. All rights reserved.

  8. Line managers as marketers.

    Science.gov (United States)

    Rynne, T J

    1986-09-01

    Many hospital administrators and boards of directors, having overcome their initial opposition to advertising and hired a marketing professional, are wondering why their marketing programs have not accomplished all that they had hoped. The answer lies in their perception of who is responsible for marketing. Marketing is not a specialty separate from the disciplines of management--it is a basic management skill. Its goal is to satisfy the customer by providing products and services that meet the customer's needs, wants, and preferences. Line managers must understand the hospital's customers and make the critical day-to-day differences in satisfying them. They are the hospital's front-line marketers, and the marketing department's role is to support them in this function. The marketing department should develop the line managers' marketing skills by furnishing them with the appropriate tools: formats, models, examples, and instructions. In addition, the marketing staff should provide such specialized services as marketing research, ad agency management, and development of communications.

  9. Demand as Frequency-controlled Reserve

    DEFF Research Database (Denmark)

    Bang, Christian; Rasmussen, Christian Brandt; Østergaard, Jacob

    electric loads to provide frequency controlled primary reserves. The devices collected data from domestic households and industrial loads covering i.e. circulation pumps, electrical domestic heating, bottle coolers, a wastewater treatment plant etc., that have been analysed and used for the papers...

  10. 34 CFR 300.811 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false [Reserved] 300.811 Section 300.811 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH...

  11. 34 CFR 300.805 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false [Reserved] 300.805 Section 300.805 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH...

  12. Use of reserve substances by irradiated tubers

    International Nuclear Information System (INIS)

    Perez Tabares, Francisco; Perez Talavera, Susana

    1999-01-01

    The response of tubers of potato (Solanum tuberosun L.) and sweet potato (Ipomoea batatas L.) to gamma radiation from 60 Co were investigated. The use of reserve substances by the tubers increased when the irradiation dose raise up to the level of GR10-20 and then decreased down to the values lower than the control non-irradiated tubers

  13. Diminished ovarian reserve in patients with psoriasis

    Directory of Open Access Journals (Sweden)

    Burcu Tuğrul Ayanoğlu

    2018-04-01

    Full Text Available Objective: Psoriasis is a multi-systemic chronic inflammatory skin disease. Previous data suggests that women with some chronic inflammatory diseases have diminished ovarian reserve. This study explores ovarian reserve in patients with psoriasis. Materials and methods: We prospectively analyzed 14 female patients with psoriasis and 35 healthy age and body mass index matched controls. An interview explored demographic characteristics, obstetrical history and menstrual characteristics. Psoriatic area severity index (PASI in patients was assessed. Estrogen, follicle-stimulating hormone (FSH, luteinizing hormone (LH, thyroid stimulating hormone and with gynecologic ultrasonography, ovarian volume and antral follicular count (AFC were measured in both study and control groups. These values were analyzed with changes of the PASI in the patient group. Results: Patients with psoriasis had significantly higher levels of FSH and FSH/LH ratio than healthy controls (p = 0.039, p = 0.005 respectively. AFC of psoriasis patients were significantly lower than healthy controls (p = 0.002.There were no significant difference among other hormone levels and ovarian volumes (p > 0.05. The hormone levels, ovarian volume and AFC were not correlated with PASI of the patients. Conclusion: The results of the study suggest that patients with psoriasis may have diminished ovarian reserve. Keywords: Psoriasis, Ovarian reserve, Psoriatic area severity index, Antral follicular count, Follicle-stimulating hormone

  14. 49 CFR 236.533 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false [Reserved] 236.533 Section 236.533 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RULES, STANDARDS, AND INSTRUCTIONS GOVERNING THE INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR...

  15. 49 CFR 236.704 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false [Reserved] 236.704 Section 236.704 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RULES, STANDARDS, AND INSTRUCTIONS GOVERNING THE INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR...

  16. 49 CFR 236.561 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false [Reserved] 236.561 Section 236.561 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RULES, STANDARDS, AND INSTRUCTIONS GOVERNING THE INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR...

  17. 49 CFR 236.530 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false [Reserved] 236.530 Section 236.530 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RULES, STANDARDS, AND INSTRUCTIONS GOVERNING THE INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR...

  18. Oak Ridge Reservation Waste Management Plan

    Energy Technology Data Exchange (ETDEWEB)

    Turner, J.W. [ed.

    1995-02-01

    This report presents the waste management plan for the Oak Ridge Reservation facilities. The primary purpose is to convey what facilities are being used to manage wastes, what forces are acting to change current waste management systems, and what plans are in store for the coming fiscal year.

  19. Optimization of Marine Forces Reserve Equipment Redistribution

    Science.gov (United States)

    2016-06-01

    industry as an example. Bertrand and Bookbinder begin with a basic supply chain logistics model of a large warehouse supplying a number of retail...solutions, and perform fast sensitivity analysis on the competing objectives. 14. SUBJECT TERMS Optimization, Marine Forces Reserve, redistribution...reallocation, equipment supply , logistics 15. NUMBER OF PAGES 61 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT Unclassified 18. SECURITY

  20. Wind offering in energy and reserve markets

    Science.gov (United States)

    Soares, T.; Pinson, P.; Morais, H.

