WorldWideScience

Sample records for research update

  1. Research reactor fuel - an update

    International Nuclear Information System (INIS)

    Finlay, M.R.; Ripley, M.I.

    2003-01-01

    In the two years since the last ANA conference there have been marked changes in the research reactor fuel scene. A new low-enriched uranium (LEU) fuel, 'monolithic' uranium molybdenum, has shown such promise in initial trials that it may be suitable to meet the objectives of the Joint Declaration signed by Presidents Bush and Putin to commit to converting all US and Russian research reactors to LEU by 2012. Development of more conventional aluminium dispersion UMo LEU fuel has continued in the meantime and is entering the final qualification stage of multiple full sized element irradiations. Despite this progress, the original 2005 timetable for UMo fuel qualification has slipped and research reactors, including the RRR, may not convert from silicide to UMo fuel before 2007. The operators of the Swedish R2 reactor have been forced to pursue the direct route of qualifying a UMo lead test assembly (LTA) in order to meet spent fuel disposal requirements of the Swedish law. The LTA has recently been fabricated and is expected to be loaded shortly into the R2 reactor. We present an update of our previous ANA paper and details of the qualification process for UMo fuel

  2. UPDATE: Applications of Research in Music Education. UPDATE Yearbook

    Science.gov (United States)

    Rowman & Littlefield Education, 2005

    2005-01-01

    The Fall 2004 and Spring 2005 issues of "UPDATE: Applications of Research in Music Education," in one print volume, presents hard facts and statistical data in a style that can be easily understood and appreciated by music researchers, teachers, graduates, and undergraduates alike. Includes advice to first-year music teachers, instrument…

  3. Stuttering: Clinical and research update.

    Science.gov (United States)

    Perez, Hector R; Stoeckle, James H

    2016-06-01

    To provide an update on the epidemiology, genetics, pathophysiology, diagnosis, and treatment of developmental stuttering. The MEDLINE and Cochrane databases were searched for past and recent studies on the epidemiology, genetics, pathophysiology, diagnosis, and treatment of developmental stuttering. Most recommendations are based on small studies, limited-quality evidence, or consensus. Stuttering is a speech disorder, common in persons of all ages, that affects normal fluency and time patterning of speech. Stuttering has been associated with differences in brain anatomy, functioning, and dopamine regulation thought to be due to genetic causes. Attention to making a correct diagnosis or referral in children is important because there is growing consensus that early intervention with speech therapy for children who stutter is critical. For adults, stuttering can be associated with substantial psychosocial morbidity including social anxiety and low quality of life. Pharmacologic treatment has received attention in recent years, but clinical evidence is limited. The mainstay of treatment for children and adults remains speech therapy. A growing body of research has attempted to uncover the pathophysiology of stuttering. Referral for speech therapy remains the best option for children and adults. Copyright© the College of Family Physicians of Canada.

  4. Argo packing friction research update

    International Nuclear Information System (INIS)

    VanTassell, D.M.

    1994-01-01

    This paper focuses on the issue of valve packing friction and its affect on the operability of motor- and air-operated valves (MOVs and AOVs). At this time, most nuclear power plants are required to perform postmaintenance testing following a packing adjustment or replacement. In many cases, the friction generated by the packing does not impact the operability window of a valve. However, to date there has not been a concerted effort to substantiate this claim. To quantify the effects of packing friction, it has become necessary to develop a formula to predict the friction effects accurately. This formula provides a much more accurate method of predicting packing friction than previously used factors based strictly on stem diameter. Over the past 5 years, Argo Packing Company has been developing and testing improved graphite packing systems at research facilities, such as AECL Chalk River and Wyle Laboratories. Much of this testing has centered around reducing and predicting friction that is related to packing. In addition, diagnostic testing for Generic Letter 89-10 MOVs and AOVs has created a significant data base. In July 1992 Argo asked several utilities to provide running load data that could be used to quantify packing friction repeatability and predictability. This technical paper provides the basis to predict packing friction, which will improve calculations for thrust requirements for Generic Leter 89-10 and future AOV programs. In addition, having an accurate packing friction formula will improve packing performance when low running loads are identified that would indicate insufficient sealing force

  5. Severe Accident Research Program plan update

    International Nuclear Information System (INIS)

    1992-12-01

    In August 1989, the staff published NUREG-1365, ''Revised Severe Accident Research Program Plan.'' Since 1989, significant progress has been made in severe accident research to warrant an update to NUREG-1365. The staff has prepared this SARP Plan Update to: (1) Identify those issues that have been closed or are near completion, (2) Describe the progress in our understanding of important severe accident phenomena, (3) Define the long-term research that is directed at improving our understanding of severe accident phenomena and developing improved methods for assessing core melt progression, direct containment heating, and fuel-coolant interactions, and (4) Reflect the growing emphasis in two additional areas--advanced light water reactors, and support for the assessment of criteria for containment performance during severe accidents. The report describes recent major accomplishments in understanding the underlying phenomena that can occur during a severe accident. These include Mark I liner failure, severe accident scaling methodology, source term issues, core-concrete interactions, hydrogen transport and combustion, TMI-2 Vessel Investigation Project, and direct containment heating. The report also describes the major planned activities under the SARP over the next several years. These activities will focus on two phenomenological issues (core melt progression, and fuel-coolant interactions and debris coolability) that have significant uncertainties that impact our understanding and ability to predict severe accident phenomena and their effect on containment performance SARP will also focus on severe accident code development, assessment and validation. As the staff completes the research on severe accident issues that relate to current generation reactors, continued research will focus on efforts to independently evaluate the capability of new advanced light water reactor designs to withstand severe accidents

  6. Federal Geothermal Research Program Update, FY 2000

    Energy Technology Data Exchange (ETDEWEB)

    Renner, Joel Lawrence

    2001-08-01

    The Department of Energy's Geothermal Program serves two broad purposes: 1) to assist industry in overcoming near-term barriers by conducting cost-shared research and field verification that allows geothermal energy to compete in today's aggressive energy markets; and 2) to undertake fundamental research with potentially large economic payoffs. The four categories of work used to distinguish the research activities of the Geothermal Program during FY 2000 reflect the main components of real-world geothermal projects. These categories form the main sections of the project descriptions in this Research Update. Exploration Technology research focuses on developing instruments and techniques to discover hidden hydrothermal systems and to explore the deep portions of known systems. Research in geophysical and geochemical methods is expected to yield increased knowledge of hidden geothermal systems. Reservoir Technology research combines laboratory and analytical investigations with equipment development and field testing to establish practical tools for resource development and management for both hydrothermal reservoirs and enhanced geothermal systems. Research in various reservoir analysis techniques is generating a wide range of information that facilitates development of improved reservoir management tools. Drilling Technology focuses on developing improved, economic drilling and completion technology for geothermal wells. Ongoing research to avert lost circulation episodes in geothermal drilling is yielding positive results. Conversion Technology research focuses on reducing costs and improving binary conversion cycle efficiency, to permit greater use of the more abundant moderate-temperature geothermal resource, and on the development of materials that will improve the operating characteristics of many types of geothermal energy equipment. Increased output and improved performance of binary cycles will result from investigations in heat cycle research.

  7. Federal Geothermal Research Program Update - Fiscal Year 2001

    Energy Technology Data Exchange (ETDEWEB)

    Laney, P.T.

    2002-08-31

    This Federal Geothermal Program Research Update reviews the specific objectives, status, and accomplishments of DOE's Geothermal Program for Federal Fiscal Year (FY) 2001. The information contained in this Research Update illustrates how the mission and goals of the Office of Geothermal Technologies are reflected in each R&D activity. The Geothermal Program, from its guiding principles to the most detailed research activities, is focused on expanding the use of geothermal energy.

  8. USMARC update on swine reproduction research

    Science.gov (United States)

    Swine research at USMARC has continued to focus on meat quality, improvement of genomic resources and reproduction, specifically estrus traits, sow longevity and lifetime productivity. This report will focus on research in behavioral anestrus in gilts. Gilts that reach puberty at an earlier age are ...

  9. Transcutaneous Electrical Nerve Stimulation: Research Update.

    Science.gov (United States)

    Johns, Florene Carnicelli

    Currently, research is being performed in the area of nonsurgical and nonchemical means for influencing the body's threshold for pain. Today, transcutaneous electrical nerve stimulation (TENS) is being widely used for this purpose. Application of this treatment can be confusing, however, because determining such things as selection of the proper…

  10. Early Brain Development Research Review and Update

    Science.gov (United States)

    Schiller, Pam

    2010-01-01

    Thanks to imaging technology used in neurobiology, people have access to useful and critical information regarding the development of the human brain. This information allows them to become much more effective in helping children in their early development. In fact, when people base their practices on the findings from medical science research,…

  11. Leisure and the Elderly. Research Update.

    Science.gov (United States)

    Siegenthaler, K. L.

    1996-01-01

    Research shows a relationship between older adults' leisure involvement and life satisfaction. Individuals who participate more frequently and in a greater variety of activities experience greater psychological well-being. The paper discusses successful aging and leisure participation, provides current definitions, and examines perceptions of…

  12. Pediatric headache: update on recent research.

    Science.gov (United States)

    Hershey, Andrew D

    2012-02-01

    Primary headache are one of the most common health complaints in children and adolescents, yet there remain significant gaps in our understanding of the underlying pathophysiology of these conditions. Recently, there have been several areas of research that have assisted with filling this gap in our knowledge. These areas include a better understanding of the disease characteristics including additional associated symptoms and the refinement of the description of related conditions and comorbidities; continued examination of the epidemiology of primary headaches; the progression of migraine across these developmental ages; the molecular and physiological changes; and the potential role for vitamins and cofactor deficiencies in the pathophysiology. These studies continue to add to our fund of knowledge on the basis of migraine and tension-type headache as primary neurological conditions and their impact on the developing brain. © 2012 American Headache Society.

  13. Attachment and eating disorders: a research update.

    Science.gov (United States)

    Tasca, Giorgio A

    2018-03-16

    Prominent models of eating disorders tend to focus on cognitive and behavioral features, but tend not to consider important developmental issues related to affect regulation, interpersonal style, self concept, and mentalization-all of which are well conceptualized within attachment theory. Higher levels of attachment insecurity across diagnoses are related to greater eating disorder symptoms. Low parental care and early trauma may lead to attachment insecurity that then might lead to greater eating disorder symptoms. The association between insecure attachment and eating disorder severity is likely mediated by affect dysregulation and perfectionism. Recent research using the Adult Attachment Interview highlights the importance of reflective functioning in predicting treatment response and therapeutic processes, and on the utility of therapies that increase mentalization. Copyright © 2018 Elsevier Ltd. All rights reserved.

  14. Federal Geothermal Research Program Update Fiscal Year 1999

    Energy Technology Data Exchange (ETDEWEB)

    2004-02-01

    The Department of Energy (DOE) and its predecessors have conducted research and development (R&D) in geothermal energy since 1971. To develop the technology needed to harness the Nation's vast geothermal resources, DOE's Office of Geothermal and Wind Technologies oversees a network of national laboratories, industrial contractors, universities, and their subcontractors. The following mission and goal statements guide the overall activities of the Office of Geothermal and Wind Technologies. This Federal Geothermal Program Research Update reviews the specific objectives, status, and accomplishments of DOE's Geothermal Program for Federal Fiscal Year (FY) 1999. The information contained in this Research Update illustrates how the mission and goals of the Office of Geothermal and Wind Technologies are reflected in each R&D activity. The Geothermal Program, from its guiding principles to the most detailed research activities, is focused on expanding the use of geothermal energy.

  15. Update on the Health Services Research Doctoral Core Competencies.

    Science.gov (United States)

    Burgess, James F; Menachemi, Nir; Maciejewski, Matthew L

    2018-03-13

    To present revised core competencies for doctoral programs in health services research (HSR), modalities to deliver these competencies, and suggested methods for assessing mastery of these competencies. Core competencies were originally developed in 2005, updated (but unpublished) in 2008, modestly updated for a 2016 HSR workforce conference, and revised based on feedback from attendees. Additional feedback was obtained from doctoral program directors, employer/workforce experts and attendees of presentation on these competencies at the AcademyHealth's June 2017 Annual Research Meeting. The current version (V2.1) competencies include the ethical conduct of research, conceptual models, development of research questions, study designs, data measurement and collection methods, statistical methods for analyzing data, professional collaboration, and knowledge dissemination. These competencies represent a core that defines what HSR researchers should master in order to address the complexities of microsystem to macro-system research that HSR entails. There are opportunities to conduct formal evaluation of newer delivery modalities (e.g., flipped classrooms) and to integrate new Learning Health System Researcher Core Competencies, developed by AHRQ, into the HSR core competencies. Core competencies in HSR are a continually evolving work in progress because new research questions arise, new methods are developed, and the trans-disciplinary nature of the field leads to new multidisciplinary and team building needs. © Health Research and Educational Trust.

  16. Research Update on Extreme-Mass-Ratio Inspirals

    International Nuclear Information System (INIS)

    Amaro-Seoane, Pau; Gair, Jonathan R; Pound, Adam; Hughes, Scott A; Sopuerta, Carlos F

    2015-01-01

    The inspirals of stellar-mass mass compact objects into massive black holes in the centres of galaxies are one of the most important sources of gravitational radiation for space- based detectors like LISA or eLISA. These extreme-mass-ratio inspirals (EMRIs) will enable an ambitious research program with implications for astrophysics, cosmology, and fundamental physics. This article is a summary of the talks delivered at the plenary session on EMRIs at the 10th International LISA Symposium. It contains research updates on the following topics: astrophysics of EMRIs; EMRI science potential; and EMRI modeling. (paper)

  17. A research update for southeast poultry research laboratory

    Science.gov (United States)

    The Southeast Poultry Research Laboratory continues with their modernization plan. The 35% architectural drawings have been completed and the project is currently out for bid for the completion of the design and building of the new facility. Research activities in the Exotic and Emerging Avian Vir...

  18. Federal Geothermal Research Program Update Fiscal Year 2003

    Energy Technology Data Exchange (ETDEWEB)

    2004-03-01

    The Department of Energy (DOE) and its predecessors have conducted research and development (R&D) in geothermal energy since 1971. To develop the technology needed to harness the Nation's vast geothermal resources, DOE's Office of Geothermal Technologies oversees a network of national laboratories, industrial contractors, universities, and their subcontractors. The following mission and goal statements guide the overall activities of the Office. The goals are: (1) Reduce the levelized cost of generating geothermal power to 3-5 cents per kWh by 2007; (2) Double the number of States with geothermal electric power facilities to eight by 2006; and (3) Supply the electrical power or heat energy needs of 7 million homes and businesses in the United States by 2010. This Federal Geothermal Program Research Update reviews the accomplishments of DOE's Geothermal Program for Federal Fiscal Year (FY) 2003. The information contained in this Research Update illustrates how the mission and goals of the Office of Geothermal Technologies are reflected in each R&D activity. The Geothermal Program, from its guiding principles to the most detailed research activities, is focused on expanding the use of geothermal energy. balanced strategy for the Geothermal Program.

  19. Federal Geothermal Research Program Update Fiscal Year 2002

    Energy Technology Data Exchange (ETDEWEB)

    2003-09-01

    The Department of Energy (DOE) and its predecessors have conducted research and development (R&D) in geothermal energy since 1971. To develop the technology needed to harness the Nation's vast geothermal resources, DOE's Office of Geothermal Technologies oversees a network of national laboratories, industrial contractors, universities, and their subcontractors. The goals are: (1) Double the number of States with geothermal electric power facilities to eight by 2006; (2) Reduce the levelized cost of generating geothermal power to 3-5 cents per kWh by 2007; and (3) Supply the electrical power or heat energy needs of 7 million homes and businesses in the United States by 2010. This Federal Geothermal Program Research Update reviews the specific objectives, status, and accomplishments of DOE's Geothermal Program for Federal Fiscal Year (FY) 2002. The information contained in this Research Update illustrates how the mission and goals of the Office of Geothermal Technologies are reflected in each R&D activity. The Geothermal Program, from its guiding principles to the most detailed research activities, is focused on expanding the use of geothermal energy. balanced strategy for the Geothermal Program.

  20. Research Update: Nanoscale electrochemical transistors in correlated oxides

    Directory of Open Access Journals (Sweden)

    Teruo Kanki

    2017-04-01

    Full Text Available Large reversible changes of the electronic transport properties of solid-state oxide materials induced by electrochemical fields have received much attention as a new research avenue in iontronics. In this research update, dramatic transport changes in vanadium dioxide (VO2 nanowires were demonstrated by electric field-induced hydrogenation at room temperature through the nanogaps separated by humid air in a field-effect transistor structure with planar-type gates. This unique structure allowed us to investigate hydrogen intercalation and diffusion behavior in VO2 channels with respect to both time and space. Our results will contribute to further strategic researches to examine fundamental chemical and physical properties of devices and develop iontronic applications, as well as offering new directions to explore emerging functions for sensing, energy, and neuromorphologic devices combining ionic and electronic behaviors in solid-state materials.

  1. Selective mutism: an update and suggestions for future research.

    Science.gov (United States)

    Scott, Samantha; Beidel, Deborah C

    2011-08-01

    Speculation continues regarding the accurate classification of selective mutism and potential etiologic factors. Current research has shed some light on several factors that may predispose some children to this disorder, but conclusions are difficult to draw due to reliance on subjective measures, few comparison groups, and/or limited theoretical grounding. This article provides an update on recent efforts to elucidate the etiologic pathways of selective mutism and on the current debate regarding its strong overlap with anxiety disorders, most notably social phobia. An additional attempt is made to examine findings based on a developmental perspective that accounts for multiple pathways, context, and the developmental stage of the child. Emotion regulation theory is offered as a potential factor in why some children may be more vulnerable to the etiologic factors described. Suggestions for future research are offered based on this integration of information.

  2. Federal Geothermal Research Program Update Fiscal Year 2000

    Energy Technology Data Exchange (ETDEWEB)

    Renner, J.L.

    2001-08-15

    The Department of Energy's Geothermal Program serves two broad purposes: (1) to assist industry in overcoming near-term barriers by conducting cost-shared research and field verification that allows geothermal energy to compete in today's aggressive energy markets; and (2) to undertake fundamental research with potentially large economic payoffs. The four categories of work used to distinguish the research activities of the Geothermal Program during FY 2000 reflect the main components of real-world geothermal projects. These categories form the main sections of the project descriptions in this Research Update. Exploration Technology research focuses on developing instruments and techniques to discover hidden hydrothermal systems and to explore the deep portions of known systems. Research in geophysical and geochemical methods is expected to yield increased knowledge of hidden geothermal systems. Reservoir Technology research combines laboratory and analytical investigations with equipment development and field testing to establish practical tools for resource development and management for both hydrothermal reservoirs and enhanced geothermal systems. Research in various reservoir analysis techniques is generating a wide range of information that facilitates development of improved reservoir management tools. Drilling Technology focuses on developing improved, economic drilling and completion technology for geothermal wells. Ongoing research to avert lost circulation episodes in geothermal drilling is yielding positive results. Conversion Technology research focuses on reducing costs and improving binary conversion cycle efficiency, to permit greater use of the more abundant moderate-temperature geothermal resource, and on the development of materials that will improve the operating characteristics of many types of geothermal energy equipment. Increased output and improved performance of binary cycles will result from investigations in heat cycle research.

  3. Federal Geothermal Research Program Update Fiscal Year 2000; ANNUAL

    International Nuclear Information System (INIS)

    Renner, J.L.

    2001-01-01

    The Department of Energy's Geothermal Program serves two broad purposes: (1) to assist industry in overcoming near-term barriers by conducting cost-shared research and field verification that allows geothermal energy to compete in today's aggressive energy markets; and (2) to undertake fundamental research with potentially large economic payoffs. The four categories of work used to distinguish the research activities of the Geothermal Program during FY 2000 reflect the main components of real-world geothermal projects. These categories form the main sections of the project descriptions in this Research Update. Exploration Technology research focuses on developing instruments and techniques to discover hidden hydrothermal systems and to explore the deep portions of known systems. Research in geophysical and geochemical methods is expected to yield increased knowledge of hidden geothermal systems. Reservoir Technology research combines laboratory and analytical investigations with equipment development and field testing to establish practical tools for resource development and management for both hydrothermal reservoirs and enhanced geothermal systems. Research in various reservoir analysis techniques is generating a wide range of information that facilitates development of improved reservoir management tools. Drilling Technology focuses on developing improved, economic drilling and completion technology for geothermal wells. Ongoing research to avert lost circulation episodes in geothermal drilling is yielding positive results. Conversion Technology research focuses on reducing costs and improving binary conversion cycle efficiency, to permit greater use of the more abundant moderate-temperature geothermal resource, and on the development of materials that will improve the operating characteristics of many types of geothermal energy equipment. Increased output and improved performance of binary cycles will result from investigations in heat cycle research

  4. 77 FR 20006 - Reports and Updates on Programs and Research Projects

    Science.gov (United States)

    2012-04-03

    ... From the Federal Register Online via the Government Publishing Office ARCTIC RESEARCH COMMISSION Reports and Updates on Programs and Research Projects Notice is hereby given that the U.S. Arctic Research... be reports and updates on programs and research projects affecting the Arctic. If you plan to attend...

  5. Research and optimization of page updated forecast on Nutch

    Directory of Open Access Journals (Sweden)

    HU Wei

    2016-08-01

    Full Text Available Web page updated prediction method of Nutch is an adjacent method and its relevant update parameters need to be set artificially,not adaptively adjustable,and unable to cope with the differences of massive web page updates.To address this problem,this paper puts forward dynamic selection strategy to improve the method of Nutch web page updated prediction.When the historical updated web page data are insufficient,the strategy uses DBSCAN clustering algorithm based on MapReduce to reduce the number of the pages of the crawler system crawling,the update cycle of the sample web pages is used as update cycle of other pages which are in the same category.When the historical updated web page data are enough,the data are used to model with the Poisson Process,which can more accurately predict each web page update cycle.Finally the improving strategy is tested in the Hadoop distributed platform.The experimental results show that the performance of optimized web page updated prediction method is better.

  6. Computing for magnetic fusion energy research: An updated vision

    International Nuclear Information System (INIS)

    Henline, P.; Giarrusso, J.; Davis, S.; Casper, T.

    1993-01-01

    This Fusion Computing Council perspective is written to present the primary of the fusion computing community at the time of publication of the report necessarily as a summary of the information contained in the individual sections. These concerns reflect FCC discussions during final review of contributions from the various working groups and portray our latest information. This report itself should be considered as dynamic, requiring periodic updating in an attempt to track rapid evolution of the computer industry relevant to requirements for magnetic fusion research. The most significant common concern among the Fusion Computing Council working groups is networking capability. All groups see an increasing need for network services due to the use of workstations, distributed computing environments, increased use of graphic services, X-window usage, remote experimental collaborations, remote data access for specific projects and other collaborations. Other areas of concern include support for workstations, enhanced infrastructure to support collaborations, the User Service Centers, NERSC and future massively parallel computers, and FCC sponsored workshops

  7. Aviation Climate Change Research Initiative (ACCRI) - An Update

    Science.gov (United States)

    Gupta, M. L.

    2009-12-01

    Aviation plays an important role in global and domestic economic development and transport mobility. There are environmental concerns associated with aviation noise and emissions. Aircraft climate impacts are primarily due to release of emissions at the cruise altitude in the upper troposphere and lower stratosphere. Even though small in magnitude at present, aviation climate impacts will likely increase with projected growth in air transport demand unless scientifically informed and balanced mitigation solutions are implemented in a timely manner. There are large uncertainties associated with global and regional non-CO2 aviation climate impacts which need to be well quantified and constrained to support decision making. To meet future aviation capacity needs, the United States is developing and implementing a dynamic, flexible and scalable Next Generation Air Transportation System (NextGen) that is safe, secure, efficient and environmentally sound. One of the stated NextGen environmental goals is to limit or reduce the impacts of aviation emissions on global climate. With the support from the participating agencies of the U.S. Climate Change Science Program, the Federal Aviation Administration (FAA) has developed Aviation Climate Change Research Initiative (ACCRI) with the main objective to identify and address key scientific gaps and uncertainties that are most likely to be achieved in near (up to 18 months) and mid (up to 36 months) term horizons while providing timely scientific input to inform decision making. Till date, ACCRI funded activities have resulted in release of 8 subject-specific whitepapers and a report on The Way Forward. These documents can be accessed via http://www.faa.gov/about/office_org/headquarters_offices/aep/aviation_climate/media/ACCRI_Report_final.pdf. This presentation will provide details on prioritized key scientific gaps and uncertainties to better characterize aviation climate impacts. This presentation will also include a brief

  8. Global foot-and-mouth disease research update and gap analysis: 6 - immunology

    Science.gov (United States)

    In 2014, the Global Foot-and-mouth disease Research Alliance (GFRA) conducted a gap analysis of FMD research. This has been updated with findings reported in a series of papers. Here we present findings for FMD immunology research. The paper consists of the following four sections: 1. Research prior...

  9. Global foot-and-mouth disease research update and gap analysis: 3 - vaccines

    Science.gov (United States)

    In 2014, the Global Foot-and-mouth disease Research Alliance (GFRA) conducted a gap analysis of FMD research. In this paper, we report updated findings in the field of FMD vaccine research. This paper consists of the following four sections: 1) Research priorities identified in the 2010 GFRA gap ana...

  10. Dementia Caregiver Burden: a Research Update and Critical Analysis.

    Science.gov (United States)

    Cheng, Sheung-Tak

    2017-08-10

    This article provides an updated review of the determinants of caregiver burden and depression, with a focus on care demands and especially the differential effects of various neuropsychiatric symptoms or symptom clusters. Moreover, studies on caregivers for frontotemporal and Lewy body dementias were referred to in order to identify differences and similarities with the mainstream literature based largely on Alzheimer caregivers. As a group, neuropsychiatric symptoms are most predictive of caregiver burden and depression regardless of dementia diagnosis, but the effects appear to be driven primarily by disruptive behaviors (e.g., agitation, aggression, disinhibition), followed by delusions and mood disturbance. Disruptive behaviors are more disturbing partly because of the adverse impact on the emotional connection between the caregiver and the care-recipient and partly because they exacerbate difficulties in other domains (e.g., caring for activities of daily living). In behavioral variant frontotemporal dementia, not only are these disruptive behaviors more prominent but they are also more disturbing due to the care-recipient's insensitivity to others' feelings. In Lewy body dementia, visual hallucinations also appear to be distressing. The disturbing nature of disruptive behaviors cuts across dementia conditions, but the roles played by symptoms that are unique or particularly serious in a certain condition need to be explored further.

  11. Nondestructive testing and evaluation of wood : a worldwide research update

    Science.gov (United States)

    Brian K. Brashaw; Voichita Bucur; Ferenc Divos; Raquel Goncalves; Jianxiong Lu; Roger Meder; Roy F. Pellerin; Simon Potter; Robert J Ross; Xiping Wang; Yafang. Yin

    2009-01-01

    The international forest products research community is responding to these driving forces by conducting NDT/NDE research to provide the technologies needed to address these challenges. This article presents a sample of the on-going NDT/NDE research efforts being conducted in several areas of the world.

  12. Global foot-and-mouth disease research update and gap analysis: 7 - pathogenesis and molecular biology

    Science.gov (United States)

    In 2014, the GFRA (Global Foot-and-mouth disease Research Alliance) conducted a gap analysis of FMD (Foot-and-Mouth Disease) research. This work has been updated and reported in a series of papers, in this article we report findings in the fields of 1) pathogenesis and 2) molecular biology. The arti...

  13. ARS irrigation research priorities and projects-An update

    Science.gov (United States)

    The USDA Agricultural Research Service focuses on six areas of research that are crucial to safe and effective use of all water resources for agricultural production: 1) Irrigation Scheduling Technologies for Water Productivity; 2) Water Productivity (WP) at Multiple Scales; 3) Irrigation Applicatio...

  14. Development of Prototype Driver Models for Highway Design: Research Update

    Science.gov (United States)

    1999-06-01

    One of the high-priority research areas of the Federal Highway Administration (FHWA) is the development of the Interactive Highway Safety Design Model (IHSDM). The goal of the IHSDM research program is to develop a systematic approach that will allow...

  15. Federal Geothermal Research Program Update Fiscal Year 1998

    Energy Technology Data Exchange (ETDEWEB)

    Keller, J.G.

    1999-05-01

    This report reviews the specific objectives, status, and accomplishments of DOE's Geothermal Research Program for Fiscal Year 1998. The Exploration Technology research area focuses on developing instruments and techniques to discover hidden hydrothermal systems and to expose the deep portions of known systems. The Reservoir Technology research combines laboratory and analytical investigations with equipment development and field testing to establish practical tools for resource development and management for both hydrothermal and hot dry rock reservoirs. The Drilling Technology projects focus on developing improved, economic drilling and completion technology for geothermal wells. The Conversion Technology research focuses on reducing costs and improving binary conversion cycle efficiency, to permit greater use of the more abundant moderate-temperature geothermal resource, and on the development of materials that will improve the operating characteristics of many types of geothermal energy equipment. Direct use research covers the direct use of geothermal energy sources for applications in other than electrical production.

  16. Low-carbohydrate diets: an update on current research.

    Science.gov (United States)

    Wylie-Rosett, Judith; Davis, Nichola J

    2009-10-01

    The diabetes and obesity epidemics have stimulated research to assess the benefits and potential risks of low-carbohydrate diets. Carbohydrate comprises less than 45% of calories in carbohydrate-restricted diets, but very low carbohydrate ketogenic diets may restrict carbohydrate to 20 g initially with variability in the carbohydrate level subsequently. Some research suggests that low-carbohydrate diets may achieve better early weight loss than comparison diets higher in carbohydrate. Studies of up to 1 year suggest that weight loss on low-carbohydrate diet is comparable with fat-restricted diets with higher carbohydrate content. Limited research has been conducted to evaluate low-carbohydrate diets in managing type 2 diabetes. Although science continues to advance in this field, current research suggests that low-carbohydrate diets can be a viable option for achieving weight loss and may have beneficial effects on glycemic control, triglyceride levels, and high-density lipoprotein cholesterol levels in some patients.

  17. Building America Research Benchmark Definition, Updated December 19, 2008

    Energy Technology Data Exchange (ETDEWEB)

    Hendron, R. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2008-12-19

    To track progress toward aggressive multi-year whole-house energy savings goals of 40-70% and onsite power production of up to 30%, DOE's Residential Buildings Program and NREL developed the Building America Research Benchmark in consultation with the Bui

  18. Building America Research Benchmark Definition: Updated December 19, 2008

    Energy Technology Data Exchange (ETDEWEB)

    Hendron, R.

    2008-12-01

    To track progress toward aggressive multi-year whole-house energy savings goals of 40-70% and onsite power production of up to 30%, DOE's Residential Buildings Program and NREL developed the Building America Research Benchmark in consultation with the Building America industry teams.

  19. Building America Research Benchmark Definition, Updated December 2009

    Energy Technology Data Exchange (ETDEWEB)

    Hendron, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States); Engebrecht, Cheryn [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2010-01-01

    To track progress toward aggressive multi-year, whole-house energy savings goals of 40%–70% and on-site power production of up to 30%, the U.S. Department of Energy (DOE) Residential Buildings Program and the National Renewable Energy Laboratory (NREL) developed the Building America (BA) Research Benchmark in consultation with the Building America industry teams.

  20. Research Update: Enhancing the Youth Sports Experience through Coaching.

    Science.gov (United States)

    Steelman, Todd

    1995-01-01

    Reviews research on the relationship between youth sports coaches and players, noting that the youth sports coach can be the most important figure in socializing children in the area of sports. The paper discusses how to deal with the stresses in coaching and examines the need for coach effectiveness training. (SM)

  1. Results from oil spill response research - an update

    International Nuclear Information System (INIS)

    Tennyson, E.J.

    1993-01-01

    Recent large oil spills from tankers have reaffirmed the need for continuing technology assessment and research to improve oil spill response capabilities. This paper discusses Minerals Management Service concerns, as reinforced by the acceleration of its research program in 1990. It briefly assesses current state-of-the-art technology for major aspects of spill response, including remote sensing, open-ocean containment and recovery, in-situ burning, use of chemical treating agents, beachline cleanup, and oil behavior. Specific research projects have begun to yield information that will improve detection and at-sea equipment performance; current projects include the development of an airborne laser-fluorosensor to determine whether apparent slicks contain oil. Additional projects involve the development of improved strategies for responding to oil in broken-ice conditions, for gaining an improved understanding of the fate and behavior of spilled oil as it affects response strategies, and for defining the capabilities of available dispersants and development of improved formulations. Recently, progress has been made on the development of safe and environmentally acceptable strategies to burn spilled oil in situ. The Ohmsett facility has been reopened and will be used to test prospective improvements in chemical treating agents and to develop standard procedures for testing and evaluating response equipment. Results of research published since the last Oil Spill Conference are discussed

  2. Choke in orchardgrass: research update and potential control

    Science.gov (United States)

    Choke, caused by the endophytic fungus Epichloe typhina is a serious and persistent problem in orchardgrass seed production fields. Recent research on choke has provided new insight into the biology and epidemiology of E. typhina. Fungicides for prevention of infection have not proven effective. How...

  3. DNA Damage Repair System in Plants: A Worldwide Research Update.

    Science.gov (United States)

    Gimenez, Estela; Manzano-Agugliaro, Francisco

    2017-10-30

    Living organisms are usually exposed to various DNA damaging agents so the mechanisms to detect and repair diverse DNA lesions have developed in all organisms with the result of maintaining genome integrity. Defects in DNA repair machinery contribute to cancer, certain diseases, and aging. Therefore, conserving the genomic sequence in organisms is key for the perpetuation of life. The machinery of DNA damage repair (DDR) in prokaryotes and eukaryotes is similar. Plants also share mechanisms for DNA repair with animals, although they differ in other important details. Plants have, surprisingly, been less investigated than other living organisms in this context, despite the fact that numerous lethal mutations in animals are viable in plants. In this manuscript, a worldwide bibliometric analysis of DDR systems and DDR research in plants was made. A comparison between both subjects was accomplished. The bibliometric analyses prove that the first study about DDR systems in plants (1987) was published thirteen years later than that for other living organisms (1975). Despite the increase in the number of papers about DDR mechanisms in plants in recent decades, nowadays the number of articles published each year about DDR systems in plants only represents 10% of the total number of articles about DDR. The DDR research field was done by 74 countries while the number of countries involved in the DDR & Plant field is 44. This indicates the great influence that DDR research in the plant field currently has, worldwide. As expected, the percentage of studies published about DDR systems in plants has increased in the subject area of agricultural and biological sciences and has diminished in medicine with respect to DDR studies in other living organisms. In short, bibliometric results highlight the current interest in DDR research in plants among DDR studies and can open new perspectives in the research field of DNA damage repair.

  4. Minority University Research and Education Division (MURED) Update

    Science.gov (United States)

    Malone, John

    2000-01-01

    Program priorities include: (1) Expand and advance NASA's scientific and technological base by building on prior year's efforts in research and academic infrastructure; (2) Increase exposure to NASA's unique mission and facilities by developing closer relationships with NASA Strategic Enterprises; (3) Increase involvement in competitive peer review and merit selection processes; (4) Contribute significantly to the Agency's strategic goals and objectives; (5) Create systemic and sustainable change through partnerships and programs that enhance research and education programs; (6) Prepare faculty and students at HBCU's for NASA-related fields and increase number of students that enter and successfully complete degrees in NASA-related fields; (7) Establish measurable program goals and objectives; and (8) Improve financial management performance.

  5. Research in Osteochondritis Dissecans of the Knee: 2016 Update.

    Science.gov (United States)

    Nepple, Jeffrey J; Milewski, Matthew D; Shea, Kevin G

    2016-10-01

    Osteochondritis dissecans (OCD) of the knee remains a relatively common and poorly understood pediatric and adolescent knee condition. Both conservative and surgical treatments have major impact on the lives of young active, athletic patients with knee OCD. OCD has been recently redefined as a "focal, idiopathic alteration of subchondral bone with risk for instability and disruption of adjacent articular cartilage that may result in premature osteoarthritis." The 2011 American Academy of Orthopedic Surgeons Clinical Practice Guidelines found limited evidence for all aspects of the treatment of knee OCD. The multicenter study group Research in Osteochondritis dissecans of the Knee (ROCK) was formed to advance the understanding and treatment of this condition. This article will review our current understanding of the pathophysiology, treatment options, and outcomes of OCD of the knee, with a focus on the past, present, and future research including the work of the ROCK study group. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  6. UNENE: an update on nuclear education and research

    International Nuclear Information System (INIS)

    Shalaby, B.A.; Snell, V.G.; Rouben, B.

    2011-01-01

    University Network for Excellence in Nuclear Engineering (known as UNENE) was created in 2002 as a partnership between Industry and universities with the objectives of establishing a nuclear R and D program in universities to train and develop Highly Qualified Personnel (HQP) to address the demographic gap and to create a sustainable source of expertise for independent industry and public consultation. Seven years into its creation, UNENE is now a well established and fully functional framework with programs mainly focussing on education and research serving the industry at large. The educational component is in the form of an M. Eng program mainly catering for working profession's by being offered on weekends and using distance learning tools. It is intended to enhance competencies and build knowledge for students. The R and D programs are lead by Industrial Research chairs (IRCs) and other prominent researchers in areas of importance to the industry. This paper examines the above topics and its outcomes as of March 2010. (author)

  7. Update in research and methods in proteomics and bioinformatics.

    Science.gov (United States)

    Bencharit, Sompop; Border, Michael B; Edelmann, Alex; Byrd, Warren C

    2013-10-01

    The 3rd International Conference on Proteomics & Bioinformatics (Proteomics 2013) Philadelphia, PA, USA, 15-17 July 2013 The Third International Conference on Proteomics & Bioinformatics (Proteomics 2013) was sponsored by the OMICS group and was organized in order to strengthen the future of proteomics science by bringing together professionals, researchers and scholars from leading universities across the globe. The main topics of this conference included the integration of novel platforms in data analysis, the use of a systems biology approach, different novel mass spectrometry platforms and biomarker discovery methods. The conference was divided into proteomic methods and research interests. Among these two categories, interactions between methods in proteomics and bioinformatics, as well as other research methodologies, were discussed. Exceptional topics from the keynote forum, oral presentations and the poster session have been highlighted. The topics range from new techniques for analyzing proteomics data, to new models designed to help better understand genetic variations to the differences in the salivary proteomes of HIV-infected patients.

  8. Wind Energy in the United States: Market and Research Update

    International Nuclear Information System (INIS)

    Goldman, P.R.; Thresher, R.W.; Hock, S.M.

    1999-01-01

    U.S. market activity has increased over the last two years. In 1998, new capacity totaled about 150 MW and projected 1999 capacity additions are over 600 MW. As the electricity market continues to evolve under restructuring, the U.S. Department of Energy (U.S. DOE) Wind Energy Program has positioned itself to work with industry to meet current challenges and opportunities, and prepare for the market of tomorrow. Some opportunities include green power markets and distributed applications, although a primary challenge involves the fact that avoided cost payments to renewable generators are not high enough to economically support projects. A recently incorporated power exchange in California, APX, Inc., has demonstrated that green power does attract a premium over prices on the conventional power exchange. The key elements of the U.S. DOE Wind Program are (1) Applied Research, which is critical for achieving advanced turbine designs capable of competing in a restructured market that emphasizes low cost generation; (2) Turbine Research, which supports the U.S. industry in developing competitive, high performance, reliable wind turbine technology for global energy markets; and (3) Cooperative Research and Testing, under which standards development and certification testing are the key activities for the current year

  9. The 2016 database issue of Nucleic Acids Research and an updated molecular biology database collection

    Science.gov (United States)

    Rigden, Daniel J.; Fernández-Suárez, Xosé M.; Galperin, Michael Y.

    2016-01-01

    The 2016 Database Issue of Nucleic Acids Research starts with overviews of the resources provided by three major bioinformatics centers, the U.S. National Center for Biotechnology Information (NCBI), the European Bioinformatics Institute (EMBL-EBI) and Swiss Institute for Bioinformatics (SIB). Also included are descriptions of 62 new databases and updates on 95 databases that have been previously featured in NAR plus 17 previously described elsewhere. A number of papers in this issue deal with resources on nucleic acids, including various kinds of non-coding RNAs and their interactions, molecular dynamics simulations of nucleic acid structure, and two databases of super-enhancers. The protein database section features important updates on the EBI's Pfam, PDBe and PRIDE databases, as well as a variety of resources on pathways, metabolomics and metabolic modeling. This issue also includes updates on popular metagenomics resources, such as MG-RAST, EBI Metagenomics, and probeBASE, as well as a newly compiled Human Pan-Microbe Communities database. A significant fraction of the new and updated databases are dedicated to the genetic basis of disease, primarily cancer, and various aspects of drug research, including resources for patented drugs, their side effects, withdrawn drugs, and potential drug targets. A further six papers present updated databases of various antimicrobial and anticancer peptides. The entire Database Issue is freely available online on the Nucleic Acids Research website (http://nar.oxfordjournals.org/). The NAR online Molecular Biology Database Collection, http://www.oxfordjournals.org/nar/database/c/, has been updated with the addition of 88 new resources and removal of 23 obsolete websites, which brought the current listing to 1685 databases. PMID:26740669

  10. Quality of Life in Individuals with Spina Bifida: A Research Update

    Science.gov (United States)

    Sawin, Kathleen J.; Bellin, Melissa H.

    2010-01-01

    Quality of life (QOL) is an important concept for individuals with chronic health conditions. Measuring and supporting QOL in children, adolescents, and adults with spina bifida (SB) may be especially unique given the broad range of complex health and rehabilitative challenges they encounter. This article provides a research update on (a)…

  11. A Dialogic about Using Facebook Status Updates for Education Research: A PhD Student's Journey

    Science.gov (United States)

    Barnes, Naomi; Penn-Edwards, Sorrel; Sim, Cheryl

    2015-01-01

    Facebook status updates provided the data for a study about the transition learning experiences of 1st-year university students. Strict ethical guidelines were proposed by the PhD researcher from the outset of the study. Anonymity was considered important for the approved ethical clearance for both the university and the participants.…

  12. An updated method for risk adjustment in outcomes research.

    Science.gov (United States)

    Doi, Suhail A R; Barendregt, Jan J; Rao, Chalapati

    2014-07-01

    To demonstrate why meta-analytic methods need modification before they can be used to aggregate rates or effect sizes in outcomes research, under the constraint of no common underlying effect or rate. Studies are presented that require different types of risk adjustment. First, we demonstrate using rates that external risk adjustment through standardization can be achieved using modified meta-analytic methods, but only with a model that allows input of user-defined weights. Next, we extend these observations to internal risk adjustment of comparative effect sizes. We show that this procedure produces identical results to conventional age standardization if a rate is being standardized for age. We also demonstrate that risk adjustment of effect sizes can be achieved with this modified method but cannot be done using standard meta-analysis. We conclude that this method allows risk adjustment to be performed in situations in which currently the fixed- or random-effects methods of meta-analysis are inappropriately used. The latter should be avoided when the underlying aim is risk adjustment rather than meta-analysis. Copyright © 2014 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  13. Building America Research Benchmark Definition: Updated December 20, 2007

    Energy Technology Data Exchange (ETDEWEB)

    Hendron, R.

    2008-01-01

    To track progress toward aggressive multi-year whole-house energy savings goals of 40-70% and onsite power production of up to 30%, DOE's Residential Buildings Program and NREL developed the Building America Research Benchmark in consultation with the Building America industry teams. The Benchmark is generally consistent with mid-1990s standard practice, as reflected in the Home Energy Rating System (HERS) Technical Guidelines (RESNET 2002), with additional definitions that allow the analyst to evaluate all residential end-uses, an extension of the traditional HERS rating approach that focuses on space conditioning and hot water. Unlike the reference homes used for HERS, EnergyStar, and most energy codes, the Benchmark represents typical construction at a fixed point in time so it can be used as the basis for Building America's multi-year energy savings goals without the complication of chasing a 'moving target'.

  14. Building America Research Benchmark Definition, Updated December 29, 2004

    Energy Technology Data Exchange (ETDEWEB)

    Hendron, R.

    2005-02-01

    To track progress toward aggressive multi-year whole-house energy savings goals of 40-70% and onsite power production of up to 30%, the U.S. Department of Energy (DOE) Residential Buildings Program and the National Renewable Energy Laboratory (NREL) developed the Building America Research Benchmark in consultation with the Building America industry teams. The Benchmark is generally consistent with mid-1990s standard practice, as reflected in the Home Energy Rating System (HERS) Technical Guidelines (RESNET 2002), with additional definitions that allow the analyst to evaluate all residential end-uses, an extension of the traditional HERS rating approach that focuses on space conditioning and hot water. A series of user profiles, intended to represent the behavior of a ''standard'' set of occupants, was created for use in conjunction with the Benchmark.

  15. Building America Research Benchmark Definition, Updated December 15, 2006

    Energy Technology Data Exchange (ETDEWEB)

    Hendron, R.

    2007-01-01

    To track progress toward aggressive multi-year whole-house energy savings goals of 40-70% and onsite power production of up to 30%, DOE's Residential Buildings Program and NREL developed the Building America Research Benchmark in consultation with the Building America industry teams. The Benchmark is generally consistent with mid-1990s standard practice, as reflected in the Home Energy Rating System (HERS) Technical Guidelines (RESNET 2002), with additional definitions that allow the analyst to evaluate all residential end-uses, an extension of the traditional HERS rating approach that focuses on space conditioning and hot water. Unlike the reference homes used for HERS, EnergyStar, and most energy codes, the Benchmark represents typical construction at a fixed point in time so it can be used as the basis for Building America's multi-year energy savings goals without the complication of chasing a ''moving target''.

  16. Building America Research Benchmark Definition: Updated August 15, 2007

    Energy Technology Data Exchange (ETDEWEB)

    Hendron, R.

    2007-09-01

    To track progress toward aggressive multi-year whole-house energy savings goals of 40-70% and onsite power production of up to 30%, DOE's Residential Buildings Program and NREL developed the Building America Research Benchmark in consultation with the Building America industry teams. The Benchmark is generally consistent with mid-1990s standard practice, as reflected in the Home Energy Rating System (HERS) Technical Guidelines (RESNET 2002), with additional definitions that allow the analyst to evaluate all residential end-uses, an extension of the traditional HERS rating approach that focuses on space conditioning and hot water. Unlike the reference homes used for HERS, EnergyStar, and most energy codes, the Benchmark represents typical construction at a fixed point in time so it can be used as the basis for Building America's multi-year energy savings goals without the complication of chasing a 'moving target'.

  17. Current Pharmacologic Approaches in Painful Bladder Research: An Update

    Science.gov (United States)

    2017-01-01

    The symptoms of interstitial cystitis (IC)/bladder pain syndrome (BPS) may have multiple causes and involve many contributing factors. Traditional treatments (intravesical instillations) have had a primary focus on the bladder as origin of symptoms without adequately considering the potential influence of other local (pelvic) or systemic factors. Systemic pharmacological treatments have had modest success. A contributing factor to the low efficacy is the lack of phenotyping the patients. Individualized treatment based on is desirable, but further phenotype categorization is needed. There seems to be general agreement that IC is a unique disease and that BPS is a syndrome with multiple pathophysiologies, but this has so far not been not been well reflected in preclinical research with the aim of finding new pharmacological treatments. Current research approaches, including anti-nerve growth factor treatment, anti-tumor necrosis factor-α treatment, activation of SHIP1 (AQX-1125), and P2X3 receptor antagonists, and α1-adrenoceptor antagonists are potential systemic treatments, implying that not only the bladder is exposed to the administered drug, which may be beneficial if the IC/BPS is a bladder manifestation of a systemic disease, or negative (adverse effects) if it is a local bladder condition. Local treatment approaches such as the antagonism of Toll-like receptors (which still is only experimental) and intravesical liposomes (with positive proof-of-concept), may have the advantages of a low number of systemic adverse effects, but cannot be expected to have effects on symptoms generated outside the bladder. Assessment of which of the treatment approaches discussed in this review that can be developed into useful therapies requires further studies. PMID:29298474

  18. Federal Geothermal Research Program Update - Fiscal Year 2004

    Energy Technology Data Exchange (ETDEWEB)

    Patrick Laney

    2005-03-01

    The Department of Energy (DOE) and its predecessors have conducted research and development (R&D) in geothermal energy since 1971. The Geothermal Technologies Program (GTP) works in partnership with industry to establish geothermal energy as an economically competitive contributor to the U.S. energy supply. Geothermal energy production, a $1.5 billion a year industry, generates electricity or provides heat for direct use applications. The technologies developed by the Geothermal Technologies Program will provide the Nation with new sources of electricity that are highly reliable and cost competitive and do not add to America's air pollution or the emission of greenhouse gases. Geothermal electricity generation is not subject to fuel price volatility and supply disruptions from changes in global energy markets. Geothermal energy systems use a domestic and renewable source of energy. The Geothermal Technologies Program develops innovative technologies to find, access, and use the Nation's geothermal resources. These efforts include emphasis on Enhanced Geothermal Systems (EGS) with continued R&D on geophysical and geochemical exploration technologies, improved drilling systems, and more efficient heat exchangers and condensers. The Geothermal Technologies Program is balanced between short-term goals of greater interest to industry, and long-term goals of importance to national energy interests. The program's research and development activities are expected to increase the number of new domestic geothermal fields, increase the success rate of geothermal well drilling, and reduce the costs of constructing and operating geothermal power plants. These improvements will increase the quantity of economically viable geothermal resources, leading in turn to an increased number of geothermal power facilities serving more energy demand. These new geothermal projects will take advantage of geothermal resources in locations where development is not currently possible or

  19. Federal Geothermal Research Program Update Fiscal Year 2004

    Energy Technology Data Exchange (ETDEWEB)

    2005-03-01

    The Department of Energy (DOE) and its predecessors have conducted research and development (R&D) in geothermal energy since 1971. The Geothermal Technologies Program (GTP) works in partnership with industry to establish geothermal energy as an economically competitive contributor to the U.S. energy supply. Geothermal energy production, a $1.5 billion a year industry, generates electricity or provides heat for direct use applications. The technologies developed by the Geothermal Technologies Program will provide the Nation with new sources of electricity that are highly reliable and cost competitive and do not add to America's air pollution or the emission of greenhouse gases. Geothermal electricity generation is not subject to fuel price volatility and supply disruptions from changes in global energy markets. Geothermal energy systems use a domestic and renewable source of energy. The Geothermal Technologies Program develops innovative technologies to find, access, and use the Nation's geothermal resources. These efforts include emphasis on Enhanced Geothermal Systems (EGS) with continued R&D on geophysical and geochemical exploration technologies, improved drilling systems, and more efficient heat exchangers and condensers. The Geothermal Technologies Program is balanced between short-term goals of greater interest to industry, and long-term goals of importance to national energy interests. The program's research and development activities are expected to increase the number of new domestic geothermal fields, increase the success rate of geothermal well drilling, and reduce the costs of constructing and operating geothermal power plants. These improvements will increase the quantity of economically viable geothermal resources, leading in turn to an increased number of geothermal power facilities serving more energy demand. These new geothermal projects will take advantage of geothermal resources in locations where development is not currently

  20. Significant events in psychotherapy: An update of research findings.

    Science.gov (United States)

    Timulak, Ladislav

    2010-11-01

    Significant events research represents a specific approach to studying client-identified important moments in the therapy process. The current study provides an overview of the significant events research conducted, the methodology used together with findings and implications. PsychInfo database was searched with keywords such as significant events, important events, significant moments, important moments, and counselling or psychotherapy. The references of the selected studies were also searched. This process led to the identification of 41 primary studies that used client-identified significant event(s) as a main or secondary focus of the study. These were consequently reviewed with regard to their methodology and findings. The findings are presented according to type of study conducted. The impacts of helpful events reported by clients are focused on contributions to therapeutic relationship and to in-session outcomes. Hindering events focus on some client disappointment with the therapist or therapy. The group therapy modality highlighted additional helpful impacts (like learning from others). Perspectives on what is significant in therapy differ between clients and therapists. The intensive qualitative studies reviewed confirm that the processes involved in significant events are complex and ambiguous. Studies show that the helpful events may also contain many hindering elements and that specific events are deeply contextually embedded in the preceding events of therapy. Some studies suggest that helpful significant events are therapeutically productive although this may need to be established further. Specific intensive studies show that the clients' perceptions in therapy may differ dramatically from that of the therapist. Furthermore, the relational and emotional aspects of significant moments may be more important for the clients than the cognitive aspects of therapy which are frequently stressed by therapists. 2010 The British Psychological Society.

  1. Research Update: Electrical monitoring of cysts using organic electrochemical transistors

    International Nuclear Information System (INIS)

    Huerta, M.; Rivnay, J.; Ramuz, M.; Hama, A.; Owens, R. M.

