WorldWideScience

Sample records for research turbine cart

  1. Real-Time Digital Simulation of Inertial Response with Hardware-in-the-Loop Implementation on the CART3 Wind Turbine at the National Wind Technology Center

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Wenzhong; Wang, Xiao; Muljadi, Eduard; Gevorgian, Vahan; Scholbrock, Andrew

    2017-09-01

    the performances of the two methods in terms of their frequency nadirs, rates of change of frequency, and recovery times. We conclude the results under various wind speeds and penetration cases, which provide insight into designing the inertial response of WTGs. Further, we discuss the impact of the parameters on the performance of the inertial control methods. We evaluate both the scaling factors for the FBIC method and the slope values for the TLIC methods. The simulation work shows the characteristics of different inertial responses compared to conventional synchronous generators. Based on the simulation results, we modify, improve, and test the inertial control methods under a more realistic wind turbine model based on FAST. We then validate the inertial responses under highly turbulent wind conditions generated by TurbSim, and we examine their influences on the turbine mechanical components. The extensive simulation proves the effectiveness of the proposed inertial control methods as well as the nine-bus test power system. We then reconsider the parameters. We rebuild the same test power system using Real time Simulator Computer Aided Design (RSCAD), and we implement the inertial control methods in the real Controls Advanced Research Turbine (CART3), which is prepared for the hardware-in-the-loop field-test simulation. After the setups for the hardware and software hybrid simulation platform are complete, the inertial response is further tested on a real wind turbine for the first time, in which CART3 release the controlled inertial response against the emulated frequency excursion, provided by the real-time simulated power system test bed in RTDS.

  2. ADVANCED GAS TURBINE SYSTEMS RESEARCH

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2002-04-01

    The activities of the Advanced Gas Turbine Systems Research (AGTSR) program for this reporting period are described in this quarterly report. The report is divided into discussions of Membership, Administration, Technology Transfer (Workshop/Education), Research and Miscellaneous Related Activity. Items worthy of note are presented in extended bullet format following the appropriate heading.

  3. ADVANCED GAS TURBINE SYSTEMS RESEARCH

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2002-02-01

    The activities of the Advanced Gas Turbine Systems Research (AGTSR) program for this reporting period are described in this quarterly report. The report is divided into discussions of Membership, Administration, Technology Transfer (Workshop/Education), Research and Miscellaneous Related Activity. Items worthy of note are presented in extended bullet format following the appropriate heading.

  4. Small Wind Research Turbine: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Corbus, D.; Meadors, M.

    2005-10-01

    The Small Wind Research Turbine (SWRT) project was initiated to provide reliable test data for model validation of furling wind turbines and to help understand small wind turbine loads. This report will familiarize the user with the scope of the SWRT test and support the use of these data. In addition to describing all the testing details and results, the report presents an analysis of the test data and compares the SWRT test data to simulation results from the FAST aeroelastic simulation model.

  5. Cancer Immunotherapy Using CAR-T Cells: From the Research Bench to the Assembly Line.

    Science.gov (United States)

    Gomes-Silva, Diogo; Ramos, Carlos A

    2018-02-01

    The focus of cancer treatment has recently shifted toward targeted therapies, including immunotherapy, which allow better individualization of care and are hoped to increase the probability of success for patients. Specifically, T cells genetically modified to express chimeric antigen receptors (CARs; CAR-T cells) have generated exciting results. Recent clinical successes with this cutting-edge therapy have helped to push CAR-T cells toward approval for wider use. However, several limitations need to be addressed before the widespread use of CAR-T cells as a standard treatment. Here, a succinct background on adoptive T-cell therapy (ATCT)is given. A brief overview of the structure of CARs, how they are introduced into T cells, and how CAR-T cell expansion and selection is achieved in vitro is then presented. Some of the challenges in CAR design are discussed, as well as the difficulties that arise in large-scale CAR-T cell manufacture that will need to be addressed to achieve successful commercialization of this type of cell therapy. Finally, developments already on the horizon are discussed. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Research status and trend of wind turbine aerodynamic noise?

    Institute of Scientific and Technical Information of China (English)

    Xiaodong LI; Baohong BAI; Yingbo XU; Min JIANG

    2016-01-01

    The main components of the wind turbine aerodynamic noise are introduced. A detailed review is given on the theoretical prediction, experimental measurement, and numerical simulation methods of wind turbine noise, with speci?c attention to appli-cations. Furthermore, suppression techniques of wind turbine aerodynamic noise are discussed. The perspective of future research on the wind turbine aerodynamic noise is presented.

  7. Turbine Seal Research at NASA GRC

    Science.gov (United States)

    Proctor, Margaret P.; Steinetz, Bruce M.; Delgado, Irebert R.; Hendricks, Robert C.

    2011-01-01

    Low-leakage, long-life turbomachinery seals are important to both Space and Aeronautics Missions. (1) Increased payload capability (2) Decreased specific fuel consumption and emissions (3) Decreased direct operating costs. NASA GRC has a history of significant accomplishments and collaboration with industry and academia in seals research. NASA's unique, state-of-the-art High Temperature, High Speed Turbine Seal Test Facility is an asset to the U.S. Engine / Seal Community. Current focus is on developing experimentally validated compliant, non-contacting, high temperature seal designs, analysis, and design methodologies to enable commercialization.

  8. Research in Aeroelasticity EFP-2006[Wind turbines

    Energy Technology Data Exchange (ETDEWEB)

    Bak, C.

    2007-07-15

    This report contains the results from the Energy Research Project 'Program for Research in Applied Aeroelasticity, EFP-2006' covering the period from 1. April 2006 to 31. March 2007. A summary of the main results from the project is given in the following. The aerodynamics for rotors incl. spinner and winglets were clarified and the needed premises for an optimal rotor were explained. Also, the influence of viscous effects on rotor blades was investigated and the results indicated a range of optimum tip speed ratios. The use of winglets for wind turbine rotor was investigated and it was found that they can be used successfully, but that downwind and short winglets are most efficient. Investigating a strategy for reduction of loads and vibrations at extreme wind speeds showed that there are considerably uncertainties in the numerical models and that the main concluding remark is that measurements on a real blade or a real turbine are needed to further conclude the investigation. In the study of flutter and other torsional vibrations of blades at large deflections, modeling and analysis of the dynamics of a hydraulic pitch system for a 5 MW wind turbine was carried out. It was shown that the compressibility of the hydraulic oil introduced a dynamic mode in the pitch bearing degree of freedom. Also, investigating flutter for blades at large deflections showed that the flutter limit for a 5MW blade was moved significantly compared to blades without large deflections. The influence of modeling nacelle components was investigated by developing a generalized method to interface dynamic systems to the aeroelastic program HAWC2 and by exemplify by modeling the nacelle of an aeroelastic wind turbine model in a more detailed way by including a single planet stage of a gearbox. This simplified gearbox model captures in essence the splitting of the driving torque from the rotor shaft to the frame of the nacelle and to the generator. Investigating the influence of wind

  9. Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research.

    Science.gov (United States)

    Inoo, Kanako; Inagaki, Ryo; Fujiwara, Kento; Sasawatari, Shigemi; Kamigaki, Takashi; Nakagawa, Shinsaku; Okada, Naoki

    2016-01-01

    We previously reported that tumor vessel-redirected T cells, which were genetically engineered with chimeric antigen receptor (CAR) specific for vascular endothelial growth factor receptor 2 (VEGFR2), demonstrated significant antitumor effects in various murine solid tumor models. In the present study, we prepared anti-VEGFR2 CAR-T cells by CAR-coding mRNA electroporation (mRNA-EP) and analyzed their immunological characteristics and functions for use in clinical research. The expression of anti-VEGFR2 CAR on murine and human T cells was detected with approximately 100% efficiency for a few days, after peaking 6-12 hours after mRNA-EP. Triple transfer of murine anti-VEGFR2 CAR-T cells into B16BL6 tumor-bearing mice demonstrated an antitumor effect comparable to that for the single transfer of CAR-T cells engineered with retroviral vector. The mRNA-EP did not cause any damage or defects to human T-cell characteristics, as determined by viability, growth, and phenotypic parameters. Additionally, two kinds of human anti-VEGFR2 CAR-T cells, which expressed different CAR construction, differentiated to effector phase with cytokine secretion and cytotoxic activity in antigen-specific manner. These results indicate that our anti-VEGFR2 CAR-T cells prepared by mRNA-EP have the potential in terms of quality and performance to offer the prospect of safety and efficacy in clinical research as cellular medicine.

  10. Research in aeroelasticity[Wind turbines

    Energy Technology Data Exchange (ETDEWEB)

    Bak, C.

    2006-05-15

    In the Energy Research Project 'Program for Research in Applied Aeroelasticity' (EFP2005), Risoe National Laboratory (Risoe) and the Technical University of Denmark (DTU) have applied and further developed the tools in the aeroelastic design complex. The main results from the project are: 1) Adding a winglet to a wind turbine blade for minimizing the induced drag of the blade led to the biggest increase in power of 1.4%. 2) Transient wind loads during pitch motion are determined using CFD. Compared to the NREL/NASA Ames test, reasonably good agreement is seen. 3) A general method was developed for the determination of 3D angle of attack for rotating blades from either measurements or numerical computations using CFD. 4) A model of the far wake behind wind turbines was developed for stability studies of the tip vortices in the far wake. 5) Investigating the blade root region showed that the power efficiency, CP, locally can be increased significantly beyond the Betz limit, but that the global CP for the rotor cannot exceed the Betz limit. When including tip losses and a minimum blade drag coefficient, a maximum rotor CP in the range of 0.51-0.52 was obtained. 6) A new airfoil family was designed and a 3D airfoil design tool was developed. Compared to the Risoe-B1 family, the new airfoil family showed similar or improved aerodynamic and structural characteristics. 7) Four different airfoils were analyzed to reveal the differences between 2D and 3D CFD. The major conclusions are the dependency of computational results to transition modelling, and the ability of 3D DES calculations to realistically simulate the turbulent wake of an airfoil in stall. 8) The capability of a theory for simulation of Gaussian turbulence driven gust events was demonstrated by emulating a violent shear gust event from a complex site. An asymptotic model for the PDF of the largest excursion from the mean level, during an arbitrary recurrence period, has been derived for a stochastic

  11. Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research

    Directory of Open Access Journals (Sweden)

    Kanako Inoo

    2016-01-01

    Full Text Available We previously reported that tumor vessel-redirected T cells, which were genetically engineered with chimeric antigen receptor (CAR specific for vascular endothelial growth factor receptor 2 (VEGFR2, demonstrated significant antitumor effects in various murine solid tumor models. In the present study, we prepared anti-VEGFR2 CAR-T cells by CAR-coding mRNA electroporation (mRNA-EP and analyzed their immunological characteristics and functions for use in clinical research. The expression of anti-VEGFR2 CAR on murine and human T cells was detected with approximately 100% efficiency for a few days, after peaking 6–12 hours after mRNA-EP. Triple transfer of murine anti-VEGFR2 CAR-T cells into B16BL6 tumor-bearing mice demonstrated an antitumor effect comparable to that for the single transfer of CAR-T cells engineered with retroviral vector. The mRNA-EP did not cause any damage or defects to human T-cell characteristics, as determined by viability, growth, and phenotypic parameters. Additionally, two kinds of human anti-VEGFR2 CAR-T cells, which expressed different CAR construction, differentiated to effector phase with cytokine secretion and cytotoxic activity in antigen-specific manner. These results indicate that our anti-VEGFR2 CAR-T cells prepared by mRNA-EP have the potential in terms of quality and performance to offer the prospect of safety and efficacy in clinical research as cellular medicine.

  12. Research and development of ceramic gas turbine

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Kazuo [National Aerospace Laboratory, Chofu-shi, Tokyo (Japan)

    1993-12-31

    The CO{sub 2} caused by the consumption of hydrocarbon fuel is one of the main gases which affect the global climate. In order to reduce the formation of CO{sub 2}, it is necessary to conserve energy as effectively as possible. Therefore the heat energy provided by the fuel should be utilized in multi-cascades. The energy at the high temperature should be used for the generation of electric power and the energy at low temperature could be used for making the steam and the hot water. The gas turbine is preferable for this purpose. The heat energy of exhaust gas can be reused more easily. The two systems are proposed by using the gas turbine as the high temperature stage. One is the cogeneration system and the other is the combined cycle. The former generates electric power by the gas turbine and make steam or hot water in the exhaust gas. The latter employs the gas turbine as the high temperature cycle and the steam turbine as the low temperature cycle.

  13. UNIVERSITY TURBINE SYSTEMS RESEARCH PROGRAM SUMMARY AND DIRECTORY

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence P. Golan; Richard A. Wenglarz

    2004-07-01

    The South Carolina Institute for Energy Studies (SCIES), administratively housed at Clemson University, has participated in the advancement of combustion turbine technology for over a decade. The University Turbine Systems Research Program, previously referred to as the Advanced Gas Turbine Systems Research (AGTSR) program, has been administered by SCIES for the U.S. DOE during the 1992-2003 timeframe. The structure of the program is based on a concept presented to the DOE by Clemson University. Under the supervision of the DOE National Energy Technology Laboratory (NETL), the UTSR consortium brings together the engineering departments at leading U.S. universities and U.S. combustion turbine developers to provide a solid base of knowledge for the future generations of land-based gas turbines. In the UTSR program, an Industrial Review Board (IRB) (Appendix C) of gas turbine companies and related organizations defines needed gas turbine research. SCIES prepares yearly requests for university proposals to address the research needs identified by the IRB organizations. IRB technical representatives evaluate the university proposals and review progress reports from the awarded university projects. To accelerate technology transfer technical workshops are held to provide opportunities for university, industry and government officials to share comments and improve quality and relevancy of the research. To provide educational growth at the Universities, in addition to sponsored research, the UTSR provides faculty and student fellowships. The basis for all activities--research, technology transfer, and education--is the DOE Turbine Program Plan and identification, through UTSR consortium group processes, technology needed to meet Program Goals that can be appropriately researched at Performing Member Universities.

  14. Wagging the Dog, Carting the Horse: Testing and Improving Schools. Summary of Conference Proceedings. Research into Practice Project.

    Science.gov (United States)

    Herman, Joan; And Others

    The purpose of the conference, "Wagging the Dog, Carting the Horse: Testing vs. Improving California Schools," was to discuss alternative perspectives on testing and evaluation in education and their role in improving teaching and learning. Four papers were presented: (1) "Using Educational Evaluation for the Improvement of California Schools," by…

  15. Service Cart For Engines

    Science.gov (United States)

    Ng, Gim Shek

    1995-01-01

    Cart supports rear-mounted air-cooled engine from Volkswagen or Porsche automobile. One person removes, repairs, tests, and reinstalls engine of car, van, or home-built airplane. Consists of framework of wood, steel, and aluminum components supported by four wheels. Engine lifted from vehicle by hydraulic jack and gently lowered onto waiting cart. Jack removed from under engine. Rear of vehicle raised just enough that engine can be rolled out from under it. Cart easily supports 200-lb engine. Also used to hold transmission. With removable sheet-metal top, cart used as portable seat.

  16. Assessment of research needs for wind turbine rotor materials technology

    National Research Council Canada - National Science Library

    National Research Council Staff; Commission on Engineering and Technical Systems; Division on Engineering and Physical Sciences; National Research Council; National Academy of Sciences

    1991-01-01

    ... on Assessment of Research Needs for Wind Turbine Rotor Materials Technology Energy Engineering Board Commission on Engineering and Technical Systems National Research Council NATIONAL ACADEMY PRESS Washington, D.C. 1991 Copyrightthe true use are Please breaks Page inserted. accidentally typesetting been have may original the from errors not...

  17. Aircraft Turbine Engine Control Research at NASA Glenn Research Center

    Science.gov (United States)

    Garg, Sanjay

    2014-01-01

    This lecture will provide an overview of the aircraft turbine engine control research at NASA (National Aeronautics and Space Administration) Glenn Research Center (GRC). A brief introduction to the engine control problem is first provided with a description of the current state-of-the-art control law structure. A historical aspect of engine control development since the 1940s is then provided with a special emphasis on the contributions of GRC. The traditional engine control problem has been to provide a means to safely transition the engine from one steady-state operating point to another based on the pilot throttle inputs. With the increased emphasis on aircraft safety, enhanced performance and affordability, and the need to reduce the environmental impact of aircraft, there are many new challenges being faced by the designers of aircraft propulsion systems. The Controls and Dynamics Branch (CDB) at GRC is leading and participating in various projects in partnership with other organizations within GRC and across NASA, other government agencies, the U.S. aerospace industry, and academia to develop advanced propulsion controls and diagnostics technologies that will help meet the challenging goals of NASA programs under the Aeronautics Research Mission. The second part of the lecture provides an overview of the various CDB technology development activities in aircraft engine control and diagnostics, both current and some accomplished in the recent past. The motivation for each of the research efforts, the research approach, technical challenges and the key progress to date are summarized. The technologies to be discussed include system level engine control concepts, gas path diagnostics, active component control, and distributed engine control architecture. The lecture will end with a futuristic perspective of how the various current technology developments will lead to an Intelligent and Autonomous Propulsion System requiring none to very minimum pilot interface

  18. Research Strategy for Modeling the Complexities of Turbine Heat Transfer

    Science.gov (United States)

    Simoneau, Robert J.

    1996-01-01

    The subject of this paper is a NASA research program, known as the Coolant Flow Management Program, which focuses on the interaction between the internal coolant channel and the external film cooling of a turbine blade and/or vane in an aircraft gas turbine engine. The turbine gas path is really a very complex flow field. The combination of strong pressure gradients, abrupt geometry changes and intersecting surfaces, viscous forces, rotation, and unsteady blade/vane interactions all combine to offer a formidable challenge. To this, in the high pressure turbine, we add the necessity of film cooling. The ultimate goal of the turbine designer is to maintain or increase the high level of turbine performance and at the same time reduce the amount of coolant flow needed to achieve this end. Simply stated, coolant flow is a penalty on the cycle and reduces engine thermal efficiency. Accordingly, understanding the flow field and heat transfer associated with the coolant flow is a priority goal. It is important to understand both the film cooling and the internal coolant flow, particularly their interaction. Thus, the motivation for the Coolant Flow Management Program. The paper will begin with a brief discussion of the management and research strategy, will then proceed to discuss the current attack from the internal coolant side, and will conclude by looking at the film cooling effort - at all times keeping sight of the primary goal the interaction between the two. One of the themes of this paper is that complex heat transfer problems of this nature cannot be attacked by single researchers or even groups of researchers, each working alone. It truly needs the combined efforts of a well-coordinated team to make an impact. It is important to note that this is a government/industry/university team effort.

  19. State of the cart.

    Science.gov (United States)

    Bernstein, C; Weiss, S; Lorenzini, B

    1994-03-15

    Food on wheels: it's here, there and everywhere. But while some operations rev up cart expansion plans, others have shifted into low gear. Here's an update on that '90s phenomenon: mobile merchandising.

  20. Overview of Variable-Speed Power-Turbine Research

    Science.gov (United States)

    Welch, Gerard E.

    2011-01-01

    The vertical take-off and landing (VTOL) and high-speed cruise capability of the NASA Large Civil Tilt-Rotor (LCTR) notional vehicle is envisaged to enable increased throughput in the national airspace. A key challenge of the LCTR is the requirement to vary the main rotor speeds from 100% at take-off to near 50% at cruise as required to minimize mission fuel burn. The variable-speed power-turbine (VSPT), driving a fixed gear-ratio transmission, provides one approach for effecting this wide speed variation. The key aerodynamic and rotordynamic challenges of the VSPT were described in the FAP Conference presentation. The challenges include maintaining high turbine efficiency at high work factor, wide (60 deg.) of incidence variation in all blade rows due to the speed variation, and operation at low Reynolds numbers (with transitional flow). The PT -shaft of the VSPT must be designed for safe operation in the wide speed range required, and therefore poses challenges associated with rotordynamics. The technical challenges drive research activities underway at NASA. An overview of the NASA SRW VSPT research activities was provided. These activities included conceptual and preliminary aero and mechanical (rotordynamics) design of the VSPT for the LCTR application, experimental and computational research supporting the development of incidence tolerant blading, and steps toward component-level testing of a variable-speed power-turbine of relevance to the LCTR application.

  1. NWTC Researchers Field-Test Advanced Control Turbine Systems to Increase Performance, Decrease Structural Loading of Wind Turbines and Plants

    Energy Technology Data Exchange (ETDEWEB)

    2015-08-01

    Researchers at the National Renewable Energy Laboratory's (NREL's) National Wind Technology Center (NWTC) are studying component controls, including new advanced actuators and sensors, for both conventional turbines as well as wind plants. This research will help develop innovative control strategies that reduce aerodynamic structural loads and improve performance. Structural loads can cause damage that increase maintenance costs and shorten the life of a turbine or wind plant.

  2. UNIVERSITY TURBINE SYSTEMS RESEARCH-HIGH EFFICIENCY ENGINES AND TURBINES (UTSR-HEET)

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence P. Golan; Richard A. Wenglarz; William H. Day

    2003-03-01

    In 2002, the U S Department of Energy established a cooperative agreement for a program now designated as the University Turbine Systems (UTSR) Program. As stated in the cooperative agreement, the objective of the program is to support and facilitate development of advanced energy systems incorporating turbines through a university research environment. This document is the first annual, technical progress report for the UTSR Program. The Executive Summary describes activities for the year of the South Carolina Institute for Energy Studies (SCIES), which administers the UTSR Program. Included are descriptions of: Outline of program administrative activities; Award of the first 10 university research projects resulting from a year 2001 RFP; Year 2002 solicitation and proposal selection for awards in 2003; Three UTSR Workshops in Combustion, Aero/Heat Transfer, and Materials; SCIES participation in workshops and meetings to provide input on technical direction for the DOE HEET Program; Eight Industrial Internships awarded to higher level university students; Increased membership of Performing Member Universities to 105 institutions in 40 states; Summary of outreach activities; and a Summary table describing the ten newly awarded UTSR research projects. Attachment A gives more detail on SCIES activities by providing the monthly exceptions reports sent to the DOE during the year. Attachment B provides additional information on outreach activities for 2002. The remainder of this report describes in detail the technical approach, results, and conclusions to date for the UTSR university projects.

  3. 2002–2012: 10 Years of Research Progress in Horizontal-Axis Marine Current Turbines

    Directory of Open Access Journals (Sweden)

    Kai-Wern Ng

    2013-03-01

    Full Text Available Research in marine current energy, including tidal and ocean currents, has undergone significant growth in the past decade. The horizontal-axis marine current turbine is one of the machines used to harness marine current energy, which appears to be the most technologically and economically viable one at this stage. A number of large-scale marine current turbines rated at more than 1 MW have been deployed around the World. Parallel to the development of industry, academic research on horizontal-axis marine current turbines has also shown positive growth. This paper reviews previous research on horizontal-axis marine current turbines and provides a concise overview for future researchers who might be interested in horizontal-axis marine current turbines. The review covers several main aspects, such as: energy assessment, turbine design, wakes, generators, novel modifications and environmental impact. Future trends for research on horizontal-axis marine current turbines are also discussed.

  4. Jeux de cartes

    Directory of Open Access Journals (Sweden)

    Priscilla DE ROO

    1988-03-01

    Full Text Available Le dessinateur Cabu illustre par la carte deux étapes récentes de l'État de la France: les rapports entre eux (État et institutions et nous (les Français et leur territoire avant et après la cohabitation.

  5. Jeux de cartes

    Directory of Open Access Journals (Sweden)

    Pierre GENTELLE

    1986-09-01

    Full Text Available Dans la grande tradition de la science-fiction et des lieux imaginaires traduits ici en «jeux» de cartes, l'auteur bouleverse quelques localisations au prix de mouvements tectoniques imprévus et en prévoit quelques conséquences.

  6. Theoretical and Experimental Research Performed on the Tesla Turbine - Part I

    Directory of Open Access Journals (Sweden)

    Dorian Nedelcu

    2015-09-01

    Full Text Available The paper presents the theoretical and experimental research performed on a Tesla turbine driven by compressed air and designed to equip a teaching laboratory [1], [2]. It introduces the operating principle of the Tesla turbine, which was invented by engineer Nikola Tesla, a turbine which uses discs instead of blades, mounted on a shaft at a small distance between them. The turbine geometry, results from stress and flow calculations performed on the turbine rotor and assembly, using the Simulation modules and SolidWorks Flow Simulation program are presented. After designing the turbine, it becomes the subject of experimental research to determine the curve of the speed depending on the pressure. Also, the experimental research focuses on the behaviour of the turbine from a dynamic point of view [3].

  7. Research status on aero-acoustic noise from wind turbine blades

    International Nuclear Information System (INIS)

    Yang, B

    2013-01-01

    This paper describes the noise mechanisms and categories of modern large wind turbine and main noise sources. Then the latest progresses in wind turbine noise researches are described from three aspects: noise prediction model, detection of noise sources by microphone array technique and methods for noise reduction. Although the turbine is restricted to horizontal axis wind turbines, the noise prediction model and reduction methods also can be applied to other turbines when the noise mechanisms are similar. Microphone array technique can be applied to locate any kind of noise sources

  8. CART in the Regulation of Appetite and Energy Homeostasis

    Directory of Open Access Journals (Sweden)

    Jackie eLau

    2014-10-01

    Full Text Available The cocaine- and amphetamine-regulated transcript (CART has been the subject of significant interest for over a decade. Work to decipher the detailed mechanism of CART function has been hampered by the lack of specific pharmacological tools like antagonists and the absence of a specific CART receptor(s. However, extensive research has been devoted to elucidate the role of the CART peptide and it is now evident that CART is a key neurotransmitter and hormone involved in the regulation of diverse biological processes, including food intake, maintenance of body weight, reward and addiction, stress response, psychostimulant effects and endocrine functions1,2. In this review, we focus on knowledge gained on CART’s role in controlling appetite and energy homeostasis, and also address certain species differences between rodents and humans.

  9. Research on simulation of supercritical steam turbine system in large thermal power station

    Science.gov (United States)

    Zhou, Qiongyang

    2018-04-01

    In order to improve the stability and safety of supercritical steam turbine system operation in large thermal power station, the body of the steam turbine is modeled in this paper. And in accordance with the hierarchical modeling idea, the steam turbine body model, condensing system model, deaeration system model and regenerative system model are combined to build a simulation model of steam turbine system according to the connection relationship of each subsystem of steam turbine. Finally, the correctness of the model is verified by design and operation data of the 600MW supercritical unit. The results show that the maximum simulation error of the model is 2.15%, which meets the requirements of the engineering. This research provides a platform for the research on the variable operating conditions of the turbine system, and lays a foundation for the construction of the whole plant model of the thermal power plant.

  10. Controlling errors in unidosis carts

    Directory of Open Access Journals (Sweden)

    Inmaculada Díaz Fernández

    2010-01-01

    Full Text Available Objective: To identify errors in the unidosis system carts. Method: For two months, the Pharmacy Service controlled medication either returned or missing from the unidosis carts both in the pharmacy and in the wards. Results: Uncorrected unidosis carts show a 0.9% of medication errors (264 versus 0.6% (154 which appeared in unidosis carts previously revised. In carts not revised, the error is 70.83% and mainly caused when setting up unidosis carts. The rest are due to a lack of stock or unavailability (21.6%, errors in the transcription of medical orders (6.81% or that the boxes had not been emptied previously (0.76%. The errors found in the units correspond to errors in the transcription of the treatment (3.46%, non-receipt of the unidosis copy (23.14%, the patient did not take the medication (14.36%or was discharged without medication (12.77%, was not provided by nurses (14.09%, was withdrawn from the stocks of the unit (14.62%, and errors of the pharmacy service (17.56% . Conclusions: It is concluded the need to redress unidosis carts and a computerized prescription system to avoid errors in transcription.Discussion: A high percentage of medication errors is caused by human error. If unidosis carts are overlooked before sent to hospitalization units, the error diminishes to 0.3%.

  11. Fan Cart: The Next Generation

    Science.gov (United States)

    Lamore, Brian

    2016-01-01

    For years the fan cart has provided physics students with an excellent resource for exploring fundamental mechanics concepts such as acceleration, Newton's laws, impulse, momentum, work-energy, and energy conversions. "The Physics Teacher" has even seen some excellent do-it-yourself (DIY) fan carts and activities. If you are interested…

  12. Research on the nonintrusive measurement of the turbine blade vibration

    Science.gov (United States)

    Zhang, Shi hai; Li, Lu-ping; Rao, Hong-de

    2008-11-01

    It's one of the important ways to monitor the change of dynamic characteristic of turbine blades for ensuring safety operation of turbine unit. Traditional measurement systems for monitoring blade vibration generally use strain gauges attached to the surface of turbine blades, each strain gauge gives out an analogue signal related to blade deformation, it's maximal defect is only a few blades could be monitored which are attached by strain gauge. But the noncontact vibration measurement will be discussed would solve this problem. This paper deals with noncontact vibration measurement on the rotor blades of turbine through experiments. In this paper, the noncontact vibration measurement - Tip Timing Measurement will be presented, and will be improved. The statistics and DFT will be used in the improved measurement. The main advantage of the improved measurement is that only two sensors over the top of blades and one synchronous sensor of the rotor are used to get the exact vibration characteristics of the each blade in a row. In our experiment, we adopt NI Company's DAQ equipment: SCXI1001 and PCI 6221, three optical sensors, base on the graphics program soft LabVIEW to develop the turbine blade monitor system. At the different rotational speed of the rotor (1000r/m and 1200r/m) we do several experiments on the bench of the Turbine characteristic. Its results indicated that the vibration of turbine blade could be real-time monitored and accurately measured by the improved Tip Timing Measurement.

  13. A la Carte Community

    DEFF Research Database (Denmark)

    Gundelach, Peter; Brincker, Benedikte

    2010-01-01

    and shows that there are high levels of virtual as well as face-to-face interaction among the members. The participants feel that they belong to the community and many also feel that they are recognised as part of the community. However, the members do not share common values neither in relation to software......The exchange of open source software is a phenomenon that is becoming in- creasingly significant to IT users. This article presents the results of a study of the TYPO3 community, a community related to an open source CMS software. The article explores the community, identity and values of TYPO3...... pro- duction nor generally. Instead, they stress that you are free to choose your own values. Against this background, the authors introduce the notion of an ‘a la carte community', i.e. a community where individuals pick and choose their degree of participation and integra- tion into the community...

  14. FMIT alignment cart

    International Nuclear Information System (INIS)

    Potter, R.C.; Dauelsberg, L.B.; Clark, D.C.; Grieggs, R.J.

    1981-01-01

    The Fusion Materials Irradiation Test (FMIT) Facility alignment cart must perform several functions. It must serve as a fixture to receive the drift-tube girder assembly when it is removed from the linac tank. It must transport the girder assembly from the linac vault to the area where alignment or disassembly is to take place. It must serve as a disassembly fixture to hold the girder while individual drift tubes are removed for repair. It must align the drift tube bores in a straight line parallel to the girder, using an optical system. These functions must be performed without violating any clearances found within the building. The bore tubes of the drift tubes will be irradiated, and shielding will be included in the system for easier maintenance

  15. La redistribution des cartes.

    Directory of Open Access Journals (Sweden)

    Muriel Berthou Crestey

    2009-11-01

    Full Text Available Redessinée par Jacques Rancière, la carte du sensible acquiert une dimension interactive, formant un réseau de connexions organisé sans hiérarchie préétablie. Fondée sur le principe de l’horizontalité et de l’égalité, elle déplace les limites pour offrir un terrain propice à l’émancipation, permettant un cadrage inédit, un regard neuf. Chaque place assignée est désormais ouverte et vacante. Il n’y a plus de chemin tracé. Toute nouvelle configuration est possible et ...

  16. Research of performance prediction to energy on hydraulic turbine

    International Nuclear Information System (INIS)

    Quan, H; Li, R N; Li, Q F; Han, W; Su, Q M

    2012-01-01

    Refer to the low specific speed Francis turbine blade design principle and double-suction pump structure. Then, design a horizontal double-channel hydraulic turbine Francis. Through adding different guide vane airfoil and and no guide vane airfoil on the hydraulic conductivity components to predict hydraulic turbine energy and using Fluent software to numerical simulation that the operating conditions and point. The results show that the blade pressure surface and suction surface pressure is low when the hydraulic turbine installation is added standard positive curvature of the guide vane and modified positive curvature of guide vane. Therefore, the efficiency of energy recovery is low. However, the pressure of negative curvature guide vane and symmetric guide vane added on hydraulic turbine installations is larger than that of the former ones, and it is conducive to working of runner. With the decreasing of guide vane opening, increasing of inlet angle, flow state gets significantly worse. Then, others obvious phenomena are that the reflux and horizontal flow appeared in blade pressure surface. At the same time, the vortex was formed in Leaf Road, leading to the loss of energy. Through analyzing the distribution of pressure, velocity, flow lines of over-current flow in the the back hydraulic conductivity components in above programs we can known that the hydraulic turbine installation added guide vane is more reasonable than without guide vanes, it is conducive to improve efficiency of energy conversion.

  17. Achievement report for fiscal 1989. Research and development of ceramic gas turbine (Regenerative single-shaft axial-flow turbine for cogeneration); 1989 nendo ceramic gas turbine no kenkyu kaihatsu seika hokokusho. Cogeneration yo saisei ichijikushiki jikuryu turbine

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-05-01

    With an objective to research and develop a 300-kW class regenerative single-shaft axial-flow turbine having inlet temperature of 1,350 degrees C and thermal efficiency of 42% or higher, activities were performed in the following three fields: 1) heat resistant ceramic members, 2) elementary technologies, and 3) studies on design, prototype fabrication, and operation. In Item 1, a mass production technology was discussed on stator blades and heat transfer pipes for a heat exchanger as the component manufacturing technology, and injection molding conditions were studied and mechanical strength measurement was performed on rotor blades of a separate type axial-flow turbine. In addition, a molding condition producing no cracks was discovered in an integrated type axial-flow turbine whose embedded section has a tapered shape, and the mass production technology was discussed. With regard to the bonding technology, preliminary discussions were given on bonding agents under a prerequisite that a bonding agent shall be used. In Item 2, detailed discussions were launched on the turbine, combustor, heat exchanger, and compressor, including shape decision on the turbine, for example, by using aerodynamic analysis, In Item 3, the basic design was performed following the conceptual design, and a metallic turbine was designed. (NEDO)

  18. Research on Darrieus-type hydraulic turbine for extra-low head hydropower utilization

    International Nuclear Information System (INIS)

    Furukawa, A; Watanabe, S; Okuma, K

    2012-01-01

    A Darrieus-type turbine has been investigated for extra-low head hydropower utilization. In the present paper, authors'research on Darrieus-type hydraulic turbine is briefly reviewed. The working principle of Darrieus turbine is explained with advantage of its simple structure, at first. Then the fluid-dynamic difference between rotating and linear motions of a blade in a uniform flow is clarified with guiding principle of high performance design of Darrieus turbine. Cavitation problem is also described. Next, effects of duct-casing, consisting of an intake, runner section and draft tube, are discussed and a simplified structure of Darrieus turbine is shown by installing the inlet nozzle. Finally, in the practical use, an adjustment of inlet nozzle section by lowering the inlet nozzle height is proposed when flow rate is varied temporally and seasonally.

  19. Experimental and analytical research on the aerodynamics of wind driven turbines. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Rohrbach, C.; Wainauski, H.; Worobel, R.

    1977-12-01

    This aerodynamic research program was aimed at providing a reliable, comprehensive data base on a series of wind turbine models covering a broad range of the prime aerodynamic and geometric variables. Such data obtained under controlled laboratory conditions on turbines designed by the same method, of the same size, and tested in the same wind tunnel had not been available in the literature. Moreover, this research program was further aimed at providing a basis for evaluating the adequacy of existing wind turbine aerodynamic design and performance methodology, for assessing the potential of recent advanced theories and for providing a basis for further method development and refinement.

  20. Engineering CAR-T cells.

    Science.gov (United States)

    Zhang, Cheng; Liu, Jun; Zhong, Jiang F; Zhang, Xi

    2017-01-01

    Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumors. CAR-T cells are generated by the T cells from patients' or donors' blood. After the T cells are expanded and genetically modified, they are reinfused into the patients. However, many challenges still need to be resolved in order for this technology to gain widespread adoption. In this review, we first discuss the structure and evolution of chimeric antigen receptors. We then report on the tools used for production of CAR-T cells. Finally, we address the challenges posed by CAR-T cells.

  1. Integration Research on Gas Turbine and Tunnel Kiln Combined System

    Science.gov (United States)

    Shi, Hefei; Ma, Liangdong; Liu, Mingsheng

    2018-04-01

    Through the integrated modeling of gas turbine and tunnel kiln combined system, a thermodynamic calculation method of combined system is put forward, and the combined system operation parameters are obtained. By this method, the optimization of the combined system is analyzed and the optimal configuration of the gas turbine is calculated. At the same time, the thermal efficiency of the combined system is analyzed, and the heat distribution and thermal efficiency of the system before and after the improvement are explained. Taking the 1500 kg/h ceramic production as an example, pointed out that if the tunnel kiln has a gas turbine with a power of 342 kw. The amount of electricity of the combined system that produced per unit volume of the fuel which consumes more than it used to will be 7.19 kwh, the system thermal efficiency will reach 57.49%, which higher than the individual gas turbine’s cycle thermal efficiency 20% at least.

  2. Evaluation of different inertial control methods for variable-speed wind turbines simulated by fatigue, aerodynamic, structures and turbulence (FAST)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xiao; Gao, Wenzhong; Scholbrock, Andrew; Muljadi, Eduard; Gevorgian, Vahan; Wang, Jianhui; Yan, Weihang; Zhang, Huaguang

    2017-10-18

    To mitigate the degraded power system inertia and undesirable primary frequency response caused by large-scale wind power integration, the frequency support capabilities of variable-speed wind turbines is studied in this work. This is made possible by controlled inertial response, which is demonstrated on a research turbine - controls advanced research turbine, 3-bladed (CART3). Two distinct inertial control (IC) methods are analysed in terms of their impacts on the grids and the response of the turbine itself. The released kinetic energy in the IC methods are determined by the frequency measurement or shaped active power reference in the turbine speed-power plane. The wind turbine model is based on the high-fidelity turbine simulator fatigue, aerodynamic, structures and turbulence, which constitutes the aggregated wind power plant model with the simplified power converter model. The IC methods are implemented over the baseline CART3 controller, evaluated in the modified 9-bus and 14-bus testing power grids considering different wind speeds and different wind power penetration levels. The simulation results provide various insights on designing such kinds of ICs. The authors calculate the short-term dynamic equivalent loads and give a discussion about the turbine structural loadings related to the inertial response.

  3. Adaptive Control of a Utility-Scale Wind Turbine Operating in Region 3

    Science.gov (United States)

    Frost, Susan A.; Balas, Mark J.; Wright, Alan D.

    2009-01-01

    Adaptive control techniques are well suited to nonlinear applications, such as wind turbines, which are difficult to accurately model and which have effects from poorly known operating environments. The turbulent and unpredictable conditions in which wind turbines operate create many challenges for their operation. In this paper, we design an adaptive collective pitch controller for a high-fidelity simulation of a utility scale, variable-speed horizontal axis wind turbine. The objective of the adaptive pitch controller in Region 3 is to regulate generator speed and reject step disturbances. The control objective is accomplished by collectively pitching the turbine blades. We use an extension of the Direct Model Reference Adaptive Control (DMRAC) approach to track a reference point and to reject persistent disturbances. The turbine simulation models the Controls Advanced Research Turbine (CART) of the National Renewable Energy Laboratory in Golden, Colorado. The CART is a utility-scale wind turbine which has a well-developed and extensively verified simulator. The adaptive collective pitch controller for Region 3 was compared in simulations with a bas celliansesical Proportional Integrator (PI) collective pitch controller. In the simulations, the adaptive pitch controller showed improved speed regulation in Region 3 when compared with the baseline PI pitch controller and it demonstrated robustness to modeling errors.

  4. FY 1998 annual report. Research and development on ceramic gas turbine (300kW class)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-04-01

    Research and development have been made on a small ceramic gas turbine which is high in efficiency, low in pollutant emission, capable of corresponding to different fuels, and can be utilized in cogeneration and/or movable electric power generation systems. Fundamental researches in developing and researching heat resistant ceramic parts have been carried out on a method for fabricating turbine nozzles using heat resistant silicon nitride, improvement in accuracy in fabricating combustors using the heat resistant silicon nitride, and casting of turbine blades made from sialon. In developing the devices, researches were made on reliability of bond between a ceramic blade and a metallic disk, air-fuel ratio in a combustor, distribution of fuel concentrations, fuel injection methods, reduction of loss in a diffuser in a compressor, and matching of the diffuser with an impeller. In addition, research and development were performed on a single shaft ceramic gas turbine for cogeneration and a double shaft ceramic gas turbine. Researches were executed on reliability of ceramic materials. (NEDO)

  5. Hydro-abrasive erosion of hydraulic turbines caused by sediment - a century of research and development

    Science.gov (United States)

    Felix, D.; Albayrak, I.; Abgottspon, A.; Boes, R. M.

    2016-11-01

    Hydro-abrasive erosion of hydraulic turbines is an economically important issue due to maintenance costs and production losses, in particular at high- and medium-head run-of- river hydropower plants (HPPs) on sediment laden rivers. In this paper, research and development in this field over the last century are reviewed. Facilities for sediment exclusion, typically sand traps, as well as turbine design and materials have been improved considerably. Since the 1980s, hard-coatings have been applied on Francis and Pelton turbine parts of erosion-prone HPPs and became state-of-the-art. These measures have led to increased times between overhauls and smaller efficiency reductions. Analytical, laboratory and field investigations have contributed to a better processes understanding and quantification of sediment-related effects on turbines. More recently, progress has been made in numerical modelling of turbine erosion. To calibrate, validate and further develop prediction models, more measurements from both physical model tests in laboratories and real-scale data from HPPs are required. Significant improvements to mitigate hydro-abrasive erosion have been achieved so far and development is ongoing. A good collaboration between turbine manufacturers, HPP operators, measuring equipment suppliers, engineering consultants, and research institutes is required. This contributes to the energy- and cost-efficient use of the worldwide hydropower potential.

  6. Variable-Speed Power-Turbine Research at Glenn Research Center

    Science.gov (United States)

    Welch, Gerard E.; McVetta, Ashlie B.; Stevens, Mark A.; Howard, Samuel A.; Giel, Paul W.; Ameri, Ali, A.; To, Waiming; Skoch, Gary J.; Thurman, Douglas R.

    2012-01-01

    The main rotors of the NASA Large Civil Tilt-Rotor (LCTR) notional vehicle operate over a wide speed-range, from 100 percent at takeoff to 54 percent at cruise. The variable-speed power turbine (VSPT) offers one approach by which to effect this speed variation. VSPT aerodynamics challenges include high work factors at cruise, wide (40 to 60 ) incidence-angle variations in blade and vane rows over the speed range, and operation at low Reynolds numbers. Rotordynamics challenges include potential responsiveness to shaft modes within the 50 percent VSPT speed-range. A research effort underway at NASA Glenn Research Center, intended to address these key aerodynamic and rotordynamic challenges, is described. Conceptual design and 3-D multistage RANS and URANS analyses, conducted internally and under contract, provide expected VSPT sizing, stage-count, performance and operability information, and maps for system studies. Initial steps toward experimental testing of incidence-tolerant blading in a transonic linear cascade are described, and progress toward development/improvement of a simulation capability for multistage turbines with low Reynolds number transitional flow is summarized. Preliminary rotordynamics analyses indicate that viable concept engines with 50 percent VSPT shaft-speed range. Assessments of potential paths toward VSPT component-level testing are summarized.

  7. Experimental and analytical research on the aerodynamics of wind driven turbines. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Rohrbach, C.; Wainauski, H.; Worobel, R.

    1977-12-01

    The successful development of reliable, cost competitive horizontal axis, propeller-type wind energy conversion systems (WECS) is strongly dependent on the availability of advanced technology for each of the system components. This aerodynamic research program was aimed at providing a reliable, comprehensive data base on a series of wind turbine models covering a broad range of the prime aerodynamic and geometric variables. Such data obtained under controlled laboratory conditions on turbines designed by the same method, of the same size, and tested in the same wind tunnel had not been available in the literature. Moreover, this research program was further aimed at providing a basis for evaluating the adequacy of existing wind turbine aerodynamic design and performance methodology, for assessing the potential of recent advanced theories and for providing a basis for further method development and refinement.

  8. Assessment of research needs for wind turbine rotor materials technology

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    Wind-driven power systems is a renewable energy technology that is still in the early stages of development. Wind power plants installed in early 1980s suffered structural failures chiefly because of incomplete understanding of wind forces (turbulent), in some cases because of poor product quality. Failures of rotor blades are now somewhat better understood. This committee has examined the experience base accumulated by wind turbines and the R and D programs sponsored by DOE. It is concluded that a wind energy system such as is described is within the capability of engineering practice; however because of certain gaps in knowledge, and the presence of only one major integrated manufacturer of wind power machines in the USA, a DOE R and D investment is still required.

  9. A Review of Research on Large Scale Modern Vertical Axis Wind Turbines at Uppsala University

    Directory of Open Access Journals (Sweden)

    Senad Apelfröjd

    2016-07-01

    Full Text Available This paper presents a review of over a decade of research on Vertical Axis Wind Turbines (VAWTs conducted at Uppsala University. The paper presents, among others, an overview of the 200 kW VAWT located in Falkenberg, Sweden, as well as a description of the work done on the 12 kW prototype VAWT in Marsta, Sweden. Several key aspects have been tested and successfully demonstrated at our two experimental research sites. The effort of the VAWT research has been aimed at developing a robust large scale VAWT technology based on an electrical control system with a direct driven energy converter. This approach allows for a simplification where most or all of the control of the turbines can be managed by the electrical converter system, reducing investment cost and need for maintenance. The concept features an H-rotor that is omnidirectional in regards to wind direction, meaning that it can extract energy from all wind directions without the need for a yaw system. The turbine is connected to a direct driven permanent magnet synchronous generator (PMSG, located at ground level, that is specifically developed to control and extract power from the turbine. The research is ongoing and aims for a multi-megawatt VAWT in the near future.

  10. Toward dialysis "a la carte".

    Science.gov (United States)

    Funck-Brentano, J L

    1987-12-01

    From the very beginning, the artificial kidney postponed the death of patients with end-stage renal failure. For years, owing to the performance of the machine, the patient was obliged to follow a severe diet in order to maintain good humoral and circulatory status. Now technological improvements allow "dialysis à la carte," whereby each individual achieves a better clinical status. The next step will be automation of the procedure to improve its security, mainly for dialysis performed at home.

  11. Contents of your cart

    African Journals Online (AJOL)

    Featured Country: South Africa, Featured Journal: Scientia Militaria: South African Journal of Military Studies. PROMOTING ACCESS TO AFRICAN RESEARCH. AJOL · Journals · Advanced Search · FAQ's · Register. Username. Password. Remember me. or Register · Find Journals on AJOL. HOW TO USE AJOL.

  12. Research and development of cooled turbine for aircraft engines. Koku engine yo reikyaku turbine no kenkyu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    Maya, T; Yamawaki, S [Ishikawajima-Harima Heavy Industries, Co. Ltd., Tokyo (Japan)

    1994-05-01

    For the turbine which is one of the principal elements of aircraft engine, progress in turbine use material development and cooling performance further heightened for the turbine are needed to grapple with the required heightening of turbine inlet temperature. In the present paper based on the turbine inlet temperature designed to be 1600[degree]C as a target, a two-dimensional model used for the turbine cooling performance test was structurally given together with the result of the above test which aimed at confirming the design calculation. As a result of cooling design for the turbine which was about 1600[degree]C in inlet temperature, the highest gas temperature was 1890 and 1470[degree]C on the stator blade and rotor blade, respectively. Both those blades were 0.66 and 0.62, respectively in cooling efficiency. To test the cooling performance, a two-dimensional cascade was tested with a doubly amplified model of cooling blade, the use of which could set its Reynolds number near that of the actual one. As compared with the actual operation, the test was made at low temperatures of 400 to 500[degree]C and low pressures of 0.02 to 0.03MPa. The test agreed with the design calculation in result. 4 refs., 8 figs.

  13. Insights into cytokine release syndrome and neurotoxicity after CD19-specific CAR-T cell therapy.

    Science.gov (United States)

    Gauthier, Jordan; Turtle, Cameron J

    2018-04-03

    T-cells engineered to express CD19-specific chimeric antigen receptors (CD19 CAR-T cells) can achieve high response rates in patients with refractory/relapsed (R/R) CD19+ hematologic malignancies. Nonetheless, the efficacy of CD19-specific CAR-T cell therapy can be offset by significant toxicities, such as cytokine release syndrome (CRS) and neurotoxicity. In this report of our presentation at the 2018 Second French International Symposium on CAR-T cells (CAR-T day), we describe the clinical presentations of CRS and neurotoxicity in a cohort of 133 adults treated with CD19 CAR-T cells at the Fred Hutchinson Cancer Research Center, and provide insights into the mechanisms contributing to these toxicities. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  14. Achievement report for fiscal 1989. Research and development of ceramic gas turbine (Portable regenerative two-shaft radial turbine for electric power generation); 1989 nendo ceramic gas turbine no kenkyu kaihatsu seika hokokusho. Kahanshiki hatsuden'yo saisei nijikushiki radial turbine

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-05-01

    Research and development has been advanced on a ceramic gas turbine with an output of 300-kW class, and having thermal efficiency of 42% or higher. Activities were performed in the following three fields: 1) research of heat resistant ceramic members, 2) research of elementary technologies, and 3) studies on design, prototype fabrication, and operation. In Item 1, forming and sintering were performed on a scroll of large size difficult for forming, an output turbine nozzle, a gas generator turbine nozzle, a shroud and back-shroud for same to extract technological problems. In addition, discussions were given on a method to bond the rotor of the gas generator turbine with the shaft. In Item 2, elementary tests were given on the rotary heat-storage type heat exchanger which has high relative technological difficulty and requires a great amount of time for development, wherein the thermal efficiency was improved by improving the flow velocity distribution. Furthermore, a combustor for the metal gas turbine was developed. Specifications were established for a test device required for hot spin tests of the gas generator turbine and output turbine, and part of the device was fabricated. In Item 3, detailed design was made for the metallic basic-type gas turbine to become the master form of the turbine to be developed. (NEDO)

  15. Des cartes dans la classe…

    Directory of Open Access Journals (Sweden)

    R. Gimeno

    1990-09-01

    Full Text Available La majorité des enseignants qui veulent faire des cartes — et les faire réaliser aux élèves — pour répondre aux exigences des instructions officielles, doivent surmonter leur manque de compétences en cartographie et en didactique ainsi que les difficultés propres aux logiciels de cartographie encore peu performants. Ces compétences et la réflexion qui les accompagne sont pourtant accessibles aux enfants de l’école élémentaire…

  16. Aerodynamic Research on the Midsection of a Long Turbine Blade

    Czech Academy of Sciences Publication Activity Database

    Šimurda, David; Luxa, Martin; Šafařík, Pavel; Synáč, J.

    2008-01-01

    Roč. 12, 3-4 (2008), s. 135-145 ISSN 1428-6394. [Polish National Conference of Fluid Mechanics /18./. Jastrzebia Góra, 21.09.2008-25.09.2008] R&D Projects: GA ČR GA101/07/1508 Institutional research plan: CEZ:AV0Z20760514 Keywords : high speed aerodynamics * blade cascade * experiment Subject RIV: BK - Fluid Dynamics

  17. Rolling Friction on a Wheeled Laboratory Cart

    Science.gov (United States)

    Mungan, Carl E.

    2012-01-01

    A simple model is developed that predicts the coefficient of rolling friction for an undriven laboratory cart on a track that is approximately independent of the mass loaded onto the cart and of the angle of inclination of the track. The model includes both deformation of the wheels/track and frictional torque at the axles/bearings. The concept of…

  18. Shopping cart injuries, entrapment, and childhood fatality.

    Science.gov (United States)

    Jensen, Lisbeth; Charlwood, Cheryl; Byard, Roger W

    2008-09-01

    Shopping carts may be associated with a variety of injuries, particularly in toddlers and young children. These usually relate to falls from carts or to tip-overs. Injuries that are sustained include hematomas/contusions, abrasions, lacerations, fractures, and fingertip amputations. Fatal episodes are uncommon and are usually due to blunt craniocerebral trauma from falls. A case involving a 19-month-old girl is reported who became entrapped when she inserted her head through the side frame of a cart that had been removed from a supermarket and left at her home address. Death was caused by neck compression. Although rare, the potential for lethal entrapment during unsupervised play means that the presence of stray shopping carts at private residences and in public places, including playgrounds and parks, is of concern. Strategies, such as coin deposits, should be encouraged to assist in the return of such carts to supermarkets.

  19. Some research and development on power plants with helium gas turbine units

    International Nuclear Information System (INIS)

    Kaplan, M.P.

    1983-01-01

    Research and development projects pursued at the S. M. Kirov Kharkov Turbine Factory Production Association for Nuclear Turbomachinery Manufacturing have probed into prospective use of helium as the working medium in nuclear power facilities. The projects under study are compared mainly in terms of heat efficiency. Solutions are also being sought for problems centering around high efficiency in helium turbocompressors combined with shortening of axial dimensions. Different types of power plants are being compared with attention given to features of the flow passages of turbocompressors. The projects were developed for helium temperatures and pressures downstream of the reactor 950 0 C and 4.8 MPa, and thermal reactor output 2250 MW(th). The reactor is assumed to be served by two turbine plants in the turbocompressor designs

  20. Research on the flow field of undershot cross-flow water turbines using experiments and numerical analysis

    International Nuclear Information System (INIS)

    Nishi, Y; Inagaki, T; Li, Y; Omiya, R; Hatano, K

    2014-01-01

    The purpose of this research is to develop a water turbine appropriate for low-head open channels in order to effectively utilize the unused hydropower energy of rivers and agricultural waterways. The application of the cross-flow runner to open channels as an undershot water turbine has come under consideration and, to this end, a significant simplification was attained by removing the casings. However, the flow field of undershot cross-flow water turbines possesses free surfaces. This means that with the variation in the rotational speed, the water depth around the runner will change and flow field itself is significantly altered. Thus it is necessary to clearly understand the flow fields with free surfaces in order to improve the performance of this turbine. In this research, the performance of this turbine and the flow field were studied through experiments and numerical analysis. The experimental results on the performance of this turbine and the flow field were consistent with the numerical analysis. In addition, the inlet and outlet regions at the first and second stages of this water turbine were clarified

  1. Research on rotational speed to the influence of pump as turbine

    International Nuclear Information System (INIS)

    Yang, S S; Kong, F Y; Jiang, W M; Qu, X Y

    2012-01-01

    Due to the problem of lacking hydraulic control devices, pump as turbine (PAT) has the disadvantage of optimum operation only within a small range discharge where the net head utilization and operating efficiency are the highest. Variable speed operation offers a good solution to this problem. Pump manufactures normally do not provide performance curves of their pumps working as turbines, especially when working at variable speed condition. Therefore, establishing a correlation between PAT's performance curve and rotational speed is essential. In this paper, a method of predicting PAT's performance at different rotational speeds was first developed using theoretical analysis. In the second step, a single stage centrifugal pump operated as a turbine was tested at different rotational speeds. Typical performance curves of PAT operating at variable speed condition were acquired. Finally computational fluid dynamics (CFD) had been used in this research. The accuracy of CFD prediction was proved when compared with experimental data. The validity of presented method by theoretical analysis was validated using test and CFD results.

  2. The aeroelasticity research project 2004[Wind turbines]; Forskning i aeroelasticitet EFP-2004

    Energy Technology Data Exchange (ETDEWEB)

    Bak, C.

    2005-05-01

    The report presents the results of the project ''Programme for Applied Aeroelasticity'', the Danish Energy Research Programme 2004. The main results are: 1) Based on an analysis of the NREL/NASA experiment with a wind turbine in a wind tunnel a new model is formulated for 3D corrections of profile data for aeroelastic codes. Use of the model on three rotors suggests that the load distribution is determined more correctly than in existing 3D models. 2) A near-wake model, originally developed for aerodynamic loads on helicopter rotors, is implemented for calculating dynamic induction on wind turbine rotors. The model has several advantages to the other normally used model BEM. 3) A detailed comparison of the aeroelastic models FLEX5 and HAWC shows that there are no model differences that can result in large differences in the calculated loads. The comparison shows that differences in the calculated loads are due to the use of the models. 4) A model for pitch-servo dynamics on a modern wind turbine is formed and implemented in HAWC2. The conclusion from analysis of the importance of the pitch-servo characteristics showed that coupling between structure/aerodynamics and pitch actuator may be of importance, especially for the loads on the actuator itself. Also large deflections are coupled to the pitch moment and thus also to torsion of the wing and wing bearing. 5) An un-linear stability analysis has been performed in which periodic loads are included and compared to a linear analysis used in HAWCStab. For a profile with near zero aerodynamic damping in one oscillation direction, the aerodynamic force in this direction depends mostly of the square on the profile's speed. The linear damping is changed only a little by the profile's forced oscillation. It is assumed that the present HAWCStab can predict the mean aeroelastic damping for turbines' oscillations in operation. (LN)

  3. EPRI research program NDE techniques for crack initiation of steam turbine rotor

    International Nuclear Information System (INIS)

    Goto, T.; Kimura, J.; Kawamoto, K.; Kadoya, Y.; Viswanathan, R.

    1990-01-01

    EPRI RP 2481-8 aims at the development of nondestructive methods for the life assessment of steam turbine rotor for its crack initiation caused by creep and/or fatigue. As a part of the research project, the demonstration of the state of the art NDE techniques was conducted during June to August of 1988 at EPRI NDE Center, Charlotte, N.C. by Mitsubishi Heavy Industries, Ltd. using four rotors retired after long term service (16-22x10 4 hr). This paper introduces the results of the demonstration

  4. Development of High-Powered Steam Turbines by OAO NPO Central Research and Design Institute for Boilers and Turbines

    Science.gov (United States)

    Mikhailov, V. E.; Khomenok, L. A.; Kovalev, I. A.

    2018-01-01

    The article provides an overview of the developments by OAO NPO TsKTI aimed at improvement of components and assemblies of new-generation turbine plants for ultra-supercritical steam parameters to be installed at the power-generating facilities in service. The list of the assemblies under development includes cylinder shells, the cylinder's flow paths and rotors, seals, bearings, and rotor cooling systems. The authors consider variants of the shafting-cylinder configurations for which advanced high-pressure and intermediate-pressure cylinders with reactive blading and low-pressure cylinders of conventional design and with counter-current steam flows are proposed and high-pressure rotors, which can increase the economic efficiency and reduce the overall turbine plant dimensions. Materials intended for the equipment components that operate at high temperatures and a steam cooling technique that allows the use of cheaper steel grades owing to the reduction in the metal's working temperature are proposed. A new promising material for the bearing surfaces is described that enables the operation at higher unit pressures. The material was tested on a full-scale test bench at OAO NPO TsKTI and a turbine in operation. Ways of controlling the erosion of the blades in the moisture-steam turbine compartments by the steam heating of the hollow guide blades are considered. To ensure the dynamic stability of the shafting, shroud and diaphragm seals that prevent the development of the destabilizing circulatory forces of the steam flow were devised and trialed. Advanced instrumentation and software are proposed to monitor the condition of the blading and thermal stresses under transient conditions, to diagnose the vibration processes, and to archive the obtained data. Attention is paid to the normalization of the electromagnetic state of the plant in order to prevent the electrolytic erosion of the plant components. The instrumentation intended for monitoring the relevant electric

  5. Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension

    Directory of Open Access Journals (Sweden)

    I. Janiuk

    2015-04-01

    Full Text Available Recent biological advances make it possible to discover new peptides associated with hypertension. The cocaine- and amphetamine-regulated transcript (CART is a known factor in appetite and feeding behaviour. Various lines of evidence suggest that this peptide participates not only in control of feeding behaviour but also in the regulation of the cardiovascular and sympathetic systems and blood pressure. The role of CART in blood pressure regulation led us to undertake a study aimed at analysing quantitative changes in CART-containing cells in urinary bladders (UB of rats with renovascular hypertension. We used the Goldblatt model of arterial hypertension (two-kidney, one clip to evaluate quantitative changes. This model provides researchers with a commonly used tool to analyse the renin-angiotensin system of blood pressure control and, eventually, to develop drugs for the treatment of chronic hypertension. The study was performed on sections of urinary bladders of rats after 3-, 14-, 28-, 42 and 91 days from hypertension induction. Immunohistochemical identification of CART cells was performed on paraffin for the UBs of all the study animals. CART was detected in the endocrine cells, especially numerous in the submucosa and muscularis layers, with a few found in the transitional epithelium and only occasionally in serosa. Hypertension significantly increased the number of CART-positive cells in the rat UBs. After 3 and 42 days following the procedure, statistically significantly higher numbers of CART-positive cells were identified in comparison with the control animals. The differences between the hypertensive rats and the control animals concerned not only the number density of CART-immunoreactive cells but also their localization. After a 6-week period, each of the rats subjected to the renal artery clipping procedure developed stable hypertension. CART appeared in numerous transitional epithelium cells. As this study provides novel findings

  6. Achievement report for fiscal 1992. Research and development of ceramic gas turbine (Portable regenerative double-shaft ceramic gas turbine for portable power generation); 1992 nendo ceramic gas turbine no kenkyu kaihatsu seika hokokusho. Kahanshiki hatsuden'yo saiseishiki ceramic gas turbine

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-05-01

    Research and development has been advanced on a ceramic gas turbine (CGT) with an output of 300-kW class and thermal efficiency of 42% or higher. Activities were performed in the following three fields: 1) research of heat resistant ceramic members, 2) research of elementary technologies, and 3) studies on design, prototype fabrication, and operation. In Item 1, research was performed on forming the heat resistant ceramic members, and all-ceramic members constituting the basic type gas turbine were fabricated. Improvements were given on the problems discovered in the heat shock test, and the hot spin test. In Item 2, elementary researches were made on the basic technologies for the ceramic gas turbine, such as on the heat exchanger, combustor, and ceramic turbine, wherein discussions were given on improvement of mechanical strength and performance. In Item 3, design and prototype fabrication were performed on the basic type ceramic gas turbine, based on the results of research operations on the basic type (metallic gas turbine). Adjustment operations were launched on some of the components. (NEDO)

  7. Getting started with OpenCart module development

    CERN Document Server

    Nepali, Rupak

    2013-01-01

    Written as a step-by-step guide, Getting Started with OpenCart Module Development will teach you all you need to know about OpenCart, from custom extensions to module development.This book is for developers who want to develop OpenCart extensions and for those who want to learn more about the code workflow of OpenCart. Basic knowledge of OpenCart would be an added advantage.