    2016-09-01

    The increasing penetration of wind generation in power systems to fulfil the ambitious European targets will make wind power producers to play an even more important role in the future power system. Wind power producers are being incentivized to participate in reserve markets to increase their revenue, since currently wind turbine/farm technologies allow them to provide ancillary services. Thus, wind power producers are to develop offering strategies for participation in both energy and reserve markets, accounting for market rules, while ensuring optimal revenue. We consider a proportional offering strategy to optimally decide upon participation in both markets by maximizing expected revenue from day-ahead decisions while accounting for estimated regulation costs for failing to provide the services. An evaluation of considering the same proportional splitting of energy and reserve in both day- ahead and balancing market is performed. A set of numerical examples illustrate the behavior of such strategy. An important conclusion is that the optimal split of the available wind power between energy and reserve strongly depends upon prices and penalties on both market trading floors.

  1. Clipboard: Unraveling the mystery of cognitive reserve

    Indian Academy of Sciences (India)

    Aging; Alzheimer's; bilingualism; cognitive reserve; dementia; Down's; education; enrichment; environment; learning; long term potentiation; LTP; memory; neuroepigenetics; plasticity ... Institute of Cognitive Neuroscience, University College London Alexandra House, 17-19 Queen Square, London WC1N 3AR, England ...

  2. Oak Ridge Reservation Waste Management Plan

    International Nuclear Information System (INIS)

    Turner, J.W.

    1995-02-01

    This report presents the waste management plan for the Oak Ridge Reservation facilities. The primary purpose is to convey what facilities are being used to manage wastes, what forces are acting to change current waste management systems, and what plans are in store for the coming fiscal year

  3. 40 CFR 80.605 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 80.605 Section 80.605 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Motor Vehicle Diesel Fuel; Nonroad, Locomotive, and Marine Diesel Fuel; and ECA...

  4. 40 CFR 80.609 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 80.609 Section 80.609 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Motor Vehicle Diesel Fuel; Nonroad, Locomotive, and Marine Diesel Fuel; and ECA...

  5. 40 CFR 80.534 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 80.534 Section 80.534 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Motor Vehicle Diesel Fuel; Nonroad, Locomotive, and Marine Diesel Fuel; and ECA...

  6. Study on Online Hotel Reservation Systems

    OpenAIRE

    Alleweldt, Frank; Tonner, Klaus; McDonald, Marc

    2009-01-01

    This study, conducted by Civic Consulting, looks at both pre-contractual and contractual matters concerning online hotel reservation systems, examines relevant Community rules, identifies gaps and, where needed, discusses possible policy options. Key conclusions The study shows that the impact of Community law on online hotel

  7. 10 CFR 51.99 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false [Reserved] 51.99 Section 51.99 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) Final Environmental...

  8. 27 CFR 27.205 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false [Reserved] 27.205 Section 27.205 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS IMPORTATION OF DISTILLED SPIRITS, WINES, AND BEER Requirements for Liquor Bottles...

  9. Your Money and the Federal Reserve System.

    Science.gov (United States)

    Federal Reserve Bank of Minneapolis, Minn.

    The booklet explores various roles which money has played throughout history and examines the relationship between money and the Federal Reserve System. The major objective is to increase understanding of the performance of various functions such as making money work as a medium of exchange and as a measure of value and of storing value for future…

  10. Mental Reservation and Military Testimony before Congress

    National Research Council Canada - National Science Library

    Roberts, Gordon R

    2008-01-01

    .... The cause for this apparent mental reservation on the part of military leaders can be found in their organizational bias and environmental influences, but the solution can be found in history. It is vital for the military to understand that a currency of truth is the most important contribution it can make to the civilian-military relationship.

  11. 7 CFR 3560.306 - Reserve account.

    Science.gov (United States)

    2010-01-01

    ...) As projects age, the required reserve account level may be adjusted to meet anticipated “life-cycle...) Purpose. To meet the major capital expense needs of a housing project, borrowers must establish and... be deemed to contain surplus funds when the balance at the end of the housing project's fiscal year...

  12. 18 CFR 4.91 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 4.91 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT LICENSES, PERMITS, EXEMPTIONS, AND DETERMINATION OF PROJECT COSTS Exemption of Small Conduit Hydroelectric Facilities § 4.91 [Reserved] ...

  13. Unanswered Quibbles with Fractional Reserve Free Banking

    Directory of Open Access Journals (Sweden)

    Philipp Bagus

    2011-07-01

    Full Text Available In this article we reply to George Selgin’s counterarguments to our article “Fractional Reserve Free Banking: Some Quibbles”. Selgin regards holding cash as saving while we focus on the real savings necessary to maintain investment projects. Real savings are unconsumed real income. Variations in real savings are not necessarily equal to variations in cash holdings. We show that a coordinated credit expansion in a fractional reserve free banking (FRFB system is possible and that precautionary reserves consequently do not pose a necessary limit. We discuss various instances in which a FRFB system may expand credit without a prior increase in real savings. These facets all demonstrate why a fractional reserve banking system – even a free banking one – is inherently unstable, and incentivized to impose a stabilizing central bank. We find that at the root of our disagreements with Selgin lies a different approach to monetary theory. Selgin subscribes to the aggregative equation of exchange, which impedes him from seeing the microeconomic problems that the stabilization of “MV” by a FRFB system causes.

  14. 78 FR 66715 - Federal Reserve Bank Services

    Science.gov (United States)

    2013-11-06

    ... imputed costs and earn net income of $24.6 million, compared with the target of $4.2 million. Although the... initiatives, and to increase product revenue. 4.2014 Pricing--The following summarizes the Reserve Banks... Banks will discontinue the Choice Receiver program, which provides pricing incentives to those customers...