    2015-01-01

    Organotypic three-dimensional (3D) cell culture models have the potential to act as surrogate tissues in vitro, both for basic research and for drug discovery/toxicology. 3D cultures maintain not only 3D architecture but also cell-cell and cell extracellular matrix interactions, particularly when grown in cysts or spheroids. Characterization of cell cultures grown in 3D formats, however, provides a significant challenge for cell biologists due to the incompatibility of these structures with commonly found optical or electronic monitoring systems. Electronic impedance spectroscopy is a cell culture monitoring technique with great potential; however, it has not been possible to integrate 3D cultures with commercially available systems to date. Cyst-like 3D cultures are particularly challenging due to their small size and difficulty in manipulation. Herein, we demonstrate isolation of cyst-like 3D cultures by capillarity and subsequent integration with the organic electrochemical transistor for monitoring the integrity of these structures. We show not only that this versatile device can be adapted to the cyst format for measuring resistance and, therefore, the quality of the cysts, but also can be used for quantitative monitoring of the effect of toxic compounds on cells in a 3D format. The ability to quantitatively predict effects of drugs on 3D cultures in vitro has large future potential for the fields of drug discovery and toxicology

  2. Current practices and research updates on diabetes mellitus in canine

    Directory of Open Access Journals (Sweden)

    Pankaj Kumar

    2014-11-01

    Full Text Available Diabetes has evidence in ancient literatures, though recently is being considered as one amongst the most emerging disease condition in both human and companion animals. Diabetes mellitus is one of the common endocrinopathy of dog characterized by hyperglycemia, glycosuria and weight loss. Reports suggests high fraction of canine population suffer with diabetes world over. Studies in different veterinary hospitals of United States suggest increase in cases of canine diabetes and decrease in case fatality rate over time. Increase in cases of canine diabetes worldwide is attributed to awareness amongst pet owners, better veterinary health facilities, breed preferences by dog owners, increase dependence on commercial feeds, obesity, etc. Diabetes in most dogs is immune mediated and insulin dependent. Breed predisposition in canine is attributed to dog leukocyte antigen gene pool encoding form major histocompatibility complex-II molecules, however research is still underway. Diagnosis of diabetes still relies on blood sugar evaluation for screening of canine population, though many other diagnostic methods have shown promising benefits including measurement of fructosamine and glycated haemoglobin. Management of diabetes in dog is based on insulin therapy, diet modification and exercise. Use of oral anti-diabetics drugs in canine is limited though experimental studies have shown promising results. Alternative therapies have been explored, but only a few approaches have shown promise for clinical application.

  3. The 2014 Nucleic Acids Research Database Issue and an updated NAR online Molecular Biology Database Collection.

    Science.gov (United States)

    Fernández-Suárez, Xosé M; Rigden, Daniel J; Galperin, Michael Y

    2014-01-01

    The 2014 Nucleic Acids Research Database Issue includes descriptions of 58 new molecular biology databases and recent updates to 123 databases previously featured in NAR or other journals. For convenience, the issue is now divided into eight sections that reflect major subject categories. Among the highlights of this issue are six databases of the transcription factor binding sites in various organisms and updates on such popular databases as CAZy, Database of Genomic Variants (DGV), dbGaP, DrugBank, KEGG, miRBase, Pfam, Reactome, SEED, TCDB and UniProt. There is a strong block of structural databases, which includes, among others, the new RNA Bricks database, updates on PDBe, PDBsum, ArchDB, Gene3D, ModBase, Nucleic Acid Database and the recently revived iPfam database. An update on the NCBI's MMDB describes VAST+, an improved tool for protein structure comparison. Two articles highlight the development of the Structural Classification of Proteins (SCOP) database: one describes SCOPe, which automates assignment of new structures to the existing SCOP hierarchy; the other one describes the first version of SCOP2, with its more flexible approach to classifying protein structures. This issue also includes a collection of articles on bacterial taxonomy and metagenomics, which includes updates on the List of Prokaryotic Names with Standing in Nomenclature (LPSN), Ribosomal Database Project (RDP), the Silva/LTP project and several new metagenomics resources. The NAR online Molecular Biology Database Collection, http://www.oxfordjournals.org/nar/database/c/, has been expanded to 1552 databases. The entire Database Issue is freely available online on the Nucleic Acids Research website (http://nar.oxfordjournals.org/).

  4. Updating to the WAIS-III and WMS-III: considerations for research and clinical practice.

    Science.gov (United States)

    Tulsky, David S; Ledbetter, Mark F

    2000-09-01

    The Wechsler Adult Intelligence Scale-Revised (WAIS-R) and the Wechsler Memory Scale-Revised (WMS-R) are the most commonly used intelligence and memory scales in both clinical and neuropsychology. In 1997, updated versions of these instruments (the WAIS-III and WMS-III) were published. Because of the extensive use of the WAIS-R and WMS-R in the field and the body of accumulated research, there is naturally some reluctance by clinicians and researchers to update to the new versions. It is sometimes difficult for clinicians who test individuals on repeated occasions to switch over to the new versions of the scales because of the difficulty of interpreting score discrepancy between the 2 versions. Researchers, especially those conducting longitudinal research, have a similar difficulty in changing measurement devices because of the possible threat of internal validity. This article reviews the substantive revisions of the scales and outlines those issues that users should take into consideration when updating to the new versions.

  5. The U.S. Geological Survey Amphibian Research and Monitoring Initiative-2011 Annual Update

    Science.gov (United States)

    Adams, M.J.; Muths, E.; Grant, E.H.C.; Miller, David A.; Waddle, J.H.; Ball, L.C.

    2012-01-01

    Welcome to the inaugural issue of ARMI's Annual Update. This update provides highlights and significant milestones of this innovative program. ARMI is uniquely qualified to provide research and monitoring results that are scalable from local to national levels, and are useful to resource managers. ARMI has produced nearly 400 peer-reviewed publications, including 18 in 2011. Some of those publications are highlighted in this fact sheet. ARMI also has a new Website (armi.usgs.gov). You can now use it to explore an up-to-date list of ARMI products, to find summaries of research topics, to search for ARMI activities in your area, and to obtain amphibian photographs. ARMI's annual meeting was organized by Walt Sadinski, Upper Midwest Environmental Science Center, and held in St Louis, Missouri. We met with local scientists and managers in herpetology and were given a tour of the herpetology collection at the St. Louis Zoo.

  6. New York State Energy Research and Development Authority. Research projects` update project status as of March 31, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    This report provides an update of the New York State Energy Research and Development Authority (NYSERDA) program. The NYSERDA research and development program has five major areas: industry, buildings, energy resources, transportation, and environment. NYSERDA organizes projects within these five major areas based on energy use and supply, and end-use sectors. Therefore, issues such as waste management, energy products and renewable energy technologies are addressed in several areas of the program. The project descriptions presented are organized within the five program areas. Descriptions of projects completed between the period April 1, 1996, and March 31, 1997, including technology-transfer activities, are at the end of each subprogram section.

  7. Research Update: Programmable tandem repeat proteins inspired by squid ring teeth

    Science.gov (United States)

    Pena-Francesch, Abdon; Domeradzka, Natalia E.; Jung, Huihun; Barbu, Benjamin; Vural, Mert; Kikuchi, Yusuke; Allen, Benjamin D.; Demirel, Melik C.

    2018-01-01

    Cephalopods have evolved many interesting features that can serve as inspiration. Repetitive squid ring teeth (SRT) proteins from cephalopods exhibit properties such as strength, self-healing, and biocompatibility. These proteins have been engineered to design novel adhesives, self-healing textiles, and the assembly of 2d-layered materials. Compared to conventional polymers, repetitive proteins are easy to modify and can assemble in various morphologies and molecular architectures. This research update discusses the molecular biology and materials science of polypeptides inspired by SRT proteins, their properties, and perspectives for future applications.

  8. GSD Update: Year in Review: Spotlight on 2013 research by the Grassland, Shrubland and Desert Ecosystems Science Program

    Science.gov (United States)

    Deborah M. Finch

    2014-01-01

    In this issue of the GSD Update, we take a look back at selected studies of the Grassland, Shrubland and Desert Ecosystems Science Program (GSD) that depict its strengths and focus areas. Significant results of recent research and science delivery by GSD scientists are highlighted. We feature program research that lines up with the strategic research priorities of the...

  9. GSD Update: Year in Review: Spotlight on 2015 Research by the Grassland, Shrubland and Desert Ecosystems Science Program

    Science.gov (United States)

    Deborah. Finch

    2016-01-01

    In this issue of the GSD Update, we take a look back at selected studies of the Grassland, Shrubland and Desert Ecosystems Science Program (GSD) that depict its strengths and focus areas. Significant results of recent research and science delivery by GSD scientists are highlighted. We feature program research that lines up with the strategic research...

  10. The National Shipbuilding Research Program. United States Shipbuilding Standards Master Plan Update

    National Research Council Canada - National Science Library

    1997-01-01

    .... 7. Develop a marketing strategy for the plan. 8. Adopt or convert existing global standards for domestic use. This update includes an updated survey, the SP-6 tactical plan, new windows into standards on the internet, and more.

  11. Research Update: The electronic structure of hybrid perovskite layers and their energetic alignment in devices

    Directory of Open Access Journals (Sweden)

    Selina Olthof

    2016-09-01

    Full Text Available In recent years, the interest in hybrid organic–inorganic perovskites has increased at a rapid pace due to their tremendous success in the field of thin film solar cells. This area closely ties together fundamental solid state research and device application, as it is necessary to understand the basic material properties to optimize the performances and open up new areas of application. In this regard, the energy levels and their respective alignment with adjacent charge transport layers play a crucial role. Currently, we are lacking a detailed understanding about the electronic structure and are struggling to understand what influences the alignment, how it varies, or how it can be intentionally modified. This research update aims at giving an overview over recent results regarding measurements of the electronic structure of hybrid perovskites using photoelectron spectroscopy to summarize the present status.

  12. The OMERACT MRI in Arthritis Working Group - Update on Status and Future Research Priorities

    DEFF Research Database (Denmark)

    Østergaard, Mikkel; Bird, Paul; Gandjbakhch, Frédérique

    2015-01-01

    OBJECTIVE: To provide an update on the status and future research priorities of the Outcome Measures in Rheumatology (OMERACT) magnetic resonance imaging (MRI) in arthritis working group. METHODS: A summary is provided of the activities of the group within rheumatoid arthritis (RA), psoriatic......, and at the OMERACT 12 conference, we provided longitudinal data demonstrating reliability and sensitivity to change of the RAMRIS JSN component score, supporting its use in future clinical trials. The MRI group has previously developed a PsA MRI score (PsAMRIS). At OMERACT 12, PsAMRIS was evaluated in a randomized...... reliability, but variable reliability of change scores, were reported. Potential future research areas were identified at the MRI session at OMERACT 12 including assessment of tenosynovitis in RA and enthesitis in PsA and focusing on alternative MRI techniques. CONCLUSION: MRI has been further developed...

  13. Individual determinants of research utilization by nurses: a systematic review update

    Science.gov (United States)

    2011-01-01

    Background Interventions that have a better than random chance of increasing nurses' use of research are important to the delivery of quality patient care. However, few reports exist of successful research utilization in nursing interventions. Systematic identification and evaluation of individual characteristics associated with and predicting research utilization may inform the development of research utilization interventions. Objective To update the evidence published in a previous systematic review on individual characteristics influencing research utilization by nurses. Methods As part of a larger systematic review on research utilization instruments, 12 online bibliographic databases were searched. Hand searching of specialized journals and an ancestry search was also conducted. Randomized controlled trials, clinical trials, and observational study designs examining the association between individual characteristics and nurses' use of research were eligible for inclusion. Studies were limited to those published in the English, Danish, Swedish, and Norwegian languages. A vote counting approach to data synthesis was taken. Results A total of 42,770 titles were identified, of which 501 were retrieved. Of these 501 articles, 45 satisfied our inclusion criteria. Articles assessed research utilization in general (n = 39) or kinds of research utilization (n = 6) using self-report survey measures. Individual nurse characteristics were classified according to six categories: beliefs and attitudes, involvement in research activities, information seeking, education, professional characteristics, and socio-demographic/socio-economic characteristics. A seventh category, critical thinking, emerged in studies examining kinds of research utilization. Positive relationships, at statistically significant levels, for general research utilization were found in four categories: beliefs and attitudes, information seeking, education, and professional characteristics. The only

  14. Individual determinants of research utilization by nurses: a systematic review update

    Directory of Open Access Journals (Sweden)

    Wallin Lars

    2011-01-01

    Full Text Available Abstract Background Interventions that have a better than random chance of increasing nurses' use of research are important to the delivery of quality patient care. However, few reports exist of successful research utilization in nursing interventions. Systematic identification and evaluation of individual characteristics associated with and predicting research utilization may inform the development of research utilization interventions. Objective To update the evidence published in a previous systematic review on individual characteristics influencing research utilization by nurses. Methods As part of a larger systematic review on research utilization instruments, 12 online bibliographic databases were searched. Hand searching of specialized journals and an ancestry search was also conducted. Randomized controlled trials, clinical trials, and observational study designs examining the association between individual characteristics and nurses' use of research were eligible for inclusion. Studies were limited to those published in the English, Danish, Swedish, and Norwegian languages. A vote counting approach to data synthesis was taken. Results A total of 42,770 titles were identified, of which 501 were retrieved. Of these 501 articles, 45 satisfied our inclusion criteria. Articles assessed research utilization in general (n = 39 or kinds of research utilization (n = 6 using self-report survey measures. Individual nurse characteristics were classified according to six categories: beliefs and attitudes, involvement in research activities, information seeking, education, professional characteristics, and socio-demographic/socio-economic characteristics. A seventh category, critical thinking, emerged in studies examining kinds of research utilization. Positive relationships, at statistically significant levels, for general research utilization were found in four categories: beliefs and attitudes, information seeking, education, and professional

  15. Sulfur technology update: selected research topics from the ASRL core research program

    Energy Technology Data Exchange (ETDEWEB)

    Clark, P. D.; Dowling, N. I.; Marriott, R.A.; Primak, A.; Davis, P.M. [Alberta Sulphur Research Ltd (Canada)

    2011-07-01

    This conference presentation is a combined effort by Alberta Sulfur Research, Ltd (ASRL) and the University of Calgary; it focuses on sulfur production technology and the ongoing research behind it. This presentation deals mainly with the use of sulfur in the oil sand industry, sulfur recovery in Claus systems, and sulfur management issues. Sulfur formation, mainly in the form of hydrogen sulfide, and the use of liquid sulfur in bitumen coking in the petrochemical industries were discussed first. This was later followed by an illustration of how sulfur recovery efficiency is greatly enhanced by catalytic tail gas incineration and improved liquid sulfur degassing technologies. A comparative scheme between the current process and the new research in utilizing sulfur in nickel metal production was also presented, showing how the new research results in less waste. In conclusion, the effects of polymeric sulfur on the strength of the solid were discussed, showing a linear relationship between the two parameters.

  16. The Oral HIV/AIDS Research Alliance: updated case definitions of oral disease endpoints.

    Science.gov (United States)

    Shiboski, C H; Patton, L L; Webster-Cyriaque, J Y; Greenspan, D; Traboulsi, R S; Ghannoum, M; Jurevic, R; Phelan, J A; Reznik, D; Greenspan, J S

    2009-07-01

    The Oral HIV/AIDS Research Alliance (OHARA) is part of the AIDS Clinical Trials Group (ACTG), the largest HIV clinical trials organization in the world. Its main objective is to investigate oral complications associated with HIV/AIDS as the epidemic is evolving, in particular, the effects of antiretrovirals on oral mucosal lesion development and associated fungal and viral pathogens. The OHARA infrastructure comprises: the Epidemiologic Research Unit (at the University of California San Francisco), the Medical Mycology Unit (at Case Western Reserve University) and the Virology/Specimen Banking Unit (at the University of North Carolina). The team includes dentists, physicians, virologists, mycologists, immunologists, epidemiologists and statisticians. Observational studies and clinical trials are being implemented at ACTG-affiliated sites in the US and resource-poor countries. Many studies have shared end-points, which include oral diseases known to be associated with HIV/AIDS measured by trained and calibrated ACTG study nurses. In preparation for future protocols, we have updated existing diagnostic criteria of the oral manifestations of HIV published in 1992 and 1993. The proposed case definitions are designed to be used in large-scale epidemiologic studies and clinical trials, in both US and resource-poor settings, where diagnoses may be made by non-dental healthcare providers. The objective of this article is to present updated case definitions for HIV-related oral diseases that will be used to measure standardized clinical end-points in OHARA studies, and that can be used by any investigator outside of OHARA/ACTG conducting clinical research that pertains to these end-points.

  17. Parameters of Time-out: Research Update and Comparison to Parenting Programs, Books, and Online Recommendations.

    Science.gov (United States)

    Corralejo, Samantha M; Jensen, Scott A; Greathouse, Ashley D; Ward, Leah E

    2018-01-01

    In reviews published more than 30 years ago, eight parameters important to the use of time-out were identified and available research was summarized. The purpose of the current paper is to provide an updated summary of existing research for each parameter of time-out. Within each parameter, we conducted a thorough review of the published literature and identified all peer-reviewed articles addressing each parameter. We identified and summarized a total of 46 articles across the eight parameters, including 32 not cited in previous reviews. Sufficient findings were available to draw conclusions regarding time-out warning, schedule of time-out, contingent versus noncontingent release, and duration. Tentative conclusions based on only a few studies could be drawn in regard to instructional versus physical administration and verbalized reason for time-out. No conclusions could be drawn regarding time-out signal and specific time-out location. While we know much more today regarding effective implementation of time-out, there is a clear need for further exploration within these identified parameters. In addition to summarizing the literature, we reviewed recommendations made by behavioral parent training programs, parenting books, and parenting Web sites, and compared how well their recommendations matched current research based on the conclusions drawn from our review. We found that parenting sources made strong and specific recommendations on several of the parameters that were either not consistent with available research or simply lacked a sufficient research base. Copyright © 2017. Published by Elsevier Ltd.

  18. GSD Update: Year in Review: Spotlight on 2017 Research by the Grassland, Shrubland and Desert Ecosystems Science Program

    Science.gov (United States)

    Deborah M. Finch

    2018-01-01

    In this issue of the GSD Update, we feature selected studies of the RMRS Grassland, Shrubland and Desert Ecosystems Science Program (GSD) that focus on the theme of fire. Significant results of recent research and science delivery by GSD scientists are highlighted. We feature program research that lines up with the strategic priorities and goals of the USDA Forest...

  19. FY16 ASC ATDM L2 Milestone: PARTISN Research and FleCSI Updates

    Energy Technology Data Exchange (ETDEWEB)

    Womeldorff, Geoffrey Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Payne, Joshua Estes [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Bergen, Benjamin Karl [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-09-01

    These are slides for a presentation on PARTISN Research and FleCSI Updates. The following topics are covered: SNAP vs PARTISN, Background Research, Production Code (structural design and changes, kernel design and implementation, lessons learned), NuT IMC Proxy, FleCSI Update (design and lessons learned). It can all be summarized in the following manner: Kokkos was shown to be effective in FY15 in implementing a C++ version of SNAP's kernel. This same methodology was applied to a production IC code, PARTISN. This was a much more complex endeavour than in FY15 for many reasons; a C++ kernel embedded in Fortran, overloading Fortran memory allocations, general language interoperability, and a fully fleshed out production code versus a simplified proxy code. Lessons learned are Legion. In no particular order: Interoperability between Fortran and C++ was really not that hard, and a useful engineering effort. Tracking down all necessary memory allocations for a kernel in a production code is pretty hard. Modifying a production code to work for more than a handful of use cases is also pretty hard. Figuring out the toolchain that will allow a successful implementation of design decisions is quite hard, if making use of "bleeding edge" design choices. In terms of performance, production code concurrency architecture can be a virtual showstopper; being too complex to easily rewrite and test in a short period of time, or depending on tool features which do not exist yet. Ultimately, while the tools used in this work were not successful in speeding up the production code, they helped to identify how work would be done, and provide requirements to tools.

  20. The Dissociative Subtype of Post-traumatic Stress Disorder: Research Update on Clinical and Neurobiological Features.

    Science.gov (United States)

    van Huijstee, Jytte; Vermetten, Eric

    2017-10-21

    Recently, a dissociative subtype of post-traumatic stress disorder (PTSD) has been included in the DSM-5. This review focuses on the clinical and neurobiological features that distinguish the dissociative subtype of PTSD from non-dissociative PTSD. Clinically, the dissociative subtype of PTSD is associated with high PTSD severity, predominance of derealization and depersonalization symptoms, a more significant history of early life trauma, and higher levels of comorbid psychiatric disorders. Furthermore, PTSD patients with dissociative symptoms exhibit different psychophysiological and neural responses to the recall of traumatic memories. While individuals with non-dissociative PTSD exhibit an increased heart rate, decreased activation of prefrontal regions, and increased activation of the amygdala in response to traumatic reminders, individuals with the dissociative subtype of PTSD show an opposite pattern. It has been proposed that dissociation is a regulatory strategy to restrain extreme arousal in PTSD through hyperinhibition of limbic regions. In this research update, promises and pitfalls in current research studies on the dissociative subtype of PTSD are listed. Inclusion of the dissociative subtype of PTSD in the DSM-5 stimulates research on the prevalence, symptomatology, and neurobiology of the dissociative subtype of PTSD and poses a challenge to improve treatment outcome in PTSD patients with dissociative symptoms.

  1. A bibliometric analysis of research updates and tendencies on steroid biotransformation

    Science.gov (United States)

    Song, Zhaoyu

    2018-03-01

    Steroid biotransformation, as a powerful tool for generation of steroid active pharmaceutical ingredients and key intermediates, has received widespread attention with increasing market demand for steroid-based drugs. In our study, a bibliometric analysis of steroid biotransformation was performed to trace the research updates and tendencies from 1993 to 2016, based on the Science Citation Index Expanded (SCIE) database. Results showed a notable growth trend in publication outputs. Although the USA was the most productive country between 1993 and 2016, developing nations, including China and India, contributed the prominent growth in recent years (2005–2016). Steroids was the leading journal in this field, and the research outputs had notably increased in the field of ‘Chemistry’, ‘Pharmacology and Pharmacy’ and ‘Biotechnology and Applied Microbiology’. Finally, research focused mainly on the efficient production of novel steroid active pharmaceutical ingredients and key intermediates through steroid biotransformation. Furthermore, cytochrome P450 involved in the side-chain oxidation of sterols has gradually become a hotspot issue in recent years.

  2. Update on Psychological Trauma, Other Severe Adverse Experiences and Eating Disorders: State of the Research and Future Research Directions.

    Science.gov (United States)

    Trottier, Kathryn; MacDonald, Danielle E

    2017-08-01

    This paper provides an updated review of the literature on the relationship between psychological trauma exposure, other severe adverse experiences, and eating disorders. Trauma exposure and other severe adverse experiences (e.g., emotional abuse) in both childhood and adulthood are associated with eating disorders. The relationship between traumatic and other adverse experiences and eating disorders appears to be mediated by emotional and behavioral dysregulation, as well as by cognitive factors such as self-criticism. Biological vulnerabilities may also be relevant to this relationship. Overall, the literature is limited by predominantly cross-sectional designs. There is clear evidence of a correlational relationship between trauma exposure and other severe adverse events, and eating disorders. Both risk and maintenance factor hypotheses have been put forth; however, prospective research testing these hypotheses remains limited. Future research should use prospective designs and focus on trauma-related symptoms (rather than trauma exposure) in order to advance research on risk and maintaining factors for eating disorders and inform treatment directions.

  3. New research on anxiety disorders in the elderly and an update on evidence-based treatments.

    Science.gov (United States)

    Andreescu, Carmen; Varon, Daniel

    2015-07-01

    Anxiety disorders are frequently encountered in the elderly, but they are largely undetected and untreated. Epidemiological studies indicate a prevalence ranging from 1.2 to 15 %. With the exception of generalized anxiety disorder and agoraphobia, which can often start in late life, most anxiety disorders in older patients are chronic and have their onset earlier in life. Anxiety disorders are an often unrecognized cause of distress, disability, and mortality risk in older adults, and they have been associated with cardiovascular disease, stroke, and cognitive decline. The mechanisms of anxiety in older adults differ from that in younger adults due to age-related neuropathology, as well as the loss and isolation so prominent in late life. Our review intends to provide a comprehensive summary of the most recent research done in the field of anxiety disorders in the elderly. Recent findings in clinical research, neuroimaging, neuroendocrinology, and neuropsychology are covered. An update on treatment options is discussed, including pharmacological and non-pharmacological alternatives.

  4. Experimental liver fibrosis research: update on animal models, legal issues and translational aspects

    Science.gov (United States)

    2013-01-01

    Liver fibrosis is defined as excessive extracellular matrix deposition and is based on complex interactions between matrix-producing hepatic stellate cells and an abundance of liver-resident and infiltrating cells. Investigation of these processes requires in vitro and in vivo experimental work in animals. However, the use of animals in translational research will be increasingly challenged, at least in countries of the European Union, because of the adoption of new animal welfare rules in 2013. These rules will create an urgent need for optimized standard operating procedures regarding animal experimentation and improved international communication in the liver fibrosis community. This review gives an update on current animal models, techniques and underlying pathomechanisms with the aim of fostering a critical discussion of the limitations and potential of up-to-date animal experimentation. We discuss potential complications in experimental liver fibrosis and provide examples of how the findings of studies in which these models are used can be translated to human disease and therapy. In this review, we want to motivate the international community to design more standardized animal models which might help to address the legally requested replacement, refinement and reduction of animals in fibrosis research. PMID:24274743

  5. Problem gambling worldwide: An update and systematic review of empirical research (2000-2015).

    Science.gov (United States)

    Calado, Filipa; Griffiths, Mark D

    2016-12-01

    Background and aims Problem gambling has been identified as an emergent public health issue, and there is a need to identify gambling trends and to regularly update worldwide gambling prevalence rates. This paper aims to review recent research on adult gambling and problem gambling (since 2000) and then, in the context of a growing liberalization of the gambling market in the European Union, intends to provide a more detailed analysis of adult gambling behavior across European countries. Methods A systematic literature search was carried out using academic databases, Internet, and governmental websites. Results Following this search and utilizing exclusion criteria, 69 studies on adult gambling prevalence were identified. These studies demonstrated that there are wide variations in past-year problem gambling rates across different countries in the world (0.12-5.8%) and in Europe (0.12-3.4%). However, it is difficult to directly compare studies due to different methodological procedures, instruments, cut-offs, and time frames. Despite the variability among instruments, some consistent results with regard to demographics were found. Discussion and conclusion The findings highlight the need for continuous monitoring of problem gambling prevalence rates in order to examine the influence of cultural context on gambling patterns, assess the effectiveness of policies on gambling-related harms, and establish priorities for future research.

  6. Problem gambling worldwide: An update and systematic review of empirical research (2000–2015)

    Science.gov (United States)

    Calado, Filipa; Griffiths, Mark D.

    2016-01-01

    Background and aims Problem gambling has been identified as an emergent public health issue, and there is a need to identify gambling trends and to regularly update worldwide gambling prevalence rates. This paper aims to review recent research on adult gambling and problem gambling (since 2000) and then, in the context of a growing liberalization of the gambling market in the European Union, intends to provide a more detailed analysis of adult gambling behavior across European countries. Methods A systematic literature search was carried out using academic databases, Internet, and governmental websites. Results Following this search and utilizing exclusion criteria, 69 studies on adult gambling prevalence were identified. These studies demonstrated that there are wide variations in past-year problem gambling rates across different countries in the world (0.12–5.8%) and in Europe (0.12–3.4%). However, it is difficult to directly compare studies due to different methodological procedures, instruments, cut-offs, and time frames. Despite the variability among instruments, some consistent results with regard to demographics were found. Discussion and conclusion The findings highlight the need for continuous monitoring of problem gambling prevalence rates in order to examine the influence of cultural context on gambling patterns, assess the effectiveness of policies on gambling-related harms, and establish priorities for future research. PMID:27784180

  7. The OMERACT MRI in Arthritis Working Group - Update on Status and Future Research Priorities.

    Science.gov (United States)

    Østergaard, Mikkel; Bird, Paul; Gandjbakhch, Frédérique; Eshed, Iris; Haugen, Ida K; Haavardsholm, Espen A; Lillegraven, Siri; Foltz, Violaine; Glinatsi, Daniel; Peterfy, Charles; Ejbjerg, Bo; Bøyesen, Pernille; Mease, Philip J; Hermann, Kay-Geert; Emery, Paul; Genant, Harry K; Conaghan, Philip G

    2015-12-01

    To provide an update on the status and future research priorities of the Outcome Measures in Rheumatology (OMERACT) magnetic resonance imaging (MRI) in arthritis working group. A summary is provided of the activities of the group within rheumatoid arthritis (RA), psoriatic arthritis (PsA), and osteoarthritis (OA), and its research priorities. The OMERACT RA MRI score (RAMRIS) evaluating bone erosion, bone edema (osteitis), and synovitis is now the standard method of quantifying articular pathology in RA trials. Cartilage loss is another important part of joint damage, and at the OMERACT 12 conference, we provided longitudinal data demonstrating reliability and sensitivity to change of the RAMRIS JSN component score, supporting its use in future clinical trials. The MRI group has previously developed a PsA MRI score (PsAMRIS). At OMERACT 12, PsAMRIS was evaluated in a randomized placebo-controlled trial of patients with PsA, demonstrating the responsiveness and discriminatory ability of applying the PsAMRIS to hands and feet. A hand OA MRI score (HOAMRIS) was introduced at OMERACT 11, and has subsequently been further validated. At OMERACT 12, good cross-sectional interreader reliability, but variable reliability of change scores, were reported. Potential future research areas were identified at the MRI session at OMERACT 12 including assessment of tenosynovitis in RA and enthesitis in PsA and focusing on alternative MRI techniques. MRI has been further developed and validated as an outcome measure in RA, PsA, and OA. The group will continue its efforts to optimize the value of MRI as a robust biomarker in rheumatology clinical trials.

  8. Medicare Part D research highlights and policy updates, 2013: impact and insights.

    Science.gov (United States)

    Stubbings, JoAnn; Lau, Denys T

    2013-04-01

    Since its implementation in 2006, Medicare Part D has evolved from a program that offered basic access to covered drugs for beneficiaries to one that has the potential to affect patient outcomes. The purpose of this article was to highlight key research findings on Medicare Part D published in 2012 and major public policy initiatives for Part D for 2013. PubMed/MEDLINE was searched for research studies on Part D published in 2012 in biomedical/scientific, peer-reviewed, English-language journals. For policy updates, sources included the Federal Register, the 2013 Final Call Letter, guidance from the Centers for Medicare and Medicaid Services, and 2012 publications on Part D policy identified in PubMed. Part D has been associated with higher medication use and lower out-of-pocket (OOP) costs of many long-term medications; however, differences within subgroups of beneficiaries have been observed. Studies on health outcomes have been inconclusive. Part D policy changes in 2013 have addressed problems with the benefit, namely coverage of benzodiazepines and barbiturates; reducing coinsurance in the coverage gap; reducing fraud, waste, and abuse; medication therapy management program standardization; and an expanded appeals process. Research continues to suggest that Part D is effective in increasing medication utilization and lowering OOP costs. Further work is needed to clarify the effects of Part D on nondrug health care service utilization and health outcomes. Policy changes for 2013 addressed specific improvements in the Medicare Part D benefit while potentially generating cost-savings for Medicare and Medicaid. Future challenges include alleviating access burden to medications during the phase-out of the coverage gap, minimizing disparities among Part D beneficiaries, and coordinating the Part D benefit with Medicare parts A and B via Medicare Accountable Care Organizations. A more integrated and coordinated Medicare benefit among all of its components would

  9. Comparative Study on Cyber Securities between Power Reactor and Research Reactor with Bayesian Update

    International Nuclear Information System (INIS)

    Shin, Jinsoo; Heo, Gyunyoung; Son, Han Seong

    2016-01-01

    The Stuxnet has shown that nuclear facilities are no more safe from cyber-attack. Due to practical experiences and concerns on increasing of digital system application, cyber security has become the important issue in nuclear industry. Korea Institute of Nuclear Nonproliferation and control (KINAC) published a regulatory standard (KINAC/RS-015) to establish cyber security framework for nuclear facilities. However, it is difficult to research about cyber security. It is hard to quantify cyber-attack which has malicious activity which is different from existing design basis accidents (DBAs). We previously proposed a methodology on development of a cyber security risk model with BBN. However, the methodology had a limitation in which the input data as prior information was solely on expert opinions. In this study, we propose a cyber security risk model for instrumentation and control (I and C) system of nuclear facilities with some equation for quantification by using Bayesian Belief Network (BBN) in order to overcome the limitation of previous research. The proposed model has been used for comparative study on cyber securities between large-sized nuclear power plants (NPPs) and small-sized Research Reactors (RR). In this study, we proposed the cyber security risk evaluation model with BBN. It includes I and C architecture, which is a target system of cyber-attack, malicious activity, which causes cyber-attack from attacker, and mitigation measure, which mitigates the cyber-attack risk. Likelihood and consequence as prior information are evaluated by considering characteristics of I and C architecture and malicious activity. The BBN model provides posterior information with Bayesian update by adding any of assumed cyber-attack scenarios as evidence. Cyber security risk for nuclear facilities is analyzed by comparing between prior information and posterior information of each node. In this study, we conducted comparative study on cyber securities between power reactor

  10. An updated h-index measures both the primary and total scientific output of a researcher.

    Science.gov (United States)

    Bucur, Octavian; Almasan, Alex; Zubarev, Roman; Friedman, Mark; Nicolson, Garth L; Sumazin, Pavel; Leabu, Mircea; Nikolajczyk, Barbara S; Avram, Dorina; Kunej, Tanja; Calin, George A; Godwin, Andrew K; Adami, Hans-Olov; Zaphiropoulos, Peter G; Richardson, Des R; Schmitt-Ulms, Gerold; Westerblad, Håkan; Keniry, Megan; Grau, Georges E R; Carbonetto, Salvatore; Stan, Radu V; Popa-Wagner, Aurel; Takhar, Kasumov; Baron, Beverly W; Galardy, Paul J; Yang, Feng; Data, Dipak; Fadare, Oluwole; Yeo, Kt Jerry; Gabreanu, Georgiana R; Andrei, Stefan; Soare, Georgiana R; Nelson, Mark A; Liehn, Elisa A

    2015-01-01

    The growing interest in scientometry stems from ethical concerns related to the proper evaluation of scientific contributions of an author working in a hard science. In the absence of a consensus, institutions may use arbitrary methods for evaluating scientists for employment and promotion. There are several indices in use that attempt to establish the most appropriate and suggestive position of any scientist in the field he/she works in. A scientist's Hirsch-index (h-index) quantifies their total effective published output, but h-index summarizes the total value of their published work without regard to their contribution to each publication. Consequently, articles where the author was a primary contributor carry the same weight as articles where the author played a minor role. Thus, we propose an updated h-index named Hirsch(p,t)-index that informs about both total scientific output and output where the author played a primary role. Our measure, h(p,t) = h(p),h(t), is composed of the h-index h(t) and the h-index calculated for articles where the author was a key contributor; i.e. first/shared first or senior or corresponding author. Thus, a h(p,t) = 5,10 would mean that the author has 5 articles as first, shared first, senior or corresponding author with at least 5 citations each, and 10 total articles with at least 10 citations each. This index can be applied in biomedical disciplines and in all areas where the first and last position on an article are the most important. Although other indexes, such as r- and w-indexes, were proposed for measuring the authors output based on the position of researchers within the published articles, our simpler strategy uses the already established algorithms for h-index calculation and may be more practical to implement.

  11. Updating Photonuclear Data Library and Generating a Reference Database for Photon Strength Functions. 1st Research Coordination Meeting. Summary Report

    International Nuclear Information System (INIS)

    Goriely, S.; Dimitriou, P.

    2016-07-01

    A summary is given of the 1 st Research Coordination Meeting of the new IAEA Co-ordinated Research Project (CRP) on Updating the Photonuclear Data Library and Generating a Reference Database for Photon Strength Functions. Participants presented their work, reviewed the current status of the field with regards to measurements, theoretical models and evaluations, discussed the scope of the work to be undertaken and agreed on a list of priorities and task assignments necessary to achieve the goals of the CRP. A summary of the presentations and discussions is presented in this report. (author)

  12. Research of Cadastral Data Modelling and Database Updating Based on Spatio-temporal Process

    Directory of Open Access Journals (Sweden)

    ZHANG Feng

    2016-02-01

    Full Text Available The core of modern cadastre management is to renew the cadastre database and keep its currentness,topology consistency and integrity.This paper analyzed the changes and their linkage of various cadastral objects in the update process.Combined object-oriented modeling technique with spatio-temporal objects' evolution express,the paper proposed a cadastral data updating model based on the spatio-temporal process according to people's thought.Change rules based on the spatio-temporal topological relations of evolution cadastral spatio-temporal objects are drafted and further more cascade updating and history back trace of cadastral features,land use and buildings are realized.This model implemented in cadastral management system-ReGIS.Achieved cascade changes are triggered by the direct driving force or perceived external events.The system records spatio-temporal objects' evolution process to facilitate the reconstruction of history,change tracking,analysis and forecasting future changes.

  13. The factor structure of posttraumatic stress disorder: a literature update, critique of methodology, and agenda for future research.

    Science.gov (United States)

    Elhai, Jon D; Palmieri, Patrick A

    2011-08-01

    We present an update of recent literature (since 2007) exploring the factor structure of posttraumatic stress disorder (PTSD) symptom measures. Research supporting a four-factor emotional numbing model and a four-factor dysphoria model is presented, with these models fitting better than all other models examined. Variables accounting for factor structure differences are reviewed, including PTSD query instructions, type of PTSD measure, extent of trauma exposure, ethnicity, and timing of administration. Methodological and statistical limitations with recent studies are presented. Finally, a research agenda and recommendations are offered to push this research area forward, including suggestions to validate PTSD’s factors against external measures of psychopathology, test moderators of factor structure, and examine heterogeneity of symptom presentations based on factor structure examination.

  14. Update on research and application of problem-based learning in medical science education.

    Science.gov (United States)

    Fan, Chuifeng; Jiang, Biying; Shi, Xiuying; Wang, Enhua; Li, Qingchang

    2017-12-29

    Problem-based learning (PBL) is a unique form of pedagogy dedicated to developing students' self-learning and clinical practice skills. After several decades of development, although applications vary, PBL has been recognized all over the world and implemented by many medical schools. This review summarizes and updates the application and study of PBL in medical education through the literature published between 1993 and early 2017. It focuses on understanding real medical PBL courses and ways to improve PBL to achieve better learning outcomes. PBL aims to develop lifelong skills to solve practical problems rather than limiting learning to theoretical knowledge. To achieve this goal, strict and reasonable procedures need to be designed and implemented. Rigorous monitoring and timely feedback and evaluation are indispensable to constant improvements and perfecting of the process. © 2017 by The International Union of Biochemistry and Molecular Biology, 2017. © 2018 The International Union of Biochemistry and Molecular Biology.

  15. The impact of marijuana policies on youth: clinical, research, and legal update.

    Science.gov (United States)

    Ammerman, Seth; Ryan, Sheryl; Adelman, William P

    2015-03-01

    This technical report updates the 2004 American Academy of Pediatrics technical report on the legalization of marijuana. Current epidemiology of marijuana use is presented, as are definitions and biology of marijuana compounds, side effects of marijuana use, and effects of use on adolescent brain development. Issues concerning medical marijuana specifically are also addressed. Concerning legalization of marijuana, 4 different approaches in the United States are discussed: legalization of marijuana solely for medical purposes, decriminalization of recreational use of marijuana, legalization of recreational use of marijuana, and criminal prosecution of recreational (and medical) use of marijuana. These approaches are compared, and the latest available data are presented to aid in forming public policy. The effects on youth of criminal penalties for marijuana use and possession are also addressed, as are the effects or potential effects of the other 3 policy approaches on adolescent marijuana use. Recommendations are included in the accompanying policy statement. Copyright © 2015 by the American Academy of Pediatrics.

  16. Updated list of ant species (Hymenoptera, Formicidae) recorded in Santa Catarina State, southern Brazil, with a discussion of research advances and priorities

    OpenAIRE

    Ulysséa,Mônica A.; Cereto,Carlos E.; Rosumek,Félix B.; Silva,Rogério R.; Lopes,Benedito C.

    2011-01-01

    Updated list of ant species (Hymenoptera, Formicidae) recorded in Santa Catarina State, southern Brazil, with a discussion of research advances and priorities. A first working list of ant species registered in Santa Catarina State, southern Brazil was published recently. Since then, many studies with ants have been conducted in the state. With data compiled from published studies and collections in various regions of the state, we present here an updated list of 366 species (and 17 subspecies...

  17. 78 FR 4150 - Update of NIOSH Nanotechnology Strategic Plan for Research and Guidance

    Science.gov (United States)

    2013-01-18

    ... for Disease Control and Prevention (CDC) has pioneered research on the toxicological properties and characteristics of nanoparticles. This research has involved characterizing occupationally relevant nanoparticles...) applications. NIOSH is considering focusing the overarching strategic research goals for these critical areas...

  18. International topical meeting on research reactor fuel management (RRFM) - United States foreign research reactor (FRR) spent nuclear fuel (SNF) acceptance program: 2010 update

    International Nuclear Information System (INIS)

    Messick, C.E.; Taylor, J.L.; Niehus, M.T.; Landers, C.

    2010-01-01

    The Nuclear Weapons Nonproliferation Policy Concerning Foreign Research Reactor Spent Nuclear Fuel, adopted by the United States Department of Energy (DOE), in consultation with the Department of State (DOS) in May 1996, scheduled to expire May 12, 2016, to return research reactor fuel until May 12, 2019 to the U.S. is in its fourteenth year. This paper provides a brief update on the program, part of the National Nuclear Security Administration (NNSA), and discusses program initiatives and future activities. The goal of the program continues to be recovery of U.S.-origin nuclear materials, which could otherwise be used in weapons, while assisting other countries to enjoy the benefits of nuclear technology. The NNSA is seeking feedback from research reactor operators to help us understand ways to include eligible research reactors who have not yet participated in the program. (author)

  19. Mechanisms of change in psychotherapy for depression: An empirical update and evaluation of research aimed at identifying psychological mediators.

    Science.gov (United States)

    Lemmens, Lotte H J M; Müller, Viola N L S; Arntz, Arnoud; Huibers, Marcus J H

    2016-12-01

    We present a systematic empirical update and critical evaluation of the current status of research aimed at identifying a variety of psychological mediators in various forms of psychotherapy for depression. We summarize study characteristics and results of 35 relevant studies, and discuss the extent to which these studies meet several important requirements for mechanism research. Our review indicates that in spite of increased attention for the topic, advances in theoretical consensus about necessities for mechanism research, and sophistication of study designs, research in this field is still heterogeneous and unsatisfactory in methodological respect. Probably the biggest challenge in the field is demonstrating the causal relation between change in the mediator and change in depressive symptoms. The field would benefit from a further refinement of research methods to identify processes of therapeutic change. Recommendations for future research are discussed. However, even in the most optimal research designs, explaining psychotherapeutic change remains a challenge. Psychotherapy is a multi-dimensional phenomenon that might work through interplay of multiple mechanisms at several levels. As a result, it might be too complex to be explained in relatively simple causal models of psychological change. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Update on ongoing tank car crashworthiness research : predicted performance and fabrication approach

    Science.gov (United States)

    2008-04-22

    Research is currently underway to develop strategies for maintaining the structural integrity of railroad tank cars carrying hazardous materials during collisions. This research, sponsored by the Federal Railroad Administration (FRA), has focused on ...

  1. NHTSA's behavioral safety research: updated, annotated bibliography, 1985-2013 : traffic tech.

    Science.gov (United States)

    2014-01-01

    Through many name changes, from the Office of Program : Development and Evaluation, the Office of Research and : Evaluation, to the current Office of Behavioral Safety Research, : our focus has remained on improving the safety of drivers, : occupants...

  2. 76 FR 12361 - Request for Information: Update of NIOSH Nanotechnology Strategic Plan for Research and Guidance

    Science.gov (United States)

    2011-03-07

    ... Control and Prevention (CDC) has pioneered research on the toxicological properties and characteristics of nanoparticles. This research has involved characterizing occupationally relevant nanoparticles for predicting... explosion safety, (8) recommendations and guidance, (9) communication and information, and (10) applications...

  3. The impact of marijuana policies on youth: clinical, research, and legal update.

    Science.gov (United States)

    2015-03-01

    This policy statement is an update of the American Academy of Pediatrics policy statement "Legalization of Marijuana: Potential Impact on Youth," published in 2004. Pediatricians have special expertise in the care of children and adolescents and may be called on to advise legislators about the potential impact of changes in the legal status of marijuana on adolescents. Parents also may look to pediatricians for advice as they consider whether to support state-level initiatives that propose to legalize the use of marijuana for medical and nonmedical purposes or to decriminalize the possession of small amounts of marijuana. This policy statement provides the position of the American Academy of Pediatrics on the issue of marijuana legalization. The accompanying technical report reviews what is currently known about the relationships of marijuana use with health and the developing brain and the legal status of marijuana and adolescents' use of marijuana to better understand how change in legal status might influence the degree of marijuana use by adolescents in the future. Copyright © 2015 by the American Academy of Pediatrics.

  4. Research in Progress--Update April 1990. Occasional Paper InTER/14/90.

    Science.gov (United States)

    Boots, Maureen, Comp.

    This document contains abstracts of 29 research projects in progress in Great Britain divided into six sections: (1) the current phase of Information Technology in Education Research (InTER) programs on groupwork with computers, tools for exploratory learning, conceptual change in science, and bubble dialogue as an ethnographic research tool; (2)…

  5. The Society of Thoracic Surgeons General Thoracic Surgery Database: 2017 Update on Research.

    Science.gov (United States)

    Gaissert, Henning A; Fernandez, Felix G; Crabtree, Traves; Burfeind, William R; Allen, Mark S; Block, Mark I; Schipper, Paul H; Jacobs, Jeffrey P; Habib, Robert H; Shahian, David M

    2017-11-01

    The outcomes research efforts based on The Society of Thoracic Surgeons (STS) General Thoracic Surgery Database include two established research programs with dedicated task forces and with data analyses conducted at the STS data analytic center: (1) The STS-sponsored research by the Access and Publications program, and (2) grant and institutionally funded research by the Longitudinal Follow-Up and Linked Registries Task Force. Also, the STS recently introduced the research program enabling investigative teams to apply for access to deidentified patient-level General Thoracic Surgery Database data sets and conduct related analyses at their own institution. Last year's General Thoracic Surgery Database-based research publications and the new Participant User File research program are reviewed. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  6. An update of research examining college student alcohol-related consequences: new perspectives and implications for interventions.

    Science.gov (United States)

    Mallett, Kimberly A; Varvil-Weld, Lindsey; Borsari, Brian; Read, Jennifer P; Neighbors, Clayton; White, Helene R

    2013-05-01

    The objective of this review is to provide an update on existing research examining alcohol-related consequences among college students with relevance for individual-based interventions. While alcohol-related consequences have been a focus of study for several decades, the literature has evolved into an increasingly nuanced understanding of individual and environmental circumstances that contribute to risk of experiencing consequences. A number of risk factors for experiencing alcohol-related consequences have been identified, including belonging to specific student subgroups (e.g., Greek organizations) or drinking during high-risk periods, such as spring break. In addition, the relationship between students' evaluations of both negative and positive consequences and their future drinking behavior has become a focus of research. The current review provides an overview of high-risk student subpopulations, high-risk windows and activities, and college students' subjective evaluations of alcohol-related consequences. Future directions for research are discussed and include determining how students' orientations toward consequences change over time, identifying predictors of membership in high-risk consequence subgroups and refining existing measures of consequences to address evolving research questions. Copyright © 2012 by the Research Society on Alcoholism.

  7. Brain Chemistry and Behaviour: An Update on Neuroscience Research and Its Implications for Understanding Drug Addiction

    Science.gov (United States)

    Robinson, Emma S. J.

    2011-01-01

    Psychiatric disorders such as drug addiction represent one of the biggest challenges to society. This article reviews clinical and basic science research to illustrate how developments in research methodology have enabled neuroscientists to understand more about the brain mechanisms involved in addiction biology. Treating addiction represents a…

  8. Multiple sclerosis in children: an update on clinical diagnosis, therapeutic strategies, and research

    OpenAIRE

    Waldman, Amy; Ghezzi, Angelo; Bar-Or, Amit; Mikaeloff, Yann; Tardieu, Marc; Banwell, Brenda

    2014-01-01

    The clinical features, diagnostic challenges, neuroimaging appearance, therapeutic options, and pathobiological research progress in childhood—and adolescent—onset multiple sclerosis have been informed by many new insights in the past 7 years. National programmes in several countries, collaborative research efforts, and an established international paediatric multiple sclerosis study group have contributed to revised clinical diagnostic definitions, identified clinical features of multiple sc...

  9. ACL Research Retreat VI : An update on ACL injury risk and prevention

    NARCIS (Netherlands)

    R.J. Schmitz; M. Collins; D.A. Padua; Anne Benjaminse; A.M. Chaudhari; S.J. Schultz

    2012-01-01

    It has been well recognized that multiple factors, whether individually or in combination, contribute to noncontact anterior cruciate ligament (ACL) injury. The ongoing mission of the ACL Research Retreat is to bring clinicians and researchers together to present and discuss the most recent advances

  10. Update on radon-mitigation research in schools. Rept. for 1988-Aug 91

    International Nuclear Information System (INIS)

    Leovic, K.W.; Craig, A.B.; Harris, D.B.

    1991-01-01

    The paper is an overview of research by EPA's Air and Energy Engineering Research Laboratory (AEERL) on radon mitigation in 47 schools since 1988. The structural and heating, ventilating, and air-conditioning (HVAC) system characteristics of the research schools are presented, along with the mitigation techniques implemented in the schools. Research discussed includes recent and on-going projects in Colorado, Maine, Maryland, Ohio, South Dakota, Tennessee, and Virginia. Initial research focussed on the application of active subslab depressurization (ASD) to school buildings, and recent research has emphasized the ability and limitations of using HVAC systems to reduce radon levels in schools. A goal of future projects is to compare the effectiveness of the two techniques in the same building. Slab-on-grade is the most prevalent substructure in AEERL's research schools and, depending on pressure field extension, ASD systems have been recommended for radon control in many of them. In schools where they have been installed, ASD systems have performed well and are currently being evaluated for long-term performance. The distribution of HVAC system types in these schools is about a third central air handling systems, a third unit ventilators, and a third that do not supply conditioned outdoor air (i.e., fan coil units or radiant heat)

  11. Health data research in New Zealand: updating the ethical governance framework.

    Science.gov (United States)

    Ballantyne, Angela; Style, Rochelle

    2017-10-27

    Demand for health data for secondary research is increasing, both in New Zealand and worldwide. The New Zealand government has established a large research database, the Integrated Data Infrastructure (IDI), which facilitates research, and an independent ministerial advisory group, the Data Futures Partnership (DFP), to engage with citizens, the private sector and non-government organisations (NGOs) to facilitate trusted data use and strengthen the data ecosystem in New Zealand. We commend these steps but argue that key strategies for effective health-data governance remain absent in New Zealand. In particular, we argue in favour of the establishment of: (1) a specialist Health and Disability Ethics Committee (HDEC) to review applications for secondary-use data research; (2) a public registry of approved secondary-use research projects (similar to a clinical trials registry); and (3) detailed guidelines for the review and approval of secondary-use data research. We present an ethical framework based on the values of public interest, trust and transparency to justify these innovations.

  12. The use of Theory in Family Therapy Research: Content Analysis and Update.

    Science.gov (United States)

    Chen, Ruoxi; Hughes, Alexandria C; Austin, Jason P

    2017-07-01

    In this study, we evaluated 275 empirical studies from Journal of Marital and Family Therapy and Family Process from 2010 to 2015 on their use of theory, and compared our findings to those of a similar previous analysis (Hawley & Geske, 2000). Overall, theory seems to have become much better incorporated in empirical family therapy research, with only 16.4% of the articles not using theory in either their introductory or discussion sections. Theory appeared better incorporated in the introductory sections than in the discussion sections. Systems theory remained the most commonly used conceptual framework, followed by attachment theory. We discuss areas for improving theory incorporation in family therapy research, and offer suggestions for both family therapy researchers and educators. © 2017 American Association for Marriage and Family Therapy.