  8. Aerodynamic Research of the Experimental Prototype of the Variable Geometry Wind Turbine

    Directory of Open Access Journals (Sweden)

    Urbahs Aleksandrs

    2017-12-01

    Full Text Available The aim of this research is to develop a vertical rotation axis variable geometry wind turbine (WT. The experimental prototype is being manufactured with the help of CAM (Computer-aided manufacturing technologies – computer-based preparation of the product manufacturing process. The Institute of Aeronautics of Riga Technical University is using CNC (Computer Numerical Control machines for manufacturing the innovative WT and its components. The aerodynamic research has been done in T-4 wind tunnel at an air flow rate from 5 m/s to 30 m/s. The power increase of the variable geometry WT is a topical issue. Installation of such WTs in wind farms is possible and is subject to further research.

  9. Fiscal 1975 Sunshine Project research report. General research on hydrogen energy subsystems and their peripheral technologies (Research on hydrogen gas turbine); 1975 nendo suiso riyo subsystem no sogoteki kento to shuhen gijutsu ni kansuru kenkyu seika hokokusho. Suiso gas turbine ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1976-03-31

    This research aims at establishment of the meaning of using hydrogen as gas turbine fuel in the hydrogen energy system and various conditions for hydrogen gas turbines, and approaches to the feasibility study and R and D of hydrogen gas turbines in the future. In fiscal 1975, researches were made on (1) feasibility study on hydrogen-oxygen gas turbine, (2) establishment of various conditions for technical, social and economic realization of hydrogen gas turbines in the total energy system, and (3) study on technical troubles to be solved for realization of hydrogen gas turbines. For the above researches, study was made on hydrogen combustion based on the hydrogen combustion test result of gas mixture including hydrogen, and on the feasibility of aphodid cycle. In addition, study on the applicability of hydrogen-oxygen gas turbines, comparative study on hydrogen-oxygen gas turbine, MHD power generation and fuel cell, and the future prospect of hydrogen gas turbines for ships were made to place this hydrogen gas turbine. (NEDO)

  10. Resonant Vibrations Resulting from the Re-Engineering of a Constant-Speed 2-Bladed Turbine to a Variable-Speed 3-Bladed Turbine

    Energy Technology Data Exchange (ETDEWEB)

    Fleming, P.; Wright, A. D.; Finersh, L. J.

    2010-12-01

    The CART3 (Controls Advanced Research Turbine, 3-bladed) at the National Wind Technology Center has recently been converted from a 2-bladed constant speed machine to a 3-bladed variable speed machine designed specically for controls research. The purpose of this conversion was to develop an advanced controls field-testing platform which has the more typical 3-bladed configuration. A result of this conversion was the emergence of several resonant vibrations, some of which initially prevented operation of the turbine until they could be explained and resolved. In this paper, the investigations into these vibrations are presented as 'lessons-learned'. Additionally, a frequency-domain technique called waterfall plotting is discussed and its usefulness in this research is illustrated.

  11. Wind power - research and development. The wind turbine industry's view of the promotion of state-supported research and development

    International Nuclear Information System (INIS)

    Kroh, S.

    1995-10-01

    The windmill industry in Denmark is currently confronted with making a choice between competing technologies so that the role of the stimulus of state subsidies for research has lately increased in importance. The Ministry of Energy, it is claimed, must be aware of this as possibilities for making use of research results are dictated by the market and competition. The industry is not sympathetic to the idea of state research contracts with specified goals for which manufacturers must produce a technical solution. Consultancy firms should work towards solving general problems which could help the industry as a whole. Wind turbines which are cheap to produce and operate are of more interest to industry than those which are technologically advanced or of a lighter construction. It is not thought to be advantageous to concentrate the allocation of subsidies on one key project chosen by the Ministry itself, such as the current intense interest in turbine blades. Aerodynamics, noise pollution and materials are considered as more vital areas for research. A special interest in smaller windmills is not currently relevant. Evaluations of the quality of research projects demanding subsidies should be more critical. A detailed list of subjects within this field which are considered as being relevant for research is given. The Danish windmill industry advises a centralized wind power research institution and a gradual shift of the test station at Risoe National Laboratory to Jutland as wind conditions at Risoe are not considered satisfactory. A better communication between Risoe test station and the wind power industry is recommended. (AB)

  12. Materials and Structures Research for Gas Turbine Applications Within the NASA Subsonic Fixed Wing Project

    Science.gov (United States)

    Hurst, Janet

    2011-01-01

    A brief overview is presented of the current materials and structures research geared toward propulsion applications for NASA s Subsonic Fixed Wing Project one of four projects within the Fundamental Aeronautics Program of the NASA Aeronautics Research Mission Directorate. The Subsonic Fixed Wing (SFW) Project has selected challenging goals which anticipate an increasing emphasis on aviation s impact upon the global issue of environmental responsibility. These goals are greatly reduced noise, reduced emissions and reduced fuel consumption and address 25 to 30 years of technology development. Successful implementation of these demanding goals will require development of new materials and structural approaches within gas turbine propulsion technology. The Materials and Structures discipline, within the SFW project, comprise cross-cutting technologies ranging from basic investigations to component validation in laboratory environments. Material advances are teamed with innovative designs in a multidisciplinary approach with the resulting technology advances directed to promote the goals of reduced noise and emissions along with improved performance.

  13. Numerical Research on Effects of Splitter Blades to the Influence of Pump as Turbine

    Directory of Open Access Journals (Sweden)

    Yang Sun-Sheng

    2012-01-01

    Full Text Available Centrifugal pumps can be operated in reverse as small hydropower recovery turbines and are cheaper than bespoke turbines due to their ease of manufacture. Splitter blades technique is one of the techniques used in flow field optimization and performance enhancement of rotating machinery. To understand the effects of splitter blades to the steady and unsteady influence of PAT, numerical research was performed. 3D Navier-Stokes solver CFX was used in the performance prediction and analysis of PAT’s performance. Results show that splitter blades have a positive impact on PAT’s performance. With the increase of splitter blades, its required pressure head is dropped and its efficiency is increased. Unsteady pressure field analysis and comparison show that the unsteady pressure field within PAT is improved when splitter blades are added to impeller flow passage. To verify the accuracy of numerical prediction methods, an open PAT test rig was built at Jiangsu University. The PAT was manufactured and tested. Comparison between experimental and numerical results shows that the discrepancy between numerical and experimental results is acceptable. CFD can be used in the performance prediction and optimization of PAT.

  14. Research on the aerodynamic characteristics of a lift drag hybrid vertical axis wind turbine

    Directory of Open Access Journals (Sweden)

    Xiaojing Sun

    2016-01-01

    Full Text Available Compared with a drag-type vertical axis wind turbines, one of the greatest advantages for a lift-type vertical axis wind turbines is its higher power coefficient (Cp. However, the lift-type vertical axis wind turbines is not a self-starting turbine as its starting torque is very low. In order to combine the advantage of both the drag-type and the lift-type vertical axis wind turbines, a lift drag hybrid vertical axis wind turbines was designed in this article and its aerodynamics and starting performance was studied in detail with the aid of computational fluid dynamics simulations. Numerical results indicate that the power coefficient of this lift drag hybrid vertical axis wind turbines declines when the distance between its drag-type blades and the center of rotation of the turbine rotor increases, whereas its starting torque can be significantly improved. Studies also show that unlike the lift-type vertical axis wind turbines, this lift drag hybrid-type vertical axis wind turbines could be able to solve the problem of low start-up torque. However, the installation position of the drag blade is very important. If the drag blade is mounted very close to the spindle, the starting torque of the lift drag hybrid-type vertical axis wind turbines may not be improved at all. In addition, it has been found that the power coefficient of the studied vertical axis wind turbines is not as good as expected and possible reasons have been provided in this article after the pressure distribution along the surfaces of the airfoil-shaped blades of the hybrid turbine was analyzed.

  15. The Department of Energy (DOE) research program in structural analysis of vertical-axis wind turbines

    Science.gov (United States)

    Sullivan, W. N.

    The Darrieus-type Vertical Axis Wind Turbine (VAWT) presents a variety of unusual structural problems to designers. The level of understanding of these structural problems governs, to a large degree, the success or failure of today's rotor designs. A survey is presented of the technology available for rotor structural design with emphasis on the DOE research program now underway. Itemizations are included of the major structural issues unique to the VAWT along with discussion of available analysis techniques for each problem area. It is concluded that tools are available to at least approximately address the most important problems. However, experimental data for confirmation is rather limited in terms of volume and the range of rotor configurations tested.

  16. Progress in Protective Coatings for Aircraft Gas Turbines: A Review of NASA Sponsored Research

    Science.gov (United States)

    Merutka, J. P.

    1981-01-01

    Problems associated with protective coatings for advanced aircraft gas turbines are reviewed. Metallic coatings for preventing titanium fires in compressors are identified. Coatings for turbine section are also considered, Ductile aluminide coatings for protecting internal turbine-blade cooling passage surface are also identified. Composite modified external overlay MCrAlY coatings deposited by low-pressure plasma spraying are found to be better in surface protection capability than vapor deposited MCrAlY coatings. Thermal barrier coating (TBC), studies are presented. The design of a turbine airfoil is integrated with a TBC, and computer-aided manufacturing technology is applied.

  17. Cumulative effects of wind turbines. Volume 2: Report on qualitative public attitude research in mid-Wales

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    This report summarises the results of research to develop a planning tool for assessing the cumulative effect of wind turbines carried out in Montgomeryshire through contact with those involved in wind farms, and those living near and further away from the wind turbine arrays. Topics examined included people's feeling about wind farms, noise, experience with wind farm developers, availability of related jobs, awareness of income to farmers from wind farms, developers' contributions to local funds, awareness of government policy, appreciation of wind as a resource, and the effects on tourism.

  18. Research and development of improved efficiency small steam turbines (IESST). Technical progress report, Phase I, 16 April-31 December 1979

    Energy Technology Data Exchange (ETDEWEB)

    Choate, D.M.; Tuttle, A.H.

    1980-01-01

    Product Statistical Bulletins of the National Electrical Manufacturers Association (NEMA) and Turbodyne's shipment records over a 10-y period were researched to determine quantities installed and to define general parameters of design. Engineering studies were conducted to determine the optimum turbine design to meet the defined design parameters. Two conceptual designs plus an added variation of one design were completed together with designs of gearing required to provide speeds compatible with driven equipment speeds. The calculated performance of the recommended design and currently available small steam turbines were compared and a life cycle cost analysis was conducted to determine the economic competitiveness of the new design.

  19. Cumulative effects of wind turbines. Volume 2: Report on qualitative public attitude research in mid-Wales

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    This report summarises the results of research to develop a planning tool for assessing the cumulative effect of wind turbines carried out in Montgomeryshire through contact with those involved in wind farms, and those living near and further away from the wind turbine arrays. Topics examined included people's feeling about wind farms, noise, experience with wind farm developers, availability of related jobs, awareness of income to farmers from wind farms, developers' contributions to local funds, awareness of government policy, appreciation of wind as a resource, and the effects on tourism.

  20. GLYCAN-DIRECTED CAR-T CELLS.

    Science.gov (United States)

    Steentoft, Catharina; Migliorini, Denis; King, Tiffany R; Mandel, Ulla; June, Carl H; Posey, Avery D

    2018-01-23

    Cancer immunotherapy is rapidly advancing in the treatment of a variety of hematopoietic cancers, including pediatric acute lymphoblastic leukemia and diffuse large B cell lymphoma, with chimeric antigen receptor (CAR)-T cells. CARs are genetically encoded artificial T cell receptors that combine the antigen specificity of an antibody with the machinery of T cell activation. However, implementation of CAR technology in the treatment of solid tumors has been progressing much slower. Solid tumors are characterized by a number of challenges that need to be overcome, including cellular heterogeneity, immunosuppressive tumor microenvironment (TME), and, in particular, few known cancer-specific targets. Post-translational modifications that differentially occur in malignant cells generate valid cell surface, cancer-specific targets for CAR-T cells. We previously demonstrated that CAR-T cells targeting an aberrant O-glycosylation of MUC1, a common cancer marker associated with changes in cell adhesion, tumor growth, and poor prognosis, could control malignant growth in mouse models. Here, we discuss the field of glycan-directed CAR-T cells and review the different classes of antibodies specific for glycan-targeting, including the generation of high affinity O-glycopeptide antibodies. Finally, we discuss historic and recently investigated glycan targets for CAR-T cells and provide our perspective on how targeting the tumor glycoproteome and/or glycome will improve CAR-T immunotherapy. © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  1. A short review of recent research activities for characterization of aerodynamic optimization of vertical axis wind turbines

    NARCIS (Netherlands)

    Rezaeiha, A.; Kalkman, I.; Blocken, B.J.E.

    2017-01-01

    There is a growing interest in wind energy harvesting in the built environment. Vertical axis wind turbines (VAWT) seem to represent an ideal candidate for this purpose due to their omni-directional operation. However, as a result of a comparatively small amount of research on VAWTs during the last

  2. Clinical trials of CAR-T cells in China

    Directory of Open Access Journals (Sweden)

    Bingshan Liu

    2017-10-01

    Full Text Available Abstract Novel immunotherapeutic agents targeting tumor-site microenvironment are revolutionizing cancer therapy. Chimeric antigen receptor (CAR-engineered T cells are widely studied for cancer immunotherapy. CD19-specific CAR-T cells, tisagenlecleucel, have been recently approved for clinical application. Ongoing clinical trials are testing CAR designs directed at novel targets involved in hematological and solid malignancies. In addition to trials of single-target CAR-T cells, simultaneous and sequential CAR-T cells are being studied for clinical applications. Multi-target CAR-engineered T cells are also entering clinical trials. T cell receptor-engineered CAR-T and universal CAR-T cells represent new frontiers in CAR-T cell development. In this study, we analyzed the characteristics of CAR constructs and registered clinical trials of CAR-T cells in China and provided a quick glimpse of the landscape of CAR-T studies in China.

  3. Clinical trials of CAR-T cells in China.

    Science.gov (United States)

    Liu, Bingshan; Song, Yongping; Liu, Delong

    2017-10-23

    Novel immunotherapeutic agents targeting tumor-site microenvironment are revolutionizing cancer therapy. Chimeric antigen receptor (CAR)-engineered T cells are widely studied for cancer immunotherapy. CD19-specific CAR-T cells, tisagenlecleucel, have been recently approved for clinical application. Ongoing clinical trials are testing CAR designs directed at novel targets involved in hematological and solid malignancies. In addition to trials of single-target CAR-T cells, simultaneous and sequential CAR-T cells are being studied for clinical applications. Multi-target CAR-engineered T cells are also entering clinical trials. T cell receptor-engineered CAR-T and universal CAR-T cells represent new frontiers in CAR-T cell development. In this study, we analyzed the characteristics of CAR constructs and registered clinical trials of CAR-T cells in China and provided a quick glimpse of the landscape of CAR-T studies in China.

  4. Aerodynamics of Wind Turbines

    DEFF Research Database (Denmark)

    Hansen, Martin Otto Laver

    Aerodynamics of Wind Turbines is the established essential text for the fundamental solutions to efficient wind turbine design. Now in its second edition, it has been entirely updated and substantially extended to reflect advances in technology, research into rotor aerodynamics and the structural...... response of the wind turbine structure. Topics covered include increasing mass flow through the turbine, performance at low and high wind speeds, assessment of the extreme conditions under which the turbine will perform and the theory for calculating the lifetime of the turbine. The classical Blade Element...... Momentum method is also covered, as are eigenmodes and the dynamic behavior of a turbine. The new material includes a description of the effects of the dynamics and how this can be modeled in an aeroelastic code, which is widely used in the design and verification of modern wind turbines. Further...

  5. Loadings in thermal barrier coatings of jet engine turbine blades an experimental research and numerical modeling

    CERN Document Server

    Sadowski, Tomasz

    2016-01-01

    This book discusses complex loadings of turbine blades and protective layer Thermal Barrier Coating (TBC), under real working airplane jet conditions. They obey both multi-axial mechanical loading and sudden temperature variation during starting and landing of the airplanes. In particular, two types of blades are analyzed: stationary and rotating, which are widely applied in turbine engines produced by airplane factories.

  6. Achievement report for fiscal 1998. Research and development of ceramic gas turbine (Regenerative single-shaft ceramic gas turbine for cogeneration); 1998 nendo ceramic gas turbine no kenkyu kaihatsu seika hokokusho. Cogeneration yo saiseishiki ichijiku ceramic gas turbine

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-05-01

    Efforts are exerted to develop a 300kW-class ceramic gas turbine with a turbine inlet temperature of 1350 degrees C and thermal efficiency of 42% or higher. The soundness in strength of the ceramic rotor blades and their fastening structure is confirmed. Rotor blade cushion thickness is found to decrease in start-and-stop repetitions in the initial period, but not thereafter. The exhaust diffuser and exhaust path shape are studied and improved for an increase in output, which improves turbine efficiency by 1.7%. Under the operating conditions of 1350 degrees C and full load, NOx emissions and combustion efficiency prove to be 5.6ppm and 99.9%. Even in the case using a large-diameter liner with its combustion efficiency under light load improved, the ultimate target value is achieved. Studies are further conducted on centrifugal stage loss reduction towards the ultimate goal set for the compressor. The diffuser shape is improved and the shroud clearance is reduced, and insulation efficiency of 81.1% is attained at the designing stage. In a test run of a pilot ceramic gas turbine in which temperature finally arrives at 1350 degrees C, engine thermal efficiency of 35% and shaft output of 282kW are achieved. (NEDO)

  7. Gas turbine

    International Nuclear Information System (INIS)

    Yang, Ok Ryong

    2004-01-01

    This book introduces gas turbine cycle explaining general thing of gas turbine, full gas turbine cycle, Ericson cycle and Brayton cycle, practical gas turbine cycle without pressure loss, multiaxial type gas turbine cycle and special gas turbine cycle, application of basic theory on a study on suction-cooling gas turbine cycle with turbo-refrigerating machine using the bleed air, and general performance characteristics of the suction-cooling gas turbine cycle combined with absorption-type refrigerating machine.

  8. E-Commerce Performance. Shopping Cart Key Performance Indicators

    Directory of Open Access Journals (Sweden)

    Mihaela I. MUNTEAN

    2016-01-01

    Full Text Available In an e-commerce performance framework is important to identify the key performance indicators that measure success and together provide the greatest context into the business perfor-mance. Shopping carts are an essential part of ecommerce, a minimal set of key performance indicators being the subject of our debate. The theoretical approach is sustained by a case study, an e-shop implemented using PHP and MySQL, for simulating main business processes within the considered performance framework. Our approach opens a perspective for future research using additional indicators in order to properly evaluate the global performance of any e-shop.

  9. Implementation of a generalized actuator line model for wind turbine parameterization in the Weather Research and Forecasting model

    Energy Technology Data Exchange (ETDEWEB)

    Marjanovic, Nikola [Department of Civil and Environmental Engineering, University of California, Berkeley, MC 1710, Berkeley, California 94720-1710, USA; Atmospheric, Earth and Energy Division, Lawrence Livermore National Laboratory, PO Box 808, L-103, Livermore, California 94551, USA; Mirocha, Jeffrey D. [Atmospheric, Earth and Energy Division, Lawrence Livermore National Laboratory, PO Box 808, L-103, Livermore, California 94551, USA; Kosović, Branko [Research Applications Laboratory, Weather Systems and Assessment Program, University Corporation for Atmospheric Research, PO Box 3000, Boulder, Colorado 80307, USA; Lundquist, Julie K. [Department of Atmospheric and Oceanic Sciences, University of Colorado, Boulder, Campus Box 311, Boulder, Colorado 80309, USA; National Renewable Energy Laboratory, 15013 Denver West Parkway, Golden, Colorado 80401, USA; Chow, Fotini Katopodes [Department of Civil and Environmental Engineering, University of California, Berkeley, MC 1710, Berkeley, California 94720-1710, USA

    2017-11-01

    A generalized actuator line (GAL) wind turbine parameterization is implemented within the Weather Research and Forecasting model to enable high-fidelity large-eddy simulations of wind turbine interactions with boundary layer flows under realistic atmospheric forcing conditions. Numerical simulations using the GAL parameterization are evaluated against both an already implemented generalized actuator disk (GAD) wind turbine parameterization and two field campaigns that measured the inflow and near-wake regions of a single turbine. The representation of wake wind speed, variance, and vorticity distributions is examined by comparing fine-resolution GAL and GAD simulations and GAD simulations at both fine and coarse-resolutions. The higher-resolution simulations show slightly larger and more persistent velocity deficits in the wake and substantially increased variance and vorticity when compared to the coarse-resolution GAD. The GAL generates distinct tip and root vortices that maintain coherence as helical tubes for approximately one rotor diameter downstream. Coarse-resolution simulations using the GAD produce similar aggregated wake characteristics to both fine-scale GAD and GAL simulations at a fraction of the computational cost. The GAL parameterization provides the capability to resolve near wake physics, including vorticity shedding and wake expansion.

  10. Hypothalamic CART is a new anorectic peptide regulated by leptin.

    Science.gov (United States)

    Kristensen, P; Judge, M E; Thim, L; Ribel, U; Christjansen, K N; Wulff, B S; Clausen, J T; Jensen, P B; Madsen, O D; Vrang, N; Larsen, P J; Hastrup, S

    1998-05-07

    The mammalian hypothalamus strongly influences ingestive behaviour through several different signalling molecules and receptor systems. Here we show that CART (cocaine- and amphetamine-regulated transcript), a brain-located peptide, is a satiety factor and is closely associated with the actions of two important regulators of food intake, leptin and neuropeptide Y. Food-deprived animals show a pronounced decrease in expression of CART messenger RNA in the arcuate nucleus. In animal models of obesity with disrupted leptin signalling, CART mRNA is almost absent from the arcuate nucleus. Peripheral administration of leptin to obese mice stimulates CART mRNA expression. When injected intracerebroventricularly into rats, recombinant CART peptide inhibits both normal and starvation-induced feeding, and completely blocks the feeding response induced by neuropeptide Y. An antiserum against CART increases feeding in normal rats, indicating that CART may be an endogenous inhibitor of food intake in normal animals.

  11. Research on efficiency test of a turbine in Khan Khwar hydropower station

    International Nuclear Information System (INIS)

    Zhang, H K; Liang, Z; Deng, M G; Liu, X B; Wang, H Y; Liu, D M

    2012-01-01

    The efficiency test is an important indicator to evaluate the energy conversion performance of a hydraulic turbine. For hydropower stations which do not have the direct flow measurement conditions, whether the characteristic curve of a turbine obtained through similarity theory conversion by using the comprehensive characteristic curve of the turbine can correctly reflect the operating performance of the prototype unit is a key issue in this industry. By taking the No.1 unit of Khan Khwar hydropower station as the example, the efficiency test of this turbine was studied on the site, including the measurement method of test parameters, the configuration of the computer test system, as well as the processing and analysis of test data.

  12. CAR-T cell therapy in gastrointestinal tumors and hepatic carcinoma: From bench to bedside.

    Science.gov (United States)

    Zhang, Qi; Zhang, Zimu; Peng, Meiyu; Fu, Shuyu; Xue, Zhenyi; Zhang, Rongxin

    2016-01-01

    The chimeric antigen receptor (CAR) is a genetically engineered receptor that combines a scFv domain, which specifically recognizes the tumor-specific antigen, with T cell activation domains. CAR-T cell therapies have demonstrated tremendous efficacy against hematologic malignancies in many clinical trials. Recent studies have extended these efforts to the treatment of solid tumors. However, the outcomes of CAR-T cell therapy for solid tumors are not as remarkable as the outcomes have been for hematologic malignancies. A series of hurdles has arisen with respect to CAR-T cell-based immunotherapy, which needs to be overcome to target solid tumors. The major challenge for CAR-T cell therapy in solid tumors is the selection of the appropriate specific antigen to demarcate the tumor from normal tissue. In this review, we discuss the application of CAR-T cells to gastrointestinal and hepatic carcinomas in preclinical and clinical research. Furthermore, we analyze the usefulness of several specific markers in the study of gastrointestinal tumors and hepatic carcinoma.

  13. Active-passive vibration absorber of beam-cart-seesaw system with piezoelectric transducers

    Science.gov (United States)

    Lin, J.; Huang, C. J.; Chang, Julian; Wang, S.-W.

    2010-09-01

    In contrast with fully controllable systems, a super articulated mechanical system (SAMS) is a controlled underactuated mechanical system in which the dimensions of the configuration space exceed the dimensions of the control input space. The objectives of the research are to develop a novel SAMS model which is called beam-cart-seesaw system, and renovate a novel approach for achieving a high performance active-passive piezoelectric vibration absorber for such system. The system consists of two mobile carts, which are coupled via rack and pinion mechanics to two parallel tracks mounted on pneumatic rodless cylinders. One cart carries an elastic beam, and the other cart acts as a counterbalance. One adjustable counterweight mass is also installed underneath the seesaw to serve as a passive damping mechanism to absorb impact and shock energy. The motion and control of a Bernoulli-Euler beam subjected to the modified cart/seesaw system are analyzed first. Moreover, gray relational grade is utilized to investigate the sensitivity of tuning the active proportional-integral-derivative (PID) controller to achieve desired vibration suppression performance. Consequently, it is shown that the active-passive vibration absorber can not only provide passive damping, but can also enhance the active action authority. The proposed software/hardware platform can also be profitable for the standardization of laboratory equipment, as well as for the development of entertainment tools.

  14. Videometric research on deformation measurement of large-scale wind turbine blades

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Utilization of wind energy is a promising way to generate power,and wind turbine blades play a key role in collecting the wind energy effectively.This paper attempts to measure the deformation parameter of wind turbine blades in mechanics experiments using a videometric method. In view that the blades experience small buckling deformation and large integral deformation simultaneously, we proposed a parallel network measurement(PNM) method including the key techniques such as camera network construction,c...

  15. A New Processing Method Combined with BP Neural Network for Francis Turbine Synthetic Characteristic Curve Research

    Directory of Open Access Journals (Sweden)

    Junyi Li

    2017-01-01

    Full Text Available A BP (backpropagation neural network method is employed to solve the problems existing in the synthetic characteristic curve processing of hydroturbine at present that most studies are only concerned with data in the high efficiency and large guide vane opening area, which can hardly meet the research requirements of transition process especially in large fluctuation situation. The principle of the proposed method is to convert the nonlinear characteristics of turbine to torque and flow characteristics, which can be used for real-time simulation directly based on neural network. Results show that obtained sample data can be extended successfully to cover working areas wider under different operation conditions. Another major contribution of this paper is the resampling technique proposed in the paper to overcome the limitation to sample period simulation. In addition, a detailed analysis for improvements of iteration convergence of the pressure loop is proposed, leading to a better iterative convergence during the head pressure calculation. Actual applications verify that methods proposed in this paper have better simulation results which are closer to the field and provide a new perspective for hydroturbine synthetic characteristic curve fitting and modeling.

  16. Hurdles of CAR-T cell-based cancer immunotherapy directed against solid tumors.

    Science.gov (United States)

    Zhang, Bing-Lan; Qin, Di-Yuan; Mo, Ze-Ming; Li, Yi; Wei, Wei; Wang, Yong-Sheng; Wang, Wei; Wei, Yu-Quan

    2016-04-01

    Recent reports on the impressive efficacy of chimeric antigen receptor (CAR)-modified T cells against hematologic malignancies have inspired oncologists to extend these efforts for the treatment of solid tumors. Clinical trials of CAR-T-based cancer immunotherapy for solid tumors showed that the efficacies are not as remarkable as in the case of hematologic malignancies. There are several challenges that researchers must face when treating solid cancers with CAR-T cells, these include choosing an ideal target, promoting efficient trafficking and infiltration, overcoming the immunosuppressive microenvironment, and avoiding associated toxicity. In this review, we discuss the obstacles imposed by solid tumors on CAR-T cell-based immunotherapy and strategies adopted to improve the therapeutic potential of this approach. Continued investigations are necessary to improve therapeutic outcomes and decrease the adverse effects of CAR-T cell therapy in patients with solid malignancies in the future.

  17. New Approaches in CAR-T Cell Immunotherapy for Breast Cancer.

    Science.gov (United States)

    Wang, Jinghua; Zhou, Penghui

    2017-01-01

    Despite significant advances in surgery, chemotherapy, radiotherapy, endocrine therapy, and molecular-targeted therapy, breast cancer remains the leading cause of death from malignant tumors among women. Immunotherapy has recently become a critical component of breast cancer treatment with encouraging activity and mild safety profiles. CAR-T therapy using genetically modifying T cells with chimeric antigen receptors (CAR) is the most commonly used approach to generate tumor-specific T cells. It has shown good curative effect for a variety of malignant diseases, especially for hematological malignancies. In this review, we briefly introduce the history and the present state of CAR research. Then we discuss the barriers of solid tumors for CARs application and possible strategies to improve therapeutic response with a focus on breast cancer. At last, we outlook the future directions of CAR-T therapy including managing toxicities and developing universal CAR-T cells.

  18. The use of ZIP and CART to model cryptosporidiosis in relation to climatic variables.

    Science.gov (United States)

    Hu, Wenbiao; Mengersen, Kerrie; Fu, Shiu-Yun; Tong, Shilu

    2010-07-01

    This research assesses the potential impact of weekly weather variability on the incidence of cryptosporidiosis disease using time series zero-inflated Poisson (ZIP) and classification and regression tree (CART) models. Data on weather variables, notified cryptosporidiosis cases and population size in Brisbane were supplied by the Australian Bureau of Meteorology, Queensland Department of Health, and Australian Bureau of Statistics, respectively. Both time series ZIP and CART models show a clear association between weather variables (maximum temperature, relative humidity, rainfall and wind speed) and cryptosporidiosis disease. The time series CART models indicated that, when weekly maximum temperature exceeded 31 degrees C and relative humidity was less than 63%, the relative risk of cryptosporidiosis rose by 13.64 (expected morbidity: 39.4; 95% confidence interval: 30.9-47.9). These findings may have applications as a decision support tool in planning disease control and risk-management programs for cryptosporidiosis disease.

  19. Research on automatic inspection technique of real-time radiography for turbine-blade

    International Nuclear Information System (INIS)

    Zhou, Z.G.; Zhao, S.; An, Z.G.

    2004-01-01

    To inspect turbine blade automatically, with a real-time radiographic system based on X-ray flat panel detector, computerized defect extraction technique is studied on the basis of characteristics of turbine blade's digital radiographic images. At first, in the light of a variety of gray-level in a turbine blade's digital radiographic image, it is divided into six subareas. An adaptive median filter is used to smooth defects in each subarea. Then, the filtrated image is subtracted from the raw image and a difference image with flat background and outstanding defects is obtained. After that, thresholding is applied to the difference image and defects in the turbine blade become obvious. Later on, a morphological opening is used to realize noise reduction. In order to ensure the accuracy of defects, a region growing method is adopted to reconstruct the defects. Finally, the feature data of defects are extracted. The comparison between computerized feature extraction results and human interpretation results indicates that the method mentioned above is effective and efficient, which will lay a good foundation for automatic inspection of turbine-blade with X-ray. (author)

  20. Lewis Research Center studies of multiple large wind turbine generators on a utility network

    Science.gov (United States)

    Gilbert, L. J.; Triezenberg, D. M.

    1979-01-01

    A NASA-Lewis program to study the anticipated performance of a wind turbine generator farm on an electric utility network is surveyed. The paper describes the approach of the Lewis Wind Energy Project Office to developing analysis capabilities in the area of wind turbine generator-utility network computer simulations. Attention is given to areas such as, the Lewis Purdue hybrid simulation, an independent stability study, DOE multiunit plant study, and the WEST simulator. Also covered are the Lewis mod-2 simulation including analog simulation of a two wind turbine system and comparison with Boeing simulation results, and gust response of a two machine model. Finally future work to be done is noted and it is concluded that the study shows little interaction between the generators and between the generators and the bus.

  1. Turbinate surgery

    Science.gov (United States)

    Turbinectomy; Turbinoplasty; Turbinate reduction; Nasal airway surgery; Nasal obstruction - turbinate surgery ... There are several types of turbinate surgery: Turbinectomy: All or ... This can be done in several different ways, but sometimes a ...

  2. Research on the cavitation characteristic of Kaplan turbine under sediment flow condition

    International Nuclear Information System (INIS)

    Weili, L; Jinling, L; Xingqi, L; Yuan, L

    2010-01-01

    The sediment concentration in many rivers in our world is very high, and the Kaplan turbine running in these rivers are usually seriously abraded. Since the existence of sand, the probability of cavitation is greatly enhanced. Under the joint action and mutual promotion of cavitation and sand erosion, serious abrasion could be made, the hydraulic performance of the Kaplan turbine may be descended, and the safety and stability of turbine are greatly threatened. Therefore, it is very important and significant to investigate the cavitation characteristic of Kaplan turbine under sediment flow condition. In this paper, numerical simulation of cavitation characteristic in pure water and solid-liquid two-phase flow in Kaplan turbine was performed. The solid-liquid two-fluid model were adopted in the numerical simulation, and the pressure, velocity and particle concentration distributive regularity on turbine blade surface under different diameter and concentration was revealed. Particle trajectory model was used to investigate the region and degree of runner blade abrasion in different conditions. The results showed that serious sand abrasion could be found near the blade head and outlet in large flow rate working condition. Relatively slight abrasion may be found near blade flange in small flow rate working condition. The more the sediment concentration and the large the sand diameter, the serious the runner is abraded, and the greater the efficiency is decreased. further analysis of the combined effects of wear and abrasion was performed. The result shows that the cavitation in silt flow is more serious than in pure water. The runner cavitation performance become worse under high sand concentration and large particle diameter, and the efficiency decrease greatly with the increase of sediment concentration.

  3. Research on the cavitation characteristic of Kaplan turbine under sediment flow condition

    Energy Technology Data Exchange (ETDEWEB)

    Weili, L; Jinling, L; Xingqi, L; Yuan, L, E-mail: liaoweili2004@163.co [Institute of Water Resources and Hydro-Electric Engineering, Xi' an University of Technology No.5 South Jinhua Road, Xi' an, Shaanxi, 710048 (China)

    2010-08-15

    The sediment concentration in many rivers in our world is very high, and the Kaplan turbine running in these rivers are usually seriously abraded. Since the existence of sand, the probability of cavitation is greatly enhanced. Under the joint action and mutual promotion of cavitation and sand erosion, serious abrasion could be made, the hydraulic performance of the Kaplan turbine may be descended, and the safety and stability of turbine are greatly threatened. Therefore, it is very important and significant to investigate the cavitation characteristic of Kaplan turbine under sediment flow condition. In this paper, numerical simulation of cavitation characteristic in pure water and solid-liquid two-phase flow in Kaplan turbine was performed. The solid-liquid two-fluid model were adopted in the numerical simulation, and the pressure, velocity and particle concentration distributive regularity on turbine blade surface under different diameter and concentration was revealed. Particle trajectory model was used to investigate the region and degree of runner blade abrasion in different conditions. The results showed that serious sand abrasion could be found near the blade head and outlet in large flow rate working condition. Relatively slight abrasion may be found near blade flange in small flow rate working condition. The more the sediment concentration and the large the sand diameter, the serious the runner is abraded, and the greater the efficiency is decreased. further analysis of the combined effects of wear and abrasion was performed. The result shows that the cavitation in silt flow is more serious than in pure water. The runner cavitation performance become worse under high sand concentration and large particle diameter, and the efficiency decrease greatly with the increase of sediment concentration.

  4. Research on the cavitation characteristic of Kaplan turbine under sediment flow condition

    Science.gov (United States)

    Weili, L.; Jinling, L.; Xingqi, L.; Yuan, L.

    2010-08-01

    The sediment concentration in many rivers in our world is very high, and the Kaplan turbine running in these rivers are usually seriously abraded. Since the existence of sand, the probability of cavitation is greatly enhanced. Under the joint action and mutual promotion of cavitation and sand erosion, serious abrasion could be made, the hydraulic performance of the Kaplan turbine may be descended, and the safety and stability of turbine are greatly threatened. Therefore, it is very important and significant to investigate the cavitation characteristic of Kaplan turbine under sediment flow condition. In this paper, numerical simulation of cavitation characteristic in pure water and solid-liquid two-phase flow in Kaplan turbine was performed. The solid-liquid two-fluid model were adopted in the numerical simulation, and the pressure, velocity and particle concentration distributive regularity on turbine blade surface under different diameter and concentration was revealed. Particle trajectory model was used to investigate the region and degree of runner blade abrasion in different conditions. The results showed that serious sand abrasion could be found near the blade head and outlet in large flow rate working condition. Relatively slight abrasion may be found near blade flange in small flow rate working condition. The more the sediment concentration and the large the sand diameter, the serious the runner is abraded, and the greater the efficiency is decreased. further analysis of the combined effects of wear and abrasion was performed. The result shows that the cavitation in silt flow is more serious than in pure water. The runner cavitation performance become worse under high sand concentration and large particle diameter, and the efficiency decrease greatly with the increase of sediment concentration.

  5. Structure-activity relationship of CART (cocaine- and amphetamine-regulated transcript) peptide fragments

    Czech Academy of Sciences Publication Activity Database

    Maixnerová, Jana; Hlaváček, Jan; Blokešová, Darja; Kowalczyk, W.; Elbert, Tomáš; Šanda, Miloslav; Blechová, Miroslava; Železná, Blanka; Slaninová, Jiřina; Maletínská, Lenka

    2007-01-01

    Roč. 28, č. 10 (2007), s. 1945-1953 ISSN 0196-9781 R&D Projects: GA ČR GA303/05/0614 Institutional research plan: CEZ:AV0Z40550506 Keywords : CART peptide * fragments * binding * PC12 cells Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 2.368, year: 2007

  6. FY 1992 Report on results of the survey/research project commissioned by Sunshine Project. Surveys on hydrogen-fired turbines; 1992 nendo suiso nensho turbine no chosa seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-03-01

    Summarized herein are results of comprehensive surveys on hydrogen energy supply/utilization systems, centered by hydrogen-fired turbines for power generation. The surveyed items include hydrogen energy supply/utilization systems on an international scale, current state of power generation techniques and utilization of hydrogen, hydrogen-fired turbines for power generation, materials techniques for hydrogen-fired turbines, studies on and evaluation of economic viability of each system, expected effects, and problems involved in development. The surveys on the hydrogen production techniques pick up electrolysis with a solid polymer electrolyte as a promising candidate, and extract the scaling-up techniques, improvement of membrane durability, etc. as the research themes. The surveys on the hydrogen storage/transportation techniques indicate that hydrogen can be carried by a chemical medium for transportation/storage at normal temperature and pressure, for which the problems associated with medium loss and safety must be studied, and that the research themes for hydrogen-occluding alloys should include increasing quantities of hydrogen occluded for bulk transportation/storage at low energy, and decreasing cost. The surveys on hydrogen-fired turbines extract a number of problems to be solved, e.g., controlling hydrogen combustion, turbine designs, materials withstanding superhigh temperature for high-temperature combustion of hydrogen, and optimization of the power generation systems. (NEDO)

  7. Assessing the HIV Care Continuum in Latin America: progress in clinical retention, cART use and viral suppression

    Science.gov (United States)

    Rebeiro, Peter F; Cesar, Carina; Shepherd, Bryan E; De Boni, Raquel B; Cortés, Claudia P; Rodriguez, Fernanda; Belaunzarán-Zamudio, Pablo; Pape, Jean W; Padgett, Denis; Hoces, Daniel; McGowan, Catherine C; Cahn, Pedro

    2016-01-01

    Introduction We assessed trends in HIV Care Continuum outcomes associated with delayed disease progression and reduced transmission within a large Latin American cohort over a decade: clinical retention, combination antiretroviral therapy (cART) use and viral suppression (VS). Methods Adults from Caribbean, Central and South America network for HIV epidemiology clinical cohorts in seven countries contributed data between 2003 and 2012. Retention was defined as two or more HIV care visits annually, >90 days apart. cART was defined as prescription of three or more antiretroviral agents annually. VS was defined as HIV-1 RNA <200 copies/mL at last measurement annually. cART and VS denominators were subjects with at least one visit annually. Multivariable modified Poisson regression was used to assess temporal trends and examine associations between age, sex, HIV transmission mode, cohort, calendar year and time in care. Results Among 18,799 individuals in retention analyses, 14,380 in cART analyses and 13,330 in VS analyses, differences existed between those meeting indicator definitions versus those not by most characteristics. Retention, cART and VS significantly improved from 2003 to 2012 (63 to 77%, 74 to 91% and 53 to 82%, respectively; p<0.05, each). Female sex (risk ratio (RR)=0.97 vs. males) and injection drug use as HIV transmission mode (RR=0.83 vs. male sexual contact with males (MSM)) were significantly associated with lower retention, but unrelated with cART or VS. MSM (RR=0.96) significantly decreased the probability of cART compared with heterosexual transmission. Conclusions HIV Care Continuum outcomes improved over time in Latin America, though disparities for vulnerable groups remain. Efforts must be made to increase retention, cART and VS, while engaging in additional research to sustain progress in these settings. PMID:27065108

  8. FY 1993 Research and development of advanced ceramic gas turbines. Researches on social adaptability; 1993 nendo senshingata ceramic gas turbine no kenkyu kaihatsu seika hokokusho. Shakai tekigosei kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-05-01

    The ceramic gas turbines (CGT's) for, e.g., cogeneration and portable power generation systems are studied and evaluated for their environmental preservation, energy saving and economic characteristics. Types of utilization and market sizes are also studied for, e.g., portable power generation systems. The items studied include current status of cogeneration systems in USA, and recognition of cogeneration systems in Japan. The study results lead to the conclusions that the biaxial CGT for portable power generation systems is a promising substitute for diesel engines as the power source in the future, and 300kW class CGT's will have the markets of 170,000 units and potentially 450,000 units, because of their expected wide applicability. The studies on their economic, energy-saving and environmental load reduction effects indicate that one unit brings the economic effects totaling 616,000 yen, due to reduced fuel consumption and NOx abatement. They could reduce NOx emissions by 8,090 t/y for automobiles and 6,570 t/y for the others, when they fill the potential markets. (NEDO)

  9. Using CART to segment road images

    Science.gov (United States)

    Davies, Bob; Lienhart, Rainer

    2006-01-01

    The 2005 DARPA Grand Challenge is a 132 mile race through the desert with autonomous robotic vehicles. Lasers mounted on the car roof provide a map of the road up to 20 meters ahead of the car but the car needs to see further in order to go fast enough to win the race. Computer vision can extend that map of the road ahead but desert road is notoriously similar to the surrounding desert. The CART algorithm (Classification and Regression Trees) provided a machine learning boost to find road while at the same time measuring when that road could not be distinguished from surrounding desert.

  10. La carte scolaire et son assouplissement

    OpenAIRE

    Merle, Pierre

    2014-01-01

    Cet article a pour objet l'étude de la politique d’assouplissement de la carte scolaire mise en œuvre à partir de la rentrée scolaire 2007. Cette politique poursuit officiellement deux objectifs : apporter une plus grande liberté de choix de l’établissement aux parents ; favoriser la mixité sociale. L’étude de cette politique repose, dans un premier temps, sur l’analyse de la réalisation formelle des objectifs poursuivis (notamment la comparaison des anciens et nouveaux critères de dérogation...

  11. Resonance treatment methodology in DeCART

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kang Seog; Joo, Han Gyu; Lee, Chung Chan; Chang, Moon Hee

    2003-12-01

    The typical nuclear design procedure consists of two steps which are the transport lattice calculation for the fuel assembly and the nodal diffusion calculation for the reactor core. DeCART (Deterministic Core Analysis based on Ray Tracing) code has been developed to perform the 3-dimensional whole-core transport calculation removing some of the approximations in the 2-step procedure. This code employs the synthesis of 1- and 2-dimensional characteristics methods in the framework of the 3-dimensional CMFD (Coarse Mesh Finite Difference) formulation. The subgroup method is used for the resonance treatment. HELIOS library is used for the multi-group neutron cross section and the resonance data without any modification. This report includes the methodology of the resonance treatment in DeCART. And this report also includes the Monte Carlo resonance treatment under development for the generation of the resonance integral table and the subgroup data. The interpolation method of the equivalence cross section is reviewed for the efficient resonance transport calculation with thermal-hydraulic feedback, and the new method to consider the temperature distribution explicitly in the subgroup method is also introduced.

  12. Design of a microprocessor-based Control, Interface and Monitoring (CIM unit for turbine engine controls research

    Science.gov (United States)

    Delaat, J. C.; Soeder, J. F.

    1983-01-01

    High speed minicomputers were used in the past to implement advanced digital control algorithms for turbine engines. These minicomputers are typically large and expensive. It is desirable for a number of reasons to use microprocessor-based systems for future controls research. They are relatively compact, inexpensive, and are representative of the hardware that would be used for actual engine-mounted controls. The Control, Interface, and Monitoring Unit (CIM) contains a microprocessor-based controls computer, necessary interface hardware and a system to monitor while it is running an engine. It is presently being used to evaluate an advanced turbofan engine control algorithm.

  13. The use of wind data with an operational wind turbine in a research and development environment

    Science.gov (United States)

    Neustadter, H. E.

    1979-01-01

    It is noted that in 1976, 17 candidate sites were identified for detailed evaluation as potential sites for installation of large, horizontal axis Wind Turbines (WT). Attention is given to the Mod-OA, a 200 kW WT located in Clayton, New Mexico. The discussion covers the meteorological data collected, some of the analyses based on these wind data as well as additional areas currently being investigated in relation to these data.

  14. Numerical Research on Flow Characteristics around a Hydraulic Turbine Runner at Small Opening of Cylindrical Valve

    Directory of Open Access Journals (Sweden)

    Zhenwei Mo

    2016-01-01

    Full Text Available We use the continuity equation and the Reynolds averaged Navier-Stokes equations to study the flow-pattern characteristics around a turbine runner for the small-opening cylindrical valve of a hydraulic turbine. For closure, we adopt the renormalization-group k-ε two-equation turbulence model and use the computational fluid dynamics (CFD software FLUENT to numerically simulate the three-dimensional unsteady turbulent flow through the entire passage of the hydraulic turbine. The results show that a low-pressure zone develops around the runner blades when the cylindrical valve is closed in a small opening; cavitation occurs at the blades, and a vortex appears at the outlet of the runner. As the cylindrical valve is gradually closed, the flow velocity over the runner area increases, and the pressure gradient becomes more significant as the discharge decreases. In addition, the fluid flow velocity is relatively high between the lower end of the cylindrical valve and the base, so that a high-velocity jet is easily induced. The calculation and analysis provide a theoretical basis for improving the performance of cylindrical-valve operating systems.

  15. Wind Turbine Pitch Control and Load Mitigation Using an L1 Adaptive Approach

    Directory of Open Access Journals (Sweden)

    Danyong Li

    2014-01-01

    Full Text Available We present an application of L1 adaptive output feedback control design to wind turbine collective pitch control and load mitigation. Our main objective is the design of an L1 output feedback controller without wind speed estimation, ensuring that the generator speed tracks the reference trajectory with robustness to uncertain parameters and time-varying disturbances (mainly the uniform wind disturbance across the wind turbine rotor. The wind turbine model CART (controls advanced research turbine developed by the national renewable energy laboratory (NREL is used to validate the performance of the proposed L1 adaptive controller using the FAST (fatigue, aerodynamics, structures, and turbulence code. A comparative study is also conducted between the proposed controller and the most popular methods in practice: gain scheduling PI (GSPI controls and disturbance accommodating control (DAC methods. The results show better performance of L1 output feedback controller over the other two methods. Moreover, based on the FAST software and LQR analysis in the reference model selection of L1 adaptive controller, tradeoff can be achieved between control performance and loads mitigation.

  16. Professor: A motorized field-based phenotyping cart

    Science.gov (United States)

    An easy-to-customize, low-cost, low disturbance, motorized proximal sensing cart for field-based high-throughput phenotyping is described. General dimensions, motor specifications, and a remote operation application are given. The cart, named Professor, supports mounting multiple proximal sensors an...

  17. The Retarding Force on a Fan-Cart Reversing Direction

    Science.gov (United States)

    Aurora, Tarlok S.; Brunner, Bernard J.

    2011-01-01

    In introductory physics, students learn that an object tossed upward has a constant downward acceleration while going up, at the highest point and while falling down. To demonstrate this concept, a self-propelled fan cart system is used on a frictionless track. A quick push is given to the fan cart and it is allowed to move away on a track under…

  18. Shoulder joint loading and posture during medicine cart pushing task.

    Science.gov (United States)

    Xu, Xu; Lin, Jia-Hua; Boyer, Jon

    2013-01-01

    Excessive physical loads and awkward shoulder postures during pushing and pulling are risk factors for shoulder pain. Pushing a medicine cart is a major component of a work shift for nurses and medical assistants in hospitals and other health care facilities. A laboratory experiment was conducted to examine the effects of common factors (e.g., lane congestion, cart load stability, floor surface friction) on shoulder joint moment and shoulder elevation angle of participants during cart pushing. Participants pushed a medicine cart on straight tracks and turning around right-angle corners. Peak shoulder joint moments reached 25.1 Nm, 20.3 Nm, and 26.8 Nm for initial, transition, and turning phases of the pushing tasks, indicating that shoulder joint loading while pushing a medical cart is comparable to levels previously reported from heavy manual activities encountered in industry (e.g., garbage collection). Also, except for user experience, all other main study factors, including congestion level, cart load stability, location of transition strip, shoulder tendency, surface friction, and handedness, significantly influenced shoulder joint moment and shoulder elevation angle. The findings provide a better understanding of shoulder exposures associated with medicine cart operations and may be helpful in designing and optimizing the physical environment where medicine carts are used.

  19. Biomarkers of cytokine release syndrome and neurotoxicity related to CAR-T cell therapy.

    Science.gov (United States)

    Wang, Zhenguang; Han, Weidong

    2018-01-01

    Severe cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T cell (CAR-T) therapy can be life-threatening in some cases, and management of those toxicities is still a great challenge for physicians. Researchers hope to understand the pathophysiology of CRS and neurotoxicity, and identify predictive biomarkers that can forecast those toxicities in advance. Some risk factors for severe CRS and/or neurotoxicity including patient and treatment characteristics have been identified in multiple clinical trials of CAR-T cell therapy. Moreover, several groups have identified some predictive biomarkers that are able to determine beforehand which patients may suffer severe CRS and/or neurotoxicity during CAR-T cell therapy, facilitating testing of early intervention strategies for those toxicities. However, further studies are needed to better understand the biology and related risk factors for CRS and/or neurotoxicity, and determine if those identified predictors can be extrapolated to other series. Herein, we review the pathophysiology of CRS and neurotoxicity, and summarize the progress of predictive biomarkers to improve CAR-T cell therapy in cancer.

  20. KLASIFIKASI KARAKTERISTIK KECELAKAAN LALU LINTAS DI KOTA DENPASAR DENGAN PENDEKATAN CLASSIFICATION AND REGRESSION TREES (CART

    Directory of Open Access Journals (Sweden)

    I GEDE AGUS JIWADIANA

    2015-11-01

    Full Text Available The aim of this research is to determine the classification characteristics of traffic accidents in Denpasar city in January-July 2014 by using Classification And Regression Trees (CART. Then, for determine the explanatory variables into the main classifier of CART. The result showed that optimum CART generate three terminal node. First terminal node, there are 12 people were classified as heavy traffic accident characteritics with single accident, and second terminal nodes, there are 68 people were classified as minor traffic accident characteristics by type of traffic accident front-rear, front-front, front-side, pedestrians, side-side and location of traffic accident in district road and sub-district road. For third terminal node, there are 291 people were classified as medium traffic accident characteristics by type of traffic accident front-rear, front-front, front-side, pedestrians, side-side and location of traffic accident in municipality road and explanatory variables into the main splitter to make of CART is type of traffic accident with maximum homogeneity measure of 0.03252.

  1. Wind turbine control and monitoring

    CERN Document Server

    Luo, Ningsu; Acho, Leonardo

    2014-01-01

    Maximizing reader insights into the latest technical developments and trends involving wind turbine control and monitoring, fault diagnosis, and wind power systems, 'Wind Turbine Control and Monitoring' presents an accessible and straightforward introduction to wind turbines, but also includes an in-depth analysis incorporating illustrations, tables and examples on how to use wind turbine modeling and simulation software.   Featuring analysis from leading experts and researchers in the field, the book provides new understanding, methodologies and algorithms of control and monitoring, comput

  2. Establishing guidelines for CAR-T cells: challenges and considerations.

    Science.gov (United States)

    Wang, Wei; Qin, Di-Yuan; Zhang, Bing-Lan; Wei, Wei; Wang, Yong-Sheng; Wei, Yu-Quan

    2016-04-01

    T cells, genetically modified by chimeric antigen receptors (CAR-T), are endowed with specificity to a desired antigen and are cytotoxic to cells expressing the targeted antigen. CAR-T-based cancer immunotherapy is a promising therapy for curing hematological malignancy, such as acute lymphoid leukemia, and is promising for extending their efficacy to defeat solid tumors. To date, dozens of different CAR-T cells have been evaluated in clinical trials to treat tumors; this necessitates the establishment of guidelines for the production and application of CAR-T cells. However, it is challenging to standardize CAR-T cancer therapy because it involves a combination of gene therapy and cell therapy. In this review, we compare the existing guidelines for CAR-T cells and discuss the challenges and considerations for establishing guidance for CAR-T-based cancer immunotherapy.

  3. Involvement of CART in estradiol-induced anorexia.

    Science.gov (United States)

    Dandekar, Manoj P; Nakhate, Kartik T; Kokare, Dadasaheb M; Subhedar, Nishikant K

    2012-01-18

    Since estradiol exercises inhibitory effect on food intake, we wanted to find out if this influence of estradiol is mediated by cocaine- and amphetamine-regulated transcript peptide (CART), a well established anorectic agent in the brain. Ovariectomized (OVX) rats, replaced with estradiol to produce estrous-phase like conditions, showed a significant decrease in food intake as compared with that in OVX controls. Intracerebroventricular (icv) administration of CART (0.5-1 μg/rat) to OVX rats, resulted in a dose-dependent reduction in the food intake. The lower dose (0.25 μg) had no effect, and was considered subeffective. In estradiol replaced OVX rats, CART at subeffective dose, further reduced food intake. However, CART failed to reduce food intake in estradiol replaced OVX rats pretreated with anti-estrogenic agent tamoxifen (3 mg/kg, subcutaneous). Administration of CART antibody (1:500 dilution/rat, i.c.v.) significantly attenuated estradiol-induced anorexia in the OVX rats. While estradiol replacement significantly increased CART-immunoreactivity in the cells/fibers of paraventricular nucleus (PVN) of OVX rats, fibers in the anteroventral periventricular nucleus (AVPV), and cells/fibers in the arcuate nucleus (ARC) showed considerable reduction. These changes were attenuated following concurrent injection of tamoxifen to the estradiol replaced OVX rats. However, CART-immunoreactive cells/fibers in the periventricular area did not respond to any of the treatments. We suggest that estradiol treatment might influence the hypothalamic CART system in a site specific manner. While increased CART activity in the PVN might produce anorexia, reduction of CART in ARC and AVPV might represent a compensatory homeostatic response. Copyright © 2011 Elsevier Inc. All rights reserved.

  4. Evaluation of the New York City Green Carts program

    Directory of Open Access Journals (Sweden)

    Shannon M Farley

    2015-12-01

    Full Text Available Access to fresh fruits and vegetables is a concern, particularly among low-income populations. Mobile vending is one strategy to expand produce availability and access to increase consumption. In 2008, New York City launched a mobile vending initiative, Green Carts. We report on the evaluation. Three waves of cross-sectional observational surveys of produce availability, variety, and quality were conducted during the summers of 2008, 2009, and 2011 in a stratified random sample of stores and carts comparing establishments in Green Cart neighborhoods (n = 13 with comparison neighborhoods (n = 3. Bivariate analyses for availability, variety, and quality comparing Green Cart and comparison neighborhoods were presented across years, and logistic and negative binomial regressions were used to test whether fruit and vegetable availability, variety, and quality increased in Green Cart compared with comparison neighborhoods, adjusting for clustering and neighborhood demographics. Establishments selling fruits and vegetables in Green Cart neighborhoods increased between 2008 and 2011 (50% to 69%, p <0.0001; there was no comparable increase in comparison neighborhoods. Establishments selling more than 10 fruits and vegetables types increased from 31% to 38% (p = 0.0414 in Green Cart neighborhoods; there was no change in comparison neighborhoods. Produce quality was high among comparison establishments, with 95% and 94% meeting the quality threshold in 2008 and 2011, while declining in Green Cart neighborhood establishments from 96% to 88% (p < 0.0001. Sustained produce availability was found in Green Cart neighborhoods between 2008–2011. Green Carts are one strategy contributing to improving produce access among New Yorkers.

  5. Refinements and Tests of an Advanced Controller to Mitigate Fatigue Loads in the Controls Advanced Research Turbine

    NARCIS (Netherlands)

    Wright, A.D.; Fleming, P.; Van Wingerden, J.W.

    2011-01-01

    Wind turbines are complex, nonlinear, dynamic systems forced by aerodynamic, gravitational, centrifugal, and gyroscopic loads. The aerodynamics of wind turbines are nonlinear, unsteady, and complex. Turbine rotors are subjected to a complicated 3-D turbulent wind inflow field, with imbedded coherent

  6. Research on Model-Based Fault Diagnosis for a Gas Turbine Based on Transient Performance

    Directory of Open Access Journals (Sweden)

    Detang Zeng

    2018-01-01

    Full Text Available It is essential to monitor and to diagnose faults in rotating machinery with a high thrust–weight ratio and complex structure for a variety of industrial applications, for which reliable signal measurements are required. However, the measured values consist of the true values of the parameters, the inertia of measurements, random errors and systematic errors. Such signals cannot reflect the true performance state and the health state of rotating machinery accurately. High-quality, steady-state measurements are necessary for most current diagnostic methods. Unfortunately, it is hard to obtain these kinds of measurements for most rotating machinery. Diagnosis based on transient performance is a useful tool that can potentially solve this problem. A model-based fault diagnosis method for gas turbines based on transient performance is proposed in this paper. The fault diagnosis consists of a dynamic simulation model, a diagnostic scheme, and an optimization algorithm. A high-accuracy, nonlinear, dynamic gas turbine model using a modular modeling method is presented that involves thermophysical properties, a component characteristic chart, and system inertial. The startup process is simulated using this model. The consistency between the simulation results and the field operation data shows the validity of the model and the advantages of transient accumulated deviation. In addition, a diagnostic scheme is designed to fulfill this process. Finally, cuckoo search is selected to solve the optimization problem in fault diagnosis. Comparative diagnostic results for a gas turbine before and after washing indicate the improved effectiveness and accuracy of the proposed method of using data from transient processes, compared with traditional methods using data from the steady state.

  7. Pendekatan Cart untuk Mendapatkan Faktor yang Mempengaruhi Terjangkitnya Penyakit Demam Tifoid di Aceh Utara

    Directory of Open Access Journals (Sweden)

    Dina Yuanita

    2010-05-01

    research conducted to find factors that influence the outbreak of typhoid fever in NAD. research using the CART Method. The results of the analysis indicate that the main factor causing typhoid fever was drinking water reservoirs. The other factors are waste water reservoirs, the physical quality of drinking water, a habit washing hands with soap before eating, the bowel, the dump, gender, socioeconomic status, habits of washing hands with soap after defecation and health education.