  15. 40 CFR 427.84 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false [Reserved] 427.84 Section 427.84 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Coating or Finishing of Asbestos Textiles Subcategory § 427.84...

  16. 40 CFR 86.220-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.220-94 Section 86.220-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

  17. 40 CFR 86.217-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.217-94 Section 86.217-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

  18. 40 CFR 86.212-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.212-94 Section 86.212-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

  19. 40 CFR 86.241-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.241-94 Section 86.241-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

  20. 40 CFR 86.207-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.207-94 Section 86.207-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

  1. 40 CFR 86.243-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.243-94 Section 86.243-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

  2. 40 CFR 428.64 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false [Reserved] 428.64 Section 428.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS RUBBER MANUFACTURING POINT SOURCE CATEGORY Medium-Sized General Molded, Extruded, and Fabricated Rubber...

  3. 40 CFR 86.210-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.210-94 Section 86.210-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

  4. 40 CFR 86.245-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.245-94 Section 86.245-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

  5. 40 CFR 86.225-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.225-94 Section 86.225-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

  6. 5 CFR 330.710 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false [Reserved] 330.710 Section 330.710 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND PLACEMENT (GENERAL) Interagency Career Transition Assistance Plan for Displaced Employees § 330.710...

  7. 5 CFR 330.702 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false [Reserved] 330.702 Section 330.702 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND PLACEMENT (GENERAL) Interagency Career Transition Assistance Plan for Displaced Employees § 330.702...

  8. Using Program Package NSPCG to Analyze the Trunk Reservation Service Protection Method

    DEFF Research Database (Denmark)

    Barker, Vincent A.; Nielsen, Bo Friis

    1994-01-01

    Unlike certain service protection methods for mixed traffic streams, such as the class-limitation method, the trunk reservation scheme cannot be based on a product form property of a stationary probability distribution vector. Rather, the analysis of the trunk reservation scheme requires solving...

  9. 46 CFR 387.6 - Terms, reservations, restrictions, and conditions of conveyance.

    Science.gov (United States)

    2010-10-01

    ... by a quitclaim deed or deeds on an “as is, where is” basis without any warranty, expressed or implied... 46 Shipping 8 2010-10-01 2010-10-01 false Terms, reservations, restrictions, and conditions of... § 387.6 Terms, reservations, restrictions, and conditions of conveyance. (a) Conveyances of property...

  10. Planning outstanding reserves in general insurance

    Science.gov (United States)

    Raeva, E.; Pavlov, V.

    2017-10-01

    Each insurance company have to ensure its solvency through presentation of accounts for its own reserves in the start of the year. Usually the task of the actuary is to estimate the state of the company on an annual basis and the expectation of the status of the company for a future period. One of the major problem when calculating the liabilities of the incurred claims, is related to the delay of payments. Object of consideration in the present note are the outstanding claim reserves, which are set aside to cover claims, occurred before the date of the annual account, but still not paid, and related with them expenses. There may be different reasons for the delay of claims settlement. For example, continuation the process of the liquidation of the damage waiting for necessary documents or the presence of controversial cases whose permission takes time, etc. Thus the claims, which determine the outstanding reserves could be divided in the following types: claims, which are reported, but not settled (RBNS); claims, which are incurred but not reported (IBNR); claims, whose case is finished, but it is possible to be reopened. When calculating the reserves for IBNR claims, most widely used is the Chain-ladder method and its modification presented by the Bornhuetter - Ferguson method. For modeling the outstanding claims, the available data should be presented in so called run-off triangle, which underlies in the basis of such methods. The present work provides a review of the algorithm for calculating insurance outstanding claim reserves according to the Chain-ladder method. Using available data for claims related to liability of drivers, registered in Bulgaria an example is constructed to illustrate the methodology of the Chain-Ladder method. Back-testing approach is used for validating the results.

  11. Socioeconomic profiles of native American communities: Yomba Shoshone Reservation

    International Nuclear Information System (INIS)

    Hamby, M.; Rusco, E.

    1991-10-01

    This report was written by the State of Nevada Agency for Nuclear Projects/Nuclear Waste Project Office. This office oversees the nuclear waste activities for the proposed Yucca Mountain high-level waste facility for the state of Nevada. The Yomba Shoshone Reservation socio-economic profile was the basis of this paper. It describes the life and current status of the Shoshone Indians. Population, utilities, education and social services of the Shoshone are examples of the topics which are discussed. It is intended as base-line information only. It eventually summarizes and compares data from the public opinion of the Shoshone about the high level waste repository at Yucca Mountain. (MB)

  12. 75 FR 73911 - Grassland Reserve Program

    Science.gov (United States)

    2010-11-29

    ... regulatory action. USDA evaluated the economic analysis and expanded it to include net present value analyses... opinion that a market analysis will not accurately reflect the fair market value of a property. The main... significant regulatory action. Pursuant to Executive Order 12866, USDA conducted an economic analysis of the...

