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Sample records for research natural products

  1. Plant natural products research in tuberculosis drug discovery and ...

    African Journals Online (AJOL)

    Plant natural products research in tuberculosis drug discovery and development: A situation report ... African Journal of Biotechnology ... tuberculosis (XDR-TB), call for the development of new anti-tuberculosis drugs to combat this disease.

  2. Short history of natural product research in the CSIR

    CSIR Research Space (South Africa)

    Walwyn, D

    2006-02-01

    Full Text Available Natural product research has been a major component of the CSIR's bioscience activities for its entire history, and particularly in the 1960s and 1970s. This type of work is also strongly aligned with one of the objectives of the CSIR, namely...

  3. Interdisciplinary researches for potential developments of drugs and natural products

    Directory of Open Access Journals (Sweden)

    Arunrat Chaveerach

    2017-04-01

    Full Text Available Developments of drugs or natural products from plants are possibly made, simple to use and lower cost than modern drugs. The development processes can be started with studying local wisdom and literature reviews to choose the plants which have long been used in diverse areas, such as foods, traditional medicine, fragrances and seasonings. Then those data will be associated with scientific researches, namely plant collection and identification, phytochemical screening by gas chromatography-mass spectrometry, pharmacological study/review for their functions, and finally safety and efficiency tests in human. For safety testing, in vitro cell toxicity by cell viability assessment and in vitro testing of DNA breaks by the comet assay in human peripheral blood mononuclear cells can be performed. When active chemicals and functions containing plants were chosen with safety and efficacy for human uses, then, the potential medicinal natural products will be produced. Based on these procedures, the producing cost will be cheaper and the products can be evaluated for their clinical properties. Thus, the best and lowest-priced medicines and natural products can be distributed worldwide.

  4. Interdisciplinary researches for potential developments of drugs and natural products

    Institute of Scientific and Technical Information of China (English)

    Arunrat Chaveerach; Runglawan Sudmoon; Tawatchai Tanee

    2017-01-01

    Developments of drugs or natural products from plants are possibly made,simple to use and lower cost than modern drugs.The development processes can be started with studying local wisdom and literature reviews to choose the plants which have long been used in diverse areas,such as foods,traditional medicine,fragrances and seasonings.Then those data will be associated with scientific researches,namely plant collection and identification,phytochemical screening by gas chromatography-mass spectrometry,pharmacological study/review for their functions,and finally safety and efficiency tests in human.For safety testing,in vitro cell toxicity by cell viability assessment and in vitro testing of DNA breaks by the comet assay in human peripheral blood mononuclear cells can be performed.When active chemicals and functions containing plants were chosen with safety and efficacy for human uses,then,the potential medicinal natural products will be produced.Based on these procedures,the producing cost will be cheaper and the products can be evaluated for their clinical properties.Thus,the best and lowest-priced medicines and natural products can be distributed worldwide.

  5. Natural Products Research in China from 2015 to 2016

    Science.gov (United States)

    Liu, Haishan; Zhu, Guoliang; Fan, Yaqin; Du, Yuqi; Lan, Mengmeng; Xu, Yibo; Zhu, Weiming

    2018-03-01

    This review covers the literature published by Chinese chemists from 2015 to 2016 on natural products (NPs), with 1,985 citations referring to 6,944 new compounds isolated from marine or terrestrial microorganisms, plants, and animals. The emphasis is on 730 new compounds with a novel skeleton or/and significant bioactivity, together with their source organism and country of origin.

  6. Natural Products Research in China From 2015 to 2016

    OpenAIRE

    Haishan Liu; Haishan Liu; Guoliang Zhu; Guoliang Zhu; Yaqin Fan; Yaqin Fan; Yuqi Du; Yuqi Du; Mengmeng Lan; Mengmeng Lan; Yibo Xu; Yibo Xu; Weiming Zhu; Weiming Zhu

    2018-01-01

    This review covers the literature published by chemists from China during the 2015–2016 on natural products (NPs), with 1,985 citations referring to 6,944 new compounds isolated from marine or terrestrial microorganisms, plants, and animals. The emphasis is on 730 new compounds with a novel skeleton or/and significant bioactivity, together with their source organism and country of origin.

  7. Plant natural products research in tuberculosis drug discovery and ...

    African Journals Online (AJOL)

    SAM

    2014-06-04

    Jun 4, 2014 ... Department of Medicinal Chemistry and Quality Control (MCQC), National Institute for Pharmaceutical Research and. Development ..... Anticancer. Cannabis sativa L. ... National Cancer Research Institute (NCI) at Frederick,.

  8. Natural Products Research in South Africa: End of an Era on Land or ...

    African Journals Online (AJOL)

    NICO

    single era of natural product chemistry research in South Africa but rather three ... The Specialization Era (ca. 1960–1990) ... South African Natural Products in the International Drug. Discovery .... subsequently proposed that 24 was formed through an initial ... complete elimination of M. grisea infestation by the commercial.

  9. Application of phase-trafficking methods to natural products research.

    Science.gov (United States)

    Araya, Juan J; Montenegro, Gloria; Mitscher, Lester A; Timmermann, Barbara N

    2010-09-24

    A novel simultaneous phase-trafficking approach using spatially separated solid-supported reagents for rapid separation of neutral, basic, and acidic compounds from organic plant extracts with minimum labor is reported. Acidic and basic ion-exchange resins were physically separated into individual sacks ("tea bags") for trapping basic and acidic compounds, respectively, leaving behind in solution neutral components of the natural mixtures. Trapped compounds were then recovered from solid phase by appropriate suspension in acidic or basic solutions. The feasibility of the proposed separation protocol was demonstrated and optimized with an "artificial mixture" of model compounds. In addition, the utility of this methodology was illustrated with the successful separation of the alkaloid skytanthine from Skytanthus acutus Meyen and the main catechins and caffeine from Camellia sinensis L. (Kuntze). This novel approach offers multiple advantages over traditional extraction methods, as it is not labor intensive, makes use of only small quantities of solvents, produces fractions in adequate quantities for biological assays, and can be easily adapted to field conditions for bioprospecting activities.

  10. Natural Products Research in South Africa: End of an Era on Land or ...

    African Journals Online (AJOL)

    South African organic chemistry is deeply rooted in a rich history of natural product chemistry research with the secondary metabolites emanating from South Africa's unique floral kingdoms dominating this research for nearly a century. However, South Africa's terrestrial biodiversity is exceeded by an even greater diversity of ...

  11. Review on research of suppression male fertility and male contraceptive drug development by natural products.

    Science.gov (United States)

    Bajaj, Vijay Kumar; Gupta, Radhey S

    2013-08-01

    Male contraceptive development in the present scenario is most viable aspect of research due to uncontrolled population growth in the world. In this respect investigators are busy to find out a safe male contraceptive drug. Researchers have started their finding for a suitable drug from natural sources because these are safe and easily acceptable for common man, most of natural sources are plants and their products. In this review 137 plants and their effects on reproduction and reproductive physiology are summarized. Some of them have intense effect on male reproductive system and do not produce any side effects. Reproductive toxicological studies are also important aspects of these kinds of researches, so it is important that drugs are safe and widely acceptable. An ideal male contraceptive can influence semen, testes, hormone level, accessory reproductive organs and general physiology of animals and produced some alterations. Many plants in this review are showing antifertility as well as antispermatogenic effects, so these may be used for further study for contraceptives development but it is important to find out the mechanism of reaction and further laboratory and clinical research on some plants are needed for final male contraceptive drug development. In conclusion this review will help for finding suitable plant products for male contraceptive clinical and laboratory studies.

  12. Investigation of efficient {sup 131}I production from natural uranium at Tehran research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Khalafi, H. [Nuclear Research Center, AEOI, No. 54 North Kargar Avenue, P.O. Box 14155/1339, Tehran (Iran, Islamic Republic of)]. E-mail: hossein_khalafi@yahoo.com; Nazari, K. [Jaber-Ibne-Hayan Research laboratories, AEOI, P.O. Box 11365/8486, Tehran (Iran, Islamic Republic of); Ghannadi-Maragheh, M. [Jaber-Ibne-Hayan Research laboratories, AEOI, P.O. Box 11365/8486, Tehran (Iran, Islamic Republic of)

    2005-05-15

    Iodine-131, which has a half-life of 8.05 days, is the one of the most widely used radionuclides in medical diagnosis and treats some diseases of thyroid gland. Optimization of {sup 131}I production in Tehran research reactor (TRR) was studied by two different methods. Primarily, standard nuclear codes such as ORIGEN, WIMS and CITATION were applied and then analytical solutions technique was followed. Calculated results and experimental works in the bench scale indicate that, by irradiation of 100 g natural Uranium (UO{sub 2}) for 100 h at 3.5 x 10{sup 13} (n's/cm{sup 2} s) thermal neutron flux in the TRR, one can produce about 5 Ci of {sup 131}I for medical purposes, on the other hand can produce very useful radionuclides like {sup 99}Mo and {sup 133}Xe in one batch irradiation in the unique production line.

  13. Investigation of efficient 131I production from natural uranium at Tehran research reactor

    International Nuclear Information System (INIS)

    Khalafi, H.; Nazari, K.; Ghannadi-Maragheh, M.

    2005-01-01

    Iodine-131, which has a half-life of 8.05 days, is the one of the most widely used radionuclides in medical diagnosis and treats some diseases of thyroid gland. Optimization of 131 I production in Tehran research reactor (TRR) was studied by two different methods. Primarily, standard nuclear codes such as ORIGEN, WIMS and CITATION were applied and then analytical solutions technique was followed. Calculated results and experimental works in the bench scale indicate that, by irradiation of 100 g natural Uranium (UO 2 ) for 100 h at 3.5 x 10 13 (n's/cm 2 s) thermal neutron flux in the TRR, one can produce about 5 Ci of 131 I for medical purposes, on the other hand can produce very useful radionuclides like 99 Mo and 133 Xe in one batch irradiation in the unique production line

  14. Natural products against cancer: A comprehensive bibliometric study of the research projects, publications, patents and drugs

    Directory of Open Access Journals (Sweden)

    Jian Du

    2014-01-01

    Full Text Available Objectives: To analyze multi-source data including awards, publications, patents and drugs, and try to draw the whole landscape of the research and development community in the area of natural products (NPs against cancer. Materials and Methods: Awards, publications, patents and drugs data from National Institute of Health/Natural Science Foundation of China (NIH/NSFC, PubMed, Derwent Innovation Index and Cortellis were collected. Bibliometric methodologies and technology are used to investigate publications/patents/drugs, their contents and relationships. Results: NIH and NSFC respectively demonstrated a stable and sustained expenditure growth in this area. The number of publications is continuously increasing. Yet the annual patent applications worldwide and FDA drug approvals were little changed or not obviously fluctuated in 2003-2013. USA and several Asia-pacific countries/territories are important contributing powers. We described the evolution of major research topics by those MeSH Major Topics indexed in PubMed with the largest growth range in three intervals, and analyzed hot research topics in the recent 10 years which include NPs or NPs derivatives, cell line/animal model, laboratory technologies and activation mechanisms. Conclusions: China published the most publications and received the most patent applications, but drug discovery performance is no better than USA and Japan. Research on anti-neoplastic structures and compounds originated from Chinese traditional medicine (TCM, medicinal plants, herbal medicine and marine NPs are major research topics in the recent 10 years. There still exits translational gap between basic research and drug discovery. Translational research should be undertaken to strengthen the applicability of NPs.

  15. Nephrotoxicity of Natural Products.

    Science.gov (United States)

    Nauffal, Mary; Gabardi, Steven

    2016-01-01

    The manufacture and sale of natural products constitute a multi-billion dollar industry. Nearly a third of the American population admit to using some form of complementary or alternative medicine, with many using them in addition to prescription medications. Most patients fail to inform their healthcare providers of their natural product use and physicians rarely inquire. Annually, thousands of natural product-induced adverse events are reported to Poison Control Centers nationwide. Natural product manufacturers are not responsible for proving safety and efficacy, as the FDA does not regulate them. However, concerns exist surrounding the safety of natural products. This review provides details on natural products that have been associated with renal dysfunction. We have focused on products that have been associated with direct renal injury, immune-mediated nephrotoxicity, nephrolithiasis, rhabdomyolysis with acute renal injury, hepatorenal syndrome, and common adulterants or contaminants that are associated with renal dysfunction. The potential for natural products to cause renal dysfunction is justifiable. It is imperative that natural product use be monitored closely in all patients. Healthcare practitioners must play an active role in identifying patients using natural products and provide appropriate patient education. © 2016 S. Karger AG, Basel.

  16. 21st century natural product research and drug development and traditional medicines.

    Science.gov (United States)

    Ngo, Linh T; Okogun, Joseph I; Folk, William R

    2013-04-01

    Natural products and related structures are essential sources of new pharmaceuticals, because of the immense variety of functionally relevant secondary metabolites of microbial and plant species. Furthermore, the development of powerful analytical tools based upon genomics, proteomics, metabolomics, bioinformatics and other 21st century technologies are greatly expediting identification and characterization of these natural products. Here we discuss the synergistic and reciprocal benefits of linking these 'omics technologies with robust ethnobotanical and ethnomedical studies of traditional medicines, to provide critically needed improved medicines and treatments that are inexpensive, accessible, safe and reliable. However, careless application of modern technologies can challenge traditional knowledge and biodiversity that are the foundation of traditional medicines. To address such challenges while fulfilling the need for improved (and new) medicines, we encourage the development of Regional Centres of 'omics Technologies functionally linked with Regional Centres of Genetic Resources, especially in regions of the world where use of traditional medicines is prevalent and essential for health.

  17. A Natural Love of Natural Products

    OpenAIRE

    Kingston, David G. I.

    2008-01-01

    Recent research on the chemistry of natural products from the author?s group that led to the receipt of the ACS Ernest Guenther Award in the Chemistry of Natural Products is reviewed. REDOR NMR and synthetic studies established the T-taxol conformation as the bioactive tubulin-binding conformation, and these results were confirmed by the synthesis of compounds which clearly owed their activity or lack of activity to whether or not they could adopt the T-taxol conformation. Similar studies wit...

  18. Statistical Research on the Bioactivity of New Marine Natural Products Discovered during the 28 Years from 1985 to 2012

    Science.gov (United States)

    Hu, Yiwen; Chen, Jiahui; Hu, Guping; Yu, Jianchen; Zhu, Xun; Lin, Yongcheng; Chen, Shengping; Yuan, Jie

    2015-01-01

    Every year, hundreds of new compounds are discovered from the metabolites of marine organisms. Finding new and useful compounds is one of the crucial drivers for this field of research. Here we describe the statistics of bioactive compounds discovered from marine organisms from 1985 to 2012. This work is based on our database, which contains information on more than 15,000 chemical substances including 4196 bioactive marine natural products. We performed a comprehensive statistical analysis to understand the characteristics of the novel bioactive compounds and detail temporal trends, chemical structures, species distribution, and research progress. We hope this meta-analysis will provide useful information for research into the bioactivity of marine natural products and drug development. PMID:25574736

  19. Antiplasmodial Natural Products

    Directory of Open Access Journals (Sweden)

    Cláudio R. Nogueira

    2011-03-01

    Full Text Available Malaria is a human infectious disease that is caused by four species of Plasmodium. It is responsible for more than 1 million deaths per year. Natural products contain a great variety of chemical structures and have been screened for antiplasmodial activity as potential sources of new antimalarial drugs. This review highlights studies on natural products with antimalarial and antiplasmodial activity reported in the literature from January 2009 to November 2010. A total of 360 antiplasmodial natural products comprised of terpenes, including iridoids, sesquiterpenes, diterpenes, terpenoid benzoquinones, steroids, quassinoids, limonoids, curcubitacins, and lanostanes; flavonoids; alkaloids; peptides; phenylalkanoids; xanthones; naphthopyrones; polyketides, including halenaquinones, peroxides, polyacetylenes, and resorcylic acids; depsidones; benzophenones; macrolides; and miscellaneous compounds, including halogenated compounds and chromenes are listed in this review.

  20. A plug-and-play pathway refactoring workflow for natural product research in Escherichia coli and Saccharomyces cerevisiae.

    Science.gov (United States)

    Ren, Hengqian; Hu, Pingfan; Zhao, Huimin

    2017-08-01

    Pathway refactoring serves as an invaluable synthetic biology tool for natural product discovery, characterization, and engineering. However, the complicated and laborious molecular biology techniques largely hinder its application in natural product research, especially in a high-throughput manner. Here we report a plug-and-play pathway refactoring workflow for high-throughput, flexible pathway construction, and expression in both Escherichia coli and Saccharomyces cerevisiae. Biosynthetic genes were firstly cloned into pre-assembled helper plasmids with promoters and terminators, resulting in a series of expression cassettes. These expression cassettes were further assembled using Golden Gate reaction to generate fully refactored pathways. The inclusion of spacer plasmids in this system would not only increase the flexibility for refactoring pathways with different number of genes, but also facilitate gene deletion and replacement. As proof of concept, a total of 96 pathways for combinatorial carotenoid biosynthesis were built successfully. This workflow should be generally applicable to different classes of natural products produced by various organisms. Biotechnol. Bioeng. 2017;114: 1847-1854. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  1. Ethnobotany as a pharmacological research tool and recent developments in CNS-active natural products from ethnobotanical sources.

    Science.gov (United States)

    McClatchey, Will C; Mahady, Gail B; Bennett, Bradley C; Shiels, Laura; Savo, Valentina

    2009-08-01

    The science of ethnobotany is reviewed in light of its multi-disciplinary contributions to natural product research for the development of pharmaceuticals and pharmacological tools. Some of the issues reviewed involve ethical and cultural perspectives of healthcare and medicinal plants. While these are not usually part of the discussion of pharmacology, cultural concerns potentially provide both challenges and insight for field and laboratory researchers. Plant evolutionary issues are also considered as they relate to development of plant chemistry and accessing this through ethnobotanical methods. The discussion includes presentation of a range of CNS-active medicinal plants that have been recently examined in the field, laboratory and/or clinic. Each of these plants is used to illustrate one or more aspects about the valuable roles of ethnobotany in pharmacological research. We conclude with consideration of mutually beneficial future collaborations between field ethnobotanists and pharmacologists.

  2. Natural products as photoprotection.

    Science.gov (United States)

    Saewan, Nisakorn; Jimtaisong, Ampa

    2015-03-01

    The rise in solar ultraviolet radiation on the earth's surface has led to a depletion of stratospheric ozone over recent decades, thus accelerating the need to protect human skin against the harmful effects of UV radiation such as erythema, edema, hyperpigmentation, photoaging, and skin cancer. There are many different ways to protect skin against UV radiation's harmful effects. The most popular way to reduce the amount of UV radiation penetrating the skin is topical application of sunscreen products that contain UV absorbing or reflecting active molecules. Based on their protection mechanism, the active molecules in sunscreens are broadly divided into inorganic and organic agents. Inorganic sunscreens reflect and scatter UV and visible radiation, while organic sunscreens absorb UV radiation and then re-emit energy as heat or light. These synthetic molecules have limited concentration according to regulation concern. Several natural compounds with UV absorption property have been used to substitute for or to reduce the quantity of synthetic sunscreen agents. In addition to UV absorption property, most natural compounds were found to act as antioxidants, anti-inflammatory, and immunomodulatory agents, which provide further protection against the damaging effects of UV radiation exposure. Compounds derived from natural sources have gained considerable attention for use in sunscreen products and have bolstered the market trend toward natural cosmetics. This adds to the importance of there being a wide selection of active molecules in sunscreen formulations. This paper summarizes a number of natural products derived from propolis, plants, algae, and lichens that have shown potential photoprotection properties against UV radiation exposure-induced skin damage. © 2015 Wiley Periodicals, Inc.

  3. Natural Products and HIV/AIDS.

    Science.gov (United States)

    Cary, Daniele C; Peterlin, B Matija

    2018-01-01

    The study of natural products in biomedical research is not a modern concept. Many of the most successful medical therapeutics are derived from natural products, including those studied in the field of HIV/AIDS. Biomedical research has a rich history of discovery based on screens of medicinal herbs and traditional medicine practices. Compounds derived from natural products, which repress HIV and those that activate latent HIV, have been reported. It is important to remember the tradition in medical research to derive therapies based on these natural products and to overcome the negative perception of natural products as an "alternative medicine."

  4. Rebalancing food production and nature conservation; the need for design-oriented research

    NARCIS (Netherlands)

    Rossing, W.A.H.; Sabatier, R.; Teillard, F.; Groot, J.C.J.; Tittonell, P.A.

    2016-01-01

    The unprecedented impacts of humans on the Earth (e.g. Rockström et al., 2009; Sachs et al., 2010; Foley, 2011) have prompted a debate on the future of land use and, with agriculture as the major anthropogenic use, on new models of agricultural production. In addition to concerns about the eects of

  5. Estimation of "9"9Mo production rates from natural molybdenum in research reactors

    International Nuclear Information System (INIS)

    Blaauw, M.; Chakrova, Y.; Jacimovic, R.; Kling, A.

    2017-01-01

    Molybdenum-99 is one of the most important radionuclides for medical diagnostics. In 2015, the International Atomic Energy Agency organized a round-robin exercise where the participants measured and calculated specific saturation activities achievable for the "9"8Mo(n,γ)"9"9Mo reaction. This reaction is of interest as a means to locally, and on a small scale, produce "9"9Mo from natural molybdenum. The current paper summarises a set of experimental results and reviews the methodology for calculating the corresponding saturation activities. Activation by epithermal neutrons and also epithermal neutron self-shielding are found to be of high importance in this case. (author)

  6. NMR-based metabolomics and hyphenated NMR techniques – a perfect match in natural products research

    DEFF Research Database (Denmark)

    Vinther, Joachim Møllesøe; Wubshet, Sileshi Gizachew; Stærk, Dan

    2015-01-01

    therapeutics across a range of conditions including CNS disorders, cancer, bone and joint health and parasitic diseases. The final part is devoted to regional perspectives covering all continents, providing a state-of-the –art assessment of the status of ethnopharmacological research globally....

  7. Preliminary definition of the design of a nuclear reactor for research and radioisotope production using natural uranium and heavy water

    International Nuclear Information System (INIS)

    Llagostera Beltran, J.I.

    1982-01-01

    A study was conducted about the evolution of the Brazilian importations of radioisotopes, from the beginning of the 70's since they have been increasingly used in the Country. In view of the limited production capacity of radioactive isotopes now existing in Brazil, a nuclear reactor type (natural uranium and heavy water) was defined, for research and production of radioisotopes, wich, besides providing, at least partially, the Brazilian needs of said isotopes, permits a large national participation in its project, construction and operating maintenance. The processes for heavy water production have been analyzed and it could be detected what is the best alternative for the production thereof, in low scale, in Brazil. The options concerning the definition of the main components of the reactor were justified and its most important features were determined, in relation to the neutronic and thermal aspects, being so defined its most significant parameters. The annual quantities were estimated, in terms of total and specific activity, for the radioisotopes that could be obtained by means of the proposed reactor, which, by now, are participating, to a large extent, in the total of Brazilian importation of radioactive isotopes. (Author) [pt

  8. Sustainability or Colonialism? Legislative obstacles to research and development of natural products and patents on traditional knowledge in Brazil

    Directory of Open Access Journals (Sweden)

    Camilo Tomazini Pedrollo

    2015-09-01

    Full Text Available ABSTRACTHistorically, developed countries have benefited from the biodiversity and traditional knowledge of developing countries. Since the Convention on Biological Diversity (CBD was approved, the world-view regarding access to biological resources has changed. This change marked the introduction of legal agreements regarding access to genetic resources, traditional knowledge and benefit sharing, seeking a fair return for owners and local communities. Unfortunately, as with most national laws, these legal devices complicated collection programs and research initiatives, and diminished the emphasis on the discovery of natural products. There remains a lack of discussion on the establishment of a fair international market value for the access to genetic resources. While Brazil still has advantages and opportunities in this arena, the issue sets barriers for research and development. The protective measures are being reviewed in the project bill 7735/2014, which brings improvements, yet it is still controversial. For this short communication we consulted journals, conference proceedings, as well as scientific and journalistic magazines to report some of the disastrous consequences of the implementation of national laws regarding CBD. We suggest a new focus for decision-making policies based on more efficient field inspections, the empowerment of traditional communities and further associated research in order to ensure the claims of CBD as well as to ratify the Nagoya Protocol.

  9. Combinatorial synthesis of natural products

    DEFF Research Database (Denmark)

    Nielsen, John

    2002-01-01

    Combinatorial syntheses allow production of compound libraries in an expeditious and organized manner immediately applicable for high-throughput screening. Natural products possess a pedigree to justify quality and appreciation in drug discovery and development. Currently, we are seeing a rapid...... increase in application of natural products in combinatorial chemistry and vice versa. The therapeutic areas of infectious disease and oncology still dominate but many new areas are emerging. Several complex natural products have now been synthesised by solid-phase methods and have created the foundation...... for preparation of combinatorial libraries. In other examples, natural products or intermediates have served as building blocks or scaffolds in the synthesis of complex natural products, bioactive analogues or designed hybrid molecules. Finally, structural motifs from the biologically active parent molecule have...

  10. ASM Inaugural Lecture 2010: Single crystal X-ray structural determination: A powerful technique for natural products research and drug discovery

    International Nuclear Information System (INIS)

    Fun Hoong Kun; Chantrapromma, S.; Boonnak, N.; Lee, V.S.

    2010-01-01

    Drug discovery from natural products resources have been extensively studied worldwide because natural products with their great structural diversity have traditionally provided most of the drugs in use. They offer major opportunities for finding novel low molecular weight leading-structures that are active against a wide range of assay targets. The most important step in the discovery process is the identification of compounds with interesting biological activity. Single crystal X-ray structure determination is a powerful technique for natural products research and drug discovery. The detailed three-dimensional structures that emerge can be co-related to the activities to these structures. In this article the following is presented: (i) co-crystal and disorder structures; (ii) determination of absolute configuration and (iii) the ability to distinguish between whether a natural product compound is a natural product or a natural product artifact. All these three properties are unique to the technique of single crystal X-ray structure determination. Case (iii) was demonstrated with a compound containing a chromene ring, namely macluraxanthone (which was isolated from Cratoxylum formosum subsp. pruniflorum, a Thai medicinal plant). (author)

  11. A ten-year audit of traditional Chinese medicine and other natural product research published in the Chinese Medical Journal (2000-2009)

    Institute of Scientific and Technical Information of China (English)

    Richard A. Collins

    2011-01-01

    Background Clinical research encompasses a wide variety of disciplines. Traditional Chinese medicine (TCM) and natural product research have made great contributions to preventing and treating illness. The number and content of original research reports evaluating TCM and natural products have not previously been described. Information in this area will identify areas of relative strength and weakness in terms of knowledge gaps with respect to clinical conditions and natural product remedies.Methods Original research reports (i.e. original articles, brief reports, and research letters) published in the Chinese Medical Journal (CMJ) from January 2000 to December 2009 evaluating TCM and other natural products were reviewed.The United Kingdom Clinical Research Collaboration (UK-CRC) Health Research Classification System was used to analyze the type of health research conducted. Further analysis on the major illnesses addressed and the major herbal components utilized was conducted.Results One hundred and seventeen original research reports involving TCM or other natural products were identified,comprising 3.82% of the CMJ output in the period covered by this study. Of the different materia medica described in these reports, 74.4% were derived exclusively from plant material, 10.3% from animals, 3.4% from fungi, 1.7% from minerals, and 10.3% were of mixed (plant / animal / fungal / mineral) composition. Twelve herbs were investigated exclusively or were constituents of 66/87 (75.9%) of the plant-based materia medica investigated. Panax ginseng was the most commonly investigated herb or constituent (14/87, 16.1%), followed by Astragalus membranaceus (9/87, 10.3%),Coptis chinensis/Berberis spp. (7/87, 8.0%) and Rheum spp. (7/87, 8.0%). Four UK-CRC health categories accounted for the majority of TCM and other natural product research (cancer, 20.9%; cardiovascular, 19.2%; oral/gastrointestinal,9.8%; and inflammatory/immune, 9.0%). The most common research activity was

  12. New Synthetic Methods for Hypericum Natural Products

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Insik [Iowa State Univ., Ames, IA (United States)

    2006-01-01

    Organic chemistry has served as a solid foundation for interdisciplinary research areas, such as molecular biology and medicinal chemistry. An understanding of the biological activities and structural elucidations of natural products can lead to the development of clinically valuable therapeutic options. The advancements of modern synthetic methodologies allow for more elaborate and concise natural product syntheses. The theme of this study centers on the synthesis of natural products with particularly challenging structures and interesting biological activities. The synthetic expertise developed here will be applicable to analog syntheses and to other research problems.

  13. Bioactive natural products from novel microbial sources.

    Science.gov (United States)

    Challinor, Victoria L; Bode, Helge B

    2015-09-01

    Despite the importance of microbial natural products for human health, only a few bacterial genera have been mined for the new natural products needed to overcome the urgent threat of antibiotic resistance. This is surprising, given that genome sequencing projects have revealed that the capability to produce natural products is not a rare feature among bacteria. Even the bacteria occurring in the human microbiome produce potent antibiotics, and thus potentially are an untapped resource for novel compounds, potentially with new activities. This review highlights examples of bacteria that should be considered new sources of natural products, including anaerobes, pathogens, and symbionts of humans, insects, and nematodes. Exploitation of these producer strains, combined with advances in modern natural product research methodology, has the potential to open the way for a new golden age of microbial therapeutics. © 2015 New York Academy of Sciences.

  14. Super Natural II--a database of natural products.

    Science.gov (United States)

    Banerjee, Priyanka; Erehman, Jevgeni; Gohlke, Björn-Oliver; Wilhelm, Thomas; Preissner, Robert; Dunkel, Mathias

    2015-01-01

    Natural products play a significant role in drug discovery and development. Many topological pharmacophore patterns are common between natural products and commercial drugs. A better understanding of the specific physicochemical and structural features of natural products is important for corresponding drug development. Several encyclopedias of natural compounds have been composed, but the information remains scattered or not freely available. The first version of the Supernatural database containing ∼ 50,000 compounds was published in 2006 to face these challenges. Here we present a new, updated and expanded version of natural product database, Super Natural II (http://bioinformatics.charite.de/supernatural), comprising ∼ 326,000 molecules. It provides all corresponding 2D structures, the most important structural and physicochemical properties, the predicted toxicity class for ∼ 170,000 compounds and the vendor information for the vast majority of compounds. The new version allows a template-based search for similar compounds as well as a search for compound names, vendors, specific physical properties or any substructures. Super Natural II also provides information about the pathways associated with synthesis and degradation of the natural products, as well as their mechanism of action with respect to structurally similar drugs and their target proteins. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  15. Natural products used for diabetes.

    Science.gov (United States)

    Shapiro, Karen; Gong, William C

    2002-01-01

    To review the efficacy and safety of natural products commonly used for diabetes. English and Spanish-language journals retrieved through a MEDLINE search of articles published between 1960 and December 2001 using these index terms: Opuntia, karela, gymnema, tecoma, alpha lipoic acid, thioctic acid, ginseng, panaxans, and diabetes. Natural products have long been used in traditional systems of medicine for diabetes. Products in common use include nopal (prickly pear cactus), fenu-greek, karela (bitter melon), gymnema, ginseng, tronadora, chromium, and alpha-lipoic acid. The popularity of these products varies among people of different ethnicities. Nopal is the most commonly used herbal hypoglycemic among persons of Mexican descent. Karela is more commonly used by persons from Asian countries. Some of these agents have gained universal appeal. For a select number of products, studies have revealed single or multiple mechanisms of action. For several of these, high soluble fiber content is a contributing factor. Based on the available evidence, several natural products in common use can lower blood glucose in patients with diabetes. Commonly used natural products often have a long history of traditional use, and pharmacists who have a stronger understanding of these products are better positioned to counsel patients on their appropriate use.

  16. Synthesis of Polycyclic Natural Products

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Tuan Hoang [Iowa State Univ., Ames, IA (United States)

    2003-01-01

    With the continuous advancements in molecular biology and modern medicine, organic synthesis has become vital to the support and extension of those discoveries. The isolations of new natural products allow for the understanding of their biological activities and therapeutic value. Organic synthesis is employed to aid in the determination of the relationship between structure and function of these natural products. The development of synthetic methodologies in the course of total syntheses is imperative for the expansion of this highly interdisciplinary field of science. In addition to the practical applications of total syntheses, the structural complexity of natural products represents a worthwhile challenge in itself. The pursuit of concise and efficient syntheses of complex molecules is both gratifying and enjoyable.

  17. Natural Products in the Discovery of Agrochemicals.

    Science.gov (United States)

    Loiseleur, Olivier

    2017-12-01

    Natural products have a long history of being used as, or serving as inspiration for, novel crop protection agents. Many of the discoveries in agrochemical research in the last decades have their origin in a wide range of natural products from a variety of sources. In light of the continuing need for new tools to address an ever-changing array of fungal, weed and insect pests, new agricultural practices and evolving regulatory requirements, the needs for new agrochemical tools remains as critical as ever. In that respect, nature continues to be an important source for novel chemical structures and biological mechanisms to be applied for the development of pest control agents. Here we review several of the natural products and their derivatives which contributed to shape crop protection research in past and present.