  8. La carte des 36 000 communes

    Directory of Open Access Journals (Sweden)

    Aliette DELAMARRE

    1989-12-01

    Full Text Available La carte généralisée du maillage communal français, obtenue à partir d'un sondage spatial au quart, met en évidence des modèles régionaux caractérisés par des mailles inégalement fines. Cette division du territoire, héritée de la trame paroissiale, a été mise en mémoire par la création, en 1789, de l'institution communale. Seuls les travaux de géographie historique permettront de découvrir les mécanismes de sa mise en place à dater des Xe-XIe, voire des VIe et VIIe siècles.

  9. Research on Francis Turbine Modeling for Large Disturbance Hydropower Station Transient Process Simulation

    Directory of Open Access Journals (Sweden)

    Guangtao Zhang

    2015-01-01

    Full Text Available In the field of hydropower station transient process simulation (HSTPS, characteristic graph-based iterative hydroturbine model (CGIHM has been widely used when large disturbance hydroturbine modeling is involved. However, by this model, iteration should be used to calculate speed and pressure, and slow convergence or no convergence problems may be encountered for some reasons like special characteristic graph profile, inappropriate iterative algorithm, or inappropriate interpolation algorithm, and so forth. Also, other conventional large disturbance hydroturbine models are of some disadvantages and difficult to be used widely in HSTPS. Therefore, to obtain an accurate simulation result, a simple method for hydroturbine modeling is proposed. By this method, both the initial operating point and the transfer coefficients of linear hydroturbine model keep changing during simulation. Hence, it can reflect the nonlinearity of the hydroturbine and be used for Francis turbine simulation under large disturbance condition. To validate the proposed method, both large disturbance and small disturbance simulations of a single hydrounit supplying a resistive, isolated load were conducted. It was shown that the simulation result is consistent with that of field test. Consequently, the proposed method is an attractive option for HSTPS involving Francis turbine modeling under large disturbance condition.

  10. Noise from wind turbines

    International Nuclear Information System (INIS)

    Andersen, B.; Larsen, P.

    1993-01-01

    Denmark has 3200 wind turbines with an installed maximum capacity of 418MW. The most important Danish research projects into wind turbine noise and the main results are listed. These date from 1983. Two comprehensive studies are currently in progress. The first is an analytical and empirical investigation of aerodynamic noise from wind turbine rotors and has so far dealt mainly with tip noise. The measurement method, using a hard board mounted microphone on the ground near the turbine, is described. Four different tip designs have been tested. Some examples of reference sound power level spectra for three of the designs are presented. During the past two years a computerbased data acquisition system has been used for real-time determination of sound power levels. The second study, which has just commenced, is on annoyance from wind turbine noise. It will include noise measurements, masking calculations and a social survey on the perceived nuisance. (UK)

  11. Graphene in turbine blades

    Science.gov (United States)

    Das, D. K.; Swain, P. K.; Sahoo, S.

    2016-07-01

    Graphene, the two-dimensional (2D) nanomaterial, draws interest of several researchers due to its many superior properties. It has extensive applications in numerous fields. A turbine is a hydraulic machine which extracts energy from a fluid and converts it into useful work. Recently, Gudukeya and Madanhire have tried to increase the efficiency of Pelton turbine. Beucher et al. have also tried the same by reducing friction between fluid and turbine blades. In this paper, we study the advantages of using graphene as a coating on Pelton turbine blades. It is found that the efficiency of turbines increases, running and maintenance cost is reduced with more power output. By the application of graphene in pipes, cavitation will be reduced, durability of pipes will increase, operation and maintenance cost of water power plants will be less.

  12. Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus-Driven Production of a Bispecific T-cell Engager.

    Science.gov (United States)

    Wing, Anna; Fajardo, Carlos Alberto; Posey, Avery D; Shaw, Carolyn; Da, Tong; Young, Regina M; Alemany, Ramon; June, Carl H; Guedan, Sonia

    2018-05-01

    T cells expressing chimeric antigen receptors (CART) have shown significant promise in clinical trials to treat hematologic malignancies, but their efficacy in solid tumors has been limited. Oncolytic viruses have the potential to act in synergy with immunotherapies due to their immunogenic oncolytic properties and the opportunity of incorporating therapeutic transgenes in their genomes. Here, we hypothesized that an oncolytic adenovirus armed with an EGFR-targeting, bispecific T-cell engager (OAd-BiTE) would improve the outcome of CART-cell therapy in solid tumors. We report that CART cells targeting the folate receptor alpha (FR-α) successfully infiltrated preestablished xenograft tumors but failed to induce complete responses, presumably due to the presence of antigen-negative cancer cells. We demonstrated that OAd-BiTE-mediated oncolysis significantly improved CART-cell activation and proliferation, while increasing cytokine production and cytotoxicity, and showed an in vitro favorable safety profile compared with EGFR-targeting CARTs. BiTEs secreted from infected cells redirected CART cells toward EGFR in the absence of FR-α, thereby addressing tumor heterogeneity. BiTE secretion also redirected CAR-negative, nonspecific T cells found in CART-cell preparations toward tumor cells. The combinatorial approach improved antitumor efficacy and prolonged survival in mouse models of cancer when compared with the monotherapies, and this was the result of an increased BiTE-mediated T-cell activation in tumors. Overall, these results demonstrated that the combination of a BiTE-expressing oncolytic virus with adoptive CART-cell therapy overcomes key limitations of CART cells and BiTEs as monotherapies in solid tumors and encourage its further evaluation in human trials. Cancer Immunol Res; 6(5); 605-16. ©2018 AACR . ©2018 American Association for Cancer Research.

  13. Potential health impact of wind turbines

    International Nuclear Information System (INIS)

    2010-05-01

    In response to public health concerns about wind turbines, a study was conducted to review the scientific evidence on the potential health effects of wind turbines. Several research questions were examined, including scientific evidence on the potential health impacts of wind turbines; the relationship between wind turbine noise and health; the relationship between low frequency sound, infrasound and health; assessment of exposure to wind turbines; wind turbine health and safety hazards and Ontario wind turbine setbacks; community consultation prior to wind farm construction and data gaps and research needs. The study showed that although some people living near wind turbines reported symptoms such as dizziness, headaches, and sleep disturbance, the scientific evidence available to date does not demonstrate a direct causal link between wind turbine noise and adverse health effects. The sound level from wind turbines at common residential setbacks is not sufficient to cause hearing impairment or other direct health effects, although some people may find it annoying. 41 refs., 1 appendix.

  14. Cocaine- and amphetamine-regulated transcript (CART) peptide specific binding in pheochromocytoma cells PC12

    Czech Academy of Sciences Publication Activity Database

    Maletínská, Lenka; Maixnerová, Jana; Matyšková, Resha; Haugvicová, Renata; Šloncová, Eva; Elbert, Tomáš; Slaninová, Jiřina; Železná, Blanka

    2007-01-01

    Roč. 559, 2/3 (2007), s. 109-114 ISSN 0014-2999 R&D Projects: GA ČR GA303/05/0614 Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520514; CEZ:AV0Z50200510 Keywords : radioligand binding * CART * PC12 cells * food intake Subject RIV: CE - Biochemistry Impact factor: 2.376, year: 2007

  15. CAR-T Cell Therapies From the Transfusion Medicine Perspective.

    Science.gov (United States)

    Fesnak, Andrew; Lin, ChieYu; Siegel, Don L; Maus, Marcela V

    2016-07-01

    The use of chimeric antigen receptor (CAR)-T cell therapy for the treatment of hematologic malignancies has generated significant excitement over the last several years. From a transfusion medicine perspective, the implementation of CAR-T therapy as a potential mainstay treatment for not only hematologic but also solid-organ malignancies represents a significant opportunity for growth and expansion. In this review, we will describe the rationale for the development of genetically redirected T cells as a cancer therapeutic, the different elements that are required to engineer these cells, as well as an overview of the process by which patient cells are harvested and processed to create and subsequently validate CAR-T cells. Finally, we will briefly describe some of the toxicities and clinical efficacy of CAR-T cells in the setting of patients with advanced malignancy. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Ejection of a rear facing, golf cart passenger.

    Science.gov (United States)

    Schau, Kyle; Masory, Oren

    2013-10-01

    The following report details the findings of a series of experiments and simulations performed on a commercially available, shuttle style golf cart during several maneuvers involving rapid accelerations of the vehicle. It is determined that the current set of passive restraints on these types of golf carts are not adequate in preventing ejection of a rear facing passenger during rapid accelerations in the forward and lateral directions. Experimental data and simulations show that a hip restraint must be a minimum of 13 in. above the seat in order to secure a rear facing passenger during sharp turns, compared to the current restraint height of 5 in. Furthermore, it is determined that a restraint directly in front of the rear facing passenger is necessary to prevent ejection. In addressing these issues, golf cart manufacturers could greatly reduce the likelihood of injury due to ejection of a rear facing, golf cart passenger. Copyright © 2013 Elsevier Ltd. All rights reserved.

  17. Gravo-Aeroelastic Scaling for Extreme-Scale Wind Turbines

    Energy Technology Data Exchange (ETDEWEB)

    Fingersh, Lee J [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Loth, Eric [University of Virginia; Kaminski, Meghan [University of Virginia; Qin, Chao [University of Virginia; Griffith, D. Todd [Sandia National Laboratories

    2017-06-09

    A scaling methodology is described in the present paper for extreme-scale wind turbines (rated at 10 MW or more) that allow their sub-scale turbines to capture their key blade dynamics and aeroelastic deflections. For extreme-scale turbines, such deflections and dynamics can be substantial and are primarily driven by centrifugal, thrust and gravity forces as well as the net torque. Each of these are in turn a function of various wind conditions, including turbulence levels that cause shear, veer, and gust loads. The 13.2 MW rated SNL100-03 rotor design, having a blade length of 100-meters, is herein scaled to the CART3 wind turbine at NREL using 25% geometric scaling and blade mass and wind speed scaled by gravo-aeroelastic constraints. In order to mimic the ultralight structure on the advanced concept extreme-scale design the scaling results indicate that the gravo-aeroelastically scaled blades for the CART3 are be three times lighter and 25% longer than the current CART3 blades. A benefit of this scaling approach is that the scaled wind speeds needed for testing are reduced (in this case by a factor of two), allowing testing under extreme gust conditions to be much more easily achieved. Most importantly, this scaling approach can investigate extreme-scale concepts including dynamic behaviors and aeroelastic deflections (including flutter) at an extremely small fraction of the full-scale cost.

  18. Design of an automated cart and mount for a hyperspectral imaging system to be used in produce fields

    Science.gov (United States)

    Lefcourt, Alan M.; Kistler, Ross; Gadsden, S. Andrew

    2016-05-01

    The goal of this project was to construct a cart and a mounting system that would allow a hyperspectral laser-induced fluorescence imaging system (HLIFIS) to be used to detect fecal material in produce fields. Fecal contaminated produce is a recognized food safety risk. Previous research demonstrated the HLIFIS could detect fecal contamination in a laboratory setting. A cart was designed and built, and then tested to demonstrate that the cart was capable of moving at constant speeds or at precise intervals. A mounting system was designed and built to facilitate the critical alignment of the camera's imaging and the laser's illumination fields, and to allow the HLIFIS to be used in both field and laboratory settings without changing alignments. A hardened mount for the Powell lens that is used to produce the appropriate illumination profile was also designed, built, and tested.

  19. Hydraulic turbines

    International Nuclear Information System (INIS)

    Meluk O, G.

    1998-01-01

    The hydraulic turbines are defined according to the specific speed, in impulse turbines and in reaction turbines. Currently, the Pelton turbines (of impulse) and the Francis and Kaplan turbines (of reaction), they are the most important machines in the hydroelectric generation. The hydraulic turbines are capable of generating in short times, large powers, from its loads zero until the total load and reject the load instantly without producing damages in the operation. When the hydraulic resources are important, the hydraulic turbines are converted in the axle of the electric system. Its combination with thermoelectric generation systems, it allow the continuing supply of the variations in demand of energy system. The available hydraulic resource in Colombia is of 93085 MW, of which solely 9% is exploited, become 79% of all the electrical country generation, 21% remaining is provided by means of the thermoelectric generation

  20. Clinical trials of CAR-T cells in China

    OpenAIRE

    Bingshan Liu; Yongping Song; Delong Liu

    2017-01-01

    Abstract Novel immunotherapeutic agents targeting tumor-site microenvironment are revolutionizing cancer therapy. Chimeric antigen receptor (CAR)-engineered T cells are widely studied for cancer immunotherapy. CD19-specific CAR-T cells, tisagenlecleucel, have been recently approved for clinical application. Ongoing clinical trials are testing CAR designs directed at novel targets involved in hematological and solid malignancies. In addition to trials of single-target CAR-T cells, simultaneous...

  1. La Carte de Localisation Probable des Avalanches (CPLA

    Directory of Open Access Journals (Sweden)

    Gilles BORREL

    1994-12-01

    Full Text Available La Carte de Localisation Probable des Avalanches (CPLA indique l’enveloppe des limites extrêmes connues atteintes par les avalanches, ainsi que les travaux de protection associés. Il s’agit d’un document informatif et non d’une carte de risque. Depuis 1990, les données thématiques sont numérisées.

  2. Analysis of technological innovation in Danish wind turbine industry - including the Test Station for Windturbines dual roll as research institution and certification authority

    International Nuclear Information System (INIS)

    Dannemand Andersen, P.

    1993-01-01

    The overall aim of this thesis is to examine the interactions between the Danish wind turbine industry and the Test Station for Wind Turbines. Because these interactions are concerning technological innovation, it follows that the innovation processes within the enterprises must be analyzed and modelled. The study is carried out as an iterative model-developing process using case study methods. The findings from some less structured interviews are discussed with literature and forms a basis for models and new interviews. The thesis is based on interviews with 20 R and D engineers in the Danish wind turbine industry, 7 engineers at The Test Station and 7 people involved in wind power abroad (American and British). The theoretical frame for this thesis is sociology/organizational theory and industrial engineering. The thesis consists of five main sections, dealing with technology and knowledge, innovation processes, organizational culture, innovation and interaction between the Test Station's research activities and the companies' innovation processes, and finally interaction through the Test Stations certification activity. First a taxonomy for technology and knowledge is established in order to clarify what kind of technology the interactions are all about, and what kind of knowledge is transferred during the interactions. This part of the thesis also contains an analysis of the patents drawn by the Danish wind turbine industry. The analysis shows that the Danish wind turbine industry do not use patents. Instead the nature of the technology and the speed of innovation are used to protect the industry's knowledge. (EG) (192 refs.)

  3. Research and engineering application of coordinated instrumentation control and protection technology between reactor and steam turbine generator on nuclear power plant

    International Nuclear Information System (INIS)

    Sun Xingdong

    2014-01-01

    The coordinated instrumentation control and protection technology between reactor and steam turbine generator (TG) usually is very significant and complicated for a new construction of nuclear power plant, because it carries the safety, economy and availability of nuclear power plant. Based on successful practice of a nuclear power plant, the experience on interface design and hardware architecture of coordinated instrumentation control and protection technology between reactor and steam turbine generator was abstracted and researched. In this paper, the key points and engineering experience were introduced to give the helpful instructions for the new project. (author)

  4. Maintenance for power conversion system of gas turbine high temperature reactor (GTHTR300). Contract research

    Energy Technology Data Exchange (ETDEWEB)

    Kosugiyama, Shinichi; Takada, Shoji; Katanishi, Shoji; Yan, Xing; Takizuka, Takakazu; Kunitomi, Kazuhiko [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment

    2002-11-01

    In order to be a suitable next generation nuclear power plant from reliable and economical points of view, it is necessary for GTHTR300 to have good maintenability and inspectability. Appropriate maintenance concept for the power conversion system of GTHTR300 consisting of a gas turbine, a compressor, a generator, a recuperator, a precooler and so on was studied based on results of the basic design of GTHTR300 in fiscal 2001. Considering degradation phenomena which could occur on each objective equipment, it is technically possible to reduce several maintenance items and extend maintenance interval for some equipment compared to those for existing LWR power plants and combined cycle fossil power plants. But owing to structural feature and installed location of each equipment, and fission product plate-out on each equipment, it became clear that some problems must be solved for making the maintenance works realistic and efficient. Solving the problems and confirming appropriateness of the proposed maintenance concept and plans will be done in coming detailing work of GTHTR300 design. (author)

  5. Final Technical Report: Supporting Wind Turbine Research and Testing - Gearbox Durability Study

    Energy Technology Data Exchange (ETDEWEB)

    Matthew Malkin

    2012-04-30

    The combination of premature failure of wind turbine gearboxes and the downtime caused by those failures leads to an increase in the cost of electricity produced by the wind. There is a need for guidance to asset managers regarding how to maximize the longevity of their gearboxes in order to help keep the cost of wind energy as low as possible. A low cost of energy supports the US Department of Energy's goal of achieving 20% of the electricity in the United States produced by wind by the year 2030. DNV KEMA has leveraged our unique position in the industry as an independent third party engineering organization to study the problem of gearbox health management and develop guidance to project operators. This report describes the study. The study was conducted in four tasks. In Task 1, data that may be related to gearbox health and are normally available to wind project operators were collected for analysis. Task 2 took a more in-depth look at a small number of gearboxes to gain insight in to relevant failure modes. Task 3 brought together the previous tasks by evaluating the available data in an effort to identify data that could provide early indications of impending gearbox failure. Last, the observations from the work were collected to develop recommendations regarding gearbox health management.

  6. Research on Automatic Positioning System of Ultrasonic Testing of Wind Turbine Blade Flaws

    Science.gov (United States)

    Liu, Q. X.; Wang, Z. H.; Long, S. G.; Cai, M.; Cai, M.; Wang, X.; Chen, X. Y.; Bu, J. L.

    2017-11-01

    Ultrasonic testing technology has been used essentially in non-destructive testing of wind turbine blades. However, it is fact that the ultrasonic flaw detection method has inefficiently employed in recent years. This is because the testing result will illustrate a small deviation due to the artificial, environmental and technical factors. Therefore, it is an urgent technical demand for engineers to test the various flaws efficiently and quickly. An automatic positioning system has been designed in this paper to record the moving coordinates and the target distance in real time. Simultaneously, it could launch and acquire the sonic wave automatically. The ADNS-3080 optoelectronic chip is manufactured by Agilent Technologies Inc, which is also utilized in the system. With the combination of the chip, the power conversion module and the USB transmission module, the collected data can be transmitted from the upper monitor to the hardware that could process and control the data through software programming. An experiment has been designed to prove the reliability of automotive positioning system. The result has been validated by comparing the result collected form LABVIEW and actual plots on Perspex plane, it concludes that the system possesses high accuracy and magnificent meanings in practical engineering.

  7. Paralleled comparison of vectors for the generation of CAR-T cells.

    Science.gov (United States)

    Qin, Di-Yuan; Huang, Yong; Li, Dan; Wang, Yong-Sheng; Wang, Wei; Wei, Yu-Quan

    2016-09-01

    T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches, several gene-transfer methods were used to deliver CARs or other genes into T-lymphocytes, equipping CAR-modified T cells with a property of recognizing and attacking antigen-expressing tumor cells in a major histocompatibility complex-independent manner. Here, we summarize the gene-transfer vectors commonly used in the generation of CAR-T cell, including retrovirus vectors, lentivirus vectors, the transposon/transposase system, the plasmid-based system, and the messenger RNA electroporation system. The following aspects were compared in parallel: efficiency of gene transfer, the integration methods in the modified T cells, foreground of scale-up production, and application and development in clinical trials. These aspects should be taken into account to generate the optimal CAR-gene vector that may be suitable for future clinical application.

  8. Feeding-related effects of cart (cocaine and amphetamine regulated transcript) peptides and cholecystokinin in mouse obese models

    Czech Academy of Sciences Publication Activity Database

    Maletínská, Lenka; Maixnerová, Jana; Toma, Resha Shamas; Haugvicová, Renata; Slaninová, Jiřina; Železná, Blanka

    2006-01-01

    Roč. 12, Supplement (2006), s. 178 ISSN 1075-2617. [European Peptide Symposium /29./. 03.09.2006-08.09.2006, Gdansk] Institutional research plan: CEZ:AV0Z40550506 Keywords : CART peptides * food intake * mouse obesity * CCK Subject RIV: CC - Organic Chemistry

  9. Structure-activity relationship of cocaine- and amphetamine-regulated transcript (CART) by peptide analogs: Importance of disulfide bridges

    Czech Academy of Sciences Publication Activity Database

    Blechová, Miroslava; Nagelová, Veronika; Demianova, Zuzana; Železná, Blanka; Maletínská, Lenka

    2012-01-01

    Roč. 18, S1 (2012), S89-S90 ISSN 1075-2617. [European Peptide Symposium /32./. 02.09.2012-07.09.2012, Athens] Institutional research plan: CEZ:AV0Z40550506 Keywords : CART * neuropeptides * cell line PC12 * anorexigenic effect Subject RIV: CE - Biochemistry

  10. Synergistic effect of CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin on food intake regulation in lean mice

    Czech Academy of Sciences Publication Activity Database

    Maletínská, Lenka; Maixnerová, Jana; Matyšková, Resha; Haugvicová, Renata; Pirnik, Z.; Kiss, A.; Železná, Blanka

    2008-01-01

    Roč. 9, č. 101 (2008), s. 1-10 ISSN 1471-2202 R&D Projects: GA ČR GA303/05/0614 Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50200510 Keywords : mice * food intake * CART peptide Subject RIV: CE - Biochemistry Impact factor: 2.850, year: 2008

  11. Study on the fuel cycle cost of gas turbine high temperature reactor (GTHTR300). Contract research

    Energy Technology Data Exchange (ETDEWEB)

    Takei, Masanobu; Katanishi, Shoji; Nakata, Tetsuo; Kunitomi, Kazuhiko [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment; Oda, Takefumi; Izumiya, Toru [Nuclear Fuel Industries, Ltd., Tokyo (Japan)

    2002-11-01

    In the basic design of gas turbine high temperature reactor (GTHTR300), reduction of the fuel cycle cost has a large benefit of improving overall plant economy. Then, fuel cycle cost was evaluated for GTHTR300. First, of fuel fabrication for high-temperature gas cooled reactor, since there was no actual experience with a commercial scale, a preliminary design for a fuel fabrication plant with annual processing of 7.7 ton-U sufficient four GTHTR300 was performed, and fuel fabrication cost was evaluated. Second, fuel cycle cost was evaluated based on the equilibrium cycle of GTHTR300. The factors which were considered in this cost evaluation include uranium price, conversion, enrichment, fabrication, storage of spent fuel, reprocessing, and waste disposal. The fuel cycle cost of GTHTR300 was estimated at about 1.07 yen/kWh. If the back-end cost of reprocessing and waste disposal is included and assumed to be nearly equivalent to LWR, the fuel cycle cost of GTHTR300 was estimated to be about 1.31 yen/kWh. Furthermore, the effects on fuel fabrication cost by such of fuel specification parameters as enrichment, the number of fuel types, and the layer thickness were considered. Even if the enrichment varies from 10 to 20%, the number of fuel types change from 1 to 4, the 1st layer thickness of fuel changes by 30 {mu}m, or the 2nd layer to the 4th layer thickness of fuel changes by 10 {mu}m, the impact on fuel fabrication cost was evaluated to be negligible. (author)

  12. Design of the CART data system for the US Department of Energy's ARM Program

    International Nuclear Information System (INIS)

    Melton, R.B.; Campbell, A.P.; Edwards, D.M.; Kanciruk, P.; Tichler, J.L.

    1991-01-01

    The Department of Energy (DOE) has initiated a major atmospheric research effort to reduce the uncertainties found in general circulation and other models due to the effects of clouds and radiation. The objective of the Atmospheric Radiation Measurement Program (ARM) is to provide an experimental testbed for the study of important atmospheric effects, particularly cloud and radiative processes, and testing parameterizations of the processes for use in atmospheric models. This experimental testbed, known as the Clouds and Radiation Testbed (CART), will include a complex data system, the CART Data Environment (CDE). The major functions of the CDE will be to: acquire environments from instruments and external data sources; perform quality assessments of the data streams; create data streams of known quality to be used as model input compared to model output; execute the models and capture their predictions; and make data streams associated with model tests available to ARM investigators in near real-time. The CDE will also be expected to capture ancillary information (''meta-data'') associated with the data streams, provide data management facilities for design of ARM experiments, and provide for archival data storage. The first section of this paper presents background information on CART. Next the process for the functional design of the system is described, the functional requirements summarized, and the conceptual architecture of the CDE is presented. Finally, the status of the CDE design activities is summarized, and major technical challenges are discussed

  13. CAR-T cell therapy in ovarian cancer: from the bench to the bedside.

    Science.gov (United States)

    Zhu, Xinxin; Cai, Han; Zhao, Ling; Ning, Li; Lang, Jinghe

    2017-09-08

    Ovarian cancer (OC) is the most lethal gynecological malignancy and is responsible for most gynecological cancer deaths. Apart from conventional surgery, chemotherapy, and radiotherapy, chimeric antigen receptor-modified T (CAR-T) cells as a representative of adoptive cellular immunotherapy have received considerable attention in the research field of cancer treatment. CARs combine antigen specificity and T-cell-activating properties in a single fusion molecule. Several preclinical experiments and clinical trials have confirmed that adoptive cell immunotherapy using typical CAR-engineered T cells for OC is a promising treatment approach with striking clinical efficacy; moreover, the emerging CAR-Ts targeting various antigens also exert great potential. However, such therapies have side effects and toxicities, such as cytokine-associated and "on-target, off-tumor" toxicities. In this review, we systematically detail and highlight the present knowledge of CAR-Ts including the constructions, vectors, clinical applications, development challenges, and solutions of CAR-T-cell therapy for OC. We hope to provide new insight into OC treatment for the future.

  14. Analysis of performance measures to handle medical E-commerce shopping cart abandonment in cloud

    Directory of Open Access Journals (Sweden)

    Vedhanayagam Priya

    Full Text Available The E-commerce zone is crowded with many Internet users. Medical E-commerce has had significant growth in part because of a great deal of growth in the Indian E-commerce field. Medical E-commerce sites use cloud computing to guarantee a high quality of service anywhere and anytime in the world. For online access, the customer's expectations are very high. Medical E-commerce retailers are directed towards cloud service providers based on their quality of service. During online shopping, impatient customers may abandon a specific medical E-commerce shopping cart due to slow response. This is quite difficult to endure for a medical E-commerce firm. The research described herein observed the effect of shopping cart abandonment on medical E-commerce websites deployed in cloud computing. The impact of the idle virtual machine on customer impatience during medical E-commerce shopping was also studied. The ultimate aim of this study was to propose a stochastic queueing model and to yield results through probability generating functions. The results of the model may be highly useful for a medical E-commerce firm facing customer impatience, so as to design its service system to offer satisfactory quality of service. Keywords: Cloud computing, Queueing, Virtual machine, E-commerce, Cart abandonment, Quality of Service

  15. Prediksi Kerawanan Wilayah Terhadap Tindak Pencurian Sepeda Motor Menggunakan Metode (SARIMA Dan CART

    Directory of Open Access Journals (Sweden)

    Pradita Eko Prasetyo Utomo

    2017-07-01

    Full Text Available Motor vehicle theft is a crime that is most common in Indonesia. Growth of vehicle motorcycle significant in each year accompanied by the increasing theft of motorcycles in each year, we need a system that is able to forecast the development and the theft of the motorcycle. This research proposes the development of forecasting models vulnerability criminal offense of theft of motorcycles with ARIMA forecasting method. This method not only forecast from variable of theft but also residents, vehicles and unemployment. The study also determined the classification level of vulnerability to the crime of theft of a motorcycle using a method based on the Decision Tree CART ARIMA forecasting method. Forecasting time series data with ARIMA method performed by each of the variables to produce the best ARIMA forecasting model which varies based on the data pattern of each of those variables. The results of classification by CART method to get the value of accuracy of 92% for the city of Yogyakarta and 85% for DIY. Based on the above, the results of ARIMA forecasting and classification CART can be used in determining the level of vulnerability to the crime of theft of motorcycles.

  16. Parallelization characteristics of the DeCART code

    International Nuclear Information System (INIS)

    Cho, J. Y.; Joo, H. G.; Kim, H. Y.; Lee, C. C.; Chang, M. H.; Zee, S. Q.

    2003-12-01

    This report is to describe the parallelization characteristics of the DeCART code and also examine its parallel performance. Parallel computing algorithms are implemented to DeCART to reduce the tremendous computational burden and memory requirement involved in the three-dimensional whole core transport calculation. In the parallelization of the DeCART code, the axial domain decomposition is first realized by using MPI (Message Passing Interface), and then the azimuthal angle domain decomposition by using either MPI or OpenMP. When using the MPI for both the axial and the angle domain decomposition, the concept of MPI grouping is employed for convenient communication in each communication world. For the parallel computation, most of all the computing modules except for the thermal hydraulic module are parallelized. These parallelized computing modules include the MOC ray tracing, CMFD, NEM, region-wise cross section preparation and cell homogenization modules. For the distributed allocation, most of all the MOC and CMFD/NEM variables are allocated only for the assigned planes, which reduces the required memory by a ratio of the number of the assigned planes to the number of all planes. The parallel performance of the DeCART code is evaluated by solving two problems, a rodded variation of the C5G7 MOX three-dimensional benchmark problem and a simplified three-dimensional SMART PWR core problem. In the aspect of parallel performance, the DeCART code shows a good speedup of about 40.1 and 22.4 in the ray tracing module and about 37.3 and 20.2 in the total computing time when using 48 CPUs on the IBM Regatta and 24 CPUs on the LINUX cluster, respectively. In the comparison between the MPI and OpenMP, OpenMP shows a somewhat better performance than MPI. Therefore, it is concluded that the first priority in the parallel computation of the DeCART code is in the axial domain decomposition by using MPI, and then in the angular domain using OpenMP, and finally the angular

  17. Wind turbines and health

    International Nuclear Information System (INIS)

    Rideout, K.; Copes, R.; Bos, C.

    2010-01-01

    This document summarized the potential health hazards associated with wind turbines, such as noise and low frequency sound, vibration and infrasound; electromagnetic fields (EMF); shadow flicker; and ice throw and structural failure. Various symptoms can be attributed to wind turbines, including dizziness, sleep disruption, and headaches. A review of available research regarding potential health affects to residents living in close proximity to wind turbines showed that the sound level associated with wind turbines at common residential setbacks is not sufficient to damage hearing, but may lead to annoyance and sleep disturbance. Research has shown that wind turbines are not a significant source of EMF exposure, and although shadows caused by the blades may be annoying, they are not likely to cause epileptic seizures at normal operational speeds. The risk of injury from ice throw can be minimized with setbacks of 200 to 400 m. Examples of Canadian wind turbine setback guidelines and regulations were also offered. It was concluded that setbacks and operational guidelines can be utilized in combination to address safety hazards, sound levels, land use issues, and impacts on people. 46 refs., 2 tabs., 2 figs.

  18. CAR-T therapy for leukemia: progress and challenges.

    Science.gov (United States)

    Wang, Xin; Xiao, Qing; Wang, Zhe; Feng, Wen-Li

    2017-04-01

    Despite the rapid development of therapeutic strategies, leukemia remains a type of difficult-to-treat hematopoietic malignancy that necessitates introduction of more effective treatment options to improve life expectancy and quality of patients. Genetic engineering in adoptively transferred T cells to express antigen-specific chimeric antigen receptors (CARs) has proved highly powerful and efficacious in inducing sustained responses in patients with refractory malignancies, as exemplified by the success of CD19-targeting CAR-T treatment in patients with relapsed acute lymphoblastic leukemia. Recent strategies, including manipulating intracellular activating domains and transducing viral vectors, have resulted in better designed and optimized CAR-T cells. This is further facilitated by the rapid identification of an accumulating number of potential leukemic antigens that may serve as therapeutic targets for CAR-T cells. This review will provide a comprehensive background and scrutinize recent important breakthrough studies on anti-leukemia CAR-T cells, with focus on recently identified antigens for CAR-T therapy design and approaches to overcome critical challenges. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Implementation of Generalized Adjoint Equation Solver for DeCART

    International Nuclear Information System (INIS)

    Han, Tae Young; Cho, Jin Young; Lee, Hyun Chul; Noh, Jae Man

    2013-01-01

    In this paper, the generalized adjoint solver based on the generalized perturbation theory is implemented on DeCART and the verification calculations were carried out. As the results, the adjoint flux for the general response coincides with the reference solution and it is expected that the solver could produce the parameters for the sensitivity and uncertainty analysis. Recently, MUSAD (Modules of Uncertainty and Sensitivity Analysis for DeCART) was developed for the uncertainty analysis of PMR200 core and the fundamental adjoint solver was implemented into DeCART. However, the application of the code was limited to the uncertainty to the multiplication factor, k eff , because it was based on the classical perturbation theory. For the uncertainty analysis to the general response as like the power density, it is necessary to develop the analysis module based on the generalized perturbation theory and it needs the generalized adjoint solutions from DeCART. In this paper, the generalized adjoint solver is implemented on DeCART and the calculation results are compared with the results by TSUNAMI of SCALE 6.1

  20. IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor.

    Science.gov (United States)

    Adachi, Keishi; Kano, Yosuke; Nagai, Tomohiko; Okuyama, Namiko; Sakoda, Yukimi; Tamada, Koji

    2018-04-01

    Infiltration, accumulation, and survival of chimeric antigen receptor T (CAR-T) cells in solid tumors is crucial for tumor clearance. We engineered CAR-T cells to express interleukin (IL)-7 and CCL19 (7 × 19 CAR-T cells), as these factors are essential for the maintenance of T-cell zones in lymphoid organs. In mice, 7 × 19 CAR-T cells achieved complete regression of pre-established solid tumors and prolonged mouse survival, with superior anti-tumor activity compared to conventional CAR-T cells. Histopathological analyses showed increased infiltration of dendritic cells (DC) and T cells into tumor tissues following 7 × 19 CAR-T cell therapy. Depletion of recipient T cells before 7 × 19 CAR-T cell administration dampened the therapeutic effects of 7 × 19 CAR-T cell treatment, suggesting that CAR-T cells and recipient immune cells collaborated to exert anti-tumor activity. Following treatment of mice with 7 × 19 CAR-T cells, both recipient conventional T cells and administered CAR-T cells generated memory responses against tumors.

  1. Pengaruh Jarak dan Posisi Nozzle terhadap Daya Turbin Pelton

    OpenAIRE

    Kurniawan, Yani; Pane, Erlanda Augupta; Ismail, Ismail

    2017-01-01

    Pelton Turbine is a turbine which use nozzle as officers the direction of a stream water in order to move around of blade turbine. The rotating of turbine blade efected by some parameters such as the distance of the nozzle, position of nozzle, diameter of nozzle, number of nozzle, and the geometry shape of the blade turbine. An experimental study to analyze the affect of distance and position nozzle to Pelton Turbine of performance. The research method used experiment parameter was position o...

  2. Pengaruh Jarak dan Posisi Nozzle Terhadap Daya Turbin Pelton

    OpenAIRE

    Yani Kurniawan; Erlanda Augupta Pane; Ismail

    2017-01-01

    Pelton Turbine is a turbine which use nozzle as officers the direction of a stream water in order to move around of blade turbine. The rotating of turbine blade efected by some parameters such as the distance of the nozzle, position of nozzle, diameter of nozzle, number of nozzle, and the geometry shape of the blade turbine. An experimental study to analyze the affect of distance and position nozzle to Pelton Turbine of performance. The research method used experiment parameter was position o...

  3. Simulation and Test of a Fuel Cell Hybrid Golf Cart

    Directory of Open Access Journals (Sweden)

    Jingming Liang

    2014-01-01

    Full Text Available This paper establishes the simulation model of fuel cell hybrid golf cart (FCHGC, which applies the non-GUI mode of the Advanced Vehicle Simulator (ADVISOR and the genetic algorithm (GA to optimize it. Simulation of the objective function is composed of fuel consumption and vehicle dynamic performance; the variables are the fuel cell stack power sizes and the battery numbers. By means of simulation, the optimal parameters of vehicle power unit, fuel cell stack, and battery pack are worked out. On this basis, GUI mode of ADVISOR is used to select the rated power of vehicle motor. In line with simulation parameters, an electrical golf cart is refitted by adding a 2 kW hydrogen air proton exchange membrane fuel cell (PEMFC stack system and test the FCHGC. The result shows that the simulation data is effective but it needs improving compared with that of the real cart test.

  4. New development in CAR-T cell therapy.

    Science.gov (United States)

    Wang, Zhenguang; Wu, Zhiqiang; Liu, Yang; Han, Weidong

    2017-02-21

    Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have yielded unprecedented efficacy in B cell malignancies, most remarkably in anti-CD19 CAR-T cells for B cell acute lymphoblastic leukemia (B-ALL) with up to a 90% complete remission rate. However, tumor antigen escape has emerged as a main challenge for the long-term disease control of this promising immunotherapy in B cell malignancies. In addition, this success has encountered significant hurdles in translation to solid tumors, and the safety of the on-target/off-tumor recognition of normal tissues is one of the main reasons. In this mini-review, we characterize some of the mechanisms for antigen loss relapse and new strategies to address this issue. In addition, we discuss some novel CAR designs that are being considered to enhance the safety of CAR-T cell therapy in solid tumors.

  5. Improving Odometric Accuracy for an Autonomous Electric Cart

    Directory of Open Access Journals (Sweden)

    Jonay Toledo

    2018-01-01

    Full Text Available In this paper, a study of the odometric system for the autonomous cart Verdino, which is an electric vehicle based on a golf cart, is presented. A mathematical model of the odometric system is derived from cart movement equations, and is used to compute the vehicle position and orientation. The inputs of the system are the odometry encoders, and the model uses the wheels diameter and distance between wheels as parameters. With this model, a least square minimization is made in order to get the nominal best parameters. This model is updated, including a real time wheel diameter measurement improving the accuracy of the results. A neural network model is used in order to learn the odometric model from data. Tests are made using this neural network in several configurations and the results are compared to the mathematical model, showing that the neural network can outperform the first proposed model.

  6. Improving Odometric Accuracy for an Autonomous Electric Cart.

    Science.gov (United States)

    Toledo, Jonay; Piñeiro, Jose D; Arnay, Rafael; Acosta, Daniel; Acosta, Leopoldo

    2018-01-12

    In this paper, a study of the odometric system for the autonomous cart Verdino, which is an electric vehicle based on a golf cart, is presented. A mathematical model of the odometric system is derived from cart movement equations, and is used to compute the vehicle position and orientation. The inputs of the system are the odometry encoders, and the model uses the wheels diameter and distance between wheels as parameters. With this model, a least square minimization is made in order to get the nominal best parameters. This model is updated, including a real time wheel diameter measurement improving the accuracy of the results. A neural network model is used in order to learn the odometric model from data. Tests are made using this neural network in several configurations and the results are compared to the mathematical model, showing that the neural network can outperform the first proposed model.

  7. New development in CAR-T cell therapy

    Directory of Open Access Journals (Sweden)

    Zhenguang Wang

    2017-02-01

    Full Text Available Abstract Chimeric antigen receptor (CAR-engineered T cells (CAR-T cells have yielded unprecedented efficacy in B cell malignancies, most remarkably in anti-CD19 CAR-T cells for B cell acute lymphoblastic leukemia (B-ALL with up to a 90% complete remission rate. However, tumor antigen escape has emerged as a main challenge for the long-term disease control of this promising immunotherapy in B cell malignancies. In addition, this success has encountered significant hurdles in translation to solid tumors, and the safety of the on-target/off-tumor recognition of normal tissues is one of the main reasons. In this mini-review, we characterize some of the mechanisms for antigen loss relapse and new strategies to address this issue. In addition, we discuss some novel CAR designs that are being considered to enhance the safety of CAR-T cell therapy in solid tumors.

  8. Ceramics for Turbine Engine Applications.

    Science.gov (United States)

    1980-03-01

    permet de travailler en compression. 2 - LES TURBINES CONTRAROTATIVES Connues depuis plus de 50 ans dsns lea turbines A vapeur (A grilles radiales) lea...AD-AO87 594 ADVISORY GROUP FOR AEROSPACE RESEARCH AND DEVELOPMENT--ETC F/6 11/2 CERAMICS FOR TURBINE ENGINE APPICATIONS.(U) MAR 8G H M GURTE, J...for Turbine Engine Applications ( X.,, ~LAJ DISTRIBUTION AND AVAILABILITY Ths ai’-t~ ~ru O ACK COVER forp"~ ~So’ 8 6 0 40 NORTH ATLANTIC TREATY

  9. Simulations research of the global predictive control with self-adaptive in the gas turbine of the nuclear power plant

    International Nuclear Information System (INIS)

    Su Jie; Xia Guoqing; Zhang Wei

    2007-01-01

    For further improving the dynamic control capabilities of the gas turbine of the nuclear power plant, this paper puts forward to apply the algorithm of global predictive control with self-adaptive in the rotate speed control of the gas turbine, including control structure and the design of controller in the base of expounding the math model of the gas turbine of the nuclear power plant. the simulation results show that the respond of the change of the gas turbine speed under the control algorithm of global predictive control with self-adaptive is ten second faster than that under the PID control algorithm, and the output value of the gas turbine speed under the PID control algorithm is 1%-2% higher than that under the control slgorithm of global predictive control with self-adaptive. It shows that the algorithm of global predictive control with self-adaptive can better control the output of the speed of the gas turbine of the nuclear power plant and get the better control effect. (authors)

  10. An rf communications system for the West Valley transfer cart

    International Nuclear Information System (INIS)

    Crutcher, R.I.; Moore, M.R.

    1993-01-01

    A prototype radio frequency communications system for digital data was designed and built by Oak Ridge National Laboratory for use in controlling the vitrification facility transfer cart at the West Valley Nuclear Services facility in New York. The communications system provides bidirectional wireless data transfer between the operator control station and the material transfer cart. The system was designed to operate in radiation fields of 10 4 R/h while withstanding a total integrated dose of 10 7 R of gamma radiation. Implementation of antenna spatial diversity, automatic gain control, and spectral processing improves operation in the reflective environment of the metal-lined reprocessing cells

  11. Vermeer et les cartes de géographie.

    Directory of Open Access Journals (Sweden)

    Jean MARTINON

    1987-09-01

    Full Text Available De nombreux tableaux de Vermeer sont «tapissés» de cartes de géographie. Objets scientifiques, elles témoignent de l'importance des découvertes au XVIIe siècle en Europe et de l'ouverture des Pays-Bas sur le monde. Objets de décoration, les cartes tendent à se confondre avec des représentations paysagères. Objets romanesques, elles introduisent le lointain et le rêve dans les intérieurs confinés de la bourgeoisie d'Amsterdam.

  12. 风力机控制建模及仿真研究%The Control Modeling & Its Simulation Research on Wind Turbines

    Institute of Scientific and Technical Information of China (English)

    石磊; 王起琦; 杨帆; 刘永昌

    2015-01-01

    In view of fossil fuel’s drying up and its inherent contaminant to the environment,wind energy has become one of the fastest growing and effective energy source,for it is abundant,secure,clean and renewable. In consideration of the low density of wind energy,the exaltation of the efficiency of wind energy has become a problem which is urgently needed to resolved for wind power generation. The output power of the wind turbine can be changed by the regulation of the running status of the wind turbine,which can remain the output power maximum when the different conditions,and realize the most valid exploitation of the wind energy .This paper is in the purpose of studying the principle of generating electricity of the doubly-fed induction generators for wind turbines,and studying the work principle of the wind turbine as a key. By researching the physical meaning and the relations of each parameter of the turbine,the relations between the output power of the turbine,wind speed,tip speed ratio,rotational speed of the machine and the pitch angle can be deduced. By researching the running process of the turbine,the controlling principle and movement process of the pitch angle can be deduced,and the running status of the turbine can be known at arbitrary wind speed. At present there are two main kinds of methods to control the output power of wind turbine,one is established based on the relation between the output power of the turbine and the wind speed;Another is established based on the relation between the output power of the turbine and the rotational speed of the machine. This paper carries on the analysis to these two kinds of methods,points out the shortages from the actual angle,and makes the assumption of four segments of the running process of the turbine based on the relation between the power and rotational speed. Taking the G58-850KW turbine as an example,the deduction in theory can be verified by the known datum,and the result enunciates that the method of

  13. Implementation of a generalized actuator disk wind turbine model into the weather research and forecasting model for large-eddy simulation applications

    Energy Technology Data Exchange (ETDEWEB)

    Mirocha, J. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kosovic, B. [National Center for Atmospheric Research, Boulder, CO (United States); Aitken, M. L. [Univ. of Colorado, Boulder, CO (United States); Lundquist, J. K. [Univ. of Colorado, Boulder, CO (United States); National Renewable Energy Lab., Golden, CO (United States)

    2014-01-10

    A generalized actuator disk (GAD) wind turbine parameterization designed for large-eddy simulation (LES) applications was implemented into the Weather Research and Forecasting (WRF) model. WRF-LES with the GAD model enables numerical investigation of the effects of an operating wind turbine on and interactions with a broad range of atmospheric boundary layer phenomena. Numerical simulations using WRF-LES with the GAD model were compared with measurements obtained from the Turbine Wake and Inflow Characterization Study (TWICS-2011), the goal of which was to measure both the inflow to and wake from a 2.3-MW wind turbine. Data from a meteorological tower and two light-detection and ranging (lidar) systems, one vertically profiling and another operated over a variety of scanning modes, were utilized to obtain forcing for the simulations, and to evaluate characteristics of the simulated wakes. Simulations produced wakes with physically consistent rotation and velocity deficits. Two surface heat flux values of 20 W m–2 and 100 W m–2 were used to examine the sensitivity of the simulated wakes to convective instability. Simulations using the smaller heat flux values showed good agreement with wake deficits observed during TWICS-2011, whereas those using the larger value showed enhanced spreading and more-rapid attenuation. This study demonstrates the utility of actuator models implemented within atmospheric LES to address a range of atmospheric science and engineering applications. In conclusion, validated implementation of the GAD in a numerical weather prediction code such as WRF will enable a wide range of studies related to the interaction of wind turbines with the atmosphere and surface.

  14. Development of Low Price Turbine Control System

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, C.K.; Kim, J.A.; Jeong, W.J.; Choi, I.K.; Woo, J.H. [Korea Electric Power Research Institute, Taejon (Korea)

    2002-07-01

    This report is final research results of ''Development of Low Price Turbine Control System''. It describes test such as turbine startup, generator synchronization, rated load operation, simulation after manufacturing turbine control system. (author). 45 figs., 11 tabs.

  15. CART neurons in the arcuate nucleus and lateral hypothalamic area exert differential controls on energy homeostasis

    Directory of Open Access Journals (Sweden)

    Jackie Lau

    2018-01-01

    Full Text Available Objective: The cocaine- and amphetamine-regulated transcript (CART codes for a pivotal neuropeptide important in the control of appetite and energy homeostasis. However, limited understanding exists for the defined effector sites underlying CART function, as discrepant effects of central CART administration have been reported. Methods: By combining Cart-cre knock-in mice with a Cart adeno-associated viral vector designed using the flip-excision switch (AAV-FLEX technology, specific reintroduction or overexpression of CART selectively in CART neurons in the arcuate nucleus (Arc and lateral hypothalamic area (LHA, respectively, was achieved. The effects on energy homeostasis control were investigated. Results: Here we show that CART neuron-specific reintroduction of CART into the Arc and LHA leads to distinct effects on energy homeostasis control. Specifically, CART reintroduction into the Arc of otherwise CART-deficient Cartcre/cre mice markedly decreased fat mass and body weight, whereas CART reintroduction into the LHA caused significant fat mass gain and lean mass loss, but overall unaltered body weight. The reduced adiposity in ArcCART;Cartcre/cre mice was associated with an increase in both energy expenditure and physical activity, along with significantly decreased Npy mRNA levels in the Arc but with no change in food consumption. Distinctively, the elevated fat mass in LHACART;Cartcre/cre mice was accompanied by diminished insulin responsiveness and glucose tolerance, greater spontaneous food intake, and reduced energy expenditure, which is consistent with the observed decrease of brown adipose tissue temperature. This is also in line with significantly reduced tyrosine hydroxylase (Th and notably increased corticotropin-releasing hormone (Crh mRNA expressions in the paraventricular nucleus (PVN. Conclusions: Taken together, these results identify catabolic and anabolic effects of CART in the Arc and LHA, respectively, demonstrating for

  16. Overview of the West Valley Vitrification Facility transfer cart control system

    International Nuclear Information System (INIS)

    Bradley, E.C.; Rupple, F.R.

    1993-01-01

    Oak Ridge National Laboratory (ORNL) has designed the control system for the West Valley Demonstration Project Vitrification Facility transfer cart. The transfer cart will transfer canisters of vitrified high-level waste remotely within the Vitrification Facility. The control system will operate the cart under battery power by wireless control. The equipment includes cart mounted control electronics, battery charger, control pendants, engineer's console, and facility antennas

  17. Gas turbines

    Energy Technology Data Exchange (ETDEWEB)

    Farahan, E.; Eudaly, J.P.

    1978-10-01

    This evaluation provides performance and cost data for commercially available simple- and regenerative-cycle gas turbines. Intercooled, reheat, and compound cycles are discussed from theoretical basis only, because actual units are not currently available, except on a special-order basis. Performance characteristics investigated include unit efficiency at full-load and off-design conditions, and at rated capacity. Costs are tabulated for both simple- and regenerative-cycle gas turbines. The output capacity of the gas turbines investigated ranges from 80 to 134,000 hp for simple units and from 12,000 to 50,000 hp for regenerative units.

  18. Next Generation Wind Turbine

    Energy Technology Data Exchange (ETDEWEB)

    Cheraghi, S. Hossein [Western New England Univ., Springfield, MA (United States); Madden, Frank [FloDesign Wind Turbine Corp., Waltham, MA (United States)

    2012-09-01

    The goal of this collaborative effort between Western New England University's College of Engineering and FloDesign Wind Turbine (FDWT) Corporation to wok on a novel areodynamic concept that could potentially lead to the next generation of wind turbines. Analytical studies and early scale model tests of FDWT's Mixer/Ejector Wind Turbine (MEWT) concept, which exploits jet-age advanced fluid dynamics, indicate that the concept has the potential to significantly reduce the cost of electricity over conventional Horizontal Axis Wind Turbines while reducing land usage. This project involved the design, fabrication, and wind tunnel testing of components of MEWT to provide the research and engineering data necessary to validate the design iterations and optimize system performance. Based on these tests, a scale model prototype called Briza was designed, fabricated, installed and tested on a portable tower to investigate and improve the design system in real world conditions. The results of these scale prototype efforts were very promising and have contributed significantly to FDWT's ongoing development of a product scale wind turbine for deployment in multiple locations around the U.S. This research was mutually beneficial to Western New England University, FDWT, and the DOE by utilizing over 30 student interns and a number of faculty in all efforts. It brought real-world wind turbine experience into the classroom to further enhance the Green Engineering Program at WNEU. It also provided on-the-job training to many students, improving their future employment opportunities, while also providing valuable information to further advance FDWT's mixer-ejector wind turbine technology, creating opportunities for future project innovation and job creation.

  19. Offshore Wind Turbine Design

    DEFF Research Database (Denmark)

    Frandsen, Sten; Hansen, Erik Asp; Ibsen, Lars Bo

    2006-01-01

    Current offshore wind turbine design methods have matured to a 1st generation state, manifested in the draft of a possible standard, IEC 61400-3 (2005). It is now time to investigate the possibilities of improving existing methods. To do so in an efficient manner a clear identification of the most...... important uncertainty drivers specific for offshore wind turbine design loads is required. Describing the initial efforts in a Danish research project, the paper points to focal points for research and development. These are mainly: soil-structure interaction, improved modelling of wave loads from deep...

  20. Smart Shopping Carts: How Real-Time Feedback Influences Spending

    NARCIS (Netherlands)

    Ittersum, van K.; Wansink, B.; Pennings, J.M.E.; Sheehan, D.

    2013-01-01

    Although interest in smart shopping carts is increasing, both retailers and consumer groups have concerns about how real-time spending feedback will influence shopping behavior. Building on budgeting and spending theories, the authors conduct three lab and grocery store experiments that robustly

  1. Smart shopping carts : How real-time feedback influences spending

    NARCIS (Netherlands)

    van Ittersum, Koert; Wansink, B.; Pennings, J.M.E.; Sheehan, D.

    Although interest in smart shopping carts is increasing, both retailers and consumer groups have concerns about how real-time spending feedback will influence shopping behavior. Building on budgeting and spending theories, the authors conduct three lab and grocery store experiments that robustly

  2. Smart shopping carts : How real-time feedback influences spending

    NARCIS (Netherlands)

    van Ittersum, Koert; Wansink, B.; Pennings, J.M.E.; Sheehan, D.

    2013-01-01

    Although interest in smart shopping carts is increasing, both retailers and consumer groups have concerns about how real-time spending feedback will influence shopping behavior. Building on budgeting and spending theories, the authors conduct three lab and grocery store experiments that robustly

  3. Acceptance Test Report for Gamma Carts A and B

    International Nuclear Information System (INIS)

    FULLER, P.J.

    2000-01-01

    Report of Shop Test of the Gamma Cart System to be used in the AZ-101 Mixer Pump Demonstration Test. Reports of the hardware and software tests. The objective of the testing was to verify in the shop that the hardware and software operated according to design specifications before field-testing and installation

  4. TEST OF AN ANIMAL DRAWN FIELD IMPLEMENT CART

    Directory of Open Access Journals (Sweden)

    Paolo Spugnoli

    2008-06-01

    Full Text Available The field performance of a horse-drawn hitch cart equipped with a PTO system powered by the two cart ground wheels have been investigated. For this purpose field tests on clay and turf soil, with varying ballast and PTO torque, have been carried out pulling the cart by a tractor. Preliminary tests were aimed at assessing the traction capability of horse breed. These tests showed that the mean draught force given by two of these horses was 173daN, average working speed was about 1m*s-1, resulting a mean draught power developed by each horse of about 0.86kW. The PTO cart system performance has shown that the torque has not exceeded 2.4daN*m, maximum draught or PTO power was 1.15kW, rotation speed just higher than 400min-1, with mean efficiency of about 50%. These values are consistent with horse performance and small haymaking, fertilizing, seeding and chemical application machine requirements.

  5. Pelton turbines

    CERN Document Server

    Zhang, Zhengji

    2016-01-01

    This book concerns the theoretical foundations of hydromechanics of Pelton turbines from the engineering viewpoint. For reference purposes, all relevant flow processes and hydraulic aspects in a Pelton turbine have been analyzed completely and systematically. The analyses especially include the quantification of all possible losses existing in the Pelton turbine and the indication of most available potential for further enhancing the system efficiency. As a guideline the book therefore supports further developments of Pelton turbines with regard to their hydraulic designs and optimizations. It is thus suitable for the development and design engineers as well as those working in the field of turbo machinery. Many laws described in the book can also be directly used to simplify aspects of computational fluid dynamics (CFD) or to develop new computational methods. The well-executed examples help better understand the related flow mechanics.

  6. Deflector plants turbine aeration

    International Nuclear Information System (INIS)

    Miller, D.E.; Sheppard, A.R.; Widener, D.W.

    1991-01-01

    Water quality requirements have become a focal point in recent re-licensing of hydroelectric projects. The Federal Energy Regulatory Commission has significantly increased the relevance of license conditions to insure that turbine discharges meet state or other specific criteria for dissolved oxygen (D.O.). Due to naturally occurring depletion of D.O. at increased depths in large reservoirs, water withdrawn from this strata may result in unacceptably low levels of D.O. Different researchers have evaluated various methods of improving D.O. content in hydro turbine discharges, including; diffusers, weirs, oxygen injection, and variations of turbine venting. The authors describe an approach called deflector plate turbine aeration. This computer based, engineered approach allows systems to be evaluated, designed, and installed with predictable performance and costs. Many experts in this field now agree that, to the extent practical, turbine venting offers the most dependable, maintenance free, and cost effective solution to the low D.O. problem. The approach presented in this paper has resulted in proven results

  7. Research on improved design of airfoil profiles based on the continuity of airfoil surface curvature of wind turbines

    DEFF Research Database (Denmark)

    Chen, Jin; Cheng, Jiangtao; Shen, Wenzhong

    2013-01-01

    Aerodynamic of airfoil performance is closely related to the continuity of its surface curvature, and airfoil profiles with a better aerodynamic performance plays an important role in the design of wind turbine. The surface curvature distribution along the chord direction and pressure distributio...

  8. Testing of the West Valley Vitrification Facility transfer cart control system

    International Nuclear Information System (INIS)

    Halliwell, J.W.; Bradley, E.C.

    1995-01-01

    Oak Ridge National Laboratory (ORNL) has designed and tested the control system for the West Valley Demonstration Project Vitrification Facility transfer cart. The transfer cart will transfer canisters of vitrified high-level waste remotely within the Vitrification Facility. The control system operates the cart under battery power by wireless control. The equipment includes cart-mounted control electronics, battery charger, control pendants, engineer's console, and facility antennas. Testing was performed in several phases of development: (1) prototype equipment was built and tested during design, (2) board-level testing was then performed at ORNL during fabrication, and (3) system-level testing was then performed by ORNL at the fabrication subcontractor's facility for the completed cart system. These tests verified (1) the performance of the cart relative to design requirements and (2) operation of various built-in cart features. The final phase of testing is planned to be conducted during installation at the West Valley Vitrification Facility

  9. Finding and applying evidence during clinical rounds: the "evidence cart".

    Science.gov (United States)

    Sackett, D L; Straus, S E

    1998-10-21

    Physicians need easy access to evidence for clinical decisions while they care for patients but, to our knowledge, no investigators have assessed use of evidence during rounds with house staff. To determine if it was feasible to find and apply evidence during clinical rounds, using an "evidence cart" that contains multiple sources of evidence and the means for projecting and printing them. Descriptive feasibility study of use of evidence during 1 month (April 1997) and anonymous questionnaire (May 1997). General medicine inpatient service. Medical students, house staff, fellows, and attending consultant. Evidence cart that included 2 secondary sources developed by the department (critically appraised topics [CATs] and Redbook), Best Evidence, JAMA Rational Clinical Examination series, the Cochrane Library, MEDLINE, a physical examination textbook, a radiology anatomy textbook, and a Simulscope, which allows several people to listen simultaneously to the same signs on physical examination. Number of times sources were used, type of sources searched and success of searches, time needed to search, and whether the search affected patient care. The evidence cart was used 98 times, but could not be taken on bedside rounds because of its bulk; hard copies of several sources were taken instead. When the evidence cart was used during team rounds and student rounds, some sources could be accessed quickly enough (10.2-25.4 seconds) to be practical on our service. Of 98 searches, 79 (81%) sought evidence that could affect diagnostic and/or treatment decisions. Seventy-one (90%) of 79 searches regarding patient management were successful, and when assessed from the perspective of the most junior team members responsible for each patient's evaluation and management, 37 (52%) of the 71 successful searches confirmed their current or tentative diagnostic or treatment plans, 18 (25%) led to a new diagnostic skill, an additional test, or a new management decision, and 16 (23

  10. Environmental assessment for the Atmospheric Radiation Measurement (ARM) Program: Southern Great Plains Cloud and Radiation Testbed (CART) site

    International Nuclear Information System (INIS)

    Policastro, A.J.; Pfingston, J.M.; Maloney, D.M.; Wasmer, F.; Pentecost, E.D.

    1992-03-01

    The Atmospheric Radiation Measurement (ARM) Program is aimed at supplying improved predictive capability of climate change, particularly the prediction of cloud-climate feedback. The objective will be achieved by measuring the atmospheric radiation and physical and meteorological quantities that control solar radiation in the earth's atmosphere and using this information to test global climate and related models. The proposed action is to construct and operate a Cloud and Radiation Testbed (CART) research site in the southern Great Plains as part of the Department of Energy's Atmospheric Radiation Measurement Program whose objective is to develop an improved predictive capability of global climate change. The purpose of this CART research site in southern Kansas and northern Oklahoma would be to collect meteorological and other scientific information to better characterize the processes controlling radiation transfer on a global scale. Impacts which could result from this facility are described

  11. Environmental assessment for the Atmospheric Radiation Measurement (ARM) Program: Southern Great Plains Cloud and Radiation Testbed (CART) site

    Energy Technology Data Exchange (ETDEWEB)

    Policastro, A.J.; Pfingston, J.M.; Maloney, D.M.; Wasmer, F.; Pentecost, E.D.

    1992-03-01

    The Atmospheric Radiation Measurement (ARM) Program is aimed at supplying improved predictive capability of climate change, particularly the prediction of cloud-climate feedback. The objective will be achieved by measuring the atmospheric radiation and physical and meteorological quantities that control solar radiation in the earth`s atmosphere and using this information to test global climate and related models. The proposed action is to construct and operate a Cloud and Radiation Testbed (CART) research site in the southern Great Plains as part of the Department of Energy`s Atmospheric Radiation Measurement Program whose objective is to develop an improved predictive capability of global climate change. The purpose of this CART research site in southern Kansas and northern Oklahoma would be to collect meteorological and other scientific information to better characterize the processes controlling radiation transfer on a global scale. Impacts which could result from this facility are described.