  13. Collaborative assessment of California spiny lobster population and fishery responses to a marine reserve network.

    Science.gov (United States)

    Kay, Matthew C; Lenihan, Hunter S; Guenther, Carla M; Wilson, Jono R; Miller, Christopher J; Shrout, Samuel W

    2012-01-01

    Assessments of the conservation and fisheries effects of marine reserves typically focus on single reserves where sampling occurs over narrow spatiotemporal scales. A strategy for broadening the collection and interpretation of data is collaborative fisheries research (CFR). Here we report results of a CFR program formed in part to test whether reserves at the Santa Barbara Channel Islands, USA, influenced lobster size and trap yield, and whether abundance changes in reserves led to spillover that influenced trap yield and effort distribution near reserve borders. Industry training of scientists allowed us to sample reserves with fishery relevant metrics that we compared with pre-reserve fishing records, a concurrent port sampling program, fishery effort patterns, the local ecological knowledge (LEK) of fishermen, and fishery-independent visual surveys of lobster abundance. After six years of reserve protection, there was a four- to eightfold increase in trap yield, a 5-10% increase in the mean size (carapace length) of legal sized lobsters, and larger size structure of lobsters trapped inside vs. outside of three replicate reserves. Patterns in trap data were corroborated by visual scuba surveys that indicated a four- to sixfold increase in lobster density inside reserves. Population increases within reserves did not lead to increased trap yields or effort concentrations (fishing the line) immediately outside reserve borders. The absence of these catch and effort trends, which are indicative of spillover, may be due to moderate total mortality (Z = 0.59 for legal sized lobsters outside reserves), which was estimated from analysis of growth and length frequency data collected as part of our CFR program. Spillover at the Channel Islands reserves may be occurring but at levels that are insufficient to influence the fishery dynamics that we measured. Future increases in fishing effort (outside reserves) and lobster biomass (inside reserves) are likely and may lead to

  14. Exploring the influence of culture conditions on kefir's anticancer properties.

    Science.gov (United States)

    Hatmal, Ma'mon M; Nuirat, Abeer; Zihlif, Malek A; Taha, Mutasem O

    2018-05-01

    Cancer is a major health problem in many parts of the world. Conventional anticancer treatments are painful, expensive, and unsafe. Therefore, demand is increasing for cancer treatments preferentially in the form of functional foods or nutritional supplements. Kefir, a traditional fermented milk dairy product, has significant antimutagenic and antitumor properties. This research addresses the hypothesis that kefir's anticancer properties are affected by fermentation conditions. Initially, kefir extracts prepared under standard conditions were screened against 7 cancer cell lines using the tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay. Colon cancer and chronic myelogenous leukemia cells were found to be most susceptible to kefir extracts. Subsequently, a factorial design was implemented to assess the effects of 3 fermentation times (24, 48, and 72 h), 3 kefir-to-milk ratios (2, 5, and 10% wt/vol), and 3 fermentation temperatures (4, 25, and 40°C) on kefir's anticancer properties. Remarkably, exploration of the fermentation conditions allowed the anticancer properties of kefir to be enhanced by 5- to 8-fold against susceptible cell lines. Overall, these results demonstrate the possibility of optimizing the anticancer properties of kefir as a functional food in cancer therapy. Copyright © 2018 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  15. Macro vs. Micro Methods in Non-Life Claims Reserving (an Econometric Perspective

    Directory of Open Access Journals (Sweden)

    Arthur Charpentier

    2016-05-01

    Full Text Available Traditionally, actuaries have used run-off triangles to estimate reserve (“macro” models, on aggregated data. However, it is possible to model payments related to individual claims. If those models provide similar estimations, we investigate uncertainty related to reserves with “macro” and “micro” models. We study theoretical properties of econometric models (Gaussian, Poisson and quasi-Poisson on individual data, and clustered data. Finally, applications in claims reserving are considered.

  16. Medial fracture line significance in calcaneus fracture.

    Science.gov (United States)

    Ogut, Tahir; Ayhan, Egemen; Kantarci, Fatih; Unlu, Mehmet C; Salih, Muhammet

    2011-01-01

    In Sanders' classification of calcaneus fractures, the medial fracture line (subtype C) is close to the tarsal canal, which contains an artery for the talus and calcaneus. We hypothesized that because of this brittle vascular localization, patients with C line fracture patterns might describe radiologic subtalar arthritis more often and have more complaints. The purpose of the present study was to compare the results of C line fracture patterns with other types of calcaneus fractures. A total of 25 surgically treated feet were involved. Regarding Sanders' classification, group 1 included fractures involving the C line (11 feet), and group 2 included fractures not involving the C line (14 feet). Patient age at admission, trauma date, and interval until surgery were obtained from the patients' medical records. The Bohler angles were determined from the radiographs. At the last follow-up visit, the radiologist graded subtalar arthritis using computed tomography. For clinical follow-up, the American Orthopaedic Foot and Ankle Society and Maryland scores were assessed. No significant differences were found in mean age, follow-up period, delay to surgery, or postoperative Bohler angle between the 2 groups. The mean preoperative Bohler angle was significantly low for group 1. Although not significantly different, the mean American Orthopaedic Foot and Ankle Society and Maryland scores were lower for group 1 (81.9 and 84.3) than group 2 (87.8 and 92.0), and the median subtalar arthritis grade was greater for group 1 (score 2) than for group 2 (score 1.5). The worse results with C line fracture patterns despite satisfactory reduction might result from sinus tarsi artery damage. Angiographic investigations could clarify this theory in the future. Consequently, surgeons must inform and should hesitate to operate on patients with these highly comminuted C line calcaneus fractures. Copyright © 2011 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All

  17. Biophysical Profiling of Tumor Cell Lines

    Directory of Open Access Journals (Sweden)