  13. The European society of gynaecological oncology: update on objectives and educational and research activities.

    Science.gov (United States)

    Brantnerova, Renata; Manchanda, Ranjit; Colombo, Nicoletta

    2012-01-01

    The European Society of Gynaecological Oncology (ESGO) is the principal European society contributing to the study, prevention, and treatment of gynecologic cancers. Founded in 1983, ESGO has more than 1,300 members in more than 40 European countries and worldwide who benefit from ESGO's innovative education and research initiatives and networking opportunities. ESGO objectives have been recently identified through a strategic planning process and include education, care, research, collaboration, awareness, and sustainability. As a leading gynecologic oncology society, ESGO holds biennial meetings where experts meet to discuss latest advances in gynecologic treatment and care. The 17(th) International Meeting of ESGO (ESGO 17) proved to be a resounding success, with 2,700 delegates and speakers who gathered from around the world in the cultured city of Milan, Italy. The structure of the congress included keynote lectures, debates, state-of-the art sessions, and focused sunrise sessions, together with oral and poster presentations and satellite symposia sponsored by pharmaceutical companies. For the first time, during ESGO 17 the Society organized a seminar for European patient groups with an interest in gynecologic cancers with the aim of facilitating different patientrelated activities across Europe. Moreover, The European Network of Young Gynaecologic Oncologists (ENYGO), the European Network of Gynaecologic Oncology Trial Groups (ENGOT), and the European Network of Translational Research in Gynaecological Oncology (ENTRIGO) had their own section during ESGO 17. ESGO also holds numerous workshops throughout the calendar year and provides clinical and research grants, online educational materials, webcasts, and numerous networking opportunities.

  14. Updating AP Potential™ Expectancy Tables Involving PSAT/NMSQT® Writing. Research Notes. RN-35

    Science.gov (United States)

    Ewing, Maureen; Camara, Wayne J.; Millsap, Roger E.; Milewski, Glenn B.

    2007-01-01

    AP Potential™ is a data-driven tool offered by the College Board that uses scores from the PSAT/NMSQT® to identify students who have the potential to succeed in Advanced Placement Program® (AP®) courses (College Board, 2007). Research showing a moderate-to-strong correlation between PSAT/NMSQT scores and AP Exam scores serves as the basis for this…

  15. A Free-Response Method of Computer Assisted Personality Assessment: A Research Update.

    Science.gov (United States)

    1987-07-08

    primacy tween "irrelevancies" and "intermedi- or recency effects would prove interes- ates." ting. For research purposes, it is help- Unfortunately, such a...fact is seen to fall midway on recency effect also is possible, where a given dimension, then its score is later-mentioned self-descriptors weigh

  16. Head and Spinal Cord Trauma Involving Youth Recreational Activities. Research Update.

    Science.gov (United States)

    McAleese, Willis J.; Scantling, Ed

    1996-01-01

    Summarizes what current research on head and spinal cord injuries sustained during participation in recreation has to offer practitioners in terms of awareness and possible preventive strategies. It noted that by addressing injury prevention through the health-belief model paradigm, recreation practitioners move a step beyond simply providing…

  17. Global foot-and-mouth disease research update and gap analysis: 2 - epidemiology, wildlife and economics

    Science.gov (United States)

    In 2014, the Global Foot-and-mouth disease Research ings in the fields of (i) epidemiology, (ii) wildlife and (iii) Alliance (GFRA) conducted a gap analysis of foot-and- economics. Although the three sections, epidemiology, wildlife and economics are presented as separate entities, the fields are ...

  18. HIGHLIGHTS OF THE RUSSIAN HEALTH STUDIES PROGRAM AND UPDATED RESEARCH FINDINGS.

    Science.gov (United States)

    Fountos, Barrett N

    2017-04-01

    Recognized for conducting cutting-edge science in the field of radiation health effects research, the Department of Energy's (DOE) Russian Health Studies Program has continued to generate excitement and enthusiasm throughout its 23-year mission to assess worker and public health risks from radiation exposure resulting from nuclear weapons production activities in the former Soviet Union. The three goals of the Program are to: (1) clarify the relationship between health effects and chronic, low-to-medium dose radiation exposure; (2) estimate the cancer risks from exposure to gamma, neutron, and alpha radiation; and (3) provide information to the national and international organizations that determine radiation protection standards and practices. Research sponsored by DOE's Russian Health Studies Program is conducted under the authority of the Joint Coordinating Committee for Radiation Effects Research (JCCRER), a bi-national committee representing Federal agencies in the United States and the Russian Federation. Signed in 1994, the JCCRER Agreement established the legal basis for the collaborative research between USA and Russian scientists to determine the risks associated with working at or living near Russian former nuclear weapons production sites. The products of the Program are peer-reviewed publications on cancer risk estimates from worker and community exposure to ionizing radiation following the production of nuclear weapons in Russia. The scientific return on investment has been substantial. Through 31 December 2015, JCCRER researchers have published 299 peer-reviewed publications. To date, the research has focused on the Mayak Production Association (Mayak) in Ozersk, Russia, which is the site of the first Soviet nuclear weapons production facility, and people in surrounding communities along the Techa River. There are five current projects in the Russian Health Studies Program: two radiation epidemiology studies; two historical dose reconstruction

  19. Highlights of the Russian health studies program and updated research findings

    International Nuclear Information System (INIS)

    Fountos, Barrett N.

    2017-01-01

    Recognized for conducting cutting-edge science in the field of radiation health effects research, the Department of Energy's (DOE) Russian Health Studies Program has continued to generate excitement and enthusiasm throughout its 23-year mission to assess worker and public health risks from radiation exposure resulting from nuclear weapons production activities in the former Soviet Union. The three goals of the Program are to: (1) clarify the relationship between health effects and chronic, low-to-medium dose radiation exposure; (2) estimate the cancer risks from exposure to gamma, neutron, and alpha radiation; and (3) provide information to the national and international organizations that determine radiation protection standards and practices. Research sponsored by DOE's Russian Health Studies Program is conducted under the authority of the Joint Coordinating Committee for Radiation Effects Research (JCCRER), a bi-national committee representing Federal agencies in the United States and the Russian Federation. Signed in 1994, the JCCRER Agreement established the legal basis for the collaborative research between USA and Russian scientists to determine the risks associated with working at or living near Russian former nuclear weapons production sites. The products of the Program are peer-reviewed publications on cancer risk estimates from worker and community exposure to ionizing radiation following the production of nuclear weapons in Russia. The scientific return on investment has been substantial. Through 31 December 2015, JCCRER researchers have published 299 peer-reviewed publications. To date, the research has focused on the Mayak Production Association (Mayak) in Ozersk, Russia, which is the site of the first Soviet nuclear weapons production facility, and people in surrounding communities along the Techa River. There are five current projects in the Russian Health Studies Program: two radiation epidemiology studies; two historical dose

  20. Substance Use in Lesbian, Gay, and Bisexual Populations: An Update on Empirical Research and Implications for Treatment

    Science.gov (United States)

    Green, Kelly E.; Feinstein, Brian A.

    2011-01-01

    Historically, substance use problems were thought to be more prevalent in lesbian, gay, and bisexual (LGB) populations, and correcting skewed perceptions about substance abuse among LGB individuals is critically important. This review provides an update on empirical evidence on LGB substance use patterns and treatment outcome, with specific focus on clinical implications of findings. Compared to earlier studies, the recent research included in this review has used more sophisticated methodologies, more representative samples, and also has investigated multiple dimensions of sexual orientation in relation to substance use patterns. Findings from recent research suggest that lesbians and bisexual women are at greater risk for alcohol and drug use disorders and related problems, and that gay and bisexual men are at greater risk for illicit drug use and related problems. Several sociocultural factors have emerged as correlates of substance use patterns in LGB populations (e.g., affiliation with gay culture, HIV-status), and several demographic characteristics (e.g., female, older age) do not appear to be as robust of protective factors against substance abuse for LGB individuals compared to heterosexual populations. Bisexual identity and/or behavior in particular seem to be related to increased risk for substance abuse. In terms of treatment outcome, limitations of extant research prevent conclusions about the relative impact of LGB-specific interventions, and further research that includes women and uses more equivalent comparison interventions is needed. Clinical implications of research findings are discussed for case identification, selection of treatment goals (e.g., moderation versus abstinence), targets for intervention, and specific treatment modalities. PMID:22061339

  1. malERA: An updated research agenda for malaria elimination and eradication.

    Directory of Open Access Journals (Sweden)

    Regina N Rabinovich

    2017-11-01

    Full Text Available Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by 2020. The commitment to achieve these targets should be celebrated. However, the need for innovation to achieve these goals, sustain elimination, and free the world of malaria is greater than ever. Over 180 experts across multiple disciplines are engaged in the Malaria Eradication Research Agenda (malERA Refresh process to address problems that need to be solved. The result is a research and development agenda to accelerate malaria elimination and, in the longer term, transform the malaria community's ability to eradicate it globally.

  2. canSAR: an updated cancer research and drug discovery knowledgebase.

    Science.gov (United States)

    Tym, Joseph E; Mitsopoulos, Costas; Coker, Elizabeth A; Razaz, Parisa; Schierz, Amanda C; Antolin, Albert A; Al-Lazikani, Bissan

    2016-01-04

    canSAR (http://cansar.icr.ac.uk) is a publicly available, multidisciplinary, cancer-focused knowledgebase developed to support cancer translational research and drug discovery. canSAR integrates genomic, protein, pharmacological, drug and chemical data with structural biology, protein networks and druggability data. canSAR is widely used to rapidly access information and help interpret experimental data in a translational and drug discovery context. Here we describe major enhancements to canSAR including new data, improved search and browsing capabilities, new disease and cancer cell line summaries and new and enhanced batch analysis tools. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  3. Research ethics in the era of personalized medicine: updating science's contract with society.

    Science.gov (United States)

    Meslin, Eric M; Cho, Mildred K

    2010-01-01

    With the completed sequence of the human genome has come the prospect of substantially improving the quality of life for millions through personalized medicine approaches. Still, any advances in this direction require research involving human subjects. For decades science and ethics have enjoyed an allegiance reflected in a common set of ethical principles and procedures guiding the conduct of research with human subjects. Some of these principles emphasize avoiding harm over maximizing benefit. In this paper we revisit the priority given to these ethical principles - particularly the principles that support a cautious approach to science - and propose a reframing of the 'social contract' between science and society that emphasizes reciprocity and meeting public needs.

  4. malERA: An updated research agenda for malaria elimination and eradication.

    Science.gov (United States)

    Rabinovich, Regina N; Drakeley, Chris; Djimde, Abdoulaye A; Hall, B Fenton; Hay, Simon I; Hemingway, Janet; Kaslow, David C; Noor, Abdisalan; Okumu, Fredros; Steketee, Richard; Tanner, Marcel; Wells, Timothy N C; Whittaker, Maxine A; Winzeler, Elizabeth A; Wirth, Dyann F; Whitfield, Kate; Alonso, Pedro L

    2017-11-01

    Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by 2020. The commitment to achieve these targets should be celebrated. However, the need for innovation to achieve these goals, sustain elimination, and free the world of malaria is greater than ever. Over 180 experts across multiple disciplines are engaged in the Malaria Eradication Research Agenda (malERA) Refresh process to address problems that need to be solved. The result is a research and development agenda to accelerate malaria elimination and, in the longer term, transform the malaria community's ability to eradicate it globally.

  5. What's new in the literature: an update of new research since the original WHS diabetic foot ulcer guidelines in 2006.

    Science.gov (United States)

    Braun, Liza; Kim, Paul J; Margolis, David; Peters, Edgar J; Lavery, Lawrence A

    2014-01-01

    The objective of the paper was to update the diabetic foot ulcer guidelines that were previously published in 2006. We performed a key word search using MEDLINE and Cochrane reviews for publication between January 2006 and January 2012. Articles that fit the inclusion criteria were reviewed and the previous guidelines were updated. © 2014 by the Wound Healing Society.

  6. Update of X- and γ-ray decay data standards for detector calibration and other applications. Summary report of the 1. research co-ordination meeting

    International Nuclear Information System (INIS)

    Herman, M.; Nichols, A.

    1999-07-01

    The discussions and conclusions of the First Research Co-ordination Meeting to Update X- and γ-ray Decay Data Standards for Detector Calibration are described in this summary report. The agreed list of radionuclides to be evaluated is given, along with the evaluation procedures and assignment of tasks among participants of the CRP. 14 presentations given at the meeting were indexed separately

  7. Recent Advances in Sarcopenia Research in Asia: 2016 Update From the Asian Working Group for Sarcopenia.

    Science.gov (United States)

    Chen, Liang-Kung; Lee, Wei-Ju; Peng, Li-Ning; Liu, Li-Kuo; Arai, Hidenori; Akishita, Masahiro

    2016-08-01

    Sarcopenia was recently classified a geriatric syndrome and is a major challenge to healthy aging. Affected patients tend to have worse clinical outcomes and higher mortality than those without sarcopenia. Although there is general agreement on the principal diagnostic characteristics, initial thresholds for muscle mass, strength, and physical performance were based on data from populations of predominantly Europid ancestry and may not apply worldwide. The Asian Working Group for Sarcopenia (AWGS) issued regional consensus guidelines in 2014, and many more research studies from Asia have since been published; this review summarizes recent progress. The prevalence of sarcopenia estimated by the AWGS criteria ranges between 4.1% and 11.5% of the general older population; however, prevalence rates were higher in Asian studies that used European Working Group on Sarcopenia in Older People cut-offs. Risk factors include age, sex, heart disease, hyperlipidemia, daily alcohol consumption, and low protein or vitamin intake; physical activity is protective. Adjusting skeletal muscle mass by weight rather than height is better in showing the effect of older age in sarcopenia and identifying sarcopenic obesity; however, some Asian studies found no significant skeletal muscle loss, and muscle strength might be a better indicator. Although AWGS 2014 diagnostic cut-offs were generally well accepted, some may require further revision in light of conflicting evidence from some studies. The importance of sarcopenia in diverse therapeutic areas is increasingly evident, with strong research interest in sarcopenic obesity and the setting of malignancy. Pharmacologic interventions have been unsatisfactory, and the core management strategies remain physical exercise and nutritional supplementation; however, further research is required to determine the most beneficial approaches. Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc

  8. The Large Synoptic Survey Telescope: A summary update on the scientific potential for pulsating star research

    Science.gov (United States)

    Graham, Melissa L.

    2017-09-01

    The Large Synoptic Survey Telescope (LSST) will provide hundreds of deep images of the southern sky over its 10 year duration, enabling variability studies for an unprecedentedly large and unbiased population of objects. In this proceeding paper I will cover the aspects of the LSST's survey and data products that are most relevant to the study of stellar pulsations (Sect. 1), and provide a directory of pertinent materials for further information. I will also summarize the anticipated variable star sample sizes from the LSST, and highlight recent research from several members of the scientific community which evaluates the scientific potential of the LSST's data products with respect to pulsating stars (Sect. 2).

  9. Research Update: Materials design of implantable nanogenerators for biomechanical energy harvesting

    Science.gov (United States)

    Li, Jun; Wang, Xudong

    2017-07-01

    Implantable nanogenerators are rapidly advanced recently as a promising concept for harvesting biomechanical energy in vivo. This review article presents an overview of the most current progress of implantable piezoelectric nanogenerator (PENG) and triboelectric nanogenerator (TENG) with a focus on materials selection, engineering, and assembly. The evolution of the PENG materials is discussed from ZnO nanostructures, to high-performance ferroelectric perovskites, to flexible piezoelectric polymer mesostructures. Discussion of TENGs is focused on the materials and surface features of friction layers, encapsulation materials, and device integrations. Challenges faced by this promising technology and possible future research directions are also discussed.

  10. Seed Biology Updates - Highlights and New Discoveries in Seed Dormancy and Germination Research.

    Science.gov (United States)

    Nonogaki, Hiroyuki

    2017-01-01

    An understanding of the biology of seeds has been greatly advanced in recent years. The progresses, particularly in the field of seed dormancy and germination research, have been made at a remarkable speed. Some of the possible epigenetic mechanisms, including an involvement of non-coding RNA, which were predicted for DELAY OF GERMINATION1 just a few years ago, have now been demonstrated with strong molecular and genetic evidence. Imprinting, or parent-of-origin-specific gene silencing/expression, which was characterized particularly for developing seeds, was also found in imbibed seeds and suggested for dormancy mechanisms. Hormone biology in seeds, which is the most advanced and almost a traditional area of seed research, also presents a new dimension. Upstream regulators of hormone metabolism and hormone transporters, such as abscisic acid and gibberellin influx/efflux carriers, have been identified. Characterization of the novel posttranslational modification pathways, including the N-end rule and S -nitrosylation pathways, which play a critical role in turnover of the major hormone signal transduction proteins, also expanded our knowledge about the complexity of hormone signaling in seeds. These progresses made at the molecular level are significant steps toward a better understanding of how seeds translate soil and other environmental signals into their internal hormone biology and make an important decision to stay dormant or commence with germination.

  11. An Update to Space Biomedical Research: Tissue Engineering in Microgravity Bioreactors

    Directory of Open Access Journals (Sweden)

    Abolfazl Barzegari

    2012-03-01

    Full Text Available Introduction: The severe need for constructing replacement tissues in organ transplantation has necessitated the development of tissue engineering approaches and bioreactors that can bring these approaches to reality. The inherent limitations of conventional bioreactors in generating realistic tissue constructs led to the devise of the microgravity tissue engineering that uses Rotating Wall Vessel (RWV bioreactors initially developed by NASA. Methods: In this review article, we intend to highlight some major advances and accomplishments in the rapidly-growing field of tissue engineering that could not be achieved without using microgravity. Results: Research is now focused on assembly of 3 dimensional (3D tissue fragments from various cell types in human body such as chondrocytes, osteoblasts, embryonic and mesenchymal stem cells, hepatocytes and pancreas islet cells. Hepatocytes cultured under microgravity are now being used in extracorporeal bioartificial liver devices. Tissue constructs can be used not only in organ replacement therapy, but also in pharmaco-toxicology and food safety assessment. 3D models of various cancers may be used in studying cancer development and biology or in high-throughput screening of anticancer drug candidates. Finally, 3D heterogeneous assemblies from cancer/immune cells provide models for immunotherapy of cancer. Conclusion: Tissue engineering in (simulated microgravity has been one of the stunning impacts of space research on biomedical sciences and their applications on earth.

  12. Multiple sclerosis in children: an update on clinical diagnosis, therapeutic strategies, and research.

    Science.gov (United States)

    Waldman, Amy; Ghezzi, Angelo; Bar-Or, Amit; Mikaeloff, Yann; Tardieu, Marc; Banwell, Brenda

    2014-09-01

    The clinical features, diagnostic challenges, neuroimaging appearance, therapeutic options, and pathobiological research progress in childhood-and adolescent-onset multiple sclerosis have been informed by many new insights in the past 7 years. National programmes in several countries, collaborative research efforts, and an established international paediatric multiple sclerosis study group have contributed to revised clinical diagnostic definitions, identified clinical features of multiple sclerosis that differ by age of onset, and made recommendations regarding the treatment of paediatric multiple sclerosis. The relative risks conveyed by genetic and environmental factors to paediatric multiple sclerosis have been the subject of several large cohort studies. MRI features have been characterised in terms of qualitative descriptions of lesion distribution and applicability of MRI aspects to multiple sclerosis diagnostic criteria, and quantitative studies have assessed total lesion burden and the effect of the disease on global and regional brain volume. Humoral-based and cell-based assays have identified antibodies against myelin, potassium-channel proteins, and T-cell profiles that support an adult-like T-cell repertoire and cellular reactivity against myelin in paediatric patients with multiple sclerosis. Finally, the safety and efficacy of standard first-line therapies in paediatric multiple sclerosis populations are now appreciated in more detail, and consensus views on the future conduct and feasibility of phase 3 trials for new drugs have been proposed. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. Nuclear power and the public: an update of collected survey research on nuclear power

    International Nuclear Information System (INIS)

    Rankin, W.L.; Melber, B.D.; Overcast, T.D.; Nealey, S.M.

    1981-12-01

    The purpose of this research was to collect, analyze, and summarize all of the nuclear power-related surveys conducted in the United States through June 1981, that we could obtain. The surveys collected were national, statewide, and areawide in scope. Slightly over 100 surveys were collected for an earlier, similar effort carried out in 1977. About 130 new surveys were added to the earlier survey data. Thus, about 230 surveys were screened for inclusion in this report. Because of space limitations, national surveys were used most frequently in this report, followed distantly by state surveys. In drawing our conclusions about public beliefs and attitudes toward nuclear power, we placed most of our confidence in survey questions that were used by national polling firms at several points in time. A summary of the research findings is presented, beginning with general attitudes toward nuclear power, followed by a summary of beliefs and attitudes about nuclear power issues, and ended by a summary of beliefs and attitudes regarding more general energy issues

  14. Multiple sclerosis in children: an update on clinical diagnosis, therapeutic strategies, and research

    Science.gov (United States)

    Waldman, Amy; Ghezzi, Angelo; Bar-Or, Amit; Mikaeloff, Yann; Tardieu, Marc; Banwell, Brenda

    2015-01-01

    The clinical features, diagnostic challenges, neuroimaging appearance, therapeutic options, and pathobiological research progress in childhood—and adolescent—onset multiple sclerosis have been informed by many new insights in the past 7 years. National programmes in several countries, collaborative research efforts, and an established international paediatric multiple sclerosis study group have contributed to revised clinical diagnostic definitions, identified clinical features of multiple sclerosis that differ by age of onset, and made recommendations regarding the treatment of paediatric multiple sclerosis. The relative risks conveyed by genetic and environmental factors to paediatric multiple sclerosis have been the subject of several large cohort studies. MRI features have been characterised in terms of qualitative descriptions of lesion distribution and applicability of MRI aspects to multiple sclerosis diagnostic criteria, and quantitative studies have assessed total lesion burden and the effect of the disease on global and regional brain volume. Humoral-based and cell-based assays have identified antibodies against myelin, potassium-channel proteins, and T-cell profiles that support an adult-like T-cell repertoire and cellular reactivity against myelin in paediatric patients with multiple sclerosis. Finally, the safety and efficacy of standard first-line therapies in paediatric multiple sclerosis populations are now appreciated in more detail, and consensus views on the future conduct and feasibility of phase 3 trials for new drugs have been proposed. PMID:25142460

  15. Nuclear power and the public: an update of collected survey research on nuclear power

    Energy Technology Data Exchange (ETDEWEB)

    Rankin, W.L.; Melber, B.D.; Overcast, T.D.; Nealey, S.M.

    1981-12-01

    The purpose of this research was to collect, analyze, and summarize all of the nuclear power-related surveys conducted in the United States through June 1981, that we could obtain. The surveys collected were national, statewide, and areawide in scope. Slightly over 100 surveys were collected for an earlier, similar effort carried out in 1977. About 130 new surveys were added to the earlier survey data. Thus, about 230 surveys were screened for inclusion in this report. Because of space limitations, national surveys were used most frequently in this report, followed distantly by state surveys. In drawing our conclusions about public beliefs and attitudes toward nuclear power, we placed most of our confidence in survey questions that were used by national polling firms at several points in time. A summary of the research findings is presented, beginning with general attitudes toward nuclear power, followed by a summary of beliefs and attitudes about nuclear power issues, and ended by a summary of beliefs and attitudes regarding more general energy issues.

  16. Research on animal cloning technologies and their implications in medical ethics: an update.

    Science.gov (United States)

    Revel, M

    2000-01-01

    Reproduction by cloning has been achieved by transfer into enucleated oocytes of nuclei from embryonic cells and more recently from cells of adult animals. The efficiency at which embryos produced by such nuclear transfers will develop into healthy newborns is very low but has allowed to produce some cloned bovines, bovines and mice. Since the first report of sheep cloning from an adult cell in 1997, the potential applications of reproductive cloning in human medicine have been envisaged amidst a flurry of moral debates. Although the technology is still far from being ready for any human use, it has been condemned from the outset. It has also led to irrational fantasies and fears mainly based on the misconception that genetic identity means identical twin personalities. Scientific research is ongoing on refining the cloning technology for applications in the production of genetically homogeneous farm animals with useful nutritional or therapeutic genetic traits. A new area of research is non-reproductive therapeutic cloning for the purpose of producing autologous embryonic cells and tissues for transplantation.

  17. Statistics Anxiety Update: Refining the Construct and Recommendations for a New Research Agenda.

    Science.gov (United States)

    Chew, Peter K H; Dillon, Denise B

    2014-03-01

    Appreciation of the importance of statistics literacy for citizens of a democracy has resulted in an increasing number of degree programs making statistics courses mandatory for university students. Unfortunately, empirical evidence suggests that students in nonmathematical disciplines (e.g., social sciences) regard statistics courses as the most anxiety-inducing course in their degree programs. Although a literature review exists for statistics anxiety, it was done more than a decade ago, and newer studies have since added findings for consideration. In this article, we provide a current review of the statistics anxiety literature. Specifically, related variables, definitions, and measures of statistics anxiety are reviewed with the goal of refining the statistics anxiety construct. Antecedents, effects, and interventions of statistics anxiety are also reviewed to provide recommendations for statistics instructors and for a new research agenda. © The Author(s) 2014.

  18. Update on Extended Operation of Stirling Convertors in Thermal Vacuum at NASA Glenn Research Center

    Science.gov (United States)

    Oriti, Salvatore M.

    2006-01-01

    The U.S. Department of Energy (DOE), Lockheed Martin Space Systems (LMSS), Infinia Corporation, and NASA Glenn Research Center (GRC) have been developing a Stirling Radioisotope Generator (SRG) for use as a power system on space science missions. This generator would make use of Stirling cycle energy conversion to achieve higher efficiency than currently used alternatives. A test has been initiated at GRC to demonstrate functionality of Stirling conversion in a thermal vacuum environment over an extended period of time. The test article resembles the configuration of the SRG, but was designed without the requirement of low mass. Throughout the 8700 cumulative hours of operation, modifications to the supporting hardware were required to attain the desired operating conditions. These modifications, the status of testing, and the data recorded will be discussed in this paper.

  19. Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research

    Directory of Open Access Journals (Sweden)

    Elena Mata

    2013-01-01

    Full Text Available There is no malaria vaccine currently available, and the most advanced candidate has recently reported a modest 30% efficacy against clinical malaria. Although many efforts have been dedicated to achieve this goal, the research was mainly directed to identify antigenic targets. Nevertheless, the latest progresses on understanding how immune system works and the data recovered from vaccination studies have conferred to the vaccine formulation its deserved relevance. Additionally to the antigen nature, the manner in which it is presented (delivery adjuvants as well as the immunostimulatory effect of the formulation components (immunostimulants modulates the immune response elicited. Protective immunity against malaria requires the induction of humoral, antibody-dependent cellular inhibition (ADCI and effector and memory cell responses. This review summarizes the status of adjuvants that have been or are being employed in the malaria vaccine development, focusing on the pharmaceutical and immunological aspects, as well as on their immunization outcomings at clinical and preclinical stages.

  20. Malaria vaccine adjuvants: latest update and challenges in preclinical and clinical research.

    Science.gov (United States)

    Mata, Elena; Salvador, Aiala; Igartua, Manoli; Hernández, Rosa María; Pedraz, José Luis

    2013-01-01

    There is no malaria vaccine currently available, and the most advanced candidate has recently reported a modest 30% efficacy against clinical malaria. Although many efforts have been dedicated to achieve this goal, the research was mainly directed to identify antigenic targets. Nevertheless, the latest progresses on understanding how immune system works and the data recovered from vaccination studies have conferred to the vaccine formulation its deserved relevance. Additionally to the antigen nature, the manner in which it is presented (delivery adjuvants) as well as the immunostimulatory effect of the formulation components (immunostimulants) modulates the immune response elicited. Protective immunity against malaria requires the induction of humoral, antibody-dependent cellular inhibition (ADCI) and effector and memory cell responses. This review summarizes the status of adjuvants that have been or are being employed in the malaria vaccine development, focusing on the pharmaceutical and immunological aspects, as well as on their immunization outcomings at clinical and preclinical stages.

  1. The Large Synoptic Survey Telescope: A summary update on the scientific potential for pulsating star research

    Directory of Open Access Journals (Sweden)

    Graham Melissa L.

    2017-01-01

    Full Text Available The Large Synoptic Survey Telescope (LSST will provide hundreds of deep images of the southern sky over its 10 year duration, enabling variability studies for an unprecedentedly large and unbiased population of objects. In this proceeding paper I will cover the aspects of the LSST’s survey and data products that are most relevant to the study of stellar pulsations (Sect. 1, and provide a directory of pertinent materials for further information. I will also summarize the anticipated variable star sample sizes from the LSST, and highlight recent research from several members of the scientific community which evaluates the scientific potential of the LSST’s data products with respect to pulsating stars (Sect. 2.

  2. Ophthalmic applications of lipid-based drug nanocarriers: an update of research and patenting activity.

    Science.gov (United States)

    Pignatello, Rosario; Carbone, Claudia; Puglia, Carmelo; Offerta, Alessia; Bonina, Francesco P; Puglisi, Giovanni

    2015-01-01

    Ophthalmic diseases collect great attention by researchers and pharmaceutical technologists, since they can dramatically worsen the quality of life. Because of the limited duration of action on the eye surface, and anatomical/physiological barriers to drug penetration from it into the inner eye structures, conventional ocular formulations are generally unable to perform at their best. Nanotechnology approaches can represent a solution to improve the therapeutic efficiency, compliance and safety of ocular drugs. In this respect, lipid-based nanocarriers are among the most interesting systems. Their composition and production methods make them highly biocompatible and safe formulations. This review illustrates the developments achieved in ocular drug delivery using lipid-based nanocarriers, with a critical revision of recent scientific articles and filed patents.

  3. A comprehensive review on food waste anaerobic digestion: Research updates and tendencies.

    Science.gov (United States)

    Ren, Yuanyuan; Yu, Miao; Wu, Chuanfu; Wang, Qunhui; Gao, Ming; Huang, Qiqi; Liu, Yu

    2018-01-01

    Anaerobic digestion has been practically applied in agricultural and industrial waste treatment and recognized as an economical-effective way for food waste disposal. This paper presented an overview on the researches about anaerobic digestion of food waste. Technologies (e.g., pretreatment, co-digestion, inhibition and mitigation, anaerobic digestion systems, etc.) were introduced and evaluated on the basis of bibliometric analysis. Results indicated that ethanol and aerobic prefermentation were novel approaches to enhance substrates hydrolysis and methane yield. With the promotion of resource recovery, more attention should be paid to biorefinery technologies which can produce more useful products toward zero emissions. Furthermore, a technological route for food waste conversion based on anaerobic digestion was proposed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury.

    Science.gov (United States)

    Kim, Seung Hyun; Naisbitt, Dean J

    2016-01-01

    Drug-induced liver injury (DILI) is a major concern for public health, as well as for drug development in the pharmaceutical industry, since it can cause liver failure and lead to drug withdrawal from the market and black box warnings. Thus, it is important to identify biomarkers for early prediction to increase our understanding of mechanisms underlying DILI that will ultimately aid in the exploration of novel therapeutic strategies to prevent or manage DILI. DILI can be subdivided into 'intrinsic' and 'idiosyncratic' categories, although the validity of this classification remains controversial. Idiosyncratic DILI occurs in a minority of susceptible individuals with a prolonged latency, while intrinsic DILI results from drug-induced direct hepatotoxicity over the course of a few days. The rare occurrence of idiosyncratic DILI requires multicenter collaborative investigations and phenotype standardization. Recent progress in research on idiosyncratic DILI is based on key developments in 3 areas: (1) newly developed high-throughput genotyping across the whole genome allowing for the identification of genetic susceptibility markers, (2) new mechanistic concepts on the pathogenesis of DILI revealing a key role of drug-responsive T lymphocytes in the immunological response, and (3) broad multidisciplinary approaches using different platform "-omics" technologies that have identified novel biomarkers for the prediction of DILI. An association of a specific human leukocyte antigen (HLA) allele with DILI has been reported for several drugs. HLA-restricted T-cell immune responses have also been investigated using lymphocytes and T-cell clones isolated from patients. A microRNA, miR-122, has been discovered as a promising biomarker for the early prediction of DILI. In this review, we summarize recent advances in research on idiosyncratic DILI with an understanding of the key role of adaptive immune systems.

  5. Pharmacotherapy for opioid dependence in jails and prisons: research review update and future directions

    Directory of Open Access Journals (Sweden)

    Sharma A

    2016-04-01

    Full Text Available Anjalee Sharma,1 Kevin E O'Grady,1,2 Sharon M Kelly,1 Jan Gryczynski,1 Shannon Gwin Mitchell,1 Robert P Schwartz1 1Friends Research Institute, Baltimore, 2Department of Psychology, University of Maryland, College Park, MD, USA Purpose: The World Health Organization recommends the initiation of opioid agonists prior to release from incarceration to prevent relapse or overdose. Many countries in the world employ these strategies. This paper considers the evidence to support these recommendations and the factors that have slowed their adoption in the US. Methods: We reviewed randomized controlled trials (RCTs and longitudinal/observational studies that examine participant outcomes associated with the initiation or continuation of opioid agonists (methadone, buprenorphine or antagonists (naltrexone during incarceration. Papers were identified through a literature search of PubMed with an examination of their references and were included if they reported outcomes for methadone, buprenorphine, or naltrexone continued during incarceration or initiated prior to release in a correctional institution. Results: Fourteen studies were identified, including eight RCTs and six observational studies. One RCT found that patients treated with methadone who were continued on versus tapered off methadone during brief incarceration were more likely to return to treatment upon release. A second RCT found that the group starting methadone treatment in prison versus a waiting list was less likely to report using heroin and sharing syringes during incarceration. A third RCT found no differences in postrelease heroin use or reincarceration between individuals initiating treatment with methadone versus those initiating treatment with buprenorphine during relatively brief incarcerations. Findings from four additional RCTs indicate that starting opioid agonist treatment during incarceration versus after release was associated with higher rates of entry into community

  6. The South/Southeast Asia Research Initiative (SARI) Update and Meeting Objectives

    Science.gov (United States)

    Vadrevu, Krishna Prasad

    2017-01-01

    Land Use/Cover Change (LU/CC) is one of the most important types of environmental change in South and Southeast Asian countries. Several studies suggest that LU/CC in these countries is in large part driven by population growth and economic development. In the region, changes that are most common include urban expansion, agricultural land loss, land abandonment, deforestation, logging, reforestation, etc. To address the research needs and priorities in the region, a regional initiative entitled South Southeast Asia Regional Initiative (SARI) has been developed involving US and regional scientists. The initiative is funded by NASA Land Cover, Land Use Change program. The goal of SARI is to integrate state-of-the-art remote sensing, natural sciences, engineering and social sciences to enrich LU/CC science in South Southeast Asian countries. In the presentation, LU/CC change research in SARI countries will be highlighted including the drivers of change. For example, in South Asia, forest cover has been increasing in countries like India, Nepal and Bhutan due to sustainable afforestation measures; whereas, large-scale deforestation in Southeast Asian countries is still continuing, due to oil palm plantation expansion driven by the international market demand in Malaysia and Indonesia. With respect to urbanization, South and Southeast Asian countries contain 23 megacities, each with more than 10 million people. Rapid urbanization is driving agricultural land loss and agricultural intensification has been increasing due to less availability of land for growing food crops such as in India, Vietnam, and Thailand. The drivers of LUCC vary widely in the region and include such factors as land tenure, local economic development, government policies, inappropriate land management, land speculation, improved road networks, etc. In addition, variability in the weather, climate, and socioeconomic factors also drive LU/CC resulting in disruptions of biogeochemical cycles

  7. Updates on chemical and biological research on botanical ingredients in dietary supplements.

    Science.gov (United States)

    Pawar, Rahul S; Tamta, Hemlata; Ma, Jun; Krynitsky, Alexander J; Grundel, Erich; Wamer, Wayne G; Rader, Jeanne I

    2013-05-01

    Increased use of dietary supplements is a phenomenon observed worldwide. In the USA, more than 40% of the population recently reported using complementary and alternative medicines, including botanical dietary supplements. Perceptions that such dietary supplements are natural and safe, may prevent disease, may replace prescription medicines, or may make up for a poor diet, play important roles in their increased use. Toxicity of botanical dietary supplements may result from the presence of naturally occurring toxic constituents or from contamination or adulteration with pharmaceutical agents, heavy metals, mycotoxins, pesticides, or bacteria, misidentification of a plant species in a product, formation of electrophilic metabolites, organ-specific reactions, or botanical-drug interactions. The topics discussed in this review illustrate several issues in recent research on botanical ingredients in dietary supplements. These include (1) whether 1,3-dimethylamylamine is a natural constituent of rose geranium (Pelargonium graveolens), (2) how analysis of the components of dietary supplements containing bitter melon (Momordica charantia) is essential to understanding their potential biological effects, and (3) how evolving methods for in vitro studies on botanical ingredients can contribute to safety evaluations. The virtual explosion in the use of botanical ingredients in hundreds of products presents a considerable challenge to the analytical community, and the need for appropriate methods cannot be overstated. We review recent developments and use of newer and increasingly sensitive methods that can contribute to increasing the safety and quality of botanical ingredients in dietary supplements.

  8. Research Update: Electrical monitoring of cysts using organic electrochemical transistors a

    Science.gov (United States)

    Huerta, M.; Rivnay, J.; Ramuz, M.; Hama, A.; Owens, R. M.

    2015-03-01

    Organotypic three-dimensional (3D) cell culture models have the potential to act as surrogate tissues in vitro, both for basic research and for drug discovery/toxicology. 3D cultures maintain not only 3D architecture but also cell-cell and cell extracellular matrix interactions, particularly when grown in cysts or spheroids. Characterization of cell cultures grown in 3D formats, however, provides a significant challenge for cell biologists due to the incompatibility of these structures with commonly found optical or electronic monitoring systems. Electronic impedance spectroscopy is a cell culture monitoring technique with great potential; however, it has not been possible to integrate 3D cultures with commercially available systems to date. Cyst-like 3D cultures are particularly challenging due to their small size and difficulty in manipulation. Herein, we demonstrate isolation of cyst-like 3D cultures by capillarity and subsequent integration with the organic electrochemical transistor for monitoring the integrity of these structures. We show not only that this versatile device can be adapted to the cyst format for measuring resistance and, therefore, the quality of the cysts, but also can be used for quantitative monitoring of the effect of toxic compounds on cells in a 3D format. The ability to quantitatively predict effects of drugs on 3D cultures in vitro has large future potential for the fields of drug discovery and toxicology.

  9. Pharmacotherapy for opioid dependence in jails and prisons: research review update and future directions.

    Science.gov (United States)

    Sharma, Anjalee; O'Grady, Kevin E; Kelly, Sharon M; Gryczynski, Jan; Mitchell, Shannon Gwin; Schwartz, Robert P

    2016-01-01

    and relatively widespread in Europe are discussed. Recommendations for future research are outlined.

  10. Dietary interventions in children with autism spectrum disorders - an updated review of the research evidence.

    Science.gov (United States)

    Marti, Luis F

    2014-01-01

    Autism Spectrum Disorders (ASD) is a group of life-long neurodevelopmental disorders, with onset before 3 years of age. They are characterized by qualitative impairmentin social interactions, absent or impaired language and communication skills, and present with a wide range of stereotyped, repetitive behaviors. Function and outcome are affected not only by core deficits but by associated behaviors such as hyperactivity, aggression, anxiety, and depression. Increasing evidence indicates that autism is a complex, multifactorial disorder involving the brain and the body, a result of genetic vulnerabilities interacting with environmental factors. Although genetics plays a role, the fact, that the incidence of autism in identical twins is not 100% points to external or environmental factors as contributors. No etiology - based treatment has yet been developed. During the last two decades many educational, psychosocial and pharmacological interventions had been utilized and claimed to be effective and even "curative". The word treatment should be used with caution, and should stand for interventions that are aimed to help people with ASD to adjust more effectively to their environment. Many studies have indicated that behavioral therapy and medication may be at least partially helpful in the treatment of children with ASD particularly on the symptoms of aggression, hyperactivity and attention. In the light of an approved and well established treatment for ASD, over the past two decades research on the effect of diet and nutrition on autism has been increasing. Particular attention has focused on the role of food additives, refined sugar, food allergies, and fatty acid metabolism. However, the results are conflicting and not conclusive. We present here anupdated review summarizing the potentials and limits of the most frequent nutritional and dietary interventions in the treatment of Autism Spectrum Disorders.

  11. Neuropathic pain: an updated grading system for research and clinical practice

    Science.gov (United States)

    Finnerup, Nanna B.; Haroutounian, Simon; Kamerman, Peter; Baron, Ralf; Bennett, David L.H.; Bouhassira, Didier; Cruccu, Giorgio; Freeman, Roy; Hansson, Per; Nurmikko, Turo; Raja, Srinivasa N.; Rice, Andrew S.C.; Serra, Jordi; Smith, Blair H.; Treede, Rolf-Detlef; Jensen, Troels S.

    2016-01-01

    Abstract The redefinition of neuropathic pain as “pain arising as a direct consequence of a lesion or disease affecting the somatosensory system,” which was suggested by the International Association for the Study of Pain (IASP) Special Interest Group on Neuropathic Pain (NeuPSIG) in 2008, has been widely accepted. In contrast, the proposed grading system of possible, probable, and definite neuropathic pain from 2008 has been used to a lesser extent. Here, we report a citation analysis of the original NeuPSIG grading paper of 2008, followed by an analysis of its use by an expert panel and recommendations for an improved grading system. As of February, 2015, 608 eligible articles in Scopus cited the paper, 414 of which cited the neuropathic pain definition. Of 220 clinical studies citing the paper, 56 had used the grading system. The percentage using the grading system increased from 5% in 2009 to 30% in 2014. Obstacles to a wider use of the grading system were identified, including (1) questions about the relative significance of confirmatory tests, (2) the role of screening tools, and (3) uncertainties about what is considered a neuroanatomically plausible pain distribution. Here, we present a revised grading system with an adjusted order, better reflecting clinical practice, improvements in the specifications, and a word of caution that even the “definite” level of neuropathic pain does not always indicate causality. In addition, we add a table illustrating the area of pain and sensory abnormalities in common neuropathic pain conditions and propose areas for further research. PMID:27115670

  12. MEK Inhibitors Research Update

    Science.gov (United States)

    Drugs that block the MEK protein have shown promise in several cancers. Trametinib has had encouraging results in patients with advanced melanoma, and selumetinib has been tested in patients with advanced thyroid and ovarian cancers.

  13. Cookstove Research Update

    Science.gov (United States)

    This webinar includes the following topics: (1) Introduction and field activities, John Mitchell, (2) STAR (Science To Achieve Results) grants, Terry Keating, (3) LCA (life cycle assessment) report, (4) Mutagenicity study, David DeMarini, (5) Health effects study, Jan Dye, (6) IS...

  14. Update of X- and γ-ray decay data standards for detector calibration and other applications. Summary report of the second research co-ordination meeting

    International Nuclear Information System (INIS)

    Herman, M.; Nichols, A.L.

    2000-09-01

    The Second Research Co-ordination Meeting to Update X- and γ-ray Decay Data Standards for Detector Calibration was held at PTB Braunschweig from 10 to 12 May 2000. A primary aim of this meeting was to review progress in the evaluation and recommendation of data under the auspices of the CRP. All CRP activities were reviewed, and actions agreed for the remaining 18 months of the programme. Separate indexing was provided for 13 contributions to the meeting

  15. About the necessity to update the Radiological safety and protection regulations of the National Institute of Nuclear Research (ININ)

    International Nuclear Information System (INIS)

    Alvarez R, J.T.

    1997-01-01

    It is argued the necessity to update the Radiological safety and Protection regulations (Review 3) of ININ, with the purpose that it implements the ICRU operative magnitudes system. Such a system used with radiological protection purposes. The objective of this system is to do an estimation of the effective equivalent dose H E and/or the Effective dose E, proposed in the ICRP 26 and ICRU 60 dose limits systems respectively. (Author)

  16. Choosing important health outcomes for comparative effectiveness research: An updated systematic review and involvement of low and middle income countries

    Science.gov (United States)

    Davis, Katherine; Gorst, Sarah L.; Harman, Nicola; Smith, Valerie; Gargon, Elizabeth; Altman, Douglas G.; Blazeby, Jane M.; Clarke, Mike; Tunis, Sean; Williamson, Paula R.

    2018-01-01

    Background Core outcome sets (COS) comprise a minimum set of outcomes that should be measured and reported in all trials for a specific health condition. The COMET (Core Outcome Measures in Effectiveness Trials) Initiative maintains an up to date, publicly accessible online database of published and ongoing COS. An annual systematic review update is an important part of this process. Methods This review employed the same, multifaceted approach that was used in the original review and the previous two updates. This approach has identified studies that sought to determine which outcomes/domains to measure in clinical trials of a specific condition. This update includes an analysis of the inclusion of participants from low and middle income countries (LMICs) as identified by the OECD, in these COS. Results Eighteen publications, relating to 15 new studies describing the development of 15 COS, were eligible for inclusion in the review. Results show an increase in the use of mixed methods, including Delphi surveys. Clinical experts remain the most common stakeholder group involved. Overall, only 16% of the 259 COS studies published up to the end of 2016 have included participants from LMICs. Conclusion This review highlights opportunities for greater public participation in COS development and the involvement of stakeholders from a wider range of geographical settings, in particular LMICs. PMID:29438429

  17. Report on the inaugural meeting of the international consortium on hallucination research : a clinical and research update and 16 consensus-set goals for future research

    NARCIS (Netherlands)

    Waters, F.; Aleman, A.; Fernyhough, C.; Allen, P.

    This article presents a report on the first meeting of the International Consortium on Hallucination Research, which took place on September 13-14, 2011 at the Institute of Psychiatry, London. The first day of the meeting served to reflect on the current state of knowledge regarding auditory

  18. Circular Updates

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Circular Updates are periodic sequentially numbered instructions to debriefing staff and observers informing them of changes or additions to scientific and specimen...

  19. Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwifery 8 (2003) 148-154].

    Science.gov (United States)

    Chopin Lucks, Barbara

    2003-08-01

    The first trial of two essential oils (derived separately from leaf and fruit) of Vitex agnus castus for menopausal balance was conducted in the summer of 2000 by the author. Surveys completed by the 23 participants in that trial indicated strong symptomatic relief of common menopausal symptoms.(2) This research update details the result of the second round of trials, which were conducted in the summer of 2002 with 52 additional subjects under the supervision of 12 diverse health practitioners. The second trial appears to support the finding of the first trial, as well as identifying some important contraindications to use of the essential oil.

  20. Report on the consultants' meeting on preparation of the proposal for a coordinated research project to update X- and γ-ray decay data standards for detector calibration

    International Nuclear Information System (INIS)

    Nichols, A.; Herman, M.

    1998-05-01

    The IAEA Nuclear Data Section has been charged by the International Nuclear Data Committee to consider the establishment of a Coordinated Research Project (CRP) to update the IAEA database of X-ray and γ-ray Standards for Detector Calibration. This CRP should re-define the radionuclides most suited for detector calibration, extending applications to safeguards, materials analysis, environmental monitoring, and medical use. This document is a report on the Consultants' Meeting held at IAEA, Vienna, between 24-25 November 1997 to assess the current needs, re-define the most suitable radionuclides, and advise the IAEA Nuclear Data Section on the need and form of such a CRP

  1. Update of European bioethics

    DEFF Research Database (Denmark)

    Rendtorff, Jacob Dahl

    2015-01-01

    This paper presents an update of the research on European bioethics undertaken by the author together with Professor Peter Kemp since the 1990s, on Basic ethical principles in European bioethics and biolaw. In this European approach to basic ethical principles in bioethics and biolaw......, the principles of autonomy, dignity, integrity and vulnerability are proposed as the most important ethical principles for respect for the human person in biomedical and biotechnological development. This approach to bioethics and biolaw is presented here in a short updated version that integrates the earlier...... research in a presentation of the present understanding of the basic ethical principles in bioethics and biolaw....

  2. Breast Cancer and Estrogen-Alone Update

    Science.gov (United States)

    ... Current Issue Past Issues Research News From NIH Breast Cancer and Estrogen-Alone Update Past Issues / Summer 2006 ... hormone therapy does not increase the risk of breast cancer in postmenopausal women, according to an updated analysis ...

  3. CIHR Canadian HIV Trials Network Coinfection and Concurrent Diseases Core Research Group: 2016 Updated Canadian HIV/Hepatitis C Adult Guidelines for Management and Treatment

    Science.gov (United States)

    Hull, Mark; Wong, Alex; Tseng, Alice; Giguère, Pierre; Barrett, Lisa; Haider, Shariq; Conway, Brian; Klein, Marina; Cooper, Curtis

    2016-01-01

    Background. Hepatitis C virus (HCV) coinfection occurs in 20–30% of Canadians living with HIV and is responsible for a heavy burden of morbidity and mortality. Purpose. To update national standards for management of HCV-HIV coinfected adults in the Canadian context with evolving evidence for and accessibility of effective and tolerable DAA therapies. The document addresses patient workup and treatment preparation, antiviral recommendations overall and in specific populations, and drug-drug interactions. Methods. A standing working group with HIV-HCV expertise was convened by The Canadian Institute of Health Research HIV Trials Network to review recently published HCV antiviral data and update Canadian HIV-HCV Coinfection Guidelines. Results. The gap in sustained virologic response between HCV monoinfection and HIV-HCV coinfection has been eliminated with newer HCV antiviral regimens. All coinfected individuals should be assessed for interferon-free, Direct Acting Antiviral HCV therapy. Regimens vary in content, duration, and success based largely on genotype. Reimbursement restrictions forcing the use of pegylated interferon is not acceptable if optimal patient care is to be provided. Discussion. Recommendations may not supersede individual clinical judgement. Treatment advances published since December 2015 are not considered in this document. PMID:27471521

  4. Ethical and practical guidelines for reporting genetic research results to study participants: updated guidelines from a National Heart, Lung, and Blood Institute working group.

    Science.gov (United States)

    Fabsitz, Richard R; McGuire, Amy; Sharp, Richard R; Puggal, Mona; Beskow, Laura M; Biesecker, Leslie G; Bookman, Ebony; Burke, Wylie; Burchard, Esteban Gonzalez; Church, George; Clayton, Ellen Wright; Eckfeldt, John H; Fernandez, Conrad V; Fisher, Rebecca; Fullerton, Stephanie M; Gabriel, Stacey; Gachupin, Francine; James, Cynthia; Jarvik, Gail P; Kittles, Rick; Leib, Jennifer R; O'Donnell, Christopher; O'Rourke, P Pearl; Rodriguez, Laura Lyman; Schully, Sheri D; Shuldiner, Alan R; Sze, Rebecca K F; Thakuria, Joseph V; Wolf, Susan M; Burke, Gregory L

    2010-12-01

    In January 2009, the National Heart, Lung, and Blood Institute convened a 28-member multidisciplinary Working Group to update the recommendations of a 2004 National Heart, Lung, and Blood Institute Working Group focused on Guidelines to the Return of Genetic Research Results. Changes in the genetic and societal landscape over the intervening 5 years raise multiple questions and challenges. The group noted the complex issues arising from the fact that technological and bioinformatic progress has made it possible to obtain considerable information on individuals that would not have been possible a decade ago. Although unable to reach consensus on a number of issues, the working group produced 5 recommendations. The working group offers 2 recommendations addressing the criteria necessary to determine when genetic results should and may be returned to study participants, respectively. In addition, it suggests that a time limit be established to limit the duration of obligation of investigators to return genetic research results. The group recommends the creation of a central body, or bodies, to provide guidance on when genetic research results are associated with sufficient risk and have established clinical utility to justify their return to study participants. The final recommendation urges investigators to engage the broader community when dealing with identifiable communities to advise them on the return of aggregate and individual research results. Creation of an entity charged to provide guidance to institutional review boards, investigators, research institutions, and research sponsors would provide rigorous review of available data, promote standardization of study policies regarding return of genetic research results, and enable investigators and study participants to clarify and share expectations for the handling of this increasingly valuable information with appropriate respect for the rights and needs of participants.

  5. An Update on the Status of RR Lyrae Research - Report of the RRL2015 Meeting (October, Hungary) (Abstract)

    Science.gov (United States)

    Kolenberg, K.