  12. Exploring the social determinants of mental health service use using intersectionality theory and CART analysis.

    Science.gov (United States)

    Cairney, John; Veldhuizen, Scott; Vigod, Simone; Streiner, David L; Wade, Terrance J; Kurdyak, Paul

    2014-02-01

    Fewer than half of individuals with a mental disorder seek formal care in a given year. Much research has been conducted on the factors that influence service use in this population, but the methods generally used cannot easily identify the complex interactions that are thought to exist. In this paper, we examine predictors of subsequent service use among respondents to a population health survey who met criteria for a past-year mood, anxiety or substance-related disorder. To determine service use, we use an administrative database including all physician consultations in the period of interest. To identify predictors, we use classification tree (CART) analysis, a data mining technique with the ability to identify unsuspected interactions. We compare results to those from logistic regression models. We identify 1213 individuals with past-year disorder. In the year after the survey, 24% (n=312) of these had a mental health-related physician consultation. Logistic regression revealed that age, sex and marital status predicted service use. CART analysis yielded a set of rules based on age, sex, marital status and income adequacy, with marital status playing a role among men and by income adequacy important among women. CART analysis proved moderately effective overall, with agreement of 60%, sensitivity of 82% and specificity of 53%. Results highlight the potential of data-mining techniques to uncover complex interactions, and offer support to the view that the intersection of multiple statuses influence health and behaviour in ways that are difficult to identify with conventional statistics. The disadvantages of these methods are also discussed.

  13. Field Testing of Feedforward Collective Pitch Control on the CART2 Using a Nacelle-Based Lidar Scanner

    International Nuclear Information System (INIS)

    Schlipf, David; Haizmann, Florian; Hofsäß, Martin; Cheng, Po Wen; Fleming, Paul; Scholbrock, Andrew; Wright, Alan

    2014-01-01

    This work presents the results from a field test of LIDAR assisted collective pitch control using a scanning LIDAR device installed on the nacelle of a mid-scale research turbine. A nonlinear feedforward controller is extended by an adaptive filter to remove all uncorrelated frequencies of the wind speed measurement to avoid unnecessary control action. Positive effects on the rotor speed regulation as well as on tower, blade and shaft loads have been observed in the case that the previous measured correlation and timing between the wind preview and the turbine reaction are accomplish. The feedforward controller had negative impact, when the LIDAR measurement was disturbed by obstacles in front of the turbine. This work proves, that LIDAR is valuable tool for wind turbine control not only in simulations but also under real conditions. Furthermore, the paper shows that further understanding of the relationship between the wind measurement and the turbine reaction is crucial to improve LIDAR assisted control of wind turbines

  14. Field Testing of Feedforward Collective Pitch Control on the CART2 Using a Nacelle-Based Lidar Scanner

    Science.gov (United States)

    Schlipf, David; Fleming, Paul; Haizmann, Florian; Scholbrock, Andrew; Hofsäß, Martin; Wright, Alan; Cheng, Po Wen

    2014-12-01

    This work presents the results from a field test of LIDAR assisted collective pitch control using a scanning LIDAR device installed on the nacelle of a mid-scale research turbine. A nonlinear feedforward controller is extended by an adaptive filter to remove all uncorrelated frequencies of the wind speed measurement to avoid unnecessary control action. Positive effects on the rotor speed regulation as well as on tower, blade and shaft loads have been observed in the case that the previous measured correlation and timing between the wind preview and the turbine reaction are accomplish. The feedforward controller had negative impact, when the LIDAR measurement was disturbed by obstacles in front of the turbine. This work proves, that LIDAR is valuable tool for wind turbine control not only in simulations but also under real conditions. Furthermore, the paper shows that further understanding of the relationship between the wind measurement and the turbine reaction is crucial to improve LIDAR assisted control of wind turbines.

  15. Design of Wind Turbine Vibration Monitoring System

    Directory of Open Access Journals (Sweden)

    Shoubin Wang

    2013-04-01

    Full Text Available In order to ensure safety of wind turbine operation and to reduce the occurrence of faults as well as to improve the reliability of wind turbine operation, a vibration monitoring for wind turbine is developed. In this paper, it analyses the enlargement of all the parts of the structure and the working mechanism, the research method of wind turbine operation vibration is introduced, with the focus being the use of the sensor principle. Finally the hardware design and software of this system is introduced and the main function of this system is described, which realizes condition monitoring of the work state of wind turbines.

  16. Aeroelastic instability problems for wind turbines

    DEFF Research Database (Denmark)

    Hansen, Morten Hartvig

    2007-01-01

    This paper deals with the aeroelostic instabilities that have occurred and may still occur for modem commercial wind turbines: stall-induced vibrations for stall-turbines, and classical flutter for pitch-regulated turbines. A review of previous works is combined with derivations of analytical...... stiffness and chordwise position of the center of gravity along the blades are the main parameters for flutter. These instability characteristics are exemplified by aeroelastic stability analyses of different wind turbines. The review of each aeroelastic instability ends with a list of current research...... issues that represent unsolved aeroelostic instability problems for wind turbines. Copyright (c) 2007 John Wiley & Sons, Ltd....

  17. Wind turbine

    Science.gov (United States)

    Cheney, Jr., Marvin C.

    1982-01-01

    A wind turbine of the type having an airfoil blade (15) mounted on a flexible beam (20) and a pitch governor (55) which selectively, torsionally twists the flexible beam in response to wind turbine speed thereby setting blade pitch, is provided with a limiter (85) which restricts unwanted pitch change at operating speeds due to torsional creep of the flexible beam. The limiter allows twisting of the beam by the governor under excessive wind velocity conditions to orient the blades in stall pitch positions, thereby preventing overspeed operation of the turbine. In the preferred embodiment, the pitch governor comprises a pendulum (65,70) which responds to changing rotor speed by pivotal movement, the limiter comprising a resilient member (90) which engages an end of the pendulum to restrict further movement thereof, and in turn restrict beam creep and unwanted blade pitch misadjustment.

  18. A School Experiment in Kinematics: Shooting from a Ballistic Cart

    Science.gov (United States)

    Kranjc, T.; Razpet, N.

    2011-10-01

    Many physics textbooks start with kinematics. In the lab, students observe the motions, describe and make predictions, and get acquainted with basic kinematics quantities and their meaning. Then they can perform calculations and compare the results with experimental findings. In this paper we describe an experiment that is not often done, but is interesting and attractive to students—the ballistic cart, i.e., the shooting of a ball from a cart moving along a slope. For that, one has to be familiar with one-dimensional uniform motion and one-dimensional motion with constant acceleration, as well as curvilinear motion that is a combination of such motions.1,2 The experimental results confirm theoretical predictions.

  19. Pushing, pulling and manoeuvring an industrial cart: a psychophysiological study.

    Science.gov (United States)

    Giagloglou, Evanthia; Radenkovic, Milan; Brankovic, Sasa; Antoniou, Panagiotis; Zivanovic-Macuzic, Ivana

    2017-09-18

    One of the most frequent manual occupational tasks involves the pushing and pulling of a cart. Although several studies have associated health risks with pushing and pulling, the effects are not clear since occupational tasks have social, cognitive and physical components. The present work investigates a real case of a pushing and pulling occupational task from a manufacturing company. The study initially characterizes the case in accordance with Standard No. ISO 11228-2:2007 as low risk. An experiment with 14 individuals during three modalities of pushing and pulling was performed in order to further investigate the task with the application of electrophysiology. At the end, a simple questionnaire was given. The results show electrophysiological differences among the three modalities of pushing and pulling, with a major difference between action with no load and fully loaded with a full range of motions on the cart to handle.

  20. Considerations pertaining to cell collection and administration of industry-manufactured autologous CAR-T cells, in relation to French healthcare organization and regulations.

    Science.gov (United States)

    Chabannon, Christian; Larghero, Jérôme

    2018-05-01

    Access to treatment with CAR-T Cells at European hospitals in general and at French hospitals in particular remains limited, when compared with the situation that prevails in the USA or in certain Asian countries. Multiple reasons explain why European investigators lag behind their US or Chinese colleagues in this clinical research area. Some of these reasons are related to the European and French regulatory landscapes that hamper the design and rapid implementation of organizational solutions needed for safe and efficient administration of CAR-T Cells. We here identify some of these pressing issues and propose some possible paths to move forward. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  1. A cloud climatology of the Southern Great Plains ARM CART

    Energy Technology Data Exchange (ETDEWEB)

    Lazarus, S.M.; Krueger, S.K.; Mace, G.G.

    2000-05-15

    Cloud amount statistics from three different sources were processed and compared. Surface observations from a National Centers for Environmental Prediction dataset were used. The data (Edited Cloud Report; ECR) consist of synoptic weather reports that have been edited to facilitate cloud analysis. Two stations near the Southern Great Plains (SGP) Cloud and Radiation Test Bed (CART) in north-central Oklahoma (Oklahoma City, Oklahoma and Wichita, Kansas) were selected. The ECR data span a 10-yr period from December 1981 to November 1991. The International Satellite Cloud Climatology Project (ISCCP) provided cloud amounts over the SGP CART for an 8-yr period (1983--91). Cloud amounts were also obtained from Micro Pulse Lidar (MPL) and Belfort Ceilometer (BLC) cloud-base height measurements made at the SGP CART over a 1-yr period. The annual and diurnal cycles of cloud amount as a function of cloud height and type were analyzed. The three datasets closely agree for total cloud amount. Good agreement was found in the ECR and MPL-BLC monthly low cloud amounts. With the exception of summer and midday in other seasons, the ISCCP low cloud amount estimates are generally 5%--10% less than the others. The ECR high cloud amount estimates are typically 10%--15% greater than those obtained from either the ISCCP or MPL-BLC datasets. The observed diurnal variations of altocumulus support the authors' model results of radiatively induced circulations.

  2. Regional CAR-T cell infusions for peritoneal carcinomatosis are superior to systemic delivery.

    Science.gov (United States)

    Katz, S C; Point, G R; Cunetta, M; Thorn, M; Guha, P; Espat, N J; Boutros, C; Hanna, N; Junghans, R P

    2016-05-01

    Metastatic spread of colorectal cancer (CRC) to the peritoneal cavity is common and difficult to treat, with many patients dying from malignant bowel obstruction. Chimeric antigen receptor T cell (CAR-T) immunotherapy has shown great promise, and we previously reported murine and phase I clinical studies on regional intrahepatic CAR-T infusion for CRC liver metastases. We are now studying intraperitoneal (IP) delivery of CAR-Ts for peritoneal carcinomatosis. Regional IP infusion of CAR-T resulted in superior protection against carcinoembryonic antigen (CEA+) peritoneal tumors, when compared with systemically infused CAR-Ts. IP CAR-Ts also provided prolonged protection against IP tumor re-challenges and demonstrated an increase in effector memory phenotype over time. IP CAR-Ts provided protection against tumor growth at distant subcutaneous (SC) sites in association with increases in serum IFNγ levels. Given the challenges posed by immunoinhibitory pathways in solid tumors, we combined IP CAR-T treatment with suppressor cell targeting. High frequencies of myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) were found within the IP tumors, with MDSC expressing high levels of immunosuppressive PD-L1. Combinatorial IP CAR-T treatment with depleting antibodies against MDSC and Treg further improved efficacy against peritoneal metastases. Our data support further development of combinatorial IP CAR-T immunotherapy for peritoneal malignancies.

  3. CryoCart Restoration and Vacuum Pipe Construction

    Science.gov (United States)

    Chaidez, Mariana

    2016-01-01

    first completed at the component level. During this process, the igniter of the main engine and the RCS thrusters will be tested under a vacuum. To complete the testing of the components, the test setup first needed to be finalized. The CryoCart is being used to feed the propellants to the test article. The CryoCart is a movable test set-up that was developed in 2009 to provide a mobile platform for testing oxygen/methane systems with hot-fire capability up to 100 lbf. The CryoCart consists of three different systems: Oxygen, Methane, and liquid Nitrogen. The Oxygen and Methane systems are placed into two different carts while the liquid nitrogen system is mainly located in the methane cart. Over the years, the CryoCart has been utilized for different projects and has undergone deterioration. For this reason, a new phase has been developed to rebuild it to working conditions once again. During my internship, I was aiding in the construction and restoration of the CryoCart. In the initial stages of the process, I updated the fluid and electrical schematics for the oxygen, methane, and test article systems. The original CryoCart consisted of an electrical panel that utilized electromechanical relays and a terminal to drive the igniter power and signal, as well as the main fuel and oxygen valves. This electrical panel connected to the CryoCart through various wire harnesses that could be found exiting from the CryoCart. First, it was determined how these harnesses connected to the electromechanical relays so that they worked correctly. Once the electrical system was understood, an alternative for the electromechanical relays and the Molex connectors used throughout the system was sought since these components can often prove to be unreliable. Solid State relays and MIL connectors were purchased to serve as replacements. Upon arrival of the parts, crimping and wiring was completed to install the new solid state relays and MIL connectors. During the replacement of the relays

  4. Marine Hydrokinetic (MHK) Energy Conversion Research at UNH: From Fundamental Studies of Hydrofoil Sections, to Moderate Reynolds Number Turbine Tests in a Tow Tank, to Open Water Deployments at Tidal Energy Test Sites (Invited)

    Science.gov (United States)

    Wosnik, M.; Bachant, P.; Nedyalkov, I.; Rowell, M.; Dufresne, N.; Lyon, V.

    2013-12-01

    We report on research related to MHK turbines at the Center for Ocean Renewable Energy (CORE) at the University of New Hampshire (UNH). The research projects span varies scales, levels of complexity and environments - from fundamental studies of hydrofoil sections in a high speed water tunnel, to moderate Reynolds number turbine tests with inflow and wake studies in a large cross-section tow tank, to deployments of highly instrumented process models at tidal energy test sites in New England. A concerted effort over the past few years has brought significant new research infrastructure for marine hydrokinetic energy conversion online at UNH-CORE. It includes: a high-speed cavitation tunnel with independent control of velocity and pressure; a highly accurate tow mechanism, turbine test bed and wake traversing system for the 3.7m x 2.4m cross-section UNH tow tank; a 10.7m x 3.0m tidal energy test platform which can accommodate turbines up to 1.5m in diameter, for deployments at the UNH-CORE Tidal Energy Test Site in Great Bay Estuary, NH, a sheltered 'nursery site' suitable for intermediate scale tidal energy conversion device testing with peak currents typically above 2 m/s during each tidal cycle. Further, a large boundary layer wind tunnel, the new UNH Flow Physics Facility (W6.0m x H2.7m xL72m) is being used for detailed turbine wake studies, producing data and insight also applicable to MHK turbines in low Froude number deployments. Bi-directional hydrofoils, which perform equally well in either flow direction and could avoid the use of complex and maintenance-intensive yaw or blade pitch mechanisms, are being investigated theoretically, numerically and experimentally. For selected candidate shapes lift, drag, wake, and cavitation inception/desinence are measured. When combined with a cavitation inception model for MHK turbines, this information can be used to prescribe turbine design/operational parameters. Experiments were performed with a 1m diameter and 1m

  5. The PASCO Wireless Smart Cart: A Game Changer in the Undergraduate Physics Laboratory

    Science.gov (United States)

    Shakur, Asif; Connor, Rainor

    2018-03-01

    With the introduction of the Wireless Smart Cart by PASCO scientific in April 2016, we expect a paradigm shift in undergraduate physics laboratory instruction. We have evaluated the feasibility of using the smart cart by carrying out experiments that are usually performed using traditional PASCO equipment. The simplicity, convenience, and cost-saving achieved by replacing a plethora of traditional laboratory sensors, wires, and equipment clutter with the smart cart are reported here.

  6. Differential expression of CART in feeding and reward circuits in binge eating rat model.

    Science.gov (United States)

    Bharne, Ashish P; Borkar, Chandrashekhar D; Subhedar, Nishikant K; Kokare, Dadasaheb M

    2015-09-15

    Binge eating (BE) disrupts feeding and subverts reward mechanism. Since cocaine- and amphetamine-regulated transcript peptide (CART) mediates satiety as well as reward, its role in BE justifies investigation. To induce BE, rats were provided restricted access to high fat sweet palatable diet (HFSPD) for a period of 4 weeks. Immunoreactivity profile of the CART elements, and accompanying neuroplastic changes were studied in satiety- and reward-regulating brain nuclei. Further, we investigated the effects of CART, CART-antibody or rimonabant on the intake of normal chow or HFSPD. Rats fed on HFSPD showed development of BE-like phenotype as reflected by significant consumption of HFSPD in short time frame, suggestive of dysregulated satiety mechanisms. At the mid-point during BE, CART-immunoreactivity was significantly increased in hypothalamic arcuate (ARC), lateral (LH), nucleus accumbens shell (AcbSh) and paraventricular nucleus of thalamus (PVT). However, for next 22-h post-binge time-period, the animals showed no interest in food, and low CART expression. Pre-binge treatment with rimonabant, a drug recommended for the treatment of BE, produced anorexia, increased CART expression in ARC and LH, but not in AcbSh and PVT. Higher dose of CART was required to produce anorexia in binged rats. While neuronal tracing studies confirmed CART fiber connectivity from ARC and LH to AcbSh, increase in CART and synaptophysin immunostaining in this pathway in BE rats suggested strengthening of the CART connectivity. We conclude that CART bearing ARC-LH-PVT-AcbSh reward circuit may override the satiety signaling in ARC-PVN pathway in BE rats. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells.

    Science.gov (United States)

    Gust, Juliane; Hay, Kevin A; Hanafi, Laïla-Aïcha; Li, Daniel; Myerson, David; Gonzalez-Cuyar, Luis F; Yeung, Cecilia; Liles, W Conrad; Wurfel, Mark; Lopez, Jose A; Chen, Junmei; Chung, Dominic; Harju-Baker, Susanna; Özpolat, Tahsin; Fink, Kathleen R; Riddell, Stanley R; Maloney, David G; Turtle, Cameron J

    2017-12-01

    Lymphodepletion chemotherapy followed by infusion of CD19-targeted chimeric antigen receptor-modified T (CAR-T) cells can be complicated by neurologic adverse events (AE) in patients with refractory B-cell malignancies. In 133 adults treated with CD19 CAR-T cells, we found that acute lymphoblastic leukemia, high CD19 + cells in bone marrow, high CAR-T cell dose, cytokine release syndrome, and preexisting neurologic comorbidities were associated with increased risk of neurologic AEs. Patients with severe neurotoxicity demonstrated evidence of endothelial activation, including disseminated intravascular coagulation, capillary leak, and increased blood-brain barrier (BBB) permeability. The permeable BBB failed to protect the cerebrospinal fluid from high concentrations of systemic cytokines, including IFNγ, which induced brain vascular pericyte stress and their secretion of endothelium-activating cytokines. Endothelial activation and multifocal vascular disruption were found in the brain of a patient with fatal neurotoxicity. Biomarkers of endothelial activation were higher before treatment in patients who subsequently developed grade ≥4 neurotoxicity. Significance: We provide a detailed clinical, radiologic, and pathologic characterization of neurotoxicity after CD19 CAR-T cells, and identify risk factors for neurotoxicity. We show endothelial dysfunction and increased BBB permeability in neurotoxicity and find that patients with evidence of endothelial activation before lymphodepletion may be at increased risk of neurotoxicity. Cancer Discov; 7(12); 1404-19. ©2017 AACR. See related commentary by Mackall and Miklos, p. 1371 This article is highlighted in the In This Issue feature, p. 1355 . ©2017 American Association for Cancer Research.

  8. Hydraulic turbines and auxiliary equipment

    Energy Technology Data Exchange (ETDEWEB)

    Luo Gaorong [Organization of the United Nations, Beijing (China). International Centre of Small Hydroelectric Power Plants

    1995-07-01

    This document presents a general overview on hydraulic turbines and auxiliary equipment, emphasizing the turbine classification, in accordance with the different types of turbines, standard turbine series in China, turbine selection based on the basic data required for the preliminary design, general hill model curves, chart of turbine series and the arrangement of application for hydraulic turbines, hydraulic turbine testing, and speed regulating device.

  9. Improving fish survival through turbines

    International Nuclear Information System (INIS)

    Ferguson, J.W.

    1993-01-01

    Much of what is known about fish passage through hydroturbines has been developed by studying migratory species of fish passing through large Kaplan turbine units. A review of the literature on previous fish passage research presented in the accompanying story illustrates that studies have focused on determining mortality levels, rather than identifying the causal mechanism involved. There is a need for understanding how turbine designs could be altered to improve fish passage conditions, how to retrofit existing units, and how proposed hydro plant operational changes may affect fish survival. The US Army Corps of Engineers has developed a research program to define biologically based engineering criteria for improving fish passage conditions. Turbine designs incorporating these criteria can be evaluated for their effects on fish survival, engineering issues, costs, and power production. The research program has the following objectives: To gain a thorough knowledge of the mechanisms of fish mortality; To define the biological sensitivities of key fish species to these mechanisms of mortality; To develop new turbine design criteria to reduce fish mortality; To construct prototype turbine designs, and to test these designs for fish passage, hydro-mechanical operation, and power production; and To identify construction and power costs associated with new turbine designs

  10. Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glands

    Directory of Open Access Journals (Sweden)

    Gunnarsdóttir Anna

    2007-07-01

    Full Text Available Abstract Background The peptide CART is widely expressed in central and peripheral neurons, as well as in endocrine cells. Known peripheral sites of expression include the gastrointestinal (GI tract, the pancreas, and the adrenal glands. In rodent pancreas CART is expressed both in islet endocrine cells and in nerve fibers, some of which innervate the islets. Recent data show that CART is a regulator of islet hormone secretion, and that CART null mutant mice have islet dysfunction. CART also effects GI motility, mainly via central routes. In addition, CART participates in the regulation of the hypothalamus-pituitary-adrenal-axis. We investigated CART expression in porcine pancreas, GI-tract, adrenal glands, and thyroid gland using immunocytochemistry. Results CART immunoreactive (IR nerve cell bodies and fibers were numerous in pancreatic and enteric ganglia. The majority of these were also VIP IR. The finding of intrinsic CART containing neurons indicates that pancreatic and GI CART IR nerve fibers have an intrinsic origin. No CART IR endocrine cells were detected in the pancreas or in the GI tract. The adrenal medulla harboured numerous CART IR endocrine cells, most of which were adrenaline producing. In addition CART IR fibers were frequently seen in the adrenal cortex and capsule. The capsule also contained CART IR nerve cell bodies. The majority of the adrenal CART IR neuronal elements were also VIP IR. CART IR was also seen in a substantial proportion of the C-cells in the thyroid gland. The majority of these cells were also somatostatin IR, and/or 5-HT IR, and/or VIP IR. Conclusion CART is a major neuropeptide in intrinsic neurons of the porcine GI-tract and pancreas, a major constituent of adrenaline producing adrenomedullary cells, and a novel peptide of the thyroid C-cells. CART is suggested to be a regulatory peptide in the porcine pancreas, GI-tract, adrenal gland and thyroid.

  11. Sensitivity of Turbine-Height Wind Speeds to Parameters in Planetary Boundary-Layer and Surface-Layer Schemes in the Weather Research and Forecasting Model

    Science.gov (United States)

    Yang, Ben; Qian, Yun; Berg, Larry K.; Ma, Po-Lun; Wharton, Sonia; Bulaevskaya, Vera; Yan, Huiping; Hou, Zhangshuan; Shaw, William J.

    2017-01-01

    We evaluate the sensitivity of simulated turbine-height wind speeds to 26 parameters within the Mellor-Yamada-Nakanishi-Niino (MYNN) planetary boundary-layer scheme and MM5 surface-layer scheme of the Weather Research and Forecasting model over an area of complex terrain. An efficient sampling algorithm and generalized linear model are used to explore the multiple-dimensional parameter space and quantify the parametric sensitivity of simulated turbine-height wind speeds. The results indicate that most of the variability in the ensemble simulations is due to parameters related to the dissipation of turbulent kinetic energy (TKE), Prandtl number, turbulent length scales, surface roughness, and the von Kármán constant. The parameter associated with the TKE dissipation rate is found to be most important, and a larger dissipation rate produces larger hub-height wind speeds. A larger Prandtl number results in smaller nighttime wind speeds. Increasing surface roughness reduces the frequencies of both extremely weak and strong airflows, implying a reduction in the variability of wind speed. All of the above parameters significantly affect the vertical profiles of wind speed and the magnitude of wind shear. The relative contributions of individual parameters are found to be dependent on both the terrain slope and atmospheric stability.

  12. Turbine stage model

    International Nuclear Information System (INIS)

    Kazantsev, A.A.

    2009-01-01

    A model of turbine stage for calculations of NPP turbine department dynamics in real time was developed. The simulation results were compared with manufacturer calculations for NPP low-speed and fast turbines. The comparison results have shown that the model is valid for real time simulation of all modes of turbines operation. The model allows calculating turbine stage parameters with 1% accuracy. It was shown that the developed turbine stage model meets the accuracy requirements if the data of turbine blades setting angles for all turbine stages are available [ru

  13. The aerodynamics of wind turbines

    DEFF Research Database (Denmark)

    Sørensen, Jens Nørkær; Mikkelsen, Robert Flemming; Troldborg, Niels

    2013-01-01

    In the paper we present state-of-the-art of research in wind turbine aerodynamics. We start be giving a brief historical review and a survey over aerodynamic research in wind energy. Next, we focus on some recent research results obtained by our wind energy group at Department of Mechanical...... Engineering at DTU. In particular, we show some new results on the classical problem of the ideal rotor and present a series of new results from an on-going research project dealing with the modelling and simulation of turbulent flow structures in the wake behind wind turbines....

  14. Achievement report for fiscal 1991. Research and development of ceramic gas turbine (Study on its adaptability with society); 1991 nendo ceramic tas turbine no kenkyu kaihatsu seika hokokusho. Shakai tekigosei kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-05-01

    With an objective to assist proliferation of ceramic gas turbine (CGT) which is desired of being put into practical use at an early time because of its effects of energy conservation and environmental preservation, discussions were given on the cogeneration system (CGS) with regard to the system design, the effect calculation and its latent markets. In Section 1, discussions were given on the energy demand characteristics in business facilities such as hotels and hospitals, and on the CGS using the CGT. Section 2 calculates effects of introducing the CGT/CGS in business facilities, Section 3 discusses the latent market quantity of the CGT/CGS for business facilities, and its social adaptability including the environmental load, Section 4 studies the CGT characteristics and the status of its development, Section 5 researches heat resistant ceramics members, and Section 6 considers the future GCT utilization fields and problems in its effective utilization. In Section 2, it was estimated that the maximum energy saving effect can reach 21% when a facility that has been operated on purchased electric power and town gas introduced a CGT/CGS system consisted mainly of an absorption type freezer and a boiler. (NEDO)

  15. DeCART v1.2 User's Manual

    International Nuclear Information System (INIS)

    Cho, J. Y.; Kim, K. S.; Kim, H. Y.; Lee, C. C.; Zee, S. Q; Joo, H. G.

    2007-07-01

    DeCART (Deterministic Core Analysis based on Ray Tracing) is a whole core neutron transport code capable of direct subpin level flux calculation at power generating conditions. It does not require a priori homogenization nor group condensation needed in conventional reactor physics calculations. The depletion and transient calculation capabilities are also available. This manual serves as a self-sufficient guide to use the code. First of all, the various features of the code are explained which encompass various modeling options as well as the basic calculation functionalities. The instructions for running the code are also given with a description of the output files generated. Next, the underlying concepts and principles of preparing a DeCART model for a problem under consideration are presented. Each part of the input needed to specify the geometry, material composition, thermal operating condition, program execution control parameters are explained with examples. The descriptions of all the input cards are then followed. Finally, various sample model inputs ranging from a simple 2D pin cell to a realistic 3D core problem, steady-state to transient problems, and from rectangular to hexagonal core problems are presented

  16. DeCART v1.1 user's manual

    International Nuclear Information System (INIS)

    Cho, J. Y.; Kim, K. S.; Kim, H. Y.; Lee, C. C.; Zee, S. Q.; Joo, H. G.

    2005-03-01

    DeCART (Deterministic Core Analysis based on Ray Tracing) is a whole core neutron transport code capable of direct subpin level flux calculation at power generating conditions. It does not require a priori homogenization nor group condensation needed in conventional reactor physics calculations. The depletion and transient calculation capabilities are also available. This manual serves as a self-sufficient guide to use the code. First of all, the various features of the code are explained which encompass various modeling options as well as the basic calculation functionalities. The instructions for running the code are also given with a description of the output files generated. Next, the underlying concepts and principles of preparing a DeCART model for a problem under consideration are presented. Each part of the input needed to specify the geometry, material composition, thermal operating condition, program execution control parameters are explained with examples. The descriptions of all the input cards are then followed. Finally, various sample model inputs ranging from a simple 2D pin cell to a realistic 3D core problem, steady-state to transient problems, are presented

  17. The PASCO Wireless Smart Cart: A Game Changer in the Undergraduate Physics Laboratory

    Science.gov (United States)

    Shakur, Asif; Connor, Rainor

    2018-01-01

    With the introduction of the Wireless Smart Cart by PASCO scientific in April 2016, we expect a paradigm shift in undergraduate physics laboratory instruction. We have evaluated the feasibility of using the smart cart by carrying out experiments that are usually performed using traditional PASCO equipment. The simplicity, convenience, and…

  18. CART peptide is a potential endogenous antioxidant and preferentially localized in mitochondria.

    Directory of Open Access Journals (Sweden)

    Peizhong Mao

    Full Text Available The multifunctional neuropeptide Cocaine and Amphetamine Regulated Transcript (CART is secreted from hypothalamus, pituitary, adrenal gland and pancreas. It also can be found in circulatory system. This feature suggests a general role for CART in different cells. In the present study, we demonstrate that CART protects mitochondrial DNA (mtDNA, cellular proteins and lipids against the oxidative action of hydrogen peroxide, a widely used oxidant. Using cis-parinaric acid as a sensitive reporting probe for peroxidation in membranes, and a lipid-soluble azo initiator of peroxyl radicals, 2,2'-azobis(2,4-dimethylvaleronitrile we found that CART is an antioxidant. Furthermore, we found that CART localized to mitochondria in cultured cells and mouse brain neuronal cells. More importantly, pretreatment with CART by systemic injection protects against a mouse oxidative stress model, which mimics the main features of Parkinson's disease. Given the unique molecular structure and biological features of CART, we conclude that CART is an antioxidant peptide (or antioxidant hormone. We further propose that it may have strong therapeutic properties for human diseases in which oxidative stress is strongly involved such as Parkinson's disease.

  19. Schoolchildren's Consumption of Competitive Foods and Beverages, Excluding a la Carte

    Science.gov (United States)

    Kakarala, Madhuri; Keast, Debra R.; Hoerr, Sharon

    2010-01-01

    Background: Competitive foods/beverages are those in school vending machines, school stores, snack bars, special sales, and items sold a la carte in the school cafeteria that compete with United States Department of Agriculture (USDA) meal program offerings. Grouping a la carte items with less nutritious items allowed in less regulated venues may…

  20. Feeding a sustainable chemical industry: do we have the bioproducts cart before the feedstocks horse?

    Science.gov (United States)

    Dale, Bruce E

    2017-09-21

    A sustainable chemical industry cannot exist at scale without both sustainable feedstocks and feedstock supply chains to provide the raw materials. However, most current research focus is on producing the sustainable chemicals and materials. Little attention is given to how and by whom sustainable feedstocks will be supplied. In effect, we have put the bioproducts cart before the sustainable feedstocks horse. For example, bulky, unstable, non-commodity feedstocks such as crop residues probably cannot supply a large-scale sustainable industry. Likewise, those who manage land to produce feedstocks must benefit significantly from feedstock production, otherwise they will not participate in this industry and it will never grow. However, given real markets that properly reward farmers, demand for sustainable bioproducts and bioenergy can drive the adoption of more sustainable agricultural and forestry practices, providing many societal "win-win" opportunities. Three case studies are presented to show how this "win-win" process might unfold.

  1. Latin American Integration: Regionalism à la Carte in a Multipolar World?

    Directory of Open Access Journals (Sweden)

    Cintia Quiliconi

    2017-10-01

    Full Text Available This article presents an analysis of the different approaches proposed by authors who have done research on Latin American integration and regionalism, and suggests that there are three competing initiatives of integration and regionalism in the third wave of Latin American integration: Post-Liberal Regionalism contained within UNASUR and ALBA, Open Regionalism Reloaded in the region through the Pacific Alliance, and Multilateralism or Diplomatic Regionalism with a Latin American flavor envisaged in the recently created CELAC. The study concludes that these new developments of a regionalism à la carte are a product of dislocation of the economic agenda of regionalism towards a set of diverse issues. Hence it demands a rethinking of the theorization of Latin American Regionalism.

  2. AZ-101 Mixer Pump Demonstration Data Acquisition System and Gamma Cart Data Acquisition Control System Software Configuration Management Plan

    International Nuclear Information System (INIS)

    WHITE, D.A.

    1999-01-01

    This Software Configuration Management Plan (SCMP) provides the instructions for change control of the AZ1101 Mixer Pump Demonstration Data Acquisition System (DAS) and the Sludge Mobilization Cart (Gamma Cart) Data Acquisition and Control System (DACS)

  3. Fiscal 1981 Sunshine Project research report. Development of hydrothermal power plant. Development of binary cycle power plant (Research on heat cycle and heat medium, materials, and heat medium turbine); 1981 nendo nessui riyo hatsuden plant no kaihatsu seika hokokusho. Binary cycle hatsuden plant no kaihatsu (netsu cycle oyobi netsubaitai no kenkyu, zairyo no kenkyu narasbini netsubaitai turbine no kenkyu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1982-03-01

    This report summarizes the final fiscal 1981 research result on components of the next 10MW class geothermal binary cycle power plant. In the research on heat cycle and heat medium, R-C318 and R-124 were excellent in output characteristics in a low-temperature zone and high-temperature zone in a hot water temperature range of 120-160 degreesC, respectively, however, at present R-114 was most reasonable from the viewpoint of heat medium price and supply system. In the research on martials, study was made on inlet-attack and stress corrosion of heat exchanger pipes of 18Cr-13Ni-2Mo steel, and combination use of inexpensive materials (carbon steel). As used giving attention to stress corrosion, at present 18Cr-13Ni-2Mo steel was most suitable material, while clad carbon steel was also usable. In the research on heat medium turbine, the 1000-hour durability test result of mechanical seal showed that mechanical seal is best for heat medium turbines. (NEDO)

  4. Fiscal 1980 Sunshine Project research report. Development of hydrothermal power plant. Development of binary cycle power plant (Research on heat cycle, heat medium, material and heat medium turbine); 1980 nendo nessui riyo hatsuden plant no kaihatsu seika hokokusho. Binary cycle hatsuden plant no kaihatsu (netsu cycle oyobi netsubaitai no kenkyu, zairyo no kenkyu narabini netsubaitai turbine no kenkyu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1981-03-01

    This report summarizes the fiscal 1980 research result on each element of the next 10MW class geothermal binary cycle power plant, following last year. In the research on heat cycle and heat medium, measurement was made on the liquid density, vapor density, liquid specific heat, vapor specific heat and thermal conductivity of 8 heat media to prepare the precise pressure enthalpy chart. The thermal stability of each medium was also measured under a flow condition. The heat cycle of each medium was calculated in a hydrothermal temperature range of 120-160 degrees C for evaluation of its output. In the research on material, field corrosion test and laboratory simulation were made on 3 kinds of heat exchanger martials for acidic hot water to study the corrosion behavior of welding members. In the research on heat medium turbine, study was made on sealing characteristics such as differential pressure, flow rate and friction of sealing oil for oil film seal and mechanical seal as shaft seal devices of heat medium turbines for the 10MW class geothermal plant. (NEDO)

  5. SMART POWER TURBINE

    Energy Technology Data Exchange (ETDEWEB)

    Nirm V. Nirmalan

    2003-11-01

    Gas turbines are the choice technology for high-performance power generation and are employed in both simple and combined cycle configurations around the world. The Smart Power Turbine (SPT) program has developed new technologies that are needed to further extend the performance and economic attractiveness of gas turbines for power generation. Today's power generation gas turbines control firing temperatures indirectly, by measuring the exhaust gas temperature and then mathematically calculating the peak combustor temperatures. But temperatures in the turbine hot gas path vary a great deal, making it difficult to control firing temperatures precisely enough to achieve optimal performance. Similarly, there is no current way to assess deterioration of turbine hot-gas-path components without shutting down the turbine. Consequently, maintenance and component replacements are often scheduled according to conservative design practices based on historical fleet-averaged data. Since fuel heating values vary with the prevalent natural gas fuel, the inability to measure heating value directly, with sufficient accuracy and timeliness, can lead to maintenance and operational decisions that are less than optimal. GE Global Research Center, under this Smart Power Turbine program, has developed a suite of novel sensors that would measure combustor flame temperature, online fuel lower heating value (LHV), and hot-gas-path component life directly. The feasibility of using the ratio of the integrated intensities of portions of the OH emission band to determine the specific average temperature of a premixed methane or natural-gas-fueled combustion flame was demonstrated. The temperature determined is the temperature of the plasma included in the field of view of the sensor. Two sensor types were investigated: the first used a low-resolution fiber optic spectrometer; the second was a SiC dual photodiode chip. Both methods worked. Sensitivity to flame temperature changes was

  6. CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells.

    Science.gov (United States)

    Zhang, Yongping; Zhang, Xingying; Cheng, Chen; Mu, Wei; Liu, Xiaojuan; Li, Na; Wei, Xiaofei; Liu, Xiang; Xia, Changqing; Wang, Haoyi

    2017-12-01

    T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advanced refractory B cell malignancy. However, many challenges remain in extending its application toward the treatment of solid tumors. The immunosuppressive nature of tumor microenvironment is considered one of the key factors limiting CAR-T efficacy. One negative regulator of Tcell activity is lymphocyte activation gene-3 (LAG-3). We successfully generated LAG-3 knockout Tand CAR-T cells with high efficiency using CRISPR-Cas9 mediated gene editing and found that the viability and immune phenotype were not dramatically changed during in vitro culture. LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity in cell culture and in murine xenograft model, which is comparable to standard CAR-T cells. Our study demonstrates an efficient approach to silence immune checkpoint in CAR-T cells via gene editing.

  7. [Current Status and Challenges of CAR-T Immunotherapy in Hematologic Malignancies -Review].

    Science.gov (United States)

    Cheng, Xin; Wang, Ya-Jie; Feng, Shuai; Wu, Ya-Yun; Yang, Tong-Hua; Lai, Xun

    2018-04-01

    The chimeric antigen receptor (CAR) T cell therapy has gradually became a new trend in the treatment of refractory and relapsed hematologic malignancies by developing for 30 years. With the exciting development of genetic engineering, CAR-T technology has subjected to 4 generations of innovation. Structure of CAR-T started from a single signal molecule to 2 or more than 2 co-stimulatory molecules, and then coding the CAR gene or promoter. CAR-T can specifically recognize tumor antigens, and does not be restricted by major histocompatibility complex (MHC), thus making a breakthrough in clinical treatment. In this review, the history, structure and mechanism of action of CAR-T, as well as the current status and challenges of CAR-T immunotherapy in acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia and multiple myeloma are summarized.

  8. FY 1998 Report on development of large-scale wind power generation systems. Research of wind turbines for storm worthy and easy construction; 1998 nendo ogata furyoku hatsuden system kaihatsu. Taikyofu kensetsu yoigata fusha ni kansuru chosa kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The research and development statuses in various countries are surveyed, to have useful information to draw the future R and D directions for wind turbines resistant to storms and easy construction. Greece has sites suitable for wind power generation in mountainous districts, and is developing the systems while taking the characteristic weather conditions into consideration. The country provides information regarding aerodynamic/structural design methods for wind turbine blades applicable to turbulent wind generated by complex terrain, and wind assessment and analyses in complex terrain. In India, on-the-spot surveys are made at the cyclone-attacked wind farms. One of the areas on which the USA is putting emphasis is development of small-size wind turbines and wind-diesel hybrid systems for developing countries and independent grid systems in remote areas. Australia is constructing wind-diesel hybrid systems to be connected to a number of independent grid systems in its western area. In Europe, information is collected for the advanced aerodynamic analysis, construction of offshore wind turbines, and production engineering and facilities for blades and other components from Vestas and N.E.G. Micon as the leading wind turbine makers. (NEDO)

  9. The impact research of control modes in steam turbine control system (digital electric hydraulic to the low-frequency oscillation of grid

    Directory of Open Access Journals (Sweden)

    Yanghai Li

    2016-01-01

    Full Text Available Through the analysis of the control theory for steam turbine, the transfer function of the steam turbine control modes in the parallel operation was obtained. The frequency domain analysis indicated that different control modes of turbine control system have different influence on the damping characteristics of the power system. The comparative analysis shows the direction and the degree of the influence under the different oscillation frequency range. This can provide the theory for the suppression of the low-frequency oscillation from turbine side and has a guiding significance for the stability of power system. The results of simulation tests are consistent with the theoretic analysis.

  10. Turbine main engines

    CERN Document Server

    Main, John B; Herbert, C W; Bennett, A J S

    1965-01-01

    Turbine Main Engines deals with the principle of operation of turbine main engines. Topics covered include practical considerations that affect turbine design and efficiency; steam turbine rotors, blades, nozzles, and diaphragms; lubricating oil systems; and gas turbines for use with nuclear reactors. Gas turbines for naval boost propulsion, merchant ship propulsion, and naval main propulsion are also considered. This book is divided into three parts and begins with an overview of the basic mode of operation of the steam turbine engine and how it converts the pressure energy of the ingoing ste

  11. Italian translation and cross-cultural comparison with the Childhood Attachment and Relational Trauma Screen (CARTS).

    Science.gov (United States)

    Simonelli, A; Sacchi, C; Cantoni, L; Brown, M; Frewen, P

    2017-01-01

    Background : The Childhood Attachment and Relational Trauma Screen (CARTS) is a computer-administered survey designed to assess retrospectively the socio-ecological context in which instances of child abuse may have occurred. To date, studies supporting the validity of the CARTS have only been undertaken in English-speaking North American populations. Validation projects in other countries and cross-cultural comparisons are therefore warranted. Objective : Develop and preliminarily evaluate the psychometric properties of an Italian version of the CARTS on college students and compare such observations to data acquired from Canadian students. Method : Seventy-nine undergraduate students from the University of Padua (Italy) completed an Italian translation of the CARTS as well as measures of childhood experiences, mental health and attachment, responses to which were compared to those obtained in 288 Canadian students who completed the CARTS in English. Results : Internal consistency and convergent validity with the Childhood Trauma Questionnaire and Parental Bonding Instrument were found to be acceptable for the Italian translation. Within the Italian sample, correlation analyses suggested that CARTS Mother ratings referring to attachment and abuse were associated with romantic attachment, whereas CARTS Father ratings were significantly correlated to PTSD symptoms and other symptoms of psychopathology-distress. Significant differences between Italian and Canadian students across the relationship types for the CARTS abuse and attachment scales were found, indicating that Italian students rated their mothers and fathers as simultaneously less abusive, but also less as a source of secure attachment. Conclusions : The results of this preliminary study seem to suggest convergent validity of the Italian CARTS and the association between childhood attachment-related experiences and romantic attachment. Cultural variations were identified between Canadian and Italian

  12. Studies of super-critical CO2 gas turbine power generation fast reactor (Contract research, translated document)

    International Nuclear Information System (INIS)

    Kisohara, Naoyuki; Kotake, Shoji; Sakamoto, Toshihiko

    2008-08-01

    The following studies have been executed for a super-critical CO 2 turbine system of an SFR. (1) Preliminary design of a SFR adopting a super-critical CO 2 cycle turbine. Preliminary system design of an SFR that adopts a super-critical CO 2 cycle turbine has been made. This SFR system eliminates secondary sodium circuits because of no sodium/water reaction. The power generation efficiency of the SFR has been estimated to be approximately 42%. Compared to a conventional SFR that adopts a steam Rankine cycle with secondary sodium circuits, the volume of the reactor building of the SC-CO 2 SFR has been reduced by 20%. (2) Thermal-hydraulic experiment of a super-critical CO 2 cycle loop. A test loop that simulates a super-critical CO 2 whole cycle was fabricated. An electrical heater was used for a heat source of the test loop. The high efficiency of the compressor has been experimentally confirmed near the super-critical region. The temperature efficiencies of PCHE recuperators have been approximately 98-99% (hot leg), and the recuperators have exhibited high heat transfer performance. No significant flow instability has been observed in the test loop operation. (3) Liquid sodium/CO 2 reaction test. Reaction tests have been executed by contacting a small amount of liquid sodium and CO 2 gas. Continuous sodium/CO 2 reactions with flame have occurred at the temperature higher than 570-580degC. Main reaction products have been Na 2 CO 3 and CO gas. The reaction heat has been also measured to be 50-75kJ/Na-mol. (4) Computer code safety analysis for tube failure of sodium/CO 2 heat exchanger. Safety calculation has been done for one double ended guillotine tube failure (1 DEG) of a helical coil type sodium/CO 2 heat exchanger. The analysis has showed that the maximum pressure in the primary sodium circuit is 0.28MPa due to a gas leak. It has been, however, below the allowed level of the primary circuit structural integrity. The void reactivity of the reactor core has

  13. Turbine system and adapter

    Science.gov (United States)

    Hogberg, Nicholas Alvin; Garcia-Crespo, Andres Jose

    2017-05-30

    A turbine system and adapter are disclosed. The adapter includes a turbine attachment portion having a first geometry arranged to receive a corresponding geometry of a wheelpost of a turbine rotor, and a bucket attachment portion having a second geometry arranged to receive a corresponding geometry of a root portion of a non-metallic turbine bucket. Another adapter includes a turbine attachment portion arranged to receive a plurality of wheelposts of a turbine rotor, and a bucket attachment portion arranged to receive a plurality of non-metallic turbine buckets having single dovetail configuration root portions. The turbine system includes a turbine rotor wheel configured to receive metal buckets, at least one adapter secured to at least one wheelpost on the turbine rotor wheel, and at least one non-metallic bucket secured to the at least one adapter.

  14. Advanced Wind Turbine Drivetrain Concepts. Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2010-12-01

    This report presents key findings from the Department of Energy’s Advanced Drivetrain Workshop, held on June 29-30, 2010, to assess different advanced drivetrain technologies, their relative potential to improve the state-of-the-art in wind turbine drivetrains, and the scope of research and development needed for their commercialization in wind turbine applications.

  15. Association of Cocaine- and Amphetamine-Regulated Transcript (CART) Messenger RNA Level, Food Intake, and Growth in Channel Catfish

    Science.gov (United States)

    Cocaine-and Amphetamine-Regulated Transcript (CART) is a potent hypothalamic anorectic peptide in mammals and fish. We hypothesized that increased food intake is associated with changes in expression of CART mRNA within the brain of channel catfish. Objectives were to clone the CART gene, examine ...

  16. Purification and characterisation of a new hypothalamic satiety peptide, cocaine and amphetamine regulated transcript (CART), produced in yeast.

    Science.gov (United States)

    Thim, L; Nielsen, P F; Judge, M E; Andersen, A S; Diers, I; Egel-Mitani, M; Hastrup, S

    1998-05-29

    Cocaine and amphetamine regulated transcript (CART) is a newly discovered hypothalamic peptide with a potent appetite suppressing activity following intracerebroventricular administration. When the mature rat CART sequence encoding CART(1-102) was inserted in the yeast expression plasmid three CART peptides could be purified from the fermentation broth reflecting processing at dibasic sequences. None of these corresponded to the naturally occurring CART(55-102). In order to obtain CART(55-102) the precursor Glu-Glu-Ile-Asp-CART(55-102) has been produced and CART(55-102) was generated by digestion of the precursor with dipeptidylaminopeptidase-1. All four generated CART peptides have been characterised by N-terminal amino acid sequencing and mass spectrometry. The CART peptides contain six cysteine residues and using the yeast expressed CART(62-102) the disulphide bond configuration was found to be I-III, II-V and IV-VI. When the four CART peptides were intracerebroventricularly injected in fasted mice (0.1 to 2.0 microg) they all produced a dose dependent inhibition of food intake.

  17. HIGH EFFICIENCY TURBINE

    OpenAIRE

    VARMA, VIJAYA KRUSHNA

    2012-01-01

    Varma designed ultra modern and high efficiency turbines which can use gas, steam or fuels as feed to produce electricity or mechanical work for wide range of usages and applications in industries or at work sites. Varma turbine engines can be used in all types of vehicles. These turbines can also be used in aircraft, ships, battle tanks, dredgers, mining equipment, earth moving machines etc, Salient features of Varma Turbines. 1. Varma turbines are simple in design, easy to manufac...

  18. Turbine maintenance and modernization

    Energy Technology Data Exchange (ETDEWEB)

    Unga, E. [Teollisuuden Voima Oy, Olkiluoto (Finland)

    1998-12-31

    The disturbance-free operation of the turbine plant plays an important role in reaching good production results. In the turbine maintenance of the Olkiluoto nuclear power plant the lifetime and efficiency of turbine components and the lifetime costs are taken into account in determining the turbine maintenance and modernization/improvement program. The turbine maintenance program and improvement/modernization measures taken in the plant units are described in this presentation. (orig.)

  19. Turbine maintenance and modernization

    Energy Technology Data Exchange (ETDEWEB)

    Unga, E [Teollisuuden Voima Oy, Olkiluoto (Finland)

    1999-12-31

    The disturbance-free operation of the turbine plant plays an important role in reaching good production results. In the turbine maintenance of the Olkiluoto nuclear power plant the lifetime and efficiency of turbine components and the lifetime costs are taken into account in determining the turbine maintenance and modernization/improvement program. The turbine maintenance program and improvement/modernization measures taken in the plant units are described in this presentation. (orig.)

  20. Research and development of asymmetrical heat transfer augmentation method in radial channels of blades for high temperature gas turbines

    Science.gov (United States)

    Shevchenko, I. V.; Rogalev, A. N.; Garanin, I. V.; Vegera, A. N.; Kindra, V. O.

    2017-11-01

    The serpentine-like one and half-pass cooling channel systems are primarily used in blades fabricated by the lost-wax casting process. The heat transfer turbulators like cross-sectional or angled ribs used in channels of the midchord region failed to eliminate the temperature irregularity from the suction and pressure sides, which is reaching 200°C for a first stage blade of the high-pressure turbine for an aircraft engine. This paper presents the results of a numerical and experimental test of an advanced heat transfer augmentation system in radial channels developed for alignment of the temperature field from the suction and pressure sides. A numerical simulation of three-dimensional coolant flow for a wide range of Reynolds numbers was carried out using ANSYS CFX software. Effect of geometrical parameters on the heat removal asymmetry was determined. The test results of a blade with the proposed intensification system conducted in a liquid-metal thermostat confirmed the accuracy of calculations. Based on the experimental data, the dependencies for calculation of heat transfer coefficients to the cooling air in the blade studied were obtained.

  1. The gas turbine - a bundle of energy - requires tender care

    Energy Technology Data Exchange (ETDEWEB)

    Saarinen, J.; Uronen, J.; Leisio, C. [ed.

    1997-11-01

    The ability of a power plant to generate energy economically depends to a great extent on the functioning of the turbine. These days, an increasingly large number of these power plant `motors` are gas turbines. IVO`s expertise in the operation, maintenance and repair of gas turbines is based on long practical experience and the company`s own research. And IVO is also no stranger to the design and construction of new gas turbine plants

  2. Studi Eksperimental Perancangan Turbin Air Terapung Tipe Helical Blade

    OpenAIRE

    Muhammad, Andi Haris; Had, Abdul Latief; Terti, Wayan

    2016-01-01

    This research describes the design of floating helical water turbine for electric power generation in free flow and low head water operation. The design involves the use of strips attached to the blades of turbine. The efficiency of turbine (??) investigation was carried out using empirical formulas. The rotation of turbine (n) of the calculation with variation strips angles (450, 900, and 1350) were obtained through captive model tests carried out in towing tank. The result indicated the eff...

  3. "Fish Friendly" Hydropower Turbine Development and Deployment. Alden Turbine Preliminary Engineering and Model Testing

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, D. [Electric Power Research Institute, Palo Alto, CA (United States)

    2011-10-01

    This report presents the results of a collaborative research project funded by the Electric Power Research Institute (EPRI), the U.S. Department of Energy (DOE), and hydropower industry partners with the objective of completing the remaining developmental engineering required for a “fish-friendly” hydropower turbine called the Alden turbine.

  4. Differential expression of CART in ewes with differing ovulation rates.

    Science.gov (United States)

    Juengel, Jennifer L; French, Michelle C; Quirke, Laurel D; Kauff, Alexia; Smith, George W; Johnstone, Peter D

    2017-04-01

    We hypothesised that cocaine- and amphetamine-regulated transcript ( CARTPT ) would be differentially expressed in ewes with differing ovulation rates. Expression of mRNA for CARTPT , as well as LHCGR , FSHR , CYP19A1 and CYP17A1 was determined in antral follicles ≥1 mm in diameter collected during the follicular phase in ewes heterozygous for the Booroola and Inverdale genes (I+B+; average ovulation rate 4) and ++ contemporaries (++; average ovulation rate 1.8). In ++ ewes ( n  = 6), CARTPT was expressed in small follicles (1 to ewes. In I+B+ ewes, 5/6 ewes did not have any follicles that expressed CARTPT , and no CART peptide was detected in any follicle examined. Expression pattern of CYP19A1 differed between I+B+ and ++ ewes with an increased percentage of small and medium follicles (3 to ewes. Many of the large follicles from the I+B+ ewes appeared non-functional and expression of LHCGR , FSHR , CYP17A1 and CYP19A1 was less than that observed in ++ ewes. Expression of FSHR and CYP17A1 was not different between groups in small and medium follicles, but LHCGR expression was approximately double in I+B+ ewes compared to that in ++ ewes. Thus, ewes with high ovulation rates had a distinct pattern of expression of CARTPT mRNA and protein compared to ewes with normal ovulation rates, providing evidence for CART being important in the regulation of ovulation rate. © 2017 Society for Reproduction and Fertility.

  5. Wind turbine aerodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, D.A. [Waterloo Univ., ON (Canada). Dept. of Mechanical Engineering, Wind Energy Group

    2010-07-01

    The need for clean, renewable electricity in remote communities of Canada and the world was discussed in this presentation. The University of Waterloo Wind Energy Laboratory (WEL) performs research in a large scale indoor environment on wind turbines, blade aerodynamics, and aeroacoustics. A key area of research involves developing turbines for remote off-grid communities where climatic conditions are challenging. This presentation outlined research that is underway on wind energy and off-grid renewable energy systems. Many communities in Canada and remote communities in the rest of the world are not connected to the grid and are dependent on other means to supply electrical energy to their community. Remote communities in northern Canada have no road access and diesel is the dominant source of electrical energy for these communities. All of the community supply of diesel comes from brief winter road access or by air. The presentation discussed existing diesel systems and the solution of developing local renewable energy sources such as wind, hydro, biomass, geothermal, and solar power. Research goals, wind energy activities, experimental equipment, and the results were also presented. Research projects have been developed in wind energy; hydrogen generation/storage/utilization; power electronics/microgrid; and community engagement. figs.

  6. Integration of an Inter Turbine Burner to a Jet Turbine Engine

    Science.gov (United States)

    2013-03-01

    Technology AFRL = Air Force Research Laboratory EGV = Exit Guide Vane HPT = High-Pressure Turbine ID = Inner Diameter IGV = Inlet Guide Vane...been able to show computationally that the compressor exit guide vane (EGV) and the turbine inlet guide vane ( IGV ) could be combined into a single...turbine engine hot section. The red slashed out sections are, from left to right, the compressor exit vane, HPT IGV , and the stator between the HPT and

  7. Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy.

    Science.gov (United States)

    Golubovskaya, Vita; Wu, Lijun

    2016-03-15

    This review is focused on different subsets of T cells: CD4 and CD8, memory and effector functions, and their role in CAR-T therapy--a cellular adoptive immunotherapy with T cells expressing chimeric antigen receptor. The CAR-T cells recognize tumor antigens and induce cytotoxic activities against tumor cells. Recently, differences in T cell functions and the role of memory and effector T cells were shown to be important in CAR-T cell immunotherapy. The CD4⁺ subsets (Th1, Th2, Th9, Th17, Th22, Treg, and Tfh) and CD8⁺ memory and effector subsets differ in extra-cellular (CD25, CD45RO, CD45RA, CCR-7, L-Selectin [CD62L], etc.); intracellular markers (FOXP3); epigenetic and genetic programs; and metabolic pathways (catabolic or anabolic); and these differences can be modulated to improve CAR-T therapy. In addition, CD4⁺ Treg cells suppress the efficacy of CAR-T cell therapy, and different approaches to overcome this suppression are discussed in this review. Thus, next-generation CAR-T immunotherapy can be improved, based on our knowledge of T cell subsets functions, differentiation, proliferation, and signaling pathways to generate more active CAR-T cells against tumors.

  8. Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy

    Directory of Open Access Journals (Sweden)

    Vita Golubovskaya

    2016-03-01

    Full Text Available This review is focused on different subsets of T cells: CD4 and CD8, memory and effector functions, and their role in CAR-T therapy––a cellular adoptive immunotherapy with T cells expressing chimeric antigen receptor. The CAR-T cells recognize tumor antigens and induce cytotoxic activities against tumor cells. Recently, differences in T cell functions and the role of memory and effector T cells were shown to be important in CAR-T cell immunotherapy. The CD4+ subsets (Th1, Th2, Th9, Th17, Th22, Treg, and Tfh and CD8+ memory and effector subsets differ in extra-cellular (CD25, CD45RO, CD45RA, CCR-7, L-Selectin [CD62L], etc.; intracellular markers (FOXP3; epigenetic and genetic programs; and metabolic pathways (catabolic or anabolic; and these differences can be modulated to improve CAR-T therapy. In addition, CD4+ Treg cells suppress the efficacy of CAR-T cell therapy, and different approaches to overcome this suppression are discussed in this review. Thus, next-generation CAR-T immunotherapy can be improved, based on our knowledge of T cell subsets functions, differentiation, proliferation, and signaling pathways to generate more active CAR-T cells against tumors.

  9. New analogs of the CART peptide with anorexigenic potency: the importance of individual disulfide bridges.

    Science.gov (United States)

    Blechová, Miroslava; Nagelová, Veronika; Záková, Lenka; Demianová, Zuzana; Zelezná, Blanka; Maletínská, Lenka

    2013-01-01

    The CART (cocaine- and amphetamine-regulated transcript) peptide is an anorexigenic neuropeptide that acts in the hypothalamus. The receptor and the mechanism of action of this peptide are still unknown. In our previous study, we showed that the CART peptide binds specifically to PC12 rat pheochromocytoma cells in both the native and differentiated into neuronal phenotype. Two biologically active forms, CART(55-102) and CART(61-102), with equal biological activity, contain three disulfide bridges. To clarify the importance of each of these disulfide bridges in maintaining the biological activity of CART(61-102), an Ala scan at particular S-S bridges forming cysteines was performed, and analogs with only one or two disulfide bridges were synthesized. In this study, a stabilized CART(61-102) analog with norleucine instead of methionine at position 67 was also prepared and was found to bind to PC12 cells with an anorexigenic potency similar to that of CART(61-102). The binding study revealed that out of all analogs tested, [Ala(68,86)]CART(61-102), which contains two disulfide bridges (positions 74-94 and 88-101), preserved a high affinity to both native PC12 cells and those that had been differentiated into neurons. In food intake and behavioral tests with mice after intracerebroventricular administration, this analog showed strong and long-lasting anorexigenic potency. Therefore, the disulfide bridge between cysteines 68 and 86 in CART(61-102) can be omitted without a loss of biological activity, but the preservation of two other disulfide bridges and the full-length peptide are essential for biological activity. Copyright © 2012 Elsevier Inc. All rights reserved.

  10. Myeloid Conditioning with c-kit-Targeted CAR-T Cells Enables Donor Stem Cell Engraftment.

    Science.gov (United States)

    Arai, Yasuyuki; Choi, Uimook; Corsino, Cristina I; Koontz, Sherry M; Tajima, Masaki; Sweeney, Colin L; Black, Mary A; Feldman, Steven A; Dinauer, Mary C; Malech, Harry L

    2018-05-02

    We report a novel approach to bone marrow (BM) conditioning using c-kit-targeted chimeric antigen receptor T (c-kit CAR-T) cells in mice. Previous reports using anti-c-kit or anti-CD45 antibody linked to a toxin such as saporin have been promising. We developed a distinctly different approach using c-kit CAR-T cells. Initial studies demonstrated in vitro killing of hematopoietic stem cells by c-kit CAR-T cells but poor expansion in vivo and poor migration of CAR-T cells into BM. Pre-treatment of recipient mice with low-dose cyclophosphamide (125 mg/kg) together with CXCR4 transduction in the CAR-T cells enhanced trafficking to and expansion in BM (c-kit + population (9.0%-0.1%). Because congenic Thy1.1 CAR-T cells were used in the Thy1.2-recipient mice, anti-Thy1.1 antibody could be used to deplete CAR-T cells in vivo before donor BM transplant. This achieved 20%-40% multilineage engraftment. We applied this conditioning to achieve an average of 28% correction of chronic granulomatous disease mice by wild-type BM transplant. Our findings provide a proof of concept that c-kit CAR-T cells can achieve effective BM conditioning without chemo-/radiotherapy. Our work also demonstrates that co-expression of a trafficking receptor can enhance targeting of CAR-T cells to a designated tissue. Published by Elsevier Inc.