  18. Animal Production Research Advances

    African Journals Online (AJOL)

    Animal Production Research Advances is a peer-review journal established expressly to promote the production of all animal species utilized as food. The journal has an international scope and is intended for professionals in animal production and related sciences. We solicit contributions from animal production and ...

  19. Applications of natural products in the control of mosquito ...

    African Journals Online (AJOL)

    Applications of natural products in the control of mosquito-transmitted ... African Journal of Biotechnology ... Ultimately, a paradigm shift in research that evaluates natural products in a comparative manner will help to produce new materials for ...

  20. Natural Products from Mangrove Actinomycetes

    Directory of Open Access Journals (Sweden)

    Dong-Bo Xu

    2014-05-01

    Full Text Available Mangroves are woody plants located in tropical and subtropical intertidal coastal regions. The mangrove ecosystem is becoming a hot spot for natural product discovery and bioactivity survey. Diverse mangrove actinomycetes as promising and productive sources are worth being explored and uncovered. At the time of writing, we report 73 novel compounds and 49 known compounds isolated from mangrove actinomycetes including alkaloids, benzene derivatives, cyclopentenone derivatives, dilactones, macrolides, 2-pyranones and sesquiterpenes. Attractive structures such as salinosporamides, xiamycins and novel indolocarbazoles are highlighted. Many exciting compounds have been proven as potential new antibiotics, antitumor and antiviral agents, anti-fibrotic agents and antioxidants. Furthermore, some of their biosynthetic pathways have also been revealed. This review is an attempt to consolidate and summarize the past and the latest studies on mangrove actinomycetes natural product discovery and to draw attention to their immense potential as novel and bioactive compounds for marine drugs discovery.

  1. Natural Products from Mangrove Actinomycetes

    Science.gov (United States)

    Xu, Dong-Bo; Ye, Wan-Wan; Han, Ying; Deng, Zi-Xin; Hong, Kui

    2014-01-01

    Mangroves are woody plants located in tropical and subtropical intertidal coastal regions. The mangrove ecosystem is becoming a hot spot for natural product discovery and bioactivity survey. Diverse mangrove actinomycetes as promising and productive sources are worth being explored and uncovered. At the time of writing, we report 73 novel compounds and 49 known compounds isolated from mangrove actinomycetes including alkaloids, benzene derivatives, cyclopentenone derivatives, dilactones, macrolides, 2-pyranones and sesquiterpenes. Attractive structures such as salinosporamides, xiamycins and novel indolocarbazoles are highlighted. Many exciting compounds have been proven as potential new antibiotics, antitumor and antiviral agents, anti-fibrotic agents and antioxidants. Furthermore, some of their biosynthetic pathways have also been revealed. This review is an attempt to consolidate and summarize the past and the latest studies on mangrove actinomycetes natural product discovery and to draw attention to their immense potential as novel and bioactive compounds for marine drugs discovery. PMID:24798926

  2. Flow chemistry syntheses of natural products.

    Science.gov (United States)

    Pastre, Julio C; Browne, Duncan L; Ley, Steven V

    2013-12-07

    The development and application of continuous flow chemistry methods for synthesis is a rapidly growing area of research. In particular, natural products provide demanding challenges to this developing technology. This review highlights successes in the area with an emphasis on new opportunities and technological advances.

  3. Using Genomics for Natural Product Structure Elucidation.

    Science.gov (United States)

    Tietz, Jonathan I; Mitchell, Douglas A

    2016-01-01

    Natural products (NPs) are the most historically bountiful source of chemical matter for drug development-especially for anti-infectives. With insights gleaned from genome mining, interest in natural product discovery has been reinvigorated. An essential stage in NP discovery is structural elucidation, which sheds light not only on the chemical composition of a molecule but also its novelty, properties, and derivatization potential. The history of structure elucidation is replete with techniquebased revolutions: combustion analysis, crystallography, UV, IR, MS, and NMR have each provided game-changing advances; the latest such advance is genomics. All natural products have a genetic basis, and the ability to obtain and interpret genomic information for structure elucidation is increasingly available at low cost to non-specialists. In this review, we describe the value of genomics as a structural elucidation technique, especially from the perspective of the natural product chemist approaching an unknown metabolite. Herein we first introduce the databases and programs of interest to the natural products chemist, with an emphasis on those currently most suited for general usability. We describe strategies for linking observed natural product-linked phenotypes to their corresponding gene clusters. We then discuss techniques for extracting structural information from genes, illustrated with numerous case examples. We also provide an analysis of the biases and limitations of the field with recommendations for future development. Our overview is not only aimed at biologically-oriented researchers already at ease with bioinformatic techniques, but also, in particular, at natural product, organic, and/or medicinal chemists not previously familiar with genomic techniques.

  4. Nature tourism: a sustainable tourism product

    Directory of Open Access Journals (Sweden)

    Violante Martínez Quintana

    2017-11-01

    Full Text Available Nature tourism has emerged in the tourism field as a result of a logical evolution in line with public policies and academic research. After negative outcomes from traditional models first raised the alarm, the entire sector has tried to foster local development based on models of responsibility and sustainability. This article revises key concepts of nature – based tourism and shows new tendencies and the perception of cultural landscapes that are seen as tourism products. Finally, it concludes by analysing new tendencies to foster alternative nature – based tourism. It also presents a planning proposal based on a responsible and sustainable tourism model to guarantee a sustainable tourism product within the natural and cultural heritage context.

  5. Alternative solvents for natural products extraction

    CERN Document Server

    Chemat, Farid

    2014-01-01

    This book presents a complete picture of the current state-of-the-art in alternative and green solvents used for laboratory and industrial natural product extraction in terms of the latest innovations, original methods and safe products. It provides the necessary theoretical background and details on extraction, techniques, mechanisms, protocols, industrial applications, safety precautions and environmental impacts. This book is aimed at professionals from industry, academicians engaged in extraction engineering or natural product chemistry research, and graduate level students. The individual chapters complement one another, were written by respected international researchers and recognized professionals from the industry, and address the latest efforts in the field. It is also the first sourcebook to focus on the rapid developments in this field.

  6. Natural gas product and strategic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Layne, A.W.; Duda, J.R.; Zammerilli, A.M.

    1993-12-31

    Product and strategic analysis at the Department of Energy (DOE)/Morgantown Energy Technology Center (METC) crosscuts all sectors of the natural gas industry. This includes the supply, transportation, and end-use sectors of the natural-gas market. Projects in the Natural Gas Resource and Extraction supply program have been integrated into a new product focus. Product development facilitates commercialization and technology transfer through DOE/industry cost-shared research, development, and demonstration (RD&D). Four products under the Resource and Extraction program include Resource and Reserves; Low Permeability Formations; Drilling, Completion, and Stimulation: and Natural Gas Upgrading. Engineering process analyses have been performed for the Slant Hole Completion Test project. These analyses focused on evaluation of horizontal-well recovery potential and applications of slant-hole technology. Figures 2 and 3 depict slant-well in situ stress conditions and hydraulic fracture configurations. Figure 4 presents Paludal Formation coal-gas production curves used to optimize the hydraulic fracture design for the slant well. Economic analyses have utilized data generated from vertical test wells to evaluate the profitability of horizontal technology for low-permeability formations in Yuma County, Colorado, and Maverick County, Texas.

  7. Research Productivity and Academics' Conceptions of Research

    Science.gov (United States)

    Brew, Angela; Boud, David; Namgung, Sang Un; Lucas, Lisa; Crawford, Karin

    2016-01-01

    This paper asks the question: do people with different levels of research productivity and identification as a researcher think of research differently? It discusses a study that differentiated levels of research productivity among English and Australian academics working in research-intensive environments in three broad discipline areas: science,…

  8. Teaching 'natural product chemistry' in Tanzania | Buchanan ...

    African Journals Online (AJOL)

    Natural products 'historically' and 'today' have vast importance. This article describes the course 'Natural Product Chemistry', a new course in the 2011/2012 academic year in the Faculty of Natural and Applied Sciences at St. John's University of Tanzania. It reveals how the course has been applied to the African and ...

  9. Genome engineering for microbial natural product discovery.

    Science.gov (United States)

    Choi, Si-Sun; Katsuyama, Yohei; Bai, Linquan; Deng, Zixin; Ohnishi, Yasuo; Kim, Eung-Soo

    2018-03-03

    The discovery and development of microbial natural products (MNPs) have played pivotal roles in the fields of human medicine and its related biotechnology sectors over the past several decades. The post-genomic era has witnessed the development of microbial genome mining approaches to isolate previously unsuspected MNP biosynthetic gene clusters (BGCs) hidden in the genome, followed by various BGC awakening techniques to visualize compound production. Additional microbial genome engineering techniques have allowed higher MNP production titers, which could complement a traditional culture-based MNP chasing approach. Here, we describe recent developments in the MNP research paradigm, including microbial genome mining, NP BGC activation, and NP overproducing cell factory design. Copyright © 2018 Elsevier Ltd. All rights reserved.

  10. Learning Organic Chemistry Through Natural Products

    Indian Academy of Sciences (India)

    Higher Learning. ... The Series on "learning Organic Chemistry Through Natural Products". Nature is a remarkable ... skeletal structure to the interior electronic configu- ration ... Among the advantages of this approach are the fact that unlike the.

  11. Appreciation of symmetry in natural product synthesis.

    Science.gov (United States)

    Bai, Wen-Ju; Wang, Xiqing

    2017-12-13

    Covering: 2012 to June 2017This review aims to show that complex natural product synthesis can be streamlined by taking advantage of molecular symmetry. Various strategies to construct molecules with either evident or hidden symmetry are illustrated. Insights regarding the origins and adjustments of these strategies as well as inspiring new methodological developments are deliberated. When a symmetric strategy fails, the corresponding reason is analysed and an alternative approach is briefly provided. Finally, the importance of exploiting molecular symmetry and future research directions are discussed.

  12. NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening.

    Science.gov (United States)

    Thornburg, Christopher C; Britt, John R; Evans, Jason R; Akee, Rhone K; Whitt, James A; Trinh, Spencer K; Harris, Matthew J; Thompson, Jerell R; Ewing, Teresa L; Shipley, Suzanne M; Grothaus, Paul G; Newman, David J; Schneider, Joel P; Grkovic, Tanja; O'Keefe, Barry R

    2018-06-13

    The US National Cancer Institute's (NCI) Natural Product Repository is one of the world's largest, most diverse collections of natural products containing over 230,000 unique extracts derived from plant, marine, and microbial organisms that have been collected from biodiverse regions throughout the world. Importantly, this national resource is available to the research community for the screening of extracts and the isolation of bioactive natural products. However, despite the success of natural products in drug discovery, compatibility issues that make extracts challenging for liquid handling systems, extended timelines that complicate natural product-based drug discovery efforts and the presence of pan-assay interfering compounds have reduced enthusiasm for the high-throughput screening (HTS) of crude natural product extract libraries in targeted assay systems. To address these limitations, the NCI Program for Natural Product Discovery (NPNPD), a newly launched, national program to advance natural product discovery technologies and facilitate the discovery of structurally defined, validated lead molecules ready for translation will create a prefractionated library from over 125,000 natural product extracts with the aim of producing a publicly-accessible, HTS-amenable library of >1,000,000 fractions. This library, representing perhaps the largest accumulation of natural-product based fractions in the world, will be made available free of charge in 384-well plates for screening against all disease states in an effort to reinvigorate natural product-based drug discovery.

  13. An Overview of Some Natural Products with Two A-Level Science Club Natural Products Experiments

    Science.gov (United States)

    Sosabowski, Michael Hal; Olivier, George W. J.; Jawad, Hala; Maatta, Sieja

    2017-01-01

    Natural products are ubiquitous in nature but do not form a large proportion of the A-level syllabuses in the UK. In this article we briefly discuss a small selection of natural products, focusing on alcohols, aldehydes and ketones, and alkaloids. We then outline two natural product experiments that are suitable for A-level chemistry clubs or…

  14. Food production and nature conservation

    NARCIS (Netherlands)

    Gordon, Iain J.; Squire, Geoff R.; Prins, Herbert H.T.

    2016-01-01

    Feeding the world's growing human population is increasingly challenging, especially as more people adopt a western diet and lifestyle. Doing so without causing damage to nature poses an even greater challenge. This book argues that in order to create a sustainable food supply whilst conserving

  15. Natural Connections on Riemannian Product Manifolds

    OpenAIRE

    Gribacheva, Dobrinka

    2011-01-01

    A Riemannian almost product manifold with integrable almost product structure is called a Riemannian product manifold. In the present paper the natural connections on such manifolds are studied, i.e. the linear connections preserving the almost product structure and the Riemannian metric.

  16. Natural Food Additives and Preservatives for Fish-Paste Products: A Review of the Past, Present, and Future States of Research

    Directory of Open Access Journals (Sweden)

    Khawaja Muhammad Imran Bashir

    2017-01-01

    Full Text Available Fish-paste products, also known as fish cakes or surimi-based products, are worldwide favorites. Surimi, a wet protein concentrate of fish muscle, is used as an intermediate raw material to produce surimi seafood. The flavor, texture, taste, shelf-life, and market value of surimi-based products depend on the source of the fish meat, type of applied heat treatment, and additives used to prepare the surimi. While preparing surimi with chemical additives, several problems have been observed, such as a lack of unique characteristics, inferior acceptability, and poor functionality. Various types of fish-paste products have been developed by using different ingredients (e.g., vegetables, seafood, herbs and oriental medicines, grains and roots including carrots, and functional food materials. However, a systematic review of fish-paste products prepared using natural food additives has not yet been performed. Therefore, the quality characteristics of fish-paste products and their functionalities were elucidated in this study. With the increasing demand for surimi seafood products, the functional properties, physiochemical properties, and shelf-life of surimi-based products need to be improved. This review will aid the preparation of new value-added products in the surimi industry.

  17. Learning Organic Chemistry Through Natural Products

    Indian Academy of Sciences (India)

    SERIES I ARTICLE. Learning Organic Chemistry. Through Natural Products. 2. Determination of Absolute Stereochemistry. N R Krishnaswamy was initiated into the world of natural products by T R. Seshadri at University of. Delhi and has carried on the glorious traditions of his mentor. He has taught at Bangalore University,.

  18. Nigerian Journal of Natural Products and Medicine

    African Journals Online (AJOL)

    Nigerian Journal of Natural Products and Medicine is published by the Nigerian Society of Pharmacognosy, a non profit organisation established in 1982 dedicated to the promotion of Pharmacognosy, Natural Products and Traditional Medicine. It has a current circulation of about 500 to scientists in Nigeria and abroad.

  19. Cordyceps fungi: natural products, pharmacological functions and developmental products.

    Science.gov (United States)

    Zhou, Xuanwei; Gong, Zhenghua; Su, Ying; Lin, Juan; Tang, Kexuan

    2009-03-01

    Parasitic Cordyceps fungi, such as Cordyceps sinensis, is a parasitic complex of fungus and caterpillar, which has been used for medicinal purposes for centuries particularly in China, Japan and other Asian countries. This article gives a general idea of the latest developments in C. sinensis research, with regard to the active chemical components, the pharmacological effects and the research and development of products in recent years. The common names for preparations include DongChongXiaCao in Chinese, winter worm summer grass in English. It has many bioactive components, such as 3'-deoxyadenosine, cordycepic acid and Cordyceps polysaccharides. It is commonly used to replenish the kidney and soothe the lung, and for the treatment of fatigue. It also can be used to treat conditions such as night sweating, hyposexuality, hyperglycaemia, hyperlipidaemia, asthenia after severe illness, respiratory disease, renal dysfunction, renal failure, arrhythmias and other heart disease and liver disease. Because of its rarity and outstanding curative effects, several mycelia strains have been isolated from natural Cordyceps and manufactured by fermentation technology, and are commonly sold as health food products. In addition, some substitutes such as C. militaris and adulterants also have been used; therefore, quality control of C. sinensis and its products is very important to ensure their safety and efficacy. Recent research advances in the study of Cordyceps, including Cordyceps mushrooms, chemical components, pharmacological functions and developmental products, has been reviewed and discussed. Developing trends in the field have also been appraised.

  20. The Nature of Educational Research

    Science.gov (United States)

    Gillett, Simon G.

    2011-01-01

    The paper is in two parts. The first part of the paper is a critique of current methodology in educational research: scientific, critical and interpretive. The ontological and epistemological assumptions of those methodologies are described from the standpoint of John Searle's analytic philosophy. In the second part two research papers with…

  1. Marine organisms: an alternative source of potentially valuable natural products

    Directory of Open Access Journals (Sweden)

    Alphonse Kelecom

    1991-01-01

    Full Text Available This paper recalls the outcoming of marine natural products research and reviews a selection of marirne bioactive metabolites in current use together with promising trends in marine pharmacology.

  2. Natural gas production verification tests

    International Nuclear Information System (INIS)

    1992-02-01

    This Environmental Assessment (EA) has been prepared by the Department of Energy (DOE) in compliance with the requirements of the National Environmental Policy Act of 1969. The Department of Energy (DOE) proposes to fund, through a contract with Petroleum Consulting Services, Inc. of Canton, Ohio, the testing of the effectiveness of a non-water based hydraulic fracturing treatment to increase gas recovery from low-pressure, tight, fractured Devonian Shale formations. Although Devonian Shales are found in the Appalachian, Michigan, and Illinois Basins, testing will be done only in the dominant, historical five state area of established production. The objective of this proposed project is to assess the benefits of liquid carbon dioxide (CO 2 )/sand stimulations in the Devonian Shale. In addition, this project would evaluate the potential nondamaging (to the formation) properties of this unique fracturing treatment relative to the clogging or chocking of pores and fractures that act as gas flow paths to the wellbore in the target gas-producing zones of the formation. This liquid CO 2 /sand fracturing process is water-free and is expected to facilitate gas well cleanup, reduce the time required for post-stimulation cleanup, and result in improved production levels in a much shorter time than is currently experienced

  3. Liquefied natural gas tender crashworthiness research

    Science.gov (United States)

    2015-03-23

    Research is being conducted to develop technical : information needed to formulate effective natural gas fuel : tender crashworthiness standards. This research is being : performed for the Federal Railroad Administrations (FRAs) : Office of Res...

  4. Antimalarial natural products: a review

    Directory of Open Access Journals (Sweden)

    Faraz Mojab

    2012-03-01

    Results and Conclusion: There is an urgent need for the development of new treatments for malaria. Many countries have a vast precedence in the use of medicinal plants and the required knowledge spans many centuries. Although malaria is controlled in Iran, some researchers tend to study malaria and related subjects. In vitro biological tests for the detection of antimalarial activities in plant extracts are currently available. It is vital that the efficacy and safety of traditional medicines be validated and their active constituents be identified in order to establish reliable quality control measures.

  5. Communities, Livelihoods and Natural Resources : Action Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Communities, Livelihoods and Natural Resources : Action Research and Policy Change in Asia. Couverture du livre Communities, Livelihoods and Natural Resources: Action Research and Policy Change in. Directeur(s) : Stephen R. Tyler. Maison(s) d'édition : Practical Action Publishing, CRDI. 1 janvier 2006. ISBN :.

  6. Learning Organic Chemistry Through Natural Products

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 1; Issue 10. Learning Organic Chemistry Through Natural Products Architectural Designs in Molecular Constructions. N R Krishnaswamy. Series Article Volume 1 Issue 10 October 1996 pp 37-43 ...

  7. Learning Organic Chemistry Through Natural Products

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 1; Issue 2. Learning Organic Chemistry Through Natural Products Determination of Absolute Stereochemistry. N R Krishnaswamy. Series Article Volume 1 Issue 2 February 1996 pp 40-46 ...

  8. Learning Organic Chemistry Through Natural Products

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 1; Issue 7. Learning Organic Chemistry Through Natural engine Products - Structure and Biological Functions. N R Krishnaswamy. Series Article Volume 1 Issue 7 July 1996 pp 23-30 ...

  9. Antifouling Activity of Marine Natural Products

    KAUST Repository

    Qian, Pei-Yuan; Xu, Sharon Ying

    2012-01-01

    for marine industries. Marine natural products have been considered as one of the most promising sources of antifouling compounds in recent years. In antifouling compound screening processes, bioassay systems often play most critical/vital roles in screening

  10. Learning Organic Chemistry Through Natural Products

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 16; Issue 12. Learning Organic Chemistry Through Natural Products - Architectural Designs in Molecular Constructions. N R Krishnaswamy. Volume 16 Issue 12 December 2011 pp 1287-1293 ...

  11. Synthesis of natural products of therapeutic significance

    Indian Academy of Sciences (India)

    system

    2015-11-07

    Nov 7, 2015 ... potential activity, while more natural products await the ... Treaty that prohibits commercial exploitation of Antarctic resources, the development of a synthetic strategy that allows the synthesis of palmerolide A and an array of its.

  12. Antifouling Activity of Marine Natural Products

    KAUST Repository

    Qian, Pei-Yuan

    2012-01-01

    With the global ban of application of organotin-based marine coatings by International Maritime Organization in 2008, there is a practical and urgent need of identifying environmentally friendly low-toxic and nontoxic antifouling compounds for marine industries. Marine natural products have been considered as one of the most promising sources of antifouling compounds in recent years. In antifouling compound screening processes, bioassay systems often play most critical/vital roles in screening efforts. To meet various needs, a variety of bioassay systems have been developed and/or adopted in both research and commercial laboratories. In this chapter, we provide a brief outline of common bioassay procedures for both antimicrofouling and antimacrofouling assays, which can serve as a general guideline for setting up bioassay systems in laboratories engaged in antifouling compound screening. Some bioassay procedures currently practiced in various laboratories are not included in this book chapter for various reasons. Individual laboratories should modify bioassay protocols based on their research interests or needs. Nevertheless, we highly recommend the research laboratories to adapt high-throughput assays as much as possible for preliminary screening assays, followed by more complex bioassay processes using multiple target species. We argue strongly for studies in mode-of-action of antifouling compounds against settling propagules, which shall lead to discovery of molecular biomarkers (genes, proteins, receptors, or receptor system) and will allow us to design more targeted bioassay systems.

  13. Naturally Efficient Emitters: Luminescent Organometallic Complexes Derived from Natural Products

    Science.gov (United States)

    Zhang, Wen-Hua; Young, David J.

    2013-08-01

    Naturally occurring molecules offer intricate structures and functionality that are the basis of modern medicinal chemistry, but are under-represented in materials science. Herein, we review recent literature describing the use of abundant and relatively inexpensive, natural products for the synthesis of ligands for luminescent organometallic complexes used for organic light emitting diodes (OLEDs) and related technologies. These ligands are prepared from the renewable starting materials caffeine, camphor, pinene and cinchonine and, with the exception of caffeine, impart performance improvements to the emissive metal complexes and resulting OLED devices, with emission wavelengths that span the visible spectrum from blue to red. The advantages of these biologically-derived molecules include improved solution processibility and phase homogeneity, brighter luminescence, higher quantum efficiencies and lower turn-on voltages. While nature has evolved these carbon-skeletons for specific purposes, they also offer some intriguing benefits in materials science and technology.

  14. Psychoactive natural products: overview of recent developments

    Directory of Open Access Journals (Sweden)

    István Ujváry

    2014-03-01

    Full Text Available Natural psychoactive substances have fascinated the curious mind of shamans, artists, scholars and laymen since antiquity. During the twentieth century, the chemical composition of the most important psychoactive drugs, that is opium, cannabis, coca and "magic mushrooms", has been fully elucidated. The mode of action of the principal ingredients has also been deciphered at the molecular level. In the past two decades, the use of herbal drugs, such as kava, kratom and Salvia divinorum, began to spread beyond their traditional geographical and cultural boundaries. The aim of the present paper is to briefly summarize recent findings on the psychopharmacology of the most prominent psychoactive natural products. Current knowledge on a few lesser-known drugs, including bufotenine, glaucine, kava, betel, pituri, lettuce opium and kanna is also reviewed. In addition, selected cases of alleged natural (or semi-natural products are also mentioned.

  15. Review: Natural products from Genus Selaginella (Selaginellaceae

    Directory of Open Access Journals (Sweden)

    AHMAD DWI SETYAWAN

    2011-01-01

    Full Text Available Setyawan AD. 2011. Natural products from Genus Selaginella (Selaginellaceae. Nusantara Bioscience 3: 44-58. Selaginella is a potent medicinal-stuff, which contains diverse of natural products such as alkaloid, phenolic (flavonoid, and terpenoid. This species is traditionally used to cure several diseases especially for wound, after childbirth, and menstrual disorder. Biflavonoid, a dimeric form of flavonoids, is the most valuable natural products of Selaginella, which constituted at least 13 compounds, namely amentoflavone, 2',8''-biapigenin, delicaflavone, ginkgetin, heveaflavone, hinokiflavone, isocryptomerin, kayaflavone, ochnaflavone, podocarpusflavone A, robustaflavone, sumaflavone, and taiwaniaflavone. Ecologically, plants use biflavonoid to response environmental condition such as defense against pests, diseases, herbivory, and competitions; while human medically use biflavonoid especially for antioxidant, anti-inflammatory, and anti carcinogenic. Selaginella also contains valuable disaccharide, namely trehalose that has long been known for protecting from desiccation and allows surviving severe environmental stress. The compound has very prospects as molecular stabilizer in the industries based bioresources.

  16. Natural gas and production of electricity

    International Nuclear Information System (INIS)

    Defago, E.

    2005-01-01

    The forthcoming power supply shortage in Switzerland due to increasing consumption is discussed, as are the possibilities for securing the future supply. Today, the main sources are hydroelectric (roughly 55 %) and nuclear (40 %) power. The share of electricity from natural gas amounts to only 1.4 %. The possibilities of further economic production of hydropower are practically exhausted. Therefore, further electric power has to be either imported or generated from other energy sources (renewable, nuclear, fossil) in the country itself. Due to the low acceptance of nuclear energy and the limited potential of renewable energy sources, natural gas is the most favoured candidate. The advantages of distributed production in cogeneration plants are compared with the centralized production in larger plants using combined cycles. Finally, a project currently under development is presented: an existing thermal power plant fueled with heavy fuel oil shall be refurbished and converted to natural gas as the new fuel

  17. Animal Production Research Advances: Submissions

    African Journals Online (AJOL)

    Where this is not possible, authors should submit two copies of original article not yet published anywhere and accompanied with a 3.5” diskette containing the article labeled appropriately in MS Word version to: Editor–in–Chief, Animal Production Research Advances Tropical Animal Health and Production Research Lab

  18. Natural products from microbes associated with insects

    DEFF Research Database (Denmark)

    Beemelmanns, Christine; Guo, Huijuan; Rischer, Maja

    2016-01-01

    Here we review discoveries of secondary metabolites from microbes associated with insects. We mainly focus on natural products, where the ecological role has been at least partially elucidated, and/or the pharmaceutical properties evaluated, and on compounds with unique structural features. We...

  19. Natural products – learning chemistry from plants

    NARCIS (Netherlands)

    Staniek, A.; Bouwmeester, H.J.; Fraser, P.D.; Kayser, O.; Martens, S.; Tissier, A.; Krol, van der A.R.; Wessjohann, L.; Warzecha, H.

    2014-01-01

    Plant natural products (PNPs) are unique in that they represent a vast array of different structural features, ranging from relatively simple molecules to very complex ones. Given the fact that many plant secondary metabolites exhibit profound biological activity, they are frequently used as

  20. Learning Organic Chemistry Through Natural Products -12 ...

    Indian Academy of Sciences (India)

    Higher Learning. Generations of students would vouch for the fact that he has the uncanny ability to present the chemistry of natural products logically and with feeling. The most interesting chemical aspect of a molecule is its. reactivHy pattern. NR Krishnaswamy. In this part of the series, dynamic organic chemistry and.

  1. Learning Organic Chemistry Through Natural Products

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 1; Issue 5. Learning Organic Chemistry Through Natural Products From Molecular and Electronic Structures to Reactivity. N R Krishnaswamy. Series Article Volume 1 Issue 5 May 1996 pp 12-18 ...

  2. Marine Natural Products as Prototype Agrochemical Agents

    Science.gov (United States)

    Peng, Jiangnan; Shen, Xiaoyu; El Sayed, Khalid A.; Dunbar, D. C Harles; Perry, Tony L.; Wilkins, Scott P.; Hamann, Mark T.; Bobzin, Steve; Huesing, Joseph; Camp, Robin; Prinsen, Mike; Krupa, Dan; Wideman, Margaret A.

    2016-01-01

    In the interest of identifying new leads that could serve as prototype agrochemical agents, 18 structurally diverse marine-derived compounds were examined for insecticidal, herbicidal, and fungicidal activities. Several new classes of compounds have been shown to be insecticidal, herbicidal, and fungicidal, which suggests that marine natural products represent an intriguing source for the discovery of new agrochemical agents. PMID:12670165

  3. Plants as natural antioxidants for meat products

    Science.gov (United States)

    Tomović, V.; Jokanović, M.; Šojić, B.; Škaljac, S.; Ivić, M.

    2017-09-01

    The meat industry is demanding antioxidants from natural sources to replace synthetic antioxidants because of the negative health consequences or beliefs regarding some synthetic ones. Plants materials provide good alternatives. Spices and herbs, generally used for their flavouring characteristics, can be added to meat products in various forms: whole, ground, or as isolates from their extracts. These natural antioxidants contain some active compounds, which exert antioxidative potential in meat products. This antioxidant activity is most often due to phenolic acids, phenolic diterpenes, flavonoids and volatile oils. Each of these compounds often has strong H-donating activity, thus making them extremely effective antioxidants; some compounds can chelate metals and donate H to oxygen radicals, thus slowing oxidation via two mechanisms. Numerous studies have demonstrated the efficacy of natural antioxidants when used in meat products. Based on this literature review, it can be concluded that natural antioxidants are added to fresh and processed meat and meat products to delay, retard, or prevent lipid oxidation, retard development of off-flavours (rancidity), improve colour stability, improve microbiological quality and extend shelf-life, without any damage to the sensory or nutritional properties.

  4. The Rakicidin Family of Anticancer Natural Products

    DEFF Research Database (Denmark)

    Tsakos, Michail; Jacobsen, Kristian Mark; Yu, Wanwan

    2016-01-01

    Rakicidin A is a prominent member of a small class of macrocyclic lipodepsipeptide natural products that contain an electrophilic 4- amido-2,4-pentadienoate (APD) functionality. Rakicidin A displays selective growth inhibitory activity against hypoxic cancer cells as well as imatinib...

  5. Chocolate: A Marvelous Natural Product of Chemistry

    Science.gov (United States)

    Tannenbaum, Ginger

    2004-01-01

    The study of chocolate, a natural product, can be beneficial for the chemistry students as they ask frequently about the relevancy of their chemistry classes. The history of chocolate, its chemical and physical changes during processing, its composition, different crystalline forms, tempering and its viscosity are discussed.

  6. Natural product mode of action (MOA) studies: a link between natural and synthetic worlds.

    Science.gov (United States)

    La Clair, James J

    2010-07-01

    In our understanding of matter, natural products deliver plots that would stun even the best productions of the legendary filmmaker, Sergio Leone. While every decade heralds a new genre of film (as well as avenues of small-molecule discovery), natural products and their "untamed prehistoric" plots continue to dazzle the fields of biotechnology, drug discovery, fragrances, food additives and agrochemistry. This review provides an abridged synopsis of the modes of natural product action discovered within the last decade and the tools and methods used in their discovery. Their stories are united in a common theme that unveils one of the more vital aspects of chemical biological research:understanding the global activity of Nature's arsenal of secondary metabolites.

  7. Flood Fighting Products Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — A wave research basin at the ERDC Coastal and Hydraulics Laboratory has been modified specifically for testing of temporary, barrier-type, flood fighting products....

  8. Regulation of natural health products in Canada.

    Science.gov (United States)

    Smith, Alysyn; Jogalekar, Sumedha; Gibson, Adam

    2014-12-02

    In Canada, all natural health products (NHPs) are regulated by Health Canada (HC) under the Food and Drugs Act and the Natural Health Product Regulations. All authorized products undergo pre-market assessment for safety, efficacy and quality and the degree of pre-market oversight varies depending on the risk of the product. In Canada, over 70,000 products have been authorized for sale and over 2000 sites have been licensed to produce NHPs. In the management of NHPs on the Canadian market, HC employs a number of active and collaborative methods to address the most common issues such as contamination, adulteration and deceptive or misleading advertising practices. HC is currently evolving its approaches to NHPs to recognize them as part of the larger group of health products available without a prescription. As such, the regulatory responsibility for all over-the-counter (OTC) drugs, including non-prescription drugs and NHPs, has been transferred to a single federal division. As a result of this transition a number of benefits are being realized with respect to government efficiency, clarity for industry, support for new innovations and consolidated government interactions with the Canadian market. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  9. In silico Design of "Un-Natural" Natural Products

    Directory of Open Access Journals (Sweden)

    Zucko; J. ...(et al.