    2016-06-01

    (Abstract only) In October 2015 we organized the first international meeting focused on RR Lyrae research, with the goal to discuss recent developments and future RR Lyrae plans. The Scientific rationale is the following:

  6. Updated standardized endpoint definitions for transcatheter aortic valve implantation: The Valve Academic Research Consortium-2 consensus document

    NARCIS (Netherlands)

    A.P. Kappetein (Arie Pieter); S.J. Head (Stuart); P. Généreux (Philippe); N. Piazza (Nicolo); N.M. van Mieghem (Nicolas); E.H. Blackstone (Eugene); T.G. Brott (Thomas); D.J. Cohen (David J.); D.E. Cutlip (Donald); G.A. van Es (Gerrit Anne); R.T. Hahn (Rebecca); A.J. Kirtane (Ajay); M. Krucoff (Mitchell); S. Kodali (Susheel); M.J. Mack (Michael); R. Mehran (Roxana); J. Rodés-Cabau (Josep); P. Vranckx (Pascal); J.G. Webb (John); S.W. Windecker (Stephan); P.W.J.C. Serruys (Patrick); M.B. Leon (Martin)

    2012-01-01

    textabstractObjectives: The aim of the current Valvular Academic Research Consortium (VARC)-2 initiative was to revisit the selection and definitions of transcatheter aortic valve implantation (TAVI)- clinical endpoints to make them more suitable to the present and future needs of clinical trials.

  7. The Joint Space Operations Center Mission System and the Advanced Research, Collaboration, and Application Development Environment Status Update 2016

    Science.gov (United States)

    Murray-Krezan, Jeremy; Howard, Samantha; Sabol, Chris; Kim, Richard; Echeverry, Juan

    2016-05-01

    The Joint Space Operations Center (JSpOC) Mission System (JMS) is a service-oriented architecture (SOA) infrastructure with increased process automation and improved tools to enhance Space Situational Awareness (SSA) performed at the US-led JSpOC. The Advanced Research, Collaboration, and Application Development Environment (ARCADE) is a test-bed maintained and operated by the Air Force to (1) serve as a centralized test-bed for all research and development activities related to JMS applications, including algorithm development, data source exposure, service orchestration, and software services, and provide developers reciprocal access to relevant tools and data to accelerate technology development, (2) allow the JMS program to communicate user capability priorities and requirements to developers, (3) provide the JMS program with access to state-of-the-art research, development, and computing capabilities, and (4) support JMS Program Office-led market research efforts by identifying outstanding performers that are available to shepherd into the formal transition process. In this paper we will share with the international remote sensing community some of the recent JMS and ARCADE developments that may contribute to greater SSA at the JSpOC in the future, and share technical areas still in great need.

  8. Muscles, Ligaments and Tendons Journal - Basic principles and recommendations in clinical and field Science Research: 2016 Update.

    Science.gov (United States)

    Padulo, Johnny; Oliva, Francesco; Frizziero, Antonio; Maffulli, Nicola

    2016-01-01

    The proper design and implementation of a study as well as a balanced and well-supported evaluation and interpretation of its main findings are of crucial importance when reporting and disseminating research. Also accountability, funding acknowledgement and adequately declaring any conflict of interest play a major role in science. Since the Muscles, Ligaments and Tendons Journal (MLTJ) is committed to the highest scientific and ethical standards, we encourage all Authors to take into account and to comply, as much as possible, to the contents and issues discussed in this official editorial. This could be useful for improving the quality of the manuscripts, as well as to stimulate interest and debate and to promote constructive change, reflecting upon uses and misuses within our disciplines belonging to the field of "Clinical and Sport - Science Research".

  9. Update: Health Status of Iranian Victims of Chemical Weapons / Ongoing Research Projects Addressing CW Health Effects in Iran

    International Nuclear Information System (INIS)

    Khateri, S.

    2007-01-01

    Use of chemical weapons against Iran during the 1980s was a horrifying epic in the annals of modern warfare, inflicting enormous suffering during the conflict that continues to the present day in the form of latent illness among survivors. Surviving victims suffer from a diverse range of chronic illnesses placing an enormous strain on the nation's medical infrastructure. To define the scope of this problem, the National Organization for Veteran's Affairs (Janbazan) established a subsidiary research department called Janbazan Medical and Engineering Research Center (JMERC). Beginning in 2000 JMERC has conducted epidemiological, clinical and basic scientific studies to characterize disease among chemical attack survivors and develop new therapeutic strategies. The primary JMERC mission has been to identify where resources may be allocated so as to most effectively treat patients with the greatest need - requiring a comprehensive picture of the major medical problems among this population. Accordingly, JMERC's initial task was to define the nature and distribution of serious chronic illness among CW survivors. Therefore epidemiological studies in CW-exposed Iranian populations are currently underway. Ultimately these studies will allow management of illness among CW-exposed populations that is both compassionate and cost-effective. A summary of the above mentioned research projects will be reported in this article. (author)

  10. Astrophysics Update 2

    CERN Document Server

    Mason, John W

    2006-01-01

    "Astrophysics Updates" is intended to serve the information needs of professional astronomers and postgraduate students about areas of astronomy, astrophysics and cosmology that are rich and active research spheres. Observational methods and the latest results of astronomical research are presented as well as their theoretical foundations and interrelations. The contributed commissioned articles are written by leading exponents in a format that will appeal to professional astronomers and astrophysicists who are interested in topics outside their own specific areas of research. This collection of timely reviews may also attract the interest of advanced amateur astronomers seeking scientifically rigorous coverage.

  11. Effectiveness of nutritional interventions on the functioning of children with ADHD and/or ASD. An updated review of research evidence.

    Science.gov (United States)

    Martí, Luis F

    2010-01-01

    Attention deficit - hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder of childhood and comprises a range of behavioral problems, including inattention, impulsivity and hyperactivity. ADHD has been investigated extensively during the last 30 years. At this point most researchers agree that ADHD is a problem of complex etiology that needs to be investigated as a function of complex interactions. Autism Spectrum Disorders (ASD) is a chronic disorder, with onset before three years of age. It is one of the fastest growing developmental disabilities in the United States and Puerto Rico. It presents with a wide range of stereotyped, repetitive behaviors, social and language impairment. Function and outcome is affected not only by core deficits but by associated behaviors such as hyperactivity, aggression, anxiety, and depression. Many studies have indicated that behavioral therapy and medication may be at least partially helpful in the treatment of children with ADHD or with ASD. Research on the effect of diet and nutrition on ADHD and autism has been increasing in the past two decades, particularly on the symptoms of hyperactivity and attention. Particular attention has focused on the role of food additives, refined sugar, food allergies, and fatty acid metabolism. It is imperative that data supporting new treatments should be scrutinized for scientific study design, clinical safety, and scientific validity, before embarking on them as modes of therapy. This updated review presents the evidence regarding the usefulness and limitations of the most frequent nutritional and dietary interventions in the treatment of ADHD and/or ASD.

  12. Closed-Cycle Hydrogen-Oxygen Regenerative Fuel Cell at the NASA Glenn Research Center-An Update

    Science.gov (United States)

    Bents, David J.; Chang, Bei-Jiann; Johnson, Donald W.; Garcia, Christopher P.

    2008-01-01

    The closed cycle hydrogen-oxygen proton exchange membrane (PEM) regenerative fuel cell (RFC) at the NASA Glenn Research Center has demonstrated multiple back-to-back contiguous cycles at rated power and round-trip efficiencies up to 52 percent. It is the first fully closed cycle RFC ever demonstrated. (The entire system is sealed; nothing enters or escapes the system other than electrical power and heat.) During fiscal year fiscal year (FY) FY06 to FY07, the system s numerous modifications and internal improvements focused on reducing parasitic power, heat loss, and noise signature; increasing its functionality as an unattended automated energy storage device; and in-service reliability.

  13. Muscles, Ligaments and Tendons Journal – Basic principles and recommendations in clinical and field Science Research: 2016 Update

    Science.gov (United States)

    Padulo, Johnny; Oliva, Francesco; Frizziero, Antonio; Maffulli, Nicola

    2016-01-01

    Summary The proper design and implementation of a study as well as a balanced and well-supported evaluation and interpretation of its main findings are of crucial importance when reporting and disseminating research. Also accountability, funding acknowledgement and adequately declaring any conflict of interest play a major role in science. Since the Muscles, Ligaments and Tendons Journal (MLTJ) is committed to the highest scientific and ethical standards, we encourage all Authors to take into account and to comply, as much as possible, to the contents and issues discussed in this official editorial. This could be useful for improving the quality of the manuscripts, as well as to stimulate interest and debate and to promote constructive change, reflecting upon uses and misuses within our disciplines belonging to the field of “Clinical and Sport - Science Research”. PMID:27331026

  14. Review: A neglected Flavivirus: an update on Zika virus in 2016 and the future direction of research.

    Science.gov (United States)

    Bharucha, Tehmina; Breuer, Judith

    2016-06-01

    The 2015-16 global emergence of Zika virus infection (ZIKV) and its link with Guillain-Barré Syndrome and microcephaly, at the tail-end of the Ebola epidemic, has provoked unease throughout the international community. The World Health Organisation declared ZIKV a public health emergency on 1st February 2016, but until the 31st March 2016 maintained that there was insufficient evidence that ZIKV was independently responsible for any serious complications. Our current understanding of this arthropod-borne flavivirus is still at an early stage. The first reported human infections were 60 years ago, and until the first outbreak in Micronesia in 2007, there were only 14 documented cases. Nonetheless, there are parallels that we can draw from our understanding of other related arbo-flaviviruses, such as dengue, Japanese encephalitis and West Nile viruses. This article provides a focussed review of the literature on ZIKV to date, with perspectives on the direction of future research. © 2016 British Neuropathological Society.

  15. [Update of the work of the ethics research in evaluating genetic research and its role as an external ethics committee biobank].

    Science.gov (United States)

    Alfonso Farnós, Iciar; Hernández Gil, Arantza; Rodríguez Velasco, María

    2013-01-01

    Research on human genome and its applications open great perspectives to improve human beings' health. However, these advances must never endanger the respect of dignity, freedom and rights of the participants in medical research, assuring prohibition of any way of discrimination because of genetic features. The Independent Research Boards (IRB), responsible for safeguarding rights, safety and well-being of the subjects taking part in the biomedical research, assess independently submitted genetic studies, clinical trials whose primary objective is obtaining genetic information and genetic sub-studies of clinical trials with drugs. Biobanks, as safeguarding means to preserve biological samples in suitable quality conditions, must be assigned to two external committees, a scientific one and an ethics one. External ethics committees of biobanks have to make the ethical assessment of the submissions of samples transfers and associated data, in order to carry out research projects. On the other hand, they have to advise biobanks on the compliance of ethical and legal principles, which, in many committees, has turned into the performance of informed consent forms which are in accordance with current laws.

  16. Public Interest Energy Research (PIER) Program. Final Project Report. California Energy Balance Update and Decomposition Analysis for the Industry and Building Sectors

    Energy Technology Data Exchange (ETDEWEB)

    de la Rue du Can, Stephane [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hasanbeigi, Ali [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sathaye, Jayant [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2010-12-01

    This report on the California Energy Balance version 2 (CALEB v2) database documents the latest update and improvements to CALEB version 1 (CALEB v1) and provides a complete picture of how energy is supplied and consumed in the State of California. The CALEB research team at Lawrence Berkeley National Laboratory (LBNL) performed the research and analysis described in this report. CALEB manages highly disaggregated data on energy supply, transformation, and end-use consumption for about 40 different energy commodities, from 1990 to 2008. This report describes in detail California's energy use from supply through end-use consumption as well as the data sources used. The report also analyzes trends in energy demand for the "Manufacturing" and "Building" sectors. Decomposition analysis of energy consumption combined with measures of the activity driving that consumption quantifies the effects of factors that shape energy consumption trends. The study finds that a decrease in energy intensity has had a very significant impact on reducing energy demand over the past 20 years. The largest impact can be observed in the industry sector where energy demand would have had increased by 358 trillion British thermal units (TBtu) if subsectoral energy intensities had remained at 1997 levels. Instead, energy demand actually decreased by 70 TBtu. In the "Building" sector, combined results from the "Service" and "Residential" subsectors suggest that energy demand would have increased by 264 TBtu (121 TBtu in the "Services" sector and 143 TBtu in the "Residential" sector) during the same period, 1997 to 2008. However, energy demand increased at a lesser rate, by only 162 TBtu (92 TBtu in the "Services" sector and 70 TBtu in the "Residential" sector). These energy intensity reductions can be indicative of energyefficiency improvements during the past 10 years. The research presented in this report provides a basis for developing an energy-efficiency performance index to measure

  17. Updated global soil map for the Weather Research and Forecasting model and soil moisture initialization for the Noah land surface model

    Science.gov (United States)

    DY, C. Y.; Fung, J. C. H.

    2016-08-01

    A meteorological model requires accurate initial conditions and boundary conditions to obtain realistic numerical weather predictions. The land surface controls the surface heat and moisture exchanges, which can be determined by the physical properties of the soil and soil state variables, subsequently exerting an effect on the boundary layer meteorology. The initial and boundary conditions of soil moisture are currently obtained via National Centers for Environmental Prediction FNL (Final) Operational Global Analysis data, which are collected operationally in 1° by 1° resolutions every 6 h. Another input to the model is the soil map generated by the Food and Agriculture Organization of the United Nations - United Nations Educational, Scientific and Cultural Organization (FAO-UNESCO) soil database, which combines several soil surveys from around the world. Both soil moisture from the FNL analysis data and the default soil map lack accuracy and feature coarse resolutions, particularly for certain areas of China. In this study, we update the global soil map with data from Beijing Normal University in 1 km by 1 km grids and propose an alternative method of soil moisture initialization. Simulations of the Weather Research and Forecasting model show that spinning-up the soil moisture improves near-surface temperature and relative humidity prediction using different types of soil moisture initialization. Explanations of that improvement and improvement of the planetary boundary layer height in performing process analysis are provided.

  18. An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium "Opportunities for Hydrocephalus Research: Pathways to Better Outcomes".

    Science.gov (United States)

    McAllister, James P; Williams, Michael A; Walker, Marion L; Kestle, John R W; Relkin, Norman R; Anderson, Amy M; Gross, Paul H; Browd, Samuel R

    2015-12-01

    Building on previous National Institutes of Health-sponsored symposia on hydrocephalus research, "Opportunities for Hydrocephalus Research: Pathways to Better Outcomes" was held in Seattle, Washington, July 9-11, 2012. Plenary sessions were organized into four major themes, each with two subtopics: Causes of Hydrocephalus (Genetics and Pathophysiological Modifications); Diagnosis of Hydrocephalus (Biomarkers and Neuroimaging); Treatment of Hydrocephalus (Bioengineering Advances and Surgical Treatments); and Outcome in Hydrocephalus (Neuropsychological and Neurological). International experts gave plenary talks, and extensive group discussions were held for each of the major themes. The conference emphasized patient-centered care and translational research, with the main objective to arrive at a consensus on priorities in hydrocephalus that have the potential to impact patient care in the next 5 years. The current state of hydrocephalus research and treatment was presented, and the following priorities for research were recommended for each theme. 1) Causes of Hydrocephalus-CSF absorption, production, and related drug therapies; pathogenesis of human hydrocephalus; improved animal and in vitro models of hydrocephalus; developmental and macromolecular transport mechanisms; biomechanical changes in hydrocephalus; and age-dependent mechanisms in the development of hydrocephalus. 2) Diagnosis of Hydrocephalus-implementation of a standardized set of protocols and a shared repository of technical information; prospective studies of multimodal techniques including MRI and CSF biomarkers to test potential pharmacological treatments; and quantitative and cost-effective CSF assessment techniques. 3) Treatment of Hydrocephalus-improved bioengineering efforts to reduce proximal catheter and overall shunt failure; external or implantable diagnostics and support for the biological infrastructure research that informs these efforts; and evidence-based surgical standardization with

  19. Models and applications for measuring the impact of health research: update of a systematic review for the Health Technology Assessment programme.

    Science.gov (United States)

    Raftery, James; Hanney, Steve; Greenhalgh, Trish; Glover, Matthew; Blatch-Jones, Amanda

    2016-10-01

    This report reviews approaches and tools for measuring the impact of research programmes, building on, and extending, a 2007 review. (1) To identify the range of theoretical models and empirical approaches for measuring the impact of health research programmes; (2) to develop a taxonomy of models and approaches; (3) to summarise the evidence on the application and use of these models; and (4) to evaluate the different options for the Health Technology Assessment (HTA) programme. We searched databases including Ovid MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature and The Cochrane Library from January 2005 to August 2014. This narrative systematic literature review comprised an update, extension and analysis/discussion. We systematically searched eight databases, supplemented by personal knowledge, in August 2014 through to March 2015. The literature on impact assessment has much expanded. The Payback Framework, with adaptations, remains the most widely used approach. It draws on different philosophical traditions, enhancing an underlying logic model with an interpretative case study element and attention to context. Besides the logic model, other ideal type approaches included constructionist, realist, critical and performative. Most models in practice drew pragmatically on elements of several ideal types. Monetisation of impact, an increasingly popular approach, shows a high return from research but relies heavily on assumptions about the extent to which health gains depend on research. Despite usually requiring systematic reviews before funding trials, the HTA programme does not routinely examine the impact of those trials on subsequent systematic reviews. The York/Patient-Centered Outcomes Research Institute and the Grading of Recommendations Assessment, Development and Evaluation toolkits provide ways of assessing such impact, but need to be evaluated. The literature, as reviewed here, provides very few instances of a randomised trial

  20. Twenty-fifth water reactor safety information meeting: Proceedings. Volume 1: Plenary sessions; Pressure vessel research; BWR strainer blockage and other generic safety issues; Environmentally assisted degradation of LWR components; Update on severe accident code improvements and applications

    International Nuclear Information System (INIS)

    Monteleone, S.

    1998-03-01

    This three-volume report contains papers presented at the conference. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from France, Japan, Norway, and Russia. The titles of the papers and the names of the authors have been updated and may differ from those that appeared in the final program of the meeting. This volume contains the following information: (1) plenary sessions; (2) pressure vessel research; (3) BWR strainer blockage and other generic safety issues; (4) environmentally assisted degradation of LWR components; and (5) update on severe accident code improvements and applications. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database

  1. Transit research update : March 2009.

    Science.gov (United States)

    SPECIAL............................................................................................................................3 : HUD and DOT Announce Interagency Partnership to Promote Sustainable Communities.......................................

  2. WIMS Library updating

    International Nuclear Information System (INIS)

    Ravnik, M.; Trkov, A.; Holubar, A.

    1992-01-01

    At the end of 1990 the WIMS Library Update Project (WLUP) has been initiated at the International Atomic Energy Agency. The project was organized as an international research project, coordinated at the J. Stefan Institute. Up to now, 22 laboratories from 19 countries joined the project. Phase 1 of the project, which included WIMS input optimization for five experimental benchmark lattices, has been completed. The work presented in this paper describes also the results of Phase 2 of the Project, in which the cross sections based on ENDF/B-IV evaluated nuclear data library have been processed. (author) [sl

  3. Fulbright update

    Science.gov (United States)

    Opportunities to teach or perform postdoctoral research in the earth and atmospheric sciences under the Senior Scholar Fulbright awards program for 1984-1985 (Eos, March 1, 1983, p. 81) are available in 14 countries, according to the Council for International Exchange of Scholars.The countries and the specialization opportunities are Algeria, any specialization; Australia, mineral processing research; India, any specialization in geology or geophysics; Israel, environmental studies; Korea, any specialization; Lebanon, geophysics, geotectonics, and structural geology; Morocco, research methods in science education; Pakistan, geology, marine biology, and mineralogy; Poland, mining technology; Sudan, geology and remote sensing; Thailand, planning and environmental change; USSR, any specialization; Yugoslavia, any research specialization; and Zimbabwe, exploration geophysics and solid earth geophysics.

  4. Late presentation for HIV care across Europe: update from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study, 2010 to 2013

    NARCIS (Netherlands)

    Mocroft, Amanda; Lundgren, Jens; Antinori, Andrea; Monforte, Antonella d'Arminio; Brännström, Johanna; Bonnet, Fabrice; Brockmeyer, Norbert; Casabona, Jordi; Castagna, Antonella; Costagliola, Dominique; de Wit, Stéphane; Fätkenheuer, Gerd; Furrer, Hansjakob; Jadand, Corinne; Johnson, Anne; Lazanas, Mario; Leport, Catherine; Moreno, Santiago; Mussini, Christina; Obel, Niels; Post, Frank; Reiss, Peter; Sabin, Caroline; Skaletz-Rorowski, Adriane; Suarez-Loano, Ignacio; Torti, Carlo; Warszawski, Josiane; Wittkop, Linda; Zangerle, Robert; Chene, Genevieve; Raben, Dorthe; Kirk, Ole; Touloumi, Giota; Meyer, Laurence; Dabis, François; Krause, Murielle Mary; Ghosn, Jade; Wit, Ferdinand; Prins, Maria; Bucher, Heiner; Gibb, Diana; del Amo, Julia; Thorne, Claire; Stephan, Christoph; Pérez-Hoyos, Santiago; Hamouda, Osamah; Bartmeyer, Barbara; Chkhartishvili, Nikoloz; Noguera-Julian, Antoni; D'Arminio Monforte, Antonella; Prieto, Luis; Conejo, Pablo Rojo; Soriano-Arandes, Antoni; Battegay, Manuel; Kouyos, Roger; Mussini, Cristina; Tookey, Pat; Miró, Jose M.; Konopnick, Deborah; Goetghebuer, Tessa; Sönnerborg, Anders; Teira, Ramon; Garrido, Myriam; Haerry, David; Chêne, Geneviève; Judd, Ali; Barger, Diana; Schwimmer, Christine; Termote, Monique; Campbell, Maria; Frederiksen, Casper M.; Friis-Moller, Nina; Kjaer, Jesper; Brandt, Rikke Salbøl; Berenguer, Juan; Bohlius, Julia; Bouteloup, Vincent; Cozzi-Lepri, Alessandro; Davies, Mary-Anne; Dorrucci, Maria; Dunn, David; Egger, Matthias; Guiguet, Marguerite; Grabar, Sophie; Lambotte, Olivier; Leroy, Valériane; Lodi, Sara; Matheron, Sophie; Monge, Susana; Nakagawa, Fumiyo; Paredes, Roger; Phillips, Andrew; Puoti, Massimo; Schomaker, Michael; Smit, Colette; Sterne, Jonathan; Thiebaut, Rodolphe; van der Valk, Marc; Wyss, Natasha

    2015-01-01

    Late presentation (LP) for HIV care across Europe remains a significant issue. We provide a cross-European update from 34 countries on the prevalence and risk factors of LP for 2010-2013. People aged >= 16 presenting for HIV care (earliest of HIV-diagnosis, first clinic visit or cohort enrolment)

  5. DUBNA: Update

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    Full text: At the annual session of the Plenipotentiaries Committee of the Joint Institute for Nuclear Research (JINR), Dubna, near Moscow in March, Institute Director Vladimir G. Kadyshevsky reported on important recent achievements. The Nuklotron superconducting accelerator has now been completed and is in operation. (A report will feature in a forthcoming edition of the CERN Courier.) The FOBOS multiple event spectrometer mounted in the heavy ion beam of the U-400M cyclotron is designed to record the products of nuclear reactions in the high mass and charge region with high efficiency. New experiments are envisaged. At the IBR research reactor a cryogenic moderator has been put into operation. Physics goals include generation of an impulse flux of cold neutrons. The neutron Fourier high resolution diffractometer was commissioned for polycrystal studies. Meanwhile an imaginative scheme to establish an International University using JINR research facilities and highly qualified personnel is being implemented. New appointments include Alexei Sissakian and Tzvetan Vylov as Vice-Directors, Nikolai Russakovitch as Chief Scientific Secretary, Vladislav Sarentzev as Chief Engineer and Alexandre Lebedev as Administrative Director. Western physicists elected members of JINR Scientific council include Ugo Amaldi and Lucien Montanet from CERN, Claude Detraz (IN2P3, Paris), Friedrich Dydak (Munich), Guido Piragino (Italy), George Trilling (Berkeley), Herwig Schopper (Germany) and Norbert Kroo (Hungary). Earlier this year saw the 80th birthday of Venedikt Dzhelepov, Honorary Director of JINR's Laboratory of Nuclear Problems

  6. Updating systematic reviews: an international survey.

    Directory of Open Access Journals (Sweden)

    Chantelle Garritty

    a formal written policy for updating SRs. This research marks the first baseline data available on updating from an organizational perspective.

  7. Late presentation for HIV care across Europe: update from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study, 2010 to 2013

    OpenAIRE

    Hamouda, Osamah; Gunsenheimer-Bartmeyer, Barbara

    2015-01-01

    Late presentation (LP) for HIV care across Europe remains a significant issue. We provide a cross-European update from 34 countries on the prevalence and risk factors of LP for 2010–2013. People aged ≥ 16 presenting for HIV care (earliest of HIV-diagnosis, first clinic visit or cohort enrolment) after 1 January 2010 with available CD4 count within six months of presentation were included. LP was defined as presentation with a CD4 count 

  8. Hispanic update.

    Science.gov (United States)

    Haub, C

    1987-11-01

    The Hispanic population of the US grew from 14.6 million at the time of the 1980 Census to 18.8 million by March 1987 -- a 30% growth -- according to the Current Population Survey (CPS). This rate of growth was 5 times that of the non-Hispanic population. These new estimates incorporate an allowance for estimated illegal immigration since 1980, which adds 141,000 persons to the Hispanic population each year. Yet, this increase is offset by an annual emigration estimate of 31,000, which now is being used. The net effect is to add 110,000 more Hispanics each year, a figure which accounts for 18% of US population growth since 1980. The CPS showed that about 1/4 of Hispanic families were below the 1986 poverty level and that overall their median income was about 1/3 less than the income of non-Hispanic families -- $19,995 in contrast to $30,231. There was no income increase for the Hispanic population since 1981. Both Cubans and Puerto Ricans have shown a decrease since 1985 in the CPS estimates. The Census Bureau will be conducting research to determine the possible causes of the decrease.

  9. Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee.

    Science.gov (United States)

    Rossini, P M; Burke, D; Chen, R; Cohen, L G; Daskalakis, Z; Di Iorio, R; Di Lazzaro, V; Ferreri, F; Fitzgerald, P B; George, M S; Hallett, M; Lefaucheur, J P; Langguth, B; Matsumoto, H; Miniussi, C; Nitsche, M A; Pascual-Leone, A; Paulus, W; Rossi, S; Rothwell, J C; Siebner, H R; Ugawa, Y; Walsh, V; Ziemann, U

    2015-06-01

    These guidelines provide an up-date of previous IFCN report on "Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application" (Rossini et al., 1994). A new Committee, composed of international experts, some of whom were in the panel of the 1994 "Report", was selected to produce a current state-of-the-art review of non-invasive stimulation both for clinical application and research in neuroscience. Since 1994, the international scientific community has seen a rapid increase in non-invasive brain stimulation in studying cognition, brain-behavior relationship and pathophysiology of various neurologic and psychiatric disorders. New paradigms of stimulation and new techniques have been developed. Furthermore, a large number of studies and clinical trials have demonstrated potential therapeutic applications of non-invasive brain stimulation, especially for TMS. Recent guidelines can be found in the literature covering specific aspects of non-invasive brain stimulation, such as safety (Rossi et al., 2009), methodology (Groppa et al., 2012) and therapeutic applications (Lefaucheur et al., 2014). This up-dated review covers theoretical, physiological and practical aspects of non-invasive stimulation of brain, spinal cord, nerve roots and peripheral nerves in the light of more updated knowledge, and include some recent extensions and developments. Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  10. Updates in ophthalmic pathology.

    Science.gov (United States)

    Mendoza, Pia R; Grossniklaus, Hans E

    2017-05-01

    Ophthalmic pathology has a long history and rich heritage in the field of ophthalmology. This review article highlights updates in ophthalmic pathology that have developed significantly through the years because of the efforts of committed individuals and the confluence of technology such as molecular biology and digital pathology. This is an exciting period in the history of ocular pathology, with cutting-edge techniques paving the way for new developments in diagnostics, therapeutics, and research. Collaborations between ocular oncologists and pathologists allow for improved and comprehensive patient care. Ophthalmic pathology continues to be a relevant specialty that is important in the understanding and clinical management of ocular disease, education of eye care providers, and overall advancement of the field.

  11. Updates in ophthalmic pathology

    Directory of Open Access Journals (Sweden)

    Pia R Mendoza

    2017-01-01

    Full Text Available Ophthalmic pathology has a long history and rich heritage in the field of ophthalmology. This review article highlights updates in ophthalmic pathology that have developed significantly through the years because of the efforts of committed individuals and the confluence of technology such as molecular biology and digital pathology. This is an exciting period in the history of ocular pathology, with cutting-edge techniques paving the way for new developments in diagnostics, therapeutics, and research. Collaborations between ocular oncologists and pathologists allow for improved and comprehensive patient care. Ophthalmic pathology continues to be a relevant specialty that is important in the understanding and clinical management of ocular disease, education of eye care providers, and overall advancement of the field.

  12. Cohort Profile Update

    DEFF Research Database (Denmark)

    Omland, Lars Haukali; Ahlström, Magnus Glindvad; Obel, Niels

    2014-01-01

    of Causes of Death, the Danish National Prescription Registry, the Attainment Register and the Integrated Database for Labour Market Research to get information on vital status, migration, cancer, hospital contacts, causes of death, dispensed prescriptions, education and employment. Using this design, rates......The DHCS is a cohort of all HIV-infected individuals seen in one of the eight Danish HIV centres after 31 December 1994. Here we update the 2009 cohort profile emphasizing the development of the cohort. Every 12-24 months, DHCS is linked with the Danish Civil Registration System (CRS) in order...... to extract an age- and sex-matched comparison cohort from the general population, as well as cohorts of family members of the HIV-infected patients and of the comparison cohort. The combined cohort is linked with CRS, the Danish Cancer Registry, the Danish National Hospital Registry, the Danish Registry...

  13. ADAS Update and Maintainability

    Science.gov (United States)

    Watson, Leela R.

    2010-01-01

    Since 2000, both the National Weather Service Melbourne (NWS MLB) and the Spaceflight Meteorology Group (SMG) have used a local data integration system (LOIS) as part of their forecast and warning operations. The original LOIS was developed by the Applied Meteorology Unit (AMU) in 1998 (Manobianco and Case 1998) and has undergone subsequent improvements. Each has benefited from three-dimensional (3-D) analyses that are delivered to forecasters every 15 minutes across the peninsula of Florida. The intent is to generate products that enhance short-range weather forecasts issued in support of NWS MLB and SMG operational requirements within East Central Florida. The current LDIS uses the Advanced Regional Prediction System (ARPS) Data Analysis System (AD AS) package as its core, which integrates a wide variety of national, regional, and local observational data sets. It assimilates all available real-time data within its domain and is run at a finer spatial and temporal resolution than current national or regional-scale analysis packages. As such, it provides local forecasters with a more comprehensive understanding of evolving fine-scale weather features. Over the years, the LDIS has become problematic to maintain since it depends on AMU-developed shell scripts that were written for an earlier version of the ADAS software. The goals of this task were to update the NWS MLB/SMG LDIS with the latest version of ADAS, incorporate new sources of observational data, and upgrade and modify the AMU-developed shell scripts written to govern the system. In addition, the previously developed ADAS graphical user interface (GUI) was updated. Operationally, these upgrades will result in more accurate depictions of the current local environment to help with short-range weather forecasting applications, while also offering an improved initialization for local versions of the Weather Research and Forecasting (WRF) model used by both groups.

  14. Oil sands development update

    International Nuclear Information System (INIS)

    1999-01-01

    A detailed review and update of oil sands development in Alberta are provided covering every aspect of the production and economic aspects of the industry. It is pointed out that at present oil sands account for 28 per cent of Canadian crude oil production, expected to reach 50 per cent by 2005. Based on recent announcements, a total of 26 billion dollars worth of projects are in progress or planned; 20 billion dollars worth of this development is in the Athabasca area, the remainder in Cold Lake and other areas. The current update envisages up to 1,800,000 barrels per day by 2008, creating 47,000 new jobs and total government revenues through direct and indirect taxes of 118 billion dollars. Provinces other than Alberta also benefit from these development, since 60 per cent of all employment and income created by oil sands production is in other parts of Canada. Up to 60 per cent of the expansion is for goods and services and of this, 50 to 55 per cent will be purchased from Canadian sources. The remaining 40 per cent of the new investment is for engineering and construction of which 95 per cent is Canadian content. Aboriginal workforce by common consent of existing operators matches regional representation (about 13 per cent), and new developers are expected to match these standards. Planned or ongoing development in environmental protection through improved technologies and optimization, energy efficiency and improved tailings management, and active support of flexibility mechanisms such as emission credits trading, joint implementation and carbon sinks are very high on the industry's agenda. The importance of offsets are discussed extensively along with key considerations for international negotiations, as well as further research of other options such as sequestration, environmentally benign disposal of waste, and enhanced voluntary action

  15. Cannabis and Psychopathology : Update 2004

    OpenAIRE

    Grover, Sandeep; Basu, Debasish

    2004-01-01

    The study of cannabis use and psychopathology remains an interesting area from both academic and pragmatic perspectives. This article provides an update on the progress made in this area over the past decade or so. Psychopathology and psychiatric syndromes associated with cannabis use that have received research attention in recent years include cannabis withdrawal, cannabis and psychotic disorders (especially schizophrenia), depression, anxiety, and cognitive impairment. Status of a specific...

  16. Profile updating for information systems

    International Nuclear Information System (INIS)

    Abrantes, J.F.

    1983-02-01

    Profiles updating methods were analysed. A method suitable to the characteristics of the system used in the research (SDI/CIN/CNEN) that uses as the selection criterio the threshold and weights criterion, was determined. Relevance weighting theory was described and experiments to verify precision were carried out. The improvements obtained were good nevertheless more significant tests are required to attain more reliable results. (Author) [pt

  17. An Update on Memory Reconsolidation Updating.

    Science.gov (United States)

    Lee, Jonathan L C; Nader, Karim; Schiller, Daniela

    2017-07-01

    The reactivation of a stored memory in the brain can make the memory transiently labile. During the time it takes for the memory to restabilize (reconsolidate) the memory can either be reduced by an amnesic agent or enhanced by memory enhancers. The change in memory expression is related to changes in the brain correlates of long-term memory. Many have suggested that such retrieval-induced plasticity is ideally placed to enable memories to be updated with new information. This hypothesis has been tested experimentally, with a translational perspective, by attempts to update maladaptive memories to reduce their problematic impact. We review here progress on reconsolidation updating studies, highlighting their translational exploitation and addressing recent challenges to the reconsolidation field. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Dali server update.

    Science.gov (United States)

    Holm, Liisa; Laakso, Laura M

    2016-07-08

    The Dali server (http://ekhidna2.biocenter.helsinki.fi/dali) is a network service for comparing protein structures in 3D. In favourable cases, comparing 3D structures may reveal biologically interesting similarities that are not detectable by comparing sequences. The Dali server has been running in various places for over 20 years and is used routinely by crystallographers on newly solved structures. The latest update of the server provides enhanced analytics for the study of sequence and structure conservation. The server performs three types of structure comparisons: (i) Protein Data Bank (PDB) search compares one query structure against those in the PDB and returns a list of similar structures; (ii) pairwise comparison compares one query structure against a list of structures specified by the user; and (iii) all against all structure comparison returns a structural similarity matrix, a dendrogram and a multidimensional scaling projection of a set of structures specified by the user. Structural superimpositions are visualized using the Java-free WebGL viewer PV. The structural alignment view is enhanced by sequence similarity searches against Uniprot. The combined structure-sequence alignment information is compressed to a stack of aligned sequence logos. In the stack, each structure is structurally aligned to the query protein and represented by a sequence logo. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  19. Alternative energies. Updates on progress

    International Nuclear Information System (INIS)

    Ferreira, German

    2013-01-01

    Presents fundamental and applied research of alternative energies. Address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress. Includes the life cycle assessment and thermoeconomic analysis as tools for evaluating and optimising environmental and cost subjects. This book presents nine chapters based on fundamental and applied research of alternative energies. At the present time, the challenge is that technology has to come up with solutions that can provide environmentally friendly energy supply options that are able to cover the current world energy demand. Experts around the world are working on these issues for providing new solutions that will break the existing technological barriers. This book aims to address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress for each pillar. It also includes the life cycle assessment (LCA) and thermoeconomic analysis (TA) as tools for evaluating and optimising environmental and cost subjects. Chapters are organized into fundamental research, applied research and future trends; and written for engineers, academic researches and scientists.

  20. Alternative energies. Updates on progress

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, German (ed.) [CIRCE - Centre of Research for Energy Resources and Consumption, Zaragoza (Spain)

    2013-07-01

    Presents fundamental and applied research of alternative energies. Address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress. Includes the life cycle assessment and thermoeconomic analysis as tools for evaluating and optimising environmental and cost subjects. This book presents nine chapters based on fundamental and applied research of alternative energies. At the present time, the challenge is that technology has to come up with solutions that can provide environmentally friendly energy supply options that are able to cover the current world energy demand. Experts around the world are working on these issues for providing new solutions that will break the existing technological barriers. This book aims to address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress for each pillar. It also includes the life cycle assessment (LCA) and thermoeconomic analysis (TA) as tools for evaluating and optimising environmental and cost subjects. Chapters are organized into fundamental research, applied research and future trends; and written for engineers, academic researches and scientists.

  1. Late presentation for HIV care across Europe: update from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study, 2010 to 2013.

    Science.gov (United States)

    Mocroft, Amanda; Lundgren, Jens; Antinori, Andrea; Monforte, Antonella d'Arminio; Brännström, Johanna; Bonnet, Fabrice; Brockmeyer, Norbert; Casabona, Jordi; Castagna, Antonella; Costagliola, Dominique; De Wit, Stéphane; Fätkenheuer, Gerd; Furrer, Hansjakob; Jadand, Corinne; Johnson, Anne; Lazanas, Mario; Leport, Catherine; Moreno, Santiago; Mussini, Christina; Obel, Niels; Post, Frank; Reiss, Peter; Sabin, Caroline; Skaletz-Rorowski, Adriane; Suarez-Loano, Ignacio; Torti, Carlo; Warszawski, Josiane; Wittkop, Linda; Zangerle, Robert; Chene, Genevieve; Raben, Dorthe; Kirk, Ole

    2015-01-01

    Late presentation (LP) for HIV care across Europe remains a significant issue. We provide a cross-European update from 34 countries on the prevalence and risk factors of LP for 2010-2013. People aged ≥ 16 presenting for HIV care (earliest of HIV-diagnosis, first clinic visit or cohort enrollment) after 1 January 2010 with available CD4 count within six months of presentation were included. LP was defined as presentation with a CD4 count defining event (at any CD4), in the six months following HIV diagnosis. Logistic regression investigated changes in LP over time. A total of 30,454 people were included. The median CD4 count at presentation was 368/mm(3) (interquartile range (IQR) 193-555/mm(3)), with no change over time (p = 0.70). In 2010, 4,775/10,766 (47.5%) were LP whereas in 2013, 1,642/3,375 (48.7%) were LP (p = 0.63). LP was most common in central Europe (4,791/9,625, 49.8%), followed by northern (5,704/11,692; 48.8%), southern (3,550/7,760; 45.8%) and eastern Europe (541/1,377; 38.3%; p < 0.0001). There was a significant increase in LP in male and female people who inject drugs (PWID) (adjusted odds ratio (aOR)/year later 1.16; 95% confidence interval (CI): 1.02-1.32), and a significant decline in LP in northern Europe (aOR/year later 0.89; 95% CI: 0.85-0.94). Further improvements in effective HIV testing strategies, with a focus on vulnerable groups, are required across the European continent.

  2. Screening and Brief Interventions: Research Update. Prevention Update

    Science.gov (United States)

    Higher Education Center for Alcohol, Drug Abuse, and Violence Prevention, 2012

    2012-01-01

    Developed in 1993 at the University of Washington, Brief Alcohol Screening and Intervention for College Students (BASICS) is a preventive intervention program to reduce drinking and enhance awareness about alcohol-related issues. BASICS targets college students who are considered at risk because of heavy drinking behaviors. The brief intervention…

  3. Red Hill Updates

    Science.gov (United States)

    This and other periodic updates are intended to keep the public informed on major progress being made to protect public health and the environment at the Red Hill Underground Fuel Storage Facility in Hawaii.

  4. Invasive Species Science Update (No. 6)

    Science.gov (United States)

    Paula Fornwalt

    2013-01-01

    The sixth issue of the Rocky Mountain Research Station's (RMRS) Invasive Species Science Update is now complete. Published approximately once per year, this newsletter keeps managers and other users up-to-date with recently completed and ongoing research by RMRS scientists, and covers breaking news related to invasive species issues. The newsletter is produced by...

  5. A systematic review of management strategies for children's mental health care in the emergency department: update on evidence and recommendations for clinical practice and research.

    Science.gov (United States)

    Newton, Amanda S; Hartling, Lisa; Soleimani, Amir; Kirkland, Scott; Dyson, Michele P; Cappelli, Mario

    2017-06-01

    Children with mental health crises require access to specialised resources and services which are not yet standard in general and paediatric EDs. In 2010, we published a systematic review that provided some evidence to support the use of specialised care models to reduce hospitalisation, return ED visits and length of ED stay. We perform a systematic review to update the evidence base and inform current policy statements. Twelve databases and the grey literature were searched up to January 2015. Seven studies were included in the review (four newly identified studies). These studies compared ED-based strategies designed to assess, treat and/or therapeutically support or manage a mental health presentation. The methodological quality of six studies was assessed using the Cochrane Effective Practice and Organization of Care Risk of Bias tool (one interrupted time series study) and a modified Newcastle-Ottawa Scale (three retrospective cohort and two before-after studies). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was applied to rate overall evidence quality (high, moderate, low or very low) for individual outcomes from these six studies. An additional study evaluated the psychometric properties of a clinical instrument and was assessed using criteria developed by the Society of Pediatric Psychology Assessment Task Force (well-established, approaching well-established or promising assessment). There is low to very low overall evidence quality that: (1) use of screening laboratory tests to medically clear mental health patients increases length of ED stay and costs, but does not increase the risk of clinical management or disposition change if not conducted; and (2) specialised models of ED care reduce lengths of ED stay, security man-hours and restraint orders. One mental health assessment tool of promising quality, the home, education, activities and peers, drugs and alcohol, suicidality, emotions and behaviour, discharge

  6. Advances and Directions for the Intelligent Systems for Geosciences Research Community: Updates and Opportunities from the NSF EarthCube IS-GEO RCN

    Science.gov (United States)

    Pierce, S. A.

    2017-12-01

    The Earthcube Intelligent Systems for Geosciences Research Collaboration Network (IS-GEO RCN) represents an emerging community of interdisciplinary researchers aiming to create fundamental new capabilities for understanding Earth systems. Collaborative efforts across IS-GEO fields of study offer opportunities to accelerate scientific discovery and understanding. The IS-GEO community has an active membership of approximately 65 researchers and includes researchers from across the US, international members, and an early career committee. Current working groups are open to new participants and are focused on four thematic areas with regular coordination meetings and upcoming sessions at professional conferences. (1) The Sensor-based data Collection and Integration Working group looks at techniques for analyzing and integrating of information from heterogeneous sources, with a possible application for early warning systems. (2) The Geoscience Case Studies Working group is creating benchmark data sets to enable new collaborations between geoscientists and data scientists. (3) The Geo-Simulations Working group is evaluating the state of the art in practices for parametrizations, scales, and model integration. (4) The Education Working group is gathering, organizing and collecting all the materials from the different IS-GEO courses. Innovative IS-GEO applications will help researchers overcome common challenges while will redefining the frontiers of discovery across fields and disciplines. (Visit IS-GEO.org for more information or to sign up for any of the working groups.)

  7. Los Alamos Climatology 2016 Update

    Energy Technology Data Exchange (ETDEWEB)

    Bruggeman, David Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-02-10

    The Los Alamos National Laboratory (LANL or the Laboratory) operates a meteorology monitoring network to support LANL emergency response, engineering designs, environmental compliance, environmental assessments, safety evaluations, weather forecasting, environmental monitoring, research programs, and environmental restoration. Weather data has been collected in Los Alamos since 1910. Bowen (1990) provided climate statistics (temperature and precipitation) for the 1961– 1990 averaging period, and included other analyses (e.g., wind and relative humidity) based on the available station locations and time periods. This report provides an update to the 1990 publication Los Alamos Climatology (Bowen 1990).

  8. The European Organization for Research and Treatment of Cancer approach to developing questionnaire modules: an update and overview. EORTC Quality of Life Study Group

    NARCIS (Netherlands)

    Sprangers, M. A.; Cull, A.; Groenvold, M.; Bjordal, K.; Blazeby, J.; Aaronson, N. K.

    1998-01-01

    The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Study Group has adopted a modular approach to quality of life (QoL) assessment in cancer clinical trials. The core instrument (the EORTC QLQ-C30) covers a range of QoL issues relevant to a broad spectrum of

  9. News at Biochemia Medica: research integrity corner, updated guidelines to authors, revised author statement form and adopted ICMJE Conflict-of-Interest Form.

    Science.gov (United States)

    Simundic, Ana-Maria

    2013-01-01

    From the issue 23(1) we have implemented several major changes in the editorial policies and procedures. We hope that those changes will raise awareness of our potential authors and reviewers for research and publication integrity issues as well as to improve the quality of our submissions and published articles. Among those changes is the launch of a special journal section called Research Integrity Corner. In this section we aim to publish educational articles dealing with different research and publication misconduct issues. Moreover, we have done a comprehensive revision of our Instructions to authors. Whereas our former Instructions to authors have mostly been concerned with recommendations for manuscript preparation and submission, the revised document additionally describes the editorial procedure for all submitted articles and provides exact journal policies towards research integrity, authorship, copyright and conflict of interest. By putting these Guidelines into action, we hope that our main ethical policies and requirements are now visible and available to all our potential authors. We have also revised the former Authorship and copyright form which is now called the Author statement form. This form now contains statements on the authorship, originality of work, research ethics, patient privacy and confidentiality, and copyright transfer. Finally, Journal has adopted the ICMJE Form for Disclosure of Potential Conflicts of Interest. From this issue, for each submitted article, authors are requested to fill out the "ICMJE Form for Disclosure of Potential Conflicts of Interest" as well as the Author statement form and upload those forms during the online manuscript submission process. We honestly believe that our authors and readers will appreciate such endeavors. In this Editorial article we briefly explain the background and the nature of those recent major editorial changes.

  10. Early Limits on the Verbal Updating of an Object's Location

    Science.gov (United States)

    Ganea, Patricia A.; Harris, Paul L.

    2013-01-01

    Recent research has shown that by 30 months of age, children can successfully update their representation of an absent object's location on the basis of new verbal information, whereas 23-month-olds often return to the object's prior location. The current results show that this updating failure persisted even when (a) toddlers received visual and…

  11. Updating action domain descriptions.

    Science.gov (United States)

    Eiter, Thomas; Erdem, Esra; Fink, Michael; Senko, Ján

    2010-10-01

    Incorporating new information into a knowledge base is an important problem which has been widely investigated. In this paper, we study this problem in a formal framework for reasoning about actions and change. In this framework, action domains are described in an action language whose semantics is based on the notion of causality. Unlike the formalisms considered in the related work, this language allows straightforward representation of non-deterministic effects and indirect effects of (possibly concurrent) actions, as well as state constraints; therefore, the updates can be more general than elementary statements. The expressivity of this formalism allows us to study the update of an action domain description with a more general approach compared to related work. First of all, we consider the update of an action description with respect to further criteria, for instance, by ensuring that the updated description entails some observations, assertions, or general domain properties that constitute further constraints that are not expressible in an action description in general. Moreover, our framework allows us to discriminate amongst alternative updates of action domain descriptions and to single out a most preferable one, based on a given preference relation possibly dependent on the specified criteria. We study semantic and computational aspects of the update problem, and establish basic properties of updates as well as a decomposition theorem that gives rise to a divide and conquer approach to updating action descriptions under certain conditions. Furthermore, we study the computational complexity of decision problems around computing solutions, both for the generic setting and for two particular preference relations, viz. set-inclusion and weight-based preference. While deciding the existence of solutions and recognizing solutions are PSPACE-complete problems in general, the problems fall back into the polynomial hierarchy under restrictions on the additional

  12. BI-RADS update.

    Science.gov (United States)

    Mercado, Cecilia L

    2014-05-01

    The updated American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) has been newly released. This article summarizes the changes and updates that have been made to BI-RADS. The goal of the revised edition continues to be the same: to improve clarification in image interpretation, maintain reporting standardization, and simplify the monitoring of outcomes. The new BI-RADS also introduces new terminology to provide a more universal lexicon across all 3 imaging modalities. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. 2014 Update of the Canadian Rheumatology Association/spondyloarthritis research consortium of Canada treatment recommendations for the management of spondyloarthritis. Part I: principles of the management of spondyloarthritis in Canada.

    Science.gov (United States)

    Rohekar, Sherry; Chan, Jon; Tse, Shirley M L; Haroon, Nigil; Chandran, Vinod; Bessette, Louis; Mosher, Dianne; Flanagan, Cathy; Keen, Kevin J; Adams, Karen; Mallinson, Michael; Thorne, Carter; Rahman, Proton; Gladman, Dafna D; Inman, Robert D

    2015-04-01

    The Canadian Rheumatology Association (CRA) and the Spondyloarthritis Research Consortium of Canada (SPARCC) have collaborated to update the recommendations for the management of spondyloarthritis (SpA). A working group was assembled and consisted of the SPARCC executive committee, rheumatologist leaders from SPARCC collaborating sites, Canadian rheumatologists from across the country with an interest in SpA (both academic and community), a rheumatology trainee with an interest in SpA, an epidemiologist/health services researcher, a member of the CRA executive, a member of the CRA therapeutics committee, and a patient representative from the Canadian Spondylitis Association. An extensive review was conducted of literature published from 2007 to 2014 involving the management of SpA. The working group created draft recommendations using multiple rounds of Web-based surveys and an in-person conference. A survey was sent to the membership of the CRA to obtain an extended review that was used to finalize the recommendations. Guidelines for the management of SpA were created. Part I focuses on the principles of management of SpA in Canada and includes 6 general management principles, 5 ethical considerations, target groups for treatment recommendations, 2 wait time recommendations, and recommendations for disease monitoring. Also included are 6 modifications for application to juvenile SpA. These recommendations were developed based on current literature and applied to a Canadian healthcare context. It is hoped that the implementation of these recommendations will promote best practices in the treatment of SpA.

  14. Transportation and Aging: An Updated Research Agenda to Advance Safe Mobility among Older Adults Transitioning From Driving to Non-driving.

    Science.gov (United States)

    Dickerson, Anne E; Molnar, Lisa J; Bédard, Michel; Eby, David W; Berg-Weger, Marla; Choi, Moon; Grigg, Jenai; Horowitz, Amy; Meuser, Thomas; Myers, Anita; O'Connor, Melissa; Silverstein, Nina M

    2017-07-29

    Engagement in civic, social, and community life plays an important role in health, well-being, and quality of life, and requires individuals to be mobile in their environment. In this article, we review what is currently known about 2 areas relevant to safe mobility for older drivers and identify future research in these areas. Using a framework for transportation and safe mobility, 2 key areas were selected for review: the process of transitioning to non-driving and the maintenance of mobility after driving has ceased. This article serves as a companion to another article that used the same approach to explore safe mobility issues for older adults who are still driving. We found that although there has been progress in supporting transitioning process to non-driving and improving mobility options for older adults following driving cessation, many knowledge gaps still exist. We identified several research topics that would benefit from continued scientific inquiry. In addition, several themes emerged from the review, including the need for: multidisciplinary, community-wide solutions; large-scale, longitudinal studies; improved education and training for older adults and the variety of stakeholders involved in older adult transportation; and the need for programs and interventions that are flexible and responsive to individual needs and situational differences. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  15. Internet Journal of Medical Update - EJOURNAL

    African Journals Online (AJOL)

    Internet Journal of Medical Update (IJMU) is an international e-journal which provides a multidisciplinary forum for the exchange of current ideas in form of review articles, original research work, interesting case reports, etc. among medical professionals. Editorial policy: The Editor receives manuscripts with the ...

  16. Invasive Species Science Update (No. 1)

    Science.gov (United States)

    Mee-Sook Kim; Jack Butler

    2008-01-01

    This electronic newsletter (Invasive Species Science Update) is published by the Rocky Mountain Research Station (RMRS) Cross-Program, Interdisciplinary Project team on Invasive Species. This newsletter will be published 3 times per year and is intended to enhance communication among RMRS scientists, wildland managers, other partners, stakeholders, and customers about...

  17. Invasive Species Science Update (No. 7)

    Science.gov (United States)

    Dean Pearson; Yvette Ortega; Jack Butler

    2014-01-01

    Invasive Species Science Updates are designed to keep managers and other users up-to-date with recently completed and ongoing research by RMRS scientists, as well as highlight breaking news related to invasive species issues. The newsletter is produced by the RMRS Invasive Species Working Group (ISWG), which is a core group of scientists who volunteer to coordinate...