  11. Efisiensi Prototipe Turbin Savonius pada Kecepatan Angin Rendah

    Directory of Open Access Journals (Sweden)

    Melda Latif

    2013-04-01

    Full Text Available Wind energy can be transformed into electrical energy using wind turbine. Based on rotation axis, there are two types of wind turbine, namely turbine with horizontal axis and the one with vertical axis. Turbine with vertical axis has been known with various names that are Darrieus turbine, Savonius turbine and H turbine. This research designed and implemented a prototype of simple Savonius turbine for small scale wind speed. Resistor with resistance of 200 ohm and LED are used as the load. Material of the prototype is alumunium plate, which is light and easy to find. The experiment was conducted at the beach. Permanent magnet synchronous generator was chosen for generating equipment. Voltage resulted by the generator increased as the wind speed increased. The prototype began rotating at wind speed 2.4 m/s. Average efficiency for Y and D connected load are 4.8% and 14.5% respectively.

  12. Grid integration impacts on wind turbine design and development

    DEFF Research Database (Denmark)

    Hansen, Anca Daniela; Cutululis, Nicolaos Antonio; Sørensen, Poul Ejnar

    2009-01-01

    This paper presents an overall perspective on contemporary issues like wind power plants and grid integration. The purpose is to present and discuss the impacts of emerging new grid connection requirements on modern wind turbines. The grid integration issue has caused several new challenges......, the grid integration aspect has also an effect on wind turbines' role in the power system, on wind turbine technologies' survival on the market, as well as on the wind turbines' loads. Over the last years, it became obviously, that there it is an increasing need for design and research of wind turbines...... to the wind turbine design and development. The survival of different wind turbine concepts and controls is strongly conditioned by their ability to comply with stringent grid connection requirements, imposed by utility companies. Beside its impact on the mechanical design and control of wind turbines...

  13. STS-37 crewmembers test CETA hand cart during training session in JSC's WETF

    Science.gov (United States)

    1989-01-01

    STS-37 Atlantis, Orbiter Vehicle (OV) 104, Mission Specialist (MS) Jerry L. Ross and MS Jerome Apt test crew and equipment translation aid (CETA) manual hand over hand cart during underwater session in JSC's Weightless Environment Training Facility (WETF) Bldg 29. Wearing an extravehicular mobility unit (EMU), Ross pulls the CETA manual cart along the rail while Apt holds onto the back of the cart. The test will determine how difficult it is to maneuver cargo in such a manner when it is done in space on STS-37. The goal is to find the best method for astronauts to move around the exterior of Space Station Freedom (SSF).

  14. Steam turbine cycle

    International Nuclear Information System (INIS)

    Okuzumi, Naoaki.

    1994-01-01

    In a steam turbine cycle, steams exhausted from the turbine are extracted, and they are connected to a steam sucking pipe of a steam injector, and a discharge pipe of the steam injector is connected to an inlet of a water turbine. High pressure discharge water is obtained from low pressure steams by utilizing a pressurizing performance of the steam injector and the water turbine is rotated by the high pressure water to generate electric power. This recover and reutilize discharged heat of the steam turbine effectively, thereby enabling to improve heat efficiency of the steam turbine cycle. (T.M.)

  15. The swirl turbine

    Science.gov (United States)

    Haluza, M.; Pochylý, F.; Rudolf, P.

    2012-11-01

    In the article is introduced the new type of the turbine - swirl turbine. This turbine is based on opposite principle than Kaplan turbine. Euler equation is satisfied in the form gHηh = -u2vu2. From this equation is seen, that inflow of liquid into the runner is without rotation and on the outflow is a rotation of liquid opposite of rotation of runner. This turbine is suitable for small head and large discharge. Some constructional variants of this turbine are introduced in the article and theoretical aspects regarding losses in the draft tube. The theory is followed by computational simulations in Fluent and experiments using laser Doppler anemometry.

  16. Failure analysis of turbine blades

    International Nuclear Information System (INIS)

    Iorio, A.F.; Crespi, J.C.

    1989-01-01

    Two 20 MW gas turbines suffered damage in blades belonging to the 2nd. stage of the turbine after 24,000 hours of duty. From research it arises that the fuel used is not quite adequate to guarantee the blade's operating life due to the excess of SO 3 , C and Na existing in combustion gases which cause pitting to the former. Later, the corrosion phenomenon is presented under tension produced by working stress enhanced by pitting where Pb is its main agent. A change of fuel is recommended thus considering the blades will reach the operational life they were designed for. (Author) [es

  17. A Hybrid PCA-CART-MARS-Based Prognostic Approach of the Remaining Useful Life for Aircraft Engines

    Directory of Open Access Journals (Sweden)

    Fernando Sánchez Lasheras

    2015-03-01

    Full Text Available Prognostics is an engineering discipline that predicts the future health of a system. In this research work, a data-driven approach for prognostics is proposed. Indeed, the present paper describes a data-driven hybrid model for the successful prediction of the remaining useful life of aircraft engines. The approach combines the multivariate adaptive regression splines (MARS technique with the principal component analysis (PCA, dendrograms and classification and regression trees (CARTs. Elements extracted from sensor signals are used to train this hybrid model, representing different levels of health for aircraft engines. In this way, this hybrid algorithm is used to predict the trends of these elements. Based on this fitting, one can determine the future health state of a system and estimate its remaining useful life (RUL with accuracy. To evaluate the proposed approach, a test was carried out using aircraft engine signals collected from physical sensors (temperature, pressure, speed, fuel flow, etc.. Simulation results show that the PCA-CART-MARS-based approach can forecast faults long before they occur and can predict the RUL. The proposed hybrid model presents as its main advantage the fact that it does not require information about the previous operation states of the input variables of the engine. The performance of this model was compared with those obtained by other benchmark models (multivariate linear regression and artificial neural networks also applied in recent years for the modeling of remaining useful life. Therefore, the PCA-CART-MARS-based approach is very promising in the field of prognostics of the RUL for aircraft engines.

  18. Heat Transfer in Gas Turbines

    Science.gov (United States)

    Garg, Vijay K.

    2001-01-01

    The turbine gas path is a very complex flow field. This is due to a variety of flow and heat transfer phenomena encountered in turbine passages. This manuscript provides an overview of the current work in this field at the NASA Glenn Research Center. Also, based on the author's preference, more emphasis is on the computational work. There is much more experimental work in progress at GRC than that reported here. While much has been achieved, more needs to be done in terms of validating the predictions against experimental data. More experimental data, especially on film cooled and rough turbine blades, are required for code validation. Also, the combined film cooling and internal cooling flow computation for a real blade is yet to be performed. While most computational work to date has assumed steady state conditions, the flow is clearly unsteady due to the presence of wakes. All this points to a long road ahead. However, we are well on course.

  19. Reliability Modeling of Wind Turbines

    DEFF Research Database (Denmark)

    Kostandyan, Erik

    Cost reductions for offshore wind turbines are a substantial requirement in order to make offshore wind energy more competitive compared to other energy supply methods. During the 20 – 25 years of wind turbines useful life, Operation & Maintenance costs are typically estimated to be a quarter...... for Operation & Maintenance planning. Concentrating efforts on development of such models, this research is focused on reliability modeling of Wind Turbine critical subsystems (especially the power converter system). For reliability assessment of these components, structural reliability methods are applied...... to one third of the total cost of energy. Reduction of Operation & Maintenance costs will result in significant cost savings and result in cheaper electricity production. Operation & Maintenance processes mainly involve actions related to replacements or repair. Identifying the right times when...

  20. Achievement report on research and development in the Sunshine Project in fiscal 1976. Comprehensive discussion on hydrogen utilizing subsystems and research on peripheral technologies (Research related to hydrogen gas turbines); 1976 nendo suiso riyo subsystem no sogoteki kento to shuhen gijutsu ni kansuru kenkyu. Suiso gas turbine ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1977-03-01

    This paper describes development of hydrogen gas turbines from among the comprehensive discussions on hydrogen utilizing subsystems. Hydrogen and oxygen gas turbine cycle has varying optimal conditions of plant efficiency depending on fuel patterns. The regenerative cycle may have the turbine inlet temperature at about 1,000 degrees C. The inlet pressure would be ten and odds atmospheric pressure. It is better to keep the inlet temperature higher in order to obtain high specific power. Reduction of power generation cost in using this plant requires that construction cost be decreased, and the specific power be increased if the plant efficiency (in other words, running cost) is assumed constant. Further development is required on technologies to use higher temperatures and pressures. For that purpose, discussions should be given on material development, structural design, and inspection. Hydrogen gas turbines, which present low pollution depending on combustion methods, have great significance for such social problem as environmental contamination. In terms of economy, since hydrogen gas turbines depend on efficiency and fuel unit cost, the evaluation thereon may vary depending on how well the regenerative gas turbines have been established, in addition to future change in hydrogen price and the technologies to use higher temperatures and pressures. (NEDO)

  1. 垂直轴风力发电机叶片气动性能研究%The research of the vertical-axis wind turbine blade's aerodynamic performance

    Institute of Scientific and Technical Information of China (English)

    戴湘晖; 徐海波

    2011-01-01

    性能优越的垂直轴风力发电机正越来越受到关注.优良的风叶是使垂直风力发电机获得最大风能利用系数和良好经济效益的基础.垂直风力发电机叶型的气动性能研究是当前叶片设计的重要内容.利用ANSYS FLUENT12.0对NACA4412、FX76MPl2、DU86-137-25以及C型四种不同叶片的气动性能进行了仿真和分析,得出C型叶片相对其他三种叶片有着更好的气动性能,能为垂直风力发电机叶片的设计起到指导作用.%Now researchers of many countries are paying more and more attention to the vertical-axis wind turbine for its superexcellent perfrmance. Excellent wind turbine blade is the foundation to get the most wind power coefficient and economic efficiency of the vertical-axis wind turbine. Research the aerodynamic performance of the vertical-axis wind turbine blade is the important content of the blade design at present. Use ANSYS FLUENT12.0 to simulate and analysis the aerodynamic performance of four different kinds of blades such as NACA4412,FX76MP12,DU86-137-25 and C,and conclude the C-shaped blade with a better aerodynamic performance compared with other three kinds of blades. The conclusion can play a guiding role in the design of the vertical-axis wind turbine blade.

  2. Aerodynamics of wind turbines

    DEFF Research Database (Denmark)

    Hansen, Martin Otto Laver

    Aerodynamics of Wind Turbines is the established essential text for the fundamental solutions to efficient wind turbine design. Now in its third edition, it has been substantially updated with respect to structural dynamics and control. The new control chapter now includes details on how to design...... Turbines (VAWT). Topics covered include increasing mass flow through the turbine, performance at low and high wind speeds, assessment of the extreme conditions under which the turbine will perform and the theory for calculating the lifetime of the turbine. The classical Blade Element Momentum method...... is also covered, as are eigenmodes and the dynamic behaviour of a turbine. The book describes the effects of the dynamics and how this can be modelled in an aeroelastic code, which is widely used in the design and verification of modern wind turbines. Furthermore, it examines how to calculate...

  3. TurbinAID

    International Nuclear Information System (INIS)

    Moradian, M.A.; Chow, M.P.; Osborne, R.L.; Jenkins, M.A.

    1991-01-01

    The Westinghouse Turbine Artificial Intelligence Diagnostics system or TurbinAID, can diagnose both thermodynamic and mechanical component anomalies within the turbine, and around the turbine cycle. any monitoring system can detect that a variable is in an abnormal state, but TurbinAID can also indicate the cause, and provide recommended corrective action(s). The TurbinAID Expert Systems utilize multiple sensor and variable inputs, and their interdependencies in the generation of a diagnosis. The system performs sensor validation as part of the data acquisition scheme. The TurbinAID system has been in operation for several years. This paper describes the monitoring and diagnostic functions provided by TurbinAID, and how the utility industry both nuclear and fossil, can utilize the system to enhance unit operation

  4. The Communities Advancing Resilience Toolkit (CART): an intervention to build community resilience to disasters.

    Science.gov (United States)

    Pfefferbaum, Rose L; Pfefferbaum, Betty; Van Horn, Richard L; Klomp, Richard W; Norris, Fran H; Reissman, Dori B

    2013-01-01

    Community resilience has emerged as a construct to support and foster healthy individual, family, and community adaptation to mass casualty incidents. The Communities Advancing Resilience Toolkit (CART) is a publicly available theory-based and evidence-informed community intervention designed to enhance community resilience by bringing stakeholders together to address community issues in a process that includes assessment, feedback, planning, and action. Tools include a field-tested community resilience survey and other assessment and analytical instruments. The CART process encourages public engagement in problem solving and the development and use of local assets to address community needs. CART recognizes 4 interrelated domains that contribute to community resilience: connection and caring, resources, transformative potential, and disaster management. The primary value of CART is its contribution to community participation, communication, self-awareness, cooperation, and critical reflection and its ability to stimulate analysis, collaboration, skill building, resource sharing, and purposeful action.

  5. Shopper marketing nutrition interventions: Social norms on grocery carts increase produce spending without increasing shopper budgets

    Directory of Open Access Journals (Sweden)

    Collin R. Payne

    2015-01-01

    Conclusions: Descriptive and provincial social norm messages (i.e., on grocery cart placards may be an overlooked tool to increase produce demand without decreasing store profitability and increasing shopper budgets.

  6. Strategies from a nationwide health information technology implementation: the VA CART story.

    Science.gov (United States)

    Box, Tamára L; McDonell, Mary; Helfrich, Christian D; Jesse, Robert L; Fihn, Stephan D; Rumsfeld, John S

    2010-01-01

    The VA Cardiovascular Assessment, Reporting, and Tracking (CART) system is a customized electronic medical record system which provides standardized report generation for cardiac catheterization procedures, serves as a national data repository, and is the centerpiece of a national quality improvement program. Like many health information technology projects, CART implementation did not proceed without some barriers and resistance. We describe the nationwide implementation of CART at the 77 VA hospitals which perform cardiac catheterizations in three phases: (1) strategic collaborations; (2) installation; and (3) adoption. Throughout implementation, success required a careful balance of technical, clinical, and organizational factors. We offer strategies developed through CART implementation which are broadly applicable to technology projects aimed at improving the quality, reliability, and efficiency of health care.

  7. Parallelization characteristics of a three-dimensional whole-core code DeCART

    International Nuclear Information System (INIS)

    Cho, J. Y.; Joo, H.K.; Kim, H. Y.; Lee, J. C.; Jang, M. H.

    2003-01-01

    Neutron transport calculation for three-dimensional amount of computing time but also huge memory. Therefore, whole-core codes such as DeCART need both also parallel computation and distributed memory capabilities. This paper is to implement such parallel capabilities based on MPI grouping and memory distribution on the DeCART code, and then to evaluate the performance by solving the C5G7 three-dimensional benchmark and a simplified three-dimensional SMART core problem. In C5G7 problem with 24 CPUs, a speedup of maximum 22 is obtained on IBM regatta machine and 21 on a LINUX cluster for the MOC kernel, which indicates good parallel performance of the DeCART code. The simplified SMART problem which need about 11 GBytes memory with one processors requires about 940 MBytes, which means that the DeCART code can now solve large core problems on affordable LINUX clusters

  8. FY 1998 annual report on the research and development of advanced ceramic gas turbines. Study on social adaptability; 1998 nendo senshingata ceramic gas turbine no kenkyu kaihatsu seika hokokusho. Shakai tekigosei kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The New Sunshine Project, promoted by Ministry of International Trade and Industry, has developed a 300 kW ceramic gas turbine CGT302 (biaxial, regenerative type) in March 1999, which attains a turbine inlet temperature of 1,334 degrees C and thermal efficiency of 42.1%. The conditions of optimum utilization of the system are studied for eventual commercialization and spread of these systems, including analysis of load types for specific purposes, prediction of operation management, economics of CGT, environmental impacts, and possibility of diversification of the fuel. The CGT cost analysis results indicate that a CGT system is well viable when the incremental initial cost of the power generator is kept below 70,000 yen/kW over the conventional system. The system can be doubled in scale at the largest. It can be further scaled up, when hybrid members with metallic materials are used. CGT is a basic technique for (system energy). In other words, the 21st. century will be the age of (system energy), i.e., (gas turbine). (NEDO)

  9. Turbulence and wind turbines

    DEFF Research Database (Denmark)

    Brand, Arno J.; Peinke, Joachim; Mann, Jakob

    2011-01-01

    The nature of turbulent flow towards, near and behind a wind turbine, the effect of turbulence on the electricity production and the mechanical loading of individual and clustered wind turbines, and some future issues are discussed.......The nature of turbulent flow towards, near and behind a wind turbine, the effect of turbulence on the electricity production and the mechanical loading of individual and clustered wind turbines, and some future issues are discussed....

  10. Probability and containment of turbine missiles

    International Nuclear Information System (INIS)

    Yeh, G.C.K.

    1976-01-01

    With the trend toward ever larger power generating plants with large high-speed turbines, an important plant design consideration is the potential for and consequences of mechanical failure of turbine rotors. Such rotor failure could result in high-velocity disc fragments (turbine missiles) perforating the turbine casing and jeopardizing vital plant systems. The designer must first estimate the probability of any turbine missile damaging any safety-related plant component for his turbine and his plant arrangement. If the probability is not low enough to be acceptable to the regulatory agency, he must design a shield to contain the postulated turbine missiles. Alternatively, the shield could be designed to retard (to reduce the velocity of) the missiles such that they would not damage any vital plant system. In this paper, some of the presently available references that can be used to evaluate the probability, containment and retardation of turbine missiles are reviewed; various alternative methods are compared; and subjects for future research are recommended. (Auth.)

  11. The Simulation Study of Horizontal Axis Water Turbine Using Flow Simulation Solidworks Application

    Science.gov (United States)

    Prasetyo, H.; Budiana, EP; Tjahjana, DDDP; Hadi, S.

    2018-02-01

    The design of Horizontal Axis Water Turbine in pico hydro power plants involves many parameters. To simplify that, usually using computer simulation is applied. This research performs simulation process variation on turbine blade number, turbine blade curvature angle, turbine bucket angle and blocking system tilt angle. Those four variations were combined in order to obtain the best design of turbine. The study used Flow Simulation Solidworks application, and obtain data on turbine speed, pressure, force, and torque. However, this research focused on turbine torque value. The best design of turbine was obtained in the turbine with 6 blades, blade curvature angle of 65° and bucket angle of 10°, and blocking system tilt angle of 40°. In the best turbine, the produced torque value was 8.464 Nm.

  12. 风机转动速度调节的PID优化算法研究%Research on PID Optimization Algorithm for Rotating Speed Regulation of Wind Turbine

    Institute of Scientific and Technical Information of China (English)

    李家伟

    2015-01-01

    With control optimizing of the rotational speed of the wind turbine, improve the output power and the power trans-mission efficiency of the wind turbine, the interference of magnetic loss coupling by the wind turbine rotor blade in the con-trol, it is difficult to achieve effective speed regulation, The algorithm has the defects of nonlinear distortion. A wind turbine of PID based on optimal control of rotating speed adjustment optimization, analysis of rotating speed adjusting parameter model of wind turbine, the wind turbine rotor blade speed adjustment control optimization objective function, the design of three layers PID neural network, the PID variable structure control, wind turbine speed shaft connected with the rotor axis the gear box, the aerodynamic excitation brake operation, speed regulation, effectively restrain the interference of wind tur-bine rotor blade control strong coupling magnetic loss, improve the speed of rotation to adjust the output control perfor-mance of wind turbine. The simulation results show that, the method can effectively realize the wind turbine speed control, it can improve the wind turbine efficiency and output gain.%通过对风机转动速度的优化控制调节,提高风机的输出功率和电能传输效率,风机转子叶片控制中受到强耦合的磁损耗的干扰,难以实现有效的转速调节,提出一种基于PID优化控制的风机转动速度调节优化算法,分析风机转动速度调节控制参数模型,构建风机转子叶片速度调节的优化控制目标函数,设计三层前向PID神经网络,通过PID变结构控制,风机的低速轴将转子轴心与齿轮箱连接,激发空气动力闸的运行,进行转速调节,有效地抑制了风机转子叶片控制中强耦合磁损耗的干扰,提高了风机转动速度调节输出控制性能.仿真结果表明,采用该方法能有效实现风机转速调节控制,提高风机运行效率和输出增益.

  13. Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA+ Metastatic Colorectal Cancers.

    Science.gov (United States)

    Zhang, Chengcheng; Wang, Zhe; Yang, Zhi; Wang, Meiling; Li, Shiqi; Li, Yunyan; Zhang, Rui; Xiong, Zhouxing; Wei, Zhihao; Shen, Junjie; Luo, Yongli; Zhang, Qianzhen; Liu, Limei; Qin, Hong; Liu, Wei; Wu, Feng; Chen, Wei; Pan, Feng; Zhang, Xianquan; Bie, Ping; Liang, Houjie; Pecher, Gabriele; Qian, Cheng

    2017-05-03

    Chimeric antigen receptor T (CAR-T) cells have shown promising efficacy in treatment of hematological malignancies, but its applications in solid tumors need further exploration. In this study, we investigated CAR-T therapy targeting carcino-embryonic antigen (CEA)-positive colorectal cancer (CRC) patients with metastases to evaluate its safety and efficacy. Five escalating dose levels (DLs) (1 × 10 5 to 1 × 10 8 /CAR + /kg cells) of CAR-T were applied in 10 CRC patients. Our data showed that severe adverse events related to CAR-T therapy were not observed. Of the 10 patients, 7 patients who experienced progressive disease (PD) in previous treatments had stable disease after CAR-T therapy. Two patients remained with stable disease for more than 30 weeks, and two patients showed tumor shrinkage by positron emission tomography (PET)/computed tomography (CT) and MRI analysis, respectively. Decline of serum CEA level was apparent in most patients even in long-term observation. Furthermore, we observed persistence of CAR-T cells in peripheral blood of patients receiving high doses of CAR-T therapy. Importantly, we observed CAR-T cell proliferation especially in patients after a second CAR-T therapy. Taken together, we demonstrated that CEA CAR-T cell therapy was well tolerated in CEA + CRC patients even in high doses, and some efficacy was observed in most of the treated patients. Copyright © 2017 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.

  14. Anthelmintic Resistance of Strongyle Nematodes to Ivermectin and Fenbendazole on Cart Horses in Gondar, Northwest Ethiopia

    OpenAIRE

    Seyoum, Zewdu; Zewdu, Alemu; Dagnachew, Shimelis; Bogale, Basazinew

    2017-01-01

    A study was conducted from November 2015 to April 2016 to determine fenbendazole and ivermectin resistance status of intestinal nematodes of cart horses in Gondar, Northwest Ethiopia. Forty-five strongyle infected animals were used for this study. The animals were randomly allocated into three groups (15 horses per group). Group I was treated with fenbendazole and Group II with ivermectin and Group III was left untreated. Faecal samples were collected from each cart horse before and after tre...

  15. An Overview of Prognosis Health Management Research at Glenn Research Center for Gas Turbine Engine Structures With Special Emphasis on Deformation and Damage Modeling

    Science.gov (United States)

    Arnold, Steven M.; Goldberg, Robert K.; Lerch, Bradley A.; Saleeb, Atef F.

    2009-01-01

    Herein a general, multimechanism, physics-based viscoelastoplastic model is presented in the context of an integrated diagnosis and prognosis methodology which is proposed for structural health monitoring, with particular applicability to gas turbine engine structures. In this methodology, diagnostics and prognostics will be linked through state awareness variable(s). Key technologies which comprise the proposed integrated approach include (1) diagnostic/detection methodology, (2) prognosis/lifing methodology, (3) diagnostic/prognosis linkage, (4) experimental validation, and (5) material data information management system. A specific prognosis lifing methodology, experimental characterization and validation and data information management are the focal point of current activities being pursued within this integrated approach. The prognostic lifing methodology is based on an advanced multimechanism viscoelastoplastic model which accounts for both stiffness and/or strength reduction damage variables. Methods to characterize both the reversible and irreversible portions of the model are discussed. Once the multiscale model is validated the intent is to link it to appropriate diagnostic methods to provide a full-featured structural health monitoring system.

  16. Robust, Gain-Scheduled Control of Wind Turbines

    DEFF Research Database (Denmark)

    Østergaard, Kasper Zinck

    Wind turbines are today large and efficient machines, which are combined into wind farms operating on par with conventional power plants. When looking back, this is significantly different from the status only a few years ago, when wind turbines were sold mainly to private people. This change...... in turbine owners has resulted in a new focus on operational reliability instead of turbine size. This research deals with investigating model-based gain-scheduling control of wind turbines by use of linear parameter varying (LPV) methods. The numerical challenges grow quickly with the model size...

  17. A reference pelton turbine - design and efficiency measurements

    OpenAIRE

    Solemslie, Bjørn Winther; Dahlhaug, Ole Gunnar

    2014-01-01

    The Pelton turbine has been subject to a varying degree of research interest since the debut of the technology over a century ago. Despite its age there are gaps in the knowledge concerning the flow mechanisms effecting the flow through the turbine. A Pelton turbine has been designed at the Waterpower Laboratory at NTNU. This has been done in connection to a Ph.D. project focusing on the flow in Pelton turbine buckets. The design of the turbine has been conducted using in-house knowledge in a...

  18. Technology of turbine plant operating with wet steam

    International Nuclear Information System (INIS)

    1989-01-01

    The technology of turbine plant operating with wet steam is a subject of continuing interest and importance, notably in view of the widespread use of wet steam cycles in nuclear power plants and the recent developments of advanced low pressure blading for both conventional and wet steam turbines. The nature of water formation in expanding steam has an important influence on the efficiency of turbine blading and on the integrity and safe operating life of blading and associated turbine and plant components. The subjects covered in this book include research, flow analysis and measurement, development and design of turbines and ancillary plant, selection of materials of construction, manufacturing methods and operating experience. (author)

  19. Sliding vane geometry turbines

    Science.gov (United States)

    Sun, Harold Huimin; Zhang, Jizhong; Hu, Liangjun; Hanna, Dave R

    2014-12-30

    Various systems and methods are described for a variable geometry turbine. In one example, a turbine nozzle comprises a central axis and a nozzle vane. The nozzle vane includes a stationary vane and a sliding vane. The sliding vane is positioned to slide in a direction substantially tangent to an inner circumference of the turbine nozzle and in contact with the stationary vane.

  20. Evaluation of solar-assisted, electric and gas golf carts, Bathurst Glen golf course, Richmond Hill, Ontario

    International Nuclear Information System (INIS)

    2010-08-01

    Municipalities try to limit air pollution resulting from the use of small gasoline engines. Indeed, these engines participate in the smog and greenhouse gas (GHG) emissions and they present operating costs more important than electric equivalents. The potential positive impacts of the use of electric or solar electric golf carts instead of gasoline carts are analyzed through a study that compares two solar-assisted electric golf carts, two standard electric golf carts and two gas-powered golf carts. The energy use and related Co2 emissions, the dependability, and the relative costs were evaluated and Golfer preference was also considered thanks to a feedback survey. The comparison between the solar-assisted and the standard electric carts was made on the basis of electricity measures at three points: alternating current (AC) electricity taken from the grid, direct current (DC) electricity flowing into and out of the batteries, and DC electricity generated by the solar panels. The data collected during this study suggested that other factors associated with cart condition or driver behaviours can be more important than the solar panels in determining overall energy consumption. Choosing an area with full sun exposure to install the solar panel and connecting directly to the grid would also maximize generation potential. The comparison of performance between electric carts and gas carts showed the most considerable positive findings. Indeed, fuel costs and emissions are significantly lower in the case of the electric carts, which also present a better fuel efficiency. Switching the 20 percent of gas-powered carts counted within a 100 km radius of Toronto with electric carts could be comparable to removing 155 mid-sized gasoline cars of the road. The electric golf carts present many important financial and environmental benefits when compared to gas carts. The performance is marginally enhanced with the use of solar panels on electric carts and the date collected from

  1. CAR-T Cells: A Systematic Review and Mixed Methods Analysis of the Clinical Trial Landscape.

    Science.gov (United States)

    Pettitt, David; Arshad, Zeeshaan; Smith, James; Stanic, Tijana; Holländer, Georg; Brindley, David

    2018-02-07

    CAR-T cells are a promising new therapy that offer significant advantages compared with conventional immunotherapies. This systematic review and clinical trial landscape identifies and critiques published CAR-T cell clinical trials and examines the critical factors required to enable CAR-T cells to become a standard therapy. A review of the literature was conducted to identify suitable studies from the MEDLINE and Ovid bibliographic databases. The literature and database searches identified 20 studies for inclusion. The average number of participants per clinical trial examined was 11 patients. All studies included in this systematic review investigated CAR-T cells and were prospective, uncontrolled clinical studies. Leukemia is the most common cancer subtype and accounts for 57.4% (n = 120) of disease indications. The majority of studies used an autologous cell source (85%, n = 17) rather than an allogeneic cell source. Translational challenges encompass technical considerations relating to CAR-T cell development, manufacturing practicability, clinical trial approaches, CAR-T cell quality and persistence, and patient management. Copyright © 2017 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.

  2. Cocaine-and Amphetamine Regulated Transcript (CART) Peptide Is Expressed in Precursor Cells and Somatotropes of the Mouse Pituitary Gland

    Science.gov (United States)

    Mortensen, Amanda H.

    2016-01-01

    Cocaine-and Amphetamine Regulated Transcript (CART) peptide is expressed in the brain, endocrine and neuroendocrine systems and secreted into the serum. It is thought to play a role in regulation of hypothalamic pituitary functions. Here we report a spatial and temporal analysis of Cart expression in the pituitaries of adult and developing normal and mutant mice with hypopituitarism. We found that Prop1 is not necessary for initiation of Cart expression in the fetal pituitary at e14.5, but it is required indirectly for maintenance of Cart expression in the postnatal anterior pituitary gland. Pou1f1 deficiency has no effect on Cart expression before or after birth. There is no 1:1 correspondence between CART and any particular cell type. In neonates, CART is detected primarily in non-proliferating, POU1F1-positive cells. CART is also found in some cells that express TSH and GH suggesting a correspondence with committed progenitors of the POU1F1 lineage. In summary, we have characterized the normal temporal and cell specific expression of CART in mouse development and demonstrate that postnatal CART expression in the pituitary gland requires PROP1. PMID:27685990

  3. Cocaine-and Amphetamine Regulated Transcript (CART Peptide Is Expressed in Precursor Cells and Somatotropes of the Mouse Pituitary Gland.

    Directory of Open Access Journals (Sweden)

    Amanda H Mortensen

    Full Text Available Cocaine-and Amphetamine Regulated Transcript (CART peptide is expressed in the brain, endocrine and neuroendocrine systems and secreted into the serum. It is thought to play a role in regulation of hypothalamic pituitary functions. Here we report a spatial and temporal analysis of Cart expression in the pituitaries of adult and developing normal and mutant mice with hypopituitarism. We found that Prop1 is not necessary for initiation of Cart expression in the fetal pituitary at e14.5, but it is required indirectly for maintenance of Cart expression in the postnatal anterior pituitary gland. Pou1f1 deficiency has no effect on Cart expression before or after birth. There is no 1:1 correspondence between CART and any particular cell type. In neonates, CART is detected primarily in non-proliferating, POU1F1-positive cells. CART is also found in some cells that express TSH and GH suggesting a correspondence with committed progenitors of the POU1F1 lineage. In summary, we have characterized the normal temporal and cell specific expression of CART in mouse development and demonstrate that postnatal CART expression in the pituitary gland requires PROP1.

  4. Intermediate transport in Southeast Asia. [Carts, cycles, mini-buses

    Energy Technology Data Exchange (ETDEWEB)

    Meier, A.K.

    1977-06-01

    Traffic flows through the streets of Southeast Asian countries even though they are used for almost all aspects of human and animal existence. The carts, bicycles, tricycles, and motorcycles, motorized three-wheelers, mini-buses are the so-called intermediate-transport vehicles. It is upon this group of vehicles that a culture--constrained by its own unique economic, environmental, and technological factors--exerts its influence most directly toward the solution of the transport problem. Transportation fills more service roles in Southeast Asian cities than in Western cities. Communication facilities such as telephones and postal services are notoriously unreliable. The personal encounter is all important in social and business interactions in Southeast Asia. Each of the transport modes is examined in view of design and use in a number of specific cultural settings for the countries in Southeast Asia. Present use of intermediate transport in developed countries is discussed briefly, and its further development predicted--pointing out the health and conservation advantages. (MCW)

  5. Motion sickness in ancient China: Seasickness and cart-sickness.

    Science.gov (United States)

    Brandt, Thomas; Bauer, Matthias; Benson, Judy; Huppert, Doreen

    2016-07-19

    To find and analyze descriptions of motion sickness in Chinese historical sources. Databases and dictionaries were searched for various terms for seasickness and travel sickness, which were then entered into databases of full texts allowing selection of relevant passages from about the third to the 19th century ad. Already in 300 ad the Chinese differentiated cart-sickness, particularly experienced by persons from the arid north of China, from a ship-illness experienced by persons from the south, where rivers were important for transportation and travel. In the Middle Ages, a third form of motion sickness was called litter-influence experienced by persons transported in a bed suspended between 2 long poles. The ancient Chinese recognized the particular susceptibility of children to motion sickness. Therapeutic recommendations include drinking the urine of young boys, swallowing white sand-syrup, collecting water drops from a bamboo stick, or hiding some earth from the middle of the kitchen hearth under the hair. The Chinese medical classics distinguished several forms of travel sickness, all of which had their own written characters. The pathophysiologic mechanism was explained by the medicine of correspondences, which was based on malfunctions within the body, its invasion by external pathogens like wind, or the deficit or surfeit of certain bodily substances such as the life force Qi. The concept of motion as the trigger of sickness initially appeared in a chapter on warding off the influence of demons and corpses, e.g., ancient magic and beliefs. © 2016 American Academy of Neurology.

  6. Multidisciplinary approach to converting power chair into motorized prone cart.

    Science.gov (United States)

    Brose, Steven W; Wali, Eisha

    2014-01-01

    Pressure ulcers remain a major source of morbidity and mortality in veterans with neurologic impairment. Management of pressure ulcers typically involves pressure relief over skin regions containing wounds, but this can lead to loss of mobility and independence when the wounds are located in regions that receive pressure from sitting. An innovative, low-cost, multidisciplinary effort was undertaken to maximize quality of life in a veteran with a thoracic-4 level complete spinal cord injury and a stage 4 ischial wound. The person's power wheelchair was converted into a motorized prone cart, allowing navigation of the Department of Veterans Affairs spinal cord injury hospital ward and improved socialization while relieving pressure on the wound. Physical and occupational therapy assisted with the reconfiguration of the power chair and verified safe transfers into the chair and driving of the device. Psychology verified positive psychosocial benefit, while nursing and physician services verified an absence of unwanted pain or skin injury resulting from use of the device. Further investigation of ways to apply this technique is warranted to improve the quality of life of persons with pressure ulcers.

  7. To Love—To Live: Barrow and Cart

    Directory of Open Access Journals (Sweden)

    Lisa McDonald

    2013-02-01

    Full Text Available From the residue of meaning, an ensemble of shadows. From the glint of souvenir, pliable impressions. In this paper, we work a poetics of encounter, of being, keeping, homage, of paying homage to fragility, to object and to interspecies—ways are found to engage motion from within and around co-extensive bodies. With the consolation of images, we follow the terse rhythms of routine and street where dwelling is a case of affective dissent. Zones of departure appear through testimony as well as chance, taking their own form. A footfall brings us as observers into quiet spaces which refuse self-estrangement as we travel by way of an unquiet ground. Breath, respiration, aspiration. Precipitation. Sculptures of mist are also the language of lives, of kinship between object, footfall and air. A language of brackets, questions, ellipses. There may be a man, a dog, a barrow. There may be a woman, a cart. Air. How shall this image be made?

  8. Demographic and financial characteristics of school districts with low and high à la Carte sales in rural Kansas Public Schools.

    Science.gov (United States)

    Nollen, Nicole L; Kimminau, Kim S; Nazir, Niaman

    2011-06-01

    Reducing à la carte items in schools-foods and beverages sold outside the reimbursable meals program-can have important implications for childhood obesity. However, schools are reluctant to reduce à la carte offerings because of the impact these changes could have on revenue. Some foodservice programs operate with limited à la carte sales, but little is known about these programs. This secondary data analysis compared rural and urban/suburban school districts with low and high à la carte sales. Foodservice financial records (2007-2008) were obtained from the Kansas State Department of Education for all public K-12 school districts (n=302). χ² and t tests were used to examine the independent association of variables to à la carte sales. A multivariate model was then constructed of the factors most strongly associated with low à la carte sales. In rural districts with low à la carte sales, lunch prices and participation were higher, lunch costs and à la carte quality were lower, and fewer free/reduced price lunches were served compared to rural districts with high à la carte sales. Lunch price (odds ratio=1.2; 95% confidence interval, 1.1 to 1.4) and free/reduced price lunch participation (odds ratio=3.0; 95% confidence interval, 1.0 to 9.8) remained in the multivariate model predicting low à la carte sales. No differences were found between urban/suburban districts with low and high à la carte sales. Findings highlight important factors to maintaining low à la carte sales. Schools should consider raising lunch prices and increasing meal participation rates as two potential strategies for reducing the sale of à la carte items without compromising foodservice revenue. Copyright © 2011 American Dietetic Association. Published by Elsevier Inc. All rights reserved.

  9. Numerical simulation of turbulence flow in a Kaplan turbine -Evaluation on turbine performance prediction accuracy-

    Science.gov (United States)

    Ko, P.; Kurosawa, S.

    2014-03-01

    The understanding and accurate prediction of the flow behaviour related to cavitation and pressure fluctuation in a Kaplan turbine are important to the design work enhancing the turbine performance including the elongation of the operation life span and the improvement of turbine efficiency. In this paper, high accuracy turbine and cavitation performance prediction method based on entire flow passage for a Kaplan turbine is presented and evaluated. Two-phase flow field is predicted by solving Reynolds-Averaged Navier-Stokes equations expressed by volume of fluid method tracking the free surface and combined with Reynolds Stress model. The growth and collapse of cavitation bubbles are modelled by the modified Rayleigh-Plesset equation. The prediction accuracy is evaluated by comparing with the model test results of Ns 400 Kaplan model turbine. As a result that the experimentally measured data including turbine efficiency, cavitation performance, and pressure fluctuation are accurately predicted. Furthermore, the cavitation occurrence on the runner blade surface and the influence to the hydraulic loss of the flow passage are discussed. Evaluated prediction method for the turbine flow and performance is introduced to facilitate the future design and research works on Kaplan type turbine.

  10. Numerical simulation of turbulence flow in a Kaplan turbine -Evaluation on turbine performance prediction accuracy-

    International Nuclear Information System (INIS)

    Ko, P; Kurosawa, S

    2014-01-01

    The understanding and accurate prediction of the flow behaviour related to cavitation and pressure fluctuation in a Kaplan turbine are important to the design work enhancing the turbine performance including the elongation of the operation life span and the improvement of turbine efficiency. In this paper, high accuracy turbine and cavitation performance prediction method based on entire flow passage for a Kaplan turbine is presented and evaluated. Two-phase flow field is predicted by solving Reynolds-Averaged Navier-Stokes equations expressed by volume of fluid method tracking the free surface and combined with Reynolds Stress model. The growth and collapse of cavitation bubbles are modelled by the modified Rayleigh-Plesset equation. The prediction accuracy is evaluated by comparing with the model test results of Ns 400 Kaplan model turbine. As a result that the experimentally measured data including turbine efficiency, cavitation performance, and pressure fluctuation are accurately predicted. Furthermore, the cavitation occurrence on the runner blade surface and the influence to the hydraulic loss of the flow passage are discussed. Evaluated prediction method for the turbine flow and performance is introduced to facilitate the future design and research works on Kaplan type turbine

  11. Turbine Imaging Technology Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Moursund, Russell A.; Carlson, Thomas J.

    2004-12-31

    The goal of this project was to identify and evaluate imaging alternatives for observing the behavior of juvenile fish within an operating Kaplan turbine unit with a focus on methods to quantify fish injury mechanisms inside an operating turbine unit. Imaging methods are particularly needed to observe the approach and interaction of fish with turbine structural elements. This evaluation documents both the opportunities and constraints for observing juvenile fish at specific locations during turbine passage. The information may be used to acquire the scientific knowledge to make structural improvements and create opportunities for industry to modify turbines and improve fish passage conditions.

  12. Turbine related fish mortality

    International Nuclear Information System (INIS)

    Eicher, G.J.

    1993-01-01

    A literature review was conducted to assess the factors affecting turbine-related fish mortality. The mechanics of fish passage through a turbine is outlined, and various turbine related stresses are described, including pressure and shear effects, hydraulic head, turbine efficiency, and tailwater level. The methodologies used in determining the effects of fish passage are evaluated. The necessity of adequate controls in each test is noted. It is concluded that mortality is the result of several factors such as hardiness of study fish, fish size, concentrations of dissolved gases, and amounts of cavitation. Comparisons between Francis and Kaplan turbines indicate little difference in percent mortality. 27 refs., 5 figs

  13. Turbine Imaging Technology Assessment

    International Nuclear Information System (INIS)

    Moursund, Russell A.; Carlson, Thomas J.

    2004-01-01

    The goal of this project was to identify and evaluate imaging alternatives for observing the behavior of juvenile fish within an operating Kaplan turbine unit with a focus on methods to quantify fish injury mechanisms inside an operating turbine unit. Imaging methods are particularly needed to observe the approach and interaction of fish with turbine structural elements. This evaluation documents both the opportunities and constraints for observing juvenile fish at specific locations during turbine passage. The information may be used to acquire the scientific knowledge to make structural improvements and create opportunities for industry to modify turbines and improve fish passage conditions

  14. Design Load Basis for Offshore Wind turbines

    DEFF Research Database (Denmark)

    Natarajan, Anand; Hansen, Morten Hartvig; Wang, Shaofeng

    2016-01-01

    DTU Wind Energy is not designing and manufacturing wind turbines and does therefore not need a Design Load Basis (DLB) that is accepted by a certification body. However, to assess the load consequences of innovative features and devices added to existing offshore turbine concepts or new offshore...... turbine concept developed in our research, it is useful to have a full DLB that follows the current design standard and is representative of a general DLB used by the industry. It will set a standard for the offshore wind turbine design load evaluations performed at DTU Wind Energy, which is aligned...... with the challenges faced by the industry and therefore ensures that our research continues to have a strong foundation in this interaction. Furthermore, the use of a full DLB that follows the current standard can improve and increase the feedback from the research at DTU Wind Energy to the international...

  15. NEXT GENERATION TURBINE PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    William H. Day

    2002-05-03

    The Next Generation Turbine (NGT) Program's technological development focused on a study of the feasibility of turbine systems greater than 30 MW that offer improvement over the 1999 state-of-the-art systems. This program targeted goals of 50 percent turndown ratios, 15 percent reduction in generation cost/kW hour, improved service life, reduced emissions, 400 starts/year with 10 minutes to full load, and multiple fuel usage. Improvement in reliability, availability, and maintainability (RAM), while reducing operations, maintenance, and capital costs by 15 percent, was pursued. This program builds on the extensive low emissions stationary gas turbine work being carried out by Pratt & Whitney (P&W) for P&W Power Systems (PWPS), which is a company under the auspices of the United Technologies Corporation (UTC). This study was part of the overall Department of Energy (DOE) NGT Program that extends out to the year 2008. A follow-on plan for further full-scale component hardware testing is conceptualized for years 2002 through 2008 to insure a smooth and efficient transition to the marketplace for advanced turbine design and cycle technology. This program teamed the National Energy Technology Laboratory (NETL), P&W, United Technologies Research Center (UTRC), kraftWork Systems Inc., a subcontractor on-site at UTRC, and Multiphase Power and Processing Technologies (MPPT), an off-site subcontractor. Under the auspices of the NGT Program, a series of analyses were performed to identify the NGT engine system's ability to serve multiple uses. The majority were in conjunction with a coal-fired plant, or used coal as the system fuel. Identified also was the ability of the NGT system to serve as the basis of an advanced performance cycle: the humid air turbine (HAT) cycle. The HAT cycle is also used with coal gasification in an integrated cycle HAT (IGHAT). The NGT systems identified were: (1) Feedwater heating retrofit to an existing coal-fired steam plant, which

  16. Micro-turbines

    International Nuclear Information System (INIS)

    Tashevski, Done

    2003-01-01

    In this paper a principle of micro-turbines operation, type of micro-turbines and their characteristics is presented. It is shown their usage in cogeneration and three generation application with the characteristics, the influence of more factors on micro-turbines operation as well as the possibility for application in Macedonia. The paper is result of the author's participation in the training program 'Micro-turbine technology' in Florida, USA. The characteristics of different types micro-turbines by several world producers are shown, with accent on US micro-turbines producers (Capstone, Elliott). By using the gathered Author's knowledge, contacts and the previous knowledge, conclusions and recommendations for implementation of micro-turbines in Macedonia are given. (Author)

  17. Effect of duct geometry on Wells turbine performance

    International Nuclear Information System (INIS)

    Shaaban, S.; Abdel Hafiz, A.

    2012-01-01

    Highlights: ► A Wells turbine duct design in the form of venturi duct is proposed and investigated. ► Optimum duct geometry is identified. ► Up to 14% increase of the turbine power can be achieved using the optimized duct geometry. ► Up to 9% improve of the turbine efficiency is attained by optimizing the turbine duct geometry. ► The optimized duct geometry results in tangible delay of the turbine stalling point. - Abstract: Wells turbines can represent important source of renewable energy for many countries. An essential disadvantage of Wells turbines is their low aerodynamic efficiency and consequently low power produced. In order to enhance the Wells turbine performance, the present research work proposes the use of a symmetrical duct in the form of a venturi tube with turbine rotor located at throat. The effects of duct area ratio and duct angle are investigated in order to optimize Wells turbine performance. The turbine performance is numerically investigated by solving the steady 3D incompressible Reynolds Averaged Navier–Stocks equation (RANS). A substantial improve of the turbine performance is achieved by optimizing the duct geometry. Increasing both the duct area ratio and duct angle increase the acceleration and deceleration upstream and downstream the rotor respectively. The accelerating flow with thinner boundary layer thickness upstream the rotor reduces the flow separation on the rotor suction side. The downstream diffuser reduces the interaction between tip leakage flow and blade suction side. Up to 14% increase in turbine power and 9% increase in turbine efficiency are achieved by optimizing the duct geometry. On other hand, a tangible delay of the turbine stall point is also detected.

  18. Performance characteristics of aerodynamically optimum turbines for wind energy generators

    Science.gov (United States)

    Rohrbach, C.; Worobel, R.

    1975-01-01

    This paper presents a brief discussion of the aerodynamic methodology for wind energy generator turbines, an approach to the design of aerodynamically optimum wind turbines covering a broad range of design parameters, some insight on the effect on performance of nonoptimum blade shapes which may represent lower fabrication costs, the annual wind turbine energy for a family of optimum wind turbines, and areas of needed research. On the basis of the investigation, it is concluded that optimum wind turbines show high performance over a wide range of design velocity ratios; that structural requirements impose constraints on blade geometry; that variable pitch wind turbines provide excellent power regulation and that annual energy output is insensitive to design rpm and solidity of optimum wind turbines.

  19. Effect of anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons in hypothalamic structures of C57Bl/6 mice involved in the food intake regulation

    Czech Academy of Sciences Publication Activity Database

    Pirnik, Z.; Maixnerová, Jana; Matyšková, Resha; Koutová, Darja; Železná, Blanka; Maletínská, Lenka; Kiss, A.

    2010-01-01

    Roč. 31, č. 1 (2010), s. 139-144 ISSN 0196-9781 R&D Projects: GA ČR GA303/05/0614 Institutional research plan: CEZ:AV0Z40550506 Keywords : cholecystokinin * CART * hypocretin * Fos peptide Subject RIV: CE - Biochemistry Impact factor: 2.654, year: 2010

  20. CART (cocaine- and amphetamine-regulated transcript) peptide specific binding sites in PC12 cells have characteristics of CART peptide receptors

    Czech Academy of Sciences Publication Activity Database

    Nagelová, Veronika; Pirnik, Z.; Železná, Blanka; Maletínská, Lenka

    2014-01-01

    Roč. 1547, Feb 14 (2014), s. 16-24 ISSN 0006-8993 R&D Projects: GA ČR GAP303/10/1368 Institutional support: RVO:61388963 Keywords : CART peptide * PC12 cell * differentiation * binding * signaling * c-Jun Subject RIV: CE - Biochemistry Impact factor: 2.843, year: 2014

  1. Aircraft gas turbines

    Energy Technology Data Exchange (ETDEWEB)

    Arai, M [Kawasaki Heavy Industries Ltd., Kobe (Japan)

    1995-03-01

    Recently the international relationship has been playing an important role in the research, development and production of the aircraft gas turbine. The YSX, which is supposed to be the 100-seat class commercial aircraft, has been planned by Japan Aircraft Development (JADC) as an international cooperative project. Recently many western aeroengine companies have offered the collaboration of small turbofan engines which would be installed on YSX to Japanese aeroengine companies (IHI, KHI and MHI). The YSX is powered by 16,000-20,000 1bs thrust class engines. As for medium turbofan engine (V2500), the V 2500 family of 22,000 to 30,000 1bs thrust has been developed since 1983 through international collaboration by seven aeroengine companies in five nations. In this paper, the recent Japan`s activities of the research, development and production with viewing the world-wide movement, are described. 6 figs.

  2. Data Driven Modelling of the Dynamic Wake Between Two Wind Turbines

    DEFF Research Database (Denmark)

    Knudsen, Torben; Bak, Thomas

    2012-01-01

    turbine. This paper establishes flow models relating the wind speeds at turbines in a farm. So far, research in this area has been mainly based on first principles static models and the data driven modelling done has not included the loading of the upwind turbine and its impact on the wind speed downwind......Wind turbines in a wind farm, influence each other through the wind flow. Downwind turbines are in the wake of upwind turbines and the wind speed experienced at downwind turbines is hence a function of the wind speeds at upwind turbines but also the momentum extracted from the wind by the upwind....... This paper is the first where modern commercial mega watt turbines are used for data driven modelling including the upwind turbine loading by changing power reference. Obtaining the necessary data is difficult and data is therefore limited. A simple dynamic extension to the Jensen wake model is tested...

  3. The design of wind turbine for electrical power generation in Malaysian wind characteristics

    International Nuclear Information System (INIS)

    Abas Ab Wahab; Chong Wen Thong

    2000-01-01

    The paper describes the study of a wind turbine for electrical power generation in Malaysia wind characteristics. In this research, the wind turbine is designs based on the local wind characteristics and tries to avoid the problems faced in the past (turbine design, access, manpower and technical). The new wind turbine rotor design for a medium speed wind speed turbine utilises the concept of open-close type of horizontal axis (up-wind) wind turbine is intended to widen the optimum performance range for electrical generation in Malaysia wind characteristics. The wind turbine has been designed to cut-in at a lower speed, and to provide the rotation speed that high enough to run a generator. The analysis and design of new low speed wind turbine blades and open-close turbine rotor and prediction of turbine performance are being detailed in this paper. (Author)

  4. Wind turbines - generating noise or electricity?

    International Nuclear Information System (INIS)

    Russell, Eric

    1999-01-01

    Wind turbine technology has made great strides in the past few years. Annual energy output is up by two orders of magnitude and nacelle weight and noise has been halved. Computational fluid dynamics has paid a part in advancing knowledge of air flow and turbulence around wind generators. Current research is focused on how to increase turbine size and improve efficiency. A problem is that while larger wind turbines will produce cheaper electricity, the noise problem will mean that the number of acceptable sites will decrease. The biggest wind generators will need about 800 m clearance from the nearest house. (UK)

  5. Advanced technology for aero gas turbine components

    Energy Technology Data Exchange (ETDEWEB)

    1987-09-01

    The Symposium is aimed at highlighting the development of advanced components for new aero gas turbine propulsion systems in order to provide engineers and scientists with a forum to discuss recent progress in these technologies and to identify requirements for future research. Axial flow compressors, the operation of gas turbine engines in dust laden atmospheres, turbine engine design, blade cooling, unsteady gas flow through the stator and rotor of a turbomachine, gear systems for advanced turboprops, transonic blade design and the development of a plenum chamber burner system for an advanced VTOL engine are among the topics discussed.

  6. CAR-T cells and allogeneic hematopoietic stem cell transplantation for relapsed/refractory B-cell acute lymphoblastic leukemia.

    Science.gov (United States)

    Liu, Jun; Zhang, Xi; Zhong, Jiang F; Zhang, Cheng

    2017-10-01

    Relapsed/refractory acute lymphoblastic leukemia (ALL) has a low remission rate after chemotherapy, a high relapse rate and poor long-term survival even when allogeneic hematopoietic stem cell transplantation (allo-HSCT) is performed. Chimeric antigen receptors redirected T cells (CAR-T cells) can enhance disease remission with a favorable outcome for relapsed/refractory ALL, though some cases quickly relapsed after CAR-T cell treatment. Thus, treatment with CAR-T cells followed by allo-HSCT may be the best way to treat relapsed/refractory ALL. In this review, we first discuss the different types of CAR-T cells. We then discuss the treatment of relapsed/refractory ALL using only CAR-T cells. Finally, we discuss the use of CAR-T cells, followed by allo-HSCT, for the treatment of relapsed/refractory ALL.

  7. Report on achievements in fiscal 1999. Technology for a closed type high-efficiency gas turbine handling recovery of carbon dioxide (Research and development in the first term); 1999 nendo nisanka tanso kaishu taio closed gata kokoritsu gas turbine gijutsu daiikki kenkyu kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Research and development has been made on a gas turbine that can separate and recover carbon dioxide without discharging nitrogen oxides by means of oxygen combustion of natural gas (methane). This paper summarizes the achievements in fiscal 1999. The system discussions included those on accuracy of a performance analyzing program, sensitivity analysis, and a possibility of constructing a closed verification device in case of using the existing gas turbines. In developing the combustion control technology, design, trial fabrication, and combustion tests were carried out on combustion nozzles. As a result, it was discovered that achieving the combustion efficiency of 98% or higher is possible as the development target for the time being. In developing the turbine blade cooling technology, two-dimensional analysis was performed on heat fluidity between blades by using the low Reynolds k-{epsilon} method, wherein relatively good agreement with measurement results was obtained. In developing major auxiliary devices, a high-pressure compressor was designed, and candidate materials for a condenser and a heat exchanger were tested. In developing ultra high temperature materials, an oxidation test was performed on the undercoat for TBC, and a steam oxidation test on TMS-75. (NEDO)

  8. Marketing research with respect to centralized electric power generation with wind turbines. Verkenning van de markt voor centrale elektriciteitsopwekking met windenergie

    Energy Technology Data Exchange (ETDEWEB)

    Lenstra, W.J.; Van den Doel, J.C.

    1985-01-01

    The electric utilities so far are not eager to invest in wind power as long as the price per kWh wind power is higher than saved fuel costs. The price the electric utilities are willing to pay for surplus wind power still remains low. Combined with price expectations in the near future for fossil fuels the market does not show great prospects. Wind turbine manufacturers were asked about price-quantity curves of wind turbine types: 3 MW, 1 MW, and 300 kW respectively. Combining the demand and supply side of the market it seems possible in areas having a good wind regime to exploit wind power in a cost-effective way. For a market incentive a wind power capacity of 400 MW: 75-3 MW wind turbines, 120-1 MW wind turbines, 15-300 kW wind turbines and 50 MW for demonstration projects for proving the viability of the technology. 3 figs., 2 tabs.

  9. 241-AZ-101 Mixer Pump Demonstration Test Gamma Cart Acceptance Test Procedure and Quality Test Plan (ATP and QTP)

    International Nuclear Information System (INIS)

    WHITE, D.A.

    2000-01-01

    Shop test of the sludge mobilization cart system to be used in the AZ-101 Mixer Pump Demonstration Test Tests hardware and software. This procedure involves testing the Instrumentation involved with the Gamma Cart System, local and remote, including depth indicators, speed controls, interface to data acquisition software and the raising and lowering functions. This Procedure will be performed twice, once for each Gamma Cart System. This procedure does not test the accuracy of the data acquisition software

  10. 241-AZ-101 Mixer Pump Demonstration Test Gamma Cart Acceptance Test Procedure and Quality Test Plan (ATP and QTP)

    International Nuclear Information System (INIS)

    WHITE, D.A.

    2000-01-01

    Shop Test of the Gamma Cart System to be used in the AZ-101 Mixer Pump Demonstration Test. Tests hardware and software. This procedure involves testing the Instrumentation involved with the Gamma Cart System, local and remote, including: depth indicators, speed controls, interface to data acquisition software and the raising and lowering functions. This Procedure will be performed twice, once for each Gamma Cart System. This procedure does not test the accuracy of the data acquisition software

  11. Achievement report for fiscal 1998. Leading research and development of MGC-built superhigh-efficiency turbine system technology; 1998 nendo MGC chokokoritsu turbine system gijutsu sendo kenkyu kaihatsu kenkyu seika

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    To further enhance energy efficiency by improving on the gas turbine system, it is necessary, first of all, to develop superhigh-temperature materials to allow the system to operate at higher temperatures. Described in this report are studies on the application of MGC (melt-growth composite) materials which retain strength and plastic deformation capability even at high temperatures. Various compositions are explored for improvement on fracture toughness and thermal shock resistance. The Al{sub 2}O{sub 3}/YAG system is investigated for the study of relations between microstructural control and fracture toughness. Literature on the development of nanocomposites is surveyed, and a preliminary experiment is discussed for improvement on purity by zone melting crystallization. In a study for an advanced manufacture of larger crystals, technologies of crystal growth condition setting and optimization, quality stabilization, productivity improvement, and crystal size enlargement are taken up. Casting and machining technologies are studied to enable crystals to assume complicated shapes. For the purpose of elucidating the mechanism of the occurrence of properties proper to high temperatures, a study is made on the evaluation of mechanical and physical properties and on the mechanism and control of crystal growth. Also studied are systems (gas turbine cycle, combustor, etc.) to which MGC materials may be applied. (NEDO)

  12. Pengaruh Jarak dan Posisi Nozzle Terhadap Daya Turbin Pelton

    Directory of Open Access Journals (Sweden)

    Yani Kurniawan

    2017-12-01

    Full Text Available Pelton Turbine is a turbine which use nozzle as officers the direction of a stream water in order to move around of blade turbine. The rotating of turbine blade efected by some parameters such as the distance of the nozzle, position of nozzle, diameter of nozzle, number of nozzle, and the geometry shape of the blade turbine. An experimental study to analyze the affect of distance and position nozzle to Pelton Turbine of performance. The research method used experiment parameter was position of nozzle with three variations, first position is the right side horizontal of bottom shaft turbine, second position is vertical to down direction, and third position is the left side horizontal of upper shaft turbine. The parameter of nozzle distance used five variations was 24 cm, 23 cm, 22 cm, 21 cm, dan 20 cm, which measured from the end of position nozzle to blade turbine. The result shows that the right side horizontal of bottom shaft turbine with distance of nozzle 23 cm had the maximum performance to produce a power 125 Watt with the rotation of shaft turbine 263 rpm.

  13. Active load control techniques for wind turbines.

    Energy Technology Data Exchange (ETDEWEB)

    van Dam, C.P. (University of California, Davis, CA); Berg, Dale E.; Johnson, Scott J. (University of California, Davis, CA)

    2008-07-01

    This report provides an overview on the current state of wind turbine control and introduces a number of active techniques that could be potentially used for control of wind turbine blades. The focus is on research regarding active flow control (AFC) as it applies to wind turbine performance and loads. The techniques and concepts described here are often described as 'smart structures' or 'smart rotor control'. This field is rapidly growing and there are numerous concepts currently being investigated around the world; some concepts already are focused on the wind energy industry and others are intended for use in other fields, but have the potential for wind turbine control. An AFC system can be broken into three categories: controls and sensors, actuators and devices, and the flow phenomena. This report focuses on the research involved with the actuators and devices and the generated flow phenomena caused by each device.

  14. Investigation Of Cross-Flow Model Water Turbine

    International Nuclear Information System (INIS)

    Obretenov, V.S.

    1998-01-01

    The research is made with the basic objective of constructing effective stream section of cross-flow turbine. In the research project are presented the results from experimental testing of the cross-flow turbine with various runner. nozzles and draft tubes. The rotational and universal characteristics of the turbine are presented. The experimental results have been analyzed.The results from the research give the possibility to make clear some important aspects of the working process with the cross-flow turbines. The characteristics derived from these tests prove that the stream section of the tested cross-flow turbine can be used as a model in the construction of cross-flow turbines for power electric stations with small capacity

  15. CD19 CAR-T cell therapy for relapsed/refractory acute lymphoblastic leukemia: factors affecting toxicities and long-term efficacies.