    Frederick Coffman

    2011-01-01

    Full Text Available Despite significant differences in genetic profiles, cancer cells share common phenotypic properties, including membrane-associated changes that facilitate invasion and metastasis. The Corning Epic® optical biosensor was used to monitor dynamic mass rearrangements within and proximal to the cell membrane in tumor cell lines derived from cancers of the colon, bone, cervix, lung and breast. Data was collected in real time and required no exogenously added signaling moiety (signal-free technology. Cell lines displayed unique profiles over the time-courses: the time-courses all displayed initial signal increases to maximal values, but the rate of increase to those maxima and the value of those maxima were distinct for each cell line. The rate of decline following the maxima also differed among cell lines. There were correlations between the signal maxima and the observed metastatic behavior of the cells in xenograft experiments; for most cell types the cells that were more highly metastatic in mice had lower time-course maxima values, however the reverse was seen in breast cancer cells. The unique profiles of these cell lines and the correlation of at least one profile characteristic with metastatic behavior demonstrate the potential utility of biophysical tumor cell profiling in the study of cancer biology.

  18. From atomic lines to the diamond

    International Nuclear Information System (INIS)

    Soukiassian, P.; CEA Saclay, 91 - Gif-sur-Yvette; Dujardin, G.

    1999-01-01

    Silicon carbide (SiC) is widely used in industrial applications. Exceptional semi-conductor properties added to an ability to sustain high temperatures (up to 1000 K) and chemical inertia make SiC a material of a great interest in electronics. SiC is used in semi-conductor detectors designed to operate in harsh conditions. The observation of SiC crystal surfaces by means of a tunnel effect microscope has revealed prominent and regular lines of either silicon or carbon atoms. These lines are parallel and can be used as a die ready to receive a metallic deposition, in that manner the space between 2 lines could be turned into a 2 atom broad conductive track. This perspective opens new ways for SiC in electronic applications.The atomic lines made up of carbon define a plane in which atoms have the same type of bound as in a diamond crystal. These lines could be used to favour the growth of mono-crystal diamond films and then produce a SiC-diamond combined material which could be very promising for the next generation of particle detectors. (A.C.)

  19. Contaminant transport model validation: The Oak Ridge Reservation

    International Nuclear Information System (INIS)

    Lee, R.R.; Ketelle, R.H.

    1988-09-01

    In the complex geologic setting on the Oak Ridge Reservation, hydraulic conductivity is anisotropic and flow is strongly influenced by an extensive and largely discontinuous fracture network. Difficulties in describing and modeling the aquifer system prompted a study to obtain aquifer property data to be used in a groundwater flow model validation experiment. Characterization studies included the performance of an extensive suite of aquifer test within a 600-square-meter area to obtain aquifer property values to describe the flow field in detail. Following aquifer test, a groundwater tracer test was performed under ambient conditions to verify the aquifer analysis. Tracer migration data in the near-field were used in model calibration to predict tracer arrival time and concentration in the far-field. Despite the extensive aquifer testing, initial modeling inaccurately predicted tracer migration direction. Initial tracer migration rates were consistent with those predicted by the model; however, changing environmental conditions resulted in an unanticipated decay in tracer movement. Evaluation of the predictive accuracy of groundwater flow and contaminant transport models on the Oak Ridge Reservation depends on defining the resolution required, followed by field testing and model grid definition at compatible scales. The use of tracer tests, both as a characterization method and to verify model results, provides the highest level of resolution of groundwater flow characteristics. 3 refs., 4 figs

  20. Petroleum reserves in West Africa: an overview

    International Nuclear Information System (INIS)

    Copinschi, Ph.; Favennec, J.P.

    1999-01-01

    The Gulf of Guinea region in West Africa is one in which production and reserves have increased the most during the last few years, essentially due to offshore operation. It is also there that the most spectacular discoveries have been made in recent years, particularly with deep-sea drilling. The low production costs and enthusiastic welcome for foreign investors make the region a favoured destination for large international companies, even if uncertainties and political tensions remain to make the situation delicate. In these conditions, the relationship between the host State and the foreign petrol companies are changing. Beyond the purely formal aspects of these new contacts, the whole former system of 'reserved markets' is being threatened by the increasing tendency to open the sector to competition. Eight countries are examined in detail: Nigeria, Angola, Gabon, Congo, Cameroon, Equatorial Guinea, the Ivory Coast and Chad. (authors)

  1. Reserve Component Personnel Issues: Questions and Answers

    Science.gov (United States)

    2017-01-18

    of one day of basic pay for each unit training assembly ( UTA ) they attend. A UTA is generally a four-hour period of instruction, and there are usually...training assembly ( UTA ), one point for each day of annual training (AT), and one point for each day of active duty. Points can also be earned for completing... on the vitality of the reserve components, such as funding, equipment, and personnel policy. This report is designed to provide an overview of key

  2. Developing Senior Leaders for the Reserve Components

    Science.gov (United States)

    2017-01-01

    For more information on the Forces and Resources Policy Center, see http://www.rand.org/nsrd/ndri/centers/frp.html or contact the director (contact information is provided on the web page ). ...some combination of experiences, education, and personal development. Each has an extensive concept of develop- ment—how they define it, what ...policy. First, in what ways can the develop- ment of RC senior leaders be improved? Second, in what ways can reserve component leader development

  3. Bilingualism, dementia, cognitive and neural reserve.

    Science.gov (United States)

