HTR Development in China

International Nuclear Information System (INIS)

Wang Dazhong

2014-01-01

The roles of HTRs in China: 1. Due to the inherent safety features, high efficiency of electricity generation, site flexibility, the modular HTR can act as a supplement to LWR for small and medium size power generation. 2. Co-generation to supply steam up to 600℃, for petroleum refinery, oil sand and oil shale processing, sea water desalination and district heating, etc. 3. Hydrogen production at 900~1000 ℃ by V/HTR. Conclusions and prospects: • China’s energy system will experience transition and reform in the future; • Nuclear energy will play an irreplaceable role in China’s energy development; • Due to the excellent features of inherent safety, the HTR is a promising technology for electricity generation and process heat utilization; • Further international cooperation and exchanges need to be enhanced

State of the Art of helium heat exchanger development for future HTR-projects - HTR2008-58146

International Nuclear Information System (INIS)

Esch, M.; Juergens, B.; Hurtado, A.; Knoche, D.; Tietsch, W.

2008-01-01

In Germany two HTR nuclear power plants had been built and operated, the AVR-15 and the THTR-300. Also various projects for different purposes in a large power range had been developed, The AVR-15, an experimental reactor with a power output of 15 MWel was operated for more than 20 years with excellent results. The THTR-300 was designed as a prototype demonstration plant with 300 MWel and should be the technological basis for the entire future reactor line. The THTR-300 was prematurely shut down and decommissioned because of political reasons. But because of the accompanying comprehensive R and D program and the operation time of about 5 years, the technology was proved and essential operational results were gained. The AVR steam generator was installed above the reactor core. The six THTR heat exchangers were arranged circularly around the reactor core, Both heat exchanger systems have been operated successfully and furthermore acted as a residual heat removal system. The technology knowledge and experience gained on these existing HTR plants is still available at Westinghouse Electric Germany GmbH since Westinghouse is one of the legal successors of the former German HTR companies. As a follow-up project of THTR, the HTR-500 was developed and designed up to the manufacturing stage. For this plant additionally to the 8 steam generators, two residual heat removal heat exchangers were foreseen. These were to be installed in a ring around the reactor core. All these HTRs were designed for the generation of electricity using a steam cycle. Extensive research work has also been done for advanced applications of HTR technology e.g. using a direct cycle within the HHT project or generating process heat within the framework of the PNP project, Because of the critical attitude of the German government to the nuclear power in the past 20 years in Germany there was only a very limited interest in the further development of the HTR technology. As a consequence of the German

HTR-10 severe accident management

International Nuclear Information System (INIS)

Xu Yuanhui; Sun Yuliang

1997-01-01

The High Temperature Gas-cooled Reactor (HTR-10) is under construction at the Institute of Nuclear Energy Technology site northwest of Beijing. This 10 MW thermal plant utilizes a pebble bed high temperature gas cooled reactor for a large range of applications such as electricity generation, steam and district heat generation, gas turbine and steam turbine combined cycle and process heat for methane reforming. The HTR-10 is the first high temperature gas cooled reactor to be licensed in China. This paper describes the safety characteristics and design criteria for the HTR-10 as well as the accident management and analysis required for the licensing process. (author)

Régulation en génie climatique froid, climatisation, chauffage

CERN Document Server

Desmons, Jean

2010-01-01

Après un rappel des bases de l'électronique et de l'hydraulique nécessaires en régulation climatique, cet ouvrage donne tous les éléments méthodologiques et technologiques pour : concevoir les systèmes de régulation adaptés aux installations de froid, de climatisation et de chauffage ; mettre en oeuvre les régulateurs (entrées / sorties, réglage, paramétrage, dépannage, repérage et contrôle) ; pratiquer la maintenance des installations. Il regroupe notamment plusieurs cas pratiques de régulation d'installations réelles : groupe à eau glacée, bloc opératoire, pompes à chaleur, régulation numérique, détente directe, alimentation en fluide frigoporteur. Cette seconde édition révisée et mise à jour s'enrichit également d'une section sur les installations photovoltaïques et d'un nouveau chapitre sur la régulation numérique et les systèmes informatiques. Cet ouvrage constitue un outil de travail indispensable aux ingénieurs et techniciens en froid et génie climatique et en régu...

The HTR-10 project and its further development

International Nuclear Information System (INIS)

Xu Yuanhui

2002-01-01

The 10 MW High Temperature Gas-cooled Reactor-Test Module (termed as HTR-10) is one of key project in the National High Technology Research and Development Program (1986-2000). Main objectives for the HTR-10 are: (1). To acquire know-how to design, construct and operate the HTGRs, (2). To establish an experimental facility, (3). To demonstrate the inherent safety features of the Modular HTGR, (4). To test electricity and heat co-generation and closed cycle gas turbine technology and (5). To do research and development work for high temperature process heat application. The Institute of Nuclear Energy Technology (INET) of Tsinghua University was appointed as the leading institute to be responsible for design, license applications, construction and operation of the HTR-10. The HTR-10 technical design represents the features of HTR-Module design. After five years construction, installation and pre-operation the HTR-10 reached the criticality in December 2000. Up to now all of results on zero point experiments and fuel elements irradiation test are fine. China will continue to develop the high temperature gas-cooled reactor in the future using the HTR-10 base

Comparaison du filtre adaptatif RIF et du filtre a base de reseau de ...

African Journals Online (AJOL)

Comparaison du filtre adaptatif RIF et du filtre a base de reseau de neurones pour le filtrage du courant de reference pour la commande du filtre actif parallele. C Benachaiba, A Bassou, B Mazari ...

The R&D of HTGR high temperature helium sampling loop: From HTR-10 to HTR-PM

Energy Technology Data Exchange (ETDEWEB)

Fang, Chao, E-mail: fangchao@tsinghua.edu.cn [Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084 (China); Collaborative Innovation Center of Advanced Nuclear Energy Technology, Tsinghua University, Beijing 100084 (China); The Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education, Beijing 100084 (China); Bao, Xuyin; Yang, Chen; Yang, Yanran; Cao, Jianzhu [Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084 (China); Collaborative Innovation Center of Advanced Nuclear Energy Technology, Tsinghua University, Beijing 100084 (China); The Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education, Beijing 100084 (China)

2016-09-15

A High Temperature Helium Sampling Loop (HTHSL) for studying the transportation (deposition) behavior and total amount of solid fission products in high-temperature helium coming from the steam generator (SG) in the 10 MW High Temperature Gas-cooled Test Reactor (HTR-10) and High Temperature Reactor-Pebble bed Modules (HTR-PM) are researched and designed, respectively. Through the optimal design and simulation based on thermohydraulics analysis, the three-sleeve structure of deposition sampling device (DSD) could realize full-length temperature control evenly so that it could be used to study fission products in the primary circuit of HTR-10. On the other hand, an improved DSD is also designed for HTR-PM based on corresponding simulations, which could be used to sample the important nuclei in the high temperature helium from SG. These schemes offer two different methods to obtain the original source term in the high temperature helium, which will provide deeper understanding for the analysis of source terms of HTGR.

Present status of research and development for HTR in China

Energy Technology Data Exchange (ETDEWEB)

Dazhong, Wang; Daxin, Zhong; Yuanhul, Xu [Institute of Nuclear Energy Technology, Tsinghua University, Beijing (China)

1990-07-01

The HTR R and D Project is being carried out in the relevant institutions in China. Some topics are covered such as, fuel element technology, graphite development, fuel element handling system, helium technology, fuel reprocessing technology as well as HTR design study. Some results of HTR research work are described. In addition, to provide a test facility for investigation of HTR Module reactor safety and process heat application of HTR, a joint project on building a 10 MW test HTR with Siemens-Interatom, KFA Juelich and INET is going on. The conceptual design of 10 MW test HTR has been completed by the joint group. In parallel the application study of HTR Module is being carried out for the oil industry, petrochemical industry as well as power generation. Some preliminary results of the application study, for example, for heavy oil recovery on Shengli oil field and process heat application in Yan shan petroleum company, are described. (author)

Why HTR/VHTR? A European point of view

International Nuclear Information System (INIS)

Basini, V.; Bogusch, E.; Breuil, E.; Buckthorpe, D.; Chauvet, V.; Ftitterer, M.; Van Heek, A.; Hittner, D.; Von Lensa, W.; Pirson, J.; Verrier, D.

2008-01-01

The (European) High Temperature Reactor Technology Network (HTR-TN) was created in 2000 by the main industrial and Research actors of nuclear energy in Europe for elaborating a strategy for developing advanced HTR technology towards industrial application and for taking initiatives for implementing this strategy, most particularly through the Euratom funded R and D programmes. HTR-TN members are convinced that the main market push for industrial deployment of a new generation of HTR will not come from utility needs for electricity generation, but from industrial process heat needs: even if HTR can be considered for satisfying particular niches of the electricity market, there will not be any incentive for utilities already experienced in the exploitation of large LWR to take the risk of a significant technology change, when no evident competitive edge would result from it. On the contrary, HTR is the sole nuclear system that can address heat needs of a large number of industrial processes that require a higher temperature than the temperature provided by all other types of industrial reactors. The possibility for HTR to address the industrial process heat market is a strong asset, as it opens to HTR a large market which is presently looking for solutions to reduce drastically CO 2 emissions, but at the same time it is a huge challenge: industrial exploitation of nuclear energy has been for the time being focused on electricity generation for which user requirements are relatively uniform. The versatility of process heat needs in terms of power, temperature, reliability, etc. will require a much larger flexibility of the nuclear heat source, which is not usual for nuclear industry, looking for competitiveness through standardisation. Therefore HTR-TN considers that the top priority innovation for HTR present development should not be missed: it is to demonstrate at an industrial scale the technical, industrial and economical feasibility of the coupling of a HTR with

The HTR safety concept demonstrated by selected examples

International Nuclear Information System (INIS)

Sommer, H.; Stoelzl, D.

1981-01-01

The licensing experience gained in the Federal Republic of Germany is based on the licensing procedures for the THTR-300 and the HTR-1160. In the course of the licensing procedures for these reactors a safety concept for an HTR has been developed. This experience constitutes the basis for the design of future HTR's. (author)

The future of HTR development and market chances

International Nuclear Information System (INIS)

Baust, E.; Weisbrodt, I.

1989-01-01

In more than thirty years of development, the pebble bed high-temperature reactor has been brought to the threshold of commercial maturity. On the basis of the experience accumulated with the 15 MW AVR reactor and the THTR-300, unit sizes tailored to demand (HTR-500, modular HTR, GHR-10) will be developed for the electricity and heat markets of the future. The high-temperature reactor is a meaningful supplement to the proven line of light-water reactors and is particularly suitable for being exported to developing countries and industrial threshold countries because of its special technical and inherent safeguards properties. There is broad worldwide interest in the HTR, as is evidenced by several existing agreements on cooperation. It is for this reason that market chances are believed to exist for the HTR after the expected revival of the nuclear power market. ABB and Siemens therefore have decided to develop and market the HTR jointly in the future as a matter of long term strategy by working through a joint subsidiary, HTR-GmbH. (orig.) [de

HTR core physics analysis at NRG

International Nuclear Information System (INIS)

Kuijper, J.C.; Haas, J.B.M. de; Oppe, J.

2002-01-01

Since a number of years NRG is developing the HTR reactor physics code system PANTHERMIX. In PANTHERMIX the 3-D steady-state and transient core physics code PANTHER has been interfaced with the HTR thermal hydraulics code THERMIX to enable core follow and transient analyses on both pebble bed and block type HTR systems. Recently the capabilities of PANTHERMIX have been extended with the possibility to simulate the flow of pebbles through the core cavity and the (re)loading of pebbles on top of the core.The PANTHERMIX code system is being applied for the benchmark exercises for the Chinese HTR-10 and Japanese HTTR first criticality, calculating the critical loading, control rod worth and the isothermal temperature coefficients at zero power conditions. Also core physics calculations have been performed on an early version the South African PBMR design. The reactor physics properties of the reactor at equilibrium core loading have been studied as well as a selected run-in scenario, starting form fresh fuel. The recently developed reload option of PANTHERMIX was used extensively in these analyses. The examples shown demonstrate the capabilities of PANTHERMIX for performing steady-state and transient HTR core physics analyses. However, additional validation, especially for transient analyses, remains desirable. (author)

For a Global HTR Marketing Initiative

International Nuclear Information System (INIS)

Bredimas, Alexandre; Venneri, Francesco; Richards, Matthew

2014-01-01

HTRs are at a crossroads in their history. The technology is proven and the current technical developments relatively mastered but the marketing track record is disappointing. This paper comes to the conclusion that an international, collaborative marketing and communication plan must be implemented in order to address the marketing bottleneck of HTRs. The paper reflects about the HTR product specificities, its unique selling points and its positioning against other nuclear designs and gas cogeneration. It summarises the global market status and demonstrates that the global market for HTRs is there, for electricity generation, industrial cogeneration and polygeneration. The paper finally argues that HTR vendors have a shared interest to unite in order to succeed in activating the market demand for HTR, and suggests an action plan for an international collaboration among HTR vendors to market and communicate globally on HTRs and reach together a critical mass of business leads worldwide, a mutually beneficial outcome. (author)

Future Development of Modular HTGR in China after HTR-PM

International Nuclear Information System (INIS)

Zhang Zuoyi; Wang, Haitao; Dong Yujie; Li Fu

2014-01-01

The modular high temperature gas-cooled reactor (MHTGR) is an inherently safe nuclear energy technology for efficient electricity generation and process heat applications. The MHTGR is promising in China as it may replace fossil fuels in broader energy markets. In line with China’s long-term development plan of nuclear power, the Institute of Nuclear and New Energy Technology (INET) of Tsinghua University developed and designed a MHTGR demonstration plant, named high-temperature gas-cooled reactor-pebble bed module (HTR-PM). The HTR-PM came into the construction phase at the end of 2012. The HTR-PM aims to demonstrate safety, economic potential and modularization technologies towards future commercial applications. Based on experiences obtained from the HTR-PM project with respect to design, manufacture, construction, licensing and project management, a further step aiming to promote commercialization and market applications of the MHTGR is expected. To this purpose, INET is developing a commercialized MHTGR named HTR-PM600 and a conceptual design is under way accordingly. HTR-PM600 is a pebble-bed MHTGR power generation unit with a six-pack of 250MWth reactor modules. The objective is to cogenerate electricity and process heat flexibly and economically in order to meet a variety of market needs. The design of HTR-PM600 closely follows HTR-PM with respect to safety features, system configuration and plant layout. HTR-PM600 has the six modules feeding one steam turbine to generate electricity with capacity to extract high temperature steam from various interfaces of the turbine for further process heat applications. A standard plant consists of two HTR-PM600 units. Based on the economic information of HTR-PM, a preliminary study is carried out on the economic prospect of HTR-PM600. (author)

The HTR-PM Plant Full Scope Training Simulator

International Nuclear Information System (INIS)

Wang Junsan; Wang Yuding; Zhou Shuyong; Cai Ruizhong; Cao Jianting

2014-01-01

This paper describes the technical aspects of the Full Scope Training Simulator developed for HTR-PM Plant in Shidao Bay, Shandong Province, China. An overview of the HTR-PM plant and simulator structure is presented. The models developed for the simulator are discussed in detail. Some important verification tests have been conducted on the HTR-PM Plant Training Simulator. (author)

The Energy Conversion Analysis of HTR Gas Turbine System

International Nuclear Information System (INIS)

Utaja

2000-01-01

The energy conversion analysis of HTR gas turbine system by hand calculation is tedious work and need much time. This difficulty comes from the repeated thermodynamic process calculation, both on compression or expansion of the cycle. To make the analysis faster and wider variable analyzed, HTR-1 programme is used. In this paper, the energy conversion analysis of HTR gas turbine system by HTR-1 will be described. The result is displayed as efficiency curve and block diagram with the input and output temperature of the component. This HTR-1 programme is developed by Basic language programming and be compiled by Visual Basic 5.0 . By this HTR-1 programme, the efficiency, specific power and effective compression of the amount of gas can be recognized fast. For example, for CO 2 gas between 40 o C and 700 o C, the compression on maximum efficiency is 4.6 and the energy specific is 18.9 kcal/kg, while the temperature changing on input and output of the component can be traced on monitor. This process take less than one second, while the manual calculation take more than one hour. It can be concluded, that the energy conversion analysis of the HTR gas turbine system by HTR-1 can be done faster and more variable analyzed. (author)

Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains.

Directory of Open Access Journals (Sweden)

Przemyslaw Glaza

Full Text Available Human HtrA3 protease, which induces mitochondria-mediated apoptosis, can be a tumor suppressor and a potential therapeutic target in the treatment of cancer. However, there is little information about its structure and biochemical properties. HtrA3 is composed of an N-terminal domain not required for proteolytic activity, a central serine protease domain and a C-terminal PDZ domain. HtrA3S, its short natural isoform, lacks the PDZ domain which is substituted by a stretch of 7 C-terminal amino acid residues, unique for this isoform. This paper presents the crystal structure of the HtrA3 protease domain together with the PDZ domain (ΔN-HtrA3, showing that the protein forms a trimer whose protease domains are similar to those of human HtrA1 and HtrA2. The ΔN-HtrA3 PDZ domains are placed in a position intermediate between that in the flat saucer-like HtrA1 SAXS structure and the compact pyramidal HtrA2 X-ray structure. The PDZ domain interacts closely with the LB loop of the protease domain in a way not found in other human HtrAs. ΔN-HtrA3 with the PDZ removed (ΔN-HtrA3-ΔPDZ and an N-terminally truncated HtrA3S (ΔN-HtrA3S were fully active at a wide range of temperatures and their substrate affinity was not impaired. This indicates that the PDZ domain is dispensable for HtrA3 activity. As determined by size exclusion chromatography, ΔN-HtrA3 formed stable trimers while both ΔN-HtrA3-ΔPDZ and ΔN-HtrA3S were monomeric. This suggests that the presence of the PDZ domain, unlike in HtrA1 and HtrA2, influences HtrA3 trimer formation. The unique C-terminal sequence of ΔN-HtrA3S appeared to have little effect on activity and oligomerization. Additionally, we examined the cleavage specificity of ΔN-HtrA3. Results reported in this paper provide new insights into the structure and function of ΔN-HtrA3, which seems to have a unique combination of features among human HtrA proteases.

Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains.

Science.gov (United States)

Glaza, Przemyslaw; Osipiuk, Jerzy; Wenta, Tomasz; Zurawa-Janicka, Dorota; Jarzab, Miroslaw; Lesner, Adam; Banecki, Bogdan; Skorko-Glonek, Joanna; Joachimiak, Andrzej; Lipinska, Barbara

2015-01-01

Human HtrA3 protease, which induces mitochondria-mediated apoptosis, can be a tumor suppressor and a potential therapeutic target in the treatment of cancer. However, there is little information about its structure and biochemical properties. HtrA3 is composed of an N-terminal domain not required for proteolytic activity, a central serine protease domain and a C-terminal PDZ domain. HtrA3S, its short natural isoform, lacks the PDZ domain which is substituted by a stretch of 7 C-terminal amino acid residues, unique for this isoform. This paper presents the crystal structure of the HtrA3 protease domain together with the PDZ domain (ΔN-HtrA3), showing that the protein forms a trimer whose protease domains are similar to those of human HtrA1 and HtrA2. The ΔN-HtrA3 PDZ domains are placed in a position intermediate between that in the flat saucer-like HtrA1 SAXS structure and the compact pyramidal HtrA2 X-ray structure. The PDZ domain interacts closely with the LB loop of the protease domain in a way not found in other human HtrAs. ΔN-HtrA3 with the PDZ removed (ΔN-HtrA3-ΔPDZ) and an N-terminally truncated HtrA3S (ΔN-HtrA3S) were fully active at a wide range of temperatures and their substrate affinity was not impaired. This indicates that the PDZ domain is dispensable for HtrA3 activity. As determined by size exclusion chromatography, ΔN-HtrA3 formed stable trimers while both ΔN-HtrA3-ΔPDZ and ΔN-HtrA3S were monomeric. This suggests that the presence of the PDZ domain, unlike in HtrA1 and HtrA2, influences HtrA3 trimer formation. The unique C-terminal sequence of ΔN-HtrA3S appeared to have little effect on activity and oligomerization. Additionally, we examined the cleavage specificity of ΔN-HtrA3. Results reported in this paper provide new insights into the structure and function of ΔN-HtrA3, which seems to have a unique combination of features among human HtrA proteases.

Progress of the HTR-10 project

International Nuclear Information System (INIS)

Zhong, D.; Xu, Y.

1996-01-01

This paper briefly introduces the main technical features and the design specifications of the HTR-10. Present status and main progress of the license applications, the design and manufacture of the main components and the engineering experiments as well as the construction of the HTR-10 are summarized. (author). 3 tabs

International HTR activities

International Nuclear Information System (INIS)

Baust, E.; Weisbrodt, I.

1989-01-01

Asea Brown Boveri AG (ABB) and their subsidiary High Temperature Reactor Construction GmbH (HRB) have brought the pebble bed high temperature reactor to the edge of being ready for the market with the construction and operation of the AVR reactor at Juelich and the THTR 300 at Hamm-Uentrop. Siemens/Interatom have developed the HTR modular concept and, together with their partners HRB, KFA, Rheinbraun Bergbauforschung have taken the nuclear process heat project to its present advanced state of development. The further introduction of the HTR to the market is a long-term objective, due to the present market situation. ABB and Siemens AG have therefore agreed to collaborate by forming a joint company. (orig.)

A new impetus for developing industrial process heat applications of HTR in europe - HTR2008-58259

International Nuclear Information System (INIS)

Hittner, D.; De Groot, S.; Griffay, G.; Yvon, P.; Pienkowski, L.; Ruer, J.; Angulo, C.; Laquaniello, G.

2008-01-01

Due to its high operating temperature (up to 850 deg. C with present technologies, possibly higher in the longer term), and its power range (a few hundred MW), the modular HTR could address a larger scope of industrial process heat needs than other present nuclear systems. Even if HTR can contribute to competitive electricity generation, this potential for industrial heat applications is the main incentive for developing this type of reactor, as it could open to nuclear energy a large non-electricity market. However several issues must be addressed and solved successfully for HTR to actually enter the market of industrial process heat: 1) as an absolute prerequisite, to develop a strategic alliance of nuclear industry and R and D with process heat user industries. 2) to solve some key technical issues, as for instance the design of a reactor and of a coupling system flexible enough to reconcile a single reactor design with multiple applications and versatile requirements for the heat source, and the development of special adaptations of the application processes or even of new processes to fit with the assets and constraints of HTR heat supply, 3) to solve critical industrial issues such as economic competitiveness, availability and 4) to address the licensing issues raised by the conjunction of nuclear and industrial risks. In line with IAEA initiatives for supporting non-electric applications of nuclear energy and with the orientations of the SET-Plan of the European Commission, the (European) HTR Technology Network (HTR-TN) proposes a new project, together with industrial process heat user partners, to provide a first impetus to the strategic alliance between nuclear and non-nuclear industries. End user requirements will be expressed systematically on the basis of inputs from industrial partners on various types of process heat applications. These requirements will be confronted with the capabilities of the HTR heat source, in order to point out possible

Worldwide status of HTR development

International Nuclear Information System (INIS)

1978-06-01

The International Atomic Energy Agency convened a technical committee meeting on high temperature reactors (HTRs) from 12-14 Dec. 1977 at Agency Headquarters to provide a forum for the exchange of information on the status of HTR development programmes and to receive advice on the Agency programme in this field. The continuing high level of international interest in HTRs was evidenced by the participation from 11 countries and 2 organizations: Austria, Belgium, France, Federal Republic of Germany, Japan, Netherlands, Poland, Switzerland, Union of Soviet Socialist Republics, United Kingdom of Great Britain, United States of America, Commission of the European Communities, and the OECD Nuclear Energy Agency. In order to promote the continuing exchange of technical information through the offices of the IAEA, a recommendation was made that the Agency establish a standing International Working Group on High Temperature Reactors (IWGHTR). This recommendation is being implemented in 1978. Considerable information on recent progress in HTR development was present at the technical committee meeting in technical reports and in progress reports on HTR development programmes. Since this material will not be published, this summary report on the worldwide status of HTR development at the beginning of 1978 has been prepared, based primarily on information presented at the December 1977 meeting

Charges froides actives pour le calibrage des radiomètres micro ...

African Journals Online (AJOL)

Nous présentons dans ce papier une synthèse concernant la réalisation de charges froides actives à partir d'un transistor micro onde. Le but de celle-ci est de fournir une source de référence pour les radiomètres qui présentent une faible température de bruit tout en fonctionnant à température ambiante. Une présentation ...

AREVA HTR concept for near-term deployment

Energy Technology Data Exchange (ETDEWEB)

Lommers, L.J., E-mail: lewis.lommers@areva.com [AREVA Inc., 2101 Horn Rapids Road, Richland, WA 99354 (United States); Shahrokhi, F. [AREVA Inc., Lynchburg, VA (United States); Mayer, J.A. [AREVA Inc., Marlborough, MA (United States); Southworth, F.H. [AREVA Inc., Lynchburg, VA (United States)

2012-10-15

This paper introduces AREVA's High Temperature Reactor (HTR) steam cycle concept for near-term industrial deployment. Today, nuclear power primarily impacts only electricity generation. The process heat and transportation fuel sectors are completely dependent on fossil fuels. In order to impact this energy sector as rapidly as possible, AREVA has focused its HTR development effort on the steam cycle HTR concept. This reduces near-term development risk and minimizes the delay before a useful contribution to this sector of the energy economy can be realized. It also provides a stepping stone to longer term very high temperature concepts which might serve additional markets. A general description of the current AREVA steam cycle HTR concept is provided. This concept provides a flexible system capable of serving a variety of process heat and cogeneration markets in the near-term.

AREVA HTR concept for near-term deployment

International Nuclear Information System (INIS)

Lommers, L.J.; Shahrokhi, F.; Mayer, J.A.; Southworth, F.H.

2012-01-01

This paper introduces AREVA's High Temperature Reactor (HTR) steam cycle concept for near-term industrial deployment. Today, nuclear power primarily impacts only electricity generation. The process heat and transportation fuel sectors are completely dependent on fossil fuels. In order to impact this energy sector as rapidly as possible, AREVA has focused its HTR development effort on the steam cycle HTR concept. This reduces near-term development risk and minimizes the delay before a useful contribution to this sector of the energy economy can be realized. It also provides a stepping stone to longer term very high temperature concepts which might serve additional markets. A general description of the current AREVA steam cycle HTR concept is provided. This concept provides a flexible system capable of serving a variety of process heat and cogeneration markets in the near-term.

Risk assessment of small-sized HTR with pebble-bed core

International Nuclear Information System (INIS)

Kroeger, W.; Mertens, J.; Wolters, J.

1987-01-01

Two recent concepts of small-sized HTR's (HTR-Modul and HTR-100) were analysed regarding their safety concepts and risk protection. In neither case do core cooling accidents contribute to the risk because of the low induced core temperatures. Water ingress accidents dominate the risk in both cases by detaching deposited fission products which can be released into the environment. For these accident sequences no early fatalities and practically no lethal case of cancer were computed. Both HTR concepts include adequate precautionary measures and an infinitely small risk according to the usual standards. The safety concepts make express use of the specific inherent safety features of pebble-bed HTR's. (orig.)

HTR plus modern turbine technology for higher efficiencies

International Nuclear Information System (INIS)

Barnert, H.; Kugeler, K.

1996-01-01

The recent efficiency race for natural gas fired power plants with gas-plus steam-turbine-cycle, is shortly reviewed. The question 'can the HTR compete with high efficiencies?' is answered: Yes, it can - in principle. The gas-plus steam-turbine cycle, also called combi-cycle, is proposed to be taken into consideration here. A comparative study on the efficiency potential is made; it yields 54.5% at 1,050 deg. C gas turbine-inlet temperature. The mechanisms of release versus temperature in the HTR are summarized from the safety report of the HTR MODUL. A short reference is made to the experiences from the HTR-Helium Turbine Project HHT, which was performed in the Federal Republic of Germany in 1968 to 1981. (author). 8 figs,. 1 tab

HTR plus modern turbine technology for higher efficiencies

Energy Technology Data Exchange (ETDEWEB)

Barnert, H; Kugeler, K [Forschungszentrum Juelich GmbH (Germany). Inst. fuer Sicherheitsforschung und Reaktortechnik

1996-08-01

The recent efficiency race for natural gas fired power plants with gas-plus steam-turbine-cycle, is shortly reviewed. The question `can the HTR compete with high efficiencies?` is answered: Yes, it can - in principle. The gas-plus steam-turbine cycle, also called combi-cycle, is proposed to be taken into consideration here. A comparative study on the efficiency potential is made; it yields 54.5% at 1,050 deg. C gas turbine-inlet temperature. The mechanisms of release versus temperature in the HTR are summarized from the safety report of the HTR MODUL. A short reference is made to the experiences from the HTR-Helium Turbine Project HHT, which was performed in the Federal Republic of Germany in 1968 to 1981. (author). 8 figs,. 1 tab.

Verification test of control rod system for HTR-10

International Nuclear Information System (INIS)

Zhou Huizhong; Diao Xingzhong; Huang Zhiyong; Cao Li; Yang Nianzu

2002-01-01

There are 10 sets of control rods and driving devices in 10 MW High Temperature Gas-cooled Test Reactor (HTR-10). The control rod system is the controlling and shutdown system of HTR-10, which is designed for reactor criticality, operation, and shutdown. In order to guarantee technical feasibility, a series of verification tests were performed, including room temperature test, thermal test, test after control rod system installed in HTR-10, and test of control rod system before HTR-10 first criticality. All the tests data showed that driving devices working well, control rods running smoothly up and down, random position settling well, and exactly position indicating

L'embouteillage stérile a froid des vins tranquilles, perlés et mousseux

Directory of Open Access Journals (Sweden)

H. MULLER-SPATH

1971-12-01

Les considérations qui vont suivre se rapportent principalement à l'embouteillage stérile à froid après filtration sur plaques stérilisantes éliminant totalement les levures et les bactéries susceptibles de provoquer l'altération du vin en bouteille.

Capital costs of modular HTR reactors

International Nuclear Information System (INIS)

Kugeler, K.; Froehling, W.

1993-01-01

A decisive factor in the introduction of a reactor line, in addition of its safety, which should exclude releases of radioactivity into the environment, is its economic development and, consequently, its competitiveness. The costs of the pressurized water reactor are used for comparison with the modular HTR reactor. If the measures proposed for evolutionary increases in safety of the PWR are taken, cost increases will have to be expected for that line. The modular HTR can now attain specific construction costs of 3000 deutschmarks per electric kilowatt. Mass production and the introduction of cost-reducing innovations can improve the economy of this line even further. In this way, the modular HTR concept offers the possibility to vendors and operators to set up new economic yardsticks in safety technology. (orig.) [de

HTR-TN achievements and prospects for future developments

International Nuclear Information System (INIS)

Hittner, D.; Angulo, C.; Basini, V.; Bogusch, E.; Breuil, E.; Buckthorpe, D.; Chauvet, V.; Futterer, M.A.; Van Heek, A.; Von Lensa, W.; Yvon, P.

2011-01-01

It is already 10 years since the (European) High Temperature Reactor Technology Network (HTR-TN) launched a program for development of HTR technology, which expanded through three successive Euratom framework programs, with many projects in line with the network strategy. Widely relying in the beginning on the legacy of the former European HTR developments (DRAGON, AVR, THTR, etc.) that it contributed to safeguard, this program led to advances in HTR/VHTR technologies and produced significant results, which can contribute to the international cooperation through Euratom involvement in the Generation IV International Forum (GIF). the main achievements of the European program, performed in complement to efforts made in several European countries and other GIF partners, are presented: they concern the validation of computer codes (reactor physics, as well as system transient analysis from normal operation to air ingress accident and fuel performance in normal and accident conditions), materials (metallic materials for vessel, direct cycle turbines and intermediate heat exchanger, graphite, etc.), component development, fuel manufacturing and irradiation behavior, and specific HTR waste management (fuel and graphite). Key experiments have been performed or are still ongoing, like irradiation of graphite and of fuel material (PYCASSO experiment), high burn-up fuel PIE, safety test and isotopic analysis, IHX mock-up thermohydraulic test in helium atmosphere, air ingress experiment for a block type core, etc. Now HTR-TN partners consider that it is time for Europe to go a step forward toward industrial demonstration. In line with the orientations of the 'Strategic Energy Technology Plan (SET-Plan)' recently issued by the European Commission that promotes a strategy for development of low-carbon energy technologies and mentions Generation IV nuclear systems as part of key technologies, HTR-TN proposes to launch a program for extending the contribution of nuclear energy to

Financing models for HTR plants: Co-financing, counter trade, joint ventures

International Nuclear Information System (INIS)

Bogen, J.; Stoelzl, D.

1987-01-01

Structure and volume of investment cost for HTR nuclear power plants are different in comparison to other types of nuclear power plants. Even if the share of local participation is in comparable order of magnitude to other nuclear power plants, the required technical infrastructure for HTR plants is more suitable for existing and still practised technologies in countries which are in development processes. These HTR specific features offer special possibilities in HTR project financing. Various models are discussed in respect of the special HTR situation. Even if it is not possible to point out in a general manner the best solution - due to national, local and time dependant situations - this paper discusses the HTR specific impacts to buyer's credit financing, supplier's credit financing, barter trades or joint ventures and combined financing. (author). 4 refs, 9 figs

Development of digital I&C system in HTR-PM

International Nuclear Information System (INIS)

Shi Guilian

2014-01-01

Conclusions: HTR-PM DCS has been under execution for 5 years( 2009-2014) . It has taken CTEC 150 man/year so far. With close cooperation with INET, Chinergyand Shanghai Electric, CTEC overcame difficulties, like iterative design, voluminous customization work, new technology, and lacking of drawings. However, the accomplishment of the planned milestones prepared CTEC for the following work in HTR-PM DCS. 1. The 1ST integrated DCS, including safety DCS, non-safety DCS, DEH supplied by Chinese supplier. Rod control system and DEH are integrated in non-safety DCS. Simplified interface, integrated platform, and easy to use and maintenance. 2. CTEC obtained knowledge of 4th generation HTR-PM digital I&C, key design technology, and riched its DCS products by participation in HTRPM. HTR-PM Safety DCS project provided valuable experience for CTEC’s development and application of FIRMSYS, a safety protection control system platform. 3. The qualification solution by customized HTR-PM safety DCS prototype helps simply safety DCS design, V&V, qualification and safety review of the actual system, but results in some problems in system upgrade and maintenance. With the satisfactory application of FIRMSYS in 1000mw PWR and platform qualification , the future HTR-PM safety DCS could be provided based on a qualified safety DCS platform.

Introduction of HTR-PM Operation and Fuel Management System

International Nuclear Information System (INIS)

Liu Fucheng; Luo Yong; Gao Qiang

2014-01-01

There is a big difference between High Temperature Gas-cooled Reactor Pebble-modules Demonstration Project(HTR-PM) and PWR in operation mode. HTR-PM is a continually refuelled reactor, and the operation and fuel management of it, which affect each other, are inseparable. Therefore, the analysis of HTR-PM fuel management needs to be carried out “in real time”. HTR-PM operation and fuel management system is developed for on-power refuelling mode of HTR-PM. The system, which calculates the core neutron flux and power distribution, taking high-temperature reactor physics analysis software-VSOP as a basic tool, can track and predict the core state online, and it has the ability to restructure core power distribution online, making use of ex-core detectors to correct and check tracking calculation. Based on the ability to track and predict, it can compute the core parameters to provide support for the operation of the reactor. It can also predict the operation parameters of the reactor to provide reference information for the fuel management.The contents of this paper include the development purposes, architecture, the main function modules, running process, and the idea of how to use the system to carry out HTR-PM fuel management. (author)

On Power Refueling Management of HTR-PM

International Nuclear Information System (INIS)

Sun Furui; Luo Yong; Gao Qiang

2014-01-01

The refueling management is an important work of nuclear power plant , directly affecting its safety and economy. At present, the ordinary commercial pressurized water reactor (PWR) nuclear power plant has developed more mature in the refueling management, and formed a set of relatively complete system and methods.The High Temperature Gas-cooled Reactor Pebble-modules Demonstration Project(HTR-PM) has significant differences with the ordinary PWR nuclear power plant in the fuel morphology and the refueling mode. It adopts the spherical fuel element and the on-power refueling. Therefore, the HTR-PM refueling management has its own unique characteristics, but currently there is no mature experience to use for reference across the world. This paper gives a brief introduction to the HTR-PM on power refueling management, including the refueling management system construction, the refueling strategy, the fuel element internal transportation,charging and discharging, etc. It aims at finding the befitting HTR-PM refueling management methods in view of its own unique characteristics in order to ensure the orderly development of the refueling management and the refueling safety. (author)

KWU's modular approach to HTR commercialization

International Nuclear Information System (INIS)

Frewer, H.; Weisbrodt, I.

1983-01-01

As a way of avoiding the uncertainties, delays and unacceptable commercial risks which have plagued advanced reactor projects in Germany, KWU is advocating a modular approach to commercialization of the high-temperature reactor (HTR), using small size standard reactor units. KWU has received a contract for the study of a co-generation plant based on this modular system. Features of the KWU modular HTR, process heat, gasification, costs and future development are discussed. (UK)

Neutron cooling and cold-neutron sources (1962); Refroidissement des neutrons et sources de neutrons froids (1962)

Energy Technology Data Exchange (ETDEWEB)

Jacrot, B [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1962-07-01

Intense cold-neutron sources are useful in studying solids by the inelastic scattering of neutrons. The paper presents a general survey covering the following aspects: a) theoretical considerations put forward by various authors regarding thermalization processes at very low temperatures; b) the experiments that have been carried out in numerous laboratories with a view to comparing the different moderators that can be used; c) the cold neutron sources that have actually been produced in reactors up to the present time, and the results obtained with them. (author) [French] Des sources intenses de neutrons froids sont utiles pour l'etude des solides par diffusion inelastique des neutrons. On presente une revue d'ensemble: a) des considerations theoriques faites par divers auteurs sur les processus de thermalisation a tres basse temperature; b) des experiences faites dans de nombreux laboratoires pour comparer les divers moderateurs possibles; c) des sources de neutrons froids effectivement realisees dans des piles a ce jour, et des resultats obtenus avec ces sources. (auteur)

Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia

NARCIS (Netherlands)

Al Hadithy, A. F. Y.; Ivanova, S. A.; Pechlivanoglou, P.; Semke, A.; Fedorenko, O.; Kornetova, E.; Ryadovaya, L.; Brouwers, J. R. B. J.; Wilffert, B.; Bruggeman, R.; Loonen, A. J. M.

2009-01-01

Background: Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians. Purpose: To investigate the association between orofaciolingual (TDof) and limb-truncal dyskinesias (TDlt) and

Development and Reliability Analysis of HTR-PM Reactor Protection System

International Nuclear Information System (INIS)

Li Duo; Guo Chao; Xiong Huasheng

2014-01-01

High Temperature Gas-Cooled Reactor-Pebble bed Module (HTR-PM) digital Reactor Protection System (RPS) is a dedicated system, which is designed and developed according to HTR-PM NPP protection specifications. To decrease the probability of accident trips and increase the system reliability, HTR-PM RPS has such features as a framework of four redundant channels, two diverse sub-systems in each channel, and two level two-out-of-four logic voters. Reliability analysis of HTR-PM RPS is based on fault tree model. A fault tree is built based on HTR-PM RPS Failure Modes and Effects Analysis (FMEA), and special analysis is focused on the sub-tree of redundant channel ''2-out-of-4'' logic and the fault tree under one channel is bypassed. The qualitative analysis of fault tree, such as RPS weakness according to minimal cut sets, is summarized in the paper. (author)

Licensing experience of the HTR-10 test reactor

International Nuclear Information System (INIS)

Sun, Y.; Xu, Y.

1996-01-01

A 10MW high temperature gas-cooled test reactor (HTR-10) is now being projected by the Institute of Nuclear Energy Technology within China's National High Technology Programme. The Construction Permit of HTR-10 was issued by the Chinese nuclear licensing authority around the end of 1994 after a period of about one year of safety review of the reactor design. HTR-10 is the first high temperature gas-cooled reactor (HTGR) to be constructed in China. The purpose of this test reactor project is to test and demonstrate the technology and safety features of the advanced modular high temperature reactor design. The reactor uses spherical fuel elements with coated fuel particles. The reactor unit and the steam generator unit are arranged in a ''side-by-side'' way. Maximum fuel temperature under the accident condition of a complete loss of coolant is limited to values much lower than the safety limit set for the fuel element. Since the philosophy of the technical and safety design of HTR-10 comes from the high temperature modular reactor design, the reactor is also called the Test Module. HTR-10 represents among others also a licensing challenge. On the one side, it is the first helium reactor in China, and there are less licensing experiences both for the regulator and for the designer. On the other side, the reactor design incorporates many advanced design features in the direction of passive or inherent safety, and it is presently a world-wide issue how to treat properly the passive or inherent safety design features in the licensing safety review. In this presentation, the licensing criteria of HTR-10 are discussed. The organization and activities of the safety review for the construction permit licensing are described. Some of the main safety issues in the licensing procedure are addressed. Among these are, for example, fuel element behaviour, source term, safety classification of systems and components, containment design. The licensing experiences of HTR-10 are of

Reactor physics calculations on the Dutch small HTR concept

International Nuclear Information System (INIS)

Kuijper, J.C.; Haas, J.B.M. de; Klippel, H.T.; Hogenbirk, A.; Oppe, J.; Sciolla, C.M.; Stad, R.C.L. van der; Zhang, B.C.

1997-06-01

As part of the activities within the framework of the development of INCOGEN, a 'Dutch' conceptual design of a smaller HTR, the ECN reactor physics code system has been extended with the capability to perform combined neutronics and thermal hydraulics steady-state, burnup and transient core calculations on pebble-bed type HTRs, by joining the general purpose reactor code PANTHER and the HTR thermal hydraulics code THERMIX/DIREKT in the PANTHERMIX code combination. The validation of the ECN code system for HTR applications is still in progress, but some promising first calculation results on unit cell and whole core geometries are presented, which indicate that the extended ECN code system is quite suitable for performing the pebble-bed HTR core calculations, required in the INCOGEN core design and optimization process. (orig.)

Reactor physics calculations on the Dutch small HTR concept

International Nuclear Information System (INIS)

Kuijper, J.C.; Hass, J.B.M. De; Klippel, H.Th.; Hogenbirk, A.; Oppe, J.; Sciolla, C.; Stad, R.C.L. Van Der; Zhang, B.C.

1997-01-01

As part of the activities within the framework of the development of INCOGEN, a ''Dutch'' conceptual design of a small HTR, the ECN reactor physics code system has been extended with the capability to perform combined neutronics and thermal hydraulics steady-state, burnup and transient core calculations on pebble-bed type HTRS, by joining the general purpose reactor code PANTHER and the HTR thermal hydraulics code THERMIX/DIREKT in the PANTHERMIX code combination. The validation of the ECN code system for HTR applications is still in progress, but some promising first calculation results on unit cell and whole core geometries are presented, which indicate that the extended ECN code system is quite suitable for performing the pebble-bed HTR core calculations, required in the INCOGEN core design and optimization process. (author)

Preparation of spherical fuel elements for HTR-PM in INET

International Nuclear Information System (INIS)

Xiangwen, Zhou; Zhenming, Lu; Jie, Zhang; Bing, Liu; Yanwen, Zou; Chunhe, Tang; Yaping, Tang

2013-01-01

Highlights: • Modifications and optimizations in the manufacture of spherical fuel elements (SFE) for HTR-PM are presented. • A newly developed overcoater exhibits good stability and high efficiency in the preparation of overcoated particles. • The optimized carbonization process reduces the process time from 70 h in the period of HTR-10 to 20 h. • Properties of the prepared SFE and matrix graphite balls meet the design specifications for HTR-PM. • In particular the mean free uranium fraction of 5 consecutive batches is only 8.7 × 10 −6 . -- Abstract: The spherical fuel elements were successfully manufactured in the period of HTR-10. In order to satisfy the mass production of fuel elements for HTR-PM, several measures have been taken in modifying and optimizing the manufacture process of fuel elements. The newly developed overcoater system and its corresponding parameters exhibited good stability and high efficiency in the preparation of overcoated particles. The optimized carbonization process could reduce the carbonization time from more than 70 h to 20 h and improve the manufacturing efficiency. Properties of the manufactured spherical fuel elements and matrix graphite balls met the design specifications for HTR-PM. The mean free uranium fraction of 5 consecutive batches was 8.7 × 10 −6 . The optimized fuel elements manufacturing process could meet the requirements of design specifications of spherical fuel elements for HTR-PM

Notes on HTR applications in methanol production

International Nuclear Information System (INIS)

Santoso, B.; Barnert, H.

1997-01-01

Notes on the study of HTR applications are presented. The study in particular should be directed toward the most feasible applications of HTR for process heat generation. A prospective study is the conversion of CO 2 gas from Natuna to methanol or formic acid. Further studies needs to be deepened under the auspices of IAEA and countries that have similar interest. (author). 3 refs, 3 figs

Instrumentation of steam cycle HTR's up to 900 MWe

International Nuclear Information System (INIS)

Leithner, D.E.; Winkenbach, B.

1982-06-01

Due to basic design features and inherent safety qualities in-core instrumentation is not needed in an HTR. Reactor safety requirements can be met by integral measurements. A modest spatial resolving power of the out-of-core instrumentation is sufficient for all operational purposes in small and medium sized steam cycle HTR's. Thus, the instrumentation concept of the THTR 300 MWe prototype reactor can be adopted without major changes for the HTR 450 MWe reactor project, as is demonstrated here for the neutron flux and temperature measurements. (author)

HTR-PM Progress and Further Commercial Deployment

International Nuclear Information System (INIS)

Wu, Frank

2017-01-01

Project Milestones: • 2004: industry investment agreement was signed • 2006: decided to use 2×250 MWt reactor modules with a 200 MWe steam turbine, became a key government R&D project • 2008: ATP was issued • 2012.12.9: FCD the first concrete poured. Chinese HTR development: HTR Roles in China - Power generation: supplement to LWR; repowering coal fired plants - Co-generation to supply steam - Hydrogen production

EC-funded project (HTR-L) for the definition of a European safety approach for HTR's

International Nuclear Information System (INIS)

Ehster, S.; Dominguez, M.T.; Coe, I.; Brinkmann, G.; Lensa, W. von; Mheen, W. van der; Alessandroni, C.; Pirson, J.

2002-01-01

The inherent safety features of the HTRs make events leading to severe core damage highly unlikely and constitute the main differentiating aspects compared to LWRs. While a known and stable regulatory environment has long been established for Light Water Reactors, a different approach is necessary for the licensing of HTR based power plants. Among the R and D projects funded by the European Commission for HTR reactors, the HTR-L project is dedicated to the definition of a common and coherent European safety approach and the identification of the main licensing issues for the licensing framework of the Modular HTRs. Other specific objectives of this project are : To develop a methodology to classify the accidental conditions; To define the preliminary requirements for the confinement of radioactive products and to assess the need for a 'conventional' containment structure; To establish a SSC (2) classification and to define the rules for equipment qualification; To identify the key issues that need to be addressed in the licensing process of the HTRs; To organize a workshop with the concerned Safety Authorities at the end of the project. This paper will explain the project objectives and its final expected outcomes. (author)

Vagal innervation is required for pulmonary function phenotype in Htr4-/- mice.

Science.gov (United States)

House, John S; Nichols, Cody E; Li, Huiling; Brandenberger, Christina; Virgincar, Rohan S; DeGraff, Laura M; Driehuys, Bastiaan; Zeldin, Darryl C; London, Stephanie J

2017-04-01

Human genome-wide association studies have identified over 50 loci associated with pulmonary function and related phenotypes, yet follow-up studies to determine causal genes or variants are rare. Single nucleotide polymorphisms in serotonin receptor 4 ( HTR4 ) are associated with human pulmonary function in genome-wide association studies and follow-up animal work has demonstrated that Htr4 is causally associated with pulmonary function in mice, although the precise mechanisms were not identified. We sought to elucidate the role of neural innervation and pulmonary architecture in the lung phenotype of Htr4 -/- animals. We report here that the Htr4 -/- phenotype in mouse is dependent on vagal innervation to the lung. Both ex vivo tracheal ring reactivity and in vivo flexiVent pulmonary functional analyses demonstrate that vagotomy abrogates the Htr4 -/- airway hyperresponsiveness phenotype. Hyperpolarized 3 He gas magnetic resonance imaging and stereological assessment of wild-type and Htr4 -/- mice reveal no observable differences in lung volume, inflation characteristics, or pulmonary microarchitecture. Finally, control of breathing experiments reveal substantive differences in baseline breathing characteristics between mice with/without functional HTR4 in breathing frequency, relaxation time, flow rate, minute volume, time of inspiration and expiration and breathing pauses. These results suggest that HTR4's role in pulmonary function likely relates to neural innervation and control of breathing. Copyright © 2017 the American Physiological Society.

Status of development of the HTR module

International Nuclear Information System (INIS)

Weisbrodt, I.A.

1989-01-01

Growing concern about the rising global temperature of the earth due to the ''Greenhouse Effect'' is increasingly focussing worldwide interest on passively safe reactors for heat and power production. In this context the development status of the HTR-Module designed by the Siemens-Group merits strong interest. The HTR-Module has a high degree of passive safety features. Even in case of hypothetical accidents the decay heat is dissipated from the primary system to the environment by passive measures alone i.e. by heat conduction, convection and radiation. The detailed engineering for the HTR-Module continues to progress. In addition to the engineering for the layout considerable progress has been made in the detailed engineering for specific components - e.g. pressure vessel, steam generator, hot gas duct, blower etc. - and specific systems - e.g. first core, helium purification system, reactor safety system, reactor control etc. The procedure for the conceptual licence has been continued. A large number of supplementary analyses and reports have been elaborated and submitted for this procedure. Many workshop meetings have been held with the nominated experts. The hypothetical accidents have been analysed and a special report on these accidents has been submitted. The safety analyses report has been revised, taking into account the results and achievements reached during the ongoing licensing procedure. Parallel to these engineering activities outstanding in R and D work for the HTR-Module, e.g. in the field of fuel elements etc. has been continued. The HTR-Module has found worldwide interest. Respective activities are going on in Bangladesh, PR China, USSR, Indonesia etc. Relevant application studies have been carried out and/or initiated. (author). 15 refs, 16 figs

An HTR cogeneration system for industrial applications

International Nuclear Information System (INIS)

Haverkate, B.R.W.; Heek, A.I. van; Kikstra, J.F.

2001-01-01

Because of its favourable characteristics of safety and simplicity the high-temperature reactor (HTR) could become a competitive heat source for a cogeneration unit. The Netherlands is a world leading country in the field of cogeneration. As nuclear energy remains an option for the medium and long term in this country, systems for nuclear cogeneration should be explored and developed. Hence, ECN Nuclear Research is developing a conceptual design of an HTR for Combined generation of Heat and Power (CHP) for the industry in and outside the Netherlands. The design of this small CHP-unit for industrial applications is mainly based on a pre-feasibility study in 1996, performed by a joint working group of five Dutch organisations, in which technical feasibility was shown. The concept that was subject of this study, INCOGEN, used a 40 MW thermal pebble bed HTR and produced a maximum amount of electricity plus low temperature heat. The system has been improved to produce industrial quality heat, and has been renamed ACACIA. The output of this installation is 14 MW electricity and 17 tonnes of steam per hour, with a pressure of 10 bar and a temperature of 220 deg. C. The economic characteristics of this installation turned out to be much more favourable using modern data. The research work for this installation is embedded in a programme that has links to the major HTR projects in the world. Accordingly ECN participates in several IAEA Co-ordinated Research Programmes (CRPs). Besides this, ECN is involved in the South African PBMR-project. Finally, ECN participates in the European Concerted Action on Innovative HTR. (author)

HTR-10GT AMBs displacement sensor design

International Nuclear Information System (INIS)

Shi Zhengang; Zha Meisheng; Zhao Lei; Sun Zhuo

2005-01-01

The 10 MW high temperature gas-cooled test module reactor (HTR-10GT) with the core made of spherical fuel elements was designed and constructed by the Institute of Nuclear and New Energy Technology of Tsinghua University in China. In the HTR-10GT, turbo-compressor and generator rotors are connected by a flexible coupling. The rotors, restricted by actual instruments and working environment, must be supported without any contact and lubrication. Active magnetic bearing (AMB), known as its advantages over the conventional bearings., such as contact-free, no-lubricating and active damping vibration, is the best way to suspend and stabilize the position of rotors of HTR-10GT. Each rotor is suspended by two radial and one axial AMBs. The radial AMB's radial gap is 0.15 mm considering the gap of 0.4 mm between the compressor stator and blades in order to protect the compressor. The control system controls the rotor position to meet the required gaps between rotor and stator through windings current. All the position information concerning radial and axial AMB is generated by sensors for measuring the displacement of the levitated body. Some typical sensors, i.e. eddy current displacement sensor, capacitive displacement sensor, can provide position information, but, quite often, unsatisfactory anti-jamming, which is a key issue for AMB systems near generator and other electric devices in HTR-10GT. Therefore, a kind of new type sensor is designed to measure the radial and axial displacements and the vibration of the rotors. This paper focuses on the design characteristics of the HTR-10GT AMBs displacement sensors and introduction of the related experiments to demonstrate its performance. (authors)

State of the art in HTR engineering and design

International Nuclear Information System (INIS)

Baust, E.

1984-11-01

The high-temperature reactor is an universally applicable energy source on the electricity and heat market, providing energy safely, compatible with the environment, and economically. The startup of the THTR-300, which will commence power generation in spring 1985, and the good results of the preparatory tests and studies for the subsequent plant, the HTR-500, created the required preconditions for the placing of an order to commence work to realize the first planning stage of the HTR-500. The order is expected to be placed within short. BBC/HRB has gained a reputation worldwide as the leading manufacturer of HTR plants. BBC/HRB has the know-how to offer HTR plants of various size over the entire capacity range between 100 and 600 MWe, or as twin-type plants up to 1200 MWe, their design being based on the THTR-300 reference plant. The HTR is an uncomplicated reactor system offering many advantages in terms of operation and safety. This reactor type therefore is the system of choice for energy generation for short-range energy supply. The system also is of interest as an export item, and hence is of significance to the economy and to employment policy. (orig.) [de

Tritium in HTR systems

International Nuclear Information System (INIS)

Steinwarz, W.

1987-07-01

Starting from the basis of the radiological properties of tritium, the provisions of present-day radiation protection legislation are discussed in the context of the handling of this radionuclide in HTR plants. Tritium transportation is then followed through from the place of its creation up until the sink, i.e. disposal and/or environmental route, and empirical values obtained in experiments and in plant operation translated into guidelines for plant design and planning. The use of the example of modular HTR plants permits indication that environmental contamination via the 'classical' routes of air and water emissions, and contamination of products, and resulting consumer exposure, are extremely low even on the assumption of extreme conditions. This leads finally to a requirement that the expenditure for implementation of measures for further reduction of tritium activity rates be measured against low radiological effect. (orig.) [de

Overview of Japanese seismic research program for HTR

International Nuclear Information System (INIS)

Ikushima, Takeshi

1978-07-01

In order to obtain the license for construction and operation of HTR developed and introduced into Japan, it is necessary to assure integrity of reactor structures and the capability of reactor shutdown and maintain safety shutdown for the seismic design condition. Because Japanese land is located in relatively high seismacity zone, when an excessive earthquake would occur, the public and plant personnel should be protected from radiation hazard. For the above reason, many efforts of seismic research and development for HTR have been made at institutes and companies in Japan. In the paper, descriptions are: (1) Present status of development and construction plans of HTR, (2) guideline of aseismic design, (3) need of aseismic research, (4) present status of research and development, (5) future plan. (auth.)

The nucleus accumbens 5-HTR4-CART pathway ties anorexia to hyperactivity

Science.gov (United States)

Jean, A; Laurent, L; Bockaert, J; Charnay, Y; Dusticier, N; Nieoullon, A; Barrot, M; Neve, R; Compan, V

2012-01-01

In mental diseases, the brain does not systematically adjust motor activity to feeding. Probably, the most outlined example is the association between hyperactivity and anorexia in Anorexia nervosa. The neural underpinnings of this ‘paradox', however, are poorly elucidated. Although anorexia and hyperactivity prevail over self-preservation, both symptoms rarely exist independently, suggesting commonalities in neural pathways, most likely in the reward system. We previously discovered an addictive molecular facet of anorexia, involving production, in the nucleus accumbens (NAc), of the same transcripts stimulated in response to cocaine and amphetamine (CART) upon stimulation of the 5-HT4 receptors (5-HTR4) or MDMA (ecstasy). Here, we tested whether this pathway predisposes not only to anorexia but also to hyperactivity. Following food restriction, mice are expected to overeat. However, selecting hyperactive and addiction-related animal models, we observed that mice lacking 5-HTR1B self-imposed food restriction after deprivation and still displayed anorexia and hyperactivity after ecstasy. Decryption of the mechanisms showed a gain-of-function of 5-HTR4 in the absence of 5-HTR1B, associated with CART surplus in the NAc and not in other brain areas. NAc-5-HTR4 overexpression upregulated NAc-CART, provoked anorexia and hyperactivity. NAc-5-HTR4 knockdown or blockade reduced ecstasy-induced hyperactivity. Finally, NAc-CART knockdown suppressed hyperactivity upon stimulation of the NAc-5-HTR4. Additionally, inactivating NAc-5-HTR4 suppressed ecstasy's preference, strengthening the rewarding facet of anorexia. In conclusion, the NAc-5-HTR4/CART pathway establishes a ‘tight-junction' between anorexia and hyperactivity, suggesting the existence of a primary functional unit susceptible to limit overeating associated with resting following homeostasis rules. PMID:23233022

The chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosol

Directory of Open Access Journals (Sweden)

Flores Rhonda

2011-04-01

Full Text Available Abstract Background The periplasmic High Temperature Requirement protein A (HtrA plays important roles in bacterial protein folding and stress responses. However, the role of chlamydial HtrA (cHtrA in chlamydial pathogenesis is not clear. Results The cHtrA was detected both inside and outside the chlamydial inclusions. The detection was specific since both polyclonal and monoclonal anti-cHtrA antibodies revealed similar intracellular labeling patterns that were only removed by absorption with cHtrA but not control fusion proteins. In a Western blot assay, the anti-cHtrA antibodies detected the endogenous cHtrA in Chlamydia-infected cells without cross-reacting with any other chlamydial or host cell antigens. Fractionation of the infected cells revealed cHtrA in the host cell cytosol fraction. The periplasmic cHtrA protein appeared to be actively secreted into host cell cytosol since no other chlamydial periplasmic proteins were detected in the host cell cytoplasm. Most chlamydial species secreted cHtrA into host cell cytosol and the secretion was not inhibitable by a type III secretion inhibitor. Conclusion Since it is hypothesized that chlamydial organisms possess a proteolysis strategy to manipulate host cell signaling pathways, secretion of the serine protease cHtrA into host cell cytosol suggests that the periplasmic cHtrA may also play an important role in chlamydial interactions with host cells.

Serotonergic gene polymorphisms (5-HTTLPR, 5HTR1A, 5HTR2A), and population differences in aggression: traditional (Hadza and Datoga) and industrial (Russians) populations compared.

Science.gov (United States)

Butovskaya, Marina L; Butovskaya, Polina R; Vasilyev, Vasiliy A; Sukhodolskaya, Jane M; Fekhredtinova, Dania I; Karelin, Dmitri V; Fedenok, Julia N; Mabulla, Audax Z P; Ryskov, Alexey P; Lazebny, Oleg E

2018-04-16

Current knowledge on genetic basis of aggressive behavior is still contradictory. This may be due to the fact that the majority of studies targeting associations between candidate genes and aggression are conducted on industrial societies and mainly dealing with various types of psychopathology and disorders. Because of that, our study was carried on healthy adult individuals of both sex (n = 853). Three populations were examined: two traditional (Hadza and Datoga) and one industrial (Russians), and the association of aggression with the following polymorphisms 5-HTTLPR, rs6295 (5HTR1A gene), and rs6311 (5HTR2A gene) were tested. Aggression was measured as total self-ratings on Buss-Perry Aggression Questionnaire. Distributions of allelic frequencies of 5-HTTLPR and 5HTR1A polymorphisms were significantly different among the three populations. Consequently, the association analyses for these two candidate genes were carried out separately for each population, while for the 5HTR2A polymorphism, it was conducted on the pooled data that made possible to introduce ethnic factor in the ANOVA model. The traditional biometrical approach revealed no sex differences in total aggression in all three samples. The three-way ANOVA (μ + 5-HTTLPR + 5HTR1A + 5HTR2A +ε) with measures of self-reported total aggression as dependent variable revealed significant effect of the second serotonin receptor gene polymorphism for the Hadza sample. For the Datoga, the interaction effect between 5-HTTLPR and 5HTR1A was significant. No significant effects of the used polymorphisms were obtained for Russians. The results of two-way ANOVA with ethnicity and the 5HTR2A polymorphism as main effects and their interactions revealed the highly significant effect of ethnicity, 5HTR2A polymorphism, and their interaction on total aggression. Our data provided obvious confirmation for the necessity to consider the population origin, as well as cultural background of tested individuals, while

Thermodynamic correlations for the accident analysis of HTR's

International Nuclear Information System (INIS)

Rehm, W.; Jahn, W.; Finken, R.

1976-12-01

The thermal properties of Helium and for the case of a depressurized primary circuit, various mixtures of primary cooling gas were taken into consideration. The temperature dependence of the correlations for the thermal properties of the graphite components in the core and for the structural materials in the primary circuit are extrapolated about normal operation conditions. Furthermore the correlations for the effective thermal conductivity, the heat transfer and pressure drop are described for pebble bed HTR's. In addition some important heat transfer data of the steam generator are included. With these correlations, for example accident sequences with failure of the afterheat removal systems are discussed for pebble bed HTR's. It is concluded that the transient temperature behaviour demonstrates the inherent safety features of the HTR in extreme accidents. (orig.) [de

Waste heat of HTR power stations for district heating

International Nuclear Information System (INIS)

Bonnenberg, H.; Schlenker, H.V.

1975-01-01

The market situation, the applied techniques, and the transport, for district heating in combination with HTR plants are considered. Analysis of the heat market indicates a high demand for heat at temperatures between 100 and 150 0 C in household and industry. This market for district heating can be supplied by heat generated in HTR plants using two methods: (1) the combined heat and power generation in steam cycle plants by extracting steam from the turbine, and (2) the use of waste heat of a closed gas turbine cycle. The heat generation costs of (2) are negligible. The cost for transportation of heat over the average distance between existing plant sites and consumer regions (25 km) are between 10 and 20% of the total heat price, considering the high heat output of nuclear power stations. Comparing the price of heat gained by use of waste heat in HTR plants with that of conventional methods, considerable advantages are indicated for the combined heat and power generation in HTR plants. (author)

Periodic safety review of the HTR-10 safety analysis

International Nuclear Information System (INIS)

Chen Fubing; Zheng Yanhua; Shi Lei; Li Fu

2015-01-01

Designed by the Institute of Nuclear and New Energy Technology (INET) of Tsinghua University, the 10 MW High Temperature Gas-cooled Reactor-Test Module (HTR-10) is the first modular High Temperature Gas-cooled Reactor (HTGR) in China. According to the nuclear safety regulations of China, the periodic safety review (PSR) of the HTR-10 was initiated by INET after approved by the National Nuclear Safety Administration (NNSA) of China. Safety analysis of the HTR-10 is one of the key safety factors of the PSR. In this paper, the main contents in the review of safety analysis are summarized; meanwhile, the internal evaluation on the review results is presented by INET. (authors)

HTR fuel development for advanced application

International Nuclear Information System (INIS)

Nickel, H.; Balthesen, E.; Graham, L.W.; Hick, H.

1975-01-01

The advantages of the HTR for nuclear steam supply systems are briefly outlined. Due to its great design flexibility a number of different designs have evolved and the main characteristics of existing experimental prototype and power reactor HTR designs are summarized. The present state of coated particle fuel, particularly with regard to performance, is considered. Some implications of producing higher temperatures are discussed. Finally some of the developments in progress such as minimising the temperature drop between fuel and coolant, and of improving fuel performance by better fission product retention, better chemical stability, and the use of alternative coated materials, are discussed. (U.K.)

Turbo-machine deployment of HTR-10 GT

International Nuclear Information System (INIS)

Zhu Shutang; Wang Jie; Zhang Zhengming; Yu Suyuan

2005-01-01

As a testing project of gas turbine modular High Temperature Gas-cooled Reactor (HTGR), HTR-10GT has been studied and developed by Institute of Nuclear and New Energy Technology (INET) of Tsinghua University after the success of HTR-10 with steam turbine cycle. The main purposes of this project are to demonstrate the gas turbine modular HTGR, to optimize the deployment of Power Conversion Unit (PCU) and to verify the techniques of turbo-machine, operating modes and controlling measures. HTR-10GT is concentrated on the PCU design and the turbo-machine deployment. Possible turbo-machine deployments have been investigated and two of them are introduced in this paper. The preliminary design for the turbo-machine of HTR-10GT is single-shaft of vertical layout, arranged by the side of the reactor and the turbo-compressor rotary speed was selected to be 250 s -1 (15000 r/min) by considering the efficiency of turbo-compressor blade systems, the strength conditions and the mass and size characteristics of the turbo-compressor. The rotor system will be supported by electromagnetic bearings (EMBs) to curb the possible pollutions of the primary loop. Of all the components in this design, the high speed turbo-generator seems to be a world-wide technical nut. As an alternative design, a gearbox complex is used to reduce the rotary speed from the turbo-compressor 250 s -1 to 50 s -1 so that the ordinary generator can be used. (authors)

A 350 MW HTR with an annular pebble bed core

International Nuclear Information System (INIS)

Wang Dazhong; Jiang Zhiqiang; Gao Zuying; Xu Yuanhui

1992-12-01

A conceptual design of HTR-module with an annular pebble bed core was proposed. This design can increase the unit power capacity of HTR-Module from 200 MWt to 350 MWt while it can keep the inherent safety characteristics of modular reactor. The preliminary safety analysis results for 350 MW HTR are given. In order to solve the problem of uneven helium outlet temperature distribution a gas flow mixing structure at bottom of core was designed. The experiment results of a gas mixing simulation test rig show that the mixing function can satisfy the design requirements

Genetic variation in HTR4 and lung function: GWAS follow-up in mouse.

Science.gov (United States)

House, John S; Li, Huiling; DeGraff, Laura M; Flake, Gordon; Zeldin, Darryl C; London, Stephanie J

2015-01-01

Human genome-wide association studies (GWASs) have identified numerous associations between single nucleotide polymorphisms (SNPs) and pulmonary function. Proving that there is a causal relationship between GWAS SNPs, many of which are noncoding and without known functional impact, and these traits has been elusive. Furthermore, noncoding GWAS-identified SNPs may exert trans-regulatory effects rather than impact the proximal gene. Noncoding variants in 5-hydroxytryptamine (serotonin) receptor 4 (HTR4) are associated with pulmonary function in human GWASs. To gain insight into whether this association is causal, we tested whether Htr4-null mice have altered pulmonary function. We found that HTR4-deficient mice have 12% higher baseline lung resistance and also increased methacholine-induced airway hyperresponsiveness (AHR) as measured by lung resistance (27%), tissue resistance (48%), and tissue elastance (30%). Furthermore, Htr4-null mice were more sensitive to serotonin-induced AHR. In models of exposure to bacterial lipopolysaccharide, bleomycin, and allergic airway inflammation induced by house dust mites, pulmonary function and cytokine profiles in Htr4-null mice differed little from their wild-type controls. The findings of altered baseline lung function and increased AHR in Htr4-null mice support a causal relationship between genetic variation in HTR4 and pulmonary function identified in human GWAS. © FASEB.

Two Phase Flow Stability in the HTR-10 Steam Generator

Institute of Scientific and Technical Information of China (English)

居怀明; 左开芬; 刘志勇; 徐元辉

2001-01-01

A 10 MW High Temperature Gas Cooled Reactor (HTR-10) designed bythe Institute of Nuclear Energy Technology (INET) is now being constructed. The steam generator (SG) in the HTR-10 is one of the most important components for reactor safety. The thermal-hydraulic performance of the SG was investigated. A full scale HTR-10 Steam Generator Two Tube Engineering Model Test Facility (SGTM-10) was installed and tested at INET. This paper describes the SGTM-10 thermal hydraulic experimental system in detail. The SGTM-10 simulates the actual thermal and structural parameters of the HTR-10. The SGTM-10 includes three separated loops: the primary helium loop, the secondary water loop, and the tertiary cooling water loop. Two parallel tubes are arranged in the test assembly. The main experimental equipment is shown in the paper. Expermental results are given illustrating the effects of the outlet pressures, the heating power, and the inlet subcooling.

Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila

International Nuclear Information System (INIS)

Igaki, Tatsushi; Suzuki, Yasuyuki; Tokushige, Naoko; Aonuma, Hiroka; Takahashi, Ryosuke; Miura, Masayuki

2007-01-01

Despite the essential role of mitochondria in a variety of mammalian cell death processes, the involvement of mitochondrial pathway in Drosophila cell death has remained unclear. To address this, we cloned and characterized DmHtrA2, a Drosophila homolog of a mitochondrial serine protease HtrA2/Omi. We show that DmHtrA2 normally resides in mitochondria and is up-regulated by UV-irradiation. Upon receipt of apoptotic stimuli, DmHtrA2 is translocated to extramitochondrial compartment; however, unlike its mammalian counterpart, the extramitochondrial DmHtrA2 does not diffuse throughout the cytosol but stays near the mitochondria. RNAi-mediated knock-down of DmHtrA2 in larvae or adult flies results in a resistance to stress stimuli. DmHtrA2 specifically cleaves Drosophila inhibitor-of-apoptosis protein 1 (DIAP1), a cellular caspase inhibitor, and induces cell death both in vitro and in vivo as potent as other fly cell death proteins. Our observations suggest that DmHtrA2 promotes cell death through a cleavage of DIAP1 in the vicinity of mitochondria, which may represent a prototype of mitochondrial cell death pathway in evolution

Simulation of Thermal-hydraulic Process in Reactor of HTR-PM

International Nuclear Information System (INIS)

Zhou Kefeng; Zhou Yangping; Sui Zhe; Ma Yuanle

2014-01-01

This paper provides the physical process in the reactor of High Temperature Gas-cooled Reactor Pebble-bed Module (HTR-PM) and introduces the standard operation conditions. The FORTRAN code developed for the thermal hydraulic module of Full-Scale Simulator (FSS) of HTR-PM is used to simulate two typical operation transients including cold startup process and cold shutdown process. And the results were compared to the safety analysis code, namely TINTE. The good agreement indicates that the code is applicable for simulating the thermal-hydraulic process in reactor of HTR-PM. And for long time transient process, the code shows good stability and convergence. (author)

Activity report 2015 Commission Perspectives du Reseau

International Nuclear Information System (INIS)

Ricour, Olivia

2016-01-01

This document contains the activity report for 2015 of the Commission Perspectives du Reseau which has been set up by RTE to be the main body for organising a dialogue with all the actors of the energy sector and civil society about challenges and stakes of the electric power system on the medium and on the long term. It describes how this body aims at sharing knowledge and expertise of all stakeholders (publications, European platform for data transparency), at being a place for debating and enriching the understanding of tomorrow's important stakes for the power system (discussion of the issue of greenhouse gas emissions with an analysis of the impact of the CO 2 price signal on emissions by the European electricity system and results of the e-Highway 2050 European project). The road-map of the Commission works for 2016 is provided, as well as a list of members

Engineering and licensing progress of the HTR-Module

Energy Technology Data Exchange (ETDEWEB)

Weisbrodt, I A

1988-07-01

This report deals not only with the latest status of Siemens/Interatom's HTR-Module but also reflects the latest engineering and licensing progress of the HTR-Module against the background of the specified design requirements and of the discussions on passively safe reactors. Therefore, I intend to report also about two examples of the accident analysis - one design basis accident, i.e. the leak-before-break of the reactor pressure vessel and one beyond design accident, i. e. massive water ingress.