    Science.gov (United States)

    Zhang, Li-Na; Song, Yongping; Liu, Delong

    2018-03-15

    The prognosis of adults with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) remains dismal even at this day and age. With salvage chemotherapy, only 29% (range 18 to 44%) of the patients with R/R ALL can be induced into complete remission (CR), with a median overall survival (OS) of 4 months (range 2-6 months). Blinatumomab and inotuzumab ozogamycin (IO) are immunotherapeutic agents that increased CR to 80% and extended survival to 7.7 months in this high-risk population of patients. In the last few years, chimeric antigen receptor (CAR)--engineered T cells have led to major progress in cancer immunotherapy. CD-19 CAR-T cells have been recently approved for high-risk R/R ALL and lymphoma. The data from long-term follow-up of a single-center phase I study of 19-28z CAR-T cell therapy for adult R/R ALL were just published. At the same time, a multicenter phase II study of 19-41BB CAR-T cell therapy for children and young adults with R/R B cell ALL was also published. The two studies provided fresh information with long-term follow-up. This research highlight analyzed the data and proposed future perspectives for further investigation in this rapidly evolving field.

  16. Development of a Childhood Attachment and Relational Trauma Screen (CARTS: a relational-socioecological framework for surveying attachment security and childhood trauma history

    Directory of Open Access Journals (Sweden)

    Paul A. Frewen

    2013-04-01

    Full Text Available Background : Current psychometric measures of childhood trauma history generally fail to assess the relational-socioecological context within which childhood maltreatment occurs, including the relationship of abusers to abused persons, the emotional availability of caregivers, and the respondent's own thoughts, feelings, and actions in response to maltreatment. Objective : To evaluate a computerized approach to measuring the relational-socioecological context within which childhood maltreatment occurs. Method : The psychometric properties of a Childhood Attachment and Relational Trauma Screen (CARTS were evaluated as a retrospective survey of childhood maltreatment history designed to be appropriate for completion by adults. Participants were undergraduates (n=222, an internet sample (n=123, and psychiatric outpatients (n=30. Results : The internal reliability, convergent, and concurrent validity of the CARTS were supported across samples. Paired differences in means and correlations between rated item-descriptiveness to self, mothers, and fathers also accorded with findings of prior attachment and maltreatment research, illustrating the utility of assessing the occurrence and effects of maltreatment within a relational-socioecological framework. Conclusions : Results preliminarily support a new survey methodology for assessing childhood maltreatment within a relational-socioecological framework. Further psychometric evaluation of the CARTS is warranted.

  17. Advanced IGCC/Hydrogen Gas Turbine Development

    Energy Technology Data Exchange (ETDEWEB)

    York, William [General Electric Company, Schenectady, NY (United States); Hughes, Michael [General Electric Company, Schenectady, NY (United States); Berry, Jonathan [General Electric Company, Schenectady, NY (United States); Russell, Tamara [General Electric Company, Schenectady, NY (United States); Lau, Y. C. [General Electric Company, Schenectady, NY (United States); Liu, Shan [General Electric Company, Schenectady, NY (United States); Arnett, Michael [General Electric Company, Schenectady, NY (United States); Peck, Arthur [General Electric Company, Schenectady, NY (United States); Tralshawala, Nilesh [General Electric Company, Schenectady, NY (United States); Weber, Joseph [General Electric Company, Schenectady, NY (United States); Benjamin, Marc [General Electric Company, Schenectady, NY (United States); Iduate, Michelle [General Electric Company, Schenectady, NY (United States); Kittleson, Jacob [General Electric Company, Schenectady, NY (United States); Garcia-Crespo, Andres [General Electric Company, Schenectady, NY (United States); Delvaux, John [General Electric Company, Schenectady, NY (United States); Casanova, Fernando [General Electric Company, Schenectady, NY (United States); Lacy, Ben [General Electric Company, Schenectady, NY (United States); Brzek, Brian [General Electric Company, Schenectady, NY (United States); Wolfe, Chris [General Electric Company, Schenectady, NY (United States); Palafox, Pepe [General Electric Company, Schenectady, NY (United States); Ding, Ben [General Electric Company, Schenectady, NY (United States); Badding, Bruce [General Electric Company, Schenectady, NY (United States); McDuffie, Dwayne [General Electric Company, Schenectady, NY (United States); Zemsky, Christine [General Electric Company, Schenectady, NY (United States)

    2015-07-30

    The objective of this program was to develop the technologies required for a fuel flexible (coal derived hydrogen or syngas) gas turbine for IGCC that met DOE turbine performance goals. The overall DOE Advanced Power System goal was to conduct the research and development (R&D) necessary to produce coal-based IGCC power systems with high efficiency, near-zero emissions, and competitive capital cost. To meet this goal, the DOE Fossil Energy Turbine Program had as an interim objective of 2 to 3 percentage points improvement in combined cycle (CC) efficiency. The final goal is 3 to 5 percentage points improvement in CC efficiency above the state of the art for CC turbines in IGCC applications at the time the program started. The efficiency goals were for NOx emissions of less than 2 ppm NOx (@15 % O2). As a result of the technologies developed under this program, the DOE goals were exceeded with a projected 8 point efficiency improvement. In addition, a new combustion technology was conceived of and developed to overcome the challenges of burning hydrogen and achieving the DOE’s NOx goal. This report also covers the developments under the ARRA-funded portion of the program that include gas turbine technology advancements for improvement in the efficiency, emissions, and cost performance of gas turbines for industrial applications with carbon capture and sequestration. Example applications could be cement plants, chemical plants, refineries, steel and aluminum plants, manufacturing facilities, etc. The DOE’s goal for more than 5 percentage point improvement in efficiency was met with cycle analyses performed for representative IGCC Steel Mill and IGCC Refinery applications. Technologies were developed in this program under the following areas: combustion, larger latter stage buckets, CMC and EBC, advanced materials and coatings, advanced configurations to reduce cooling, sealing and rotor purge flows, turbine aerodynamics, advanced sensors, advancements in first

  18. Development of high temperature turbine

    Energy Technology Data Exchange (ETDEWEB)

    Takahara, Kitao; Nouse, Hiroyuki; Yoshida, Toyoaki; Minoda, Mitsuhiro; Matsusue, Katsutoshi; Yanagi, Ryoji

    1988-07-01

    For the contribution to the development of FJR710, high by-pass ratio turbofan engine, with the study for many years of the development of high efficiency turbine for the jet engine, the first technical prize from the Energy Resource Research Committee was awarded in April, 1988. This report introduced its technical contents. In order to improve the thermal efficiency and enlarge the output, it is very effective to raise the gas temperature at the inlet of gas turbine. For its purpose, by cooling the nozzle and moving blades and having those blades operate at lower temperature than that of the working limitation, they realized, for the first time in Japan, the technique of cooling turbine to heighten the operational gas temperature. By that technique, it was enabled to raise the gas temperature at the inlet of turbine, to 1,350/sup 0/C from 850/sup 0/C. This report explain many important points of study covering the basic test, visualizing flow experiment, material discussion and structural design in the process of development. (9 figs)

  19. Integrated analysis of wind turbines - The impact of power systems on wind turbine design

    DEFF Research Database (Denmark)

    Barahona Garzón, Braulio

    Megawatt-size wind turbines nowadays operate in very complex environmental conditions, and increasingly demanding power system requirements. Pursuing a cost-effective and reliable wind turbine design is a multidisciplinary task. However nowadays, wind turbine design and research areas...... conditions that stem from disturbances in the power system. An integrated simulation environment, wind turbine models, and power system models are developed in order to take an integral perspective that considers the most important aeroelastic, structural, electrical, and control dynamics. Applications...... of the integrated simulation environment are presented. The analysis of an asynchronous machine, and numerical simulations of a fixedspeed wind turbine in the integrated simulation environment, demonstrate the effects on structural loads of including the generator rotor fluxes dynamics in aeroelastic studies. Power...

  20. Thermodynamic analysis of turbine blade cooling on the performance of gas turbine cycle

    International Nuclear Information System (INIS)

    Sarabchi, K.; Shokri, M.

    2002-01-01

    Turbine inlet temperature strongly affects gas turbine performance. Today blade cooling technologies facilitate the use of higher inlet temperatures. Of course blade cooling causes some thermodynamic penalties that destroys to some extent the positive effect of higher inlet temperatures. This research aims to model and evaluate the performance of gas turbine cycle with air cooled turbine. In this study internal and transpiration cooling methods has been investigated and the penalties as the result of gas flow friction, cooling air throttling, mixing of cooling air flow with hot gas flow, and irreversible heat transfer have been considered. In addition, it is attempted to consider any factor influencing actual conditions of system in the analysis. It is concluded that penalties due to blade cooling decrease as permissible temperature of the blade surface increases. Also it is observed that transpiration method leads to better performance of gas turbine comparing to internal cooling method

  1. Parallelization of a three-dimensional whole core transport code DeCART

    Energy Technology Data Exchange (ETDEWEB)

    Jin Young, Cho; Han Gyu, Joo; Ha Yong, Kim; Moon-Hee, Chang [Korea Atomic Energy Research Institute, Yuseong-gu, Daejon (Korea, Republic of)

    2003-07-01

    Parallelization of the DeCART (deterministic core analysis based on ray tracing) code is presented that reduces the computational burden of the tremendous computing time and memory required in three-dimensional whole core transport calculations. The parallelization employs the concept of MPI grouping and the MPI/OpenMP mixed scheme as well. Since most of the computing time and memory are used in MOC (method of characteristics) and the multi-group CMFD (coarse mesh finite difference) calculation in DeCART, variables and subroutines related to these two modules are the primary targets for parallelization. Specifically, the ray tracing module was parallelized using a planar domain decomposition scheme and an angular domain decomposition scheme. The parallel performance of the DeCART code is evaluated by solving a rodded variation of the C5G7MOX three dimensional benchmark problem and a simplified three-dimensional SMART PWR core problem. In C5G7MOX problem with 24 CPUs, a speedup of maximum 21 is obtained on an IBM Regatta machine and 22 on a LINUX Cluster in the MOC kernel, which indicates good parallel performance of the DeCART code. In the simplified SMART problem, the memory requirement of about 11 GBytes in the single processor cases reduces to 940 Mbytes with 24 processors, which means that the DeCART code can now solve large core problems with affordable LINUX clusters. (authors)

  2. The development of CAR design for tumor CAR-T cell therapy.

    Science.gov (United States)

    Xu, Dandan; Jin, Guoliang; Chai, Dafei; Zhou, Xiaowan; Gu, Weiyu; Chong, Yanyun; Song, Jingyuan; Zheng, Junnian

    2018-03-02

    In recent years, the chimeric antigen receptor modified T cells (Chimeric antigen receptor T cells, CAR-T) immunotherapy has developed rapidly, which has been considered the most promising therapy. Efforts to enhance the efficacy of CAR-based anti-tumor therapy have been made, such as the improvement of structures of CAR-T cells, including the development of extracellular antigen recognition receptors, intracellular co-stimulatory molecules and the combination application of CARs and synthetic small molecules. In addition, effects on the function of the CAR-T cells that the space distance between the antigen binding domains and tumor targets and the length of the spacer domains have are also being investigated. Given the fast-moving nature of this field, it is necessary to make a summary of the development of CAR-T cells. In this review, we mainly focus on the present design strategies of CAR-T cells with the hope that they can provide insights to increase the anti-tumor efficacy and safety.

  3. CD47-CAR-T Cells Effectively Kill Target Cancer Cells and Block Pancreatic Tumor Growth.

    Science.gov (United States)

    Golubovskaya, Vita; Berahovich, Robert; Zhou, Hua; Xu, Shirley; Harto, Hizkia; Li, Le; Chao, Cheng-Chi; Mao, Mike Ming; Wu, Lijun

    2017-10-21

    CD47 is a glycoprotein of the immunoglobulin superfamily that is often overexpressed in different types of hematological and solid cancer tumors and plays important role in blocking phagocytosis, increased tumor survival, metastasis and angiogenesis. In the present report, we designed CAR (chimeric antigen receptor)-T cells that bind CD47 antigen. We used ScFv (single chain variable fragment) from mouse CD47 antibody to generate CD47-CAR-T cells for targeting different cancer cell lines. CD47-CAR-T cells effectively killed ovarian, pancreatic and other cancer cells and produced high level of cytokines that correlated with expression of CD47 antigen. In addition, CD47-CAR-T cells significantly blocked BxPC3 pancreatic xenograft tumor growth after intratumoral injection into NSG mice. Moreover, we humanized mouse CD47 ScFv and showed that it effectively bound CD47 antigen. The humanized CD47-CAR-T cells also specifically killed ovarian, pancreatic, and cervical cancer cell lines and produced IL-2 that correlated with expression of CD47. Thus, CD47-CAR-T cells can be used as a novel cellular therapeutic agent for treating different types of cancer.

  4. Otolaryngology Consult Carts: Maximizing Patient Care, Surgeon Efficiency, and Cost Containment.

    Science.gov (United States)

    Royer, Mark C; Royer, Allison K

    2015-11-01

    The objective of this study was to develop an otolaryngology consult cart system to ensure prompt delivery to the bedside of all the unique equipment and medications required for emergent and urgent otolaryngology consults. An otolaryngology practice responsible for emergency room and hospital consult coverage sought to create a cart containing all equipment, medications, and supplies for otolaryngology consults. Meetings with hospital administration and emergency room, nursing, pharmacy, central processing, and operating room staff were held to develop a system for the emergent delivery of the cart to the needed location, sterilization and restocking of equipment between uses, and appropriate billing of supplies. Two months were required from conception to implementation. All equipment was purchased new, including flexible scopes and headlights. The cart is sterilized, restocked, and maintained by central processing after each use. The equipment is available to handle all airway emergencies as well as all common otolaryngology consults and is delivered bedside in less than 5 minutes. The development of a self-contained otolaryngology consult cart requires coordination with a wide variety of hospital departments. This system, while requiring initial monetary and time investment, has resulted in improved patient care, cost containment, and surgeon convenience. © The Author(s) 2015.

  5. Wind turbine operated sailboat

    Energy Technology Data Exchange (ETDEWEB)

    Hall, R.

    1990-07-31

    A wind powered boat is disclosed which incorporates a vertical axis rotary turbine. A shaft portion extends downwardly from the turbine to a water pump, with the boat being provided with a forwardly opening inlet and a rearwardly opening outlet from the water pump. When rotating, the turbine operates the pump by the shaft to draw in water through the inlet, thereby creating a low pressure area in front of the boat, and to force the water out through the outlet for propelling the boat. In a preferred embodiment, the boat has a catamaran construction or is a large ocean going vessel with enough width to provide a buffer to either side of the turbine, and the turbine is the Darrieus rotor type. The pump is a standard centrifugal type of pump. A self adjusting braking device for the turbine is also disclosed, which prevents over-rotation and is also capable of storing heat energy generated during braking. 4 figs.

  6. The swirl turbine

    International Nuclear Information System (INIS)

    Haluza, M; Pochylý, F; Rudolf, P

    2012-01-01

    In the article is introduced the new type of the turbine - swirl turbine. This turbine is based on opposite principle than Kaplan turbine. Euler equation is satisfied in the form gHη h = −u 2 v u2 . From this equation is seen, that inflow of liquid into the runner is without rotation and on the outflow is a rotation of liquid opposite of rotation of runner. This turbine is suitable for small head and large discharge. Some constructional variants of this turbine are introduced in the article and theoretical aspects regarding losses in the draft tube. The theory is followed by computational simulations in Fluent and experiments using laser Doppler anemometry.

  7. Wind Turbines Wake Aerodynamics

    DEFF Research Database (Denmark)

    Vermeer, L.; Sørensen, Jens Nørkær; Crespo, A.

    2003-01-01

    The aerodynamics of horizontal axis wind turbine wakes is studied. The contents is directed towards the physics of power extraction by wind turbines and reviews both the near and the far wake region. For the near wake, the survey is restricted to uniform, steady and parallel flow conditions......, thereby excluding wind shear, wind speed and rotor setting changes and yawed conditions. The emphasis is put on measurements in controlled conditions.For the far wake, the survey focusses on both single turbines and wind farm effects, and the experimental and numerical work are reviewed; the main interest...... is to study how the far wake decays downstream, in order to estimate the effect produced in downstream turbines.The article is further restricted to horizontal axis wind turbines and excludes all other types of turbines....

  8. Superconducting Wind Turbine Generators

    Directory of Open Access Journals (Sweden)

    Yunying Pan

    2016-08-01

    Full Text Available Wind energy is well known as a renewable energy because its clean and less polluted characteristic, which is the foundation of development modern wind electricity. To find more efficient wind turbine is the focus of scientists around the world. Compared from conventional wind turbines, superconducting wind turbine generators have advantages at zero resistance, smaller size and lighter weight. Superconducting wind turbine will inevitably become the main trends in this area. This paper intends to introduce the basic concept and principle of superconductivity, and compare form traditional wind turbine to obtain superiority, then to summary three proposed machine concept.While superconductivity have difficulty  in modern technology and we also have proposed some challenges in achieving superconducting wind turbine finally.

  9. Flow in Pelton turbines

    OpenAIRE

    Furnes, Kjartan

    2013-01-01

    The flow in Pelton turbines is subsonic, turbulent, multiphase (water, air, and water vapor from cavitation), has high speeds, sharp gradients, free surface and dynamic boundary conditions. A static grid is unsuitable for modeling this mainly due to the turbine wheel and the liquid having a non-stationary relative motion.In recent times, significant progress in CFD simulation has been made, which also is relevant for Pelton turbines.Nevertheless, it is still common to perform costly model tes...

  10. Numerical Research on Effects of Turbine Outlet Flow Angle on Aerodynamic Performance of Wind-Ejector of Low-Speed Wind Turbine%涡轮出口气流角对低速风力引射器流场影响的数值研究

    Institute of Scientific and Technical Information of China (English)

    韩万龙; 颜培刚; 韩万金; 何玉荣

    2015-01-01

    为了开发先进的具有广泛适用性的低速风力涡轮,采用涡扇发动机喷管引射技术设计了双涵道风力涡轮,以新型低速引射式风力涡轮的引射混合器为研究对象,采用CFX商用软件基于RANS方程和k-Epsilon湍流模型,数值研究了涡轮出口气流角对风力引射器混合性能的影响。研究结果显示,涡轮出口气流与轴向夹角由0°增至30°,引起了波瓣后侧流向涡量迁移,最大正交涡量降低了1/3,波瓣内侧中部分离对涡与槽道吸力侧分离区汇合,风力引射器内流道总压损失从2.4%增大至5%,此夹角大于10°时外流场对称结构消失并失稳。%The turbofan engine nozzle ejector technology was adopted to design a high-efficiency low speed wind turbine with the double bypass for a broader areas in the world. The aerodynamic characteristics of the wind-ejector of the new wind turbine were numerically researched on turbine outlet flow angle changing based on Reyn⁃olds-averaged NS equations and k-Epsilon turbulence model, using commercial software CFX. Results show that,as the angle between turbine outlet flow and the rotation axis increased from 0°to 30°,the positive vorticity of the stream-wise vortice pairs migrated to the negative vorticity,the maximum normal vorticity was gradually reduced by 1/3,the separation vortex pairs adhesion of the lobes were gradually forced to mix with the separation vortices near the suction surface of the channels, the total pressure loss in the lobes of the wind-ejector in⁃creased from 2.4%to 5%, and if the angle was greater than 10° , the flow stability of the wind turbine outflow field rapidly disappeared.

  11. Wind Turbine Technologies

    DEFF Research Database (Denmark)

    Hansen, Anca Daniela

    2017-01-01

    , and with or without gearboxes, using the latest in power electronics, aerodynamics, and mechanical drive train designs [4]. The main differences between all wind turbine concepts developed over the years, concern their electrical design and control. Today, the wind turbines on the market mix and match a variety......, the design of wind turbines has changed from being convention driven to being optimized driven within the operating regime and market environment. Wind turbine designs have progressed from fixed speed, passive controlled and with drive trains with gearboxes, to become variable speed, active controlled......,6] and to implement modern control system strategies....

  12. Experimental characterization of individual pitch controlled vertical axis wind turbine

    NARCIS (Netherlands)

    Leblanc, B.P.; Simao Ferreira, C.

    2017-01-01

    Research into the Vertical Axis Wind Turbine (VAWT) has been progressing over the last few years due to
    the large shift in design constraints for large floating offshore wind turbines by leveraging tools and experience
    from research beginning in the 1970s and lasting until the HAWT

  13. Optimisation of non-axisymmetric end wall contours for the rotor of a low speed, 1 1/2 stage research turbine with unshrouded blades

    CSIR Research Space (South Africa)

    Bergh, J

    2012-06-01

    Full Text Available 2-dimensional, linear cascades, and therefore do not include a number of features which are present in the flow field of a real turbine. Recent work by Snedden et al involved the introduction of “generic”, non-axisymmetric end wall contours...

  14. A new bladeless hydraulic turbine

    Czech Academy of Sciences Publication Activity Database

    Beran, V.; Sedláček, M.; Maršík, František

    2013-01-01

    Roč. 104, APR 2013 (2013), s. 978-983 ISSN 0306-2619 R&D Projects: GA ČR GAP201/10/0357 Institutional research plan: CEZ:AV0Z20760514 Institutional support: RVO:61388998 Keywords : rolling turbine * low head hydro power * stability of flow Subject RIV: BK - Fluid Dynamics Impact factor: 5.261, year: 2013 http://dx.doi.org/10.1016/j.apenergy.2012.12.016

  15. Golf cart prototype development and navigation simulation using ROS and Gazebo

    Directory of Open Access Journals (Sweden)

    Shimchik Ilya

    2016-01-01

    Full Text Available This paper presents our approach to development of an autonomous golf cart, which will navigate in inaccessible by regular vehicles private areas. For this purpose, we have built a virtual golf course terrain and golf cart model in Gazebo, selected and modernized ROS-based packages in order to use them with Ackermann steering vehicle simulation. To verify our simulation and algorithms, we navigated the golf cart model from one golf hole to another within a virtual 3D golf course. For the real world algorithms’ verification, we developed a small-size vehicle prototype based on Traxxas radio-controlled car model, which is equipped with an on-board controller and sensors. The autonomous navigation of Traxxas-based vehicle prototype has been tested in indoor environment, where it utilized sensory data about environment and vehicle states, and performed localization, optimal trajectory computation and dynamic obstacles’ recognition with adjusting the route in real time.

  16. Chimeric-antigen receptor T (CAR-T) cell therapy for solid tumors: challenges and opportunities.

    Science.gov (United States)

    Xia, An-Liang; Wang, Xiao-Chen; Lu, Yi-Jun; Lu, Xiao-Jie; Sun, Beicheng

    2017-10-27

    Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have been shown to have unprecedented efficacy in B cell malignancies, most notably in B cell acute lymphoblastic leukemia (B-ALL) with up to a 90% complete remission rate using anti-CD19 CAR-T cells. However, CAR T-cell therapy for solid tumors currently is faced with numerous challenges such as physical barriers, the immunosuppressive tumor microenvironment and the specificity and safety. The clinical results in solid tumors have been much less encouraging, with multiple cases of toxicity and a lack of therapeutic response. In this review, we will discuss the current stats and challenges of CAR-T cell therapy for solid tumors, and propose possibl e solutions and future perspectives.

  17. The Coach-Athlete Relationship Questionnaire (CART-Q): development and initial validation.

    Science.gov (United States)

    Jowett, Sophia; Ntoumanis, Nikos

    2004-08-01

    The purpose of the present study was to develop and validate a self-report instrument that measures the nature of the coach-athlete relationship. Jowett et al.'s (Jowett & Meek, 2000; Jowett, in press) qualitative case studies and relevant literature were used to generate items for an instrument that measures affective, cognitive, and behavioral aspects of the coach-athlete relationship. Two studies were carried out in an attempt to assess content, predictive, and construct validity, as well as internal consistency, of the Coach-Athlete Relationship Questionnaire (CART-Q), using two independent British samples. Principal component analysis and confirmatory factor analysis were used to reduce the number of items, identify principal components, and confirm the latent structure of the CART-Q. Results supported the multidimensional nature of the coach-athlete relationship. The latent structure of the CART-Q was underlined by the latent variables of coaches' and athletes' Closeness (emotions), Commitment (cognitions), and Complementarity (behaviors).

  18. Depletion methodology in the 3-D whole core transport code DeCART

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kang Seog; Cho, Jin Young; Zee, Sung Quun

    2005-02-01

    Three dimensional whole-core transport code DeCART has been developed to include a characteristics of the numerical reactor to replace partly the experiment. This code adopts the deterministic method in simulating the neutron behavior with the least assumption and approximation. This neutronic code is also coupled with the thermal hydraulic code CFD and the thermo mechanical code to simulate the combined effects. Depletion module has been implemented in DeCART code to predict the depleted composition in the fuel. The exponential matrix method of ORIGEN-2 has been used for the depletion calculation. The library of including decay constants, yield matrix and others has been used and greatly simplified for the calculation efficiency. This report summarizes the theoretical backgrounds and includes the verification of the depletion module in DeCART by performing the benchmark calculations.

  19. Development of Pelton turbine using numerical simulation

    Energy Technology Data Exchange (ETDEWEB)

    Patel, K; Patel, B; Yadav, M [Hydraulic Engineer, ALSTOM Hydro R and D India Ltd., GIDC Maneja, Vadodara - 390 013, Gujarat (India); Foggia, T, E-mail: patel@power.alstom.co [Hydraulic Engineer, Alstom Hydro France, Etablissement de Grenoble, 82, avenue Leon Blum BP 75, 38041 Grenoble Cedex (France)

    2010-08-15

    This paper describes recent research and development activities in the field of Pelton turbine design. Flow inside Pelton turbine is most complex due to multiphase (mixture of air and water) and free surface in nature. Numerical calculation is useful to understand flow physics as well as effect of geometry on flow. The optimized design is obtained using in-house special optimization loop. Either single phase or two phase unsteady numerical calculation could be performed. Numerical results are used to visualize the flow pattern in the water passage and to predict performance of Pelton turbine at full load as well as at part load. Model tests are conducted to determine performance of turbine and it shows good agreement with numerically predicted performance.

  20. Development of Pelton turbine using numerical simulation

    Science.gov (United States)

    Patel, K.; Patel, B.; Yadav, M.; Foggia, T.

    2010-08-01

    This paper describes recent research and development activities in the field of Pelton turbine design. Flow inside Pelton turbine is most complex due to multiphase (mixture of air and water) and free surface in nature. Numerical calculation is useful to understand flow physics as well as effect of geometry on flow. The optimized design is obtained using in-house special optimization loop. Either single phase or two phase unsteady numerical calculation could be performed. Numerical results are used to visualize the flow pattern in the water passage and to predict performance of Pelton turbine at full load as well as at part load. Model tests are conducted to determine performance of turbine and it shows good agreement with numerically predicted performance.

  1. Development of Pelton turbine using numerical simulation

    International Nuclear Information System (INIS)

    Patel, K; Patel, B; Yadav, M; Foggia, T

    2010-01-01

    This paper describes recent research and development activities in the field of Pelton turbine design. Flow inside Pelton turbine is most complex due to multiphase (mixture of air and water) and free surface in nature. Numerical calculation is useful to understand flow physics as well as effect of geometry on flow. The optimized design is obtained using in-house special optimization loop. Either single phase or two phase unsteady numerical calculation could be performed. Numerical results are used to visualize the flow pattern in the water passage and to predict performance of Pelton turbine at full load as well as at part load. Model tests are conducted to determine performance of turbine and it shows good agreement with numerically predicted performance.

  2. Wind turbines fundamentals, technologies, application, economics

    CERN Document Server

    Hau, Erich

    2013-01-01

    "Wind Turbines" addresses all those professionally involved in research, development, manufacture and operation of wind turbines. It provides a cross-disciplinary overview of modern wind turbine technology and an orientation in the associated technical, economic and environmental fields.  In its revised third edition, special emphasis has been given to the latest trends in wind turbine technology and design, such as gearless drive train concepts, as well as on new fields of application, in particular the offshore utilisation of wind energy. The author has gained experience over decades designing wind energy converters with a major industrial manufacturer and, more recently, in technical consulting and in the planning of large wind park installations, with special attention to economics.

  3. RELIABILITY OF MACHINE ELEMENTS IN WIND TURBINES

    Directory of Open Access Journals (Sweden)

    Willi GRUENDER

    2010-06-01

    Full Text Available Worldwide electrical energy production generated by wind turbines grows at a rate of 30 percent. This doubles the total production every three years. At the same time the power of individual stations goes up by 20 percent annually. Whereas today the towers, rotors and drive trains have to handle 5 MW, in about six to eight years they might produce up to fifteen MW. As a consequence, enormous pressure is put on the wind turbine manufacturers, the component suppliers and the operators. And because prototype and field testing is limited by its expense, the design of new turbines demands thorough analysis and simulation. Looking at the critical components of a wind turbine this paper describes advanced design tools which help to anticipate failures, but also assists in optimizing reliability and service life. Development of the software tools has been supported by research activities in many universities.

  4. Study of wind turbine foundations in cold climates

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-11-01

    This report provides an overview of the processes at work in soil in cold climates and their effect on wind turbine foundations. Havsnaes wind farm consists of 48 turbines located in Jaemtland county in central Sweden. Havsnaes has provided an appropriate research environment to investigate the engineering challenges related to the design and construction of wind turbine foundations in sub-arctic conditions and the experienced gained from this project informs this report.

  5. CAR-T cells: the long and winding road to solid tumors.

    Science.gov (United States)

    D'Aloia, Maria Michela; Zizzari, Ilaria Grazia; Sacchetti, Benedetto; Pierelli, Luca; Alimandi, Maurizio

    2018-02-15

    Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the "next generation" of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the inability to reach and survive in the microenvironment surrounding the neoplastic foci. The intricate net of cross-interactions occurring between tumor components, stromal and immune cells leads to an ineffective anergic status favoring the evasion from the host's defenses. Our goal is hereby to trace the road imposed by solid tumors to CAR-T cells, highlighting pitfalls and strategies to be developed and refined to possibly overcome these hurdles.

  6. Incorporation of Immune Checkpoint Blockade into Chimeric Antigen Receptor T Cells (CAR-Ts): Combination or Built-In CAR-T.

    Science.gov (United States)

    Yoon, Dok Hyun; Osborn, Mark J; Tolar, Jakub; Kim, Chong Jai

    2018-01-24

    Chimeric antigen receptor (CAR) T cell therapy represents the first U.S. Food and Drug Administration approved gene therapy and these engineered cells function with unprecedented efficacy in the treatment of refractory CD19 positive hematologic malignancies. CAR translation to solid tumors is also being actively investigated; however, efficacy to date has been variable due to tumor-evolved mechanisms that inhibit local immune cell activity. To bolster the potency of CAR-T cells, modulation of the immunosuppressive tumor microenvironment with immune-checkpoint blockade is a promising strategy. The impact of this approach on hematological malignancies is in its infancy, and in this review we discuss CAR-T cells and their synergy with immune-checkpoint blockade.

  7. Incorporation of Immune Checkpoint Blockade into Chimeric Antigen Receptor T Cells (CAR-Ts: Combination or Built-In CAR-T

    Directory of Open Access Journals (Sweden)

    Dok Hyun Yoon

    2018-01-01

    Full Text Available Chimeric antigen receptor (CAR T cell therapy represents the first U.S. Food and Drug Administration approved gene therapy and these engineered cells function with unprecedented efficacy in the treatment of refractory CD19 positive hematologic malignancies. CAR translation to solid tumors is also being actively investigated; however, efficacy to date has been variable due to tumor-evolved mechanisms that inhibit local immune cell activity. To bolster the potency of CAR-T cells, modulation of the immunosuppressive tumor microenvironment with immune-checkpoint blockade is a promising strategy. The impact of this approach on hematological malignancies is in its infancy, and in this review we discuss CAR-T cells and their synergy with immune-checkpoint blockade.

  8. A Take Stock of Turbine Blades Failure Phenomenon

    Science.gov (United States)

    Roy, Abhijit

    2018-02-01

    Turbine Blade design and engineering is one of the most complicated and important aspects of turbine technology. Experiments with blades can be simple or very complicated, depending upon parameters of analysis. Turbine blades are subjected to vigorous environments, such as high temperatures, high stresses, and a potentially high vibration environment. All these factors can lead to blade failures, which can destroy the turbine, and engine, so careful design is the prime consideration to resist those conditions. A high cycle of fatigue of compressor and turbine blades due to high dynamic stress caused by blade vibration and resonance within the operating range of machinery is common failure mode for turbine machine. Continuous study and investigation on failure of turbine blades are going on since last five decades. Some review papers published during these days aiming to present a review on recent studies and investigations done on failures of turbine blades. All the detailed literature related with the turbine blades has not been described but emphasized to provide all the methodologies of failures adopted by various researches to investigate turbine blade. This paper illustrate on various factors of failure.

  9. Proposed applications with implementation techniques of the upcoming renewable energy resource, The Tesla Turbine

    International Nuclear Information System (INIS)

    Khan, M Usman Saeed; Maqsood, M Irfan; Ali, Ehsan; Jamal, Shah; Javed, M

    2013-01-01

    Recent research has shown that tesla turbine can be one of the future efficient sources of renewable energy. Modern techniques used for designing of tesla turbine have given optimum results regarding efficiency and applications. In this paper we have suggested fully coordinated applications of tesla turbine in different fields particularly in power generation at both low level and high level generation. In Energy deficient countries the tesla turbine has wide range of applications and it can play an important role in energy management system. Our proposed applications includes, - the use of tesla turbine as renewable energy resource; - using tesla turbine in distributed generation system; - use of tesla turbine at home for power generation; - use of tesla turbine in irrigation channels; - using tesla turbine in hybrid electric vehicles; All applications are explained with the help of flow charts and block diagrams and their implementation techniques are also explained in details. The results of physical experiments and simulations are also included for some applications.

  10. Guide to hydro turbines

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    This listing is a guide to turbines for hydroelectric projects of independent energy projects. The listing is in directory format and includes the supplier's name, the name of the supplier's contact, address, telephone and FAX numbers and a description of the company and the types of turbines, services and expertise available for energy projects. The listing is international in scope

  11. Improvement of turbine materials

    International Nuclear Information System (INIS)

    Jakobeit, W.; Pfeifer, J.P.

    1982-01-01

    Materials for turbine blades and rotors are discussed with a view to the following subjects: Long period creep behaviour, gas/metal reactions, fatigue behaviour in long-term and creep strength testing, fracture mechanics testing, creep/fatigue interactions, development of a turbine blade of TZM, jointing of TZM, decontamination. (orig./IHOE) [de

  12. Changes in RANKL during the first two years after cART initiation in HIV-infected cART naïve adults

    DEFF Research Database (Denmark)

    Mathiesen, Inger Hee Mabuza; Salem, Mohammad; Gerstoft, Jan

    2017-01-01

    accelerated bone loss could be mediated by increased soluble RANKL (sRANKL) levels associated with CD4+ T cell recovery. METHODS: We used multiplex immunoassays to determine sRANKL and OPG concentrations in plasma from 48 HIV patients at baseline and 12, 24, 48 and 96 weeks after cART initiation. RESULTS......: Soluble RANKL changed significantly over time (overall p = 0.02) with 25% decrease (95% CI: -42 to -5) at week 24 compared to baseline and stabilized at a lower level thereafter. We found no correlation between CD4+ T cell count increment and changes in sRANKL or between percentage change in BMD...... and changes in sRANKL. CONCLUSION: In this study there was no indication that the accelerated bone loss after cART initiation was mediated by early changes in sRANKL due to CD4+ T cell recovery. Future studies should focus on the initial weeks after initiation of cART. TRIAL REGISTRATION: Clinical...

  13. Achievement report for fiscal 1992. Research and development of ceramic gas turbine (Study on its adaptability with society); 1992 nendo ceramic gas turbine no kenkyu kaihatsu seika hokokusho. Shakai tekigosei kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-05-01

    With an objective to attain a guideline for putting ceramic gas turbine (CGT) into practical application, conceptual discussions on the CGT based industrial cogeneration system (CGS) and the CGT based CGS simulations were performed to discuss quantitatively the effects of the system introduction, and estimate latent markets based on the result of calculating the introduction effects. In addition, investigations were carried out on Germany as the advanced nation with regard to the systems according to utilization patterns, load profiles, operation cost, exhaust gas measures, and the related laws and regulations. The activities may be summarized specifically as follows: 1) putting the back-data for industrial energy demand into order; 2) calculation of CGT introduction effects in industrial areas; 3) discussions on latent demand and social adaptability of CGT in the industrial area; and 4) investigations in overseas countries. Item 2 is composed of the conceptual design of industrial CGT/CGS, and the simulations on the actual status of energy demand in industrial business operation centers and on the effects of the industrial CGT/CGS. (NEDO)

  14. FY 1993 Research and development of ceramic gas turbines. Development of methods of testing and evaluating ceramic member bonding techniques; 1993 nendo ceramic gas turbine no kenkyu kaihatsu seika hokokusho. Ceramic buzai setsugo gijutsu no shiken hyoka hoho no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-05-01

    Studies are conducted to establish the methods of testing and evaluating applicability of ceramic-metal bonding for ceramic gas turbines, and the FY 1993 results are reported. The program involves measurement of residual stress by the X-ray method and durability tests for the joints of silicon nitride and austenitic stainless steel with copper as the intermediate layer, and analysis and classification of the strength/durability test results obtained until the previous fiscal year by the finite element method, to evaluate applicability of the joining. For the strength characteristics at high temperature, the test pieces tend to lose strength at 400 degrees C and higher, and high-temperature strength as cross-head displacement speed increases. The upper limit of bending strength at room temperature decreases as number of thermal cycles increases. The test pieces subjected to thermal cycles have a higher bending strength at high temperature than at room temperature. The results of the two-dimensional plasticity analysis of the residual stress in the joint by the finite element method are in good agreement with the results by the X-ray method. (NEDO)

  15. FY 1992 Research and development of ceramic gas turbines. Reliability demonstration tests for ceramic members; 1992 nendo ceramic gas turbine no kenkyu kaihatsu seika hokokusho. Ceramic buzai no shinraisei kakusho shiken

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-05-01

    The creep rupture demonstration testing methods and non-destructive testing technologies are investigated for ceramic members, to promote development of ceramic gas turbines (CGT's), and the FY 1992 results are reported. For creep rupture demonstration testing methods, 3 types of silicon nitride as the CGT rotor materials are tested for tensile creep rupture at a rated temperature level (1200 degrees C) in the operating atmosphere (in the air), and applicability of the Larson-Miller method to ceramic members is investigated. It is found that Larson-Miller index, determined for each test temperature, is useful for explaining the test results, and analysis of the data by the Larson-Miller method is applicable to prediction of creep rupture life for specific members. For the non-destructive testing technologies to be applied to CGT members, the studied items include determination of white X-ray absorption coefficient by the film method and optimization of X-ray photographing, and the good results are produced. (NEDO)

  16. Achievement report for fiscal 1998. Research and development of ceramic gas turbine (Reliability verification test for ceramic members); 1998 nendo ceramic gas turbine no kenkyu kaihatsu seika hokokusho. Ceramic buzai no shinraisei kakusho shiken

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-05-01

    For a ceramic gas turbine to achieve efficiency of 42%, materials capable of withstanding approximately 1300 degrees C are required. In fiscal 1998, the mechanism of creep deformation and life prediction are studied, with specimens exposed to a short-term high-stress conditions equivalent to a time to fracture of 1000h. It is known after studies in the past that, under a stress of approximately 240Mpa, the logarithmic values of the load stress and time to fracture may be described by two differently inclined straight lines. Strain is accurately measured by use of a CCD camera for the determination of a creep curve, and then stress indexes are worked out. It is then found that the stress indexes are 4 on the lower stress side of 260MPa and 11 on the higher stress side of the same. This enables the extrapolation of short-term creep fracture data for the prediction of long-term life. No large-scale reduction in resistance to creep due to changes in the crystal phase is not predicted. Longitudinal sound wave speeds are measured, and the result manifestly describes how the longitudinal sound wave speed slows down with the progress of creepage in the material. Reference is also made to international reports about the study of ceramics performance tests and evaluation methods, international joint studies about mechanical properties tests, and the international round robin test of material powder. (NEDO)

  17. Achievement report for fiscal 1990. Research and development of ceramic gas turbine (Study on its adaptability with society); 1990 nendo ceramic gas turbine no kenkyu kaihatsu seika hokokusho. Shakai tekigosei kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-05-01

    With an objective to assist proliferation of ceramic gas turbine (CGT) which is desired of being put into practical use at an early time because of its effects of energy conservation, environmental preservation, and economic influence, investigations and studies were made on the CGT systems for cogeneration and portable power generation with regard to their latent markets, utilization patterns, and durability. In Section 1, investigations were given on stocking quantity by size in civil use buildings as the back-data for identification of effects by CGT and for estimation of its proliferation; identification of electric power to heat ratio (heat quantity/electric power amount) and patterns in use of energy in industries promising in CGT introduction; and on stocking quantity, energy demand and utilization patterns in industrial facilities. In Section 2, discussions were given on heat-power characteristics of the CGT, and energy utilization systems as the feasibility study on applicability of the cogeneration using the CGT. In Section 3, discussions were given on corrosion resistance of non-oxide based ceramics in relation with durability of the CGT, and oxidation behavior of silicon carbides in high temperature steam. In Section 4, future investigation assignments were discussed. (NEDO)

  18. Achievement report for fiscal 1989. Research and development of ceramic gas turbine (Study on its adaptability with society); 1989 nendo ceramic gas turbine no kenkyu kaihatsu seika hokokusho. Shakai tekigosei kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-05-01

    Ceramic gas turbine (CGT) is superior in the aspects of high efficiency, low pollution, multi-kind fuel performance, small size, and light weight. Its utilization field is broad, whereas putting it into practical use at an early time is desired from the viewpoints of energy conservation, reduction in CO2 emission, resource conservation, and economic influence. The utilization field of CGT may include cogeneration and portable power generator, but putting it into practical use requires that it be superior in environment protection performance such as gas exhaust, noise and vibration, economic performance, safety, and adaptability with the utilization fields. From such a viewpoint, discussions were given on its adaptability with the society based on different characteristics of the CGT, and other conditions such as related laws and regulations. The first edition investigated the developmental trends in ceramic materials, and the second edition studied the CGT utilizing systems, in particular, the status of utilization and proliferation of the current cogeneration systems. The edition evaluated various conditions required for conceptual design of the system. The third edition put into order the environmental regulations and future trends in order to identify the effect of introducing the CGT. (NEDO)

  19. Power Curve of the AWEC-60 wind turbine

    International Nuclear Information System (INIS)

    Avia, F.

    1992-01-01

    The experimental wind turbine AWEC-60 was developed to evaluate the possibilities of the Large Wind turbines, from the technical and economical point of view. The project was developed by a spanish-german group, integrated by Union Fenosa, Asinel, M.A.N. Neue Technologie and the Instituto de Energias Renovables from CIEMAT, starting the operation during the year 1990. In this paper, the obtention of the wind turbine power curve is presented, which has been obtained in agreement with the Recommended Practices for Wind Turbine Testing and Evaluation from the Executive Committee for the Research and Development on Wind Energy, of the International Energy Agency (AIE). Using the functioning data of the wind turbine correspondig to the first quarter of the year 1991, the power curves have been obtained, and the results have been compared with the curves measured in other similar Large wind turbines. (Author) 7 refs

  20. Research of Wake Optimization Model of Single-row Wind Turbines and Its Application%单列风电机组尾流优化模型的研究及应用

    Institute of Scientific and Technical Information of China (English)

    张宇

    2017-01-01

    In order to achieve the best economical efficiency in a wind power plant,taking actual project cases as the starting point,an improved Park wake model was chosen to establish the arrangement schemes for different wind turbines on the direction of prevailing wind.The objective functions of optimization wake models based on four spacings of wind turbine,three atmospheric stabilities and two types of wind turbines were compared.The results show that with the increasing spacing ratio (L1/L2) of wind turbine,the total wake of wind turbine firstly decreases and then increases,and it reaches a minimum as L1/L2 equals to 1.Given the wake effect,the annual power generation rises at first and then drops down.And it will reach its peak value when L1/L2 equals to 1.This conclusion will provide a new theoretical basis for the further research on the wake optimization model.%为了使风电场的经济性达到最佳,以实际工程案例为出发点,选择改进的Park尾流模型,在盛行风向上建立不同风电机组的布置方案,对比分析了采用四种风电机组间距、三种大气稳定度和两种风电机组型号的尾流优化模型目标函数.结果表明,随着风电机组间距比L1/L2的增加,风电机组的总尾流先减小后增加,且在L1/L2等于1时达到最小;考虑尾流效应的年总发电量先增加后减小,且在L1/L2等于1时达到最大.这一结论将为今后尾流优化模型的研究提供新的理论依据.

  1. Description and evaluation of foreign wind turbine technology

    International Nuclear Information System (INIS)

    1995-06-01

    It is stated that sales of Danish-manufactured wind turbines abroad are decreasing due to an increase in production, marketing and technology research in other countries. The aim was to give an account of this international development which could form the basis for the future strategies of the Danish Wind turbine industry. The study is based on a survey of relevant literature, interviews with experts on the subject and the collection of the latest data. The survey is limited to wind turbines with a larger capacity than 50 kW. Recommendations are given as to how to conserve and develop the market for Danish wind turbines. (AB) 17 refs

  2. Vibration-Based Damage Identification in Wind Turbine Blades

    DEFF Research Database (Denmark)

    Ulriksen, Martin Dalgaard; Tcherniak, Dmitri; Damkilde, Lars

    Due to the existing trend of placing wind turbines in impassable terrain, for example, offshore, these structures constitute prime candidates for being subjected to structural health monitoring (SHM). The wind turbine blades have in particular been paid research attention [1] as these compose one...... of the most common and critical components to fail in the turbines [2]. The standard structural integrity assessment of blades is based on visual inspection, which requires the turbine in question to be stopped while inspections are conducted. This procedure is extremely costly and tedious, hence emphasizing...

  3. CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients.

    Science.gov (United States)

    Turtle, Cameron J; Hanafi, Laïla-Aïcha; Berger, Carolina; Gooley, Theodore A; Cherian, Sindhu; Hudecek, Michael; Sommermeyer, Daniel; Melville, Katherine; Pender, Barbara; Budiarto, Tanya M; Robinson, Emily; Steevens, Natalia N; Chaney, Colette; Soma, Lorinda; Chen, Xueyan; Yeung, Cecilia; Wood, Brent; Li, Daniel; Cao, Jianhong; Heimfeld, Shelly; Jensen, Michael C; Riddell, Stanley R; Maloney, David G

    2016-06-01

    T cells that have been modified to express a CD19-specific chimeric antigen receptor (CAR) have antitumor activity in B cell malignancies; however, identification of the factors that determine toxicity and efficacy of these T cells has been challenging in prior studies in which phenotypically heterogeneous CAR-T cell products were prepared from unselected T cells. We conducted a clinical trial to evaluate CD19 CAR-T cells that were manufactured from defined CD4+ and CD8+ T cell subsets and administered in a defined CD4+:CD8+ composition to adults with B cell acute lymphoblastic leukemia after lymphodepletion chemotherapy. The defined composition product was remarkably potent, as 27 of 29 patients (93%) achieved BM remission, as determined by flow cytometry. We established that high CAR-T cell doses and tumor burden increase the risks of severe cytokine release syndrome and neurotoxicity. Moreover, we identified serum biomarkers that allow testing of early intervention strategies in patients at the highest risk of toxicity. Risk-stratified CAR-T cell dosing based on BM disease burden decreased toxicity. CD8+ T cell-mediated anti-CAR transgene product immune responses developed after CAR-T cell infusion in some patients, limited CAR-T cell persistence, and increased relapse risk. Addition of fludarabine to the lymphodepletion regimen improved CAR-T cell persistence and disease-free survival. Immunotherapy with a CAR-T cell product of defined composition enabled identification of factors that correlated with CAR-T cell expansion, persistence, and toxicity and facilitated design of lymphodepletion and CAR-T cell dosing strategies that mitigated toxicity and improved disease-free survival. ClinicalTrials.gov NCT01865617. R01-CA136551; Life Science Development Fund; Juno Therapeutics; Bezos Family Foundation.

  4. A Summary of Environmentally Friendly Turbine Design Concepts

    Energy Technology Data Exchange (ETDEWEB)

    Odeh, Mufeed [United States Geological Survey - BRD, Turners Falls, MA (United States)

    1999-07-01

    The Advanced Hydropower Turbine System Program (AHTS) was created in 1994 by the U.S. Department of Energy, Electric Power Research Institute, and the Hydropower Research Foundation. The Program’s main goal is to develop “environmentally friendly” hydropower turbines. The Program’s first accomplishment was the development of conceptual designs of new environmentally friendly turbines. In order to do so, two contractors were competitively selected. The ARL/NREC team of engineers and biologists provided a conceptual design for a new turbine runner*. The new runner has the potential to generate hydroelectricity at close to 90% efficiency. The Voith team produced new fish-friendly design criteria for Kaplan and Francis turbines that can be incorporated in units during rehabilitation projects or in new hydroelectric facilities**. These include the use of advanced plant operation, minimum gap runners, placement of wicket gates behind stay vanes, among others. The Voith team will also provide design criteria on aerating Francis turbines to increase dissolved oxygen content. Detailed reviews of the available literature on fish mortality studies, causation of injuries to fish, and available biological design criteria that would assist in the design of fish-friendly turbines were performed. This review identified a need for more biological studies in order to develop performance criteria to assist turbine manufacturers in designing a more fish-friendly turbine.

  5. Preconception use of cART by HIV-positive pregnant women increases the risk of infants being born small for gestational age

    NARCIS (Netherlands)

    Snijdewind, Ingrid J. M.; Smit, Colette; Godfried, Mieke H.; Bakker, Rachel; Nellen, Jeannine F. J. B.; Jaddoe, Vincent W. V.; van Leeuwen, Elisabeth; Reiss, Peter; Steegers, Eric A. P.; van der Ende, Marchina E.

    2018-01-01

    Background The benefits of combination anti-retroviral therapy (cART) in HIV-positive pregnant women (improved maternal health and prevention of mother to child transmission [pMTCT]) currently outweigh the adverse effects due to cART. As the variety of cART increases, however, the question arises as

  6. Anorexigenní neuropeptid CART v regulaci příjmu potravy

    Czech Academy of Sciences Publication Activity Database

    Nagelová, Veronika; Železná, Blanka; Maletínská, Lenka

    2014-01-01

    Roč. 108, č. 4 (2014), s. 354-357 ISSN 0009-2770 R&D Projects: GA ČR GAP303/10/1368 Institutional support: RVO:61388963 Keywords : CART * cocaine and amphetamine regulated transcript * anorexigenic neuropeptide Subject RIV: CE - Biochemistry Impact factor: 0.272, year: 2014

  7. Robust Takagi-Sugeno Fuzzy Dynamic Regulator for Trajectory Tracking of a Pendulum-Cart System

    Directory of Open Access Journals (Sweden)

    Miguel A. Llama

    2015-01-01

    Full Text Available Starting from a nonlinear model for a pendulum-cart system, on which viscous friction is considered, a Takagi-Sugeno (T-S fuzzy augmented model (TSFAM as well as a TSFAM with uncertainty (TSFAMwU is proposed. Since the design of a T-S fuzzy controller is based on the T-S fuzzy model of the nonlinear system, then, to address the trajectory tracking problem of the pendulum-cart system, three T-S fuzzy controllers are proposed via parallel distributed compensation: (1 a T-S fuzzy servo controller (TSFSC designed from the TSFAM; (2 a robust TSFSC (RTSFSC designed from the TSFAMwU; and (3 a robust T-S fuzzy dynamic regulator (RTSFDR designed from the RTSFSC with the addition of a T-S fuzzy observer, which estimates cart and pendulum velocities. Both TSFAM and TSFAMwU are comprised of two fuzzy rules and designed via local approximation in fuzzy partition spaces technique. Feedback gains for the three fuzzy controllers are obtained via linear matrix inequalities approach. A swing-up controller is developed to swing the pendulum up from its pendant position to its upright position. Real-time experiments validate the effectiveness of the proposed schemes, keeping the pendulum in its upright position while the cart follows a reference signal, standing out the RTSFDR.

  8. Fire behavior of e-tablets stored in aircraft galley carts.

    Science.gov (United States)

    2015-04-01

    The use of electronic-tablets (e-tablets) as replacements for conventional in-flight entertainment systems has gained popularity : among airlines globally. Innovative methods of storing and charging e-tablets in galley carts have been suggested or ar...

  9. New analogs of the CART peptide with anorexigenic potency: The importance of individual disulfide bridges

    Czech Academy of Sciences Publication Activity Database

    Blechová, Miroslava; Nagelová, Veronika; Žáková, Lenka; Demianova, Zuzana; Železná, Blanka; Maletínská, Lenka

    2013-01-01

    Roč. 39, January (2013), s. 138-144 ISSN 0196-9781 R&D Projects: GA ČR GAP303/10/1368 Institutional support: RVO:61388963 Keywords : CART peptide analogs * sulfitolysis * PC12 cells * binding * food intake Subject RIV: CE - Biochemistry Impact factor: 2.614, year: 2013

  10. Automated cart with VIS/NIR hyperspectral reflectance and fluorescence imaging capabilities

    Science.gov (United States)

    A system to take high-resolution VIS/NIR hyperspectral reflectance and fluorescence images in outdoor fields using ambient lighting or a pulsed laser (355 nm), respectively, for illumination was designed, built, and tested. Components of the system include a semi-autonomous cart, a gated-intensified...

  11. Health constraints of Cart Horses in the Dry warm, Sub-moist tepid ...

    African Journals Online (AJOL)

    The objectives of this study were to identify the major health and welfare constraints of cart horses in the dry warm, sub-moist tepid and moist cool climatic zones of Ethiopia. The study was cross sectional and a total of 837 horses were examined. Five major health problems and welfare issues were identified. Lymphangitis ...

  12. CAR-T cells and combination therapies: What's next in the immunotherapy revolution?

    Science.gov (United States)

    Ramello, Maria C; Haura, Eric B; Abate-Daga, Daniel

    2018-03-01

    Cancer immunotherapies are dramatically reshaping the clinical management of oncologic patients. For many of these therapies, the guidelines for administration, monitoring, and management of associated toxicities are still being established. This is especially relevant for adoptively transferred, genetically-modified T cells, which have unique pharmacokinetic properties, due to their ability to replicate and persist long-term, following a single administration. Furthermore, in the case of CAR-T cells, the use of synthetic immune receptors may impact signaling pathways involved in T cell function and survival in unexpected ways. We, herein, comment on the most salient aspects of CAR-T cell design and clinical experience in the treatment of solid tumors. In addition, we discuss different possible scenarios for combinations of CAR-T cells and other treatment modalities, with a special emphasis on kinase inhibitors, elaborating on the strategies to maximize synergism. Finally, we discuss some of the technologies that are available to explore the molecular events governing the success of these therapies. The young fields of synthetic and systems biology are likely to be major players in the advancement of CAR-T cell therapies, providing the tools and the knowledge to engineer patients' T lymphocytes into intelligent cancer-fighting micromachines. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. A Rapid Cell Expansion Process for Production of Engineered Autologous CAR-T Cell Therapies.

    Science.gov (United States)

    Lu, Tangying Lily; Pugach, Omar; Somerville, Robert; Rosenberg, Steven A; Kochenderfer, James N; Better, Marc; Feldman, Steven A

    2016-12-01

    The treatment of B-cell malignancies by adoptive cell transfer (ACT) of anti-CD19 chimeric antigen receptor T cells (CD19 CAR-T) has proven to be a highly successful therapeutic modality in several clinical trials. 1-6 The anti-CD19 CAR-T cell production method used to support initial trials relied on numerous manual, open process steps, human serum, and 10 days of cell culture to achieve a clinical dose. 7 This approach limited the ability to support large multicenter clinical trials, as well as scale up for commercial cell production. Therefore, studies were completed to streamline and optimize the original National Cancer Institute production process by removing human serum from the process in order to minimize the risk of viral contamination, moving process steps from an open system to functionally closed system operations in order to minimize the risk of microbial contamination, and standardizing additional process steps in order to maximize process consistency. This study reports a procedure for generating CD19 CAR-T cells in 6 days, using a functionally closed manufacturing process and defined, serum-free medium. This method is able to produce CD19 CAR-T cells that are phenotypically and functionally indistinguishable from cells produced for clinical trials by the previously described production process.

  14. Control of trunk motion following sudden stop perturbations during cart pushing.

    Science.gov (United States)

    Lee, Yun-Ju; Hoozemans, Marco J M; van Dieën, Jaap H

    2011-01-04

    External perturbations during pushing tasks have been suggested to be a risk factor for low-back symptoms. An experiment was designed to investigate whether self-induced and externally induced sudden stops while pushing a high inertia cart influence trunk motions, and how flexor and extensor muscles counteract these perturbations. Twelve healthy male participants pushed a 200 kg cart at shoulder height and hip height. Pushing while walking was compared to situations in which participants had to stop the cart suddenly (self-induced stop) or in which the wheels of the cart were unexpectedly blocked (externally induced stop). For the perturbed conditions, the peak values and the maximum changes from the reference condition (pushing while walking) of the external moment at L5/S1, trunk inclination and electromyographic amplitudes of trunk muscles were determined. In the self-induced stop, a voluntary trunk extension occurred. Initial responses in both stops consisted of flexor and extensor muscle cocontraction. In self-induced stops this was followed by sustained extensor activity. In the externally induced stops, an external extension moment caused a decrease in trunk inclination. The opposite directions of the internal moment and trunk motion in the externally induced stop while pushing at shoulder height may indicate insufficient active control of trunk posture. Consequently, sudden blocking of the wheels in pushing at shoulder height may put the low back at risk of mechanical injury. Copyright © 2010 Elsevier Ltd. All rights reserved.

  15. Wave-Rotor-Enhanced Gas Turbine Engine Demonstrator

    National Research Council Canada - National Science Library

    Welch, Gerard

    1999-01-01

    The U.S. Army Research Laboratory, NASA Glenn Research Center, and Rolls-Royce Allison are working collaboratively to demonstrate the benefits and viability of a wave-rotor-topped gas turbine engine...

  16. Wind Turbine Lightning Protection Project: 1999-2001

    Energy Technology Data Exchange (ETDEWEB)

    McNiff, B.

    2002-05-01

    A lightning protection research and support program was instituted by NREL to help minimize lightning damage to wind turbines in the United States. This paper provides the results of a field test program, an evaluation of protection on selected turbines, and a literature search as well as the dissemination of the accumulated information.

  17. Detection of Wind Turbine Power Performance Abnormalities Using Eigenvalue Analysis

    DEFF Research Database (Denmark)

    Skrimpas, Georgios Alexandros; Sweeney, Christian Walsted; Marhadi, Kun Saptohartyadi

    2014-01-01

    Condition monitoring of wind turbines is a field of continu- ous research and development as new turbine configurations enter into the market and new failure modes appear. Systems utilising well established techniques from the energy and in- dustry sector, such as vibration analysis...

  18. Aircraft gas turbines

    Energy Technology Data Exchange (ETDEWEB)

    Sekido, T [Ishikawajima-Harima Heavy Industries, Co. Ltd., Tokyo (Japan)

    1994-03-01

    Current developmental activities of aircraft gas turbines in Japan are reviewed. V2500-A5 engine with thrust of 30,000 LBF is scheduled to be used for real aircraft in 1994, and intensive developmental activities are also proceeding in larger engines over 90,000 LBF. Recently, developmental programs of engines for 75-100 seat aircraft have been actively discussed, and Japanese engine makers are having discussions towards international collaboration. Such engines will be high bypass turbofans of 12,000-22,000 LBF. Development of SST/HST engines in a speed range from subsonic to Mach 5 is under the initiative of the Agency of Industrial Science and Technology. The Technical Research and Development Institute of Japan, Defence Agency achieved the target thrust of 3.4 tons in the small turbofan engine program, and the small turboshaft engine for small helicopters is also under development. Both National Aerospace Laboratory (NAL) and Institute of Space and Aeronautical Science (ISAS) are now conducting the research programs on turbo-ramjet engines under a component test phase. 1 fig.