    2008-05-01

    Full Text Available Polyketides and non-ribosomal peptides represent a large class of structurally diverse natural products much studied over recent years because the enzymes that synthesise them, the modular polyketide synthases (PKSs and the non-ribosomal peptide synthetases (NRPSs, share striking architectural similarities that can be exploited to generate "un-natural" natural products. PKS and NRPS proteins are multifunctional, composed of a co-linear arrangement of discrete protein domains representing each enzymic activity needed for chain elongation using either carboxylic acid or amino acid building blocks. Each domain is housed within larger modules which form the complex. Polyketide and peptide antibiotics, antifungals, antivirals, cytostatics, immunosuppressants, antihypertensives, antidiabetics, antimalarials and anticholesterolemics are in clinical use. Of commercial importance are also polyketide and peptide antiparasitics, coccidiostatics,animal growth promoters and natural insecticides.Polyketides are assembled through serial condensations of activated coenzyme-A thioester monomers derived from simple organic acids such as acetate, propionate and butyrate. The choice of organic acid allows the introduction of different chiral centres into the polyketide backbone. The active sites required for condensation include an acyltransferase (AT, an acyl carrier protein (ACP and a ß-ketoacylsynthase (KS. Each condensation results in a ß-keto group that undergoes all, some or none of a series of processing steps. Active sites that perform these reactions are contained within the following domains; ketoreductase (KR, dehydratase (DH and an enoylreductase (ER. The absence of any ß-keto processing results in the incorporation of a ketone group into the growing polyketide chain, a KR alone gives rise to a hydroxyl moiety, a KR and DH produce an alkene, while the combination of KR, DH and ER domains lead to complete reduction to an alkane. Most often, the last

  10. Chemical Biology of Microbial Anticancer Natural Products

    DEFF Research Database (Denmark)

    Bladt, Tanja Thorskov; Gotfredsen, Charlotte Held

    than 100 years. New natural products (NPs) are continually discovered and with the increase in selective biological assays, previously described compounds often also display novel bioactivities, justifying their presence in novel screening efforts. Screening and discovery of compounds with activity...... towards chronic lymphocytic leukemia (CLL) cells is crucial since CLL is considered as an incurable disease. To discover novel agents that targets CLL cells is complicated. CLL cells rapidly undergo apoptosis in vitro when they are removed from their natural microenvironment, even though they are long...

  11. Natural Products and Dietary Prevention of Cancer

    Science.gov (United States)

    The concept of cancer prevention was first introduced in studies using the natural form of vitamin A in the prevention of epithelial cancers. Ever since, research on cancer prevention has grown and become a rather specialized field study. Cancer is a multistage process, and takes several years for...

  12. Utilization of Natural Products as Functional Feed

    Directory of Open Access Journals (Sweden)

    Stella Magdalena

    2013-03-01

    Full Text Available The use of antibiotics as feed additive improves performance in livestock. However, scientific data related to the use of antibiotics in feed merge spreading of bacterial resistance in animal and human bodies, therefore the usage of antibiotics in animal production is restricted. This condition raise the utilization of natural antibiotic as functional feed such as phytogenics (essential oil, flavonoid, saponin, and tannin, enzyme, probiotic, and prebiotic to improve the livestock’s performance, quality, and health. Functional feeds increase profitability in animal husbandry production and its use is feeds are expected to be functional foods that may have positive effects in human nutrition.

  13. The Traditional Medicine and Modern Medicine from Natural Products

    Directory of Open Access Journals (Sweden)

    Haidan Yuan

    2016-04-01

    Full Text Available Natural products and traditional medicines are of great importance. Such forms of medicine as traditional Chinese medicine, Ayurveda, Kampo, traditional Korean medicine, and Unani have been practiced in some areas of the world and have blossomed into orderly-regulated systems of medicine. This study aims to review the literature on the relationship among natural products, traditional medicines, and modern medicine, and to explore the possible concepts and methodologies from natural products and traditional medicines to further develop drug discovery. The unique characteristics of theory, application, current role or status, and modern research of eight kinds of traditional medicine systems are summarized in this study. Although only a tiny fraction of the existing plant species have been scientifically researched for bioactivities since 1805, when the first pharmacologically-active compound morphine was isolated from opium, natural products and traditional medicines have already made fruitful contributions for modern medicine. When used to develop new drugs, natural products and traditional medicines have their incomparable advantages, such as abundant clinical experiences, and their unique diversity of chemical structures and biological activities.

  14. The Traditional Medicine and Modern Medicine from Natural Products.

    Science.gov (United States)

    Yuan, Haidan; Ma, Qianqian; Ye, Li; Piao, Guangchun

    2016-04-29

    Natural products and traditional medicines are of great importance. Such forms of medicine as traditional Chinese medicine, Ayurveda, Kampo, traditional Korean medicine, and Unani have been practiced in some areas of the world and have blossomed into orderly-regulated systems of medicine. This study aims to review the literature on the relationship among natural products, traditional medicines, and modern medicine, and to explore the possible concepts and methodologies from natural products and traditional medicines to further develop drug discovery. The unique characteristics of theory, application, current role or status, and modern research of eight kinds of traditional medicine systems are summarized in this study. Although only a tiny fraction of the existing plant species have been scientifically researched for bioactivities since 1805, when the first pharmacologically-active compound morphine was isolated from opium, natural products and traditional medicines have already made fruitful contributions for modern medicine. When used to develop new drugs, natural products and traditional medicines have their incomparable advantages, such as abundant clinical experiences, and their unique diversity of chemical structures and biological activities.

  15. Research and Development Concerning Coalbed Natural Gas

    Energy Technology Data Exchange (ETDEWEB)

    William Ruckelshaus

    2008-09-30

    The Powder River Basin in northeastern Wyoming is one of the most active areas of coalbed natural gas (CBNG) development in the western United States. This resource provides clean energy but raises environmental concerns. Primary among these is the disposal of water that is co-produced with the gas during depressurization of the coal seam. Beginning with a few producing wells in Wyoming's Powder River Basin (PRB) in 1987, CBNG well numbers in this area increased to over 13,600 in 2004, with projected growth to 20,900 producing wells in the PRB by 2010. CBNG development is continuing apace since 2004, and CBNG is now being produced or evaluated in four other Wyoming coal basins in addition to the PRB, with roughly 3500-4000 new CBNG wells permitted statewide each year since 2004. This is clearly a very valuable source of clean fuel for the nation, and for Wyoming the economic benefits are substantial. For instance, in 2003 alone the total value of Wyoming CBNG production was about $1.5 billion, with tax and royalty income of about $90 million to counties, $140 million to the state, and $27 million to the federal government. In Wyoming, cumulative CBNG water production from 1987 through December 2004 was just over 380,000 acre-feet (2.9 billion barrels), while producing almost 1.5 trillion cubic feet (tcf) of CBNG gas statewide. Annual Wyoming CBNG water production in 2003 was 74,457 acre-feet (577 million barrels). Total production of CBNG water across all Wyoming coal fields could total roughly 7 million acre-feet (55.5 billion barrels), if all of the recoverable CBNG in the projected reserves of 31.7 tcf were produced over the coming decades. Pumping water from coals to produce CBNG has been designated a beneficial water use by the Wyoming State Engineer's Office (SEO), though recently the SEO has limited this beneficial use designation by requiring a certain gas/water production ratio. In the eastern part of the PRB where CBNG water is generally of good

  16. Natural Products Combating Neurodegeneration: Parkinson's Disease.

    Science.gov (United States)

    Solayman, Md; Islam, Md Asiful; Alam, Fahmida; Khalil, Md Ibrahim; Kamal, Mohammad Amjad; Gan, Siew Hua

    2017-01-01

    Parkinson's disease (PD) is characterized by neurodegeneration and a progressive functional impairment of the midbrain nigral dopaminergic neurons. The cause remains unknown; however, several pathological processes and central factors, such as protein aggregation, mitochondrial dysfunction, iron accumulation, neuroinflammation and oxidative stress, have been reported. The current treatment method primarily targets symptoms by using anti-Parkinson drugs such as levodopa, carbidopa, dopamine (DA) agonists, monoamine oxidase type B inhibitors and anticholinergics to replace DA. When drug therapy is not satisfactory, surgical treatments are recommended. Unfortunately, the existing conventional strategies that target PD are associated with numerous side effects and possess an economic burden. Therefore, novel therapeutic approaches that regulate the pathways leading to neuronal death and dysfunction are necessary. For many years, nature has provided the primary resource for the discovery of potential therapeutic agents. Remarkably, many natural products from medicinal plants, fruits and vegetables have been demonstrated to be efficacious anti-Parkinson agents. These products possess neuroprotective properties as a result of not only their wellrecognized anti-oxidative and anti-inflammatory activities but also their inhibitory roles regarding iron accumulation, protein misfolding and the maintenance of proteasomal degradation, as well as mitochondrial homeostasis. The aim of this review is to report the available anti-Parkinson agents based on natural products and delineate their therapeutic actions, which act on various pathways. Overall, this review emphasizes the types of natural products that are potential future resources in the treatment of PD as novel regimens or supplementary agents. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  17. The chemistry of isoindole natural products

    OpenAIRE

    Speck, Klaus; Magauer, Thomas

    2013-01-01

    Summary This review highlights the chemical and biological aspects of natural products containing an oxidized or reduced isoindole skeleton. This motif is found in its intact or modified form in indolocarbazoles, macrocyclic polyketides (cytochalasan alkaloids), the aporhoeadane alkaloids, meroterpenoids from Stachybotrys species and anthraquinone-type alkaloids. Concerning their biological activity, molecular structure and synthesis, we have limited this review to the most inspiring examples...

  18. Utilization of Natural Products as Functional Feed

    OpenAIRE

    Stella Magdalena; Natadiputri G H; Nailufar; Purwadaria T

    2013-01-01

    The use of antibiotics as feed additive improves performance in livestock. However, scientific data related to the use of antibiotics in feed merge spreading of bacterial resistance in animal and human bodies, therefore the usage of antibiotics in animal production is restricted. This condition raise the utilization of natural antibiotic as functional feed such as phytogenics (essential oil, flavonoid, saponin, and tannin), enzyme, probiotic, and prebiotic to improve the livestock’s performan...

  19. Natural cold pressed oils as cosmetic products

    Directory of Open Access Journals (Sweden)

    Małgorzata Ligęza

    2016-12-01

    Full Text Available Background. It seems that patients may ask general practitioners about natural cosmetics applied on the skin regarding their safety and suitability. Objectives. The aim of the study was to analyze natural cold pressed oils as potential cosmetic products. Material and methods. Cold pressed oils obtained from selected seeds and fruit stones were analyzed, including: chokeberry seed oil, blackcurrant seed oil, elderberry seed oil, raspberry seed oil, apricot seed oil, tomato seed oil, strawberry seed oil, broccoli seed oil, Nigella sativa seed oil, hemp oil, safflower seed oil, Silybum marianum seed oil and coconut oil. 80 adult volunteers assessed the cosmetic properties of the analyzed oils. Each of the volunteers tested 2 to 4 different oils, by applying them on the skin. In addition, patch tests with all analyzed oils were performed on 23 individuals. Results. The majority of tested oils were positively evaluated by the participants: in the opinion of the participants, oil extracted from safflower had the best appearance (100% positive opinions, coconut oil had the best smell (70% positive opinions, while black currant seed oil showed the best absorbency (85% positive opinions. No irritation was observed within the analyzed product group, albeit one allergic reaction to apricot seed oil was observed with patch testing. Conclusions . Based on the achieved results, it could be suggested that natural cold pressed oils can be applied to the skin as cosmetics. Our observations may be helpful for general practitioners when choosing natural cosmetics.

  20. Natural and accelerated bioremediation research program plan

    International Nuclear Information System (INIS)

    1995-09-01

    This draft plan describes a ten-year program to develop the scientific understanding needed to harness and develop natural and enhanced biogeochemical processes to bioremediate contaminated soils, sediments and groundwater at DOE facilities. The Office of Health and Environmental Research (OHER) developed this program plan, with advice and assistance from DOE's Office of Environmental Management (EM). The program builds on OHER's tradition of sponsoring fundamental research in the life and environmental sciences and was motivated by OHER's and Office of Energy Research's (OER's) commitment to supporting DOE's environmental management mission and the belief that bioremediation is an important part of the solution to DOE's environmental problems

  1. Low Carbon Technology Options for the Natural Gas Electricity Production

    Science.gov (United States)

    The ultimate goal of this task is to perform environmental and economic analysis of natural gas based power production technologies (different routes) to investigate and evaluate strategies for reducing emissions from the power sector. It is a broad research area. Initially, the...

  2. Nordic cooperation within natural gas research

    International Nuclear Information System (INIS)

    Edna, O.-J.

    1993-01-01

    Nordic cooperation within natural gas research is discussed. A reorganization of this cooperation has recently taken place. It is explained that common Nordic resources are now to be concentrated within 7 areas, one of which is the area of energy/industrial policies, regional policies and agriculture and forestry, all under the common heading of ''Economy''. The plan of activities within this area includes international cooperation within the European Communities, the European Energy Charter, the International Energy Agency and will involve the energy policy situation in eastern Europe and the Baltic countries, the electric power and natural gas markets in the northern countries, energy related environmental questions and Nordic energy research cooperation. Nordic research activities constitute 2% of research resources within the OECD. The basis for Nordic research cooperation (for example a common cultural background) is described, and suggestions are made as to how it should be administrated. The Nordic energy research programme for 1991-1994 embodies bioenergy and the environment, fuel cells, energy and the society, solid fuels, district heating and petroleum technology. The status report for the nordic gas market, which represents the Nordic gas companies' evaluation of the Nordic gas market, is summarized, and Nordic research activities related to gas utilization are shortly commented upon. (AB)

  3. Alternative Fuels Data Center: Conventional Natural Gas Production

    Science.gov (United States)

    Conventional Natural Gas Production to someone by E-mail Share Alternative Fuels Data Center : Conventional Natural Gas Production on Facebook Tweet about Alternative Fuels Data Center: Conventional Natural Gas Production on Twitter Bookmark Alternative Fuels Data Center: Conventional Natural Gas Production

  4. Natural Food Additives and Preservatives for Fish-Paste Products: A Review of the Past, Present, and Future States of Research

    OpenAIRE

    Bashir, Khawaja Muhammad Imran; Kim, Jin-Soo; An, Jeong Hyeon; Sohn, Jae Hak; Choi, Jae-Suk

    2017-01-01

    Fish-paste products, also known as fish cakes or surimi-based products, are worldwide favorites. Surimi, a wet protein concentrate of fish muscle, is used as an intermediate raw material to produce surimi seafood. The flavor, texture, taste, shelf-life, and market value of surimi-based products depend on the source of the fish meat, type of applied heat treatment, and additives used to prepare the surimi. While preparing surimi with chemical additives, several problems have been observed, suc...

  5. Green Extraction of Natural Products: Concept and Principles

    OpenAIRE

    Giancarlo Cravotto; Maryline Abert Vian; Farid Chemat

    2012-01-01

    The design of green and sustainable extraction methods of natural products is currently a hot research topic in the multidisciplinary area of applied chemistry, biology and technology. Herein we aimed to introduce the six principles of green-extraction, describing a multifaceted strategy to apply this concept at research and industrial level. The mainstay of this working protocol are new and innovative technologies, process intensification, agro-solvents and energy saving. The concept, princi...

  6. Natural gas production from underground nuclear explosions

    Energy Technology Data Exchange (ETDEWEB)

    1965-01-01

    A remote location in Rio Arriba County, NW. New Mexico, is being considered as the site for an experiment in the use of a nuclear explosive to increase production from a natural gas field. A feasibility study has been conducted by the El Paso Natural Gas Co., the U.S. Atomic Energy commission, and the U.S. Bureau of Mines. As presently conceived, a nuclear explosive would be set in an emplacement hole and detonated. The explosion would create a cylinder or ''chimney'' of collapsed rock, and a network of fractures extending beyond the chimney. The fractures are the key effect. These would consist of new fractures, enlargement of existing ones, and movement along planes where strata overlap. In addition, there are a number of intangible but important benefits that could accrue from the stimulating effect. Among these are the great increase in recoverable reserves and the deliverability of large volumes of gas during the periods of high demand. It is believed that this type of well stimulation may increase the total gas production of these low permeability natural gas fields by about 7 times the amounts now attainable.

  7. Natural products as potential anticonvulsants: caffeoylquinic acids.

    Science.gov (United States)

    Kim, Hyo Geun; Oh, Myung Sook

    2012-03-01

    Current anticonvulsant therapies are generally directed at symptomatic treatment by suppressing excitability within the brain. Consequently, they have adverse effects such as cognitive impairment, dependence, and abuse. The need for more effective and less toxic anticonvulsants has generated renewed interest in natural products for the treatment of convulsions. Caffeoylquinic acids (CQs) are naturally occurring phenolic acids that are distributed widely in plants. There has been increasing interest in the biological activities of CQs in diseases of the central nervous system. In this issue, Nugroho et al. give evidence for the anticonvulsive effect of a CQ-rich extract from Aster glehni Franchet et Sckmidt. They optimized the extract solvent conditions, resulting in high levels of CQs and peroxynitrite-scavenging activity. Then, they investigated the sedative and anticonvulsive effects in pentobarbital- and pentylenetetrazole-induced models in mice. The CQ-rich extract significantly inhibited tonic convulsions as assessed by onset time, tonic extent, and mortality. They suggested that the CQ-rich extract from A. glehni has potential for treating convulsions. This report provides preclinical data which may be used for the development of anticonvulsants from natural products.

  8. Anti-cancer natural products isolated from chinese medicinal herbs

    Directory of Open Access Journals (Sweden)

    Wu Guosheng

    2011-07-01

    Full Text Available Abstract In recent years, a number of natural products isolated from Chinese herbs have been found to inhibit proliferation, induce apoptosis, suppress angiogenesis, retard metastasis and enhance chemotherapy, exhibiting anti-cancer potential both in vitro and in vivo. This article summarizes recent advances in in vitro and in vivo research on the anti-cancer effects and related mechanisms of some promising natural products. These natural products are also reviewed for their therapeutic potentials, including flavonoids (gambogic acid, curcumin, wogonin and silibinin, alkaloids (berberine, terpenes (artemisinin, β-elemene, oridonin, triptolide, and ursolic acid, quinones (shikonin and emodin and saponins (ginsenoside Rg3, which are isolated from Chinese medicinal herbs. In particular, the discovery of the new use of artemisinin derivatives as excellent anti-cancer drugs is also reviewed.

  9. Natural and accelerated bioremediation research program plan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    This draft plan describes a ten-year program to develop the scientific understanding needed to harness and develop natural and enhanced biogeochemical processes to bioremediate contaminated soils, sediments and groundwater at DOE facilities. The Office of Health and Environmental Research (OHER) developed this program plan, with advice and assistance from DOE`s Office of Environmental Management (EM). The program builds on OHER`s tradition of sponsoring fundamental research in the life and environmental sciences and was motivated by OHER`s and Office of Energy Research`s (OER`s) commitment to supporting DOE`s environmental management mission and the belief that bioremediation is an important part of the solution to DOE`s environmental problems.

  10. Natural products - plenty more where that came from

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, M.

    1980-12-22

    In this article, natural products and their possible use as renewable resources are reviewed. The fermentation of corn for the production of alcohol for motor fuel is discussed and other crops for this purpose include sugar cane, cassava, sweet potato and Jerusalem artichoke. The hydrolysis of cellulose to sugars based on enzyme hydrolysis is currently being researched in the USA. Also in the USA, Melvin Calvin hopes to breed a rubber-bearing plant whose latex can be easily cracked to motor fuel. Guayule and jojoba rubber-bearing plants are also the focus of research at present. The importance of natural vegetation in the manufacturing of medicines and in the chemical and food industries is stressed. Finally products of the sea, particularly alginates and carragheenins are mentioned, but as yet, the full potential of the sea to yield renewable resources is unknown.

  11. Radioisotopes In Animal Production Research

    International Nuclear Information System (INIS)

    Eduvie, L.O.

    1994-05-01

    Animal productivity may be measured among others, in terms of two important physiological processes of reproduction and growth each of which involves a number of integrated disciplines. Both physiological processes are controlled by interactions of genotype and environment. Reproduction essentially involves complex physiological processes controlled by secretions of endocrine glands known as hormones. On the other hand growth is determined largely by availabilty of essential nutrients. In order to achieve good reproductive and growth rates adequate and constant nutrition for livestock include pasture, cereals, tubers and their by-products as well as industrial by-products. While reproduction is essential to provide the required number and replacement of livestock, growth guarantees availability of meat. Another aspect of livestock production is disease control. An animal needs a good health to adequately express its genetic make up and utilize available nutrition. Research in animal production is aimed at improving all aspects of productivity of livestock which include reproduction, growth, milk production, egg production, good semen etc. of livestock. In order to achieve this an understanding of the biochemical and physiological processes occurring in the animal itself, and in the feedstuff fed to the animal as well as the aetiology and control of diseases affecting the animal among other factors, is desirable. A number of methods of investigation have evolved with time. These include colorimetry, spectrophotometry, chromatography, microscopy and raidoisotopic tracer methods. While most of these methods are cumbersome and use equipment with low precision, radioisotopic tracer methods utilize equipment with relatively high precision

  12. Structure elucidation of secondary natural products

    International Nuclear Information System (INIS)

    Seger, C.

    2001-06-01

    The presented thesis deals with the structure elucidation of secondary natural products. Most of the compounds under investigation were terpenes, especially triterpenes, alkaloids and stilbenoids. Besides characterizing a multitude of already known and also new compounds, it was possible to detect and correct wrongly assigned literature data. The methodological aspect of this thesis lies - beside in the utilization of modern 2D NMR spectroscopy - in the evaluation of computer assisted structure elucidation (CASE) techniques in the course of spectroscopy supported structure elucidation processes. (author)

  13. Natural gas: reserves keep ahead of production

    Energy Technology Data Exchange (ETDEWEB)

    Hough, G V

    1983-08-01

    World production of natural gas in 1982 fell only 1.6% below 1981 levels, while proven recoverable reserves were up by 3.6% for a total of 3.279 quadrillion CF, which is 32.4% higher than had been estimated in 1978. Gas consumption, however, has experienced greater changes, with most of the industrialized countries (except for Japan) reporting declines in gas demand resulting from falling oil prices, reduced energy demand, and a slack world economy. Although gas seems to be holding its own in energy markets, further progress will not be easy to achieve.

  14. Natural products as radiation response modifiers

    International Nuclear Information System (INIS)

    Colin Seymour; Carmel Mothersill

    2007-01-01

    Complete text of publication follows. Protection of cells and organisms against low doses of radiation is a complex issue which must be considered at the level of cells, tissues and organisms. 'Protection' at one level, for example, prevention of cell death, may be adverse at another level, if it allows a damaged cell to survive and form a malignant tumour. Conversely, death of a cell carrying damage can be protective for the organism if it eliminates a damaged cell. Thus, it is important to understand the mechanisms involved in protection against radiation damage at several hierarchical levels. The use of natural products as radiation response modifiers is very attractive. Many of these compounds are readily available and their function and pharmacology is well understood. Some derive from venoms or natural defenses and are currently used in medicine, others include vitamins, antioxidants or cofactors, which are tried and tested nutritional supplements. Radiation effects may be targeted or untargeted. Radiation may interact directly within a cell causing a direct DNA lesion or it may elicit a bystander response from the irradiated cell. A bystander effect is produced when the irradiated cell apparently exhibits no damage from the radiation, but passes on a biochemical signal which induces neighbouring cells to apoptose or undergo a number of other responses usually associated with irradiation such as mutation induction, transformation, induction of ROS responses etc.. Effects induced in progeny of non-targeted cells in receipt of bystander signals include genetic instability, mini and microsatellite mutations and carcinogenesis. A key characteristic of these non targeted effects is that they occur at very low acute doses (of the order of 5mGy) and saturate so that effective prevention requires an agent which can effectively shut off the mechanism. While the mechanism is not fully known, it is thought to involve signals from irradiated cells communicating via

  15. Natural product derived insecticides: discovery and development of spinetoram.

    Science.gov (United States)

    Galm, Ute; Sparks, Thomas C

    2016-03-01

    This review highlights the importance of natural product research and industrial microbiology for product development in the agricultural industry, based on examples from Dow AgroSciences. It provides an overview of the discovery and development of spinetoram, a semisynthetic insecticide derived by a combination of a genetic block in a specific O-methylation of the rhamnose moiety of spinosad coupled with neural network-based QSAR and synthetic chemistry. It also emphasizes the key role that new technologies and multidisciplinary approaches play in the development of current spinetoram production strains.

  16. Amorfrutins are potent antidiabetic dietary natural products

    Science.gov (United States)

    Weidner, Christopher; de Groot, Jens C.; Prasad, Aman; Freiwald, Anja; Quedenau, Claudia; Kliem, Magdalena; Witzke, Annabell; Kodelja, Vitam; Han, Chung-Ting; Giegold, Sascha; Baumann, Matthias; Klebl, Bert; Siems, Karsten; Müller-Kuhrt, Lutz; Schürmann, Annette; Schüler, Rita; Pfeiffer, Andreas F. H.; Schroeder, Frank C.; Büssow, Konrad; Sauer, Sascha

    2012-01-01

    Given worldwide increases in the incidence of obesity and type 2 diabetes, new strategies for preventing and treating metabolic diseases are needed. The nuclear receptor PPARγ (peroxisome proliferator-activated receptor gamma) plays a central role in lipid and glucose metabolism; however, current PPARγ-targeting drugs are characterized by undesirable side effects. Natural products from edible biomaterial provide a structurally diverse resource to alleviate complex disorders via tailored nutritional intervention. We identified a family of natural products, the amorfrutins, from edible parts of two legumes, Glycyrrhiza foetida and Amorpha fruticosa, as structurally new and powerful antidiabetics with unprecedented effects for a dietary molecule. Amorfrutins bind to and activate PPARγ, which results in selective gene expression and physiological profiles markedly different from activation by current synthetic PPARγ drugs. In diet-induced obese and db/db mice, amorfrutin treatment strongly improves insulin resistance and other metabolic and inflammatory parameters without concomitant increase of fat storage or other unwanted side effects such as hepatoxicity. These results show that selective PPARγ-activation by diet-derived ligands may constitute a promising approach to combat metabolic disease. PMID:22509006

  17. Marine Natural Products as Models to Circumvent Multidrug Resistance

    Directory of Open Access Journals (Sweden)

    Solida Long

    2016-07-01

    Full Text Available Multidrug resistance (MDR to anticancer drugs is a serious health problem that in many cases leads to cancer treatment failure. The ATP binding cassette (ABC transporter P-glycoprotein (P-gp, which leads to premature efflux of drugs from cancer cells, is often responsible for MDR. On the other hand, a strategy to search for modulators from natural products to overcome MDR had been in place during the last decades. However, Nature limits the amount of some natural products, which has led to the development of synthetic strategies to increase their availability. This review summarizes the research findings on marine natural products and derivatives, mainly alkaloids, polyoxygenated sterols, polyketides, terpenoids, diketopiperazines, and peptides, with P-gp inhibitory activity highlighting the established structure-activity relationships. The synthetic pathways for the total synthesis of the most promising members and analogs are also presented. It is expected that the data gathered during the last decades concerning their synthesis and MDR-inhibiting activities will help medicinal chemists develop potential drug candidates using marine natural products as models which can deliver new ABC transporter inhibitor scaffolds.

  18. Yoghurt enrichment with natural bee farming products

    Directory of Open Access Journals (Sweden)

    N. Lomova

    2015-05-01

    Full Text Available Introduction. Bee pollen is a unique and unparalleled natural bioactive substances source. Using it in conjunction with the popular functional fermented milk product -yogurt will expand its product range and increase the biological value. Materials and Methods. Dried bee pollen’s moisture determination was made by gravimetry methods, based on the sample weight loss due to desiccation, until constant weight was reached.Test and control yogurt samples were studied by applying standard techniques for milk and milk products set forth in the regulations of Ukraine. Results and discussion. It is found that bee pollen pellet drying to a moisture content of 2 -4%, increases the flow rate of powder almost by 90%. The sample having moisture content of 2% will have a bulk density exceeding 12.5% compared to the sample having moisture content of 10%. Raw output will also increase by 3.7%. By contrast, apparent density and weight fraction of losses decreases, which has a positive impact on pollen efficiency of use and distribution in bulk yogurt. Moreover, the weight fraction of losses decreases by fourfold (4.6% vs. 1%. It was experimentally determined that pollen can deteriorate microbiological characteristics of yogurt. It was proved that treatment of crushed bee pollen pellet sample with ultraviolet allows improving yogurt microbiological safety indicators. Namely, to reduce the presence of coli-forms to 0, mould –to 10 CFU/cm³. Conclusions. The proposed bee pollen pellet treatment method will improve the technological and microbiological characteristics of pollen powder. This provides for yoghurt production biotechnology using bee farming products.

  19. Natural product synthesis at the interface of chemistry and biology

    Science.gov (United States)

    2014-01-01

    Nature has evolved to produce unique and diverse natural products that possess high target affinity and specificity. Natural products have been the richest sources for novel modulators of biomolecular function. Since the chemical synthesis of urea by Wöhler, organic chemists have been intrigued by natural products, leading to the evolution of the field of natural product synthesis over the past two centuries. Natural product synthesis has enabled natural products to play an essential role in drug discovery and chemical biology. With the introduction of novel, innovative concepts and strategies for synthetic efficiency, natural product synthesis in the 21st century is well poised to address the challenges and complexities faced by natural product chemistry and will remain essential to progress in biomedical sciences. PMID:25043880

  20. Geochemistry of actinides and fission products in natural aquifer systems

    International Nuclear Information System (INIS)

    Kim, J.I.

    1989-06-01

    The progress in the research area of the community project MIRAGE: 'Geochemistry of actinides and fission products in natural aquatic systems' has been reviewed. This programme belongs to a specific research and technical development programme for the European Atomic Energy Community in the field of management and storage of radioactive waste. The review summarizes research progresses in subject areas: complexation with organics, colloid generation in groundwater and basic retention mechanisms in the framework of the migration of radionuclides in the geosphere. The subject areas are being investigated by 23 laboratories under interlaboratory collaborations or independent studies. (orig.)

  1. Research of the Nature of Leadership Activities

    Directory of Open Access Journals (Sweden)

    Andrea Jankurová

    2017-06-01

    Full Text Available Professional literature on leadership mostly states that a leader should be like (personality traits and describes different leadership styles and types. However, very little is known about what leaders do in their everyday practice, or how they do it. Leadership should be seen more widely and should be explored along the characteristics and style of leadership and how leaders are manifested externally through their work, which means to explore the nature of leadership work. The aim of the research project was to gain more knowledge about the activities undertaken by leaders to answer a simple, but yet not too clearly answered question: „What does a leader really do?“ This finding will help reveal important activities on which best leaders focus and determine which elements are really important for leadership. The research project was managed as a combination of interviews conducted with leaders, people on senior management positions along with a questionnaire survey.

  2. Fishing for Nature's Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products.

    Science.gov (United States)

    Tabassum, Nadia; Tai, Hongmei; Jung, Da-Woon; Williams, Darren R

    2015-01-01

    Diabetes mellitus affects millions of people worldwide and significantly impacts their quality of life. Moreover, life threatening diseases, such as myocardial infarction, blindness, and renal disorders, increase the morbidity rate associated with diabetes. Various natural products from medicinal plants have shown potential as antidiabetes agents in cell-based screening systems. However, many of these potential "hits" fail in mammalian tests, due to issues such as poor pharmacokinetics and/or toxic side effects. To address this problem, the zebrafish (Danio rerio) model has been developed as a "bridge" to provide an experimentally convenient animal-based screening system to identify drug candidates that are active in vivo. In this review, we discuss the application of zebrafish to drug screening technologies for diabetes research. Specifically, the discovery of natural product-based antidiabetes compounds using zebrafish will be described. For example, it has recently been demonstrated that antidiabetic natural compounds can be identified in zebrafish using activity guided fractionation of crude plant extracts. Moreover, the development of fluorescent-tagged glucose bioprobes has allowed the screening of natural product-based modulators of glucose homeostasis in zebrafish. We hope that the discussion of these advances will illustrate the value and simplicity of establishing zebrafish-based assays for antidiabetic compounds in natural products-based laboratories.