  18. Invasive Species Science Update (No. 5)

    Science.gov (United States)

    Dean Pearson; Yvette Ortega

    2011-01-01

    Welcome to the fifth issue of the Rocky Mountain Research Station's (RMRS) Invasive Species Science Update. The newsletter is produced by the RMRS Invasive Species Working Group (ISWG), which is a core group of scientists who volunteer to coordinate outreach of RMRS invasive species science to managers and the public. After publishing the past four newsletters, we...

  19. Invasive Species Science Update (No. 8)

    Science.gov (United States)

    Dean Pearson; Yvette Ortega; Jack Butler

    2015-01-01

    Invasive Species Science Updates are designed to keep managers and other users up-to-date with recently completed and ongoing research by RMRS scientists, as well as highlight breaking news related to invasive species issues. The newsletter is produced by the RMRS Invasive Species Working Group (ISWG), which is a core group of scientists who volunteer to coordinate...

  20. [WWW.2CHEAT.COM] Update

    Science.gov (United States)

    Rooks, Clay D.

    2006-01-01

    This paper is an updated presentation on the subject of cheating and plagiarism via the World Wide Web. In a few hours searching the Internet, the author found even more "cheat" sites than in 1998 that offered not only all types of term and research papers, but college admission letters, reviews, case studies, even dissertations as well. Most now…

  1. An update to the Surface Ocean CO

    NARCIS (Netherlands)

    Bakker, D.C.E.; de Baar, H.J.W.; van heuven, S.

    2014-01-01

    The Surface Ocean CO2 Atlas (SOCAT), an activity of the international marine carbon research community, provides access to synthesis and gridded fCO2 (fugacity of carbon dioxide) products for the surface oceans. Version 2 of SOCAT is an update of the previous release (version

  2. Supreme Court Update

    Science.gov (United States)

    Taylor, Kelley R.

    2009-01-01

    "Chief Justice Flubs Oath." "Justice Ginsburg Has Cancer Surgery." At the start of this year, those were the news headlines about the U.S. Supreme Court. But January 2009 also brought news about key education cases--one resolved and two others on the docket--of which school administrators should take particular note. The Supreme Court updates on…

  3. Update: Biological Nitrogen Fixation.

    Science.gov (United States)

    Wiseman, Alan; And Others

    1985-01-01

    Updates knowledge on nitrogen fixation, indicating that investigation of free-living nitrogen-fixing organisms is proving useful in understanding bacterial partners and is expected to lead to development of more effective symbioses. Specific areas considered include biochemistry/genetics, synthesis control, proteins and enzymes, symbiotic systems,…

  4. Liver transplantation : an update

    NARCIS (Netherlands)

    Verdonk, R. C.; Van den Berg, A. P.; Slooff, M. J. H.; Porte, R. J.; Haagsma, E. B.

    2007-01-01

    Liver transplantation has been an accepted treatment for end-stage liver disease since the 1980s. Currently it is a highly successful treatment for this indication. The aim of this review is to give a general update on recent developments in the field of liver transplantation. In the last decades

  5. Phaeochromocytoma – an update

    African Journals Online (AJOL)

    but has been advocated as the test of choice in many studies. The management of a phaeochromocytoma is mainly surgical and requires careful patient preparation to avoid catecholamine-induced complications during surgery. This review provides an update on phaeochromocytomas. Genetics. 68. J e. MDS a. November ...

  6. Updating protocols prodigy.

    Science.gov (United States)

    Ambrose, Kate

    2005-04-01

    If you are updating protocols, why not try the Prodigy website, at www.prodigy.nhs.uk ? It is a source of clinical knowledge on a range oftopics that is based on best evidence and organised to support clinical decision making.

  7. Update of telephone exchange

    CERN Multimedia

    2006-01-01

    As part of the upgrade of telephone services, the CERN switching centre will be updated on Monday 3 July between 8.00 p.m. and 3.00 a.m. Telephone services may be disrupted and possibly even interrupted during this operation.We apologise in advance for any inconvenience this may cause. CERN TELECOM Service

  8. Update of telephone exchange

    CERN Multimedia

    2006-01-01

    As part of the upgrade of telephone services, the CERN switching centre will be updated on between Monday 23 October 8.00 p.m. and Tuesday 24 October 2.00 a.m. Telephone services may be disrupted and possibly even interrupted during this operation. We apologise in advance for any inconvenience this may cause. CERN TELECOM Service

  9. Update of telephone exchange

    CERN Multimedia

    2006-01-01

    As part of the upgrade of telephone services, the CERN switching centre will be updated on Monday 3 July between 8.00 p.m. and 3.00 a.m. Telephone services may be disrupted and possibly even interrupted during this operation. We apologise in advance for any inconvenience this may cause. CERN TELECOM Service

  10. Update of telephone exchange

    CERN Multimedia

    2006-01-01

    As part of the upgrade of telephone services, the CERN switching centre will be updated on Wednesday 14 June between 8.00 p.m. and midnight. Telephone services may be disrupted and possibly even interrupted during this operation. We apologise in advance for any inconvenience this may cause. CERN TELECOM Service

  11. Update on the Methodological Quality of Research Published in The American Journal of Sports Medicine: Comparing 2011-2013 to 10 and 20 Years Prior.

    Science.gov (United States)

    Brophy, Robert H; Kluck, Dylan; Marx, Robert G

    2016-05-01

    In recent years, the number of articles in The American Journal of Sports Medicine (AJSM) has risen dramatically, with an increasing emphasis on evidence-based medicine in orthopaedics and sports medicine. Despite the increase in the number of articles published in AJSM over the past decade, the methodological quality of articles in 2011-2013 has improved relative to those in 2001-2003 and 1991-1993. Meta-analysis. All articles published in AJSM during 2011-2013 were reviewed and classified by study design. For each article, the use of pertinent methodologies, such as prospective data collection, randomization, control groups, and blinding, was recorded. The frequency of each article type and the use of evidence-based techniques were compared relative to 1991-1993 and 2001-2003 by use of Pearson χ(2) testing. The number of research articles published in AJSM more than doubled from 402 in 1991-1993 and 423 in 2001-2003 to 953 in 2011-2013. Case reports decreased from 15.2% to 10.6% to 2.1% of articles published over the study period (P < .001). Cadaveric/human studies and meta-analysis/literature review studies increased from 5.7% to 7.1% to 12.4% (P < .001) and from 0.2% to 0.9% to 2.3% (P = .01), respectively. Randomized, prospective clinical trials increased from 2.7% to 5.9% to 7.4% (P = .007). Fewer studies used retrospective compared with prospective data collection (P < .001). More studies tested an explicit hypothesis (P < .001) and used controls (P < .001), randomization (P < .001), and blinding of those assessing outcomes (P < .001). Multi-investigator trials increased (P < .001), as did the proportion of articles citing a funding source (P < .001). Despite a dramatic increase in the number of published articles, the research published in AJSM shifted toward more prospective, randomized, controlled, and blinded designs during 2011-2013 compared with 2001-2003 and 1991-1993, demonstrating a continued improvement in methodological quality. © 2015 The

  12. Methodological update in Medicina Intensiva.

    Science.gov (United States)

    García Garmendia, J L

    2018-04-01

    Research in the critically ill is complex by the heterogeneity of patients, the difficulties to achieve representative sample sizes and the number of variables simultaneously involved. However, the quantity and quality of records is high as well as the relevance of the variables used, such as survival. The methodological tools have evolved to offering new perspectives and analysis models that allow extracting relevant information from the data that accompanies the critically ill patient. The need for training in methodology and interpretation of results is an important challenge for the intensivists who wish to be updated on the research developments and clinical advances in Intensive Medicine. Copyright © 2017 Elsevier España, S.L.U. y SEMNIM. All rights reserved.

  13. The economic importance of acaricides in the control of phytophagous mites and an update on recent acaricide mode of action research.

    Science.gov (United States)

    Van Leeuwen, Thomas; Tirry, Luc; Yamamoto, Atsushi; Nauen, Ralf; Dermauw, Wannes

    2015-06-01

    Acaricides are one of the cornerstones of an efficient control program for phytophagous mites. An analysis of the global acaricide market reveals that spider mites such as Tetranychus urticae, Panonychus citri and Panonychus ulmi are by far the most economically important species, representing more than 80% of the market. Other relevant mite groups are false spider mites (mainly Brevipalpus), rust and gall mites and tarsonemid mites. Acaricides are most frequently used in vegetables and fruits (74% of the market), including grape vines and citrus. However, their use is increasing in major crops where spider mites are becoming more important, such as soybean, cotton and corn. As revealed by a detailed case study of the Japanese market, major shifts in acaricide use are partially driven by resistance development and the commercial availability of compounds with novel mode of action. The importance of the latter cannot be underestimated, although some compounds are successfully used for more than 30 years. A review of recent developments in mode of action research is presented, as such knowledge is important for devising resistance management programs. This includes spirocyclic keto-enols as inhibitors of acetyl-CoA carboxylase, the carbazate bifenazate as a mitochondrial complex III inhibitor, a novel class of complex II inhibitors, and the mite growth inhibitors hexythiazox, clofentezine and etoxazole that interact with chitin synthase I. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. 78 FR 9743 - Advisory Committee for Environmental Research and Education; Notice of Meeting

    Science.gov (United States)

    2013-02-11

    ... NATIONAL SCIENCE FOUNDATION Advisory Committee for Environmental Research and Education; Notice of... concerning support for environmental research and education. Agenda March 13, 2013 Update on NSF environmental research and education activities Update on national and international collaborations Update on...

  15. Sequence History Update Tool

    Science.gov (United States)

    Khanampompan, Teerapat; Gladden, Roy; Fisher, Forest; DelGuercio, Chris

    2008-01-01

    The Sequence History Update Tool performs Web-based sequence statistics archiving for Mars Reconnaissance Orbiter (MRO). Using a single UNIX command, the software takes advantage of sequencing conventions to automatically extract the needed statistics from multiple files. This information is then used to populate a PHP database, which is then seamlessly formatted into a dynamic Web page. This tool replaces a previous tedious and error-prone process of manually editing HTML code to construct a Web-based table. Because the tool manages all of the statistics gathering and file delivery to and from multiple data sources spread across multiple servers, there is also a considerable time and effort savings. With the use of The Sequence History Update Tool what previously took minutes is now done in less than 30 seconds, and now provides a more accurate archival record of the sequence commanding for MRO.

  16. Net Zero Water Update

    Science.gov (United States)

    2011-05-12

    Update 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7...Opened to Collect Supplemental Data from Candidate Installations 15 Mar 11 Supplemental Data received from Army Commands 16-31 Mar 11 DOE...hierarchy (reduction, re-purpose, recycling & composting , energy recovery, and disposal) • Complied with Net Zero definitions • Demonstrated

  17. Ontario Hydro's DSP update

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    Ontario Hydro's Demand/Supply Plan (DSP), the 25 year plan which was submitted in December 1989, is currently being reviewed by the Environmental Assessment Board (EAB). Since 1989 there have been several changes which have led Ontario Hydro to update the original Demand/Supply Plan. This information sheet gives a quick overview of what has changed and how Ontario Hydro is adapting to that change

  18. Strategies for Successful Aging: A Research Update

    Science.gov (United States)

    Depp, Colin A.; Harmell, Alexandrea L.; Jeste, Dilip

    2014-01-01

    Population aging is an enormous public health issue and there is clear need for strategies to maximize opportunities for successful aging. Many psychiatric illnesses are increasingly thought to be associated with accelerated aging, therefore emerging data on individual and policy level interventions that alter typical aging trajectories are relevant to mental health practitioners. Although the determinants and definition of successful aging remain controversial, increasing data indicate that psychiatric illnesses directly impact biological aging trajectories and diminish lifestyle, psychological and socio-environmental factors that seem reduce risk of morbidity and mortality. Many interventions designed to enhance the normal course of aging may be adjunctive approaches to management of psychiatric illnesses. We highlight recent data on interventions seeking to promote healthy aging, such as cognitive remediation, physical activity, nutrition, and complementary and alternative treatments for older people with and without psychiatric illnesses. PMID:25135776

  19. Avian Disease & Oncology Lab (ADOL) Research Update

    Science.gov (United States)

    Employing Genomics, Epigenetics, and Immunogenetics to Control Diseases Induced by Avian Tumor Viruses - Gene expression is a major factor accounting for phenotypic variation. Taking advantage of allele-specific expression (ASE) screens, we found the use of genetic markers was superior to traditiona...

  20. Research Update: Luminescence in lead halide perovskites

    Directory of Open Access Journals (Sweden)

    Ajay Ram Srimath Kandada

    2016-09-01

    Full Text Available Efficiency and dynamics of radiative recombination of carriers are crucial figures of merit for optoelectronic materials. Following the recent success of lead halide perovskites in efficient photovoltaic and light emitting technologies, here we review some of the noted literature on the luminescence of this emerging class of materials. After outlining the theoretical formalism that is currently used to explain the carrier recombination dynamics, we review a few significant works which use photoluminescence as a tool to understand and optimize the operation of perovskite based optoelectronic devices.

  1. Research Update: Luminescence in lead halide perovskites

    Science.gov (United States)

    Srimath Kandada, Ajay Ram; Petrozza, Annamaria

    2016-09-01

    Efficiency and dynamics of radiative recombination of carriers are crucial figures of merit for optoelectronic materials. Following the recent success of lead halide perovskites in efficient photovoltaic and light emitting technologies, here we review some of the noted literature on the luminescence of this emerging class of materials. After outlining the theoretical formalism that is currently used to explain the carrier recombination dynamics, we review a few significant works which use photoluminescence as a tool to understand and optimize the operation of perovskite based optoelectronic devices.

  2. Update on abusive head trauma.

    Science.gov (United States)

    Shaahinfar, Ashkon; Whitelaw, Kevin D; Mansour, Karim M

    2015-06-01

    This article provides an update on abusive head trauma (AHT), focusing on new developments most salient to the emergency medicine clinician, including epidemiology, clinical recognition, diagnostic work-up, management of neurologic injury, and public health implications. The recent literature has focused on honing the clinician's ability to recognize AHT and its immediate sequelae, to more accurately distinguish between abusive and accidental head injuries by patterns of neuroimaging and retinal hemorrhages, and to appreciate the long-term impacts. Specifically, both a clinical prediction rule and biomarker show promise, and new research advocates for the early identification of subclinical seizures as well as cervical spine injuries. The emergency medicine provider must be able to recognize and manage children who may have AHT and to appreciate when the diagnostic findings warrant consultation with a child protection team. These authors summarize the recent and notable advances in our understanding of AHT.

  3. Perancangan Sistem Otomatis Update Pada Aplikasi Desktop Abios

    Directory of Open Access Journals (Sweden)

    Karto Iskandar

    2010-12-01

    Full Text Available Unlike web applications easier to update the latest version, desktop applications more difficult and must involve the user in doing so. It is caused by a desktop application is an application that is installed in the computer user. The purpose of this research is to design an automatic system updates on a desktop application, an example case: Application Binus International Operational Support (ABIOS. This research used literature study and system design. In desktop applications, often there is update the latest applications that are not known to the user who sometimes fatal and disrupt business operations. Generally, developer will inform the changes version to user that they can update the application. In an update of applications, should be done by the system automatically, not manually by users. Once in a while, the user background is not from computer base. After doing the research, it can be concluded that the system automatically updates the application has benefits to users in obtaining information regarding the latest version, and can assist in automatically update the latest application is based on computerization. For further development of this system is expected to operate on multi platforms and or mobile applications. 

  4. Web Browser Security Update Effectiveness

    Science.gov (United States)

    Duebendorfer, Thomas; Frei, Stefan

    We analyze the effectiveness of different Web browser update mechanisms on various operating systems; from Google Chrome's silent update mechanism to Opera's update requiring a full re-installation. We use anonymized logs from Google's world wide distributed Web servers. An analysis of the logged HTTP user-agent strings that Web browsers report when requesting any Web page is used to measure the daily browser version shares in active use. To the best of our knowledge, this is the first global scale measurement of Web browser update effectiveness comparing four different Web browser update strategies including Google Chrome. Our measurements prove that silent updates and little dependency on the underlying operating system are most effective to get users of Web browsers to surf the Web with the latest browser version.

  5. Radiotherapy: An Update

    Directory of Open Access Journals (Sweden)

    Vikrant Kasat

    2010-01-01

    Full Text Available Radiotherapy is the art of using ionizing radiation to destroy malignant cells while minimizing damage to normal tissue. Radiotherapy has become a standard treatment option for a wide range of malignancies. Several new imaging techniques, both anatomical and functional are currently being evaluated as well as practiced for treatment planning of cancer. These recent developments have allowed radiation oncologists to escalate the dose of radiation delivered to tumors while minimizing the dose delivered to surrounding normal tissue. In this update, we attempt to pen down important aspects of radiotherapy.

  6. Hypokalemia: a clinical update

    Directory of Open Access Journals (Sweden)

    Efstratios Kardalas

    2018-04-01

    Full Text Available Hypokalemia is a common electrolyte disturbance, especially in hospitalized patients. It can have various causes, including endocrine ones. Sometimes, hypokalemia requires urgent medical attention. The aim of this review is to present updated information regarding: (1 the definition and prevalence of hypokalemia, (2 the physiology of potassium homeostasis, (3 the various causes leading to hypokalemia, (4 the diagnostic steps for the assessment of hypokalemia and (5 the appropriate treatment of hypokalemia depending on the cause. Practical algorithms for the optimal diagnostic, treatment and follow-up strategy are presented, while an individualized approach is emphasized.

  7. Context updates are hierarchical

    Directory of Open Access Journals (Sweden)

    Anton Karl Ingason

    2016-10-01

    Full Text Available This squib studies the order in which elements are added to the shared context of interlocutors in a conversation. It focuses on context updates within one hierarchical structure and argues that structurally higher elements are entered into the context before lower elements, even if the structurally higher elements are pronounced after the lower elements. The crucial data are drawn from a comparison of relative clauses in two head-initial languages, English and Icelandic, and two head-final languages, Korean and Japanese. The findings have consequences for any theory of a dynamic semantics.

  8. ASDSO updates bibliography, creates support database

    International Nuclear Information System (INIS)

    Spragens, L.

    1993-01-01

    The Association of State Dam Safety Officials has updated its Bibliography of Dam Safety Practices, originally published in 1990 with assistance from the US Committee on Large Dams. The new document lists publications addressing dam safety issues and includes 20 subject headings. The Federal Emergency Management Agency underwrote the update, which includes information about journal articles on dam safety, conference presentations, and new books and manuals. The publication also contains information about obtaining copies of the documents. The bibliography features a new section on use of geosynthetics in dam safety, compiled by Greg Hammer, of ASDSO's Technical Committee. Dam break analysis, emergency action planning, instrumentation, inspections, overtopping of dams, rehabilitation of dams, risk analysis, and seismic behavior are also included. In conjunction with the release of the updated bibliography, ASDSO is creating a computer database for its members that contains information from the bibliography. ASDSO also is in the process of adding information to the database about current research in dam safety. When the database becomes available later this year, members will be able to search for information on research in a specific subject area. Users also will be able to search for research groups, individuals, and universities to obtain an overview of who is conducting research in dam safety. Additionally, the database will allow the user to search for subject matter experts when looking for conference speakers and writers with specific specialties

  9. Preconditioner Updates Applied to CFD Model Problems

    Czech Academy of Sciences Publication Activity Database

    Birken, P.; Duintjer Tebbens, Jurjen; Meister, A.; Tůma, Miroslav

    2008-01-01

    Roč. 58, č. 11 (2008), s. 1628-1641 ISSN 0168-9274 R&D Projects: GA AV ČR 1ET400300415; GA AV ČR KJB100300703 Institutional research plan: CEZ:AV0Z10300504 Keywords : finite volume methods * update preconditioning * Krylov subspace methods * Euler equations * conservation laws Subject RIV: BA - General Mathematics Impact factor: 0.952, year: 2008

  10. Research Areas: Liver Disease

    Science.gov (United States)

    ... to their families, health professionals, and the public. Research Updates and News NIH study sheds light on ... findings to health professionals and the public. Support Research NIDDK invests in basic, clinical and translational research ...

  11. Effect of asynchronous updating on the stability of cellular automata

    International Nuclear Information System (INIS)

    Baetens, J.M.; Van der Weeën, P.; De Baets, B.

    2012-01-01

    Highlights: ► An upper bound on the Lyapunov exponent of asynchronously updated CA is established. ► The employed update method has repercussions on the stability of CAs. ► A decision on the employed update method should be taken with care. ► Substantial discrepancies arise between synchronously and asynchronously updated CA. ► Discrepancies between different asynchronous update schemes are less pronounced. - Abstract: Although cellular automata (CAs) were conceptualized as utter discrete mathematical models in which the states of all their spatial entities are updated simultaneously at every consecutive time step, i.e. synchronously, various CA-based models that rely on so-called asynchronous update methods have been constructed in order to overcome the limitations that are tied up with the classical way of evolving CAs. So far, only a few researchers have addressed the consequences of this way of updating on the evolved spatio-temporal patterns, and the reachable stationary states. In this paper, we exploit Lyapunov exponents to determine to what extent the stability of the rules within a family of totalistic CAs is affected by the underlying update method. For that purpose, we derive an upper bound on the maximum Lyapunov exponent of asynchronously iterated CAs, and show its validity, after which we present a comparative study between the Lyapunov exponents obtained for five different update methods, namely one synchronous method and four well-established asynchronous methods. It is found that the stability of CAs is seriously affected if one of the latter methods is employed, whereas the discrepancies arising between the different asynchronous methods are far less pronounced and, finally, we discuss the repercussions of our findings on the development of CA-based models.

  12. Research

    African Journals Online (AJOL)

    abp

    2015-09-09

    Sep 9, 2015 ... Orthopaedics and Traumatology, Faculty of Medicine, Adiyaman University, 02040 Adiyaman, Turkey,3Department of Orthopedics and. Traumatology, Umraniye Research and Education Hospital, 34899 Istanbul, Turkey, 4Department of Orthopedics and Traumatology, Umraniye. Research and Education ...

  13. Memory Updating and Mental Arithmetic.

    Science.gov (United States)

    Han, Cheng-Ching; Yang, Tsung-Han; Lin, Chia-Yuan; Yen, Nai-Shing

    2016-01-01

    Is domain-general memory updating ability predictive of calculation skills or are such skills better predicted by the capacity for updating specifically numerical information? Here, we used multidigit mental multiplication (MMM) as a measure for calculating skill as this operation requires the accurate maintenance and updating of information in addition to skills needed for arithmetic more generally. In Experiment 1, we found that only individual differences with regard to a task updating numerical information following addition (MUcalc) could predict the performance of MMM, perhaps owing to common elements between the task and MMM. In Experiment 2, new updating tasks were designed to clarify this: a spatial updating task with no numbers, a numerical task with no calculation, and a word task. The results showed that both MUcalc and the spatial task were able to predict the performance of MMM but only with the more difficult problems, while other updating tasks did not predict performance. It is concluded that relevant processes involved in updating the contents of working memory support mental arithmetic in adults.

  14. Memory updating and mental arithmetic

    Directory of Open Access Journals (Sweden)

    Cheng-Ching eHan

    2016-02-01

    Full Text Available Is domain-general memory updating ability predictive of calculation skills or are such skills better predicted by the capacity for updating specifically numerical information? Here, we used multidigit mental multiplication (MMM as a measure for calculating skill as this operation requires the accurate maintenance and updating of information in addition to skills needed for arithmetic more generally. In Experiment 1, we found that only individual differences with regard to a task updating numerical information following addition (MUcalc could predict the performance of MMM, perhaps owing to common elements between the task and MMM. In Experiment 2, new updating tasks were designed to clarify this: a spatial updating task with no numbers, a numerical task with no calculation, and a word task. The results showed that both MUcalc and the spatial task were able to predict the performance of MMM but only with the more difficult problems, while other updating tasks did not predict performance. It is concluded that relevant processes involved in updating the contents of working memory support mental arithmetic in adults.

  15. Research

    African Journals Online (AJOL)

    The research methodology module was reviewed as part of the overall revision of the undergraduate physiotherapy curriculum of ... Structuring the research methodology module using an EBP teaching framework prepares students to formulate a research question, effectively ... manage, and organise bibliographic citations.

  16. Research

    African Journals Online (AJOL)

    ebutamanya

    2015-05-13

    May 13, 2015 ... Systems (SEEDS)-INDEPTH Network Accra, Ghana, 3KEMRI/Wellcome Trust Research Programme, The Centre of Geographical Medicine Research-. Coast, Kilifi, Kenya, 4Population Health Sciences/Research Support Unit, Faculty of Health Sciences, Aga Khan University- East Africa, Nairobi,. Kenya ...

  17. Research

    African Journals Online (AJOL)

    research process, as part of which students must find and appraise evidence from research.[5] This highlights that teaching research methodology is inclined towards equipping students ... Students believed that evidence-based practice was vital, yet their understanding of the concept was restricted when compared with the.

  18. Research

    African Journals Online (AJOL)

    ebutamanya

    2015-03-02

    Mar 2, 2015 ... this program provided short-term and long-term research training to. US infectious disease fellows who would work on collaborative research projects with Kenyan trainees. Since the program began in. 1988, there have been 56 US trainees, and 13 of these continue to collaborate with Kenyan researchers.

  19. Geothermal Greenhouse Development Update

    Energy Technology Data Exchange (ETDEWEB)

    Lienau, Paul J.

    1997-01-01

    Greenhouse heating is one of the popular applications of low-to moderated-temperature geothermal resources. Using geothermal energy is both an economical and efficient way to heat greenhouses. Greenhouse heating systems can be designed to utilize low-temperature (>50oC or 122oF) resources, which makes the greenhouse an attractive application. These resources are widespread throughout the western states providing a significant potential for expansion of the geothermal greenhouse industry. This article summarizes the development of geothermal heated greenhouses, which mainly began about the mid-1970's. Based on a survey (Lienau, 1988) conducted in 1988 and updated in 1997, there are 37 operators of commercial greenhouses. Table 1 is a listing of known commercial geothermal greenhouses, we estimate that there may be an additional 25% on which data is not available.

  20. [Update Chagas disease].

    Science.gov (United States)

    Molina, Israel; Salvador, Fernando; Sánchez-Montalvá, Adrián

    2016-02-01

    The constant migration flows have favored the presence of people with Chagas disease in regions traditionally regarded as non-endemic, such as North America, Europe, Asia and Oceania. This has forced both health authorities and professionals to be updated in order to respond to such a demand for assistance. Recent years have led to significant progress in the field of diagnosis and treatment of Chagas disease, one of the most neglected tropical diseases. Recent clinical trials are providing new evidence that makes the management of these patients, a constant challenge for the professionals involved. Innovative diagnostic tools and therapeutic regimens, allow us to face the future of Chagas disease with optimism. Copyright © 2016 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  1. Y2K UPDATE

    CERN Multimedia

    Sverre JARP

    1999-01-01

    Concerning Y2K preparation, please note the following:Everybody, who has a NICE installation on his/her PC, needs to log in to NICE at least once before Xmas to get the Y2K update installed. This applies especially to dual boot systems.The test schedule on Y2Kplus.cern.ch will be prolonged. The last restart took place on 10 November and two more will take place on 24 November and 8 December, respectively. The Oracle users responsible for the maintenance of Oracle Forms applications which include PL/SQL blocks where date fields are handled with the default format are requested to contact oracle.support@cern.ch at their earliest convenience.Sverre Jarp (CERN Y2K co-ordinator, phone: 74944)

  2. Amblyopia update: new treatments.

    Science.gov (United States)

    Vagge, Aldo; Nelson, Leonard B

    2016-09-01

    This review article is an update on the current treatments for amblyopia. In particular, the authors focus on the concepts of brain plasticity and their implications for novel treatment strategies for both children and adults affected by amblyopia. A variety of strategies has been developed to treat amblyopia in children and adults. New evidence on the pathogenesis of amblyopia has been obtained both in animal models and in clinical trials. Mainly, these studies have challenged the classical concept that amblyopia becomes untreatable after the 'end' of the sensitive or critical period of visual development, because of a lack of sufficient plasticity in the adult brain. New treatments for amblyopia in children and adults are desirable and should be encouraged. However, further studies should be completed before such therapies are widely accepted into clinical practice.

  3. Update in urethral stents.

    Science.gov (United States)

    Bahouth, Z; Meyer, G; Yildiz, G; Nativ, O; Moskovitz, B

    2016-10-01

    Urethral stents were first introduced in 1988, and since then, they have undergone significant improvements. However, they did not gain a wide popularity and their use is limited to a small number of centers around the world. Urethral stents can be used in the entire urethra and for various and diverse indications. In the anterior urethra, it can be used to treat urethral strictures. In the prostatic urethra, they can be used for the treatment of prostatic obstruction, including benign, malignant and iatrogenic prostatic obstruction. Moreover, although not widely used, it can be also applied for the treatment of posterior urethral stricture and bladder neck contracture, usually resulting in urinary incontinence and the need for subsequent procedures. Our main experience are with Allium urethral stents, and as such, we provide the latest updates in urethral stents with special emphasis on the various types of Allium urethral stents: bulbar, prostatic and bladder neck stents.

  4. Update on equine allergies.

    Science.gov (United States)

    Fadok, Valerie A

    2013-12-01

    Horses develop many skin and respiratory disorders that have been attributed to allergy. These disorders include pruritic skin diseases, recurrent urticaria, allergic rhinoconjunctivitis, and reactive airway disease. Allergen-specific IgE has been detected in these horses, and allergen-specific immunotherapy is used to ameliorate clinical signs. The best understood atopic disease in horses is insect hypersensitivity, but the goal of effective treatment with allergen-specific immunotherapy remains elusive. In this review, updates in pathogenesis of allergic states and a brief mention of the new data on what is known in humans and dogs and how that relates to equine allergic disorders are discussed. Copyright © 2013 Elsevier Inc. All rights reserved.

  5. AOS clearwater project update

    Energy Technology Data Exchange (ETDEWEB)

    Palmgren, Claes [Alberta Oilsands Inc (Canada)

    2011-07-01

    The Athabasca oil sands, located in northeastern Alberta, are one of the largest deposits of bitumen in the world. In this presentation Alberta Oilsands Inc. provides an update of their two phase Clearwater project which aims at using an SLP-SAGD system to recover Athabasca bitumen. The Clearwater project site is located nearby the Fort McMurray regional airport. The idea behind the project is to utilize a low pressure SAGD system in combination with a co-injected solvent in order to extract the bitumen. The injected solvent mixes with the bitumen, decreasing its viscosity and improving its ability to flow. This type of system requires only 1000 kPa of operating pressure which leads to a lower steam to oil ratio. By the end of phase one, the Clearwater project aims at bringing in 4,500 barrels of oil per day (BOPD) and 15,000 to 25,000 BOPD by the end of phase two.

  6. Update in clinical allergy and immunology.

    Science.gov (United States)

    von Gunten, S; Marsland, B J; von Garnier, C; Simon, D

    2012-12-01

    In the recent years, a tremendous body of studies has addressed a broad variety of distinct topics in clinical allergy and immunology. In this update, we discuss selected recent data that provide clinically and pathogenetically relevant insights or identify potential novel targets and strategies for therapy. The role of the microbiome in shaping allergic immune responses and molecular, as well as cellular mechanisms of disease, is discussed separately and in the context of atopic dermatitis, as an allergic model disease. Besides summarizing novel evidence, this update highlights current areas of uncertainties and debates that, as we hope, shall stimulate scientific discussions and research activities in the field. © 2012 John Wiley & Sons A/S.

  7. Update of CERN exchange network

    CERN Multimedia

    2003-01-01

    An update of the CERN exchange network will be done next April. Disturbances or even interruptions of telephony services may occur from 4th to 24th April during evenings from 18:30 to 00:00 but will not exceed more than 4 consecutive hours (see tentative planning below). CERN divisions are invited to avoid any change requests (set-ups, move or removals) of telephones and fax machines from 4th to 25th April. Everything will be done to minimize potential inconveniences which may occur during this update. There will be no loss of telephone functionalities. CERN GSM portable phones won't be affected by this change. Should you need more details, please send us your questions by email to Standard.Telephone@cern.ch. DateChange typeAffected areas April 11 Update of switch in LHC 4 LHC 4 Point April 14 Update of switch in LHC 5 LHC 5 Point April 15 Update of switches in LHC 3 and LHC 2 Points LHC 3 and LHC 2 April 22 Update of switch N4 Meyrin Ouest April 23 Update of switch  N6 Prévessin Site Ap...

  8. Research

    African Journals Online (AJOL)

    abp

    2015-01-19

    Jan 19, 2015 ... in Cameroon. This study aimed at examining the sexual risk behaviours of high school female learners in Mbonge subdivision of rural Cameroon. ... Despite a wealth of research on youth, little research has been done on the sexual ..... Behavior, and Mental Health: a study of University Students in. Uganda.

  9. researchers

    African Journals Online (AJOL)

    African Sociological Review, 7, (2), 2003, pp.149-161. RESEARCH REPORTS. Revisiting “insiders' and 'outsiders' as social researchers. Marlize Rabe .... use of knowledgeable fieldworkers is then examined by focussing on the work ... A study by Russell (1995:p.95–97) on the long-term effects of incestuous abuse.

  10. Research

    African Journals Online (AJOL)

    2014-05-06

    May 6, 2014 ... facilitate and support articulation between the ECT mid-level worker qualification and the professional B EMC degree. Methods. The researchers used an exploratory, sequential mixed-method design, which is characterised by a qualitative phase of research followed by a quantitative phase. This design is ...

  11. Research

    African Journals Online (AJOL)

    In-depth telephonic interviews were voice recorded and transcribed. Through an inductive ... Two research assistants conducted the research to ..... Assistant Nutritionist. 1.25. M. 30.5. Single. BSc Food Science and Technology. Dietitian. 6. M. 25.6. Single. BSc Human Nutrition and Dietetics. Dietitian. 1. M. 29.6. Single.

  12. About the necessity to update the Radiological safety and protection regulations of the National Institute of Nuclear Research (ININ); Sobre la necesidad de actualizar el reglamento de proteccion y seguridad radiologica del ININ

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, J.T. [Instituto Nacional de Investigaciones Nucleares, Salazar (Mexico). Dept. de Metrologia

    1997-07-01

    It is argued the necessity to update the Radiological safety and Protection regulations (Review 3) of ININ, with the purpose that it implements the ICRU operative magnitudes system. Such a system used with radiological protection purposes. The objective of this system is to do an estimation of the effective equivalent dose H{sub E} and/or the Effective dose E, proposed in the ICRP 26 and ICRU 60 dose limits systems respectively. (Author)

  13. Updating the Psoriatic Arthritis (PsA) Core Domain Set

    DEFF Research Database (Denmark)

    Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip J

    2017-01-01

    OBJECTIVE: To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). METHODS: At OMERACT 2016, research...... conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants. RESULTS: We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted...... and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA Core Domain Set endorsed with 90% agreement by OMERACT 2016 participants included musculoskeletal disease activity, skin disease activity, fatigue, pain, patient's global assessment, physical function, health...

  14. Multiplicative updates for the LASSO

    DEFF Research Database (Denmark)

    Mørup, Morten; Clemmensen, Line Katrine Harder

    2007-01-01

    .e. least squares minimization with $L_1$-norm regularization, since the multiplicative updates (MU) can efficiently exploit the structure of the problem traditionally solved using quadratic programming (QP). We derive an algorithm based on MU for the LASSO and compare the performance to Matlabs standard QP......Multiplicative updates have proven useful for non-negativity constrained optimization. Presently, we demonstrate how multiplicative updates also can be used for unconstrained optimization. This is for instance useful when estimating the least absolute shrinkage and selection operator (LASSO), i...

  15. Updating optical pseudoinverse associative memories.

    Science.gov (United States)

    Telfer, B; Casasent, D

    1989-07-01

    Selected algorithms for adding to and deleting from optical pseudoinverse associative memories are presented and compared. New realizations of pseudoinverse updating methods using vector inner product matrix bordering and reduced-dimensionality Karhunen-Loeve approximations (which have been used for updating optical filters) are described in the context of associative memories. Greville's theorem is reviewed and compared with the Widrow-Hoff algorithm. Kohonen's gradient projection method is expressed in a different form suitable for optical implementation. The data matrix memory is also discussed for comparison purposes. Memory size, speed and ease of updating, and key vector requirements are the comparison criteria used.

  16. ADVISORY ON UPDATED METHODOLOGY FOR ...

    Science.gov (United States)

    The National Academy of Sciences (NAS) published the Biological Effects of Ionizing Radiation (BEIR) committee's report (BEIR VII) on risks from ionizing radiation exposures in 2006. The Committee analyzed the most recent epidemiology from the important exposed cohorts and factored in changes resulting from the updated analysis of dosimetry for the Japanese atomic bomb survivors. To the extent practical, the Committee also considered relevant radiobiological data, including that from the Department of Energy's low dose effects research program. Based on the review of this information, the Committee proposed a set of models for estimating risks from low-dose ionizing radiation. ORIA then prepared a white paper revising the Agency's methodology for estimating cancer risks from exposure to ionizing radiation in light of this report and other relevant information. This is the first product to be developed as a result of the BEIR VII report. We requested that the SAB conduct an advisory during the development of this methodology. The second product to be prepared will be a revised version of the document,

  17. Tetraplegia Management Update.

    Science.gov (United States)

    Fridén, Jan; Gohritz, Andreas

    2015-12-01

    Tetraplegia is a profound impairment of mobility manifesting as a paralysis of all 4 extremities owing to cervical spinal cord injury. The purpose of this article is to provide an update and analyze current management, treatment options, and outcomes of surgical reconstruction of arm and hand function. Surgical restoration of elbow and wrist extension or handgrip has tremendous potential to improve autonomy, mobility, and critical abilities, for example, eating, personal care, and self-catheterization and productive work in at least 70% of tetraplegic patients. Tendon and nerve transfers, tenodeses, and joint stabilizations reliably enable improved arm and hand usability, reduce muscle imbalance and pain in spasticity, and prevent joint contractures. One-stage combined procedures have proven considerable advantages over traditional multistage approaches. Immediate activation of transferred muscles reduces the risk of adhesions, facilitates relearning, avoids adverse effects of immobilization, and enhances functional recovery. Transfer of axillary, musculocutaneous, and radial nerve fascicles from above the spinal cord injury are effective and promising options to enhance motor outcome and sensory protection, especially in groups with limited resources. Improved communication between medical disciplines, therapists, patients, and their relatives should help that more individuals can benefit from these advances and could empower many thousands tetraplegic individuals "to take life into their own hands" and live more independently. Copyright © 2015 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

  18. Scabies: A clinical update.

    Science.gov (United States)

    Hardy, Myra; Engelman, Daniel; Steer, Andrew

    2017-01-01

    Scabies is a common, yet neglected, skin disease. Scabies occurs across Australia, but most frequently in socioeconomically disadvantaged populations in tropical regions, including in remote Aboriginal and Torres Strait Islander communities. In temperate settings, the disease clusters in institutional care facilities. The objective of this article is to provide updates on the clinical diagnosis and treatment approaches for scabies in Australia. Clinical examination remains the mainstay of diagnosis, although dermatoscopy is a useful adjunct. Scabies presents with severe itch and a papular rash, with a predilection for the hands, feet and genitalia. The distribution may be more widespread in infants and older people. Secondary bacterial infection is also common in patients with scabies. Crusted scabies is a rare but highly infectious variant. Topical permethrin is highly effective for individual treatment, but less practical for treatment of asymptomatic contacts and control of outbreaks. Oral ivermectin is a safe and effective alternative, and is now listed on the Pharmaceutical Benefits Scheme as a third-line treatment.

  19. Updates on obesity pharmacotherapy.

    Science.gov (United States)

    Velazquez, Amanda; Apovian, Caroline M

    2018-01-01

    Obesity is a chronic, relapsing disease that necessitates a multidisciplinary approach to management. Behavioral changes are the foundation to management, but adjunctive therapy is often warranted, including pharmacologic therapies and/or bariatric surgery. Until recently, treatment options included only short-term therapy (≤12 weeks), and paths beyond that schedule were challenging, as knowledge of the biology of obesity was lacking. With increased recognition of obesity as a chronic, complex medical disease, newer agents have been approved as long-term therapy, and the cornerstone of treatment is chronic behavior and lifestyle change. In the last decade, the Food and Drug Administration (FDA) has approved several new weight loss medications for the chronic management of obesity. In this review paper, we provide the latest updates on obesity pharmacotherapy. The main areas we will cover include (1) pharmacological management of obesity, (2) a review of FDA-approved weight loss medications, (3) comanagement of obesity and its metabolic sequelae (type 2 diabetes mellitus, hypertension, and dyslipidemia), and (4) obesity-centric prescribing for mental illness, neurological disorders, and contraceptive planning. © 2018 New York Academy of Sciences.

  20. Peritoneal dialysis update 1994.

    Directory of Open Access Journals (Sweden)

    Nolph K

    1994-07-01

    Full Text Available Each year there are over 400 papers published in the field of peritoneal dialysis. In this review I have touched on only a few highlights of some of the more active areas of investigation and development. The advances in controlling peritonitis rates with the Y-set have been dramatic and have resulted in peritonitis rates in many centers less than one episode per 24 patient months. Technique survivals have also improved with lower peritonitis rates. The enormous literature on new approaches to treatment and new understandings of host defenses are beyond the scope of this review. There are also many advances in peritoneal access. We now have many new types of catheters under investigation such as the Swan-Neck Missouri catheter and the Moncrief-Popovich catheter, with complete burial of the catheter until eventual externalization for CAPD training. There have been major advances in understanding the normal healing of exit sites and the early diagnosis and treatment of exit-site infections. All the extensive literature on catheter development in the management of exit sites will be reviewed elsewhere. I have focused primarily on an update of worldwide demographics, some of the new findings in peritoneal transport, the use of low-calcium solutions, experiences with EPO, new thinking about adequacy and nutrition, and finally, on recent comparisons of CAPD and hemodialysis.

  1. Research

    African Journals Online (AJOL)

    abp

    Research Team in Maternal and Child Health and Nutrition, Mohammed V. University, Rabat, Morocco. Key words: Breast cancer, risk factor, case-control study. Received: 04/01/2016 - Accepted: 17/03/2016 - Published: 06/05/2016. Abstract.

  2. Research

    Science.gov (United States)

    Mathematics Teaching, 1973

    1973-01-01

    Implications for teachers from Piagetian-oriented piagetian-oriented research on problem solving reported in an article by Eleanor Duckworth are presented. Edward de Bono's Children Solve Problems,'' a collection of examples, is also discussed. (MS)

  3. Research

    African Journals Online (AJOL)

    their academic performance, capabilities and functionings. At a tertiary educational level ... Research indicates that academic stressors, living circumstances, working conditions and where students undertake leisure activities affect academic performance .... Insufficient sleep, mild exhaustion, poor eating habits and little ...

  4. Research

    International Nuclear Information System (INIS)

    1999-01-01

    Subjects covered in this section are: (1) PCAST panel promotes energy research cooperation; (2) Letter issued by ANS urges funding balance in FFTF restart consideration and (3) FESAC panel releases report on priorities and balance

  5. Coxarthrosis - an update; Koxarthrose - ein Update

    Energy Technology Data Exchange (ETDEWEB)

    Imhof, H.; Noebauer-Huhmann, I.; Trattnig, S. [Medizinische Universitaet Wien, Klinik fuer Radiodiagnostik, Wien (Austria)

    2009-05-15

    Degenerative osteoarthritis of the hip joint (coxarthrosis) is the most common disease of the hip joint in adults. The diagnosis is based on a combination of radiographic findings and characteristic clinical symptoms. The lack of a radiographic consensus definition has seemingly resulted in a variation of the published incidences and prevalence of degenerative osteoarthritis of the hip joint. The chronological sequence of degeneration includes the following basic symptoms on conventional radiographs and CT: joint space narrowing, development of osteophytes, subchondral demineralisation/sclerosis and cyst formation, as well as loose bodies, joint malalignment and deformity. MR imaging allows additional visualization of early symptoms and/or activity signs such as cartilage edema, cartilage tears and defects, subchondral bone marrow edema, synovial edema and thickening, joint effusion and muscle atrophy. The scientific dispute concerns the significance of (minimal) joint malalignment (e.g. impingement, dysplasia etc.) and forms of malpositioning which as possible prearthrosis have a high probability of leading to degenerative osteoarthritis. Moreover, without any question, the preservation of joint containment and gender differences are important additional basic diagnostic principles, which have gained great interest in recent years. In research different MR procedures such as Na and H spectroscopy, T2*-mapping etc. with ultrahigh field MR allow cartilage metabolism and its changes in early degenerative osteoarthritis (''biochemical imaging'') to be studied. There is no doubt that even in a few years new profound knowledge is to be expected in this field. (orig.) [German] Die Hueftgelenkarthrose ist im Erwachsenenalter die haeufigste Erkrankung des Hueftgelenks. Die fehlende Konsensusdefinition dieser Erkrankung fuehrt zu einer scheinbar breiten Varianz bzgl. Inzidenz und Praevalenz. Die Diagnose wird aufgrund des radiologischen Befundes und der

  6. A research update for the Stuttgart National Aquaculture Research Center

    Science.gov (United States)

    Aquaculture (fish farming) has played an ever-increasing role in providing people with fish, shrimp, and shellfish. Aquaculture is currently the fastest growing sector of global food production and in 2016 totaled 90 million tons valued at $180 billion. The production of food-fish from aquaculture...

  7. Genomics and Health Impact Update

    Science.gov (United States)

    ... Alzheimer’s Disease Autism Breast Cancer Cardiomyopathy Colorectal Cancer Diabetes Familial Hypercholesterolemia Heart Disease Hepatitis HIV/AIDS Influenza Listeriosis Lynch Syndrome Malaria Osteoporosis Sudden Death Tuberculosis Zika Virus Updates on Specific Topics Big Data ...

  8. Argonne Wakefield Accelerator Update '92

    International Nuclear Information System (INIS)

    Rosing, M.; Balka, L.; Chojnacki, E.; Gai, W.; Ho, C.; Konecny, R.; Power, J.; Schoessow, P.; Simpson, J.

    1992-01-01

    The Argonne Wakefield Accelerator (AWA) is an experiment designed to test various ideas related to wakefield technology. Construction is now underway for a 100 nC electron beam in December of 1992. This report updates this progress

  9. A pessimistic view of optimistic belief updating.

    Science.gov (United States)

    Shah, Punit; Harris, Adam J L; Bird, Geoffrey; Catmur, Caroline; Hahn, Ulrike

    2016-11-01

    Received academic wisdom holds that human judgment is characterized by unrealistic optimism, the tendency to underestimate the likelihood of negative events and overestimate the likelihood of positive events. With recent questions being raised over the degree to which the majority of this research genuinely demonstrates optimism, attention to possible mechanisms generating such a bias becomes ever more important. New studies have now claimed that unrealistic optimism emerges as a result of biased belief updating with distinctive neural correlates in the brain. On a behavioral level, these studies suggest that, for negative events, desirable information is incorporated into personal risk estimates to a greater degree than undesirable information (resulting in a more optimistic outlook). However, using task analyses, simulations, and experiments we demonstrate that this pattern of results is a statistical artifact. In contrast with previous work, we examined participants' use of new information with reference to the normative, Bayesian standard. Simulations reveal the fundamental difficulties that would need to be overcome by any robust test of optimistic updating. No such test presently exists, so that the best one can presently do is perform analyses with a number of techniques, all of which have important weaknesses. Applying these analyses to five experiments shows no evidence of optimistic updating. These results clarify the difficulties involved in studying human 'bias' and cast additional doubt over the status of optimism as a fundamental characteristic of healthy cognition. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

  10. Efficient Synthesis of Network Updates

    Science.gov (United States)

    2015-06-17

    Pavol Černý CU Boulder pavol.cerny@colorado.edu Nate Foster Cornell University jnfoster@cs.cornell.edu Abstract Software-defined networking ( SDN ...is revolutionizing the net- working industry, but current SDN programming platforms do not provide automated mechanisms for updating global...configurations on the fly. Implementing updates by hand is challenging for SDN programmers because networks are distributed systems with hun- dreds or thousands

  11. Communication technology update and fundamentals

    CERN Document Server

    Grant, August E

    2010-01-01

    New communication technologies are being introduced at an astonishing rate. Making sense of these technologies is increasingly difficult. Communication Technology Update and Fundamentals is the single best source for the latest developments, trends, and issues in communication technology. Featuring the fundamental framework along with the history and background of communication technologies, Communication Technology Update and Fundamentals, 12th edition helps you stay ahead of these ever-changing and emerging technologies.As always, every chapter ha

  12. Communication technology update and fundamentals

    CERN Document Server

    Grant, August E

    2008-01-01

    New communication technologies are being introduced at an astonishing rate. Making sense of these technologies is increasingly difficult. Communication Technology Update is the single best source for the latest developments, trends, and issues in communication technology. Now in its 11th edition, Communication Technology Update has become an indispensable information resource for business, government, and academia. As always, every chapter has been completely rewritten to reflect the latest developments and market statistics, and now covers mobile computing, dig

  13. Decentralized Consistent Updates in SDN

    KAUST Repository

    Nguyen, Thanh Dang

    2017-04-10

    We present ez-Segway, a decentralized mechanism to consistently and quickly update the network state while preventing forwarding anomalies (loops and blackholes) and avoiding link congestion. In our design, the centralized SDN controller only pre-computes information needed by the switches during the update execution. This information is distributed to the switches, which use partial knowledge and direct message passing to efficiently realize the update. This separation of concerns has the key benefit of improving update performance as the communication and computation bottlenecks at the controller are removed. Our evaluations via network emulations and large-scale simulations demonstrate the efficiency of ez-Segway, which compared to a centralized approach, improves network update times by up to 45% and 57% at the median and the 99th percentile, respectively. A deployment of a system prototype in a real OpenFlow switch and an implementation in P4 demonstrate the feasibility and low overhead of implementing simple network update functionality within switches.

  14. Updated science systems on USCGC Healy

    Science.gov (United States)

    Chayes, D. N.; Roberts, S. D.; Arko, R. A.; Hiller, S. M.

    2008-12-01

    The USCG cutter Healy is the U.S. Arctic research icebreaker. Prior to the 2008 season, a number of upgrades and improvements were made to the science systems. These included the addition of two Bell BGM-3 marine gravity meters. The vessel's existing meterological sensors were enhanced with two RM Young model 85004 heated ultrasonic anemometers; a Paroscientific, Inc. model "MET-3A" air temperature, humidity and barometric pressure subsystem; and an RM Young model 50202 heated rain gauge. The flow through sea water system was updated with new flow meters, a SeaBird SBE45 thermosalinograph, long and a short wave radiation sensors, a Seapoint fluorometer. A Milltech Marine Smart Radio model SR161 Automatic Identification System (AIS) receiver and an updated interface to real-time winch and wire performance have been added. Our onboard real-time GIS has been updated to include real-time plotting of other ship tracks from our AIS receiver and the ability for users to save and share planned tracks. For the HLY0806 leg, we implemented a SWAP ship-to ship wireless connection for our two-ship operations with the Canadian icebreaker Louis S. St. Laurent similar to the one we implemented for our two-ship program with the Swedish icebreaker Oden in 2005. We updated our routine delivery of underway data to investigators, as well as a copy for archiving to the NSF-supported Marine Geoscience Data System (MGDS), using portable "boomerang" drives. An end-user workstation was added to accommodate increasing demand for onboard processing. Technical support for science on the Healy is supported by the U.S. National Science Foundation.

  15. Nova Scotia electricity update

    International Nuclear Information System (INIS)

    Crandlemire, A.L.

    2004-01-01

    This paper provides an update of electricity issues concerning Nova Scotia such as supply, capacity, emission commitments, as well as co-generation and the Electricity Marketplace Governance Committee (EMGC). The goals of the strategy were reliability combined with competitive prices and greater environmental responsibility. The scope of these objectives included new capacity, transmission, renewables and co-generation. Other objectives included encouraging wholesale market competition; meeting reciprocity requirements; and a 50 MW renewable energy target. Recommendations of the EMGC included wholesale market competition; a broader market scope with a cost benefit analysis; Open Access Transmission Tariff (OATT); a scheduling and information system; network integration and a point to point service; and a separation of transmission and generation business units. Other recommendations included an open competitive process for new generation; a consideration of emissions and overall efficiency; a Renewable Energy Portfolio Standard (RPS) to start in 2006; the separation of RPS tags from electricity; and net metering of renewables. These recommendations were accepted in 2003, followed by the new Electricity Act in 2004, which made OATT mandatory, established RPS and opened to the wholesale market. Capacity at present was considered to be tight, with preparations for the new regulations under way. Reductions in air pollution were reported at 25 per cent, with renewable energy projects such as 2 windmills currently under way, as well as various other projects. Opportunities for provincial Atlantic cooperation were identified as being management of reserve requirements; trading of lowest cost electricity; new generation on a regional scale; stronger transmission ties; a system operator; a regional approach to RPS; regional management of air emissions; and regional opportunities for Carbon dioxide reductions. tabs., figs

  16. NB market update

    International Nuclear Information System (INIS)

    Marshall, W. K.