  19. The nucleus accumbens 5-HTR4-CART pathway ties anorexia to hyperactivity

    Science.gov (United States)

    Jean, A; Laurent, L; Bockaert, J; Charnay, Y; Dusticier, N; Nieoullon, A; Barrot, M; Neve, R; Compan, V

    2012-01-01

    In mental diseases, the brain does not systematically adjust motor activity to feeding. Probably, the most outlined example is the association between hyperactivity and anorexia in Anorexia nervosa. The neural underpinnings of this ‘paradox', however, are poorly elucidated. Although anorexia and hyperactivity prevail over self-preservation, both symptoms rarely exist independently, suggesting commonalities in neural pathways, most likely in the reward system. We previously discovered an addictive molecular facet of anorexia, involving production, in the nucleus accumbens (NAc), of the same transcripts stimulated in response to cocaine and amphetamine (CART) upon stimulation of the 5-HT4 receptors (5-HTR4) or MDMA (ecstasy). Here, we tested whether this pathway predisposes not only to anorexia but also to hyperactivity. Following food restriction, mice are expected to overeat. However, selecting hyperactive and addiction-related animal models, we observed that mice lacking 5-HTR1B self-imposed food restriction after deprivation and still displayed anorexia and hyperactivity after ecstasy. Decryption of the mechanisms showed a gain-of-function of 5-HTR4 in the absence of 5-HTR1B, associated with CART surplus in the NAc and not in other brain areas. NAc-5-HTR4 overexpression upregulated NAc-CART, provoked anorexia and hyperactivity. NAc-5-HTR4 knockdown or blockade reduced ecstasy-induced hyperactivity. Finally, NAc-CART knockdown suppressed hyperactivity upon stimulation of the NAc-5-HTR4. Additionally, inactivating NAc-5-HTR4 suppressed ecstasy's preference, strengthening the rewarding facet of anorexia. In conclusion, the NAc-5-HTR4/CART pathway establishes a ‘tight-junction' between anorexia and hyperactivity, suggesting the existence of a primary functional unit susceptible to limit overeating associated with resting following homeostasis rules. PMID:23233022

  20. Simulation at the point of care: reduced-cost, in situ training via a mobile cart.

    Science.gov (United States)

    Weinstock, Peter H; Kappus, Liana J; Garden, Alexander; Burns, Jeffrey P

    2009-03-01

    The rapid growth of simulation in health care has challenged traditional paradigms of hospital-based education and training. Simulation addresses patient safety through deliberative practice of high-risk low-frequency events within a safe, structured environment. Despite its inherent appeal, widespread adoption of simulation is prohibited by high cost, limited space, interruptions to clinical duties, and the inability to replicate important nuances of clinical environments. We therefore sought to develop a reduced-cost low-space mobile cart to provide realistic simulation experiences to a range of providers within the clinical environment and to serve as a model for transportable, cost-effective, widespread simulation-based training of bona-fide workplace teams. Descriptive study. A tertiary care pediatric teaching hospital. A self-contained mobile simulation cart was constructed at a cost of $8054 (mannequin not included). The cart is compatible with any mannequin and contains all equipment needed to produce a high quality simulation experience equivalent to that of our on-site center--including didactics and debriefing with videotaped recordings complete with vital sign overlay. Over a 3-year period the cart delivered 57 courses to 425 participants from five pediatric departments. All individuals were trained among their native teams and within their own clinical environment. By bringing all pedagogical elements to the actual clinical environment, a mobile cart can provide simulation to hospital teams that might not otherwise benefit from the educational tool. By reducing the setup cost and the need for dedicated space, the mobile approach provides a mechanism to increase the number of institutions capable of harnessing the power of simulation-based education internationally.

  1. The nucleus accumbens 5-HTR₄-CART pathway ties anorexia to hyperactivity.

    Science.gov (United States)

    Jean, A; Laurent, L; Bockaert, J; Charnay, Y; Dusticier, N; Nieoullon, A; Barrot, M; Neve, R; Compan, V

    2012-12-11

    In mental diseases, the brain does not systematically adjust motor activity to feeding. Probably, the most outlined example is the association between hyperactivity and anorexia in Anorexia nervosa. The neural underpinnings of this 'paradox', however, are poorly elucidated. Although anorexia and hyperactivity prevail over self-preservation, both symptoms rarely exist independently, suggesting commonalities in neural pathways, most likely in the reward system. We previously discovered an addictive molecular facet of anorexia, involving production, in the nucleus accumbens (NAc), of the same transcripts stimulated in response to cocaine and amphetamine (CART) upon stimulation of the 5-HT(4) receptors (5-HTR(4)) or MDMA (ecstasy). Here, we tested whether this pathway predisposes not only to anorexia but also to hyperactivity. Following food restriction, mice are expected to overeat. However, selecting hyperactive and addiction-related animal models, we observed that mice lacking 5-HTR(1B) self-imposed food restriction after deprivation and still displayed anorexia and hyperactivity after ecstasy. Decryption of the mechanisms showed a gain-of-function of 5-HTR(4) in the absence of 5-HTR(1B), associated with CART surplus in the NAc and not in other brain areas. NAc-5-HTR(4) overexpression upregulated NAc-CART, provoked anorexia and hyperactivity. NAc-5-HTR(4) knockdown or blockade reduced ecstasy-induced hyperactivity. Finally, NAc-CART knockdown suppressed hyperactivity upon stimulation of the NAc-5-HTR(4). Additionally, inactivating NAc-5-HTR(4) suppressed ecstasy's preference, strengthening the rewarding facet of anorexia. In conclusion, the NAc-5-HTR(4)/CART pathway establishes a 'tight-junction' between anorexia and hyperactivity, suggesting the existence of a primary functional unit susceptible to limit overeating associated with resting following homeostasis rules.

  2. Turbine blade vibration dampening

    Science.gov (United States)

    Cornelius, C.C.; Pytanowski, G.P.; Vendituoli, J.S.

    1997-07-08

    The present turbine wheel assembly increases component life and turbine engine longevity. The combination of the strap and the opening combined with the preestablished area of the outer surface of the opening and the preestablished area of the outer circumferential surface of the strap and the friction between the strap and the opening increases the life and longevity of the turbine wheel assembly. Furthermore, the mass ``M`` or combined mass ``CM`` of the strap or straps and the centrifugal force assist in controlling vibrations and damping characteristics. 5 figs.

  3. Composite turbine bucket assembly

    Science.gov (United States)

    Liotta, Gary Charles; Garcia-Crespo, Andres

    2014-05-20

    A composite turbine blade assembly includes a ceramic blade including an airfoil portion, a shank portion and an attachment portion; and a transition assembly adapted to attach the ceramic blade to a turbine disk or rotor, the transition assembly including first and second transition components clamped together, trapping said ceramic airfoil therebetween. Interior surfaces of the first and second transition portions are formed to mate with the shank portion and the attachment portion of the ceramic blade, and exterior surfaces of said first and second transition components are formed to include an attachment feature enabling the transition assembly to be attached to the turbine rotor or disk.

  4. Prediction of radiation levels in residences: A methodological comparison of CART [Classification and Regression Tree Analysis] and conventional regression

    International Nuclear Information System (INIS)

    Janssen, I.; Stebbings, J.H.

    1990-01-01

    In environmental epidemiology, trace and toxic substance concentrations frequently have very highly skewed distributions ranging over one or more orders of magnitude, and prediction by conventional regression is often poor. Classification and Regression Tree Analysis (CART) is an alternative in such contexts. To compare the techniques, two Pennsylvania data sets and three independent variables are used: house radon progeny (RnD) and gamma levels as predicted by construction characteristics in 1330 houses; and ∼200 house radon (Rn) measurements as predicted by topographic parameters. CART may identify structural variables of interest not identified by conventional regression, and vice versa, but in general the regression models are similar. CART has major advantages in dealing with other common characteristics of environmental data sets, such as missing values, continuous variables requiring transformations, and large sets of potential independent variables. CART is most useful in the identification and screening of independent variables, greatly reducing the need for cross-tabulations and nested breakdown analyses. There is no need to discard cases with missing values for the independent variables because surrogate variables are intrinsic to CART. The tree-structured approach is also independent of the scale on which the independent variables are measured, so that transformations are unnecessary. CART identifies important interactions as well as main effects. The major advantages of CART appear to be in exploring data. Once the important variables are identified, conventional regressions seem to lead to results similar but more interpretable by most audiences. 12 refs., 8 figs., 10 tabs

  5. The costs and calorie content of à la carte food items purchased by students during school lunch

    Directory of Open Access Journals (Sweden)

    Betsey Ramirez

    2018-06-01

    Full Text Available School environments influence student food choices. À la carte foods and beverages are often low nutrient and energy dense. This study assessed how much money students spent for these foods, and the total kilocalories purchased per student during the 2012–2013 school year. Six elementary and four intermediate schools in the Houston area provided daily food purchase transaction data, and the cost and the calories for each item. Chi-square analysis assessed differences in the number of students purchasing à la carte items by grade level and school free/reduced-price meal (FRP eligibility. Analysis of covariance assessed grade level differences in cost and calories of weekly purchases, controlling for FRP eligibility. Intermediate grade students spent significantly more on à la carte food purchases and purchased more calories (both p < 0.001 than elementary school students. Lower socioeconomic status (SES elementary and intermediate school students purchased fewer à la carte foods compared to those in higher SES schools (p < 0.001. Intermediate school students purchased more à la carte foods and calories from à la carte foods than elementary students. Whether the new competitive food rules in schools improve student food selection and purchase, and dietary intake habits across all grade levels remains unknown. Keywords: National School Lunch Program, Elementary schools, Intermediate schools, À la carte foods, Competitive foods, Costs, Calories

  6. Bagging Approach for Increasing Classification Accuracy of CART on Family Participation Prediction in Implementation of Elderly Family Development Program

    Directory of Open Access Journals (Sweden)

    Wisoedhanie Widi Anugrahanti

    2017-06-01

    Full Text Available Classification and Regression Tree (CART was a method of Machine Learning where data exploration was done by decision tree technique. CART was a classification technique with binary recursive reconciliation algorithms where the sorting was performed on a group of data collected in a space called a node / node into two child nodes (Lewis, 2000. The aim of this study was to predict family participation in Elderly Family Development program based on family behavior in providing physical, mental, social care for the elderly. Family involvement accuracy using Bagging CART method was calculated based on 1-APER value, sensitivity, specificity, and G-Means. Based on CART method, classification accuracy was obtained 97,41% with Apparent Error Rate value 2,59%. The most important determinant of family behavior as a sorter was society participation (100,00000, medical examination (98,95988, providing nutritious food (68.60476, establishing communication (67,19877 and worship (57,36587. To improved the stability and accuracy of CART prediction, used CART Bootstrap Aggregating (Bagging with 100% accuracy result. Bagging CART classifies a total of 590 families (84.77% were appropriately classified into implement elderly Family Development program class.

  7. Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward.

    Science.gov (United States)

    Li, Jian; Li, Wenwen; Huang, Kejia; Zhang, Yang; Kupfer, Gary; Zhao, Qi

    2018-02-13

    Recently, the US Food and Drug Administration (FDA) approved the first chimeric antigen receptor T cell (CAR-T) therapy for the treatment CD19-positive B cell acute lymphoblastic leukemia. While CAR-T has achieved remarkable success in the treatment of hematopoietic malignancies, whether it can benefit solid tumor patients to the same extent is still uncertain. Even though hundreds of clinical trials are undergoing exploring a variety of tumor-associated antigens (TAA), no such antigen with comparable properties like CD19 has yet been identified regarding solid tumors CAR-T immunotherapy. Inefficient T cell trafficking, immunosuppressive tumor microenvironment, suboptimal antigen recognition specificity, and lack of safety control are currently considered as the main obstacles in solid tumor CAR-T therapy. Here, we reviewed the solid tumor CAR-T clinical trials, emphasizing the studies with published results. We further discussed the challenges that CAR-T is facing for solid tumor treatment and proposed potential strategies to improve the efficacy of CAR-T as promising immunotherapy.

  8. Acoustic noise production of wind turbines in practice

    International Nuclear Information System (INIS)

    Van der Borg, N.J.C.M.; Vink, P.W.

    1994-10-01

    Within the framework of national and European projects ECN has conducted various acoustic noise measurements on wind turbines. The measurements can be divided into the following two categories: (1) measurements of the total noise emitted by the turbine ('standard measurements') and (2) measurement of the noise emitted by different blades on the same rotor ('research measurements'). The applied procedures for the 'standard measurements' are given in IEA and IEC documents on wind turbine noise measurements. The applied procedures for the 'research measurements' are given in this paper. General results obtained with both kind of measurements are presented. The 'research measurements' have been performed on a limited number of turbines: the UNIWEX turbine in Germany and a commercial turbine in The Netherlands. The turbines were equipped with differently shaped blade tips or trailing edges on the same rotor. The experiments showed no large differences in the sound production of the different blades on the same rotor. The detailed information on the commercial wind turbine in The Netherlands is confidential. 9 figs., 2 tabs., 3 refs

  9. Cocaine- and amphetamine-regulated transcript (CART signaling within the paraventricular thalamus modulates cocaine-seeking behaviour.

    Directory of Open Access Journals (Sweden)

    Morgan H James

    Full Text Available BACKGROUND: Cocaine- and amphetamine-regulated transcript (CART has been demonstrated to play a role in regulating the rewarding and reinforcing effects of various drugs of abuse. A recent study demonstrated that i.c.v. administration of CART negatively modulates reinstatement of alcohol seeking, however, the site(s of action remains unclear. We investigated the paraventricular thalamus (PVT as a potential site of relapse-relevant CART signaling, as this region is known to receive dense innervation from CART-containing hypothalamic cells and to project to a number of regions known to be involved in mediating reinstatement, including the nucleus accumbens (NAC, medial prefrontal cortex (mPFC and basolateral amygdala (BLA. METHODOLOGY/PRINCIPAL FINDINGS: Male rats were trained to self-administer cocaine before being extinguished to a set criterion. One day following extinction, animals received intra-PVT infusions of saline, tetrodotoxin (TTX; 2.5 ng, CART (0.625 µg or 2.5 µg or no injection, followed by a cocaine prime (10 mg/kg, i.p.. Animals were then tested under extinction conditions for one hour. Treatment with either TTX or CART resulted in a significant attenuation of drug-seeking behaviour following cocaine-prime, with the 2.5 µg dose of CART having the greatest effect. This effect was specific to the PVT region, as misplaced injections of both TTX and CART resulted in responding that was identical to controls. CONCLUSIONS/SIGNIFICANCE: We show for the first time that CART signaling within the PVT acts to inhibit drug-primed reinstatement of cocaine seeking behaviour, presumably by negatively modulating PVT efferents that are important for drug seeking, including the NAC, mPFC and BLA. In this way, we identify a possible target for future pharmacological interventions designed to suppress drug seeking.

  10. Evaluation of CART peptide level in rat plasma and CSF: Possible role as a biomarker in opioid addiction.

    Science.gov (United States)

    Bakhtazad, Atefeh; Vousooghi, Nasim; Garmabi, Behzad; Zarrindast, Mohammad Reza

    2016-10-01

    It has been shown previously that cocaine- and amphetamine-regulated transcript (CART) peptide has a modulatory role and homeostatic regulatory effect in motivation to and reward of the drugs of abuse specially psychostimulants. Recent data also showed that in addition to psychostimulants, CART is critically involved in the different stages of opioid addiction. Here we have evaluated the fluctuations in the level of CART peptide in plasma and CSF in different phases of opioid addiction to find out whether CART can serve as a suitable marker in opioid addiction studies. Male rats were randomly distributed in groups of control, acute low-dose (10mg/kg) morphine, acute high-dose morphine (80mg/kg), chronic escalating doses of morphine, withdrawal syndrome precipitated by administration of naloxone (1mg/kg), and abstinent after long-term drug-free maintenance of addicted animals. The level of CART peptide in CSF and plasma samples was measured by enzyme immunoassay. CART peptide concentration in the CSF and plasma was significantly elevated in acute high-dose morphine and withdrawal state animals and down-regulated in addicted rats. In abstinent group, CART peptide level was up-regulated in plasma but not in CSF samples. As the observed results are in agreement with data regarding the CART mRNA and protein expression in the brain reward pathway in opioid addiction phases, it may be suggested that evaluation of CART peptide level in CSF or plasma could be a suitable marker which reflects the rises and falls of the peptide concentration in brain in the development of opioid addiction. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Increase in cocaine- and amphetamine-regulated transcript (CART) in specific areas of the mouse brain by acute caffeine administration.

    Science.gov (United States)

    Cho, Jin Hee; Cho, Yun Ha; Kim, Hyo Young; Cha, Seung Ha; Ryu, Hyun; Jang, Wooyoung; Shin, Kyung Ho

    2015-04-01

    Caffeine produces a variety of behavioral effects including increased alertness, reduced food intake, anxiogenic effects, and dependence upon repeated exposure. Although many of the effects of caffeine are mediated by its ability to block adenosine receptors, it is possible that other neural substrates, such as cocaine- and amphetamine-regulated transcript (CART), may be involved in the effects of caffeine. Indeed, a recent study demonstrated that repeated caffeine administration increases CART in the mouse striatum. However, it is not clear whether acute caffeine administration alters CART in other areas of the brain. To explore this possibility, we investigated the dose- and time-dependent changes in CART immunoreactivity (CART-IR) after a single dose of caffeine in mice. We found that a high dose of caffeine (100 mg/kg) significantly increased CART-IR 2 h after administration in the nucleus accumbens shell (AcbSh), dorsal bed nucleus of the stria terminalis (dBNST), central nucleus of the amygdala (CeA), paraventricular hypothalamic nucleus (PVN), arcuate hypothalamic nucleus (Arc), and locus coeruleus (LC), and returned to control levels after 8 h. But this increase was not observed in other brain areas. In addition, caffeine administration at doses of 25 and 50 mg/kg appears to produce dose-dependent increases in CART-IR in these brain areas; however, the magnitude of increase in CART-IR observed at a dose of 50 mg/kg was similar or greater than that observed at a dose of 100 mg/kg. This result suggests that CART-IR in AcbSh, dBNST, CeA, PVN, Arc, and LC is selectively affected by caffeine administration. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Chromatin immunoprecipitation assays revealed CREB and serine 133 phospho-CREB binding to the CART gene proximal promoter.

    Science.gov (United States)

    Rogge, George A; Shen, Li-Ling; Kuhar, Michael J

    2010-07-16

    Both over expression of cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc), and intra-accumbal injection of cocaine- and amphetamine-regulated transcript (CART) peptides, have been shown to decrease cocaine reward. Also, over expression of CREB in the rat NAc increased CART mRNA and peptide levels, but it is not known if this was due to a direct action of P-CREB on the CART gene promoter. The goal of this study was to test if CREB and P-CREB bound directly to the CRE site in the CART promoter, using chromatin immunoprecipitation (ChIP) assays. ChIP assay with anti-CREB antibodies showed an enrichment of the CART promoter fragment containing the CRE region over IgG precipitated material, a non-specific control. Forskolin, which was known to increase CART mRNA levels in GH3 cells, was utilized to show that the drug increased levels of P-CREB protein and P-CREB binding to the CART promoter CRE-containing region. A region of the c-Fos promoter containing a CRE cis-regulatory element was previously shown to bind P-CREB, and it was used here as a positive control. These data suggest that the effects of CREB over expression on blunting cocaine reward could be, at least in part, attributed to the increased expression of the CART gene by direct interaction of P-CREB with the CART promoter CRE site, rather than by some indirect action. Copyright (c) 2010 Elsevier B.V. All rights reserved.

  13. 变速变桨风力机组控制策略研究%Research on the Control Strategy for Variable Speed and Variable Pitch Wind Turbine

    Institute of Scientific and Technical Information of China (English)

    陈铁军; 汪兆财

    2012-01-01

    In order to increase the utilization efficiency of wind energy of wind turbine power generation system, and improve the quality of output electric energy, with the chaotic system theory as the core, the control structure of chaotic automation used for variable speed and variable pitch wind turbine is established. In addition, combining with fuzzy control theory, the algorithm of controller is given. The simulation of the control structure and control algorithm shows that comparing with conventional control method, the variable speed and variable pitch wind turbine with chaotic automation control structure and under control algorithm reaches predicted target, the practical control effect is excellent.%为提高风力机发电系统的风能利用效率、改善输出电能质量,针对变速变桨风力发电机组的控制问题,以混杂系统理论为核心,建立了应用于变速变桨风力机组的混杂自动机控制结构.同时,结合模糊控制理论,给出控制器的算法.通过对该控制结构和控制算法的仿真表明,与常规的控制方法相比,采用混杂自动机控制结构和控制算法控制变速变桨风力机组,既提高了风能的利用效率,又很好地改善了风力机输出电能质量,实际控制效果良好.

  14. Superconducting wind turbine generators

    DEFF Research Database (Denmark)

    Abrahamsen, Asger Bech; Mijatovic, Nenad; Seiler, Eugen

    2010-01-01

    , the main challenge of the superconducting direct drive technology is to prove that the reliability is superior to the alternative drive trains based on gearboxes or permanent magnets. A strategy of successive testing of superconducting direct drive trains in real wind turbines of 10 kW, 100 kW, 1 MW and 10......We have examined the potential of 10 MW superconducting direct drive generators to enter the European offshore wind power market and estimated that the production of about 1200 superconducting turbines until 2030 would correspond to 10% of the EU offshore market. The expected properties of future...... offshore turbines of 8 and 10 MW have been determined from an up-scaling of an existing 5 MW turbine and the necessary properties of the superconducting drive train are discussed. We have found that the absence of the gear box is the main benefit and the reduced weight and size is secondary. However...

  15. Turbine disintegration debris

    International Nuclear Information System (INIS)

    Holecek, M.; Martinec, P.; Malotin, V.; Peleska, P.; Voldrich, J.

    1997-01-01

    The determination, evaluation and analysis of possible unacceptable consequences of the disintegration turbine (turbo-set) missiles is a part of the wide conceived project put by the company Nuclear Power Plant Mochovce (NPPM), the Slovak Republic. The aim of the project is to take measures reducing the probability of striking a target of safety importance in NPPM by a turbine (turbo-set) missile below the prescribed limit of 10 -6 per turbine year. Following the IAEA Safety Guides, all potential events leading to the generation of a missile are to be analysed. It is necessary to evaluate the probability of unacceptable consequences of such missiles and analyse each event whose probability is not acceptable low. This complex problem thus carries especially: complex analysis of fragment generation; evaluation of the probability of unacceptable events; location of strike zones of possible turbine missiles; assessment the possibility of the turbo-set casing penetration; and projection of additional design requirements if necessary

  16. Monitoring of wind turbines

    Science.gov (United States)

    White, Jonathan R.; Adams, Douglas E.; Paquette, Josh

    2017-07-25

    Method and apparatus for determining the deflection or curvature of a rotating blade, such as a wind turbine blade or a helicopter blade. Also, methods and apparatus for establishing an inertial reference system on a rotating blade.

  17. Innovative multi rotor wind turbine designs

    Energy Technology Data Exchange (ETDEWEB)

    Kale, S.A.; Sapali, S.N. [College of Engineering. Mechanical Engineering Dept, Pune (India)

    2012-07-01

    Among the renewable energy sources, today wind energy is the most recognized and cost effective. Developers and researchers in this sector are optimistic and continuously working innovatively to improve the technology. The wind power obtained is proportional to the swept area of wind turbine. The swept area is increased by using a single rotor of large diameter or multi rotors in array. The rotor size is growing continuously with mature technology. Multi rotor technology has a long history and the multi rotor concept persists in a variety of modern innovative systems but the concept has fallen out of consideration in mainstream design from the perception that is complex and unnecessary as very large single rotor units are now technically feasible. This work addresses the evaluation of different multi rotor wind turbine systems. These innovative wind turbines are evaluated on the basis of feasibility, technological advantages, security of expected power performance, cost, reliability, impact of innovative system, comparison with existing wind turbine design. The findings of this work will provide guidelines for the practical and economical ways for further research on the multi rotor wind turbines. (Author)

  18. Comparison of four large-eddy simulation research codes and effects of model coefficient and inflow turbulence in actuator-line-based wind turbine modeling

    DEFF Research Database (Denmark)

    Martínez-Tossas, Luis A.; Churchfield, Matthew J.; Yilmaz, Ali Emre

    2018-01-01

    to match closely for all codes. The value of the Smagorinsky coefficient in the subgrid-scale turbulence model is shown to have a negligible effect on the time-averaged loads along the blades. Conversely, the breakdown location of the wake is strongly dependent on the Smagorinsky coefficient in uniform...... coefficient has a negligible effect on the wake profiles. It is concluded that for LES of wind turbines and wind farms using ALM, careful implementation and extensive cross-verification among codes can result in highly reproducible predictions. Moreover, the characteristics of the inflow turbulence appear...

  19. Noise from wind turbines

    Energy Technology Data Exchange (ETDEWEB)

    Fegeant, Olivier [Royal Inst. of Tech., Stockholm (Sweden). Dept. of Building Sciences

    2002-02-01

    A rapid growth of installed wind power capacity is expected in the next few years. However, the siting of wind turbines on a large scale raises concerns about their environmental impact, notably with respect to noise. To this end, variable speed wind turbines offer a promising solution for applications in densely populated areas like the European countries, as this design would enable an efficient utilisation of the masking effect due to ambient noise. In rural and recreational areas where wind turbines are sited, the ambient noise originates from the action of wind on the vegetation and about the listener's ear (pseudo-noise). It shows a wind speed dependence similar to that of the noise from a variable speed wind turbine and can therefore mask the latter for a wide range of conditions. However, a problem inherent to the design of these machines is their proclivity to pure tone generation, because of the enhanced difficulty of avoiding structural resonances in the mechanical parts. Pure tones are deemed highly annoying and are severely regulated by most noise policies. In relation to this problem, the vibration transmission of structure-borne sound to the tower of the turbine is investigated, in particular when the tower is stiffened at its upper end. Furthermore, since noise annoyance due to wind turbine is mostly a masking issue, the wind-related sources of ambient noise are studied and their masking potentials assessed. With this aim, prediction models for wind-induced vegetation noise and pseudo-noise have been developed. Finally, closely related to the effect of masking, is the difficulty, regularly encountered by local authorities and wind farm developers, to measure noise immission from wind turbines. A new measurement technique has thus been developed in the course of this work. Through improving the signal-to-noise ratio between wind turbine noise and ambient noise, the new technique yields more accurate measurement results.

  20. Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer.

    Science.gov (United States)

    Hege, Kristen M; Bergsland, Emily K; Fisher, George A; Nemunaitis, John J; Warren, Robert S; McArthur, James G; Lin, Andy A; Schlom, Jeffrey; June, Carl H; Sherwin, Stephen A

    2017-01-01

    T cells engineered to express chimeric antigen receptors (CARs) have established efficacy in the treatment of B-cell malignancies, but their relevance in solid tumors remains undefined. Here we report results of the first human trials of CAR-T cells in the treatment of solid tumors performed in the 1990s. Patients with metastatic colorectal cancer (CRC) were treated in two phase 1 trials with first-generation retroviral transduced CAR-T cells targeting tumor-associated glycoprotein (TAG)-72 and including a CD3-zeta intracellular signaling domain (CART72 cells). In trial C-9701 and C-9702, CART72 cells were administered in escalating doses up to 10 10 total cells; in trial C-9701 CART72 cells were administered by intravenous infusion. In trial C-9702, CART72 cells were administered via direct hepatic artery infusion in patients with colorectal liver metastases. In both trials, a brief course of interferon-alpha (IFN-α) was given with each CART72 infusion to upregulate expression of TAG-72. Fourteen patients were enrolled in C-9701 and nine in C-9702. CART72 manufacturing success rate was 100% with an average transduction efficiency of 38%. Ten patients were treated in CC-9701 and 6 in CC-9702. Symptoms consistent with low-grade, cytokine release syndrome were observed in both trials without clear evidence of on target/off tumor toxicity. Detectable, but mostly short-term (≤14 weeks), persistence of CART72 cells was observed in blood; one patient had CART72 cells detectable at 48 weeks. Trafficking to tumor tissues was confirmed in a tumor biopsy from one of three patients. A subset of patients had 111 Indium-labeled CART72 cells injected, and trafficking could be detected to liver, but T cells appeared largely excluded from large metastatic deposits. Tumor biomarkers carcinoembryonic antigen (CEA) and TAG-72 were measured in serum; there was a precipitous decline of TAG-72, but not CEA, in some patients due to induction of an interfering antibody to the TAG-72

  1. Substance use and adherence among people living with HIV/AIDS receiving cART in Latin America

    OpenAIRE

    De Boni, Raquel B.; Shepherd, Bryan E.; Grinsztejn, Beatriz; Cesar, Carina; Cortés, Claudia; Padgett, Denis; Gotuzzo, Eduardo; Belaunzarán-Zamudio, Pablo F.; Rebeiro, Peter F.; Duda, Stephany N.; McGowan, Catherine C.

    2016-01-01

    This cross-sectional study describes substance use prevalence and its association with cART adherence among 3343 individuals receiving care at HIV clinics in Argentina, Brazil, Chile, Honduras, Mexico, and Peru. A rapid screening tool evaluated self-reported 7-day recall of alcohol, marijuana, cocaine, heroin, and methamphetamine use, and missed cART doses. Overall, 29.3% individuals reported having ≥ 1 alcoholic drinks, 5.0% reported any illicit drug use and 17.0% reported missed cART doses....

  2. Etiologies of pediatric craniofacial injuries: a comparison of injuries involving all-terrain vehicles and golf carts.

    Science.gov (United States)

    White, Lauren C; McKinnon, Brian J; Hughes, C Anthony

    2013-03-01

    To determine incidence and etiologies of craniofacial injuries in the pediatric population through comparison of injuries caused by all-terrain vehicles and golf cart trauma. Case series with chart review. Level 1 trauma center. Retrospective review of pediatric traumas at a tertiary academic medical center from 2003 to 2012 identified 196 patients whose injuries resulted from accidents involving either all-terrain vehicles or golf carts. Data was collected and variables such as age, gender, driver vs. passenger, location of accident, Glasgow coma scale, Injury severity scale, Abbreviated injury scale, and presence or absence of helmet use were examined. 196 pediatric patients were identified: 68 patients had injuries resulting from golf cart accidents, and 128 patients from ATV accidents. 66.4% of ATV-related traumas were male, compared to 52.9% of golf cart-related traumas. Ages of injured patients were similar between the two modalities with average age of ATV traumas 10.8 (±4.0) years and golf cart traumas 10.0 (±4.6) years. Caucasians were most commonly involved in both ATV (79.7%) and golf cart traumas (85.3%). 58.6% of all ATV related trauma and 69.1% of all golf cart trauma resulted in craniofacial injuries. The most common craniofacial injury was a closed head injury with brief loss of consciousness, occurring in 46.1% of the ATV traumas and 54.4% of the golf cart traumas. Temporal bone fractures were the second most common type of craniofacial injury, occurring in 5.5% of ATV accidents and 7.4% of the golf cart traumas. Length of hospital stay and, cases requiring surgery and severity scores were similar between both populations. Intensive care admissions and injury severity scores approached but not reach statistical significance (0.096 and 0.083, respectively). The only statistically significant differences between the two modalities were helmet use (P=0.00018%) and days requiring ventilator assistance (P=0.025). ATVs and golf carts are often exempt

  3. EL PRECURSOR DEL NEUROPEPTIDO CART POSEE UNA SEÑAL DE DESTINACION A LAS VESICULAS DE SECRECION REGULADA

    OpenAIRE

    BLANCO NAHUELQUEO, ELIAS HUMBERTO; BLANCO NAHUELQUEO, ELIAS HUMBERTO

    2011-01-01

    CART (Cocaine- Amphetamine Regulated Transcript} fue descubierto como un RNAm que es inducido por una dosis aguda de cocaína y también de anfetamina en el estriado de cerebro de rata. A partir de su descubrimiento el neuropéptido CART fue vinculado a drogas de abuso, sin embargo existe mayor evidencia que lo vincula al control del apetito. El neuropéptido CART inhibe potentemente el apetito (efecto anorexigénico} cuando es administrado intra-cerebralmente a roedores. Una subregión de...

  4. Wind turbines: is there a human health risk?

    Science.gov (United States)

    Roberts, Jennifer D; Roberts, Mark A

    2013-04-01

    The term "Wind Turbine Syndrome" was coined in a recently self-published book, which hypothesized that a multitude of symptoms such as headache and dizziness resulted from wind turbines generating low frequency sound (LFS). The objective of this article is to provide a summary of the peer-reviewed literature on the research that has examined the relationship between human health effects and exposure to LFS and sound generated from the operation of wind turbines. At present, a specific health condition has not been documented in the peer-reviewed literature that has been classified as a disease caused by exposure to sound levels and frequencies generated by the operation of wind turbines. Communities are experiencing a heightened sense of annoyance and fear from the development and siting of wind turbine farms. High-quality research and effective risk communication can advance this course from one of panic to one of understanding and exemplification for other environmental advancements.

  5. European wind turbine catalogue

    International Nuclear Information System (INIS)

    1994-01-01

    The THERMIE European Community programme is designed to promote the greater use of European technology and this catalogue contributes to the fulfillment of this aim by dissemination of information on 50 wind turbines from 30 manufacturers. These turbines are produced in Europe and are commercially available. The manufacturers presented produce and sell grid-connected turbines which have been officially approved in countries where this approval is acquired, however some of the wind turbines included in the catalogue have not been regarded as fully commercially available at the time of going to print. The entries, which are illustrated by colour photographs, give company profiles, concept descriptions, measured power curves, prices, and information on design and dimension, safety systems, stage of development, special characteristics, annual energy production, and noise pollution. Lists are given of wind turbine manufacturers and agents and of consultants and developers in the wind energy sector. Exchange rates used in the conversion of the prices of wind turbines are also given. Information can be found on the OPET network (organizations recognised by the European Commission as an Organization for the Promotion of Energy Technologies (OPET)). An article describes the development of the wind power industry during the last 10-15 years and another article on certification aims to give an overview of the most well-known and acknowledged type approvals currently issued in Europe. (AB)

  6. Wind turbines and infrasound

    International Nuclear Information System (INIS)

    Howe, B.

    2006-01-01

    This paper provided the results of a study conducted to assess the impacts of wind farm-induced infrasound on nearby residences and human populations. Infrasound occurs at frequencies below those considered as detectable by human hearing. Infrasonic levels caused by wind turbines are often similar to ambient levels of 85 dBG or lower that are caused by wind in the natural environment. This study examined the levels at which infrasound poses a threat to human health or can be considered as an annoyance. The study examined levels of infrasound caused by various types of wind turbines, and evaluated acoustic phenomena and characteristics associated with wind turbines. Results of the study suggested that infrasound near modern wind turbines is typically not perceptible to humans through either auditory or non-auditory mechanisms. However, wind turbines often create an audible broadband noise whose amplitude can be modulated at low frequencies. A review of both Canadian and international studies concluded that infrasound generated by wind turbines should not significantly impact nearby residences or human populations. 17 refs., 2 tabs., 4 figs

  7. Hybrid Turbine Electric Vehicle

    Science.gov (United States)

    Viterna, Larry A.

    1997-01-01

    Hybrid electric power trains may revolutionize today's ground passenger vehicles by significantly improving fuel economy and decreasing emissions. The NASA Lewis Research Center is working with industry, universities, and Government to develop and demonstrate a hybrid electric vehicle. Our partners include Bowling Green State University, the Cleveland Regional Transit Authority, Lincoln Electric Motor Division, the State of Ohio's Department of Development, and Teledyne Ryan Aeronautical. The vehicle will be a heavy class urban transit bus offering double the fuel economy of today's buses and emissions that are reduced to 1/10th of the Environmental Protection Agency's standards. At the heart of the vehicle's drive train is a natural-gas-fueled engine. Initially, a small automotive engine will be tested as a baseline. This will be followed by the introduction of an advanced gas turbine developed from an aircraft jet engine. The engine turns a high-speed generator, producing electricity. Power from both the generator and an onboard energy storage system is then provided to a variable-speed electric motor attached to the rear drive axle. An intelligent power-control system determines the most efficient operation of the engine and energy storage system.

  8. Onshore industrial wind turbine locations for the United States up to March 2014

    Science.gov (United States)

    Diffendorfer, James E.; Kramer, Louisa; Ancona, Zachary H.; Garrity, Christopher P.

    2015-01-01

    Wind energy is a rapidly growing form of renewable energy in the United States. While summary information on the total amounts of installed capacity are available by state, a free, centralized, national, turbine-level, geospatial dataset useful for scientific research, land and resource management, and other uses did not exist. Available in multiple formats and in a web application, these public domain data provide industrial-scale onshore wind turbine locations in the United States up to March 2014, corresponding facility information, and turbine technical specifications. Wind turbine records have been collected and compiled from various public sources, digitized or position verified from aerial imagery, and quality assured and quality controlled. Technical specifications for turbines were assigned based on the wind turbine make and model as described in public literature. In some cases, turbines were not seen in imagery or turbine information did not exist or was difficult to obtain. Uncertainty associated with these is recorded in a confidence rating.

  9. Onshore industrial wind turbine locations for the United States up to March 2014.

    Science.gov (United States)

    Diffendorfer, Jay E; Kramer, Louisa A; Ancona, Zach H; Garrity, Christopher P

    2015-11-24

    Wind energy is a rapidly growing form of renewable energy in the United States. While summary information on the total amounts of installed capacity are available by state, a free, centralized, national, turbine-level, geospatial dataset useful for scientific research, land and resource management, and other uses did not exist. Available in multiple formats and in a web application, these public domain data provide industrial-scale onshore wind turbine locations in the United States up to March 2014, corresponding facility information, and turbine technical specifications. Wind turbine records have been collected and compiled from various public sources, digitized or position verified from aerial imagery, and quality assured and quality controlled. Technical specifications for turbines were assigned based on the wind turbine make and model as described in public literature. In some cases, turbines were not seen in imagery or turbine information did not exist or was difficult to obtain. Uncertainty associated with these is recorded in a confidence rating.

  10. Emerging immunotherapeutics in adenocarcinomas: A focus on CAR-T cells.

    Science.gov (United States)

    Yazdanifar, Mahboubeh; Zhou, Ru; Mukherjee, Pinku

    2016-01-01

    More than 80% of all cancers arise from epithelial cells referred to as carcinomas. Adenocarcinomas are the most common type of carcinomas arising from the specialized epithelial cells that line the ducts of our major organs. Despite many advances in cancer therapies, metastatic and treatment-refractory cancers remain the 2 nd leading cause of death. Immunotherapy has offered potential opportunities with specific targeting of tumor cells and inducing remission in many cancer patients. Numerous therapies using antibodies as antagonists or checkpoint inhibitors/immune modulators, peptide or cell vaccines, cytokines, and adoptive T cell therapies have been developed. The most innovative immunotherapy approach so far has been the use of engineered T cell, also referred to as chimeric antigen receptor T cells (CAR-T cells). CAR-T cells are genetically modified naïve T cells that express a chimeric molecule which comprises of the antigen-recognition domains (scFv) of an anti-tumor antibody and one, two, or three intracellular signaling domains of the T cell receptor (TCR). When these engineered T cells recognize and bind to the tumor antigen target via the scFv fragment, a signal is sent to the intracellular TCR domains of the CAR, leading to activation of the T cells to become cytolytic against the tumor cells. CAR-T cell therapy has shown tremendous success for certain hematopoietic malignancies, but this success has not been extrapolated to adenocarcinomas. This is due to multiple factors associated with adenocarcinoma that are different from hematopoietic tumors. Although many advances have been made in targeting multiple cancers by CAR-T cells, clinical trials have shown adverse effects and toxicity related to this treatment. New strategies are yet to be devised to manage side effects associated with CAR-T cell therapies. In this review, we report some of the promising immunotherapeutic strategies being developed for treatment of most common adenocarcinomas with

  11. The Research on Second-Order ADRC Algorithm of Using Wind Turbine Virtual Inertia to Participate in Primary Frequency Regulation in a Small Stand-Alone Microgrid

    Directory of Open Access Journals (Sweden)

    Wang Yi

    2018-01-01

    Full Text Available In order to improve the transient stability of frequency in a small stand-alone microgrid (SSM, this paper takes a SSM composed of a direct-drive permanent magnet synchronous generator (D-PMSG and a micro gas turbine (MGT as the background and uses wind turbine generator (WTG virtual inertia (VI to participate in the primary (short-term system frequency regulation. First of all, this paper constructs a grid-connected model composed of a WTG and a MGT, analyzes the WTG virtual inertia frequency regulation mechanism, and explains the principle of proportional-differentiation (PD virtual inertia control (VIC and its shortcomings. Secondly, the paper introduces the structure principle of n-order active disturbance rejection control (ADRC and deduces the design process of second-order ADRC-VIC. Finally, through the simulation and experimental verification, comparing the frequency perturbation of without-VIC, PD-VIC, and ADRC-VIC, it is concluded that PD-VIC and ADRC-VIC both can use the WTG virtual inertia to participate in the primary frequency regulation. The frequency regulation effect of ADRC-VIC is better than PD-VIC, ADRC-VIC can extend the rotor speed recovery time and avoid overshoot, and its frequency fluctuation amplitude and settling time are obviously improved, and ADRC-VIC can effectively avoid the overshoot phenomenon of the MGT output power.

  12. Turbine shovels - research from the viewpoint of a safe work at nominal and increased individual power of turbo-generator sets

    International Nuclear Information System (INIS)

    Kachurkov, Gjorgji

    1995-01-01

    The secure work of the shovel devices is an important condition for a long and safe work. The steam turbine shovels are the most important and expensive elements. The damages of this elements can be very dangerous for the equipment as well as for the people. A long and expensive break of the work could be needed to repair them. All the shovels work in difficult conditions, but the first and the last stages work in the most difficult conditions. The working shovels of the first stages are influenced by a high parameter steam and during the partial bringing up of the steam the shovel load changes several times for every turbine turn from maximum to zero. The working shovels of the last stages are exposed to bending forces caused by the steam flow, as well as to strong centrifugal forces and to erosion effect as a result of a higher humidity and speed. The erosion of the shovel inlet edge can bring both pores and cracks appearance as a result of tension concentrations in the relatively thin edges. (author).7 figs., 1 ill

  13. Wind turbines and idiopathic symptoms

    DEFF Research Database (Denmark)

    Blanes-Vidal, Victoria; Schwartz, Joel

    2016-01-01

    Whether or not wind turbines pose a risk to human health is a matter of heated debate. Personal reactions to other environmental exposures occurring in the same settings as wind turbines may be responsible of the reported symptoms. However, these have not been accounted for in previous studies. We...... investigated whether there is an association between residential proximity to wind turbines and idiopathic symptoms, after controlling for personal reactions to other environmental co-exposures. We assessed wind turbine exposures in 454 residences as the distance to the closest wind turbine (Dw) and number...... of wind turbines

  14. Bird collision impacts at wind turbines in eastern North America

    Energy Technology Data Exchange (ETDEWEB)

    Kerlinger, Paul; Curry, Richard; Guarnaccia, John [Curry and Kerlinger, LLC (United States)

    2011-07-01

    This paper discusses the incidence of bird collisions at wind turbines in Eastern North America. Modern wind turbines are high, with long, tubular towers. Bird fatality is analyzed and references to the relevant studies that have been done are given. 26 sites were investigated for turbine mortality in 2011 and these are shown on a map. 64 turbines were examined in Maple Ridge and it was seen that 4 birds were killed per turbine per year. The results demonstrated that no eagles were killed, there were no endangered species involved and there was no real deviation from site to site. More than 80,000 individual turbines were researched and more than $30 million spent on the study. Around 120,000 birds are killed per year, or an average of over 6 birds per turbine per year, in the United States. It is clear from the extensive research conducted that there are a lot of data on birds and turbines; the data show that songbirds are the most often affected.

  15. Efficiency limit factor analysis for the Francis-99 hydraulic turbine

    Science.gov (United States)

    Zeng, Y.; Zhang, L. X.; Guo, J. P.; Guo, Y. K.; Pan, Q. L.; Qian, J.

    2017-01-01

    The energy loss in hydraulic turbine is the most direct factor that affects the efficiency of the hydraulic turbine. Based on the analysis theory of inner energy loss of hydraulic turbine, combining the measurement data of the Francis-99, this paper calculates characteristic parameters of inner energy loss of the hydraulic turbine, and establishes the calculation model of the hydraulic turbine power. Taken the start-up test conditions given by Francis-99 as case, characteristics of the inner energy of the hydraulic turbine in transient and transformation law are researched. Further, analyzing mechanical friction in hydraulic turbine, we think that main ingredients of mechanical friction loss is the rotation friction loss between rotating runner and water body, and defined as the inner mechanical friction loss. The calculation method of the inner mechanical friction loss is given roughly. Our purpose is that explore and research the method and way increasing transformation efficiency of water flow by means of analysis energy losses in hydraulic turbine.

  16. A review of damage detection methods for wind turbine blades

    International Nuclear Information System (INIS)

    Li, Dongsheng; Song, Gangbing; Ren, Liang; Li, Hongnan; Ho, Siu-Chun M

    2015-01-01

    Wind energy is one of the most important renewable energy sources and many countries are predicted to increase wind energy portion of their whole national energy supply to about twenty percent in the next decade. One potential obstacle in the use of wind turbines to harvest wind energy is the maintenance of the wind turbine blades. The blades are a crucial and costly part of a wind turbine and over their service life can suffer from factors such as material degradation and fatigue, which can limit their effectiveness and safety. Thus, the ability to detect damage in wind turbine blades is of great significance for planning maintenance and continued operation of the wind turbine. This paper presents a review of recent research and development in the field of damage detection for wind turbine blades. Specifically, this paper reviews frequently employed sensors including fiber optic and piezoelectric sensors, and four promising damage detection methods, namely, transmittance function, wave propagation, impedance and vibration based methods. As a note towards the future development trend for wind turbine sensing systems, the necessity for wireless sensing and energy harvesting is briefly presented. Finally, existing problems and promising research efforts for online damage detection of turbine blades are discussed. (topical review)

  17. Design and development of nautilus whorl-wind turbine

    Science.gov (United States)

    R, Pramod; Kumar, G. B. Veeresh; Harsha, P. Sai Sri; Kumar, K. A. Udaya

    2017-07-01

    Our life is directly related to energy and its consumption, and the issues of energy research are extremely important and highly sensitive. Scientists and researchers attempt to accelerate solutions for wind energy generation, design parameters under the influence of novel policies adopted for energy management and the concerns for global warming and climate change. The objective of this study is to design a small wind turbine that is optimized for the constraints that come with residential use. The study is aimed at designing a wind turbine for tapping the low speed wind in urban locations. The design process includes the selection of the wind turbine type and the determination of the blade airfoil, finding the maximum drag model and manufacturing of the turbine economically. In this study, the Nautilus turbine is modeled, simulated and the characteristic curves are plotted. The cutting in wind speed for the turbine is around 1m/s. The turbine rotates in a range of 20 rpm to 500 rpm at wind speeds 1m/s to 10m/s On a below average day at noon where the wind speed are usually low the turbine recorded an rpm of 120 (average value) at 4m/s wind speeds. This study focuses on a computational fluid dynamics analysis of compressible radially outward flow.

  18. Sandia SWiFT Wind Turbine Manual.

    Energy Technology Data Exchange (ETDEWEB)

    White, Jonathan; LeBlanc, Bruce Philip; Berg, Jonathan Charles; Bryant, Joshua; Johnson, Wesley D.; Paquette, Joshua

    2016-01-01

    The Scaled Wind Farm Technology (SWiFT) facility, operated by Sandia National Laboratories for the U.S. Department of Energy's Wind and Water Power Program, is a wind energy research site with multiple wind turbines scaled for the experimental study of wake dynamics, advanced rotor development, turbine control, and advanced sensing for production-scale wind farms. The SWiFT site currently includes three variable-speed, pitch-regulated, three-bladed wind turbines. The six volumes of this manual provide a detailed description of the SWiFT wind turbines, including their operation and user interfaces, electrical and mechanical systems, assembly and commissioning procedures, and safety systems. Further dissemination only as authorized to U.S. Government agencies and their contractors; other requests shall be approved by the originating facility or higher DOE programmatic authority. 111 UNCLASSIFIED UNLIMITED RELEASE Sandia SWiFT Wind Turbine Manual (SAND2016-0746 ) approved by: Department Manager SWiFT Site Lead Dave Minster (6121) Date Jonathan White (6121) Date SWiFT Site Supervisor Dave Mitchell (6121) Date Note: Document revision logs are found after the title page of each volume of this manual. iv

  19. Overview of Advanced Turbine Systems Program

    Science.gov (United States)

    Webb, H. A.; Bajura, R. A.

    The US Department of Energy initiated a program to develop advanced gas turbine systems to serve both central power and industrial power generation markets. The Advanced Turbine Systems (ATS) Program will lead to commercial offerings by the private sector by 2002. ATS will be developed to fire natural gas but will be adaptable to coal and biomass firing. The systems will be: highly efficient (15 percent improvement over today's best systems); environmentally superior (10 percent reduction in nitrogen oxides over today's best systems); and cost competitive (10 percent reduction in cost of electricity). The ATS Program has five elements. Innovative cycle development will lead to the demonstration of systems with advanced gas turbine cycles using current gas turbine technology. High temperature development will lead to the increased firing temperatures needed to achieve ATS Program efficiency goals. Ceramic component development/demonstration will expand the current DOE/CE program to demonstrate industrial-scale turbines with ceramic components. Technology base will support the overall program by conducting research and development (R&D) on generic technology issues. Coal application studies will adapt technology developed in the ATS program to coal-fired systems being developed in other DOE programs.

  20. Flow interaction of diffuser augmented wind turbines

    Science.gov (United States)

    Göltenbott, U.; Ohya, Y.; Yoshida, S.; Jamieson, P.

    2016-09-01

    Up-scaling of wind turbines has been a major trend in order to reduce the cost of energy generation from the wind. Recent studies however show that for a given technology, the cost always rises with upscaling, notably due to the increased mass of the system. To reach capacities beyond 10 MW, multi-rotor systems (MRS) have promising advantages. On the other hand, diffuser augmented wind turbines (DAWTs) can significantly increase the performance of the rotor. Up to now, diffuser augmentation has only been applied to single small wind turbines. In the present research, DAWTs are used in a multi-rotor system. In wind tunnel experiments, the aerodynamics of two and three DAWTs, spaced in close vicinity in the same plane normal to a uniform flow, have been analysed. Power increases of up to 5% and 9% for the two and three rotor configurations are respectively achieved in comparison to a stand-alone turbine. The physical dynamics of the flows are analysed on the basis of the results obtained with a stand-alone turbine.

  1. Advanced multistage turbine blade aerodynamics, performance, cooling, and heat transfer

    Energy Technology Data Exchange (ETDEWEB)

    Fleeter, S.; Lawless, P.B. [Purdue Univ., West Lafayette, IN (United States)

    1995-10-01

    The gas turbine has the potential for power production at the highest possible efficiency. The challenge is to ensure that gas turbines operate at the optimum efficiency so as to use the least fuel and produce minimum emissions. A key component to meeting this challenge is the turbine. Turbine performance, both aerodynamics and heat transfer, is one of the barrier advanced gas turbine development technologies. This is a result of the complex, highly three-dimensional and unsteady flow phenomena in the turbine. Improved turbine aerodynamic performance has been achieved with three-dimensional highly-loaded airfoil designs, accomplished utilizing Euler or Navier-Stokes Computational Fluid Dynamics (CFD) codes. These design codes consider steady flow through isolated blade rows. Thus they do not account for unsteady flow effects. However, unsteady flow effects have a significant impact on performance. Also, CFD codes predict the complete flow field. The experimental verification of these codes has traditionally been accomplished with point data - not corresponding plane field measurements. Thus, although advanced CFD predictions of the highly complex and three-dimensional turbine flow fields are available, corresponding data are not. To improve the design capability for high temperature turbines, a detailed understanding of the highly unsteady and three-dimensional flow through multi-stage turbines is necessary. Thus, unique data are required which quantify the unsteady three-dimensional flow through multi-stage turbine blade rows, including the effect of the film coolant flow. This requires experiments in appropriate research facilities in which complete flow field data, not only point measurements, are obtained and analyzed. Also, as design CFD codes do not account for unsteady flow effects, the next logical challenge and the current thrust in CFD code development is multiple-stage analyses that account for the interactions between neighboring blade rows.

  2. Clinical pharmacology of CAR-T cells: Linking cellular pharmacodynamics to pharmacokinetics and antitumor effects.

    Science.gov (United States)

    Norelli, M; Casucci, M; Bonini, C; Bondanza, A

    2016-01-01

    Adoptive cell transfer of T cells genetically modified with tumor-reactive chimeric antigen receptors (CARs) is a rapidly emerging field in oncology, which in preliminary clinical trials has already shown striking antitumor efficacy. Despite these premises, there are still a number of open issues related to CAR-T cells, spanning from their exact mechanism of action (pharmacodynamics), to the factors associated with their in vivo persistence (pharmacokinetics), and, finally, to the relative contribution of each of the two in determining the antitumor effects and accompanying toxicities. In light of the unprecedented curative potential of CAR-T cells and of their predicted wide availability in the next few years, in this review we will summarize the current knowledge on the clinical pharmacology aspects of what is anticipated to be a brand new class of biopharmaceuticals to join the therapeutic armamentarium of cancer doctors. Copyright © 2015. Published by Elsevier B.V.

  3. Investigation on Superior Performance by Fractional Controller for Cart-Servo Laboratory Set-Up

    Directory of Open Access Journals (Sweden)

    Ameya Anil Kesarkar

    2014-01-01

    Full Text Available In this paper, an investigation is made on the superiority of fractional PID controller (PI^alpha D^beta over conventional PID for the cart-servo laboratory set-up. The designed controllers are optimum in the sense of Integral Absolute Error (IAE and Integral Square Error (ISE. The paper contributes in three aspects: 1 Acquiring nonlinear mathematical model for the cart-servo laboratory set-up, 2 Designing fractional and integer order PID for minimizing IAE, ISE, 3 Analyzing the performance of designed controllers for simulated plant model as well as real plant. The results show a significantly superior performance by PI^alpha D^beta as compared to the conventional PID controller.

  4. Penser et activer les relations entre cartes et récits

    Directory of Open Access Journals (Sweden)

    SÉBASTIEN CAQUARD

    2015-03-01

    Full Text Available De prime abord, récit et carte semblent en opposition directe. Le récit offre un point de vue partiel et personnel, souvent chronologique et intimement associé à une trame narrative structurée autour d’évènements vécus, imaginés ou remémorés par un sujet concret engagé dans un cheminement. La carte s’ingénie à présenter de manière synthétique et abstraite des données quantifiables à partir d’un point distant, figé dans le temps, dépersonnalisé et aérien.

  5. Large wind turbine development in Europe

    Energy Technology Data Exchange (ETDEWEB)

    Zervos, A. [Center for Renewable Energy Sources, Attikis (Greece)

    1996-12-31

    During the last few years we have witnessed in Europe the development of a new generation of wind turbines ranging from 1000-1500 kW size. They are presently being tested and they are scheduled to reach the market in late 1996 early 1997. The European Commission has played a key role by funding the research leading to the development of these turbines. The most visible initiative at present is the WEGA program - the development, together with Europe`s leading wind industry players of a new generation of turbines in the MW range. By the year 1997 different European manufacturers will have introduced almost a dozen new MW machine types to the international market, half of them rated at 1.5 MW. 3 refs., 3 tabs.

  6. Power electronics converters for wind turbine systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Liserre, Marco; Ma, Ke

    2011-01-01

    The steady growth of installed wind power which reached 200 GW capacity in 2010, together with the up-scaling of the single wind turbine power capability - 7 MW’s has been announced by manufacturers - has pushed the research and development of power converters towards full scale power conversion,...

  7. Power Electronics Converters for Wind Turbine Systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Liserre, Marco; Ma, Ke

    2012-01-01

    The steady growth of installed wind power together with the upscaling of the single wind turbine power capability has pushed the research and development of power converters toward full-scale power conversion, lowered cost pr kW, increased power density, and also the need for higher reliability. ...

  8. Impingement jet cooling in gas turbines

    CERN Document Server

    Amano, R S

    2014-01-01

    Due to the requirement for enhanced cooling technologies on modern gas turbine engines, advanced research and development has had to take place in field of thermal engineering. Impingement jet cooling is one of the most effective in terms of cooling, manufacturability and cost. This is the first to book to focus on impingement cooling alone.

  9. Inventaire des cartes climatiques conservées à la cartothèque de l' IGN

    Directory of Open Access Journals (Sweden)

    Bernadette Joseph

    2010-12-01

    Full Text Available Cet inventaire présente la liste des cartes climatiques étrangères, conservées à la cartothèque de l' IGN. Ce fonds très riche en cartes thématiques n'est actuellement pas répertorié dans les catalogues SUDOC ou OPALE. Il n'est accessible qu'en interne sur fichiers papier.

  10. Synergistic effect of CART (cocaine- and amphetamine-regulated transcript peptide and cholecystokinin on food intake regulation in lean mice

    Directory of Open Access Journals (Sweden)

    Kiss Alexander

    2008-10-01

    Full Text Available Abstract Background CART (cocaine- and amphetamine-regulated transcript peptide and cholecystokinin (CCK are neuromodulators involved in feeding behavior. This study is based on previously found synergistic effect of leptin and CCK on food intake and our hypothesis on a co-operation of the CART peptide and CCK in food intake regulation and Fos activation in their common targets, the nucleus tractus solitarii of the brainstem (NTS, the paraventricular nucleus (PVN, and the dorsomedial nucleus (DMH of the hypothalamus. Results In fasted C57BL/6 mice, the anorexigenic effect of CART(61-102 in the doses of 0.1 or 0.5 μg/mouse was significantly enhanced by low doses of CCK-8 of 0.4 or 4 μg/kg, while 1 mg/kg dose of CCK-A receptor antagonist devazepide blocked the effect of CART(61-102 on food intake. After simultaneous administration of 0.1 μg/mouse CART(61-102 and of 4 μg/kg of CCK-8, the number of Fos-positive neurons in NTS, PVN, and DMH was significantly higher than after administration of each particular peptide. Besides, CART(61-102 and CCK-8 showed an additive effect on inhibition of the locomotor activity of mice in an open field test. Conclusion The synergistic and long-lasting effect of the CART peptide and CCK on food intake and their additive effect on Fos immunoreactivity in their common targets suggest a co-operative action of CART peptide and CCK which could be related to synergistic effect of leptin on CCK satiety.

  11. Gas turbine engine turbine blade damaging estimate in maintenance

    Directory of Open Access Journals (Sweden)

    Ель-Хожайрі Хусейн

    2004-01-01

    Full Text Available  The factors determining character and intensity of corrosive damages of gas turbine blades are analyzed in the article. The classification of detrimental impurities polluting gas turbine airflow duct and injuring blade erosion damages are given. Common features of the method of turbine blade corrosive damage estimation are shown in the article.

  12. Peptid CART (cocaine- and amphetamine- regulated transcript) v signalizaci buněk PC12

    Czech Academy of Sciences Publication Activity Database

    Nagelová, Veronika; Železná, Blanka; Maletínská, Lenka

    2014-01-01

    Roč. 108, č. 5 (2014), s. 543 ISSN 0009-2770. [Mezioborové setkání mladých biologů, biochemiků a chemiků /14./. 13.05.2014-16.05.2014, Milovy] R&D Projects: GA ČR GAP303/10/1368 Institutional support: RVO:61388963 Keywords : peptide CART * PC12 * c-Jun * SAPK/JNK Subject RIV: CE - Biochemistry

  13. VERA Pin and Fuel Assembly Depletion Benchmark Calculations by McCARD and DeCART

    Energy Technology Data Exchange (ETDEWEB)

    Park, Ho Jin; Cho, Jin Young [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    Monte Carlo (MC) codes have been developed and used to simulate a neutron transport since MC method was devised in the Manhattan project. Solving the neutron transport problem with the MC method is simple and straightforward to understand. Because there are few essential approximations for the 6- dimension phase of a neutron such as the location, energy, and direction in MC calculations, highly accurate solutions can be obtained through such calculations. In this work, the VERA pin and fuel assembly (FA) depletion benchmark calculations are performed to examine the depletion capability of the newly generated DeCART multi-group cross section library. To obtain the reference solutions, MC depletion calculations are conducted using McCARD. Moreover, to scrutinize the effect by stochastic uncertainty propagation, uncertainty propagation analyses are performed using a sensitivity and uncertainty (S/U) analysis method and stochastic sampling (S.S) method. It is still expensive and challenging to perform a depletion analysis by a MC code. Nevertheless, many studies and works for a MC depletion analysis have been conducted to utilize the benefits of the MC method. In this study, McCARD MC and DeCART MOC transport calculations are performed for the VERA pin and FA depletion benchmarks. The DeCART depletion calculations are conducted to examine the depletion capability of the newly generated multi-group cross section library. The DeCART depletion calculations give excellent agreement with the McCARD reference one. From the McCARD results, it is observed that the MC depletion results depend on how to split the burnup interval. First, only to quantify the effect of the stochastic uncertainty propagation at 40 DTS, the uncertainty propagation analyses are performed using the S/U and S.S. method.

  14. Registro de los cartógrafos medievales activos en el puerto de Mallorca

    Directory of Open Access Journals (Sweden)

    Llompart, Gabriel

    1997-12-01

    Full Text Available In medieval times, with the opening of the Atlantic trading routes at the beginning of the 14th century, the port of the Ciutat de Mallorques became important as the base of a gathering of both cartographers and copiers of maps. Today these maps are dispersed in museums throughout the world. Until the present day, these early map makers were known only through their works. Presented here is the first register of the "maestros" of navigational charts who worked in the "port of Mallorca". The documentation is taken from local notarial and administrative sources, all of which help the better clarification of their names, birthplaces, their Sitz im Leben and their methods of production, which were later surpassed and improved by the advent of the modern printing press.[fr] Le port de Ciutat de Mallorques fût très important pour l'histoire de la cartographie médiévale, parce-qu'un certain nombre de dessinateurs et copistes de cartes s'établirent là au commencement du XIV siècle, en raison de l'ouverture de la route atlantique. Maintenant, ces cartes se trouvent dispersées en diferents musées par tout le monde. Les auteurs de ces cartes étaient connus et datés jusqu'aujourd'hui à travers ses ouvrages. Dans cet article nous est donné un premier registre des maîtres de cartes de naviguer que travaillèrent au port de Majorque, provenant de sources locales, notariales et administratives, que nous permettent d'eclircir leurs noms, leur date de naissance leur Sitz im Leben et leurs méthodes de travail, peu après débordés et dépassés par la presse moderne.