Engineering and licensing progress of the HTR-Module

International Nuclear Information System (INIS)

Weisbrodt, I.A.

1988-01-01

This report deals not only with the latest status of Siemens/Interatom's HTR-Module but also reflects the latest engineering and licensing progress of the HTR-Module against the background of the specified design requirements and of the discussions on passively safe reactors. Therefore, I intend to report also about two examples of the accident analysis - one design basis accident, i.e. the leak-before-break of the reactor pressure vessel and one beyond design accident, i. e. massive water ingress

Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood.

Science.gov (United States)

Li, Ying; Salamonsen, Lois A; Hyett, Jonathan; Costa, Fabricio da Silva; Nie, Guiying

2017-07-04

High temperature requirement factor A3 (HtrA3), a member of the HtrA protease family, is highly expressed in the developing placenta, including the maternal decidual cells in both mice and humans. In this study we deleted the HtrA3 gene in the mouse and crossed females carrying zero, one, or two HtrA3-expressing alleles with HtrA3 +/- males to investigate the role of maternal vs fetal HtrA3 in placentation. Although HtrA3 -/- mice were phenotypically normal and fertile, HtrA3 deletion in the mother resulted in intra-uterine growth restriction (IUGR). Disorganization of labyrinthine fetal capillaries was the major placental defect when HtrA3 was absent. The IUGR caused by maternal HtrA3 deletion, albeit being mild, significantly altered offspring growth trajectory long after birth. By 8 months of age, mice born to HtrA3-deficient mothers, independent of their own genotype, were significantly heavier and contained a larger mass of white fat. We further demonstrated that in women serum levels of HtrA3 during early pregnancy were significantly lower in IUGR pregnancies, establishing an association between lower HtrA3 levels and placental insufficiency in the human. This study thus revealed the importance of maternal HtrA3 in optimizing placental development and its long-term impact on the offspring well beyond in utero growth.

HTR-E project. High-temperature components and systems

International Nuclear Information System (INIS)

Breuil, E.; Exner, R.

2002-01-01

The HTR-E European project (four years project) is proposed for the 5th Framework Programme and concerns the technical developments needed for the innovative components of a modern HTR with a direct cycle. These components have been selected with reference to the present projects (GT-MHR, PBMR): (1) the helium turbine, the recuperator heat exchanger, the electro-magnetic bearings and the helium rotating seal; (2) the tribology. Sliding innovative components in helium environment are particularly concerned. (3) the helium purification system. Recommendations on impurities contents have to be provided in accordance with the materials proposed for the innovative components. The main outcomes expected from the HTR-E project are the design recommendations and identification of further R and D needs for these components. This will be based: (1) on experience feedback from European past helium test loops and reactors; (2) on design studies, thermal-hydraulic and structural analyses; (3) and on experimental tests

The HTR 500 concept based on pratical THTR and AVR experience

International Nuclear Information System (INIS)

Wachholz, W.; Weicht, U.

1988-01-01

This paper discusses progress during the past ten years in the development of a specific HTR safety concept. This has been mainly characterized by the abandonment of the LWR specific safety principles and making use of the safety characteristics typical of the high-temperature reactor (HTR). In the design, construction and operation of high-temperature reactors - especially AVR (15 MWe plant in Juelich, FRG) and THTR (300 MWe plant in Hamm-Uentrop, FRG) - experience has been gained in the field of accident topology and plant risk of HTRs in recent years. This experience, based on detailed accident analyses performed by manufacturers and experts, is relevant for the entire HTR line independent of specific projects. The authors focus on the HTR 500, the first commercial high temperature reactor with a pebble bed core. Its design principles and the design of its systems are based on the earlier AVR and THTR projects

Experiment study on thermal mixing performance of HTR-PM reactor outlet

Energy Technology Data Exchange (ETDEWEB)

Zhou, Yangping, E-mail: zhouyp@mail.tsinghua.edu.cn [Institute of Nuclear and New Energy Technology, Collaborative Innovation Center of Advanced Nuclear Energy Technology, the Key Laboratory of Advanced Reactor Engineering and Safety, Ministry of Education, Tsinghua University, Beijing 100084 (China); Hao, Pengfei [School of Aerospace, Tsinghua University, Beijing 100084 (China); Li, Fu; Shi, Lei [Institute of Nuclear and New Energy Technology, Collaborative Innovation Center of Advanced Nuclear Energy Technology, the Key Laboratory of Advanced Reactor Engineering and Safety, Ministry of Education, Tsinghua University, Beijing 100084 (China); He, Feng [School of Aerospace, Tsinghua University, Beijing 100084 (China); Dong, Yujie; Zhang, Zuoyi [Institute of Nuclear and New Energy Technology, Collaborative Innovation Center of Advanced Nuclear Energy Technology, the Key Laboratory of Advanced Reactor Engineering and Safety, Ministry of Education, Tsinghua University, Beijing 100084 (China)

2016-09-15

A model experiment is proposed to investigate the thermal mixing performance of HTR-PM reactor outlet. The design of the test facility is introduced, which is set at a scale of 1:2.5 comparing with the design of thermal mixing structure at HTR-PM reactor outlet. The test facility using air as its flow media includes inlet pipe system, electric heaters, main mixing structure, hot gas duct, exhaust pipe system and I&C system. Experiments are conducted on the test facility and the values of thermal-fluid parameters are collected and analyzed, which include the temperature, pressure and velocity of the flow as well as the temperature of the tube wall. The analysis results show the mixing efficiency of the test facility is higher than that required by the steam generator of HTR-PM, which indicates that the thermal mixing structure of HTR-PM fulfills its design requirement.

DNA Methylation Analysis of HTR2A Regulatory Region in Leukocytes of Autistic Subjects.

Science.gov (United States)

Hranilovic, Dubravka; Blazevic, Sofia; Stefulj, Jasminka; Zill, Peter

2016-02-01

Disturbed brain and peripheral serotonin homeostasis is often found in subjects with autism spectrum disorder (ASD). The role of the serotonin receptor 2A (HTR2A) in the regulation of central and peripheral serotonin homeostasis, as well as its altered expression in autistic subjects, have implicated the HTR2A gene as a major candidate for the serotonin disturbance seen in autism. Several studies, yielding so far inconclusive results, have attempted to associate autism with a functional SNP -1438 G/A (rs6311) in the HTR2A promoter region, while possible contribution of epigenetic mechanisms, such as DNA methylation, to HTR2A dysregulation in autism has not yet been investigated. In this study, we compared the mean DNA methylation within the regulatory region of the HTR2A gene between autistic and control subjects. DNA methylation was analysed in peripheral blood leukocytes using bisulfite conversion and sequencing of the HTR2A region containing rs6311 polymorphism. Autistic subjects of rs6311 AG genotype displayed higher mean methylation levels within the analysed region than the corresponding controls (P epigenetic mechanisms might contribute to HTR2A dysregulation observed in individuals with ASD. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.

Design on Hygrometry System of Primary Coolant Circuit of HTR-PM

International Nuclear Information System (INIS)

Sun Yanfei; Zhong Shuoping; Huang Xiaojin

2014-01-01

Helium is the primary coolant in HTR-PM. If vapor get into the helium in primary coolant circuit because of some special reasons, such as the broken of steam-generator tube, chemical reaction will take effect between the graphite in reactor core and vapor in primary coolant circuit, and the safety of the reactor operation will be influenced. So the humidity of the helium in primary coolant circuit is one key parameter of HTR-PM to be monitored in-line. Once the humidity is too high, trigger signal of turning off the reactor must be issued. The hygrometry system of HTR-PM is consisting of filter, cooler, hygrometry sensor, flow meter, and some valves and tube. Helium with temperature of 250℃ is lead into the hygrometry system from the outlet of the main helium blower. After measuring, the helium is re-injected back to the primary circuit. No helium loses in this processing, and no other pump is needed. Key factors and calculations in design on hygrometry system of HTR-PM are described. A sample instrument has been made. Results of experiments proves that this hygrometry system is suitable for monitoring the humidity of the primary coolant of HTR-PM. (author)

HTR core physics and transient analyses by the Panthermix code system

International Nuclear Information System (INIS)

Haas, J.B.M. de; Kuijper, J.C.; Oppe, J.

2005-01-01

At NRG Petten, core physics analyses on High Temperature gas-cooled Reactors (HTRs) are mainly performed by means of the PANTHERMIX code system. Since some years NRG is developing the HTR reactor physics code system WIMS/PANTHERMIX, based on the lattice code WIMS (Serco Assurance, UK), the 3-dimensional steady-state and transient core physics code PANTHER (British Energy, UK) and the 2-dimensional R-Z HTR thermal hydraulics code THERMIX-DIREKT (Research Centre FZJ Juelich, Germany). By means of the WIMS code nuclear data are being generated to suit the PANTHER code's neutronics. At NRG the PANTHER code has been interfaced with THERMIX-DIREKT to form PANTHERMIX, to enable core-follow/fuel management and transient analyses in a consistent manner on pebble bed type HTR systems. Also provisions have been made to simulate the flow of pebbles through the core of a pebble bed HTR, according to a given (R-Z) flow pattern. As examples of the versatility of the PANTHERMIX code system, calculations are presented on the PBMR, the South African pebble bed reactor design, to show the transient capabilities, and on a plutonium burning MEDUL-reactor, to demonstrate the core-follow/fuel management capabilities. For the investigated cases a good agreement is observed with the results of other HTR core physics codes

Potentialities of high temperature reactors (HTR)

International Nuclear Information System (INIS)

Hittner, D.

2001-01-01

This articles reviews the assets of high temperature reactors concerning the amount of radioactive wastes produced. 2 factors favors HTR-type reactors: high thermal efficiency and high burn-ups. The high thermal efficiency is due to the high temperature of the coolant, in the case of the GT-MHR project (a cooperation between General Atomic, Minatom, Framatome, and Fuji Electric) designed to burn Russian military plutonium, the expected yield will be 47% with an outlet helium temperature of 850 Celsius degrees. The high temperature of the coolant favors a lot of uses of the heat generated by the reactor: urban heating, chemical processes, or desalination of sea water.The use of a HTR-type reactor in a co-generating way can value up to 90% of the energy produced. The high burn-up is due to the technology of HTR-type fuel that is based on encapsulation of fuel balls with heat-resisting materials. The nuclear fuel of Fort-Saint-Vrain unit (Usa) has reached values of burn-ups from 100.000 to 120.000 MWj/t. It is shown that the quantity of unloaded spent fuel can be divided by 4 for the same amount of electricity produced, in the case of the GT-MHR project in comparison with a light water reactor. (A.C.)

Variations de la température de l'eau des étangs en période froide à ...

African Journals Online (AJOL)

SARAH

30 juin 2015 ... Conclusion et application : La mise en évidence de la courbe de variation de température en période froide à Lubumbashi est cruciale pour la mise en place des systèmes de .... niloticus) et le poisson-chat africain (Clarias ngamensis et Clarias gariepinus). Les étangs dont la profondeur varie entre 120 et ...

Reseau Environnement's brief on the project regarding atmospheric regulations : submitted to the Minister of Sustainable Development, Environment and Parks

International Nuclear Information System (INIS)

2006-01-01

Reseau Environnement is a Montreal-based organization that promotes the protection of ecosystems and human health. Their mandate is to extend the existing standards for reducing pollutants and to tap the full potential of Quebec expertise in addressing pollution sources. Reseau Environnement recently appealed to the Quebec Minister of Sustainable Development, Environment and Parks to develop clear, flexible and modern regulations for Quebec, similar to those found in Europe and the United States, to efficiently control atmospheric emissions in an effort to counteract the negative effects they impart on ecosystems and human health. Among the requests was the revision of certain pollution regulation clauses to regulate odor emissions; identify preferred measuring methods for pollutants; apply ambient air quality standards to existing installations; apply standards for particulates; impose requirements for the frequency of pollution sampling and make changes to some components of Montreal's Regulation 90 regarding air pollution from industrial activities. 13 refs

Fuel management of HTR-10

International Nuclear Information System (INIS)

Wu Zongxin; Jing Xingqing

2001-01-01

The 10 MW high temperature cooled reactor (HTR-10) built in Tsinghua University is a pebble bed type of HTGR. The continuous recharge and multiple-pass of spherical fuel elements are used for fuel management. The initiative stage of core is composed of the mix of spherical fuel elements and graphite elements. The equilibrium stage of core is composed of identical spherical fuel elements. The fuel management during the transition from the initiative stage to the equilibrium stage is a key issue for HTR-10 physical design. A fuel management strategy is proposed based on self-adjustment of core reactivity. The neutron physical code is used to simulate the process of fuel management. The results show that the graphite elements, the recharging fuel elements below the burn-up allowance, and the discharging fuel elements over the burn-up allowance could be identified by burn-up measurement. The maximum of burn-up fuel elements could be controlled below the burn-up limit

Gas reactor international cooperative program. HTR-synfuel application assessment

Energy Technology Data Exchange (ETDEWEB)

1979-09-01

This study assesses the technical, environmental and economic factors affecting the application of the High Temperature Gas-Cooled Thermal Reactor (HTR) to: synthetic fuel production; and displacement of fossil fuels in other industrial and chemical processes. Synthetic fuel application considered include coal gasification, direct coal liquefaction, oil shale processing, and the upgrading of syncrude to motor fuel. A wide range of other industrial heat applications was also considered, with emphasis on the use of the closed-loop thermochemical energy pipeline to supply heat to dispersed industrial users. In this application syngas (H/sub 2/ +CO/sub 2/) is produced at the central station HTR by steam reforming and the gas is piped to individual methanators where typically 1000/sup 0/F steam is generated at the industrial user sites. The products of methanation (CH/sub 4/ + H/sub 2/O) are piped back to the reformer at the central station HTR.

Gas reactor international cooperative program. HTR-synfuel application assessment

International Nuclear Information System (INIS)

1979-09-01

This study assesses the technical, environmental and economic factors affecting the application of the High Temperature Gas-Cooled Thermal Reactor (HTR) to: synthetic fuel production; and displacement of fossil fuels in other industrial and chemical processes. Synthetic fuel application considered include coal gasification, direct coal liquefaction, oil shale processing, and the upgrading of syncrude to motor fuel. A wide range of other industrial heat applications was also considered, with emphasis on the use of the closed-loop thermochemical energy pipeline to supply heat to dispersed industrial users. In this application syngas (H 2 +CO 2 ) is produced at the central station HTR by steam reforming and the gas is piped to individual methanators where typically 1000 0 F steam is generated at the industrial user sites. The products of methanation (CH 4 + H 2 O) are piped back to the reformer at the central station HTR

HTR core physics and transient analyses by the Panthermix code system

Energy Technology Data Exchange (ETDEWEB)

Haas, J.B.M. de; Kuijper, J.C.; Oppe, J. [NRG - Fuels, Actinides and Isotopes group, Petten (Netherlands)

2005-07-01

At NRG Petten, core physics analyses on High Temperature gas-cooled Reactors (HTRs) are mainly performed by means of the PANTHERMIX code system. Since some years NRG is developing the HTR reactor physics code system WIMS/PANTHERMIX, based on the lattice code WIMS (Serco Assurance, UK), the 3-dimensional steady-state and transient core physics code PANTHER (British Energy, UK) and the 2-dimensional R-Z HTR thermal hydraulics code THERMIX-DIREKT (Research Centre FZJ Juelich, Germany). By means of the WIMS code nuclear data are being generated to suit the PANTHER code's neutronics. At NRG the PANTHER code has been interfaced with THERMIX-DIREKT to form PANTHERMIX, to enable core-follow/fuel management and transient analyses in a consistent manner on pebble bed type HTR systems. Also provisions have been made to simulate the flow of pebbles through the core of a pebble bed HTR, according to a given (R-Z) flow pattern. As examples of the versatility of the PANTHERMIX code system, calculations are presented on the PBMR, the South African pebble bed reactor design, to show the transient capabilities, and on a plutonium burning MEDUL-reactor, to demonstrate the core-follow/fuel management capabilities. For the investigated cases a good agreement is observed with the results of other HTR core physics codes.

Market potential of heat utilization of modular HTR in Japan

International Nuclear Information System (INIS)

Ide, Akira; Tasaka, Kanji.

1993-01-01

HTR is considered to be the most suitable reactor type to use in the field other than power generation. So it is useful to know market potential of this type of reactor in Japan to justify its development. This potential was estimated to be about 400 200MWt modular HTR reactors. This number will be double if the market of hydrogen is developed. (J.P.N.)

Different contributions of HtrA protease and chaperone activities to Campylobacter jejuni stress tolerance and physiology

DEFF Research Database (Denmark)

Bæk, Kristoffer Torbjørn; Vegge, Christina Skovgaard; Skórko-Glonek, Joanna

2011-01-01

activity is sufficient for growth at high temperature or oxidative stress, whereas the HtrA protease activity is only essential at conditions close to the growth limit for C. jejuni. However, the protease activity was required to prevent induction of the cytoplasmic heat-shock response even at optimal......The microaerophilic bacterium Campylobacter jejuni is the most common cause of bacterial food-borne infections in the developed world. Tolerance to environmental stress relies on proteases and chaperones in the cell envelope such as HtrA and SurA. HtrA displays both chaperone and protease activity......, but little is known about how each of these activities contributes to stress tolerance in bacteria. In vitro experiments showed temperature dependent protease and chaperone activities of C. jejuni HtrA. A C. jejuni mutant lacking only the protease activity of HtrA was used to show that the HtrA chaperone...

An HTR cogeneration system for industrial application

International Nuclear Information System (INIS)

Haverkate, B.R.W.; Van Heek, A.I.; Kikstra, J.F.

1999-01-01

Because of its favourable characteristics of safety and simplicity the high-temperature reactor (HTR) could become a competitive heat source for a cogeneration unit. The Netherlands is a world leading country in the field of cogeneration. As nuclear energy remains an option for the medium and long term in this country, systems for nuclear cogeneration should be explored and developed. Hence, ECN Nuclear Research is developing a conceptual design of an HTR for Combined generation of Heat and Power (CHP) for the industry in and outside the Netherlands. The design of this small CHP-unit for industrial applications is mainly based on a pre-feasibility study in 1996, performed by a joint working group of five Dutch organisations, in which technical feasibility was shown. The concept that was subject of that study, INCOGEN, used a 40 MW thermal pebble bed HTR and produced a maximum amount of electricity plus low temperature heat. The system has been improved to produce industrial quality heat, and has been renamed ACACIA. The output of this installation is 14 MW electricity and 17 tonnes of steam per hour, with a pressure of 10 bar and a temperature of 220C. The economic characteristics of this installation turned out to be much more favourable using modern cost data. 15 refs

Design and application of the HTR-100 industrial nuclear power plant

International Nuclear Information System (INIS)

Brandes, S.; Kohl, W.

1988-01-01

The small HTR-100 high temperature reactor combines the reactor concept of the AVR reactor, which has been proven for 20 years, with the latest component technology of the THTR power plant which has been in operation since 1985. The nuclear heat supply system is conceived so as to be applicable for the generation of electric power, district heat and process steam according to the customer's demand. The HTR-100 reactor has a thermal power of 258 MW and offers steam parameters of 190 bar/530 0 C. To cover a higher power demand HTR-100 reactors can be combined forming a larger power plant. Economic analyses have shown competitiveness with fossil power plants. (orig.)

The Research Status for Decommissioning and Radioactive Waste Minimization of HTR-PM

International Nuclear Information System (INIS)

Li Wenqian; Li Hong; Cao Jianzhu; Tong Jiejuan

2014-01-01

Decommissioning of the high-temperature gas-cooled reactor-pebble bed module (HTR-PM) as a part of the nuclear power plant, is very important during the early design stage of the construction, and it is under study and research currently. This article gives a thorough description of the current decommissioning study status of HTR-PM. Since HTR-PM has its features such as adopting a large amount of graphite, the waste inventory and characterization will be quite different from other type of reactors, new researches should be carried out and good lessons of practices and experiences should be learned from international other reactors, especially the AVR. Based on the new international regulations and Chinese laws, a comprehensive decommissioning program should be proposed to guarantee the HTR-PM will succeed in every stage of the decommissioning, such as defueling, decontamination, dismantling, demolition, waste classification and disposal, etc. In the meantime, the minimization of the radioactive waste should be taken into account during the whole process - before construction, during operation and after shut down. In this article, the decommissioning strategy and program conception of HTR-PM will be introduced, the radiation protection consideration during the decommissioning activities will be discussed, and the research on the activation problem of the decommissioning graphite will be introduced. (author)

Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA

Science.gov (United States)

Schmidt, Thomas P.; Perna, Anna M.; Fugmann, Tim; Böhm, Manja; Jan Hiss; Haller, Sarah; Götz, Camilla; Tegtmeyer, Nicole; Hoy, Benjamin; Rau, Tilman T.; Neri, Dario; Backert, Steffen; Schneider, Gisbert; Wessler, Silja

2016-03-01

The cell adhesion protein and tumour suppressor E-cadherin exhibits important functions in the prevention of gastric cancer. As a class-I carcinogen, Helicobacter pylori (H. pylori) has developed a unique strategy to interfere with E-cadherin functions. In previous studies, we have demonstrated that H. pylori secretes the protease high temperature requirement A (HtrA) which cleaves off the E-cadherin ectodomain (NTF) on epithelial cells. This opens cell-to-cell junctions, allowing bacterial transmigration across the polarised epithelium. Here, we investigated the molecular mechanism of the HtrA-E-cadherin interaction and identified E-cadherin cleavage sites for HtrA. Mass-spectrometry-based proteomics and Edman degradation revealed three signature motifs containing the [VITA]-[VITA]-x-x-D-[DN] sequence pattern, which were preferentially cleaved by HtrA. Based on these sites, we developed a substrate-derived peptide inhibitor that selectively bound and inhibited HtrA, thereby blocking transmigration of H. pylori. The discovery of HtrA-targeted signature sites might further explain why we detected a stable 90 kDa NTF fragment during H. pylori infection, but also additional E-cadherin fragments ranging from 105 kDa to 48 kDa in in vitro cleavage experiments. In conclusion, HtrA targets E-cadherin signature sites that are accessible in in vitro reactions, but might be partially masked on epithelial cells through functional homophilic E-cadherin interactions.

Increased expression of Apo-J and Omi/HtrA2 after Intracerebral Hemorrage in rats.

Science.gov (United States)

Li, Feng; Yang, Jing; Guo, Xiaoyan; Zheng, Xiaomei; Lv, Zhiyu; Shi, Chang Qing; Li, Xiaogang

2018-03-23

To investigate the changes of Apo-J and Omi/HtrA2 protein expression in rats with intracerebral hemorrage. 150 SD adult rats were randomly divided into 3 groups: (1) Normal Control (NC) group, (2) Sham group, (3) Intracerebral Hemorrage (ICH) group. The data were collected at 6h, 12h, 1d, 2d, 3d, 5d and 7d. Apoptosis was measured by Tunel staining. The distributions of the Apo-J and Omi/HtrA2 proteins were determined by immunohistochemical staining. The levels of Apo-J mRNA and Omi/HtrA2 mRNA expressions were examined by RT-PCR. Apoptosis in ICH group was higher than Sham and NC groups (p＜0.05). Both the Apo-J and Omi/HtrA2 expression levels were increased in the peripheral region of hemorrhage, with a peak at 3d. The Apo-J mRNA level positively correlated with HtrA2 mRNA level in ICH group (r=0.883, p＜0.001). The expressions of Apo-J and Omi/HtrA2 paralelly increased in peripheral region of rat cerebral hemorrhage. Local high expressed Apo-J in the peripheral regions might play a neuroprotective role by inhibiting apoptosis via Omi/HtrA2 pathway after hemorrhage. Copyright © 2018. Published by Elsevier Inc.

Gas cooled HTR

International Nuclear Information System (INIS)

Schweiger, F.

1985-01-01

In the He-cooled, graphite-moderated HTR with spherical fuel elements, the steam generator is fixed outside the pressure vessel. The heat exchangers are above the reactor level. The hot gases stream from the reactor bottom over the heat exchanger, through an annular space around the heat exchanger and through feed lines in the side reflector of the reactor back to its top part. This way, in case of shutdown there is a supplementary natural draught that helps the inner natural circulation (chimney draught effect). (orig./PW)

Solution of multiple circuits of steam cycle HTR system

International Nuclear Information System (INIS)

Li, Fu; Wang, Dengying; Hao, Chen; Zheng, Yanhua

2014-01-01

In order to analyze the dynamic operation performance and safety characteristics of the steam cycle high temperature gas cooled reactor (HTR) systems, it is necessary to find the solution of the whole HTR systems with all coupled circuits, including the primary circuit, the secondary circuit, and the residual heat removal system (RHRS). Considering that those circuits have their own individual fluidity and characteristics, some existing code packages for independent circuits themselves have been developed, for example THEMRIX and TINTE code for the primary circuit of the pebble bed reactor, BLAST for once through steam generator. To solve the coupled steam cycle HTR systems, a feasible way is to develop coupling method to integrate these independent code packages. This paper presents several coupling methods, e.g. the equivalent component method between the primary circuit and steam generator which reflect the close coupling relationship, the overlapping domain decomposition method between the primary circuit and the passive RHRS which reflects the loose coupling relationship. Through this way, the whole steam cycle HTR system with multiple circuits can be easily and efficiently solved by integration of several existing code packages. Based on this methodology, a code package TINTE–BLAST–RHRS was developed. Using this code package, some operation performance of HTR–PM was analyzed, such as the start-up process of the plant, and the depressurized loss of forced cooling accident when different number of residual heat removal trains is operated

Preliminary ripple effect analysis for HTR 350MWt 4 modules construction

Energy Technology Data Exchange (ETDEWEB)

Lee, T. H.; Lee, K. Y.; Shin, Y. J. [KAERI, Daejeon (Korea, Republic of)

2016-05-15

We propose quantitative analysis techniques for ripple effects such as the production inducement effect and employment inducement effect for HTR 350MWt x 4 module construction and operation ripple effect based on NOAK. It is known that APR1400 reactors export ripple effect is about 8,500 billion KRW. As a result, HTR construction has more effective effect than that of APR1400.

Influence of Polymorphisms in the HTR3A and HTR3B Genes on Experimental Pain and the Effect of the 5-HT3 Antagonist Granisetron.

Science.gov (United States)

Louca Jounger, Sofia; Christidis, Nikolaos; Hedenberg-Magnusson, Britt; List, Thomas; Svensson, Peter; Schalling, Martin; Ernberg, Malin

2016-01-01

The aim of this study was to investigate experimentally if 5-HT3 single nucleotide polymorphisms (SNP) contribute to pain perception and efficacy of the 5-HT3-antagonist granisetron and sex differences. Sixty healthy participants were genotyped regarding HTR3A (rs1062613) and HTR3B (rs1176744). First, pain was induced by bilateral hypertonic saline injections (HS, 5.5%, 0.2 mL) into the masseter muscles. Thirty min later the masseter muscle on one side was pretreated with 0.5 mL granisetron (1 mg/mL) and on the other side with 0.5 mL placebo (isotonic saline) followed by another HS injection (0.2 mL). Pain intensity, pain duration, pain area and pressure pain thresholds (PPTs) were assessed after each injection. HS evoked moderate pain, with higher intensity in the women (P = 0.023), but had no effect on PPTs. None of the SNPs influenced any pain variable in general, but compared to men, the pain area was larger in women carrying the C/C (HTR3A) (P = 0.015) and pain intensity higher in women with the A/C alleles (HTR3B) (P = 0.019). Pre-treatment with granisetron reduced pain intensity, duration and area to a lesser degree in women (P granisetron. Women carrying the C/T & T/T (HTR3A) genotype had less reduction of pain intensity (P = 0.041) and area (P = 0.005), and women with the C/C genotype (HTR3B) had less reduction of pain intensity (P = 0.030), duration (P = 0.030) and area compared to men (P = 0.017). In conclusion, SNPs did not influence experimental muscle pain or the effect of granisetron on pain variables in general, but there were some sex differences in pain variables that seem to be influenced by genotypes. However, due to the small sample size further research is needed before any firm conclusions can be drawn.

Influence of Polymorphisms in the HTR3A and HTR3B Genes on Experimental Pain and the Effect of the 5-HT3 Antagonist Granisetron.

Directory of Open Access Journals (Sweden)

Sofia Louca Jounger

Full Text Available The aim of this study was to investigate experimentally if 5-HT3 single nucleotide polymorphisms (SNP contribute to pain perception and efficacy of the 5-HT3-antagonist granisetron and sex differences. Sixty healthy participants were genotyped regarding HTR3A (rs1062613 and HTR3B (rs1176744. First, pain was induced by bilateral hypertonic saline injections (HS, 5.5%, 0.2 mL into the masseter muscles. Thirty min later the masseter muscle on one side was pretreated with 0.5 mL granisetron (1 mg/mL and on the other side with 0.5 mL placebo (isotonic saline followed by another HS injection (0.2 mL. Pain intensity, pain duration, pain area and pressure pain thresholds (PPTs were assessed after each injection. HS evoked moderate pain, with higher intensity in the women (P = 0.023, but had no effect on PPTs. None of the SNPs influenced any pain variable in general, but compared to men, the pain area was larger in women carrying the C/C (HTR3A (P = 0.015 and pain intensity higher in women with the A/C alleles (HTR3B (P = 0.019. Pre-treatment with granisetron reduced pain intensity, duration and area to a lesser degree in women (P < 0.05, but the SNPs did not in general influence the efficacy of granisetron. Women carrying the C/T & T/T (HTR3A genotype had less reduction of pain intensity (P = 0.041 and area (P = 0.005, and women with the C/C genotype (HTR3B had less reduction of pain intensity (P = 0.030, duration (P = 0.030 and area compared to men (P = 0.017. In conclusion, SNPs did not influence experimental muscle pain or the effect of granisetron on pain variables in general, but there were some sex differences in pain variables that seem to be influenced by genotypes. However, due to the small sample size further research is needed before any firm conclusions can be drawn.

Current status and technical description of Chinese 2 x 250 MWth HTR-PM demonstration plant

International Nuclear Information System (INIS)

Zhang Zuoyi; Wu Zongxin; Wang Dazhong; Xu Yuanhui; Sun Yuliang; Li Fu; Dong Yujie

2009-01-01

After the nuclear accidents of Three Mile Island and Chernobyl the world nuclear community made great efforts to increase research on nuclear reactors and to develop advanced nuclear power plants with much improved safety features. Following the successful construction and a most gratifying operation of the 10 MW th high-temperature gas-cooled test reactor (HTR-10), the Institute of Nuclear and New Energy Technology (INET) of Tsinghua University has developed and designed an HTR demonstration plant, called the HTR-PM (high-temperature-reactor pebble-bed module). The design, having jointly been carried out with industry partners from China and in collaboration of experts worldwide, closely follows the design principles of the HTR-10. Due to intensive engineering and R and D efforts since 2001, the basic design of the HTR-PM has been finished while all main technical features have been fixed. A Preliminary Safety Analysis Report (PSAR) has been compiled. The HTR-PM plant will consist of two nuclear steam supply system (NSSS), so called modules, each one comprising of a single zone 250 MW th pebble-bed modular reactor and a steam generator. The two NSSS modules feed one steam turbine and generate an electric power of 210 MW. A pilot fuel production line will be built to fabricate 300,000 pebble fuel elements per year. This line is closely based on the technology of the HTR-10 fuel production line. The main goals of the project are two-fold. Firstly, the economic competitiveness of commercial HTR-PM plants shall be demonstrated. Secondly, it shall be shown that HTR-PM plants do not need accident management procedures and will not require any need for offsite emergency measures. According to the current schedule of the project the completion date of the demonstration plant will be around 2013. The reactor site has been evaluated and approved; the procurement of long-lead components has already been started. After the successful operation of the demonstration plant

Relevant safety issues in designing the HTR-10 reactor

International Nuclear Information System (INIS)

Sun Yuliang; Xu Yuanghui

2001-01-01

The HTR-10 is a 10 MWth pebble bed high temperature gas cooled reactor being constructed as a research facility at the Institute of Nuclear Energy Technology. This paper discusses design issues of the HTR-10 which are related to safety. It addresses the safety criteria used in the development and assessment of the design, the safety important systems, and the safety classification of components. It also summarises the results of safety analysis, including the approach used for the radioactive source term, as well as the approach to containment design. (author)

Fabrication technology of spherical fuel element for HTR-10

International Nuclear Information System (INIS)

He Jun; Zou Yanwen; Liang Tongxiang; Qiu Xueliang

2002-01-01

R and D on the fabrication technology of the spherical fuel elements for the 10 MW HTR Test Module (HTR-10) began from 1986. Cold quasi-isostatic molding with a silicon rubber die is used for manufacturing the spherical fuel elements.The fabrication technology and the graphite matrix materials were investigated and optimized. Twenty five batches of fuel elements, about 11000 of the fuel elements, have been produced. The cold properties of the graphite matrix materials satisfied the design specifications. The mean free uranium fraction of 25 batches was 5 x 10 -5

Overview of Japanese seismic research program for HTR

International Nuclear Information System (INIS)

Ikushima, T.

1978-01-01

In order to obtain the license for construction and operation of HTR developed in and/or introduced into Japan, it is necessary to insure the integrity of reactor structures and the capability of reactor shutdown and the maintenance of safety shutdown for the seismic design condition. Because Japan is located in relatively high seismicity zone, even when an excessive earthquake would occur, the public and plant personnel should be protected from radiation hazard. The report describes the following: (1) present status of development and construction plan of HTR, (2) guideline of aseismic design, (3) need of aseismic research, (4) present status of research and development, and (5) future plans

Objectives for an HTR R and D physics programme

Energy Technology Data Exchange (ETDEWEB)

Johnstone, I; Scott, J A

1973-10-15

The paper reviews important objectives for an HTR R and D programme and the importance of particular characteristics for safety and reactor performance is discussed. Uncertainties in the physics characteristics influence reactor design through the inclusion of design margins and contingency allowances and may even eliminate certain design variants. The paper discusses quantitatively the relationship between some important uncertainties and reactor design and operating costs and derives targets for the precision with which it should be possible to compute the corresponding physics characteristics. To extrapolate to power reactor conditions, the need for a comprehensive computational scheme validated by an adequate experimental programme is emphasised. The reduction in uncertainty as the theoretical and experimental reactor physics development proceeds in order to meet the desired target uncertainty is illustrated with respect to the UK's programme in support of the low enriched HTR concept. The current situation for this concept is discussed and compared briefly with that for the Th cycle HTR for which somewhat less zero energy experimental data are available. (auth)

La chaîne de froid en amont de la filière pêche artisanale au Sénégal: état des lieux et mise à niveau

OpenAIRE

Sarr, S. L.

2009-01-01

La présente étude porte sur l’état des lieux et la mise à niveau de la chaîne de froid en Amont de la filière pêche artisanale au Sénégal, notamment dans les régions de Thiès et de Dakar. L’objectif de cette étude est d’une part, de faire l’état des lieux des infrastructures de froid dans les pirogues, les quais pilotes de débarquement, les véhicules de transport et le Marché Central au Poisson de Dakar, d’autre part de formuler un programme de mise à niveau visant à solutionner les insuffisa...

Le projet SCORE (Superior cold recycling) : Recyclage à froid des matériaux bitumineux - Etudes de formulation

OpenAIRE

ECKMANN, B; DELFOSSE, F; PENA, JL; WALTER, J; LANCASTER, IM; BAENA, JM; ODIE, L; NAUDAT, C; BROSSEAUD, Y; BEGHIN, A; PLACIN, F

2006-01-01

Afin de promouvoir les technologies de construction favorables à l'environnement (Environmentally Friendly Construction Technologies EFCT) et pour son 5è programme cadre de recherche et développement (PCRD), la Commission européenne a décidé de financer un projet de recherche sur le retraitement en place à froid, intitulé SCORE "Superior Cold Recycling based on benefits of bituminous microemulsions and foamed bitumen. A EFCT system for the rehabilitation and the maintenance of roads" et visan...

Symbiosis of near breeder HTR's with hybrid fusion reactors

International Nuclear Information System (INIS)

Seifritz, W.

1978-07-01

In this contribution to INFCE a symbiotic fusion/fission reactor system, consisting of a hybrid beam-driven micro-explosion fusion reactor (HMER) and associated high-temperature gas-cooled reactors (HTR) with a coupled fuel cycle, is proposed. This system is similar to the well known Fast Breeder/Near Breeder HTR symbiosis except that the fast fission breeder - running on the U/Pu-cycle in the core and the axial blankets and breeding the surplus fissile material as U-233 in its radial thorium metal or thorium oxide blankets - is replaced by a hybrid micro-explosion DT fusion reactor

HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memory.

Science.gov (United States)

Drago, Antonio; Alboni, Silvia; Brunello, Nicoletta; Nicoletta, Brunello; De Ronchi, Diana; Serretti, Alessandro

2010-01-01

Serotonin receptor 1B (HTR1B) is involved in the regulation of the serotonin system, playing different roles in specific areas of the brain. We review the characteristics of the gene coding for HTR1B, its product and the functional role of HTR1B in the neural networks involved in motivation and memory; the central role played by HTR1B in these functions is thoroughly depicted and show HTR1B to be a candidate modulator of the mnemonic and motivationally related symptoms in psychiatric illnesses. In order to challenge this assessment, we analyze how and how much the genetic variations located in the gene that codes for HTR1B impacts on the psychiatric phenotypes by reviewing the literature on this topic. We gathered partial evidence arising from genetic association studies, which suggests that HTR1B plays a relevant role in substance-related and obsessive compulsive disorders. On the other hand, no solid evidence for other psychiatric disorders was found. This finding is quite striking because of the heavy impairment of motivation and of mnemonic-related functions (for example, recall bias) that characterize major psychiatric disorders. The possible reasons for the contrast between the prime relevance of HTR1B in regulating memory and motivation and the limited evidence brought by genetic association studies in humans are discussed, and some suggestions for possible future directions are provided.

Design and Experiment of Auxiliary Bearing for Helium Blower of HTR-PM

International Nuclear Information System (INIS)

Yang Guojun; Shi Zhengang; Liu Xingnan; Zhao Jingjing

2014-01-01

The helium blower is the important equipment for HTR-PM. Active magnetic bearing (AMB) instead of mechanical bearing is selected to support the rotor of the helium blower. However, one implication of AMB is the requirement to provide the auxiliary bearing to mitigate the effects of failures or overload conditions. The auxiliary bearing is used to support the rotor when the AMB fails to work. It must support the dropping rotor and bear the great impact force and friction heat. The design of the auxiliary bearing is one of the challenging problems in the whole system. It is very important for the helium blower with AMB of HTR-PM to make success. The rotor’s length of helium blower of HTR-PM is about 3.3 m, its weight is about 4000 kg and the rotating speed is 4000 r/min. The axial load is 4500kg, and the radial load is 1950kg. The angular contact ball bearing was selected as the auxiliary bearing. The test rig has been finished. It is difficult to analyze the falling course of the rotor. The preliminary analysis of the dropping rotor was done in the special condition. The impact force of auxiliary bearing was computed for the axial and radial load. And the dropping test of the blower rotor for HTR-10 will be introduced also in this paper. Results offer the important theoretical base for the protector design of the helium blower with AMB for HTR-PM. (author)

Numerical Simulation of Two-branch Hot Gas Mixing at Reactor Outlet of HTR-PM

International Nuclear Information System (INIS)

Hao Pengefei; Zhou Yangping; Li Fu; Shi Lei; He Heng

2014-01-01

A series of two-branch model experiment has been finished to investigate the thermal mixing efficiency of the HTR-PM reactor outlet. This paper introduces the numerical simulation on the design of thermal mixing structure of HTR-PM and the test facility with Fluent software. The profiles of temperature, pressure and velocity in the mixing structure design and the test facility are discussed by comparing with the model experiment results. The numerical simulation results of the test facility have good agreement to the experiment results. In addition, the thermal-fluid characters obtained by numerical simulation show the thermal mixing structure of HTR-PM has similarity with the test facility. Finally, it is concluded that the thermal mixing design at HTR-PM reactor outlet can fulfilled the requirements for high thermal mixing efficiency and appropriate pressure drop. (author)

PEMODELAN TERAS UNTUK ANALISIS PERHITUNGAN KONSTANTA MULTIPLIKASI REAKTOR HTR-PROTEUS

Directory of Open Access Journals (Sweden)

Zuhair Zuhair

2015-04-01

Full Text Available PTRKN sebagai salah satu unit kerja di BATAN dengan tugas pokok dan fungsi yang berkaitan erat dengan teknologi reaktor dan keselamatan nuklir, menaruh perhatian khusus pada konsep reaktor pebble bed. Dalam makalah ini pemodelan reaktor pebble bed HTR-PROTEUS dilakukan dengan program transport Monte Carlo MCNP5. Partikel bahan bakar berlapis TRISO dimodelkan secara detail dan eksak dimana distribusi acak partikel ini dalam bola bahan bakar didekati menggunakan array teratur kisi SC dengan fraksi packing 5,76% tanpa zona eksklusif. Model teras pebble bed didekati dengan memanfaatkan kisi teratur dari bola yang disusun sebagai kisi BCC berdasarkan sel berulang yang digenerasi dari sejumlah sel satuan. Hasil perhitungan MCNP5 memperlihatkan kesesuaian yang sangat baik dengan eksperimen, walaupun teras HTR-PROTEUS diprediksi lebih reaktif daripada pengukuran, khususnya di teras 4.2 dan 4.3. Pustaka ENDF/B-VI menunjukkan konsistensi dengan estimasi keff paling akurat dibandingkan pustaka ENDF/B-V, terutama ENDF/B-VI (66c. Deviasi estimasi keff yang dihitung dengan eksperimen dikaitkan sebagai konsekuensi dari komposisi reflektor grafit yang dispesifikasikan. Komparasi yang dibuat memperlihatkan bahwa MCNP5 menghasilkan keff teras HTR-PROTEUS lebih presisi daripada hasil dari MCNP4B dan MCNPBALL. Hasil ini menyimpulkan bahwa, sukses metodologi pemodelan ini menjustifikasi aplikasi MCNP5 untuk analisis reaktor pebble bed lainnya. Kata kunci: pemodelan teras HTR-PROTEUS, konstanta multiplikasi, MCNP5   PTRKN as a working unit in BATAN whose main duties and functions are related to reactor technology and nuclear safety, consern attention to pebble bed reactor concept. In this paper modeling of HTR-PROTEUS pebble bed reactor was done using Monte Carlo transport code MCNP5. The TRISO coated fuel particle is modeled in detailed and exact manner where random distributions of these particles in fuel pebble is approximated by using regular array of SC lattice

Reactivity control in HTR power plants with respect to passive safety system. Summary

Energy Technology Data Exchange (ETDEWEB)

Barnert, H; Kugeler, K [Forschungszentrum Juelich GmbH (Germany). Inst. fuer Sicherheitsforschung und Reaktortechnik

1996-12-01

The R and D and Demonstration of the High Temperature Reactor (HTR) is described in overview. The HTR-MODULE power plant, as the most advanced concept, is taken for the description of the reactivity control in general. The idea of the ``modularization of the core`` of the HTR has been developed as the answer on the experiences of the core melt accident at Three Miles Island. The HTR module has two shutdown systems: The ``6 rods``-system for hot shutdown at the ``18 small absorber pebbles units`` - system for cold shutdown. With respect to the definition of ``Passive Systems`` of IAEA-TECDOC-626 the total reactivity control system of the HTR-MODULE is a passive system of category D, because it is an emergency reactor shutdown system based on gravity driven rods, and devices, activated by fail-safe trip logic. But reactivity control of the HTR does not only consist of these engineered safety system but does have a self-acting stabilization by the negative temperature coefficient of the reactivity, being rather effective in reactivity control. Examples from computer calculations are presented, and, in addition, experimental results from the ``Stuck Rod Experiment`` at the AVR reactor in Juelich. On the basis of this the proposal is made that ``self-acting stabilization as a quality of the function`` should be discussed as a new category in addition to the active and passive engineered safety systems, structures and components of IAEA-TECDOC-626. The requirements for a future ``catastrophe-free`` nuclear technology are presented. In the appendix the 7th amendment of the atomic energy act of the Federal Republic of Germany, effective 28 July 94, is given. (author).

The HTR, applications, economics and environmental aspects

International Nuclear Information System (INIS)

Barnert, H.; Schad, M.; Candeli, H.

1990-01-01

The High Temperature Reactor (HTR), as the only nuclear system producing high temperature heat up to 1000 deg. C, offers a wide variety of applications. Besides electricity production, via steam turbines and in future via gas turbines, there is: District heat with high efficiency, long distance energy for urban energy supply, high pressure injection steam production for enhanced oil recovery, medium range temperature heat direct application in chemical and related industry and last not least, high temperature application for the refinement of fossil energy carriers. Recent results of studies and programmes will be presented: Near term applications are identified, e.g. refineries and alumina industry with smaller HTR units. Another large market is the production of hydrogen, methanol and ammonia on the basis of natural gas, the relevant technology has been developed up to the pilot scale. The refinement of fossil energy carriers, in particular of coal, is subject of the R+D programme in the cooperation between German industrial companies and the Nuclear Research Center. The results are very promising and will be explained in detail. This programme will be continued. Objectives are: improvement of the technology and of the economics as well as environmental aspects, e.g. the reduction of emissions of carbon-dioxid. The topics of the programme deal with the different apparatus, e.g. steam methane reformer, steam coal gasifier, intermediate heat exchanger and last not least, the process heat HTR. (author)

Studi Model Benchmark Mcnp6 Dalam Perhitungan Reaktivitas Batang Kendali Htr-10

OpenAIRE

Jupiter S.Pane, Zuhair, Suwoto, Putranto Ilham Yazid

2016-01-01

STUDI MODEL BENCHMARK MCNP6 DALAM PERHITUNGAN REAKTIVITAS BATANG KENDALI HTR-10. Dalam operasi reaktor nuklir, sistem batang kendali memainkan peranan yang sangat penting karena didesain untuk mengendalikan reaktivitas teras dan memadamkan reaktor. Nilai reaktivitas batang kendali harus diprediksi secara akurat melalui eksperimen dan perhitungan. Makalah ini mendiskusikan model Benchmark dalam perhitungan reaktivitas batang kendali reaktor HTR-10. Perhitungan dikerjakan dengan program transpo...

High Temperature Reactor (HTR) Deep Burn Core and Fuel Analysis: Design Selection for the Prismatic Block Reactor

Energy Technology Data Exchange (ETDEWEB)

Francesco Venneri; Chang-Keun Jo; Jae-Man Noh; Yonghee Kim; Claudio Filippone; Jonghwa Chang; Chris Hamilton; Young-Min Kim; Ji-Su Jun; Moon-Sung Cho; Hong-Sik Lim; MIchael A. Pope; Abderrafi M. Ougouag; Vincent Descotes; Brian Boer

2010-09-01

The Deep Burn (DB) Project is a U.S. Department of Energy sponsored feasibility study of Transuranic Management using high burnup fuel in the high temperature helium cooled reactor (HTR). The DB Project consists of seven tasks: project management, core and fuel analysis, spent fuel management, fuel cycle integration, TRU fuel modeling, TRU fuel qualification, and HTR fuel recycle. In the Phase II of the Project, we conducted nuclear analysis of TRU destruction/utilization in the HTR prismatic block design (Task 2.1), deep burn fuel/TRISO microanalysis (Task 2.3), and synergy with fast reactors (Task 4.2). The Task 2.1 covers the core physics design, thermo-hydraulic CFD analysis, and the thermofluid and safety analysis (low pressure conduction cooling, LPCC) of the HTR prismatic block design. The Task 2.3 covers the analysis of the structural behavior of TRISO fuel containing TRU at very high burnup level, i.e. exceeding 50% of FIMA. The Task 4.2 includes the self-cleaning HTR based on recycle of HTR-generated TRU in the same HTR. Chapter IV contains the design and analysis results of the 600MWth DB-HTR core physics with the cycle length, the average discharged burnup, heavy metal and plutonium consumptions, radial and axial power distributions, temperature reactivity coefficients. Also, it contains the analysis results of the 450MWth DB-HTR core physics and the analysis of the decay heat of a TRU loaded DB-HTR core. The evaluation of the hot spot fuel temperature of the fuel block in the DB-HTR (Deep-Burn High Temperature Reactor) core under full operating power conditions are described in Chapter V. The investigated designs are the 600MWth and 460MWth DB-HTRs. In Chapter VI, the thermo-fluid and safety of the 600MWth DB-HTRs has been analyzed to investigate a thermal-fluid design performance at the steady state and a passive safety performance during an LPCC event. Chapter VII describes the analysis results of the TRISO fuel microanalysis of the 600MWth and 450

HTR process heat applications, status of technology and economical potential

International Nuclear Information System (INIS)

Barnet, H.

1997-01-01

The technical and industrial feasibility of the production of high temperature heat from nuclear fuel is presented. The technical feasibility of high temperature heat consuming processes is reviewed and assessed. The conclusion is drawn that the next technological step for pilot plant scale demonstration is the nuclear heated steam reforming process. The economical potential of HTR process heat applications is reviewed: It is directly coupled to the economical competitiveness of HTR electricity production. Recently made statements and pre-conditions on the economic competitiveness in comparison to world market coal are reported. (author). 8 figs

Burner and dissolver off-gas treatment in HTR fuel reprocessing

International Nuclear Information System (INIS)

Barnert-Wiemer, H.; Heidendael, M.; Kirchner, H.; Merz, E.; Schroeder, G.; Vygen, H.

1979-01-01

In the reprocessing of HTR fuel, essentially all of the gaseous fission products are released during the heat-end tratment, which includes burning of the graphite matrix and dissolving of the heavy metallic residues in THOREX reagent. Three facilities for off-gas cleaning are described, the status of the facility development and test results are reported. Hot tests with a continuous dissolver for HTR-type fuel (throughput 2 kg HM/d) with a closed helium purge loop have been carried out. Preliminary results of these experiments are reported

Study on the production mechanism of Co-60 in the primary loop of HTR-10

International Nuclear Information System (INIS)

Wang Shouang; Xie Feng; Li Hong; Cao Jianzhu; Li Fu; Wei Liqiang

2015-01-01

Co-60 is an activated metallic erosion product, which is very important for waste management and decommissioning work of pressurized water reactor (PWR) power plants. Recent measurement on the samples from the primary loop of HTR-10 indicates the existence of Co-60. In current paper, the preliminary experimental results in HTR-10 will be introduced, and the production mechanism of Co-60 in the pebble bed high temperature gas-cooled reactors will be summarized and compared with that in PWRs and Germany High Temperature Nuclear Reactor (AVR). The further experiments with decomposing the post-irradiation graphite spheres of HTR-10 are put forward, which will promote the further study to testify the production sources of Co-60 and be of great significance in the waste minimization and the decommissioning work of HTR-10. (author)

Dual regulatory switch confers tighter control on HtrA2 proteolytic activity.

Science.gov (United States)

Singh, Nitu; D'Souza, Areetha; Cholleti, Anuradha; Sastry, G Madhavi; Bose, Kakoli

2014-05-01

High-temperature requirement protease A2 (HtrA2), a multitasking serine protease that is involved in critical biological functions and pathogenicity, such as apoptosis and cancer, is a potent therapeutic target. It is established that the C-terminal post-synaptic density protein, Drosophila disc large tumor suppressor, zonula occludens-1 protein (PDZ) domain of HtrA2 plays pivotal role in allosteric modulation, substrate binding and activation, as commonly reported in other members of this family. Interestingly, HtrA2 exhibits an additional level of functional modulation through its unique N-terminus, as is evident from 'inhibitor of apoptosis proteins' binding and cleavage. This phenomenon emphasizes multiple activation mechanisms, which so far remain elusive. Using conformational dynamics, binding kinetics and enzymology studies, we addressed this complex behavior with respect to defining its global mode of regulation and activity. Our findings distinctly demonstrate a novel N-terminal ligand-mediated triggering of an allosteric switch essential for transforming HtrA2 to a proteolytically competent state in a PDZ-independent yet synergistic activation process. Dynamic analyses suggested that it occurs through a series of coordinated structural reorganizations at distal regulatory loops (L3, LD, L1), leading to a population shift towards the relaxed conformer. This precise synergistic coordination among different domains might be physiologically relevant to enable tighter control upon HtrA2 activation for fostering its diverse cellular functions. Understanding this complex rheostatic dual switch mechanism offers an opportunity for targeting various disease conditions with tailored site-specific effector molecules. © 2014 FEBS.

Vers une décentralisation de la gestion de l’eau froide en habitat collectif : la question de la généralisation du comptage individuel à Paris

Directory of Open Access Journals (Sweden)

Agathe Euzen

2004-10-01

Full Text Available La gestion de l’eau froide en habitat collectif tend à évoluer en France étant donné la nouvelle réglementation en vigueur. Mieux maîtriser l’eau, responsabiliser les usagers de leurs consommations, assurer une plus grande équité… sont les arguments avancés pour favoriser la généralisation du comptage individuel. Cependant, la décentralisation de la gestion de l’eau froide en habitat collectif génère de nombreuses questions d’ordre technique, économique et social et ouvre de nouvelles réflexions sur la circulation de l’eau dans un immeuble et l’évolution des relations entre les différents acteurs.

The challenge of introducing HTR plants on to the international power plant market

International Nuclear Information System (INIS)

Bogen, J.; Stoelzl, D.

1987-01-01

The international power plant market today is characterized by high increase in energy consumption for developing countries with limitations of investment capital and low increase in energy consumption for industrialized countries with limitations of additional power plant capacities. As a consequence there is a low demand for large new power stations. This leads to a tendency for small and medium sized power plant units - meeting high environmental standards - for which the total investment volume is low and full load operation of a plant can be realized earlier due to the small block capacity. - For nuclear power plants the High-Temperature-Reactor (HTR)-line with spherical fuel elements and a core structure of graphite is specially suited for this small and medium sized nuclear reactor (SMSNR) capacity. The excellent safety characteristics, the high availability, the low radiation doses for the operation personnel and the environment of the HTR line has been demonstrated by 20 years of operation of the AVR-15 MWe experimental power plant in Juelich F.R.G. and since 1985 by operation of the THTR-300 MWe prototype plant at Hamm-Uentrop F.R.G. Up-dated concepts of the HTR-line are under design for electricity generation (HTR-500), for co-generation of power and heat (HTR-100) and for district heating purposes only (GHR-10). By implementing two HTR projects the Brown Boveri Group is in the position to realize the collected experiences from design, licensing, erection, commissioning and operation for the follow-on projects. This leads to practical and sound technical solutions convenient for existing manufacturing processes, well known materials, standardized components and usual manufacturing tolerances. Specific plant characteristics can be used for advantages in the competition. (author)

Design of the steam reformer for the HTR-10 high temperature process heat application

International Nuclear Information System (INIS)

Ju Huaiming; Xu Yuanhui; Jia Haijun

2000-01-01

The 10 MW High Temperature Reactor Test Module (HTR-10) is being constructed now and planned to be operational in 2000. One of the objectives is to develop the high temperature process heat application. The methane steam reformer is one of the key-facilities for the nuclear process heat application system. The paper describes the conceptual design of the HTR-10 Steam Reformer with He heating, and the design optimization computer code. It can be used to perform sensitivity analysis for parameters, and to improve the design. Principal parameters and construction features of the HTR-10 reformer heated by He are introduced. (author)

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1

Energy Technology Data Exchange (ETDEWEB)

Kieper, Nicole; Holmstroem, Kira M.; Ciceri, Dalila; Fiesel, Fabienne C. [Center of Neurology and Hertie Institute for Clinical Brain Research, 72076 Tuebingen (Germany); Wolburg, Hartwig [Institute of Pathology, University of Tuebingen, 72076 Tuebingen (Germany); Ziviani, Elena; Whitworth, Alexander J. [Medical Research Council Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN (United Kingdom); Martins, L. Miguel [Cell Death Regulation Laboratory, MRC Toxicology Unit, Leicester LE1 9HN (United Kingdom); Kahle, Philipp J., E-mail: philipp.kahle@uni-tuebingen.de [Center of Neurology and Hertie Institute for Clinical Brain Research, 72076 Tuebingen (Germany); Krueger, Rejko, E-mail: rejko.krueger@uni-tuebingen.de [Center of Neurology and Hertie Institute for Clinical Brain Research, 72076 Tuebingen (Germany)

2010-04-15

Loss of Omi/HtrA2 function leads to nerve cell loss in mouse models and has been linked to neurodegeneration in Parkinson's and Huntington's disease. Omi/HtrA2 is a serine protease released as a pro-apoptotic factor from the mitochondrial intermembrane space into the cytosol. Under physiological conditions, Omi/HtrA2 is thought to be involved in protection against cellular stress, but the cytological and molecular mechanisms are not clear. Omi/HtrA2 deficiency caused an accumulation of reactive oxygen species and reduced mitochondrial membrane potential. In Omi/HtrA2 knockout mouse embryonic fibroblasts, as well as in Omi/HtrA2 silenced human HeLa cells and Drosophila S2R+ cells, we found elongated mitochondria by live cell imaging. Electron microscopy confirmed the mitochondrial morphology alterations and showed abnormal cristae structure. Examining the levels of proteins involved in mitochondrial fusion, we found a selective up-regulation of more soluble OPA1 protein. Complementation of knockout cells with wild-type Omi/HtrA2 but not with the protease mutant [S306A]Omi/HtrA2 reversed the mitochondrial elongation phenotype and OPA1 alterations. Finally, co-immunoprecipitation showed direct interaction of Omi/HtrA2 with endogenous OPA1. Thus, we show for the first time a direct effect of loss of Omi/HtrA2 on mitochondrial morphology and demonstrate a novel role of this mitochondrial serine protease in the modulation of OPA1. Our results underscore a critical role of impaired mitochondrial dynamics in neurodegenerative disorders.

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1

International Nuclear Information System (INIS)

Kieper, Nicole; Holmstroem, Kira M.; Ciceri, Dalila; Fiesel, Fabienne C.; Wolburg, Hartwig; Ziviani, Elena; Whitworth, Alexander J.; Martins, L. Miguel; Kahle, Philipp J.; Krueger, Rejko

2010-01-01

Loss of Omi/HtrA2 function leads to nerve cell loss in mouse models and has been linked to neurodegeneration in Parkinson's and Huntington's disease. Omi/HtrA2 is a serine protease released as a pro-apoptotic factor from the mitochondrial intermembrane space into the cytosol. Under physiological conditions, Omi/HtrA2 is thought to be involved in protection against cellular stress, but the cytological and molecular mechanisms are not clear. Omi/HtrA2 deficiency caused an accumulation of reactive oxygen species and reduced mitochondrial membrane potential. In Omi/HtrA2 knockout mouse embryonic fibroblasts, as well as in Omi/HtrA2 silenced human HeLa cells and Drosophila S2R+ cells, we found elongated mitochondria by live cell imaging. Electron microscopy confirmed the mitochondrial morphology alterations and showed abnormal cristae structure. Examining the levels of proteins involved in mitochondrial fusion, we found a selective up-regulation of more soluble OPA1 protein. Complementation of knockout cells with wild-type Omi/HtrA2 but not with the protease mutant [S306A]Omi/HtrA2 reversed the mitochondrial elongation phenotype and OPA1 alterations. Finally, co-immunoprecipitation showed direct interaction of Omi/HtrA2 with endogenous OPA1. Thus, we show for the first time a direct effect of loss of Omi/HtrA2 on mitochondrial morphology and demonstrate a novel role of this mitochondrial serine protease in the modulation of OPA1. Our results underscore a critical role of impaired mitochondrial dynamics in neurodegenerative disorders.

Survey of appropriate endothermic processes for association with the HTR

International Nuclear Information System (INIS)

Brown, G.; Harrison, G.E.; Gent, C.W.; Plummer, J.

1975-01-01

Emphasis is placed on association of the HTR system as a heat source with chemical processes requiring temperatures up to 850 to 900 0 C, corresponding to a reactor coolant temperature of 950 0 C, though processes requiring temperatures up to 1100 0 C and above are reviewed. Particular attention is given to processes for the production of hydrogen-containing gases, including coal/lignite gasification which has been the subject of a recent study. Rising fuel prices make the HTR an attractive proposition if design concepts and materials can be developed to match the requirements. Other appropriate endothermic processes considered are oil processing, including tar sands and shales, and also energy production. Since the full temperature range of the reactor system must be utilised mention is made of low grade heat uses. Even very large chemical works have relatively small energy requirement by nuclear heat standards and adoption of the HTR as a heat source is likely only if it is associated with a large chemical/metallurgical complex or with the processing of a natural resource. (author)

Analysis on First Criticality Benchmark Calculation of HTR-10 Core

International Nuclear Information System (INIS)

Zuhair; Ferhat-Aziz; As-Natio-Lasman

2000-01-01

HTR-10 is a graphite-moderated and helium-gas cooled pebble bed reactor with an average helium outlet temperature of 700 o C and thermal power of 10 MW. The first criticality benchmark problem of HTR-10 in this paper includes the loading number calculation of nuclear fuel in the form of UO 2 ball with U-235 enrichment of 17% for the first criticality under the helium atmosphere and core temperature of 20 o C, and the effective multiplication factor (k eff ) calculation of full core (5 m 3 ) under the helium atmosphere and various core temperatures. The group constants of fuel mixture, moderator and reflector materials were generated with WlMS/D4 using spherical model and 4 neutron energy group. The critical core height of 150.1 cm obtained from CITATION in 2-D R-Z reactor geometry exists in the calculation range of INET China, JAERI Japan and BATAN Indonesia, and OKBM Russia. The k eff calculation result of full core at various temperatures shows that the HTR-10 has negative temperature coefficient of reactivity. (author)

Characteristic analysis of rotor dynamics and experiments of active magnetic bearing for HTR-10GT

International Nuclear Information System (INIS)

Yang Guojun; Xu Yang; Shi Zhengang; Gu Huidong

2005-01-01

A 10 MW high-temperature gas-cooled reactor (HTR-10) was constructed by the Institute of Nuclear and New Energy Technology (INET) at Tsinghua University of China. The helium turbine and generator system of 10 MW high temperature gas-cooled reactor (HTR-10GT) is the second phase for the HTR-10 project. It is to set up a direct helium cycle to replace the current steam cycle. The active magnetic bearing (AMB) instead of ordinary mechanical bearing was chosen to support the rotor in the HTR-10GT. This rotor is vertically mounted to hold the turbine machine, compressors and the power generator together. The rotor's length is 7 m, its weight is about 1500 kg and the rotating speed is 15000 r/min. The structure of the rotor is so complicated that dynamic analysis of the rotor becomes difficult. One of the challenging problems is to exceed natural frequencies with enough stability and safety during reactor start up, power change and shutdown. The dynamic analysis of the rotor is the base for the design of control system. It is important for the rotor to exceed critical speeds. Some kinds of software and methods, such as MSC.Marc, Ansys, and the Transfer Matrix Method, are compared to fully analyze rotor dynamics characteristic in this paper. The modal analysis has been done for the HTR-10GT rotor. MSC.Marc was finally selected to analyze the vibration mode and the natural frequency of the rotor. The effects of AMB stiffness on the critical speeds of the rotor were studied. The design characteristics of the AMB control system for the HTR-10GT were studied and the related experiment to exceed natural frequencies was introduced. The experimental results demonstrate the system functions and validate the control scheme, which will be used in the HTR-10GT project. (authors)

Development status of the HTGR in the world. Outline and construction status of the demonstration HTGR program (HTR-PM) of China

International Nuclear Information System (INIS)

Ohashi, Kazutaka; Okamoto, Futoshi; Mouri, Tomoaki; Saito, Masanao; Nishio, Hiroki; Ohashi, Junpei

2014-01-01

Based on successful construction and operation experiences of HTR-10 reactor with pebble bed fuel and helium coolant, HTR-PM (HTR Pebble-bed Modular) reactor program was under way with 200 MWe of twin reactors with the same core configuration as HTR-10 reactor, which, each with a single steam generator, would drive a single steam turbine. Core height was 11 meters, and main steam temperature would be at 566 C. Although HTR-PM reactor program was interrupted by effects of the Fukushima accident, first concrete basement construction was started in December 2012 with aiming at connecting the Grid in 2017. This article reviewed outline and construction status of HTR-PM reactor in China. (T. Tanaka)

Progress and problems in modelling HTR core dynamics

International Nuclear Information System (INIS)

Scherer, W.; Gerwin, H.

1991-01-01

In recent years greater effort has been made to establish theoretical models for HTR core dynamics. At KFA Juelich the TINTE (TIme dependent Neutronics and TEmperatures) code system has been developed, which is able to model the primary circuit of an HTR plant using modern numerical techniques and taking into account the mutual interference of the relevant physical variables. The HTR core is treated in 2-D R-Z geometry for both nucleonics and thermo-fluid-dynamics. 2-energy-group diffusion theory is used in the nuclear part including 6 groups of delayed neutron precursors and 14 groups of decay heat producers. Local and non-local heat sources are incorporated, thus simulating gamma ray transport. The thermo-fluid-dynamics module accounts for heterogeneity effects due to the pebble bed structure. Pipes and other components of the primary loop are modelled in 1-D geometry. Forced convection may be treated as well as natural convection in case of blower breakdown accidents. Validation of TINTE has started using the results of a comprehensive experimental program that has been performed at the Arbeitsgemeinschaft Versuchsreaktor GmbH (AVR) high temperature pebble bed reactor at Juelich. In the frame of this program power transients were initiated by varying the helium blower rotational speed or by moving the control rods. In most cases a good accordance between experiment and calculation was found. Problems in modelling the special AVR reactor geometry in two dimensions are described and suggestions for overcoming the uncertainties of experimentally determined control rod reactivities are given. The influence of different polynomial expansions of xenon cross sections to long term transients is discussed together with effects of burnup during that time. Up to now the TINTE code has proven its general applicability to operational core transients of HTR. The effects of water ingress on reactivity, fuel element corrosion and cooling gas properties are now being

Applications and Prospects of Modularization Technology in HTR Project Starting from Primary Loop Cavity Construction

International Nuclear Information System (INIS)

Yang Guokang; Chen Jing; Huang Wen; Lin Lizhi; Sun Yunlun; Chen Yan; Mao Jiaxin; Wang Yougang; Wang Jinwen; Lin Mingfeng; Yang Mingshan

2014-01-01

Primary loop cavity is one of the key areas and major difficulties in HTR-PM project construction. In order to shorten the construction schedule and improve the construction quality, researches on modular design and construction of primary loop cavity has been carried out and the results have been applied in HTR-PM project construction, and got significant application benefit. This paper summarizes the modularization technology application research and project implementation results of primary loop cavity, and analyzes the application and prospects of modularization technology in the HTR project construction. (author)

Fuel cycle studies for the Dragon HTR

Energy Technology Data Exchange (ETDEWEB)

Desoisa, J A; Nunn, R M; Twitchin, A E

1971-02-15

This note reports the progress made at B.N.L. in the study of the fuel cycle for the HTR design described by Daub (1970). The primary purpose of the study is to examine the special problems of the approach to equilibrium fuel cycle.

The physics design of the HTR-1160

International Nuclear Information System (INIS)

Huebner, A.; Brandes, S.

1975-01-01

This paper describes the physica design of the reactor core of the helium cooled, graphite moderated high-temperature reactor HTR-1160. A discussion is given of the design criteria, the calculational methods, the burnup cycle, the power distribution and the reactivity control. (orig.) [de

Reactor physics calculations on HTR type configurations

Energy Technology Data Exchange (ETDEWEB)

Klippel, H.T.; Hogenbirk, A.; Stad, R.C.L. van der; Janssen, A.J.; Kuijper, J.C.; Levin, P.

1995-04-01

In this paper a short description of the ECN nuclear analysis code system is given with respect to application in HTR reactor physics calculations. First results of calculations performed on the PROTEUS benchmark are shown. Also first results of a HTGR benchmark are given. (orig.).

Reactor physics calculations on HTR type configurations

International Nuclear Information System (INIS)

Klippel, H.T.; Hogenbirk, A.; Stad, R.C.L. van der; Janssen, A.J.; Kuijper, J.C.; Levin, P.

1995-04-01

In this paper a short description of the ECN nuclear analysis code system is given with respect to application in HTR reactor physics calculations. First results of calculations performed on the PROTEUS benchmark are shown. Also first results of a HTGR benchmark are given. (orig.)