    Perani, Daniela; Abutalebi, Jubin

    2015-12-01

    We discuss the role of bilingualism as a source of cognitive reserve and we propose the putative neural mechanisms through which lifelong bilingualism leads to a neural reserve that delays the onset of dementia. Recent findings highlight that the use of more than one language affects the human brain in terms of anatomo-structural changes. It is noteworthy that recent evidence from different places and cultures throughout the world points to a significant delay of dementia onset in bilingual/multilingual individuals. This delay has been reported not only for Alzheimer's dementia and its prodromal mild cognitive impairment phase, but also for other dementias such as vascular and fronto-temporal dementia, and was found to be independent of literacy, education and immigrant status. Lifelong bilingualism represents a powerful cognitive reserve delaying the onset of dementia by approximately 4 years. As to the causal mechanism, because speaking more than one language heavily relies upon executive control and attention, brain systems handling these functions are more developed in bilinguals resulting in increases of gray and white matter densities that may help protect from dementia onset. These neurocognitive benefits are even more prominent when second language proficiency and exposure are kept high throughout life.

  4. World energy demands and coal reserves

    Directory of Open Access Journals (Sweden)

    Ferenc Kovács

    2007-10-01

    Full Text Available On the basis of the expected increase in the world’s population and taking the estimated improvement in both technology and living standards into account, the paper forecasts energy demands. In 2000, actual energy consumption was 380-400 EJ.year-1, the forecast for the year 2050 is 600-1,050 EJ.year-1, while for the year 2100 it is 900-3,600 EJ.year-1. On the basis of the expected shares of the different fuels (coal, mineral oil, natural gas, nuclear energy, renewable energies, it can be assumed that in 2050 coal demand will be between 122-200 EJ.year-1 while the total coal demand for the 45 years ahead is estimated to be 5,500-6,900 EJ.year-1. This rate of demand basically involves an approximately 2 % increase every year.On the basis of data in relevant literature, the world’s coal reserves are: the industrial coal reserve is 800-1,000 · 109 tons, the geological stock is 5-15 1012 tons and the expected stock is 8-35 1012 tons. The world’s industrial coal reserve (which is economically exploitable at the present technological level guarantees supply for 200 years while the detected geological stock guarantees supply for a round 1,000 years.

  5. Gadolinium-153 line sources

    Energy Technology Data Exchange (ETDEWEB)

    Lebedev, V.M. E-mail: kar@orip.niiar.simbirsk.su; Gordeev, J.N.; Karelin, E.A.; Gavrilov, V.D

    2000-11-15

    The technology for Gd-153 line source production has been developed at SSC RIAR. The source active core is made of Al-Gd{sub 2}O{sub 3} composition by means of one of the following ways: either collecting pressed pellets or filling the source body with the composition followed by sintering. The composition is prepared by gadolinium salt thermal destruction on aluminium particles. The method allows setting gadolinium mass fraction (from 0.02 to 6%) with high accuracy and uniformity of distribution in the composition volume of more than 95%.

  6. α-line systematics

    International Nuclear Information System (INIS)

    Caurier, E.; Zuker, A.P.

    1991-01-01

    A study of the α-line, defined as a set of differences (D α ) characterized binding energies of (N,Z) nuclei, is presented. The 2p2n-separation energies for even-even nuclei, odd-odd nuclei, even(Z)-odd(N) nuclei, odd(Z)-even(N) nuclei are presented. Trends and details in even-even nuclei, magic numbers of even-even and odd-odd nuclei are discussed. (G.P.) 1 ref.; 8 figs

  7. America's Assembly Line

    DEFF Research Database (Denmark)

    Nye, David Edwin

    A social history of the assembly line, invented in 1913. Both praised as a boon to consumers and as a curse for workers, it has been satirized, imitated, and celebrated for 100 years. It has inspired fiction, comedy, cafeteria layouts, and suburban housing. It transformed industrial labor...... and provoked strikes and union drives in the 1930s, but became a symbol of victory in the Second World War and Cold War. Reinvented by Japan as "lean production" and then increasingly automated after 1990, it remains a cornerstone of production but no longer employs many workers, even as it evolves toward...

  8. Worldlines as Wilson Lines

    Energy Technology Data Exchange (ETDEWEB)

    Green, Daniel; /SLAC /Stanford U., Dept. Phys.

    2008-04-29

    Gravitational theories do not admit gauge invariant local operators. We study the limits under which there exists a quasi-local description for a class of non-local gravitational observables where a sum over worldlines plays the role of the Wilson line for gauge theory observables. We study non-local corrections to the local description and circumstances where these corrections become large. We find that these operators are quasi-local in at space and AdS, but fail to be quasi-local in de Sitter space.

  9. Coaxial transmission line - Equalization

    International Nuclear Information System (INIS)

    Bonnerue, J.L.; Fremont, Jacques; Haubtmann, Jack; Pillon, Gerard.