  3. Flavin-catalyzed redox tailoring reactions in natural product biosynthesis.

    Science.gov (United States)

    Teufel, Robin

    2017-10-15

    Natural products are distinct and often highly complex organic molecules that constitute not only an important drug source, but have also pushed the field of organic chemistry by providing intricate targets for total synthesis. How the astonishing structural diversity of natural products is enzymatically generated in biosynthetic pathways remains a challenging research area, which requires detailed and sophisticated approaches to elucidate the underlying catalytic mechanisms. Commonly, the diversification of precursor molecules into distinct natural products relies on the action of pathway-specific tailoring enzymes that catalyze, e.g., acylations, glycosylations, or redox reactions. This review highlights a selection of tailoring enzymes that employ riboflavin (vitamin B2)-derived cofactors (FAD and FMN) to facilitate unusual redox catalysis and steer the formation of complex natural product pharmacophores. Remarkably, several such recently reported flavin-dependent tailoring enzymes expand the classical paradigms of flavin biochemistry leading, e.g., to the discovery of the flavin-N5-oxide - a novel flavin redox state and oxygenating species. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Chocolate: A Marvelous Natural Product of Chemistry

    Science.gov (United States)

    Tannenbaum, Ginger

    2004-08-01

    Chocolate is a natural product as ubiquitous as television. Of course, it is eaten, but it is also found in air fresheners, marking pens, flavoring in a multitude of products including soda pop, and as an aroma in "chocolate-dyed" T-shirts. However, most of us are completely unaware of the complex chemical reactions that take place to produce chocolate and the necessary technology that has evolved to produce chocolate and all its byproducts. Processing results in a mixture of many components, an interesting contrast to most of the simple, one-step reactions introduced at the high school level. This article is a survey of chocolate from tree to table. After a brief introduction to the history of chocolate and how and where it is grown, the manufacturing process is examined, and the chemistry is explored. A bit of the jargon used in the industry is mentioned. Cocoa butter is a significant ingredient in chocolate, and an investigation of it introduces triglycerides, fatty acids, polymorphic behavior, and molecular packing of the fats in chocolate and how they affect the tempering process. There is a brief discussion of chocolate's non-Newtonian behavior and the resulting challenges presented in the manufacturing process. See Featured Molecules Featured on the Cover

  5. Natural products-friends or foes?

    Science.gov (United States)

    Margină, Denisa; Ilie, Mihaela; Grădinaru, Daniela; Androutsopoulos, Vasilis P; Kouretas, Demetrios; Tsatsakis, Aristidis M

    2015-08-05

    A trend in the general population has been observed in recent years regarding the orientation toward preventive measures in health; in this context the increased interest from the users and researchers concerning the active effect of food supplements on the health state and on longevity, is noticeable. All over the world, the consumption of natural foods and of vegetal supplements has increased spectacularly over the last 5-10 years. The decreased prevalence of cardio-vascular diseases associated with Mediterranean diet, as well as the French paradox convinced researchers to scientifically document the beneficial outcomes pointed out by traditional use of plants, and to try to develop supplements that would have the same positive effects as these noticed for diet components. The intense research dedicated to this topic revealed the fact that food supplements are linked to some problematic aspects, such as toxicological side effects when associated with classical synthetic drugs. The food supplement-drug interactions are submitted to complex issues regarding pharmacokinetic interactions leading to changes in absorption, distribution, metabolism and excretion processes with direct impact on effect and toxicological potential. The present review based on recent literature aims at discussing the food-drug interactions with direct impact on efficacy and toxicity of drugs. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  6. Green extraction of natural products: concept and principles.

    Science.gov (United States)

    Chemat, Farid; Vian, Maryline Abert; Cravotto, Giancarlo

    2012-01-01

    The design of green and sustainable extraction methods of natural products is currently a hot research topic in the multidisciplinary area of applied chemistry, biology and technology. Herein we aimed to introduce the six principles of green-extraction, describing a multifaceted strategy to apply this concept at research and industrial level. The mainstay of this working protocol are new and innovative technologies, process intensification, agro-solvents and energy saving. The concept, principles and examples of green extraction here discussed, offer an updated glimpse of the huge technological effort that is being made and the diverse applications that are being developed.

  7. Green Extraction of Natural Products: Concept and Principles

    Directory of Open Access Journals (Sweden)

    Giancarlo Cravotto

    2012-07-01

    Full Text Available The design of green and sustainable extraction methods of natural products is currently a hot research topic in the multidisciplinary area of applied chemistry, biology and technology. Herein we aimed to introduce the six principles of green-extraction, describing a multifaceted strategy to apply this concept at research and industrial level. The mainstay of this working protocol are new and innovative technologies, process intensification, agro-solvents and energy saving. The concept, principles and examples of green extraction here discussed, offer an updated glimpse of the huge technological effort that is being made and the diverse applications that are being developed.

  8. Research on hydrogen production system

    International Nuclear Information System (INIS)

    Nakagiri, Toshio

    2002-07-01

    Hydrogen is closely watched for environmental issues in recent years. In this research, hydrogen production systems and production techniques are widely investigated, and selected some hydrogen production process which have high validity for FBR system. Conclusions of the investigation are shown below. (1) Water-electrolysis processes and steam reform processes at low temperatures are already realized in other fields, so they well be easily adopted for FBR system. FBR system has no advantage when compared with other systems, because water-electrolysis processes can be adopted for other electricity generation system. On the other hand, FBR system has an advantage when steam reforming processes at low temperatures will be adopted, because steam reforming processes at 550-600degC can't be adopted for LWR. (2) Thermochemical processes will be able to adopted for FBR when process temperature will be lowered and material problems solved, because their efficiencies are expected high. Radiolysis processes which use ray (for example, gamma rya) emitted in reactor can be generate hydrogen easily, so they will be able to be adopted for FBR if splitting efficiency will be higher. Further investigation and R and D to realize these processes are considered necessary. (author)

  9. Research needs on the natural gas field in Finland

    International Nuclear Information System (INIS)

    Rutanen, V.

    1992-01-01

    This report deals with the research needs on natural gas sector in Finland during the next 5-10 years. 0n that ground it has also been drafted a proposal for organization of the research and on which fields the research should be directed. The basis and criterium in this study has been on the other hand, the improvement of the possibilities in international trade of finnish companies and on the other hand the improvement of the efficiency and the reduction of the environmental impacts of energy use and production in Finland. As a result of the study it is proposed that a research entireness, which will direct extensively towards the gaseous fuels (gasification of coal and biomass, natural gas, LPG, hydrogen), will be formed. The key topics of the research would be: Production of the gases (gasification), high-efficient power and heat generation with gaseous fuels, improvement of efficiency and reduction of environmental impacts of energy use in industry with direct use of gaseous fuels and gaseous fuels in vehicles

  10. Separation process design for isolation and purification of natural products

    DEFF Research Database (Denmark)

    Malwade, Chandrakant R.

    Natural products are defined as secondary metabolites produced by plants and form a vast pool of compounds with unlimited chemical and functional diversity. Many of these secondary metabolites are high value added chemicals that are frequently used as ingredients in food, cosmetics, pharmaceuticals...... and other consumer products. Therefore, process technology towards industrial scale production of such high value chemicals from plants has significant value. Natural products can be obtained in pure form via synthetic or semi-synthetic route, but due to their complicated nature these methods have not been...... developed to the extent of industrial production for majority of natural products. Thus, isolation and purification of such natural products from plants is the most viable way to obtain natural products in pure form. This PhD project is mainly concerned with the design of separation process to isolate...

  11. Construction of a 3D-shaped, natural product like fragment library by fragmentation and diversification of natural products.

    Science.gov (United States)

    Prescher, Horst; Koch, Guido; Schuhmann, Tim; Ertl, Peter; Bussenault, Alex; Glick, Meir; Dix, Ina; Petersen, Frank; Lizos, Dimitrios E

    2017-02-01

    A fragment library consisting of 3D-shaped, natural product-like fragments was assembled. Library construction was mainly performed by natural product degradation and natural product diversification reactions and was complemented by the identification of 3D-shaped, natural product like fragments available from commercial sources. In addition, during the course of these studies, novel rearrangements were discovered for Massarigenin C and Cytochalasin E. The obtained fragment library has an excellent 3D-shape and natural product likeness, covering a novel, unexplored and underrepresented chemical space in fragment based drug discovery (FBDD). Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Pharmaceuticals from natural products: current trends

    Directory of Open Access Journals (Sweden)

    PETER R. SEIDL

    2002-03-01

    Full Text Available The use of products extracted from plants for medicinal purposes can be traced to the beginnings of civilization and up until the end of the nineteenth century natural products were the principal source of medicines. Since then their relative importance has oscillated according to the strategies of large pharmaceutical companies. Now that these strategies are changing, there are new opportunities for countries like Brazil, in which a large proportion of the world's biodiversity is located. There are, however, new circumstances that must be taken into consideration: material must be collected by groups which are formally authorized to do so and under the conditions of the Convention of Biological Diversity, the discovery process is being successively outsourced to smaller specialized firms and there is a growing integration with producers of cosmetics and phytomedicines.O uso de produtos extraídos de plantas para fins medicinais pode ser tracejado aos inícios da civilização e até o fim do século XIX, os produtos naturais constituíram a principal fonte de medicamentos. Desde então, a importância relativa dos produtos naturais tem oscilado de acordo com as estratégias de grandes companhias farmacêuticas. Agora que estas estratégias vêm mudando, há novas oportunidades para países como o Brasil, no qual está localizada uma vasta proporção da biodiversidade mundial. Há, entretanto, novas circunstâncias que devem ser levadas em consideração: o material deve ser coletado por grupos que estão formalmente autorizados para tal, com a coleta sendo feita sob as condições da Convenção de Diversidade Biológica, o processo de descoberta está sendo sucessivamente terceirizado no sentido de firmas especializadas menores e há uma integração crescente como produtores de cosméticos e fitomedicamentos.

  13. Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria.

    Science.gov (United States)

    Dittmann, Elke; Gugger, Muriel; Sivonen, Kaarina; Fewer, David P

    2015-10-01

    Cyanobacteria are an ancient lineage of slow-growing photosynthetic bacteria and a prolific source of natural products with intricate chemical structures and potent biological activities. The bulk of these natural products are known from just a handful of genera. Recent efforts have elucidated the mechanisms underpinning the biosynthesis of a diverse array of natural products from cyanobacteria. Many of the biosynthetic mechanisms are unique to cyanobacteria or rarely described from other organisms. Advances in genome sequence technology have precipitated a deluge of genome sequences for cyanobacteria. This makes it possible to link known natural products to biosynthetic gene clusters but also accelerates the discovery of new natural products through genome mining. These studies demonstrate that cyanobacteria encode a huge variety of cryptic gene clusters for the production of natural products, and the known chemical diversity is likely to be just a fraction of the true biosynthetic capabilities of this fascinating and ancient group of organisms. Copyright © 2015. Published by Elsevier Ltd.

  14. Novel fermentation processes for manufacturing plant natural products.

    Science.gov (United States)

    Zhou, Jingwen; Du, Guocheng; Chen, Jian

    2014-02-01

    Microbial production of plant natural products (PNPs), such as terpenoids, flavonoids from renewable carbohydrate feedstocks offers sustainable and economically attractive alternatives to their petroleum-based production. Rapid development of metabolic engineering and synthetic biology of microorganisms shows many advantages to replace the current extraction of these useful high price chemicals from plants. Although few of them were actually applied on a large scale for PNPs production, continuous research on these high-price chemicals and the rapid growing global market of them, show the promising future for the production of these PNPs by microorganisms with a more economic and environmental friendly way. Introduction of novel pathways and optimization of the native cellular processes by metabolic engineering of microorganisms for PNPs production are rapidly expanding its range of cell-factory applications. Here we review recent progress in metabolic engineering of microorganisms for the production of PNPs. Besides, factors restricting the yield improvement and application of lab-scale achievements to industrial applications have also been discussed. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. Cambodia Rural Livelihoods and Natural Resources Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cambodia is one of the least developed countries in Southeast Asia, with a large poor rural population dependent on natural resources for food and income. Over the past several years, the country has introduced extensive legislation related to the management of natural resources. On paper, the role of local communities ...

  16. Deposition of naturally occurring radioactivity in oil and gas production

    International Nuclear Information System (INIS)

    Lysebo, I.; Strand, T.

    1997-01-01

    This booklet contains general information about naturally occurring radioactive materials, NORM, in production of oil and natural gas, occupational doses, radiation protection procedures and measures, and classification methods of contaminated equipment. 6 refs., 1 fig., 1 tab

  17. Organosilicon Reagents in Natural Product Synthesis

    Indian Academy of Sciences (India)

    Organosilicon compounds do not occur free in nature, and are ... work was carried out by Kipping, copsidered today as the father of classical organosilicon chemistry. The ..... v V V V V v. 55 ..... Sweet potato leaf folder moth pheromone.

  18. Biosynthesis of therapeutic natural products using synthetic biology.

    Science.gov (United States)

    Awan, Ali R; Shaw, William M; Ellis, Tom

    2016-10-01

    Natural products are a group of bioactive structurally diverse chemicals produced by microorganisms and plants. These molecules and their derivatives have contributed to over a third of the therapeutic drugs produced in the last century. However, over the last few decades traditional drug discovery pipelines from natural products have become far less productive and far more expensive. One recent development with promise to combat this trend is the application of synthetic biology to therapeutic natural product biosynthesis. Synthetic biology is a young discipline with roots in systems biology, genetic engineering, and metabolic engineering. In this review, we discuss the use of synthetic biology to engineer improved yields of existing therapeutic natural products. We further describe the use of synthetic biology to combine and express natural product biosynthetic genes in unprecedented ways, and how this holds promise for opening up completely new avenues for drug discovery and production. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Linking neuroethology to the chemical biology of natural products

    DEFF Research Database (Denmark)

    Olivera, Baldomero M.; Raghuraman, Shrinivasan; Schmidt, Eric W.

    2017-01-01

    From a biological perspective, a natural product can be defined as a compound evolved by an organism for chemical interactions with another organism including prey, predator, competitor, pathogen, symbiont or host. Natural products hold tremendous potential as drug leads and have been extensively...... a better understanding of the evolution, biology and biochemistry of natural products will facilitate both neuroscience and the potential for drug leads. The larger goal is to establish a new sub-discipline in the broader field of neuroethology that we refer to as “Chemical Neuroethology”, linking...... the substantial work carried out by chemists on natural products with accelerating advances in neuroethology....

  20. Naturally occurring radionuclides in agricultural products: An overview

    International Nuclear Information System (INIS)

    Hanlon, E.A.

    1994-01-01

    Low levels of naturally occurring radionuclides exist in phosphatic clays, a by-product of phosphatic mining and beneficiation processes. Concerns about these radionuclides entering the human food chain were an immediate research priority before the phosphate clays could be reclaimed for intensive agricultural purposes. Efforts included the assembly of a large body of data from both sons and plants, part of which were produced by the Polk County (Florida) Mined Lands Agricultural Research/Demonstration Project MLAR/DP. Additional detailed studies involving dairy and beef cattle (Bos taurus) were conducted by researchers working with the MLAR/DP. A national symposium was conducted in which data concerning the MLAR/DP work and other research projects also dealing with naturally occurring radionuclides in agriculture could be discussed. The symposium included invited review papers dealing with the identification of radionuclide geological origins, the geochemistry and movement of radionuclides within the environment, mechanisms of plant uptake, entry points into the food chain, and evaluation of dose and risk assessment to the consumer of low levels of radionuclides. The risk to human health of an individual obtaining 0.1 of his or her dietary intake from crops produced on phosphatic clays increased by 1 in 5 x 10 6 /yr above a control individual consuming no food grown on phosphatic clays. Leaf tissues were found to be generally higher than fruit, grain, or root tissues. The natural range in radionuclide content among various food types was greater than the difference in radionuclides content between the same food produced on phosphatic clays vs. natural soils. 19 refs

  1. Bridging the gap: basic metabolomics methods for natural product chemistry.

    Science.gov (United States)

    Jones, Oliver A H; Hügel, Helmut M

    2013-01-01

    Natural products and their derivatives often have potent physiological activities and therefore play important roles as both frontline treatments for many diseases and as the inspiration for chemically synthesized therapeutics. However, the detection and synthesis of new therapeutic compounds derived from, or inspired by natural compounds has declined in recent years due to the increased difficulty of identifying and isolating novel active compounds. A new strategy is therefore necessary to jumpstart this field of research. Metabolomics, including both targeted and global metabolite profiling strategies, has the potential to be instrumental in this effort since it allows a systematic study of complex mixtures (such as plant extracts) without the need for prior isolation of active ingredients (or mixtures thereof). Here we describe the basic steps for conducting metabolomics experiments and analyzing the results using some of the more commonly used analytical and statistical methodologies.

  2. Research of CO2 concentration in naturally ventilated lecture room

    Science.gov (United States)

    Laska, Marta; Dudkiewicz, Edyta

    2017-11-01

    Naturally ventilated buildings especially dedicated for educational purposes need to be design to achieve required level of thermal comfort and indoor air quality. It is crucial in terms of both: health and productivity of the room users. Higher requirements of indoor environment are important due to the level of students concentration, their ability to acquire new knowledge and willingness to interact with the lecturer. The article presents the results of experimental study and surveys undertaken in naturally ventilated lecture room. The data is analysed in terms of CO2 concentration and its possible influence on users. Furthermore the outcome of the research is compared with the CO2 concentration models available in the literature.

  3. Natural Sciences and Engineering Research Council | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ca/index_eng.asp. International Research Initiative on Adaptation to Climate Change. The International Research Initiative on Adaptation to Climate Change aims to help vulnerable populations in Canada and in developing countries adapt to ...

  4. Natural resources research and management issues: 2007

    Science.gov (United States)

    Christine Vogt; James Absher; Alan Graefe; Bill Hammitt; Linda Kruger; Jerry Vaske

    2008-01-01

    This year (2007) at the Northeastern Recreation Research (NERR) Symposium, we took the opportunity to reflect on the past 15 to 20 years of recreation research and discuss the opportunities and challenges that might face us in the next decade. The session utilized a panel to entertain four primary questions focused on recreation research. Following a panel presentation...

  5. Data feature World natural Uranium production 1992

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    NUKEM estimates that world uranium production fell more than 13% last year, from 40,729 tonnes U [106 million lbs U308] in 1991 to 35,363 tonnes U [92 million lbs U308] in 1992. Production fell in both the Western World and non-Western World. How much of demand was met by production? World uranium production in 1992 amounted to about 65% of reactor consumption. That's assuming that reactor demand of the non-Western World has not changed much from the Uranium Institute's estimate for 1991. Civilian stockpiles are being drawn down on a massive scale while the world waits to see what will become of the military stockpiles that could soon enter the global supply picture

  6. Strengthening Research Capacity to Enhance Natural Resources ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... to Enhance Natural Resources Management and Improve Rural Livelihoods ... and contribute to the food and income security of the rural poor by enhancing the ... of its 2017 call for proposals to establish Cyber Policy Centres in the Global South. ... partnering on a new initiative, aimed at reducing the emerging risk that.

  7. Taxonomy, Physiology, and Natural Products of Actinobacteria

    OpenAIRE

    Barka, Essaid Ait; Vatsa, Parul; Sanchez, Lisa; Gaveau-Vaillant, Nathalie; Jacquard, Cedric; Klenk, Hans-Peter; Clément, Christophe; Ouhdouch, Yder; van Wezel, Gilles P.

    2015-01-01

    Actinobacteria are Gram-positive bacteria with high G+C DNA content that constitute one of the largest bacterial phyla, and they are ubiquitously distributed in both aquatic and terrestrial ecosystems. Many Actinobacteria have a mycelial lifestyle and undergo complex morphological differentiation. They also have an extensive secondary metabolism and produce about two-thirds of all naturally derived antibiotics in current clinical use, as well as many anticancer, anthelmintic, and antifungal c...

  8. T R Seshadri's Contributions to the Chemistry of Natural Products

    Indian Academy of Sciences (India)

    Sri Sathya Sai Institute of. Higher Learning. Generations of students would vouch for the fact that he has the uncanny ability to present the chemistry of natural products logically and with feeling. Keywords. Flavonoids, lichen metabolite, methylation, Elbs-Seshadri oxi- dation, structure elucidation, natural products synthesis.

  9. Remote methods of indicating oil products in natural waters

    Energy Technology Data Exchange (ETDEWEB)

    Shlyakhova, L A

    1981-01-01

    A survey is made of domestic and foreign publications covering remote methods of monitoring film petroleum products and oil in natural waters. The given methods are realized in practice with the use of different sections of the electromagnetic spectrum. Remote quality control of the natural waters at the modern level may be an indicator of water pollution with film petroleum products.

  10. Marine Natural Products from New Caledonia—A Review

    Directory of Open Access Journals (Sweden)

    Sofia-Eléna Motuhi

    2016-03-01

    Full Text Available Marine micro- and macroorganisms are well known to produce metabolites with high biotechnological potential. Nearly 40 years of systematic prospecting all around the New Caledonia archipelago and several successive research programs have uncovered new chemical leads from benthic and planktonic organisms. After species identification, biological and/or pharmaceutical analyses are performed on marine organisms to assess their bioactivities. A total of 3582 genera, 1107 families and 9372 species have been surveyed and more than 350 novel molecular structures have been identified. Along with their bioactivities that hold promise for therapeutic applications, most of these molecules are also potentially useful for cosmetics and food biotechnology. This review highlights the tremendous marine diversity in New Caledonia, and offers an outline of the vast possibilities for natural products, especially in the interest of pursuing collaborative fundamental research programs and developing local biotechnology programs.

  11. Phytotherapy natural products: Promotional mix features

    Directory of Open Access Journals (Sweden)

    Dugalić Sretenka L.

    2002-01-01

    Full Text Available Development of products takes into account organized and controlled planning of changes of inner self and toward the environment. That means the creation of an active force, which should bring changes in other words, it should change the person who participates in the process of creation or in the consumption of the product. It tried to induce customers to purchase through methodologies and promotion strategies which stand to our sen'ice by the change in the way of thinking of the medical and pharmaceutical profession and users of helpful means. The input of marketing within the control of the outcomes, leaders techniques and promotion strategies by the production of helpful healthy means has a very big meaning.

  12. Harnessing natural product assembly lines: structure, promiscuity, and engineering.

    Science.gov (United States)

    Ladner, Christopher C; Williams, Gavin J

    2016-03-01

    Many therapeutically relevant natural products are biosynthesized by the action of giant mega-enzyme assembly lines. By leveraging the specificity, promiscuity, and modularity of assembly lines, a variety of strategies has been developed that enables the biosynthesis of modified natural products. This review briefly summarizes recent structural advances related to natural product assembly lines, discusses chemical approaches to probing assembly line structures in the absence of traditional biophysical data, and surveys efforts that harness the inherent or engineered promiscuity of assembly lines for the synthesis of non-natural polyketides and non-ribosomal peptide analogues.

  13. Research of the Nature of Leadership Activities

    OpenAIRE

    Andrea Jankurová; Ivana Ljudvigová; Klaudia Gubová

    2017-01-01

    Professional literature on leadership mostly states that a leader should be like (personality traits) and describes different leadership styles and types. However, very little is known about what leaders do in their everyday practice, or how they do it. Leadership should be seen more widely and should be explored along the characteristics and style of leadership and how leaders are manifested externally through their work, which means to explore the nature of leadership work. The aim of the...

  14. A Causal Model of Faculty Research Productivity.

    Science.gov (United States)

    Bean, John P.

    A causal model of faculty research productivity was developed through a survey of the literature. Models of organizational behavior, organizational effectiveness, and motivation were synthesized into a causal model of productivity. Two general types of variables were assumed to affect individual research productivity: institutional variables and…

  15. Natural products: the new engine for African trade growth

    OpenAIRE

    Bennett, Ben

    2006-01-01

    This report was to further develop the trade component of the Natural Resources Enterprise Programme (NATPRO). The field work was undertaken in Malawi, Zimbabwe, Namibia, the Republic of South Africa and the United Kingdom between 9th January and 25th February 2006. The work concentrated on ten countries in Southern Africa with potential to export significant quantities of natural products. These products are defined by the project as follows: being plant derived, occurring naturally, wild ha...

  16. Production and Distribution Research Center

    Science.gov (United States)

    1986-05-01

    Steel, Coca Cola , Standard Oil of Ohio, and Martin Marietta have been involved in joint research with members of the Center. The number of Faculty...permitted the establishment of the Center and supports its continuing development. The Center has also received research sponsorship from the Joint...published relating to results developed within the PDRC under Offce of Naval Research sponsorship . These reports are listed in Appendix A. Many of these

  17. NATURAL ANTIOXIDANTS IN PRODUCTION “BRUSHWOOD”

    Directory of Open Access Journals (Sweden)

    G. N. Dubtsova

    2015-01-01

    Full Text Available Flour wares use popularity, there is 48% of general volume of pastry wares on their stake. A marketing study on results that actuality of development of new type of flour good is set with the lowered maintenance of fat and enriched by vitamins is undertaken. The use of natural antioxidant of "Guarding is reasonable toco 70" and introduction of 0,2% is recommended for stabilizing of sunflower-seed oil at fry of frying. Joint introduction of powders is studied from the garden-stuffs of brier and unabi on quality of the brushwood fried in sunflower-seed oil with the use of "Guarding toco 70". From wares extracted lipids and estimated on indexes: peroxides, acid and anizid numbers. It is set that an antioxidant and vegetable powders assist the decline of indexes of safety peroxides and asid in two times, and anizid in 1,3 time. Use of antioxidant of "Guarding toco 70", being in 70% from the natural concentrate of mixture of tocopherolss and 30% of soyaoil.

  18. A guide to understanding social science research for natural scientists.

    Science.gov (United States)

    Moon, Katie; Blackman, Deborah

    2014-10-01

    Natural scientists are increasingly interested in social research because they recognize that conservation problems are commonly social problems. Interpreting social research, however, requires at least a basic understanding of the philosophical principles and theoretical assumptions of the discipline, which are embedded in the design of social research. Natural scientists who engage in social science but are unfamiliar with these principles and assumptions can misinterpret their results. We developed a guide to assist natural scientists in understanding the philosophical basis of social science to support the meaningful interpretation of social research outcomes. The 3 fundamental elements of research are ontology, what exists in the human world that researchers can acquire knowledge about; epistemology, how knowledge is created; and philosophical perspective, the philosophical orientation of the researcher that guides her or his action. Many elements of the guide also apply to the natural sciences. Natural scientists can use the guide to assist them in interpreting social science research to determine how the ontological position of the researcher can influence the nature of the research; how the epistemological position can be used to support the legitimacy of different types of knowledge; and how philosophical perspective can shape the researcher's choice of methods and affect interpretation, communication, and application of results. The use of this guide can also support and promote the effective integration of the natural and social sciences to generate more insightful and relevant conservation research outcomes. © 2014 Society for Conservation Biology.

  19. Telomerase Inhibitors from Natural Products and Their Anticancer Potential

    Directory of Open Access Journals (Sweden)

    Kumar Ganesan

    2017-12-01

    Full Text Available Telomeres and telomerase are nowadays exploring traits on targets for anticancer therapy. Telomerase is a unique reverse transcriptase enzyme, considered as a primary factor in almost all cancer cells, which is mainly responsible to regulate the telomere length. Hence, telomerase ensures the indefinite cell proliferation during malignancy—a hallmark of cancer—and this distinctive feature has provided telomerase as the preferred target for drug development in cancer therapy. Deactivation of telomerase and telomere destabilization by natural products provides an opening to succeed new targets for cancer therapy. This review aims to provide a fundamental knowledge for research on telomere, working regulation of telomerase and its various binding proteins to inhibit the telomere/telomerase complex. In addition, the review summarizes the inhibitors of the enzyme catalytic subunit and RNA component, natural products that target telomeres, and suppression of transcriptional and post-transcriptional levels. This extensive understanding of telomerase biology will provide indispensable information for enhancing the efficiency of rational anti-cancer drug design.

  20. Some structures of marine natural products

    Energy Technology Data Exchange (ETDEWEB)

    Finer-Moore, J.S.

    1979-07-01

    Applications of x-ray crystallographic methods to marine chemistry are discussed. Results of research on a biosynthetic problem: diterpenes from Dictyotaceae are discussed under the following section headings: history of the problem; dictyoxepin; dictyodial; and dictyolactone. Studies on marine ecology are reported under the following headings: symbiosis and antibiosis; metabolites from opisthobranch molluscs, including, dolabelladiene, 9-isocyanopupukeanane and 2-isocyanopupukeanane, and crispatone; metabolites of goronians and soft corals, including zooxanthellae and the metabolism of coelenterates, ophirin, sinularene, and erectene. (JGB)

  1. MANUFACTURING NATURAL KILLER CELLS AS MEDICINAL PRODUCTS

    Directory of Open Access Journals (Sweden)

    Christian CHABANNON

    2016-11-01

    Full Text Available Natural Killer (NK cells are Innate Lymphoid Cells (ILC with cytotoxic and regulatory properties. Their functions are tightly regulated by an array of inhibitory and activating receptors, and their mechanisms of activation strongly differ from antigen recognition in the context of HLA presentation as needed for T-cell activation. NK cells thus offer unique opportunities for new and improved therapeutic manipulation, either in vivo or in vitro, in a variety of human diseases, including cancers. NK cell activity can possibly be modulated in vivo through direct or indirect actions exerted by small molecules or monoclonal antibodies. NK cells can also be adoptively transferred following more or less substantial modifications through cell and gene manufacturing, in order to empower them with new or improved functions and ensure their controlled persistence and activity in the recipient. In the present review, we will focus on the technological and regulatory challenges of NK cell manufacturing, and discuss conditions in which these innovative cellular therapies can be brought to the clinic.

  2. Taxonomy, Physiology, and Natural Products of Actinobacteria.

    Science.gov (United States)

    Barka, Essaid Ait; Vatsa, Parul; Sanchez, Lisa; Gaveau-Vaillant, Nathalie; Jacquard, Cedric; Meier-Kolthoff, Jan P; Klenk, Hans-Peter; Clément, Christophe; Ouhdouch, Yder; van Wezel, Gilles P

    2016-03-01

    Actinobacteria are Gram-positive bacteria with high G+C DNA content that constitute one of the largest bacterial phyla, and they are ubiquitously distributed in both aquatic and terrestrial ecosystems. Many Actinobacteria have a mycelial lifestyle and undergo complex morphological differentiation. They also have an extensive secondary metabolism and produce about two-thirds of all naturally derived antibiotics in current clinical use, as well as many anticancer, anthelmintic, and antifungal compounds. Consequently, these bacteria are of major importance for biotechnology, medicine, and agriculture. Actinobacteria play diverse roles in their associations with various higher organisms, since their members have adopted different lifestyles, and the phylum includes pathogens (notably, species of Corynebacterium, Mycobacterium, Nocardia, Propionibacterium, and Tropheryma), soil inhabitants (e.g., Micromonospora and Streptomyces species), plant commensals (e.g., Frankia spp.), and gastrointestinal commensals (Bifidobacterium spp.). Actinobacteria also play an important role as symbionts and as pathogens in plant-associated microbial communities. This review presents an update on the biology of this important bacterial phylum. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  3. Influenza neuraminidase: a druggable target for natural products.

    Science.gov (United States)

    Grienke, Ulrike; Schmidtke, Michaela; von Grafenstein, Susanne; Kirchmair, Johannes; Liedl, Klaus R; Rollinger, Judith M

    2012-01-01

    The imminent threat of influenza pandemics and repeatedly reported emergence of new drug-resistant influenza virus strains demonstrate the urgent need for developing innovative and effective antiviral agents for prevention and treatment. At present, influenza neuraminidase (NA), a key enzyme in viral replication, spread, and pathogenesis, is considered to be one of the most promising targets for combating influenza. Despite the substantial medical potential of NA inhibitors (NAIs), only three of these drugs are currently on the market (zanamivir, oseltamivir, and peramivir). Moreover, sudden changes in NAI susceptibility revealed the urgent need in the discovery/identification of novel inhibitors. Nature offers an abundance of biosynthesized compounds comprising chemical scaffolds of high diversity, which present an infinite pool of chemical entities for target-oriented drug discovery in the battle against this highly contagious pathogen. This review illuminates the increasing research efforts of the past decade (2000-2011), focusing on the structure, function and druggability of influenza NA, as well as its inhibition by natural products. Following a critical discussion of publications describing some 150 secondary plant metabolites tested for their inhibitory potential against influenza NA, the impact of three different strategies to identify and develop novel NAIs is presented: (i) bioactivity screening of herbal extracts, (ii) exploitation of empirical knowledge, and (iii) computational approaches. This work addresses the latest developments in theoretical and experimental research on properties of NA that are and will be driving anti-influenza drug development now and in the near future.

  4. Structure-based synthesis from natural products to drug prototypes

    International Nuclear Information System (INIS)

    Hanessian, S.