Two-branch Gas Experiments for Hot Gas Mixing of HTR-PM

International Nuclear Information System (INIS)

Zhou Yangping; Hao Pengefei; He Heng; Li Fu; Shi Lei

2014-01-01

A model experiment is proposed to investigate the hot gas mixing efficiency of HTR-PM reactor outlet. The test facility is introduced which is set at a scale of 1:2.5 comparing with the design of thermal mixing structure at HTR-PM reactor outlet. The test facility using air as its flow media includes inlet pipe system, electric heaters, main body of test facility, hot gas duct, exhaust pipe system and I&C system. Two-branch gas experiments are conducted on the test facility and the values of thermal-fluid parameters are collected and analyzed which include the temperature, pressure and velocity of the flow as well as the temperature of the tube wall. The analysis result shows the mixing efficiency is higher than the requirement of thermal mixing by steam generator even with conservative assumption which indicates that the design of hog gas mixing structure of HTR-PM fulfills the requirement for thermal mixing at two-branch working conditions. (author)

Calculation of HTR-10 first criticality with MVP

International Nuclear Information System (INIS)

Xie Jiachun; Yao Lianying

2015-01-01

The first criticality of 10 MW pebble-bed high temperature gas-cooled reactor-test module (HTR-10) was calculated with MVP. According to the characteristics of HTR-10, the Statistical Geometry Model of MVP was employed to describe the random arrangement of coated fuel particles in the fuel pebbles and the random distribution of the fuel and dummy pebbles in the core. Compared with previous results from VSOP and MCNP, the MVP results with JENDL-3.3 library were little more different, but the results with ENDF/B-Ⅵ.8 library were very close. The relative errors were less than 0.7%, compared with the first criticality experimental results. The study shows that MVP could be used in the physics calculations for pebble bed high temperature gas-cooled reactors. (authors)

Review on characterization methods applied to HTR-fuel element components

International Nuclear Information System (INIS)

Koizlik, K.

1976-02-01

One of the difficulties which on the whole are of no special scientific interest, but which bear a lot of technical problems for the development and production of HTR fuel elements is the proper characterization of the element and its components. Consequently a lot of work has been done during the past years to develop characterization procedures for the fuel, the fuel kernel, the pyrocarbon for the coatings, the matrix and graphite and their components binder and filler. This paper tries to give a status report on characterization procedures which are applied to HTR fuel in KFA and cooperating institutions. (orig.) [de

The safety characteristics of the HTR 500 reactor plant

International Nuclear Information System (INIS)

Wachholz, W.

1987-01-01

The HTR is a reactor having a passive safety. It is equipped with the usual active engineered safety systems in simplified form. Due to its inherent safety characteristics and the burst-safe prestressed concrete reactor vessel activity containment is ensured even without the effect of active safety systems. Even in the event of extremely hypothetical accidents the effect on the environment is low enough so that evacuation or relocation of the population is not required. Therefore large-scale damage of agricultural land and industrially used areas is safely ruled out. Thus the site selection for this type of reactor is not restricted i.e. an HTR can be constructed near industrial and urban center. (author)

Analysis of aging mechanism and management for HTR-PM reactor pressure vessel

International Nuclear Information System (INIS)

Sun Yunxue; Shao Jin

2015-01-01

Reactor pressure vessel is an important part of the reactor pressure boundary, its important degree ranks high in ageing management and life assessment of nuclear power plant. Carrying out systematic aging management to ensure reactor pressure vessel keeping enough safety margins and executing design functions is one of the key factors to guarantee security and stability operation for nuclear power plant during the whole lifetime and prolong life. This paper briefly introduces the structure and aging mechanism of reactor pressure vessel in pressurized water reactor nuclear power plant, and introduces the design principle and structure characteristics of HTR-PM. At the same time, this paper carries out preliminary analysis and exploration. and discusses aging management of HTR-PM reactor pressure vessel. Finally, the advice of carring out aging management for HTR-PM reactor pressure vessel is proposed. (authors)

In-situ hybridization based quantification of hTR: a possible biomarker in malignant melanoma

DEFF Research Database (Denmark)

Vagner, Josephine; Steiniche, Torben; Stougaard, Magnus

2015-01-01

thickness suggesting that hTR might be a valuable biomarker in MM. Furthermore, as ISH-based detection requires presence of both hTR and the reverse transcriptase (hTERT) it might be an indicator of active telomerase and thus have future relevance as a predictive biomarker for anti-telomerase treatment....

Actual characteristics study on HTR-10GT coupling with direct gas turbine cycle

International Nuclear Information System (INIS)

Peng Xuechuang; Zhu Shutang; Wang Jie

2005-01-01

HTR-10GT is a testing project coupling the reactor HTR-10 with direct gas turbine cycle. Its thermal cycle can be taken as a closed, recuperated and inter-cooled Brayton cycle. The present study is focused on the thermal cycle performance of HTR-10GT under practical conditions of leakage, pressure losses, etc.. Through thermodynamic analysis, the expression of cycle efficiency for actual thermal cycle is derived. By establishing a physical model with friction loss and leakage, a set of governing equation are constructed based on some reasonable assumptions. The results of actual cycle efficiency have been calculated for different leakage amount at different locations while the effects of leakage under different power level have also been calculated and analyzed. (authors)

Fission Product Releases from a Core into a Coolant of a Prismatic 350-MWth HTR

Energy Technology Data Exchange (ETDEWEB)

Kim, Young Min; Jo, C. K. [KAERI, Daejeon (Korea, Republic of)

2016-05-15

A prismatic 350-MW{sub th} high temperature reactor (HTR) is a means to generate electricity and process heat for hydrogen production. The HTR will be operated for an extended fuel burnup of more than 150 GWd/MTU. Korea Atomic Energy Research Institute (KAERI) is performing a point design for the HTR which is a pre-conceptual design for the analysis and assessment of engineering feasibility of the reactor. In a prismatic HTR, metallic and gaseous fission products (FPs) are produced in the fuel, moved through fuel materials, and released into a primary coolant. The FPs released into the coolant are deposited on the various helium-wetted surfaces in the primary circuit, or they are sorbed on particulate matters in the primary coolant. The deposited or sorbed FPs are released into the environment through the leakage or venting of the primary coolant. It is necessary to rigorously estimate such radioactivity releases into the environment for securing the health and safety of the occupational personnel and the public. This study treats the FP releases from a core into a coolant of a prismatic 350-MW{sub th} HTR. These results can be utilized as input data for the estimation of FP migration from a coolant into the environment. The analysis of fission product release within a prismatic 350-MW{sub th} HTR has been done. It was assumed that the HTR was operated at constant temperature and power for 1500 EFPDs. - The final burnup is 152 GWd/tHM at packing fraction of 25 %, and the final fast fluence is about 8 X 10{sup 21} n/cm{sup 2}, E{sub n} > 0.1 MeV. - The temperatures at the compact center and at the center of a kernel located at the compact center are 884 and 893 .deg. C, respectively, when the packing fraction is 25 % and the coolant temperature is 850 .deg. C. - Xenon is the most radioactive fission product in a coolant of a prismatic HTR when there are broken TRISOs and fuel component contaminated with heavy metals. For metallic fission products, the radioactivity

HTR Plans in Poland

International Nuclear Information System (INIS)

Sobolewski, Józef

2017-01-01

Target for HTR: Polish Heat Market: Today 100% heat market is dominated by fossil fuels; mostly coal in district heating and coal and gas in industry heat generation. Huge potential for nuclear reactors Currently can be addressed only in terms of LWR, i.e. T <250 ° C, useful in district heating, but not in industry. Need for new technologies •HTGR (High Temperature Gas Reactor) ~600°C, e.g. for industry steam generation. •VHTR (Very High Temperature Reactor), ... ~1000°C, e.g. for hydrogen production

Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi Protease and Its Mutated Variants.

Directory of Open Access Journals (Sweden)

Artur Gieldon

Full Text Available HtrA2(Omi protease controls protein quality in mitochondria and plays a major role in apoptosis. Its HtrA2S306A mutant (with the catalytic serine routinely disabled for an X-ray study to avoid self-degradation is a homotrimer whose subunits contain the serine protease domain (PD and the regulatory PDZ domain. In the inactive state, a tight interdomain interface limits penetration of both PDZ-activating ligands and PD substrates into their respective target sites. We successfully crystalized HtrA2V226K/S306A, whose active counterpart HtrA2V226K has had higher proteolytic activity, suggesting higher propensity to opening the PD-PDZ interface than that of the wild type HtrA2. Yet, the crystal structure revealed the HtrA2V226K/S306A architecture typical of the inactive protein. To get a consistent interpretation of crystallographic data in the light of kinetic results, we employed molecular dynamics (MD. V325D inactivating mutant was used as a reference. Our simulations demonstrated that upon binding of a specific peptide ligand NH2-GWTMFWV-COOH, the PDZ domains open more dynamically in the wild type protease compared to the V226K mutant, whereas the movement is not observed in the V325D mutant. The movement relies on a PDZ vs. PD rotation which opens the PD-PDZ interface in a lid-like (budding flower-like in trimer fashion. The noncovalent hinges A and B are provided by two clusters of interfacing residues, harboring V325D and V226K in the C- and N-terminal PD barrels, respectively. The opening of the subunit interfaces progresses in a sequential manner during the 50 ns MD simulation. In the systems without the ligand only minor PDZ shifts relative to PD are observed, but the interface does not open. Further activation-associated events, e.g. PDZ-L3 positional swap seen in any active HtrA protein (vs. HtrA2, were not observed. In summary, this study provides hints on the mechanism of activation of wtHtrA2, the dynamics of the inactive HtrA2V325D

Burn-up measurement in the HTR-module-reactor

International Nuclear Information System (INIS)

Gerhards, E.

1993-05-01

The burn-up status of spherical HTR-fuel elements is determined by a γ-spectrometric analysis of Cs-137 activity. The γ-spectrum recorded by a semiconductor detector up to now is analyzed by complex mathematical and time-consuming methods. For the operation of the HTR-Module-Reactor, however, a fast evaluation of the burn-up status is necessary. It is shown that this can be ensured by a comparison between the measured spectra and simulation results. Using the computer-program HTROGEN and the program system SPECCALC especially developed for this problem the γ-spectra are evaluated as a function of the burn-up status. The method is applied to results available from the operation of the AVR-reactor. The burn-up status determined with different methods corresponds very well within the limits of accuracy. (orig.)

Coal conversion and the HTR - basic elements of novel power supply concepts

International Nuclear Information System (INIS)

Buerger, F.H.

1985-01-01

A meeting under this title was held in Dortmund on 16 to 19 September, 1985, jointly by the VGB Technische Vereinigung der Grosskraftwerksbetreiber e.V., Essen, and the Vereinigte Elektrizitaetswerke Westfalen AG (VEW), Dortmund. The meeting was held in two sections: 'Gersteinwerk power plant - the combination unit K and the KUV coal conversion system' and '7th International conference on HTR technology'. Three technologies were discussed that will have a significant role on the future energy market, i.e., the HTR reactor line (first applied in the Hamm-Uentrop THTR reactor), the new generation of coal-fired power plants with combined gas/steam turbines, and the coal gasification technology. All three systems will make more efficient and less-polluting use of domestic coal by using HTR process heat, by converting coal to widen its range of applications, and by providing more efficient combination units for power plants. (orig./UA) [de

SGN-Reseau Eurisys participates to the Hanford military site rehabilitation

International Nuclear Information System (INIS)

Anon.

1996-01-01

Numatec Hanford Corporation, a subsidiary company of SGN-Reseau Eurisys and Cogema, gained with Fluor Daniel the contract for the rehabilitation of the old military nuclear centre of Hanford (Washington, USA). This contract of 5 years represents 5 billions of US dollars with 300 millions of dollars for the French part. This short paper gives a general description of the Hanford installations and of the partners involved in the contract: Fluor Daniel consortium, Lockheed Martin, Babcock and Wilcox, Duke Engineering and Services, Rust Federal Services, Numatec Hanford Corporation (NHC), SGN-Eurisys Services Corporation (SESC). The schedule comprises: the stabilisation of the residual plutonium in all installations before December 1999, the removal of muds and debris from the K storage pool of irradiated fuels before June 2000, the draining and cleaning of the high activity storage tanks before December 2001 and the general decontamination of the installations up to the year 2005. (J.S.)

Energy analysis of control rod drive mechanism in HTR-10

International Nuclear Information System (INIS)

Bo Hanliang; Wu Yuanqiang

2000-01-01

This paper presents a theoretical model for the control rod drive mechanism for the 10 MW High Temperature Gas Cooled Reactor (HTR-10) and analyzes accidents which may occur in the drive mechanism, for example, chain break, coupling damage and other damage scenarios. The results show that the matching problem between buffer capability and coupling strength is the main reason for coupling damage; increased temperatures would reduce eddy damping and cause a mismatch between buffer capability and coupling strength; and the displacement of the buffer spring will affect the coupling force. The results provide a theoretical basis for the design of the control rod drive mechanism for HTR-10

Design of reactor protection systems for HTR plants generating electric power and process heat problems and solutions

International Nuclear Information System (INIS)

Craemer, B.; Dahm, H.; Spillekothen, H.G.

1982-06-01

The design basis of the reactor protection system (RPS) for HTR plants generating process heat and electric power is briefly described and some particularities of process heat plants are indicated. Some particularly important or exacting technical measuring positions for the RPS of a process heat HTR with 500 MWsub(th) power (PNP 500) are described and current R + D work explained. It is demonstrated that a particularly simple RPS can be realized in an HTR with modular design. (author)

First Results for Fluid Dynamics, Neutronics and Fission Product Behaviour in HTR applying the HTR Code Package (HCP) Prototype

International Nuclear Information System (INIS)

Allelein, H.-J.; Kasselmann, S.; Xhonneux, A.; Lambertz, D.

2014-01-01

To simulate the different aspects of High Temperature Reactor (HTR) cores, a variety of specialized computer codes have been developed at Forschungszentrum Jülich (IEK-6) and Aachen University (LRST) in the last decades. In order to preserve knowledge, to overcome present limitations and to make these codes applicable to modern computer clusters, these individual programs are being integrated into a consistent code package. The so-called HTR code package (HCP) couples the related and recently applied physics models in a highly integrated manner and therefore allows to simulate phenomena with higher precision in space and time while at the same time applying state-of-the-art programming techniques and standards. This paper provides an overview of the status of the HCP and reports about first benchmark results for an HCP prototype which couples the fluid dynamics and time dependent neutronics code MGT-3D, the burn up code TNT and the fission product release code STACY. Due to the coupling of MGT-3D and TNT, a first step towards a new reactor operation and accident simulation code was made, where nuclide concentrations calculated by TNT are fed back into a new spectrum code of the HCP. Selected operation scenarios of the HTR-Module 200 concept plant and the HTTR were chosen to be simulated with the HCP prototype. The fission product release during normal operation conditions will be calculated with STACY based on a core status derived from SERPENT and MGT–3D. Comparisons will be shown against data generated by the legacy codes VSOP99/11, NAKURE and FRESCO-II. (author)

First results for fluid dynamics, neutronics and fission product behavior in HTR applying the HTR code package (HCP) prototype

Energy Technology Data Exchange (ETDEWEB)

Allelein, H.-J., E-mail: h.j.allelein@fz-juelich.de [Forschungszentrum Jülich, 52425 Jülich (Germany); Institute for Reactor Safety and Reactor Technology, RWTH Aachen University, 52064 Aachen (Germany); Kasselmann, S.; Xhonneux, A.; Tantillo, F.; Trabadela, A.; Lambertz, D. [Forschungszentrum Jülich, 52425 Jülich (Germany)

2016-09-15

To simulate the different aspects of High Temperature Reactor (HTR) cores, a variety of specialized computer codes have been developed at Forschungszentrum Jülich (IEK-6) and Aachen University (LRST) in the last decades. In order to preserve knowledge, to overcome present limitations and to make these codes applicable to modern computer clusters, these individual programs are being integrated into a consistent code package. The so-called HTR code package (HCP) couples the related and recently applied physics models in a highly integrated manner and therefore allows to simulate phenomena with higher precision in space and time while at the same time applying state-of-the-art programming techniques and standards. This paper provides an overview of the status of the HCP and reports about first benchmark results for an HCP prototype which couples the fluid dynamics and time dependent neutronics code MGT-3D, the burn up code TNT and the fission product release code STACY. Due to the coupling of MGT-3D and TNT, a first step towards a new reactor operation and accident simulation code was made, where nuclide concentrations calculated by TNT lead to new cross sections, which are fed back into MGT-3D. Selected operation scenarios of the HTR-Module 200 concept plant and the HTTR were chosen to be simulated with the HCP prototype. The fission product release during normal operation conditions will be calculated with STACY based on a core status derived from SERPENT and MGT-3D. Comparisons will be shown against data generated by SERPENT and the legacy codes VSOP99/11, NAKURE and FRESCO-II.

Chlamydia trachomatis responds to heat shock, penicillin induced persistence, and IFN-gamma persistence by altering levels of the extracytoplasmic stress response protease HtrA

Directory of Open Access Journals (Sweden)

Mathews Sarah A

2008-11-01

Full Text Available Abstract Background Chlamydia trachomatis, an obligate intracellular human pathogen, is the most prevalent bacterial sexually transmitted infection worldwide and a leading cause of preventable blindness. HtrA is a virulence and stress response periplasmic serine protease and molecular chaperone found in many bacteria. Recombinant purified C. trachomatis HtrA has been previously shown to have both activities. This investigation examined the physiological role of Chlamydia trachomatis HtrA. Results The Chlamydia trachomatis htrA gene complemented the lethal high temperature phenotype of Escherichia coli htrA- (>42°C. HtrA levels were detected to increase by western blot and immunofluorescence during Chlamydia heat shock experiments. Confocal laser scanning microscopy revealed a likely periplasmic localisation of HtrA. During penicillin induced persistence of Chlamydia trachomatis, HtrA levels (as a ratio of LPS were initially less than control acute cultures (20 h post infection but increased to more than acute cultures at 44 h post infection. This was unlike IFN-γ persistence where lower levels of HtrA were observed, suggesting Chlamydia trachomatis IFN-γ persistence does not involve a broad stress response. Conclusion The heterologous heat shock protection for Escherichia coli, and increased HtrA during cell wall disruption via penicillin and heat shock, indicates an important role for HtrA during high protein stress conditions for Chlamydia trachomatis.

The present state of the HTR concept based on experience gained from AVR and THTR

International Nuclear Information System (INIS)

Wachholz, W.

1989-01-01

During the past ten years the development of a specific HTR concept has made remarkable progress. This has been mainly characterized by making use of the safety characteristics typical of the High-Temperature Reactor (HTR). In the design, construction and operation of High-Temperature Reactors - especially AVR (15 MWe plant in Juelich, FRG) and THTR (300 MWe plant in Hamm-Uentrop, FRG) - comprehensive experience has been gained in the field of operational availability and safety, accident topology and plant risk of HTRs in recent years. This experience is relevant for the entire HTR line independent of specific projects. (author). 3 refs, 5 figs, 1 tab

The HTR modular power reactor system. Qualification of fuel elements and materials

International Nuclear Information System (INIS)

Heidenreich, U.; Breitling, H.; Nieder, R.; Ohly, W.; Mittenkuehler, A.; Ragoss, H.; Seehafer, H.J.; Wirtz, K.; Serafin, N.

1989-01-01

For further development of the HTR modular power reactor system (HTR-M-KW), the project activities for 'Qualification of fuel elements and materials' reported here cover the work for specifying the qualifications to be met by metallic and ceramic materials, taking into account the design-based requirements and the engineered safety requirements. The fission product retention data determined for the HTR modular reactor fuel elements could be better confirmed by evaluation of the experiments, and have been verified by various calculation methods for different operating conditions. The qualification of components was verified by strength analyses including a benchmark calculation for specified normal operation and emergencies; the results show a convenient behaviour of the components and their materials. In addition, a fuel element burnup measuring system was designed that applies Cs-137 gamma spectroscopy; its feasibility was checked by appropriate analyses, and qualification work is in progress. The installation of a prototype measurement system is the task for project No. 03 IAT 211. (orig.) [de

Simulation and study on reactivity disturbs dynamic character of HTR-10 nuclear power system

International Nuclear Information System (INIS)

Huang Xiaojin; Feng Yuankun

2002-01-01

In order to not only know 10 MW High Temperature Gas Cooled Reactor (HTR-10) nuclear power system's dynamic character more deeply but also to satisfy requirements of control system's design and analysis, the dynamic model of HTR-10 nuclear power system is established on the basis of dynamic model of HTR-10 nuclear system, which supplies turbine and generate electricity system model. Using this model, system's main variables' dynamic processes are simulated when control rod takes step reactivity disturb. The concussive progresses which is caused by reactivity disturb are analyzed. The results indicate that fuel temperature changing more slowly than nuclear power makes reactivity negative feedback not to restrain power changing, and then power concussive progress comes to being

Evaluation of the HTR-10 Reactor as a Benchmark for Physics Code QA

International Nuclear Information System (INIS)

William K. Terry; Soon Sam Kim; Leland M. Montierth; Joshua J. Cogliati; Abderrafi M. Ougouag

2006-01-01

The HTR-10 is a small (10 MWt) pebble-bed research reactor intended to develop pebble-bed reactor (PBR) technology in China. It will be used to test and develop fuel, verify PBR safety features, demonstrate combined electricity production and co-generation of heat, and provide experience in PBR design, operation, and construction. As the only currently operating PBR in the world, the HTR-10 can provide data of great interest to everyone involved in PBR technology. In particular, if it yields data of sufficient quality, it can be used as a benchmark for assessing the accuracy of computer codes proposed for use in PBR analysis. This paper summarizes the evaluation for the International Reactor Physics Experiment Evaluation Project (IRPhEP) of data obtained in measurements of the HTR-10's initial criticality experiment for use as benchmarks for reactor physics codes

The failure mechanisms of HTR coated particle fuel and computer code

International Nuclear Information System (INIS)

Yang Lin; Liu Bing; Shao Youlin; Liang Tongxiang; Tang Chunhe

2010-01-01

The basic constituent unit of fuel element in HTR is ceramic coated particle fuel. And the performance of coated particle fuel determines the safety of HTR. In addition to the traditional detection of radiation experiments, establishing computer code is of great significance to the research. This paper mainly introduces the structure and the failure mechanism of TRISO-coated particle fuel, as well as a few basic assumptions,principles and characteristics of some existed main overseas codes. Meanwhile, this paper has proposed direction of future research by comparing the advantages and disadvantages of several computer codes. (authors)

Analysis of the link between the redox state and enzymatic activity of the HtrA (DegP protein from Escherichia coli.

Directory of Open Access Journals (Sweden)

Tomasz Koper

Full Text Available Bacterial HtrAs are proteases engaged in extracytoplasmic activities during stressful conditions and pathogenesis. A model prokaryotic HtrA (HtrA/DegP from Escherichia coli requires activation to cleave its substrates efficiently. In the inactive state of the enzyme, one of the regulatory loops, termed LA, forms inhibitory contacts in the area of the active center. Reduction of the disulfide bond located in the middle of LA stimulates HtrA activity in vivo suggesting that this S-S bond may play a regulatory role, although the mechanism of this stimulation is not known. Here, we show that HtrA lacking an S-S bridge cleaved a model peptide substrate more efficiently and exhibited a higher affinity for a protein substrate. An LA loop lacking the disulfide was more exposed to the solvent; hence, at least some of the interactions involving this loop must have been disturbed. The protein without S-S bonds demonstrated lower thermal stability and was more easily converted to a dodecameric active oligomeric form. Thus, the lack of the disulfide within LA affected the stability and the overall structure of the HtrA molecule. In this study, we have also demonstrated that in vitro human thioredoxin 1 is able to reduce HtrA; thus, reduction of HtrA can be performed enzymatically.

Graphite Oxidation Simulation in HTR Accident Conditions

Energy Technology Data Exchange (ETDEWEB)

El-Genk, Mohamed

2012-10-19

Massive air and water ingress, following a pipe break or leak in steam-generator tubes, is a design-basis accident for high-temperature reactors (HTRs). Analysis of these accidents in both prismatic and pebble bed HTRs requires state-of-the-art capability for predictions of: 1) oxidation kinetics, 2) air helium gas mixture stratification and diffusion into the core following the depressurization, 3) transport of multi-species gas mixture, and 4) graphite corrosion. This project will develop a multi-dimensional, comprehensive oxidation kinetics model of graphite in HTRs, with diverse capabilities for handling different flow regimes. The chemical kinetics/multi-species transport model for graphite burning and oxidation will account for temperature-related changes in the properties of graphite, oxidants (O2, H2O, CO), reaction products (CO, CO2, H2, CH4) and other gases in the mixture (He and N2). The model will treat the oxidation and corrosion of graphite in geometries representative of HTR core component at temperatures of 900°C or higher. The developed chemical reaction kinetics model will be user-friendly for coupling to full core analysis codes such as MELCOR and RELAP, as well as computational fluid dynamics (CFD) codes such as CD-adapco. The research team will solve governing equations for the multi-dimensional flow and the chemical reactions and kinetics using Simulink, an extension of the MATLAB solver, and will validate and benchmark the model's predictions using reported experimental data. Researchers will develop an interface to couple the validated model to a commercially available CFD fluid flow and thermal-hydraulic model of the reactor , and will perform a simulation of a pipe break in a prismatic core HTR, with the potential for future application to a pebble-bed type HTR.

Proceedings of the Fifth Seminar of High Temperature Reactor: The Role and Challenge with HTR Opportunity in the Twenty-first Century

International Nuclear Information System (INIS)

As-Natio-Lasman; Zaki-Su'ud; Bambang-Sugiono

2000-11-01

The Seminar in HTR Reactor has become routine activities held in BATAN since 1994. This Seminar is a continuation of the Seminar on Technology and HTR Application held by Centre for Development of Advanced Reactor System. The theme of the seminar is Role, Challenge, Opportunity of HTR in the Twenty-first Century. Thirteen papers presented in the seminar were collected into proceedings. The aims of the proceedings is to provide information and references on nuclear technology, mainly on HTR technology. (DII)

The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line.

Science.gov (United States)

Bracha, Shay; Viall, Austin; Goodall, Cheri; Stang, Bernadette; Ruaux, Craig; Seguin, Bernard; Chappell, Patrick E

2013-12-12

The significance of the serotonergic system in bone physiology and, more specifically, the importance of the five hydroxytryptamine receptor 2A (5HTR2A) in normal osteoblast proliferation have been previously described; however the role of serotonin in osteosarcoma remains unclear. Particularly, the expression and function of 5HTR2A in canine osteosarcoma has not yet been studied, thus we sought to determine if this indoleamine modulates cellular proliferation in vitro. Using real time quantitative reverse transcription PCR and immunoblot analyses, we explored receptor expression and signaling differences between non-neoplastic canine osteoblasts (CnOb) and an osteosarcoma cell line (COS). To elucidate specific serotonergic signaling pathways triggered by 5HTR2A, we performed immunoblots for ERK and CREB. Finally, we compared cell viability and the induction of apoptosis in the presence 5HTR2A agonists and antagonists. 5HTR2A was overexpressed in the malignant cell line in comparison to normal cells. In CnOb cells, ERK phosphorylation (ERK-P) decreased in response to both serotonin and a specific 5HTR2A antagonist, ritanserin. In contrast, ERK-P abundance increased in COS cells following either treatment. While endogenous CREB was undetectable in CnOb, CREB was observed constitutively in COS, with expression and exhibited increased CREB phosphorylation following escalating concentrations of ritanserin. To determine the influence of 5HTR2A signaling on cell viability we challenged cells with ritanserin and serotonin. Our findings confirmed that serotonin treatment promoted cell viability in malignant cells but not in normal osteoblasts. Conversely, ritanserin reduced cell viability in both the normal and osteosarcoma cells. Further, ritanserin induced apoptosis in COS at the same concentrations associated with decreased cell viability. These findings confirm the existence of a functional 5HTR2A in a canine osteosarcoma cell line. Results indicate that intracellular

Plant Operation Station for HTR-PM Low Power and Shutdown operation Probabilistic safety analysis

International Nuclear Information System (INIS)

Liu Tao; Tong Jiejuan

2014-01-01

Full range Probabilistic safety analysis (PSA) is one of key conditions for nuclear power plant (NPP) licensing according to the requirement of nuclear safety regulatory authority. High Temperature Gas Cooled Reactor Pebble-bed Module (HTR-PM) has developed construction design and prepared for the charging license application. So after the normal power operation PSA submitted for review, the Low power and Shutdown operation Probabilistic safety analysis (LSPSA) also begin. The results of LSPSA will together with prior normal power PSA results to demonstrate the safety level of HTR-PM NPP Plant Operation Station (POS) is one of important terms in LSPSA. The definition of POS lays the foundation for LSPSA modeling. POS provides initial and boundary conditions for the following event tree and fault tree model development. The aim of this paper is to describe the state-of-the-art of POS definition for HTR-PM LSPSA. As for the first attempt to the high temperature gas cooled reactor module plant, the methodology and procedure of POS definition refers to the LWR LSPSA guidance, and adds to plant initial status analysis due to the HTR-PM characteristics. A specific set of POS grouping vectors is investigate and suggested for HTR-PM NPP, which reflects the characteristics of plant modularization and on-line refueling. As a result, seven POSs are given according to the grouping vectors at the end of the paper. They will be used to the LSPSA modelling and adjusted if necessary. The papers ’work may provide reference to the analogous NPP LSPSA. (author)

Neutron Fluence And DPA Rate Analysis In Pebble-Bed HTR Reactor Vessel Using MCNP

Science.gov (United States)

Hamzah, Amir; Suwoto; Rohanda, Anis; Adrial, Hery; Bakhri, Syaiful; Sunaryo, Geni Rina

2018-02-01

In the Pebble-bed HTR reactor, the distance between the core and the reactor vessel is very close and the media inside are carbon and He gas. Neutron moderation capability of graphite material is theoretically lower than that of water-moderated reactors. Thus, it is estimated much more the fast neutrons will reach the reactor vessel. The fast neutron collisions with the atoms in the reactor vessel will result in radiation damage and could be reducing the vessel life. The purpose of this study was to obtain the magnitude of neutron fluence in the Pebble-bed HTR reactor vessel. Neutron fluence calculations in the pebble-bed HTR reactor vessel were performed using the MCNP computer program. By determining the tally position, it can be calculated flux, spectrum and neutron fluence in the position of Pebble-bed HTR reactor vessel. The calculations results of total neutron flux and fast neutron flux in the reactor vessel of 1.82x108 n/cm2/s and 1.79x108 n/cm2/s respectively. The fast neutron fluence in the reactor vessel is 3.4x1017 n/cm2 for 60 years reactor operation. Radiation damage in stainless steel material caused by high-energy neutrons (> 1.0 MeV) will occur when it has reached the neutron flux level of 1.0x1024 n/cm2. The neutron fluence results show that there is no radiation damage in the Pebble-bed HTR reactor vessel, so it is predicted that it will be safe to operate at least for 60 years.

Strengths, weaknesses, opportunities and threats for HTR deployment in Europe

International Nuclear Information System (INIS)

Bredimas, Alexandre; Kugeler, Kurt; Fütterer, Michael A.

2014-01-01

High temperature nuclear reactors are a technology, of which early versions were demonstrated in the 1960s–1980s in Germany (AVR, THTR) and the United States (Peach Bottom, Fort St. Vrain). HTRs were initially designed for high temperature, high efficiency electricity generation but the technology, the market and the targeted applications have evolved since then to address industrial cogeneration and new operational conditions (in particular new safety regulations). This paper intends to analyse the latest status of HTR today, as regards their intrinsic strengths and weaknesses and their external context, whether positive (opportunities) or negative (threats). Different dimensions are covered by the analysis: technology status, results from R and D programmes (especially in Europe), competences and skills, licensing aspects, experience feedback from demonstrator operation (in particular in Germany), economic conditions and other non-technical aspects. Europe has a comprehensive experience in the field of HTR with capabilities in both pebble bed and prismatic designs (R and D, engineering, manufacturing, operation, dismantling, and the full fuel cycle). Europe is also a promising market for HTR as the process heat market is large with good industrial and cogeneration infrastructures. The analysis of the European situation is to a good deal indicative for the global potential of this technology

Viability of HTR-10 as a Primary Driver of an Energy Complex for Remote Settlement

International Nuclear Information System (INIS)

Choong, Philip T.

2014-01-01

HTR-10, a proven 10 MWt prototype pebble bed reactor, is capable of generating 4 MWe to the power grid. However; with evolutional power upgrades, its output performance can be substantially enhanced to drive an energy complex to co-generate electricity, hydrogen, desalinated water and process heat for a remote island or settlement of several thousand people. Unlike the much publicized SMR power concepts in the literature, HTR-10 is the only full-blown stand-alone power system that has been demonstrated to be inherently safe and capable of high temperature output. Furthermore, this particular HTR family of reactors is proliferation-resistant and possesses many desirable market-competitive advantages such as high thermal efficiency, low thermal pollution, zero carbon footprints and minimal exclusion zones. An innovative classroom project course is structured to stimulate science and engineering students to explore novel use of HTR-10 as a high temperature heat source to be the core of an intelligent zero emission energy (Smart-ZEE) module capable of providing all energy needs of a remote community or island. (author)

On the correctness of the thermoluminescent high-temperature ratio (HTR) method for estimating ionization density effects in mixed radiation fields

International Nuclear Information System (INIS)

Bilski, Pawel

2010-01-01

The high-temperature ratio (HTR) method which exploits changes in the LiF:Mg,Ti glow-curve due to high-LET radiation, has been used for several years to estimate LET in an unknown radiation field. As TL efficiency is known to decrease after doses of densely ionizing radiation, a LET estimate is used to correct the TLD-measured values of dose. The HTR method is purely empirical and its general correctness is questionable. The validity of the HTR method was investigated by theoretical simulation of various mixed radiation fields. The LET eff values estimated with the HTR method for mixed radiation fields were found in general to be incorrect, in some cases underestimating the true values of dose-averaged LET by an order of magnitude. The method produced correct estimates of average LET only in cases of almost mono-energetic fields (i.e. in non-mixed radiation conditions). The value of LET eff found by the HTR method may therefore be treated as a qualitative indicator of increased LET, but not as a quantitative estimator of average LET. However, HTR-based correction of the TLD-measured dose value (HTR-B method) was found to be quite reliable. In all cases studied, application of this technique improved the result. Most of the measured doses fell within 10% of the true values. A further empirical improvement to the method is proposed. One may therefore recommend the HTR-B method to correct for decreased TL efficiency in mixed high-LET fields.

Oxidation of carbon based material for innovative energy systems (HTR, fusion reactor): status and further needs

International Nuclear Information System (INIS)

Moormann, R.; Hinssen, H.K.; Latge, Ch.; Dumesnil, J.; Veltkamp, A.C.; Grabon, V.; Beech, D.; Buckthorpe, D.; Dominguez, T.; Krussenberg, A.K.; Wu, C.H.

2000-01-01

Following an overview on kinetics of carbon/gas reactions, status and further needs in selected safety relevant fields of graphite oxidation in high temperature reactors (HTRs) and fusion reactors are outlined. Kinetics was detected due to the presence of such elements as severe air ingress, lack of experimental data on Boudouard reaction and a similar lack of data in the field of advanced oxidation. The development of coatings which protect against oxidation should focus on stability under neutron irradiation and on the general feasibility of coatings on HTR pebble fuel graphite. Oxidation under normal operation of direct cycle HTR requires examinations of gas atmospheres and of catalytic effects. Advanced carbon materials like CFCs and mixed materials should be developed and tested with respect to their oxidation resistance in a common HTR/fusion task. In an interim HTR, fuel storage radiolytic oxidation under normal operation and thermal oxidation in accidents have to be considered. Plans for future work in these fields are described. (authors)

European energy policy and the potential impact of HTR and nuclear cogeneration

International Nuclear Information System (INIS)

Fütterer, Michael A.; Carlsson, Johan; Groot, Sander de; Deffrennes, Marc; Bredimas, Alexandre

2014-01-01

This paper first provides an update on the current state of play and the potential future role of nuclear energy in Europe. It then describes the EU energy policy tools in the area of nuclear technology. It explains the three-tier strategy of the European nuclear technology platform and its demonstration initiatives, here specifically for nuclear cogeneration and HTR. The paper closes with an outlook on the boundary conditions at which HTR can become attractive for nuclear cogeneration, not only from an energy policy viewpoint but also economically

European energy policy and the potential impact of HTR and nuclear cogeneration

Energy Technology Data Exchange (ETDEWEB)

Fütterer, Michael A., E-mail: michael.fuetterer@ec.europa.eu [European Commission, Joint Research Centre, Institute for Energy and Transport, P.O. Box 2, NL-1755ZG Petten (Netherlands); Carlsson, Johan [European Commission, Joint Research Centre, Institute for Energy and Transport, P.O. Box 2, NL-1755ZG Petten (Netherlands); Groot, Sander de [Nuclear Research and consultancy Group, NL-1755ZG Petten (Netherlands); Deffrennes, Marc [European Commission, DG ENER, L-2530 Luxembourg (Luxembourg); Bredimas, Alexandre [LGI Consulting, 13 rue Marivaux, F-75002 Paris (France)

2014-05-01

This paper first provides an update on the current state of play and the potential future role of nuclear energy in Europe. It then describes the EU energy policy tools in the area of nuclear technology. It explains the three-tier strategy of the European nuclear technology platform and its demonstration initiatives, here specifically for nuclear cogeneration and HTR. The paper closes with an outlook on the boundary conditions at which HTR can become attractive for nuclear cogeneration, not only from an energy policy viewpoint but also economically.

Robot calibration with a photogrammetric on-line system using reseau scanning cameras

Science.gov (United States)

Diewald, Bernd; Godding, Robert; Henrich, Andreas

1994-03-01

The possibility for testing and calibration of industrial robots becomes more and more important for manufacturers and users of such systems. Exacting applications in connection with the off-line programming techniques or the use of robots as measuring machines are impossible without a preceding robot calibration. At the LPA an efficient calibration technique has been developed. Instead of modeling the kinematic behavior of a robot, the new method describes the pose deviations within a user-defined section of the robot's working space. High- precision determination of 3D coordinates of defined path positions is necessary for calibration and can be done by digital photogrammetric systems. For the calibration of a robot at the LPA a digital photogrammetric system with three Rollei Reseau Scanning Cameras was used. This system allows an automatic measurement of a large number of robot poses with high accuracy.

Procedures and results of the probabilistic safety study of the HTR-1160 plant

International Nuclear Information System (INIS)

Kroeger, W.; Bongartz, R.

1981-01-01

A research team of the Institute for Nuclear Safety Research of the Juelich Nuclear Research Center (KFA) and staff members of the Gesellschaft fuer Reaktorsicherheit, sponsored by the Federal Ministry of the Interior, carried out a safety and risk analysis of high temperature reactors. The studies, which included the transfer to German conditions and the modification in some points of methodology of the American AIPA Study, were performed on the German concept of an 1160 MWe HTR with block-type fuel elements. They referred to accidents and possible impacts on the environment, residual risks and measures to reduce them. The study covered a total of approx. 15 groups of initiating events, including potential external impacts. The dominating initiating events are transients in a pressurized reactor. Differences relative to the light water reactor concept arise with respect to releases as a result of accidents and, above all, release times; they are due to different physical characteristics. HTR'S are characterized by thermal inertia and resistance to temperatures. If the results of the study are extended to the HTR line with a pebble bed core currently in the planning phase, the power densities alone, which are considerably lower in some designs, are indicative of an even more effective fission product retention than is already found in the HTR-1160 plant analyzed here. (orig.) [de

Research on Fault Diagnosis of HTR-PM Based on Multilevel Flow Model

International Nuclear Information System (INIS)

Zhang Yong; Zhou Yangping

2014-01-01

In this paper, we focus on the application of Multilevel Flow Model (MFM) in the automatic real-time fault diagnosis of High Temperature Gas-cooled Reactor Pebble-bed Module (HTR-PM) accidents. In the MFM, the plant process is described abstractly in function level by mass, energy and information flows, which reveal the interaction between different components and capacitate the causal reasoning between functions according to the flow properties. Thus, in the abnormal status, a goal-function-component oriented fault diagnosis can be performed with the model at a very quick speed and abnormal alarms can be also precisely explained by the reasoning relationship of the model. By using MFM, a fault diagnosis model of HTR-PM plant is built, and the detailed process of fault diagnosis is also shown by the flowcharts. Due to lack of simulation data about HTR-PM, experiments are not conducted to evaluate the fault diagnosis performance, but analysis of algorithm feasibility and complexity shows that the diagnosis system will have a good ability to detect and diagnosis accidents timely. (author)

Plutonium re-cycle in HTR

Energy Technology Data Exchange (ETDEWEB)

Desoisa, J. A.

1974-03-15

The study of plutonium cycles in HTRs using reprocessed plutonium from Magnox and AGR fuel cycles has shown that full core plutonium/uranium loadings are in general not feasible, burn-up is limited due the need for lower loadings of plutonium to meet reload core reactivity limits, on-line refueling is not practicable due to the need for higher burnable poison loadings, and low conversion rates in the plutonium-uranium cycles cannot be mitigated by axial loading schemes so that fissile make-up is needed if HTR plutonium recycle is desired.

Prospective studies of HTR fuel cycles involving plutonium

International Nuclear Information System (INIS)

Bonin, B.; Greneche, D.; Carre, F.; Damian, F.; Doriath, J.Y.

2002-01-01

High Temperature Gas Cooled reactors (HTRs) are able to accommodate a wide variety of mixtures of fissile and fertile materials without any significant modification of the core design. This flexibility is due to an uncoupling between the parameters of cooling geometry, and the parameters which characterize neutronic optimisation (moderation ratio or heavy nuclide concentration and distribution). Among other advantageous features, an HTR core has a better neutron economy than a LWR because there is much less parasitic capture in the moderator (capture cross section of graphite is 100 times less than the one of water) and in internal structures. Moreover, thanks to the high resistance of the coated particles, HTR fuels are able to reach very high burn-ups, far beyond the possibilities offered by other fuels (except the special case of molten salt reactors). These features make HTRs especially interesting for closing the nuclear fuel cycle and stabilizing the plutonium inventory. A large number of fuel cycle studies are already available today, on 3 main categories of fuel cycles involving HTRs : i) High enriched uranium cycle, based on thorium utilization as a fertile material and HEU as a fissile material; ii) Low enriched uranium cycle, where only LEU is used (from 5% to 12%); iii) Plutonium cycle based on the utilization of plutonium only as a fissile material, with (or without) fertile materials. Plutonium consumption at high burnups in HTRs has already been tested with encouraging results under the DRAGON project and at Peach Bottom. To maximize plutonium consumption, recent core studies have also been performed on plutonium HTR cores, with special emphasis on weapon-grade plutonium consumption. In the following, we complete the picture by a core study for a HTR burning reactor-grade plutonium. Limits in burnup due to core neutronics are investigated for this type of fuel. With these limits in mind, we study in some detail the Pu cycle in the special case of a

Behavior of the P1.HTR mastocytoma cell line implanted in the chorioallantoic membrane of chick embryos

Directory of Open Access Journals (Sweden)

S.F. Avram

2013-01-01

Full Text Available The P1.HTR cell line includes highly transfectable cells derived from P815 mastocytoma cells originating from mouse breast tissue. Despite its widespread use in immunogenic studies, no data are available about the behavior of P1.HTR cells in the chick embryo chorioallantoic membrane model. The objective of the present investigation was to study the effects of P1.HTR cells implanted on the chorioallantoic membrane of chick embryos. We inoculated P1.HTR cells into the previously prepared chick embryo chorioallantoic membrane and observed the early and late effects of these cells by stereomicroscopy, histochemistry and immunohistochemistry. A highly angiotropic and angiogenic effect occurred early after inoculation and a tumorigenic potential with the development of mastocytoma keeping well mast cells immunophenotype was detected later during the development. The P1.HTR mastocytoma cell line is a good tool for the development of the chick embryo chorioallantoic membrane mastocytoma model and also for other studies concerning the involvement of blood vessels. The chick embryo chorioallantoic membrane model of mastocytoma retains the mast cell immunophenotype under experimental conditions and could be used as an experimental tool for in vivo preliminary testing of antitumor and antivascular drugs.

The effects of applying silicon carbide coating on core reactivity of pebble-bed HTR in water ingress accident

Energy Technology Data Exchange (ETDEWEB)

Zuhair, S.; Setiadipura, Topan [National Nuclear Energy Agency of Indonesia, Serpong Tagerang Selatan (Indonesia). Center for Nuclear Reactor Technology and Safety; Su' ud, Zaki [Bandung Institute of Technology (Indonesia). Dept. of Physics

2017-03-15

Graphite is used as the moderator, fuel barrier material, and core structure in High Temperature Reactors (HTRs). However, despite its good thermal and mechanical properties below the radiation and high temperatures, it cannot avoid corrosion as a consequence of an accident of water/air ingress. Degradation of graphite as a main HTR material and the formation of dangerous CO gas is a serious problem in HTR safety. One of the several steps that can be adopted to avoid or prevent the corrosion of graphite by the water/air ingress is the application of a thin layer of silicon carbide (SiC) on the surface of the fuel element. This study investigates the effect of applying SiC coating on the fuel surfaces of pebble-bed HTR in water ingress accident from the reactivity points of view. A series of reactivity calculations were done with the Monte Carlo transport code MCNPX and continuous energy nuclear data library ENDF/B-VII at temperature of 1200 K. Three options of UO{sub 2}, PuO{sub 2}, and ThO{sub 2}/UO{sub 2} fuel kernel were considered to obtain the inter comparison of the core reactivity of pebble-bed HTR in conditions of water/air ingress accident. The calculation results indicated that the UO{sub 2}-fueled pebble-bed HTR reactivity was slightly reduced and relatively more decreased when the thickness of the SiC coating increased. The reactivity characteristic of ThO{sub 2}/UO{sub 2}-fueled pebble-bed HTR showed a similar trend to that of UO{sub 2}, but did not show reactivity peak caused by water ingress. In contrast with UO{sub 2}- and ThO{sub 2}-fueled pebble-bed HTR, although the reactivity of PuO{sub 2}-fueled pebble-bed HTR was the lowest, its characteristics showed a very high reactivity peak (0.33 Δk/k) and this introduction of positive reactivity is difficult to control. SiC coating on the surface of the plutonium fuel pebble has no significant impact. From the comparison between reactivity characteristics of uranium, thorium and plutonium cores with 0

A PC-based high temperature gas reactor simulator for Indonesian conceptual HTR reactor basic training

Science.gov (United States)

Syarip; Po, L. C. C.

2018-05-01

In planning for nuclear power plant construction in Indonesia, helium cooled high temperature reactor (HTR) is favorable for not relying upon water supply that might be interrupted by earthquake. In order to train its personnel, BATAN has cooperated with Micro-Simulation Technology of USA to develop a 200 MWt PC-based simulation model PCTRAN/HTR. It operates in Win10 environment with graphic user interface (GUI). Normal operation of startup, power maneuvering, shutdown and accidents including pipe breaks and complete loss of AC power have been conducted. A sample case of safety analysis simulation to demonstrate the inherent safety features of HTR was done for helium pipe break malfunction scenario. The analysis was done for the variation of primary coolant pipe break i.e. from 0,1% - 0,5 % and 1% - 10 % helium gas leakages, while the reactor was operated at the maximum constant power of 10 MWt. The result shows that the highest temperature of HTR fuel centerline and coolant were 1150 °C and 1296 °C respectively. With 10 kg/s of helium flow in the reactor core, the thermal power will back to the startup position after 1287 s of helium pipe break malfunction.

Operational requirements of spherical HTR fuel elements and their performance

International Nuclear Information System (INIS)

Roellig, K.; Theymann, W.

1985-01-01

The German development of spherical fuel elements with coated fuel particles led to a product design which fulfils the operational requirements for all HTR applications with mean gas exit temperatures from 700 deg C (electricity and steam generation) up to 950 deg C (supply of nuclear process heat). In spite of this relatively wide span for a parameter with strong impact on fuel element behaviour, almost identical fuel specifications can be used for the different reactor purposes. For pebble bed reactors with relatively low gas exit temperatures of 700 deg C, the ample design margins of the fuel elements offer the possibility to enlarge the scope of their in-service duties and, simultaneously, to improve fuel cycle economics. This is demonstrated for the HTR-500, an electricity and steam generating 500 MWel eq plant presently proposed as follow-up project to the THTR-300. Due to the low operating temperatures of the HTR-500 core, the fuel can be concentrated in about 70% of the pebbles of the core thus saving fuel cycle costs. Under all design accident conditions fuel temperatures are maintained below 1250 deg C. This allows a significant reduction in the engineered activity barriers outside the primary circuit, in particular for the loss of coolant accident. Furthermore, access to major primary circuit components and the reuse of the fuel elements after any design accident are possible. (author)

Calculation of the Fission Product Release for the HTR-10 based on its Operation History

International Nuclear Information System (INIS)

Xhonneux, A.; Druska, C.; Struth, S.; Allelein, H.-J.

2014-01-01

Since the first criticality of the HTR-10 test reactor in 2000, a rather complex operation history was performed. As the HTR-10 is the only pebble bed reactor in operation today delivering experimental data for HTR simulation codes, an attempt was made to simulate the whole reactor operation up to the presence. Special emphasis was put on the fission product release behaviour as it is an important safety aspect of such a reactor. The operation history has to be simulated with respect to the neutronics, fluid mechanics and depletion to get a detailed knowledge about the time-dependent nuclide inventory. In this paper we report about such a simulation with VSOP 99/11 and our new fission product release code STACY. While STACY (Source Term Analysis Code System) so far was able to calculate the fission product release rates in case of an equilibrium core and during transients, it now can also be applied to running-in-phases. This coupling demonstrates a first step towards an HCP Prototype. Based on the published power histogram of the HTR-10 and additional information about the fuel loading and shuffling, a coupled neutronics, fluid dynamics and depletion calculation was performed. Special emphasis was put on the complex fuel-shuffling scheme within both VSOP and STACY. The simulations have shown that the HTR-10 up to now generated about 2580 MWd while reshuffling the core about 2.3 times. Within this paper, STACY results for the equilibrium core will be compared with FRESCO-II results being published by INET. Compared to these release rates, which are based on a few user defined life histories, in this new approach the fission product release rates of Ag-110m, Cs-137, Sr-90 and I-131 have been simulated for about 4000 tracer pebbles with STACY. For the calculation of the HTR-10 operation history time-dependent release rates are being presented as well. (author)

Concept of a HTR modular plant for generation of process heat in a chemical plant

International Nuclear Information System (INIS)

1991-07-01

This final report summarizes the results of a preliminary study on behalf of Buna AG and Leunawerke AG. With regard to the individual situations the study investigated the conditions for modular HTR-2 reactors to cover on-site process heat and electric power demands. HTR-2 reactor erection and operation were analyzed for their economic efficiency compared with fossil-fuel power plants. Considering the prospective product lines, the technical and economic conditions were developed in close cooperation with Buna AG and Leunawerke AG. The study focused on the technical integration of modular HTR reactors into plants with regard to safety concepts, on planning, acceptance and erection concepts which largely exclude uncalculable scheduling and financial risks, and on comparative economic analyses with regard to fossil-fuel power plants. (orig.) [de

Experimental Study of Fuel Element Motion in HTR-PM Conveying Pipelines

International Nuclear Information System (INIS)

Wang Xin; Zhang Haiquan; Nie Junfeng; Li Hongke; Liu Jiguo; He Ayada

2014-01-01

The motion action of sphere fuel element (FE) inside fuel pipelines in HTR-PM is indeterminate. Fuel motion is closely connected with the interaction of FE and inner surface of fuel conveying pipe. In this paper, motion method of fuel elements in its conveying pipe is Experimental studied. Combined with the measurement of the fuel passing speed in stainless steel pipe and the track left by sphere ball for experiment, interaction modes of fuel and inner-surface of pipe, which is sliding friction, rolling friction and Collision, has been found. The modes of interaction can affect the speed of fuel conveying, amount of sphere waste and operation stability of fuel handling of high temperature reactor-pebble bed modules (HTR-PM). Furthermore, the motion process of fuel passing a big-elbow which is lying on the top of fuel pneumatic hoisting pipe were experimented. The result shows that the speed before and the speed after the elbow is positive correlation. But with the increase of speed before the elbow, the speed after the elbow increase less. Meanwhile the fuel conveying mode changes from friction to collision. And the conveying process is still steady. The effect can be used to controlling the speed of fuel conveying in fuel handling process of HTR-PM. (author)

Study on the Break Accidents of the HTR-PM Primary Loop

International Nuclear Information System (INIS)

Lang Minggang; Sun Ximing; Zheng Yanhua

2014-01-01

In thermal hydraulics design and safety analysis of the HTR-PM, the THERMIX code was used to study the behavior of the helium in the primary system. Once the helium leaks from the primary loop through a break or a relief valve, it is hard to simulate the states of the leakage room with THERMIX. In this paper, the latest version of RELAP5/MOD4, was used to simulate the behavior of the helium released to the containment rooms. A RELAP5/MOD4 model of the HTR-PM, including the core, the primary system, the secondary loop and the containment, were developed and evaluated in this paper. Based on the model, this paper studied the accidents consequences of a large break in the pressure relief room and a small break in the instrument room of the HTR-PM reactor building. The simulating results illustrate that the temperature in the pressure relief room was no more than 200℃ after a un-isolating large break, and the temperature in the instrument room is less than 130 ℃ after a small un-isolating break. The analysis shows that the scram function and the ability to monitor the reactor temperature and pressure after accidents would not be affected by the break. (author)

Predictions of the Bypass Flows in the HTR-PM Reactor Core

International Nuclear Information System (INIS)

Sun Jun; Chen Zhipeng; Zheng Yanhua; Shi Lei; Li Fu

2014-01-01

In the HTR-PM reactor core, the basic structure materials are large amount of graphite reflectors and carbon bricks. Small gaps among those graphite and carbon bricks are widespread in the reactor core so that the cold helium flow may be bypassed and not completely heated. The bypass flows in relative lower temperature would change the flow and temperature distributions in the reactor core, therefore, the accurate prediction of bypass flows need to be carried out carefully to evaluate the influence to the reactor safety. Based on the characteristics of the bypass flow problem, hybrid method of the flow network and the CFD tools was employed to represent the connections and calculate flow distributions of all the main flow and bypass flow paths. In this paper, the hybrid method was described and applied to specific bypass flow problem in the HTR-PM. Various bypass flow paths in the HTR-PM were reviewed, figured out, and modeled by the flow network and the CFD methods, including the axial vertical gaps in the side reflectors, control rod channels, absorber sphere channels and radial gap flow through keys around the hot helium plenum. The bypass flow distributions and its flow rate ratio to the total flow rate in the primary loop were also calculated, discussed and evaluated. (author)

Prediction of extracellular proteases of the human pathogen Helicobacter pylori reveals proteolytic activity of the Hp1018/19 protein HtrA.

Directory of Open Access Journals (Sweden)

Martin Löwer

Full Text Available Exported proteases of Helicobacter pylori (H. pylori are potentially involved in pathogen-associated disorders leading to gastric inflammation and neoplasia. By comprehensive sequence screening of the H. pylori proteome for predicted secreted proteases, we retrieved several candidate genes. We detected caseinolytic activities of several such proteases, which are released independently from the H. pylori type IV secretion system encoded by the cag pathogenicity island (cagPAI. Among these, we found the predicted serine protease HtrA (Hp1019, which was previously identified in the bacterial secretome of H. pylori. Importantly, we further found that the H. pylori genes hp1018 and hp1019 represent a single gene likely coding for an exported protein. Here, we directly verified proteolytic activity of HtrA in vitro and identified the HtrA protease in zymograms by mass spectrometry. Overexpressed and purified HtrA exhibited pronounced proteolytic activity, which is inactivated after mutation of Ser205 to alanine in the predicted active center of HtrA. These data demonstrate that H. pylori secretes HtrA as an active protease, which might represent a novel candidate target for therapeutic intervention strategies.

The conceptual flowsheet of effluent treatment during preparing spherical fuel elements of HTR

Energy Technology Data Exchange (ETDEWEB)

Ying, Quan, E-mail: quanying@tsinghua.edu.cn; Xiao-tong, Chen; Bing, Liu; Gen-na, Fu; Yang, Wang; You-lin, Shao; Zhen-ming, Lu; Ya-ping, Tang; Chun-he, Tang

2014-05-01

High temperature gas-cooled reactor (HTR) is one of the advanced nuclear reactors owing to its inherent safety and broad applications. For HTR, one of the key components is the ceramic fuel element. During the preparation of spherical fuel elements, the radioactive effluent treatment is necessary. Referring to the current treatment technologies and methods, the conceptual flowsheet of low-level radioactive effluent treatment during preparing spherical fuel elements was established. According to the above treatment process, the uranium concentration was decreased from 200 mg/l to the level of discharged standard.

Profiles of facilities used for HTR research and testing

International Nuclear Information System (INIS)

1980-05-01

This report contains a current description of facilities supporting HTR research and development submitted by countries participating in the IWGFR. It has the purpose of providing an overview of the facilities available for use and of the types of experiments that can be conducted therein

Would HTR be suitable for application in the Netherlands?

International Nuclear Information System (INIS)

Heek, A.I. van.

1994-08-01

The modular HTR may be a reactor type, which would have sufficient societal support to be constructed in the Netherlands. The economic approach would be fundamentally different from that applied in present nuclear technology. In a national research program this is being investigated. (orig.)

Numerical analysis of magnetically suspended rotor in HTR-10 helium circulator being dropped into auxiliary bearings

International Nuclear Information System (INIS)

Zhao Jingxiong; Yang Guojun; Li Yue; Yu Suyuan

2012-01-01

Active magnetic bearings (AMB) have been selected to support the rotor of primary helium circulator in commercial 10 Mega-Walt High Temperature Gas-cooled Reactor (HTR-10). In an AMB system, the auxiliary bearings are necessary to protect the AMB components in case of losing power. This paper performs the impact simulation of Magnetically Suspended Rotor in HTR-10 Helium Circulator being dropped into the auxiliary bearings using the finite element program ABAQUS. The dynamic response and the strain field of auxiliary bearings are analyzed. The results achieved by the numerical analysis are in agreement with the experiment results. Therefore, the feasibility of the design of auxiliary bearing and the possibility of using the AMB system in the HTR are proved. (authors)

Pilot study of dynamic Bayesian networks approach for fault diagnostics and accident progression prediction in HTR-PM

Energy Technology Data Exchange (ETDEWEB)

Zhao, Yunfei; Tong, Jiejuan; Zhang, Liguo, E-mail: lgzhang@tsinghua.edu.cn; Zhang, Qin

2015-09-15

Highlights: • Dynamic Bayesian network is used to diagnose and predict accident progress in HTR-PM. • Dynamic Bayesian network model of HTR-PM is built based on detailed system analysis. • LOCA Simulations validate the above model even if part monitors are lost or false. - Abstract: The first high-temperature-reactor pebble-bed demonstration module (HTR-PM) is under construction currently in China. At the same time, development of a system that is used to support nuclear emergency response is in progress. The supporting system is expected to complete two tasks. The first one is diagnostics of the fault in the reactor based on abnormal sensor measurements obtained. The second one is prognostic of the accident progression based on sensor measurements obtained and operator actions. Both tasks will provide valuable guidance for emergency staff to take appropriate protective actions. Traditional method for the two tasks relies heavily on expert judgment, and has been proven to be inappropriate in some cases, such as Three Mile Island accident. To better perform the two tasks, dynamic Bayesian networks (DBN) is introduced in this paper and a pilot study based on the approach is carried out. DBN is advantageous in representing complex dynamic systems and taking full consideration of evidences obtained to perform diagnostics and prognostics. Pearl's loopy belief propagation (LBP) algorithm is recommended for diagnostics and prognostics in DBN. The DBN model of HTR-PM is created based on detailed system analysis and accident progression analysis. A small break loss of coolant accident (SBLOCA) is selected to illustrate the application of the DBN model of HTR-PM in fault diagnostics (FD) and accident progression prognostics (APP). Several advantages of DBN approach compared with other techniques are discussed. The pilot study lays the foundation for developing the nuclear emergency response supporting system (NERSS) for HTR-PM.

Process heat applications of HTR-PM600 in Chinese petrochemical industry: Preliminary study of adaptability and economy

International Nuclear Information System (INIS)

Fang, Chao; Min, Qi; Yang, Yanran; Sun, Yuliang

2017-01-01

Highlights: •High Temperature Gas Cooled Reactor (HTGR) could work as heat source for petrochemical industry. •The joint of a 600 MW modular HTGR (HTR-PM600) and petrochemical industry is achievable. •The mature technology of turbine in thermal power station could be readily adopted. •The economy of this scheme is also acceptable. -- Abstract: High Temperature Gas Cooled Reactor (HTGR) could work as heat source for petrochemical industry. In this article, the preliminary feasibility of a 600 MW modular HTGR (HTR-PM600) working as heat source for a typical hypothetical Chinese petrochemical factory is discussed and it is found that the joint of HTR-PM600 and petrochemical industry is achievable. In detail, the heat and water balance analysis of the petrochemical factory is given. Furthermore, the direct cost of heat supplied by HTR-PM600 is calculated and corresponding economy is estimated. The results show that though there are several challenges, the application of process heat of HTGR to petrochemical industry is practical in sense of both technology and economy.

Long-term testing of HTR fuel elements in the Federal Republic of Germany

International Nuclear Information System (INIS)

Nickel, H.

1986-12-01

The extensive results from irradiation experiments carried out on coated particles, on graphitic matrices of different composition and on integral fuel elements have shown that the spherical fuel elements with high-enriched uranium/thorium mixed-oxide particles and optimized graphitic matrix are available for use in the planned HTR facilities. A concentrated qualification programme is on the way in order to bring the fuel elements with particles from low-enriched uranium dioxide (LEU) and TRISO coating to a comparable level of experience and knowledge, i.e. to make them licensable for the planned HTR facilities. (orig.) [de

Maw and spent HTR Fuel Element Test storage in Boreholes in rock salt

International Nuclear Information System (INIS)

Barnert, E.; Brucher, P.H.; Kroth, K.; Merz, E.; Niephaus, D.

1986-01-01

The Budesminister fur Forschung und Technolgie (BMFT, Federal Ministry for Research and Technology) is sponsoring a project at the Kernforschungsanlage Julich (KFA, Juelich Nuclear Research Centre) entitled ''MAW and HTR Fuel Element Test disposal in Boreholes.'' The aim of this project is to develop a technique for the final disposal of (1) dissolver sludge, (2) cladding hulls/structural components and (3) spent HTR fuels elements in salt, and to test this technique in the abandoned Asse salt mine, including safety calculations and safety engineering demonstrations. The project is divided into the sub-projects I ''Disposal/sealing technique'' and II ''Retrievable disposal test.''

7th International Topical Meeting on High Temperature Reactor Technology: The modular HTR is advancing towards reality. Papers and Presentations

International Nuclear Information System (INIS)

2014-01-01

HTR2014 aimed at providing an international platform for researchers, engineers and industrial professionals to share their innovative ideas, valuable experience and recent progresses on high temperature gas-cooled reactor (HTR) and its application technologies.

High Temperature Reactor (HTR) Deep Burn Core and Fuel Analysis: Design Selection for the Prismatic Block Reactor With Results from FY-2011 Activities

Energy Technology Data Exchange (ETDEWEB)

Michael A. Pope

2011-10-01

The Deep Burn (DB) Project is a U.S. Department of Energy sponsored feasibility study of Transuranic Management using high burnup fuel in the high temperature helium cooled reactor (HTR). The DB Project consists of seven tasks: project management, core and fuel analysis, spent fuel management, fuel cycle integration, TRU fuel modeling, TRU fuel qualification, and HTR fuel recycle. In the Phase II of the Project, we conducted nuclear analysis of TRU destruction/utilization in the HTR prismatic block design (Task 2.1), deep burn fuel/TRISO microanalysis (Task 2.3), and synergy with fast reactors (Task 4.2). The Task 2.1 covers the core physics design, thermo-hydraulic CFD analysis, and the thermofluid and safety analysis (low pressure conduction cooling, LPCC) of the HTR prismatic block design. The Task 2.3 covers the analysis of the structural behavior of TRISO fuel containing TRU at very high burnup level, i.e. exceeding 50% of FIMA. The Task 4.2 includes the self-cleaning HTR based on recycle of HTR-generated TRU in the same HTR. Chapter IV contains the design and analysis results of the 600MWth DB-HTR core physics with the cycle length, the average discharged burnup, heavy metal and plutonium consumptions, radial and axial power distributions, temperature reactivity coefficients. Also, it contains the analysis results of the 450MWth DB-HTR core physics and the analysis of the decay heat of a TRU loaded DB-HTR core. The evaluation of the hot spot fuel temperature of the fuel block in the DB-HTR (Deep-Burn High Temperature Reactor) core under full operating power conditions are described in Chapter V. The investigated designs are the 600MWth and 460MWth DB-HTRs. In Chapter VI, the thermo-fluid and safety of the 600MWth DB-HTRs has been analyzed to investigate a thermal-fluid design performance at the steady state and a passive safety performance during an LPCC event. Chapter VII describes the analysis results of the TRISO fuel microanalysis of the 600MWth and 450

LEU-HTR critical experiment program for the PROTEUS facility in Switzerland

International Nuclear Information System (INIS)

Brogli, R.; Bucher, K.H.; Chawla, R.; Foskolos, K.; Luchsinger, H.; Mathews, D.; Sarlos, G.; Seiler, R.

1990-01-01

New critical experiments in the framework of an IAEA Coordinated Research Program on 'Validation of Safety Related Reactor Physics Calculations for Low Enriched HTRs' are planned at the PSI PROTEUS facility. The experiments are designed to supplement the experimental data base and reduce the design and licensing uncertainties for small- and medium-sized helium-cooled reactors using low-enriched uranium (LEU) and graphite high temperature fuel. The main objectives of the new experiments are to provide first-of-a-kind high quality experimental data on: 1) The criticality of simple, easy to interpret, single core region LEU HTR systems for several moderator-to-fuel ratios and several lattice geometries; 2) the changes in reactivity, neutron balance components and control rod effectiveness caused by water ingress into this type of reactor, and 3) the effects of the boron and/or hafnium absorbers that are used to modify the reactivity and the power distributions in typical HTR systems. Work on the design and licensing of the modified PROTEUS critical facility is now in progress with the HTR experiments scheduled to begin early in 1991. Several international partners will be involved in the planning, execution and analysis of these experiments in order to insure that they are relevant and cost effective with respect to the various gas cooled reactor national programs. (author)

LEU-HTR critical experiment program for the PROTEUS facility in Switzerland

Energy Technology Data Exchange (ETDEWEB)

Brogli, R; Bucher, K H; Chawla, R; Foskolos, K; Luchsinger, H; Mathews, D; Sarlos, G; Seiler, R [Paul Scherrer Institute, Laboratory for Reactor Physics and System Technology Wuerenlingen and Villigen, Villigen PSI (Switzerland)

1990-07-01

New critical experiments in the framework of an IAEA Coordinated Research Program on 'Validation of Safety Related Reactor Physics Calculations for Low Enriched HTRs' are planned at the PSI PROTEUS facility. The experiments are designed to supplement the experimental data base and reduce the design and licensing uncertainties for small- and medium-sized helium-cooled reactors using low-enriched uranium (LEU) and graphite high temperature fuel. The main objectives of the new experiments are to provide first-of-a-kind high quality experimental data on: 1) The criticality of simple, easy to interpret, single core region LEU HTR systems for several moderator-to-fuel ratios and several lattice geometries; 2) the changes in reactivity, neutron balance components and control rod effectiveness caused by water ingress into this type of reactor, and 3) the effects of the boron and/or hafnium absorbers that are used to modify the reactivity and the power distributions in typical HTR systems. Work on the design and licensing of the modified PROTEUS critical facility is now in progress with the HTR experiments scheduled to begin early in 1991. Several international partners will be involved in the planning, execution and analysis of these experiments in order to insure that they are relevant and cost effective with respect to the various gas cooled reactor national programs. (author)

Status of Research on Pebble Bed HTR Fuel Fabrication Technology in Indonesia

International Nuclear Information System (INIS)

Rachmawati, M.; Sarjono; Ridwan; Langenati, R.

2014-01-01

Research on pebble bed HTR fuel fabrication is conducted in Indonesia. One of the aims is to build a knowledge base on pebble bed HTR fuel element fabrication technology for fuel procurement. The steps of research strategies are firstly to understand the basic design research of TRISO fuel, properties, and requirements, and secondly to understand the TRISO fuel manufacturing technology, which comprises fabrication and quality control, including its facility. Both steps are adopted from research and experiences of the countries with HTR fuel element fabrication technology. From the knowledge gained in the research, an experimental design of the process and a set of prototype process equipment for fabrication are developed, namely kernels production using external gelation process, TRISO coating of the kernel, and pebble compacting. Experiments using the prototypes have been conducted. Characterization of the kernel product, i.e. diameter, sphericity, density and O/U ratio, shows that the kernel product is still not in compliance with the specification requirements. These are deemed to be caused mainly by the selected vibrating system and the viscosity adjustment. Another major cause is the selected NH3 and air feeding method for both NH3 and air layer in the preparation for spherical droplets of liquid. The FB-CVD TRISO coating of the kernel has been experimented but unsuccessful by using an FB-CVD once‐through continuous coating process. For the pebble compacting, the process is still in the early stage of setting-up compaction equipment. This paper summarizes the current status of research on HTR fuel fabrication technology in Indonesia, the proposed process and its equipment setting-up for improvement of the kernel production. The knowledge and lessons learned gained from the research is useful and can be an assistance in planning for fuel development laboratory facilities procurement, formulating User Requirement Document and Bid Invitation Specification for

Analysis the Response Function of the HTR Ex-core Neutron Detectors in Different Core Status

International Nuclear Information System (INIS)

Fan Kai; Li Fu; Zhou Xuhua

2014-01-01

Modular high temperature gas cooled reactor HTR-PM demonstration plant, designed by INET, Tsinghua University, is being built in Shidao Bay, Shandong province, China. HTR-PM adopts pebble bed concept. The harmonic synthesis method has been developed to reconstruct the power distributions on HTR-PM. The method based on the assumption that the neutron detector readings are mainly determined by the status of the core through the power distribution, and the response functions changed little when the status of the core changed. To verify the assumption, the influence factors to the ex-core neutron detectors are calculated in this paper, including the control rod position and the temperature of the core. The results shows that when the status of the core changed, the power distribution changed more remarkable than the response function, but the detector readings could change about 5% because of the response function changing. (author)

PCTR experiments with HTR lattice in MARIUS

Energy Technology Data Exchange (ETDEWEB)

Gambier, G; Estiot, J C; de Lapperent, D; Laponche, B; Luffin, J; Morier, F

1972-06-15

PCTR experiments have been carried out in Marius III with HTR tubular fuel, enriched to around 1% in order to reach K{sub infinity} = 1 and to reduce the mass of poison. Three poisons were used - Aluminium, Copper and Vanadium. The effect of air was measured and corrections were made to the results to allow the effect of delayed neutrons and the effect of axial heterogeneities. Interpretation was made with APOLLO. (auth)

Market prospects of modular HTR in EEC countries

International Nuclear Information System (INIS)

Albisu, F.; Garribba, S.F.; Lefevre, J.C.; Leuchs, D.; Vivante, C.