    1981-09-01

    The transmission of electrical signal through a coaxial line is not perfect and signal distortions are increased as much as the frequency spectrum is extended. We have designed and achieved passive filters (named equalizers) with transfer functions which are inverse of coaxial transfer functions. Doing so our attempt is to avoid definitive loss of information in the recorded data. The main feature of our equalization method lies in the fact it could be either an electrical or a numerical correction or both of them. Some examples in the use of this technique are also proposed [fr

  10. Disaggregating reserve-to-production ratios: An algorithm for United States oil and gas reserve development

    Science.gov (United States)

    Williams, Charles William

    Reserve-to-production ratios for oil and gas development are utilized by oil and gas producing states to monitor oil and gas reserve and production dynamics. These ratios are used to determine production levels for the manipulation of oil and gas prices while maintaining adequate reserves for future development. These aggregate reserve-to-production ratios do not provide information concerning development cost and the best time necessary to develop newly discovered reserves. Oil and gas reserves are a semi-finished inventory because development of the reserves must take place in order to implement production. These reserves are considered semi-finished in that they are not counted unless it is economically profitable to produce them. The development of these reserves is encouraged by profit maximization economic variables which must consider the legal, political, and geological aspects of a project. This development is comprised of a myriad of incremental operational decisions, each of which influences profit maximization. The primary purpose of this study was to provide a model for characterizing a single product multi-period inventory/production optimization problem from an unconstrained quantity of raw material which was produced and stored as inventory reserve. This optimization was determined by evaluating dynamic changes in new additions to reserves and the subsequent depletion of these reserves with the maximization of production. A secondary purpose was to determine an equation for exponential depletion of proved reserves which presented a more comprehensive representation of reserve-to-production ratio values than an inadequate and frequently used aggregate historical method. The final purpose of this study was to determine the most accurate delay time for a proved reserve to achieve maximum production. This calculated time provided a measure of the discounted cost and calculation of net present value for developing new reserves. This study concluded that

  11. Changing the VP Reserve Readiness System to Match the Crew-Coordination Requirements of Reserve Aircrews

    National Research Council Canada - National Science Library

    Woods, William

    1997-01-01

    .... The current VP readiness system promotes long-term, fixed crews with TACNUC rules. Adhering to these crew composition rules can cause considerable scheduling difficulties for reserve squadrons...

  12. Assessment of renewable energy reserves in Taiwan

    International Nuclear Information System (INIS)

    Chen, Falin; Lu, Shyi-Min; Tseng, Kuo-Tung; Wang, Eric; Lee, Si-Chen

    2010-01-01

    Since Taiwan imports more than 99% of energy supply from foreign countries, energy security has always been the first priority for government to formulate energy policy. The development of renewable energy not only contributes to the independence of energy supply, but also achieves benefits of economic development and environmental protection. Based upon information available to public, the present paper reassesses reserves of various renewable energies in Taiwan. The assessment includes seven kinds of renewable energies, namely, solar energy, wind power, biomass energy, wave energy, tidal energy, geothermal energy and hydropower, which are all commercialized and matured in terms of current technologies. Other renewable energies, which have not proven as matured as the aforementioned ones, are only assessed preliminarily in this paper, such as second generation of biomass, deep geothermal energy, the Kuroshio power generation and ocean thermal energy conversion. According to the estimation of this paper, the reserve of wind energy, up to 29.9 kWh/d/p (i.e., kWh per day per person), is the largest one among seven kinds of renewable energies in Taiwan, followed by 24.27 kWh/d/p of solar energy, 4.55 kWh/d/p of biomass, 4.58 kWh/d/p of ocean energy, 0.67 kWh/d/p of geothermal energy and 16.79 kWh/d/p of hydropower. If regarding biomass as a primary energy, and assuming 40% being the average efficiency to convert primary energy into electricity, the total power of the seven kinds of renewable energy reserves is about 78.03 kWh/d/p, which is equal to 2.75 times of 28.35 kWh/d/p of national power generation in 2008. If the reserves of 54.93 kWh/d/p estimated from other four kinds of renewable energies that have not technically matured yet are also taken into account, it will result that the reserves of renewable energy in Taiwan can be quite abundant. Although the results of the assessment point out that Taiwan has abundant renewable energy resources, the four inherent

  13. Properties and nature of Be stars 30. Reliable physical properties of a semi-detached B9.5e+G8III binary BR CMi = HD 61273 compared to those of other well studied semi-detached emission-line binaries

    Czech Academy of Sciences Publication Activity Database

    Harmanec, P.; Koubský, Pavel; Nemravová, J.; Royer, F.; Briot, D.; North, P.; Lampens, P.; Frémat, Y.; Yang, S.; Božić, H.; Kotková, Lenka; Škoda, Petr; Šlechta, Miroslav; Korčáková, D.; Wolf, M.; Zasche, P.

    2015-01-01

    Roč. 573, January (2015), A107/1-A107/17 ISSN 0004-6361 R&D Projects: GA ČR GD205/08/H005 Grant - others:GA ČR(CZ) GA205/06/0304; GA ČR(CZ) GAP209/10/0715 Program:GA Institutional support: RVO:67985815 Keywords : close binaries * spectroscopic * emission-line Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.378, year: 2014

  14. From Off-line to On-line Handwriting Recognition

    NARCIS (Netherlands)

    Lallican, P.; Viard-Gaudin, C.; Knerr, S.