    2009-01-01

    X-Ray crystallographic data available from complexes of natural and synthetic molecules with the enzyme thrombin has aided to the design and synthesis of truncated and hybrid molecules exhibiting excellent inhibition in vitro. The vital importance of natural products for the well-being of man has been known lor millennia. Their therapeutic benefits to alleviate pain or cure diseases continue to rank natural products among the primary sources of potential drugs. Great advances have been made in the methods of isolation, identification, and structure elucidation of some of the most complex natural products in recent years. The advent of molecular biology and genetic mapping has also aided in our understanding of the intriguing biosynthetic pathways leading to various classes of therapeutically relevant antibiotic, anticancer, and related natural products. Elegant and practical methodology has been developed leading to the total synthesis of virtually every class of medicinally important natural product. In some cases, natural products or their chemically modified congeners have been manufactured by total synthesis on an industrial level which is a testament to the ingenuity of process chemists. In spite of their potent activities HI enzymatic ox receptor-mediated assays, not all natural products are amenable to being developed as marketable drags. In many instances unfavorable pharmacological effects cannot be overcome without drastic structural and functional modifications, which may also result in altered efficacy. Structure modification through truncation, functional group variations, isosteric replacements, and skeletal rigidifications aided by molecular modeling, X ray crystallography of protein targets, or NMR data are valid objectives in the context of small molecule drug discovery starting with bioactive natural products. A large proportion of these pertain to chemotherapeutic agents against cancer

  5. Nature Contact and Human Health: A Research Agenda.

    Science.gov (United States)

    Frumkin, Howard; Bratman, Gregory N; Breslow, Sara Jo; Cochran, Bobby; Kahn, Peter H; Lawler, Joshua J; Levin, Phillip S; Tandon, Pooja S; Varanasi, Usha; Wolf, Kathleen L; Wood, Spencer A

    2017-07-31

    At a time of increasing disconnectedness from nature, scientific interest in the potential health benefits of nature contact has grown. Research in recent decades has yielded substantial evidence, but large gaps remain in our understanding. We propose a research agenda on nature contact and health, identifying principal domains of research and key questions that, if answered, would provide the basis for evidence-based public health interventions. We identify research questions in seven domains: a ) mechanistic biomedical studies; b ) exposure science; c ) epidemiology of health benefits; d ) diversity and equity considerations; e ) technological nature; f ) economic and policy studies; and g ) implementation science. Nature contact may offer a range of human health benefits. Although much evidence is already available, much remains unknown. A robust research effort, guided by a focus on key unanswered questions, has the potential to yield high-impact, consequential public health insights. https://doi.org/10.1289/EHP1663.

  6. Review of natural products with hepatoprotective effects.

    Science.gov (United States)

    Madrigal-Santillán, Eduardo; Madrigal-Bujaidar, Eduardo; Álvarez-González, Isela; Sumaya-Martínez, María Teresa; Gutiérrez-Salinas, José; Bautista, Mirandeli; Morales-González, Ángel; García-Luna y González-Rubio, Manuel; Aguilar-Faisal, J Leopoldo; Morales-González, José A

    2014-10-28

    The liver is one of the most important organs in the body, performing a fundamental role in the regulation of diverse processes, among which the metabolism, secretion, storage, and detoxification of endogenous and exogenous substances are prominent. Due to these functions, hepatic diseases continue to be among the main threats to public health, and they remain problems throughout the world. Despite enormous advances in modern medicine, there are no completely effective drugs that stimulate hepatic function, that offer complete protection of the organ, or that help to regenerate hepatic cells. Thus, it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases, with the aim of these alternatives being more effective and less toxic. The use of some plants and the consumption of different fruits have played basic roles in human health care, and diverse scientific investigations have indicated that, in those plants and fruits so identified, their beneficial effects can be attributed to the presence of chemical compounds that are called phytochemicals. The present review had as its objective the collecting of data based on research conducted into some fruits (grapefruit, cranberries, and grapes) and plants [cactus pear (nopal) and cactus pear fruit, chamomile, silymarin, and spirulina], which are consumed frequently by humans and which have demonstrated hepatoprotective capacity, as well as an analysis of a resin (propolis) and some phytochemicals extracted from fruits, plants, yeasts, and algae, which have been evaluated in different models of hepatotoxicity.

  7. Review of natural products with hepatoprotective effects

    Science.gov (United States)

    Madrigal-Santillán, Eduardo; Madrigal-Bujaidar, Eduardo; Álvarez-González, Isela; Sumaya-Martínez, María Teresa; Gutiérrez-Salinas, José; Bautista, Mirandeli; Morales-González, Ángel; García-Luna y González-Rubio, Manuel; Aguilar-Faisal, J Leopoldo; Morales-González, José A

    2014-01-01

    The liver is one of the most important organs in the body, performing a fundamental role in the regulation of diverse processes, among which the metabolism, secretion, storage, and detoxification of endogenous and exogenous substances are prominent. Due to these functions, hepatic diseases continue to be among the main threats to public health, and they remain problems throughout the world. Despite enormous advances in modern medicine, there are no completely effective drugs that stimulate hepatic function, that offer complete protection of the organ, or that help to regenerate hepatic cells. Thus, it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases, with the aim of these alternatives being more effective and less toxic. The use of some plants and the consumption of different fruits have played basic roles in human health care, and diverse scientific investigations have indicated that, in those plants and fruits so identified, their beneficial effects can be attributed to the presence of chemical compounds that are called phytochemicals. The present review had as its objective the collecting of data based on research conducted into some fruits (grapefruit, cranberries, and grapes) and plants [cactus pear (nopal) and cactus pear fruit, chamomile, silymarin, and spirulina], which are consumed frequently by humans and which have demonstrated hepatoprotective capacity, as well as an analysis of a resin (propolis) and some phytochemicals extracted from fruits, plants, yeasts, and algae, which have been evaluated in different models of hepatotoxicity. PMID:25356040

  8. Beyond Research Productivity: Matching Productivity Measures to Institutional Mission

    Directory of Open Access Journals (Sweden)

    Patricia Bartholomew

    2016-11-01

    Full Text Available Aim/Purpose: The aim of this paper is to develop a unified methodology inclusive of the three primary areas of faculty responsibility (teaching, research, and service to calculate departmental productivity that fills the gap in methodological bench-marking tools for overall faculty productivity. Background:\tA disproportionate number of departmental and faculty productivity indices in higher education rely solely on research. Productivity in other areas of faculty workload areas, like teaching and institutional and community service, are either measured separately or ignored all together – even when those activities are institutionally mandated. This does a disservice to those who work in those institutions and skews incentives. Methodology: This paper utilizes a unified methodology inclusive of the three primary areas of faculty responsibility (teaching, research, and service to calculate depart-mental productivity in five disparate departments (English, Biology, Mathematics, Sociology, and Computer Science common to two universities with differing missions (teaching and service. Findings: The results reveal the bias inherent in relying solely on research as a proxy for overall productivity in institutions that have differing missions. Recommendations for Practitioners: Utilizing better metrics informs higher education administrators, promotes better decision-making, and allows incentives to re-align with desired outcomes. Recommendation for Researchers: This paper recommends combing all aspects of faculty workload into a single benchmark index to better measure departmental productivity. Future Research: Further research into improving this simple index is warranted and would include how to account for quality and other facets of productivity.

  9. On the societal nature of praxis and organic research

    Science.gov (United States)

    Roth, Wolff-Michael

    2016-03-01

    In its focus on social practices, the feature article presents an interesting theoretical framework for rethinking not only where and how knowing and learning in science education exhibit themselves but also we might change our own research practice. The framework is not new to me, as I have advocated it explicitly for more than 15 years. But over time it became apparent to me that some particularities of participation in practice may be grounded more strongly in an orientation towards the societal nature of any human praxis. In this forum contribution, I present a theoretical approach built on societal-historical activity theory that also takes activism as a major category for theorizing participation. This approach not only covers the extent of the social practice framework but also allows us to make thematic the production of inequity and restrictions to access science and engineering that are characteristic of many societies.

  10. Does species diversity limit productivity in natural grassland communities?

    NARCIS (Netherlands)

    Grace, James B.; Anderson, T. Michael; Smith, Melinda D.; Seabloom, Eric; Andelman, Sandy J.; Meche, Gayna; Weiher, Evan; Allain, Larry K.; Jutila, Heli; Sankaran, Mahesh; Knops, Johannes; Ritchie, Mark; Willig, Michael R.

    Theoretical analyses and experimental studies of synthesized assemblages indicate that under particular circumstances species diversity can enhance community productivity through niche complementarity. It remains unclear whether this process has important effects in mature natural ecosystems where

  11. Animal Production Research Advances: Editorial Policies

    African Journals Online (AJOL)

    Focus and Scope. Animal production research advances is a peer-review journal established expressly to promote the production of all animal species utilized as food. The journal has an international scope and is intended for professionals in animal production and related sciences. We solicit contributions from animal ...

  12. Natural products in soil microbe interactions and evolution.

    Science.gov (United States)

    Traxler, Matthew F; Kolter, Roberto

    2015-07-01

    In recent years, bacterial interspecies interactions mediated by small molecule natural products have been found to give rise to a surprising array of phenotypes in soil-dwelling bacteria, especially among Streptomyces and Bacillus species. This review examines these interspecies interactions, and the natural products involved, as they have been presented in literature stemming from four disciplines: soil science, interspecies microbiology, ecology, and evolutionary biology. We also consider how these interactions fit into accepted paradigms of signaling, cueing, and coercion.

  13. Anti-Enterovirus 71 Agents of Natural Products

    Directory of Open Access Journals (Sweden)

    Liyan Wang

    2015-09-01

    Full Text Available This review, with 42 references, presents the fascinating area of anti-enterovirus 71 natural products over the last three decades for the first time. It covers literature published from 2005–2015 and refers to compounds isolated from biogenic sources. In total, 58 naturally-occurring anti-EV71 compounds are recorded.

  14. Anti-Enterovirus 71 Agents of Natural Products.

    Science.gov (United States)

    Wang, Liyan; Wang, Junfeng; Wang, Lishu; Ma, Shurong; Liu, Yonghong

    2015-09-09

    This review, with 42 references, presents the fascinating area of anti-enterovirus 71 natural products over the last three decades for the first time. It covers literature published from 2005-2015 and refers to compounds isolated from biogenic sources. In total, 58 naturally-occurring anti-EV71 compounds are recorded.

  15. Bioactive activities of natural products against herpesvirus infection.

    Science.gov (United States)

    Son, Myoungki; Lee, Minjung; Sung, Gi-Ho; Lee, Taeho; Shin, Yu Su; Cho, Hyosun; Lieberman, Paul M; Kang, Hyojeung

    2013-10-01

    More than 90% of adults have been infected with at least one human herpesvirus, which establish long-term latent infection for the life of the host. While anti-viral drugs exist that limit herpesvirus replication, many of these are ineffective against latent infection. Moreover, drug-resistant strains of herpesvirus emerge following chemotherapeutic treatment. For example, resistance to acyclovir and related nucleoside analogues can occur when mutations arise in either HSV thymidine kinase or DNA polymerases. Thus, there exists an unmet medical need to develop new anti-herpesvirus agents with different mechanisms of action. In this Review, we discuss the promise of anti-herpetic substances derived from natural products including extracts and pure compounds from potential herbal medicines. One example is Glycyrrhizic acid isolated from licorice that shows promising antiviral activity towards human gammaherpesviruses. Secondly, we discuss anti-herpetic mechanisms utilized by several natural products in molecular level. While nucleoside analogues inhibit replicating herpesviruses in lytic replication, some natural products can disrupt the herpesvirus latent infection in the host cell. In addition, natural products can stimulate immune responses against herpesviral infection. These findings suggest that natural products could be one of the best choices for development of new treatments for latent herpesvirus infection, and may provide synergistic anti-viral activity when supplemented with nucleoside analogues. Therefore, it is important to identify which natural products are more efficacious anti-herpetic agents, and to understand the molecular mechanism in detail for further advance in the anti-viral therapies.

  16. Recent Advances in Substrate-Controlled Asymmetric Cyclization for Natural Product Synthesis

    Directory of Open Access Journals (Sweden)

    Jeyun Jo

    2017-06-01

    Full Text Available Asymmetric synthesis of naturally occurring diverse ring systems is an ongoing and challenging research topic. A large variety of remarkable reactions utilizing chiral substrates, auxiliaries, reagents, and catalysts have been intensively investigated. This review specifically describes recent advances in successful asymmetric cyclization reactions to generate cyclic architectures of various natural products in a substrate-controlled manner.

  17. Research Productivity of Sports Medicine Fellowship Faculty

    OpenAIRE

    Cvetanovich, Gregory L.; Saltzman, Bryan M.; Chalmers, Peter N.; Frank, Rachel M.; Cole, Brian J.; Bach, Bernard R.

    2016-01-01

    Background: Research productivity is considered an important factor in academic advancement in sports medicine. No study to date has evaluated academic productivity and correlates of academic rank for sports medicine fellowship faculty. Purpose: To describe the academic productivity of American Orthopaedic Society for Sports Medicine (AOSSM) fellowship program faculty and to determine the association between academic productivity, fellowship characteristics, and academic rank. Study Design: D...

  18. Emerging trends in the discovery of natural product antibacterials

    DEFF Research Database (Denmark)

    Bologa, Cristian G; Ursu, Oleg; Oprea, Tudor

    2013-01-01

    This article highlights current trends and advances in exploiting natural sources for the deployment of novel and potent anti-infective countermeasures. The key challenge is to therapeutically target bacterial pathogens that exhibit a variety of puzzling and evolutionarily complex resistance...... mechanisms. Special emphasis is given to the strengths, weaknesses, and opportunities in the natural product antibacterial drug discovery arena, and to emerging applications driven by advances in bioinformatics, chemical biology, and synthetic biology in concert with exploiting bacterial phenotypes....... These efforts have identified a critical mass of natural product antibacterial lead compounds and discovery technologies with high probability of successful implementation against emerging bacterial pathogens....

  19. Nature-Inspired Design : Strategies for Sustainable Product Development

    NARCIS (Netherlands)

    De Pauw, I.C.

    2015-01-01

    Product designers can apply different strategies, methods, and tools for sustainable product development. Nature-Inspired Design Strategies (NIDS) offer designers a distinct class of strategies that use ‘nature’ as a guiding source of knowledge and inspiration for addressing sustainability.

  20. The use of natural products for consumption in Denmark

    International Nuclear Information System (INIS)

    Strandberg, M.

    1996-05-01

    Through a questionnaire it was indicated that Danes use products from 'natural' ecosystems in an amount of approximately 2 kg per year. The most used products are berries and meat from game animals, whereas freshwater fish and wild mushrooms are less common in Danish kitchens. (au)

  1. Exploring fungal biodiversity for the production of water-soluble pigments as potential natural food colorants

    DEFF Research Database (Denmark)

    Mapari, Sameer Shamsuddin; Nielsen, Kristian Fog; Larsen, Thomas Ostenfeld

    2005-01-01

    The production of many currently authorized natural food colorants has a number of disadvantages, including a dependence on the supply of raw materials and variations in pigment extraction. Fungi provide a readily available alternative source of naturally derived food colorants that could easily...... be produced in high yields. The recent authorization of a fungal food colorant has fuelled research to explore the extraordinary chemical diversity and biodiversity of fungi for the biotechnological production of pigments as natural food colorants. These studies require an appropriate use of chernotaxonomic...... technology, in the future it should be possible to employ metabolic engineering to create microbial cell factories for the production of food colorants....

  2. World statistics on natural gas reserves, production and utilization

    International Nuclear Information System (INIS)

    Raikaslehto, S.

    2001-01-01

    By reviewing the statistics of BP Amoco on natural gas reserves, production and usage, it is easy to see that Russia and USA, both being large natural gas producers, differ significantly from each other. The natural gas reserves of USA are 6th largest in the world, simultaneously the natural gas consumption and import are largest in the world. About one third of the known natural gas reserves of the world are in Russia. The known natural gas reserves of both USA and Canada have decreases, but they have potential gas reserves left. Known natural gas reserves of the USA have been calculated to be sufficient for 9 years consumption at present usage and those of Canada for 11 years. The reserves of Algeria correspond to the usage of 55 years, and the Russian reserves for are about 83 years. Annual production figures of both Russia and the USA are nearly the same. Russia is the largest exporter (125.5 billion m 3 ) of natural gas and the USA the largest importer (96 billion m 3 ). The natural gas reserves of the largest European producers, the Netherlands and Norway have been estimated to be sufficient for use of about 20 years, but those of Great Britain only for about 10 years. The annual production of Russia has varied in the 1990s between nearly 600 billion m 3 and present 550 billion m 3 , the minimum being in 1997 only about 532 billion m 3 . Ten largest natural gas consumers use 67% of the natural gas consumed annually in the world. USA consumes about 27% of the total natural gas produced in the world, the amount of Russia being 364 billion m 3 (16%). Other large natural gas consumers are Great Britain, Germany, Japan, Ukraine, Canada, Italy, Iran and Uzbekistan. The share of these countries of the total consumption varied in between 2-4%. Only Japan has no natural gas production of its own. The foreign trade between Japan and Indonesia is trade on LNG. On the other hand the natural gas consumption of the world's 10th largest producer Norway is nearly zero, so

  3. Natural product-based nanomedicine: recent advances and issues

    Science.gov (United States)

    Watkins, Rebekah; Wu, Ling; Zhang, Chenming; Davis, Richey M; Xu, Bin

    2015-01-01

    Natural products have been used in medicine for many years. Many top-selling pharmaceuticals are natural compounds or their derivatives. These plant- or microorganism-derived compounds have shown potential as therapeutic agents against cancer, microbial infection, inflammation, and other disease conditions. However, their success in clinical trials has been less impressive, partly due to the compounds’ low bioavailability. The incorporation of nanoparticles into a delivery system for natural products would be a major advance in the efforts to increase their therapeutic effects. Recently, advances have been made showing that nanoparticles can significantly increase the bioavailability of natural products both in vitro and in vivo. Nanotechnology has demonstrated its capability to manipulate particles in order to target specific areas of the body and control the release of drugs. Although there are many benefits to applying nanotechnology for better delivery of natural products, it is not without issues. Drug targeting remains a challenge and potential nanoparticle toxicity needs to be further investigated, especially if these systems are to be used to treat chronic human diseases. This review aims to summarize recent progress in several key areas relevant to natural products in nanoparticle delivery systems for biomedical applications. PMID:26451111

  4. [Out of natural order: nature in discourses about cloning and stem cell research in Brazilian newspapers].

    Science.gov (United States)

    Medeiros, Flavia Natércia da Silva

    2013-11-30

    Different conceptions of nature influence media coverage and public opinion about biotechnology. This study reports on a discourse analysis of the ideas about nature and what is natural expressed in Brazilian media coverage of cloning and stem cell research. In the discourse against this research, the biotechnologies in question are placed outside the natural order of things and deemed immoral. In the discourse of those who defend it, nature is portrayed as indifferent to the fate of humans or even cruel, or else a barrier to be overcome, while cloning and embryonic stem cells are naturalized and Dolly the sheep is anthropomorphized. The mythifying or transcendental representations of nature do not just influence public opinion, but also have ethical and political implications.

  5. Bioengineering natural product biosynthetic pathways for therapeutic applications.

    Science.gov (United States)

    Wu, Ming-Cheng; Law, Brian; Wilkinson, Barrie; Micklefield, Jason

    2012-12-01

    With the advent of next-generation DNA sequencing technologies, the number of microbial genome sequences has increased dramatically, revealing a vast array of new biosynthetic gene clusters. Genomics data provide a tremendous opportunity to discover new natural products, and also to guide the bioengineering of new and existing natural product scaffolds for therapeutic applications. Notably, it is apparent that the vast majority of biosynthetic gene clusters are either silent or produce very low quantities of the corresponding natural products. It is imperative therefore to devise methods for activating unproductive biosynthetic pathways to provide the quantities of natural products needed for further development. Moreover, on the basis of our expanding mechanistic and structural knowledge of biosynthetic assembly-line enzymes, new strategies for re-programming biosynthetic pathways have emerged, resulting in focused libraries of modified products with potentially improved biological properties. In this review we will focus on the latest bioengineering approaches that have been utilised to optimise yields and increase the structural diversity of natural product scaffolds for future clinical applications. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. Marketing research of organic agricultural products' customers

    Directory of Open Access Journals (Sweden)

    Salai Suzana

    2002-01-01

    Full Text Available The aim of customers' marketing research is to acquire information about the way domestic customers behave towards organic agricultural products. This research focuses the overview of conditions and factors influencing customer behavior in nutrition processes in the EM and in Yugoslavia. The acquired information about changes and directions directly affect the possibilities of getting involved into supply processes as well as the 'transmission' of some directions in customer behavior. Anticipations based, on marketing research deal with changes on customers' level, in consumption, products and other competitors. The results of a part of problems concerning customer behavior in nutrition processes follow below, with an emphasis on organic agricultural products.

  7. Research and development for ethylbenzene production

    Energy Technology Data Exchange (ETDEWEB)

    Xue, Mingwei; Sun, Hongmin; Shen, Zhenhao; Zhang, Bin; Yang, Weimin [SINOPEC Shanghai Research Institute of Petrochemical Technology (China); Huan, Mingyao

    2013-11-01

    Ethylbenzene (EB) is important raw material for the production of styrene. Now, EB is mainly produced by the alkylation of benzene with ethylene catalyzed by zeolite in vapour phase or liquid phase. Shanghai Research Institute of Petrochemical Technology (SRIPT) began to research the catalysts for the production of ethylbenezene in 1993. With near 20 years work, three series of catalysts for the alkylation of benzene with pure ethylene, dilute ethylene and ethanol are in commerical in China. This paper mainly introduced the research and development of SRIPT for the EB production. (orig.)

  8. Benchmarking of Processes for the Biosynthesis of Natural Products

    DEFF Research Database (Denmark)

    Seita, Catarina Sanches

    putida GS1. (R)-perillic acid is a monoterpenoic acid with antimicrobial properties. It has a strong inhibitory effect on bacteria and fungus, which makes it an attractive compound to be used as a preservative for instance in cosmetic industry, but on the other hand makes the biosynthesis a complicated....... These biological activities can be of interest for use in different sectors of chemical industry, in particular pharmaceutical industry where several drugs are derived or inspired by natural products structure. However, the large scale production of natural products is hindered by its relatively poor abundance...... of the process in comparison with other sweeteners. The main benefit of this early-stage evaluation is putting the biosynthesis of natural products into context in relation to demands of an industrially feasible chemical process. Moreover, it can give very meaningful insight into process development and provides...

  9. Transitions in Sustainable Product Design Research

    DEFF Research Database (Denmark)

    Boks, Casper; McAloone, Tim C.

    2009-01-01

    By the early 1990s, sustainable product innovation (or ecodesign, or Design for environment) had gained sufficient critical mass in academic research to be identified as a distinct research area. In the past 15 years, stimulated by a growing environmental concern and awareness in the media...... of transitions; this is illustrated by discussing characteristic aspects of each transition, which together provide a historic account of how academic research into sustainable product innovation had matured. In conclusion, a number of possible future transitions or extensions of the research area are discussed......., this research area has expanded considerably; from a bunch of opportunistic eco-pathfinders trying to make products better recyclable into acknowledged scientific research regarding technology transfer and commercialisation. This paper proposes that this maturing process took place through a number...

  10. A Growing Disconnection From Nature Is Evident in Cultural Products.

    Science.gov (United States)

    Kesebir, Selin; Kesebir, Pelin

    2017-03-01

    Human connection with nature is widely believed to be in decline even though empirical evidence is scarce on the magnitude and historical pattern of the change. Studying works of popular culture in English throughout the 20th century and later, we have documented a cultural shift away from nature that begins in the 1950s. Since then, references to nature have been decreasing steadily in fiction books, song lyrics, and film storylines, whereas references to the human-made environment have not. The observed temporal pattern is consistent with the explanatory role of increased virtual and indoors recreation options (e.g., television, video games) in the disconnect from nature, and it is inconsistent with a pure urbanization account. These findings are cause for concern, not only because they imply foregone physical and psychological benefits from engagement with nature, but also because cultural products are agents of socialization that can evoke curiosity, respect, and concern for the natural world.

  11. Deposits of naturally occurring radioactivity in production of oil and natural gas

    International Nuclear Information System (INIS)

    Strand, T.; Lysebo, I.; Kristensen, D.; Birovljev, A.

    1997-01-01

    Deposits of naturally occurring radioactive materials is an increasing problem in Norwegian oil and gas production. Activity concentration in solid-state samples and production water, and doses to workers involved in different operations off-shore, have been measured. The report also includes a discussion of different methods of monitoring and alternatives for final disposal of wastes. 154 refs

  12. Planning of optimum production from a natural gas field

    Energy Technology Data Exchange (ETDEWEB)

    Van Dam, J

    1968-03-01

    The design of an optimum development plan for a natural gas field always depends on the typical characteristics of the producing field, as well as those of the market to be served by this field. Therefore, a good knowledge of the field parameters, such as the total natural gas reserves, the well productivity, and the dependence of production rates on pipeline pressure and depletion of natural gas reserves, is required prior to designing the development scheme of the field, which in fact depends on the gas-sales contract to be concluded in order to commit the natural gas reserves to the market. In this paper these various technical parameters are discussed in some detail, and on this basis a theoretical/economical analysis of natural gas production is given. For this purpose a simplified economical/mathematical model for the field is proposed, from which optimum production rates at various future dates can be calculated. The results of these calculations are represented in a dimensionless diagram which may serve as an aid in designing optimum development plans for a natural gas field. The use of these graphs is illustrated in a few examples.

  13. Natural product-based nanomedicine: recent advances and issues

    Directory of Open Access Journals (Sweden)

    Watkins R

    2015-09-01

    Full Text Available Rebekah Watkins,1,2,* Ling Wu,1,* Chenming Zhang,3–5 Richey M Davis,3,5,6 Bin Xu1,3 1Department of Biochemistry, 2Program in Nanoscience, 3Center for Drug Discovery, 4Department of Biological Systems Engineering, 5Institute for Critical Technology and Applied Science, 6Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA *These authors contributed equally to this work Abstract: Natural products have been used in medicine for many years. Many top-selling pharmaceuticals are natural compounds or their derivatives. These plant- or microorganism-derived compounds have shown potential as therapeutic agents against cancer, microbial infection, inflammation, and other disease conditions. However, their success in clinical trials has been less impressive, partly due to the compounds’ low bioavailability. The incorporation of nanoparticles into a delivery system for natural products would be a major advance in the efforts to increase their therapeutic effects. Recently, advances have been made showing that nanoparticles can significantly increase the bioavailability of natural products both in vitro and in vivo. Nanotechnology has demonstrated its capability to manipulate particles in order to target specific areas of the body and control the release of drugs. Although there are many benefits to applying nanotechnology for better delivery of natural products, it is not without issues. Drug targeting remains a challenge and potential nanoparticle toxicity needs to be further investigated, especially if these systems are to be used to treat chronic human diseases. This review aims to summarize recent progress in several key areas relevant to natural products in nanoparticle delivery systems for biomedical applications. Keywords: natural products, nanomedicine, drug delivery, bioavailability, targeting, controlled release

  14. U.S. Nuclear Regulatory Commission natural analogue research program

    International Nuclear Information System (INIS)

    Kovach, L.A.; Ott, W.R.

    1995-01-01

    This article describes the natural analogue research program of the U.S. Nuclear Regulatory Commission (US NRC). It contains information on the regulatory context and organizational structure of the high-level radioactive waste research program plan. It also includes information on the conditions and processes constraining selection of natural analogues, describes initiatives of the US NRC, and describes the role of analogues in the licensing process

  15. Culture-independent discovery of natural products from soil metagenomes.

    Science.gov (United States)

    Katz, Micah; Hover, Bradley M; Brady, Sean F

    2016-03-01

    Bacterial natural products have proven to be invaluable starting points in the development of many currently used therapeutic agents. Unfortunately, traditional culture-based methods for natural product discovery have been deemphasized by pharmaceutical companies due in large part to high rediscovery rates. Culture-independent, or "metagenomic," methods, which rely on the heterologous expression of DNA extracted directly from environmental samples (eDNA), have the potential to provide access to metabolites encoded by a large fraction of the earth's microbial biosynthetic diversity. As soil is both ubiquitous and rich in bacterial diversity, it is an appealing starting point for culture-independent natural product discovery efforts. This review provides an overview of the history of soil metagenome-driven natural product discovery studies and elaborates on the recent development of new tools for sequence-based, high-throughput profiling of environmental samples used in discovering novel natural product biosynthetic gene clusters. We conclude with several examples of these new tools being employed to facilitate the recovery of novel secondary metabolite encoding gene clusters from soil metagenomes and the subsequent heterologous expression of these clusters to produce bioactive small molecules.

  16. Biotransformation and Production from Hansenula Anomala to Natural Ethyl Phenylacetate

    Directory of Open Access Journals (Sweden)

    Tian Xun

    2015-01-01

    Full Text Available Ethyl phenylacetate can be widely applied in many industries, such as food, medicines, cosmetics and medicinal herbs. At the moment, the production of natural ethyl phenylacetate is very limited. However, the biotransformation production of natural ethyl phenylacetate has an very extensive application prospect. This paper is written by taking the phenylacetic acid tolerance and the esterifying enzyme activity as the two indexes for screening the HA14 strain of hansenula anomala mutagenic which is regarded as the microorganism of ethyl phenylacetate production through biotransformation. By optimizing the production condition of phenylacetic acid and the esterification condition of ethyl phenylacetate, the production of ethyl phenylacetate accomplished through biotransformation within 72 hours can reach 864mg/L which is 171% of that of the initial bacterial strain.

  17. Wood products research in the USA

    Science.gov (United States)

    Theodore Wegner

    2010-01-01

    Forest biomass conversion to biofuels and other value-added co-products; hyper-performance advanced composites custom tailored to end use requirements; advanced high performance wood-based structures; and nanomaterials and nano-enable high performance products from wood represent important research and development investment areas for the successful transformation of...

  18. Time management strategies for research productivity.

    Science.gov (United States)

    Chase, Jo-Ana D; Topp, Robert; Smith, Carol E; Cohen, Marlene Z; Fahrenwald, Nancy; Zerwic, Julie J; Benefield, Lazelle E; Anderson, Cindy M; Conn, Vicki S

    2013-02-01

    Researchers function in a complex environment and carry multiple role responsibilities. This environment is prone to various distractions that can derail productivity and decrease efficiency. Effective time management allows researchers to maintain focus on their work, contributing to research productivity. Thus, improving time management skills is essential to developing and sustaining a successful program of research. This article presents time management strategies addressing behaviors surrounding time assessment, planning, and monitoring. Herein, the Western Journal of Nursing Research editorial board recommends strategies to enhance time management, including setting realistic goals, prioritizing, and optimizing planning. Involving a team, problem-solving barriers, and early management of potential distractions can facilitate maintaining focus on a research program. Continually evaluating the effectiveness of time management strategies allows researchers to identify areas of improvement and recognize progress.

  19. Process-Product Research: A Cornerstone in Educational Effectiveness Research

    Science.gov (United States)

    Creemers, Bert; Kyriakides, Leonidas

    2015-01-01

    This article links the contribution of process-product studies in developing the theoretical framework of educational effectiveness by pointing out the importance of teacher behavior in the classroom. The role that Jere Brophy played in this evolving research is described within the various phases of teacher effectiveness research. Process-product…

  20. Impact of research investment on scientific productivity of junior researchers.

    Science.gov (United States)

    Farrokhyar, Forough; Bianco, Daniela; Dao, Dyda; Ghert, Michelle; Andruszkiewicz, Nicole; Sussman, Jonathan; Ginsberg, Jeffrey S

    2016-12-01

    There is a demand for providing evidence on the effectiveness of research investments on the promotion of novice researchers' scientific productivity and production of research with new initiatives and innovations. We used a mixed method approach to evaluate the funding effect of the New Investigator Fund (NIF) by comparing scientific productivity between award recipients and non-recipients. We reviewed NIF grant applications submitted from 2004 to 2013. Scientific productivity was assessed by confirming the publication of the NIF-submitted application. Online databases were searched, independently and in duplicate, to locate the publications. Applicants' perceptions and experiences were collected through a short survey and categorized into specified themes. Multivariable logistic regression was performed. Odds ratios (OR) with 95 % confidence intervals (CI) are reported. Of 296 applicants, 163 (55 %) were awarded. Gender, affiliation, and field of expertise did not affect funding decisions. More physicians with graduate education (32.0 %) and applicants with a doctorate degree (21.5 %) were awarded than applicants without postgraduate education (9.8 %). Basic science research (28.8 %), randomized controlled trials (24.5 %), and feasibility/pilot trials (13.3 %) were awarded more than observational designs (p   scientific productivity and professional growth of novice investigators and production of research with new initiatives and innovations. Further efforts are recommended to enhance the support of small grant funding programs.

  1. The use of radiotracers in natural rubber research in Malaysia

    International Nuclear Information System (INIS)

    Lai, P.F.; Singh, M.M.

    1981-01-01

    Five main areas where radiotracers have been used in research on natural rubber are on studies on the uptake of plant nutrients by Hevea brasiliensis using 32 P, 86 Rb and 45 Ca as tracers; biosynthesis of Hevea rubber using 14 C or 3 H labelled intermediates; translocation and metabolism of 14 C. Ethephon in Hevea brasiliensis; use of radiotracers as analytical tools and adsorption of labelled fatty acid soaps on natural rubber lattices. These studies are discussed to show the powerful tool that radiotracers provide in agricultural, biochemical and chemical research on natural rubber. (author)

  2. World natural gas supply and demand: Brief pause in production

    International Nuclear Information System (INIS)

    Coccia, G.