1991-01-01

The energy outlook for the early 21st century is very uncertain. Low-cost oil and natural gas reserves will become seriously depleted and nonfossil energy resources may be urgently required because of environmental reasons. In this framework, small- and medium-size nuclear reactors (SMSNRs), particularly the Modular High-Temperature Reactor (HTR) would allow extension of uses of nuclear energy while being adopted to produce power and/or steam or heat, where heat can be at low or high temperature. For policy making and planning purposes it is meaningful to appraise the market potential of Modular HTR during the next 20 or 30 years. The paper presents the outcomes of country studies on the subject conducted for a sample of EC Member nations, including France, Federal Republic of Germany, Italy, and Spain. Among the goals of the studies are the definition of market segments, and identification of the principal obstacles which will affect future adoption of SMSNRs. Opportunities offered by the different contexts and energy end-uses seem promising. Numerous difficulties and constraints emerge, however, some of which might be eased by actions that national governments or more often the European Community may wish to take. (author)

HTR System Integration in Europe and South Africa

International Nuclear Information System (INIS)

Roelofs, Ferry; Ruer, J.; Cuadrado Garcia, P.; Cetnar, J.; Knoche, D.; Lapins, J.; Kasselman, S.; Stoker, P.; Fütterer, M.

2014-01-01

An HTR can be used for production of electricity and process heat. When these two applications are combined, a multitude of systems and components are needed. Whilst meeting the end user needs, this multitude of systems and components has to operate safely and economically. Therefore, within the framework of the European 7th framework program ARCHER project, a design schematic of a nuclear cogeneration system connected to a European and a South African industrial process is established and assessed. In order to provide an objective overview of the different indicators important for decision makers, the main characteristics with respect to the HTR system, the environment, safety, and economics are identified and compared to the characteristics of a modern gas turbine plant. In addition, a gap and SWOT analysis of a nuclear cogeneration system in Europe and South Africa are presented. In order to enable technical analysis of such a nuclear cogeneration system, a multitude of computer codes will be needed. Therefore, a code inventory is established of codes being used in Europe and South Africa for which the requirements for integration, development and qualification are assessed. (author)

Approach to equilibrium calculations for the dragon HTR design

Energy Technology Data Exchange (ETDEWEB)

Hansen, U

1971-06-10

The calculational methods and the model used in representing the core and the fuel management operations are described. Different layouts of the first core and approach to equilibrium schemes for the Dragon HTR design are investigated. A simple fuelling modus is found and the tchnological and economical implications are discussed in detail.

Digital Distributed Control System Design: Control Policy for Shared Objects in HTR-PM

International Nuclear Information System (INIS)

Zhou Shuqiao; Huang Xiaojin

2014-01-01

HTR-PM is an HTR demonstration plant with a structure of two modules feeding one steam turbine. Compared with the structure of one single reactor feeding one turbine, there are more devices shared between these two modules. When they are operated, the shared components are prone to introduce collisions or even logical deadlocks for different technical processes. The future commercial HTR-PM plants are supposed to comprise more modules for a larger turbine, thus the collision problem introduced by the shared components may become severer. Therefore, how to design suitable policies in the distributed control system (DCS) to relieve the collisions during using these shared devices is a new and also a very important problem. In this paper, the classifications of the shared devices are first addressed, and then how to identify the shared objects of an NPP is proposed. Furthermore, a general model for the control logic design is proposed, taking into consideration the collision avoidance, time delay and fairness. The example of how to apply the schemes to relieve the conflicts and deadlocks in the processes of using the shared devices in fuel element cycling system is illustrated. (author)

Pre-economic analysis of HTR in preparation for a comprehensive economic assessment of HTRs in the world

Energy Technology Data Exchange (ETDEWEB)

Bredimas, Alexandre, E-mail: alexandre.bredimas@strane-innovation.com

2014-05-01

High temperature nuclear reactors will address mainly the industrial cogeneration market and compete with gas cogeneration, the current reference technology. The key question for HTR is therefore: how far are HTRs competitive against gas technologies? This simple question demands a complex response. First, the cogeneration scheme has to be discussed according the specificities in heat usage of every industry as they will impact the design. Second, the costs, revenues and risks of the different lifecycle phases for both a HTR and gas cogeneration plant have to be assessed and compared. These parameters will greatly depend on each location (personnel costs, gas local prices, CO{sub 2} pricing, etc.). A particular attention has to be given to the risk interactions between the cogeneration plant and the industrial facility it is supplying with heat and electricity (e.g. tritium contamination in industrial processes, explosion of flammable products in industrial site). This paper aims mainly at starting exchanges at international level with other equivalent initiatives in order to assess in general terms the economic viability of HTR worldwide, in relation to the evaluation of the HTR global market.

Pre-economic analysis of HTR in preparation for a comprehensive economic assessment of HTRs in the world

International Nuclear Information System (INIS)

Bredimas, Alexandre

2014-01-01

High temperature nuclear reactors will address mainly the industrial cogeneration market and compete with gas cogeneration, the current reference technology. The key question for HTR is therefore: how far are HTRs competitive against gas technologies? This simple question demands a complex response. First, the cogeneration scheme has to be discussed according the specificities in heat usage of every industry as they will impact the design. Second, the costs, revenues and risks of the different lifecycle phases for both a HTR and gas cogeneration plant have to be assessed and compared. These parameters will greatly depend on each location (personnel costs, gas local prices, CO 2 pricing, etc.). A particular attention has to be given to the risk interactions between the cogeneration plant and the industrial facility it is supplying with heat and electricity (e.g. tritium contamination in industrial processes, explosion of flammable products in industrial site). This paper aims mainly at starting exchanges at international level with other equivalent initiatives in order to assess in general terms the economic viability of HTR worldwide, in relation to the evaluation of the HTR global market

The properties of spherical fuel elements and its behavior in the modular HTR

International Nuclear Information System (INIS)

Lohnert, G.H.; Ragoss, H.

1985-01-01

The reference fuel element for all future HTR applications in the Federal Republic of Germany as developed by NUKEM/HOBEG in the framework of the 'High temperature Fuel-Cycle Project' had to be scrutinised for its compatibility with all the other design principles of the modular HTR, or possibly for restrictions forced upon reactor layout. This reference fuel element can be characterized by the following features: moulded spherical fuel element of 60 mm in diameter with fuel free shell of 5 mm thickness, based on carbon matrix; low enriched uranium (U/Pu fuel cycle); UO 2 fuel kernels; TRISO coating (pyrocarbon and additional SiC layers)

Potential of thorium use in the HTR reactor

International Nuclear Information System (INIS)

Engelmann, P.; Hansen, U.; Kolb, G.; Leushacke, D.; Teuchert, E.; Werner, H.

1979-08-01

In this investigation, several types of reactors and fuel circulations are dealt with as they refer to the region of the Federal Republic of Germany and are compared with each other as to their need for uranium and their costs until 2100. This includes also an investigation covering the effects of a postponed application of uranium-saving reactors, a delayed reprocessing and two variants of the nuclear energy's contribution to electricity generation. After today's light water reactor (LWR) of the pressure water reactor type (DWR) and the sodium-cooled fast breeder (SBR) which is being developed, the technically rather developed helium-cooled high temperature reactor (HTR) is dealt with as another system. The high temperature reactor is, because of its high coolant temperatures, not only suitable as a nuclear power plant, but can also be used to substitute fossile energy sources on the heat market and is being developed in Germany also for use as process heat reactor for nuclear coal gasification. Here the application of nuclear energy is only considered with regard to the region of power generation. Besides the case of the LWR and HTR-operation without reprocessing and fuel recycling for all reactor systems, the calculations also take into consideration the case of the closed fuel recycling. While LWR and SBR are based on the uranium-plutonium-fuel recycling, the thorium-uranium fuel circulation is considered for the HTR with globular fuel elements. As investigations made until today are generally restricted to the system LWR/SBR and the uranium-plutonium circulation, a main concern of the investigations presented here is to show the potential of the Thorium-utilization in high-temperature reactors and to determine how this system can also be applied during the time period concerned to set up a nuclear energy strategy which is safe and profitable as far as the uranium supply is concerned. (orig./UA) 891 UA/orig.- 892 HIS [de

The Dragon project and high temperature reactor (HTR position)

International Nuclear Information System (INIS)

Shepherd, L.

1981-01-01

After introduction describing the initiation of HTR work at AERE and in West Germany and the USA, the subject is discussed in detail under the headings: the Dragon Reactor Experiment (design and objectives); fuel elements and graphite (description of cooperative research programmes; development of coated fuel particles); helium technology; other Dragon activities. (U.K.)

Gene structure and expression of serotonin receptor HTR2C in hypothalamic samples from infanticidal and control sows

Directory of Open Access Journals (Sweden)

Quilter Claire R

2012-04-01

Full Text Available Abstract Background The serotonin pathways have been implicated in behavioural phenotypes in a number of species, including human, rat, mouse, dog and chicken. Components of the pathways, including the receptors, are major targets for drugs used to treat a variety of physiological and psychiatric conditions in humans. In our previous studies we have identified genetic loci potentially contributing to maternal infanticide in pigs, which includes a locus on the porcine X chromosome long arm. The serotonin receptor HTR2C maps to this region, and is therefore an attractive candidate for further study based on its function and its position in the genome. Results In this paper we describe the structure of the major transcripts produced from the porcine HTR2C locus using cDNA prepared from porcine hypothalamic and pooled total brain samples. We have confirmed conservation of sites altered by RNA editing in other mammalian species, and identified polymorphisms in the gene sequence. Finally, we have analysed expression and editing of HTR2C in hypothalamus samples from infanticidal and control animals. Conclusions The results confirm that although the expression of the long transcriptional variant of HTR2C is raised in infanticidal animals, the overall patterns of editing in the hypothalamus are similar between the two states. Sequences associated with the cDNA and genomic structures of HTR2C reported in this paper are deposited in GenBank under accession numbers FR720593, FR720594 and FR744452.

Steroid hormones modulate galectin-1 in the trophoblast HTR-8/SVneocell line

Directory of Open Access Journals (Sweden)

Bojić-Trbojević Žanka

2008-01-01

Full Text Available The effects of steroids on galectin-1 (gal-1 were studied in HTR-8/SVneo cells by immunocytochemistry, cell-based ELISA, the MTT proliferation test and the Matrigel TM invasion test. Dexamethasone (DEX, progesterone (PRG, and mifepristone (RU486 were used. Gal-1 was modulated in a steroid- and dose-dependent manner by DEX, which mildly but significantly stimulated production at low concentrations (0.1-10 nM, and inhibited it at 100 nM, while the effects of PRG and RU486 were opposite. HTR-8/SVneo cell invasion of Matrigel was significantly decreased in the presence of DEX and lactose. The obtained data support the proposed regulatory role of steroids in trophoblast gal-1 production.

Stress analysis of HTR-10 steam generator heat exchanging tubes

International Nuclear Information System (INIS)

Dong Jianling; Zhang Xiaohang; Yin Dejian; Fu Jiyang

2001-01-01

Steam Generator (SG) heat exchanging tubes of 10 MW High Temperature Gas Cooled Reactor (HTR-10) are protective screens between the primary loop of helium with radioactivity and the secondary loop of feeding water and steam without radioactivity. Water and steam will enter into the primary loop when rupture of the heat exchanging tubes occurs, which lead to increase of the primary loop pressure and discharge of radioactive materials. Therefore it is important to guarantee the integrity of the tubes. The tube structure is spiral tube with small bending radius, which make it impossible to test with volumetric in-service detection. For such kind of spiral tube, using LBB concept to guarantee the integrity of the tubes is an important option. The author conducts stress analysis and calculation of HTR-10 SG heat exchanging tubes using the FEM code of piping stress analysis, PIPESTRESS. The maximum stress and the dangerous positions are obtained

Association of serotonin transporter (SLC6A4 & receptor (5HTR1A, 5HTR2A polymorphisms with response to treatment with escitalopram in patients with major depressive disorder : A preliminary study

Directory of Open Access Journals (Sweden)

Aniruddha Basu

2015-01-01

Full Text Available Background & objectives: Genetic factors have potential of predicting response to antidepressants in patients with major depressive disorder (MDD. In this study, an attempt was made to find an association between response to escitalopram in patients with MDD, and serotonin transporter (SLC6A4 and receptor (5HTR1A, 5HTR2A polymorphisms. Methods: Fifty five patients diagnosed as suffering from MDD, were selected for the study. The patients were treated with escitalopram over a period of 6-8 wk. Severity of depression, response to treatment and side effects were assessed using standardised instruments. Genetic variations from HTR1A (rs6295, HTR2A (rs6311 and rs6313 and SLC6A4 (44 base-pair insertion/deletion at 5-HTTLPR were genotyped. The genetic data of the responders and non-responders were compared to assess the role of genetic variants in therapeutic outcome. Results: Thirty six (65.5% patients responded to treatment, and 19 (34.5% had complete remission. No association was observed for genotype and allelic frequencies of single nucleotide polymorphisms (SNPs among remitter/non-remitter and responder/non-responder groups, and six most common side-effects, except memory loss which was significantly associated with rs6311 ( p0 =0.03. Interpretation & conclusions: No significant association was found between the SNPs analysed and response to escitalopram in patients with MDD though a significant association was seen between the side effect of memory loss and rs6311. Studies with larger sample are required to find out genetic basis of antidepressant response in Indian patients.

Development of a Reliable Fuel Depletion Methodology for the HTR-10 Spent Fuel Analysis

Energy Technology Data Exchange (ETDEWEB)

Chung, Kiwhan [Los Alamos National Laboratory; Beddingfield, David H. [Los Alamos National Laboratory; Geist, William H. [Los Alamos National Laboratory; Lee, Sang-Yoon [unaffiliated

2012-07-03

A technical working group formed in 2007 between NNSA and CAEA to develop a reliable fuel depletion method for HTR-10 based on MCNPX and to analyze the isotopic inventory and radiation source terms of the HTR-10 spent fuel. Conclusions of this presentation are: (1) Established a fuel depletion methodology and demonstrated its safeguards application; (2) Proliferation resistant at high discharge burnup ({approx}80 GWD/MtHM) - Unfavorable isotopics, high number of pebbles needed, harder to reprocess pebbles; (3) SF should remain under safeguards comparable to that of LWR; and (4) Diversion scenarios not considered, but can be performed.

Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome

Energy Technology Data Exchange (ETDEWEB)

Gelernter, J.; Rao, P.A.; Pauls, D.L. [Yale Univ. School of Medicine, West Haven, CT (United States)] [and others

1995-03-20

A novel serotonin receptor designated 5HT7 (genetic locus HTR7) was cloned in 1993. This receptor has interesting properties related to ligand affinity and CNS distribution that render HTR7 a very interesting candidate gene for neuropsychiatric disorders. We mapped this gene, first by physical methods and then by genetic linkage. First, we made a tentative assignment to chromosome 10, based on hybridization of an HTR7 probe to a Southern blot of DNA from somatic cell hybrids. We then identified a genetic polymorphism at the HTR7 locus. We identified one extended pedigree where the polymorphism segregated. Using the LEPED computer program for pairwise linkage analysis, we confirmed the assignment of the gene to chromosome 10, specifically 10q21-q24, based on a lod score of 5.37 at 0% recombination between HTR7 and D10S20 (a chromosome 10 reference marker). Finally, we excluded genetic linkage between this locus and Tourette syndrome under a reasonable set of assumptions. 15 refs., 1 fig., 1 tab.

Intermediate heat exchanger for HTR process heat application

International Nuclear Information System (INIS)

Crambes, M.

1980-01-01

In the French study on the nuclear gasification of coal, the following options were recommended: Coal hydrogenation, the hydrogen being derived from CH 4 reforming under the effects of HTR heat; the use of an intermediate helium circuit between the nuclear plant and the reforming plant. The purpose of the present paper is to describe the heat exchanger designed to transfer heat from the primary to the intermediate circuit

IRPhE-HTR-ARCH-01, Archive of HTR Primary Documents

International Nuclear Information System (INIS)

2004-01-01

Description: High Temperature Reactor Studies, including experiments in critical facilities or in prototypes have been carried out in the past. Information gathered, experience gained and experimental data produced are of value for the development of future advanced HTRs. For the purpose of knowledge, competence, information preservation and management, computer readable archives have been established. The present archive includes several relevant documents relative to the following: - Graphite Moderated Critical Facility, CESAR at Cadarache. Dragon Countries Physics Meetings (DCPM); - OTTO Pebble Bed Reactors; - Gulf - HTGR Experiments; - Zero Power MARIUS Reactor; - Pebble-bed KAHTER Critical Facility; - Helium Cooled Fast Reactor Assessment Studies; - Gas Cooled Reactor Technology Safety and Siting; - Initial Evaluation of the Gas-Turbine Modules HTGCR; - A report on Nuclear Graphite; - AVR Reactor Juelich (new in version 02); - HTR IAEA proceedings (new in version 02); - Studies at IRI Delft(new in version 02); - Studies and experiments at PSI Villigen (new in version 02); 2 - Related or auxiliary information: IRPHE-DRAGON-DPR, high Temperature Reactor Dragon Project, Primary Documents NEA-1726/01. 3 - Software requirements: Acrobat Reader, Microsoft Word, HTML Browser required

A Statistical Analysis on the Coating Layer Thicknesses of a TRISO of 350 MWth Block-type HTR

Energy Technology Data Exchange (ETDEWEB)

Kim, Young Min; Jo, C. K.; Cho, M. S. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2016-10-15

A tri-isotropic coated fuel particle (TRISO) is a basic fuel element of a high temperature reactor (HTR). The block-type HTR fuel is a cylindrical graphite compact in which a large number of TRISOs are embedded. There are more than 11 billion TRISOs in a 350 MW{sub th} block-type HTR core. Among the RSM quadratic models, the BBD model produces the smallest errors at both interior and exterior points. The errors in the quadratic model of the small-type CCD is the biggest, particularly at exterior points. The CCD has a disadvantage of generating a number of decimal places in its factor levels because of its axial points. It is recommended to use the BBD or the full-type CCD with an adjusted axial point which does not produce the decimal places in its factor levels. More general statistical model for a TRISO design will be secured when the number of factors and responses increases. This study treats a statistical analysis on the optimal layer thicknesses of a UCO TRISO of 350 MW{sub th} block-type HTR which cause a minimum tangential stress to act on the SiC layer. Three response surface methods (RSMs) are used as statistical methods and their resulting quadratic models are compared.

A Statistical Analysis on the Coating Layer Thicknesses of a TRISO of 350 MWth Block-type HTR

International Nuclear Information System (INIS)

Kim, Young Min; Jo, C. K.; Cho, M. S.

2016-01-01

A tri-isotropic coated fuel particle (TRISO) is a basic fuel element of a high temperature reactor (HTR). The block-type HTR fuel is a cylindrical graphite compact in which a large number of TRISOs are embedded. There are more than 11 billion TRISOs in a 350 MW_t_h block-type HTR core. Among the RSM quadratic models, the BBD model produces the smallest errors at both interior and exterior points. The errors in the quadratic model of the small-type CCD is the biggest, particularly at exterior points. The CCD has a disadvantage of generating a number of decimal places in its factor levels because of its axial points. It is recommended to use the BBD or the full-type CCD with an adjusted axial point which does not produce the decimal places in its factor levels. More general statistical model for a TRISO design will be secured when the number of factors and responses increases. This study treats a statistical analysis on the optimal layer thicknesses of a UCO TRISO of 350 MW_t_h block-type HTR which cause a minimum tangential stress to act on the SiC layer. Three response surface methods (RSMs) are used as statistical methods and their resulting quadratic models are compared

New Developments in Actinides Burning with Symbiotic LWR-HTR-GCFR Fuel Cycles

International Nuclear Information System (INIS)

Bomboni, Eleonora

2008-01-01

The long-term radiotoxicity of the final waste is currently the main drawback of nuclear power production. Particularly, isotopes of Neptunium and Plutonium along with some long-lived fission products are dangerous for more than 100000 years. 96% of spent Light Water Reactor (LWR) fuel consists of actinides, hence it is able to produce a lot of energy by fission if recycled. Goals of Generation IV Initiative are reduction of long-term radiotoxicity of waste to be stored in geological repositories, a better exploitation of nuclear fuel resources and proliferation resistance. Actually, all these issues are intrinsically connected with each other. It is quite clear that these goals can be achieved only by combining different concepts of Gen. IV nuclear cores in a 'symbiotic' way. Light-Water Reactor - (Very) High Temperature Reactor ((V)HTR) - Fast Reactor (FR) symbiotic cycles have good capabilities from the viewpoints mentioned above. Particularly, HTR fuelled by Plutonium oxide is able to reach an ultra-high burn-up and to burn Neptunium and Plutonium effectively. In contrast, not negligible amounts of Americium and Curium build up in this core, although the total mass of Heavy Metals (HM) is reduced. Americium and Curium are characterised by an high radiological hazard as well. Nevertheless, at least Plutonium from HTR (rich in non-fissile nuclides) and, if appropriate, Americium can be used as fuel for Fast Reactors. If necessary, dedicated assemblies for Minor Actinides (MA) burning can be inserted in Fast Reactors cores. This presentation focuses on combining HTR and Gas Cooled Fast Reactor (GCFR) concepts, fuelled by spent LWR fuel and depleted uranium if need be, to obtain a net reduction of total mass and radiotoxicity of final waste. The intrinsic proliferation resistance of this cycle is highlighted as well. Additionally, some hints about possible Curium management strategies are supplied. Besides, a preliminary assessment of different chemical forms of

Expression and biological-clinical significance of hTR, hTERT and CKS2 in washing fluids of patients with bladder cancer

Directory of Open Access Journals (Sweden)

Talesa Vincenzo N

2010-10-01

Full Text Available Abstract Background at present, pathogenesis of bladder cancer (BC has not been fully elucidated. Aim of this study is to investigate the role of human telomerase RNA (hTR, human telomerase reverse transcriptase (hTERT and CDC28 protein kinase regulatory subunit 2 (CKS2 in bladder carcinogenesis and their possible clinical significance; Methods the transcript levels of hTR, hTERT and CKS2 were quantified by Real time reverse transcriptase chain reaction in exfoliated cells from bladder washings of 36 patients with BC and 58 controls. The statistical significance of differences between BC bearing patients and control groups, in the general as well as in the stratified analysis (superficial or invasive BC, was assessed by Student's t test. Non parametric Receiver Operating Characteristics analysis (ROC was performed to ascertain the accuracy of study variables to discriminate between BC and controls. The clinical value of concomitant examination of hTR, hTERT and CKS2 was evaluated by logistic regression analysis; Results a significant decrease in hTR and a significant increase in hTERT or CKS2 gene expression were found between BC bearing patients and controls, as well as in the subgroups analysis. The area under the curve (AUC indicated an average discrimination power for the three genes, both in the general and subgroups analysis, when singularly considered. The ability to significantly discriminate between superficial and invasive BC was observed only for hTR transcript levels. A combined model including hTR and CKS2 was the best one in BC diagnosis; Conclusions our results, obtained from a sample set particularly rich of exfoliated cells, provide further molecular evidence on the involvement of hTR, hTERT and CKS2 gene expression in BC carcinogenesis. In particular, while hTERT and CKS2 gene expression seems to have a major involvement in the early stages of the disease, hTR gene expression, seems to be more involved in progression. In

Design investigation of the HTR for the opening of very heavy oil deposits

International Nuclear Information System (INIS)

Gao, Z.

1985-02-01

In the north-east of China there are rich deposits of very heavy oil, which are to be found in a depth of 1500-1700 m. For opening an interaction of 370-390 0 Celsius steam is necessary. The HTR is well suited to produce the steam. A nuclear heat source of 1000 MWsub(th) makes possible the production of 1.5 million tons oil per year. This is a 30-40 per cent higher production of oil compared to the oil-fired steam production. Two concepts of smaller pebble bed reactors are suited as heat sources: the HTR-MEDUL-334 with a thermal power of the 334 MW and fuelled in the multiple run-through scheme and the HTR-OTTO-200 with 200 MW and once-through fuelling. Three or five reactors can be combined in the modular way to provide the power of 1000 MW. For both reactors the design, the neutron-physical and thermohydraulic behaviour are followed in the computer simulation. A central zone of the pebble bed reactor is fuelled with elements of strongly reduced fissile content. Due to the reduced power density the maximum fuel temperature appearing in extreme accidents is limited and accordingly the release of the fission products is avoided. (orig.) [de

Source Term Analysis of the Irradiated Graphite in the Core of HTR-10

Directory of Open Access Journals (Sweden)

Xuegang Liu

2017-01-01

Full Text Available The high temperature gas-cooled reactor (HTGR has potential utilization due to its featured characteristics such as inherent safety and wide diversity of utilization. One distinct difference between HTGR and traditional pressurized water reactor (PWR is the large inventory of graphite in the core acting as reflector, moderator, or structure materials. Some radionuclides will be generated in graphite during the period of irradiation, which play significant roles in reactor safety, environmental release, waste disposal, and so forth. Based on the actual operation of the 10 MW pebble bed high temperature gas-cooled reactor (HTR-10 in Tsinghua University, China, an experimental study on source term analysis of the irradiated graphite has been done. An irradiated graphite sphere was randomly collected from the core of HTR-10 as sample in this study. This paper focuses on the analytical procedure and the establishment of the analytical methodology, including the sample collection, graphite sample preparation, and analytical parameters. The results reveal that the Co-60, Cs-137, Eu-152, and Eu-154 are the major γ contributors, while H-3 and C-14 are the dominating β emitting nuclides in postirradiation graphite material of HTR-10. The distribution profiles of the above four nuclides are also presented.

The role of Omi/HtrA2 protease in neonatal postasphyxial serum-induced apoptosis in human kidney proximal tubule cells

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Zhang Yong

2012-01-01

Full Text Available Omi/HtrA2, a proapoptotic mitochondrial serine protease, is involved in both caspase-dependent and caspaseindependent apoptosis. A growing body of evidence indicates that Omi/HtrA2 plays an important role in the pathogenesis of a variety of ischemia-reperfusion (I/R injuries. However, the role of Omi/HtrA2 in renal injuries that occur in neonates with asphyxia remains unknown. The present study was designed to investigate whether Omi/HtrA2 plays an important role in the types of renal injuries that are induced by neonatal postasphyxial serum. Human renal proximal tubular cell line (HK-2 cells were used as targets. A 20% serum taken from neonates one day after asphyxia was applied to target cells as an attacking factor. We initially included control and postasphyxial serum-attacked groups and later included a ucf-101 group in the study. In the postasphyxial serum-treated group, cytosolic Omi/HtrA2 and caspase-3 expression in HK-2 cells was significantly higher than in the control group. Moreover, the concentration of cytosolic caspase-3 was found to be markedly decreased in HK-2 cells in the ucf-101 group. Our results suggest both that postasphyxial serum has a potent apoptosis-inducing effect on HK-2 cells and that this effect can be partially blocked by ucf-101. Taken together, our results demonstrate for the first time that postasphyxial serum from neonates results in Omi/HtrA2 translocation from the mitochondria to the cytosol, where it promotes HK-2 cell apoptosis via a protease activity-dependent, caspase-mediated pathway.

Regulation of HtrA2 on WT1 gene expression under imatinib stimulation and its effects on the cell biology of K562 cells.

Science.gov (United States)

Zhang, Lixia; Li, Yan; Li, Xiaoyan; Zhang, Qing; Qiu, Shaowei; Zhang, Qi; Wang, Min; Xing, Haiyan; Rao, Qing; Tian, Zheng; Tang, Kejing; Wang, Jianxiang; Mi, Yingchang

2017-09-01

The aim of the present study was to investigate the regulation of Wilms Tumor 1 (WT1) by serine protease high-temperature requirement protein A2 (HtrA2), a member of the Htr family, in K562 cells. In addition, the study aimed to observe the effect of this regulation on cell biological functions and its associated mechanisms. Expression of WT1 and HtrA2 mRNA, and proteins following imatinib and the HtrA2 inhibitor 5-[5-(2-nitrophenyl) furfuryl iodine]-1, 3-diphenyl-2-thiobarbituric acid (UCF-101) treatment was detected with reverse transcription-quantitative polymerase chain reaction and western blot analysis. Subsequent to treatment with drugs and UCF-101, the proliferative function of K562 cells was detected using MTT assays, and the rate of apoptosis was detected using Annexin V with propidium iodide flow cytometry in K562 cells. The protein levels in the signaling pathway were analyzed using western blotting following treatment with imatinib and UCF-101. In K562 cells, imatinib treatment activated HtrA2 gene at a transcription level, while the WT1 gene was simultaneously downregulated. Following HtrA2 inhibitor (UCF-101) treatment, the downregulation of WT1 increased gradually. At the protein level, imatinib induced the increase in HtrA2 protein level and concomitantly downregulated WT1 protein level. Subsequent to HtrA2 inhibition by UCF-101, the WT1 protein level decreased temporarily, but eventually increased. Imatinib induced apoptosis in K562 cells, but this effect was attenuated by the HtrA2 inhibitor UCF-101, resulting in the upregulation of the WT1 protein level. However; UCF-101 did not markedly change the proliferation inhibition caused by imatinib. Imatinib activated the p38 mitogen activated protein kinase (p38 MAPK) signaling pathway in K562 cells, and UCF-101 affected the activation of imatinib in the p38 MAPK signaling pathway. Imatinib inhibited the extracellular signal-related kinase (ERK1/2) pathway markedly and persistently, but UCF-101

Studies of magnetism with inelastic scattering of cold neutrons; Etudes de magnetisme realisees a l'aide de la diffusion inelastique de neutrons froids

Energy Technology Data Exchange (ETDEWEB)

Jacrot, B [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

Inelastic scattering of cold neutrons can be used to study some aspects of magnetism: spins waves, exchange integrals, vicinity of Curie point. After description of the experimental set-up, several experiments, in the fields mentioned above, are analysed. (author) [French] La technique de diffusion inelastique des neutrons froids est utilisee pour etudier certains aspects du magnetisme: ondes de spins, integrales d'echange, etude au voisinage du point de Curie, etc. Apres une description de l'appareillage, on analyse diverses experiences effectuees dans les domaines enumeres plus haut. (auteur)

Radiation Protection Practices during the Helium Circulator Maintenance of the 10 MW High Temperature Gas-Cooled Reactor-Test Module (HTR-10

Directory of Open Access Journals (Sweden)

Chengxiang Guo

2016-01-01

Full Text Available Current radiation protection methodology offers abundant experiences on light-water reactors, but very few studies on high temperature gas-cooled reactor (HTR. To fill this gap, a comprehensive investigation was performed to the radiation protection practices in the helium circulator maintenance of the Chinese 10 MW HTR test module (HTR-10 in this paper. The investigation reveals the unique behaviour of HTR-10’s radiation sources in the maintenance as well as its radionuclide species and presents the radiation protection methods that were tailored to these features. Owing to these practices, the radioactivity level was kept low throughout the maintenance and only low-level radioactive waste was generated. The quantitative analysis further demonstrates that the decontamination efficiency was over 89% for surface contamination and over 34% for γ dose rate and the occupational exposure was much lower than both the limits of regulatory and the exposure levels in comparable literature. These results demonstrate the effectiveness of the reported radiation protection practices, which directly provides hands-on experience for the future HTR-PM reactor and adds to the completeness of the radiation protection methodology.

Costs of head-end incineration with respect to Kr separation in the reprocessing of HTR fuel elements

Energy Technology Data Exchange (ETDEWEB)

Barnert-Wiemer, H.; Boehnert, R.

1976-07-15

The C-incinerations and the Kr-separations during head-end incineration in the reprocessing of HTR fuel elements are described. The costs for constructing an operating a head-end incineration of reprocessing capacities with 5,000 to 50,000 MW(e)-HTR power have been determined. The cost estimates are divided into investment and operating costs, further after the fraction of the N/sub 2/-content in the incineration exhaust gas, which strongly affects costs. It appears that, in the case of Kr-separation from the incineration exhaust gas, the investment costs as well as the operating costs of the head-end for N/sub 2/-containing exhaust gas are considerably greater than those for gas without N/sub 2/. The C-incineration of the graphite of the HTR fuel elements should therefore only be performed with influx gas that is free of N/sub 2/.

Burning minor actinides in a HTR energy spectrum

International Nuclear Information System (INIS)

Pohl, Christoph; Rütten, H. Jochem

2012-01-01

Highlights: ► Burn-up analysis for varying plutonium/minor actinide fuel compositions. ► The influence of varying heavy metal fuel element loads is investigated. ► Significant burn-up via radiative capture and subsequently fission is observed. ► Difference observed between fuel element burn-up and total actinide burning rate. - Abstract: The generation of nuclear energy by means of the existing nuclear reactor systems is based mainly on the fission of U-235. But this comes along with the capture of neutrons by the U-238 faction and results in a build-up of plutonium isotopes and minor actinides as neptunium, americium and curium. These actinides are dominant for the long time assessment of the radiological risk of a final disposal therefore a minimization of the long living isotopes is aspired. Burning the actinides in a high temperature helium cooled graphite moderated reactor (HTR) is one of these options. The use of plutonium isotopes to sustain the criticality of the system is intended to avoid on the one hand highly enriched uranium because of international regulations and on the other hand low enriched uranium because of the build up of new actinides from neutron capture in the U-238 fraction. Because initial minor actinide isotopes are typically not fissionable by thermal neutrons the idea is to fission instead the intermediate isotopes generated by the first neutron capture. This paper comprises calculations for plutonium/minor actinides/thorium fuel compositions and their correlated final burn-up for a generic pebble bed HTR based on the reference design of the 400 MW PBMR. In particular the cross sections and the neutron balance of the different minor actinide isotopes in the higher thermal energy spectrum of a HTR will be discussed. For a fuel mixture of plutonium and minor actinides a significant burn-up of these actinides up to 20% can be achieved but at the expense of a higher residual fraction of plutonium in the burned fuel. Combining

Gadd45 α expression in preeclampsia placenta and the effect of Gadd45 α on trophoblast HTR8/Svneo

Directory of Open Access Journals (Sweden)

Li Wang

2016-01-01

Full Text Available Objective: To study the expression of Gadd45 α in preeclampsia placenta and the regulating effect of Gadd45 α knockdown on trophoblast HTR8/Svneo. Methods: Preeclampsia placenta tissue and normal placenta tissue were collected, and mRNA contents and protein contents of Gadd45 α were detected by fluorescent quantitative PCR and Western blotting respectively; trophoblast cells HTR8/Svneo were cultured and after transfection of Gadd45 α siRNA, cell invasion ability and expression of invasion-assiotiated molecules were detected. Results: mRNA content and protein content of Gadd45 α in preeclampsia placenta tissue were higher than those in normal placenta tissue; after transfection of Gadd45 α siRNA, mRNA content and protein content of Gadd45 α in HTR8/Svneo cells significantly decreased, and the number of invasive cells as well as expression of MMP1, MMP2, MMP3 and MMP9 significantly increased. Conclusion: The expression of Gadd45 α in preeclampsia placenta abnormally increases; inhibting the expression of Gadd45 α in trophoblasts HTR8/Svneo can promote invasion and increase the expression of MMPs molecules.

Different Roles of COMT and HTR2A Genotypes in Working Memory Subprocesses.

Directory of Open Access Journals (Sweden)

Hirohito M Kondo

Full Text Available Working memory is linked to the functions of the frontal areas, in which neural activity is mediated by dopaminergic and serotonergic tones. However, there is no consensus regarding how the dopaminergic and serotonergic systems influence working memory subprocesses. The present study used an imaging genetics approach to examine the interaction between neurochemical functions and working memory performance. We focused on functional polymorphisms of the catechol-O-methyltransferase (COMT Val(158Met and serotonin 2A receptor (HTR2A -1438G/A genes, and devised a delayed recognition task to isolate the encoding, retention, and retrieval processes for visual information. The COMT genotypes affected recognition accuracy, whereas the HTR2A genotypes were associated with recognition response times. Activations specifically related to working memory were found in the right frontal and parietal areas, such as the middle frontal gyrus (MFG, inferior frontal gyrus (IFG, anterior cingulate cortex (ACC, and inferior parietal lobule (IPL. MFG and ACC/IPL activations were sensitive to differences between the COMT genotypes and between the HTR2A genotypes, respectively. Structural equation modeling demonstrated that stronger connectivity in the ACC-MFG and ACC-IFG networks is related to better task performance. The behavioral and fMRI results suggest that the dopaminergic and serotonergic systems play different roles in the working memory subprocesses and modulate closer cooperation between lateral and medial frontal activations.

Market prospects of modular HTR in EEC countries

International Nuclear Information System (INIS)

Albisu, F.; Garribba, S.F.; Lefevre, J.C.; Leuchs, D.; Vivante, C.

1992-01-01

The energy outlook for the early 21st century is very uncertain. Low-cost oil and natural gas reserves will become seriously depleted and non-fossil energy resources may be urgently required because of environmental reasons. In this framework, the European Economic Community should be able to rely upon nuclear energy as an economic, safe and readily deployable resource for its future. Small and medium-size nuclear reactors (SMSNRs), particularly modular high-temperature reactor (HTR) would allow extension of uses of nuclear energy while being adopted to produce power and/or steam or heat, where heat can be at low or high temperature. For policy making and planning purposes it appears meaningful to appraise the market potential of modular HTR during the next twenty or thirty years. Thus the paper presents the outcomes of country studies on the subject conducted for a sample of Member nations to the European Economic Community including France, Federal Republic of Germany, Italy and Spain. Amongst the goals of the studies are definition of market segments, identification of the principal obstacles which would affect future adoption of SMSNRs. Opportunities offered by the different contexts and energy end-uses seem promising. Numerous difficulties and constraints emerge however, some of which might be eased by actions that national governments or more often the European Economic Community, may wish to take. (orig.)

Value-creating investment strategies to manage risk from structural market uncertainties: Switching and compound options in (V)HTR technologies - HTR2008-58157

International Nuclear Information System (INIS)

Lauferts, U.; Halbe, C.; Van Heek, A.

2008-01-01

To measure the value of a technology investment under uncertainty with standard techniques like net present value (NPV) or return on investment (ROI) will often uncover the difficulty to present convincing business case. Projected cash flows are inefficient or the discount rate chosen to compensate for the risk is so high, that it is disagreeable to the investor s requirements. Decision making and feasibility studies have to look beyond traditional analysis to reveal the strategic value of a technology investment. Here, a Real Option Analysis (ROA) offers a powerful alternative to standard discounted cash-flow (DCF) methodology by risk-adjusting the cash flow along the decision path rather than risk adjusting the discount rate. Within the GEN IV initiative attention is brought not only towards better sustainability, but also to broader industrial application and improved financing. Especially the HTR design is full of strategic optionalities: The high temperature output facilitates penetration into other non-electricity energy markets like industrial process heat applications and the hydrogen market. The flexibility to switch output in markets with multi-source uncertainties reduces downside risk and creates an additional value of over 50% with regard to the Net Present Value without flexibility. The supplement value of deploying a modular (V)HTR design adds over 100% to the project value using real option evaluation tools. Focus of this paper was to quantify the strategic value that comes along a) with the modular design; a design that offers managerial flexibility adapting a step-by-step investment strategy to the actual market demand and b) with the option to switch between two modes of operation, namely electricity and hydrogen production. We will demonstrate that the effect of uncertain electricity prices can be dampened down with a modular HTR design. By using a real option approach, we view the project as a series of compound options - each option depending

HTR's role in process heat applications

International Nuclear Information System (INIS)

Kuhr, Reiner

2008-01-01

Advanced high-temperature nuclear reactors create a number of new opportunities for nuclear process heat applications. These opportunities are based on the high-temperature heat available, smaller reactor sizes, and enhanced safety features that allow siting close to process plants. Major sources of value include the displacement of premium fuels and the elimination of CO 2 emissions from combustion of conventional fuels and their use to produce hydrogen. High value applications include steam production and cogeneration, steam methane reforming, and water splitting. Market entry by advanced high-temperature reactor technology is challenged by the evolution of nuclear licensing requirements in countries targeted for early applications, by the development of a customer base not familiar with nuclear technology and related issues, by convergence of oil industry and nuclear industry risk management, by development of public and government policy support, by resolution of nuclear waste and proliferation concerns, and by the development of new business entities and business models to support commercialization. New HTR designs may see a larger opportunity in process heat niche applications than in power given competition from larger advanced light water reactors. Technology development is required in many areas to enable these new applications, including the commercialization of new heat exchangers capable of operating at high temperatures and pressures, convective process reactors and suitable catalysts, water splitting system and component designs, and other process-side requirements. Key forces that will shape these markets include future fuel availability and pricing, implementation and monetization of CO 2 emission limits, and the formation of international energy and environmental policy that will support initiatives to provide the nuclear licensing frameworks and risk distribution needed to support private investment. This paper was developed based on a plenary

HTR-2002: Proceedings of the conference on high temperature reactors

International Nuclear Information System (INIS)

2002-01-01

High temperature reactors are considered as future inherently safe and efficient energy sources. The presentations covered all the relevant aspects of the existing HTGRs and/or helium cooled pebble bed reactors. They were sorted into 7 sessions: HTR Projects and Programmes; Fuel and Fuel Cycle; Physics and Neutronics; Thermohydraulic Calculation; Engineering, Design and Applications; Materials and Components; Safety and Licensing

Experiments in MARIUS on HTR tubular fuel with loose particles

Energy Technology Data Exchange (ETDEWEB)

Bosser, R; Langlet, G

1972-06-15

The work described on HTR tubular fuel with loose particles is the first part of a program in three points. The cell is the same in the three experiments, only particles in the fuel container are changed. The aim of the experiment is to achieve the buckling in a critical facility. A description of the techniques of measurements, calculations, and results are presented.

Survey of HTR related research at IRI, Delft, Netherlands

Energy Technology Data Exchange (ETDEWEB)

Hoogenboom, J.E.; Wallerbos, E.J.M.; Van der Hagen, T.H.J.J.; Van Dam, H. [Interfaculty Reactor Institute IRI, Delft University of Technology, Delft (Netherlands); Tuerkcan, E. [ECN Nuclear Research, Petten (Netherlands)

1998-09-01

High temperature helium-cooled reactors have a large potential for inherent safety. Therefore, several projects on HTR research are being carried out or were carried out at the Interfaculty Reactor Institute (IRI) of the Delft University of Technology in Delft, Netherlands. As part of a larger research programme measurements of core reactivity, reactivity worth of safety rods and of small samples being oscillated in the reactor core were carried out at the PROTEUS facility of the Paul Scherrer Institute at Villigen, Switzerland. Together with other partners in the Netherlands a small inherently safe co-generation plant with a pebble-bed HTR core was designed and analysed. It was verified that such a reactor can operate continuously for 10 years by adding continuously fuel pebbles until the maximum available core height is reached. As a new, innovative, inherently safe reactor type the design of a fluidized-bed reactor with coated fuel particles on a helium gas stream is discussed and results are shown for the analysis of inherent criticality safety under varying coolant flow rates. IRI is also taking part in the new IAEA Co-ordinated Research Programme, which involves participation in the start-up experiments of the Japanese HTTR and carrying out calculations for the core physics benchmark test. 11 refs.

Core dynamics of HTR under ATWS and accident conditions

International Nuclear Information System (INIS)

Nabbi, R.

1988-05-01

The systematic classification of the ATWS has been undertaken by analogy to the considerations made for LWR. The initiating events of ATWS and protection actions of safety systems resulting from monitoring of the system variables have been described. The main emphasis of this work is the analysis of the core dynamic consequences of scram failure during the anticipated transients. The investigation has shown that because of the temperature feedback mechanisms a temperature rise during the ATWS results in a self-shutdown of the reactor. Further inherent safety features of the HTR - conditioned by the high heat capacity of the core and by the compressibility of the coolant - do effectively counteract an undesirable increase of temperature and pressure in the primary circuit. In case of the long-term failure of the forced cooling and following core heatup, neutron physical phenomena appear which determine the reactivity behaviour of the HTR. They are, for instance, the decay of Xenon 135, release of the fission products and subsiding of the top reflector. The results of the computer simulations show that a recriticality has to be excluded during the first 2 days if the reactor is shutdown by the reflector rods at the beginning of the accident. (orig./HP) [de

Accident situations tests HTR fuel with the device Kufa

International Nuclear Information System (INIS)

Kellerbauer, A. I.; Freis, D.

2010-01-01

The ceramic and ceramic-like coating materials in modern high-temperature reactor fuel are designed to ensure mechanical stability and retention of fission products under normal and transient conditions, regardless of the radiation damage sustained in-pile. In hypothetical depressurization and loss-of-forced-circulation (D LOFC) accidents, fuel elements of modular high-temperate reactors are exposed to temperatures several hundred degrees higher than during normal operation, causing increased thermo-mechanical stress on the coating layers. At the Institute for Transuranium Elements of the European Commission, a vigorous experimental program is being pursued with the aim of characterizing the performance of irradiated HTR fuel under such accident conditions. A cold finger device (Kufa), operational in ITUs hot cells since 2006, has been used to perform heating experiments on eight irradiated HTR fuel pebbles from the AVR experimental reactor and from dedicated irradiation campaigns at the High-Flux Reactor in Petten, the Netherlands. Gaseous fission products are collected in a cryogenic charcoal trap, while volatiles,are plated out on a water-cooled condensate plate. A quantitative measurement of the release is obtained by gamma spectroscopy. We highlight experimental results from the Kufa testing as well as the on-going development of new experimental facilities. (Author) 9 refs.

Details of modelling HTR core physics: the use of pseudo nuclide traces

International Nuclear Information System (INIS)

Kuijper, J.C.; Oppe, J.; Haas, J.B.M. de; Da Cruz, D.F.

2003-01-01

At present most combined neutronic and thermal hydraulic analyses of reactors, and the HTR is no exception, are being performed by codes employing few-group (typically 2-group) neutronics on the basis of parametrized few-group macroscopic (and microscopic) cross sections for homogenized areas, depending on quantities like irradiation (fuel only), 135 Xe concentration, temperature, etc. The irradiation parameter (time-integrated power per unit initial heavy metal mass) is sufficient for keeping track of the evolution of areas containing fuel. However, the use of the same parameter in areas without fuel, e.g. containing burnable poison, requires some special provisions. This can be met by the introduction of pseudo nuclides, with very specific cross sections and reaction chains, in the procedure to generate the parametrized few-group cross sections. It is shown that the time-evolution of a non-fuelled burnable poison area, as calculated by the 2-group (HTR) reactor code PANTHERMIX employing pseudo nuclides, compares well to the time-evolution obtained from an explicit burnup calculation by the WIMS8A/SNAP code. Examples are also shown using the pseudo nuclide method to keep track of the fast fluence (time-integrated flux above 0.1 MeV) in a continuous reload pebble-bed HTR reactor calculation by PANTHERMIX. Although the present implementation of the pseudo nuclide method exhibits some peculiarities connected to the specific codes in use (WIMS8A and PANTHERMIX) it is considered to be sufficiently general to be applicable in other code suites, requiring only limited modifications. (authors)

Details of modelling HTR core physics: the use of pseudo nuclide traces

Energy Technology Data Exchange (ETDEWEB)

Kuijper, J.C.; Oppe, J.; Haas, J.B.M. de; Da Cruz, D.F. [Nuclear Research and consultancy Group (NRG), Petten (Netherlands)

2003-07-01

At present most combined neutronic and thermal hydraulic analyses of reactors, and the HTR is no exception, are being performed by codes employing few-group (typically 2-group) neutronics on the basis of parametrized few-group macroscopic (and microscopic) cross sections for homogenized areas, depending on quantities like irradiation (fuel only), {sup 135}Xe concentration, temperature, etc. The irradiation parameter (time-integrated power per unit initial heavy metal mass) is sufficient for keeping track of the evolution of areas containing fuel. However, the use of the same parameter in areas without fuel, e.g. containing burnable poison, requires some special provisions. This can be met by the introduction of pseudo nuclides, with very specific cross sections and reaction chains, in the procedure to generate the parametrized few-group cross sections. It is shown that the time-evolution of a non-fuelled burnable poison area, as calculated by the 2-group (HTR) reactor code PANTHERMIX employing pseudo nuclides, compares well to the time-evolution obtained from an explicit burnup calculation by the WIMS8A/SNAP code. Examples are also shown using the pseudo nuclide method to keep track of the fast fluence (time-integrated flux above 0.1 MeV) in a continuous reload pebble-bed HTR reactor calculation by PANTHERMIX. Although the present implementation of the pseudo nuclide method exhibits some peculiarities connected to the specific codes in use (WIMS8A and PANTHERMIX) it is considered to be sufficiently general to be applicable in other code suites, requiring only limited modifications. (authors)

HTR8/SVneo cells display trophoblast progenitor cell-like characteristics indicative of self-renewal, repopulation activity, and expression of "stemness-" associated transcription factors.

Science.gov (United States)

Weber, Maja; Knoefler, Ilka; Schleussner, Ekkehard; Markert, Udo R; Fitzgerald, Justine S

2013-01-01

JEG3 is a choriocarcinoma--and HTR8/SVneo a transformed extravillous trophoblast--cell line often used to model the physiologically invasive extravillous trophoblast. Past studies suggest that these cell lines possess some stem or progenitor cell characteristics. Aim was to study whether these cells fulfill minimum criteria used to identify stem-like (progenitor) cells. In summary, we found that the expression profile of HTR8/SVneo (CDX2+, NOTCH1+, SOX2+, NANOG+, and OCT-) is distinct from JEG3 (CDX2+ and NOTCH1+) as seen only in human-serum blocked immunocytochemistry. This correlates with HTR8/SVneo's self-renewal capacities, as made visible via spheroid formation and multi-passagability in hanging drops protocols paralleling those used to maintain embryoid bodies. JEG3 displayed only low propensity to form and reform spheroids. HTR8/SVneo spheroids migrated to cover and seemingly repopulate human chorionic villi during confrontation cultures with placental explants in hanging drops. We conclude that HTR8/SVneo spheroid cells possess progenitor cell traits that are probably attained through corruption of "stemness-" associated transcription factor networks. Furthermore, trophoblastic cells are highly prone to unspecific binding, which is resistant to conventional blocking methods, but which can be alleviated through blockage with human serum.

Criticality calculations of the HTR-10 pebble-bed reactor with SCALE6/CSAS6 and MCNP5

International Nuclear Information System (INIS)

Wang, Meng-Jen; Sheu, Rong-Jiun; Peir, Jinn-Jer; Liang, Jenq-Horng

2014-01-01

Highlights: • Comparisons of the HTR-10 criticality calculations with SCALE6/CSAS6 and MCNP5 were performed. • The DOUBLEHET unit-cell treatment provides the best k eff estimation among PBR criticality calculations using SCALE6. • The continuous-energy SCALE6 calculations present a non-negligible discrepancy with MCNP5 in three PBR cases. - Abstract: HTR-10 is a 10 MWt prototype pebble-bed reactor (PBR) that presents a doubly heterogeneous geometry for neutronics calculations. An appropriate unit-cell treatment for the associated fuel elements is vital for creating problem-dependent multigroup cross sections. Considering four unit-cell options for resonance self-shielding correction in SCALE6, a series of HTR-10 core models were established using the CSAS6 sequence to systematically investigate how they affected the computational accuracy and efficiency of PBR criticality calculations. Three core configurations, which ranged from simplified infinite lattices to a detailed geometry, were examined. Based on the same ENDF/B-VII.0 cross-section library, multigroup results were evaluated by comparing with continuous-energy SCALE6/CSAS6 and MCNP5 calculations. The comparison indicated that the INFHOMMEDIUM results overestimated the effective multiplication factor (k eff ) by about 2800 pcm, whereas the LATTICECELL and MULTIREGION treatments overestimated k eff values with similar biases at approximately 470–680 pcm. The DOUBLEHET results attained further improvement, reducing the k eff overestimation to approximately 280 pcm. The comparison yielded two unexpected problems from using SCALE6/CSAS6 in HTR-10 criticality calculations. In particular, the continuous-energy CSAS6 calculations in this study present a non-negligible discrepancy with MCNP5, potentially causing a k eff value overestimate of approximately 680 pcm. Notably, using a cell-weighted mixture instead of an explicit model of individual TRISO particles in the pebble fuel zone does not shorten the

Intercomparison of rod-worth measurement techniques in a LEU-HTR assembly

International Nuclear Information System (INIS)

Williams, T.; Chawla, R.

1994-01-01

The measurement of absorber-rod worths in the radial reflector of a LEU-HTR pebble bed system is described. Particular emphasis is placed on the choice of complementary measurement techniques to ensure that sensitivities to systematic errors in the calculated parameters used in the analysis are minimised. (author) 3 figs., 3 tabs., 8 refs

The improvement of the method of equivalent cross section in HTR

International Nuclear Information System (INIS)

Guo, J.; Li, F.

2012-01-01

The Method of Equivalence Cross-Sections (MECS) is a combined transport-diffusion method. By appropriately adjusting the diffusion coefficient of homogenized absorber region, the diffusion theory could yield satisfactory results for the full core model with strong neutron absorber material, for example the control rod in High temperature gas cooled reactor (HTR). Original implementation of MECS based on 1-D cell transport model has some limitation on accuracy and applicability, a new implementation of MECS based on 2-D transport model are proposed and tested in this paper. This improvement can extend the MECS to the calculation of twin small absorber ball system which have a non-circular boring in graphite reflector and different radial position. A least-square algorithm for the calculation of equivalent diffusion coefficient is adopted, and special treatment for diffusion coefficient for higher energy group is proposed in the case that absorber is absent. Numerical results to adopt MECS into control rod calculation in HTR are encouraging. However, there are some problems left. (authors)

Prediction calculation of HTR-10 fuel loading for the first criticality

International Nuclear Information System (INIS)

Jing Xingqing; Yang Yongwei; Gu Yuxiang; Shan Wenzhi

2001-01-01

The 10 MW high temperature gas cooled reactor (HTR-10) was built at Institute of Nuclear Energy Technology, Tsinghua University, and the first criticality was attained in Dec. 2000. The high temperature gas cooled reactor physics simulation code VSOP was used for the prediction of the fuel loading for HTR-10 first criticality. The number of fuel element and graphite element was predicted to provide reference for the first criticality experiment. The prediction calculations toke into account the factors including the double heterogeneity of the fuel element, buckling feedback for the spectrum calculation, the effect of the mixture of the graphite and the fuel element, and the correction of the diffusion coefficients near the upper cavity based on the transport theory. The effects of impurities in the fuel and the graphite element in the core and those in the reflector graphite on the reactivity of the reactor were considered in detail. The first criticality experiment showed that the predicted values and the experiment results were in good agreement with little relative error less than 1%, which means the prediction was successful

Random geometry capability in RMC code for explicit analysis of polytype particle/pebble and applications to HTR-10 benchmark

International Nuclear Information System (INIS)

Liu, Shichang; Li, Zeguang; Wang, Kan; Cheng, Quan; She, Ding

2018-01-01

Highlights: •A new random geometry was developed in RMC for mixed and polytype particle/pebble. •This capability was applied to the full core calculations of HTR-10 benchmark. •Reactivity, temperature coefficient and control rod worth of HTR-10 were compared. •This method can explicitly model different packing fraction of different pebbles. •Monte Carlo code with this method can simulate polytype particle/pebble type reactor. -- Abstract: With the increasing demands of high fidelity neutronics analysis and the development of computer technology, Monte Carlo method is becoming more and more attractive in accurate simulation of pebble bed High Temperature gas-cooled Reactor (HTR), owing to its advantages of the flexible geometry modeling and the use of continuous-energy nuclear cross sections. For the double-heterogeneous geometry of pebble bed, traditional Monte Carlo codes can treat it by explicit geometry description. However, packing methods such as Random Sequential Addition (RSA) can only produce a sphere packing up to 38% volume packing fraction, while Discrete Element Method (DEM) is troublesome and also time consuming. Moreover, traditional Monte Carlo codes are difficult and inconvenient to simulate the mixed and polytype particles or pebbles. A new random geometry method was developed in Monte Carlo code RMC to simulate the particle transport in polytype particle/pebble in double heterogeneous geometry systems. This method was verified by some test cases, and applied to the full core calculations of HTR-10 benchmark. The reactivity, temperature coefficient and control rod worth of HTR-10 were compared for full core and initial core in helium and air atmosphere respectively, and the results agree well with the benchmark results and experimental results. This work would provide an efficient tool for the innovative design of pebble bed, prism HTRs and molten salt reactors with polytype particles or pebbles using Monte Carlo method.

A subroutine for the calculation of resonance cross sections of U-238 in HTR fuel elements

Energy Technology Data Exchange (ETDEWEB)

Cuniberti, R; Marullo, G C

1971-02-15

In this paper, a survey of the codes used at Ispra for the calculations of resonance absorption in HTR fuel elements is presented and a subroutine for the calculation of resonance cross-sections, in a seven groups energy structure, for a HTR lattice of annular type is described. A library of homogeneous resonance integrals and a wide tabulation of lump and kernel Bell factors, and moderators efficiency is given. This paper deals mainly with the problem of taking into account the correct slowing down of neutrons in the graphite and with the derivation of Bell factors to be used in a multigroup calculation scheme.

Studies on equilibrium fuel management schemes on the Dragon HTR core design

Energy Technology Data Exchange (ETDEWEB)

Daub, J; Pedersen, J

1971-02-03

The Dragon Project has recently started investigations on fuel management in HTR's with the assumed Dragon design. The study covers the results of investigations into a number of equilibrium fuel management schemes with the 1-dimensional FLATTER code and calculations of the corresponding total power generating costs with the programme TECO.

Post-irradiation examination of HTR-fuel at the Austrian Research Centre Seibersdorf Ltd

International Nuclear Information System (INIS)

Reitsamer, G.; Proksch, E.; Stolba, G.; Strigl, A.; Falta, G.; Zeger, J.

1985-01-01

Austrian R and D activities in the HTR-field reach back almost to the beginning of this advanced reactor line. For more than 20 years post-irradiation examination (PIE) of HTR-fuel has been performed at the laboratories of the Austrian Research Centre Seibersdorf Ltd. (OEFZS) (formerly OESGAE) and a high degree of qualification has been achieved in the course of that time. Most of the PIE-work has been carried out by international cooperation on contract basis with the OECD-DRAGON-project and with KFA-Juelich (FRG). There has also been some collaboration with GA (USA), Belgonucleaire and others in the past. HTR-fuel elements contain the fissile and fertile materials in form of coated particles (CPs) which are embedded in a graphite matrix. Because of this special design it has been necessary from the very beginning of the PIE work up to now to develop new methods (i.e. fuel element disintegration methods, chlorine gas leach, single particle examination techniques...) as well as to adapt and improve already existing methods (i.e. gamma spectrometry, mass-spectrometry, optical methods...). The main interests on PIE-work at Seibersdorf are concentrated on particle performance, fission product distribution and the 'free' Uranium content (contamination and broken particles) of the fuel elements (fuel spheres or cylindrical compacts). A short compilation of the applied methods and of available instrumental facilities is given as follows: deconsolidation of fuel elements; equipment for electrochemical deconsolidation; examinations and measurements of graphite and electrolyte samples; examination of coated particles; single particle examinations

Utilization of heat from High Temperature Reactors (HTR) for dry reforming of methane

Science.gov (United States)

Jastrząb, Krzysztof

2018-01-01

One of the methods for utilization of waste carbon dioxide consists in reaction of methane with carbon dioxide, referred to as dry reforming of methane. It is an intensely endothermic catalytic process that takes place at the temperature above 700°C. Reaction of methane with carbon dioxide leads to formation of synthesis gas (syngas) that is a valuable chemical raw material. The energy that is necessary for the process to take place can be sourced from High Temperature Nuclear Reactors (HTR). The completed studies comprises a series of thermodynamic calculations and made it possible to establish optimum conditions for the process and demand for energy from HTR units. The dry reforming of methane needs also a catalytic agent with appropriate activity, therefore the hydrotalcite catalyser with admixture of cerium and nickel, developed at AGH University of Technology seems to be a promising solution. Thus, the researchers from the Institute for Chemical Processing of Coal (IChPW) in Zabrze have developed a methodology for production of the powdery hydrotalcite catalyser and investigated catalytic properties of the granulate obtained. The completed experiments confirmed that the new catalyser demonstrated high activity and is suitable for the process of methane dry reforming. In addition, optimum parameters of the were process (800°C, CO2:CH4 = 3:1) were established as well. Implementation of the technology in question into industrial practice, combined with utilization of HTR heat can be a promising method for management of waste carbon dioxide and may eventually lead to mitigation of the greenhouse effect.

Post-irradiation examination of HTR-fuel at the Austrian Research Centre Seibersdorf Ltd

Energy Technology Data Exchange (ETDEWEB)

Reitsamer, G; Proksch, E; Stolba, G; Strigl, A; Falta, G; Zeger, J [Department of Chemistry, Austrian Research Centre Seibersdorf Ltd., Seibersdorf (Austria)

1985-07-01

Austrian R and D activities in the HTR-field reach back almost to the beginning of this advanced reactor line. For more than 20 years post-irradiation examination (PIE) of HTR-fuel has been performed at the laboratories of the Austrian Research Centre Seibersdorf Ltd. (OEFZS) (formerly OESGAE) and a high degree of qualification has been achieved in the course of that time. Most of the PIE-work has been carried out by international cooperation on contract basis with the OECD-DRAGON-project and with KFA-Juelich (FRG). There has also been some collaboration with GA (USA), Belgonucleaire and others in the past. HTR-fuel elements contain the fissile and fertile materials in form of coated particles (CPs) which are embedded in a graphite matrix. Because of this special design it has been necessary from the very beginning of the PIE work up to now to develop new methods (i.e., fuel element disintegration methods, chlorine gas leach, single particle examination techniques...) as well as to adapt and improve already existing methods (i.e. gamma spectrometry, mass-spectrometry, optical methods...). The main interests on PIE-work at Seibersdorf are concentrated on particle performance, fission product distribution and the 'free' Uranium content (contamination and broken particles) of the fuel elements (fuel spheres or cylindrical compacts). A short compilation of the applied methods and of available instrumental facilities is given as follows: deconsolidation of fuel elements; equipment for electrochemical deconsolidation; examinations and measurements of graphite and electrolyte samples; examination of coated particles; single particle examinations.

HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power--an intermediate phenotype for alcoholism and co-morbid behaviors.

Science.gov (United States)

Ducci, Francesca; Enoch, Mary-Anne; Yuan, Qiaoping; Shen, Pei-Hong; White, Kenneth V; Hodgkinson, Colin; Albaugh, Bernard; Virkkunen, Matti; Goldman, David

2009-02-01

Alcohol use disorders (AUD) with co-morbid antisocial personality disorder (ASPD) have been associated with serotonin (5-HT) dysfunction. 5-HT3 receptors are potentiated by ethanol and appear to modulate reward. 5-HT3 receptor antagonists may be useful in the treatment of early-onset alcoholics with co-morbid ASPD. Low-voltage alpha electroencephalogram (EEG) power, a highly heritable trait, has been associated with both AUD and ASPD. A recent whole genome linkage scan in one of our samples, Plains American Indians (PI), has shown a suggestive linkage peak for alpha power at the 5-HT3R locus. We tested whether genetic variation within the HTR3A and HTR3B genes influences vulnerability to AUD with comorbid ASPD (AUD+ASPD) and moderates alpha power. Our study included three samples: 284 criminal alcoholic Finnish Caucasians and 234 controls; two independent community-ascertained samples with resting EEG recordings: a predominantly Caucasian sample of 191 individuals (Bethesda) and 306 PI. In the Finns, an intronic HTR3B SNP rs3782025 was associated with AUD+ASPD (P=.004). In the Bethesda sample, the same allele predicted lower alpha power (P=7.37e(-5)). Associations between alpha power and two other HTR3B SNPs were also observed among PI (P=.03). One haplotype in the haplotype block at the 3' region of the gene that included rs3782025 was associated with AUD+ASPD in the Finns (P=.02) and with reduced alpha power in the Bethesda population (P=.00009). Another haplotype in this block was associated with alpha power among PI (P=.03). No associations were found for HTR3A. Genetic variation within HTR3B may influence vulnerability to develop AUD with comorbid ASPD. 5-HT3R might contribute to the imbalance between excitation and inhibition that characterize the brain of alcoholics.

A family-based association study of the HTR1B gene in eating disorders

Directory of Open Access Journals (Sweden)

Sandra Hernández

Full Text Available Objective: To explore the association of three polymorphisms of the serotonin receptor 1Dβ gene (HTR1B in the etiology of eating disorders and their relationship with clinical characteristics. Methods: We analyzed the G861C, A-161T, and A1180G polymorphisms of the HTR1B gene through a family-based association test (FBAT in 245 nuclear families. The sample was stratified into anorexia nervosa (AN spectrum and bulimia nervosa (BN spectrum. In addition, we performed a quantitative FBAT analysis of anxiety severity, depression severity, and Yale-Brown-Cornell Eating Disorders Scale (YBC-EDS in the AN and BN-spectrum groups. Results: FBAT analysis of the A-161T polymorphism found preferential transmission of allele A-161 in the overall sample. This association was stronger when the sample was stratified by spectrums, showing transmission disequilibrium between the A-161 allele and BN spectrum (z = 2.871, p = 0.004. Quantitative trait analysis showed an association between severity of anxiety symptoms and the C861 allele in AN-spectrum participants (z = 2.871, p = 0.004. We found no associations on analysis of depression severity or preoccupation and ritual scores in AN or BN-spectrum participants. Conclusions: Our preliminary findings suggest a role of the HTR1B gene in susceptibility to development of BN subtypes. Furthermore, this gene might have an impact on the severity of anxiety in AN-spectrum patients.

HTR8/SVneo Cells Display Trophoblast Progenitor Cell-Like Characteristics Indicative of Self-Renewal, Repopulation Activity, and Expression of “Stemness-” Associated Transcription Factors

Directory of Open Access Journals (Sweden)

Maja Weber

2013-01-01

Full Text Available Introduction. JEG3 is a choriocarcinoma—and HTR8/SVneo a transformed extravillous trophoblast—cell line often used to model the physiologically invasive extravillous trophoblast. Past studies suggest that these cell lines possess some stem or progenitor cell characteristics. Aim was to study whether these cells fulfill minimum criteria used to identify stem-like (progenitor cells. In summary, we found that the expression profile of HTR8/SVneo (CDX2+, NOTCH1+, SOX2+, NANOG+, and OCT- is distinct from JEG3 (CDX2+ and NOTCH1+ as seen only in human-serum blocked immunocytochemistry. This correlates with HTR8/SVneo’s self-renewal capacities, as made visible via spheroid formation and multi-passagability in hanging drops protocols paralleling those used to maintain embryoid bodies. JEG3 displayed only low propensity to form and reform spheroids. HTR8/SVneo spheroids migrated to cover and seemingly repopulate human chorionic villi during confrontation cultures with placental explants in hanging drops. We conclude that HTR8/SVneo spheroid cells possess progenitor cell traits that are probably attained through corruption of “stemness-” associated transcription factor networks. Furthermore, trophoblastic cells are highly prone to unspecific binding, which is resistant to conventional blocking methods, but which can be alleviated through blockage with human serum.

Testing of HTR UO{sub 2} TRISO fuels in AVR and in material test reactors

Energy Technology Data Exchange (ETDEWEB)

Kania, Michael J., E-mail: MichaelJKania@googlemail.com [Retired from Lockheed Martin Corp, 20 Beach Road, Averill Park, NY 12018 (United States); Nabielek, Heinz, E-mail: heinznabielek@me.com [Retired from Research Center Jülich, Monschauerstrasse 61, 52355 Düren (Germany); Verfondern, Karl [Research Center Juelich,Research Center Jülich, Institute of Energy and Climate Research, 52425 Jülich (Germany); Allelein, Hans-Josef [Research Center Juelich,Research Center Jülich, Institute of Energy and Climate Research, 52425 Jülich (Germany); RWTH Aachen, 52072 Aachen (Germany)

2013-10-15

The German High Temperature Reactor Fuel Development Program successfully developed, licensed and manufactured many thousands of spherical fuel elements that were used to power the experimental AVR reactor and the commercial THTR reactor. In the 1970s, this program extended the performance envelope of HTR fuels by developing and qualifying the TRISO-coated particle system. Irradiation testing in real-time AVR tests and accelerated MTR tests demonstrated the superior manufacturing process of this fuel and its irradiation performance. In the 1980s, another program direction change was made to a low enriched UO{sub 2} TRISO-coated particle system coupled with high-quality manufacturing specifications designed to meet new HTR plant design needs. These needs included requirements for inherent safety under normal operation and accident conditions. Again, the German fuel development program met and exceeded these challenges by manufacturing and qualifying the low-enriched UO{sub 2} TRISO-fuel system for HTR systems with steam generation, gas-turbine systems and very high temperature process heat applications. Fuel elements were manufactured in production scale facilities that contained near defect free UO{sub 2} TRISO coated particles, homogeneously distributed within a graphite matrix with very low levels of uranium contamination. Good irradiation performance for these elements was demonstrated under normal operating conditions to 12% FIMA and under accident conditions not exceeding 1600 °C.

Performance limits of coated particle fuel. Part III. Fission product migration in HTR fuel

Energy Technology Data Exchange (ETDEWEB)

Nabielek, H.; Hick, H.; Wagner-Loffler, M.; Voice, E. H.

1974-06-15

A general introduction and literature survey to the physics and mathematics of fission product migration in HTR fuel is given as well as a review of available experimental results and their evaluation in terms of models and materials data.

The market potential of HTR modular reactors as a heat source for high - temperature processes in the Federal Republic of Germany

International Nuclear Information System (INIS)

1988-01-01

The HTR is the only reactor system which can provide process heat in a wide temperature range up to 950 0 C. The HTR module is designed as an unsophisticated, safe and universal heat source with a large field of applications. The following applications have been considered: the steam reforming of natural gas and coal conversion processes for the production of methanol, hydrogen and SNG. They are investigated in many different modifications and nuclear and autothermal processes are compared. Other applications of nuclear process heat in the chemical and petrochemical industry seem to be appropriate and promising, but could not be analysed because of lack of data. The economic results show that for today's coal and gas processing the HTR can only compete against conventional conversion processes for specific premises. Especially, those processses in which valuable fossil fuels such as natural gas are substituted by nuclear process heat promise an economic bebefit. Looking to the market of the year 2030 and the need for process heat in the chemical and steel industries (including the demand for synthesis gas), cement and refinery industries, for the production of aluminium oxide and for tertiary oil recovery, a total theoretical market in the Federal Republic of Germany of up to 60 HTR-2 module plants is estimated

Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1.