    2004-01-01

    The 2004 New Brunswick proclamation introduced several changes to the industry. This paper presents an update of the current New Brunswick electricity market from the perspective of the recently created New Brunswick System Operator (NBSO). A comparison was made between the modified industry and the previous industry structure. Significant changes included: corporate restructuring and market implementation; the formation of the independent system operator; and an increase in Public Utilities Board regulatory authority. The main objectives of the NBSO were reviewed, including its intention to reliably plan and operate the integrated power system as well as facilitating and operating the electricity market. Details of directors and officers were provided along with a list of legislated functions which included entering agreements with transmitters; provision and procurement of ancillary services; maintenance of integrated system; coordination of external activities; participation with standards authorities; planning and development of transmission; and the facilitation of a competitive market. An outline of the NBSO, Transco and Public Utilities Board relationships were presented. Details of the market advisory committee were outlined, with information concerning contracts, operations and services agreements. Transmission and ancillary services were also discussed, as well as issues concerning interruptible load agreements. A chart of the New Brunswick electricity market structure was presented, along with a market overview including details of capacity, ancillary services and suppliers. Market rules and amendments were presented, as well as market participation guides. Details of generation resource adequacy requirements and the imposition of penalties were outlined. Scheduling and dispatch issues were overviewed, as well as settlement processes, inputs and their sources, including settlements for variances. Future development possibilities included an expansion of

  17. Herpes Labialis: An Update.

    Science.gov (United States)

    Leung, Alexander K C; Barankin, Benjamin

    2017-01-01

    Herpes labialis is characterized by recurrent vesicular eruptions primarily on the lips and perioral skin. The condition is contagious, can cause significant discomfort/pain, and can have an adverse effect on the quality of life. To update the evaluation and treatment of herpes labialis. A PubMed search was completed in Clinical Queries using the key term "herpes labialis". Patents were searched using the key term "herpes labialis" from www.freepatentsonline.com. The diagnosis of herpes labialis is mainly clinical based on classic grouped lesions (papules, vesicles, ulcers) on the lip. Antiviral therapy shortens the duration of pain and discomfort, hastens healing, and reduces viral shedding. Thus, episodic treatment is warranted, especially if the patient desires treatment for cosmetic purposes or for relief of pain. Such treatment needs to be initiated promptly, ideally in the prodromal stage and no later than 48 hours from the onset of lesions to achieve optimal results. Chronic suppressive therapy with oral antiviral agents should be considered for patients with severe or frequent (six or more episodes per year) recurrences. Recent patents related to the management of herpes labialis are also discussed. For episodic treatment, oral antiviral agents, such as acyclovir (Zovirax), valacyclovir (Valtrex) and famciclovir (Famvir), are superior to topical antiviral therapy. Valacyclovir and famciclovir have greater oral bioavailability and are better absorbed than acyclovir, require less frequent dosing, but are more expensive and are not approved for children. Topical antiviral agents such as 5% acyclovir cream/ointment (Zovirax) ± hydrocortisone (Xerese), 1% penciclovir (Denavir) cream, and 50 mg Buccal Adhesive Tablet (ABT-50 mg) can also be used for episodic treatment of herpes labialis. These topical agents are not effective in the prevention of recurrent herpes labialis. For chronic daily suppressive therapy, oral antivirals are the treatment of choice

  18. Research

    African Journals Online (AJOL)

    ebutamanya

    2016-03-24

    Mar 24, 2016 ... national non-governmental organization (NGO) ”Arc en Ciel„. This. NGO, which is familiar with research activities, identified the MSM community leaders in the .... whom there is an emotional attachment) in both homosexual and heterosexual populations [14, 19]. Like other reports from. Cameroon [19] and ...

  19. Research

    African Journals Online (AJOL)

    raoul

    2012-01-11

    Jan 11, 2012 ... 1MPH Programme, Department of Community Medicine, University of Zimbabwe, Zimbabwe, 2Department of Epidemiology and Disease Control,. Ministry ... Pan African Medical Journal. 2012; 11: ..... Mufuta Tshimanga: Had oversight of all the stages of the research and critically reviewed the final draft for.

  20. Research

    African Journals Online (AJOL)

    raoul

    2011-08-25

    Aug 25, 2011 ... euthanasia were also queried. Data was analyzed using Epidata, SPSS 16.0 and Microsoft Excel. Results: Thirty-eight (97.4%) of thirty-nine institutions reported using animals for education and/or research. Thirty (76.9%) institutions reported using analgesics or anesthetics on a regular basis. Thirteen ...

  1. Research

    African Journals Online (AJOL)

    abp

    2016-02-01

    Feb 1, 2016 ... University Hospital, DK-5000 Odense, Denmark, 3Center for Global Health, Institute of Clinical Research, University of Southern Denmark, DK-5000. Odense .... BHP is a Danish-Guinean Demographic Surveillance Site with a study-area .... variables such as age groups, previous military duty, history of.

  2. Research

    African Journals Online (AJOL)

    Research. May 2016, Vol. 8, No. 1 AJHPE 37. Students who enrol in occupational therapy (OT) at the. University of Kwa Zulu-Natal (UKZN), Durban, South Africa ... The latter may include becoming familiar with the disintegrating social systems in primary .... They also lacked the skills needed to adapt sessions and failed to ...

  3. Research

    African Journals Online (AJOL)

    raoul

    2011-12-14

    Dec 14, 2011 ... skills through hands-on application of epidemiology to real public health issues. For the most part, residents carry out research projects in priority areas of the districts they are attached, often under direct supervision of the local or provincial health leaders [2]. In Africa, these programs formed a networking ...

  4. Research

    African Journals Online (AJOL)

    abp

    2014-03-21

    Mar 21, 2014 ... Published in partnership with the African Field Epidemiology Network (AFENET). (www.afenet.net). Research ... were intervention strategies for primary health care delivery at the district and community levels ..... to be a gap between policy formation and implementation as only immunization services are.

  5. Research

    African Journals Online (AJOL)

    abp

    2013-03-05

    Mar 5, 2013 ... food market) [10]. There are few studies that provide data on NCDs from Africa and these are mainly from South Africa [11]. In the same vein, research efforts in The .... males, in view of the relationships between obesity, physical inactivity and .... pronged intervention strategies-epidemiological surveillance,.

  6. Research

    African Journals Online (AJOL)

    ebutamanya

    2015-11-23

    Nov 23, 2015 ... 1Amref Health Africa, P.O Box 2773 Dar es Salaam, Tanzania, 2Kilimanjaro Reproductive Health Program, Moshi, Tanzania, 3Population Services. International, Nairobi .... testing, HIV testing history and HIV test results. ..... due to differences in the research designs, nature of population and sample size ...

  7. Research

    African Journals Online (AJOL)

    ebutamanya

    2015-06-22

    Jun 22, 2015 ... collaboration with Makerere University, School of Public Health. We acknowledge The Family Health Research and Development Centre. (FHRDC) Uganda. Supported by Bill & Melinda Gates Institute for. Population & Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, ...

  8. Research

    African Journals Online (AJOL)

    abp

    2016-04-14

    Apr 14, 2016 ... Methods. Study design: A mixed method cross-sectional design using both quantitative and qualitative research methods as described by. Hanson et al [33] was employed. Settings: The study was based on data from the midterm evaluation that was conducted between August-December 2012 involving ...

  9. Research

    African Journals Online (AJOL)

    The study followed a qualitative research design using semi-structured interviews with full-time SA- or foreign-qualified specialists at. Kimberley Hospital ... average number of weekly hours spent on undergraduate student training ... The best place to learn is at the bedside; a student should see the patient, read up and ...

  10. Research

    African Journals Online (AJOL)

    the importance of the learning setting (curriculum context), a capability approach to learning (the process), and the production of expert generalists. (the outcome) .... including communication, learning transfer, teamwork, self-confidence, and reciprocal and effective practice.[6-8] Research also shows that PAL provides a.

  11. Research

    African Journals Online (AJOL)

    raoul

    2011-11-14

    Nov 14, 2011 ... Data were collected between February and March 2010 using a questionnaire, designed by the researcher. It comprised two sections; the ..... Bazant ES, Koenig MA, Fotso J-C, Mills S. Women's Use of Private and Government Health Facilities for Childbirth in Nairobi's Informal. Settlements. Stud Fam Plann ...

  12. Research

    African Journals Online (AJOL)

    Research. This article provides a detailed description of the development of an evaluation matrix that represents the organising structure for evaluating the impact of the interdisciplinary health-promotion course on multiple stakeholders. The evaluation was designed to answer the questions relating to the perceptions and ...

  13. Research

    African Journals Online (AJOL)

    2017-03-18

    Mar 18, 2017 ... promote CPD by working in partnership with employers, academic institutions ... SORK, employers and institutions of higher education all have a responsibility towards the culture of lifelong learning. As the ... further approved by the Higher Degrees and Research Ethics Committees of the University of ...

  14. Research

    African Journals Online (AJOL)

    abp

    2014-08-29

    Aug 29, 2014 ... Page number not for citation purposes ... Pan African Medical Journal – ISSN: 1937- 8688 (www.panafrican-med-journal.com). Published in partnership with the African Field Epidemiology Network (AFENET). (www.afenet.net). Research .... and education, hence a higher risk of morbidity and mortality and a.

  15. Research

    African Journals Online (AJOL)

    tions as their reality.[14]. Research context. At Stellenbosch University (SU), Cape Town,. SA, final-year physiotherapy students each spend. 6 weeks at a community site learning to integrate and apply the principles of PHC and community- based rehabilitation. Approximately 5 - 10 clients are seen in their homes per week.

  16. Research

    African Journals Online (AJOL)

    the classroom.[9] Cognitive learning is achieved when students can make connections among and interpret different aspects of a subject to apply what they have learned in other fields of ... the effect of the field trips on the students' perceptions. ... researcher in higher education teaching and learning facilitated the data-.

  17. Research

    African Journals Online (AJOL)

    ebutamanya

    2015-12-02

    Dec 2, 2015 ... It is an important aspect of quality of life which is often neglected by people in this age group, attending physicians and the society as a whole. The study was aimed at determining ... or a trained research assistant for those who could neither read nor write. Consenting individuals above this age who have ...

  18. Research

    African Journals Online (AJOL)

    abp

    2014-01-31

    Jan 31, 2014 ... by Hazarika in a population-based study in India. The researcher noted that patients' preference to the private health facilities was due mainly to their dissatisfaction with the services in the public health facilities [11]. Furthermore, the quality of the services in the private health facilities could also be a major ...

  19. Research

    African Journals Online (AJOL)

    abp

    2017-11-30

    Nov 30, 2017 ... Authors' contributions. All the authors have read and agreed to the final manuscript. Acknowledgments. The author was supported by a postdoctoral fellowship awarded by the South African National Research Foundation (NRF). The content of this manuscript does not necessarily represent the official views.

  20. Research

    African Journals Online (AJOL)

    abp

    2017-12-05

    Dec 5, 2017 ... work is properly cited. Pan African Medical Journal – ISSN: 1937- 8688 ... an unfinished business as dozens of studies reveal millions of children worldwide have not yet benefited from the .... regions included in the research site [24]. Results. In the final analysis, three working themes were generated.

  1. Research

    African Journals Online (AJOL)

    Workshop on {topic}; research project; clinical practical experience. Outputs. Tangible products/by-products of activities (but not whether students learned anything). Certificates of completion; records of actions by participants (i.e. log books); number of students at clinical site. Intermediate outcomes Learning connected to ...

  2. Research

    African Journals Online (AJOL)

    abp

    2017-05-18

    May 18, 2017 ... available to populations of developing countries [2-5]. In 2013, in. Western and Central Europe and ..... initiation among the infected persons in the community. Addressing stigma and educating ... Lifespan/Tufts/Brown Center for AIDS Research (P30AI042853). Tables. Table 1: Baseline characteristics of ...

  3. Research

    African Journals Online (AJOL)

    2014-05-18

    May 18, 2014 ... Research. Practice within the clinical arena is recognised as the best means of socialising students into the physiotherapy profession[1-5] and is known to ..... A ect. Intervention. Overall preparedness. Fig. 1. Means and 95% CIs of the mean scores of each component (n=58; 9 missing). There is a significant ...

  4. Research

    African Journals Online (AJOL)

    YouTube, TED and other podcast websites. Other researchers have also documented their procedures. Corl et al.[5] describe the basic process of producing a podcast, and Jham et al.[6] list a number of universities actively doing podcasts. Besides the lecture podcasts, we have also captured numerous clinical.

  5. Literature searches on Ayurveda: An update.

    Science.gov (United States)

    Aggithaya, Madhur G; Narahari, Saravu R

    2015-01-01

    The journals that publish on Ayurveda are increasingly indexed by popular medical databases in recent years. However, many Eastern journals are not indexed biomedical journal databases such as PubMed. Literature searches for Ayurveda continue to be challenging due to the nonavailability of active, unbiased dedicated databases for Ayurvedic literature. In 2010, authors identified 46 databases that can be used for systematic search of Ayurvedic papers and theses. This update reviewed our previous recommendation and identified current and relevant databases. To update on Ayurveda literature search and strategy to retrieve maximum publications. Author used psoriasis as an example to search previously listed databases and identify new. The population, intervention, control, and outcome table included keywords related to psoriasis and Ayurvedic terminologies for skin diseases. Current citation update status, search results, and search options of previous databases were assessed. Eight search strategies were developed. Hundred and five journals, both biomedical and Ayurveda, which publish on Ayurveda, were identified. Variability in databases was explored to identify bias in journal citation. Five among 46 databases are now relevant - AYUSH research portal, Annotated Bibliography of Indian Medicine, Digital Helpline for Ayurveda Research Articles (DHARA), PubMed, and Directory of Open Access Journals. Search options in these databases are not uniform, and only PubMed allows complex search strategy. "The Researches in Ayurveda" and "Ayurvedic Research Database" (ARD) are important grey resources for hand searching. About 44/105 (41.5%) journals publishing Ayurvedic studies are not indexed in any database. Only 11/105 (10.4%) exclusive Ayurveda journals are indexed in PubMed. AYUSH research portal and DHARA are two major portals after 2010. It is mandatory to search PubMed and four other databases because all five carry citations from different groups of journals. The hand

  6. Nuclear technology review 2005 update

    International Nuclear Information System (INIS)

    2005-08-01

    The year 2004 marked the 50th anniversary of civilian nuclear power generation. While the current outlook for nuclear energy remains mixed, there is clearly a sense of rising expectations. Both the OECD International Energy Agency and the IAEA adjusted their medium-term projections for nuclear power upwards. The IAEA now projects 423 - 592 GW(e) of nuclear power installed worldwide in 2030, compared to 366 GW(e) at the end of 2004. This is driven by nuclear power's performance record, by growing energy needs around the world coupled with rising oil and natural gas prices, by new environmental constraints including entry-into-force of the Kyoto Protocol, by concerns about energy supply security in a number of countries, and by ambitious expansion plans in several key countries. National research on advanced reactor designs continues on all reactor categories - water cooled, gas cooled, liquid metal cooled, and hybrid systems. Five members of the US-initiated Generation IV International Forum (GIF) signed a framework agreement on international collaboration in research and development on Generation IV nuclear energy systems in February 2005. The IAEA's International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) grew to 23 members. It completed a series of case studies testing its assessment methodology and the final report on the updated INPRO methodology was published in December. The realization of the International Thermonuclear Experimental Reactor, ITER, came closer with the announcement on 28 June 2005 by the ITER parties. The aim of ITER is to demonstrate the scientific and technological feasibility of fusion energy by constructing a functional fusion power plant. Nuclear technology developments are rapid and cover many fields of application. Not all can be covered in this update review, but certain key areas and trends are covered where these are seen to be of significant interest to IAEA Member States, and which are of relevance to and have

  7. Who's Who? Memory updating and character reference in children's narratives.

    Science.gov (United States)

    Whitely, Cristy; Colozzo, Paola

    2013-10-01

    The capacity to update and monitor the contents of working memory is an executive function presumed to play a critical role in language processing. The current study used an individual differences approach to consider the relationship between memory updating and accurate reference to story characters in the narratives of typically developing children. English-speaking children from kindergarten to grade 2 ( N = 63; M age = 7.0 years) completed updating tasks, short-term memory tasks, and narrative productions. The authors used multiple regression to test whether updating accounted for independent variability in referential adequacy. The capacity to update working memory was related to adequate character reference beyond the effects of age and of short-term memory capacity, with the strongest relationship emerging for maintaining reference over multiple utterances. This individual differences study is the first to show a link between updating and performance in a discourse production task for young school-age children. The findings contribute to the growing body of research investigating the role of working memory in shaping language production. This study invites extension to children of different ages and language abilities as well as to other language production tasks.

  8. CCRA-9 2014 update

    OpenAIRE

    Thompson, T.L.; Thomason, W.E.

    2014-01-01

    This PowerPoint summarizes the research activities and findings of SANREM’s soil quality and soil carbon sequestration cross-cutting research activity. The presentation describes studies of soil carbon dioxide, GIS agroclimatology comparisons, and density fractionation of soil carbon. CCRA-9 (Soil Quality and Soil Carbon Sequestration)

  9. Liver Transplantation Update: 2014.

    Science.gov (United States)

    Dogan, Serkan; Gurakar, Ahmet

    2015-01-01

    of organs donated after cardiac death. Herein, we briefly summarize recent advances in knowledge related to LT. We also report common causes of death after liver transplant, including the recurrence of hepatitis C virus (HCV) and its management, and coronary artery disease (CAD), including the role of the cardiac calcium score in identifying occult CAD. Dogan S, Gurakar A. Liver Transplantation Update: 2014. Euroasian J Hepato-Gastroenterol 2015;5(2):98-106.

  10. VIIP 2017 Clinical Update

    Science.gov (United States)

    Tarver, William

    2017-01-01

    INTRODUCTION: NASA's Space Medicine community knowledge regarding the "Vision Impairment Intracranial Pressure", or VIIP.has been evolving over time.. Various measures of occupational health related to this condition had to be determined and then plans/processes put into place. The most robust of these processes were inititated in 2010. This presentation will provide a clinic update of the astronaut occupational health data related to VIIP. METHODS: NASA and its international partners require its astronauts to undergo routine health measures deemed important to monitoring VIIP. The concern is that the spaceflight environment aboard ISS could cause some astronauts to have physiologic changes detrimental to either ongoing mission operations or long-term health related to the ocular system and possibly the CNS. Specific medical tests include but are not limited to brain/orbit MRI (NASA unique protocol), OCT, fundoscopy and ocular ultrasound. Measures are taken prior to spaceflight, in-flight and post-flight. Measures to be reported include incidence of disc edema, globe flattening, choroidal folds, ONSD and change in refractive error. RESULTS: 73 ISS astronauts have been evaluated at least partially for VIIP related measures. Of these individuals, approximately 1 in 7 have experienced disc edema. The prevalence of the other findings is more complicated as the medical testing has changed over time. Overall, 26 separate individuals have experienced at least one of the findings NASA has associated with VIIP Another confounding factor is most of the astronauts have prior spaceflight experience at the time of the "pre-flight" testing. DISCUSSION: In 2010 NASA and its US operating segment (USOS) partners (CSA, ESA and JAXA) began routine occupational monitoring and data collection for most VIIP related changes. Interpretation of that data is extremely challenging for several reasons. For example, the determination of disc edema is the most complete finding as we have had

  11. 2016 Updated MASCC/ESMO Consensus Recommendations

    DEFF Research Database (Denmark)

    Olver, Ian; Ruhlmann, Christina H.; Jahn, Franziska

    2017-01-01

    Purpose: The purpose of this review is to update the MASCC (Multinational Association of Supportive Care in Cancer) guidelines for controlling nausea and vomiting with chemotherapy of low or minimal emetic potential. Methods: The antiemetic study group of MASCC met in Copenhagen in 2015 to review...... emetogenicity, no antiemetic should be routinely administered. If patients vomit, they should be treated as for chemotherapy of low emetic potential. No antiemetic should be administered for prevention of delayed nausea and vomiting induced by low or minimally emetogenic chemotherapy. Conclusions: More research...

  12. An update on inflammatory breast cancer

    Directory of Open Access Journals (Sweden)

    P. Thapaliya

    2011-12-01

    Full Text Available Inflammatory breast cancer is one of the most aggressive forms of breast cancer. Once considered to be a uniformly fatal disease, treatment of this entity has evolved significantly over the last two decades. In this article, we review the epidemiology, pathology, biologic underpinnings, radiologic advances, and treatment modalities for inflammatory breast cancer. Updates in surgical therapy, medical oncologic therapy and radiation therapy are reviewed. Emphasis is on cutting edge information regarding inflammatory breast cancer. The management of inflammatory breast cancer is best served by a multidisciplinary team. Continued research into molecular pathways and potential targets is imperative. Future clinical trials should include evaluation of conventional therapy with targeted therapies.

  13. Update on pathology of ocular parasitic disease

    Directory of Open Access Journals (Sweden)

    Dipankar Das

    2016-01-01

    Full Text Available Parasites are a group of eukaryotic organisms that may be free-living or form a symbiotic or parasitic relationship with the hosts. Consisting of over 800,000 recognized species, parasites may be unicellular (Protozoa or multicellular (helminths and arthropods. The association of parasites with human population started long before the emergence of civilization. Parasitic zoonotic diseases are prevalent worldwide including India. Appropriate epidemiological data are lacking on existing zoonotic parasitic diseases, and newer diseases are emerging in our scenario. Systemic diseases such as cysticercosis, paragonimiasis, hydatidosis, and toxoplasmosis are fairly common. Acquired Toxoplasma infections are rising in immune-deficient individuals. Amongst the ocular parasitic diseases, various protozoas such as Cystoidea, trematodes, tissue flagellates, sporozoas etc. affect humans in general and eyes in particular, in different parts of the world. These zoonoses seem to be a real health related problem globally. Recent intensification of research throughout the world has led to specialization in biological fields, creating a conducive situation for researchers interested in this subject. The basics of parasitology lie in morphology, pathology, and with recent updates in molecular parasitology, the scope has extended further. The current review is to address the recent update in ophthalmic parasites with special reference to pathology and give a glimpse of further research in this field.

  14. Updating the OMERACT filter

    DEFF Research Database (Denmark)

    Kirwan, John R; Boers, Maarten; Hewlett, Sarah

    2014-01-01

    OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Filter provides guidelines for the development and validation of outcome measures for use in clinical research. The "Truth" section of the OMERACT Filter presupposes an explicit framework for identifying the relevant core outcomes that are......OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Filter provides guidelines for the development and validation of outcome measures for use in clinical research. The "Truth" section of the OMERACT Filter presupposes an explicit framework for identifying the relevant core outcomes...

  15. Obesity management: Update on orlistat

    Directory of Open Access Journals (Sweden)

    Belinda S Drew

    2008-01-01

    Full Text Available Belinda S Drew, Andrew F Dixon, John B DixonCentre for Obesity Research and Education, Monash University, Melbourne, AustraliaAbstract: Over the past 20 years obesity has become a worldwide concern of frightening proportion. The World Health Organization estimates that there are over 400 million obese and over 1.6 billion overweight adults, a figure which is projected to almost double by 2015. This is not a disease restricted to adults – at least 20 million children under the age of 5 years were overweight in 2005 (WHO 2006. Overweight and obesity lead to serious health consequences including coronary artery disease, stroke, type-2 diabetes, heart failure, dyslipidemia, hypertension, reproductive and gastrointestinal cancers, gallstones, fatty liver disease, osteoarthritis and sleep apnea (Padwal et al 2003.Modest weight loss in the obese of between 5% and 10% of bodyweight is associated with improvements in cardiovascular risk profiles and reduced incidence of type 2 diabetes (Goldstein 1992; Avenell et al 2004; Padwal and Majumdar 2007. Orlistat, a gastric and pancreatic lipase inhibitor that reduces dietary fat absorption by approximately 30%, has been approved for use for around ten years (Zhi et al 1994; Hauptman 2000. There is now a growing body of evidence to suggest that Orlistat assists weight loss and that it may also have additional benefits. The aim of this review is to provide a brief update on the current literature studying the efficacy, safety and significance of the use of Orlistat in clinical practice.Keywords: obese, weight, diet, orlistat, hypertension, cholesterol

  16. READING STATISTICS AND RESEARCH

    OpenAIRE

    Reviewed by Yavuz Akbulut

    2008-01-01

    The book demonstrates the best and most conservative ways to decipher and critique research reports particularly for social science researchers. In addition, new editions of the book are always better organized, effectively structured and meticulously updated in line with the developments in the field of research statistics. Even the most trivial issues are revisited and updated in new editions. For instance, purchaser of the previous editions might check the interpretation of skewness and ku...

  17. Biological pathways, candidate genes, and molecular markers associated with quality-of-life domains: an update

    NARCIS (Netherlands)

    Sprangers, Mirjam A. G.; Thong, Melissa S. Y.; Bartels, Meike; Barsevick, Andrea; Ordoñana, Juan; Shi, Qiuling; Wang, Xin Shelley; Klepstad, Pål; Wierenga, Eddy A.; Singh, Jasvinder A.; Sloan, Jeff A.; Abertnethy, Amy P.; Baas, Frank; Barsevick, Andrea M.; Boomsma, Dorret I.; Bottomley, Andrew; Brundage, Michael; Cella, David; Chauhan, Cynthia; Cleeland, Charles S.; Coens, Corneel; Dueck, Amylou C.; Frost, Marlene H.; Hall, Per; Halyard, Michele Y.; van Laarhoven, Hanneke W. M.; Martin, Nicholas G.; Miaskowski, Christine; Mosing, Miriam; Movsas, Benjamin; Oliveira, Joao R.; Patrick, Donald L.; Pedersen, Nancy L.; Raat, Hein; Reeve, Bryce; Stephen, Ristvedt; Ropka, Mary E.; Schwartz, Carolyn; Shi, Quiling; Shinozaki, Gen; Swaab, Dick; Talwalkar, Jayant; Thong, Melissa; van Noorden, Cornelis J. F.; Veenhoven, Ruut; Wagner, Gert; Wierenga, Eddy; Yang, Ping; Zwinderman, Ailko H.

    2014-01-01

    There is compelling evidence of a genetic foundation of patient-reported quality of life (QOL). Given the rapid development of substantial scientific advances in this area of research, the current paper updates and extends reviews published in 2010. The objective was to provide an updated overview

  18. Nephrogenic systemic fibrosis: epidemiology update

    DEFF Research Database (Denmark)

    Marckmann, P.

    2008-01-01

    Purpose of review The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. Recent findings Epidemiological and histochemical studies demonstrated that gadoli......Purpose of review The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. Recent findings Epidemiological and histochemical studies demonstrated...

  19. Lignite coal council update

    International Nuclear Information System (INIS)

    Dwyer, J.W.

    1992-01-01

    The proceedings contain an outline only of the paper presented at the conference, but major points are distinguishable. The discussion included a summary of major programs, government action programs, public relations and the education program, research and development programs, and challenges of the future

  20. Updating design information questionnaire (DIQ) experiences

    International Nuclear Information System (INIS)

    Palafox-Garcia, P.

    2001-01-01

    , we had to update our two DIQ's and we have to go through the previous mentioned steps, that means that in order to get the updated Facility Attachment for our MBA's, we have to wait at least two years, and meanwhile the IAEA Safeguards Inspectors have to deal without the proper Facility Attachment during their inspections in the facility, but the main problem is that meanwhile we are dealing with the updated DIQ's, unexpected changes have been occurred in one of the MBA's. The situation we are facing in the MBA is, now that the Fuel Fabrication Pilot Plant (FFPP) was stopped, they want to take advantage of certain part of this area and some equipment in order of work at the facility as a research level, but meanwhile the nuclear material is still there, they have to comply with all the requirements of security, physical, radiological and safeguards, so they are planning to leave at the MBA, a small quantity of nuclear material in order that the security regulations to comply with, there were no so difficult, laborious and expensive. The most of the nuclear material is planned to pack it in 200 It. metallic drums and send it to the other MBA. 4. Conclusion - The updated DIQ we are dealing with, was sent after they stopped the FFPP and when we will get the updated Facility Attachment will send a third more updated DIQ and this it will be as soon as they could solve all the permissions and requirements needed for the maneuvers previously described and we do not know how long it will takes, but they are working on it. As a proposal, in order to avoid that length of time to get the new Facility Attachment, the IAEA has to establish to the facilities a delivering time for each review. (author)

  1. Update on Pediatric Cough.

    Science.gov (United States)

    Kantar, Ahmad

    2016-02-01

    Despite the high prevalence of cough in children, the topic has been poorly researched. Although pediatricians recognize that chronic cough in children is different from that in adults, this difference seems less recognizable to other health professionals. During childhood, the respiratory tract and nervous system undergo a series of anatomical and physiological maturation processes that influence the cough reflex. Additionally, immunological responses undergo developmental and memorial processes that make infection and congenital abnormalities the overwhelming cause of cough in children. The lack of comprehensive clinical data regarding chronic cough in children has initially required pediatricians to adopt an adult approach to the problem. In the last 10 years, however, research has led to the reconsideration of the etiology of chronic cough in children. Currently, attention has focused on protracted bacterial bronchitis as a major cause of chronic cough in preschool-aged children and as a possible precursor of bronchiectasis. New research horizons are emerging for both the treatment and prevention of particular causes of chronic cough in children.

  2. An Update on the Effects of Playing Violent Video Games

    Science.gov (United States)

    Anderson, Craig, A.

    2004-01-01

    This article presents a brief overview of existing research on the effects of exposure to violent video games. An updated meta-analysis reveals that exposure to violent video games is significantly linked to increases in aggressive behaviour, aggressive cognition, aggressive affect, and cardiovascular arousal, and to decreases in helping…

  3. Updated Meta-Analysis of Learner Control within Educational Technology

    Science.gov (United States)

    Karich, Abbey C.; Burns, Matthew K.; Maki, Kathrin E.

    2014-01-01

    Giving a student control over their learning has theoretical and intuitive appeal, but its effects are neither powerful nor consistent in the empirical literature base. This meta-analysis updated previous meta-analytic research by Niemiec, Sikorski, and Walberg by studying the overall effectiveness of providing learner control within educational…

  4. Highly Available DHTs : Keeping Data Consistency After Updates

    NARCIS (Netherlands)

    Knežević, Predrag; Wombacher, Andreas; Risse, Thomas; Despotovic, Zoran; Joseph, Sam; Sartori, Claudio

    2006-01-01

    The research in the paper is motivated by building a decentralized/P2P XML storage on top of a DHT (Distributed Hash Table). The storage must provide high data availability and support updates. High data availability in a DHT can be guaranteed by data replication. However, DHTs can not provide a

  5. Policy and practice in South African prisons: An update | Sloth ...

    African Journals Online (AJOL)

    Policy and practice in South African prisons: An update. Julia Sloth-Nielsen. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's ...

  6. Updated site compilation of the Latin American Pollen Database

    NARCIS (Netherlands)

    Flantua, S.G.A.; Hooghiemstra, H.; Grimm, E.C.; Behling, H.; Bush, M.B; González-Arrango, C.; Gosling, W.D.; Ledru, M.-P.; Lozano-Garciá, S.; Maldonado, A.; Prieto, A.R.; Rull, V.; van Boxel, J.H.

    2015-01-01

    The updated inventory of the Latin American Pollen Database (LAPD) offers a wide range of new insights. This paper presents a systematic compilation of palynological research in Latin America. A comprehensive inventory of publications in peer-reviewed and grey literature shows a major expansion of

  7. Revising and Updating the Inventory of Cross-Cultural Sensitivity

    Science.gov (United States)

    Mahon, Jennifer A.; Cushner, Kenneth

    2014-01-01

    The following article outlines research conducted to examine cross-cultural sensitivity in a sample of 949 incoming university students in the USA. The study was conducted during the process of updating an existing measure of cross-cultural sensitivity known as the Inventory of Cross-Cultural Sensitivity (ICCS), and to examine the various levels…

  8. On stochastic belief revision and update and their combination

    CSIR Research Space (South Africa)

    Rens, G

    2016-04-01

    Full Text Available International Workshop on Non-Monotonic Reasoning, 22-24 April 2016, Cape Town, South Africa On Stochastic Belief Revision and Update and their Combination Gavin Rens Centre for Artificial Intelligence Research, University of KwaZulu-Natal, School...

  9. Treatment of spasticity: an update

    OpenAIRE

    TEIVE, HÉLIO A.G.; ZONTA, MARISE; KUMAGAI, YUMI

    1998-01-01

    Apresentamos revisão sobre o tratamento atual da espasticidade, enfocando a terapêutica farmacológica, fisioterápica e através da utilização de toxina botulínica.We present an update about the treatment of spasticity, stressing the pharmacological treatment, physical therapy and botulinum toxin therapy.

  10. Treatability study sample exemption: update

    International Nuclear Information System (INIS)

    1997-01-01

    This document is a RCRA Information Brief intended to update the information in the 1991 Small-Scale Treatability Study Information Brief, and to address questions about the waste and treatability study sample exemptions that have arisen since References 3 and 5 were published

  11. Internet Journal of Medical Update

    African Journals Online (AJOL)

    Arun Kumar Agnihotri

    The two surveys on 'Gambling Addiction' published in this issue of the Internet Journal of. Medical Update recommend that there is a need to improve training of psychiatrists in India as regards identification, assessment and treatment of gambling addicts. I think the findings will inform the development and implementation of ...

  12. Financial Sector Assessment Update : Uganda

    OpenAIRE

    World Bank

    2005-01-01

    A joint International Monetary Fund-World Bank team conducted an assessment update of Uganda's financial system in connection with the Financial Sector Assessment Program (FSAP) in November, 2004. The purpose of the mission was to help the Ugandan authorities identify financial system strengths and weaknesses with a view to implementing an action plan to increase the system's contribution ...

  13. Upgrade trigger: Biannual performance update

    CERN Document Server

    Aaij, Roel; Couturier, Ben; Esen, Sevda; De Cian, Michel; De Vries, Jacco Andreas; Dziurda, Agnieszka; Fitzpatrick, Conor; Fontana, Marianna; Grillo, Lucia; Hasse, Christoph; Jones, Christopher Rob; Le Gac, Renaud; Matev, Rosen; Neufeld, Niko; Nikodem, Thomas; Polci, Francesco; Del Buono, Luigi; Quagliani, Renato; Schwemmer, Rainer; Seyfert, Paul; Stahl, Sascha; Szumlak, Tomasz; Vesterinen, Mika Anton; Wanczyk, Joanna; Williams, Mark Richard James; Yin, Hang; Zacharjasz, Emilia Anna

    2017-01-01

    This document presents the performance of the LHCb Upgrade trigger reconstruction sequence, incorporating changes to the underlying reconstruction algorithms and detector description since the Trigger and Online Upgrade TDR. An updated extrapolation is presented using the most recent example of an Event Filter Farm node.

  14. AMDIS and CHART update. 1

    Energy Technology Data Exchange (ETDEWEB)

    Murakami, I.; Kato, T. [National Inst. for Fusion Science, Toki, Gifu (Japan); Igarashi, A. [Miyazaki Univ., Miyazaki (JP)] [and others

    2002-10-01

    A working group for updating atomic and molecular collision data in the NIFS database AMDIS (electron scattering) and CHART (ion scattering) has been organized. This group has searched and reviewed literatures for collecting relevant atomic data with are to be included into the database. This is a summary report of the activities of this working group. (author)

  15. National Educators' Workshop: Update 1996

    Science.gov (United States)

    Gardner, James E.; Freeman, Ginger L.; Jacobs, James; Parkin, Don M.

    1997-01-01

    This document contains a collection of experiments presented and demonstrated at the National Educators' Workshop: Update 96, held at Los Alamos National Laboratory, Los Alamos, New Mexico on October 27-30, 1996. The experiments related to the nature and properties of engineering materials and provided information to assist in teaching about materials in the education community.

  16. Update of CERN exchange network

    CERN Multimedia

    2003-01-01

    An update of the CERN exchange network will be done next April. Disturbances or even interruptions of telephony services may occur from 4th to 24th April during evenings from 18:30 to 00:00 but will not exceed more than 4 consecutive hours (see tentative planning below). In addition, the voice messaging system will be shut down on March, 26th April from 18:00 to 00:00. Calls supposed to be routed to the voice messaging system will not be possible during the shutdown. CERN divisions are invited to avoid any change requests (set-ups, move or removals) of telephones and fax machines from 4th to 25th April. Everything will be done to minimize potential inconveniences which may occur during this update. There will be no loss of telephone functionalities. CERN GSM portable phones won't be affected by this change. Should you need more details, please send us your questions by email to Standard.Telephone@cern.ch. Date Change type Affected areas April 8 Update of switch in LHC 7 LHC 7 Point April 9 Update of...

  17. Update of CERN exchange network

    CERN Multimedia

    2003-01-01

    An update of the CERN exchange network will be done next April. Disturbances or even interruptions of telephony services may occur from 4th to 24th April during evenings from 18:30 to 00:00 but will not exceed more than 4 consecutive hours (see tentative planning below). In addition, the voice messaging system will be shut down on March, 26th April from 18:00 to 00:00. Calls supposed to be routed to the voice messaging system will not be possible during the shutdown. CERN divisions are invited to avoid any change requests (set-ups, move or removals) of telephones and fax machines from 4th to 25th April. Everything will be done to minimize potential inconveniences which may occur during this update. There will be no loss of telephone functionalities. CERN GSM portable phones won't be affected by this change. Should you need more details, please send us your questions by email to Standard.Telephone@cern.ch. DateChange typeAffected areas March 26Update of the voice messaging systemAll CERN sites April 4Updat...

  18. Wind turbine reliability database update.

    Energy Technology Data Exchange (ETDEWEB)

    Peters, Valerie A.; Hill, Roger Ray; Stinebaugh, Jennifer A.; Veers, Paul S.

    2009-03-01

    This report documents the status of the Sandia National Laboratories' Wind Plant Reliability Database. Included in this report are updates on the form and contents of the Database, which stems from a fivestep process of data partnerships, data definition and transfer, data formatting and normalization, analysis, and reporting. Selected observations are also reported.

  19. Nephrogenic systemic fibrosis: epidemiology update

    DEFF Research Database (Denmark)

    Marckmann, P.

    2008-01-01

    Purpose of review The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. Recent findings Epidemiological and histochemical studies demonstrated that gadoli...

  20. Model validation: Correlation for updating

    Indian Academy of Sciences (India)

    Department of Mechanical Engineering, Imperial College of Science, ... If we are unable to obtain a satisfactory degree of correlation between the initial theoretical model and the test data, then it is extremely unlikely that any form of model updating (correcting the model to match the test data) will succeed. Thus, a successful ...

  1. Archives: Internet Journal of Medical Update - EJOURNAL

    African Journals Online (AJOL)

    Items 1 - 23 of 23 ... Archives: Internet Journal of Medical Update - EJOURNAL. Journal Home > Archives: Internet Journal of Medical Update - EJOURNAL. Log in or Register to get access to full text downloads.

  2. Program Updates - San Antonio River Basin

    Science.gov (United States)

    This page will house updates for this urban waters partnership location. As projects progress, status updates can be posted here to reflect the ongoing work by partners in San Antonio working on the San Antonio River Basin.

  3. Sustainability Base Construction Update

    Science.gov (United States)

    Mewhinney, Michael

    2012-01-01

    Construction of the new Sustainability Base Collaborative support facility, expected to become the highest performing building in the federal government continues at NASA's Ames Research Center, Moffet Field, Calif. The new building is designed to achieve a platinum rating under the leadership in Energy and Environment Design (LEED) new construction standards for environmentally sustainable construction developed by the U. S. Green Building Council, Washington, D. C. When completed by the end of 2011, the $20.6 million building will feature near zero net energy consumption, use 90 percent less potable water than conventionally build buildings of equivalent size, and will result in reduced building maintenance costs.

  4. Teen pregnancy: an update.

    Science.gov (United States)

    McCracken, Katherine A; Loveless, Meredith

    2014-10-01

    To provide clinicians with a review of recent research and clinically applicable tools regarding teen pregnancy. Teen pregnancy rates have declined but still remain a significant problem in the USA. Teen pregnancy prevention was identified by Centers for Disease Control and Prevention as one of its top six priorities, which is increasing research and intervention data. Long-acting contraceptive methods are acceptable to teens and have been shown to reduce teen birth rates. Pregnant teens need special attention to counseling on pregnancy options and reducing risk during pregnancy with regular prenatal care. Postpartum teens should be encouraged and supported to breastfeed, monitored for depression, and have access to reliable contraception to avoid repeat undesired pregnancy. This review highlights important issues for all providers caring for female adolescents and those who may encounter teen pregnancy. Foremost prevention of teen pregnancy by comprehensive sexual education and access to contraception is the priority. Educating patients and healthcare providers about safety and efficacy of long-acting reversible contraception is a good step to reducing undesired teen pregnancies. Rates of postpartum depression are greater in adolescents than in adults, and adolescent mothers need to be screened and monitored for depression. Strategies to avoid another undesired pregnancy shortly after delivery should be implemented.

  5. Roll back malaria update.

    Science.gov (United States)

    1999-10-01

    This article presents the activities under WHO's Roll Back Malaria (RBM) program in Asia, particularly in Nepal, Indonesia, India, Bangladesh, Sri Lanka and the Philippines. In India, the RBM program will start in 5 districts with a major malaria problem. A national committee has been formed by researchers, which will be able to provide operational and strategic support and research expertise in relation to malaria. In Bangladesh, the RBM program was initiated in the sparsely populated hill tract areas of Banderban and Chittagong where access to health care is very poor. At the district level, effective partnerships with private practitioners, politicians, community leaders, school teachers, the press and district Ministry of Health officials are operating to plan for rolling back malaria. In Myanmar, Cambodia, Lao People's Democratic Republic, Yunnan province of China, Vietnam, and Thailand, the focus of the RBM program was to move health care closer to the malaria-infected communities. WHO¿s Global Health Leadership Fellowship Programme, supported by the UN Foundation and Rockefeller Foundation, enables potential leaders to experience the work of UN agencies and contribute to the work of the organization for 2 years. Three out of four persons appointed to the RBM program received prestigious awards: Dr. Paola Marchesini of Brazil; Dr. Tieman Diarra of Mali; and Dr. Bob Taylor of the UK.

  6. Update on Fresh Fuel Characterization of U-Mo Alloys

    Energy Technology Data Exchange (ETDEWEB)

    D. E. Burkes; D. M. Wachs; D. D. Keiser; M. A. Okuniewski; J. F. Jue; F. J. Rice; R. Prabhakaran

    2009-03-01

    The need to provide more accurate property information on U-Mo fuel alloys to operators, modellers, researchers, fabricators, and government increases as success of the GTRI Reactor Convert program continues. This presentation provides an update on fresh fuel characterization activities that have occurred at the INL since the RERTR 2008 conference in Washington, D.C. The update is particularly focused on properties recently obtained and on the development progress of new measurement techniques. Furthermore, areas where useful and necessary information is still lacking is discussed. The update deals with mechanical, physical, and microstructural properties for both integrated and separate effects. Appropriate discussion of fabrication characteristics, impurities, thermodynamic response, and effects on the topic areas are provided, along with a background on the characterization techniques used and developed to obtain the information. Efforts to measure similar characteristics on irradiated fuel plates are discussed.

  7. 75 FR 81037 - Waste Confidence Decision Update

    Science.gov (United States)

    2010-12-23

    ... NUCLEAR REGULATORY COMMISSION 10 CFR Part 51 [NRC-2008-0482] Waste Confidence Decision Update AGENCY: Nuclear Regulatory Commission. ACTION: Update and final revision of Waste Confidence Decision. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC or Commission) is updating its Waste Confidence...

  8. Androgenetic alopecia: An update

    Directory of Open Access Journals (Sweden)

    Feroze Kaliyadan

    2013-01-01

    Full Text Available Androgenetic alopecia (AGA is one of the commonest reasons for dermatological consultation. Over the last few years our understanding of the pathophysiology of AGA has improved and this has paved way for better diagnostic and therapeutic options. Recent research has dwelled on the role of stem cells in the pathophysiology of AGA and has also identified newer genetic basis for the condition. Dermoscopy/trichoscopy has emerged as a useful diagnostic tool for AGA. While the major treatment options continue to be topical minoxidil, systemic Finasteride and hair transplantations, newer modalities are under investigation. Specific diagnostic and treatment recommendations have also been developed on evidence based principles. This article reviews the recent concepts in relation to AGA. With regards to the pathophysiology we have tried to stress on recent knowledge of the molecular and genetic basis of AGA. We have emphasized on an evidence based approach for treatment and diagnosis.

  9. Updating the OMERACT filter

    DEFF Research Database (Denmark)

    Tugwell, Peter; Boers, Maarten; D'Agostino, Maria-Antonietta

    2014-01-01

    OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Filter provides guidelines for the development and validation of outcome measures for use in clinical research. The "Truth" section of the OMERACT Filter requires that criteria be met to demonstrate that the outcome instrument meets...... the criteria for content, face, and construct validity. METHODS: Discussion groups critically reviewed a variety of ways in which case studies of current OMERACT Working Groups complied with the Truth component of the Filter and what issues remained to be resolved. RESULTS: The case studies showed...... that there is broad agreement on criteria for meeting the Truth criteria through demonstration of content, face, and construct validity; however, several issues were identified that the Filter Working Group will need to address. CONCLUSION: These issues will require resolution to reach consensus on how Truth...

  10. JPSS CGS Tools For Rapid Algorithm Updates

    Science.gov (United States)

    Smith, D. C.; Grant, K. D.

    2011-12-01

    The National Oceanic and Atmospheric Administration (NOAA) and National Aeronautics and Space Administration (NASA) are jointly acquiring the next-generation civilian weather and environmental satellite system: the Joint Polar Satellite System (JPSS). JPSS will contribute the afternoon orbit component and ground processing system of the restructured National Polar-orbiting Operational Environmental Satellite System (NPOESS). As such, JPSS replaces the current Polar-orbiting Operational Environmental Satellites (POES) managed by NOAA and the ground processing component of both POES and the Defense Meteorological Satellite Program (DMSP) replacement known as the Defense Weather Satellite System (DWSS), managed by the Department of Defense (DoD). The JPSS satellites will carry a suite of sensors designed to collect meteorological, oceanographic, climatological, and solar-geophysical observations of the earth, atmosphere, and space. The ground processing system for JPSS is known as the JPSS Common Ground System (JPSS CGS), and consists of a Command, Control, and Communications Segment (C3S) and the Interface Data Processing Segment (IDPS). Both are developed by Raytheon Intelligence and Information Systems (IIS). The Interface Data Processing Segment will process NPOESS Preparatory Project, Joint Polar Satellite System and Defense Weather Satellite System satellite data to provide environmental data products to NOAA and DoD processing centers operated by the United States government. Under NPOESS, Northrop Grumman Aerospace Systems Algorithms and Data Products (A&DP) organization was responsible for the algorithms that produce the EDRs, including their quality aspects. For JPSS, that responsibility has transferred to NOAA's Center for Satellite Applications & Research (STAR). As the Calibration and Validation (Cal/Val) activities move forward following both the NPP launch and subsequent JPSS and DWSS launches, rapid algorithm updates may be required. Raytheon and

  11. NASA UAS Update

    Science.gov (United States)

    Bauer, Jeffrey Ervin; Mulac, Brenda Lynn

    2010-01-01

    Last year may prove to be a pivotal year for the National Aeronautics and Space Administration (NASA) in the Unmanned Aircraft Systems (UAS) arena, especially in relation to routine UAS access to airspace as NASA accepted an invitation to join the UAS Executive Committee (UAS ExCom). The UAS ExCom is a multi-agency, Federal executive-level committee comprised of the Federal Aviation Administration (FAA), Department of Defense (DoD), Department of Homeland Security (DHS), and NASA with the goals to: 1) Coordinate and align efforts between key Federal Government agencies to achieve routine safe federal public UAS operations in the National Airspace System (NAS); 2) Coordinate and prioritize technical, procedural, regulatory, and policy solutions needed to deliver incremental capabilities; 3) Develop a plan to accommodate the larger stakeholder community at the appropriate time; and 4) Resolve conflicts between Federal Government agencies (FAA, DoD, DHS, and NASA), related to the above goals. The committee was formed in recognition of the need of UAS operated by these agencies to access to the National Airspace System (NAS) to support operational, training, development and research requirements. In order to meet that need, technical, procedural, regulatory, and policy solutions are required to deliver incremental capabilities leading to routine access. The formation of the UAS ExCom is significant in that it represents a tangible commitment by FAA senior leadership to address the UAS access challenge. While the focus of the ExCom is government owned and operated UAS, civil UAS operations are bound to benefit by the progress made in achieving routine access for government UAS. As the UAS ExCom was forming, NASA's Aeronautics Research Mission Directorate began to show renewed interest in UAS, particularly in relation to the future state of the air transportation system under the Next Generation Air Transportation System (NextGen). NASA made funding from the American

  12. Endocrine Dysregulation in Anorexia Nervosa Update

    Science.gov (United States)

    2011-01-01

    Context: Anorexia nervosa is a primary psychiatric disorder with serious endocrine consequences, including dysregulation of the gonadal, adrenal, and GH axes, and severe bone loss. This Update reviews recent advances in the understanding of the endocrine dysregulation observed in this state of chronic starvation, as well as the mechanisms underlying the disease itself. Evidence Acquisition: Findings of this update are based on a PubMed search and the author's knowledge of this field. Evidence Synthesis: Recent studies have provided insights into the mechanisms underlying endocrine dysregulation in states of chronic starvation as well as the etiology of anorexia nervosa itself. This includes a more complex understanding of the pathophysiologic bases of hypogonadism, hypercortisolemia, GH resistance, appetite regulation, and bone loss. Nevertheless, the etiology of the disease remains largely unknown, and effective therapies for the endocrine complications and for the disease itself are lacking. Conclusions: Despite significant progress in the field, further research is needed to elucidate the mechanisms underlying the development of anorexia nervosa and its endocrine complications. Such investigations promise to yield important advances in the therapeutic approach to this disease as well as to the understanding of the regulation of endocrine function, skeletal biology, and appetite regulation. PMID:21976742

  13. Update on fibromyalgia

    Directory of Open Access Journals (Sweden)

    Fabiola Atzeni

    2012-01-01

    Full Text Available IntroductionFibromyalgia (FM is a chronic pain syndrome characterized by widespread pain, fatigue, sleep alterations, and distress. It affects at least 2% of the adult population. The etiology of FM is not completely understood, and the syndrome is influenced by stress, physical illness, and a variety of pain conditions. Emerging evidence indicates that augmented pain processing within the central nervous system plays a primary role in the pathophysiology of this disorder. Diagnosis may be difficult because of the multifaceted nature of the syndrome and its overlap with other chronically painful conditions. This article reviews the most recent data in the literature on FM.Materials and methodsThere are currently no instrumental tests or specific diagnostic markers for FM. In fact, many of the existing indicators are regarded as significant for research purposes only.ResultsDifferential diagnosis requires an extensive clinical examination and complete patient history. Chest-X-rays and abdominal ultrasonography are the first steps in the general evaluation of a patient with suspected FM.ConclusionsA variety of pharmacological treatments have been used to treat FM, including antidepressants, nonsteroidal anti-inflammatory drugs, opioids, sedatives, muscle relaxants, and antiepileptics. Physical exercise and multimodal cognitive-behavioral therapy seem to be the most widely accepted and beneficial forms of non-pharmacological therapy.

  14. Updates in pediatric nutrition.

    Science.gov (United States)

    Oken, E; Lightdale, J R

    2001-06-01

    Ongoing research in several areas of pediatric nutrition has new practical applications for community-based pediatricians. For example, a fresh understanding of risk factors for rickets persuades pediatricians to recognize and treat this disease, which was thought to be nearly extinct in the modern industrialized world. Similarly, an expanded awareness of the antibacterial components of breast milk encourages a more complete dialogue between pediatricians and new mothers about the potential benefits of breast-feeding. For those infants with feeding intolerance, new data help to refine the indications for hypoallergenic formulas, which are increasingly recommended for children with a variety of symptoms. The past year also has seen breakthroughs in our understanding of supplemental nutrition for children. Vitamin A may provide direct benefits for the most vulnerable of children, namely premature infants at high risk for lung disease. At the other end of the pediatric spectrum, adolescent athletes seeking to enhance their performance are consuming poorly studied sports supplements that may not be beneficial and may even be toxic. Finally, a greater appreciation for the epidemic of obesity that is sweeping the United States and other countries suggests that children at high risk may represent a far more diverse population than had been recognized previously.