    1993-01-01

    With reference to the 1992 CEDIGAZ (Centre International sur le Gas Naturel et tous Hydrocarbures Gazeux) report on world natural gas supply and demand, this paper assesses current market and production trends in this industry. The slight drop in production in 1992, the first which has which has occurred after many consecutive years of steady increases, is ascribed to ownership disputes among the former-USSR republics and major changes in the organizational structure of the former-USSR's natural gas industry. Strong increases in demand are forecasted due to expected strong population growth and increased industrialization to take place in China and India. Price trends in natural gas should remain steady as a result of plentiful supplies of this fuel and coal, a major competitor. The use of relatively clean natural gas is suggested as a practical alternative to energy taxes now being proposed as a means for the reduction of greenhouse gas emissions

  3. Radon gas in oil and natural gas production facilities

    International Nuclear Information System (INIS)

    Chandler, W.P.

    1994-01-01

    Radon gas is a naturally occurring radionuclide that can be found in some oil and natural gas production facilities, either as a contaminant in a natural gas stream or derived from Radium dissolved in formation waters. The gas itself is not normally a health hazard, but it's decay products, which can be concentrated by plate-out or deposition as a scale in process equipment, can be a health hazard for maintenance personnel. To evaluate possible health hazards, it is necessary to monitor for naturally occurring radioactive materials (NORM) in the gas stream and in the formation water. If Radon and/or Radium is found, a monitoring programme should be initiated to comply with National or State requirements. In some instances, it has been found necessary to dispose of silt and scale materials as low level radioactive waste. 8 refs

  4. Bioactive natural products from Chinese marine flora and fauna.

    Science.gov (United States)

    Zhou, Zhen-Fang; Guo, Yue-Wei

    2012-09-01

    In recent decades, the pharmaceutical application potential of marine natural products has attracted much interest from both natural product chemists and pharmacologists. Our group has long been engaged in the search for bioactive natural products from Chinese marine flora (such as mangroves and algae) and fauna (including sponges, soft corals, and mollusks), resulting in the isolation and characterization of numerous novel secondary metabolites spanning a wide range of structural classes and various biosynthetic origins. Of particular interest is the fact that many of these compounds show promising biological activities, including cytotoxic, antibacterial, and enzyme inhibitory effects. By describing representative studies, this review presents a comprehensive summary regarding the achievements and progress made by our group in the past decade. Several interesting examples are discussed in detail.

  5. Dereplication of Microbial Natural Products by LC-DAD-TOFMS

    DEFF Research Database (Denmark)

    Nielsen, Kristian Fog; Månsson, Maria; Rank, Christian

    2011-01-01

    Dereplication, the rapid identification of known compounds present in a mixture, is crucial to the fast discovery of novel natural products. Determining the elemental composition of compounds in mixtures and tentatively identifying natural products using MS/MS and UV/vis spectra is becoming easier...... with advances in analytical equipment and better compound databases. Here we demonstrate the use of LC-UV/vis-MS-based dereplication using data from UV/vis diode array detection and ESI+/ESI– time-of-flight MS for assignment of 719 microbial natural product and mycotoxin reference standards. ESI+ was the most...... unambiguously using multiple adduct ions, while a further 41% of the compounds were detected only as [M – H]−. The most reliable interpretations of conflicting ESI+ and ESI– data on a chromatographic peak were from the ionization polarity with the most intense ionization. Poor ionization was most common...

  6. Natural radionuclide distribution in phosphate fertilizer and superphosphate production technology

    Energy Technology Data Exchange (ETDEWEB)

    Lisachenko, Eh P; Ponikarova, T M; Lisitsyna, Yu Z

    1987-01-01

    The obtained data on the natural radionuclide distribution by phosphate fertilizer and superphosphate production process stages testify to phosphate fertilizer enrichment 2-4 times in relation to initial ore, depending in the raw material used. In this case uranium and thorium series element concentration value (in equilibrium with their decomposition products), proposed as a regulating one in phosphorus-containing fertilizers, is not achieved. However, the fact of lurichment as it is and the enrichment factor, stated in the course of the work, should be taken into account for evaluation of phosphorite new deposit raw material with higher concentrations of natural radionuclides. Natural radionuclide separation in the enrichment process and superphosphate production is not revealed.

  7. α-Haloaldehydes: versatile building blocks for natural product synthesis.

    Science.gov (United States)

    Britton, Robert; Kang, Baldip

    2013-02-01

    The diastereoselective addition of organometallic reagents to α-chloroaldehydes was first reported in 1959 and occupies a historically significant role as the prototypical reaction for Cornforth's model of stereoinduction. Despite clear synthetic potential for these reagents, difficulties associated with producing enantiomerically enriched α-haloaldehydes limited their use in natural product synthesis through the latter half of the 20th century. In recent years, however, a variety of robust, organocatalytic processes have been reported that now provide direct access to optically enriched α-haloaldehydes and have motivated renewed interest in their use as building blocks for natural product synthesis. This Highlight summarizes the methods available for the enantioselective preparation of α-haloaldehydes and their stereoselective conversion into natural products.

  8. Search for bioactive natural products from medicinal plants of Bangladesh.

    Science.gov (United States)

    Ahmed, Firoj; Sadhu, Samir Kumar; Ishibashi, Masami

    2010-10-01

    In our continuous search for bioactive natural products from natural resources, we explored medicinal plants of Bangladesh, targeting cancer-related tumor necrosis factor-related apoptosis-inducing ligand-signaling pathway, along with some other biological activities such as prostaglandin inhibitory activity, 1,1-diphenyl-2-picrylhydrazyl free-radical-scavenging activity, and cell growth inhibitory activity. Along with this, we describe a short field study on Sundarbans mangrove forests, Bangladesh, in the review.

  9. Knowledge based decision making: perspective on natural gas production

    Energy Technology Data Exchange (ETDEWEB)

    Ydstie, B. Erik; Stuland, Kjetil M.

    2009-07-01

    Conclusions (drawn by the author): Decarbonization of energy sources - From coal to renewable. Natural Gas Abundantly available - Norway is no. 3 exporter. Natural gas important as - Hydrogen source for chemicals; - Electricity; - End consumer usage (heating etc). Large potential for application of model based decision making; - Where and when to install platforms and drill wells - How to operate platforms and pipeline systems; - How to operate and optimize chemical production; - Optimization of electricity generation systems. (author)

  10. Biomass production and basic research on photosynthesis

    International Nuclear Information System (INIS)

    Broda, E.

    1979-01-01

    This document is a report of the conference: research and development work in Austria, organized by Austrian ministry of science and research, the ASSA and the OMV-stock company in 1979, which took place in Vienna. The text is about the different possible forms of solar energy utilization. Broda analyses in detail the utilization and production of biomass. (nowak)

  11. Research Productivity: Some Paths Less Travelled

    Science.gov (United States)

    Martin, Brian

    2009-01-01

    Conventional approaches for fostering research productivity, such as recruitment and incentives, do relatively little to develop latent capacities in researchers. Six promising unorthodox approaches are the promotion of regular writing, tools for creativity, good luck, happiness, good health and crowd wisdom. These options challenge conventional…

  12. Exposures from consumption of agricultural and semi-natural products

    International Nuclear Information System (INIS)

    Strand, P.; Skuterud, L.; Balonov, M.; Travnikova, I.; Hove, K.; Howard, B.; Prister, B.S.; Ratnikov, A.

    1996-01-01

    The importance of food from different production systems to the internal dose from radiocesium, was investigated in selected study sites in Ukraine and Russia. Food products from semi-natural ecosystems are major contributors to the individual internal dose to rural population in areas affected by the Chernobyl accident. At the selected study sites it is estimated in 1995 that foods from private farms and forests contribute on average 35% to 60%, to the individual internal dose, variation relating to soil types and implemented countermeasures. The importance of food products from private farms and particularly forest products increases with time since Cs concentration in some of the natural food products have longer ecological half life than food products from agricultural systems. A significant relationship was observed between consumption of mushrooms and whole body content of radiocesium in rural people. The contribution to the collective dose of food products produced in the semi-natural ecosystems is less than the contribution to the individual internal dose for the local rural population

  13. LC-NMR: profiling and dereplication of natural product extracts

    International Nuclear Information System (INIS)

    Urban, Sylvia

    2006-01-01

    Natural products have served as a major source of drugs for centuries, with over half of the pharmaceuticals in use today derived from natural origins. Natural products continue to play a dominant role in the discovery of leads for the development of drugs for the treatment of human diseases. Much remains to be explored, particularly the marine and microbial environments, from which a host of novel bioactive chemical entities await discovery. The search for new drugs from natural origins (either terrestrial or marine) involves screening of extracts for the presence of novel compounds and an investigation of their biological activities. Suspected novel or bioactive compounds are usually isolated to elucidate the structure and for further biological and toxicological testing. The path that leads from the intact terrestrial or marine organism to the pure constituents is long, involving work that might last from weeks to years. Recognition of natural products at the earliest possible stage of separation is known as dereplication and is essential to avoid the time-consuming isolation of common constituents and nuisance compounds. In the search for new natural products, crude extracts are typically subjected to multi-step work-up and isolation procedures, which include various separation methods, in order to obtain pure compounds whose structure is then elucidated using off-line spectroscopic methods such as nuclear magnetic resonance (NMR) and mass spectroscopy (MS). The characterisation of a natural product can be summarised by the information obtained from each of the individual spectroscopic techniques. With the application of one or more of these individual techniques a dereplication by partial characterisation is possible. As natural product extracts often contain a large number of closely related, and thus difficult to separate, compounds, this classical approach may become very tedious and time-consuming. The characterisation of natural products in complex

  14. Marine actinobacteria: an important source of bioactive natural products.

    Science.gov (United States)

    Manivasagan, Panchanathan; Kang, Kyong-Hwa; Sivakumar, Kannan; Li-Chan, Eunice C Y; Oh, Hyun-Myung; Kim, Se-Kwon

    2014-07-01

    Marine environment is largely an untapped source for deriving actinobacteria, having potential to produce novel, bioactive natural products. Actinobacteria are the prolific producers of pharmaceutically active secondary metabolites, accounting for about 70% of the naturally derived compounds that are currently in clinical use. Among the various actinobacterial genera, Actinomadura, Actinoplanes, Amycolatopsis, Marinispora, Micromonospora, Nocardiopsis, Saccharopolyspora, Salinispora, Streptomyces and Verrucosispora are the major potential producers of commercially important bioactive natural products. In this respect, Streptomyces ranks first with a large number of bioactive natural products. Marine actinobacteria are unique enhancing quite different biological properties including antimicrobial, anticancer, antiviral, insecticidal and enzyme inhibitory activities. They have attracted global in the last ten years for their ability to produce pharmaceutically active compounds. In this review, we have focused attention on the bioactive natural products isolated from marine actinobacteria, possessing unique chemical structures that may form the basis for synthesis of novel drugs that could be used to combat resistant pathogenic microorganisms. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. Natural product terpenoids in Eocene and Miocene conifer fossils.

    Science.gov (United States)

    Otto, Angelika; White, James D; Simoneit, Bernd R T

    2002-08-30

    Numerous saturated and aromatic hydrocarbons, but not polar compounds, originating from plants and microorganisms (biomarkers) have been reported in sediments, coals, and petroleum. Here we describe natural product terpenoids found in two fossil conifers, Taxodium balticum (Eocene) and Glyptostrobus oregonensis (Miocene). A similar terpenoid pattern is also observed in extant Taxodium distichum. The preservation of characteristic terpenoids (unaltered natural products) in the fossil conifers supports their systematic assignment to the Cypress family (Cupressaceae sensu lato). The results also show that fossil conifers can contain polar terpenoids, which are valuable markers for (paleo)chemosystematics and phylogeny.

  16. Synthesis and Biological Investigation of Antioxidant Pyrrolomorpholine Spiroketal Natural Products

    Science.gov (United States)

    Verano, Alyssa Leigh

    The pyrrolomorpholine spiroketal natural product family is comprised of epimeric furanose and pyranose isomers. These compounds were isolated from diverse plant species, all of which are used as traditional Chinese medicines for the treatment of a variety of diseases. Notably, the spiroketal natural products acortatarins A and B exhibit antioxidant activity in a diabetic renal cell model, significantly attenuating hyperglycemia-induced production of reactive oxygen species (ROS), a hallmark of diabetic nephropathy. The xylapyrrosides, additional members of the family, also inhibit t-butyl hydroperoxide-induced cytotoxicity in rat vascular smooth muscle cells. Accordingly, these natural products have therapeutic potential for the treatment of oxidative stress-related pathologies, and synthetic access would provide an exciting opportunity to investigate bioactivity and mechanism of action. Herein, we report the stereoselective synthesis of acortatarins A and B, furanose members of the pyrrolomorpholine spiroketal family. Our synthetic route was expanded to synthesize the pyranose congeners, thus completing entire D-enantiomeric family of natural products. Efficient access towards these scaffolds enabled systematic analogue synthesis, investigation of mechanism-of-action, and the discovery of novel antioxidants.

  17. The nature of qualitative construction partnering research : literature review

    NARCIS (Netherlands)

    Marieke Venselaar; Hans Warmelink

    2017-01-01

    from the publisher's site: "The purpose of this paper is to investigate the nature of qualitative construction partnering research. Design/methodology/approach. In total, 20 qualitative peer-reviewed papers about construction partnering research are reviewed. Findings: The results show four

  18. Natural fibers for hydrogels production and their applications in agriculture

    Directory of Open Access Journals (Sweden)

    Liliana Serna Cock

    2017-10-01

    Full Text Available This paper presents a review on hydrogels applied to agriculture emphasizing on the use of natural fibers. The objectives were to examine, trends in research addressed to identify natural fibers used in hydrogels development and methods for modifying natural fibers, understand factors which determine the water retention capacity of a hydrogel. Consequently, this paper shows some methodologies used to evaluate the hydrogels efficiency and to collect in tables, relevant information in relation to methods of natural fibers modification and hydrogel synthesis. It was found that previous research focused on hydrogels development processed with biodegradable polymers such as starch, chitosan and modified natural fibers, cross-linked with potassium acrylate and acrylamide, respectively. In addition, current researches aimed to obtaining hydrogels with improved properties, which have allowed a resistance to climatic variations and soil physicochemical changes, such as pH, presence of salts, temperature and composition. In fact, natural fibers such as sugarcane, agave fiber and kapok fiber, modified with maleic anhydride, are an alternative to obtain hydrogels due to an increasing of mechanical properties and chemically active sites. However, the use of natural nanofibers in hydrogels, has been a successful proposal to improve hydrogels mechanical and swelling properties, since they give to material an elasticity and rigidity properties. A hydrogel efficiency applied to soil, is measured throughout properties as swellability, mechanical strength, and soil water retention. It was concluded that hydrogels, are an alternative to the current needs for the agricultural sector.

  19. European energy security: The future of Norwegian natural gas production

    International Nuclear Information System (INIS)

    Soederbergh, Bengt; Jakobsson, Kristofer; Aleklett, Kjell

    2009-01-01

    The European Union (EU) is expected to meet its future growing demand for natural gas by increased imports. In 2006, Norway had a 21% share of EU gas imports. The Norwegian government has communicated that Norwegian gas production will increase by 25-40% from today's level of about 99 billion cubic meters (bcm)/year. This article shows that only a 20-25% growth of Norwegian gas production is possible due to production from currently existing recoverable reserves and contingent resources. A high and a low production forecast for Norwegian gas production is presented. Norwegian gas production exported by pipeline peaks between 2015 and 2016, with minimum peak production in 2015 at 118 bcm/year and maximum peak production at 127 bcm/year in 2016. By 2030 the pipeline export levels are 94-78 bcm. Total Norwegian gas production peaks between 2015 and 2020, with peak production at 124-135 bcm/year. By 2030 the production is 96-115 bcm/year. The results show that there is a limited potential for increased gas exports from Norway to the EU and that Norwegian gas production is declining by 2030 in all scenarios. Annual Norwegian pipeline gas exports to the EU, by 2030, may even be 20 bcm lower than today's level.

  20. Experimental Researches Regarding the Ecological Dyeing with Natural Extracts

    Directory of Open Access Journals (Sweden)

    Budeanu Ramona

    2014-12-01

    Full Text Available The concept of ‘environmental awareness’ has recently had a major impact on the textile industry and on the fashion world as well. In this context, the use of natural fibres and the development of natural dyeing processes gradually became important goals of the textile industry. Of all natural textile fibres, hemp is considered to be one of the strongest and most durable. A wide range of natural extracts have been used for natural textile coloration and dyeing. Dyes deriving from natural sources have emerged as an important alternative to synthetic dyes. Ecofriendly, nontoxic, sustainable and renewable natural dyes and pigments have been used for colouring the food substrate, leather, wood, natural fibres and fabrics from the dawn of human history. The purpose of the research is to obtain ecologically coloured fabrics for textiles by using a method of dyeing that relies on natural ingredients extracted from red beet, onion leaves and black tea. The experiments are conducted on three different types of hemp fabrics. This paper presents the results of the studies regarding the dyeing process of hemp fabrics with natural extracts, the colours of the dyed samples inspected with reflectance spectra and the CIE L*a*b* colour space measurements.

  1. An innovative model for regulating supplement products: Natural health products in Canada

    International Nuclear Information System (INIS)

    Nestmann, Earle R.; Harwood, Melody; Martyres, Stephanie

    2006-01-01

    On 1 January 2004, Health Canada officially added a new term to the global list of synonyms for dietary supplements: natural health products (NHP). Developed with the intent of providing Canadian consumers with ready access to NHP that are safe, effective, and of high quality, the Natural Health Products Regulations (the NHP regulations) are applicable to the sale, manufacture, packaging, labelling, importation, distribution, and storage of NHP, and are administered by the recently formed Natural Health Products Directorate (NHPD) within Health Canada. This paper provides an overview of the process for regulating supplement products in Canada

  2. Applying environmental product design to biomedical products research.

    Science.gov (United States)

    Messelbeck, J; Sutherland, L

    2000-12-01

    The principal themes for the Biomedical Research and the Environment Conference Committee on Environmental Economics in Biomedical Research include the following: healthcare delivery companies and biomedical research organizations, both nonprofit and for-profit, need to improve their environmental performance; suppliers of healthcare products will be called upon to support this need; and improving the environmental profile of healthcare products begins in research and development (R&D). The committee report begins with requirements from regulatory authorities (e.g., U.S. Environmental Protection Agency [EPA], the U.S. Food and Drug Administration), and the healthcare delivery sector). The 1998 American Hospital Association and EPA Memorandum of Understanding to reduce solid waste and mercury from healthcare facilities is emblematic of these requirements. The dominant message from the requirements discussion is to ensure that R&D organizations do not ignore customer, environmental, and regulatory requirements in the early stages of product development. Several representatives from healthcare products manufacturers presented their companies' approaches to meeting these requirements. They reported on efforts to ensure that their R&D processes are sensitive to the environmental consequences from manufacturing, distributing, using, and disposing of healthcare products. These reports describe representatives' awareness of requirements and the unique approaches their R&D organizations have taken to meet these requirements. All representatives reported that their R&D organizations have embraced environmental product design because it avoids the potential of returning products to R&D to improve the environmental profile. Additionally, several reports detailed cost savings, sustainability benefits, and improvements in environmental manufacturing or redesign, and increased customer satisfaction. Many companies in healthcare delivery are working to improve environmental

  3. Natural Products for the Treatment of Chlamydiaceae Infections

    Directory of Open Access Journals (Sweden)

    Mika A. Brown

    2016-10-01

    Full Text Available Due to the global prevalence of Chlamydiae, exploring studies of diverse antichlamydial compounds is important in the development of effective treatment strategies and global infectious disease management. Chlamydiaceae is the most widely known bacterial family of the Chlamydiae order. Among the species in the family Chlamydiaceae, Chlamydia trachomatis and Chlamydia pneumoniae cause common human diseases, while Chlamydia abortus, Chlamydia psittaci, and Chlamydia suis represent zoonotic threats or are endemic in human food sources. Although chlamydial infections are currently manageable in human populations, chlamydial infections in livestock are endemic and there is significant difficulty achieving effective treatment. To combat the spread of Chlamydiaceae in humans and other hosts, improved methods for treatment and prevention of infection are needed. There exist various studies exploring the potential of natural products for developing new antichlamydial treatment modalities. Polyphenolic compounds can inhibit chlamydial growth by membrane disruption, reestablishment of host cell apoptosis, or improving host immune system detection. Fatty acids, monoglycerides, and lipids can disrupt the cell membranes of infective chlamydial elementary bodies (EBs. Peptides can disrupt the cell membranes of chlamydial EBs, and transferrins can inhibit chlamydial EBs from attachment to and permeation through the membranes of host cells. Cellular metabolites and probiotic bacteria can inhibit chlamydial infection by modulating host immune responses and directly inhibiting chlamydial growth. Finally, early stage clinical trials indicate that polyherbal formulations can be effective in treating chlamydial infections. Herein, we review an important body of literature in the field of antichlamydial research.

  4. On the nature of the new product strategy

    DEFF Research Database (Denmark)

    Larsson, Flemming

    2006-01-01

    The aim of this paper is to explore the concept of a new product strategy and its relation to portfolio management for product development. Based on a literature review this research adheres to one perception of the new product strategy proposed by literature complemented with a component adressing...... the risk-dimension. Next, it is suggested that the new product strategy is embedded in the product development strategy. Subsequently, it is advocated that companies try to achieve a base for realizing integration, synchronization and strategic alignment by means of a new product strategy. These three...... themes are explicated in a model, which also indicates the relation between the new product strategy and the product development process. Finally, implications for management practice are devised....

  5. Liquefied natural gas production at Hammerfest: A transforming marine community

    NARCIS (Netherlands)

    Bets, van L.K.J.; Tatenhove, van J.P.M.; Mol, A.P.J.

    2016-01-01

    Global energy demand and scarce petroleum resources require communities to adapt to a rapidly changing Arctic environment, but as well to a transforming socio-economic environment instigated by oil and gas development. This is illustrated by liquefied natural gas production by Statoil at Hammerfest,

  6. Chemistry of natural products: A veritable approach to the ...

    African Journals Online (AJOL)

    Even with the advent of newer technologies such as combinatorial chemistry, robotics, high throughput screening (HTS), bioinformatics, and in silico molecular modelling, natural products still play a crucial role in drug discovery. This is because they provide an unparalleled range of chemical diversity on which the newer ...

  7. Learning Organic Chemistry Through Natural Products A Practical ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 1; Issue 9. Learning Organic Chemistry Through Natural Products A Practical Approach. N R Krishnaswamy. Series Article Volume 1 Issue 9 September 1996 pp 25-33. Fulltext. Click here to view fulltext PDF. Permanent link:

  8. Natural gas for power production in Western Europe

    International Nuclear Information System (INIS)

    1993-01-01

    The third and last part of the Sub-Committee's study on natural gas for power generation is reprinted in this issue. This part addresses gas consumption in electricity production until the year 2010. The first part of the study dealing with combined cycle power plants was published in September and the 2nd part on regulatory and environmental issues in October 1992

  9. The sustainable management of a productive natural capital

    DEFF Research Database (Denmark)

    Daubanes, Julien Xavier

    is relevant, among other examples, to the case of naturebased tourism. I study the sustainable management of a productive natural capital: the conditions under which its exploitation generates maximum long-run social benefits; the various ways in which a regulator can implement such an exploitation; the rent...

  10. Gamma radiodecontamination of natural products uses in Cuban pharmaceutical industry

    International Nuclear Information System (INIS)

    Rodriguez, M.; Lopez, M.; Guerra, M.; Lastra, H.; Prieto, E.; Padron, E.

    1997-01-01

    The aim of the present paper was to carry out the gamma radiodecontamination of industrial productions from there medicinal plant species (C. officinalis, P. incarta and M. recuttia) and two pharmaceuticals forms (S. platensis and bee pollen tabs) which presented high levels of microbiological count. Adequate irradiation doses calculated for each product were used in decontamination. The results obtained showed the effectiveness of the process in the elimination of microbial contamination from theses natural products. No changes in nutritional constituents or physico-chemical properties were observed

  11. Understanding European education landscape on natural disasters - a textbook research

    Science.gov (United States)

    Komac, B.; Zorn, M.; Ciglič, R.; Steinführer, A.

    2012-04-01

    The importance of natural-disaster education for social preparedness is presented. Increasing damage caused by natural disasters around the globe draws attention to the fact that even developed societies must adapt to natural processes. Natural-disaster education is a component part of any education strategy for a sustainably oriented society. The purpose of this article is to present the role of formal education in natural disasters in Europe. To ensure a uniform overview, the study used secondary-school geography textbooks from the collection at the Georg Eckert Institute for International Textbook Research in Braunschweig, Germany. Altogether, nearly 190 textbooks from 35 European countries were examined. The greatest focus on natural disasters can be found in textbooks published in western Europe (3.8% of pages describing natural disasters), and the smallest in those published in eastern Europe (0.7%). A share of textbook pages exceeding three percent describing natural disasters can also be found in northern Europe (3.6%) and southeast Europe, including Turkey (3.4%). The shares in central and southern Europe exceed two percent (i.e., 2.8% and 2.3%, respectively). The types and specific examples of natural disasters most commonly covered in textbooks as well as the type of natural disasters presented in textbooks according to the number of casualties and the damage caused were analyzed. The results show that the majority of European (secondary-school) education systems are poorly developed in terms of natural-disaster education. If education is perceived as part of natural-disaster management and governance, greater attention should clearly be dedicated to this activity. In addition to formal education, informal education also raises a series of questions connected with the importance of this type of education. Special attention was drawn to the importance of knowledge that locals have about their region because this aspect of education is important in both

  12. Cooling Performance of Natural Circulation for a Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Park, Suki; Chun, J. H.; Yum, S. B. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    This paper deals with the core cooling performance by natural circulation during normal operation and a flow channel blockage event in an open tank-in-pool type research reactor. The cooling performance is predicted by using the RELAP5/ MOD3.3 code. The core decay heat is usually removed by natural circulation to the reactor pool water in open tank-in-pool type research reactors with the thermal power less than several megawatts. Therefore, these reactors have generally no active core cooling system against a loss of normal forced flow. In reactors with the thermal power less than around one megawatt, the reactor core can be cooled down by natural circulation even during normal full power operation. The cooling performance of natural circulation in an open tank-in-pool type research reactor has been investigated during the normal natural circulation and a flow channel blockage event. It is found that the maximum powers without void generation at the hot channel are around 1.16 MW and 820 kW, respectively, for the normal natural circulation and the flow channel blockage event.

  13. Exploitation of Aspergillus terreus for the Production of Natural Statins

    Directory of Open Access Journals (Sweden)

    Mishal Subhan

    2016-04-01

    Full Text Available The fungus Aspergillus (A. terreus has dominated the biological production of the “blockbuster” drugs known as statins. The statins are a class of drugs that inhibit HMG-CoA reductase and lead to lower cholesterol production. The statins were initially discovered in fungi and for many years fungi were the sole source for the statins. At present, novel chemically synthesised statins are produced as inspired by the naturally occurring statin molecules. The isolation of the natural statins, compactin, mevastatin and lovastatin from A. terreus represents one of the great achievements of industrial microbiology. Here we review the discovery of statins, along with strategies that have been applied to scale up their production by A. terreus strains. The strategies encompass many of the techniques available in industrial microbiology and include the optimization of media and fermentation conditions, the improvement of strains through classical mutagenesis, induced genetic manipulation and the use of statistical design.

  14. Discovery and characterization of natural products that act as pheromones in fish.

    Science.gov (United States)

    Li, Ke; Buchinger, Tyler J; Li, Weiming

    2018-06-20

    Covering: up to 2018 Fish use a diverse collection of molecules to communicate with conspecifics. Since Karlson and Lüscher termed these molecules 'pheromones', chemists and biologists have joined efforts to characterize their structures and functions. In particular, the understanding of insect pheromones developed at a rapid pace, set, in part, by the use of bioassay-guided fractionation and natural product chemistry. Research on vertebrate pheromones, however, has progressed more slowly. Initially, biologists characterized fish pheromones by screening commercially available compounds suspected to act as pheromones based upon their physiological function. Such biology-driven screening has proven a productive approach to studying pheromones in fish. However, the many functions of fish pheromones and diverse metabolites that fish release make predicting pheromone identity difficult and necessitate approaches led by chemistry. Indeed, the few cases in which pheromone identification was led by natural product chemistry indicated novel or otherwise unpredicted compounds act as pheromones. Here, we provide a brief review of the approaches to identifying pheromones, placing particular emphasis on the promise of using natural product chemistry together with assays of biological activity. Several case studies illustrate bioassay-guided fractionation as an approach to pheromone identification in fish and the unexpected diversity of pheromone structures discovered by natural product chemistry. With recent advances in natural product chemistry, bioassay-guided fractionation is likely to unveil an even broader collection of pheromone structures and enable research that spans across disciplines.

  15. Box: Natural Language Processing Research Using Amazon Web Services

    Directory of Open Access Journals (Sweden)

    Axelrod Amittai

    2015-10-01

    Full Text Available We present a publicly-available state-of-the-art research and development platform for Machine Translation and Natural Language Processing that runs on the Amazon Elastic Compute Cloud. This provides a standardized research environment for all users, and enables perfect reproducibility and compatibility. Box also enables users to use their hardware budget to avoid the management and logistical overhead of maintaining a research lab, yet still participate in global research community with the same state-of-the-art tools.

  16. Natural radioactivity and estimated dose in Brazilian tobacco products

    International Nuclear Information System (INIS)

    Oliveira, Aline S.G.R. de; Damatto, Sandra R.

    2017-01-01

    Tobacco products contain significant concentrations of natural radionuclides from 238 U and 232 Th series. The consumption of these products increases the internal dose of radiation due to the inhalation of the natural radionuclides. Studies from literature emphasize that tobacco products have measurable concentrations of 210 Po and 210 Pb, and may contribute significantly to the increase of internal radiation dose and a large number of lung cancer in smokers. The objectives of this work were to determine the concentrations (Bq/kg) of the radionuclides 226 Ra, 228 Ra, 210 Pb and 210 Po and calculate the internal doses of radiation due to the consumption of these products. In the present work 71 samples were analyzed, consisting of cigars, unflavored and flavored cigarettes, straw cigarettes, cigars and roll smoke. The samples were purchased in Brazilian popular commercial establishments. The analytical techniques employed were the gross alpha and beta measurement after radiochemical separation for the radionuclides 226 Ra, 228 Ra, 210 Pb and alpha spectrometry for 210 Po. The internal radiation doses were calculated with the activity concentrations determined and using the ICRP Publication 119 dose coefficients. An annual consumption of 3,650 kg of tobacco products was considered. The inhalation rates of each radionuclide followed the rates of the current literature. The estimated mean annual dose varied from 76 to 263μSv/y for the tobacco product studied in this work. (author)

  17. Natural radioactivity and estimated dose in Brazilian tobacco products

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Aline S.G.R. de; Damatto, Sandra R., E-mail: aline.oliveira@ipen.br, E-mail: damatto@ipen.br [Instituto de Pesquisas Energéticas e Nucleares (IPEN/CNEN-SP), São Paulo, SP (Brazil)

    2017-07-01

    Tobacco products contain significant concentrations of natural radionuclides from {sup 238}U and {sup 232}Th series. The consumption of these products increases the internal dose of radiation due to the inhalation of the natural radionuclides. Studies from literature emphasize that tobacco products have measurable concentrations of {sup 210}Po and {sup 210}Pb, and may contribute significantly to the increase of internal radiation dose and a large number of lung cancer in smokers. The objectives of this work were to determine the concentrations (Bq/kg) of the radionuclides {sup 226}Ra, {sup 228}Ra, {sup 210}Pb and {sup 210}Po and calculate the internal doses of radiation due to the consumption of these products. In the present work 71 samples were analyzed, consisting of cigars, unflavored and flavored cigarettes, straw cigarettes, cigars and roll smoke. The samples were purchased in Brazilian popular commercial establishments. The analytical techniques employed were the gross alpha and beta measurement after radiochemical separation for the radionuclides {sup 226}Ra, {sup 228}Ra, {sup 210}Pb and alpha spectrometry for {sup 210}Po. The internal radiation doses were calculated with the activity concentrations determined and using the ICRP Publication 119 dose coefficients. An annual consumption of 3,650 kg of tobacco products was considered. The inhalation rates of each radionuclide followed the rates of the current literature. The estimated mean annual dose varied from 76 to 263μSv/y for the tobacco product studied in this work. (author)

  18. Measuring the productivity of university research reactors

    International Nuclear Information System (INIS)

    Voth, M.H.

    1989-01-01

    University Research Reactors (URRs) on 33 campuses in the United States provide valuable contributions to academic instruction and research programs. In most cases, there are no alternative diagnostic techniques to supplant the need for a reactor and associated facilities. Since URRs constitute a major financial commitment, it is important that they be operated in a productive manner. Productivity may be defined as the sum of new knowledge generated, existing knowledge transferred to others, and analytical services provided to assist in the generation of new knowledge; another definition of productivity is this sum expressed as a function of the cost incurred. In either case, a consistent measurement is difficult and more qualitative than quantitative. A uniform reporting system has been proposed that defines simplified categories through which meaningful comparisons can be performed

  19. Structural modeling of natural citrus products as potential cross ...

    African Journals Online (AJOL)

    There are four serotypes of Dengue virus and there are existing drugs used against specific serotype. There is no drug that is effective against all strains of this virus. In this research, bioinformatics tools were used to predict the affinity of natural ligands for the glycoprotein E of Dengue virus by considering the conserved ...