Science.gov (United States)

Jacobo, Sarah Melissa P; Deangelis, Margaret M; Kim, Ivana K; Kazlauskas, Andrius

2013-05-01

Synonymous single nucleotide polymorphisms (SNPs) within a transcript's coding region produce no change in the amino acid sequence of the protein product and are therefore intuitively assumed to have a neutral effect on protein function. We report that two common variants of high-temperature requirement A1 (HTRA1) that increase the inherited risk of neovascular age-related macular degeneration (NvAMD) harbor synonymous SNPs within exon 1 of HTRA1 that convert common codons for Ala34 and Gly36 to less frequently used codons. The frequent-to-rare codon conversion reduced the mRNA translation rate and appeared to compromise HtrA1's conformation and function. The protein product generated from the SNP-containing cDNA displayed enhanced susceptibility to proteolysis and a reduced affinity for an anti-HtrA1 antibody. The NvAMD-associated synonymous polymorphisms lie within HtrA1's putative insulin-like growth factor 1 (IGF-1) binding domain. They reduced HtrA1's abilities to associate with IGF-1 and to ameliorate IGF-1-stimulated signaling events and cellular responses. These observations highlight the relevance of synonymous codon usage to protein function and implicate homeostatic protein quality control mechanisms that may go awry in NvAMD.

Le projet SCORE (Superior cold recycling) : Evaluation en laboratoire des proprietes mécaniques des enrobés bitumineux retraités en place par les techniques à froid

OpenAIRE

BROSSEAUD, Y; GAUDEFROY, V; BEGHIN, A; PLACIN, F; DELFOSSE, F; BAENA, JM

2006-01-01

Afin de promouvoir les technologies de construction favorables à l'environnement (Environmentally Friendly Construction Technologies - EFCT) et pour son 5è programme cadre de recherche et développement PCRD, la Commission européenne a décidé de financer un projet de recherche sur le retraitement en place à froid, intitulé SCORE "Superior Cold Recycling based on benefits of bituminous microemulsions and foamed bitumen. A EFCT system for the rehabilitation and the maintenance of roads", et visa...

Potential Applications for Nuclear Energy besides Electricity Generation: AREVA Global Perspective of HTR Potential Market

International Nuclear Information System (INIS)

Soutworth, Finis; Gauthier, Jean-Claude; Lecomte, Michel; Carre, Franck

2007-01-01

Energy supply is increasingly showing up as a major issue for electricity supply, transportation, settlement, and process heat industrial supply including hydrogen production. Nuclear power is part of the solution. For electricity supply, as exemplified in Finland and France, the EPR brings an immediate answer; HTR could bring another solution in some specific cases. For other supply, mostly heat, the HTR brings a solution inaccessible to conventional nuclear power plants for very high or even high temperature. As fossil fuels costs increase and efforts to avoid generation of Greenhouse gases are implemented, a market for nuclear generated process heat will develop. Following active developments in the 80's, HTR have been put on the back burner up to 5 years ago. Light water reactors are widely dominating the nuclear production field today. However, interest in the HTR technology was renewed in the past few years. Several commercial projects are actively promoted, most of them aiming at electricity production. ANTARES is today AREVA's response to the cogeneration market. It distinguishes itself from other concepts with its indirect cycle design powering a combined cycle power plant. Several reasons support this design choice, one of the most important of which is the design flexibility to adapt readily to combined heat and power applications. From the start, AREVA made the choice of such flexibility with the belief that the HTR market is not so much in competition with LWR in the sole electricity market but in the specific added value market of cogeneration and process heat. In view of the volatility of the costs of fossil fuels, AREVA's choice brings to the large industrial heat applications the fuel cost predictability of nuclear fuel with the efficiency of a high temperature heat source free of greenhouse gases emissions. The ANTARES module produces 600 MWth which can be split into the required process heat, the remaining power drives an adapted prorated

The development on-line monitoring system of active magnetic bearings for HTR-10GT

International Nuclear Information System (INIS)

Shi Zhengang; Shi Lei; Zha Meisheng; Yu Suyuan

2005-01-01

High Temperature Gas-cooled Reactor (HTR) is recognized as an advanced type of reactor incorporating many design enhancements such as inherent safety features, fuel cycle flexibility, highly fuel utilization, highly efficient electricity generation and process heat application. The research and development of HTR started at the middle of the 1970's, and came to be a part of the Chinese High Technology Program in 1986. A plan to build a 10 MW High Temperature Gas-cooled Reactor (HTR-10) was approved by the State Science and Technology Commission in 1990, and in 1995 the construction was initiated at the Institute of Nuclear Energy Technology (INET), Tsinghua University. The full power 10 MW operation for 72 hours have reached in 2003, and have been checked and accepted by the State Science and Technology Commission. In order to advance the HTR-10 performance, the project of the Helium Gas Turbine Generator for the HTR-10 was authorized by the State Science and Technology Commission, and stared in 2003. In this project, active magnetic bearings (AMBs) are chosen to support the generator rotor and the turbocompressor rotor in the power conversion unit because of their numerous advantages over the conventional bearings. In order to detect how the AMB system works in operation and make diagnosis whether the system behaves normally or not, the monitoring system based on the virtual instruments is designed to monitor the working conditions of the PCU, and to ensure its normal operation. This monitoring system consists of the industry personal computer (PC), the data acquisition system, the measurement transmitters and the LabVIEW system platform. It is located at the PCU control room, and communicates with the master control room by Controller Area Net (CAN). The development is divided into the following three steps: First, a data acquisition platform to collect and acquire all the necessary and useful data from the operation of the AMB system is developed. Second, the

Post-irradiation examination of HTR-fuel at the Austrian Research Centre Seibersdorf Ltd

International Nuclear Information System (INIS)

Reitsamer, G.; Proksch, E.; Stolba, G.; Strigl, A.; Falta, G.; Zeger, J.

1984-02-01

This paper describes methods and measurements developed at the Austrian Research Centre Seibersdorf for the evaluation of the irradiation performance of HTR fuel. Main interest is concentrated on particle failure rates, fission product release, burn-up and inventory measurements (solid and gaseous fission products, uranium inventory). (Author) [de

Neutronic feasibility design of a small long-life HTR

International Nuclear Information System (INIS)

Ding Ming; Kloosterman, Jan Leen

2011-01-01

Highlights: ► We propose the neutronic feasibility design of a small, long lifetime and transportable HTR. ► Comparison of cylindrical, annular and scatter cores of the small block-type HTR. ► The design of the scatter core effectively reduces the number of the fuel block and increases the lifetime and burnup of the reactor. - Abstract: Small high temperature gas-cooled reactors (HTRs) have the advantages of transportability, modular construction and flexible site selection. This paper presents the neutronic feasibility design of a 20 MWth U-Battery, which is a long-life block-type HTR. Key design parameters and possible reactor core configurations of the U-Battery were investigated by SCALE 5.1. The design parameters analyzed include fuel enrichment, the packing fraction of TRISO particles, the radii of fuel compacts and kernels, and the thicknesses of top and bottom reflectors. Possible reactor core configurations investigated include five cylindrical, two annular and four scatter reactor cores for the U-Battery. The neutronic design shows that the 20 MWth U-Battery with a 10-year lifetime is feasible using less than 20% enriched uranium, while the negative values of the temperature coefficients of reactivity partly ensure the inherent safety of the U-Battery. The higher the fuel enrichment and the packing fraction of TRISO particles are, the lower the reactivity swing during 10 years will be. There is an optimum radius of fuel kernels for each value of the fuel compact design parameter (i.e., radius) and a specific fuel lifetime. Moreover, the radius of fuel kernels has a small influence on the infinite multiplication factor of a typical fuel block in the range of 0.2–0.25 mm, when the radius of fuel compacts is 0.6225 cm and the lifetime of the fuel block is 10 years. The comparison of the cylindrical reactor cores with the non-cylindrical ones shows that neutron under-moderation is a basic neutronic characteristic of the reactor core of the U

Study of liquid hydrogen and liquid deuterium cold neutron sources; Etude de sources de neutrons froids a hydrogene et deuterium liquides

Energy Technology Data Exchange (ETDEWEB)

Harig, H D [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1967-12-01

In view of the plant of the cold neutron source for a high flux reactor (maximal thermal flux of about 10{sup 15} n/cm{sup 2}s) an experimental study of several cold sources of liquid hydrogen and liquid deuterium has been made in a low power reactor (100 kW, about 10{sup 12} n/cm{sup 2}s). We have investigated: -cold neutron sources of liquid hydrogen shaped as annular layers of different thickness. Normal liquid hydrogen was used as well as hydrogen with a high para-percentage. -Cold neutron sources of liquid deuterium in cylinders of 18 and 38 cm diameter. In this case the sources could be placed into different positions to the reactor core within the heavy water reflector. This report gives a general description of the experimental device and deals more detailed with the design of the cryogenic systems. Then, the measured results are communicated, interpreted and finally compared with those of a theoretical study about the same cold moderators which have been the matter of the experimental investigation. (authors) [French] En vue de l'installation d'une source a neutrons froids dans un reacteur a haut flux (flux thermique maximal environ 10{sup 15} n/cm{sup 2}s), nous avons fait une etude neutronique experimentale de differentes sources froides a hydrogene et a deuterium liquides aupres d'un reacteur a faible puissance (100 kW environ 10{sup 12} n/cm{sup 2}s). Nous avons etudie: des couches annulaires de differentes epaisseurs d'hydrogene liquide normal et d'hydrogene a grand pourcentage para, des cellules cylindriques de 18 et 38 cm de diametre, remplies de deuterium liquide et placees a differentes positions dans le reflecteur D{sub 2}O. Ce travail traite l'implantation de l'installation cryogenique et donne une description generale de l'experience. L'interpretation des resultats fait etat entre autres d'une comparaison entre l'experience et une etude theorique portant sur les memes moderateurs. (auteurs)

CEA and AREVA R and D on V/HTR fuel fabrication with the CAPRI experimental manufacturing line

International Nuclear Information System (INIS)

Charollais, Francois; Fonquernie, Sophie; Perrais, Christophe; Perez, Marc; Cellier, Francois; Vitali, Marie-Pierre

2006-01-01

In the framework of the French V/HTR fuel development and qualification program, the Commissariat a l'Energie Atomique (CEA) and AREVA through its program called ANTARES (Areva New Technology for Advanced Reactor Energy Supply) conduct R and D projects covering the mastering of UO 2 coated particle and fuel compact fabrication technology. To fulfill this task, a review of past knowledge, of existing technologies and a preliminary laboratory scale work program have been conducted with the aim of retrieving the know-how on HTR coated particle and compact manufacture: - The different stages of UO 2 kernel fabrication GSP Sol-Gel process have been reviewed, reproduced and improved; - The experimental conditions for the chemical vapour deposition (CVD) of coatings have been defined on dummy kernels and development of innovative characterization methods has been carried out; - Former CERCA compacting process has been reviewed and updated. In parallel, an experimental manufacturing line for coated particles, named GAIA, and a compacting line based on former CERCA compacting experience have been designed, constructed and are in operation since early 2005 at CEA Cadarache and CERCA Romans, respectively. These two facilities constitute the CAPRI line (CEA and AREVA PRoduction Integrated line). The major objectives of the CAPRI line are: - to recover and validate past knowledge; - to permit the optimisation of reference fabrication processes for kernels and coatings and the investigation of alternative and innovative fuel design (UCO kernel, ZrC coating); - to test alternative compact process options; - to fabricate and characterize fuel required for irradiation and qualification purpose; - to specify needs for the fabrication of representative V/HTR TRISO fuel meeting industrial standards. This paper presents the progress status of the R and D conducted on V/HTR fuel particle and compact manufacture by mid 2005. (authors)

Results of a European industrial heat market analysis as a pre-requisite to evaluating the HTR market in Europe and elsewhere

International Nuclear Information System (INIS)

Bredimas, Alexandre

2014-01-01

High temperature nuclear reactors will mainly address the market of industrial cogeneration. This market is a part of the overall market of the heat concretely consumed by industry, in particular heat intensive industries. In simpler terms, the HTR market is a part of the industrial cogeneration market, which itself is a part of the industrial heat market. The EU-supported project EUROPAIRS (2009–2011) has therefore carried out a comprehensive study of the complete European industrial heat market in order to prepare for the deployment of HTRs. This information did not exist priori to the study. The purposes of this paper are (1) to present the methodology of the study and the experience gathered in order to exchange with non-European equivalent or future initiatives (beyond the discussions already engaged with the US), (2) to synthesise the quantitative results of the study and (3) to briefly report on the cogeneration usages in several key industries (e.g. chemicals, refining, steelmaking…) which may affect HTR designing. The paper finishes with some reflection on the part of the heat market that HTRs could potentially address. In correlation with our other paper on the pre-economic analysis, this paper intend to pave the way for an international cooperation on evaluating the market for HTR worldwide, which is an information of common interest to the HTR community

Standard and chances of the HTR in the Federal Republic of Germany

International Nuclear Information System (INIS)

Simon, M.; Harder, H.

1980-01-01

If one believes the verbal support of the politicians on the High-Temperature Reactor this reactor type seems to have a good future. The facts show that inspite of the well known properties of the HTR and the engagement of the industry and potential operators, progress is hardly made. Soon it could be too late for this reactor line. (orig.) [de

Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin

LENUS (Irish Health Repository)

Boehm, Manja

2012-04-25

AbstractBackgroundCampylobacter jejuni is one of the most important bacterial pathogens causing food-borne illness worldwide. Crossing the intestinal epithelial barrier and host cell entry by C. jejuni is considered the primary reason of damage to the intestinal tissue, but the molecular mechanisms as well as major bacterial and host cell factors involved in this process are still widely unclear.ResultsIn the present study, we characterized the serine protease HtrA (high-temperature requirement A) of C. jejuni as a secreted virulence factor with important proteolytic functions. Infection studies and in vitro cleavage assays showed that C. jejuni’s HtrA triggers shedding of the extracellular E-cadherin NTF domain (90 kDa) of non-polarised INT-407 and polarized MKN-28 epithelial cells, but fibronectin was not cleaved as seen for H. pylori’s HtrA. Deletion of the htrA gene in C. jejuni or expression of a protease-deficient S197A point mutant did not lead to loss of flagella or reduced bacterial motility, but led to severe defects in E-cadherin cleavage and transmigration of the bacteria across polarized MKN-28 cell layers. Unlike other highly invasive pathogens, transmigration across polarized cells by wild-type C. jejuni is highly efficient and is achieved within a few minutes of infection. Interestingly, E-cadherin cleavage by C. jejuni occurs in a limited fashion and transmigration required the intact flagella as well as HtrA protease activity, but does not reduce transepithelial electrical resistance (TER) as seen with Salmonella, Shigella, Listeria or Neisseria.ConclusionThese results suggest that HtrA-mediated E-cadherin cleavage is involved in rapid crossing of the epithelial barrier by C. jejuni via a very specific mechanism using the paracellular route to reach basolateral surfaces, but does not cleave the fibronectin receptor which is necessary for cell entry.

Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin.

Science.gov (United States)

Boehm, Manja; Hoy, Benjamin; Rohde, Manfred; Tegtmeyer, Nicole; Bæk, Kristoffer T; Oyarzabal, Omar A; Brøndsted, Lone; Wessler, Silja; Backert, Steffen

2012-04-25

Campylobacter jejuni is one of the most important bacterial pathogens causing food-borne illness worldwide. Crossing the intestinal epithelial barrier and host cell entry by C. jejuni is considered the primary reason of damage to the intestinal tissue, but the molecular mechanisms as well as major bacterial and host cell factors involved in this process are still widely unclear. In the present study, we characterized the serine protease HtrA (high-temperature requirement A) of C. jejuni as a secreted virulence factor with important proteolytic functions. Infection studies and in vitro cleavage assays showed that C. jejuni's HtrA triggers shedding of the extracellular E-cadherin NTF domain (90 kDa) of non-polarised INT-407 and polarized MKN-28 epithelial cells, but fibronectin was not cleaved as seen for H. pylori's HtrA. Deletion of the htrA gene in C. jejuni or expression of a protease-deficient S197A point mutant did not lead to loss of flagella or reduced bacterial motility, but led to severe defects in E-cadherin cleavage and transmigration of the bacteria across polarized MKN-28 cell layers. Unlike other highly invasive pathogens, transmigration across polarized cells by wild-type C. jejuni is highly efficient and is achieved within a few minutes of infection. Interestingly, E-cadherin cleavage by C. jejuni occurs in a limited fashion and transmigration required the intact flagella as well as HtrA protease activity, but does not reduce transepithelial electrical resistance (TER) as seen with Salmonella, Shigella, Listeria or Neisseria. These results suggest that HtrA-mediated E-cadherin cleavage is involved in rapid crossing of the epithelial barrier by C. jejuni via a very specific mechanism using the paracellular route to reach basolateral surfaces, but does not cleave the fibronectin receptor which is necessary for cell entry.

Safety related studies on the accident behaviour of the HTR-100

International Nuclear Information System (INIS)

Wolters, J.; Mertens, J.; Altes, J.; Bongartz, R.; Breitbach, G.; David, P.H.; Degen, G.; Ehrlich, H.G.; Escherich, K.H.; Frank, E.; Hennings, W.; Jahn, W.; Koschmieder, R.; Marx, J.; Meister, G.; Moormann, R.; Rehm, W.; Verfondern, K.

1991-10-01

The aim of investigations was to verify the safety concept of the plant for balance and to quantify the radiological risk to be expected in operating an HTR-100 double unit system. Moreover, aspects of the investment risk were considered. The spectrum of initiating events ranged from so-called transients to leaks in the primary circuit and steam generator and even included earthquakes. Some of the event trees derived were highly complex and extensive due to the situation of the steam generator above the core and with regard to the double unit plant concept with increased possibilities of accident control, but also with respect to potential accident propagation. Correspondingly sophisticated analyses were required to identify risk-relevant event sequences. Environmental exposure for all risk-relevant accidents is so low that accident consequence calculations do not reveal any lethal radiation doses and practically no stochastic fatal injuries. These calculations neither assumed acute protective measures nor long-term resettlement or decontamination. The radiological risk caused by an HTR-100 plant is therefore to be classified as very low. The initiating events selected as representative and the event sequences studied in detail cover the risk-relevant event spectrum well into the hypothetical range. (orig./HP) [de

Conception of a modular HTR-process heat facility with optimization of the pressure level

International Nuclear Information System (INIS)

Bousack, H.

1984-11-01

The operation of a steam reformer heated by nuclear power with a process pressure of about 20 bar provides advantages with respect to process engineering due to the improved conversion and simplified product gas treatment for the follow-on process. The effects of a reduction in pressure on the components of the primary circuit in a modular HTR facility, as well as various process engineering possibilities for producing methanol in the follow-on process are discussed in this paper. Studies cover the influence of core geometry and power density, as well as possibilities of increasing the modular power at a maximum accident temperature of 1600 0 C. An inherently functioning area cooling system is proposed for afterheat removal outside the primary circuit. Based on the optimized pressure, a modular HTR process heat facility is conceived to produce methanol from natural gas and carbon dioxide basically satisfying the requirement of zero emission. (orig.) [de

Coordinated Control Design for the HTR-PM Plant: From Theoretic Analysis to Simulation Verification

International Nuclear Information System (INIS)

Dong Zhe; Huang Xiaojin

2014-01-01

HTR-PM plant is a two-modular nuclear power plant based on pebble bed modular high temperature gas-cooled reactor (MHTGR), and adopts operation scheme of two nuclear steam supplying systems (NSSSs) driving one turbine. Here, an NSSS is composed of an MHTGR, a once-through steam generator (OTSG) and some connecting pipes. Due to the coupling effect induced by two NSSSs driving one common turbine and that between the MHTGR and OTSG given by common helium flow, it is necessary to design a coordinated control for the safe, stable and efficient operation of the HTR-PM plant. In this paper, the design of the feedback loops and control algorithms of the coordinated plant control law is firstly given. Then, the hardware-in-loop (HIL) system for verifying the feasibility and performance of this control strategy is introduced. Finally, some HIL simulation results are given, which preliminarily show that this coordinated control law can be implemented practically. (author)

From Rio to Johannesburg : The perspectives of NGO of the Reseau Action Climat

International Nuclear Information System (INIS)

Flipo, F.

2002-01-01

The Reseau Action Climat France (RCAF) (France Climate Action Network) was founded in 1996 with the goal of fighting against the risk of climatic change and to follow the implementation of sustainable development policies at the national level. The Climate Action Network (CAN), is comprised of in excess of 360 members from all five continents. A brief historical review of climatic change is provided, starting with the risk first being recognized at the end of the nineteenth century, through to the adoption of the Kyoto Protocol in 1997. Issues are discussed, ranging from the opinion of the general population in France that climatic change is unacceptable, and economic growth must be revised without the option of reverting to nuclear energy, to the belief that profound change in the development of industrialized nations is required. The long term positions of the RCAF are examined. They can be classified under the following headings: dispatching of damages and appropriateness of commitments of Parties with regard to the objective of the Convention, allocation of emissions quotas, links to sustainable development, and other perspectives. The author concludes by indicating that the situation form Rio to Johannesburg has deteriorated and that fighting against actual trends represents our best hope to mitigate climatic change. 24 refs., 2 figs

Development of Chinese HTR-PM pebble bed equivalent conductivity test facility

Energy Technology Data Exchange (ETDEWEB)

Ren, Cheng; Yang, Xingtuan; Jiang, Shengyao [Tsinghua Univ., Beijing (China). Inst. of Nuclear and New Energy Technology

2016-01-15

The first two 250-MWt high-temperature reactor pebble bed modules (HTR-PM) have been installing at the Shidaowan plant in Shandong Province, China. The values of the effective thermal conductivity of the pebble bed core are essential parameters for the design. For their determination, Tsinghua University in China has proposed a full-scale heat transfer experiment to conduct comprehensive thermal transfer tests in packed pebble bed and to determine the effective thermal conductivity.

Study on the shuffling scheme in HTR-10 MW test module

International Nuclear Information System (INIS)

Jing Xingqing; Zhang Xu; Luo Jingyu

1993-01-01

The shuffling ways, once through then out and multiple through then out, in HTR-10 MW Test Module are studied. Multiple through then out is better than once through with regard to rational use of the fuel and flattening the power. The behaviour of equilibrium core and loss of coolant accident is analyzed. The results indicate that characteristic features of the multiple through then out could be better to satisfy the demands of safety criterions

Relationship between the Toyo Tanso Group and HTR-PM

International Nuclear Information System (INIS)

Zhan Guobin; Konishi, Takashi

2014-01-01

IG-110 that is Isotropic graphite for nuclear applications, is the only product that is used for two types of High Temperature Gas-cooled Reactors, prismatic type HTTR and pebble-bed type HTR-10, that are currently in operation in the world. IG-110 is highly evaluated in the global market for its track record and physical stability. The Toyo Tanso Group won the contract to build graphite core internals for HTR-PM that is a world’s first modular pebble-bed high temperature gas-cooled demonstration reactor. A decision was made to manufacture IG-110 graphite materials at Toyo Tanso Japan called TTJ and to process products and undertake temporary assembly at Shanghai Toyo Tanso called STT. Manufacture of graphite materials for which TTJ is responsible has been completed. As the next step, processing of products is scheduled to commence at STT from this autumn. Our graphite materials were required to be 2,000 mm or more in maximum length. The number of graphite blocks required exceeded 3,500. Although the graphite structure requirements including configuration were highly challenging, we were able to meet all the requirements with our engineering capabilities, i.e. decades of track record in manufacture and stability in characteristics. STT that will start the machining process this autumn is equipped with state-of-the-art processing machines and three-dimensional measuring machines. Notably, STT has high levels of engineering capabilities to process and inspect tens of thousands of internal components for reactors in accordance with drawings and to temporarily assemble these components. (author)

A preliminary neutronic evaluation of the high temperature gas-cooled test reactor HTR-10 using the scale 6.0 code

International Nuclear Information System (INIS)

Sousa, Romulo V.; Fortini, Angela; Pereira, Claubia; Carvalho, Fernando R. de; Oliveira, Arno H.

2013-01-01

The High Temperature Gas-cooled Test Reactor HTR-10 is a 10 MW modular pebble bed type reactor, which core is filled with 27,000 spherical fuel elements, e.g. TRISO coated particles. This reactor was built by the Institute of Nuclear Energy Technology (INET), Tsinghua University, China, and its first criticality was attained on December 1, 2000. The main objectives of the HTR-10 are to verify and demonstrate the technical and safety features of the modular HTGR (High Temperature Gas-cooled Reactor) and to establish an experimental base for developing nuclear process heat applications. In this work, using the Standardized Computer Analysis for Licensing Evaluation (SCALE) 6.0, a nuclear code developed by Oak Ridge National Laboratory (ORNL), the HTR-10 first critical core is modeled by the DEN/UFMG. The K eff was obtained and compared with the reference value obtained by the Idaho National Laboratory. The result presents good agreement with experimental value. The goal is to validate the DEN/UFMG model to be applied in transmutation studies changing the fuel. (author)

Does the HTR module have a chance for the future?

International Nuclear Information System (INIS)

Steinwarz, W.

1989-01-01

The HTR module was developed as a robust and market-orientated heat source for a wide spectrum of applications. Its technology is largely based on that of the AVR. The choice of a low power density and the small core geometry permit thorough use to be made of the favourable safety characteristics and give an extra-ordinarily high degree of passive safety. There are possibilities for its introduction into the international market at present, particularly in the USSR and the People's Republic of China. (orig.)

GenHtr: a tool for comparative assessment of genetic heterogeneity in microbial genomes generated by massive short-read sequencing

Directory of Open Access Journals (Sweden)

Yu GongXin

2010-10-01

Full Text Available Abstract Background Microevolution is the study of short-term changes of alleles within a population and their effects on the phenotype of organisms. The result of the below-species-level evolution is heterogeneity, where populations consist of subpopulations with a large number of structural variations. Heterogeneity analysis is thus essential to our understanding of how selective and neutral forces shape bacterial populations over a short period of time. The Solexa Genome Analyzer, a next-generation sequencing platform, allows millions of short sequencing reads to be obtained with great accuracy, allowing for the ability to study the dynamics of the bacterial population at the whole genome level. The tool referred to as GenHtr was developed for genome-wide heterogeneity analysis. Results For particular bacterial strains, GenHtr relies on a set of Solexa short reads on given bacteria pathogens and their isogenic reference genome to identify heterogeneity sites, the chromosomal positions with multiple variants of genes in the bacterial population, and variations that occur in large gene families. GenHtr accomplishes this by building and comparatively analyzing genome-wide heterogeneity genotypes for both the newly sequenced genomes (using massive short-read sequencing and their isogenic reference (using simulated data. As proof of the concept, this approach was applied to SRX007711, the Solexa sequencing data for a newly sequenced Staphylococcus aureus subsp. USA300 cell line, and demonstrated that it could predict such multiple variants. They include multiple variants of genes critical in pathogenesis, e.g. genes encoding a LysR family transcriptional regulator, 23 S ribosomal RNA, and DNA mismatch repair protein MutS. The heterogeneity results in non-synonymous and nonsense mutations, leading to truncated proteins for both LysR and MutS. Conclusion GenHtr was developed for genome-wide heterogeneity analysis. Although it is much more time

Possibility of using gamma radiation from HTR reactors for the processing of food and medical products

International Nuclear Information System (INIS)

Pahladsingh, R.R.

2004-01-01

During the fission process in most of the presently operating nuclear reactors nuclear energy is converted into thermal energy and transferred to common steam cycles for power generation. As part of the fission process also α, β and neutrons particles are released from the nucleus; the release of gamma-rays is also a part of the fission process. In present nuclear reactors α, β, neutrons particles and particularly gamma-rays are not gainfully used as a result of the reactor design and of the containment. These plants are built as required by regulations and international standards for safety. The inherently safe HTR reactor, by its physics and design, does not need a special reinforced containment and it is worth looking into the possibilities of this design feature to use the by-products, such as Gamma-rays, from nuclear fission. In the HTR Pebble Bed Reactors the α, and β particles will remain in the kernels of the pebbles. This means that only the neutron particles and gamma-rays will be available outside the reactor pressure vessel. In this report a proposal is presented to use the gamma-rays of the HTR reactor for irradiation of food and agricultural produce. For neutron shielding a reflector is placed inside the reactor while outside the reactor neutron- and thermal-shielding will be accomplished with water. The high energy gamma-rays will pass through the water-shield and could be harnessed for radiation processing of food and medical products. (author)

HTR-PROTEUS pebble bed experimental program cores 9 & 10: columnar hexagonal point-on-point packing with a 1:1 moderator-to-fuel pebble ratio

Energy Technology Data Exchange (ETDEWEB)

Bess, John D. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2014-03-01

PROTEUS is a zero-power research reactor based on a cylindrical graphite annulus with a central cylindrical cavity. The graphite annulus remains basically the same for all experimental programs, but the contents of the central cavity are changed according to the type of reactor being investigated. Through most of its service history, PROTEUS has represented light-water reactors, but from 1992 to 1996 PROTEUS was configured as a pebble-bed reactor (PBR) critical facility and designated as HTR-PROTEUS. The nomenclature was used to indicate that this series consisted of High Temperature Reactor experiments performed in the PROTEUS assembly. During this period, seventeen critical configurations were assembled and various reactor physics experiments were conducted. These experiments included measurements of criticality, differential and integral control rod and safety rod worths, kinetics, reaction rates, water ingress effects, and small sample reactivity effects (Ref. 3). HTR-PROTEUS was constructed, and the experimental program was conducted, for the purpose of providing experimental benchmark data for assessment of reactor physics computer codes. Considerable effort was devoted to benchmark calculations as a part of the HTR-PROTEUS program. References 1 and 2 provide detailed data for use in constructing models for codes to be assessed. Reference 3 is a comprehensive summary of the HTR-PROTEUS experiments and the associated benchmark program. This document draws freely from these references. Only Cores 9 and 10 are evaluated in this benchmark report due to similarities in their construction. The other core configurations of the HTR-PROTEUS program are evaluated in their respective reports as outlined in Section 1.0. Cores 9 and 10 were evaluated and determined to be acceptable benchmark experiments.

HTR-PROTEUS PEBBLE BED EXPERIMENTAL PROGRAM CORES 9 & 10: COLUMNAR HEXAGONAL POINT-ON-POINT PACKING WITH A 1:1 MODERATOR-TO-FUEL PEBBLE RATIO

Energy Technology Data Exchange (ETDEWEB)

John D. Bess

2013-03-01

PROTEUS is a zero-power research reactor based on a cylindrical graphite annulus with a central cylindrical cavity. The graphite annulus remains basically the same for all experimental programs, but the contents of the central cavity are changed according to the type of reactor being investigated. Through most of its service history, PROTEUS has represented light-water reactors, but from 1992 to 1996 PROTEUS was configured as a pebble-bed reactor (PBR) critical facility and designated as HTR-PROTEUS. The nomenclature was used to indicate that this series consisted of High Temperature Reactor experiments performed in the PROTEUS assembly. During this period, seventeen critical configurations were assembled and various reactor physics experiments were conducted. These experiments included measurements of criticality, differential and integral control rod and safety rod worths, kinetics, reaction rates, water ingress effects, and small sample reactivity effects (Ref. 3). HTR-PROTEUS was constructed, and the experimental program was conducted, for the purpose of providing experimental benchmark data for assessment of reactor physics computer codes. Considerable effort was devoted to benchmark calculations as a part of the HTR-PROTEUS program. References 1 and 2 provide detailed data for use in constructing models for codes to be assessed. Reference 3 is a comprehensive summary of the HTR-PROTEUS experiments and the associated benchmark program. This document draws freely from these references. Only Cores 9 and 10 are evaluated in this benchmark report due to similarities in their construction. The other core configurations of the HTR-PROTEUS program are evaluated in their respective reports as outlined in Section 1.0. Cores 9 and 10 were evaluated and determined to be acceptable benchmark experiments.

Automatic X-ray inspection for the HTR-PM spherical fuel elements

Energy Technology Data Exchange (ETDEWEB)

Yi, DU, E-mail: duyi11@mails.tsinghua.edu.cn [Institute of Nuclear and New Energy Technology (INET), Tsinghua University, Energy Science Building A309, Haidian District, Beijing 100084 (China); Xiangang, WANG, E-mail: wangxiangang@tsinghua.edu.cn [Institute of Nuclear and New Energy Technology (INET), Tsinghua University, Energy Science Building A309, Haidian District, Beijing 100084 (China); Xincheng, XIANG, E-mail: inetxxc@tsinghua.edu.cn [Institute of Nuclear and New Energy Technology (INET), Tsinghua University, Energy Science Building, Haidian District, Beijing 100084 (China); Bing, LIU, E-mail: bingliu@tsinghua.edu.cn [Institute of Nuclear and New Energy Technology (INET), Tsinghua University, Energy Science Building, Haidian District, Beijing 100084 (China)

2014-12-15

Highlights: • An automatic X-ray inspection method is established to characterize HTR pebbles. • The method provides physical characterization and the inner structure of pebbles. • The method can be conducted non-destructively, quickly and automatically. • Sample pebbles were measured with this AXI method for validation. • The method shows the potential to be applied in situ. - Abstract: Inefficient quality assessment and control (QA and C) of spherical fuel elements for high temperature reactor-pebblebed modules (HTR-PM) has been a long-term problem, since conventional methods are labor intensive and cannot reveal the inside information nondestructively. Herein, we proposed a nondestructive, automated X-ray inspection (AXI) method to characterize spherical fuel elements including their inner structures based on X-ray digital radiography (DR). Briefly, DR images at different angles are first obtained and then the chosen important parameters such as spherical diameters, geometric and mass centers, can be automatically extracted and calculated via image processing techniques. Via evaluating sample spherical fuel elements, we proved that this AXI method can be conducted non-destructively, quickly and automatically. This method not only provides accurate physical characterization of spherical fuel elements but also reveals their inner structure with good resolution, showing great potentials to facilitate fast QA and C in HTM-PM spherical fuel element development and production.

Automatic X-ray inspection for the HTR-PM spherical fuel elements

International Nuclear Information System (INIS)

Yi, DU; Xiangang, WANG; Xincheng, XIANG; Bing, LIU

2014-01-01

Highlights: • An automatic X-ray inspection method is established to characterize HTR pebbles. • The method provides physical characterization and the inner structure of pebbles. • The method can be conducted non-destructively, quickly and automatically. • Sample pebbles were measured with this AXI method for validation. • The method shows the potential to be applied in situ. - Abstract: Inefficient quality assessment and control (QA and C) of spherical fuel elements for high temperature reactor-pebblebed modules (HTR-PM) has been a long-term problem, since conventional methods are labor intensive and cannot reveal the inside information nondestructively. Herein, we proposed a nondestructive, automated X-ray inspection (AXI) method to characterize spherical fuel elements including their inner structures based on X-ray digital radiography (DR). Briefly, DR images at different angles are first obtained and then the chosen important parameters such as spherical diameters, geometric and mass centers, can be automatically extracted and calculated via image processing techniques. Via evaluating sample spherical fuel elements, we proved that this AXI method can be conducted non-destructively, quickly and automatically. This method not only provides accurate physical characterization of spherical fuel elements but also reveals their inner structure with good resolution, showing great potentials to facilitate fast QA and C in HTM-PM spherical fuel element development and production

Advanced Characterization Techniques for Silicon Carbide and Pyrocarbon Coatings on Fuel Particles for High Temperature Reactors (HTR)

Energy Technology Data Exchange (ETDEWEB)

Basini, V.; Charollais, F. [CEA Cadarache, DEN/DEC/SPUA, BP 1, 13108 St Paul Lez Durance (France); Dugne, O. [CEA Marcoule, DEN/DTEC/SCGS BP 17171 30207 Bagnols sur Ceze (France); Garcia, C. [Laboratoire des Composites Thermostructuraux (LCTS), UMR CNRS 5801, 3 allee de La Boetie, 33600 Pessac (France); Perez, M. [CEA Grenoble DRT/DTH/LTH, 17 rue des Martyrs, 38054 Grenoble cedex 9 (France)

2008-07-01

Cea and AREVA NP have engaged an extensive research and development program on HTR (high temperature reactor) fuel. The improving of safety of (very) high temperature reactors (V/HTR) is based on the quality of the fuel particles. This requires a good knowledge of the properties of the four-layers TRISO particles designed to retain the uranium and fission products during irradiation or accident conditions. The aim of this work is to characterize exhaustively the structure and the thermomechanical properties of each unirradiated layer (silicon carbide and pyrocarbon coatings) by electron microscopy (SEM, TEM), selected area electronic diffraction (SEAD), thermo reflectance microscopy and nano-indentation. The long term objective of this study is to define pertinent parameters for fuel performance codes used to better understand the thermomechanical behaviour of the coated particles. (authors)

Comparative Study on Electric Generation Cost of HTR with Another Electric Plant Using LEGECOST Program

International Nuclear Information System (INIS)

Mochamad-Nasrullah; Soetrisnanto, Arnold Y.; Tosi-Prastiadi; Adiwardojo

2000-01-01

Monetary and economic crisis in Indonesia resulted in impact of electricity and demand and supply planning that it has to be reevaluated. One of the reasons is budget limitation of the government as well as private companies. Considering this reason, the economic calculation for all of aspect could be performed, especially the calculation of electric generation cost. This paper will discuss the economic aspect of several power plants using fossil and nuclear fuel including High Temperature Reactor (HTR). Using Levelized Generation Cost (LEGECOST) program developed by IAEA (International Atomic Energy Agency), the electric generation cost of each power plant could be calculated. And then, the sensitivity analysis has to be done using several economic parameters and scenarios, in order to be known the factors that influence the electric generation cost. It could be concluded, that the electric generation cost of HTR is cheapest comparing the other power plants including nuclear conventional. (author)

Modelling of fission product release behavior from HTR spherical fuel elements under accident conditions

International Nuclear Information System (INIS)

Verfondern, K.; Mueller, D.

1991-01-01

Computer codes for modelling the fission product release behavior of spherical fuel elements for High Temperature Reactors (HTR) have been developed for the purpose of being used in risk analyses for HTRs. An important part of the validation and verification procedure for these calculation models is the theoretical investigation of accident simulation experiments which have been conducted in the KueFA test facility in the Hot Cells at KFA. The paper gives a presentation of the basic modeling and the calculational results of fission product release from modern German HTR fuel elements in the temperature range 1600-1800 deg. C using the TRISO coated particle failure model PANAMA and the diffusion model FRESCO. Measurements of the transient release behavior for cesium and strontium and of their concentration profiles after heating have provided informations about diffusion data in the important retention barriers of the fuel: silicon carbide and matrix graphite. It could be shown that the diffusion coefficients of both cesium and strontium in silicon carbide can significantly be reduced using a factor in the range of 0.02 - 0.15 compared to older HTR fuel. Also in the development of fuel element graphite, a tendency towards lower diffusion coefficients for both nuclides can be derived. Special heating tests focussing on the fission gases and iodine release from the matrix contamination have been evaluated to derive corresponding effective diffusion data for iodine in fuel element graphite which are more realistic than the iodine transport data used so far. Finally, a prediction of krypton and cesium release from spherical fuel elements under heating conditions will be given for fuel elements which at present are irradiated in the FRJ2, Juelich, and which are intended to be heated at 1600/1800 deg. C in the KueFA furnace in near future. (author). 7 refs, 11 figs

Software Unit Testing during the Development of Digital Reactor Protection System of HTR-PM

International Nuclear Information System (INIS)

Guo Chao; Xiong Huasheng; Li Duo; Zhou Shuqiao; Li Jianghai

2014-01-01

Reactor Protection System (RPS) of High Temperature Gas-Cooled Reactor - Pebble bed Module (HTR-PM) is the first digital RPS designed and to be operated in the Nuclear Power Plant (NPP) of China, and its development process has receives a lot of concerns around the world. As a 1E-level safety system, the RPS has to be designed and developed following a series of nuclear laws and technical disciplines including software verification and validation (software V&V). Software V&V process demonstrates whether all stages during the software development are performed correctly, completely, accurately, and consistently, and the results of each stage are testable. Software testing is one of the most significant and time-consuming effort during software V&V. In this paper, we give a comprehensive introduction to the software unit testing during the development of RPS in HTR-PM. We first introduce the objective of the testing for our project in the aspects of static testing, black-box testing, and white-box testing. Then the testing techniques, including static testing and dynamic testing, are explained, and the testing strategy we employed is also introduced. We then introduce the principles of three kinds of coverage criteria we used including statement coverage, branch coverage, and the modified condition/decision coverage. As a 1E-level safety software, testing coverage needs to be up to 100% mandatorily. Then we talk the details of safety software testing during software development in HTR-PM, including the organization, methods and tools, testing stages, and testing report. The test result and experiences are shared and finally we draw a conclusion for the unit testing process. The introduction of this paper can contribute to improve the process of unit testing and software development for other digital instrumentation and control systems in NPPs. (author)

A Small Modular Reactor Design for Multiple Energy Applications: HTR50S

Energy Technology Data Exchange (ETDEWEB)

Yan, X.; Tachibana, Y.; Ohashi, H.; Sato, H.; Tazawa, Y.; Kunitomi, K. [Japan Atomic Energy Agency, Ibaraki (Japan)

2013-06-15

HTR50S is a small modular reactor system based on HTGR. It is designed for a triad of applications to be implemented in successive stages. In the first stage, a base plant for heat and power is constructed of the fuel proven in JAEA's 950 .deg. C, 30MWt test reactor HTTR and a conventional steam turbine to minimize development risk. While the outlet temperature is lowered to 750 .deg. C for the steam turbine, thermal power is raised to 50MWt by enabling 40% greater power density in 20% taller core than the HTTR. However the fuel temperature limit and reactor pressure vessel diameter are kept. In second stage, a new fuel that is currently under development at JAEA will allow the core outlet temperature to be raised to 900 .deg. C for the purpose of demonstrating more efficient gas turbine power generation and high temperature heat supply. The third stage adds a demonstration of nuclear-heated hydrogen production by a thermochemical process. A licensing approach to coupling high temperature industrial process to nuclear reactor will be developed. The low initial risk and the high longer-term potential for performance expansion attract development of the HTR50S as a multipurpose industrial or distributed energy source.

Polymorphisms in the 5-HTR2A gene related to obstructive sleep apnea syndrome Polimorfismos no gene HTR2A relacionados à síndrome da apneia obstrutiva do sono

Directory of Open Access Journals (Sweden)

Vânia Belintani Piatto

2011-06-01

Full Text Available Obstructive sleep apnea syndrome (OSAS is one of the most complex disorders of sleep; it involves several genetic factors that contribute to the phenotype. Serotonin (5-HT regulates a variety of visceral and physiological functions, including sleep. Gene 5-HTR2A polymorphisms may change the transcription of several receptors in the serotoninergic system, thereby contributing to OSAS. AIM: To investigate the prevalence of T102C and -1438G/A polymorphisms in the 5-HTR2A gene of patients with and without OSAS . MATERIAL AND METHOD: A molecular study of 100 index-cases and 100 controls of both genders. DNA was extracted from blood leukocytes samples and the regions that enclose both polymorphisms were amplified with PCR-RFLP. STUDY DESIGN: A cross-sectional case study. RESULTS: There was a significant prevalence of males in index cases compared to controls (pA síndrome da apneia obstrutiva do sono (SAOS é um dos distúrbios mais complexos do sono, envolvendo múltiplos fatores genéticos contribuintes para o fenótipo. A serotonina (5-HT está envolvida na regulação de uma variedade de funções viscerais e fisiológicas, inclusive o sono. Polimorfismos no gene 5-HTR2A podem alterar a transcrição, afetando o número de receptores do sistema serotoninérgico, contribuindo para a SAOS. OBJETIVO: Investigar a prevalência dos polimorfismos T102C e -1438G/A no gene HTR2A em pacientes com e sem SAOS. MATERIAL E MÉTODO: Estudo molecular em 100 pacientes como casos-índice e em 100 como grupo controle, de ambos os gêneros. O DNA foi extraído de leucócitos de sangue periférico e realizada a amplificação das regiões que abrangem ambos os polimorfismos pelas técnicas da PCR-RFLP. DESENHO DO ESTUDO: Estudo de caso/controle em corte transversal. Resultados: Houve prevalência significativa do gênero masculino nos casos-índice em relação aos controles (p<0,0001. Para o polimorfismo T102C, não houve diferença genotípica significante entre

Concept of safety related I and C and power supply systems in the passive safety concept of the HTR-module

International Nuclear Information System (INIS)

Juengst, U.

1990-01-01

The main motivation for the passive safety concepts is to gain a better quality of safety or at least to achieve higher public acceptance for nuclear power plants. This strategy has been introduced into the European Fast Reactor (EER), a common project of France, UK and Germany is applied stringently to the German high-temperature gas-cooled reactor ''HTR - Module''. The following fields are briefly described in the paper: Safety design features of the HTR - Module, overview of I and C concept, reactor protection system, emergency control room, power supply concept, system arrangement and protection against external hazards, accidents sequence of station black-out. (author). 3 figs

Analysis of hypothetical incidents in nuclear power plants with PWR and HTR

International Nuclear Information System (INIS)

Geiser, H.

1977-01-01

Several accident analyses are reviewed with a view to fission product release, and the findings are transferred to German reactor plants with LWR and HTR and compared. First of all, hypothetical accidents are compared for both of these lines; after this, the history of accidents is briefly described, and the fission product release during these accidents is investigated. For both reactor lines, there is a different but sufficiently high potential for safety improvements. (orig.) [de

Rapid blockade of telomerase activity and tumor cell growth by the DPL lipofection of ribbon antisense to hTR.

Science.gov (United States)

Bajpai, Arun K; Park, Jeong-Hoh; Moon, Ik-Jae; Kang, Hyungu; Lee, Yun-Han; Doh, Kyung-Oh; Suh, Seong-Il; Chang, Byeong-Churl; Park, Jong-Gu

2005-09-29

Ribbon antisense (RiAS) to the hTR RNA, a component of the telomerase complex, was employed to inhibit telomerase activity and cancer cell growth. The antisense molecule, hTR-RiAS, combined with enhanced cellular uptake was shown to effectively inhibit telomerase activity and cause rapid cell death in various cancer cell lines. When cancer cells were treated with hTR-RiAS, the level of hTR RNA was reduced by more than 90% accompanied with reduction in telomerase activity. When checked for cancer cell viability, cancer cell lines treated with hTR-RiAS using DNA+Peptide+Lipid complex showed 70-80% growth inhibition in 3 days. The reduced cell viability was due to apoptosis as the percentage of cells exhibiting the sub-G0 arrest and DNA fragmentation increased after antisense treatment. Further, when subcutaneous tumors of a colon cancer cell line (SW480) were treated intratumorally with hTR-RiAS, tumor growth was markedly suppressed with almost total ablation of hTR RNA in the tumor tissue. Cells in the tumor tissue were also found to undergo apoptosis after hTR-RiAS treatment. These results suggest that hTR-RiAS is an effective anticancer reagent, with a potential for broad efficacy to diverse malignant tumors.

Evidence for the effect of serotonin receptor 1A gene (HTR1A) polymorphism on tractability in Thoroughbred horses.

Science.gov (United States)

Hori, Y; Tozaki, T; Nambo, Y; Sato, F; Ishimaru, M; Inoue-Murayama, M; Fujita, K

2016-02-01

Tractability, or how easily animals can be trained and controlled, is an important behavioural trait for the management and training of domestic animals, but its genetic basis remains unclear. Polymorphisms in the serotonin receptor 1A gene (HTR1A) have been associated with individual variability in anxiety-related traits in several species. In this study, we examined the association between HTR1A polymorphisms and tractability in Thoroughbred horses. We assessed the tractability of 167 one-year-old horses reared at a training centre for racehorses using a questionnaire consisting of 17 items. A principal components analysis of answers contracted the data to five principal component (PC) scores. We genotyped two non-synonymous single nucleotide polymorphisms (SNPs) in the horse HTR1A coding region. We found that one of the two SNPs, c.709G>A, which causes an amino acid change at the intracellular region of the receptor, was significantly associated with scores of four of five PCs in fillies (all Ps Horses carrying an A allele at c.709G>A showed lower tractability. This result provides the first evidence that a polymorphism in a serotonin-related gene may affect tractability in horses with the effect partially different depending on sex. © 2015 Stichting International Foundation for Animal Genetics.

Proceedings of the workshop on structural design criteria for HTR

International Nuclear Information System (INIS)

Breitbach, G.; Schubert, F.; Nickel, H.

1989-04-01

The papers demonstrate the status of high temperature reactor technology with regard to its realization in the nuclear power industry of various countries (FRG, USA, Japan) as well as to the development of safety rules in Germany. The design criteria for HTR could be presented. The criteria already determine definitely and almost completely the relevant requirements of the component rules. The informations include the technical boundary conditions with regard to safety, the metallic high temperature components, a particular section dealing with the reactor pressure vessel, especially with the prestressed concrete vessel, and the structural graphite components. (DG)

Flood control construction of Shidao Bay nuclear power plant and safety analysis for hypothetical accident of HTR-PM

International Nuclear Information System (INIS)

Chen Yongrong; Zhang Keke; Zhu Li

2014-01-01

A series of events triggered by tsunami eventually led to the Fukushima nuclear accident. For drawing lessons from the nuclear accident and applying to Shidao Bay nuclear power plant flood control construction, we compare with the state laws and regulations, and prove the design of Shidao Bay nuclear power plant flood construction. Through introducing the history of domestic tsunamis and the national researches before and after the Fukushima nuclear accident, we expound the tsunami hazards of Shidao Bay nuclear power plant. In addition, in order to verify the safety of HTR-PM, we anticipate the contingent accidents after ''superposition event of earthquake and extreme flood'', and analyse the abilities and measures of HTR-PM to deal with these beyond design basis accidents (BDBA). (author)

HTR-Proteus Pebble Bed Experimental Program Cores 5,6,7,&8: Columnar Hexagonal Point-on-Point Packing with a 1:2 Moderator-to-Fuel Pebble Ratio

Energy Technology Data Exchange (ETDEWEB)

Bess, John D. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sterbentz, James W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Snoj, Luka [Idaho National Lab. (INL), Idaho Falls, ID (United States); Lengar, Igor [Idaho National Lab. (INL), Idaho Falls, ID (United States); Koberl, Oliver [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-03-01

PROTEUS is a zero-power research reactor based on a cylindrical graphite annulus with a central cylindrical cavity. The graphite annulus remains basically the same for all experimental programs, but the contents of the central cavity are changed according to the type of reactor being investigated. Through most of its service history, PROTEUS has represented light-water reactors, but from 1992 to 1996 PROTEUS was configured as a pebble-bed reactor (PBR) critical facility and designated as HTR-PROTEUS. The nomenclature was used to indicate that this series consisted of High Temperature Reactor experiments performed in the PROTEUS assembly. During this period, seventeen critical configurations were assembled and various reactor physics experiments were conducted. These experiments included measurements of criticality, differential and integral control rod and safety rod worths, kinetics, reaction rates, water ingress effects, and small sample reactivity effects (Ref. 3). HTR-PROTEUS was constructed, and the experimental program was conducted, for the purpose of providing experimental benchmark data for assessment of reactor physics computer codes. Considerable effort was devoted to benchmark calculations as a part of the HTR-PROTEUS program. References 1 and 2 provide detailed data for use in constructing models for codes to be assessed. Reference 3 is a comprehensive summary of the HTR-PROTEUS experiments and the associated benchmark program. This document draws freely from these references. Only Cores 9 and 10 are evaluated in this benchmark report due to similarities in their construction. The other core configurations of the HTR-PROTEUS program are evaluated in their respective reports as outlined in Section 1.0. Cores 9 and 10 were evaluated and determined to be acceptable benchmark experiments.

HTR-PROTEUS PEBBLE BED EXPERIMENTAL PROGRAM CORES 5, 6, 7, & 8: COLUMNAR HEXAGONAL POINT-ON-POINT PACKING WITH A 1:2 MODERATOR-TO-FUEL PEBBLE RATIO

Energy Technology Data Exchange (ETDEWEB)

John D. Bess

2013-03-01

PROTEUS is a zero-power research reactor based on a cylindrical graphite annulus with a central cylindrical cavity. The graphite annulus remains basically the same for all experimental programs, but the contents of the central cavity are changed according to the type of reactor being investigated. Through most of its service history, PROTEUS has represented light-water reactors, but from 1992 to 1996 PROTEUS was configured as a pebble-bed reactor (PBR) critical facility and designated as HTR-PROTEUS. The nomenclature was used to indicate that this series consisted of High Temperature Reactor experiments performed in the PROTEUS assembly. During this period, seventeen critical configurations were assembled and various reactor physics experiments were conducted. These experiments included measurements of criticality, differential and integral control rod and safety rod worths, kinetics, reaction rates, water ingress effects, and small sample reactivity effects (Ref. 3). HTR-PROTEUS was constructed, and the experimental program was conducted, for the purpose of providing experimental benchmark data for assessment of reactor physics computer codes. Considerable effort was devoted to benchmark calculations as a part of the HTR-PROTEUS program. References 1 and 2 provide detailed data for use in constructing models for codes to be assessed. Reference 3 is a comprehensive summary of the HTR-PROTEUS experiments and the associated benchmark program. This document draws freely from these references. Only Cores 9 and 10 are evaluated in this benchmark report due to similarities in their construction. The other core configurations of the HTR-PROTEUS program are evaluated in their respective reports as outlined in Section 1.0. Cores 9 and 10 were evaluated and determined to be acceptable benchmark experiments.

Distribution of tritium in a nuclear process heat plant with HTR

International Nuclear Information System (INIS)

Steinwarz, W.; Stoever, D.; Hecker, R.; Thiele, W.

1984-01-01

The application of HTR-process heat in chemical processes involves low contamination of the product by tritium permeation through the heat exchanger walls. According to conservative assumptions for the tritium release rate and based on experimental permeation data of the German R und D-program a tritium concentration in the PNP-product gas of about 10 pCi/g was calculated. The domestic use of the product gas in unvented kitchen ranges as the most important direct radiation exposure pathway then leads to an effective equivalent radiation dose of only 20 μrem/a. (orig.)

Needs in Research and Development on materials for the gas coolant nuclear system: HTR/VHTR and GFR; Besoins en R et D sur les materiaux pour les systemes nucleaires a caloporteur gaz: HTR/VHTR et GFR

Energy Technology Data Exchange (ETDEWEB)

Billot, Ph. [CEA Saclay, Dir. du Developpement et de l' Innovation Nucleares (DEN/DDIN), 91 - Gif Sur Yvette (France)

2003-07-01

This presentation takes stock on the materials for high temperature reactors HTR (850 C), very high temperature VHTR(>1000 C) and fast neutrons high temperature GGF(850 C). It concerns the welding materials for the vessel, Ni-based superalloys for gas turbines, coatings, graphite, ceramics and corrosion studies. (A.L.B.)

HTR-500 - a technical and engineered safeguards concept

International Nuclear Information System (INIS)

Schoening, J.; Wachholz, W.; Stoelzl, D.

1985-01-01

The plant succeeding the THTR-300 nuclear power plant, which has just started its trial phase of power operation, is the HTR-500. On behalf of the Arbeitsgemeinschaft Hochtemperaturreaktor (AHR), the BBC/HRB Group completed a preliminary project study of a nuclear power plant equipped with a high temperature reactor in the 500 MW power range, in which the changed requirements in the nuclear power market are taken into account and electricity generating costs are to be achieved which are competitive with those of a 1230 MW convoy pressurized water reactor of the present design. On this basis, construction documents are to be drafted, and the licensing procedure under the Atomic Energy Act is to be carried out, within a planning phase of roughly four years. (orig.) [de

'Once through' cycles in the pebble bed HTR

International Nuclear Information System (INIS)

Teuchert, E.

1977-12-01

In the pebble bed HTR the 'Once Through' cycles achieve a favorable conservation of uranium resources due to their high burnup and due to the relatively low fissile inventory. A detailed study is given for cycles with highly enriched uranium and thorium, 20% enriched uranium and thorium, and for the low (approximately 8%) enriched cycle. The recommended cycle is based on the known THTR fuel element in the Th/U (93%) cycle. The variant with separate Seed elements and Breed elements presents the best pioneer in view of later recycling and thermal breeding. The minimum proliferation risk is achieved in the Th/U (20%) cycle basing on the fuel element type of the AVR, due to the low amount and high denaturization of the disloaded plutonium. (orig.) [de

Application of grey model on analyzing the passive natural circulation residual heat removal system of HTR-10

Institute of Scientific and Technical Information of China (English)

ZHOU Tao; PENG Changhong; WANG Zenghui; WANG Ruosu

2008-01-01

Using the grey correlation analysis, it can be concluded that the reactor pressure vessel wall temperature has the strongest effect on the passive residual heat removal system in HTR (High Temperature gas-cooled Reactor),the chimney height takes the second place, and the influence of inlet air temperature of the chimney is the least. This conclusion is the same as that analyzed by the traditional method. According to the grey model theory, the GM(1,1) and GM(1, 3) model are built based on the inlet air temperature of chimney, pressure vessel temperature and the chimney height. Then the effect of three factors on the heat removal power is studied in this paper. The model plays an important role on data prediction, and is a new method for studying the heat removal power. The method can provide a new theoretical analysis to the passive residual heat removal system of HTR.

Analysis of Seismic Soil-Structure Interaction for a Nuclear Power Plant (HTR-10

Directory of Open Access Journals (Sweden)

Xiaoxin Wang

2017-01-01

Full Text Available The response of nuclear power plants (NPPs to seismic events is affected by soil-structure interactions (SSI. In the present paper, a finite element (FE model with transmitting boundaries is used to analyse the SSI effect on the response of NPP buildings subjected to vertically incident seismic excitation. Analysis parameters that affect the accuracy of the calculations, including the dimension of the domain and artificial boundary types, are investigated through a set of models. A numerical SSI analysis for the 10 MW High Temperature Gas Cooled Test Reactor (HTR-10 under seismic excitation was carried out using the developed model. The floor response spectra (FRS produced by the SSI analysis are compared with a fixed-base model to investigate the SSI effect on the dynamic response of the reactor building. The results show that the FRS at foundation level are reduced and those at higher floor levels are altered significantly when taking SSI into account. The peak frequencies of the FRS are reduced due to the SSI, whereas the acceleration at high floor levels is increased at a certain frequency range. The seismic response of the primary system components, however, is reduced by the analysed SSI for the HTR-10 on the current soil site.

Auxiliary bearing design and rotor dynamics analysis of blower fan for HTR-10

International Nuclear Information System (INIS)

Gao Mingshan; Yang Guojun; Xu Yang; Zhao Lei; Yu Suyuan

2005-01-01

The electromagnetic bearing instead of ordinary mechanical bearing was chosen to support the rotor in the blower fan system with helium of 10 MW high temperature gas-cooled test reactor (HTR-10), and the auxiliary bearing was applied in the HTR-10 as the backup protector. When the electromagnetic bearing doesn't work suddenly for the power broken, the auxiliary bearing is used to support the falling rotor with high rotating speed. The rotor system will be protected by the auxiliary bearing. The design of auxiliary bearing is the ultimate safeguard for the system. This rotor is vertically mounted to hold the blower fan. The rotor's length is about 1.5 m, its weight is about 240 kg and the rotating speed is about 5400 r/min. Auxiliary bearing design and rotor dynamics analysis are very important for the design of blower fan to make success. The research status of the auxiliary bearing was summarized in the paper. A sort of auxiliary bearing scheme was proposed. MSC.Marc was selected to analyze the vibration mode and the natural frequency of the rotor. The scheme design of auxiliary bearing and analysis result of rotor dynamics offer the important theoretical base for the protector design and control system of electromagnetic bearing of the blower fan. (authors)

A network-based system of simulation, control and online assistance for HTR-10

Energy Technology Data Exchange (ETDEWEB)

Zhu Shutang [Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084 (China)], E-mail: zhust@tsinghua.edu.cn; Luo Shaojie; Shi Lei [Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084 (China)

2008-07-15

A network-based computer system has been developed for HTR-10. This system integrates three subsystems: the simulation subsystem (SIMUSUB), the visualized control designed subsystem (VCDSUB) and the online assistance subsystem (OASUB). The SIMUSUB consists of four functional elements: the simulation calculating server (SCS), the main control client (MCC), the data disposal client (DDC) and the results graphic display client (RGDC), all of which can communicate with each other via network. It is intended to analyze and calculate physical processes of the reactor core, the main loop system and the steam generator, etc., as well as to simulate the normal operational and transient accidents. The result data can be dynamically displayed through the RGDC. The VCDSUB provides a platform for control system modeling where the control flow systems can be automatically generated and graphically simulated. Based on the data from the field bus, the OASUB provides some of the reactor core parameters, which are difficult to measure. This integrated system can be used as an educational tool to understand the design and operational characteristics of the HTR-10, and can also provide online support for operators in the main control room, or as a convenient powerful tool for the control system design.

A network-based system of simulation, control and online assistance for HTR-10

International Nuclear Information System (INIS)

Zhu Shutang; Luo Shaojie; Shi Lei

2008-01-01

A network-based computer system has been developed for HTR-10. This system integrates three subsystems: the simulation subsystem (SIMUSUB), the visualized control designed subsystem (VCDSUB) and the online assistance subsystem (OASUB). The SIMUSUB consists of four functional elements: the simulation calculating server (SCS), the main control client (MCC), the data disposal client (DDC) and the results graphic display client (RGDC), all of which can communicate with each other via network. It is intended to analyze and calculate physical processes of the reactor core, the main loop system and the steam generator, etc., as well as to simulate the normal operational and transient accidents. The result data can be dynamically displayed through the RGDC. The VCDSUB provides a platform for control system modeling where the control flow systems can be automatically generated and graphically simulated. Based on the data from the field bus, the OASUB provides some of the reactor core parameters, which are difficult to measure. This integrated system can be used as an educational tool to understand the design and operational characteristics of the HTR-10, and can also provide online support for operators in the main control room, or as a convenient powerful tool for the control system design

Study of the Effect of Burnable Poison Particles Applying in a Pebble Bed HTR

International Nuclear Information System (INIS)

Wei Chunlin; Zhao Jing; Zhang Jian; Xia Bing

2014-01-01

In pebble bed high temperature gas cooled reactors (HTR), spherical fuel elements pass through the core several times to balance the burnup process in the fuel region, resulting in an acceptable shape and peak factor of power density in the simulation analysis. In contrast, when fuel elements pass through the core only once, the peak of power density occurs at the top of the core and its value is too high to be safe. These indicators/parameters can be improved by incorporating burnable poison in the fuel elements under certain conditions. In the current study, burnable poison particles (BPPs) in fuel elements are evaluated. In spite of the strong absorption capability of "1"0B, BPPs can decrease the depletion speed and increase the duration of "1"0B because of the self-shielding effect, resulting in improved shape and peak factor of power distribution. Several BPPs with different radius are discussed in power distribution, following the calculation for a full-scale reactor core with modified VSOP code. According the result, applying BPPs on fuel pebbles is an effective means to improve the distribution of the power density under one-through fuel load in HTR. (author)

The Preliminary GAMMA Code Thermal hydraulic Analysis for the Steady State of HTR-10 Initial Core

Energy Technology Data Exchange (ETDEWEB)

Jun, Ji Su; Lim, Hong Sik; Lee, Won Jae

2006-07-15

This report describes the preliminary thermalhydraulic analysis of HTR-10 steady state full power initial core to provide a benchmark calculation of VHTGR(Very High-Temperature Gas-Cooled Reactors) safety analysis code of GAMMA(GAs Multicomponent Mixture Analysis). The input data of GAMMA code are produced for the models of fluid block, wall block, radiation heat transfer and each component material properties in HTR-10 reactor. The temperature and flow distributions of HTR-10 steady state 10 MW{sub th} full power initial core are calculated by GAMMA code with boundary conditions of total reactor inlet flow rate of 4.32 kg/s, inlet temperature of 250 .deg. C, inlet pressure of 3 MPa, outlet pressure of 2.992 MPa and the fixed temperature at RCCS water cooling tube of 50 .deg C. The calculation results are compared with the measured solid material temperatures at 22 fixed instrumentation positions in HTR-10. The wall temperature distribution in pebble bed core shows that the minimum temperature of 358 .deg. C is located at upper core, a higher temperature zone than 829 .deg. C is located at the inner region of 0.45 m radius at the bottom of core centre, and the maximum wall temperature is 897 .deg. C. The wall temperatures linearly decreases at radially and axially farther side from the bottom of core centre. The maximum temperature of RPV is 230 .deg. C, and the maximum values of fuel average temperature and TRISO centreline temperature are 907 .deg. C and 929 .deg. C, respectively and they are much lower than the fuel temperature limitation of 1230 .deg. C. The comparsion between the GAMMA code predictions and the measured temperature data shows that the calculation results are very close to the measured values in top and side reflector region, but a great difference is appeared in bottom reflector region. Some measured data are abnormally high in bottom reflector region, and so the confirmation of data is necessary in future. Fifteen of twenty two data have a

Research on application of burnable poison in pebble bed HTR

International Nuclear Information System (INIS)

Wei Chunlin; Zhang Jian; Shan Wenzhi; Jing Xingqing

2013-01-01

Burnable poison in fuel ball was used in pebble bed high-temperature gas-cooled reactor (HTR) to optimize the shape and the peak factor of power distribution in certain conditions. Two options are available and evaluated, that is the homogeneous burnable poison in graphite matrix and burnable poison particles (BPPs) in fuel balls. Due to the absorption cross section of "1"0B, the depletion speed for homogeneous burnable poison is very fast, and difficult to control, on the other side, the depletion speed of BPPs can be optimized respecting to its size, and better shape and peak value of power distribution can be achieved. (authors)

Reactive Oxygen Stimulation of Interleukin-6 Release in the Human Trophoblast Cell Line HTR-8/SVneo by the Trichlorethylene Metabolite S-(1,2-Dichloro)-l-Cysteine.

Science.gov (United States)

Hassan, Iman; Kumar, Anjana M; Park, Hae-Ryung; Lash, Lawrence H; Loch-Caruso, Rita

2016-09-01

Trichloroethylene (TCE) is a common environmental pollutant associated with adverse reproductive outcomes in humans. TCE intoxication occurs primarily through its biotransformation to bioactive metabolites, including S-(1,2-dichlorovinyl)-l-cysteine (DCVC). TCE induces oxidative stress and inflammation in the liver and kidney. Although the placenta is capable of xenobiotic metabolism and oxidative stress and inflammation in placenta have been associated with adverse pregnancy outcomes, TCE toxicity in the placenta remains poorly understood. We determined the effects of DCVC by using the human extravillous trophoblast cell line HTR-8/SVneo. Exposure to 10 and 20 μM DCVC for 10 h increased reactive oxygen species (ROS) as measured by carboxydichlorofluorescein fluorescence. Moreover, 10 and 20 μM DCVC increased mRNA expression and release of interleukin-6 (IL-6) after 24-h exposure, and these responses were inhibited by the cysteine conjugate beta-lyase inhibitor aminooxyacetic acid and by treatments with antioxidants (alpha-tocopherol and deferoxamine), suggesting that DCVC-stimulated IL-6 release in HTR-8/SVneo cells is dependent on beta-lyase metabolic activation and increased generation of ROS. HTR-8/SVneo cells exhibited decreased mitochondrial membrane potential at 5, 10, and 20 μM DCVC at 5, 10, and 24 h, showing that DCVC induces mitochondrial dysfunction in HTR-8/Svneo cells. The present study demonstrates that DCVC stimulated ROS generation in the human placental cell line HTR-8/SVneo and provides new evidence of mechanistic linkage between DCVC-stimulated ROS and increase in proinflammatory cytokine IL-6. Because abnormal activation of cytokines can disrupt trophoblast functions necessary for placental development and successful pregnancy, follow-up investigations relating these findings to physiologic outcomes are warranted. © 2016 by the Society for the Study of Reproduction, Inc.

Simulation of thermal-hydraulic process in reactor of HTR-PM based on flow and heat transfer network

International Nuclear Information System (INIS)

Zhou Kefeng; Zhou Yangping; Sui Zhe; Ma Yuanle

2012-01-01

The development of HTR-PM full scale simulator (FSS) is an important part in the project. The simulation of thermal-hydraulic process in reactor is one of the key technologies in the development of FSS. The simulation of thermal-hydraulic process in reactor was studied. According to the geometry structures and the characteristics of thermal-hydraulic process in reactor, the model was setup in components construction way. Based on the established simulation method of flow and heat transfer network, a Fortran code was developed and the simulation of thermal-hydraulic process was achieved. The simulation results of 50% FP steady state, 100% FP steady state and control rod mistakenly ascension accidents were given. The verification of simulation results was carried out by comparing with the design and analysis code THERMIX. The results show that the method and model based on flow and heat transfer network can meet the requirements of FSS and reflect the features of thermal-hydraulic process in HTR-PM. (authors)

Computational fluid dynamic model for thermohydraulic calculation for the steady-state of the real scale HTR-1

Energy Technology Data Exchange (ETDEWEB)

Gamez, Abel; Rojas, Leorlen; Rosales, Jesus; Castro, Landy Y.; Gonzalez, Daniel; Garcia, Carlos, E-mail: agamezgmf@gmail.com, E-mail: leored1984@gmail.com, E-mail: jrosales@instec.cu, E-mail: lcastro@instec.cu, E-mail: danielgonro@gmail.com, E-mail: cgr@instec.cu [Instituto Superior de Tecnologias y Ciencias Aplicadas (InSTEC), La Habana (Cuba); Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil); Oliveira, Carlos B. de, E-mail: cabol@ufpe.br [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil); Dominguez, Dany S., E-mail: dsdominguez@gmail.com [Universidade Estadual de Santa Cruz (UESC), Ilheus, BA (Brazil)

2015-07-01

The high temperature gas cooled reactor (HTGR) is one of candidates of next generation of nuclear reactor according to IAEA report 2013. Evaluation of thermohydraulic performance and an experimental comparison results were proposed to the international research community. In this article, the tree dimensional CFD thermohydraulic modelation of steady state of HTR-10 modular reactor, using ANSYS CFX v14.0, has been done. Code-to-code and Code-to-experiment benchmark analyses, related to the testing program of the HTR-10 plant including steady state temperature distribution with the reactor at full power, were developed. The 3D real scale representation of reflector zone and fluid path flow inner and outer reflector blocks and cold helium cavity were carried out. The porous medium model was used to simulate the core zone in the reactor. The power distribution of the initial core published by IAEA-TECDOC-1694 obtained by Chief Scientific Investigators (CSIs) from China was used as heat sources in the core zone. (author)

Key technology for (V)HTR: laser beam joining of SiC

International Nuclear Information System (INIS)

Knorr, J.; Lippmann, W.; Reinecke, A.M.; Wolf, R.; Rasper, R.; Kerber, A.; Wolter, A.