  15. CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia.

    Science.gov (United States)

    Wang, Jinghua; Chen, Siyu; Xiao, Wei; Li, Wende; Wang, Liang; Yang, Shuo; Wang, Weida; Xu, Liping; Liao, Shuangye; Liu, Wenjian; Wang, Yang; Liu, Nawei; Zhang, Jianeng; Xia, Xiaojun; Kang, Tiebang; Chen, Gong; Cai, Xiuyu; Yang, Han; Zhang, Xing; Lu, Yue; Zhou, Penghui

    2018-01-10

    Acute myeloid leukemia (AML) is one of the most common types of adult acute leukemia. Standard chemotherapies can induce complete remission in selected patients; however, a majority of patients eventually relapse and succumb to the disease. Thus, the development of novel therapeutics for AML is urgently needed. Human C-type lectin-like molecule-1 (CLL-1) is a type II transmembrane glycoprotein, and its expression is restricted to myeloid cells and the majority of AML blasts. Moreover, CLL-1 is expressed in leukemia stem cells (LSCs), but absent in hematopoietic stem cells (HSCs), which may provide a potential therapeutic target for AML treatment. We tested the expression of CLL-1 antigen on peripheral blood cells and bone marrow cells in healthy donor and AML patients. Then, we developed a chimeric antigen receptor (CAR) containing a CLL1-specific single-chain variable fragment, in combination with CD28, 4-1BB costimulatory domains, and CD3-ζ signaling domain. We further investigate the function of CLL-1 CAR-T cells. The CLL-1 CAR-T cells specifically lysed CLL-1 + cell lines as well as primary AML patient samples in vitro. Strong anti-leukemic activity was observed in vivo by using a xenograft model of disseminated AML. Importantly, CLL-1 + myeloid progenitor cells and mature myeloid cells were specifically eliminated by CLL-1 CAR-T cells, while normal HSCs were not targeted due to the lack of CLL-1 expression. CLL-1 CAR-T represents a promising immunotherapy for the treatment of AML.

  16. The vending and à la carte policy intervention in Maine public high schools.

    Science.gov (United States)

    Davee, Anne-Marie; Blum, Janet E Whatley; Devore, Rachel L; Beaudoin, Christina M; Kaley, Lori A; Leiter, Janet L; Wigand, Debra A

    2005-11-01

    A healthy school nutrition environment may be important for decreasing childhood overweight. This article describes a project to make healthier snacks and beverages available in vending machines and à la carte programs in Maine public high schools. Seven public high schools in Maine volunteered to participate in this project. Four schools made changes to the nutrition environment, and three schools that served as controls did not. The nutrition guidelines were to offer only low-fat (not more than 30% of total calories from fat) and low-sugar (not more than 35% by weight of sugar) items in vending machines and à la carte programs. Strategies to implement the project included early communications with school officials, monetary stipends for participation, identification of a school liaison, and a committee at each school to promote the healthy changes. Baseline nutrient content and sales of all competitive foods and beverages were assessed to develop the guidelines for changes in the four schools. Student volunteers at all seven schools were measured for height, weight, diet quality, and physical activity level to assess the impact of the change to the nutrition environment. Baseline measures were taken in the spring semester of 2004. Nutrition changes were made to the à la carte programs and vending machines in the four intervention schools at the start of the fall semester of 2004. Follow-up nutrition assessment and student data collection occurred in the spring semester of 2005. Healthy changes in vending machines were more easily achieved than those made in the à la carte programs. Technical assistance and ongoing support were essential for successful implementation of this intervention. It is possible to improve the nutrition environment of Maine public high schools. Stakeholder support is essential to sustain healthy changes.

  17. Penyusunan Dan Penyelenggaran A La Carte Menu Pada Hotel Sinabung Dan Resort

    OpenAIRE

    Nasution, Rahmawaty

    2011-01-01

    Dalam operasional hotel, hotel memiliki beberapa departemen yang mempunyai peranan yang sangat penting dalam penjualan jasa dan pelayanan, dan salah satunya adalah departemen Food & Beverage. Food & Beverage mempunyai peran yang sangat besar dalam sebuah hotel, karena pendapatan sebuah hotel yang terbesar ada pada Food & Beverage terutama pada restoran. Adapun salah satu nama jenis restoran yang ada di Hotel Sinabung. Hotel Sinabung menyediakan jenis menu antara lain A La Carte Menu. M...

  18. Shopper marketing nutrition interventions: Social norms on grocery carts increase produce spending without increasing shopper budgets☆

    Science.gov (United States)

    Payne, Collin R.; Niculescu, Mihai; Just, David R.; Kelly, Michael P.

    2015-01-01

    Objectives We assessed the efficacy of an easy-to-implement shopper marketing nutrition intervention in a pilot and two additional studies to increase produce demand without decreasing store profitability or increasing shopper budgets. Methods We created grocery cart placards that detailed the number of produce items purchased (i.e., descriptive norm) at particular stores (i.e., provincial norm). The effect of these placards on produce spending was assessed across 971,706 individual person grocery store transactions aggregated by day. The pilot study designated a baseline period (in both control and intervention store) followed by installation of grocery cart placards (in the intervention store) for two weeks. The pilot study was conducted in Texas in 2012. In two additional stores, we designated baseline periods followed by 28 days of the same grocery cart placard intervention as in the pilot. Additional interventions were conducted in New Mexico in 2013. Results The pilot study resulted in a significant difference between average produce spending per day per person across treatment periods (i.e., intervention versus same time period in control) (16%) and the difference between average produce spending per day per person across stores in the control periods (4%); Furthermore, the same intervention in two additional stores resulted in significant produce spending increases of 12.4% and 7.5% per day per person respectively. In all stores, total spending did not change. Conclusions Descriptive and provincial social norm messages (i.e., on grocery cart placards) may be an overlooked tool to increase produce demand without decreasing store profitability and increasing shopper budgets. PMID:26844084

  19. Le CO.C.A.O: le commentaire de carte assisté par ordinateur

    Directory of Open Access Journals (Sweden)

    Joël CHARRE

    1991-12-01

    Full Text Available Le contenu d’une carte topographique peut être enregistré informatiquement sous forme d’un Système d’Information Géographique (SIG raster. En changeant de support, l’information change de nature: de fixe, elle devient manipulable, adaptable, vivante. L’analyse spatiale peut alors reposer sur des mesures de superficies, des fréquences de co-occurrences, des proximités...

  20. Power curve of the AWEC-60 wind turbine

    International Nuclear Information System (INIS)

    Avia, F.

    1992-01-01

    The experimental wind turbine AWEC-60 was developed to evaluate the possibilities of the Large Wind turbines, from the technical and economical point of view. The project was developed by a spanish-german group, integrated by Union Fenosa, Asinel, M.A.N. Neue Technologie and the Instituto de Energias Renovables from CIEMAT, starting the operation during the year 1990. In this paper, the obtention of the wind turbine's power curve is presented, which has been obtained in agreement with the 'Recommended Practices for Wind Turbine Testing and Evaluation' from the Executive Committee for the Research and Development on Wind Energy, of the International Energy Agency (AIE). Using the functioning data of the wind turbine corresponding to the first quarter of the year 1991, the power curves have been obtained, and the results have been compared with the curves measured in other similar large windturbines. (author)

  1. Optimization design of blade shapes for wind turbines

    DEFF Research Database (Denmark)

    Chen, Jin; Wang, Xudong; Shen, Wen Zhong

    2010-01-01

    For the optimization design of wind turbines, the new normal and tangential induced factors of wind turbines are given considering the tip loss of the normal and tangential forces based on the blade element momentum theory and traditional aerodynamic model. The cost model of the wind turbines...... and the optimization design model are developed. In the optimization model, the objective is the minimum cost of energy and the design variables are the chord length, twist angle and the relative thickness. Finally, the optimization is carried out for a 2 MW blade by using this optimization design model....... The performance of blades is validated through the comparison and analysis of the results. The reduced cost shows that the optimization model is good enough for the design of wind turbines. The results give a proof for the design and research on the blades of large scale wind turbines and also establish...

  2. Numerical Analysis of Impulse Turbine for Isolated Pilot OWC System

    Directory of Open Access Journals (Sweden)

    Zhen Liu

    2013-01-01

    Full Text Available Oscillating water column (OWC is the most widely used wave energy converting technology in the world. The impulse turbine is recently been employed as the radial turbine in OWC facilities to convert bidirectional mechanical air power into electricity power. 3D numerical model for the impulse turbine is established in this paper to investigate its operating performance of the designed impulse turbine for the pilot OWC system which is under the construction on Jeju Island, Republic of Korea. The proper mesh style, turbulence model, and numerical solutions are employed to study the velocity and air pressure distribution especially around the rotor blade. The operating coefficients obtained from the numerical simulation are compared with corresponding experimental data, which demonstrates that the 3D numerical model proposed here can be applied to the research of impulse turbines for OWC system. Effects of tip clearances on flow field distribution characteristics and operating performances are also studied.

  3. Vertical axis wind turbines: a survey and bibliography

    Energy Technology Data Exchange (ETDEWEB)

    Abramovich, H

    1987-01-01

    The stimulus for the development of modern, big wind turbines has been the world-wide oil crisis during the seventies. Although the horizontal axis wind turbines (HAWT) was the most popular type of wind turbine the Darrieus vertical axis wind turbine (VAWT) has been recognized as a machine with competitive economic potential. The state of the art of the VAWT is reviewed. The wind turbine carrying the name of Darrieus was first proposed by the French inventor in 1925. His original patent covered a range of vertical-axis configurations but the term 'Darrieus' is now generally associated with the curved-blade geometry. In 1966 two researchers at the Canadian NRC again raised the idea of both the straight and curved-blade versions of the Darrieus VAWT.

  4. P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain.

    Science.gov (United States)

    Iioka, Takashi; Furukawa, Keizo; Yamaguchi, Akira; Shindo, Hiroyuki; Yamashita, Shunichi; Tsukazaki, Tomoo

    2003-08-01

    The paired-like homeoprotein, Cart1, is involved in skeletal development. We describe here that the general coactivator p300/CBP controls the transcription activity of Cart1 through acetylation of a lysine residue that is highly conserved in other homeoproteins. Acetylation of this residue increases the interaction between p300/CBP and Cart1 and enhances its transcriptional activation. Cart1 encodes a paired-like homeoprotein expressed selectively in chondrocyte lineage during embryonic development. Although its target gene remains unknown, gene disruption studies have revealed that Cart1 plays an important role for craniofacial bone formation as well as limb development by cooperating with another homeoprotein, Alx4. In this report, we study the functional involvement of p300/CBP, coactivators with intrinsic histone acetyltransferase (HAT) activity, in the transcriptional control of Cart1. To study the transcription activity of Cart1, a reporter construct containing a putative Cart1 binding site was transiently transfected with the expression vectors of each protein. The interaction between p300/CBP and Cart1 was investigated by glutathione S-transferase (GST) pull-down, yeast two-hybrid, and immunoprecipitation assays. In vitro acetylation assay was performed with the recombinant p300-HAT domain and Cart1 in the presence of acetyl-CoA. p300 and CBP stimulate Cart1-dependent transcription activity, and this transactivation is inhibited by E1A and Tax, oncoproteins that suppress the activity of p300/CBP. Cart1 binds to p300 in vivo and in vitro, and this requires the homeodomain of Cart 1 and N-terminal 139 amino acids of p300. Confocal microscopy analysis shows that Cart1 recruits overexpressed and endogenous p300 to a Cart1-specific subnuclear compartment. Cart1 is acetylated in vivo and sodium butyrate and trichostatin A, histone deacetylase inhibitors, markedly enhance the transcription activity of Cart1. Deletion and mutagenesis analysis identifies the 131st

  5. Wind turbine noise diagnostics

    International Nuclear Information System (INIS)

    Richarz, W.; Richarz, H.

    2009-01-01

    This presentation proposed a self-consistent model for broad-band noise emitted from modern wind turbines. The simple source model was consistent with the physics of sound generation and considered the unique features of wind turbines. Although the acoustics of wind turbines are similar to those of conventional propellers, the dimensions of wind turbines pose unique challenges in diagnosing noise emission. The general features of the sound field were deduced. Source motion and source directivity appear to be responsible for amplitude variations. The amplitude modulation is likely to make wind-turbine noise more audible, and may be partly responsible for annoyance that has been reported in the literature. Acoustic array data suggests that broad-band noise is emitted predominantly during the downward sweep of each rotor blade. Source motion and source directivity account for the observed pattern. Rotor-tower interaction effects are of lesser importance. Predicted amplitude modulation ranges from 1 dB to 6dB. 2 refs., 9 figs.

  6. Floating wind turbine system

    Science.gov (United States)

    Viterna, Larry A. (Inventor)

    2009-01-01

    A floating wind turbine system with a tower structure that includes at least one stability arm extending therefrom and that is anchored to the sea floor with a rotatable position retention device that facilitates deep water installations. Variable buoyancy for the wind turbine system is provided by buoyancy chambers that are integral to the tower itself as well as the stability arm. Pumps are included for adjusting the buoyancy as an aid in system transport, installation, repair and removal. The wind turbine rotor is located downwind of the tower structure to allow the wind turbine to follow the wind direction without an active yaw drive system. The support tower and stability arm structure is designed to balance tension in the tether with buoyancy, gravity and wind forces in such a way that the top of the support tower leans downwind, providing a large clearance between the support tower and the rotor blade tips. This large clearance facilitates the use of articulated rotor hubs to reduced damaging structural dynamic loads. Major components of the turbine can be assembled at the shore and transported to an offshore installation site.

  7. High Combustion Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — At NETL's High-Pressure Combustion Research Facility in Morgantown, WV, researchers can investigate new high-pressure, high-temperature hydrogen turbine combustion...

  8. Anthelmintic Resistance of Strongyle Nematodes to Ivermectin and Fenbendazole on Cart Horses in Gondar, Northwest Ethiopia

    Directory of Open Access Journals (Sweden)

    Zewdu Seyoum

    2017-01-01

    Full Text Available A study was conducted from November 2015 to April 2016 to determine fenbendazole and ivermectin resistance status of intestinal nematodes of cart horses in Gondar, Northwest Ethiopia. Forty-five strongyle infected animals were used for this study. The animals were randomly allocated into three groups (15 horses per group. Group I was treated with fenbendazole and Group II with ivermectin and Group III was left untreated. Faecal samples were collected from each cart horse before and after treatment. Accordingly, the reduction in the mean fecal egg count at fourteen days of treatment for ivermectin and fenbendazole was 97.25% and 79.4%, respectively. It was significantly different in net egg count between treatment and control groups after treatment. From the study, resistance level was determined for fenbendazole and suspected for ivermectin. In addition, a questionnaire survey was also conducted on 90 selected cart owners to assess their perception on anthelmintics. In the survey, the most available drugs in the study area used by the owners were fenbendazole and ivermectin. Most respondents have no knowledge about drug management techniques. Hence, animal health extension services to create awareness regarding anthelmintic management that plays a key role in reducing the anthelmintic resistance parasites.

  9. Anthelmintic Resistance of Strongyle Nematodes to Ivermectin and Fenbendazole on Cart Horses in Gondar, Northwest Ethiopia.

    Science.gov (United States)

    Seyoum, Zewdu; Zewdu, Alemu; Dagnachew, Shimelis; Bogale, Basazinew

    2017-01-01

    A study was conducted from November 2015 to April 2016 to determine fenbendazole and ivermectin resistance status of intestinal nematodes of cart horses in Gondar, Northwest Ethiopia. Forty-five strongyle infected animals were used for this study. The animals were randomly allocated into three groups (15 horses per group). Group I was treated with fenbendazole and Group II with ivermectin and Group III was left untreated. Faecal samples were collected from each cart horse before and after treatment. Accordingly, the reduction in the mean fecal egg count at fourteen days of treatment for ivermectin and fenbendazole was 97.25% and 79.4%, respectively. It was significantly different in net egg count between treatment and control groups after treatment. From the study, resistance level was determined for fenbendazole and suspected for ivermectin. In addition, a questionnaire survey was also conducted on 90 selected cart owners to assess their perception on anthelmintics. In the survey, the most available drugs in the study area used by the owners were fenbendazole and ivermectin. Most respondents have no knowledge about drug management techniques. Hence, animal health extension services to create awareness regarding anthelmintic management that plays a key role in reducing the anthelmintic resistance parasites.

  10. An application of CART algorithm in genetics: IGFs and cGH polymorphisms in Japanese quail

    Science.gov (United States)

    Kaplan, Selçuk

    2017-04-01

    The avian insulin-like growth factor-1 (IGFs) and avian growth hormone (cGH) genes are the most important genes that can affect bird performance traits because of its important function in growth and metabolism. Understanding the molecular genetic basis of variation in growth-related traits is of importance for continued improvement and increased rates of genetic gain. The objective of the present study was to identify polymorphisms of cGH and IGFs genes in Japanese quail using conventional least square method (LSM) and CART algorithm. Therefore, this study was aimed to demonstrate at determining the polymorphisms of two genes related growth characteristics via CART algorithm. A simulated data set was generated to analyze by adhering the results of some poultry genetic studies which it includes live weights at 5 weeks of age, 3 alleles and 6 genotypes of cGH and 2 alleles and 3 genotypes of IGFs. As a result, it has been determined that the CART algorithm has some advantages as for that LSM.

  11. Automated Cart with VIS/NIR Hyperspectral Reflectance and Fluorescence Imaging Capabilities

    Directory of Open Access Journals (Sweden)

    Alan M. Lefcourt

    2016-12-01

    Full Text Available A system to take high-resolution Visible/Near Infra-Red (VIS/NIR hyperspectral reflectance and fluorescence images in outdoor fields using ambient lighting or a pulsed laser (355 nm, respectively, for illumination purposes was designed, built, and tested. Components of the system include a semi-autonomous cart, a gated-intensified camera, a spectral adapter, a frequency-triple Nd:YAG (Neodymium-doped Yttrium Aluminium Garnet laser, and optics to convert the Gaussian laser beam into a line-illumination source. The front wheels of the cart are independently powered by stepper motors that support stepping or continuous motion. When stepping, a spreadsheet is used to program parameters of image sets to be acquired at each step. For example, the spreadsheet can be used to set delays before the start of image acquisitions, acquisition times, and laser attenuation. One possible use of this functionality would be to establish acquisition parameters to facilitate the measurement of fluorescence decay-curve characteristics. The laser and camera are mounted on an aluminum plate that allows the optics to be calibrated in a laboratory setting and then moved to the cart. The system was validated by acquiring images of fluorescence responses of spinach leaves and dairy manure.

  12. New Strategies for the Treatment of Solid Tumors with CAR-T Cells.

    Science.gov (United States)

    Zhang, Hao; Ye, Zhen-Long; Yuan, Zhen-Gang; Luo, Zheng-Qiang; Jin, Hua-Jun; Qian, Qi-Jun

    2016-01-01

    Recent years, we have witnessed significant progresses in both basic and clinical studies regarding novel therapeutic strategies with genetically engineered T cells. Modification with chimeric antigen receptors (CARs) endows T cells with tumor specific cytotoxicity and thus induce anti-tumor immunity against malignancies. However, targeting solid tumors is more challenging than targeting B-cell malignancies with CAR-T cells because of the histopathological structure features, specific antigens shortage and strong immunosuppressive environment of solid tumors. Meanwhile, the on-target/off-tumor toxicity caused by relative expression of target on normal tissues is another issue that should be reckoned. Optimization of the design of CAR vectors, exploration of new targets, addition of safe switches and combination with other treatments bring new vitality to the CAR-T cell based immunotherapy against solid tumors. In this review, we focus on the major obstacles limiting the application of CAR-T cell therapy toward solid tumors and summarize the measures to refine this new cancer therapeutic modality.

  13. A Novel Biped Pattern Generator Based on Extended ZMP and Extended Cart-Table Model

    Directory of Open Access Journals (Sweden)

    Guangbin Sun

    2015-07-01

    Full Text Available This paper focuses on planning patterns for biped walking on complex terrains. Two problems are solved: ZMP (zero moment point cannot be used on uneven terrain, and the conventional cart-table model does not allow vertical CM (centre of mass motion. For the ZMP definition problem, we propose the extended ZMP (EZMP concept as an extension of ZMP to uneven terrains. It can be used to judge dynamic balance on universal terrains. We achieve a deeper insight into the connection and difference between ZMP and EZMP by adding different constraints. For the model problem, we extend the cart-table model by using a dynamic constraint instead of constant height constraint, which results in a mathematically symmetric set of three equations. In this way, the vertical motion is enabled and the resultant equations are still linear. Based on the extended ZMP concept and extended cart-table model, a biped pattern generator using triple preview controllers is constructed and implemented simultaneously to three dimensions. Using the proposed pattern generator, the Atlas robot is simulated. The simulation results show the robot can walk stably on rather complex terrains by accurately tracking extended ZMP.

  14. Developmental status of preschool children receiving cART: a descriptive cohort study.

    Science.gov (United States)

    Potterton, J; Hilburn, N; Strehlau, R

    2016-05-01

    HIV is known to cause neurodevelopmental problems in infants and young children. The impact of HIV on the development of preschool-age children has been less well described. The study was conducted at an urban paediatric HIV clinic in Johannesburg, South Africa. A sample of convenience was used. Sixty-eight medically stable children between the ages of 3 and 5 years were assessed with the Griffiths Scales of Mental Development. Children were excluded from the study if they had severe HIV encephalopathy, which made it impossible for them to participate in the items on the Griffiths Scales of Mental Development. The children had started combination antiretroviral treatment (cART) at a mean age of 8.1 months. The majority of the children were virologically suppressed and did not present with wasting or stunting. Severe overall developmental delay (z-scores perception were the most severely affected. Personal-social development was the least affected with only 13.4% of the children demonstrating severe delay. Despite having early access to cART, children infected with HIV are still at risk for severe developmental delay across a number of facets. Very early initiation of cART may help alleviate this problem. All preschool children infected with HIV should have routine developmental screening. © 2016 John Wiley & Sons Ltd.

  15. Flashback mechanisms in lean premixed gas turbine combustion

    CERN Document Server

    Benim, Ali Cemal

    2014-01-01

    Blending fuels with hydrogen offers the potential to reduce NOx and CO2 emissions in gas turbines, but doing so introduces potential new problems such as flashback.  Flashback can lead to thermal overload and destruction of hardware in the turbine engine, with potentially expensive consequences. The little research on flashback that is available is fragmented. Flashback Mechanisms in Lean Premixed Gas Turbine Combustion by Ali Cemal Benim will address not only the overall issue of the flashback phenomenon, but also the issue of fragmented and incomplete research.Presents a coherent review of f

  16. Nursing perception of the impact of medication carts on patient safety and ergonomics in a teaching health care center.

    Science.gov (United States)

    Rochais, Élise; Atkinson, Suzanne; Bussières, Jean-François

    2013-04-01

    In our Quebec (Canada) University Hospital Center, 68 medication carts have been implemented as part of a nationally funded project on drug distribution technologies. There are limited data published about the impact of medication carts in point-of-care units. Our main objective was to assess nursing staff's perception and satisfaction of medication carts on patient safety and ergonomics. Quantitative and qualitative cross-sectional study. Data were gathered from a printed questionnaire administered to nurses and an organized focus group composed of nurses and pharmacists. A total of 195 nurses completed the questionnaire. Eighty percent of the nurses agreed that medication carts made health care staff's work easier and 64% agreed that it helped to reduce medication incidents/accidents. Only 27% and 43% agreed that carts' location reduces the risk of patients' interruptions and colleagues' interruptions, respectively. A total of 17 suggestions were extracted from the focus group (n = 7 nurses; n = 3 pharmacist) and will be implemented in the next year. This descriptive study confirms the positive perception and satisfaction of nurses exposed to medication carts. However, interruptions are a major concern and source of dissatisfaction. The focus group has revealed many issues which will be improved.

  17. Allogeneic CD19-CAR-T cell infusion after allogeneic hematopoietic stem cell transplantation in B cell malignancies.

    Science.gov (United States)

    Liu, Jun; Zhong, Jiang F; Zhang, Xi; Zhang, Cheng

    2017-01-31

    Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the cornerstone in treatment of hematological malignancies. However, relapse of the hematological disease after allo-HSCT remains a challenge and is associated with poor long-term survival. Chimeric antigen receptor redirected T cells (CAR-T cells) can lead to disease remission in patients with relapsed/refractory hematological malignancies. However, the therapeutic window for infusion of CAR-T cells post allo-HSCT and its efficacy are debatable. In this review, we first discuss the use of CAR-T cells for relapsed cases after allo-HSCT. We then review the toxicities and the occurrence of graft-versus-host disease in relapsed patients who received CAR-T cells post allo-HSCT. Finally, we review clinical trial registrations and the therapeutic time window for infusion of CAR-T cells post allo-HSCT. The treatment of allogeneic CAR-T cells is beneficial for patients with relapsed B cell malignancies after allo-HSCT with low toxicities and complications. However, multicenter clinical trials with larger sample sizes should be performed to select the optimal therapeutic window and confirm its efficacy.

  18. Full scale testing for investigation of wind turbine seismic response

    Energy Technology Data Exchange (ETDEWEB)

    Prowell, I.; Veletzos, M.; Elgamal, A. [California Univ., San Diego, CA (United States). Dept. of Structural Engineering

    2008-07-01

    In 2007, much of the growth in wind energy development was concentrated in North America and Asia, two regions which periodically experience strong earthquakes that may impact the final turbine design. As such, rational prediction of seismic hazards must be considered in order to maintain and enhance the ability of wind power to compete economically with other energy sources. In response to this challenge, researchers at the University of California, San Diego (UCSD) have experimentally investigated wind turbines to gain an understanding of expected earthquake forces. This paper described the experimental setup for a full scale shake table test of a 65 kW wind turbine. The turbine was excited perpendicular to the axis of the rotor with a seismic base shaking record scaled to various levels. The data was analyzed using simple but effective procedures to provide insight into the observed structural damping of the wind turbine. The experimental investigation showed that full scale seismic testing of wind turbines is possible and can provide valuable insight into dynamic behaviour of wind turbines. The results can be used to develop a more accurate picture of how wind turbines are impacted by earthquakes. The data regarding the low observed super-structure damping provides a basis for calibration and further development of verified design procedures. 20 refs., 3 tabs.

  19. Preliminary study of Low-Cost Micro Gas Turbine

    Science.gov (United States)

    Fikri, M.; Ridzuan, M.; Salleh, Hamidon

    2016-11-01

    The electricity consumption nowadays has increased due to the increasing development of portable electronic devices. The development of low cost micro gas turbine engine, which is designed for the purposes of new electrical generation Micro turbines are a relatively new distributed generation technology being used for stationary energy generation applications. They are a type of combustion turbine that produces both heat and electricity on a relatively small scaled.. This research are focusing of developing a low-cost micro gas turbine engine based on automotive turbocharger and to evaluation the performance of the developed micro gas turbine. The test rig engine basically was constructed using a Nissan 45V3 automotive turbocharger, containing compressor and turbine assemblies on a common shaft. The operating performance of developed micro gas turbine was analyzed experimentally with the increment of 5000 RPM on the compressor speed. The speed of the compressor was limited at 70000 RPM and only 1000 degree Celsius at maximum were allowed to operate the system in order to avoid any failure on the turbocharger bearing and the other components. Performance parameters such as inlet temperature, compressor temperature, exhaust gas temperature, and fuel and air flow rates were measured. The data was collected electronically by 74972A data acquisition and evaluated manually by calculation. From the independent test shows the result of the system, The speed of the LP turbine can be reached up to 35000 RPM and produced 18.5kw of mechanical power.

  20. Laboratory development of wind turbine simulator using variable ...

    African Journals Online (AJOL)

    user

    1*Department of Electronics Engineering, Prof. ... In this paper variable speed induction motor drive using scalar control is interfaced in wind energy conversion ... the wind turbine simulator is used as a necessary tool in research laboratories.

  1. Large Wind Turbine Design Characteristics and R and D Requirements

    Science.gov (United States)

    Lieblein, S. (Editor)

    1979-01-01

    Detailed technical presentations on large wind turbine research and development activities sponsored by public and private organizations are presented. Both horizontal and vertical axis machines are considered with emphasis on their structural design.

  2. Urban small wind turbine applications for reducing GHC emissions

    International Nuclear Information System (INIS)

    Tullis, S.

    2009-01-01

    'Full text:' There are advantages to power generation at or near the points of consumption and this is still true for low carbon sustainable power sources, including wind. Consequently, there is interest in wind power generation in cities and suburbs. The potential now exists for realistic power small-scale generation in building mounted turbines. This presentation provides the benefits and obstacles to their use, as well as details of such turbines and the design and operations requirements for them. The main issues associated with locating turbines in cities and suburbs are: the highly turbulent, unsteady wind in the urban/suburban environment produces lower power outputs; vibration is a large concern on mounting turbines on buildings, and safety (turbine failure or even just ice shedding) with pedestrians below. Past and current thinking has just been straightforward in that it is not worth it, and the previous attempts at simply mounting small-scale turbines on rooftops has done more harm than good to the reputation of the small wind, and wind in general, industries. Recently there has been a reconsideration of urban small wind led by reputable companies such as Quiet Revolution (UK), Turby (NL) and Cleanfield (Canada) combined with academic research. A common feature of all of these companies is the use of vertical axis turbines (VAWTs) to help deal with the highly turbulent, unsteady urban winds. Large-scale VAWTs enjoyed a brief flurry of interest in the 1970s and 80s with large amounts of research done at Sandia and NRC in Canada. Vibration and fatigue in the large-scale turbines were among the issues that led to their decline. These, particularly vibration, remain issues for small-scale turbines, but there are some mitigating strategies available. These are now leading to the development of reputable, practical and reliable turbines that can become part of the urban/suburban environment. (author)

  3. Wind Turbine With Concentric Ducts

    Science.gov (United States)

    Muhonen, A. J.

    1983-01-01

    Wind Turbine device is relatively compact and efficient. Converging inner and outer ducts increase pressure difference across blades of wind turbine. Turbine shaft drives alternator housed inside exit cone. Suitable for installation on such existing structures as water towers, barns, houses, and commercial buildings.

  4. Structure-activity relationship of CART peptide fragments

    Czech Academy of Sciences Publication Activity Database

    Maletínská, Lenka; Maixnerová, Jana; Hlaváček, Jan; Blokešová, Darja; Elbert, Tomáš; Šanda, Miloslav; Slaninová, Jiřina; Železná, Blanka

    2007-01-01

    Roč. 88, č. 4 (2007), s. 565 ISSN 0006-3525. [American Peptide Society Symposium /20./. 26.06.2007-30.06.2007, Montreal] Institutional research plan: CEZ:AV0Z40550506 Keywords : cocaine and amphetamine regulated transcript peptide * structure * activity Subject RIV: CE - Biochemistry

  5. Wind turbine spoiler

    Science.gov (United States)

    Sullivan, W.N.

    An aerodynamic spoiler system for a vertical axis wind turbine includes spoilers on the blades initially stored near the rotor axis to minimize drag. A solenoid latch adjacent the central support tower releases the spoilers and centrifugal force causes the spoilers to move up the turbine blades away from the rotor axis, thereby producing a braking effect and actual slowing of the associated wind turbine, if desired. The spoiler system can also be used as an infinitely variable power control by regulated movement of the spoilers on the blades over the range between the undeployed and fully deployed positions. This is done by the use of a suitable powered reel and cable located at the rotor tower to move the spoilers.

  6. Steam turbine installations

    International Nuclear Information System (INIS)

    Bainbridge, A.

    1976-01-01

    The object of the arrangement described is to enable raising steam for driving steam turbines in a way suited to operating with liquid metals, such as Na, as heat transfer medium. A preheated water feed, in heat transfer relationship with the liquid metals, is passed through evaporator and superheater stages, and the superheated steam is supplied to the highest pressure stage of the steam turbine arrangement. Steam extracted intermediate the evaporator and superheater stages is employed to provide reheat for the lower pressure stage of the steam turbine. Only a major portion of the preheated water feed may be evaporated and this portion separated and supplied to the superheater stage. The feature of 'steam to steam' reheat avoids a second liquid metal heat transfer and hence represents a simplification. It also reduces the hazard associated with possible steam-liquid metal contact. (U.K.)

  7. Hydro turbines: An introduction

    International Nuclear Information System (INIS)

    Gordon, J.L.

    1993-01-01

    The various types of hydraulic turbines currently used in hydroelectric power plants are described. The descriptions are intended for use by non-engineers who are concerned with fish passage and fish mortality at a hydro power facility. Terminology used in the hydro industry is explained. Since the extent of cavitation is one of the factors affecting mortality rates of fish passing through hydraulic turbines, an equation is introduced which measures the extent of cavitation likely to be experienced in a turbine. An example of how the cavitation index can be calculated is provided for two typical power plants. The relation between certain parameters of power plant operation and the extent of cavitation, and therefore of fish mortality, is illustrated. 2 refs., 14 figs

  8. Variable stator radial turbine

    Science.gov (United States)

    Rogo, C.; Hajek, T.; Chen, A. G.

    1984-01-01

    A radial turbine stage with a variable area nozzle was investigated. A high work capacity turbine design with a known high performance base was modified to accept a fixed vane stagger angle moveable sidewall nozzle. The nozzle area was varied by moving the forward and rearward sidewalls. Diffusing and accelerating rotor inlet ramps were evaluated in combinations with hub and shroud rotor exit rings. Performance of contoured sidewalls and the location of the sidewall split line with respect to the rotor inlet was compared to the baseline. Performance and rotor exit survey data are presented for 31 different geometries. Detail survey data at the nozzle exit are given in contour plot format for five configurations. A data base is provided for a variable geometry concept that is a viable alternative to the more common pivoted vane variable geometry radial turbine.

  9. Noise from wind turbines

    International Nuclear Information System (INIS)

    Andersen, B.; Jakobsen, J.

    1992-11-01

    Based on a previous project concerning the calculation of the amount of noise emanating from wind turbine arrays, this one examines the subject further by investigating whether there could be significant differences in the amount of noise made by individual wind turbines in an array, and whether the noise is transmitted in varying directions - so that when it is carried in the same direction as the wind blows it would appear to be louder. The aim was also to determine whether the previously used method of calculation lacked precision. It was found that differences in noise niveaux related to individual wind turbines were insignificant and that noise was not so loud when it was not borne in the direction of the wind. It was necessary to change the method of calculation as reckoning should include the influence of the terrain, wind velocity and distance. The measuring and calculation methods are exemplified and the resulting measurements are presented in detail. (AB)

  10. Aeroservoelasticity of Wind Turbines

    DEFF Research Database (Denmark)

    Kallesøe, Bjarne Skovmose

    2007-01-01

    This thesis deals with the fundamental aeroelastic interaction between structural motion, Pitch action and control for a wind turbine blade. As wind turbines become larger, the interaction between pitch action, blade motion, aerodynamic forces, and control become even more important to understand......, and furthermore linear and therefore suitable for control design. The development of the primary aeroelastic blade model is divided into four steps: 1) Nonlinear partial differential equations (PDEs) of structural blade motion are derived together with equations of pitch action and rotor speed; the individual...... to a 2D blade section model, and it can be used instead of this in many applications, giving a transparent connection to a real wind turbine blade. In this work the aeroelastic blade model is used to analyze interaction between pitch action, blade motion and wind speed variations. Furthermore the model...

  11. Wind Turbine Acoustics

    Science.gov (United States)

    Hubbard, Harvey H.; Shepherd, Kevin P.

    2009-01-01

    Wind turbine generators, ranging in size from a few kilowatts to several megawatts, are producing electricity both singly and in wind power stations that encompass hundreds of machines. Many installations are in uninhabited areas far from established residences, and therefore there are no apparent environmental impacts in terms of noise. There is, however, the potential for situations in which the radiated noise can be heard by residents of adjacent neighborhoods, particularly those neighborhoods with low ambient noise levels. A widely publicized incident of this nature occurred with the operation of the experimental Mod-1 2-MW wind turbine, which is described in detail elsewhere. Pioneering studies which were conducted at the Mod-1 site on the causes and remedies of noise from wind turbines form the foundation of much of the technology described in this chapter.

  12. Micro turbines on gas

    International Nuclear Information System (INIS)

    Kotevski, Darko

    2003-01-01

    Microturbines are small gas turbine engines that drive a generator with sizes ranging from 30-350 kW. Although similar in function to bigger gas turbines, their simple radial flow turbine and high-speed generator offer better performance, greater reliability, longer service intervals, reduced maintenance lower emission and lower noise. Microturbines can generate power continuously and very economically to reduce electricity costs or they can be operated selectively for peak shaving. These benefits are further enhanced by the economics of using the microturbine's waste heat for hot water needs or other heating applications. That is why on-site microturbine power is widely used for independent production of electricity and heat in industrial and commercial facilities, hotels, hospitals, office buildings, residential buildings etc. (Original)

  13. An overview of aerospace gas turbine technology of relevance to the development of the automotive gas turbine engine

    Science.gov (United States)

    Evans, D. G.; Miller, T. J.

    1978-01-01

    The NASA-Lewis Research Center (LeRC) has conducted, and has sponsored with industry and universities, extensive research into many of the technology areas related to gas turbine propulsion systems. This aerospace-related technology has been developed at both the component and systems level, and may have significant potential for application to the automotive gas turbine engine. This paper summarizes this technology and lists the associated references. The technology areas are system steady-state and transient performance prediction techniques, compressor and turbine design and performance prediction programs and effects of geometry, combustor technology and advanced concepts, and ceramic coatings and materials technology.

  14. Steam generators, turbines, and condensers. Volume six

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    Volume six covers steam generators (How steam is generated, steam generation in a PWR, vertical U-tube steam generators, once-through steam generators, how much steam do steam generators make?), turbines (basic turbine principles, impulse turbines, reaction turbines, turbine stages, turbine arrangements, turbine steam flow, steam admission to turbines, turbine seals and supports, turbine oil system, generators), and condensers (need for condensers, basic condenser principles, condenser arrangements, heat transfer in condensers, air removal from condensers, circulating water system, heat loss to the circulating water system, factors affecting condenser performance, condenser auxiliaries)

  15. Flowfield Analysis of Savonius-type Wind Turbine blade

    Energy Technology Data Exchange (ETDEWEB)

    Noh, Tae Hyun; Chang, Se Myong [Kunsan National Univ., Kunsan (Korea, Republic of); Seo, Hyun Soo [Korea Institute of Energy Research, Daejeon (Korea, Republic of)

    2007-07-01

    In this paper, we researched flow of 8000 {approx} 24000 Reynolds number around a blade model of Savonius-type wind turbine with experimental and numerical method. For the blade shape of arc, we analyzed flowfield with streak-image flow visualization, measured wake, computed drag coefficients, and compared them for given angle of attacks. The result of research can be used to design aerodynamic performance of Savonius-type turbine rotor directly.

  16. Vertical axis wind turbines

    Science.gov (United States)

    Krivcov, Vladimir [Miass, RU; Krivospitski, Vladimir [Miass, RU; Maksimov, Vasili [Miass, RU; Halstead, Richard [Rohnert Park, CA; Grahov, Jurij [Miass, RU

    2011-03-08

    A vertical axis wind turbine is described. The wind turbine can include a top ring, a middle ring and a lower ring, wherein a plurality of vertical airfoils are disposed between the rings. For example, three vertical airfoils can be attached between the upper ring and the middle ring. In addition, three more vertical airfoils can be attached between the lower ring and the middle ring. When wind contacts the vertically arranged airfoils the rings begin to spin. By connecting the rings to a center pole which spins an alternator, electricity can be generated from wind.

  17. Vertical axis wind turbine

    International Nuclear Information System (INIS)

    Obretenov, V.; Tsalov, T.; Chakarov, T.

    2012-01-01

    In recent years, the interest in wind turbines with vertical axis noticeably increased. They have some important advantages: low cost, relatively simple structure, reliable packaging system of wind aggregate long period during which require no maintenance, low noise, independence of wind direction, etc.. The relatively low efficiency, however, makes them applicable mainly for small facilities. The work presents a methodology and software for approximately aerodynamic design of wind turbines of this type, and also analyzed the possibility of improving the efficiency of their workflow

  18. ADVANCED TURBINE SYSTEMS PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    Gregory Gaul

    2004-04-21

    Natural gas combustion turbines are rapidly becoming the primary technology of choice for generating electricity. At least half of the new generating capacity added in the US over the next twenty years will be combustion turbine systems. The Department of Energy has cosponsored with Siemens Westinghouse, a program to maintain the technology lead in gas turbine systems. The very ambitious eight year program was designed to demonstrate a highly efficient and commercially acceptable power plant, with the ability to fire a wide range of fuels. The main goal of the Advanced Turbine Systems (ATS) Program was to develop ultra-high efficiency, environmentally superior and cost effective competitive gas turbine systems for base load application in utility, independent power producer and industrial markets. Performance targets were focused on natural gas as a fuel and included: System efficiency that exceeds 60% (lower heating value basis); Less than 10 ppmv NO{sub x} emissions without the use of post combustion controls; Busbar electricity that are less than 10% of state of the art systems; Reliability-Availability-Maintainability (RAM) equivalent to current systems; Water consumption minimized to levels consistent with cost and efficiency goals; and Commercial systems by the year 2000. In a parallel effort, the program was to focus on adapting the ATS engine to coal-derived or biomass fuels. In Phase 1 of the ATS Program, preliminary investigators on different gas turbine cycles demonstrated that net plant LHV based efficiency greater than 60% was achievable. In Phase 2 the more promising cycles were evaluated in greater detail and the closed-loop steam-cooled combined cycle was selected for development because it offered the best solution with least risk for achieving the ATS Program goals for plant efficiency, emissions, cost of electricity and RAM. Phase 2 also involved conceptual ATS engine and plant design and technology developments in aerodynamics, sealing

  19. Multiple piece turbine airfoil

    Science.gov (United States)

    Kimmel, Keith D; Wilson, Jr., Jack W.

    2010-11-02

    A turbine airfoil, such as a rotor blade or a stator vane, for a gas turbine engine, the airfoil formed as a shell and spar construction with a plurality of dog bone struts each mounted within openings formed within the shell and spar to allow for relative motion between the spar and shell in the airfoil chordwise direction while also forming a seal between adjacent cooling channels. The struts provide the seal as well as prevent bulging of the shell from the spar due to the cooling air pressure.

  20. Aerodynamics of wind turbines

    CERN Document Server

    Hansen, Martin O L

    2015-01-01

    Aerodynamics of Wind Turbines is the established essential text for the fundamental solutions to efficient wind turbine design. Now in its third edition, it has been substantially updated with respect to structural dynamics and control. The new control chapter now includes details on how to design a classical pitch and torque regulator to control rotational speed and power, while the section on structural dynamics has been extended with a simplified mechanical system explaining the phenomena of forward and backward whirling modes. Readers will also benefit from a new chapter on Vertical Axis W

  1. Ceramic gas turbine shroud

    Science.gov (United States)

    Shi, Jun; Green, Kevin E.

    2014-07-22

    An example gas turbine engine shroud includes a first annular ceramic wall having an inner side for resisting high temperature turbine engine gasses and an outer side with a plurality of radial slots. A second annular metallic wall is positioned radially outwardly of and enclosing the first annular ceramic wall and has a plurality of tabs in communication with the slot of the first annular ceramic wall. The tabs of the second annular metallic wall and slots of the first annular ceramic wall are in communication such that the first annular ceramic wall and second annular metallic wall are affixed.

  2. Advanced hydropower turbine: AHTS-Advanced Hydropower Turbine System Program; Turbinas hidraulicas avancadas: Programa AHTS-Advanced Hydropower Turbine System

    Energy Technology Data Exchange (ETDEWEB)

    Macorin, Adriano De Figueiredo; Tomisawa, Alessandra Terumi; Van Deursen, Gustavo Jose Ferreira; Bermann, Celio [Universidade de Sao Paulo (USP), SP (Brazil)], email: brunosilva@usp.br

    2010-07-01

    Due to a privileged hydrography and energy policies that remounts to the beginning of the 20th century, Brazilian's electrical grid can be considered one of the cleanest in the world regarding the emission of atmospheric pollutants. Nevertheless, as in every human large enterprise, it is well known that hydroelectric power plants also lead to harmful environmental impacts. This article presents the AHTS Program (Advanced Hydropower Turbine System) started in 1994 in USA and developed to assess and conceive new hydro turbines to mitigate two of the main negative impacts of the installation and operation of this kind of power plant: (a) turbine-passed fish mortality and (b) the low dissolved oxygen - DO - levels downstream of the dams. The criteria used to concept the turbines are also justified in this article. As well as the modifications made in each case by the following companies: Alden Research Lab e o Northern Research and Engineering Corporation (ARL/NREC) and Voith Hydro (Voith). (author)

  3. FY 2000 report on the research cooperation project - Research cooperation in developmental support for oil producing countries. Development of the new field of usage of Orinoco oil for fuel of gas turbine combined power generation; 2000 nendo san'yukoku kaihatsu shien kenkyu kyoryoku jigyo seika hokokusho. Gasu tabin fukugo hatsuden nenryo muke Orinoko oil no shin yoto kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-09-01

    For the purpose of spreading the usage of Orinoco crude oil which is suffering from sluggishness in the export and heightening the economical efficiency in Venezuela, research cooperation was made for a project for reduction of the power cost and environmental loads in Japan by producing the advanced gas turbine use fuel oil from Orinoco oil and exporting it to Japan. In this project, conducted were the technical verification that the gas turbine use fuel oil (GTF) can be produced from Orinoco oil and the economical verification based on the result thereof. As a result of the technical verification, it was confirmed that from the Orinoco crude oil which is heavy, high in sulfur and high in heavy metal concentration, a refined oil satisfying the following properties of the advanced gas turbine fuel oil could be trial-produced using the distilling unit, SDA unit, desulfurizer and de-metaling unit: vanadium concentration: 0.5 wtppm or below; sodium + potassium concentration: 1.0 wtppm or below; viscosity: 20 cSt or below at 135 degrees C. Further, from the economical verification, the good result was obtained that the price was lower than the LNG price and the domestic price of A heavy oil/C heavy oil. (NEDO)

  4. Fish-Friendly Hydropower Turbine Development & Deployment: Alden Turbine Preliminary Engineering and Model Testing

    Energy Technology Data Exchange (ETDEWEB)

    Foust, J. [Voith Hydro, Inc., York, PA (USA); Hecker, G. [Alden Research Laboratory, Inc., Holden, MA (USA); Li, S. [Alden Research Laboratory, Inc., Holden, MA (USA); Allen, G. [Alden Research Laboratory, Inc., Holden, MA (USA)

    2011-10-01

    The Alden turbine was developed through the U.S. Department of Energy's (DOE's) former Advanced Hydro Turbine Systems Program (1994-2006) and, more recently, through the Electric Power Research Institute (EPRI) and the DOE's Wind & Water Power Program. The primary goal of the engineering study described here was to provide a commercially competitive turbine design that would yield fish passage survival rates comparable to or better than the survival rates of bypassing or spilling flow. Although the turbine design was performed for site conditions corresponding to 92 ft (28 m) net head and a discharge of 1500 cfs (42.5 cms), the design can be modified for additional sites with differing operating conditions. During the turbine development, design modifications were identified for the spiral case, distributor (stay vanes and wicket gates), runner, and draft tube to improve turbine performance while maintaining features for high fish passage survival. Computational results for pressure change rates and shear within the runner passage were similar in the original and final turbine geometries, while predicted minimum pressures were higher for the final turbine. The final turbine geometry and resulting flow environments are expected to further enhance the fish passage characteristics of the turbine. Computational results for the final design were shown to improve turbine efficiencies by over 6% at the selected operating condition when compared to the original concept. Prior to the release of the hydraulic components for model fabrication, finite element analysis calculations were conducted for the stay vanes, wicket gates, and runner to verify that structural design criteria for stress and deflections were met. A physical model of the turbine was manufactured and tested with data collected for power and efficiency, cavitation limits, runaway speed, axial and radial thrust, pressure pulsations, and wicket gate torque. All parameters were observed to fall

  5. A wind-tunnel investigation of wind-turbine wakes in different yawed and loading conditions

    Science.gov (United States)

    Bastankhah, Majid; Porté-Agel, Fernando

    2015-04-01

    Wind-turbine wakes have negative effects on wind-farm performance. They are associated with: (a) the velocity deficit, which reduces the generated power of downwind turbines; and (b) the turbulence level, which increases the fatigue loads on downwind turbines. Controlling the yaw angle of turbines can potentially improve the performance of wind farms by deflecting the wake away from downwind turbines. However, except for few studies, wakes of yawed turbines still suffer from the lack of systematic research. To fill this research gap, we performed wind-tunnel experiments in the recirculating boundary-layer wind tunnel at the WIRE Laboratory of EPFL to better understand the wakes of yawed turbines. High-resolution stereoscopic particle image-velocimetry (S-PIV) was used to measure three velocity components in a horizontal plane located downwind of a horizontal-axis, three-blade model turbine. A servo-controller was connected to the DC generator of the turbine, which allowed us to apply different loadings. The power and thrust coefficients of the turbine were also measured for each case. These power and thrust measurements together with the highly-resolved flow measurements enabled us to study different wake characteristics such as the energy entrainment from the outer flow into the wake, the wake deflection and the helicoidal tip vortices for yawed turbines.

  6. Mechanical (turbines and auxiliary equipment)

    CERN Document Server

    Sherry, A; Cruddace, AE

    2013-01-01

    Modern Power Station Practice, Volume 3: Mechanical (Turbines and Auxiliary Equipment) focuses on the development of turbines and auxiliary equipment used in power stations in Great Britain. Topics covered include thermodynamics and steam turbine theory; turbine auxiliary systems such as lubrication systems, feed water heating systems, and the condenser and cooling water plants. Miscellaneous station services, and pipework in power plants are also described. This book is comprised of five chapters and begins with an overview of thermodynamics and steam turbine theory, paying particular attenti

  7. Investigation of the possible influence of wind turbines on birds

    Energy Technology Data Exchange (ETDEWEB)

    Winkelman, J E

    1988-11-01

    An overview is given of carried out and current field studies, results and gaps with regard to bird damage caused by wind turbines. Present research aims at disturbance of the environment, chances for birds to become victims and actual number of victims. Gaps in our knowledge exist in particular with regard to victims which fall at night. Investigation of the chances for birds to become victims at night is preferable to searching night victims by daylight because of minimal chances of finding them and high labour-intensity. In general it can be said that current field research at the relation between wind turbines and birds is site-oriented. Broader research, especially aimed at the disturbance aspect, is not possible right now, because large wind turbines and wind turbine arrays are rare. 3 figs., 7 refs., 5 tabs.

  8. Wind turbine reliability :understanding and minimizing wind turbine operation and maintenance costs.

    Energy Technology Data Exchange (ETDEWEB)

    Walford, Christopher A. (Global Energy Concepts. Kirkland, WA)

    2006-03-01

    Wind turbine system reliability is a critical factor in the success of a wind energy project. Poor reliability directly affects both the project's revenue stream through increased operation and maintenance (O&M) costs and reduced availability to generate power due to turbine downtime. Indirectly, the acceptance of wind-generated power by the financial and developer communities as a viable enterprise is influenced by the risk associated with the capital equipment reliability; increased risk, or at least the perception of increased risk, is generally accompanied by increased financing fees or interest rates. This paper outlines the issues relevant to wind turbine reliability for wind turbine power generation projects. The first sections describe the current state of the industry, identify the cost elements associated with wind farm O&M and availability and discuss the causes of uncertainty in estimating wind turbine component reliability. The latter sections discuss the means for reducing O&M costs and propose O&M related research and development efforts that could be pursued by the wind energy research community to reduce cost of energy.

  9. Annoyance, detection and recognition of wind turbine noise.

    Science.gov (United States)

    Van Renterghem, Timothy; Bockstael, Annelies; De Weirt, Valentine; Botteldooren, Dick

    2013-07-01

    Annoyance, recognition and detection of noise from a single wind turbine were studied by means of a two-stage listening experiment with 50 participants with normal hearing abilities. In-situ recordings made at close distance from a 1.8-MW wind turbine operating at 22 rpm were mixed with road traffic noise, and processed to simulate indoor sound pressure levels at LAeq 40 dBA. In a first part, where people were unaware of the true purpose of the experiment, samples were played during a quiet leisure activity. Under these conditions, pure wind turbine noise gave very similar annoyance ratings as unmixed highway noise at the same equivalent level, while annoyance by local road traffic noise was significantly higher. In a second experiment, listeners were asked to identify the sample containing wind turbine noise in a paired comparison test. The detection limit of wind turbine noise in presence of highway noise was estimated to be as low as a signal-to-noise ratio of -23 dBA. When mixed with local road traffic, such a detection limit could not be determined. These findings support that noticing the sound could be an important aspect of wind turbine noise annoyance at the low equivalent levels typically observed indoors in practice. Participants that easily recognized wind-turbine(-like) sounds could detect wind turbine noise better when submersed in road traffic noise. Recognition of wind turbine sounds is also linked to higher annoyance. Awareness of the source is therefore a relevant aspect of wind turbine noise perception which is consistent with previous research. Copyright © 2013 Elsevier B.V. All rights reserved.

  10. Turbine design and application volumes 1, 2, and 3

    Science.gov (United States)

    Glassman, Arthur J. (Editor)

    1994-01-01

    NASA has an interest in turbines related primarily to aeronautics and space applications. Airbreathing turbine engines provide jet and turboshaft propulsion, as well as auxiliary power for aircraft. Propellant-driven turbines provide rocket propulsion and auxiliary power for spacecraft. Closed-cycle turbine engines using inert gases, organic fluids, and metal fluids have been studied for providing long-duration electric power for spacecraft. Other applications of interest for turbine engines include land-vehicle (cars, trucks, buses, trains, etc.) propulsion power and ground-based electrical power. In view of the turbine-system interest and efforts at Lewis Research Center, a course entitled 'Turbine Design and Application' was presented during 1968-69 as part of the In-house Graduate Study Program. The course was somewhat revised and again presented in 1972-73. Various aspects of turbine technology were covered including thermodynamic and fluid-dynamic concepts, fundamental turbine concepts, velocity diagrams, losses, blade aerodynamic design, blade cooling, mechanical design, operation, and performance. The notes written and used for the course have been revised and edited for publication. Such a publication can serve as a foundation for an introductory turbine course, a means for self-study, or a reference for selected topics. Any consistent set of units will satisfy the equations presented. Two commonly used consistent sets of units and constant values are given after the symbol definitions. These are the SI units and the U.S. customary units. A single set of equations covers both sets of units by including all constants required for the U.S. customary units and defining as unity those not required for the SI units. Three volumes are compiled into one.

  11. A progress report on DOE's advanced hydropower turbine systems program

    International Nuclear Information System (INIS)

    Sale, M.J.; Cada, G.F.; Rinehart, B.E.

    1997-01-01

    Recent hydropower research within the U.S. Department of Energy (DOE) has focused on the development of new turbine designs that can produce hydroelectricity without such adverse environmental affects as fish entrainment/impingement or degradation of water quality. In partnership with the hydropower industry, DOE's advanced turbine program issued a Request for Proposals for conceptual designs in October 1994. Two contracts were awarded for this initial program phase, work on which will be complete this year. A technical advisory committee with representatives from industry, regulatory agencies, and natural resource agencies was also formed to guide the DOE turbine research. The lack of quantitative biological performance criteria was identified by the committee as a critical knowledge gap. To fill this need, a new literature review was completed on the mechanisms of fish mortality during turbine passage (e.g., scrape/strike, shear, press change, etc.), ways that fish behavior affects their location and orientation in turbines, and how these turbine passage stresses can be measured. Thus year, new Laboratory tests will be conducted on fish response to shear, the least-well understood mechanism of stress. Additional testing of conceptual turbine designs depends on the level of federal funding for this program

  12. Great expectations: large wind turbines

    International Nuclear Information System (INIS)

    De Vries, E.

    2001-01-01

    This article focuses on wind turbine product development, and traces the background to wind turbines from the first generation 1.5 MW machines in 1995-6, plans for the second generation 3-5 MW class turbines to meet the expected boom in offshore wind projects, to the anticipated installation of a 4.5 MW turbine, and offshore wind projects planned for 2000-2002. The switch by the market leader Vestas to variable speed operation in 2000, the new product development and marketing strategy taken by the German Pro + Pro consultancy in their design of a 1.5 MW variable speed pitch control concept, the possible limiting of the size of turbines due to logistical difficulties, opportunities offered by air ships for large turbines, and the commissioning of offshore wind farms are discussed. Details of some 2-5 MW offshore wind turbine design specifications are tabulated

  13. Wind Turbine Blade

    DEFF Research Database (Denmark)

    2010-01-01

    The invention relates to a blade for a wind turbine, particularly to a blade that may be produced by an advanced manufacturing process for producing a blade with high quality structural components. Particularly, the structural components, which are preferably manufactured from fibre reinforced...

  14. Alcoa wind turbines

    Science.gov (United States)

    Ai, D. K.

    1979-01-01

    An overview of Alcoa's wind energy program is given with emphasis on the the development of a low cost, reliable Darrieus Vertical Axis Wind Turbine System. The design layouts and drawings for fabrication are now complete, while fabrication and installation to utilize the design are expected to begin shortly.

  15. Turbine imaging technology assessment

    Energy Technology Data Exchange (ETDEWEB)

    Moursund, R. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Carlson, T. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2004-12-01

    The goal of this project was to identify and evaluate imaging technologies for observing juvenile fish within a Kaplan turbine, and specifically that would enable scientists to determine mechanisms of fish injury within an operating turbine unit. This report documents the opportunities and constraints for observing juvenile fish at specific locations during turbine passage. These observations were used to make modifications to dam structures and operations to improve conditions for fish passage while maintaining or improving hydropower production. The physical and hydraulic environment that fish experience as they pass through the hydroelectric plants were studied and the regions with the greatest potential for injury were defined. Biological response data were also studied to determine the probable types of injuries sustained in the turbine intake and what types of injuries are detectable with imaging technologies. The study grouped injury-causing mechanisms into two categories: fluid (pressure/cavitation, shear, turbulence) and mechanical (strike/collision, grinding/pinching, scraping). The physical constraints of the environment, together with the likely types of injuries to fish, provided the parameters needed for a rigorous imaging technology evaluation. Types of technology evaluated included both tracking and imaging systems using acoustic technologies (such as sonar and acoustic tags) and optic technologies (such as pulsed-laser videography, which is high-speed videography using a laser as the flash). Criteria for determining image data quality such as frame rate, target detectability, and resolution were used to quantify the minimum requirements of an imaging sensor.

  16. Small hydraulic turbine drives

    Science.gov (United States)

    Rostafinski, W. A.

    1970-01-01

    Turbine, driven by the fluid being pumped, requires no external controls, is completely integrated into the flow system, and has bearings which utilize the main fluid for lubrication and cooling. Torque capabilities compare favorably with those developed by positive displacement hydraulic motors.

  17. Gas turbine drives

    Energy Technology Data Exchange (ETDEWEB)

    1981-01-01

    Developments in gas turbine drives are reviewed, e.g., low weight per unit power and thrust-weight ratio, fast availability of the maximum speed, absolute resistance to cold and to droplet formation vibrationeless run, and low exhaust gas temperatures. Applications in aeronautic engineering (turbofan), power stations, marine propulsion systems, railways and road transportation vehicles are mentioned.

  18. Gas turbine electric generator

    International Nuclear Information System (INIS)

    Nemoto, Masaaki; Yuhara, Tetsuo.

    1993-01-01

    When troubles are caused to a boundary of a gas turbine electric generator, there is a danger that water as an operation medium for secondary circuits leaks to primary circuits, to stop a plant and the plant itself can not resume. Then in the present invention, helium gases are used as the operation medium not only for the primary circuits but also for the secondary circuits, to provide so-called a direct cycle gas turbine system. Further, the operation media of the primary and secondary circuits are recycled by a compressor driven by a primary circuit gas turbine, and the turbine/compressor is supported by helium gas bearings. Then, problems of leakage of oil and water from the bearings or the secondary circuits can be solved, further, the cooling device in the secondary circuit is constituted as a triple-walled tube structure by way of helium gas, to prevent direct leakage of coolants into the reactor core even if cracks are formed to pipes. (N.H.)

  19. Integrated turbine bypass system

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, L.H.; Dickenson, R.J.; Parry, W.T.; Retzlaff, K.M.

    1982-07-01

    Turbine steam-flow bypasses have been used for years in various sizes and applications. Because of differing system requirements, their use has been more predominant in Europe than in the United States. Recently, some utilities and consulting engineers have been re-evaluating their need for various types of bypass operation in fossil-fuelled power plants.

  20. Floating offshore turbines

    DEFF Research Database (Denmark)

    Tande, John Olav Giæver; Merz, Karl; Schmidt Paulsen, Uwe

    2014-01-01

    metric of energy production per unit steel mass. Floating offshore wind turbines represent a promising technology. The successful operation of HyWind and WindFloat in full scale demonstrates a well advanced technology readiness level, where further development will go into refining the concepts, cost...