  15. Coxarthrosis - an update

    International Nuclear Information System (INIS)

    Imhof, H.; Noebauer-Huhmann, I.; Trattnig, S.

    2009-01-01

    Degenerative osteoarthritis of the hip joint (coxarthrosis) is the most common disease of the hip joint in adults. The diagnosis is based on a combination of radiographic findings and characteristic clinical symptoms. The lack of a radiographic consensus definition has seemingly resulted in a variation of the published incidences and prevalence of degenerative osteoarthritis of the hip joint. The chronological sequence of degeneration includes the following basic symptoms on conventional radiographs and CT: joint space narrowing, development of osteophytes, subchondral demineralisation/sclerosis and cyst formation, as well as loose bodies, joint malalignment and deformity. MR imaging allows additional visualization of early symptoms and/or activity signs such as cartilage edema, cartilage tears and defects, subchondral bone marrow edema, synovial edema and thickening, joint effusion and muscle atrophy. The scientific dispute concerns the significance of (minimal) joint malalignment (e.g. impingement, dysplasia etc.) and forms of malpositioning which as possible prearthrosis have a high probability of leading to degenerative osteoarthritis. Moreover, without any question, the preservation of joint containment and gender differences are important additional basic diagnostic principles, which have gained great interest in recent years. In research different MR procedures such as Na and H spectroscopy, T2*-mapping etc. with ultrahigh field MR allow cartilage metabolism and its changes in early degenerative osteoarthritis (''biochemical imaging'') to be studied. There is no doubt that even in a few years new profound knowledge is to be expected in this field. (orig.) [de

  16. Dental Anomalies: An Update

    Directory of Open Access Journals (Sweden)

    Fatemeh Jahanimoghadam

    2016-01-01

    Full Text Available Dental anomalies are usual congenital malformation that can happen either as isolated findings or as a part of a syndrome. Developmental anomalies influencing the morphology exists in both deciduous and permanent dentition and shows different forms such as gemination, fusion, concrescence, dilaceration, dens evaginatus (DE, enamel pearls, taurodontism or peg-shaped laterals. All These anomalies have clinical significance concerning aesthetics, malocclusion and more necessary preparing of the development of dental decays and oral diseases. Through a search in PubMed, Google, Scopus and Medline, a total of eighty original research papers during 1928-2016 were found with the keywords such as dental anomaly, syndrome, tooth and hypodontia. One hundred review titles were identified, eighty reviews were retrieved that were finally included as being relevant and of sufficient quality. In this review, dental anomalies including gemination, fusion, concrescence, dilaceration, dens invaginatus, DE, taurodontism, enamel pearls, fluorosis, peg-shaped laterals, dentinal dysplasia, regional odontodysplasia and hypodontia are discussed. Diagnosing dental abnormality needs a thorough evaluation of the patient, involving a medical, dental, familial and clinical history. Clinical examination and radiographic evaluation and in some of the cases, specific laboratory tests are also needed. Developmental dental anomalies require careful examination and treatment planning. Where one anomaly is present, clinicians should suspect that other anomalies may also be present. Moreover, careful clinical and radiographical examination is required. Furthermore, more complex cases need multidisciplinary planning and treatment.

  17. [Resistant hypertension: An update].

    Science.gov (United States)

    Renna, N F

    2018-01-31

    An estimated 10% to 20% of hypertensive patients could be considered resistant to treatment (RH). These are patients who are not controlled using three drugs, at the maximum tolerated doses, including a diuretic, as well as those with high blood pressure controlled using four or more drugs. The term is used to identify patients that might benefit from special diagnostic and/or therapeutic consideration. The term 'refractory hypertension' has recently been proposed as a novel phenotype of antihypertensive failure. It refers to patients whose blood pressure cannot be controlled with maximum treatment. The first studies of this phenotype indicate that it is rare and affects less than 5% of patients with RH. Adherence to or compliance with medical treatment is key to defining resistant hypertension. Closer attention has been paid to clinical and experimental research since the first scientific statement for the diagnosis, assessment and treatment of RH from the American Heart Association, and in the European guidelines, was published in 2008. This review will set out the concepts relating to prevalence, prognosis and compliance and cover the latest developments on this subject. Copyright © 2018 SEH-LELHA. Publicado por Elsevier España, S.L.U. All rights reserved.

  18. Post-16 update

    Science.gov (United States)

    1999-11-01

    . Provided the tasks are well defined and the marking criteria are straightforward to apply, internally assessed work provides an opportunity for real positive achievement; students are able to control the task they set themselves, and have every opportunity to maximize their marks. In the past most syllabuses used the coursework simply to assess experimental and investigative skills, through a series of experiments or a practical investigation. Two of the new specifications have taken the opportunity to broaden the scope of coursework. The Edexcel Salters - Horners Advanced Physics AS course includes a report on a visit. Students must make a visit to an establishment where physics is in action, and then report on how physics is used there. The visit may be to a local garage, supermarket or hospital, but could use any other local resource - or indeed justify that trip to CERN. The location of the visit is limited only by the imagination of teachers and students. In the AS course of OCR Advancing Physics students must make a presentation about a material they have studied. The presentation may be a talk, a poster or even a series of web pages. This gives students the opportunity to demonstrate their key skills in communication alongside collecting some marks towards their AS in Physics. In the A2 year students develop their research skills further by producing a research report on a topic of their choice. Students must show how they can draw together ideas from different aspects of physics in discussing their chosen subject. These two developments lead the way in encouraging teachers and examiners to take physics out of the school laboratory and into the world. Mary Whitehouse

  19. [Preoperative fasting guidelines: an update].

    Science.gov (United States)

    López Muñoz, A C; Busto Aguirreurreta, N; Tomás Braulio, J

    2015-03-01

    Anesthesiology societies have issued various guidelines on preoperative fasting since 1990, not only to decrease the incidence of lung aspiration and anesthetic morbidity, but also to increase patient comfort prior to anesthesia. Some of these societies have been updating their guidelines, as such that, since 2010, we now have 2 evidence-based preoperative fasting guidelines available. In this article, an attempt is made to review these updated guidelines, as well as the current instructions for more controversial patients such as infants, the obese, and a particular type of ophthalmic surgery. Copyright © 2014 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.

  20. Post-16 update

    Science.gov (United States)

    1999-01-01

    . It requires good use of computers. Other examples: use modern imaging methods to teach information processing and optics; study `designer materials' to reflect both the inventiveness and the curiosity of physicists. Tell stories from fundamental efforts to understand the world: forces and motion, waves and photons, the structure of the Universe, a hint of relativity. The new AS course has to fit QCA criteria, but should also look beyond them to suggest how to shape the future of A-level physics. Jon Ogborn Director, Institute of Physics Post-16 Initiative The study of matter The study of matter is as central to pure physics as it is to technological applications. Currently Advanced GNVQ Science requires much more detailed knowledge of materials than most A-level courses. But in every case, what 16 - 19 year-old students experience is a rather dated study of engineering materials, with an emphasis on mechanical properties. Almost entirely absent is the notion of our new ability to design materials. Recently, new techniques of visualization, modelling the hierarchy of structures inside a material and simulating the resulting changes in properties, have all dramatically changed the nature of materials science. Post-16 physics courses should mention some new classes of materials responsible for major industrial and social changes. For example, let's look at `soft matter' such as polymers, liquid crystals and emulsions. These are the stuff of Nature, which we are only now learning to imitate. The continuing miniaturization of computer chips and sensors is based on functional properties - optical, electrical, thermal or magnetic. If students are to understand and perhaps later to contribute to developments such as these, they deserve a better introduction. Careful thinking needs to go into deciding what a basic course might entail. But what topic could be better suited to coursework in the form of student research? Teaching about matter in an up-to-date way may sound too

  1. Updating Recursive XML Views of Relations

    DEFF Research Database (Denmark)

    Choi, Byron; Cong, Gao; Fan, Wenfei

    2009-01-01

    This paper investigates the view update problem for XML views published from relational data. We consider XML views defined in terms of mappings directed by possibly recursive DTDs compressed into DAGs and stored in relations. We provide new techniques to efficiently support XML view updates...... specified in terms of XPath expressions with recursion and complex filters. The interaction between XPath recursion and DAG compression of XML views makes the analysis of the XML view update problem rather intriguing. Furthermore, many issues are still open even for relational view updates, and need...... to be explored. In response to these, on the XML side, we revise the notion of side effects and update semantics based on the semantics of XML views, and present effecient algorithms to translate XML updates to relational view updates. On the relational side, we propose a mild condition on SPJ views, and show...

  2. CSTT Update: Fuel Quality Analyzer

    Energy Technology Data Exchange (ETDEWEB)

    Brosha, Eric L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lujan, Roger W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Mukundan, Rangachary [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rockward, Tommy [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Romero, Christopher J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Williams, Stefan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Wilson, Mahlon S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2018-02-06

    These are slides from a presentation. The following topics are covered: project background (scope and approach), developing the prototype (timeline), update on intellectual property, analyzer comparisons (improving humidification, stabilizing the baseline, applying clean-up strategy, impact of ionomer content and improving clean-up), proposed operating mode, considerations for testing in real-world conditions (Gen 1 analyzer electronics development, testing partner identified, field trial planning), summary, and future work.

  3. Towards Dynamic Updates In AUTOSAR

    OpenAIRE

    Martorell , Hélène; Fabre , Jean-Charles; Roy , Matthieu; Valentin , Régis

    2013-01-01

    International audience; Vehicles are nowadays increasingly software-intensive.Current practice shows that the whole software system is tested, validated and then uploaded in ECUs in a monolithic fashion, before a vehicle is put in operation. Yet, adding speci c features or updates without restarting the full validation and upload procedure could yield to signi cant gains. Unfortunately, the AUTOSAR (AUTomotive Open System ARchitec- ture) standard does not include native support for software u...

  4. Atypical odontalgia--an update.

    Science.gov (United States)

    Patel, Seena B; Boros, Audrey L; Kumar, Satish K S

    2012-09-01

    Atypical odontalgia is a commonly misdiagnosed condition that frequently leads to unnecessary dental treatments such as extraction and endodontic therapy. These treatments often worsen the pain. Despite greater recognition and understanding of this condition, proper diagnosis and treatment remains a challenge. It is believed that atypical odontalgia is a neuropathic condition. This article updates the current understanding of the etiology and pathophysiology of atypical odontalgia, and provides appropriate diagnostic and management approaches for this condition.

  5. Update on Internet2 Activities

    Science.gov (United States)

    Yun, T. Charles

    [14 Feb 2003] I propose an overview talk/update on several Internet2 activities that might be of interest to the e-VLBI community including: End-to-End performance project (PiPES); national (American) fiber infrastructure (a.k.a. National Light Rail, FiberCo, etc.); request for interest in short-term, dedicated, test-labmdas (inside the US only at this point).

  6. Update of CERN exchange network

    CERN Multimedia

    2003-01-01

    An update of the CERN exchange network will be done next April. Disturbances or even interruptions of telephony services may occur from 4th to 24th April during evenings from 18:30 to 00:00 but will not exceed more than 4 consecutive hours (see tentative planning below). In addition, the voice messaging system will be shut down on March, 26th April from 18:00 to 00:00. Calls supposed to be routed to the voice messaging system will not be possible during the shutdown. CERN divisions are invited to avoid any change requests (set-ups, move or removals) of telephones and fax machines from 4th to 25th April. Everything will be done to minimize potential inconveniences which may occur during this update. There will be no loss of telephone functionalities. CERN GSM portable phones won't be affected by this change. Should you need more details, please send us your questions by email to Standard.Telephone@cern.ch. Date Change type Affected areas March 26 Update of the voice messaging system All CERN sites April...

  7. Environmental Chemistry Update

    Science.gov (United States)

    1995-08-01

    Human Health Effects of the Chernobyl DisasterIncreased Incidence of Thyroid CancerThe release of radioactivity from the famous explosion at the fission nuclear power reactor at Chernobyl eight years ago has resulted in a substantial increase in the incidence of thyroid cancer in children in the immediate area but no great increase in the incidence of childhood leukemia, tumors, or genetic defects. In the region of the Belarus republic closest to Chernobyl, the childhood thyroid cancer rate has reached over 100 cases per million children, compared to less than 3 per million in most countries. More than 500 children in Belarus and Ukraine have been diagnosed with this disease. The likely cause of the cancers is radioactivity from the isotope 131-I and perhaps 133-I released during the explosion (1). Lead PollutionAnalysis of snow in the Greenland ice sheet indicates rather high levels of lead pollution in air from 500 BC to AD 300 and AD 1000-1500. The earliest lead pollution was associated with mining in Greece and then mining by the Romans, especially in Spain. The later pollution was due mainly to lead and silver smelting in Germany (2). Detrimental Effect of Lead upon IQ in AustraliaStudies of children in Port Pirie, Australia have produced further evidence of the detrimental effect of lead upon IQ. The cumulative exposure to lead of the children from birth to age seven years was determined by analyzing for the element in their baby teeth (3). Ozone Hole PhenomenaThe AntarcticThe Antarctic ozone hole appeared earlier than usual in 1994; it was as large and as severe as the holes in 1992 and 1993. The region of severe depletion covered about 24 million square kilometers, which is approximately the size of North America (4). The Role of Nitric AcidOur knowledge of the role of nitric acid in the formation of ozone holes over polar areas has recently been improved by a joint publication from researchers in Scotland and the United States. Using data obtained by

  8. Validation, updating and impact of clinical prediction rules: a review.

    Science.gov (United States)

    Toll, D B; Janssen, K J M; Vergouwe, Y; Moons, K G M

    2008-11-01

    To provide an overview of the research steps that need to follow the development of diagnostic or prognostic prediction rules. These steps include validity assessment, updating (if necessary), and impact assessment of clinical prediction rules. Narrative review covering methodological and empirical prediction studies from primary and secondary care. In general, three types of validation of previously developed prediction rules can be distinguished: temporal, geographical, and domain validations. In case of poor validation, the validation data can be used to update or adjust the previously developed prediction rule to the new circumstances. These update methods differ in extensiveness, with the easiest method a change in model intercept to the outcome occurrence at hand. Prediction rules -- with or without updating -- showing good performance in (various) validation studies may subsequently be subjected to an impact study, to demonstrate whether they change physicians' decisions, improve clinically relevant process parameters, patient outcome, or reduce costs. Finally, whether a prediction rule is implemented successfully in clinical practice depends on several potential barriers to the use of the rule. The development of a diagnostic or prognostic prediction rule is just a first step. We reviewed important aspects of the subsequent steps in prediction research.

  9. The UCSC Genome Browser database: 2018 update.

    Science.gov (United States)

    Casper, Jonathan; Zweig, Ann S; Villarreal, Chris; Tyner, Cath; Speir, Matthew L; Rosenbloom, Kate R; Raney, Brian J; Lee, Christopher M; Lee, Brian T; Karolchik, Donna; Hinrichs, Angie S; Haeussler, Maximilian; Guruvadoo, Luvina; Navarro Gonzalez, Jairo; Gibson, David; Fiddes, Ian T; Eisenhart, Christopher; Diekhans, Mark; Clawson, Hiram; Barber, Galt P; Armstrong, Joel; Haussler, David; Kuhn, Robert M; Kent, W James

    2018-01-04

    The UCSC Genome Browser (https://genome.ucsc.edu) provides a web interface for exploring annotated genome assemblies. The assemblies and annotation tracks are updated on an ongoing basis-12 assemblies and more than 28 tracks were added in the past year. Two recent additions are a display of CRISPR/Cas9 guide sequences and an interactive navigator for gene interactions. Other upgrades from the past year include a command-line version of the Variant Annotation Integrator, support for Human Genome Variation Society variant nomenclature input and output, and a revised highlighting tool that now supports multiple simultaneous regions and colors. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  10. Updates in fetal spina bifida repair.

    Science.gov (United States)

    Blumenfeld, Yair J; Belfort, Michael A

    2018-04-01

    To examine updates in fetal spina bifida surgical repair, as well as promising results emerging from translational medicine. Although the Management of Myelomeningocele Study sponsored by the National Institutes of Health helped establish the neonatal benefits of prenatal spina bifida repair via uterine hysterotomy, also known as 'open' fetal surgery, fetoscopic approaches may yield better maternal and obstetric outcomes. Spina bifida is a severe congenital malformation associated with significant neonatal and childhood morbidity and mortality. Although 'open' fetal spina bifida repair has become the standard prenatal surgical approach due to proven neonatal benefit, this approach is associated with significant maternal and obstetric risks. Recent developments from multidisciplinary clinical and translational research have highlighted the potential for novel fetoscopic surgical approaches to decrease maternal morbidity and reduce obstetric risks. Moreover, novel stem cell therapies coupled with in-utero medical approaches targeting the pathophysiological pathways associated with spina bifida are likely to make additional significant impact.

  11. Saliva in forensic odontology: A comprehensive update.

    Science.gov (United States)

    Saxena, Susmita; Kumar, Sanjeev

    2015-01-01

    In recent years, saliva has attracted much interest among researchers especially in the field of forensic sciences. This complex body fluid is gaining popularity due to its ease of collection, safety in handling and its close relationship with plasma. Analysis of saliva for serological testing and cellular content has proved to be of wide use in crime detection, drug and alcohol abuse, hormone identification, cases of poisoning and animal bites. There is a need for forensic laboratories to automate the settings specific for saliva as routinely done for blood or urine in order to consider saliva as the primary investigating tool in the absence of other body fluids. This update is aimed at highlighting the many uses of saliva in the practice of forensic odontology.

  12. Teaching and researching

    CERN Document Server

    Grabe, William

    2013-01-01

    Teaching and Researching Reading was first written to help language professionals understand the complex nature of reading. Now in a thoroughly updated and improved second edition, the book expands connections from research on reading to instructional practices and teacher-initiated action research. Offering an updated overview of reading theory, it summarises key ideas and issues in first and second language contexts.In addition to providing insightful research analyses, Grabe and Stoller offer practical advice for practitioners and researchers, including evidence-based teaching ideas and a m

  13. Updated Colombian Seismic Hazard Map

    Science.gov (United States)

    Eraso, J.; Arcila, M.; Romero, J.; Dimate, C.; Bermúdez, M. L.; Alvarado, C.

    2013-05-01

    possible to determinate environments and scenarios where the seismic hazard is a function of distance and magnitude and also the principal seismic sources that contribute to the seismic hazard at each site (dissagregation). This project was conducted by the Servicio Geológico Colombiano (Colombian Geological Survey) and the Universidad Nacional de Colombia (National University of Colombia), with the collaboration of national and foreign experts and the National System of Prevention and Attention of Disaster (SNPAD). It is important to stand out that this new seismic hazard map was used in the updated national building code (NSR-10). A new process is ongoing in order to improve and present the Seismic Hazard Map in terms of intensity. This require new knowledge in site effects, in both local and regional scales, checking the existing and develop new acceleration to intensity relationships, in order to obtain results more understandable and useful for a wider range of users, not only in the engineering field, but also all the risk assessment and management institutions, research and general community.

  14. Energy research within the forest industry in Sweden and Finland. Update for the period 1996-2000; Skogsindustriell energiforskning i Sverige och Finland. Uppdatering av forskningslaeget 1996-2000

    Energy Technology Data Exchange (ETDEWEB)

    Norrstroem, Hans; Ahlroth, Mikael; Nordgren, Mats [AaF-IPK AB, Stockholm (Sweden)

    2001-02-01

    This report is a summary of the energy research conducted in Sweden and Finland during the years 1996-2000 with relevance to the forest industry. The main research topics are gasification of biomass, waste products and black liquor, combustion in fluidized beds and drying technology. Another recent topic is system studies from a national perspective to investigate the long term impact of various factors relevant to the industry like recycled paper and CO-mitigation.

  15. Nordic MCL2 trial update

    DEFF Research Database (Denmark)

    Geisler, Christian H; Kolstad, Arne; Laurell, Anna

    2012-01-01

    Mantle cell lymphoma (MCL) is a heterogenic non-Hodgkin lymphoma entity, with a median survival of about 5 years. In 2008 we reported the early - based on the median observation time of 4 years - results of the Nordic Lymphoma Group MCL2 study of frontline intensive induction immunochemotherapy...... and autologous stem cell transplantation (ASCT), with more than 60% event-free survival at 5 years, and no subsequent relapses reported. Here we present an update after a median observation time of 6·5 years. The overall results are still excellent, with median overall survival and response duration longer than...

  16. Update in Infectious Diseases 2017.

    Science.gov (United States)

    Candel, F J; Peñuelas, M; Lejárraga, C; Emilov, T; Rico, C; Díaz, I; Lázaro, C; Viñuela-Prieto, J M; Matesanz, M

    2017-09-01

    Antimicrobial resistance in complex models of continuous infection is a current issue. The update 2017 course addresses about microbiological, epidemiological and clinical aspects useful for a current approach to infectious disease. During the last year, nosocomial pneumonia approach guides, recommendations for management of yeast and filamentous fungal infections, review papers on the empirical approach to peritonitis and extensive guidelines on stewardship have been published. HIV infection is being treated before and more intensively. The implementation of molecular biology, spectrometry and inmunology to traditional techniques of staining and culture achieve a better and faster microbiological diagnosis. Finally, the infection is increasingly integrated, assessing non-antibiotic aspects in the treatment.

  17. Big bang nucleosynthesis: An update

    Energy Technology Data Exchange (ETDEWEB)

    Olive, Keith A. [William I. Fine Theoretical Physics Institute, School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455 (United States)

    2013-07-23

    An update on the standard model of big bang nucleosynthesis (BBN) is presented. With the value of the baryon-tophoton ratio determined to high precision by WMAP, standard BBN is a parameter-free theory. In this context, the theoretical prediction for the abundances of D, {sup 4}He, and {sup 7}Li is discussed and compared to their observational determination. While concordance for D and {sup 4}He is satisfactory, the prediction for {sup 7}Li exceeds the observational determination by a factor of about four. Possible solutions to this problem are discussed.

  18. Primary Anorectal Melanoma: An Update

    Directory of Open Access Journals (Sweden)

    P Carcoforo, M.T Raiji, G.M Palini, M Pedriali, U Maestroni, G Soliani, A Detroia, M.V Zanzi, A.L Manna, J.G Crompton, R.C Langan, A Stojadinovic, I Avital

    2012-01-01

    Full Text Available The anorectum is a rare anatomic location for primary melanoma. Mucosal melanoma is a distinct biological and clinical entity from the more common cutaneous melanoma. It portrays worse prognosis than cutaneous melanoma, with distant metastases being the overwhelming cause of morbidity and mortality. Surgery is the treatment of choice, but significant controversy exists over the extent of surgical resection. We present an update on the state of the art of anorectal mucosal melanoma. To illustrate the multimodality approach to anorectal melanoma, we present a typical patient.

  19. Communication technology update and fundamentals

    CERN Document Server

    Grant, August E

    2014-01-01

    A classic now in its 14th edition, Communication Technology Update and Fundamentals is the single best resource for students and professionals looking to brush up on how these technologies have developed, grown, and converged, as well as what's in store for the future. It begins by developing the communication technology framework-the history, ecosystem, and structure-then delves into each type of technology, including everything from mass media, to computers and consumer electronics, to networking technologies. Each chapter is written by faculty and industry experts who p

  20. Cushing syndrome: update on testing.

    Science.gov (United States)

    Raff, Hershel

    2015-03-01

    Endogenous hypercortisolism (Cushing syndrome) is one of the most enigmatic diseases in clinical medicine. The diagnosis and differential diagnosis of Cushing syndrome depend on proper laboratory evaluation. In this review, an update is provided on selected critical issues in the diagnosis and differential diagnosis of Cushing syndrome: the use of late-night salivary cortisol in initial diagnosis and for postoperative surveillance, and the use of prolactin measurement to improve the performance of inferior petrosal sinus sampling to distinguish Cushing disease from ectopic adrenocorticotropic hormone (ACTH) syndrome during differential diagnosis of ACTH-dependent Cushing syndrome. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. Neurobiology of emotions: an update.

    Science.gov (United States)

    Esperidião-Antonio, Vanderson; Majeski-Colombo, Marilia; Toledo-Monteverde, Diana; Moraes-Martins, Glaciele; Fernandes, Juliana José; Bauchiglioni de Assis, Marjorie; Montenegro, Stefânia; Siqueira-Batista, Rodrigo

    2017-06-01

    The 'nature' of emotions is one of the archaic themes of Western thought, thematized in different cultural manifestations - such as art, science, philosophy, myths and religion -, since Ancient times. In the last decades, the advances in neurosciences have permitted the construction of hypotheses that explain emotions, especially through the studies involving the limbic system. To present an updated discussion about the neurobiology of processes relating to emotions - focusing (1) on the main neural structures that relate to emotions, (2) the paths and circuits of greater relevance, (3) the implicated neurotransmitters, (4) the connections that possess neurovegetative control and (5) the discussion about the main emotions - is the objective of this present article.

  2. Research Research

    African Journals Online (AJOL)

    Research. May 2014, Vol. 6, No. 1 AJHPE 33. Research. Currently, radiography students are faced with the challenge of having to learn factual information, while ... A descriptive exploratory research design was used to collect both ..... Creswell J. Research Design: Quantitative, Qualitative and Mixed Methods Approaches.

  3. Update on an Interstellar Asteroid

    Science.gov (United States)

    Kohler, Susanna

    2018-01-01

    Whats the news coming from the research world on the interstellar asteroid visitor, asteroid 1I/Oumuamua? Read on for an update from a few of the latest studies.What is Oumuamua?In lateOctober2017, the discovery of minor planet 1I/Oumuamua was announced. This body which researchers first labeled asa comet and later revised to an asteroid had just zipped around the Sun and was already in the process of speeding away whenwe trained our telescopes on it. Its trajectory, however, marked it as being a visitor from outside our solar system: the first knownvisitorof its kind.Since Oumuamuasdiscovery, scientists have been gathering as many observations of this bodyas possible before it vanishes into the distance. Simultaneously, theorists have leapt at the opportunity to explain its presence and the implications its passage has on our understanding of our surroundings. Here we present just a few of the latest studies that have been published on this first detected interstellar asteroid including several timelystudies published in our new journal, Research Notes of the AAS.The galactic velocity of Oumuamua does not coincide with any of the nearest stars to us. [Mamajek 2018]Where Did Oumuamua Come From?Are we sure Oumuamua didnt originate in our solar system andget scattered into a weird orbit? Jason Wright (The Pennsylvania State University) demonstrates via a series of calculations that no known solar system body could have scattered Oumuamua onto its current orbit nor could any stillunknown object bound to our solar system.Eric Mamajek (Caltech and University of Rochester) showsthat thekinematics of Oumuamua areconsistent with what we might expect of interstellar field objects, though he argues that its kinematics suggest its unlikely to have originated from many of the neareststellar systems.What AreOumuamuas Properties?Oumuamuas light curve. [Bannister et al. 2017]A team of University of Maryland scientists led by Matthew Knight captured a light curve of Oumuamua using

  4. The updated billion-ton resource assessment

    Science.gov (United States)

    Anthony Turhollow; Robert Perlack; Laurence Eaton; Matthew Langholtz; Craig Brandt; Mark Downing; Lynn Wright; Kenneth Skog; Chad Hellwinckel; Bryce Stokes; Patricia Lebow

    2014-01-01

    This paper summarizes the results of an update to a resource assessment, published in 2005, commonly referred to as the Billion-Ton Study (BTS). The updated results are consistent with the 2005 BTS in terms of overall magnitude. The 2005 BTS projected between 860 and 1240 Tg of biomass available in the 2050 timeframe, while the Billion-Ton Update (BT2), for a price of...

  5. The Center for Astronomy Education (CAE) and Our NSF Funded CCLI Phase III Collaboration of Astronomy Teaching Scholars (CATS) Program: Updates to Our New Community-Based Model for Astronomy Education Research

    Science.gov (United States)

    Brissenden, Gina; Impey, C.; Prather, E. E.; Lee, K. M.; CATS

    2010-01-01

    The Center for Astronomy Education (CAE) has been devoted to improving teaching & learning in Astro 101 by creating research-validated curriculum & assessment instruments for use in Astro 101 & by providing Astro 101 instructors professional development opportunities to increase their pedagogical content knowledge & instructional skills at implementing these curricula & assessment materials. To create sustainability and further expand this work, CAE, in collaboration with other national leaders in astronomy education & research, developed the Collaboration of Astronomy Teaching Scholars (CATS) Program. The primary goals of CATS are to: 1) increase the number of Astro 101 instructors conducting fundamental research in astronomy education 2) increase the amount of research-validated curriculum & assessment instruments available for use in Astro 101 3) increase the number of people prepared to develop & conduct their own CAE Teaching Excellence Workshops In our second year we have concluded a national study assessing the contribution students’ personal characteristics make to student learning gains and the effectiveness of interactive learning strategies. We have results from our classroom research validation study on the use of the "ClassAction” electronic learning system. We have begun creation of an assessment instrument designed specifically for Astro 101 to evaluate the effectiveness of our instruction in improving students’ attitudes & beliefs about science, and which is being informed by several of our studies and community input. We have also begun field-testing of our Solar System Concept Inventory. Additionally research into students’ beliefs and reasoning difficulties on topics in Cosmology is underway. We acknowledge the NSF for funding under Award No. 0715517, a CCLI Phase III Grant for the Collaboration of Astronomy Teaching Scholars (CATS) Program.

  6. Updated embrittlement trend curve for reactor pressure vessel steels

    International Nuclear Information System (INIS)

    Kirk, M.; Santos, C.; Eason, E.; Wright, J.; Odette, G.R.

    2003-01-01

    The reactor pressure vessels of commercial nuclear power plants are subject to embrittlement due to exposure to high energy neutrons from the core. Irradiation embrittlement of RPV belt-line materials is currently evaluated using US Regulatory Guide 1.99 Revision 2 (RG 1.99 Rev 2), which presents methods for estimating the Charpy transition temperature shift (ΔT30) at 30 ft-lb (41 J) and the drop in Charpy upper shelf energy (ΔUSE). A more recent embrittlement model, based on a broader database and more recent research results, is presented in NUREG/CR-6551. The objective of this paper is to describe the most recent update to the embrittlement model in NUREG/CR-6551, based upon additional data and increased understanding of embrittlement mechanisms. The updated ΔT30 and USE models include fluence, copper, nickel, phosphorous content, and product form; the ΔT30 model also includes coolant temperature, irradiation time (or flux), and a long-time term. The models were developed using multi-variable surface fitting techniques, understanding of the ΔT30 mechanisms, and engineering judgment. The updated ΔT30 model reduces scatter significantly relative to RG 1.99 Rev 2 on the currently available database for plates, forgings, and welds. This updated embrittlement trend curve will form the basis of revision 3 to Regulatory Guide 1.99. (author)

  7. Model Updating Nonlinear System Identification Toolbox Project

    Data.gov (United States)

    National Aeronautics and Space Administration — ZONA Technology (ZONA) proposes to develop an enhanced model updating nonlinear system identification (MUNSID) methodology that utilizes flight data with...

  8. Prevalence of fibromyalgia: literature review update.

    Science.gov (United States)

    Marques, Amelia Pasqual; Santo, Adriana de Sousa do Espírito; Berssaneti, Ana Assumpção; Matsutani, Luciana Akemi; Yuan, Susan Lee King

    The present study aimed to update the literature review on the prevalence of fibromyalgia published in 2006. A bibliographical survey was carried out from 2005 to 2014 in the MEDLINE, Web of Science, Embase, LILACS and SciELO databases and 3274 records were identified. Five researchers selected the studies, following the inclusion criteria: studies that obtained the prevalence of fibromyalgia. Fibromyalgia studies in associated diseases were excluded. When screening by title and abstract, 2073 irrelevant articles were excluded. The full texts of 210 articles were evaluated for eligibility and this review included 39 studies, described in 41 articles. The selected studies were grouped into four categories: (A) prevalence of fibromyalgia in the general population; (B) prevalence of fibromyalgia in women; (C) prevalence of fibromyalgia in rural and urban areas; (D) prevalence of fibromyalgia in special populations. The literature shows values of fibromyalgia prevalence in the general population between 0.2 and 6.6%, in women between 2.4 and 6.8%, in urban areas between 0.7 and 11.4%, in rural areas between 0.1 and 5.2%, and in special populations values between 0.6 and 15%. This literature review update shows a significant increase in fibromyalgia prevalence studies in the world. The new 2010 American College of Rheumatology criteria have not been widely used yet and the COPCORD (Community-oriented program for control of Rheumatic Diseases) methodology has increased the quality of studies on the prevalence of rheumatic diseases in general. Copyright © 2017 Elsevier Editora Ltda. All rights reserved.

  9. Prevalence of fibromyalgia: literature review update.

    Science.gov (United States)

    Marques, Amelia Pasqual; Santo, Adriana de Sousa do Espírito; Berssaneti, Ana Assumpção; Matsutani, Luciana Akemi; Yuan, Susan Lee King

    2016-12-18

    The present study aimed to update the literature review on the prevalence of fibromyalgia (FM) published in 2006. A bibliographical survey was carried out from 2005 to 2014 in the MEDLINE, Web of Science, Embase, LILACS and SciELO databases and 3274 records were identified. Five researchers selected the studies, following the inclusion criteria: studies that obtained the prevalence of FM. FM studies in associated diseases were excluded. When screening by title and abstract, 2073 irrelevant articles were excluded. The full texts of 210 articles were evaluated for eligibility and this review included 39 studies, described in 41 articles. The selected studies were grouped into four categories: a) prevalence of FM in the general population; B) prevalence of FM in women; C) prevalence of FM in rural and urban areas; D) prevalence of FM in special populations. The literature shows values of FM prevalence in the general population between 0.2 and 6.6%, in women between 2.4 and 6.8%, in urban areas between 0.7 and 11.4%, in rural areas between 0.1 and 5.2%, and in special populations values between 0.6 and 15%. This literature review update shows a significant increase in FM prevalence studies in the world. The new 2010 American College of Rheumatology criteria have not been widely used yet and the COPCORD (Community-oriented program for control of Rheumatic Diseases) methodology has increased the quality of studies on the prevalence of rheumatic diseases in general. Copyright © 2016. Published by Elsevier Editora Ltda.

  10. Energy Savings Potential and RD&D Opportunities for Commercial Building Appliances (2015 Update)

    Energy Technology Data Exchange (ETDEWEB)

    Goetzler, William [Navigant Consulting, Burlington, MA (United States); Guernsey, Matt [Navigant Consulting, Burlington, MA (United States); Foley, Kevin [Navigant Consulting, Burlington, MA (United States); Young, Jim [Navigant Consulting, Burlington, MA (United States); Chung, Greg [Navigant Consulting, Burlington, MA (United States)

    2016-06-01

    The Department of Energy commissioned a technology characterization and assessment of appliances used in commercial buildings for cooking, cleaning, water heating, and other end-uses. The primary objectives of this study were to document the energy consumed by commercial appliances and identify research, development, and demonstration opportunities to improve energy efficiency in each end-use. This report serves as an update to a 2009 report of the same name by incorporating updated data and sources where possible and updating the available technology options that provide opportunities for efficiency improvements.

  11. Does updating improve the methodological and reporting quality of systematic reviews?

    Directory of Open Access Journals (Sweden)

    Hamel Candyce

    2006-06-01

    Full Text Available Abstract Background Systematic reviews (SRs must be of high quality. The purpose of our research was to compare the methodological and reporting quality of original versus updated Cochrane SRs to determine whether updating had improved these two quality dimensions. Methods We identifed updated Cochrane SRs published in issue 4, 2002 of the Cochrane Library. We assessed the updated and original versions of the SRs using two instruments: the 10 item enhanced Overview Quality Assessment Questionnaire (OQAQ, and an 18-item reporting quality checklist and flow chart based upon the Quality of Reporting of Meta-analyses (QUOROM statement. At least two reviewers extracted data and assessed quality. We calculated the percentage (with a 95% confidence interval of 'yes' answers to each question. We calculated mean differences in percentage, 95% confidence intervals and p-values for each of the individual items and the overall methodological quality score of the updated and pre-updated versions using OQAQ. Results We assessed 53 SRs. There was no significant improvement in the global quality score of the OQAQ (mean difference 0.11 (-0.28; 0.70 p = 0.52. Updated reviews showed a significant improvement of 18.9 (7.2; 30.6 p Conclusion The overall quality of Cochrane SRs is fair-to-good. Although reporting quality improved on certain individual items there was no overall improvement seen with updating and methodological quality remained unchanged. Further improvement of quality of reporting is possible. There is room for improvement of methodological quality as well. Authors updating reviews should address identified methodological or reporting weaknesses. We recommend to give full attention to both quality domains when updating SRs.

  12. Researching research

    DEFF Research Database (Denmark)

    Pais, Alexandre; Valero, Paola

    2012-01-01

    We discuss contemporary theories in mathematics education in order to do research on research. Our strategy consists of analysing discursively and ideologically recent key publications addressing the role of theory in mathematics education research. We examine how the field fabricates its object...... of research by deploying Foucault’s notion of bio-politics - mainly to address the object “learning” - and Žižek’s ideology critique - to address the object “mathematics”. These theories, which have already been used in the field to research teaching and learning, have a great potential to contribute...... to a reflexivity of research on its discourses and effects. Furthermore, they enable us to present a clear distinction between what has been called the sociopolitical turn in mathematics education research and what we call a positioning of mathematics education (research) practices in the Political....

  13. Status of Hemlock in the Eastern United States.e-Science Update SRS–038

    Science.gov (United States)

    Randall S. Morin; Sonja N. Oswalt; Robert T. Trotter, III; Andrew M. Liebhold

    2011-01-01

    This science update provides an overview of the status and extent of the hemlock resource in the Eastern United States. The overview is based on inventories conducted by the Forest Inventory and Analysis (FIA) Programs at the Northern and Southern Research Stations, research conducted by scientists at the Northern Research Station, and pest surveys conducted by the...

  14. Non-Linear Approximation of Bayesian Update

    KAUST Repository

    Litvinenko, Alexander

    2016-06-23

    We develop a non-linear approximation of expensive Bayesian formula. This non-linear approximation is applied directly to Polynomial Chaos Coefficients. In this way, we avoid Monte Carlo sampling and sampling error. We can show that the famous Kalman Update formula is a particular case of this update.

  15. Census in Schools Educator Update, March 2009

    Science.gov (United States)

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1)…

  16. Better Plants Progress Update Fall 2013

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-09-23

    This Progress Update summarizes the significant energy saving achievements and cumulative cost savings made by these industry leaders from 2010-2012. The update also shares the plans and priorities over the next year for the Better Plants Program to continue to advance energy efficiency in the industrial sector.

  17. 34 CFR 668.55 - Updating information.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Updating information. 668.55 Section 668.55 Education... Information § 668.55 Updating information. (a)(1) Unless the provisions of paragraph (a)(2) or (a)(3) of this... applicant to verify the information contained in his or her application for assistance in an award year if...

  18. Control of Interference during Working Memory Updating

    Science.gov (United States)

    Szmalec, Arnaud; Verbruggen, Frederick; Vandierendonck, Andre; Kemps, Eva

    2011-01-01

    The current study examined the nature of the processes underlying working memory updating. In 4 experiments using the n-back paradigm, the authors demonstrate that continuous updating of items in working memory prevents strong binding of those items to their contexts in working memory, and hence leads to an increased susceptibility to proactive…

  19. Thematic outlook. Technical outlook for the fuel-cell research network (PACo). September 19, 2001 update, no. 1; Veille thematique. La veille technique pour le reseau PACo. Actualisation du 19 septembre 2001, no. 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-09-01

    This report brings together a compilation of abstracts of articles about some recent research works carried out in the domain of fuel cells, hydrogen production and hydrogen storage: dynamical behaviour of a PEM fuel cell for stationary applications; characterization of the Ballard's MK5-E PEMFC; modeling and analysis of a PEM system for transportation system applications; increase of the performances of a PEMFC by the optimization of the membrane and of the conditions of humidification; SOFC: exo-thermal reaction and heat source; average temperature SOFCs; performance and structure of a new CoO/Ni-based cathode for MCFC; choice of materials for fuel cell technology; recent trends of fuel cell-powered vehicles; hydrogen production in supercritical liquids for fuel cell use; on-board fuel conversion for fuel cells: comparison of the different fuels by numerical simulation; hydrogen production systems for fuel cells; reactor for the preferential catalytic oxidation of carbon monoxide (PROX) for PEMFC systems devoted to automotive vehicles; study of a gasoline reformer for fuel cell-powered vehicle applications; experimental research about hydrogen production from n-octane partial oxidation and vapo-reforming; simulation study of hydrogen storage in mono-sheet carbon nano-tubes; hydrogen adsorption in carbonized nano-structures; specific properties of the hydrogen engine; biomass power plants: a spectacular expansion in Germany. (J.S.)

  20. Brief update on endometriosis treatment

    Directory of Open Access Journals (Sweden)

    Moamar Al-Jefout

    2011-09-01

    Full Text Available Endometriosis is a chronic debilitating disease with features of chronic inflammation. Endometriosis is defined as the presence of endometrial like stroma and glands outside the uterine cavity (1. Medical professionals dealing with endometriosis face a lot of problems; in diagnosis, treatment and follow up of patients. Recent advances in molecular and clinical sciences offered a wide range of modalities for treatment. However, up to date there is no single very successful option for the ultimate treatment. In this review I have searched the literature using Medline, Pubmed, text books and other search engines to look for the most updated modalities for the treatment of endometriosis both surgical and medical ones. It seems to be that for fertility purposes surgical treatment followed by ART is the best available most beneficial way of dealing with endometriosis, while medical treatment is the best way to treat pain symptoms associated with endometriosis.

  1. [An update on myasthenia gravis].

    Science.gov (United States)

    Martínez Torre, S; Gómez Molinero, I; Martínez Girón, R

    2018-03-16

    Myasthenia gravis is one of the most common disorders that affect neuromuscular transmission. It is currently one of the most understood and characterised autoimmune disorders Its typical symptoms are fluctuating weakness and fatigue that affects a combination of ocular muscles, bulbar functions, as well as limb and respiratory muscles, which are due to an immune attack against the postsynaptic membrane of the neuromuscular junction. The diagnosis of myasthenia gravis is based on clinical and serological test. It is a disease that can be effectively controlled with the current therapeutic lines, even achieving a complete remission. An update of this interesting disorder is now presented. Copyright © 2018 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

  2. Papillomaviruses in ruminants: An update.

    Science.gov (United States)

    Daudt, C; Da Silva, F R C; Lunardi, M; Alves, C B D T; Weber, M N; Cibulski, S P; Alfieri, A F; Alfieri, A A; Canal, C W

    2018-03-30

    Papillomaviruses (PVs) are complex viruses which infect the skin or mucosae of a broad range of amniotes worldwide. They cause benign or malignant lesions depending on environmental factors, virus oncogenicity and the location of infection. Bovine papillomaviruses (BPVs) are the second most studied PVs beyond human PVs. In the past few years, genetic characterization of animal PVs has increased due to the availability of new techniques, which simplified the sequencing of entire genomes. Therefore, this review aims to provide an update of the current epidemiology, classification and genome features of ruminant PVs (mainly BPVs) affecting animals worldwide. The review also aimed to clarify the key differences between the high-risk Delta papillomaviruses and the seemingly low-risk Xi, Epsilon, Dyoxi and Dyokappapillomavirus as well as the recently described PVs BPV18, 19, 21 and PpuPV1 that belongs to an unclassified genus. © 2018 Blackwell Verlag GmbH.

  3. TWEAT '95: User's documentation update

    International Nuclear Information System (INIS)

    Robertus, B.; Lambert, R.

    1996-03-01

    This report is designed to be a supplement to TWEAT'94 (PVTD-C94-05.01K Rev.1). It is intended to describe the primary features of the Ternary Waste Envelope Assessment Tool software package that have been added in FY'95 and how to use them. It contains only minimal duplication of information found in TWEAT'94 even though all features of TWEAT'94 will still be available. Emphasis on this Update is the binary plotting capability and the OWL Import modifications. Like it's predecessors, this manual does not provide instructions for modifying the program code itself. The user of TWEAT'95 is expected to be familiar with the basic concepts and operation of the TWEAT software as discussed in TWEAT'94. Software and hardware requirements have not changed since TWEAT'94. TWEAT has now been tested using Macintosh System software versions 6.05 through 7.5

  4. Sprucing up the site - update

    CERN Multimedia

    2009-01-01

    As mentioned in a previous article the Bulletin will be publishing regular short updates following the consolidation work going on around the CERN sites: All internal lighting is being replaced in the office buildings on the Prevessin site. Work has started in building 866 and will move to 864 and 865 later. New energy-efficient lights are being installed, which will reduce electricity consumption by 30 -50%, and in the common areas like corridors the lighting will be switched on by motion sensors. Also in the Prevessin site, the lines in the car parks are being repainted. This will continue in the Meyrin site later. Work has started in Building 30 to completely refurbish the AT Auditorium.

  5. Thematic outlook. Technical outlook for the fuel-cell research network (PACo). March 13, 2002 update, no. 6; Veille thematique. La veille technique pour le reseau PACo. Actualisation du 13 mars 2002, no. 6

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-03-01

    This report brings together a compilation of abstracts of articles about some recent research works carried out in the domain of fuel cells and hydrogen production: 'giant jumps' in PEMFC technology from 1960 to the present day; SOFC systems: from 100 kW atmospheric systems to 300 kW pressurized systems; fields of application of PEM fuel cells on the energy market; numerical analysis of the production characteristics of a tubular SOFC with internal reforming; comparative study of the performances obtained with sulfonated poly(butadiene-styrene) membranes; non-planar architecture for PEM fuel cells; mass and heat transfer simulation inside a fuel cell for various channel sections; less expensive and more efficient fuel cells: the abatement of manufacturing costs can lead to products commercialization; comparison between fuel cell powered vehicles and future conventional vehicles; hydrogen produced from ethanol by indirect internal reforming in a MCFC system. (J.S.)

  6. Update on research and clinical translation on specific clinical areas: From bench to bedside: How insight in immune pathogenesis can lead to precision medicine of severe juvenile idiopathic arthritis.

    Science.gov (United States)

    Vastert, Sebastiaan; Prakken, Berent

    2014-04-01

    Despite the enormous progress in the treatment of juvenile idiopathic arthritis (JIA), innovations based on true bench-to-bedside research, performed in JIA patients, are still scarce. This chapter describes novel developments in which clinical innovations go hand in hand with basic discoveries. For the purpose of this review, we will mainly focus on developments in severe forms of JIA, most notably systemic JIA and polyarticular JIA. However, also in less severe forms of JIA, such as oligoarticular JIA, better insight will help to improve diagnosis and treatment. Facilitating the transition from bench to bedside will prove crucial for addressing the major challenges in JIA management. If successful, it will set new standards for a safe, targeted and personalized therapeutic approach for children with JIA. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Thematic outlook. Technical outlook for the fuel-cell research network (PACo). December 2001 update, no. 4; Veille thematique. La veille technique pour le reseau PACo. Actualisation de decembre 2001, no.4

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-12-01

    This report brings together a compilation of abstracts of articles about some recent research works carried out in the domain of fuel cells and hydrogen production: an overview of the technical and economical challenges of fuel cells; development of low temperature SOFCs; InDEC B.V. (Innovative Dutch Electro Ceramics) pilot production plant for planar SOFC components; sheet of conductive material with gaseous diffusion layer properties for fuel cells; catalytic properties of new anode materials for methane-fueled SOFCs; JRCM, Nippon Steel, NKK and Teikoku Sanso jointly develop the process of hydrogen extraction from coking plant gas; hydrogen production from vapo-reforming of vegetal oil in presence of nickel catalysts; performances of Pd and Pd/Ag membranes for a CO conversion reactor; on-board hydrogen production. (J.S.)

  8. 2013 Building America Research Planning Meeting Summary

    Energy Technology Data Exchange (ETDEWEB)

    Metzger, C. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hunt, S. [Confluence Communications, Missoula, MT (united States)

    2014-02-01

    The Building America Research Planning Meeting was held October 28-30, 2013, in Washington, DC. This meeting provides one opportunity each year for the research teams, national laboratories and Department of Energy (DOE) managers to meet in person to share the most pertinent information and collaboration updates. This report documents the presentations, highlights key program updates, and outlines next steps for the program.

  9. Thematic outlook: the technical outlook for the fuel cell research network (PACO). September 23, 2003 update no. 16; Veille thematique. La veille technique pour le reseau PACO. Actualisation du 23 septembre 2003, no. 16

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Summaries of several recent articles and patents are gathered here. They deal with fuel cells and hydrogen production and storage. Their different titles are given below: 1)the behaviour of the electrode potential in direct hydrazine fuels 2)a device of desalination fed with a fuel cell 3)experiment in the field of residential fuel cell systems at ECN (Energy Research Center) 4)'design of a divided feeding' for SOFC with an internal reforming system 5)water management and thermal management in a fuel cell vehicle fed with hydrogen extracted from sodium borohydride (NaBH{sub 4}) 6)a mathematical model of propulsion systems by PEMFC for mobile applications 7)assessment of the feasibility of a DMFC containing an alkaline membrane 8)semi-empirical assessment model of the performance of a DMFC, first part: development of the model and validation 9)PEMFC and the challenge of CO 10)materials for SOFC 11)natural gas and LPG desulfurization for fuel cells reformers 12)heat exchangers for reforming techniques 13)desulfurization of a fuel for fuel cell system 14)hydrogen production from solar thermal reactor 15)hydrogen physico-chemical storage: nano-structured storage materials having modified covalent bonds sp2. The references of these articles and patents are detailed. (O.M.)

  10. Thematic outlook: the technical survey for the fuel cell research network PACO. March 14, 2005 update no. 29; Veille thematique. La veille technique pour le reseau PACO. Actualisation du 14 mars 2005, no. 29

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    Summaries of several recent articles are gathered here. They deal with fuel cells and hydrogen production. Their different titles are given below: 1)thermodynamic analysis of a SOFC fed with ethanol and running in internal reforming mode 2)effect of the methanol and ethanol permeation on the efficiencies of a direct alcohol fuel cell with a PtRu/C anode 3)analysis of an hybrid SOFC micro-turbine micro-generation system 4)dynamic modelling and simulation of a small hybrid wind-fuel cell system 5)simulation of a system combining SOFC and PEMFC 6)assessment of the impacts and of the economical aspects of the fuel cell APU part 1: modelling of the cost and the efficiencies of the system part 2)impacts on the health and on the environment, analysis of the life cycle and optimization 7)efficiencies of vehicles equipped with direct hydrogen or reformed methanol PEMFC 8)methods for supplying fuel cell devices 9)auxiliary fuel cell system 10)analysis of life cycle of maritime applications of fuel cells 11)critical analysis of different hydrogen production and uses ways 12)comparison of the hydrogen and natural gas production processes in a thermodynamical and environmental point of view 13)research and development on the hydrogen production by high temperature electrolysis. The references of these articles are detailed. (O.M.)

  11. Thematic outlook. Technical outlook for the fuel-cell research network (PACo). August 8, 2002 update, no. 7; Veille thematique. La veille technique pour le reseau PACo. Actualisation du 8 aout 2002, no. 7

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-08-01

    This report brings together a compilation of abstracts of articles about some recent research works carried out in the domain of fuel cells, hydrogen production and hydrogen storage: characteristics of a PEM fuel cell submitted to a transient increase of CO concentration; perspectives of the different fuel cell technologies in transport applications; development of a portable fuel cell system for the soldier's equipment; direct 2-propanol low temperature fuel cell; a fuel cell system quasi-directly supplied with methanol and based on a mixture of electrolytic polymers; catalysis in low temperature fuel cells (part.1: the cathode stakes); manufacturing and performance of the new multi-layer cathodes for SOFCs; patent about intermediate plates for the limitation of the movement of the bolts used for the fastening of a fuel cell core; the Paul Sherrer institute is testing a zinc and synthetic gas production process that use solar energy, natural gas and zinc oxide; experimental evaluation of a combined plasma/catalyst system for the production of hydrogen from the partial oxidation of hydrocarbons; hydrogen production using a new chemo-organo-trophic bacteria: Citrobacter sp. Y19; hydrogen as energy vector: competition or complementarity with fossil fuels; hydrogen storage in general and in light monocrystalline metal hydrides in particular; the nuclear option for the production of hydrogen as energy of the future. (J.S.)