2005-01-01

Laser beam joining has numerous advantages over other methods presently known. After having been developed successful for brazing silicon carbide for high temperature applications, this technology is now also available for silicon nitride. Thus the field of application of SiC and Si 3 N 4 which are very interesting materials for the nuclear sector is considerably extended thanks to this new technology. Ceramic encapsulation of fuel and absorber increases the margins for operation at very high temperatures. Additionally, without ceramic encapsulation of the main core components, it will be difficult to continue claiming non-catastrophic behaviour for the (V)HTR. (orig.)

KüFA safety testing of HTR fuel pebbles irradiated in the High Flux Reactor in Petten

Energy Technology Data Exchange (ETDEWEB)

Seeger, O., E-mail: oliver.seeger@rwth-aachen.de [European Commission, Joint Research Centre (JRC), Institute for Transuranium Elements (ITU), Safety of Irradiated Nuclear Materials Unit, Postfach 2340, 76125 Karlsruhe (Germany); Laurie, M., E-mail: mathias.laurie@ec.europa.eu [European Commission, Joint Research Centre (JRC), Institute for Transuranium Elements (ITU), Safety of Irradiated Nuclear Materials Unit, Postfach 2340, 76125 Karlsruhe (Germany); Abjani, A. El; Ejton, J.; Boudaud, D.; Freis, D.; Carbol, P.; Rondinella, V.V. [European Commission, Joint Research Centre (JRC), Institute for Transuranium Elements (ITU), Safety of Irradiated Nuclear Materials Unit, Postfach 2340, 76125 Karlsruhe (Germany); Fütterer, M. [European Commission, Joint Research Centre (JRC), Institute for Energy and Transport (IET), Nuclear Reactor Integrity Assessment and Knowledge Management Unit, PO Box 2, 1755 ZG Petten (Netherlands); Allelein, H.-J. [Lehrstuhl für Reaktorsicherheit und -technik an der RWTH Aachen, Kackertstraße 9, 52072 Aachen (Germany)

2016-09-15

The Cold Finger Apparatus (KühlFinger-Apparatur—KüFA) in operation at JRC-ITU is designed to experimentally scrutinize the effects of Depressurization LOss of Forced Circulation (D-LOFC) accident scenarios on irradiated High Temperature Reactor (HTR) fuel pebbles. Up to 1600 °C, the reference maximum temperature for these accidents, high-quality German HTR fuel pebbles have already demonstrated a small fission product release. This paper discusses and compares the releases obtained from KüFA-testing the pebbles HFR-K5/3 and HFR-EU1/3, which were both irradiated in the High Flux Reactor (HFR) in Petten. We present the time-dependent fractional release of the volatile fission product {sup 137}Cs as well as the fission gas {sup 85}Kr for both pebbles. For HFR-EU1/3 the isotopes {sup 134}Cs and {sup 154}Eu as well as the shorter-lived {sup 110m}Ag have also been measured. A detailed description of the experimental setup and its accuracy is given. The data for the recently tested pebbles is discussed in the context of previous results.

Experimental and numerical investigation of the flow measurement method utilized in the steam generator of HTR-PM

Energy Technology Data Exchange (ETDEWEB)

Wang, Shiming; Ren, Cheng; Sun, Yangfei [Institute of Nuclear and New Energy Technology of Tsinghua University, Collaborative Innovation Center of Advanced Nuclear Energy Technology, Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education, Beijing 100084 (China); Tu, Jiyuan [Institute of Nuclear and New Energy Technology of Tsinghua University, Collaborative Innovation Center of Advanced Nuclear Energy Technology, Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education, Beijing 100084 (China); School of Aerospace, Mechanical & Manufacturing Engineering, RMIT University, Melbourne, VIC 3083 (Australia); Yang, Xingtuan, E-mail: yangxt107@sina.com [Institute of Nuclear and New Energy Technology of Tsinghua University, Collaborative Innovation Center of Advanced Nuclear Energy Technology, Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education, Beijing 100084 (China)

2016-08-15

Highlights: • The flow confluence process in the steam generator is very important for HTR-PM. • The complicated flow in the unique pipeline configuration is studied by both of experimental and numerical method. • The pressure uniformity at the bottom of the model was tested to evaluate the accuracy of the experimental results. • Flow separation and the secondary flow is described for explaining the nonuniformity of the flow distribution. - Abstract: The helium flow measurement method is very important for the design of HTR-PM. Water experiments and numerical simulation with a 1/5 scaled model are conducted to investigate the flow measurement method utilized in the steam generator of HTR-PM. Pressure information at specific location of the 90° elbows with the diameter of 46.75 mm and radius ratio of 1.5 is measured to evaluate the flow rate in the riser-pipes. Pressure uniformity at the bottom of the experimental apparatus is tested to evaluate the influence of the equipment error on the final experimental results. Numerical results obtained by using the realizable k–ε model are compared with the experimental data. The results reveal that flow oscillation does not occur in the confluence system. For every single riser-pipe, the flow is stable despite the nonuniformity of the flow distribution. The average flow rates of the two pipe series show good repeatability regardless of the increases and decreases of the average velocity. In the header box, the flows out of the riser-pipes encounter with each other and finally distort the pressure distribution and the nonuniformity of the flow distribution becomes more significant along with the increasing Reynolds number.

The role of the Cys23Ser (rs6318) polymorphism of the HTR2C gene in suicidal behavior: systematic review and meta-analysis.

Science.gov (United States)

González-Castro, Thelma B; Hernandez-Diaz, Yazmín; Juárez-Rojop, Isela E; López-Narváez, Lilia; Tovilla-Zárate, Carlos A; Rodriguez-Perez, José M; Sánchez-de la Cruz, Juan P

2017-12-01

The polymorphisms of the serotonin receptor 2C (HTR2C) gene have been proposed to influence suicidal behavior. The aim of our study was to explore the role of the HTR2C gene variant Cys23Ser (rs6318) in the pathogenesis of suicidal behavior through a systematic review and meta-analysis. The search was performed using EBSCO and PubMed databases. To be included in the analysis, the studies had to evaluate suicidal behavior (attempted, ideation, or completed suicide). The results of the meta-analysis were expressed as odds ratios (ORs). Because HTR2C lies on chromosome X, pooled ORs were calculated, respectively, for each of the models used, namely: allelic, homozygous, dominant, and recessive for the female group and allelic for the male group. The meta-analysis comprised 3867 individuals, including 1668 cases and 2199 controls. The HTR2C Cys23Ser (rs6318) polymorphism did not show a significant association with suicidal behavior either in women (OR: 0.75; 95% confidence interval: 0.55-1.00) or in men (OR: 0.89; 95% confidence interval: 0.64-1.23). Similarly, nonsignificant associations were observed for all of the genetic models used in any of the populations/subgroups studied. Our findings suggest that the rs6318 (Cys23Ser) polymorphism is not associated with suicidal behavior. However, because of the study limitations, we suggest more researches should be performed, increasing the sample sizes and statistical power, to determine the association between the rs6318 variant and suicidal behavior.

Factors influencing selection of a HTR for a developing country

International Nuclear Information System (INIS)

Karim, C.S.

1989-01-01

Consumption of commercial energy and electricity in Bangladesh has to grow rapidly in order to attain socio-economic development of the country. Nuclear power is considered to be an appropriate proposition due to the inadequacy of indigenous primary energy resources. A technical, economic and financial feasibility study of a 300-500 MWe nuclear power plant is underway now. Responses from different suppliers in SMPR range were enumerated jointly by the Consultants and BAEC under the feasibility study. Criteria for selection of technology and the factor influencing the selection of Modular HTR for Bangladesh are described in the paper. Some indicative results of cost economic calculations are included to help form an idea about various limiting conditions, under which a SMPR with the selected technology could become competitive with the other conventional alternatives. Problems in decision making associated with the uncertainties in estimating plant and fuel cycle costs are enumerated. The implications of not having a reference plant vis-a-vis the advantageous safety features are described to show how these aspects can influence the selection of a new technology like HTR for a developing country. Financing is identifiable as the major problem in implementing a nuclear power project in a developing country like Bangladesh. The entire scope of supplies and services may be broken down into components, so that the burden of financing could be shared by more than one exporting country. Some indicative ideas about the packaging of supplies and services are presented in the paper in order to identify different types of financing sources that could be explored for implementation of the project. Some salient features of the effect of joint-venture on the project financing and implementation are described in the paper. (author). 3 refs, 1 fig

DEM simulation of particle mixing for optimizing the overcoating drum in HTR fuel fabrication

Science.gov (United States)

Liu, Malin; Lu, Zhengming; Liu, Bing; Shao, Youlin

2013-06-01

The rotating drum was used for overcoating coated fuel particles in HTR fuel fabrication process. All the coated particles should be adhered to equal amount of graphite powder, which means that the particle should be mixed quickly in both radial and axial directions. This paper investigated the particle flow dynamics and mixing behavior in different regimes using the discrete element method (DEM). By varying the rotation speed, different flow regimes such as slumping, rolling, cascading, cataracting, centrifuging were produced. The mixing entropy based on radial and axial grid was introduced to describe the radial and axial mixing behaviors. From simulation results, it was found that the radial mixing can be achieved in the cascading regime more quickly than the slumping, rolling and centrifuging regimes, but the traditional rotating drum without internal components can not achieve the requirements of axial mixing and should be improved. Three different structures of internal components are proposed and simulated. The new V-shaped deflectors were found to achieve a quick axial mixing behavior and uniform axial distribution in the rotating drum based on simulation results. At last, the superiority was validated by experimental results, and the new V-shaped deflectors were used in the industrial production of the overcoating coated fuel particles in HTR fuel fabrication process.

Irradiation behaviour of advanced fuel elements for the helium-cooled high temperature reactor (HTR)

International Nuclear Information System (INIS)

Nickel, H.

1990-05-01

The design of modern HTRs is based on high quality fuel. A research and development programme has demonstrated the satisfactory performance in fuel manufacturing, irradiation testing and accident condition testing of irradiated fuel elements. This report describes the fuel particles with their low-enriched UO 2 kernels and TRISO coating, i.e. a sequence of pyrocarbon, silicon carbide, and pyrocarbon coating layers, as well as the spherical fuel element. Testing was performed in a generic programme satisfying the requirements of both the HTR-MODUL and the HTR 500. With a coating failure fraction less than 2x10 -5 at the 95% confidence level, the results of the irradiation experiments surpassed the design targets. Maximum accident temperatures in small, modular HTRs remain below 1600deg C, even in the case of unrestricted core heatup after depressurization. Here, it was demonstrated that modern TRISO fuels retain all safety-relevant fission products and that the fuel does not suffer irreversible changes. Isothermal heating tests have been extended to 1800deg C to show performance margins. Ramp tests to 2500deg C demonstrate the limits of present fuel materials. A long-term programm is planned to improve the statistical significance of presently available results and to narrow remaining uncertainty limits. (orig.) [de

Needs in Research and Development on materials for the gas coolant nuclear system: HTR/VHTR and GFR

International Nuclear Information System (INIS)

Billot, Ph.

2003-01-01

This presentation takes stock on the materials for high temperature reactors HTR (850 C), very high temperature VHTR(>1000 C) and fast neutrons high temperature GGF(850 C). It concerns the welding materials for the vessel, Ni-based superalloys for gas turbines, coatings, graphite, ceramics and corrosion studies. (A.L.B.)

Concept licensing procedure for an HTR-module nuclear power plant

International Nuclear Information System (INIS)

Brinkmann, G.; Will, M.

1990-01-01

In April 1987 the companies Siemens and Interatom applied in the West German state of Lower Saxony for a concept licensing procedure to be initiated for an HTR-Module nuclear power plant. In addition to a safety analysis report, numerous additional papers were submitted to the authorized experts. In April 1989 proceedings were suspended for political and legal reasons. By this time both the fire protection report and the plant security concept report had been completed. The safety concept review was continued by order of the Federal Minister for Research and Technology. The draft safety concept report was completed in July 1989. The final version was completed at the end of 1989. (orig.)

A 3-D inelastic analysis of HTR graphite structures and a comparison with A 2-D approach

International Nuclear Information System (INIS)

Willaschek, J.

1979-01-01

In High Temperature Reactor Cores (HTR) a large number of elements are constructed of nuclear graphite. The dimensions of the graphite components are limited by stresses and strains resulting from thermal loads, irradiation induced dimensional changes and stress-dependent irradiation creep. Therefore it is necessary to examine the feasibility of design concepts with regard to the structural integrity of the material. This paper presents an analysis of a radial reflector concept for use in a 3000 MWth HTR for process heat production. This concept of a pebble bed reactor (OTTO cycle) requires reflector dimensions and shapes which have previously not been used and which may exceed acceptable stress limits. Graphite reflector elements in a HTR are subject to a high fluence of fast neutrons. The fluence varies spatially within an element. Irradiation-induced strains occur which in turn vary non-linearly with the fluence. At low fluences the graphite shrinks. With increasing fluence shrinkage is saturated and after a 'turn-around' point the graphite begins to swell. The net effect of fluence gradient and irradiation-induced strain is a 'necking' of the element which moves radially outwards with time. In this paper a three-dimensional inelastic analysis of a graphite block with the above deformation history is described. The influence of irradiation on dimensional stability and other material properties was taken into account. Numerical results were obtained with the finite-element computer code ADINA, modified at INTERATOM for the task in hand. The radial reflector block was modelled using 21-node three-dimensional continuum elements of elastic-creep material. The element stiffness matrices were calculated using the standard 2x2x2 Gauss integration; material nonlinearities with quadratic displacement functions and linearised initial strains were employed. (orig.)

Microscopic thermal characterization of HTR particle layers

International Nuclear Information System (INIS)

Rochais, D.; Le Meur, G.; Basini, V.; Domingues, G.

2008-01-01

This paper presents thermal diffusivity measurements of HTR fuel particle pyrolytic carbon layers at room temperature. The photoreflectance microscopy (PM) technique is used to characterize particle layers at a microscopic scale. Nevertheless, buffer layer needs a particular analysis due to its porous structure. Indeed, measurements by PM on this material only permit to obtain the thermal diffusivity of the solid skeleton, whose homogeneous zones surface does not exceed 100 μm 2 . These characteristics make, on the one hand, delicate the use of PM, and on the other hand, require the use of a numerical homogenization technique. This model takes into account the properties of gas confined in the pores, to simulate the conduction heat flux traveling through the layer in relation with its microstructure and to estimate an effective thermal conductivity of the entire layer. This approach is validated by infrared microscopy measurement of the effective thermal diffusivity of the especially elaborated thicker buffer layer. Last, the first tests to characterize the silicon carbide layer are presented

C.A.S.H. - a transient integrated plant model for a HTR-module power plant. User manual

International Nuclear Information System (INIS)

Biesenbach, R.; Lauer, A.; Struth, S.

1997-07-01

The computer code C.A.S.H. has been developed as an integrated plant model for the HTR-Module reactor, in order to treat safety related questions about this type of power plant which require a detailed numeric simulation of the transient behaviour of the integrated plant. The present report contains the user manual for this plant model. It consists of three parts: In the first part, the code structure and functions, the course of the simulation calculations, and important code parts are described. The second part is devoted to the practical application and explains extensively the handling of the complex code system with several sample calculations. These computing cases comprise load-follow transients and the shutdown procedure of the HTR-Module and are presented and discussed with the full input data, job patterns, and numerous computer graphics. The third part contains the input manual of C.A.S.H. and is rather extensive as it includes the complete inputs of several reactor component computer codes along with the control program of the integrated plant model. (orig./DG) [de

The Hitrex Programme: unperturbed HTR lattice and control rod measurements

Energy Technology Data Exchange (ETDEWEB)

Beynon, A J; Nunn, D L

1972-06-15

Reactivity, power distributions, plutonium production and fast neutron graphite damage are being studied at Berkeley Nuclear Laboratories (BNL) on the HTR 'Hitrex' reactor under cold clean conditions. Rod interactions, important in assessing local criticality hazards, are receiving special attention in the measurements. The proposals for the first two series of measurements on Hitrex are discussed in this note, Hitrex 1a being the unperturbed reactor, and Hitrex 1b the same fuel array but with a number of different control absorber loadings in it. Common to both series will be cross pin, cross block and cross core measurements of power rating, thermal spectrum and damage dose distributions, so that these will be known as functions of the fuel, reflector and absorber environment.

Rework of process effluents from the fabrication of HTR fuel

International Nuclear Information System (INIS)

Lasberg, Ingo; Braehler, Georg; Boyes, David

2008-01-01

HTR fuel facilities require the application of several liquid chemicals and accordingly they produce significant amounts of Uranium contaminated/potentially contaminated effluents. The main effluents are (amounts for a 3 t Uranium/a plant): aqueous solutions including tetrahydrofurfuryl alcohol THFA, ammonium hydroxide NH4OH, and ammonium nitrate NH4NO3 (180 m 3 /a), isopropanol IPA/water mixtures (130 m 3 /a); Non-Process Water NPW (300 m 3 /a); methanol (7m 3 /a); additionally off-gas streams, containing ammonia (9 t/a) have to be treated. In an industrial scale facility all such effluents/gases need to be processed for recycling, decontamination prior to release to the environment (as waste or as valuable material). Thermal decomposition is applied to dispose of burnable residues.

Fission product behaviour - in particular Cs-137 - in HTR-TRISO-coated particle fuel

International Nuclear Information System (INIS)

Allelein, H.J.

1980-12-01

This work is performed between 1977 and 1979. The main task is to determine a temperature dependent diffusion coefficient of the fission product Cs-137 in the silicon carbide interlayer of HTR particles. The raw material is laso presented as the used measuring techniques and computer codes. The results are discussed in detail and some critical remarks are made about the efficiency of the silicon carbide interlayer to retent fission products including Ag-110m, Sr-90, and Ru-106, which temperature dependent diffusion coefficient is also been determined. (orig.) [de

HTR 500: Final report of the project '' uniaxial creep tests at controlled temperature''

International Nuclear Information System (INIS)

1992-03-01

The report presents the results of creep trials with HTR-concrete, which were carried out in the scope of development of prestressed concrete - reactor pressure vessels at the ETH Lausanne Institute for Steel and Prestressed Concrete. With temperature, an increase of creep and shrinkage was observed, a lesser dependence on exhaustion and type of concrete. The point in time of reaching the final value is not dependent on temperature for creep, but is for shrinkage. The modulus of elasticity depends on the temperature pre-treatment, but only insignificantly on the test temperature. figs., tabs

Relationship between the rs1414334 C/G polymorphism in the HTR2C gene and smoking in patients treated with atypical antipsychotics.

Science.gov (United States)

Rico-Gomis, José María; Palazón-Bru, Antonio; Triano-García, Irene; Mahecha-García, Luis Fabián; García-Monsalve, Ana; Navarro-Ruiz, Andrés; Villagordo-Peñalver, Berta; Martínez-Hortelano, Alicia; Gil-Guillén, Vicente Francisco

2018-04-15

An association has been found between the C allele of the rs1414334 polymorphism in the HTR2C gene and the metabolic syndrome in psychiatric patients. However, no study has yet evaluated whether this allele is associated with smoking. To assess this issue, therefore, we performed a cross-sectional study with a sample of 166 adult patients treated with atypical antipsychotics in 2012-2013 in a region of Spain. The primary variable was the presence of the C allele of the rs1414334 polymorphism in the HTR2C gene. Secondary variables were the number of pack-years (number of cigarettes per day x number of smoking years ÷ 20), age, gender, schizophrenia, years since diagnosis, metabolic syndrome criteria and SCORE. A stepwise binary logistic regression model was constructed to determine associations between primary and secondary variables and their area under the ROC curve (AUC) was calculated. Of the total sample, 33 patients (19.9%) had the C allele of the polymorphism analyzed. Mean cigarette consumption was 11.6 pack-years. The multivariate analysis showed the following factors as associated with the polymorphism: higher cigarette consumption, being a woman, and not having abdominal obesity. The AUC was 0.706. An association was found between increased cigarette consumption over the years and the presence of the C allele of the rs1414334 polymorphism in the HTR2C gene.

Technology assessment HTR. Part 3. Economics of new concept of the modular High Temperature Reactor

International Nuclear Information System (INIS)

Lako, P.

1996-06-01

In this study the economic feasibility of new concepts of the High Temperature Reactor were investigated. These new concepts are characterized as inherently safe. The different concepts were used as industrial heat/power reactors and compared with a gas fired Steam and Gas turbine installation. The best economic advantages are offered by a HTR with a Thorium/Uranium cycle as compared with a gas fired steam- and gas turbine. 6 figs, 9 tabs, 21 refs

Postirradiation examination of HTR fuel

International Nuclear Information System (INIS)

Nabielek, H.; Reitsamer, G.; Kania, M.J.

1986-01-01

Fuel for the High Temperature Reactor (HTR) consists of 1 mm diameter coated particles uniformly distributed in a graphite matrix within a cold-molded 60 mm diameter spherical fuel element. Fuel performance demonstrations under simulated normal operation conditions are conducted in accelerated neutron environments available in Material Test Reactors and in real-time environments such as the Arbeitsgemeinschaft Versuchsreaktor (AVR) Juelich. Postirradiation examinations are then used to assess fuel element behavior and the detailed performance of the coated particles. The emphasis in postirradiation examination and accident testing is on assessment of the capability for fuel elements and individual coated particles to retain fission products and actinide fuel materials. To accomplish this task, techniques have been developed which measures fission product and fuel material distributions within or exterior to the particle: Hot Gas Chlorination - provides an accurate method to measure total fuel material concentration outside intact particles; Profile Electrolytic Deconsolidation - permits determination of fission product distribution along fuel element diameter and retrieval of fuel particles from positions within element; Gamma Spectrometry - provides nondestructive method to measure defect particle fractions based on retention of volatile metallic fission products; Particle Cracking - permits a measure of the partitioning of fission products between fuel kernel and particle coatings, and the derivation of diffusion parameters in fuel materials; Micro Gas Analysis - provides gaseous fission product and reactive gas inventory within free volume of single particles; and Mass-spectrometric Burnup Determination - utilizes isotope dilution for the measurement of heavy metal isotope abundances

Rework of process effluents from the fabrication of HTR fuel

Energy Technology Data Exchange (ETDEWEB)

Lasberg, Ingo; Braehler, Georg [NUKEM Technologies GmbH (Germany); Boyes, David [Pebble Bed Modular Reactor (Pty) Ltd., Centurion (South Africa)

2008-07-01

HTR fuel facilities require the application of several liquid chemicals and accordingly they produce significant amounts of Uranium contaminated/potentially contaminated effluents. The main effluents are (amounts for a 3 t Uranium/a plant): aqueous solutions including tetrahydrofurfuryl alcohol THFA, ammonium hydroxide NH4OH, and ammonium nitrate NH4NO3 (180 m{sup 3}/a), isopropanol IPA/water mixtures (130 m{sup 3}/a); Non-Process Water NPW (300 m{sup 3}/a); methanol (7m{sup 3}/a); additionally off-gas streams, containing ammonia (9 t/a) have to be treated. In an industrial scale facility all such effluents/gases need to be processed for recycling, decontamination prior to release to the environment (as waste or as valuable material). Thermal decomposition is applied to dispose of burnable residues.

Temperature Analysis and Failure Probability of the Fuel Element in HTR-PM

International Nuclear Information System (INIS)

Yang Lin; Liu Bing; Tang Chunhe

2014-01-01

Spherical fuel element is applied in the 200-MW High Temperature Reactor-Pebble-bed Modular (HTR-PM). Each spherical fuel element contains approximately 12,000 coated fuel particles in the inner graphite matrix with a diameter of 50mm to form the fuel zone, while the outer shell with a thickness of 5mm is a fuel-free zone made up of the same graphite material. Under high burnup irradiation, the temperature of fuel element rises and the stress will result in the damage of fuel element. The purpose of this study is to analyze the temperature of fuel element and to discuss the stress and failure probability. (author)

Euratom research and training in generation IV systems with emphasis on V/HTR

International Nuclear Information System (INIS)

Goethem, G. van; Manolatos, P.; Fuetterer, M.

2006-01-01

In this overview paper, the following questions are addressed: (1) What are the challenges facing the European Union nuclear fission research community in the short (today), medium (2010) and long term (2040)? (2) What kind of research and technological development (RTD) does Euratom offer to respond to these challenges, in particular in the area of reactor systems and fuel cycles? In the general debate about energy supply technologies there are challenges of both a scientific and technological (S/T) as well as an economic and political (E/P) nature. Though the Community research programme acts mainly on the former, there is nevertheless important links with Community policy. These not only exist in the specific area of nuclear policy. It is shown in the particular area of nuclear fission, to what extent Euratom research, education and innovation ('Knowledge Triangle: Education, Research, and Innovation') respond to the S/T challenges: (1) sustainability, (2) economics, (3) safety, and (4) proliferation resistance. At the European Commission (EC), the research related to nuclear reactor systems and fuel cycles is principally under the responsibility of the 2 Directorates Generals (DG) DG Research (RTD, located in Brussels), which implements and manages the programme of 'indirect actions', and the DG Joint Research Centre (JRC, headquarters in Brussels and 7 scientific institutes in 5 Member States) which carries out 'direct actions' in their own laboratories. In this HTR-2006 introductory paper, the emphasis is on the indirect and direct actions of the 6 th Euratom research framework programme 2003-2006, FP-6, with special emphasis on V/HTR Generation IV research. (orig.)

Evaluation de la réactivité chimique et de la montée en cohésion au jeune âge des matériaux bitumineux recyclés à froid

OpenAIRE

ODIE, L; NAUDAT, C; BROSSEAUD, Y; BEGHIN, A; PLACIN, F; ECKMANN, B; DELFOSSE, F

2006-01-01

Une des taches du programme de recherche européen SCORE était l'optimisation de la formulation des matériaux bitumineux recyclés à froid. Pour atteindre cet objectif, le LRPC de Saint-Brieuc a développé deux méthodes d'essais qui permettent de mieux appréhender la réactivité chimique entre les fraisats d'enrobé et les émulsions cationiques. La première méthode consiste en une extraction à l'eau acidifiée des fraisats d'enrobés. Le pH de la solution est mesuré tout au long de la procédure d'ex...

Reliability of an HTR-module primary circuit pressure boundary. Influences, sensitivity, and comparison with a PWR

International Nuclear Information System (INIS)

Staat, M.

1995-01-01

The reliability of the HTR-module for electricity and steam generation was analysed for normal operation, as well as accident conditions. The probabilistic fracture mechanics assessment was performed with a modification of the ZERBERUS code on the basis of widely used data. The calculated failure probabilities may thus be compared with similar investigations. The HTR-module primary circuit pressure boundary as a unit showed leak-before-break behaviour in a probabilistic sense, although a break was more probable than a leak for some of its parts.However, the findings may depend greatly on the stochastic data. Therefore a stochastic reference problem is defined and the results are compared with the Japanese round robin on a PWR section. Possible changes of failure probabilities and of the leak-before-break behaviour are discussed for different criteria for the events leading to a leak, and for modifications of the stochastic reference problem such as the inclusion of NDE. The results may be used to identify those stochastic variables which have the greatest influence on the computed failure probabilities, and to perhaps justify further work which would provide more detailed information on these probabilities. Furthermore, there is an obvious need for reduction of the non-statistical reasons for great variations of failure probabilities. (orig.)

Measurement of fission gases released by HTR irradiation samples in the BR 2 reactor (Mol/Belgium)

International Nuclear Information System (INIS)

Koetter, H.; Mueller, H.B.

1975-04-01

During the irradiation of HTR-test fuel (coated particles resp. compacts) the release rate of fission gases is measured automatically. For that purpose the γ-spectrum of the sweep gas is analyzed with respect to the isotopes Xe-133, Xe-135, Xe-135sup(m), Xe-137, Xe-138, Kr-85sup(m), Kr-87, Kr-88, Kr-89. Gas sampling, spectral analysis, data handling and evaluation are controlled by computer. (orig.) [de

Pebble bed reactors simulation using MCNP: The Chinese HTR-10 reactor

Directory of Open Access Journals (Sweden)

SA Hosseini

2013-09-01

Full Text Available   Given the role of Gas-Graphite reactors as the fourth generation reactors and their recently renewed importance, in 2002 the IAEA proposed a set of Benchmarking problems. In this work, we propose a model both efficient in time and resources and exact to simulate the HTR-10 reactor using MCNP-4C code. During the present work, all of the pressing factors in PBM reactor design such as the inter-pebble leakage, fuel particle distribution and fuel pebble packing fraction effects have been taken into account to obtain an exact and easy to run model. Finally, the comparison between the results of the present work and other calculations made at INEEL proves the exactness of the proposed model.

Management system and potential markets for a HTR-GT plant

International Nuclear Information System (INIS)

Crommelin, G.A.K.

1997-01-01

This article will discuss some aspects which could be helpful to execute a HTR-GT study successfully: 1. The preferred type of organisation for such a study; in order to achieve a maximum of support in society and industry, a minimum of through life costing and a maximum of through life support. 2. The lead time needed for such studies i.e. the design, component testing, prototype testing, the required efficiency, the type of energy in quantity and quality, financial targets, controllability, maintainability and reliability. 3. The potential markets for the nuclear gasturbine driven energy plants in the low power range. Analyses of the markets will be explained from the user's point of view on why, when and how, for what purpose, in which power range, as well as how many units per application would be required. (author)

Burnup measurement study and prototype development in HTR-PM

International Nuclear Information System (INIS)

Yan Weihua; Zhang Zhao; Xiao Zhigang; Zhang Liguo

2014-01-01

In a pebble-bed core which employs the multi-pass scheme, it is mandatory to determine the burnup of each pebble after the pebble has been extracted from the core in order to determine whether its design burnup has been reached or whether it has to be reinserted into the core again. The burnup of the fuel pebbles can be determined by measuring the activity of 137 Cs with an HPGe detector because of their good correspondence, which is independent of the irradiation history in the core. Based on experiments and Geant4 simulation, the correction factor between the fuel and calibration source was derived by using the efficiency transfer method. By optimizing spectrum analysis algorithm and parameters, the relative standard deviation of the 137 Cs activity can be still controlled below 3.0% despite of the presence of interfering peaks. On the foundation of the simulation and experiment research, a complete solution for burnup measurement system in HTR-PM is provided. (authors)

Application of the ASME-code-case N 47 to a typical thickwalled HTR-component made of Incoloy 800

International Nuclear Information System (INIS)

Kemter, F.; Schmidt, A.

Several components of the HTR-plant are exposed to temperatures beyond 500 0 C, i.e. within the high-temperature range. The service life of those components is not only limited by fatigue damage but also mainly by creep damage and accumulated inelastic strain. These can be conservatively estimated according to the ASME-Code (high temperature part CC N47) by means of the results of elastic calculations, yet this simplified method to provide evidence often leads to calculated overloads such as the present case of the live steam collector of the steam generator of a HTR. For providing the evidence that the actual loads of the component are within permissible limits, comprehensive inelastic analyses have to be referred to in such a case. The two-dimensional inelastic analysis which is reported here in detail shows that the creep and fatigue failure as well as the inelastic extensions of the live steam collectors accumulated during the service time are below the permissible limit stated in the ASME-Code and failure of those components while used in the reactor can this be excluded. (orig.) [de

An evaluation of the results of the HTR fuel programme conducted in the Dragon reactor experiment

International Nuclear Information System (INIS)

Shepherd, L.R.

1982-01-01

The Dragon Reactor Experiment was used over a period of ten years to investigate the behaviour of HTR fuel elements under realistic service conditions. The purpose of the work was to develop fuel capable of meeting the requirements of commercial power reactors. The studies divided into areas concerned with the mechanical behaviour of the graphite core structure under fast neutron irradiation and the ability of the coated particle fuel to retain fissile products over commercially viable life-cycles. (author)

Technology assessment HTR. Part 4. Power upscaling of High Temperature Reactors

International Nuclear Information System (INIS)

Van Heek, A.I.

1996-06-01

Designs of nuclear reactors can be classified in evolutionary, revolutionary and innovative designs. An innovative design is the High Temperature Reactor (HTR). Introduction of innovative reactors has not been successful until now. Globally, three requirements for this reactors for successful market introduction can be identified: (1) Societal support for nuclear energy, or if separable, for this reactor type, should be repaired; (2) After market introduction the innovative plant must be able to operate economically competitive; and (3) The costs of market introduction of an innovative reactor design must be limited. Until now all reactor designs classified as innovative have not yet been realized. High temperature reactors exist in many different designs. Common features are: helium coolant, graphite moderator and coated particle fuel. The combination of these creates the potential to fulfill the first requirement (public support), and similarly a hurdle to the second requirement (economical operation). All three problems existing in the eyes of the public are addressed, while a high degree of transparency is reached, making the design understandable also by others than nuclear experts. A consequence of designing according to the social support requirement is a limitation of the unit power level. The usual method to make nuclear power plants economically competitive, i.e. just raising the power level (economy of scale) could not be applied anymore. Therefore other means of cost decreasing had to be used: modularization and simplification. These ideas are explained. Since all existing HTRs are currently out of operation, additional experience from two small HTRs under construction at this moment in the Far East will be essential. In the history of HTR designs, an evolutionary path can be identified. The early designs had a philosophy of safety and economics very similar to those of LWR. Modularization was introduced to attain economic viability and the design was

Results of a German probabilistic risk assessment study for the HTR-1160 concept

International Nuclear Information System (INIS)

Fassbender, J.; Kroeger, W.

1981-01-01

The paper reviews ''Accident Initiations and Progression Analysis'' methodology and results which applied to the German equivalent of the HTGR-1160 and German site conditions. The investigation of accidents contributing to risk was concentrated on those event sequences which lead to major release of core inventory or - with less importance - to release of plate-out activity together with coolant gas activity. With regard to release mechanisms severe HTR-accidents were grouped into: a) water ingress events with fission product release due to hydrolysis of defective coated particles and desorption of plate out activity and b) core heating events with fission product release after coated particle failure due to excessive temperatures

Results of a German probabilistic risk assessment study for the HTR-1160 concept

Energy Technology Data Exchange (ETDEWEB)

Fassbender, J.; Kroeger, W. [Kernforschungsanlage Juelich G.m.b.H. (Germany, F.R.). Inst. fuer Nukleare Sicherheitsforschung

1981-01-15

The paper reviews ''Accident Initiations and Progression Analysis'' methodology and results which applied to the German equivalent of the HTGR-1160 and German site conditions. The investigation of accidents contributing to risk was concentrated on those event sequences which lead to major release of core inventory or - with less importance - to release of plate-out activity together with coolant gas activity. With regard to release mechanisms severe HTR-accidents were grouped into: a) water ingress events with fission product release due to hydrolysis of defective coated particles and desorption of plate out activity and b) core heating events with fission product release after coated particle failure due to excessive temperatures.

Multicavity PCPVs for HTR and GCFR systems

International Nuclear Information System (INIS)

Eadie, D.Mc.D.

1979-01-01

There is little extra to report since the presentation of the paper 180/75 Multicavity PCPVs for HTR and GCFR Systems by P.L.T. Morgan and J.N. Bradbury at the International Conference on Experience in the Design, Construction and Operation of Prestressed Concrete Pressure Vessels and Containments for Nuclear Reactors at York, England, in September 1975. The paper presented at the York Conference demonstrated how a particular mode of behaviour could develop in a very local region between the pods and the external wall of a multicavity pressure vessel. Two main points emerge from the paper presented at York - 1. Local analysis for equilibrium of parts of the structure are as important as analysis of the general structural behaviour. With modern computer techniques, in which crack propagation and plasticity may be included, the development of local critical areas can be observed, but the idealisation of the structure has to be sufficiently refined and the cost will be high; 2. Criteria for acceptance of a design must be realistic and must be continually reviewed in the light of the trends of design philosophy. In conclusion, some pictures of model tests demonstrate the physical reality of the mode of failure described in the paper

Moderate mammalian target of rapamycin inhibition induces autophagy in HTR8/SVneo cells via O-linked β-N-acetylglucosamine signaling.

Science.gov (United States)

Zhang, Qiuxia; Na, Quan; Song, Weiwei

2017-10-01

Autophagy, a highly regulated process with a dual role (pro-survival or pro-death), has been implicated in adverse pregnancy outcomes. The aim of this study was to explore the mechanism whereby mammalian target of rapamycin (mTOR) signaling regulates autophagy by modulating protein O-GlcNAcylation in human trophoblasts. HTR8/SVneo cells were incubated in serum-free medium for different time intervals or treated with varying doses of Torin1. Protein expression and cell apoptosis were detected by immunoblotting and flow cytometry, respectively. Short-term serum starvation or slight suppression of mTOR signaling promoted autophagy and decreased apoptosis in HTR8/SVneo cells. Conversely, prolonged serum starvation or excessive inhibition of mTOR reduced autophagy and enhanced cell apoptosis. Both serum starvation and mTOR signaling suppression reduced protein O-GlcNAcylation. Upregulation and downregulation of O-linked β-N-acetylglucosamine (O-GlcNAc) levels attenuated and augmented autophagy, respectively. Moderate mTOR inhibition-induced autophagy was blocked by upregulation of protein O-GlcNAcylation. Furthermore, immunoprecipitation studies revealed that Beclin1 and synaptosome associated protein 29 (SNAP29) could be O-GlcNAcylated, and that slight mTOR inhibition resulted in decreased O-GlcNAc modification of Beclin1 and SNAP29. Notably, we observed an inverse correlation between phosphorylation (Ser15) and O-GlcNAcylation of Beclin1. mTOR signaling inhibition played dual roles in regulating autophagy and apoptosis in HTR8/SVneo cells. Moderate mTOR suppression might induce autophagy via modulating O-GlcNAcylation of Beclin1 and SNAP29. Moreover, the negative interplay between Beclin1 O-GlcNAcylation and phosphorylation (Ser15) may be involved in autophagy regulation by mTOR signaling. © 2017 Japan Society of Obstetrics and Gynecology.

Effect of the type of mineral aggregate on the high-temperature creep of HTR-concrete

International Nuclear Information System (INIS)

Diederichs, U.; Becker, G.

1989-01-01

Within the scope of the research and development work for the prestressed concrete vessel of the HTR 500 High-Temperature Reactor mix design, manufacture as well as mechanical and thermal behavior of the concrete have been comprehensively studied. Of the concrete types analyzed, a basalt concrete showed extremely favorable high-temperature characteristics while a concrete with Rhine gravel was characterized by a good workability. These two types of concrete were subjected to numerous tests, whereby the testing procedures were strongly related to the anticipated combined stress, temperature and moisture conditions in the real structure

Modelling of HTR (High Temperature Reactor Pebble-Bed 10 MW to Determine Criticality as A Variations of Enrichment and Radius of the Fuel (Kernel With the Monte Carlo Code MCNP4C

Directory of Open Access Journals (Sweden)

Hammam Oktajianto

2014-12-01

Full Text Available Gas-cooled nuclear reactor is a Generation IV reactor which has been receiving significant attention due to many desired characteristics such as inherent safety, modularity, relatively low cost, short construction period, and easy financing. High temperature reactor (HTR pebble-bed as one of type of gas-cooled reactor concept is getting attention. In HTR pebble-bed design, radius and enrichment of the fuel kernel are the key parameter that can be chosen freely to determine the desired value of criticality. This paper models HTR pebble-bed 10 MW and determines an effective of enrichment and radius of the fuel (Kernel to get criticality value of reactor. The TRISO particle coated fuel particle which was modelled explicitly and distributed in the fuelled region of the fuel pebbles using a Simple-Cubic (SC lattice. The pebble-bed balls and moderator balls distributed in the core zone using a Body-Centred Cubic lattice with assumption of a fresh fuel by the fuel enrichment was 7-17% at 1% range and the size of the fuel radius was 175-300 µm at 25 µm ranges. The geometrical model of the full reactor is obtained by using lattice and universe facilities provided by MCNP4C. The details of model are discussed with necessary simplifications. Criticality calculations were conducted by Monte Carlo transport code MCNP4C and continuous energy nuclear data library ENDF/B-VI. From calculation results can be concluded that an effective of enrichment and radius of fuel (Kernel to achieve a critical condition was the enrichment of 15-17% at a radius of 200 µm, the enrichment of 13-17% at a radius of 225 µm, the enrichments of 12-15% at radius of 250 µm, the enrichments of 11-14% at a radius of 275 µm and the enrichment of 10-13% at a radius of 300 µm, so that the effective of enrichments and radii of fuel (Kernel can be considered in the HTR 10 MW. Keywords—MCNP4C, HTR, enrichment, radius, criticality 

HTR combustion head end comparison of the shaft furnace and fluidized bed processes

Energy Technology Data Exchange (ETDEWEB)

Boehnert, R.; Kaiser, G.; Pirk, H.; Tillessen, U.

1975-01-15

Two methods are described for the combustion of the graphite of HTR fuel elements, a sufficient description of the principles being given to permit an understanding of the processes. The present state of the technology of the two processes is then compared on the basis of the results obtained at Gulf General Atomic. Finally, the possibilities of further development are examined using a pilot plant designed to deliver a reactor power of 7000 MWe as the basis. The present report is a collection of facts. It contains neither an evaluation nor a recommendation. A summarized comparison of the state of the technology and the possibilities of development is given in tabular form.

HTR-proteus pebble bed experimental program core 4: random packing with a 1:1 moderator-to-fuel pebble ratio

Energy Technology Data Exchange (ETDEWEB)

Bess, John D. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Montierth, Leland M. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sterbentz, James W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Briggs, J. Blair [Idaho National Lab. (INL), Idaho Falls, ID (United States); Gougar, Hans D. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Snoj, Luka [Jozef Stefan Inst. (IJS), Ljubljana (Slovenia); Lengar, Igor [Jozef Stefan Inst. (IJS), Ljubljana (Slovenia); Koberl, Oliver [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

2014-03-01

In its deployment as a pebble bed reactor (PBR) critical facility from 1992 to 1996, the PROTEUS facility was designated as HTR-PROTEUS. This experimental program was performed as part of an International Atomic Energy Agency (IAEA) Coordinated Research Project (CRP) on the Validation of Safety Related Physics Calculations for Low Enriched HTGRs. Within this project, critical experiments were conducted for graphite moderated LEU systems to determine core reactivity, flux and power profiles, reaction-rate ratios, the worth of control rods, both in-core and reflector based, the worth of burnable poisons, kinetic parameters, and the effects of moisture ingress on these parameters. One benchmark experiment was evaluated in this report: Core 4. Core 4 represents the only configuration with random pebble packing in the HTR-PROTEUS series of experiments, and has a moderator-to-fuel pebble ratio of 1:1. Three random configurations were performed. The initial configuration, Core 4.1, was rejected because the method for pebble loading, separate delivery tubes for the moderator and fuel pebbles, may not have been completely random; this core loading was rejected by the experimenters. Cores 4.2 and 4.3 were loaded using a single delivery tube, eliminating the possibility for systematic ordering effects. The second and third cores differed slightly in the quantity of pebbles loaded (40 each of moderator and fuel pebbles), stacked height of the pebbles in the core cavity (0.02 m), withdrawn distance of the stainless steel control rods (20 mm), and withdrawn distance of the autorod (30 mm). The 34 coolant channels in the upper axial reflector and the 33 coolant channels in the lower axial reflector were open. Additionally, the axial graphite fillers used in all other HTR-PROTEUS configurations to create a 12-sided core cavity were not used in the randomly packed cores. Instead, graphite fillers were placed on the cavity floor, creating a funnel-like base, to discourage ordering

HTR-PROTEUS PEBBLE BED EXPERIMENTAL PROGRAM CORE 4: RANDOM PACKING WITH A 1:1 MODERATOR-TO-FUEL PEBBLE RATIO

Energy Technology Data Exchange (ETDEWEB)

John D. Bess; Leland M. Montierth

2013-03-01

In its deployment as a pebble bed reactor (PBR) critical facility from 1992 to 1996, the PROTEUS facility was designated as HTR-PROTEUS. This experimental program was performed as part of an International Atomic Energy Agency (IAEA) Coordinated Research Project (CRP) on the Validation of Safety Related Physics Calculations for Low Enriched HTGRs. Within this project, critical experiments were conducted for graphite moderated LEU systems to determine core reactivity, flux and power profiles, reaction-rate ratios, the worth of control rods, both in-core and reflector based, the worth of burnable poisons, kinetic parameters, and the effects of moisture ingress on these parameters. One benchmark experiment was evaluated in this report: Core 4. Core 4 represents the only configuration with random pebble packing in the HTR-PROTEUS series of experiments, and has a moderator-to-fuel pebble ratio of 1:1. Three random configurations were performed. The initial configuration, Core 4.1, was rejected because the method for pebble loading, separate delivery tubes for the moderator and fuel pebbles, may not have been completely random; this core loading was rejected by the experimenters. Cores 4.2 and 4.3 were loaded using a single delivery tube, eliminating the possibility for systematic ordering effects. The second and third cores differed slightly in the quantity of pebbles loaded (40 each of moderator and fuel pebbles), stacked height of the pebbles in the core cavity (0.02 m), withdrawn distance of the stainless steel control rods (20 mm), and withdrawn distance of the autorod (30 mm). The 34 coolant channels in the upper axial reflector and the 33 coolant channels in the lower axial reflector were open. Additionally, the axial graphite fillers used in all other HTR-PROTEUS configurations to create a 12-sided core cavity were not used in the randomly packed cores. Instead, graphite fillers were placed on the cavity floor, creating a funnel-like base, to discourage ordering

Mechanical Properties and Structures of Pyrolytic Carbon Coating Layer in HTR Coated Particle Fuel

International Nuclear Information System (INIS)

Lee, Young Woo; Kim, Young Min; Kim, Woong Ki; Cho, Moon Sung

2009-01-01

The TRISO(tri-isotropic)-coated fuel particle for a HTR(High Temperature gas-cooled Reactor) has a diameter of about 1 mm, composed of a nuclear fuel kernel and four different outer coating layers, consisting of a buffer PyC (pyrolytic carbon) layer, inner PyC layer, SiC layer, and outer PyC layer with different coating thicknesses following a specific fuel design. While the fuel kernel is a source for a heat generation by a nuclear fission of fissile uranium, each of the four coating layers acts as a different role in view of retaining the generated fission products and the other interactions during an in-reactor service. Among these coating layers, PyC properties are scarcely in agreement among various investigators and the dependency of their changes upon the deposition condition is comparatively large due to their additional anisotropic properties. Although a recent review work has contributed to an establishment of relationship between the material properties and QC measurements, the data on the mechanical properties and structural parameters of PyC coating layers remain still unclearly evaluated. A review work on dimensional changes of PyC by neutron irradiation was one of re-evaluative works recently attempted by the authors. In this work, an attempt was made to analyze and re-evaluate the existing data of the experimental results of the mechanical properties, i.e., Young's modulus and fracture stress, in relation with the coating conditions, density and the BAF (Bacon Anisotropy Factor), an important structural parameter, of PyC coating layers obtained from various experiments performed in the early periods of the HTR coated particle development

Axial temperatures and fuel management models for a HTR system

Energy Technology Data Exchange (ETDEWEB)

Hansen, U

1971-11-12

In the HTR system, there is a large difference in temperature between different parts of the reactor core. The softer neutron spectrum in the upper colder core regions tends to shift the power productions in the fresh fuel upwards. As uranium 235 depletes and plutonium with its higher cross sections in the lower hot regions is built-up, an axial power flattening takes place. These effects have been studied in detail for a single column in an equilibrium environment. The aim of this paper is to relate these findings to a whole reactor core and to investigate the influence of axial temperatures on the overall performance and in particular, the fuel management scheme chosen for the reference design. A further objective has been to calculate the reactivity requirements for different part load conditions and for various daily and weekly load diagrams. As the xenon cross section changes significantly with temperature these investigations are performed for an equilibrium core with due representation of axial temperature zones.

Studies on the effects of the hypothetic accidents in HTR reactors. (phase 1). HSK 1. Pt. 1

International Nuclear Information System (INIS)

Gabriel, H.W.; Redondo, J.A.

1977-09-01

The report is an attempt to outline the possibilities of a quantitative, i.e. objective safety assessment. The basic problem here are the controversial opinions an the term of 'risk'. As long as there is no technically and legally acceptable compromise between the opinion 'risk equals extent of damage' and the probabilistic concept, systems in development must follow both approaches. Using the HTR-1160 as an example, studies on the determination of the maximum possible extent of damage in nuclear power plants have been carried out with a special view to determining the rate of the course of extreme accident combinations. Knowledge on this point helps to quantify the chances to prevent the accident itself as well as the chances to protect the population. One basic assumption is that there are no active safety measures to ameliorate the course of the accident (hypothetic accident chains). Consequence analysis is based on nothing but analytically and experimentally validable data, i.e. 'natural law data' on the failure of passive reactor components. Present findings show that HTR reactors can be designed in such manner that accidents with vicinity dose development velocities above 100 rem/5 h are practically impossible. The time history of dose development velocities in the vicinity can be superposed by the course of possible administrative measures. Risk values can then be assessed with sufficient accuracy. (orig./HP) [de

Studi Awal Desain Pebble Bed Reactor Berbasis Htr-pm Dengan Skema Resirkulasi Bahan Bakar Once-through-then-out

OpenAIRE

Setiadipura, Topan; Pane, Jupiter Sitorus; Zuhair, Zuhair

2016-01-01

STUDI AWAL DESAIN PEBBLE BED REACTOR BERBASIS HTR-PM DENGAN RESIRKULASI BAHAN BAKAR ONCE-THROUGH-THEN-OUT. Reaktor nuklir tipe pebble bed reactor (PBR) adalah salah satu reaktor canggih dengan fitur keselamatan pasif yang kuat. Pada desain tipe ini berpotensi untuk dilakukan kogenerasi yang bermanfaat untuk pengolahan berbagai mineral di berbagai pulau di Indonesia. Operasi PBR dapat lebih disederhanakan dengan menerapkan skema pengisian bahan bakar once-through-then-out (OTTO) dimana bahan b...

Analysis of diffusion process and influence factors in the air ingress accident of the HTR-PM

Energy Technology Data Exchange (ETDEWEB)

Yanhua, Zheng, E-mail: zhengyh@mail.tsinghua.edu.cn; Fubing, Chen; Lei, Shi

2014-05-01

Air ingress, one of the beyond design basis accidents for high temperature gas-cooled reactors, receives high attention during the design of the 250 MW pebble-bed modular high temperature gas-cooled reactor (HTR-PM), because it may result in severe consequence including the corrosion of the fuel element and graphite reflector. The diffusion process and the set-up time of the stable natural convection after the double-ended guillotine break of the hot-gas duct are studied in the paper. On the basis of the preliminary design of the HTR-PM and its DLOCA analysis results, the diffusion process, as well as the influence of the core temperature distribution and the length of the hot-gas duct, is studied with the DIFFLOW code, which adopts a one-dimension variable cross-section diffusion model with fixed wall temperature. To preliminarily estimate the influence of chemical reaction between oxygen and graphite, which will change the gas component of the mixture, the diffusion processes between the He/N{sub 2}, He/O{sub 2}, He/CO and He/CO{sub 2} are calculated, respectively. Furthermore, the code has been improved and the varying wall temperature can be simulated. The more accurate analysis is carried out with the changing temperature distribution from the DLOCA calculation. The analysis shows that there is enough time to adopt appropriate mitigation measures to stop the air ingress and the severe consequence of fuel element damage and large release of fission product can be avoided.

Results and future programme of HTR's study

International Nuclear Information System (INIS)

Mursid Djokolelono; Soedyartomo Soentono

1990-01-01

Study on the application of HTRs for the enhanced oil recovery in the Duri oil field (Sumatra, Indonesia) was performed in 1986/1987. The economic and technological advantages over crude burning option were identified. Crude oil prices, HTR capital costs, discount rates and company's income structure represented dominant parameters. Further sensitivity calculations on important economic parameters were obtained to reflect the condition of 1988. This nuclear option was also incorporated in the energy planning study for the whole of Indonesia using the MARKAL model, and resulted in the conditions of its applicability. The scenarios chosen in this MARKAL study were high and low GDP growth rate, whereas the criteria chosen were the minimum cost with and without a predetermined policy of reduced domestic use of oil. In the high scenario the HTRs as well as the natural gas options could not compete against the low cost boilers with crude-oil fuel. But in the case of reduced domestic oil use the HTRs came out to supplement the crudeburning boilers starting in the sixth five year plan (1994-999), even earlier than the natural gas option. The authors further discuss the industrial environment, in relation to the regional development, the possible local participation, as well as the plan to materialize the merits of this novel application. (author)

Results and future programme of HTR's study

Energy Technology Data Exchange (ETDEWEB)

Djokolelono, Mursid; Soentono, Soedyartomo [National Atomic Energy Agency (Indonesia)

1990-07-01

Study on the application of HTRs for the enhanced oil recovery in the Duri oil field (Sumatra, Indonesia) was performed in 1986/1987. The economic and technological advantages over crude burning option were identified. Crude oil prices, HTR capital costs, discount rates and company's income structure represented dominant parameters. Further sensitivity calculations on important economic parameters were obtained to reflect the condition of 1988. This nuclear option was also incorporated in the energy planning study for the whole of Indonesia using the MARKAL model, and resulted in the conditions of its applicability. The scenarios chosen in this MARKAL study were high and low GDP growth rate, whereas the criteria chosen were the minimum cost with and without a predetermined policy of reduced domestic use of oil. In the high scenario the HTRs as well as the natural gas options could not compete against the low cost boilers with crude-oil fuel. But in the case of reduced domestic oil use the HTRs came out to supplement the crudeburning boilers starting in the sixth five year plan (1994-999), even earlier than the natural gas option. The authors further discuss the industrial environment, in relation to the regional development, the possible local participation, as well as the plan to materialize the merits of this novel application. (author)

Abrasion behavior of graphite pebble in lifting pipe of pebble-bed HTR

Energy Technology Data Exchange (ETDEWEB)

Shen, Ke; Su, Jiageng [Institute of Nuclear and New Energy Technology, Advanced Nuclear Energy Technology Cooperation Innovation Center, The Key Laboratory of Advanced Nuclear Engineering and Safety, Ministry of Education, Beijing 10084 (China); Zhou, Hongbo [Institute of Nuclear and New Energy Technology, Advanced Nuclear Energy Technology Cooperation Innovation Center, The Key Laboratory of Advanced Nuclear Engineering and Safety, Ministry of Education, Beijing 10084 (China); Chinergy Co., LTD., Beijing 100193 (China); Peng, Wei; Liu, Bing [Institute of Nuclear and New Energy Technology, Advanced Nuclear Energy Technology Cooperation Innovation Center, The Key Laboratory of Advanced Nuclear Engineering and Safety, Ministry of Education, Beijing 10084 (China); Yu, Suyun, E-mail: suyuan@tsinghua.edu.cn [Center for Combustion Energy, The Key Laboratory for Thermal Science and Power Engineering, Ministry of Educations, Tsinghua University, Beijing 10084 (China)

2015-11-15

Highlights: • Quantitative determination of abrasion rate of graphite pebbles in different lifting velocities. • Abrasion behavior of graphite pebble in helium, air and nitrogen. • In helium, intensive collisions caused by oscillatory motion result in more graphite dust production. - Abstract: A pebble-bed high-temperature gas-cooled reactor (pebble-bed HTR) uses a helium coolant, graphite core structure, and spherical fuel elements. The pebble-bed design enables on-line refueling, avoiding refueling shutdowns. During circulation process, the pebbles are lifted pneumatically via a stainless steel lifting pipe and reinserted into the reactor. Inevitably, the movement of the fuel elements as they recirculate in the reactor produces graphite dust. Mechanical wear is the primary source of graphite dust production. Specifically, the sources are mechanisms of pebble–pebble contact, pebble–wall (structural graphite) contact, and fuel handling (pebble–metal abrasion). The key contribution to graphite dust production is from the fuel handling system, particularly from the lifting pipe. During pneumatic lift, graphite pebbles undergo multiple collisions with the stainless steel lifting pipe, thereby causing abrasion of the graphite pebbles and producing graphite dust. The present work explored the abrasion behavior of graphite pebble in the lifting pipe by measuring the abrasion rate at different lifting velocities. The abrasion rate of the graphite pebble in helium was found much higher than those in air and nitrogen. This gas environment effect could be explained by either tribology behavior or dynamic behavior. Friction testing excluded the possibility of tribology reason. The dynamic behavior of the graphite pebble was captured by analysis of the audio waveforms during pneumatic lift. The analysis results revealed unique dynamic behavior of the graphite pebble in helium. Oscillation and consequently intensive collisions occur during pneumatic lift, causing

Blocking Epidermal Growth Factor Receptor Signaling in HTR-8/SVneo First Trimester Trophoblast Cells Results in Dephosphorylation of PKBα/AKT and Induces Apoptosis

Directory of Open Access Journals (Sweden)

J. Bolnick

2011-01-01

Full Text Available We identified a major peptide signaling target of EGF/EGFR pathway and explored the consequences of blocking or activating this pathway in the first trimester extravillous trophoblast cells, HTR-8/SVneo. A global analysis of protein phosphorylation was undertaken using novel technology (Kinexus Kinetworks that utilizes SDS-polyacrylamide minigel electrophoresis and multi-lane immunoblotting to permit specific and semiquantitative detection of multiple phosphoproteins. Forty-seven protein phosphorylation sites were queried, and the results reported based on relative phosphorylation at each site. EGF- and Iressa-(gefitinib, ZD1839, an inhibitor of EGFR treated HTR-8/SVneo cells were subjected to immunoblotting and flow cytometry to confirm the phosphoprotein screen and to assess the effects of EGF versus Iressa on cell cycle and apoptosis. EGFR mediates the phosphorylation of important signaling proteins, including PKBα/AKT. This pathway is likely to be central to EGFR-mediated trophoblast survival. Furthermore, EGF treatment induces proliferation and inhibits apoptosis, while Iressa induces apoptosis.

Determination of safety margins for creep loaded primary circuit components in case of loss of pressure accidents of a HTR plant (SR 383)

International Nuclear Information System (INIS)

Breitbach, G.; Ahmed, K.; Over, H.; Schubert, F.; Nickel, H.

1991-10-01

The wall thickness of tubes in high temperature plants must be limited in such a way that pressure differences can not produce unadmissible deformations. For HTR (PNP-Plant) the postulated loss of secondary pressure is one of the considered accidents. In that case the tubes of the heat exchangers are loaded by the outher pressure of the primary coolant. So the risk of a creep collapse is given. The report is related to experimental and theoretical work for the creep collapse phenomena. HTR relevant tube geometries of the high temperature alloys NiCr22Co12Mo (INCONEL 617) and X10NiCrAlTi 32 20 (INCOLOY 800) were tested at temperatures of 900 and 950deg C and outer pressure loads in the range 40 bars. The experimental results are compared with theoretically computed values and discussed. The problem of safety margin is treated. Further, simplified procedures are developed for the estimation of the collapse time. (orig.) [de

Technology Assessment HTR. Part 7. Social support for the introduction of the High Temperature Reactor

International Nuclear Information System (INIS)

De Ruiter, W.

1996-06-01

The safety of nuclear power plants is the main subject in risk analysis and risk perception of nuclear energy. The question is if a substantial increase in safety according to the classic risk analysis will lead to a decrease in the percepted risks of nuclear energy. In this report the uncertainties in existing risk analysis are dealt with. The results of public risk perception studies of nuclear power are then analysed and possible changes in the public risk perception in the case of the introduction of the HTR is dealt with. Results and conclusions are presented. 4 tabs., 71 refs

The influence of wall materials on Cs depositions in HTR coolant loops

International Nuclear Information System (INIS)

Herion, J.

1975-01-01

The basic concepts on the effect of the wall material on the deposition of fission products in high temperature reactor (HTR) coolant loops are developed which include the mechanisms of adsorption, solubility and diffusion. General mathematical interrelations of the Cs-adsorption on technical metals are presented and discussed using experimental data from the literature. Desorption energies and frequency factors are determined from measurements of the electrons' work function of metals in Cs atmosphere from R.G. Wilson using these mathematical interrelations. The solubilities and the diffusion constants of Cs are so small in the few investigated cases (Mo, Ta) that high diffusivity paths must be taken into account. Thermochemical considerations on the influence of gaseous impurities on the deposition behaviour are lacking in reliable data. (orig./LH) [de

Fission-product behaviour during irradiation of TRISO-coated particles in the HFREU1bis experiment - HTR2008-58125

International Nuclear Information System (INIS)

De Groot, S.; Bakker, K.; Barrachin, M.; Dubourg, R.; Kissane, M.

2008-01-01

The irradiation experiment HFR-EU1bis, coordinated by the European Joint Research Centre - Inst. for Energy, was performed in the High Flux Reactor (HFR) at Petten to test five spherical HTR fuel pebbles of former German production with TRISO coated particles in conditions beyond the specifications of current HTR reactor designs (central temperature of 1250 deg. C). In this paper, the behaviour of the fission products (FPs) and kernel micro-structure evolution during the test are investigated. While FP behaviour is a key issue for potential source term evaluation it also determines the evolution of the oxygen potential in the oxide kernel which in turn is important for formation of carbon oxides (amoeba effect and pressurization). Fission-gas release from the kernel can induce additional mechanical loading and finally some FPs (Ag, Cs, Sr) might alter the mechanical integrity of the coatings. This study is based on post- irradiation examinations (ceramography + EPMA) performed both on UO 2 kernels and on coatings. Significant evolutions of the kernel as a function of temperature are shown (grain structure, porosity, size of metallic inclusions). The quality of the ceramography results allows characteristics of the intergranular bubbles in the kernel (and estimation of swelling) to be determined. Remarkable results considering FP release from the kernel have been observed and will be presented. Examples are the significant release of Cs out of the kernel as well as Pd, whereas Zr remains trapped. Mo and Ru are mainly incorporated in metallic precipitates. These observations are interpreted and mechanisms for FP and micro-structural evolutions are proposed. These results are coupled to the results of calculations performed with the mechanistic code MFPR (Module for Fission Product Release) and the thermodynamic database MEPHISTA (Multiphase Equilibria in Fuels via Standard Thermodynamic Analysis). The effect of high flux rate and high temperature on fission gas

Development of a dry-mechanical graphite separation process and elimination of the separated carbon for the reprocessing of spherical HTR fuel elements

International Nuclear Information System (INIS)

Kronschnabel, H.

1982-01-01

Due to the C-14 distribution the separation of the particle-free outer region of the spherical HTR fuel element with subsequent solidification of the separated carbon makes it possible to reduce by half the remaining C-14 inventory in the inner particle region to be further treated. Separation of the particle-free outer region by a newly developed sphere-peeling milling machine, conditioning the graphite into compacts and in-situ cementation into a salt-mine are the basic elements of this head-end process variation. An annual cavern volume of approx. 2000 m 3 will be needed to ultimately store the graphite of the particle-free outer region, which corresponds to a reprocessing capacity of 50 GWsub(e) installed HTR power. The brush-disintegration of the remaining inner particle region and the resulting peel-brush-preparation are capable of separating 95% of the graphite without any heavy metal losses. With the mentioned reprocessing capacity an annual cavern volume of approx. 16.500 m 3 is required. (orig.) [de

Research on vibration properties of auxiliary bearing cage used in HTR-10 GT project

International Nuclear Information System (INIS)

Qin Qingquan; Yang Guojun; Shi Zhengang; Yu Suyuan

2009-01-01

Auxiliary Bearings (ABs) is one of the most important parts in Active Magnetic Bearing (AMB) system, which was used in HTR-10 GT project. This paper uses finite element method to analyze the centrifugal stress and free vibration properties of the cage according to its work condition. And different geometric parameters of the cage that has effects on its vibration performance are discussed. The results show that the highest centrifugal stress is in the middle of the cage side sill. The low odder vibration modes of the cage can be induced when the auxiliary bearings are working. Proper geometric parameters and ball pocket number can enhance the performance of the cage. (authors)

Design Procedure of Graphite Components by ASME HTR Codes

Energy Technology Data Exchange (ETDEWEB)

Kang, Ji-Ho; Jo, Chang Keun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2016-10-15

In this study, the ASME B and PV Code, Subsection HH, Subpart A, design procedure for graphite components of HTRs was reviewed and the differences from metal materials were remarked. The Korean VHTR has a prismatic core which is made of multiple graphite blocks, reflectors, and core supports. One of the design issues is the assessment of the structural integrity of the graphite components because the graphite is brittle and shows quite different behaviors from metals in high temperature environment. The American Society of Mechanical Engineers (ASME) issued the latest edition of the code for the high temperature reactors (HTR) in 2015. In this study, the ASME B and PV Code, Subsection HH, Subpart A, Graphite Materials was reviewed and the special features were remarked. Due the brittleness of graphites, the damage-tolerant design procedures different from the conventional metals were adopted based on semi-probabilistic approaches. The unique additional classification, SRC, is allotted to the graphite components and the full 3-D FEM or equivalent stress analysis method is required. In specific conditions, the oxidation and viscoelasticity analysis of material are required. The fatigue damage rule has not been established yet.

Design Procedure of Graphite Components by ASME HTR Codes

International Nuclear Information System (INIS)

Kang, Ji-Ho; Jo, Chang Keun

2016-01-01

In this study, the ASME B and PV Code, Subsection HH, Subpart A, design procedure for graphite components of HTRs was reviewed and the differences from metal materials were remarked. The Korean VHTR has a prismatic core which is made of multiple graphite blocks, reflectors, and core supports. One of the design issues is the assessment of the structural integrity of the graphite components because the graphite is brittle and shows quite different behaviors from metals in high temperature environment. The American Society of Mechanical Engineers (ASME) issued the latest edition of the code for the high temperature reactors (HTR) in 2015. In this study, the ASME B and PV Code, Subsection HH, Subpart A, Graphite Materials was reviewed and the special features were remarked. Due the brittleness of graphites, the damage-tolerant design procedures different from the conventional metals were adopted based on semi-probabilistic approaches. The unique additional classification, SRC, is allotted to the graphite components and the full 3-D FEM or equivalent stress analysis method is required. In specific conditions, the oxidation and viscoelasticity analysis of material are required. The fatigue damage rule has not been established yet

Status of the HTR programme in France

International Nuclear Information System (INIS)

Ballot, B.; Gauthier, J.C.; Hittner, D.; Lebrun, J.Ph.; Lecomte, M.; Carre, F.; Delbecq, J.M.

2007-01-01

AREVA is convinced that HTR (High Temperature Reactor) is not in competition with large LWRs for electricity generation, and that its actual added value is its potential for addressing cogeneration and industrial process heat production. Therefore AREVA launched in 2004 the ANTARES programme for a pre-conceptual design study, with the support of EDF and together with a large research and development programme needed for the design in close collaboration with Cea. The pre-conceptual phase was finalized end of 2006. The specific feature of AREVA's concept, which distinguishes it from other ones, is its indirect cycle design powering a combined cycle power plant. Several reasons support this design choice, one of the most important being the design flexibility to adapt readily to combined heat and power applications, with a standardised nuclear heat source as independent as possible of the versatile process heat applications with which it is coupled. Standardisation should expedite licensing. In view of the volatility of the costs of fossil fuels, AREVA's choice brings to the large industrial heat applications the fuel cost predictability of nuclear fuel with the efficiency of a high temperature heat source free of greenhouse gases emissions. The reactor module produces 600 MWth which can be split into the required process heat, the remaining power driving an adapted prorated electric plant. Depending on the process heat temperature and power needs, up to 80 % of the nuclear heat is converted into useful energy

Pu and MA Management in Thermal HTR, QUO VADIS? Insights from the Euratom PUMA project

International Nuclear Information System (INIS)

Kuijper, J.C.

2013-01-01

The results of this study demonstrate the excellent plutonium and minor actinide burning capabilities of the high temperature reactor. The largest degree of incineration is attained in the case of an HTR fuelled by pure plutonium fuel as it remains critical at very deep burn-up of the discharged pebbles. Addition of minor actinides to the fuel leads to decrease of the achievable discharge burn-up and therefore smaller fraction of actinides incinerated during reactor operation. The inert-matrix fuel design improves the transmutation performance of the reactor, while the “wallpaper” fuel does not have advantage over the standard fuel design in this respect

Impact of the Improved Resonance Scattering Kernel on HTR Calculations

International Nuclear Information System (INIS)

Becker, B.; Dagan, R.; Broeders, C.H.M.; Lohnert, G.

2008-01-01

The importance of an advanced neutron scattering model for heavy isotopes with strong energy dependent cross sections such as the pronounced resonances of U 238 has been discussed in various publications where the full double differential scattering kernel was derived. In this study we quantify the effect of the new scattering model for specific innovative types of High Temperature Reactor (HTR) systems which commonly exhibit a higher degree of heterogeneity and higher fuel temperatures, hence increasing the importance of the secondary neutron energy distribution. In particular the impact on the multiplication factor (k ∞ ) and the Doppler reactivity coefficient is presented in view of the packing factors and operating temperatures. A considerable reduction of k ∞ (up to 600 pcm) and an increased Doppler reactivity (up to 10%) is observed. An increase of up to 2.3% of the Pu 239 inventory can be noticed at 90 MWd/tHM burnup due to enhanced neutron absorption of U 238 . Those effects are more pronounced for design cases in which the neutron flux spectrum is hardened towards the resolved resonance range. (authors)

Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line.

Science.gov (United States)

Park, Hae-Ryung; Loch-Caruso, Rita

2014-11-15

Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants, and BDE-47 is a prevalent PBDE congener detected in human tissues. Exposure to PBDEs has been linked to adverse pregnancy outcomes in humans. Although the underlying mechanisms of adverse birth outcomes are poorly understood, critical roles for oxidative stress and inflammation are implicated. The present study investigated antioxidant responses in a human extravillous trophoblast cell line, HTR-8/SVneo, and examined the role of nuclear factor E2-related factor 2 (Nrf2), an antioxidative transcription factor, in BDE-47-induced inflammatory responses in the cells. Treatment of HTR-8/SVneo cells with 5, 10, 15, and 20μM BDE-47 for 24h increased intracellular glutathione (GSH) levels compared to solvent control. Treatment of HTR-8/SVneo cells with 20μM BDE-47 for 24h induced the antioxidant response element (ARE) activity, indicating Nrf2 transactivation by BDE-47 treatment, and resulted in differential expression of redox-sensitive genes compared to solvent control. Pretreatment with tert-butyl hydroquinone (tBHQ) or sulforaphane, known Nrf2 inducers, reduced BDE-47-stimulated IL-6 release with increased ARE reporter activity, reduced nuclear factor kappa B (NF-κB) reporter activity, increased GSH production, and stimulated expression of antioxidant genes compared to non-Nrf2 inducer pretreated groups, suggesting that Nrf2 may play a protective role against BDE-47-mediated inflammatory responses in HTR-8/SVneo cells. These results suggest that Nrf2 activation significantly attenuated BDE-47-induced IL-6 release by augmentation of cellular antioxidative system via upregulation of Nrf2 signaling pathways, and that Nrf2 induction may be a potential therapeutic target to reduce adverse pregnancy outcomes associated with toxicant-induced oxidative stress and inflammation. Copyright © 2014 Elsevier Inc. All rights reserved.