    2004-01-01

    On-line handwriting includes more information on time order of the writing signal and on the dynamics of the writing process than off-line handwriting. Therefore, on-line recognition systems achieve higher recognition rates. This can be concluded from results reported in the literature, and has been

  15. Indigenous, colonist, and government Impacts on Nicaragua's Bosawas Reserve.

    Science.gov (United States)

    Stocks, Anthony; McMahan, Benjamin; Taber, Peter

    2007-12-01

    We studied the impacts of colonists, two groups of indigenous residents (Miskitu and Mayangna), and management by the Nicaraguan Ministry of Environment and Natural Resources (MARENA) on the forest of the Bosawas International Biosphere Reserve. Indigenous people and colonists subsist on the natural resources of the reserve, and MARENA is responsible for protecting the area from colonization and illicit exploitation. Using geostatistical procedures and Landsat images at three different time periods, we compared per capita deforestation and boundary stabilization in areas with colonists and areas with indigenous peoples. We also examined whether the Mayangna deforested less than the Miskitu and whether the Nicaraguan government has effectively defended the Bosawas boundary against the advance of the agricultural frontier. In addition, we analyzed the current distribution of land uses within the reserve and its contiguous indigenous areas with a supervised classification of current land cover. Indigenous demarcations protected the forest successfully, whereas the Bosawas boundary itself did not inhibit colonization and consequent deforestation. Indigenous farmers deforested significantly less per capita than colonists, and the two indigenous groups in Bosawas did not differ significantly in their effects on the forest. Our results show that indigenous common-property institutions and indigenous defense of homeland have been powerful factors in protecting the forests of Bosawas and that the difficult evolution of a nested cross-scale governance system in Bosawas-under pressure from indigenous peoples-is probably the key to the forest's survival thus far.

  16. Strategic production line synchronisation

    Directory of Open Access Journals (Sweden)

    Hattingh, Teresa

    2016-08-01

    Full Text Available A study was conducted at the sole global producer of suspension struts for a particular vehicle manufacturer. This supplier is currently able to meet customer demand. However, it does so because of a large finished goods and work-in-progress (WIP inventory. The plant operates two production processes that are separated by a large buffer of WIP, which essentially decouples the production processes. This study aimed to reduce this WIP buffer; this would require the processes to become synchronised, bearing in mind that the reliability of delivery should not decrease. A tool that considers time, quality, and machine capacity was developed to assess the impact of line synchronisation on company performance figures. It was found that line synchronisation produced several benefits for the supplier, including batch size reduction, lower inventory levels, and associated shorter lead times. This further allowed the supplier to improve flow in the plant by introducing a pull system. Improved visual oversight could lead to further improved problem-solving and innovation.

  17. Product Line Practice Workshop Report

    National Research Council Canada - National Science Library

    Bass, Len

    1997-01-01

    The first Software Engineering Institute Product Line Practice Workshop was a hands-on meeting held in December 1996 to share industry and government practices in software product lines and to explore...

  18. Reserve Component Programs. Fiscal Year 1999 Report of the Reserve Forces Policy Board

    Science.gov (United States)

    2000-03-01

    Heavy Equipment Truck UH-1 Helicopter AH-1 Attack Helicopter PVS-5 Night Vision Goggles Army Reserve Dolly Sets Yard Truck Maintenance Contact...border collie instead of a propane canon, and agri- cultural outsourcing with 4-H sheep grazing. The Marine Corps Reserve continues to increase

  19. Parasite infection rates of impala (Aepyceros melampus) in fenced game reserves in relation to reserve characteristics

    Science.gov (United States)

    Ezenwa, V.O.

    2004-01-01

    Under certain conditions reserves can pose a threat to wildlife conservation by increasing the transmission of parasites and pathogens. In this study, I investigated associations between reserve characteristics including area, density and species richness and parasite infection rates in impala (Aepyceros melampus). Using coprological methods to measure gastrointestinal parasitism rates of impala inhabiting five fully or partially fenced game reserves in central Kenya, I found that bovid species richness was correlated with parasite taxa richness across reserves, and that prevalence rates of multi-host strongyle nematodes were higher in reserves with more species. In addition, reserve size was also implicated as a potential predictor of infection risk. Overall, these results suggest that wildlife inhabiting highly diverse and small reserves may suffer from higher than normal rates of infection. Given the potential debilitating effects increases in parasitism can have on wildlife, these results underscore the importance of considering parasite transmission dynamics in the management of small, fenced protected areas. ?? 2003 Elsevier Ltd. All rights reserved.

  20. Cytotoxic, proapoptotic and antioxidative potential of flavonoids isolated from propolis against colon (HCT-116) and breast (MDA-MB-231) cancer cell lines.

    Science.gov (United States)

    Vukovic, Nenad L; Obradovic, Ana D; Vukic, Milena D; Jovanovic, Danijela; Djurdjevic, Predrag M

    2018-04-01

    Isolated and structurally confirmed, eleven flavonoids from propolis were examined for their cytotoxicity toward human colon cancer and human breast cancer cells. Their effect on induction of apoptosis and their antioxidative activities were also evaluated. Six flavonoids induced cytotoxic effects in both cell lines. Luteolin had a marked effect on both cell lines, especially on HCT-116 cells (IC 50 72h, 66.86μM). Also, luteolin was observed to have the highest apoptotic potential after 72h treatment of examined cell lines (27.13% and 37.09%, respectively). Myricetin exhibited selective inhibition of cell growth (IC 50 114.75μM) and induced apoptosis in MDA-MB-231 cells only. Luteolin and galangin exhibited prooxidative properties 24h after the treatment in HCT-116 cells, while myricetin induced prooxidative effects in MDA-MB-231 cells. On the other hand, selected flavonoids exhibited antioxidative properties 72h after the treatment, decreasing superoxide anion radical and nitrite levels in both cell lines. Cytotoxic and proapoptotic effects on colon and breast cancer cell lines and the influence on their redox status make tested flavonoids good candidates for developing new anticancer drugs. Copyright © 2017 Elsevier Ltd. All rights reserved.