  12. Thematic outlook: the technical outlook for the fuel cell research network (PACO). December 22, 2003 update no. 19; Veille thematique. La veille technique pour le reseau PACO. Actualisation du 22 decembre 2003, no. 19

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Summaries of several recent articles and patents are gathered here. They deal with fuel cells, the means of transport, the hydrogen production and with the different new other energies. Their different titles are given below : 1)gas turbine/fuel cell arrangement 2)design and fabrication of a SOFC by CERAMIC FUEL CELLS 3)a 'microbial' fuel cell able of converting glucose in electricity with high yields and velocity 4)a hybrid system: combined cycle gas turbine - multi-stage SOFC 5)a SOFC as auxiliary generator of electricity in an aircraft 6)recent development results of fuel in the Juelich research center 7)state of development of the SOFC at Haldor Topsoe/Risoe 8)a cost/advantage analysis of 'clean cars': methodology and applications to the electric cars 9)the generation of current and heat in a aerostat 10)hydrogen free from CO, produced from bio-ethanol steam reforming on cobalt catalysts supported on ZnO. Effect of the metallic precursor 11)device and method based on the cyclic auto-thermal reforming 12)the ammonia, source of hydrogen for a hybrid system: alkaline fuel/battery 13)effect of the Nafion on the activity of Pt-Ru electrocatalysts for the methanol electro-oxidation 14)'VISION 21': an integration of systems based on coal. The references of these articles and patents are detailed. (O.M.)

  13. Thematic outlook. Technical outlook for the fuel-cell research network (PACo). June 15, 2001 update, no. 0; Veille thematique. La veille technique pour le reseau PACo. Actualisation du 15 juin 2001, no. 0

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-06-01

    This report brings together a compilation of abstracts of articles about some recent research works carried out in the domain of fuel cells, hydrogen production and hydrogen storage: effect of hydrogen on the magnetic properties of iron nano-crystalline particulates; smaller fuel cells; development of a 1 kW PEMFC; materials for low temperature SOFCs; development and operation of a 150 W DMFC; materials science and engineering: a key-technology for the commercialization of fuel cells; chemical and electrochemical behaviour of Ni-Ti in cathodic conditions as used in a MCFC; patent for stainless steel bipolar plates; development of proton conductive membranes for PEMFCs and DMFCs; development and characterization of acid-doped polymer mixtures (poly-benzimidazole/sulfonated poly-sulfone) used as fuel cell electrolyte; modification of a proton conductive membrane for the reduction of methanol diffusion in a DMFC; DMFC based on a new low cost nano-porous membrane; method for controlling the connexion between a fuel cell and a power grid; steam reforming of biomass-derived ethanol for hydrogen production devoted to fuel cells; hydrogen production by catalytic decomposition of methane; hydrogen storage. (J.S.)

  14. Design and development for updating national 1:50,000 topographic databases in China

    Directory of Open Access Journals (Sweden)

    CHEN Jun

    2010-02-01

    Full Text Available 1.1 Objective Map databases are irreplaceable national treasure of immense importance. Their currency referring to its consistency with respect to the real world plays a critical role in its value and applications. The continuous updating of map databases at 1:50,000 scales is a massive and difficult task for larger countries of the size of more than several million’s kilometer squares. This paper presents the research and technological development to support the national map updating at 1:50,000 scales in China, including the development of updating models and methods, production tools and systems for large-scale and rapid updating, as well as the design and implementation of the continuous updating workflow. 1.2 Methodology The updating of map databases is different than its original creation, and a number of new problems should be solved, such as change detection using latest multi-source data, incremental object revision and relation amendment. The methodology of this paper consists of the following three parts: 1 Examine the four key aspects of map database updating and develop basic updating models/methods, such as currentness-oriented integration of multi-resource data, completeness-based incremental change detection in the context of existing datasets, consistency-aware processing of updated data sets, and user-friendly propagation and services of updates. 2 Design and develop specific software tools and packages to support the large-scale updating production with high resolution imagery and large-scale data generalization, such as map generalization, GIS-supported change interpretation from imagery, DEM interpolation, image matching-based orthophoto generation, data control at different levels. 3 Design a national 1:50,000 databases updating strategy and its production workflow, including a full coverage updating pattern characterized by all element topographic data modeling, change detection in all related areas, and whole process

  15. Updated WHO guidance on safe abortion: health and human rights.

    Science.gov (United States)

    Erdman, Joanna N; DePiñeres, Teresa; Kismödi, Eszter

    2013-02-01

    Since its first publication in 2003, the World Health Organization's "Safe abortion: technical and policy guidance for health systems" has had an influence on abortion policy, law, and practice worldwide. To reflect significant developments in the clinical, service delivery, and human rights aspects of abortion care, the Guidance was updated in 2012. This article reviews select recommendations of the updated Guidance, highlighting 3 key themes that run throughout its chapters: evidence-based practice and assessment, human rights standards, and a pragmatic orientation to safe and accessible abortion care. These themes not only connect the chapters into a coherent whole. They reflect the research and advocacy efforts of a growing field in women's health and human rights. Copyright © 2012 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  16. Atopic dermatitis and skin allergies - update and outlook.

    Science.gov (United States)

    Wollenberg, A; Feichtner, K

    2013-12-01

    During the last few years, an impressive amount of experimental studies and clinical trials have dealt with a variety of distinct topics in allergic skin diseases - especially atopic dermatitis. In this update, we discuss selected recent data that provide relevant insights into clinical and pathophysiological aspects of allergic skin diseases or discuss promising targets and strategies for the future treatment of skin allergy. This includes aspects of barrier malfunction and inflammation as well as the interaction of the cutaneous immune system with the skin microbiome and diagnostic procedures for working up atopic dermatitis patients. Additionally, contact dermatitis, urticaria, and drug reactions are addressed in this review. This update summarizes novel evidence, highlighting current areas of uncertainties and debates that will stimulate scientific discussions and research activities in the field of atopic dermatitis and skin allergies in the future. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. Environmental Development Plan for Transportation Energy Conservation. FY 79 update

    Energy Technology Data Exchange (ETDEWEB)

    Singh, M. K.; Bernard, III, M. J.

    1978-12-15

    This is the first annual update of the Environment Development Plan (EDP) for the DOE Division of Transportation Energy Conservation program. It identifies the ecosystem, resource, physical environment, health, safety, and socioeconomic concerns associated with the division's transportation programs. These programs include the research, development, demonstration and assessment (RDD and A) of seventeen transportation technologies and several strategy and policy development and implementation projects. The transportation technologies projects deal with highway transport including electric vehicles, marine transport and pipeline transport. This EDP presents a research and assessment plan for resolving any potentially adverse environmental concerns stemming from these programs.

  18. "Research Tools": Tools for supporting research and publications

    OpenAIRE

    Ebrahim, Nader Ale

    2014-01-01

    Research Tools” can be defined as vehicles that broadly facilitate research and related activities. “Research Tools” enable researchers to collect, organize, analyze, visualize and publicized research outputs. Dr. Nader has collected over 700 tools that enable students to follow the correct path in research and to ultimately produce high-quality research outputs with more accuracy and efficiency. It is assembled as an interactive Web-based mind map, titled “Research Tools”, which is updated ...

  19. Updates in the American Heart Association guidelines for cardiopulmonary resuscitation and potential applications to veterinary patients.

    Science.gov (United States)

    Maton, Barbara L; Smarick, Sean D

    2012-04-01

    To review the updates in the American Heart Association (AHA) guidelines for cardiopulmonary resuscitation (CPR) and identify potential applications to veterinary patients. Cardiopulmonary arrest is common in veterinary emergency and critical care, and consensus guidelines are lacking. Human resuscitation guidelines are continually evolving as new clinical and experimental studies support updated recommendations. Synthesis of human, experimental animal model, and veterinary literature support the potential for updates and advancement in veterinary CPR practices. This review serves to highlight updates in the AHA guidelines for CPR and evaluate their application to small animal veterinary patients. Interventions identified will be evaluated for trans-species potential, raise questions regarding best resuscitation recommendations, and offer opportunities for further research to continue to advance veterinary CPR. The prognosis for any patient undergoing cardiopulmonary arrest remains guarded. © Veterinary Emergency and Critical Care Society 2012.

  20. Optimizing Key Updates in Sensor Networks

    DEFF Research Database (Denmark)

    Yuksel, Ender; Nielson, Hanne Riis; Nielson, Flemming

    2011-01-01

    Sensor networks offer the advantages of simple and low–resource communication. Nevertheless, security is of particular importance in many cases such as when sensitive data is communicated or tamper-resistance is required. Updating the security keys is one of the key points in security, which...... restrict the amount of data that may be exposed when a key is compromised. In this paper, we propose novel key update methods, and benefiting from stochastic model checking we propose a novel method for determining optimal key update strategies for custom network scenarios. We also present a case study...

  1. Updates on GMSCs treatment for autoimmune diseases.

    Science.gov (United States)

    Huang, Feng; Liu, Zhong-Min; Zheng, Song Guo

    2018-02-20

    Autoimmune disease is a refractory disease. Accumulating Evidence has revealed that the manipulation of mesenchymal stem cells may have the potential to control or even treat autoimmune diseases. Human gingiva-derived mesenchymal stem cells (GMSCs) are emerging as a new line of mesenchymal stem cells that have displayed some potential advantages in controlling and treating autoimmune diseases. In this review, we briefly update the current understanding on the biology of GMSCs and their effects on preventing and treating autoimmune diseases. The availability of gingival mesenchymal stem cells (GMSCs), together with their potent capacity of multi-directional differentiation and inflammatory modulation, making GMSCs an ideal subtype of MSCs in treating autoimmune disease. Our and other studies have launched the earliest appraisal on GMSCs and carried out a lot of biological researches. The clinical trial of GMSCs on patients with autoimmune diseases will further approve their therapeutic effects, as well as its cellular and molecular mechanisms. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  2. MARMOT update for oxide fuel modeling

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yongfeng [Idaho National Lab. (INL), Idaho Falls, ID (United States); Schwen, Daniel [Idaho National Lab. (INL), Idaho Falls, ID (United States); Chakraborty, Pritam [Idaho National Lab. (INL), Idaho Falls, ID (United States); Jiang, Chao [Idaho National Lab. (INL), Idaho Falls, ID (United States); Aagesen, Larry [Idaho National Lab. (INL), Idaho Falls, ID (United States); Ahmed, Karim [Idaho National Lab. (INL), Idaho Falls, ID (United States); Jiang, Wen [Idaho National Lab. (INL), Idaho Falls, ID (United States); Biner, Bulent [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bai, Xianming [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Tonks, Michael [Pennsylvania State Univ., University Park, PA (United States); Millett, Paul [Univ. of Arkansas, Fayetteville, AR (United States)

    2016-09-01

    This report summarizes the lower-length-scale research and development progresses in FY16 at Idaho National Laboratory in developing mechanistic materials models for oxide fuels, in parallel to the development of the MARMOT code which will be summarized in a separate report. This effort is a critical component of the microstructure based fuel performance modeling approach, supported by the Fuels Product Line in the Nuclear Energy Advanced Modeling and Simulation (NEAMS) program. The progresses can be classified into three categories: 1) development of materials models to be used in engineering scale fuel performance modeling regarding the effect of lattice defects on thermal conductivity, 2) development of modeling capabilities for mesoscale fuel behaviors including stage-3 gas release, grain growth, high burn-up structure, fracture and creep, and 3) improved understanding in material science by calculating the anisotropic grain boundary energies in UO$_2$ and obtaining thermodynamic data for solid fission products. Many of these topics are still under active development. They are updated in the report with proper amount of details. For some topics, separate reports are generated in parallel and so stated in the text. The accomplishments have led to better understanding of fuel behaviors and enhance capability of the MOOSE-BISON-MARMOT toolkit.

  3. Asthma in Hispanics. An 8-Year Update

    Science.gov (United States)

    Rosser, Franziska J.; Forno, Erick; Cooper, Philip J.

    2014-01-01

    This review provides an update on asthma in Hispanics, a diverse group tracing their ancestry to countries previously under Spanish rule. A marked variability in the prevalence and morbidity from asthma remains among Hispanic subgroups in the United States and Hispanic America. In the United States, Puerto Ricans and Mexican Americans have high and low burdens of asthma, respectively (the “Hispanic Paradox”). This wide divergence in asthma morbidity among Hispanic subgroups is multifactorial, likely reflecting the effects of known (secondhand tobacco smoke, air pollution, psychosocial stress, obesity, inadequate treatment) and potential (genetic variants, urbanization, vitamin D insufficiency, and eradication of parasitic infections) risk factors. Barriers to adequate asthma management in Hispanics include economic and educational disadvantages, lack of health insurance, and no access to or poor adherence with controller medications such as inhaled corticosteroids. Although considerable progress has been made in our understanding of asthma in Hispanic subgroups, many questions remain. Studies of asthma in Hispanic America should focus on environmental or lifestyle factors that are more relevant to asthma in this region (e.g., urbanization, air pollution, parasitism, and stress). In the United States, research studies should focus on risk factors that are known to or may diverge among Hispanic subgroups, including but not limited to epigenetic variation, prematurity, vitamin D level, diet, and stress. Clinical trials of culturally appropriate interventions that address multiple aspects of asthma management in Hispanic subgroups should be prioritized for funding. Ensuring high-quality healthcare for all remains a pillar of eliminating asthma disparities. PMID:24881937

  4. Management of syncope in adults: an update.

    Science.gov (United States)

    Chen, Lin Y; Benditt, David G; Shen, Win-Kuang

    2008-11-01

    Syncope is a clinical syndrome characterized by transient loss of consciousness and postural tone that is most often due to temporary and spontaneously self-terminating global cerebral hypoperfusion. A common presenting problem to health care systems, the management of syncope imposes a considerable socioeconomic burden. Clinical guidelines, such as the European Society of Cardiology Guidelines on Management of Syncope, have helped to streamline its management. In recent years, we have witnessed intensive efforts on many fronts to improve the evaluation process and to explore therapeutic options. For this update, we summarized recent active research in the following areas: the role of the syncope management unit and risk prediction rules in providing high-quality and cost-effective evaluation in the emergency department, the implementation of structured history taking and standardized guideline-based evaluation to improve diagnostic yield, the evolving role of the implantable loop recorder as a diagnostic test for unexplained syncope and for guiding management of neurally mediated syncope, and the shift toward nonpharmacological therapies as mainstay treatment for patients with neurally mediated syncope. Syncope is a multidisciplinary problem; future efforts to address critical issues, including the publication of clinical guidelines, should adopt a multidisciplinary approach.

  5. Obesity management: update on orlistat.

    Science.gov (United States)

    Drew, Belinda S; Dixon, Andrew F; Dixon, John B

    2007-01-01

    Over the past 20 years obesity has become a worldwide concern of frightening proportion. The World Health Organization estimates that there are over 400 million obese and over 1.6 billion overweight adults, a figure which is projected to almost double by 2015. This is not a disease restricted to adults - at least 20 million children under the age of 5 years were overweight in 2005 (WHO 2006). Overweight and obesity lead to serious health consequences including coronary artery disease, stroke, type-2 diabetes, heart failure, dyslipidemia, hypertension, reproductive and gastrointestinal cancers, gallstones, fatty liver disease, osteoarthritis and sleep apnea (Padwal et al 2003). Modest weight loss in the obese of between 5% and 10% of bodyweight is associated with improvements in cardiovascular risk profiles and reduced incidence of type 2 diabetes (Goldstein 1992; Avenell et al 2004; Padwal and Majumdar 2007). Orlistat, a gastric and pancreatic lipase inhibitor that reduces dietary fat absorption by approximately 30%, has been approved for use for around ten years (Zhi et al 1994; Hauptman 2000). There is now a growing body of evidence to suggest that Orlistat assists weight loss and that it may also have additional benefits. The aim of this review is to provide a brief update on the current literature studying the efficacy, safety and significance of the use of Orlistat in clinical practice.

  6. Vasectomy reversal: a clinical update

    Directory of Open Access Journals (Sweden)

    Abhishek P Patel

    2016-01-01

    Full Text Available Vasectomy is a safe and effective method of contraception used by 42-60 million men worldwide. Approximately 3%-6% of men opt for a vasectomy reversal due to the death of a child or divorce and remarriage, change in financial situation, desire for more children within the same marriage, or to alleviate the dreaded postvasectomy pain syndrome. Unlike vasectomy, vasectomy reversal is a much more technically challenging procedure that is performed only by a minority of urologists and places a larger financial strain on the patient since it is usually not covered by insurance. Interest in this procedure has increased since the operating microscope became available in the 1970s, which consequently led to improved patency and pregnancy rates following the procedure. In this clinical update, we discuss patient evaluation, variables that may influence reversal success rates, factors to consider in choosing to perform vasovasostomy versus vasoepididymostomy, and the usefulness of vasectomy reversal to alleviate postvasectomy pain syndrome. We also review the use of robotics for vasectomy reversal and other novel techniques and instrumentation that have emerged in recent years to aid in the success of this surgery.

  7. Updating neutrino magnetic moment constraints

    Directory of Open Access Journals (Sweden)

    B.C. Cañas

    2016-02-01

    Full Text Available In this paper we provide an updated analysis of the neutrino magnetic moments (NMMs, discussing both the constraints on the magnitudes of the three transition moments Λi and the role of the CP violating phases present both in the mixing matrix and in the NMM matrix. The scattering of solar neutrinos off electrons in Borexino provides the most stringent restrictions, due to its robust statistics and the low energies observed, below 1 MeV. Our new limit on the effective neutrino magnetic moment which follows from the most recent Borexino data is 3.1×10−11μB at 90% C.L. This corresponds to the individual transition magnetic moment constraints: |Λ1|≤5.6×10−11μB, |Λ2|≤4.0×10−11μB, and |Λ3|≤3.1×10−11μB (90% C.L., irrespective of any complex phase. Indeed, the incoherent admixture of neutrino mass eigenstates present in the solar flux makes Borexino insensitive to the Majorana phases present in the NMM matrix. For this reason we also provide a global analysis including the case of reactor and accelerator neutrino sources, presenting the resulting constraints for different values of the relevant CP phases. Improved reactor and accelerator neutrino experiments will be needed in order to underpin the full profile of the neutrino electromagnetic properties.

  8. The Updated Multiple Star Catalog

    Science.gov (United States)

    Tokovinin, Andrei

    2018-03-01

    The catalog of hierarchical stellar systems with three or more components is an update of the original 1997 version. For 2000 hierarchies, the new Multiple Star Catalog (MSC) provides distances, component masses and periods, and supplementary information (astrometry, photometry, identifiers, orbits, notes). The MSC content and format are explained, and its incompleteness and strong observational selection are stressed. Nevertheless, the MSC can be used for statistical studies and is a valuable source for planning observations of multiple stars. Rare classes of stellar hierarchies found in the MSC (with six or seven components, extremely eccentric orbits, planar and possibly resonant orbits, hosting planets) are briefly presented. High-order hierarchies have smaller velocity dispersion compared to triples and are often associated with moving groups. The paper concludes with an analysis of the ratio of periods and separations between inner and outer subsystems. In wide hierarchies, the ratio of semimajor axes, estimated statistically, is distributed between 3 and 300, with no evidence of dynamically unstable systems.

  9. Febrile seizures. Update and controversies.

    Science.gov (United States)

    Jan, Mohammed M; Girvin, John P

    2004-10-01

    Febrile seizures are the most common seizure disorder in children younger than 5 years of age. Most febrile seizures are brief, do not require any specific treatment or workup, and have benign prognoses. Generalists and pediatricians are frequently faced with anxious parents and are required to make rational decisions regarding the need to investigate and treat such a child. They subsequently need to provide further prognostic information and counseling to the families. The aim of this article is to provide an updated overview of febrile seizures and review the most recent diagnostic and therapeutic recommendations. Despite the progress in the understanding of this benign syndrome, a wide variation in physician evaluation and management persists. However, there is recent evidence that pediatricians are becoming more selective in admitting and investigating children with febrile seizures. Admitted children frequently had complex seizures, status epilepticus, or were ill looking. Considering the full scope of febrile seizures, the yield of investigations that might alter management remains low and does not justify extensive work-up or prolonged hospitalization.

  10. Extraglottic airway devices: technology update

    Directory of Open Access Journals (Sweden)

    Sharma B

    2017-08-01

    Full Text Available Bimla Sharma, Chand Sahai, Jayashree Sood Department of Anaesthesiology, Pain and Perioperative Medicine, Sir Ganga Ram Hospital, New Delhi, India Abstract: Extraglottic airway devices (EADs have revolutionized the field of airway management. The invention of the laryngeal mask airway was a game changer, and since then, there have been several innovations to improve the EADs in design, functionality, safety and construction material. These have ranged from changes in the shape of the mask, number of cuffs and material used, like rubber, polyvinylchloride and latex. Phthalates, which were added to the construction material in order to increase device flexibility, were later omitted when this chemical was found to have serious adverse reproductive outcomes. The various designs brought out by numerous companies manufacturing EADs resulted in the addition of several devices to the airway market. These airway devices were put to use, many of them with inadequate or no evidence base regarding their efficacy and safety. To reduce the possibility of compromising the safety of the patient, the Difficult Airway Society (DAS formed the Airway Device Evaluation Project Team (ADEPT to strengthen the evidence base for airway equipment and vet the new extraglottic devices. A preuse careful analysis of the design and structure may help in better understanding of the functionality of a particular device. In the meantime, the search for the ideal EAD continues. Keywords: extraglottic airway devices, laryngeal mask airway, other extraglottic airway devices, safety, technology update

  11. IDSA releases updated coccidioidomycosis guidelines

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2016-09-01

    Full Text Available No abstract available. Article truncated at 150 words. The Infectious Diseases Society of America (IDSA has released updated Guidelines for the Treatment of Coccidioidomycosis, also known as cocci or Valley Fever (1. Coccidioidomycosis is a fungal infection endemic to the southwestern United States and a common cause of pneumonia and pulmonary nodules in this area. However, the infection can disseminate systemically especially in immunocompromised hosts and certain ethnic populations resulting in a variety of pulmonary and extrapulmonary complications. In addition to recommendations for these complications, the new guidelines address management of special at-risk populations, preemptive management strategies in at-risk populations and after unintentional laboratory exposure. The guidelines also suggest shorter courses of antibiotics for hospitalized patients and more ambulatory treatment for most individuals who have contracted Valley Fever. The panel was led by John N. Galgiani, MD, director of the Valley Fever Center for Excellence at the University of Arizona Health Sciences. Galgiani led a panel of 16 ...

  12. Updating of the bovine neosporosis

    Directory of Open Access Journals (Sweden)

    Alexander Martínez Contreras

    2012-06-01

    Full Text Available In the fields of Medicine and bovine production, there is a wide variety of diseases affecting reproduction, in relation to the number of live births, the interval between births and open days, among others. Some of these diseases produce abortions and embryonic death, which explain the alteration of reproductive parameters. Many of these diseases have an infectious origin, such as parasites, bacteria, viruses and fungi, which are transmitted among animals. Besides, some of them have zoonotic features that generate problems to human health. Among these agents, the Neospora caninum, protozoan stands out. Its life cycle is fulfilled in several species of animals like the dog and the coyote. These two act as its definitive hosts and the cattle as its intermediary host. The Neospora caninum causes in the infected animals, reproductive disorders, clinical manifestations and decreased production which affects productivity of small, medium and large producers. Because of this, diagnostic techniques that allow understanding the epidemiological behavior of this disease have been developed. However in spite of being a major agent in the bovine reproductive health, few studies have been undertaken to determine the prevalence of this agent around the world. Therefore, the objective of this review was to collect updated information on the behavior of this parasite, targeting its epidemiology, its symptoms, its impact on production and the methods of its control and prevention.

  13. Diuretics: a review and update.

    Science.gov (United States)

    Roush, George C; Kaur, Ramdeep; Ernst, Michael E

    2014-01-01

    Diuretics have been recommended as first-line treatment of hypertension and are also valuable in the management of hypervolemia and electrolyte disorders. This review summarizes the key features of the most commonly used diuretics. We then provide an update of clinical trials for diuretics during the past 5 years. Compared to other classes of medications, thiazide diuretics are at least as effective in reducing cardiovascular events (CVEs) in patients with hypertension and are more effective than β-blockers and angiotensin-converting enzyme inhibitors in reducing stroke. Observational cohort data and a network analysis have shown that CVEs are lowered by one-fifth from chlorthalidone when compared to the commonly used thiazide, hydrochlorothiazide. Relative to placebo, chlorthalidone increases life expectancy. In those aged 80 years and older, the diuretic, indapamide, lowers CVEs relative to placebo. The aldosterone antagonist, eplerenone, lowers total mortality in early congestive heart failure. The benefit of eplerenone following acute myocardial infarction (MI) is limited to administration within 3 to 6 days post-MI. Aldosterone antagonists have been shown to lower the incidence of sudden cardiac death and to reduce proteinuria. In the setting of heart failure, long acting loop diuretics azosemide and torasemide are more effective in improving heart failure outcomes than the far more commonly used short acting furosemide. Evening dosing of diuretics appears to lower CVEs relative to morning dosing. In conclusion, diuretics are a diverse class of drugs that remain extremely important in the management of hypertension and hypervolemic states.

  14. Hypersensitivity and vaccines: an update.

    Science.gov (United States)

    Barbaud, Annick; Deschildre, Antoine; Waton, Julie; Raison-Peyron, Nadia; Tréchot, Philippe

    2013-04-01

    Allergic reactions to vaccines can be classified as sensitivity to one of the vaccine components, pseudo-allergic reactions, often after hyperimmunization, and exacerbation of atopic symptoms or vasculitis. Pseudo-allergic reactions, some possibly due to hyperimmunization, are probably more common than true allergies. Atopic reactions should not be confused with the "flash" phenomenon, defined as an exacerbation of an allergic reaction due to a reduction in the allergic reactivity threshold following the vaccine injection. BCGitis occurs frequently, and for this reason, guidelines for Bacillus Calmette-Guérin (BCG) have been modified. The vaccine is now reserved for people at risk of exposure to Mycobacterium tuberculosis. This review provides an update on the vaccination modalities for people allergic to eggs, on the assessment that should be performed when a reaction occurs due to tetanus vaccination, on the urticaria after hepatitis vaccination, on an aluminum granuloma, which is more and more frequent in young children, and vasculitis after flu vaccination and BCGitis. The side effects associated with new, recently released vaccines, such as anti-influenza A H1N1 or anti-human papilloma virus (HPV) will also be presented.

  15. Passive Nuclear Plants Program (UPDATE)

    International Nuclear Information System (INIS)

    Chimeno, M. A.

    1998-01-01

    The light water passive plants program (PCNP), today Advanced Nuclear Power Plants Program (PCNA), was constituted in order to reach the goals of the Spanish Electrical Sector in the field of advanced nuclear power plants, optimize the efforts of all Spanish initiatives, and increase joint presence in international projects. The last update of this program, featured in revision 5th of the Program Report, reflects the consolidation of the Spanish sector's presence in International programs of the advanced power plants on the basis of the practically concluded American ALWR program. Since the beginning of the program , the PCNP relies on financing from the Electrical sector, Ocide, SEPI-Endesa, Westinghouse, General Electric, as well as from the industrial cooperators, Initec, UTE (Initec- Empresarios Agrupados), Ciemat, Enusa, Ensa and Tecnatom. The program is made up of the following projects, already concluded: - EPRI's Advanced Light Water Plants Certification Project - Westinghouse's AP600 Project - General Electric's SBWR Project (presently paralyzed) and ABWR project Currently, the following project are under development, at different degrees of advance: - EPP project (European Passive Plant) - EBWR project (European Advanced Boiling Water Reactor)

  16. AAP Updates Recommendations on Car Seats

    Science.gov (United States)

    ... Size Email Print Share AAP Updates Recommendations on Car Seats Page Content Article Body Children should ride ... of approved car safety seats. Healthy Children Radio: Car Seat Safety Dennis Durbin, MD, FAAP, lead author ...

  17. Rapid Update Cycle (RUC) [13 km

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Rapid Update Cycle (RUC) weather forecast model was developed by the National Centers for Environmental Prediction (NCEP). On May 1, 2012, the RUC was replaced...

  18. Model Updating Nonlinear System Identification Toolbox Project

    Data.gov (United States)

    National Aeronautics and Space Administration — ZONA Technology proposes to develop an enhanced model updating nonlinear system identification (MUNSID) methodology by adopting the flight data with state-of-the-art...

  19. Veterans and agent orange: update 2000

    National Research Council Canada - National Science Library

    Division of Health Promotion and Disease Prevention Staff; Institute of Medicine, Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides

    2001-01-01

    Veterans and Agent Orange: Update 2000 examines the state of the scientific evidence regarding associations between diseases and exposure to dioxin and other chemical compounds in herbicides used in Vietnam...

  20. Rapid Update Cycle (RUC) [20 km

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Rapid Update Cycle (RUC) weather forecast model was developed by the National Centers for Environmental Prediction (NCEP). On May 1, 2012, the RUC was replaced...

  1. NODA for EPA's Updated Ozone Transport Modeling

    Science.gov (United States)

    Find EPA's NODA for the Updated Ozone Transport Modeling Data for the 2008 Ozone National Ambient Air Quality Standard (NAAQS) along with the ExitExtension of Public Comment Period on CSAPR for the 2008 NAAQS.

  2. Earth Observing System Covariance Realism Updates

    Science.gov (United States)

    Ojeda Romero, Juan A.; Miguel, Fred

    2017-01-01

    This presentation will be given at the International Earth Science Constellation Mission Operations Working Group meetings June 13-15, 2017 to discuss the Earth Observing System Covariance Realism updates.

  3. Updating Road Networks by Local Renewal from GPS Trajectories

    Directory of Open Access Journals (Sweden)

    Tao Wu

    2016-09-01

    Full Text Available The long production cycle and huge cost of collecting road network data often leave the data lagging behind the latest real conditions. However, this situation is rapidly changing as the positioning techniques ubiquitously used in mobile devices are gradually being implemented in road network research and applications. Currently, the predominant approaches infer road networks from mobile location information (e.g., GPS trajectory data directly using various extracting algorithms, which leads to expensive consumption of computational resources in the case of large-scale areas. For this reason, we propose an alternative that renews road networks with a novel spiral strategy, including a hidden Markov model (HMM for detecting potential problems in existing road network data and a method to update the data, on the local scale, by generating new road segments from trajectory data. The proposed approach reduces computation costs on roads with completed or updated information by updating problem road segments in the minimum range of the road network. We evaluated the performance of our proposals using GPS traces collected from taxies and OpenStreetMap (OSM road networks covering urban areas of Wuhan City.

  4. Environmental regulatory update table, July 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-08-01

    This Environmental Regulatory Update Table (July 1991) provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  5. Environmental Regulatory Update Table, November 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-12-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  6. Environmental Regulatory Update Table, April 1989

    International Nuclear Information System (INIS)

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action

  7. Environmental Regulatory Update Table, December 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1992-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  8. Environmental regulatory update table, March 1989

    International Nuclear Information System (INIS)

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-04-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action

  9. Environmental regulatory update table, March 1989

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-04-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  10. Update of Part 61 impacts analysis methodology

    International Nuclear Information System (INIS)

    Oztunali, O.I.; Roles, G.W.

    1986-01-01

    The US Nuclear Regulatory Commission is expanding the impacts analysis methodology used during the development of the 10 CFR Part 61 rule to allow improved consideration of costs and impacts of disposal of waste that exceeds Class C concentrations. The project includes updating the computer codes that comprise the methodology, reviewing and updating data assumptions on waste streams and disposal technologies, and calculation of costs for small as well as large disposal facilities. This paper outlines work done to date on this project

  11. Update of Part 61 impacts analysis methodology

    International Nuclear Information System (INIS)

    Oztunali, O.I.; Roles, G.W.; US Nuclear Regulatory Commission, Washington, DC 20555)

    1985-01-01

    The US Nuclear Regulatory Commission is expanding the impacts analysis methodology used during the development of the 10 CFR Part 61 regulation to allow improved consideration of costs and impacts of disposal of waste that exceeds Class C concentrations. The project includes updating the computer codes that comprise the methodology, reviewing and updating data assumptions on waste streams and disposal technologies, and calculation of costs for small as well as large disposal facilities. This paper outlines work done to date on this project

  12. Environmental Regulatory Update Table, April 1989

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  13. Environmental Regulatory Update Table, August 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M., Hawkins, G.T.; Salk, M.S.

    1991-09-01

    This Environmental Regulatory Update Table (August 1991) provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  14. Environmental Regulatory Update Table, September 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-10-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  15. Environmental Regulatory Update Table, October 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  16. Applied physiology of female soccer: an update.

    Science.gov (United States)

    Datson, Naomi; Hulton, Andrew; Andersson, Helena; Lewis, Tracy; Weston, Matthew; Drust, Barry; Gregson, Warren

    2014-09-01

    The popularity and professionalism of female soccer has increased markedly in recent years, with elite players now employed on either a professional or semi-professional basis. The previous review of the physiological demands of female soccer was undertaken two decades ago when the sport was in its relative infancy. Increased research coupled with greater training and competition demands warrants an updated review to consider the effect on physical performance and injury patterns. The physical demands of match-play along with the influence of factors such as the standard of competition, playing position and fatigue have been explored. Total distance covered for elite female players is approximately 10 km, with 1.7 km completed at high speed (>15 kmh(-1)) [corrected].Elite players complete 28% more high-speed running and 24 % more sprinting than moderate-level players. Decrements in high-speed running distance have been reported between and within halves, which may indicate an inability to maintain high-intensity activity. Although the physical capacity of female players is the most thoroughly researched area, comparisons are difficult due to differing protocols. Elite players exhibit maximal oxygen uptake (VO2max) values of 49.4-57.6 mL·kg(-1)·min(-1), Yo Yo Intermittent Endurance test level 2 (YYIE2) scores of 1,774 ± 532 m [mean ± standard deviation (SD)] and 20 m sprint times of 3.17 ± 0.03 s (mean ± SD). Reasons for the increased prevalence of anterior cruciate ligament injuries in females (2-6 times greater than males) are discussed, with anatomical, biomechanical loading and neuromuscular activation differences being cited in the literature. This review presents an in-depth contemporary examination of the applied physiology of the female soccer player.

  17. Working Memory Updating as a Predictor of Academic Attainment

    Science.gov (United States)

    Lechuga, M. Teresa; Pelegrina, Santiago; Pelaez, Jose L.; Martin-Puga, M. Eva; Justicia, M. Jose

    2016-01-01

    There is growing evidence supporting the importance of executive functions, and specifically working memory updating (WMU), for children's academic achievement. This study aimed to assess the specific contribution of updating to the prediction of academic performance. Two updating tasks, which included different updating components, were…

  18. Dutch Venous Ulcer guideline update.

    Science.gov (United States)

    Maessen-Visch, M Birgitte; de Roos, Kees-Peter

    2014-05-01

    The revised guideline of 2013 is an update of the 2005 guideline "venous leg ulcer". In this special project four separate guidelines (venous leg ulcer, varicose veins, compression therapy and deep venous disorders) were revised and developed simultaneously. A meeting was held including representatives of any organisation involved in venous disease management including patient organizations and health insurance companies. Eighteen clinical questions where defined, and a new strategy was used to accelerate the process. This resulted in two new and two revised guidelines within one year. The guideline committee advises use of the C of the CEAP classification as well as the Venous Clinical Severity Score (VCSS) and a Quality of life (QoL) score in the assessment of clinical signs. These can provide insight into the burden of disease and the effects of treatment as experienced by the patient. A duplex ultrasound should be performed in every patient to establish the underlying aetiology and to evaluate the need for treatment (which is discussed in a separate guideline). The use of the TIME model for describing venous ulcers is recommended. There is no evidence for antiseptic or antibiotic wound care products except for a Cochrane review in which some evidence is presented for cadexomer iodine. Signs of infection are the main reason for the use of oral antibiotics. When the ulcer fails to heal the use of oral aspirin and pentoxifylline can be considered as an adjunct. For the individual patient, the following aspects should be considered: the appearance of the ulcer (amount of exudate) according to the TIME model, the influence of wound care products on moisturising the wound, frequency of changing compression bandages, pain and allergies. The cost of the dressings should also be considered. Education and training of patients t improves compliance with compression therapy but does not influence wound healing rates. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  19. Gambling in Spain: update on experience, research and policy.

    Science.gov (United States)

    Jiménez-Murcia, Susana; Fernández-Aranda, Fernando; Granero, Roser; Menchón, Jose Manuel

    2014-10-01

    To describe the current situation of gambling in Spain, sketching its history and discussing the regulations and legislation currently in force within the framework of the European Union (EU), and to review the epidemiology of gambling in Spain, the self-help groups and professional treatments available, and their potential effectiveness. A systematic computerized search was performed in three databases (EMBASE, PubMed and PsychINFO, including articles and chapters) and the reference lists from previous reviews to obtain some of the most relevant studies published up to now on the topic of pathologic gambling in Spain. Similar to other EU countries, Spain has a high prevalence of pathologic gambling, focused on specific culturally bounded types of gambling. Expenditure in online gaming has risen significantly in the last few years, prompting the Spanish government to draft new legislation to regulate gaming. The gaming industry is expected to be one of the fastest growing sectors in Spain in the coming years owing to the rise of new technologies and the development of online gaming. © 2013 Society for the Study of Addiction.

  20. Update to Permeable Pavement Research at the Edison ...

    Science.gov (United States)

    The EPA’s Urban Watershed Management Branch (UWMB) has been monitoring the permeable pavement demonstration site at the Edison Environmental Center, NJ since 2010. This site has three different types of permeable pavements including interlocking concrete permeable pavers, pervious concrete, and porous asphalt. The permeable pavements are limited to parking spaces while adjacent driving lanes are impermeable and drain to the permeable surfaces. The parking lot is instrumented for continuous monitoring with thermistors and water content reflectometers that measure moisture as infiltrate passes through the storage gallery beneath the permeable pavements into the underlying native soil. Each permeable surface of the parking lot has four lined sections that capture infiltrate in tanks for water quality analyses; these tanks are capable of holding volumes up to 4.1 m3, which represents up to 38 mm (1.5 in.) for direct rainfall on the porous pavement and runoff from adjacent driving lanes that drain into the permeable surface.Previous technical releases concerning the demonstration site focused on monitoring techniques, observed chloride and nutrient concentrations, surface hydrology, and infiltration and evaporation rates. This presentation summarizes these past findings and addresses current water quality efforts including pH, solids analysis, total organic carbon, and chemical oxygen demand. Stormwater runoff continues to be a major cause of water pollution in

  1. Bioelectrochemical systems using microalgae - A concise research update.

    Science.gov (United States)

    Saratale, Rijuta Ganesh; Kuppam, Chandrasekar; Mudhoo, Ackmez; Saratale, Ganesh Dattatraya; Periyasamy, Sivagurunathan; Zhen, Guangyin; Koók, László; Bakonyi, Péter; Nemestóthy, Nándor; Kumar, Gopalakrishnan

    2017-06-01

    Excess consumption of energy by humans is compounded by environmental pollution, the greenhouse effect and climate change impacts. Current developments in the use of algae for bioenergy production offer several advantages. Algal biomass is hence considered a new bio-material which holds the promise to fulfil the rising demand for energy. Microalgae are used in effluents treatment, bioenergy production, high value added products synthesis and CO 2 capture. This review summarizes the potential applications of algae in bioelectrochemically mediated oxidation reactions in fully biotic microbial fuel cells for power generation and removal of unwanted nutrients. In addition, this review highlights the recent developments directed towards developing different types of microalgae MFCs. The different process factors affecting the performance of microalgae MFC system and some technological bottlenecks are also addressed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Research Update: Phonon engineering of nanocrystalline silicon thermoelectrics

    Directory of Open Access Journals (Sweden)

    Junichiro Shiomi

    2016-10-01

    Full Text Available Nanocrystalline silicon thermoelectrics can be a solution to improve the cost-effectiveness of thermoelectric technology from both material and integration viewpoints. While their figure-of-merit is still developing, recent advances in theoretical/numerical calculations, property measurements, and structural synthesis/fabrication have opened up possibilities to develop the materials based on fundamental physics of phonon transport. Here, this is demonstrated by reviewing a series of works on nanocrystalline silicon materials using calculations of multiscale phonon transport, measurements of interfacial heat conduction, and synthesis from nanoparticles. Integration of these approaches allows us to engineer phonon transport to improve the thermoelectric performance by introducing local silicon-oxide structures.

  3. Building America Research Benchmark Definition: Updated December 2009

    Energy Technology Data Exchange (ETDEWEB)

    Hendron, R.; Engebrecht, C.

    2010-01-01

    The Benchmark represents typical construction at a fixed point in time so it can be used as the basis for Building America's multi-year energy savings goals without chasing a 'moving target.'

  4. Organic rice IPM research update in the United States

    Science.gov (United States)

    U.S. organic rice production has steadily increased over the past decade, with a majority of the acreage being grown in the southern region. Because of the warm and humid environments and the long growing season in the region, weed, disease and insect pests are among the primary factors limiting org...

  5. Research update: finishing lambs and meat goat kids on pasture

    Science.gov (United States)

    Traditional sheep (Ovis aries), hair sheep and meat goat (Capra hircus) industries are growing rapidly in the Appalachian Region to help produce meats for ethnic markets. This niche market offers an economic opportunity for owners of small farms. Control of gastrointestinal (GI) parasites in goats...

  6. Avian Disease and Oncology Laboratory (ADOL) research update

    Science.gov (United States)

    GENOMICS To meet the growing demands of consumers, the poultry industry will need to continue to improve methods of selection in breeding programs for production and associated traits. One possible solution is genome-wide marker-assisted selection (GWMAS). In brief, evenly-spaced genetic markers s...

  7. Research update: Avian Disease and Oncology Laboratory avian tumor viruses

    Science.gov (United States)

    Genomics and Immunogenetics Use of genomics to identify QTL, genes, and proteins associated with resistance to Marek’s disease. Marek’s disease (MD), a lymphoproliferative disease caused by the highly oncogenic herpesvirus Marek's disease virus (MDV), continues to be a major disease concern to the p...

  8. Research Update 2010: Outdoor Education Fatalities in Australia

    Science.gov (United States)

    Brookes, Andrew

    2011-01-01

    This paper is part of an on-going project to examine outdoor education related deaths in Australia since 1960. It records 17 incidents not previously recorded in papers in this series (Brookes, 2003a, 2003b, 2004, 2007), in which 15 participants, two supervisors or teachers, and one member of the public died. Eleven of the incidents occurred since…

  9. Research Update: Interfacing ultrasmall metal nanoclusters with biological systems

    Science.gov (United States)

    Shang, Li; Nienhaus, G. Ulrich

    2017-05-01

    Metal nanoclusters (NCs), a new type of nanomaterial with unique physicochemical properties, show great potential in many biomedical applications. Understanding their behavior in the complex biological environment is critical not only for designing highly efficient NC-based nanomedicines but also for elucidating the biological impact (e.g., toxicity) of these emerging nanomaterials. In this review, we give an overview of recent progress in exploring interactions of metal NCs with biological systems, including protein adsorption onto NCs, NC interactions with cells, and also the in vivo behavior of NCs. We also discuss the biological responses to the interactions, key parameters defining the interactions, and current challenges in the exploration of NCs in the complex biological environment.

  10. Updates on Nutraceutical Sleep Therapeutics and Investigational Research

    OpenAIRE

    Yurcheshen, Michael; Seehuus, Martin; Pigeon, Wilfred

    2015-01-01

    Approximately 50% of the population will suffer from a sleep disorder over the course of their lifetime. There is increasing interest in nutraceuticals for these conditions. The quality of the evidence for the safety and effectiveness of using these supplements to treat sleep disorders varies substantially. In this review, we discuss the data about the effectiveness and safety of six commonly used plant-based sleep therapeutics: caffeine, chamomile, cherries, kava kava, L-tryptophan, marij...

  11. Joint Actinide Shock Physics Experimental Research (JASPER) Facility Update

    International Nuclear Information System (INIS)

    Conrad, C. H.; Miller, J.; Cowan, M.; Martinez, M.; Whitcomb, B.

    2003-01-01

    The JASPER Facility utilizes a Two-Stage Light Gas Gun to conduct equation-of-state(EOS) experiments on plutonium and other special nuclear materials. The overall facility will be discussed with emphasis on the Two-Stage Light Gas Gun characteristics and control interfaces and containment. The containment systems that were developed for this project will be presented

  12. Updates on Nutraceutical Sleep Therapeutics and Investigational Research

    Directory of Open Access Journals (Sweden)

    Michael Yurcheshen

    2015-01-01

    Full Text Available Approximately 50% of the population will suffer from a sleep disorder over the course of their lifetime. There is increasing interest in nutraceuticals for these conditions. The quality of the evidence for the safety and effectiveness of using these supplements to treat sleep disorders varies substantially. In this review, we discuss the data about the effectiveness and safety of six commonly used plant-based sleep therapeutics: caffeine, chamomile, cherries, kava kava, L-tryptophan, marijuana, and valerian. We explore both historical uses of each substance and the current state of the literature.

  13. Research Update: Nanogenerators for self-powered autonomous wireless sensors

    Science.gov (United States)

    Khan, Usman; Hinchet, Ronan; Ryu, Hanjun; Kim, Sang-Woo

    2017-07-01

    Largely distributed networks of sensors based on the small electronics have great potential for health care, safety, and environmental monitoring. However, in order to have a maintenance free and sustainable operation, such wireless sensors have to be self-powered. Among various energies present in our environment, mechanical energy is widespread and can be harvested for powering the sensors. Piezoelectric and triboelectric nanogenerators (NGs) have been recently introduced for mechanical energy harvesting. Here we introduce the architecture and operational modes of self-powered autonomous wireless sensors. Thereafter, we review the piezoelectric and triboelectric NGs focusing on their working mechanism, structures, strategies, and materials.

  14. USA Space Debris Environment, Operations, and Research Updates

    Science.gov (United States)

    Liou, J.-C.

    2018-01-01

    Space Missions in 2017 Earth Satellite Population Collision Avoidance Maneuvers Post mission Disposal of U.S.A. Spacecraft Space Situational Awareness (SSA) and the Space Debris Sensor (SDS) A total of 86 space launches placed more than 400 spacecraft into Earth orbits during 2017, following the trend of increase over the past decade NASA has established conjunction assessment processes for its human spaceflight and uncrewed spacecraft to avoid accidental collisions with objects tracked by the U.S. Space Surveillance Network - NASA also assists other U.S. government spacecraft owners with conjunction assessments and subsequent maneuvers The ISS has conducted 25 debris collision avoidance maneuvers since 1999 - None in 2016-2017, but an ISS visiting vehicle had one collision avoidance maneuver in 2017 During 2017 NASA executed or assisted in the execution of 21 collision avoidance maneuvers by uncrewed spacecraft - Four maneuvers were conducted to avoid debris from Fengyun-1C - Two maneuvers were conducted to avoid debris from the collision of Cosmos 2251 and Iridium 33 - One maneuver was conducted to avoid the ISS NASA has established conjunction assessment processes for its human spaceflight and uncrewed spacecraft to avoid accidental collisions with objects tracked by the U.S. Space Surveillance Network - NASA also assists other U.S. government spacecraft owners with conjunction assessments and subsequent maneuvers The ISS has conducted 25 debris collision avoidance maneuvers since 1999 - None in 2016-2017, but an ISS visiting vehicle had one collision avoidance maneuver in 2017 During 2017 NASA executed or assisted in the execution of 21 collision avoidance maneuvers by uncrewed spacecraft - Four maneuvers were conducted to avoid debris from Fengyun-1C - Two maneuvers were conducted to avoid debris from the collision of Cosmos 2251 and Iridium 33 The 2014-15 NASA Engineering and Safety Center (NESC) study on the micrometeoroid and orbital debris (MMOD) assessment for the Joint Polar Satellite System (JPSS) provided the following findings - Millimeter-sized orbital debris pose the highest penetration risk to most operational spacecraft in LEO - The most effective means to collect direct measurement data on millimetersized debris above 600 km altitude is to conduct in situ measurements - There is currently no in situ data on such small debris above 600 km altitude Since the orbital debris population follows a power-law size distribution, there are many more millimeter-sized debris than the large tracked objects - Current conjunction assessments and collision avoidance maneuvers against the tracked objects (which are typically 10 cm and larger) only address a small fraction (Space Debris Sensor (SDS) - One maneuver was conducted to avoid the ISS

  15. Stress, alcohol and drug interaction: an update of human research

    OpenAIRE

    Uhart, Magdalena; Wand, Gary S.

    2008-01-01

    A challenging question that continues unanswered in the field of addiction is why some individuals are more vulnerable to substance use disorders than others. Numerous risk factors for alcohol and other drugs of abuse, including exposure to various forms of stress, have been identified in clinical studies. However, the neurobiological mechanisms that underlie this relationship remain unclear. Critical neurotransmitters, hormones and neurobiological sites have been recognized, which may provid...

  16. Stress, alcohol and drug interaction: an update of human research.

    Science.gov (United States)

    Uhart, Magdalena; Wand, Gary S

    2009-01-01

    A challenging question that continues unanswered in the field of addiction is why some individuals are more vulnerable to substance use disorders than others. Numerous risk factors for alcohol and other drugs of abuse, including exposure to various forms of stress, have been identified in clinical studies. However, the neurobiological mechanisms that underlie this relationship remain unclear. Critical neurotransmitters, hormones and neurobiological sites have been recognized, which may provide the substrates that convey individual differences in vulnerability to addiction. With the advent of more sophisticated measures of brain function in humans, such as functional imaging technology, the mechanisms and neural pathways involved in the interactions between drugs of abuse, the mesocorticolimbic dopamine system and stress systems are beginning to be characterized. This review provides a neuroadaptive perspective regarding the role of the hormonal and brain stress systems in drug addiction with a focus on the changes that occur during the transition from occasional drug use to drug dependence. We also review factors that contribute to different levels of hormonal/brain stress activation, which has implications for understanding individual vulnerability to drug dependence. Ultimately, these efforts may improve our chances of designing treatment strategies that target addiction at the core of the disorder.

  17. Transit research and industry news update : March 2010.

    Science.gov (United States)

    2010-03-01

    SPECIAL : Administrator Rogoff Issues Oral Statement on Federal Transit Administrations Recent Audit of WMATA and the Tri-State Oversight Committee .................................................. 3 : Subcommittee Hears Plans for Improving Trans...

  18. Quantifying Update Effects in Citizen-Oriented Software

    Directory of Open Access Journals (Sweden)

    Ion Ivan

    2009-02-01

    Full Text Available Defining citizen-oriented software. Detailing technical issues regarding update process in this kind of software. Presenting different effects triggered by types of update. Building model for update costs estimation, including producer-side and consumer-side effects. Analyzing model applicability on INVMAT – large scale matrix inversion software. Proposing a model for update effects estimation. Specifying ways for softening effects of inaccurate updates.

  19. Citation Discovery Tools for Conducting Adaptive Meta-analyses to Update Systematic Reviews.

    Science.gov (United States)

    Bae, Jong-Myon; Kim, Eun Hee

    2016-03-01

    The systematic review (SR) is a research methodology that aims to synthesize related evidence. Updating previously conducted SRs is necessary when new evidence has been produced, but no consensus has yet emerged on the appropriate update methodology. The authors have developed a new SR update method called 'adaptive meta-analysis' (AMA) using the 'cited by', 'similar articles', and 'related articles' citation discovery tools in the PubMed and Scopus databases. This study evaluates the usefulness of these citation discovery tools for updating SRs. Lists were constructed by applying the citation discovery tools in the two databases to the articles analyzed by a published SR. The degree of overlap between the lists and distribution of excluded results were evaluated. The articles ultimately selected for the SR update meta-analysis were found in the lists obtained from the 'cited by' and 'similar' tools in PubMed. Most of the selected articles appeared in both the 'cited by' lists in Scopus and PubMed. The Scopus 'related' tool did not identify the appropriate articles. The AMA, which involves using both citation discovery tools in PubMed, and optionally, the 'related' tool in Scopus, was found to be useful for updating an SR.

  20. Partial updating of clinical practice guidelines often makes more sense than full updating: a systematic review on methods and the development of an updating procedure.

    Science.gov (United States)

    Becker, Monika; Neugebauer, Edmund A M; Eikermann, Michaela

    2014-01-01

    To conduct a systematic review of the methods used to determine when and how to update clinical practice guidelines (CPGs) and develop a procedure for updating CPGs. We searched MEDLINE, Embase, and the Cochrane Methodology Register for methodological publications on updating CPGs. Guideline development manuals were obtained from the Web sites of guideline-developing organizations. Using the information obtained from these records, a procedure for updating CPGs was developed. A total of 5,116 journal articles were screened, and seven articles met the criteria for inclusion. Forty-seven manuals were included; of these, eight included details about the methods used to update the guidelines. Most of the included publications focused on assessing whether the CPGs needed updating and not on how to update them. The developed procedure includes a systematic monitoring system and a scheduled process for updating the CPGs, which includes guidance on how to determine the type and scope of an update. Partial updating often makes more sense than updating the whole CPG because topics and recommendations differ in terms of the need for updating. Guideline developers should implement a systematic updating procedure that includes an ongoing monitoring system that is appropriate for the nature of the guideline topics and the capabilities of the developers. Copyright © 2014 Elsevier Inc. All rights reserved.