VENUS: cold prototype installation of the head-end of the reprocessing of HTR fuel elements. Activity report, 1 July 1976--31 December 1976

Energy Technology Data Exchange (ETDEWEB)

Boehnert, R.; Walter, C.

1977-02-15

The purpose of the VENUS Project is advance planning for the construction of a cold prototype system to incinerate HTR fuel element graphite. The Venus Project is organized into four phases between advance planning and experimental operation, corresponding to the maturity of the work. It is in the advance planning phase. Status of individual studies is given. (LK)

VENUS: cold prototype installation of the head-end of the reprocessing of HTR fuel elements. Activity report, 1 July 1976--31 December 1976

International Nuclear Information System (INIS)

Boehnert, R.; Walter, C.

The purpose of the VENUS Project is advance planning for the construction of a cold prototype system to incinerate HTR fuel element graphite. The Venus Project is organized into four phases between advance planning and experimental operation, corresponding to the maturity of the work. It is in the advance planning phase. Status of individual studies is given

Study on "1"4C content in post-irradiation graphite spheres of HTR-10

International Nuclear Information System (INIS)

Wang Shouang; Pi Yue; Xie Feng; Li Hong; Cao Jianzhu

2014-01-01

Since the production mechanism of the "1"4C in spherical fuel elements was similar to that of fuel-free graphite spheres, in order to obtain the amount of "1"4C in fuel elements and graphite spheres of HTR-10, the production mechanism of the "1"4C in graphite spheres was studied. The production sources of the "1"4C in graphite spheres and fuel elements were summarized, the amount of "1"4C in the post-irradiation graphite spheres was calculated, the decomposition techniques of graphite spheres were compared, and experimental methods for decomposing the graphite spheres and preparing the "1"4C sample were proposed. The results can lay the foundation for further experimental research and provide theoretical calculations for comparison. (authors)

Predictions on an HTR coolant composition after operational experience with experimental reactors

International Nuclear Information System (INIS)

Nieder, R.

1981-01-01

Long-term operational experience of the HTR experimental reactors Dragon (1966 - 1975), Peach Bottom (1967 - 1974) and AVR (since 1967) has yielded a large number of common quantitative and qualitative results about the sources and behaviour of helium impurities in the primary circuits. Additional information has also been obtained from experiments made at the three reactors. The results at the AVR are particularly interesting because the gas outlet temperature can be varied from 770 0 C to 950 0 C when the reactor power is kept constant. Hence they can be studied according to the temperature dependence of all chemical reactions. It should be possible to apply the results from the operating measurements and experiments made at the reactors, in particular the interrelation of the impurity concentrations, to future reactors. The absolute values of these impurity concentrations are obtained first and foremost by the corresponding helium purification constants

The presence of both serotonin 1A receptor (HTR1A and dopamine transporter (DAT1 gene variants increase the risk of borderline personality disorder

Directory of Open Access Journals (Sweden)

Peter R Joyce

2014-01-01

Full Text Available Dysfunction in the dopaminergic and serotonergic neurotransmitter systems has been demonstrated to be important in the aetiology of Borderline personality disorder (BPD. We investigated the relationship of two BPD risk factors, the HTR1A promoter polymorphism -1019C>G (rs6295 and the DAT1 repeat allele, with BPD in a major depressive disorder cohort of 367 patients. Out-patients with major depressive disorder were recruited for two treatment trials and assessed for personality disorders, including BPD. DNA samples were collected and the rs6295 polymorphism was detected with a TaqMan® assay. The DAT1 repeat allele was genotyped using a modified PCR method. The impact of polymorphisms on BPD was statistically analysed using uncontrolled logistic and multiple logistic regression models. BPD patients had higher frequencies of the DAT1 9,9 (OR=2.67 and 9,10 (OR=3.67 genotypes and also those homozygous HTR1A G allele (OR=2.03. No significant interactions between HTR1A and DAT1 genotypes, were observed; however, an increased risk of BPD was observed for those patients who were either 9,10; G,G (OR=6.64 and 9,9; C,G (OR=5.42. Furthermore, the odds of BPD in patients exhibiting high-risk variants of these two genes differed from those of patients in low-risk groups by up to a factor of 9. Our study provides evidence implicating the importance of the serotonergic and dopaminergic systems in BPD and that the interaction between genes from different neurotransmitters may play a role in the susceptibility to BPD.

Studies for the layout and technical conception of a two-circuit HTR power plant of 600 MWsub(el) under public utilizer aspects

International Nuclear Information System (INIS)

Schuetten, R.

1981-01-01

In this study concerning conceptions for a nuclear power plant of 600 MWsub(el) with high-temperature reactor a conception for a HTR-nuclear power plant of 600 MWsub(el) to be built in the Federal Republic of Germany in future is developed on the basis of operating experience with the 15-MW-AVR-experimental nuclear power plant, the construction of the THTR-300 nuclear power plant and the gas-cooled reactors of English, French and American origin. This report gives a survey of the most important findings and the requirements on behalf of the public utilities for a nuclear power plant with high-temperature reactor with the dimensions of 600 MWsub(el). The examination of the utilities basic requirements for a power plant and the experience made during the licensing procedure led to this technical and safety conception for a HTR nuclear power plant with spherical fuel elements. In addition, the questions of the possibility of recurrent tests and of repairing safety components and also the future shut-down of the power plant, which are important for the public utilities, are examined. (orig./GL) [de

The general formulation and practical calculation of the diffusion coefficient in a lattice containing cavities; Formulation generale et calcul pratique du coefficient de diffusion dans un reseau comportant des cavites

Energy Technology Data Exchange (ETDEWEB)

Benoist, P [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1959-07-01

The calculation of diffusion coefficients in a lattice necessitates the knowledge of a correct method of weighting the free paths of the different constituents. An unambiguous definition of this weighting method is given here, based on the calculation of leakages from a zone of a reactor. The formulation obtained, which is both simple and general, reduces the calculation of diffusion coefficients to that of collision probabilities in the different media; it reveals in the expression for the radial coefficient the series of the terms of angular correlation (cross terms) recently shown by several authors. This formulation is then used to calculate the practical case of a classical type of lattice composed of a moderator and a fuel element surrounded by an empty space. Analytical and numerical comparison of the expressions obtained with those inferred from the theory of BEHRENS shows up the importance of several new terms some of which are linked with the transparency of the fuel element. Cross terms up to the second order are evaluated. A practical formulary is given at the end of the paper. (author) [French] Le calcul des coefficients de diffusion dans un reseau suppose la connaissance d'un mode de ponderation correct des libres parcours des differents constituants. On definit ici sans ambiguite ce mode de ponderation a partir du calcul des fuites hors d'une zone de reacteur. La formulation obtenue, simple et generale, ramene le calcul des coefficients de diffusion a celui des probabilites de collision dans les differents milieux; elle fait apparaitre dans l'expression du coefficient radial la serie des termes de correlation angulaire (termes rectangles), mis en evidence recemment par plusieurs auteurs. Cette formulation est ensuite appliquee au calcul pratique d'un reseau classique, compose d'un moderateur et d'un element combustible entoure d'une cavite; la comparaison analytique et numerique des expressions obtenues avec celles deduites de la theorie de BEHRENS

A putatively functional polymorphism in the HTR2C gene is associated with depressive symptoms in white females reporting significant life stress.

Directory of Open Access Journals (Sweden)

Beverly H Brummett

Full Text Available Psychosocial stress is well known to be positively associated with subsequent depressive symptoms. Cortisol response to stress may be one of a number of biological mechanisms that links psychological stress to depressive symptoms, although the precise causal pathway remains unclear. Activity of the x-linked serotonin 5-HTR2C receptor has also been shown to be associated with depression and with clinical response to antidepressant medications. We recently demonstrated that variation in a single nucleotide polymorphism on the HTR2C gene, rs6318 (Ser23Cys, is associated with different cortisol release and short-term changes in affect in response to a series of stress tasks in the laboratory. Based on this observation, we decided to examine whether rs6318 might moderate the association between psychosocial stress and subsequent depressive symptoms. In the present study we use cross-sectional data from a large population-based sample of young adult White men (N = 2,366 and White women (N = 2,712 in the United States to test this moderation hypothesis. Specifically, we hypothesized that the association between self-reported stressful life events and depressive symptoms would be stronger among homozygous Ser23 C females and hemizygous Ser23 C males than among Cys23 G carriers. In separate within-sex analyses a genotype-by-life stress interaction was observed for women (p = .022 but not for men (p = .471. Homozygous Ser23 C women who reported high levels of life stress had depressive symptom scores that were about 0.3 standard deviations higher than female Cys23 G carriers with similarly high stress levels. In contrast, no appreciable difference in depressive symptoms was observed between genotypes at lower levels of stress. Our findings support prior work that suggests a functional SNP on the HTR2C gene may confer an increased risk for depressive symptoms in White women with a history of significant life stress.

Monte carlo calculation of the neutron effective dose rate at the outer surface of the biological shield of HTR-10 reactor

International Nuclear Information System (INIS)

Remetti, Romolo; Andreoli, Giulio; Keshishian, Silvina

2012-01-01

Highlights: ► We deal with HTR-10, that is a helium-cooled graphite-moderated pebble bed reactor. ► We carried out Monte Carlo simulation of the core by MCNP5. ► Extensive use of MCNP5 variance reduction methods has been done. ► We calculated the trend of neutron flux within the biological shield. ► We calculated neutron effective dose at the outer surface of biological shield. - Abstract: Research on experimental reactors, such as HTR-10, provide useful data about potentialities of very high temperature gas-cooled reactors (VHTR). The latter is today rated as one of the six nuclear reactor types involved in the Generation-IV International Forum (GIF) Initiative. In this study, the MCNP5 code has been employed to evaluate the neutron radiation trend vs. the biological shield's thickness and to calculate the neutron effective dose rate at the outer surface. The reactor's geometry has been completely modeled by means of lattices and universes provided by MCNP, even though some approximations were required. Monte Carlo calculations have been performed by means of a simple PC and, as a consequence, in order to obtain acceptable run times, it was made an extensive recourse to variance reduction methods.

BMP-2, hypoxia, and COL1A1/HtrA1 siRNAs favor neo-cartilage hyaline matrix formation in chondrocytes.

Science.gov (United States)

Ollitrault, David; Legendre, Florence; Drougard, Carole; Briand, Mélanie; Benateau, Hervé; Goux, Didier; Chajra, Hanane; Poulain, Laurent; Hartmann, Daniel; Vivien, Denis; Shridhar, Vijayalakshmi; Baldi, Alfonso; Mallein-Gerin, Frédéric; Boumediene, Karim; Demoor, Magali; Galera, Philippe

2015-02-01

Osteoarthritis (OA) is an irreversible pathology that causes a decrease in articular cartilage thickness, leading finally to the complete degradation of the affected joint. The low spontaneous repair capacity of cartilage prevents any restoration of the joint surface, making OA a major public health issue. Here, we developed an innovative combination of treatment conditions to improve the human chondrocyte phenotype before autologous chondrocyte implantation. First, we seeded human dedifferentiated chondrocytes into a collagen sponge as a scaffold, cultured them in hypoxia in the presence of a bone morphogenetic protein (BMP), BMP-2, and transfected them with small interfering RNAs targeting two markers overexpressed in OA dedifferentiated chondrocytes, that is, type I collagen and/or HtrA1 serine protease. This strategy significantly decreased mRNA and protein expression of type I collagen and HtrA1, and led to an improvement in the chondrocyte phenotype index of differentiation. The effectiveness of our in vitro culture process was also demonstrated in the nude mouse model in vivo after subcutaneous implantation. We, thus, provide here a new protocol able to favor human hyaline chondrocyte phenotype in primarily dedifferentiated cells, both in vitro and in vivo. Our study also offers an innovative strategy for chondrocyte redifferentiation and opens new opportunities for developing therapeutic targets.

Final Report on Utilization of TRU TRISO Fuel as Applied to HTR Systems Part I: Pebble Bed Reactors

Energy Technology Data Exchange (ETDEWEB)

Brian Boer; Abderrafi M. Ougouag

2011-03-01

significant failure is to be expected for the reference fuel particle during normal operation. It was found, however, that the sensitivity of the coating stress to the CO production in the kernel was large. The CO production is expected to be higher in DB fuel than in UO2 fuel, but its exact level has a high uncertainty. Furthermore, in the fuel performance analysis transient conditions were not yet taken into account. The effort of this task in FY 2010 has focused on the optimization of the core to maximize the pebble discharge burnup level, while retaining its inherent safety characteristics. Using generic pebble bed reactor cores, this task will perform physics calculations to evaluate the capabilities of the pebble bed reactor to perform utilization and destruction of LWR used-fuel transuranics. The task will use established benchmarked models, and will introduce modeling advancements appropriate to the nature of the fuel considered (high transuranic [TRU] content and high burn-up). Accomplishments of this work include: •Core analysis of a HTR-MODULE design loaded with Deep-Burn fuel. •Core analysis of a HTR-MODULE design loaded with Deep-Burn fuel and Uranium. •Core analysis of a HTR-MODULE design loaded with Deep-Burn fuel and Modified Open Cycle Components. •Core analysis of a HTR-MODULE design loaded with Deep-Burn fuel and Americium targets.

Final Report on Utilization of TRU TRISO Fuel as Applied to HTR Systems Part I: Pebble Bed Reactors

International Nuclear Information System (INIS)

Boer, Brian; Ougouag, Abderrafi M.

2011-01-01

failure is to be expected for the reference fuel particle during normal operation. It was found, however, that the sensitivity of the coating stress to the CO production in the kernel was large. The CO production is expected to be higher in DB fuel than in UO2 fuel, but its exact level has a high uncertainty. Furthermore, in the fuel performance analysis transient conditions were not yet taken into account. The effort of this task in FY 2010 has focused on the optimization of the core to maximize the pebble discharge burnup level, while retaining its inherent safety characteristics. Using generic pebble bed reactor cores, this task will perform physics calculations to evaluate the capabilities of the pebble bed reactor to perform utilization and destruction of LWR used-fuel transuranics. The task will use established benchmarked models, and will introduce modeling advancements appropriate to the nature of the fuel considered (high transuranic (TRU) content and high burn-up). Accomplishments of this work include: (1) Core analysis of a HTR-MODULE design loaded with Deep-Burn fuel. (2) Core analysis of a HTR-MODULE design loaded with Deep-Burn fuel and Uranium. (3) Core analysis of a HTR-MODULE design loaded with Deep-Burn fuel and Modified Open Cycle Components. (4) Core analysis of a HTR-MODULE design loaded with Deep-Burn fuel and Americium targets.

Thorium utilisation in a small long-life HTR. Part III: Composite-rod fuel blocks

Energy Technology Data Exchange (ETDEWEB)

Verrue, Jacques, E-mail: jacques.verrue@polytechnique.org [Delft University of Technology, Reactor Institute Delft, Mekelweg 15, 2629 JB Delft (Netherlands); École Polytechnique (Member of ParisTech), 91128 Palaiseau Cedex (France); Ding, Ming, E-mail: dingm2005@gmail.com [Delft University of Technology, Reactor Institute Delft, Mekelweg 15, 2629 JB Delft (Netherlands); Harbin Engineering University, Nantong Street 145, 150001 Harbin (China); Kloosterman, Jan Leen, E-mail: j.l.kloosterman@tudelft.nl [Delft University of Technology, Reactor Institute Delft, Mekelweg 15, 2629 JB Delft (Netherlands)

2014-02-15

Highlights: • Composite-rod fuel blocks are proposed for a small block-type HTR. • An axial separation of fuel compacts is the most important feature. • Three patterns are presented to analyse the effects of the spatial distribution. • The spatial distribution has a large influence on the neutron spectrum. • Composite-rod fuel blocks reach a reactivity swing less than 4%. - Abstract: The U-Battery is a small long-life high temperature gas-cooled reactor (HTR) with power of 20 MWth. In order to increase its lifetime and diminish its reactivity swing, the concept of composite-rod fuel blocks with uranium and thorium was investigated. Composite-rod fuel blocks feature a specific axial separation between UO{sub 2} and ThO{sub 2} compacts in fuel rods. The design parameters, investigated by SCALE 6, include the number and spatial distribution of fuel compacts within the rods, the enrichment of uranium, the radii of fuel kernels and fuel compacts, and the packing fractions of uranium and thorium TRISO particles. The analysis shows that a lower moderation ratio and a larger inventory of heavy metals results in a lower reactivity swing. The optimal atomic carbon-to-heavy metal ratio depends on the mass fraction of U-235 and is commonly in the 160–200 range. The spatial distribution of the fuel compacts within the fuel rods has a large influence on the energy spectrum in each fuel compact and thus on the beginning-of-life reactivity and the reactivity swing. At end-of-life, the differences caused by the spatial distribution of the fuel compacts are smaller due to the fissions of U-233 in the ThO{sub 2} fuel compacts. This phenomenon enables to design fuel blocks with a very low reactivity swing, down to less than 4% in a 10-year lifetime. Among three types of thorium fuelled U-Battery blocks, the composite-rod fuel block achieves the highest end-of-life reactivity and the lowest reactivity swing.

Seismic analysis, support design and stress calculation of HTR-PM transport and conversion devices

International Nuclear Information System (INIS)

Zhang Zheyu; Yuan Chaolong; Zhang Haiquan; Nie Junfeng

2012-01-01

Background: The transport and conversion devices are important guarantees for normal operation of HTR-PM fuel handling system in normal and fault conditions. Purpose: A conflict of devices' support design needs to be solved. The flexibility of supports is required because of pipe thermal expansion displacement, while the stiffness is also required because of large devices quality and eccentric distance. Methods: In this paper, the numerical simulation was employed to analyze the seismic characteristics and optimize the support program, Under the chosen support program, the stress calculation of platen support bracket was designed by solidworks software. Results: The supports solved the conflict between the flexibility and stiffness requirements. Conclusions: Therefore, it can ensure the safety of transport and conversion devices and the supports in seismic conditions. (authors)

Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line

International Nuclear Information System (INIS)

Park, Hae-Ryung; Loch-Caruso, Rita

2014-01-01

Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants, and BDE-47 is a prevalent PBDE congener detected in human tissues. Exposure to PBDEs has been linked to adverse pregnancy outcomes in humans. Although the underlying mechanisms of adverse birth outcomes are poorly understood, critical roles for oxidative stress and inflammation are implicated. The present study investigated antioxidant responses in a human extravillous trophoblast cell line, HTR-8/SVneo, and examined the role of nuclear factor E2-related factor 2 (Nrf2), an antioxidative transcription factor, in BDE-47-induced inflammatory responses in the cells. Treatment of HTR-8/SVneo cells with 5, 10, 15, and 20 μM BDE-47 for 24 h increased intracellular glutathione (GSH) levels compared to solvent control. Treatment of HTR-8/SVneo cells with 20 μM BDE-47 for 24 h induced the antioxidant response element (ARE) activity, indicating Nrf2 transactivation by BDE-47 treatment, and resulted in differential expression of redox-sensitive genes compared to solvent control. Pretreatment with tert-butyl hydroquinone (tBHQ) or sulforaphane, known Nrf2 inducers, reduced BDE-47-stimulated IL-6 release with increased ARE reporter activity, reduced nuclear factor kappa B (NF-κB) reporter activity, increased GSH production, and stimulated expression of antioxidant genes compared to non-Nrf2 inducer pretreated groups, suggesting that Nrf2 may play a protective role against BDE-47-mediated inflammatory responses in HTR-8/SVneo cells. These results suggest that Nrf2 activation significantly attenuated BDE-47-induced IL-6 release by augmentation of cellular antioxidative system via upregulation of Nrf2 signaling pathways, and that Nrf2 induction may be a potential therapeutic target to reduce adverse pregnancy outcomes associated with toxicant-induced oxidative stress and inflammation. - Highlights: • BDE-47 stimulated ARE reporter activity and GSH production. • BDE-47 resulted in differential

Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line

Energy Technology Data Exchange (ETDEWEB)

Park, Hae-Ryung, E-mail: heaven@umich.edu; Loch-Caruso, Rita

2014-11-15

Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants, and BDE-47 is a prevalent PBDE congener detected in human tissues. Exposure to PBDEs has been linked to adverse pregnancy outcomes in humans. Although the underlying mechanisms of adverse birth outcomes are poorly understood, critical roles for oxidative stress and inflammation are implicated. The present study investigated antioxidant responses in a human extravillous trophoblast cell line, HTR-8/SVneo, and examined the role of nuclear factor E2-related factor 2 (Nrf2), an antioxidative transcription factor, in BDE-47-induced inflammatory responses in the cells. Treatment of HTR-8/SVneo cells with 5, 10, 15, and 20 μM BDE-47 for 24 h increased intracellular glutathione (GSH) levels compared to solvent control. Treatment of HTR-8/SVneo cells with 20 μM BDE-47 for 24 h induced the antioxidant response element (ARE) activity, indicating Nrf2 transactivation by BDE-47 treatment, and resulted in differential expression of redox-sensitive genes compared to solvent control. Pretreatment with tert-butyl hydroquinone (tBHQ) or sulforaphane, known Nrf2 inducers, reduced BDE-47-stimulated IL-6 release with increased ARE reporter activity, reduced nuclear factor kappa B (NF-κB) reporter activity, increased GSH production, and stimulated expression of antioxidant genes compared to non-Nrf2 inducer pretreated groups, suggesting that Nrf2 may play a protective role against BDE-47-mediated inflammatory responses in HTR-8/SVneo cells. These results suggest that Nrf2 activation significantly attenuated BDE-47-induced IL-6 release by augmentation of cellular antioxidative system via upregulation of Nrf2 signaling pathways, and that Nrf2 induction may be a potential therapeutic target to reduce adverse pregnancy outcomes associated with toxicant-induced oxidative stress and inflammation. - Highlights: • BDE-47 stimulated ARE reporter activity and GSH production. • BDE-47 resulted in differential

Safety study for HTR conceptual designs under German siting conditions. Phase I B, specialized volume I

International Nuclear Information System (INIS)

1982-08-01

The basic methodology for determining sequences of events and their frequencies (events and fault trees) does not differ significantly from that of other risk studies. This applies analogously to the treatment of statistical data uncertainties and the description of results in the form of expected value with uncertainty factor. System unavailabilities are determined by means of failure rates, most of which originate from the German Risk Study, and consecutive test intervals. Unlike in other risk studies, common mode failures of components of the same kind are being considered by a mostly 10% fraction of the overall failure of the multi-train system (β-factor). A multitude of planned or unplanned operator actions are identified in the study. They are assessed using models from AIPA and according to WASH-1400. HTR-specific aspects allow mitigating operator actions in the range of days, which are approximately covered by subjective estimates, and extensive reversibility of human errors. British experience with gas-cooled reactors proved to be useful for HTR-specific components. Rates of 0.2 to 1 for small leaks and 1.5 x 10 -3 per reactor-year for larger leaks (tube ruptures) are derived on the basis of 2000 steam generator operating years. Failures of the main blowers (0.1 per blower-year) are covered by other transient events. The behaviour of structural components is of great significance for the progression of core heatup accidents. The liner of the reactor pressure vessel and the concrete located behind will fail over a large area due to decreasing strength at temperatures above 800 0 C. A rupture of closure plugs may be virtually precluded. This also applies to a failure of the reactor containment at internal design pressure. The ultimate strength will only be reached at pressures of more than 14 bar. (orig.) [de

Post-irradiation examination of a 13000C-HTR fuel experiment Project J 96.M3

International Nuclear Information System (INIS)

Bueger, J. de; Roettger, H.

1977-01-01

A large variety of loose coated fuel particles have been irradiated in the BR2 at Mol/Belgium at temperatures between 1200 0 C and 1400 0 C and up to a fast neutron fluence of 1.2x1022 cm -2 (E>0.1 MeV) as a Euratom sponsored experiment for the advanced testing of HTR fuel. The specimens have been provided by Belgonucleaire and the Dragon Project. A short description of the experiment as well as the results of post-irradiation examination mainly carried out at Petten (N.H.), The Netherlands, are presented here. The post-irradiation examination has shown that the required performance can be achieved by a number of the tested fuel specimens without serious damage

The lithium-lithium hydride process for the production of hydrogen: comparison of two concepts for 950 and 1300 deg C HTR helium outlet temperature

International Nuclear Information System (INIS)

Oertel, M.; Weirich, W.; Kuegler, B.; Luecke, L.; Pietsch, M.; Winkelmann, U.

1987-01-01

The lithium-lithium hydride process serves to generate hydrogen from water efficiently, using the high temperature heat of a nuclear reactor. Thermodynamic analyses show that hydrogen can be produced with an overall thermal efficiency of 48% at conventional HTR outlet temperatures of 950 0 C. Assuming helium heat of 1300 0 C, 56% overall thermal efficiency can be achieved. (author)

Actual characteristics study on HTR-10GT coupling with direct gas turbine cycle

International Nuclear Information System (INIS)

Peng Xuechuang; Zhu Shutang; Wang Jie

2005-01-01

Compared with a plant of steam turbine cycle, a HTGR plant with direct gas turbine cycle has a higher thermal efficiency. A lot of investigations on the characteristics of HTR-10GT, which is the reactor studying project of Tsinghua University, have been carried out, however, all of them are based on the theoretical Brayton Cycle which neglects many actual conditions, such as leakage, pressure loss and so on. For engineering practices, leakage is an unavoidable problem. The difference of the location and capacity of leakage will directly influence the working medium's thermoparameters and lead to fall of the cycle efficiency. The present study is focused on the performance of an actual Brayton cycle with practical conditions of leakage. The present study which based on building the physical and mathematical model of the leakage, aims to study the actual characteristics of the direct gas turbine circle. (authors)

Status of IAEA international data base on irradiated graphite properties with respect to HTR engineering issues

International Nuclear Information System (INIS)

Hacker, P.J.; Haag, G.

2002-01-01

The International Database on Irradiated Nuclear Graphite Properties contains data on the physical, chemical, mechanical and other relevant properties of graphites. Its purpose is to provide a platform that makes these properties accessible to approved users in the fields of nuclear power, nuclear safety and other nuclear science and technology applications. The database is constructed using Microsoft Access 97 software and has a controlled distribution by CD ROM to approved users. This paper describes the organisation and management of the database through administrative arrangements approved by the IAEA. It also outlines the operation of the database. The paper concludes with some remarks upon and illustrations of the usefulness of the database for the design and operation of HTR. (authors)

Gamma dose rate estimation and operation management suggestions for decommissioning the reactor pressure vessel of HTR-PM

Energy Technology Data Exchange (ETDEWEB)

Sheng Fang; Hong Li; Jianzhu Cao; Wenqian Li; Feng Xie; Jiejuan Tong [Institute of Nuclear and New Energy Technology, Tsinghua, University, Beijing (China)

2013-07-01

China is now designing and constructing a high temperature gas cooled reactor-pebble bed module (HTR-PM). In order to investigate the future decommissioning approach and evaluate possible radiation dose, gamma dose rate near the reactor pressure vessel was calculated for different cooling durations using QAD-CGA program. The source term of this calculation was provided by KORIGEN program. Based on the calculated results, the spatial distribution and temporal changes of gamma dose rate near reactor pressure vessel was systematically analyzed. A suggestion on planning decommissioning operation of reactor pressure vessel of HTRPM was given based on calculated dose rate and the Chinese Standard GB18871-2002. (authors)

Perspectives for the french R and D program for high and very high temperature reactors - HTR2008-58172

International Nuclear Information System (INIS)

Yvon, P.; Hittner, D.; Delbecq, J. M.

2008-01-01

A R and D programme has been launched addressing the needs of the development of an indirect cycle flexible modular HTR operating at 850 deg. C for electricity generation and/or heat production for industrial processes. In the frame of this program, several significant technical challenges required to demonstrate the viability and performance of the system have been successfully addressed. Design and safety analysis needed the development of computational tools, therefore reactor physics, and thermo-fluid dynamics codes have been developed and are now in the process of being validated in the frame of international code-to-code and code to experiment benchmarks. Most importantly, the performance of the HTR/VHTR fuel identified as TRISO-coated particle must prove to be excellent in operating as well as accidental conditions. A manufacturing and quality control process has been developed and now fuel qualification based on irradiation and heating safety tests is being prepared on the basis of irradiation programs in France and in the frame of the GENERATION IV International Forum (GIF) as well as the development of fuel behaviour models including performance data, failure particle prediction and long-term integrity of the coating. Material and component technologies have been investigated in normal and accident conditions for V/HTR objectives. Significant progress has been made for vessel structures and reactor core structural elements. Major challenges still lie ahead for plate type compact intermediate heat exchangers, especially at temperatures above 850 deg. C, but an alternative solution with helical tubes is also being developed. In order to demonstrate that materials have adequate performance over long service life under impure helium environment and constraints, the research programme focuses on microstructural and mechanical property data, long-term irradiation behaviour, corrosion, modelling and codification of design rules as well as qualification of

The "RESEAU MATER": An efficient infection control for endometritis, but not for urinary tract infection after vaginal delivery.

Science.gov (United States)

Ayzac, Louis; Caillat-Vallet, Emmanuelle; Girard, Raphaële; Berland, Michel

"RESEAU MATER" is useful to monitor nosocomial infections in maternity and contributes to the decreasing trend of it, since its implementation. Specifically, this network demonstrates its efficiency in the control of endometritis following vaginal deliveries, but not in the control of urinary tract infections. The aim of this study is to determine whether the difference between the control of endometritis and of urinary tract infection could be explained by an unsuitable regression model or by an unsuitable care policy concerning urinary cares. This study includes (1) the analysis of historic data of the network and (2) the description of French guidelines for maternity cares and available evaluations, concerning endometritis and urinary tract infection prevention. Univariate and multivariate odds ratios (ORs) were calculated for the total study period of 1999-2013, for these infections and their risk factors. The endometritis frequency is decreasing, in association with no significant evolution of associated risk factors, but urinary tract infection frequency is constant, in association with a increasing trend of its risk factors such as intermittent catheterization and epidural analgesia. In French guidelines, all preventive measures against endometritis are clearly broadcasted by all field operators, and repeated audits have reinforced the control of their application. But preventive measures against urinary tract infection seem to be broadcasted exclusively in the circle of infection prevention agencies and not in the obstetrics societies or in the Health Ministry communication. Urinary tract infection prevention requires a clearer public and professional policy in favor of a more efficient urinary cares, with a specific target to maternity. Copyright © 2016 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.

Benchmark Evaluation of HTR-PROTEUS Pebble Bed Experimental Program

International Nuclear Information System (INIS)

Bess, John D.; Montierth, Leland; Köberl, Oliver

2014-01-01

Benchmark models were developed to evaluate 11 critical core configurations of the HTR-PROTEUS pebble bed experimental program. Various additional reactor physics measurements were performed as part of this program; currently only a total of 37 absorber rod worth measurements have been evaluated as acceptable benchmark experiments for Cores 4, 9, and 10. Dominant uncertainties in the experimental keff for all core configurations come from uncertainties in the 235 U enrichment of the fuel, impurities in the moderator pebbles, and the density and impurity content of the radial reflector. Calculations of k eff with MCNP5 and ENDF/B-VII.0 neutron nuclear data are greater than the benchmark values but within 1% and also within the 3σ uncertainty, except for Core 4, which is the only randomly packed pebble configuration. Repeated calculations of k eff with MCNP6.1 and ENDF/B-VII.1 are lower than the benchmark values and within 1% (~3σ) except for Cores 5 and 9, which calculate lower than the benchmark eigenvalues within 4σ. The primary difference between the two nuclear data libraries is the adjustment of the absorption cross section of graphite. Simulations of the absorber rod worth measurements are within 3σ of the benchmark experiment values. The complete benchmark evaluation details are available in the 2014 edition of the International Handbook of Evaluated Reactor Physics Benchmark Experiments

Thorium utilization in a small long-life HTR. Part II: Seed-and-blanket fuel blocks

Energy Technology Data Exchange (ETDEWEB)

Ding, Ming, E-mail: dingming@hrbeu.edu.cn [Delft University of Technology, Reactor Institute Delft, Mekelweg 15, 2629 JB Delft (Netherlands); Harbin Engineering University, Nantong Street 145, 150001 Harbin (China); Kloosterman, Jan Leen [Delft University of Technology, Reactor Institute Delft, Mekelweg 15, 2629 JB Delft (Netherlands)

2014-02-15

Highlights: • Seed-and-blanket (S and B) fuel blocks are proposed for a small block-type HTR. • S and B fuel blocks consist of a seed region (UO{sub 2}) and a blanket region (ThO{sub 2}). • The neutronic performance of S and B fuel blocks are analyzed using SCALE 6. • Three S and B fuel blocks with a reactivity swing of 0.1 Δk are recommended. • S and B fuel blocks are compared with thorium MOX fuel blocks. - Abstract: In order to utilize thorium in high temperature gas-cooled reactors (HTRs), the concept of seed-and-blanket (S and B) fuel block is introduced into the U-Battery, which is a long-life block-type HTR with a thermal power of 20 MWth. A S and B fuel block consists of a seed region with uranium in the center, and a blanket region with thorium. The neutronic performance, such as the multiplication factor, conversion ratio and reactivity swing, of a typical S and B fuel block was investigated by SCALE 6.0 by parametric analysis of the composition parameters and geometric parameters of the fuel block for the U-Battery application. Since the purpose of U-235 in the S and B fuel block is to ignite the fission reactions in the fuel block, 20% enriched uranium is recommended for the S and B fuel block. When the ratio of the number of carbon to heavy metal atoms changes with the geometric parameters of the fuel block in the range of 200–250, the reactivity swing reaches very small values. Furthermore, for a reactivity swing of 0.1 Δk during 10 effective full power years, three configurations with 36, 54 and 78 UO{sub 2} fuel rods are recommended for the application of the U-Battery. The comparison analysis of the S and B fuel block with the Th/U MOX fuel block shows that the former has a longer lifetime and a lower reactivity swing.

Operating experiences with heat-exchanging components of a semi-technical pilot plant for steam gasification of coal using heat from HTR

International Nuclear Information System (INIS)

Kirchhoff, R.; Heek, K.H. van

1984-01-01

within the framework of the PNP- Project, a semi-technical plant for the development of a process of coal gasification by means of nuclear heat was operated. Here gasification is for the first time implemented in a fluidized bed using heat of an electrically heated helium cycle at pressure up to 40 bar and temperatures normal for HTR. The plant serves for testing and developing various components as immersion heater, insulations, dosing devices, and for compiling sound data for further planning

Immunoglobulins from sera of APS patients bind HTR-8/SVneo trophoblast cell line and reduce additional mediators of cell invasion.

Science.gov (United States)

Jovanović Krivokuća, Milica; Abu Rabi, Tamara; Stefanoska, Ivana; Vrzić-Petronijević, Svetlana; Petronijević, Miloš; Vićovac, Ljiljana

2017-12-01

Immunoglobulins from sera of patients with antiphospholipid syndrome (APS) decrease trophoblast cell invasion in vitro. This study aimed to extend understanding of cellular effects of immunoglobulins from APS (aPL+) in HTR-8/SVneo cells. aPL+ IgG induced change in effector molecules important for cell invasion was investigated further. After 1h of culture 21% cells bound aPL+ IgG, as opposed to 6% in control (aPL-). This was accompanied by increase in phospho-p38 at 30min. After 24h treatment aPL+IgG decreased protein levels of integrin subunits α1 (78% of control; p<0.01), α4 (65% of control, p<0.01), α5 (76% of control; p<0.01) and β1 (80% of control; p<0.01), and secreted gal-1 (68% of control; p<0.05). ProMMP-9 was reduced to 70% of control (p<0.001). Treatment with inhibitor of p38 MAPK signaling SB202190 reversed inhibition in integrin β1 and secreted gal-1. Involvement of p38 MAPK signaling and decrease in integrin subunit α4 , proMMP-9, and secreted gal-1 in HTR-8/SVneo cells are novel and extend the list of mediators of trophoblast invasion affected by aPL. Copyright © 2017 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

Beam-plasma interaction in a cold-cathodes penning discharge; Interaction faisceau-plasma dans une decharge penning a cathodes froides

Energy Technology Data Exchange (ETDEWEB)

Bliman, S L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1966-06-01

The H.F. emissions from a cold-cathode reflex discharge are studied. An experimental law for the frequency variation shows that f{alpha}V{sup 1/2} discharged if B{sub 0} and p are constant. If B{sub 0} is made to increase, the frequencies change such that f{sub ce} - f emitted / f{sub ce} decreases. With each emitted frequency there is associated a stationary wave system making it possible to measure the phase velocity V{phi} of the waves. This phase velocity is always close to that of the fast electrons accelerated by a potential V discharge. A non-quasistatic formalism for the propagation of waves in a beam-plasma system is then established. The Maxwell equations are solved taking into account boundary conditions. Comparison of these experiments with the theory shows a satisfactory agreement. (author) [French] On etudie les emissions H.F. d'une decharge reflex a cathodes froides. Une loi experimentale de variation des frequences montre que f{alpha}V{sup 1/2} decharge, si B{sub 0} et p sont fixes. Si on fait croitre B{sub 0}, les frequences evoluent de sorte que f{sub ce} - f emise / f{sub ce} diminue. A chaque frequence emise est associe un systeme d'ondes stationnaires qui permet la mesure de la vitesse de phase V{phi} des ondes. Cette vitesse de phase est toujours voisine de celle des electrons rapides acceleres sous la tension V decharge. On etablit ensuite un formalisme non quasistatique de propagation d'ondes dans un systeme faisceau plasma. On resoud les equations de MAXWELL avec conditions aux limites. La comparaison des experiences a la theorie aboutit a un accord satisfaisant. (auteur)

Beam-plasma interaction in a cold-cathodes penning discharge; Interaction faisceau-plasma dans une decharge penning a cathodes froides

Energy Technology Data Exchange (ETDEWEB)

Bliman, S.L. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1966-06-01

The H.F. emissions from a cold-cathode reflex discharge are studied. An experimental law for the frequency variation shows that f{alpha}V{sup 1/2} discharged if B{sub 0} and p are constant. If B{sub 0} is made to increase, the frequencies change such that f{sub ce} - f emitted / f{sub ce} decreases. With each emitted frequency there is associated a stationary wave system making it possible to measure the phase velocity V{phi} of the waves. This phase velocity is always close to that of the fast electrons accelerated by a potential V discharge. A non-quasistatic formalism for the propagation of waves in a beam-plasma system is then established. The Maxwell equations are solved taking into account boundary conditions. Comparison of these experiments with the theory shows a satisfactory agreement. (author) [French] On etudie les emissions H.F. d'une decharge reflex a cathodes froides. Une loi experimentale de variation des frequences montre que f{alpha}V{sup 1/2} decharge, si B{sub 0} et p sont fixes. Si on fait croitre B{sub 0}, les frequences evoluent de sorte que f{sub ce} - f emise / f{sub ce} diminue. A chaque frequence emise est associe un systeme d'ondes stationnaires qui permet la mesure de la vitesse de phase V{phi} des ondes. Cette vitesse de phase est toujours voisine de celle des electrons rapides acceleres sous la tension V decharge. On etablit ensuite un formalisme non quasistatique de propagation d'ondes dans un systeme faisceau plasma. On resoud les equations de MAXWELL avec conditions aux limites. La comparaison des experiences a la theorie aboutit a un accord satisfaisant. (auteur)

Verify Super Double-Heterogeneous Spherical Lattice Model for Equilibrium Fuel Cycle Analysis AND HTR Spherical Super Lattice Model for Equilibrium Fuel Cycle Analysis

International Nuclear Information System (INIS)

Gray S. Chang

2005-01-01

The currently being developed advanced High Temperature gas-cooled Reactors (HTR) is able to achieve a simplification of safety through reliance on innovative features and passive systems. One of the innovative features in these HTRs is reliance on ceramic-coated fuel particles to retain the fission products even under extreme accident conditions. Traditionally, the effect of the random fuel kernel distribution in the fuel pebble/block is addressed through the use of the Dancoff correction factor in the resonance treatment. However, the Dancoff correction factor is a function of burnup and fuel kernel packing factor, which requires that the Dancoff correction factor be updated during Equilibrium Fuel Cycle (EqFC) analysis. An advanced KbK-sph model and whole pebble super lattice model (PSLM), which can address and update the burnup dependent Dancoff effect during the EqFC analysis. The pebble homogeneous lattice model (HLM) is verified by the burnup characteristics with the double-heterogeneous KbK-sph lattice model results. This study summarizes and compares the KbK-sph lattice model and HLM burnup analyzed results. Finally, we discuss the Monte-Carlo coupling with a fuel depletion and buildup code--ORIGEN-2 as a fuel burnup analysis tool and its PSLM calculated results for the HTR EqFC burnup analysis

HTR fuel modelling with the ATLAS code. Thermal mechanical behaviour and fission product release assessment

International Nuclear Information System (INIS)

Guillermier, Pierre; Daniel, Lucile; Gauthier, Laurent

2009-01-01

To support AREVA NP in its design on HTR reactor and its HTR fuel R and D program, the Commissariat a l'Energie Atomique developed the ATLAS code (Advanced Thermal mechanicaL Analysis Software) with the objectives: - to quantify, with a statistical approach, the failed particle fraction and fission product release of a HTR fuel core under normal and accidental conditions (compact or pebble design). - to simulate irradiation tests or benchmark in order to compare measurements or others code results with ATLAS evaluation. These two objectives aim at qualifying the code in order to predict fuel behaviour and to design fuel according to core performance and safety requirements. A statistical calculation uses numerous deterministic calculations. The finite element method is used for these deterministic calculations, in order to be able to choose among three types of meshes, depending on what must be simulated: - One-dimensional calculation of one single particle, for intact particles or particles with fully debonded layers. - Two-dimensional calculations of one single particle, in the case of particles which are cracked, partially debonded or shaped in various ways. - Three-dimensional calculations of a whole compact slice, in order to simulate the interactions between the particles, the thermal gradient and the transport of fission products up to the coolant. - Some calculations of a whole pebble, using homogenization methods are being studied. The temperatures, displacements, stresses, strains and fission product concentrations are calculated on each mesh of the model. Statistical calculations are done using these results, taking into account ceramic failure mode, but also fabrication tolerances and material property uncertainties, variations of the loads (fluence, temperature, burn-up) and core data parameters. The statistical method used in ATLAS is the importance sampling. The model of migration of long-lived fission products in the coated particle and more

Analysis of Random-Loading HTR-PROTEUS Cores with Continuous Energy Monte Carlo Code Based on A Statistical Geometry Model

International Nuclear Information System (INIS)

Murata, Isao; Miyamaru, Hiroyuki

2008-01-01

Spherical elements have remarkable features in various applications in the nuclear engineering field. In 1990's, by the project of HTR-PROTEUS at PSI various pebble bed reactor experiments were conducted including cores with a lot of spherical fuel elements loaded randomly. In this study, criticality experiments of the random-loading HTR-PROTEUS cores were analyzed by MCNP-BALL, which could deal with a random arrangement of spherical fuel elements exactly with a statistical geometry model. As a result of analysis, the calculated effective multiplication factors were in fairly good agreement with the measurements within about 0.5%Δk/k. In comparison with other numerical analysis, our effective multiplication factors were between the experimental values and the VSOP calculations. To investigate the discrepancy of the effective multiplication factors between the experiments and calculations, sensitivity analyses were performed. As the result, the sensitivity of impurity boron concentration was fairly large. The reason of the present slight overestimation was not made clear at present. However, the presently existing difference was thought to be related to the impurity boron concentration, not to the modelling of the reactor and the used nuclear data. From the present study, it was confirmed that MCNP-BALL would have an advantage to conventional transport codes by comparing with their numerical results and the experimental values. As for the criticality experiment of PROTEUS, we would conclude that the two cores of Core 4.2 and 4.3 could be regarded as an equivalent experiment of a reference critical core, which was packed in the packing fraction of RLP. (authors)

Analysis of Random-Loading HTR-PROTEUS Cores with Continuous Energy Monte Carlo Code Based on A Statistical Geometry Model

Energy Technology Data Exchange (ETDEWEB)

Murata, Isao; Miyamaru, Hiroyuki [Division of Electrical, Electronic and Information Engineering, Osaka University, Yamada-oka 2-1, Suita, Osaka, 565-0871 (Japan)

2008-07-01

Spherical elements have remarkable features in various applications in the nuclear engineering field. In 1990's, by the project of HTR-PROTEUS at PSI various pebble bed reactor experiments were conducted including cores with a lot of spherical fuel elements loaded randomly. In this study, criticality experiments of the random-loading HTR-PROTEUS cores were analyzed by MCNP-BALL, which could deal with a random arrangement of spherical fuel elements exactly with a statistical geometry model. As a result of analysis, the calculated effective multiplication factors were in fairly good agreement with the measurements within about 0.5%DELTAk/k. In comparison with other numerical analysis, our effective multiplication factors were between the experimental values and the VSOP calculations. To investigate the discrepancy of the effective multiplication factors between the experiments and calculations, sensitivity analyses were performed. As the result, the sensitivity of impurity boron concentration was fairly large. The reason of the present slight overestimation was not made clear at present. However, the presently existing difference was thought to be related to the impurity boron concentration, not to the modelling of the reactor and the used nuclear data. From the present study, it was confirmed that MCNP-BALL would have an advantage to conventional transport codes by comparing with their numerical results and the experimental values. As for the criticality experiment of PROTEUS, we would conclude that the two cores of Core 4.2 and 4.3 could be regarded as an equivalent experiment of a reference critical core, which was packed in the packing fraction of RLP. (authors)

Critical evaluation of the experiments and mathematical models for the determination of fission product release from the spherical fuel elements in cases of core heating accidents in modular HTR's

International Nuclear Information System (INIS)

Bailly, H.W.

1987-01-01

In this work, the thermal behaviour of modular reactors in cases of core heating accidents and the physical phenomena relevant for a release of radioactive materials from HTR fuel elements are explained as far as is necessary for understanding the work. The present mathematical models by which the release of radioactive materials from HTR fuel elements due to diffusion or breaking particles in cases of core heating accidents are also described, examined and evaluated with regard to their applicability to module reactors. The experiments used to verify the mathematical models are also evaluated. The mathematical models are in nearly all cases computer programs, which describe the complicated process of releasing radioactive materials quantitative mathematically. One should point out that these models are constantly being developed further, in line with the increasing amount of knowledge. To conclude the work, proposals are made for improving the certainty of information from experiments and mathematical models to determine the release behaviour of modular reactors. (orig./GL) [de

Evaluation of the Control Rod Super Alloy Material of HTR-PM

International Nuclear Information System (INIS)

Li Pengjun; Yan He; Diao Xingzhong

2014-01-01

The control rod drive mechanism (CRDM) system is served as the first reactivity control and shutdown system for the high temperature reactor pebble-bed module (HTR-PM) in Shandong, China. And the control rod, which is pulled up and down by a chain sprocket mechanism of CRDM to realize reactivity control, compensation and shutdown, has to be durable under temperature as high as 550℃ for a long time. Thus the material persistent strength under high temperature is quite important for the reliability of the CRDM. In this paper, a review on material selection of control rod of high temperature gas cooled reactors, including AVR and THTR-300 in Germany, HTTR in Japan, PBMR in South Africa and Dragon in Britain, was summarized. The major parameters of two kinds of high temperature alloy, incoloy 800H and alloy 625, were compared and discussed. According to the ASME NH volume, a design criterion for the control rod was established and applied in the analysis of the chain by using finite element method. The numerical simulations showed that the chain made of alloy 625 could meet the condition and work for a long time under high temperature. (author)

Fission product release profiles from spherical HTR fuel elements at accident temperatures

International Nuclear Information System (INIS)

Schenk, W.; Pitzer, D.; Nabielek, H.

1986-10-01

A total of 22 fuel elements with modern TRISO particles has been tested in the temperature range 1500-2500 0 C. Additionally, release profiles of iodine and other isotopes have been obtained with seven UO 2 samples at 1400-1800 0 C. For heating times up to 100 hours at the maximum temperature, the following results are pertinent to HTR accident conditions: Ag 110 m is the only fission products to be released at 1200-1600 0 C by diffusion through intact SiC, but it is of low significance in accident assessments; cesium, iodine, strontium, and noble gas releases up to 1600 0 C are solely due to various forms of contamination; at 1700-1800 0 C, corrosion induced SiC defects cause the release of Cs, Sr, I/Xe/Kr; above 2000 0 C, thermal decomposition of the silicon carbide layer sets in while pyrocarbons still remain intact. Around 1600 0 C, the accident specific contribution of cesium, strontium, iodine, and noble gases is negligible. (orig./HP) [de

Recruitment by the Repressor Freud-1 of Histone Deacetylase-Brg1 Chromatin Remodeling Complexes to Strengthen HTR1A Gene Repression.

Science.gov (United States)

Souslova, Tatiana; Mirédin, Kim; Millar, Anne M; Albert, Paul R

2017-12-01

Five-prime repressor element under dual repression binding protein-1 (Freud-1)/CC2D1A is genetically linked to intellectual disability and implicated in neuronal development. Freud-1 represses the serotonin-1A (5-HT1A) receptor gene HTR1A by histone deacetylase (HDAC)-dependent or HDAC-independent mechanisms in 5-HT1A-negative (e.g., HEK-293) or 5-HT1A-expressing cells (SK-N-SH), respectively. To identify the underlying mechanisms, Freud-1-associated proteins were affinity-purified from HEK-293 nuclear extracts and members of the Brg1/SMARCCA chromatin remodeling and Sin3A-HDAC corepressor complexes were identified. Pull-down assays using recombinant proteins showed that Freud-1 interacts directly with the Brg1 carboxyl-terminal domain; interaction with Brg1 required the carboxyl-terminal of Freud-1. Freud-1 complexes in HEK-293 and SK-N-SH cells differed, with low levels of BAF170/SMARCC2 and BAF57/SMARCE1 in HEK-293 cells and low-undetectable BAF155/SMARCC1, Sin3A, and HDAC1/2 in SK-N-SH cells. Similarly, by quantitative chromatin immunoprecipitation, Brg1-BAF170/57 and Sin3A-HDAC complexes were observed at the HTR1A promoter in HEK-293 cells, whereas in SK-N-SH cells, Sin3A-HDAC proteins were not detected. Quantifying 5-HT1A receptor mRNA levels in cells treated with siRNA to Freud-1, Brg1, or both RNAs addressed the functional role of the Freud-1-Brg1 complex. In HEK-293 cells, 5-HT1A receptor mRNA levels were increased only when both Freud-1 and Brg1 were depleted, but in SK-N-SH cells, depletion of either protein upregulated 5-HT1A receptor RNA. Thus, recruitment by Freud-1 of Brg1, BAF155, and Sin3A-HDAC complexes appears to strengthen repression of the HTR1A gene to prevent its expression inappropriate cell types, while recruitment of the Brg1-BAF170/57 complex is permissive to 5-HT1A receptor expression. Alterations in Freud-1-Brg1 interactions in mutants associated with intellectual disability could impair gene repression leading to altered neuronal

Influence of the interaction between environmental quality and T102C SNP in the HTR2A gene on fibromyalgia susceptibility.

Science.gov (United States)

Mergener, Michelle; Becker, Roze Mary Ribas; dos Santos, Adriana Freitag; dos Santos, Geraldine Alves; de Andrade, Fabiana Michelsen

2011-12-01

This study aimed to investigate the genetic influence of the T102C polymorphism of the 2A serotonin receptor gene (HTR2A) and its interaction with environmental aspects, such as exposure to noise, traffic, climate, and opportunities to acquire new information, physical protection, and security, among others, as possible risk factors for developing fibromyalgia syndrome (FMS). Forty-one FMS patients and 49 controls were evaluated. Environmental factors were evaluated by application of the V domain of the WHOQOL-100 questionnaire. Patients were asked that their answers represented only the periods preceding the onset of symptoms. The T102C variant of the HTR2A gene was determined through PCR/RFLP. Among patients, the frequency of carriers of the 102C allele was higher than in controls (76.5% vs. 50%; P = 0.028). The scores of the V domain were lower in patients than in controls, indicating a worst perception of the environmental quality by patients (P quality of social care and health" together with the presence of the 102C allele also increased this chance by more than 90-fold (P = 0.005). However, carriers of the same allele who have high quality social care and health are not at a higher risk to develop FMS. These data suggest that these factors may predispose to FMS, especially in carriers of the 102C allele. However, studies with larger samples are required to confirm this hypothesis.

ARCHER HTR Technology in support of a Coal to Liquid Process – An Economic Feasibility View

International Nuclear Information System (INIS)

Stoker, P.W.; Fick, J.I.J.; Conradie, F.H.

2014-01-01

The paper considers the economics of coupling a European developed HTR (as conceptualized by project ARCHER) to a Coal-to-Liquid (CTL) process as typically used by Sasol, the biggest Coal-to-Liquid (CTL) producer in the world. The approach followed was to create a techno-economic baseline for an existing CTL process using mass and energy balances determined with Aspen Plus chemical modelling software. The economic performance of a typical 80,000 barrels per day synthetic crude oil plant was determined from first principles. The techno-economic baseline model was validated with reference to published product output data and audited financial results of a Sasol CTL plant located at Secunda, South Africa, as reported for the 2011 financial year. A number of schemes were identified to couple the European HTR plant to the CTL case study. Two schemes were studied in detail, while the remaining coupling schemes will be studied as part of the follow-on project NC2I-R (Nuclear Cogeneration Industrial Initiative – Research). Two Key Performance Indices were of interest, namely the Internal Rate of Return of a Nuclear supported CTL plant and the reduction of CO_2 emissions. The case where nuclear co-generation replaced electrical power bought from the grid, and also replaced all the steam currently produced by the burning coal with nuclear steam, yielded interesting conclusions: • The case study plant would need a total of 16 HTRs, each with a capacity of 265 MWth. • The coupling scheme would reduce CO_2 emissions by approximately 14.5 million ton/annum or 51 % of the current emissions of a 80,000 bbl/d plant. • The economic feasibility challenge for large scale deployment of nuclear energy in a Coal-to-Liquid application - where steam and electricity are to be generated from Nuclear energy, is to construct such a facility at an all -inclusive overnight cost not exceeding $3400/kWe. (author)

Fission product behaviour in the primary circuit of an HTR

International Nuclear Information System (INIS)

Decken, C.B. von der; Iniotakis, N.

1981-01-01

The knowledge of fission product behaviour in the primary circuit of a High Temperature Reactor (HTR) is an essential requirement for the estimations of the availability of the reactor plant in normal operation, of the hazards to personnel during inspection and repair and of the potential danger to the environment from severe accidents. On the basis of the theoretical and experimental results obtained at the ''Institute for Reactor Components'' of the KFA Juelich /1/,/2/ the transport- and deposition behaviour of the fission- and activation products in the primary circuit of the PNP-500 reference plant has been investigated thoroughly. Special work had been done to quantify the uncertainties of the investigations and to calculate or estimate the dose rate level at different components of the primary cooling circuit. The contamination and the dose rate level in the inspection gap in the reactor pressure vessel is discussed in detail. For these investigations in particular the surface structure and the composition of the material, the chemical state of the fission products in the cooling gas, the composition of the cooling gas and the influence of dust on the transport- and deposition behaviour of the fission products have been taken into account. The investigations have been limited to the nuclides Ag-110m; Cs-134 and Cs-137

The behaviour of spherical HTR fuel elements under accident conditions

Energy Technology Data Exchange (ETDEWEB)

Schenk, W; Naoumidis, A [Institute for Reactor Material, KFA Juelich (Germany)

1985-07-01

Hypothetical accidents may lead to significantly higher temperatures in HTR fuel than during normal operation. In order to obtain meaningful statements on fission product behaviour and release, irradiated spherical fuel elements containing a large number of coated particles (20,000-40,000) with burnups between 6 and 16% FIMA were heated at temperatures between 1400 and 2500 deg. C. HTI-pyrocarbon coating retains the gaseous fission products (e.g. Kr) very well up to about 2400 deg. C if the burnup does not exceed the specified value for THTR (11.5%). Cs diffuses through the pyrocarbon significantly faster than Kr and the diffusion is enhanced at higher fuel burnups because of irradiation induced kernel microstructure changes. Below about 1800 deg. C the Cs release rate is controlled by diffusion in the fuel kernel; above this temperature the diffusion in the pyrocarbon coating is the controlling parameter. An additional SiC coating interlayer (TRISO) ensures Cs retention up to 1600 deg. C. However, the release obtained in the examined fuel elements was only by a factor of three lower than through the HTI pyrocarbon. Solid fission products added to UO{sub 2}-TRISO particles to simulate high burnup behave in various ways and migrate to attack the SiC coating. Pd migrates fastest and changes the SiC microstructure making it permeable.

Thorium utilization in a small long-life HTR. Part I: Th/U MOX fuel blocks

Energy Technology Data Exchange (ETDEWEB)

Ding, Ming, E-mail: dingm2005@gmail.com [Delft University of Technology, Reactor Institute Delft, Mekelweg 15, 2629 JB, Delft (Netherlands); Harbin Engineering University, Nantong Street 145, 150001 Harbin (China); Kloosterman, Jan Leen, E-mail: j.l.kloosterman@tudelft.nl [Delft University of Technology, Reactor Institute Delft, Mekelweg 15, 2629 JB, Delft (Netherlands)

2014-02-15

Highlights: • We propose thorium MOX (TMOX) fuel blocks for a small block-type HTR. • The TMOX fuel blocks with low-enriched uranium are recommended. • More thorium decreases the reactivity swing of the TMOX fuel blocks. • Thorium reduces the negative temperature coefficient of the TMOX fuel blocks. • Thorium increases the conversion ratio of the TMOX fuel blocks. - Abstract: The U-Battery is a small, long-life and transportable high temperature gas-cooled reactor (HTR). The neutronic features of a typical fuel block with uranium and thorium have been investigated for a application of the U-Battery, by parametrically analyzing the composition and geometric parameters. The type of fuel block is defined as Th/U MOX fuel block because uranium and thorium are assumed to be mixed in each fuel kernel as a form of (Th,U)O{sub 2}. If the initially loaded mass of U-235 is mostly consumed in the early period of the lifetime of Th/U MOX fuel block, low-enriched uranium (LEU) as ignited fuel will not largely reduce the neutronic performance of the Th/U MOX fuel block, compared with high-enriched uranium. The radii of fuel kernels and fuel compacts and packing fraction of TRISO particles determine the atomic ratio of the carbon to heavy metal. When the ratio is smaller than 400, the difference among them due to double heterogeneous effects can be neglected for the Th/U MOX fuel block. In the range between 200 and 400, the reactivity swing of the Th/U MOX fuel block during 10 years is sufficiently small. The magnitude of the negative reactivity temperature coefficients of the Th/U MOX fuel block decreases by 20–45%, which is positive to reduce temperature defect of the Th/U MOX fuel block. The conversion ratio (CR) of the fuel increases from 0.48 (typical CR of the LEU-fueled U-Battery) to 0.78. The larger conversion ratio of the Th/U MOX fuel block reduces the reactivity swing during 10 years for the U-Battery.

Transient behaviour of small HTR for cogeneration

International Nuclear Information System (INIS)

Verkerk, E.C.; Van Heek, A.I.

2000-01-01

The Dutch market for combined generation of heat and power identifies a unit size of 40 MW thermal for the conceptual design of a nuclear cogeneration plant. The ACACIA system provides 14 MWe electricity combined with 17 t/h of high temperature steam (220 deg C, 10 bar) with a pebble-bed high temperature reactor directly coupled with a helium compressor and a helium turbine. The design of this small CHP unit that is used for industrial applications is mainly based on a pre-feasibility study in 1996, performed by a joint working group of five Dutch organisations, in which technical feasibility was shown. Thermal hydraulic and reactor physics analyses show favourable control characteristics during normal operation and a benign response to loss of helium coolant and loss of flow conditions. Throughout the response on these highly infrequent conditions, ample margin exists between the highest fuel temperatures and the temperature above which fuel degradation will occur. To come to quantitative statements about the ACACIA transient behaviour, a calculational coupling between the high temperature reactor core analysis code package PANTHER/DIREKT and the thermal hydraulic code RELAP5 for the energy conversion system has been made. This coupling offers a more realistic simulation of the entire system, since it removes the necessity of forcing boundary conditions on the simulation models at the data transfer points. In this paper, the models used for the dynamic components of the energy conversion system are described, and the results of the calculation for two operational transients in order to demonstrate the effects of the interaction between reactor core and its energy conversion system are shown. Several transient cases that are representative as operational transients for an HTR will be discussed, including one representing a load rejection case that shows the functioning of the control system, in particular the bypass valve. Another transient is a load following

The HTR-10 test reactor project and potential use of HTGR for non-electric application in China

International Nuclear Information System (INIS)

Sun Yuliang; Zhong Daxin; Xu Yuanhui; Wu Zhongxin

1997-01-01

Coal is the dominant source of energy in China. This use of coal results in two significant problems for China; it is a major burden on the train, road and waterway transportation infrastructures and it is a significant source of environmental pollution. In order to ease the problems caused by the burning of coal and to help reduce the energy supply shortage in China, national policy has directed the development of nuclear power. This includes the erection of nuclear power plants with water cooled reactors and the development of advanced nuclear reactor types, specifically, the high temperature gas cooled reactor (HTGR). The HTGR was chosen for its favorable safety features and its ability to provide high reactor outlet coolant temperatures for efficient power generation and high quality process heat for industrial applications. As the initial modular HTGR development activity within the Chinese High Technology Programme, a 10MW helium cooled test reactor is currently under construction on the site of the Institute of Nuclear Energy Technology northwest of Beijing. This plant features a pebble-bed helium cooled reactor with initial criticality anticipated in 1999. There will be two phases of high temperature heat utilization from the HTR-10. The first phase will utilize a reactor outlet temperature of 700 deg. C with a steam generator providing steam for a steam turbine cycle which works on an electrical/heat co-generation basis. The second phase is planned for a core outlet temperature of 900 deg. C to investigate a steam cycle/gas turbine combined cycle system with the gas turbine and the steam cycle being independently parallel in the secondary side of the plant. This paper provides a review of the technical design, licensing, safety and construction schedule for the HTR-10. It also addresses the potential uses of the HTGR for non-electric applications in China including process steam for the petrochemical industry, heavy oil recovery, coal conversion and

A technique to simulate a tube break in a high-pressure gas/cooling water heat exchanger - HTR2008-58161

International Nuclear Information System (INIS)

Antwerpen, H. J. V.; Mulder, E. J.

2008-01-01

The gas cycles of most High Temperature Gas-Cooled Reactors (HTR's) reject heat to water at some stage. In the helium/water heat exchangers of HTR's with direct Brayton cycles, the helium is usually at a much higher pressure than the water. If the pressure boundary between the helium and the water fails inside the heat exchanger. the effect on the rest of the water system has to be established in order to do a proper system design. This can be done most efficiently by using a system simulation code, however, very few system simulation codes has the capability to do gas/liquid interface tracking as required for this problem. This study describes a calculation method with which a gas/liquid heat exchanger tube rupture can be calculated in a simulation code without interface tracking. The course of events after tube rupture is described and appropriate calculation models derived. A mathematical model for a pressure relief valve (PRV) was also created. The calculation models were implemented in the system simulation software Flownex and used to study a tube rupture on a 5000 kPa helium/water heat exchanger. The assembled calculation network solved stable and within reasonable time. The simulation provided insight into the course of events following the tube break. It was shown that the acceleration of water out of the helium cooler, by choked-flow helium, caused the main pressure pulses during the event. The maximum pressure in the water loop occurs on the opposite side of the helium cooler due to constructive interference of the initial pressure wave with itself. It was also shown that by changing only pipe lengths, the system could become prone to severe oscillations after a tube rupture event. (authors)

Metallic materials for heat exchanger components and highly stressed internal of HTR reactors for nuclear process heat generation

International Nuclear Information System (INIS)

1982-01-01

The programme was aimed at the development and improvement of materials for the high-temperature heat exchanger components of a process steam HTR. The materials must have high resistance to corrosion, i.e. carburisation and internal oxidation, and high long-term toughness over a wide range of temperatures. They must also meet the requirements set in the nuclear licensing procedure, i.e. resistance to cyclic stress and irradiation, non-destructive testing, etc. Initially, it was only intended to improve and qualify commercial alloys. Later on an alloy development programme was initiated in which new, non-commercial alloys were produced and modified for use in a nuclear process heat facility. Separate abstracts were prepared for 19 pays of this volume. (orig./IHOE) [de

Thermohydraulic simulation of HTR-10 nuclear reactor core using realistic CFD approach; Simulacao termohidraulica do nucleo do reator nuclear HTR-10 com o uso da abordagem realistica CFD

Energy Technology Data Exchange (ETDEWEB)

Silva, Alexandro S.; Dominguez, Dany S., E-mail: alexandrossilva@gmail.com, E-mail: dsdominguez@gmail.com [Universidade Estadual de Santa Cruz (UESC), Ilheus, BA (Brazil); Mazaira, Leorlen Y. Rojas; Hernandez, Carlos R.G., E-mail: leored1984@gmail.com, E-mail: cgh@instec.cu [Instituto Superior de Tecnologias y Ciencias Aplicadas, La Habana (Cuba); Lira, Carlos Alberto Brayner de Oliveira, E-mail: cabol@ufpe.br [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil)

2015-07-01

High-temperature gas-cooled reactors (HTGRs) have the potential to be used as possible energy generation sources in the near future, owing to their inherently safe performance by using a large amount of graphite, low power density design, and high conversion efficiency. However, safety is the most important issue for its commercialization in nuclear energy industry. It is very important for safety design and operation of an HTGR to investigate its thermal–hydraulic characteristics. In this article, it was performed the thermal–hydraulic simulation of compressible flow inside the core of the pebble bed reactor HTR (High Temperature Reactor)-10 using Computational Fluid Dynamics (CFD). The realistic approach was used, where every closely packed pebble is realistically modelled considering a graphite layer and sphere of fuel. Due to the high computational cost is impossible simulate the full core; therefore, the geometry used is a column of FCC (Face Centered Cubic) cells, with 41 layers and 82 pebbles. The input data used were taken from the thermohydraulic IAEA Benchmark (TECDOC-1694). The results show the profiles of velocity and temperature of the coolant in the core, and the temperature distribution inside the pebbles. The maximum temperatures in the pebbles do not exceed the allowable limit for this type of nuclear fuel. (author)

High temperature crevice corrosion of heat-resistant Ni-base alloy in the simulated HTR helium

International Nuclear Information System (INIS)

Kiuchi, Kiyoshi; Kondo, Tatsuo

1980-03-01

Interaction between a Ni-base heat-resistant alloy and the simulated HTR primary coolant environment was examined with emphasis on the reactions inside narrow crevice gaps. A new method using Mo crevice cells was developed to obtain reproducible quantitative results. The test environment was characterized by the low oxidizing species as trace gaseous impurities. Series of sequential phenomena were observed: i.e. the preferential consumptions of oxidizing species in the outer part of the crevice, followed by the lack of oxide film and the resultant extensive carburization further inside the crevice. A model on the possible phenomena occurring at tips of the cracks formed during creep or fatigue tests and low flow rate portions in the reactor primary circuit as well. The feasibility of the interpretation was checked referring to the existing numerical formula and using the experimental results obtained parameters. Calculations reproduced penetration curves of the Cr- oxidation with reasonable accuracy. (author)

The use and development of the high-temperature reactor (HTR) in China. A conference report

International Nuclear Information System (INIS)

Marnet, C.

2001-01-01

Gas-cooled graphite-moderated reactors have been under development since the early days of nuclear technology. Starting with plants in Britain and France, reactors employing this combination of coolant and moderator were used in commercial nuclear power plants in the second half of the fifties. At the same time, efforts seeking to use inert helium gas as a coolant resulted in the construction in several countries, the United States and Germany in particular, of larger nuclear power plants with higher coolant temperatures and the resultant thermodynamic advantages of high efficiencies and the option of process heat generation. Economic and political considerations led to the decommissioning of these plants. Today, research and development of high-temperature reactors are concentrated on smaller units. Work is carried out in close international cooperation, especially on project designs and newly commissioned plants in China (HTR-10), Japan (HTTR, Oarai), And South Africa (ESKOM project), but also in the USA and in Russia. (orig.) [de

The application of HTR type modular plants in refinieries and for aluminium oxide production

International Nuclear Information System (INIS)

Schad, M.; Clausen, E.; Funke, A.; Heng, R.; Poesche, W.; Simon, P.; Schwarz, T.; Feltes, W.; Hague, H.; Heidkamp, H.; Hesse, K.; Kohtz, N.; Mendte, K.; Ullrich, M.; Wild, W.; Zipper, E.

1991-02-01

The aim of the second study of coupling the HTR module to process plants consistsed in developing concepts for potential plants and analysing them again for their technical and economic feasibility. At each of the three process plants, heat is coupled in by a He/He intermediate heat exchanger. This principle of heat coupling was consistently aimed at - in order to keep the expensive nuclear part of plant coupling as small as possible, and - in order to avoid that primary helium can get into the process plants, just as vice versa process media into the HTRM-helium circuit. For refineries this principle is easy to comply with because of the low process temperatures of below 600deg C. For aluminium oxide production which conventionally requires a temperature of about 950deg C, calcination tests were made at lower process temperatures, and parallely the feed-in of heat to reach the highest process temperature through electric heating was studied. For petrochemistry, heat transfer during naptha cracking was closely analysed. (orig./GL) [de

HTR-PROTEUS benchmark calculations. Pt. 1. Unit cell results LEUPRO-1 and LEUPRO-2

International Nuclear Information System (INIS)

Hogenbirk, A.; Stad, R.C.L. van der; Janssen, A.J.; Klippel, H.T.; Kuijper, J.C.

1995-09-01

In the framework of the IAEA Co-ordinated Research Programme (CRP) on 'Validation of Safety Related Physics Calculations for Low-Enriched (LEU) HTGRs' calculational benchmarks are performed on the basis of LEU-HTR pebble-bed critical experiments carried out in the PROTEUS facility at PSI, Switzerland. Of special interest is the treatment of the double heterogeneity of the fuel and the spherical fuel elements of these pebble bed core configurations. Also of interest is the proper calculation of the safety related physics parameters like the effect of water ingress and control rod worth. This document describes the ECN results of the LEUPRO-1 and LEUPRO-2 unitcell calculations performed with the codes WIMS-E, SCALE-4 and MCNP4A. Results of the LEUPRO-1 unit cell with 20% water ingress in the void is also reported for both the single and the double heterogeneous case. Emphasis is put on the intercomparison of the results obtained by the deterministic codes WIMS-E and SCALE-4, and the Monte Carlo code MCNP4A. The LEUPRO whole core calculations will be reported later. (orig.)