  20. Natural computing for mechanical systems research: A tutorial overview

    Science.gov (United States)

    Worden, Keith; Staszewski, Wieslaw J.; Hensman, James J.

    2011-01-01

    A great many computational algorithms developed over the past half-century have been motivated or suggested by biological systems or processes, the most well-known being the artificial neural networks. These algorithms are commonly grouped together under the terms soft or natural computing. A property shared by most natural computing algorithms is that they allow exploration of, or learning from, data. This property has proved extremely valuable in the solution of many diverse problems in science and engineering. The current paper is intended as a tutorial overview of the basic theory of some of the most common methods of natural computing as they are applied in the context of mechanical systems research. The application of some of the main algorithms is illustrated using case studies. The paper also attempts to give some indication as to which of the algorithms emerging now from the machine learning community are likely to be important for mechanical systems research in the future.

  1. Horse Rock Ridge Research Natural Area: guidebook supplement 27.

    Science.gov (United States)

    Alan B. Curtis

    2003-01-01

    Horse Rock Ridge Research Natural Area (HRR RNA) was established in June 1995 to protect the best remaining example of a grassy “bald” (treeless area) on the western margin of the Cascade Range and its associated botanical, wildlife, and scenic values. This bald is surrounded by old-growth Pseudotsuga menziesii/Tsuga heterophylla...

  2. Forest Creeks Research Natural Area: guidebook supplement 39

    Science.gov (United States)

    Reid Schuller; Ron Halvorson

    2010-01-01

    This guidebook describes Forest Creeks Research Natural Area, a 164-ha (405-ac) area comprising two geographically distinct canyons and associated drainages. The two units have been established as examples of first- to third-order streams originating within a ponderosa pine (Pinus ponderosa) zone. The two riparian areas also represent examples of...

  3. Cherry Creek Research Natural Area: guidebook supplement 41

    Science.gov (United States)

    Reid Schuller; Jennie Sperling; Tim Rodenkirk

    2011-01-01

    This guidebook describes Cherry Creek Research Natural Area, a 239-ha (590-ac) area that supports old-growth Douglas-fir-western hemlock (Pseudotsuga menziesii- Tsuga heterophylla) forest occurring on sedimentary materials in the southern Oregon Coast Range. Major plant associations present within the area include the western hemlock/Oregon oxalis...

  4. Fish Creek Rim Research Natural Area: guidebook supplement 50

    Science.gov (United States)

    Reid Schuller; Ian Grinter

    2016-01-01

    This guidebook describes major biological and physical attributes of the 3531-ha (8,725-ac) Fish Creek Rim Research Natural Area located within the Northern Basin and Range ecoregion and managed by the Bureau of Land Management, Lakeview District (USDI BLM 2003).

  5. Partnerships panel: natural, resource partnerships: literature synthesis and research agenda

    Science.gov (United States)

    Steve Selin; Nancy Myers

    1995-01-01

    This paper presents a summary of an annotated bibliography on natural resource partnerships. Resource areas and management functions addressed in the partnership literature are examined. Partnership research is summarized and broken into categories including: Partnership outcomes, assessing the potential for partnerships, characteristics of successful partnerships,...

  6. Evolution of natural risk: research framework and perspectives

    Science.gov (United States)

    Hufschmidt, G.; Crozier, M.; Glade, T.

    2005-05-01

    This study presents a conceptual framework for addressing temporal variation in natural risk. Numerous former natural risk analyses and investigations have demonstrated that time and related changes have a crucial influence on risk. For natural hazards, time becomes a factor for a number of reasons. Using the example of landslides to illustrate this point, it is shown that: 1. landslide history is important in determining probability of occurrence, 2. the significance of catchment variables in explaining landslide susceptibility is dependent on the time scale chosen, 3. the observer's perception of the geosystem's state changes with different time spans, and 4. the system's sensitivity varies with time. Natural hazards are not isolated events but complex features that are connected with the social system. Similarly, elements at risk and their vulnerability are highly dynamic through time, an aspect that is not sufficiently acknowledged in research. Since natural risk is an amalgam of hazard and vulnerability, its temporal behaviour has to be considered as well. Identifying these changes and their underlying processes contributes to a better understanding of natural risk today and in the future. However, no dynamic models for natural risks are currently available. Dynamic behaviour of factors affecting risk is likely to create increasing connectivity and complexity. This demands a broad approach to natural risk, since the concept of risk encapsulates aspects of many disciplines and has suffered from single-discipline approaches in the past. In New Zealand, dramatic environmental and social change has occurred in a relatively short period of time, graphically demonstrating the temporal variability of the geosystem and the social system. To understand these changes and subsequent interactions between both systems, a holistic perspective is needed. This contribution reviews available frameworks, demonstrates the need for further concepts, and gives research

  7. Dietary Natural Products for Prevention and Treatment of Breast Cancer.

    Science.gov (United States)

    Li, Ya; Li, Sha; Meng, Xiao; Gan, Ren-You; Zhang, Jiao-Jiao; Li, Hua-Bin

    2017-07-08

    Breast cancer is the most common cancer among females worldwide. Several epidemiological studies suggested the inverse correlation between the intake of vegetables and fruits and the incidence of breast cancer. Substantial experimental studies indicated that many dietary natural products could affect the development and progression of breast cancer, such as soy, pomegranate, mangosteen, citrus fruits, apple, grape, mango, cruciferous vegetables, ginger, garlic, black cumin, edible macro-fungi, and cereals. Their anti-breast cancer effects involve various mechanisms of action, such as downregulating ER-α expression and activity, inhibiting proliferation, migration, metastasis and angiogenesis of breast tumor cells, inducing apoptosis and cell cycle arrest, and sensitizing breast tumor cells to radiotherapy and chemotherapy. This review summarizes the potential role of dietary natural products and their major bioactive components in prevention and treatment of breast cancer, and special attention was paid to the mechanisms of action.

  8. Marine natural products: a new wave of drugs?

    Science.gov (United States)

    Montaser, Rana; Luesch, Hendrik

    2011-01-01

    The largely unexplored marine world that presumably harbors the most biodiversity may be the vastest resource to discover novel ‘validated’ structures with novel modes of action that cover biologically relevant chemical space. Several challenges, including the supply problem and target identification, need to be met for successful drug development of these often complex molecules; however, approaches are available to overcome the hurdles. Advances in technologies such as sampling strategies, nanoscale NMR for structure determination, total chemical synthesis, fermentation and biotechnology are all crucial to the success of marine natural products as drug leads. We illustrate the high degree of innovation in the field of marine natural products, which in our view will lead to a new wave of drugs that flow into the market and pharmacies in the future. PMID:21882941

  9. What Is the Structure of the Antitubercular Natural Product Eucapsitrione?

    Science.gov (United States)

    Pullella, Glenn A; Wild, Duncan A; Nealon, Gareth L; Elyashberg, Mikhail; Piggott, Matthew J

    2017-07-21

    1,5,7-Trihydroxy-6H-indeno[1,2-b]anthracene-6,11,13-trione (1), proposed to be the antitubercular natural product eucapsitrione, has been synthesized in 43% overall yield and six steps, including a key Suzuki-Miyaura biaryl coupling and a directed remote metalation (DReM)-initiated cyclization. The physical and spectroscopic properties of 1 do not match the data reported for the natural product. At this time there is insufficient information available to enable a structure reassignment. During the optimization of the Suzuki-Miyaura coupling, an unprecedented biaryl coupling ortho to the borono group was observed. The scope of this unusual reaction has been investigated.

  10. Challenges and solutions in natural gas engine development and productions

    Energy Technology Data Exchange (ETDEWEB)

    Ahmadi, Mahdi; Izanloo, Hossein [Irankhodro Powertrain Co. (IPCO) (Iran)

    2008-07-01

    As an alternative fuel, natural gas is generally accepted for internal combustion engines and some developments have been conducted in order to adopt it for the road vehicles and stationary applications. Foresights shows natural gas vehicles will be a part of the future transportation technology regarding to their mid and long-term benefits. Therefore inherent problems of natural gas engine technology should be overcome to produce a competitive engine. In this paper major problems and their possible solutions in developing and producing natural gas engine for passenger cars are detailed and discussed. Challenging materials are sorted and presented in two categorizes: technical and econo-strategical problems. In the technical section major difficulties faced in components or systems of natural gas engine are analysed in different aspects of design, validation, and production. In addition problems arisen from the fuel characteristics which influence the function and durability of engine are argued. Subjects like freezing in gas regulator, cold start fuel injection, gas leakage, impurities within compressed natural gas, variation in fuel composition, thermo-mechanics of cylinder head and block, wear of valve seat inserts, spark plug erosion, back-fire phenomenon, engine oil quality requirement, low power density and mileage are described. In the econo-strategical discussion, challenges like limited gas distribution infrastructure, lack of specific manufacturing standards and codes, and non-dedicated emission standards are explained. In both part of the paper a comprehensive view is extended to clarify the effect, risk and solutions of each problem. Due to the fact that almost all information and analysis presented in this paper are based on the experience of developing a natural gas engine family, and an extensive literature review, discussions and conclusions could be useful as a guide line for future natural gas engine projects. (orig.)

  11. Natural Products for the Treatment of Type 2 Diabetes Mellitus.

    Science.gov (United States)

    Ríos, José Luis; Francini, Flavio; Schinella, Guillermo R

    2015-08-01

    Type 2 diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia. High blood sugar can produce long-term complications such as cardiovascular and renal disorders, retinopathy, and poor blood flow. Its development can be prevented or delayed in people with impaired glucose tolerance by implementing lifestyle changes or the use of therapeutic agents. Some of these drugs have been obtained from plants or have a microbial origin, such as galegine isolated from Galega officinalis, which has a great similarity to the antidiabetic drug metformin. Picnogenol, acarbose, miglitol, and voglibose are other antidiabetic products of natural origin. This review compiles the principal articles on medicinal plants used for treating diabetes and its comorbidities, as well as mechanisms of natural products as antidiabetic agents. Inhibition of α-glucosidase and α-amylase, effects on glucose uptake and glucose transporters, modification of mechanisms mediated by the peroxisome proliferator-activated receptor, inhibition of protein tyrosine phosphatase 1B activity, modification of gene expression, and activities of hormones involved in glucose homeostasis such as adiponectin, resistin, and incretin, and reduction of oxidative stress are some of the mechanisms in which natural products are involved. We also review the most relevant clinical trials performed with medicinal plants and natural products such as aloe, banaba, bitter melon, caper, cinnamon, cocoa, coffee, fenugreek, garlic, guava, gymnema, nettle, sage, soybean, green and black tea, turmeric, walnut, and yerba mate. Compounds of high interest as potential antidiabetics are: fukugetin, palmatine, berberine, honokiol, amorfrutins, trigonelline, gymnemic acids, gurmarin, and phlorizin. Georg Thieme Verlag KG Stuttgart · New York.

  12. Cytotoxic Natural Products from Marine Sponge-Derived Microorganisms

    Directory of Open Access Journals (Sweden)

    Huawei Zhang

    2017-03-01

    Full Text Available A growing body of evidence indicates that marine sponge-derived microbes possess the potential ability to make prolific natural products with therapeutic effects. This review for the first time provides a comprehensive overview of new cytotoxic agents from these marine microbes over the last 62 years from 1955 to 2016, which are assorted into seven types: terpenes, alkaloids, peptides, aromatics, lactones, steroids, and miscellaneous compounds.

  13. Dietary Natural Products for Prevention and Treatment of Breast Cancer

    OpenAIRE

    Li, Ya; Li, Sha; Meng, Xiao; Gan, Ren-You; Zhang, Jiao-Jiao; Li, Hua-Bin

    2017-01-01

    Breast cancer is the most common cancer among females worldwide. Several epidemiological studies suggested the inverse correlation between the intake of vegetables and fruits and the incidence of breast cancer. Substantial experimental studies indicated that many dietary natural products could affect the development and progression of breast cancer, such as soy, pomegranate, mangosteen, citrus fruits, apple, grape, mango, cruciferous vegetables, ginger, garlic, black cumin, edible macro-fungi...

  14. Rationale for a natural products approach to herbicide discovery.

    Science.gov (United States)

    Dayan, Franck E; Owens, Daniel K; Duke, Stephen O

    2012-04-01

    Weeds continue to evolve resistance to all the known modes of herbicidal action, but no herbicide with a new target site has been commercialized in nearly 20 years. The so-called 'new chemistries' are simply molecules belonging to new chemical classes that have the same mechanisms of action as older herbicides (e.g. the protoporphyrinogen-oxidase-inhibiting pyrimidinedione saflufenacil or the very-long-chain fatty acid elongase targeting sulfonylisoxazoline herbicide pyroxasulfone). Therefore, the number of tools to manage weeds, and in particular those that can control herbicide-resistant weeds, is diminishing rapidly. There is an imminent need for truly innovative classes of herbicides that explore chemical spaces and interact with target sites not previously exploited by older active ingredients. This review proposes a rationale for a natural-products-centered approach to herbicide discovery that capitalizes on the structural diversity and ingenuity afforded by these biologically active compounds. The natural process of extended-throughput screening (high number of compounds tested on many potential target sites over long periods of times) that has shaped the evolution of natural products tends to generate molecules tailored to interact with specific target sites. As this review shows, there is generally little overlap between the mode of action of natural and synthetic phytotoxins, and more emphasis should be placed on applying methods that have proved beneficial to the pharmaceutical industry to solve problems in the agrochemical industry. Published 2012 by John Wiley & Sons, Ltd.

  15. Automated genome mining of ribosomal peptide natural products

    Energy Technology Data Exchange (ETDEWEB)

    Mohimani, Hosein; Kersten, Roland; Liu, Wei; Wang, Mingxun; Purvine, Samuel O.; Wu, Si; Brewer, Heather M.; Pasa-Tolic, Ljiljana; Bandeira, Nuno; Moore, Bradley S.; Pevzner, Pavel A.; Dorrestein, Pieter C.

    2014-07-31

    Ribosomally synthesized and posttranslationally modified peptides (RiPPs), especially from microbial sources, are a large group of bioactive natural products that are a promising source of new (bio)chemistry and bioactivity (1). In light of exponentially increasing microbial genome databases and improved mass spectrometry (MS)-based metabolomic platforms, there is a need for computational tools that connect natural product genotypes predicted from microbial genome sequences with their corresponding chemotypes from metabolomic datasets. Here, we introduce RiPPquest, a tandem mass spectrometry database search tool for identification of microbial RiPPs and apply it for lanthipeptide discovery. RiPPquest uses genomics to limit search space to the vicinity of RiPP biosynthetic genes and proteomics to analyze extensive peptide modifications and compute p-values of peptide-spectrum matches (PSMs). We highlight RiPPquest by connection of multiple RiPPs from extracts of Streptomyces to their gene clusters and by the discovery of a new class III lanthipeptide, informatipeptin, from Streptomyces viridochromogenes DSM 40736 as the first natural product to be identified in an automated fashion by genome mining. The presented tool is available at cy-clo.ucsd.edu.

  16. Natural Radiation in byproducts of the production of phosphoric acid

    International Nuclear Information System (INIS)

    Silveira, Marcilei A. Guazzelli da; Cardoso, L.L.; Medina, N.H.

    2014-01-01

    Natural radiation is the largest source of radiation exposure to which man is subject. It is formed basically by cosmic radiation and the radionuclides present in the Earth crust, as 40 K and the elements of the decay series of 232 Th and 238 U. Phosphate ores, which constitutes the raw material for the production of phosphoric acid, have a high rate of natural radiation from the decay series of 232 Th and 238 U. Phosphogypsum, which is naturally radioactivity, is a by-product of the production of phosphoric acid by the wet method. For each ton of phosphoric acid it is produced about 4.5 tons of phosphogypsum. This work presents the analysis of samples collected in all stages of the manufacturing process of phosphoric acid, which generates the phosphogypsum. Gamma-ray spectrometry was used to measure the concentration of the elements of the decay series of 232 Th and 238 U. All analyzed samples showed a high concentration of radionuclides, promoting the need for further steps in the process in order to reduce the presence of such radionuclides in the phosphogypsum. The results indicate the radionuclide 238 U has higher contribution in some samples of the intermediate stages of the process. All samples exceeded the international average range of human exposure to terrestrial gamma radiation, which is 0.3 to 1.0 mSv/year. (author)

  17. Contact heating of water products of combustion of natural gas

    Energy Technology Data Exchange (ETDEWEB)

    Aronov, I Z

    1978-01-01

    The USSR's NIIST examined the processes and equipment for heating water by submerged combustion using natural gas. Written for engineers involved with the design and application of thermal engineering equipment operating with natural gas, the book emphasizes equipment, test results, and methods of calculating heat transfer for contact gas economizers developed by Scientific Research Institute of Sanitary Engineering and other Soviet organizations. The economic effectiveness of submerged-combustion heating depends on several factors, including equipment design. Recommendations cover cost-effective designs and applications of contact economizers and boilers.

  18. Production, consumption and research on solar energy

    DEFF Research Database (Denmark)

    Sanz-Casado, Elias; Lascurain-Sánchez, Maria Luisa; Serrano-Lopez, Antonio Eleazar

    2014-01-01

    An analysis of scientific publications on solar energy was conducted to determine whether public interest in the subject is mirrored by more intense research in the area. To this end, the research published by Spain and Germany, the two EU countries with the highest installed photovoltaic capacity......, was analyzed based on Web of Science data. The results show that: solar output has risen substantially; solar research has a greater impact (measured in terms of citations) than publications on other renewables such as wind power; scientific production on solar energy is high in Germany and Spain, which...... intense. The main conclusion is the divergence in Germany and Spain between solar energy demand/output growth, being exponential, and the growth of research papers on the subject, which is linear...

  19. Marine actinobacteria associated with marine organisms and their potentials in producing pharmaceutical natural products.

    Science.gov (United States)

    Valliappan, Karuppiah; Sun, Wei; Li, Zhiyong

    2014-09-01

    Actinobacteria are ubiquitous in the marine environment, playing an important ecological role in the recycling of refractory biomaterials and producing novel natural products with pharmic applications. Actinobacteria have been detected or isolated from the marine creatures such as sponges, corals, mollusks, ascidians, seaweeds, and seagrass. Marine organism-associated actinobacterial 16S rRNA gene sequences, i.e., 3,003 sequences, deposited in the NCBI database clearly revealed enormous numbers of actinobacteria associated with marine organisms. For example, RDP classification of these sequences showed that 112 and 62 actinobacterial genera were associated with the sponges and corals, respectively. In most cases, it is expected that these actinobacteria protect the host against pathogens by producing bioactive compounds. Natural products investigation and functional gene screening of the actinobacteria associated with the marine organisms revealed that they can synthesize numerous natural products including polyketides, isoprenoids, phenazines, peptides, indolocarbazoles, sterols, and others. These compounds showed anticancer, antimicrobial, antiparasitic, neurological, antioxidant, and anti-HIV activities. Therefore, marine organism-associated actinobacteria represent an important resource for marine drugs. It is an upcoming field of research to search for novel actinobacteria and pharmaceutical natural products from actinobacteria associated with the marine organisms. In this review, we attempt to summarize the present knowledge on the diversity and natural products production of actinobacteria associated with the marine organisms, based on the publications from 1991 to 2013.

  20. Marine natural products in prevention and treatment of osteoporosis

    Directory of Open Access Journals (Sweden)

    Zahra Ghanbari

    2015-05-01

    Full Text Available Undoubtedly, pharmaceutical and nutritional factors play an important role in the prevention of age-related bone loss. According to the several studies so far, the effects of nutrients and bioactive components which are extracted from marine resources are very promising in osteoporosis. Most of these investigations have been done on various marine algae extracts. Since, algae are rich source of essential minerals, primary and secondary unique natural products, several amino acids and growth factors their extracts show favorable effects on bone metabolism. Moreover, it has been shown that marine nutrients such as marine fishes, shrimp and crabs increase the absorption of calcium and bone collagen synthesis or reduce the production of prostaglandins and decrease the deoxypyridinoline disposal. On the other hand, secondary products which are extracted and characterized from marine organisms such as mollusks, fungi, bacteria, sponges and coral reefs show anti-osteoporosis activities via the inhibition of osteoclast differentiation and the induction of apoptosis in osteoclasts like cells or stimulation of osteoblast differentiation. Although, several investigations have been done in this area, many of studies have been carried out on animal models, like ovariectomy-induced bone loss in mice. Hence, clinical investigations are warranted to develop marine natural products against bone loss and to prevent osteoporosis.

  1. The water-food nexus of natural rubber production

    Science.gov (United States)

    Chiarelli, D. D.; Rosa, L.; Rulli, M. C.; D'Odorico, P.

    2017-12-01

    The increasing global demand for natural rubber (100% increase in the last 15 years) is for most part met by Malaysia and Indonesia, and - to a lesser extent - other countries in south-east Asia and Africa. The consequent expansion of rubber plantation has often occurred at the expenses of agricultural land for staple food, particularly in southeast Asia, where most of the land suitable for agriculture is already harvested for food crops or other uses. Here we investigate the extent to which the ongoing increase in rubber production is competing with the food system and affecting the livelihoods of rural communities in the areas of production and their appropriation of natural resources, such as water. We also investigate to what extent the expansion of rubber plantations is taking place through large scale land acquisitions (LSLAs) and evaluate the impacts on rural communities. Our results show how rubber production has strong environmental, social and economic impacts. Despite their ability to bring employment and increase the average income of economically disadvantaged areas, rubber plantations may threaten the local water and food security and induce a loss of rural livelihoods, particularly when the new plantations result from LSLAs that displace semi-subsistence forms of production thereby forcing the local populations to depend on global markets.

  2. Factors that impact interdisciplinary natural science research collaboration in academia

    DEFF Research Database (Denmark)

    Maglaughlin, Kelly L.; Sonnenwald, Diane H.

    2005-01-01

    to provide a more comprehensive understanding of interdisciplinary scientific research collaboration within the natural sciences in academia. Data analysis confirmed factors previously identified in various literatures and yielded new factors. A total of twenty factors were identified, and classified......Interdisciplinary collaboration occurs when people with different educational and research backgrounds bring complementary skills to bear on a problem or task. The strength of interdisciplinary scientific research collaboration is its capacity to bring together diverse scientific knowledge...... to address complex problems and questions. However, interdisciplinary scientific research can be difficult to initiate and sustain. We do not yet fully understand factors that impact interdisciplinary scientific research collaboration. This study synthesizes empirical data from two empirical studies...

  3. Investigating the Structure-Activity Relationship of the Insecticidal Natural Product Rocaglamide.

    Science.gov (United States)

    Hall, Roger G; Bruce, Ian; Cooke, Nigel G; Diorazio, Louis J; Cederbaum, Fredrik; Dobler, Markus R; Irving, Ed

    2017-12-01

    The natural product Rocaglamide (1), isolated from the tree Aglaia elliptifolia, is a compelling but also challenging lead structure for crop protection. In laboratory assays, the natural product shows highly interesting insecticidal activity against chewing pests and beetles, but also phytotoxicity on some crop plants. Multi-step syntheses with control of stereochemistry were required to probe the structure-activity relationship (SAR), and seek simplified analogues. After a significant research effort, just two areas of the molecule were identified which allow modification whilst maintaining activity, as will be highlighted in this paper.

  4. Natural and Accelerated Bioremediation Research (NABIR) Field Research Center (FRC) Management Plan

    Energy Technology Data Exchange (ETDEWEB)

    Watson, D.B.

    2002-02-28

    The Environmental Sciences Division at Oak Ridge National Laboratory has established a Field Research Center (FRC) to support the Natural and Accelerated Bioremediation Research (NABIR) Program on the U.S. Department of Energy (DOE) Oak Ridge Reservation in Oak Ridge, Tennessee for the DOE Headquarters Office of Biological and Environmental Research within the Office of Science.

  5. Collaboration networks and research productivity at IPEN

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, Carlos Anisio; Barroso, Antonio Carlos de Oliveira, E-mail: monteiro@ipen.br, E-mail: barroso@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2015-07-01

    In this article, we investigate the IPEN's scientific collaboration network. Based on publications registered in IPEN's technical and scientific database was extracted a set of authors that developed technical and scientific work on the 2001 to 2010 period, using coauthorship to define the relationship between authors. From the data collected, we used degree centrality indicator in conjunction with two approaches to assess the relationship between collaboration and productivity: normal count, where for each publication that the author appears is added one for the author’s productivity indicator, and fractional count which is added a fractional value according to the total number of publication's authors. We concluded that collaboration for the development of a technical and scientific work has a positive correlation with the researchers productivity, that is, the greater the collaboration greater the productivity. We presented, also, a statistical summary to reveal the total number of publications and the number of IPEN's authors by publication, the average number of IPEN's authors per publication and the average number of publications by IPEN's author, the number of IPEN's authors that not published with no other author of the IPEN and, finally, the number of active and inactive (ex. retirees) researchers of the IPEN, as well as, the number of authors who do not have employment contract with the IPEN. (author)

  6. Collaboration networks and research productivity at IPEN

    International Nuclear Information System (INIS)

    Monteiro, Carlos Anisio; Barroso, Antonio Carlos de Oliveira

    2015-01-01

    In this article, we investigate the IPEN's scientific collaboration network. Based on publications registered in IPEN's technical and scientific database was extracted a set of authors that developed technical and scientific work on the 2001 to 2010 period, using coauthorship to define the relationship between authors. From the data collected, we used degree centrality indicator in conjunction with two approaches to assess the relationship between collaboration and productivity: normal count, where for each publication that the author appears is added one for the author’s productivity indicator, and fractional count which is added a fractional value according to the total number of publication's authors. We concluded that collaboration for the development of a technical and scientific work has a positive correlation with the researchers productivity, that is, the greater the collaboration greater the productivity. We presented, also, a statistical summary to reveal the total number of publications and the number of IPEN's authors by publication, the average number of IPEN's authors per publication and the average number of publications by IPEN's author, the number of IPEN's authors that not published with no other author of the IPEN and, finally, the number of active and inactive (ex. retirees) researchers of the IPEN, as well as, the number of authors who do not have employment contract with the IPEN. (author)

  7. Mimicking a natural pathway for de novo biosynthesis: natural vanillin production from accessible carbon sources.

    Science.gov (United States)

    Ni, Jun; Tao, Fei; Du, Huaiqing; Xu, Ping

    2015-09-02

    Plant secondary metabolites have been attracting people's attention for centuries, due to their potentials; however, their production is still difficult and costly. The rich diversity of microbes and microbial genome sequence data provide unprecedented gene resources that enable to develop efficient artificial pathways in microorganisms. Here, by mimicking a natural pathway of plants using microbial genes, a new metabolic route was developed in E. coli for the synthesis of vanillin, the most widely used flavoring agent. A series of factors were systematically investigated for raising production, including efficiency and suitability of genes, gene dosage, and culture media. The metabolically engineered strain produced 97.2 mg/L vanillin from l-tyrosine, 19.3 mg/L from glucose, 13.3 mg/L from xylose and 24.7 mg/L from glycerol. These results show that the metabolic route enables production of natural vanillin from low-cost substrates, suggesting that it is a good strategy to mimick natural pathways for artificial pathway design.

  8. Mimicking a natural pathway for de novo biosynthesis: natural vanillin production from accessible carbon sources

    Science.gov (United States)

    Ni, Jun; Tao, Fei; Du, Huaiqing; Xu, Ping

    2015-01-01

    Plant secondary metabolites have been attracting people’s attention for centuries, due to their potentials; however, their production is still difficult and costly. The rich diversity of microbes and microbial genome sequence data provide unprecedented gene resources that enable to develop efficient artificial pathways in microorganisms. Here, by mimicking a natural pathway of plants using microbial genes, a new metabolic route was developed in E. coli for the synthesis of vanillin, the most widely used flavoring agent. A series of factors were systematically investigated for raising production, including efficiency and suitability of genes, gene dosage, and culture media. The metabolically engineered strain produced 97.2 mg/L vanillin from l-tyrosine, 19.3 mg/L from glucose, 13.3 mg/L from xylose and 24.7 mg/L from glycerol. These results show that the metabolic route enables production of natural vanillin from low-cost substrates, suggesting that it is a good strategy to mimick natural pathways for artificial pathway design. PMID:26329726

  9. Nature is the best source of anticancer drugs: Indexing natural products for their anticancer bioactivity.

    Science.gov (United States)

    Rayan, Anwar; Raiyn, Jamal; Falah, Mizied

    2017-01-01

    Cancer is considered one of the primary diseases that cause morbidity and mortality in millions of people worldwide and due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. However, the traditional process of drug discovery and development is lengthy and expensive, so the application of in silico techniques and optimization algorithms in drug discovery projects can provide a solution, saving time and costs. A set of 617 approved anticancer drugs, constituting the active domain, and a set of 2,892 natural products, constituting the inactive domain, were employed to build predictive models and to index natural products for their anticancer bioactivity. Using the iterative stochastic elimination optimization technique, we obtained a highly discriminative and robust model, with an area under the curve of 0.95. Twelve natural products that scored highly as potential anticancer drug candidates are disclosed. Searching the scientific literature revealed that few of those molecules (Neoechinulin, Colchicine, and Piperolactam) have already been experimentally screened for their anticancer activity and found active. The other phytochemicals await evaluation for their anticancerous activity in wet lab.

  10. Nature is the best source of anticancer drugs: Indexing natural products for their anticancer bioactivity.

    Directory of Open Access Journals (Sweden)

    Anwar Rayan

    Full Text Available Cancer is considered one of the primary diseases that cause morbidity and mortality in millions of people worldwide and due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. However, the traditional process of drug discovery and development is lengthy and expensive, so the application of in silico techniques and optimization algorithms in drug discovery projects can provide a solution, saving time and costs. A set of 617 approved anticancer drugs, constituting the active domain, and a set of 2,892 natural products, constituting the inactive domain, were employed to build predictive models and to index natural products for their anticancer bioactivity. Using the iterative stochastic elimination optimization technique, we obtained a highly discriminative and robust model, with an area under the curve of 0.95. Twelve natural products that scored highly as potential anticancer drug candidates are disclosed. Searching the scientific literature revealed that few of those molecules (Neoechinulin, Colchicine, and Piperolactam have already been experimentally screened for their anticancer activity and found active. The other phytochemicals await evaluation for their anticancerous activity in wet lab.

  11. Computational Fluid Dynamics Modeling to Improve Natural Flow Rate and Sweet Pepper Productivity in Greenhouse

    OpenAIRE

    W. Limtrakarn; P. Boonmongkol; A. Chompupoung; K. Rungprateepthaworn; J. Kruenate; P. Dechaumphai

    2012-01-01

    Natural flow rate and sweet peppers productivity in tropical greenhouse are improved by CFD simulation is the main objective of this research work. Most of the greenhouse types today are in the arch shape. To develop an improved greenhouse structure for the region, the arch type was built and used as the control model. Mae Sar Mai agriculture research station under the royal project foundation was selected as the field test site. Temperature sensors with data logger were installed to monitor ...

  12. Natural products as potential cancer therapy enhancers: A preclinical update

    Directory of Open Access Journals (Sweden)

    Abed Agbarya

    2014-09-01

    Full Text Available Cancer is a multifactorial disease that arises as a consequence of alterations in many physiological processes. Recently, hallmarks of cancer were suggested that include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis, along with two emerging hallmarks including reprogramming energy metabolism and escaping immune destruction. Treating multifactorial diseases, such as cancer with agents targeting a single target, might provide partial treatment and, in many cases, disappointing cure rates. Epidemiological studies have consistently shown that the regular consumption of fruits and vegetables is strongly associated with a reduced risk of developing chronic diseases, such as cardiovascular diseases and cancer. Since ancient times, plants, herbs, and other natural products have been used as healing agents. Moreover, the majority of the medicinal substances available today have their origin in natural compounds. Traditionally, pharmaceuticals are used to cure diseases, and nutrition and herbs are used to prevent disease and to provide an optimal balance of macro- and micro-nutrients needed for good health. We explored the combination of natural products, dietary nutrition, and cancer chemotherapeutics for improving the efficacy of cancer chemotherapeutics and negating side effects.