Modelling of HTR Confinement Behaviour during Accidents Involving Breach of the Helium Pressure Boundary

Directory of Open Access Journals (Sweden)

Joan Fontanet

2009-01-01

Full Text Available Development of HTRs requires the performance of a thorough safety study, which includes accident analyses. Confinement building performance is a key element of the system since the behaviour of aerosol and attached fission products within the building is of an utmost relevance in terms of the potential source term to the environment. This paper explores the available simulation capabilities (ASTEC and CONTAIN codes and illustrates the performance of a postulated HTR vented confinement under prototypical accident conditions by a scoping study based on two accident sequences characterized by Helium Pressure Boundary breaches, a small and a large break. The results obtained indicate that both codes predict very similar thermal-hydraulic responses of the confinement both in magnitude and timing. As for the aerosol behaviour, both codes predict that most of the inventory coming into the confinement is eventually depleted on the walls and only about 1% of the aerosol dust is released to the environment. The crosscomparison of codes states that largest differences are in the intercompartmental flows and the in-compartment gas composition.

Thermohydraulic simulation of HTR-10 nuclear reactor core using realistic CFD approach

International Nuclear Information System (INIS)

Silva, Alexandro S.; Dominguez, Dany S.; Mazaira, Leorlen Y. Rojas; Hernandez, Carlos R.G.; Lira, Carlos Alberto Brayner de Oliveira

2015-01-01

High-temperature gas-cooled reactors (HTGRs) have the potential to be used as possible energy generation sources in the near future, owing to their inherently safe performance by using a large amount of graphite, low power density design, and high conversion efficiency. However, safety is the most important issue for its commercialization in nuclear energy industry. It is very important for safety design and operation of an HTGR to investigate its thermal–hydraulic characteristics. In this article, it was performed the thermal–hydraulic simulation of compressible flow inside the core of the pebble bed reactor HTR (High Temperature Reactor)-10 using Computational Fluid Dynamics (CFD). The realistic approach was used, where every closely packed pebble is realistically modelled considering a graphite layer and sphere of fuel. Due to the high computational cost is impossible simulate the full core; therefore, the geometry used is a column of FCC (Face Centered Cubic) cells, with 41 layers and 82 pebbles. The input data used were taken from the thermohydraulic IAEA Benchmark (TECDOC-1694). The results show the profiles of velocity and temperature of the coolant in the core, and the temperature distribution inside the pebbles. The maximum temperatures in the pebbles do not exceed the allowable limit for this type of nuclear fuel. (author)

Nuclear graphite wear properties and estimation of graphite dust production in HTR-10

Energy Technology Data Exchange (ETDEWEB)

Luo, Xiaowei, E-mail: xwluo@tsinghua.edu.cn; Wang, Xiaoxin; Shi, Li; Yu, Xiaoyu; Yu, Suyuan

2017-04-15

Highlights: • Graphite dust. • The wear properties of graphite. • Pebble bed. • High Temperature Gas-cooled Reactor. • Fuel element. - Abstract: The issue of the graphite dust has been a research focus for the safety of High Temperature Gas-cooled Reactors (HTGRs), especially for the pebble bed reactors. Most of the graphite dust is produced from the wear of fuel elements during cycling of fuel elements. However, due to the complexity of the motion of the fuel elements in the pebble bed, there is no systematic method developed to predict the amount the graphite dust in a pebble bed reactor. In this paper, the study of the flow of the fuel elements in the pebble bed was carried out. Both theoretical calculation and numerical analysis by Discrete Element Method (DEM) software PFC3D were conducted to obtain the normal forces and sliding distances of the fuel elements in pebble bed. The wearing theory was then integrated with PFC3D to estimate the amount of the graphite dust in a pebble bed reactor, 10 MW High Temperature gas-cooled test Reactor (HTR-10).

Advancements in reactor physics modelling methodology of Monte Carlo Burnup Code MCB dedicated to higher simulation fidelity of HTR cores

International Nuclear Information System (INIS)

Cetnar, Jerzy

2014-01-01

The recent development of MCB - Monte Carlo Continuous Energy Burn-up code is directed towards advanced description of modern reactors, including double heterogeneity structures that exist in HTR-s. In this, we exploit the advantages of MCB methodology in integrated approach, where physics, neutronics, burnup, reprocessing, non-stationary process modeling (control rod operation) and refined spatial modeling are carried in a single flow. This approach allows for implementations of advanced statistical options like analysis of error propagation, perturbation in time domain, sensitivity and source convergence analyses. It includes statistical analysis of burnup process, emitted particle collection, thermal-hydraulic coupling, automatic power profile calculations, advanced procedures of burnup step normalization and enhanced post processing capabilities. (author)

Establishment of quality control technology for HTR fuel in Korea

International Nuclear Information System (INIS)

Lee, Young-Woo; Kim, Woong Ki; Kim, Yeon Ku; Cho, Moon Sung

2009-01-01

Korea is currently developing the HTR coated particle fuel technology in view of its long-term Nuclear Hydrogen Production Technology Development and Demonstration (NHDD) Project, which was launched in 2004, of an extensive R and D program on technology development for a hydrogen production by a VHTR. The current NHDD Project essentially covers the R and D works on the core and reactor system analysis, thermo-hydraulics and safety, coated particle fuel technology, material and component aspects and the hydrogen production technology by using the so-called Sulfur-Iodine Process (S-I Process). As a part of the NHDD Project, the fundamental technology for the coated particle fuel has been being developed, which consist of UO 2 kernel fabrication, pyrolytic carbon (PyC) and silicon carbide (SiC) coating technology, an in-reactor performance model development of a coated particle fuel and a preliminary preparative study for the irradiation tests of the coated particle fuel specimens in the HANARO reactor. In parallel with the development of fabrication process technology of the coated particle fuel, namely, kernel fabrication and coating processes, the characterization techniques for the important characteristics and quality control (QC) methods of the products after each process step were established. This paper deals with the works carried out for the development of the characterization technologies and establishment of the QC techniques for the coated fuel particles. Emphasis is given to the selection and development of the laboratory equipment and apparatus for the development of the methods of the characterizations and relevant QC methods

Evidencia de asociación entre el gen SLC6A4 y efectos epistáticos con variantes en HTR2A en la etiología del autismo en la población antioqueña

Directory of Open Access Journals (Sweden)

Ana Victoria Valencia

2012-12-01

Full Text Available Introducción. El espectro autista constituye un grupo de trastornos graves del neurodesarrollo, conun fuerte componente genético. Se ha sugerido un papel importante del sistema serotoninérgico en el desarrollo de este grupo de trastornos, con base en los estudios de respuesta a medicamentos y la hiperserotoninemia, característica común en el autismo. Se han implicado múltiples moléculas en el metabolismo y la neurotransmisión de la serotonina; sin embargo, los resultados de los estudios hantenido poca congruencia entre diferentes poblaciones. Objetivos. Evaluar la relación entre el autismo y el polimorfismo de nucleótido simple (SingleNucleotide Polymorphism, SNP en los genes SLC6A4, HTR2A e ITGB3, en una muestra de la población antioqueña. Materiales y métodos. Se genotipificaron 42 núcleos familiares con autismo para 10 variantes enlos genes SLC6A4, ITGB3 y HTR2A. Se evaluó la asociación utilizando la prueba de desequilibrio enla transmisión. Se exploró el impacto de la interacción entre estos genes y el autismo, utilizando la reducción multidimensional. Resultados. Se encontró asociación de las variantes rs4583306 (OR=2,6, p=0,004 y rs2066713(OR=2,2 p=0,03, en el gen SLC6A4, y asociación de combinaciones genotípicas entre los genes SLC6A4 y HTR2A y el riesgo de autismo (p=0,0001. Conclusiones. Se encontró asociación significativa con variantes en el gen transportador de serotoninacon el autismo, al igual que interacción entre variantes en los genes HTR2A con SLC6A4. Estos resultados concuerdan con los de estudios previos en otras poblaciones y son pruebas a favor delpapel del sistema serotoninérgico en la etiología del espectro autista.   doi: http://dx.doi.org/10.7705/biomedica.v32i4.593

Initial Start-Up and Testing of the Fort St. Vrain HTGR – Lessons Learned which May Be Useful for the HTR-PM

International Nuclear Information System (INIS)

Brey, H.L.

2014-01-01

Although the activities presented in this paper occurred 40 years ago, there are many observations and lessons associated with Fort St. Vrain (FSV) which may be beneficial in support of the start-up, testing and licensing of the HTR-PM. This report includes a review of the FSV NPP design including an overview of the requirements and testing program utilized to bring the plant from initial start-up to full power. A sampling of the test results as well as a comparison of the plant design characteristics to actual values achieved at 100% power along with selected overall experiences gained through operation of this plant is also included. (author)

Access rules for imports and exports on the French public power transmission network; Regles d'acces au reseau public de transport francais pour des importations et des exportations

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-10-01

These rules define the technical, financial and legal conditions applied to imports and/or exports made by the user on the French public power transmission grid (Reseau Public de Transport - RPT), considering the available capacity on interconnections and any particular technical constraints of the European interconnected network, notably in terms of safety: 1 - definitions; 2 - general conditions (scope, participation conditions, user obligations, signature, enforcement and duration of the participation agreement, attachment of transactions to a balance responsible entity, rules modification procedure, access to the information system, financial conditions, guarantee of exchange programmes, transfer of rights and obligations, intellectual property, confidentiality, force majeure, responsibility, termination, notifications and operational exchange procedures, territorial application of the rules, applicable law and language, dispute resolution); 3 - conditions for the application of imports and exports (allocating transmission capacity on interconnections, allocating import capacity, changing a capacity allocation mechanism, the different categories of exchange programmes, standard programmes, weekly programmes, daily programmes, nominations in the event of a failure in the information system, information published by RTE); 4 - conditions for the application of intra-day transactions (intra-day transaction requests, processing intra-day transaction requests, modification of an intra-day transactions programme). 16 models of correspondence documents are given in appendixes.

Effect of the hydro-thermal load history on the high-temperature creep of HTR-concrete

International Nuclear Information System (INIS)

Diederichs, U.; Rostasy, F.S.; Becker, G.

1991-01-01

In the research and development works for the prestressed concrete vessel for the HTR-500 high temperature reactor, the comprehensive tests concerning mix design, manufacture as well as mechanical and thermal behavior of the concrete have been carried out. The concrete was put to the numerous tests for determining the strength and the creep behavior at elevated temperature. In the real PCRV, the concrete is heated at different heating rate depending on the location of a certain volume element of the concrete in the structure. Furthermore, the heat transport simultaneously causes the moisture transport. For this reason, the test has been planned to investigate the transient creep at various heating rates and in different states of moisture during heating to the accident temperature up to 300 deg C. The cylindrical specimens were used for the high temperature creep test. The test procedure and the test results are reported. It was shown that the thermal history (heating rate, duration of holding at a certain temperature and so on) determines the transient creep deformation to a great extent. (K.I.)

A phenomenon of direct conversion of ionizing energy resulting from the formation of negative droplets by electron capture during condensation of a vapour even without electronic affinity; Sur un phenomene de conversion directe d'energie ionisante resultant de la formation de gouttelettes negatives par capture d'electrons, lors de la condensation d'une vapeur, meme sans affinite electronique

Energy Technology Data Exchange (ETDEWEB)

Kraux, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1969-06-01

An electromotive force is produced between a cold and a hot electrode immersed in an ionized vapour. It is shown that the dissymmetry thus created consists in the formation of heavy, negative charge carriers following the condensation of the vapour in the volume close to the cold electrode. The electromotive forces produced are explained on the basis of a decrease in the floating potential of the cold electrode. (author) [French] Une force electromotrice apparaissant entre une electrode chaude et une electrode froide plongees dans une vapeur ionisee, on etablit que la disymetrie ainsi causee consiste en la formation de porteurs de charge negatifs lourds consecutive a la condensation de la vapeur en volume pres de l'electrode froide. On justifie les forces electromotrices observees par la diminution du potentiel flottant de l'electrode froide. (auteur)

Fundamental principles for a nuclear design and structural analysis code for HTR components operating at temperatures above 8000C

International Nuclear Information System (INIS)

Nickel, H.; Schubert, F.

1985-01-01

With reference to the special characteristics of an HTR plant for the supply of nuclear process heat, the investigation of the fundamental principles to form the basis for a high temperature nuclear structural design code has been described. As examples, preliminary design values are proposed for the creep rupture and fatigue behaviour. The linear damage accumulation rule is for practical reasons proposed for the determination of service life, and the difficulties in using this rule are discussed. Finally, using the data obtained in structural analysis, the main areas of investigation which will lead to improvements in the utilization of the materials are discussed. Based on the current information, the working group ''Design Code'' believes that a service life of 70000 h for the heat-exchanging components operating at above 800 0 C can be. (orig.)

A real-time data acquisition and processing system for the analytical laboratory automation of a HTR spent fuel reprocessing facility

International Nuclear Information System (INIS)

Watzlawik, K.H.

1979-12-01

A real-time data acquisition and processing system for the analytical laboratory of an experimental HTR spent fuel reprocessing facility is presented. The on-line open-loop system combines in-line and off-line analytical measurement procedures including data acquisition and evaluation as well as analytical laboratory organisation under the control of a computer-supported laboratory automation system. In-line measurements are performed for density, volume and temperature in process tanks and registration of samples for off-line measurements. Off-line computer-coupled experiments are potentiometric titration, gas chromatography and X-ray fluorescence analysis. Organisational sections like sample registration, magazining, distribution and identification, multiple data assignment and especially calibrations of analytical devices are performed by the data processing system. (orig.) [de

Effects of homogeneous geometry models in simulating the fuel balls in HTR-10

International Nuclear Information System (INIS)

Wang Mengjen; Liang Jenqhorng; Peir Jinnjer; Chao Dersheng

2012-01-01

In this study, the core geometry of HTR-10 was simulated using four different models including: (1) model 1 - an explicit double heterogeneous geometry, (2) model 2 - a mixing of UO 2 kernel and four layers in each TRISO particle into one, (3) model 3 - a mixing of 8,335 TRISO particles and the inner graphite matrix in each fuel ball into one, and (4) model 4 - a mixing of the outer graphite shell, 8,335 TRISO particles, and the inner graphite matrix in each fuel ball into one. The associated initial core computations were performed using the MCNP version 1.51 computer code. The experimental fuel loading height of 123 cm was employed for each model. The results revealed that the multiplication factors ranged from largest to smallest with model 1, model 2, model 3, and model 4. The neutron spectrum in the fuel region of each models varied from the hardest to the softest are model 1, model 2, model 3, and model 4 while the averaged neutron spectrum in fuel ball from hardest to softest are model 4, model 3, model 2, and model 1. In addition, the CPU execution times extended from longest to shortest with model 1, model 2, model 3, and model 4. (author)

Performance assessment of auxiliary bearing in HTR-10 AMB helium circulator on the event of rotor drop

International Nuclear Information System (INIS)

Xiao Zhen; Yang Guojun; Li Yue; Shi Zhengang; Yu Suyuan

2014-01-01

In this paper, a model for analyzing internal contact stress arid external load of ball bearing from rotor displacement was developed based on the Hertz contact theory and applied to the analysis of the rotor drop test in HTR-10 helium circulator equipped with AMB (Active Magnetic Bearing) to gain a better understanding of auxiliary bearing performance at different stages after the rotor drop. It was shown that the auxiliary bearing can well resist axial impact produced by rotor drop, avoiding of internal severe plastic deformation and damage to the performance of the auxiliary bearing. Rotor's rotary motion and the heat accumulation of the inner ring resulted from the initial acute acceleration are the main contributor of radial load during the rotor idling and may cause the failure of auxiliary bearing. This paper analyzed the influence of this load and confirmed that the auxiliary bearing can still work in its loading limits. (authors)

Initial Startup and Testing of the Fort St. Vrain HTGR - Lessons Learned which May Be Useful to the HTR-PM

International Nuclear Information System (INIS)

Brey, Larry H.

2014-01-01

Lessons Learned: Although the HTR-PM and FSV incorporate significant differences in their designs, there are lessons to be learned that are applicable to both plants. This is especially important for key systems that incorporate first-of-a-kind equipment. Basically, these lessons are just an application of common sense. • Complexity Breeds Unavailability. Incorporate system/components that are ruggedly simple in design with a history of reliable operation and minimal maintenance. • Assure Strong Expertise and Funding for this First HTR-PM. Quite likely, the successful startup and operation of this plant will require a level of support considerably greater than a typical nuclear plant. • Be Very Attentive to the Design Aspects of first-of-a-kind Components in the Class 1, Safety-Related Portions of the Plant. For example; a generic metallurgical failure could easily lead to a very long plant shutdown in order to redesign the failed component, re-license, manufacture, install and test prior to plant resuming plant operation. • Where Possible, Test all Key Systems/Components Prior to Installation using Actual Plant Configuration & Operating Characteristics This will help assure operational capability prior to application of nuclear heat. • Never Attempt to Start an Innovative Nuclear Power Plant Without First Having the Proper Regulatory Guides and Criteria in Place. FSV was licensed as a Research Facility. There was no Standard Review Plan or Regulatory Guides in place for the NRC (or PSC) to utilize in regulating this HTGR. • Do Not Be Reluctant to Incorporate a Generous Over-Build Capability into Systems/Components. It is significantly easier to design extra margin into the original compressors, pumps and motors than to be required to backfit into larger units after plant start-up. • Assure All Safety Documents Reflect the Actual Capability of the Plant to Respond to Accidents Described in the Safety Analysis. FSV was limited to 82% power during the

Means, methods and performances of the AREVA's HTR compact controls

International Nuclear Information System (INIS)

Banchet, J.; Guillermier, P.; Tisseur, D.; Vitali, M. P.

2008-01-01

In the AREVA's HTR development program, the reactor plant is composed of a prismatic core containing graphite cylindrical fuel elements, called compacts, where TRISO particles are dispersed. Starting from its past compacting process, the latter being revamped through the use of state of the art equipments, CERCA, 100% AREVA NP's subsidiary, was able to recover the quality of past compacts production. The recovered compacting process is composed of the following manufacturing steps: graphite matrix granulation, mix between the obtained granulates and particles, compacting and calcining at low pressure and temperature. To adapt this past process to new manufacturing equipments, non destructive examination tests were carried out to assess the compact quality, the latter being assessed via in house developed equipments and methods at each step of the design of experiments. As for the manufacturing process, past quality control methods were revamped to measure compact dimensional features (diameter, perpendicularity and cone effect), visual aspect, SiC layer failure fraction (via anodic disintegration and burn leach test) and homogeneity via 2D radiography coupled to ceramography. Although meeting quality requirements, 2D radiography method could not provide a quantified specification for compact homogeneity characterization. This limitation yielded the replacement of this past technique by a method based on X-Ray tomography. Development was conducted on this new technique to enable the definition of a criterion to quantify compact homogeneity, as well as to provide information about the distances in between particles. This study also included a comparison between simulated and real compacts to evaluate the accuracy of the technique as well as the influence of particle packing fraction on compact homogeneity. The developed quality control methods and equipments guided the choices of manufacturing parameters adjustments at the development stage and are now applied for

Numerical Study on the Helium Flow Characteristics for Steam Generator Subsystem of HTR

International Nuclear Information System (INIS)

Ha, Jung Hoon; Ham, Jin Ki; Ki, Min-Hwan; Lee, Won Jae

2014-01-01

The High Temperature Reactor (HTR), one of the 4th generation reactors, utilizes helium as the primary coolant. A Steam Generator Subsystem (SGS) is installed to transfer heat from the primary coolant to feed water and subsequently produce steam so that it supplies electricity as well as process heat over a wide range. The SGS is composed of a helical heat exchanger, shrouds directing the flow of the shell side helium and support systems, which are located within the steam generator vessel. In this study, helium flow characteristics in the SGS were investigated at various operating conditions using Computational Fluid Dynamics (CFD). A full-scale 3-D model of the SGS was developed and the reynolds stress model with standard wall treatment was used as a turbulence model. The CFD result was compared to that of the concept design of the steam cycle modular helium reactor for the design verification of the SGS. From the CFD analysis, it was found that the primary coolant flow had non-uniform distribution while it passed the inlet in the helical heat exchanger. In order to make the uniform primary coolant flow uniform, a special type of screen was suggested in front of the helical heat exchanger. As a result, the overall design adequacy of the SGS has been evaluated. (author)

The second Euratom sponsored 9000C HTR fuel irradiation experiment in the HFR Petten Project E 96.02: Pt.2. Post-irradiation examination

International Nuclear Information System (INIS)

Roettger, R.; Bueger, J. de; Schoots, T.

1977-01-01

A large variety of HTR fuel specimens, loose coated particles, coupons and compacts provided by Belgonucleaire, the Dragon Project and the KFA Juelich have been irradiated in the HFR at Petten at about 900 0 C up to a maximum fast neutron fluence of about 7x10 21 cm -2 (EDN) as a Euratom sponsored experiment. The maximum burn-ups were between 11 and 18.5% FIMA. The results of the post-irradiation examinations, comprising visual inspection, dimensional measurements, microradiography, metallography, and burn-up determinations are presented in this part 2 of the final report. The examinations have shown that the endurance limit of most of the tested fuel varieties is beyond the reached irradiation values

Modulation of FABP4 hypomethylation by DNMT1 and its inverse interaction with miR-148a/152 in the placenta of preeclamptic rats and HTR-8 cells.

Science.gov (United States)

Yang, Anning; Zhang, Huiping; Sun, Yue; Wang, Yanhua; Yang, Xiaoming; Yang, Xiaoling; Zhang, Hui; Guo, Wei; Zhu, Guangrong; Tian, Jue; Jia, Yuexia; Jiang, Yideng

2016-10-01

Inflammation and dysregulated lipid metabolism are involved in the pathogenesis of preeclampsia, and fatty acid binding protein 4 (FABP4) is known to regulate both inflammation and lipid metabolism. In the present study, we elucidated the role of FABP4 using in vitro and in vivo models of preclampsia. We found increased expression of FABP4 in the placenta of preeclamptic rats, which was further confirmed in HTR-8 cells, an extravillous trophoblast cell line, treated with L-NAME. Overexpression of FABP4 in HTR-8 cells resulted in upregulated expression of pro-inflammatory cytokines IL-6 and TNF-α, and increased lipid accumulation, suggesting that FABP4 plays a role in preeclampsia. Furthermore, downregulation of methylation in the promotor resulted in increased FABP4 expression, which was mediated by downregulated DNA methyltransferase 1 (DNMT1). Bioinformatics analysis showed that miR-148a/152 regulated the expression of DNMT1, and additional in vitro studies revealed that miR-148a/152 inhibited DNMT1 expression by directly binding to its 3'-UTR. Interestingly, DNMT1 enhanced the expression of miR-148a/152 by downregulation of methylation in its promotor. Taken together, our results showed that FABP4 may be involved in the pathogenesis of preeclampsia, and the expression of FABP4 is enhanced by miR-148a/152 mediated inhibition of DNMT1 expression. Copyright © 2016 Elsevier Ltd. All rights reserved.

Nouvelles: KEK: B pour BELLE; NA48 mesure la violation directe de CP; LEL: le laser à électrons libres dépasse le kilowatt; Le LEP à 100 pour 100; Tour d'honneur au RHIC; Mesures de précision; Etude sur les modes de gestion du village planétaire; Conférence PANIC99 à Uppsala; Rencontre électron-noyau à HERA; LPP, Doubna célèbre une décennie; Les physiciens auscultent le photon; Aimants chauds venus du froid

CERN Multimedia

1999-01-01

Nouvelles: KEK: B pour BELLE; NA48 mesure la violation directe de CP; LEL: le laser à électrons libres dépasse le kilowatt; Le LEP à 100 pour 100; Tour d'honneur au RHIC; Mesures de précision; Etude sur les modes de gestion du village planétaire; Conférence PANIC99 à Uppsala; Rencontre électron-noyau à HERA; LPP, Doubna célèbre une décennie; Les physiciens auscultent le photon; Aimants chauds venus du froid

The Nature of the Phonon Spectrum and the Analysis of Lattice Thermal Conductivity; Nature du Spectre des Phonons et Analyse de la Conductibilite Thermique du Reseau; Kharakter fononnogo spektra i analiz teploprovodnosti reshetki; Naturaleza del Espectro Fononico y Analisis de la Conductividad Termica Reticular

Energy Technology Data Exchange (ETDEWEB)

Joshi, S. K.; Sharma, K. C. [Physics Department, Allahabad University, Allahabad (India)

1965-04-15

auteurs presentent les resultats d'une etude sur la conductibilite thermique des reseaux effectuee au moyen d'un spectre de phonons plus precis que le spectre de phonons analogue au modele de Debye, utilise d'ordinaire, qui est constitue par une seule branche acoustique moyenne. Pour calculer les variations en fonction de la temperature de la conductibilite thermique du reseau du germanium, ils ont utilise tout d'abord un modele anisotrope de dispersion en continu et suivi comme methode une version modifiee de la formulation de Callaway. Pour effectuer la sommation d'integrales complexes sur les frequences du reseau, ils ont applique la methode d'integration a six et trois termes de Houston. On utilise les expressions appropriees des temps de relaxation pour les diffusions a la frontiere et les diffusions dues aux impuretes ainsi que pour le processus normal a trois phonons et le processus Umklapp. Pour le germanium entre 2 et 1000 Degree-Sign K, on obtient une concordance satisfaisante avec les donnees experimentales de Holland et de Slack et Glassbrenner en ajustant les quatre constantes presentes dans les integrales. D'apres des donnees de spectroscopie des neutrons dignes de foi, on sait que le germanium comporte des branches transversales tres dispersees et qu'un modele anisotrope de dispersion en continu en donne aussi une mauvaise representation. Les auteurs ont donc juge bon d'utiliser le modele des couches tres complexes pour la dynamique de reseau du germanium presente pai Cochran. En ajustant les parametres entrant dans la formulation qu'ils ont utilisee pour le calcul de la conductibilite thermique du reseau, ils ont egalement obtenu des resultats concordant avec les donnees experimentales. Ceci leur a donne a penser que la nature du spectre des phonons n'a pas une grande influence sur l'analyse des donnees relatives a la conductibilite thermique du reseau suivant les methodes actuelles, et que le spectre des phonons perd de sa precision en raison de l

Subsystem Testing and Flight Test Instrumentation.

Science.gov (United States)

1981-04-01

du isoteur avec loa autres systemes do Ilavion. L’anticipation et la r~solution do con probl~mom doivent absolument Atro r~alis~es do faqon...carburant avian. Des esosis, par temps chaud et froid , sont g~n~ralement inclus dens tout programme de d6veloppemont (Kiruna (Finlande) ot Marrakech...trim froide , ainsi quaosur des terrains on altitude pormottont ensuite de contr8ler la vaLidit6 den conaignee do d~marrage propos6es. 7 -ALINENTATION

Advanced Technology for Aero Gas Turbine Components: Conference Proceedings Held at the Propulsion and Energetics Panel (69th) Symposium in Paris (France) on 4-8 May 1987

Science.gov (United States)

1987-09-01

Simuitaniment, Ia forte composante tangentielle de l’coulement absolu en sortie du mobile doit Otre annulbe, ce qui corres pond A une diviation de...calculs quasi-tridimensionnpls. Le essais a froid de la turbine sur le banc et len ensais correnpondants A chaud sur le turbomoteur permettent d...0.5Re 0 e 6 .10 6 (A froid ) Rapport de la vitesse p~riph~rique sur la vitesse de jet U er/V.j = 0.69 3 - PREDIMENSIONNEMENT DE LA TURBINE RADIALE

Temperature modeling for analysis and design of the sintering furnance in HTR fuel type of ball

International Nuclear Information System (INIS)

Saragi, Elfrida; Setiadji, Moch

2013-01-01

One of the factors that determine the safety of the operation of the sintering furnace fuel HTR ball is the temperature distribution in the ceramic tube furnace. The temperature distribution must be determined at design stage. The tube has a temperature of 1600 °C at one end and about 40 °C at the other end. The outside of the tube was cooled by air through natural convection. The tube is a furnace ceramic tube which its geometry are 0.08, 0.09 and 0.5 m correspondingly for the inner tube diameter, outer tube diameter and tube length. The temperature distribution of the tube is determined by the natural convection coefficient (NCF), which is difficult to be calculated manually. The determination of NCF includes the Grasshoff, Prandtl, and Nusselt numbers which is a function of the temperature difference between the surrounding air with the ceramic tube. If the temperature vary along the tube, the complexity of the calculations increases. Thus the proposed modeling was performed to determine the temperature distribution along the tube and heat transfer coefficient using a self-developed software which permit the design process easier

Recent advances on thermohydraulic simulation of HTR-10 nuclear reactor core using realistic CFD approach

Energy Technology Data Exchange (ETDEWEB)

Silva, Alexandro S., E-mail: alexandrossilva@ifba.edu.br [Instituto Federal de Educacao, Ciencia e Tecnologia da Bahia (IFBA), Vitoria da Conquista, BA (Brazil); Mazaira, Leorlen Y.R., E-mail: leored1984@gmail.com, E-mail: cgh@instec.cu [Instituto Superior de Tecnologias y Ciencias Aplicadas (INSTEC), La Habana (Cuba); Dominguez, Dany S.; Hernandez, Carlos R.G., E-mail: alexandrossilva@gmail.com, E-mail: dsdominguez@gmail.com [Universidade Estadual de Santa Cruz (UESC), Ilheus, BA (Brazil). Programa de Pos-Graduacao em Modelagem Computacional; Lira, Carlos A.B.O., E-mail: cabol@ufpe.br [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil)

2015-07-01

High-temperature gas-cooled reactors (HTGRs) have the potential to be used as possible energy generation sources in the near future, owing to their inherently safe performance by using a large amount of graphite, low power density design, and high conversion efficiency. However, safety is the most important issue for its commercialization in nuclear energy industry. It is very important for safety design and operation of an HTGR to investigate its thermal-hydraulic characteristics. In this article, it was performed the thermal-hydraulic simulation of compressible flow inside the core of the pebble bed reactor HTR (High Temperature Reactor)-10 using Computational Fluid Dynamics (CFD). The realistic approach was used, where every closely packed pebble is realistically modelled considering a graphite layer and sphere of fuel. Due to the high computational cost is impossible simulate the full core; therefore, the geometry used is a FCC (Face Centered Cubic) cell with the half height of the core, with 21 layers and 95 pebbles. The input data used were taken from the thermal-hydraulic IAEA Bechmark. The results show the profiles of velocity and temperature of the coolant in the core, and the temperature distribution inside the pebbles. The maximum temperatures in the pebbles do not exceed the allowable limit for this type of nuclear fuel. (author)

Recent advances on thermohydraulic simulation of HTR-10 nuclear reactor core using realistic CFD approach

International Nuclear Information System (INIS)

Silva, Alexandro S.; Mazaira, Leorlen Y.R.; Dominguez, Dany S.; Hernandez, Carlos R.G.

2015-01-01

High-temperature gas-cooled reactors (HTGRs) have the potential to be used as possible energy generation sources in the near future, owing to their inherently safe performance by using a large amount of graphite, low power density design, and high conversion efficiency. However, safety is the most important issue for its commercialization in nuclear energy industry. It is very important for safety design and operation of an HTGR to investigate its thermal-hydraulic characteristics. In this article, it was performed the thermal-hydraulic simulation of compressible flow inside the core of the pebble bed reactor HTR (High Temperature Reactor)-10 using Computational Fluid Dynamics (CFD). The realistic approach was used, where every closely packed pebble is realistically modelled considering a graphite layer and sphere of fuel. Due to the high computational cost is impossible simulate the full core; therefore, the geometry used is a FCC (Face Centered Cubic) cell with the half height of the core, with 21 layers and 95 pebbles. The input data used were taken from the thermal-hydraulic IAEA Bechmark. The results show the profiles of velocity and temperature of the coolant in the core, and the temperature distribution inside the pebbles. The maximum temperatures in the pebbles do not exceed the allowable limit for this type of nuclear fuel. (author)

Enhancing the Sustainability of Nuclear Power: the Pebble Bed HTR in Deep Burn Mode

International Nuclear Information System (INIS)

Da Cruz, D.F.; De Haas, J.B.M.; Van Heek, A.I.

2004-01-01

The scenario of a utility in an industrialized country starting new nuclear construction with a single PBMR reactor has been considered. To make the new construction project acceptable by government and society, a maximum effort to obtain sustainability (i.e. minimization of resource use and waste production) will have to be shown. Therefore the usual open cycle for HTR has been abandoned, and the spent fuel will be reprocessed once. The long-lived transuranic (TRU) elements Pu, Np, Am and Cm are all re-fabricated into so-called transmutation fuel elements, and loaded back into the same reactor, in our case a 110 MWe PBMR with low-enriched uranium cycle. In this study, the reactor physical prospects have been investigated: to what extent the amount of TRU could be reduced. In this way, 75% of the initial amount of TRU waste is being destructed, while the time span in which the waste is more radio-toxic than uranium ore is being reduced to one-third. Also, the amount of fresh driver fuel needed is decreases by 25%. A preliminary cost analysis has been performed as well. It shows that there is also a cost advantage of operating the reactor in Deep Burn mode in industrialized countries, where the waste storage fees charged per volume are relatively high. (authors)

Airframe/Propulsion Interference

Science.gov (United States)

1975-03-01

point de recollement. abscisse. temperature absolue . trainee de culot. vltesse. X t abscisse. 6-2 X t distance inter-tuyeres. OC i angle...secondaire assurant deux roles principaux i tout d’abord guldage et melange du flux froid de ventilation et du jet chaud, ensuite adaptation des...l’ambiante et une valeur de V eL’:alo a 1,4 (air froid ). ’ On notera que les calculs effectuEs par la mEthode d’elements finis (v 2) ont eto

Minimum Nuclear Deterrence Research

Science.gov (United States)

2003-05-15

ressources nationales et qui, manié avec autant de sang- froid que de détermination, devrait, par la dissuasion, lui permettre d’échapper à certaines grandes...in providing credibility to the deterrent. 47 See Bruno Tertrais, "La Dissuasion Nucléaire Française Après La Guerre Froide : Continuité, Ruptures...ces situations de stabilité plus ou moins absolue ." The translations are the SAIC author’s. Beaufre, Dissuasion et Stratégie, op.cit.; this text

Survival at Sea for Mariners, Aviators and Search and Rescue Personnel (Survie en mer pour les marins, les aviateurs et le personnel de recherche et de sauvetage)

Science.gov (United States)

2008-02-01

of Figures viii List of Tables ix Preface x Technical Course HFM-152 xi Executive Summary and Synthèse ES-1 Chapter 1 – Introduction to the RTO...Survival at Sea for Mariners, Aviators and Search and Rescue Personnel (RTO-AG-HFM-152) Executive Summary This NATO RTO Technical Course on Marine...Lors d’accidents en eau froide, il est fort probable que le choc thermique dû au froid ainsi que l’épuisement à la nage entraînent davantage la

HTR-PROTEUS Pebble Bed Experimental Program Cores 1, 1A, 2, and 3: Hexagonal Close Packing with a 1:2 Moderator-to-Fuel Pebble Ratio

Energy Technology Data Exchange (ETDEWEB)

John D. Bess; Barbara H. Dolphin; James W. Sterbentz; Luka Snoj; Igor Lengar; Oliver Köberl

2013-03-01

In its deployment as a pebble bed reactor (PBR) critical facility from 1992 to 1996, the PROTEUS facility was designated as HTR-PROTEUS. This experimental program was performed as part of an International Atomic Energy Agency (IAEA) Coordinated Research Project (CRP) on the Validation of Safety Related Physics Calculations for Low Enriched HTGRs. Within this project, critical experiments were conducted for graphite moderated LEU systems to determine core reactivity, flux and power profiles, reaction-rate ratios, the worth of control rods, both in-core and reflector based, the worth of burnable poisons, kinetic parameters, and the effects of moisture ingress on these parameters. Four benchmark experiments were evaluated in this report: Cores 1, 1A, 2, and 3. These core configurations represent the hexagonal close packing (HCP) configurations of the HTR-PROTEUS experiment with a moderator-to-fuel pebble ratio of 1:2. Core 1 represents the only configuration utilizing ZEBRA control rods. Cores 1A, 2, and 3 use withdrawable, hollow, stainless steel control rods. Cores 1 and 1A are similar except for the use of different control rods; Core 1A also has one less layer of pebbles (21 layers instead of 22). Core 2 retains the first 16 layers of pebbles from Cores 1 and 1A and has 16 layers of moderator pebbles stacked above the fueled layers. Core 3 retains the first 17 layers of pebbles but has polyethylene rods inserted between pebbles to simulate water ingress. The additional partial pebble layer (layer 18) for Core 3 was not included as it was used for core operations and not the reported critical configuration. Cores 1, 1A, 2, and 3 were determined to be acceptable benchmark experiments.

Risk and protective genetic variants in suicidal behaviour: association with SLC1A2, SLC1A3, 5-HTR1B &NTRK2 polymorphisms.

LENUS (Irish Health Repository)

Murphy, Therese M

2012-02-01

BACKGROUND: Suicidal behaviour is known to aggregate in families. Patients with psychiatric disorders are at higher risk for suicide attempts (SA), however protective and risk genetic variants for suicide appear to be independent of underlying psychiatric disorders. Here we investigate genetic variants in genes important for neurobiological pathways linked to suicidal behaviour and\\/or associated endophenotypes, for association with SA among patients with co-existing psychiatric illness. Selected gene-gene and gene-environment interactions were also tested. METHODS: DNA was obtained from bloods of 159 patients (76 suicide attempters and 83 non-attempters), who were profiled for DSM-IV Axis I psychiatric diagnosis. Twenty-eight single nucleotide polymorphisms (SNPs) from 18 candidate genes (COMT, 5-HT2A, 5-HT1A, 5-HTR1B, TPH1, MAO-A, TPH2, DBH, CNR1, BDNF, ABCG1, GABRA5, GABRG2, GABRB2, SLC1A2, SLC1A3, NTRK2, CRHR1) were genotyped. Genotyping was performed by KBioscience. Tests of association between genetic variants and SA were conducted using Chi squared and Armitage Trend tests. Binary logistical regression analyses were performed to evaluate the contribution of individual genetic variants to the prediction of SA, and to examine SNPs for potential gene-gene and gene-environment interactions. RESULTS: Our analysis identified 4 SNPs (rs4755404, rs2269272, rs6296 and rs1659400), which showed evidence of association with SA compared to a non-attempter control group. We provide evidence of a 3-locus gene-gene interaction, and a putative gene-environment interaction, whereby genetic variation at the NTRK2 locus may moderate the risk associated with history of childhood abuse. CONCLUSION: Preliminary findings suggest that allelic variability in SLC1A2\\/3, 5-HTR1B and NTRK2 may be relevant to the underlying diathesis for suicidal acts.

HTR-PROTEUS Pebble Bed Experimental Program Cores 1, 1A, 2, and 3: Hexagonal Close Packing with a 1:2 Moderator-to-Fuel Pebble Ratio

Energy Technology Data Exchange (ETDEWEB)

John D. Bess; Barbara H. Dolphin; James W. Sterbentz; Luka Snoj; Igor Lengar; Oliver Köberl

2012-03-01

In its deployment as a pebble bed reactor (PBR) critical facility from 1992 to 1996, the PROTEUS facility was designated as HTR-PROTEUS. This experimental program was performed as part of an International Atomic Energy Agency (IAEA) Coordinated Research Project (CRP) on the Validation of Safety Related Physics Calculations for Low Enriched HTGRs. Within this project, critical experiments were conducted for graphite moderated LEU systems to determine core reactivity, flux and power profiles, reaction-rate ratios, the worth of control rods, both in-core and reflector based, the worth of burnable poisons, kinetic parameters, and the effects of moisture ingress on these parameters. Four benchmark experiments were evaluated in this report: Cores 1, 1A, 2, and 3. These core configurations represent the hexagonal close packing (HCP) configurations of the HTR-PROTEUS experiment with a moderator-to-fuel pebble ratio of 1:2. Core 1 represents the only configuration utilizing ZEBRA control rods. Cores 1A, 2, and 3 use withdrawable, hollow, stainless steel control rods. Cores 1 and 1A are similar except for the use of different control rods; Core 1A also has one less layer of pebbles (21 layers instead of 22). Core 2 retains the first 16 layers of pebbles from Cores 1 and 1A and has 16 layers of moderator pebbles stacked above the fueled layers. Core 3 retains the first 17 layers of pebbles but has polyethylene rods inserted between pebbles to simulate water ingress. The additional partial pebble layer (layer 18) for Core 3 was not included as it was used for core operations and not the reported critical configuration. Cores 1, 1A, 2, and 3 were determined to be acceptable benchmark experiments.

Variation of the material laplacian of G1 with the radius of the uranium bar; Variation du laplacien matiere de G1 avec le rayon du barreau d'uranium

Energy Technology Data Exchange (ETDEWEB)

Tanguy, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1957-07-01

In this report are described and interpreted some experiments, carried out in the pile G1 during a period of shut-down, which have made it possible to measure the variation of the material Laplacian of the lattice with the radius of the uranium bar. The variation of the reactivity of the pile is measured when an increasing number of fuel elements are progressively replaced in the central region by fuel elements of greater diameter; it is shown that, starting from measurements based on less than ten per cent of the total number of elements, the variation of reactivity corresponding to the replacement of all the elements can be determined; it is then easy to deduce the variations of the Laplacian. Results: the variations of the Laplacian with the uranium rod diameter are 0 (d. 26 mm), +0.065 {+-} 0.004 m{sup -2} (d. 28 mm) and +0.080 {+-} 0.008 m{sup -2} (d. 32 mm). (author) [French] Dans ce rapport sont decrites et interpretees des experiences realisees sur la pile G1 'froide', experiences qui ont permis de mesurer la variation du Laplacien matiere du reseau avec le rayon du barreau d'uranium. On mesure la variation de reactivite de la pile lorsqu'on remplace progressivement dans la region centrale un nombre croissant de cartouches par des cartouches de plus gros diametre; on montre qu'a partir de mesures portant sur moins de dix pour cent du nombre total de cartouches, on peut determiner la variation de reactivite qui correspondrait au remplacement de toutes les cartouches; il est facile d'en deduire les variations du Laplacien. Resultats: les variations du Laplacien en fonction du diametre du barreau d'uranium sont: 0 (d. 26 mm), +0.065 {+-} 0.004 m{sup -2} (d. 28 mm) and +0.080 {+-} 0.008 m{sup -2} (d. 32 mm). (auteur)

Comparative study of random and uniform models for the distribution of TRISO particles in HTR-10 fuel elements

International Nuclear Information System (INIS)

Rosales, J.; Perez, J.; Garcia, C.; Munnoz, A.; Lira, C. A. B. O.

2015-01-01

TRISO particles are the specific features of HTR-10 and generally HTGR reactors. Their heterogeneity and random arrangement in graphite matrix of these reactors create a significant modeling challenge. In the simulation of spherical fuel elements using MCNPX are usually created repetitive structures using uniform distribution models. The use of these repetitive structures introduces two major approaches: the non-randomness of the TRISO particles inside the pebbles and the intersection of the pebble surface with the TRISO particles. These approaches could affect significantly the multiplicative properties of the core. In order to study the influence of these approaches in the multiplicative properties was estimated the K inf value in one pebble with white boundary conditions using 4 different configurations regarding the distribution of the TRISO particles inside the pebble: uniform hexagonal model, cubic uniform model, cubic uniform without the effect of cutting and a random distribution model. It was studied the impact these models on core scale solving the problem B1, from the Benchmark Problems presented in a Coordinated Research Program of the IAEA. (Author)

Measured and Modeled Long-Wave Infrared Signature of Quest in Q280

Science.gov (United States)

2008-03-01

l’eau chaude par rapport à l’air froid , a constitué un autre cas permet- tant de mieux comprendre les signatures infrarouge et de mettre au point des...d’intensité énergétique infrarouge à l’horizon et dans la valeur absolue de l’in- tensité énergétique de la mer : le modèle laisse prévoir...ports de l’Arctique favorise fortement d’autres recherches sur les signatures infrarouge des navires en eaux froides et dans des conditions hivernales

Study of high frequency instabilities on a cold cathode reflex discharge; Contribution a l'etude des instabilites a haute frequence dans la decharge reflex a cathodes froides

Energy Technology Data Exchange (ETDEWEB)

Gregoire, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1965-06-01

The cold cathode reflex discharge develops a cathode sheath of several hundreds of volts, which accelerates electrons released from the cathode to high velocities along the lines of the axial magnetic field. On the studied pressure range (4.10{sup -4} torr < p < 2.10{sup -2} torr) the plasma density is about 10{sup 11} cm{sup -3}. Under certain conditions high frequency (1 5000 MHz) instabilities appear. These instabilities are found to profoundly modify the mean characteristics of the discharge. In particular, particle flow across the lines of magnetic field is found to be considerably greater than that predicted by classical diffusion theory. Theoretical considerations are presented with complementary experimental results. They show that the high frequency instabilities are a result of the fast electronic assembly accelerated through the cathode sheath. (author) [French] Dans certaines conditions, qui sont precisees, des instabilites a haute frequence (1 5000 MHz) se developpent dans la decharge reflex a cathodes froides. Lorsque le plasma (n {approx_equal}10{sup 11} cm{sup -3}) est instable, les caracteristiques moyennes de la decharge sont profondement alterees. Les fuites de particules a travers les lignes de forces du champ magnetique statique applique deviennent en particulier trop importantes pour que le seul effet classique des collisions binaires puisse les expliquer. L'ionisation du gaz est assuree par une assemblee electronique qui acquiert dans les gaines cathodiques ({approx_equal} 500 volts) une vitesse, parallele au champ magnetique, importante. La discussion de resultats theoriques et une experience complementaire montrent que cette population d'electrons rapides, tres distincte de celle des electrons lents du plasma pour les pressions les plus faibles du domaine etudie (4.10{sup -4} torr < p < 2.10{sup -2} torr), est responsable des instabilites a haute frequence observees. (auteur)

A Single Dose of LSD Does Not Alter Gene Expression of the Serotonin 2A Receptor Gene (HTR2A) or Early Growth Response Genes (EGR1-3) in Healthy Subjects

Science.gov (United States)

Dolder, Patrick C.; Grünblatt, Edna; Müller, Felix; Borgwardt, Stefan J.; Liechti, Matthias E.

2017-01-01

Rationale: Renewed interest has been seen in the use of lysergic acid diethylamide (LSD) in psychiatric research and practice. The repeated use of LSD leads to tolerance that is believed to result from serotonin (5-HT) 5-HT2A receptor downregulation. In rats, daily LSD administration for 4 days decreased frontal cortex 5-HT2A receptor binding. Additionally, a single dose of LSD acutely increased expression of the early growth response genes EGR1 and EGR2 in rat and mouse brains through 5-HT2A receptor stimulation. No human data on the effects of LSD on gene expression has been reported. Therefore, we investigated the effects of single-dose LSD administration on the expression of the 5-HT2A receptor gene (HTR2A) and EGR1-3 genes. Methods: mRNA expression levels were analyzed in whole blood as a peripheral biomarker in 15 healthy subjects before and 1.5 and 24 h after the administration of LSD (100 μg) and placebo in a randomized, double-blind, placebo-controlled, cross-over study. Results: LSD did not alter the expression of the HTR2A or EGR1-3 genes 1.5 and 24 h after administration compared with placebo. Conclusion: No changes were observed in the gene expression of LSD’s primary target receptor gene or genes that are implicated in its downstream effects. Remaining unclear is whether chronic LSD administration alters gene expression in humans. PMID:28701958

Preliminary design study of pebble bed reactor HTR-PM base using once-through-then-out fuel recirculation

International Nuclear Information System (INIS)

Topan Setiadipura; Jupiter S Pane; Zuhair

2016-01-01

Pebble Bed Reactor (PBR) is one of the advanced reactor type implementing strong passive safety feature. In this type of design has the potential to do a cogeneration useful for the treatment of various minerals in various islands in Indonesia. The operation of the PBR can be simplified by implementing once-through-then-out (OTTO) fuel recirculation scheme in which pebble fuel only pass the core once time. The purpose of this research is to understand quantitative influence of the changing of fuel element recirculation on the PBR core performance and to find preliminary optimization design of PBR type reactor with OTTO recirculation scheme. PEBBED software was used to find PBR equilibrium core. The calculation result gives quantitative data on the impact of implementing a different fuel recirculation, especially using OTTO scheme. Furthermore, an early optimized PBR design based on HTR-PM using OTTO scheme was obtained where the power must be downgraded into 115 MWt in order to preserve the safety feature. The simplicity of the reactor operation and the reduction of reactor component with OTTO scheme still make this early optimized design an interesting alternative design, despite its power reduction from the reference design. (author)

Benchmark calculation for the steady-state temperature distribution of the HTR-10 under full-power operation

International Nuclear Information System (INIS)

Chen Fubing; Dong Yujie; Zheng Yanhua; Shi Lei; Zhang Zuoyi

2009-01-01

Within the framework of a Coordinated Research Project on Evaluation of High Temperature Gas-Cooled Reactor Performance (CRP-5) initiated by the International Atomic Energy Agency (IAEA), the calculation of steady-state temperature distribution of the 10 MW High Temperature Gas-Cooled Reactor-Test Module (HTR-10) under its initial full power experimental operation has been defined as one of the benchmark problems. This paper gives the investigation results obtained by different countries who participate in solving this benchmark problem. The validation works of the THERMIX code used by the Institute of Nuclear and New Energy Technology (INET) are also presented. For the benchmark items defined in this CRP, various calculation results correspond well with each other and basically agree the experimental results. Discrepancies existing among various code results are preliminarily attributed to different methods, models, material properties, and so on used in the computations. Temperatures calculated by THERMIX for the measuring points in the reactor internals agree well with the experimental values. The maximum fuel center temperatures calculated by the participants are much lower than the limited value of 1,230degC. According to the comparison results of code-to-code as well as code-to-experiment, THERMIX is considered to reproduce relatively satisfactory results for the CRP-5 benchmark problem. (author)

Possible future roles for the high temperature gas-cooled reactor (HTR) in the community

International Nuclear Information System (INIS)

1978-11-01

Possible roles for HTR in different European nuclear energy strategies are examined from the standpoint of long-term uranium and capital conservation. Two different growth scenarios for European Community electrical energy demand have been assumed (fig. 1). Both curves have been developed from existing short-term forecasts and commitments already made by member states. The lower curve represents a realistic minimum development of per capita energy demand from 3.3 toe/y in 1975 to a ceiling of 6.1 toe/year in 2035 that still lies 30% below current U.S. consumption. Electricity is assumed to increase its share of the total energy market from 28% (1976) to 35%. The higher growth curve represents an increase in overall energy consumption to a level corresponding to 8 toe per capita per year, while the electricity share increase to 67% of the overall demand. It is appreciated that such an increase in the electricity share of the overall demand is unrealistic; its consideration in the present study must therefore be regarded as tending to explore an extreme case of electricity demand growth. A long-term view is taken to show how far future developments are affected by decisions taken in the medium-term. Saturation is assumed in order to force complete development of steady state conditions, in which the relationship between different reactors can be readily discerned and capital needs compared. At saturation uranium price and availability become unimportant in systems containing thermal and breeder reactors in symbiosis

Nonlinear finite element analysis of a test on the mechanical mechanism of the half-steel-concrete composite beam in HTR-PM

International Nuclear Information System (INIS)

Sun Feng; Pan Rong

2014-01-01

According to a large-span half-steel-concrete (HSC) composited beam in the composited roof in the HTR-PM, a 1:3 scale specimen is investigated by the static load test. By analyzing the loading, deflection, strain and fracture development of the specimen in the process, studying the mechanical characteristics and failure pattern of such components. The ANSYS finite element software is utilized in this paper to analyze the nonlinearity behavior of the HSC beam specimen, and through comparing the experimental results and the numerical simulation, it can be illustrated that the finite element model can simulate the HSC beam accurately. From the test results, it can be concluded that by means of appropriate shear connection and anchorage length, steel plate and concrete can work together very well and the HSC beam has good load carrying capacity and ductility. These conclusions can serve as a preliminary design reference for the large span half-steel-concrete composite beam in NPP. (author)

The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and antisocial personality disorder in male heroin-dependent Chinese subjects.

Science.gov (United States)

Yang, Mei; Kavi, Vasish; Wang, Wenfu; Wu, Zhimei; Hao, Wei

2012-03-30

To explore the association between the 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR polymorphisms with comorbidity of antisocial personality disorder in male heroin-dependent patients. In case control study, we compared the polymorphic distributions of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR in 588 male heroin-dependent patients (including 311 patients with antisocial personality disorder and 277 patients without antisocial personality disorder) and 194 normal males by genotypes, alleles, and interaction between genes. Between male heroin-dependent patients with antisocial personality disorder and normal males, and between male heroin-dependent patients with and without antisocial personality disorder, the distributions of 5-HTTVNTR polymorphic genotypes and alleles were in statistical significance. Individuals carrying 10R allele were in higher risk of the comorbidity of antisocial personality disorder and heroin dependence. By MDR analyses, the interaction between 5-HTTVNTR and DATVNTR was close to statistical significance in predicting the risk of antisocial personality disorder in male heroin dependent patients. In male heroin dependent patients, individuals carrying 5-HTTVNTR 10R allele or/and DATVNTR 9R allele were in higher risks of co-occurring antisocial personality disorder, while individuals with 5-HTTVNTR 12R/12R and DATVNTR 10R/10R genotypes together were in lower risks of antisocial personality disorder. 5-HTTVNTR, and the interaction between 5-HTTVNTR and DATVNTR may be associated with the comorbidity of antisocial personality disorder in male heroin-dependent patients. Copyright © 2011 Elsevier Inc. All rights reserved.

Association between the HTR2C rs1414334 C/G gene polymorphism and the development of the metabolic syndrome in patients treated with atypical antipsychotics

Directory of Open Access Journals (Sweden)

José María Rico-Gomis

2016-07-01

Full Text Available Few studies have assessed the association between the rs1414334 C/G polymorphism in the HTR2C gene and the development of the metabolic syndrome in patients treated with atypical antipsychotics. To provide further evidence, a cross-sectional study was conducted in Spain between 2012 and 2013 in 166 patients with these characteristics. In these patients, the association between the polymorphism and the presence of the metabolic syndrome was determined by implementing binary logistic regression models adjusted for variables associated with the metabolic syndrome. We did not confirm previous claims that the C allele of the polymorphism was linked to the metabolic syndrome: the association was in the opposite direction and non-significant. This conclusion held after taking gender and lifestyle variables into account.

Safety study for HTR concepts under German site conditions. Main volume for phase I B

International Nuclear Information System (INIS)

1981-12-01

Within the spectrum of accidents, core heat-up, caused by failure of the power supplies to the reactor or by interruption of the cooling system, is of major significance. This accident causes no serious effects to the environment if the reactor containment building remains intact; however, in certain infrequent events the containment building could fail due to overpressure after about one week at the earliest and a significant environmental hazard would ensue. The other accidents - depressurisation, water and air ingress - are by comparison of distinctly lower importance to the overall risk. A common feature of all the significant accidents is that within the first five hours the maximum release of radioactivity to the reactor containment building is the inventory of the primary circuit, while the fission product inventory of the core is securely retained. The accidents investigated are characterised in the study by the probability of occurrence, by the types and quantities of the fission products released and by the period of release. It was stipulated that in this phase of the study the health risk to the neighbouring population should not be determined. However, the estimated quantities of released nuclides and their associated time of release lead to the conclusion that the worst possible damage to the environment is very limited. This arises from the inherent safety characteristics of the HTR and the comparatively long period available for counter measures. (orig./HP) [de

Results of cost estimates for the exploitation of the Natuna gas field in Indonesia using the HTR: A new momentum for commercialization

International Nuclear Information System (INIS)

Barnert, H.

1997-01-01

The results of a simplified method for cost estimations are presented. The main result is: There exists a potential of economical competitiveness for the exploitation of the gas of the Natuna Gas Field in Indonesia. The potential consists in the production of Energy Alcohol from the gas of the Natuna Gas Field, making use of nuclear energy in the form of high temperature heat and electricity from the High Temperature reactor, HTR. The reason is that Energy Alcohol is a readily marketable product as a substitute for gasoline and diesel, with their relatively high market values. This is not so for methane, because of its lower market value, being used mainly in the heat market only. In the conversion process some - or a little more - of the carbondioxide CO 2 , the main constituent of the gas of the Natuna Gas Field, is used; the competitiveness of the product decreases with the increasing consumption of CO 2

ASSOCIATION STUDY OF 5-HTR2A-1438A/G,COMTVAL158MET,MAOA-LPR,DATVNTR AND 5-HTTVNTR POLYMORPHISMS WITH COOCCURRENCE HEROIN DEPENDENCE AND ANTISOCIAL PERSONALITY DISORDERS IN MALES%5-HTR2A-1438A/G、COMTVal158Met、MAOA-LPR、5-HTTVNTR 、DATVNTR与男性海洛因依赖共患反社会性人格障碍的关联研究*

Institute of Scientific and Technical Information of China (English)

杨梅; 郝伟; 邬志美; 王文甫; 周旭辉; 姜国清; 汤美云; 黄健

2010-01-01

目的:探讨5-HTR2A受体基因(5-hydroxytryptamine receptor 2A gene,5-HTR2A)-1438A/G多态性(5-HTR2A-1438A/G,rs6311)、儿茶酚-O-甲基转移酶基因(catechol-O-methyltransferase gene,COMT)Val158Met多态性(COMTVal158Met,rs4680)、单胺氧化酶A基因(monoamine oxidase A gene,MAOA)启动子区可变数目串联重复序列(variable number of tandem repeats,VNTR) 多态性(称为MAOA多型变异区段,MAOA-linked polymorphic region,MAOA-LPR))、多巴胺转运体基因(dopamine transporter gene,DAT)外显子15靠近3′端的可变数目串联重复序列多态性(DATVNTR)、5-HT转运体基因(5-hydroxytryptamine transporter gene,5-HTT)内含子2内可变数目串联重复序列多态性(5-HTTVNTR)及以上各位点之间的交互作用与男性海洛因依赖共患反社会性人格障碍有无关联.方法:采用病历对照关联分析,应用聚合酶链式反应和连接酶检测反应(polymerase chain reaction-ligase detection reaction,PCR-LDR)技术检测588例男性海洛因依赖者(其中共患反社会性人格障碍者311例,不共患反社会性人格障碍者277例)和194例健康男性5-HTR2A-1438A/G、COMTVal158Met、MAOA-LPR、DATVNTR、5-HTTVNTR多态性的基因型,对各位点的基因型频率、等位基因频率及各位点之间的交互作用进行疾病关联分析.结果:共患反社会性人格障碍的男性海洛因依赖者与健康男性间,共患与不共患反社会性人格障碍的男性海洛因依赖者间在5-HTTVNTR的基因型和等位基因频率上均有统计学差异,携带10次重复序列(10-repeats,10R)等位基因的个体共患海洛因依赖和反社会性人格障碍风险相对较大.经MDR分析,在男性海洛因依赖者中,HTTVNTR与DATVNTR的二因模型子对反社会性人格障碍的预测准确度最大,符号检验有统计学差异,校正后P值为0.067,接近显著性差异.携带5-HTTVNTR等位基因10R和/或携带DATVNTR等位基因9R的个体共患反社会性人格�

Experimental and analytical studies for the validation of HTR-VGD and primary cell passive decay heat removal. Supplement. Calculations

International Nuclear Information System (INIS)

Geiss, M.; Giannikos, A.; Hejzlar, P.; Kneer, A.

1993-04-01

The alternative concept for a modular HTR-reactor design by Siempelkamp, Krefeld, using a prestressed cast iron vessel (VGD) combined with a cast iron/concrete module for the primary cell with integrated passive decay heat removal system was fully qualified with respect to operational and accidental thermal loads. The main emphasis was to confirm and validate the passive decay heat removal capability. An experimental facility (INWA) was designed, instrumented and operated with an appropriate electrical heating system simulating steady-state operational and transient accidental thermal loads. The experiments were accompanied by extensive computations concerning the combination of conductive, radiative and convective energy transport mechanisms in the different components of the VGD/primary cell structures, as well as elastic-plastic stress analyses of the VGD. In addition, a spectrum of potential alternatives for passive energy removed options have been parametrically examined. The experimental data clearly demonstrate that the proposed Siempelkamp-design is able to passively and safely remove the decay heat for operational and accidental conditions without invalidating technological important thermal limits. This also holds in case of failures of both the natural convection system and ultimate heat sink by outside concrete water film cooling. (orig./HP) [de

La quête des températures ultrabasses

OpenAIRE

Suchet , Daniel

2018-01-01

International audience; Des vendeurs de glace à l'industrie cryogénique, le froid est souvent perçu comme un produit. Pour le physicien, le froid, réduction de l'agitation aléatoire des particules, apparaît plutôt comme une force productrice, capable de faire émerger des structures complexes et de métamorphoser les propriétés des objets. Les basses températures ont été l'enjeu d'une course effrénée dont la première phase a pris fin en 1908 avec la liquéfaction de l'ensemble des gaz connus. Lo...

IMPLEMENTASI HUTAN TANAMAN RAKYAT DI KABUPATEN PESISIR BARAT-LAMPUNG DAN KABUPATEN TEBO-JAMBI (Implementation of Community Timber Plantation in Pesisir Barat District-Lampung and Tebo District-Jambi

Directory of Open Access Journals (Sweden)

Sanudin Sanudin

2015-11-01

Full Text Available ABSTRAK Pembangunan Hutan Tanaman Rakyat (HTR merupakan upaya pemerintah dalam rangka meningkatkan partisipasi dan tanggung jawab masyarakat sekitar hutan dalam pengelolaan hutan dengan didasari oleh prinsip-prinsip pengelolaan hutan produksi. Penelitian ini bertujuan untuk mengetahui implementasi HTR pada koperasi yang mendapatkan Pinjaman Dana Bergulir (PDB dari Pusat Pembiyaan Pembangunan Hutan (PPPH. Penelitian dilakukan pada bulan Oktober 2014 – Januari 2015 di KLL, Kabupaten Pesisir Barat, Provinsi Lampung dan KMB, Kabupaten Tebo, Provinsi Jambi. Data primer seperti pengelolaan HTR, kinerja PDB, dan permasalahan yang dihadapi dikumpulkan melalui wawancara dengan pengelola koperasi, pejabat di Balai Pemantauan Pemanfaatan Hutan Produksi (BP2HP, Dinas Kehutanan Kabupaten/Provinsi, petani dan melalui pengamatan lapangan. Data yang terkumpul kemudian dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa tingkat penerimaan masyarakat terhadap program HTR masih rendah akibat kurang maksimalnya kegiatan sosialisasi. Hal ini menyebabkan konflik dalam implementasi HTR. Berdasarkan kondisi lapangan dan tantangan yang dihadapi, tingkat keberhasilan implementasi HTR di KLL sangat tergantung kepada kesungguhan pihak koperasi dalam melakukan teknik silvikultur dalam pengelolaan hutan berbasis masyarakat, sementara implementasi HTR di KMB dari sisi silvikultur sudah cukup baik namun perlu pendekatan persuasif dalam penanganan masalah sosial. Sifat dari PDB adalah untuk memperkuat modal, oleh karena itu koperasi HTR harus mencari sumber permodalan lainnya baik lembaga keuangan maupun pihak swasta lainnya.   ABSTRACT Development of Community Timber Plantation (HTR is government effort to increase participation and responsibility of community around the forest on forest management based on management production forest. This study aimed is to know HTR implementation of cooperative which get revolving fund scheme (PDB-HTR from Forest Development

High Temperature reactors status 1977

International Nuclear Information System (INIS)

Ekholm, R.; Bosaeus, J.; Carleson, G.; Gelin, R.; Jirlow, K.; Linder, S.; Menon, S.; Runfors, U.; Vieider, G.

1978-03-01

The objective of this report is to summarize the current state-of-the-art of HTR technology as part of follow-up studies of the development of advanced fission reactor systems. These studies have been performed at AB Atomenergi since fiscal year 1975/76 and are financed by governmental funds for energy R and D. In this report emphasis is given to the following main aspects of the HTR development: - a survey of the major HTR - R and D programmes; - the description of HTR technology including remaining development problems and uncertainties; - the analysis of the safety and environmental characteristics of the HTR systems; - the analysis of the incentives for the introduction of various HTR types. The report contains also information kindly provided directly by experts from several organisations developing the HTR-systems

Combined deterministic and stochastic approaches applied to the food cold chain

OpenAIRE

Laguerre , O.; Hoang , M.H.; Derens , E.; Alvarez , G.; Flick , D.

2012-01-01

International audience; Plusieurs enquêtes ont montré que la température de produits dans les 3 dernières étapes de la chaîne du froid est problématique: meuble frigorifique de vente, transport par les consommateurs après l’achat et réfrigérateur domestique. Cette étude a été effectuée pour proposer une méthodologie de prédiction de l'évolution de la température du produit et de la charge microbienne tout au long de la chaine du froid. Les modèles déterministes développés prennent en compte l...

Optical lattice clock with strontium atoms: a second generation of cold atom clocks; Horloge a reseau optique au strontium: une 2. generation d'horloges a atomes froids

Energy Technology Data Exchange (ETDEWEB)

Le Targat, R

2007-07-15

Atomic fountains, based on a microwave transition of Cesium or Rubidium, constitute the state of the art atomic clocks, with a relative accuracy close to 10{sup -16}. It nevertheless appears today that it will be difficult to go significantly beyond this level with this kind of device. The use of an optical transition, the other parameters being unchanged, gives hope for a 4 or 5 orders of magnitude improvement of the stability and of the relative uncertainty on most systematic effects. As for motional effects on the atoms, they can be controlled on a very different manner if they are trapped in an optical lattice instead of experiencing a free ballistic flight stage, characteristic of fountains. The key point of this approach lies in the fact that the trap can be operated in such a way that a well chosen, weakly allowed, J=0 {yields} J=0 clock transition can be free from light shift effects. In this respect, the strontium atom is one of the most promising candidate, the 1S{sub 0} {yields} 3P{sub 0} transition has a natural width of 1 mHz, and several other easily accessible transitions can be used to efficiently laser cool atoms down to 10 {mu}K. This thesis demonstrates the experimental feasibility of an optical lattice clock based on the strontium atom, and reports on a preliminary evaluation of the relative accuracy with the fermionic isotope {sup 87}Sr, at a level of a few 10{sup -15}. (author)

Programmes and projects for high-temperature reactor development

International Nuclear Information System (INIS)

Bogusch, Edgar; Hittner, Dominique

2009-01-01

An increasing attention has to be recognised worldwide on the development of High-Temperature Reactors (HTR) which has started in Germany and other countries in the 1970ies. While pebble bed reactors with spherical fuel elements have been developed and constructed in Germany, countries such as France, the US and Russia investigated HTR concepts with prismatic block-type fuel elements. The concept of a modular HTR formerly developed by Areva NP was an essential basis for the HTR-10 in China. A pebble bed HTR for electricity production is developed in South Africa. The construction is planned after the completion of the licensing procedure. Also the US is planning an HTR under the NGNP (Next Generation Nuclear Plant) Project. Due to the high temperature level of the helium coolant, the HTR can be used not only for electricity production but also for supply of process heat. Including its inherent safety features the HTR is an attractive candidate for heat supply to various types of plants e.g. for hydrogen production or coal liquefactions. The conceptual design of an HTR with prismatic fuel elements for the cogeneration of electricity and process heat has been developed by Areva NP. On the European scale the HTR development is promoted by the RAPHAEL (ReActor for Process heat, Hydrogen And ELectricity generation) project. RAPHAEL is an Integrated Project of the Euratom 6th Framework Programme for the development of technologies towards a Very High-Temperature Reactor (VHTR) for the production of electricity and heat. It is financed jointly by the European Commission and the partners of the HTR Technology Network (HTR-TN) and coordinated by Areva NP. The RAPHAEL project not only promotes HTR development but also the cooperation with other European projects such as the material programme EXTREMAT. Furthermore HTR technology is investigated in the frame of Generation IV International Forum (GIF). The development of a VHTR with helium temperatures above 900 C for the

Hyperfunction of muscarinic receptor maintains long-term memory in 5-HT4 receptor knock-out mice.

Directory of Open Access Journals (Sweden)

Luis Segu

Full Text Available Patients suffering from dementia of Alzheimer's type express less serotonin 4 receptors (5-HTR(4, but whether an absence of these receptors modifies learning and memory is unexplored. In the spatial version of the Morris water maze, we show that 5-HTR(4 knock-out (KO and wild-type (WT mice performed similarly for spatial learning, short- and long-term retention. Since 5-HTR(4 control mnesic abilities, we tested whether cholinergic system had circumvented the absence of 5-HTR(4. Inactivating muscarinic receptor with scopolamine, at an ineffective dose (0.8 mg/kg to alter memory in WT mice, decreased long-term but not short-term memory of 5-HTR(4 KO mice. Other changes included decreases in the activity of choline acetyltransferase (ChAT, the required enzyme for acetylcholine synthesis, in the septum and the dorsal hippocampus in 5-HTR(4 KO under baseline conditions. Training- and scopolamine-induced increase and decrease, respectively in ChAT activity in the septum in WT mice were not detected in the 5-HTR(4 KO animals. Findings suggest that adaptive changes in cholinergic systems may circumvent the absence of 5-HTR(4 to maintain long-term memory under baseline conditions. In contrast, despite adaptive mechanisms, the absence of 5-HTR(4 aggravates scopolamine-induced memory impairments. The mechanisms whereby 5-HTR(4 mediate a tonic influence on ChAT activity and muscarinic receptors remain to be determined.

Development status and operational features of the high temperature gas-cooled reactor. Final report

International Nuclear Information System (INIS)

Winkleblack, R.K.

1976-04-01

The objective of this study is to investigate the maturity of HTR-technology and to look out for possible technical problems, concerning introduction of large HTR power plants into the market. Further state and problems of introducing and closing the thorium fuel cycle is presented and judged. Finally, the state of development of advanced HTR-concepts for electricity production, the direct cycle HTR with helium turbine, and the gas-cooled fast breeder is discussed. In preparing the study, both HTR concepts with spherical and block-type fuel elements have been considered