  13. Production of hydrogen by thermocatalytic cracking of natural gas

    Energy Technology Data Exchange (ETDEWEB)

    Muradov, N. [Florida Solar Energy Center, Cocoa, FL (United States)

    1996-10-01

    The conventional methods of hydrogen production from natural gas (for example, steam reforming and partial oxidation) are complex, multi-step processes that produce large quantities of CO{sub 2}. The main goal of this project is to develop a technologically simple process for hydrogen production from natural gas (NG) and other hydrocarbon fuels via single-step decomposition of hydrocarbons. This approach eliminates or significantly reduces CO{sub 2} emission. Carbon is a valuable by-product of this process, whereas conventional methods of hydrogen production from NG produce no useful by-products. This approach is based on the use of special catalysts that reduce the maximum temperature of the process from 1400-1500{degrees}C (thermal non-catalytic decomposition of methane) to 500-900{degrees}C. Transition metal based catalysts and various forms of carbon are among the candidate catalysts for the process. This approach can advantageously be used for the development of compact NG reformers for on-site production of hydrogen-methane blends at refueling stations and, also, for the production of hydrogen-rich gas for fuel cell applications. The author extended the search for active methane decomposition catalysts to various modifications of Ni-, Fe-, Mo- and Co-based catalysts. Variation in the operational parameters makes it possible to produce H{sub 2}-CH{sub 4} blends with a wide range of hydrogen concentrations that vary from 15 to 98% by volume. The author found that Ni-based catalysts are more effective at temperatures below 750{degrees}C, whereas Fe-based catalysts are effective at temperatures above 800{degrees}C for the production of hydrogen with purity of 95% v. or higher. The catalytic pyrolysis of liquid hydrocarbons (pentane, gasoline) over Fe-based catalyst was conducted. The author observed the production of a hydrogen-rich gas (hydrogen concentration up to 97% by volume) at a rate of approximately 1L/min.mL of hydrocarbon fuel.

  14. Medicinal plants and natural products in amelioration of arsenic toxicity: a short review.

    Science.gov (United States)

    Bhattacharya, Sanjib

    2017-12-01

    Chronic arsenic toxicity (arsenicosis) is considered a serious public health menace worldwide, as there is no specific, safe, and efficacious therapeutic management of arsenicosis. To collate the studies on medicinal plants and natural products with arsenic toxicity ameliorative effect, active pre-clinically and/or clinically. Literature survey was carried out by using Google, Scholar Google and Pub-Med. Only the scientific journal articles found on the internet for last two decades were considered. Minerals and semi-synthetic or synthetic analogs of natural products were excluded. Literature study revealed that 34 medicinal plants and 14 natural products exhibited significant protection from arsenic toxicity, mostly in preclinical trials and a few in clinical studies. This research could lead to development of a potentially useful agent in clinical management of arsenicosis in humans.

  15. Natural antifouling compound production by microbes associated with marine macroorganisms — A review

    Directory of Open Access Journals (Sweden)

    Sathianeson Satheesh

    2016-05-01

    Full Text Available In the marine environment, all hard surfaces including marine macroorganims are colonized by microorganisms mainly from the surrounding environment. The microorganisms associated with marine macroorganisms offer tremendous potential for exploitation of bioactive metabolites. Biofouling is a continuous problem in marine sectors which needs huge economy for control and cleaning processes. Biotechnological way for searching natural product antifouling compounds gained momentum in recent years because of the environmental pollution associated with the use of toxic chemicals to control biofouling. While, natural product based antifoulants from marine organisms particularly sponges and corals attained significance due to their activities in field assays, collection of larger amount of organisms from the sea is not a viable one. The microorganisms associated with sponges, corals, ascidians, seaweeds and seagrasses showed strong antimicrobial and also antifouling activities. This review highlights the advances in natural product antifoulants research from microbes associated with marine organisms.

  16. Fire Process Research Natural Areas: Managing research and restoration of dynamic ecosystem processes

    Science.gov (United States)

    Timothy Ingalsbee

    2001-01-01

    Since 1992 a collaborative group of fire scientists, forest conservationists, and Federal resource specialists have been developing proposals for a Research Natural Area (RNA) in the Warner Creek Fire area on the Willamette National Forest in Oregon. Inspired by these proposals, the Oregon Natural Heritage Plan created the new category of "Fire Process RNAs"...

  17. Political behavior in organizational context: nature, research and paradigm

    Directory of Open Access Journals (Sweden)

    Hasan Jafariani

    2012-09-01

    Full Text Available This paper investigates political behavior in organization context. In the first section, it studies inappropriate terminology in political behavior arena and recommends that political behaviors are neither positive nor negative in nature. The study also demonstrates that ends and means for influencing others are two criteria for determining faces of political behavior. In the second section, related and important research are reviewed and categorized in terms of content. Finally, we present the dominant paradigm of political behavior as a philosophical infrastructure. The study also presents some guidelines for further research the limitations are discussed in conclusion part.

  18. Liquefied natural gas (LNG) : production, storage and handling. 7. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Kalra, S; Jaron, K; Adragna, M; Coyle, S; Foley, C; Hawryn, S; Martin, A; McConnell, J [eds.

    2003-07-01

    This Canadian Standard on the production, storage and handling of liquefied natural gas (LNG) was prepared by the Technical Committee on Liquefied Natural Gas under the jurisdiction of the Steering Committee on Oil and Gas Industry Systems and Materials. It establishes the necessary requirements for the design, installation and safe operation of LNG facilities. The Standard applies to the design, location, construction, operation and maintenance of facilities at any location of the liquefaction of natural gas and for the storage, vaporization, transfer, handling and truck transport of LNG. The training of personnel involved is also included as well as containers for LNG storage, including insulated vacuum systems. It includes non-mandatory guidelines for small LNG facilities but does not apply to the transportation of refrigerants, LNG by rail, marine vessel or pipeline. This latest edition contains changes in working of seismic design requirements and minor editorial changes to several clauses to bring the Standard closer to the US National Fire Protection Association's Committee on Liquefied Natural Gas Standard while maintaining Canadian regulatory requirements. The document is divided into 12 sections including: general requirements; plant site provisions; process equipment; stationary LNG storage containers; vaporization facilities; piping system and components; instrumentation and electrical services; transfer of LNG and refrigerants; fire protection, safety and security; and, operating, maintenance and personnel training. This Standard, like all Canadian Standards, was subject to periodic review and was most recently reaffirmed in 2003. 6 tabs., 6 figs., 3 apps.

  19. Production of bio-synthetic natural gas in Canada.

    Science.gov (United States)

    Hacatoglu, Kevork; McLellan, P James; Layzell, David B

    2010-03-15

    Large-scale production of renewable synthetic natural gas from biomass (bioSNG) in Canada was assessed for its ability to mitigate energy security and climate change risks. The land area within 100 km of Canada's network of natural gas pipelines was estimated to be capable of producing 67-210 Mt of dry lignocellulosic biomass per year with minimal adverse impacts on food and fiber production. Biomass gasification and subsequent methanation and upgrading were estimated to yield 16,000-61,000 Mm(3) of pipeline-quality gas (equivalent to 16-63% of Canada's current gas use). Life-cycle greenhouse gas emissions of bioSNG-based electricity were calculated to be only 8.2-10% of the emissions from coal-fired power. Although predicted production costs ($17-21 GJ(-1)) were much higher than current energy prices, a value for low-carbon energy would narrow the price differential. A bioSNG sector could infuse Canada's rural economy with $41-130 billion of investments and create 410,000-1,300,000 jobs while developing a nation-wide low-carbon energy system.

  20. Natural Gas Reserves, Development and Production in Qatar

    International Nuclear Information System (INIS)

    Naji, Abi-Aad.

    1998-01-01

    Qatar entered the club of natural gas exporters in early 1997 when the first shipment of liquefied natural gas left the state for Japan. Qatar was helped by the discovery in 1971 of supergiant North Field gas field, the country's suitable location between the established gas consuming markets in Europe and Southeast Asia, and its proximity to developing markets in the Indian subcontinent and in neighbouring countries. All that have combined to make gas export projects from Qatar economically viable and commercially attractive. In addition to export-oriented development, increased gas production from the North Field is planned for meeting a growing domestic demand for gas as fuel and feedstock for power generation and desalination plants, as well as value-added petrochemical and fertilizer industries

  1. Leveraging ecological theory to guide natural product discovery.

    Science.gov (United States)

    Smanski, Michael J; Schlatter, Daniel C; Kinkel, Linda L

    2016-03-01

    Technological improvements have accelerated natural product (NP) discovery and engineering to the point that systematic genome mining for new molecules is on the horizon. NP biosynthetic potential is not equally distributed across organisms, environments, or microbial life histories, but instead is enriched in a number of prolific clades. Also, NPs are not equally abundant in nature; some are quite common and others markedly rare. Armed with this knowledge, random 'fishing expeditions' for new NPs are increasingly harder to justify. Understanding the ecological and evolutionary pressures that drive the non-uniform distribution of NP biosynthesis provides a rational framework for the targeted isolation of strains enriched in new NP potential. Additionally, ecological theory leads to testable hypotheses regarding the roles of NPs in shaping ecosystems. Here we review several recent strain prioritization practices and discuss the ecological and evolutionary underpinnings for each. Finally, we offer perspectives on leveraging microbial ecology and evolutionary biology for future NP discovery.

  2. Conceptual process synthesis for recovery of natural products from plants

    DEFF Research Database (Denmark)

    Malwade, Chandrakant R.; Qu, Haiyan; Rong, Ben-Guang

    2013-01-01

    ) and purification of target compound(s) from the crude extract. Process analytical technology (PAT) is used in each step to understand the nature of material systems and separation characteristics of each separation method. In the present work, this methodology is applied to generate process flow sheet for recovery......A systematic method of conceptual process synthesis for recovery of natural products from their biological sources is presented. This methodology divides the task into two major subtasks namely, isolation of target compound from a chemically complex solid matrix of biological source (crude extract...... in individual unit operations of maceration, flash column chromatography, and crystallization are 90.0%, 87.1, and 47.6%, respectively. Results showed that the crystallization step is dominant to the overall yield of the process which was 37.3%....

  3. Hydrogen research and development in Hawaii: Hawaii natural energy institute's hydrogen from renewable resources research program

    International Nuclear Information System (INIS)

    McKinley, K.R.; Rocheleau, R.E.; Takahashi, P.K.; Jensen, C.M.

    1993-01-01

    Hawaii, an energy-vulnerable state, has launched a Renewable Resources Research Program, focusing on hydrogen production and storage; the main tasks of this effort are: photoelectrochemical production of hydrogen through the use of coated silicon electrodes; solar conversion and the production of hydrogen with cyanobacteria; improved hydrogen storage through the use of nonclassical poly-hydride metal complexes. 10 refs

  4. Natural Products from Ethnodirected Studies: Revisiting the Ethnobiology of the Zombie Poison

    Science.gov (United States)

    Albuquerque, Ulysses Paulino; Melo, Joabe Gomes; Medeiros, Maria Franco; Menezes, Irwin Rose; Moura, Geraldo Jorge; Asfora El-Deir, Ana Carla; Alves, Rômulo Romeu; de Medeiros, Patrícia Muniz; de Sousa Araújo, Thiago Antonio; Alves Ramos, Marcelo; Silva, Rafael Ricardo; Almeida, Alyson Luiz; Almeida, Cecília de Fátima Castelo

    2012-01-01

    Wade Davis's study of Haitian “zombification” in the 1980s was a landmark in ethnobiological research. His research was an attempt to trace the origins of reports of “undead” Haitians, focusing on the preparation of the zombification poison. Starting with this influential ethnopharmacological research, this study examines advances in the pharmacology of natural products, focusing especially on those of animal-derived products. Ethnopharmacological, pharmacological, and chemical aspects are considered. We also update information on the animal species that reportedly constitute the zombie poison. Several components of the zombie powder are not unique to Haiti and are used as remedies in traditional medicine worldwide. This paper emphasizes the medicinal potential of products from zootherapy. These biological products are promising sources for the development of new drugs. PMID:21977054

  5. Water for wood products versus nature, food or feed

    Science.gov (United States)

    Schyns, Joep; Booij, Martijn; Hoekstra, Arjen

    2017-04-01

    more water available for the generation of other ecosystem services. Our findings contribute to a more complete picture of the human appropriation of water and the understanding of the interlinkages between the SDGs, thus feeding the debate on water for wood products versus nature, food or feed.

  6. A general enantioselective route to the chamigrene natural product family

    KAUST Repository

    White, David E.

    2010-06-01

    Described in this report is an enantioselective route toward the chamigrene natural product family. The key disconnections in our synthetic approach include sequential enantioselective decarboxylative allylation and ring-closing olefin metathesis to form the all-carbon quaternary stereocenter and spirocyclic core present in all members of this class of compounds. The generality of this strategy is demonstrated by the first total syntheses of elatol and the proposed structure of laurencenone B, as well as the first enantioselective total syntheses of laurencenone C and α-chamigrene. A brief exploration of the substrate scope of the enantioselective decarboxylative allylation/ring-closing metathesis sequence with fully substituted vinyl chlorides is also presented.

  7. Bioactive Natural Products of Marine Sponges from the Genus Hyrtios

    Directory of Open Access Journals (Sweden)

    Nourhan Hisham Shady

    2017-05-01

    Full Text Available Marine sponges are known as a rich source for novel bioactive compounds with valuable pharmacological potential. One of the most predominant sponge genera is Hyrtios, reported to have various species such as Hyrtios erectus, Hyrtios reticulatus, Hyrtios gumminae, Hyrtios communis, and Hyrtios tubulatus and a number of undescribed species. Members of the genus Hyrtios are a rich source of natural products with diverse and valuable biological activities, represented by different chemical classes including alkaloids, sesterterpenes and sesquiterpenes. This review covers the literature until June 2016, providing a complete survey of all compounds isolated from the genus Hyrtios with their corresponding biological activities whenever applicable.

  8. Natural product diversity of actinobacteria in the Atacama Desert.

    Science.gov (United States)

    Rateb, Mostafa E; Ebel, Rainer; Jaspars, Marcel

    2018-02-14

    The Atacama Desert of northern Chile is considered one of the most arid and extreme environment on Earth. Its core region was described as featuring "Mars-like" soils that were at one point deemed too extreme for life to exist. However, recent investigations confirmed the presence of diverse culturable actinobacteria. In the current review, we discuss a total of 46 natural products isolated to date representing diverse chemical classes characterized from different actinobacteria isolated from various locations in the Atacama Desert. Their reported biological activities are also discussed.

  9. Enantiospecific Synthesis of Trisubstituted Butyrolactone Natural Products and Their Analogs.

    Science.gov (United States)

    Sibi, Mukund P.; Lu, Jianliang; Talbacka, Chelsy L.

    1996-11-01

    A general methodology for the synthesis of highly substituted butyrolactones in enantiomerically pure form has been developed. The application of this process in a highly efficient synthesis of lactone natural products blastmycinone (1), NFX-2 (2), antimycinone (3), and NFX-4 (4) and two lipid metabolites (5, 6) are described. Additionally, the total synthesis of 5-epi-blastmycinone (22), 5-epi-NFX-2 (21b), 5-epi-NFX-4 (21c), and lipid metabolite analogs (19, 20) are also described. The overall yields for the target molecules are the highest reported so far in the literature.

  10. A general enantioselective route to the chamigrene natural product family

    KAUST Repository

    White, David E.; Stewart, Ian C.; Seashore-Ludlow, Brinton A.; Grubbs, Robert H.; Stoltz, Brian M.

    2010-01-01

    Described in this report is an enantioselective route toward the chamigrene natural product family. The key disconnections in our synthetic approach include sequential enantioselective decarboxylative allylation and ring-closing olefin metathesis to form the all-carbon quaternary stereocenter and spirocyclic core present in all members of this class of compounds. The generality of this strategy is demonstrated by the first total syntheses of elatol and the proposed structure of laurencenone B, as well as the first enantioselective total syntheses of laurencenone C and α-chamigrene. A brief exploration of the substrate scope of the enantioselective decarboxylative allylation/ring-closing metathesis sequence with fully substituted vinyl chlorides is also presented.

  11. Marine Vibrionaceae as a source of bioactive natural products

    DEFF Research Database (Denmark)

    Månsson, Maria; Wietz, Matthias; Gram, Lone

    an ecological function. Using chemical profiling, vibrio strains were compared on a global scale, revealing that the production of certain compounds is a conserved feature independent of sample locations. Chemical screening techniques such as explorative solid-phase extraction led to the isolation of two novel...... that some strains were capable of producing antibacterial compounds when grown on natural substrates such as chitin or seaweed. One Vibrio coralliilyticus strain was capable of producing the antibacterial compound when using chitin as the sole carbon source and in a live chitin model system, suggesting...... of which possess biological activities attractive for alternative strategies in antibacterial therapy....

  12. Natural product antifoulants from the octocorals of Indian waters

    Digital Repository Service at National Institute of Oceanography (India)

    Raveendran, T.V.; LimnaMol, V.P.; Parameswaran, P.S.

    stream_size 22497 stream_content_type text/plain stream_name Int_Biodeterior_Biodegrad_65_265a.pdf.txt stream_source_info Int_Biodeterior_Biodegrad_65_265a.pdf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8... 1 Author version: International Biodeterioration & Biodegradation, vol.65(1); 2011; 265-268 Natural Product Antifoulants from the Octocorals of Indian waters T.V. Raveendran * , V.P. Limna Mol, P.S. Parameswaran National Institute...

  13. The Canadian Natural Health Products (NHP) regulations: industry compliance motivations.

    Science.gov (United States)

    Laeeque, Hina; Boon, Heather; Kachan, Natasha; Cohen, Jillian Clare; D'Cruz, Joseph

    2007-06-01

    This qualitative study explores corporations' motivations to comply with new natural health products (NHP) Regulations in Canada. Interviews were conducted with representatives from 20 Canadian NHP companies. Findings show that the rationale for compliance differs for large compared to small and medium-sized enterprises (SMEs). Large firms are motivated to comply with the regulations because of the deterrent fear of negative media coverage, social motivations, ability to comply and maintaining a competitive market advantage. In contrast, SMEs are motivated to comply due to the deterrent fear of legal prosecution and a sense of duty.

  14. Environmental review of natural gas production in Lake Erie

    International Nuclear Information System (INIS)

    O'Shea, K.

    2002-01-01

    The water of Lake Erie is used as a source of drinking water for Ontario, New York, Pennsylvania, Ohio and Michigan. An environmental review has been conducted to determine the impact of drilling operations on the overall ecology of the lake. Since 1913, 2000 natural gas wells have been drilled in Lake Erie, of which 550 currently produce gas and account for 75 per cent of Ontario's total gas production. 180 wells are shut-in or suspended and the remaining wells have been abandoned. The gas wells are connected to onshore production facilities by approximately 1,600 km of small diameter pipelines that lie buried near shore or on top of the lake bed. Nearly 90 per cent of the in-lake infrastructure is in water depths of more than 20 metres. Talisman Energy is actively involved with the Canadian Coast Guard, the Department of Fisheries and Oceans, and the Ministry of Natural Resources to ensure cooperation between regulators and off-shore personnel. The environmental assessment of natural gas production in Lake Erie included a review of regulatory and best management practices, a biophysical overview of the lake, and a review of drilling practices, well completions, handling of waste streams, materials management, operations inspections, wastewater discharge, air emissions, and oil spills. It was revealed that for most drilling programs, cuttings are washed and discharged to the Lake. Ongoing testing will determine the impact that this practice has on benthic populations. The drill muds used for drilling operations are water based, environmentally friendly, and re-used between well locations. For completion programs, all well activities are closed circuit operations. Wells are abandoned through plugging with cement, removing wellheads and casing below the lake bottom. There has been a reported volume of about 23,000 litres of spilled product from 1990 to 2001, of which 68 per cent has come from 3 industrial companies that operate near Lake Erie. The offshore gas

  15. Discovery of the leinamycin family of natural products by mining actinobacterial genomes.

    Science.gov (United States)

    Pan, Guohui; Xu, Zhengren; Guo, Zhikai; Hindra; Ma, Ming; Yang, Dong; Zhou, Hao; Gansemans, Yannick; Zhu, Xiangcheng; Huang, Yong; Zhao, Li-Xing; Jiang, Yi; Cheng, Jinhua; Van Nieuwerburgh, Filip; Suh, Joo-Won; Duan, Yanwen; Shen, Ben

    2017-12-26

    Nature's ability to generate diverse natural products from simple building blocks has inspired combinatorial biosynthesis. The knowledge-based approach to combinatorial biosynthesis has allowed the production of designer analogs by rational metabolic pathway engineering. While successful, structural alterations are limited, with designer analogs often produced in compromised titers. The discovery-based approach to combinatorial biosynthesis complements the knowledge-based approach by exploring the vast combinatorial biosynthesis repertoire found in Nature. Here we showcase the discovery-based approach to combinatorial biosynthesis by targeting the domain of unknown function and cysteine lyase domain (DUF-SH) didomain, specific for sulfur incorporation from the leinamycin (LNM) biosynthetic machinery, to discover the LNM family of natural products. By mining bacterial genomes from public databases and the actinomycetes strain collection at The Scripps Research Institute, we discovered 49 potential producers that could be grouped into 18 distinct clades based on phylogenetic analysis of the DUF-SH didomains. Further analysis of the representative genomes from each of the clades identified 28 lnm -type gene clusters. Structural diversities encoded by the LNM-type biosynthetic machineries were predicted based on bioinformatics and confirmed by in vitro characterization of selected adenylation proteins and isolation and structural elucidation of the guangnanmycins and weishanmycins. These findings demonstrate the power of the discovery-based approach to combinatorial biosynthesis for natural product discovery and structural diversity and highlight Nature's rich biosynthetic repertoire. Comparative analysis of the LNM-type biosynthetic machineries provides outstanding opportunities to dissect Nature's biosynthetic strategies and apply these findings to combinatorial biosynthesis for natural product discovery and structural diversity.

  16. Researching Pacific island livelihoods: mobility, natural resource management and nissology.

    Science.gov (United States)

    Christensen, Andreas E; Mertz, Ole

    2010-01-01

    Small island literature is vast in focus and aim, and is rooted in many different disciplines. The challenge is to find common grounds for researching small islands conceptually and theoretically. The aim of this article is to comment on how to research small islands, including a discussion on contemporary theories of nissology and conceptual analytical frameworks for island research. Through a review of selected case-study-based island literature on changing livelihoods coming out of the South Pacific, we wish to illustrate and discuss advantages of finding common grounds for small island studies. The focus is on two dimensions of island livelihood, migration and natural resource management, both of which are significant contributors in making island livelihoods and shaping Pacific seascapes. We argue that there is still a substantial lack of studies targeting small island dynamics that are empirical and interdisciplinary in focus and link socio-economic and ecological processes of small island societies at temporal and analytical scales.

  17. Research into the transmission of natural gas by gas pipeline

    Energy Technology Data Exchange (ETDEWEB)

    Gadonneix, P.

    1998-12-31

    This paper is the press release of the talk given at the `Gaz de France scientific meeting with the press` by P. Gadonneix, chairman of Gaz de France company, on October 7, 1998. The aim of this talk concerns the new French and European supply link for bringing natural gas from the Norwegian North Sea fields. This new supply link is the first direct link between Norway and France and the NorFra gas pipeline which brings natural gas from the North Sea to France is the longest offshore pipeline in the world. The `Artere des Hauts de France` pipeline (the largest diameter gas pipeline ever laid in France) is devoted to the transfer of natural gas from Dunkerque to the Gournay-sur-Aronde underground storage site. This paper describes successively: the French European gas supply hub, the NorFra project, the Artere des Hauts de France pipeline, the network performance research, the safety and quality guaranties, the reduction of overland natural gas transmission costs (improvement of pipe-laying techniques and optimization of line route and welding operations), the specific techniques used for road and river crossing (micro-tunnel digging, river-crossing ditches) and for anchoring (buoyancy compensation). Finally, the environmental impact of the laying operations is briefly described. (J.S.)

  18. Personal-Care Products Formulated with Natural Antioxidant Extracts

    Directory of Open Access Journals (Sweden)

    Maria Luisa Soto

    2018-01-01

    Full Text Available The objective of this study was to evaluate the potential use of some vegetal raw materials in personal-care products. Four ethanolic extracts (grape pomace, Pinus pinaster wood chips, Acacia dealbata flowers, and Lentinus edodes were prepared and total phenolics, monomeric sugars, and antioxidant capacity were determined on alcoholic extracts. Six of the most important groups of cosmetics products (hand cream, body oil, shampoo, clay mask, body exfoliating cream, and skin cleanser were formulated. Participants evaluated some sensory attributes and overall acceptance by a 10-point scale; the results showed differences among age-intervals, but not between males and females. The results confirmed that all extracts presented characteristics appropriate for their use in cosmetic formulations and their good acceptability by consumers into all cosmetic products. Texture/appearance, spreadability, and skin feeling are important attributes among consumer expectations, but odor and color were the primary drivers and helped differentiate the natural extracts added into all personal-care products.

  19. US production of natural gas from tight reservoirs

    International Nuclear Information System (INIS)

    1993-01-01

    For the purposes of this report, tight gas reservoirs are defined as those that meet the Federal Energy Regulatory Commission's (FERC) definition of tight. They are generally characterized by an average reservoir rock permeability to gas of 0.1 millidarcy or less and, absent artificial stimulation of production, by production rates that do not exceed 5 barrels of oil per day and certain specified daily volumes of gas which increase with the depth of the reservoir. All of the statistics presented in this report pertain to wells that have been classified, from 1978 through 1991, as tight according to the FERC; i.e., they are ''legally tight'' reservoirs. Additional production from ''geologically tight'' reservoirs that have not been classified tight according to the FERC rules has been excluded. This category includes all producing wells drilled into legally designated tight gas reservoirs prior to 1978 and all producing wells drilled into physically tight gas reservoirs that have not been designated legally tight. Therefore, all gas production referenced herein is eligible for the Section 29 tax credit. Although the qualification period for the credit expired at the end of 1992, wells that were spudded (began to be drilled) between 1978 and May 1988, and from November 5, 1990, through year end 1992, are eligible for the tax credit for a subsequent period of 10 years. This report updates the EIA's tight gas production information through 1991 and considers further the history and effect on tight gas production of the Federal Government's regulatory and tax policy actions. It also provides some high points of the geologic background needed to understand the nature and location of low-permeability reservoirs

  20. Using Natural Products to Treat Resistant and Persistent Bacterial Infections

    Science.gov (United States)

    Deering, Robert W.

    Antimicrobial resistance is a growing threat to human health both worldwide and in the United States. Most concerning is the emergence of multi-drug resistant (MDR) bacterial pathogens, especially the 'ESKAPE' pathogens for which treatment options are dwindling. To complicate the problem, approvals of antibiotic drugs are extremely low and many research and development efforts in the pharmaceutical industry have ceased, leaving little certainty that critical new antibiotics are nearing the clinic. New antibiotics are needed to continue treating these evolving infections. In addition to antibiotics, approaches that aim to inhibit or prevent antimicrobial resistance could be useful. Also, studies that improve our understanding of bacterial pathophysiology could lead to new therapies for infectious disease. Natural products, especially those from the microbial world, have been invaluable as resources for new antibacterial compounds and as insights into bacterial physiology. The goal of this dissertation is to find new ways to treat resistant bacterial infections and learn more about the pathophysiology of these bacteria. Investigations of natural products to find molecules able to be used as new antibiotics or to modulate resistance and other parts of bacterial physiology are crucial aspects of the included studies. The first included study, which is reported in chapter two, details a chemical investigation of a marine Pseudoalteromonas sp. Purification efforts of the microbial metabolites were guided by testing against a resistance nodulation of cell division model of efflux pumps expressed in E. coli. These pumps play an important role in the resistance of MDR Gram negative pathogens such as Pseudomonas aeruginosa and Enterobacteriaceae. Through this process, 3,4-dibromopyrrole-2,5-dione was identified as a potent inhibitor of the RND efflux pumps and showed synergistic effects against the E. coli strain with common antibiotics including fluoroquinolones, beta

  1. Total Synthesis of Natural Products Using Hypervalent Iodine Reagents

    Directory of Open Access Journals (Sweden)

    Gaetan eMaertens

    2015-01-01

    Full Text Available We present a review of natural product syntheses accomplished in our laboratory during the last five years. Each synthetic route features a phenol dearomatization promoted by an environmentally benign hypervalent iodine reagent. The dearomatizations demonstrate the aromatic ring umpolung concept, and involve stereoselective remodeling of the inert unsaturations of a phenol into a highly functionalized key intermediate that may contain a quaternary carbon center and a prochiral dienone system. Several new oxidative strategies were employed, including transpositions (1,3-alkyl shift and Prins-pinacol, a polycyclization, an ipso rearrangement, and direct nucleophilic additions at the phenol para position. Several alkaloids, heterocyclic compounds, and a polycyclic core have been achieved, including sceletenone (a serotonin reuptake inhibitor, acetylaspidoalbidine (an antitumor agent, fortucine (antiviral and antitumor, erysotramidine (curare-like effect, platensimycin (an antibiotic, and the main core of a kaurane diterpene (immunosuppressive agent and stimulator of apoptosis. These concise and in some cases enantioselective syntheses effectively demonstrate the importance of hypervalent iodine reagents in the total synthesis of bioactive natural products.

  2. A diversity oriented synthesis of natural product inspired molecular libraries.

    Science.gov (United States)

    Chauhan, Jyoti; Luthra, Tania; Gundla, Rambabu; Ferraro, Antonio; Holzgrabe, Ulrike; Sen, Subhabrata

    2017-11-07

    Natural products are the source of innumerable pharmaceutical drug candidates and also form an important aspect of herbal remedies. They are also a source of various bioactive compounds. Herein we have leveraged the structural attributes of several natural products in building a library of architecturally diverse chiral molecules by harnessing R-tryptophan as the chiral auxiliary. It is converted to its corresponding methyl ester 1 which in turn provided a bevy of 1-aryl-tetrahydro-β-carbolines 2a-d, which were then converted to chiral compounds via a diversity oriented synthetic strategy (DOS). In general, intermolecular and intramolecular ring rearrangements facilitated the formation of the final compounds. Four different classes of molecules with distinct architectures were generated, adding up to nearly twenty-two individual molecules. Phenotypic screening of a representative section of the library revealed two molecules that selectively inhibit MCF7 breast cancer cells with IC 50 of ∼5 μg mL -1 potency.

  3. Applications of natural zeolites on agriculture and food production.

    Science.gov (United States)

    Eroglu, Nazife; Emekci, Mevlut; Athanassiou, Christos G

    2017-08-01

    Zeolites are crystalline hydrated aluminosilicates with remarkable physical and chemical properties, which include losing and receiving water in a reverse way, adsorbing molecules that act as molecular sieves, and replacing their constituent cations without structural change. The commercial production of natural zeolites has accelerated during the last 50 years. The Structure Commission of the International Zeolite Association recorded more than 200 zeolites, which currently include more than 40 naturally occurring zeolites. Recent findings have supported their role in stored-pest management as inert dust applications, pesticide and fertilizer carriers, soil amendments, animal feed additives, mycotoxin binders and food packaging materials. There are many advantages of inert dust application, including low cost, non-neurotoxic action, low mammalian toxicity and safety for human consumption. The latest consumer trends and government protocols have shifted toward organic origin materials to replace synthetic chemical products. In the present review, we summarize most of the main uses of zeolites in food and agruculture, along with the with specific paradigms that illustrate their important role. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  4. The potential of natural products for targeting PPARα

    Directory of Open Access Journals (Sweden)

    Daniela Rigano

    2017-07-01

    Full Text Available Peroxisome proliferator activated receptors (PPARs α, -γ and -β/δ are ligand-activated transcription factors and members of the superfamily of nuclear hormone receptor. These receptors play key roles in maintaining glucose and lipid homeostasis by modulating gene expression. PPARs constitute a recognized druggable target and indeed several classes of drugs used in the treatment of metabolic disease symptoms, such as dyslipidemia (fibrates, e.g. fenofibrate and gemfibrozil and diabetes (thiazolidinediones, e.g. rosiglitazone and pioglitazone are ligands for the various PPAR isoforms. More precisely, antidiabetic thiazolidinediones act on PPARγ, while PPARα is the main molecular target of antidyslipidemic fibrates. Over the past few years, our understanding of the mechanism underlying the PPAR modulation of gene expression has greatly increased. This review presents a survey on terrestrial and marine natural products modulating the PPARα system with the objective of highlighting how the incredible chemodiversity of natural products can provide innovative leads for this “hot” target.

  5. Experience curve for natural gas production by hydraulic fracturing

    International Nuclear Information System (INIS)

    Fukui, Rokuhei; Greenfield, Carl; Pogue, Katie; Zwaan, Bob van der

    2017-01-01

    From 2007 to 2012 shale gas production in the US expanded at an astounding average growth rate of over 50%/yr, and thereby increased nearly tenfold over this short time period alone. Hydraulic fracturing technology, or “fracking”, as well as new directional drilling techniques, played key roles in this shale gas revolution, by allowing for extraction of natural gas from previously unviable shale resources. Although hydraulic fracturing technology had been around for decades, it only recently became commercially attractive for large-scale implementation. As the production of shale gas rapidly increased in the US over the past decade, the wellhead price of natural gas dropped substantially. In this paper we express the relationship between wellhead price and cumulative natural gas output in terms of an experience curve, and obtain a learning rate of 13% for the industry using hydraulic fracturing technology. This learning rate represents a measure for the know-how and skills accumulated thus far by the US shale gas industry. The use of experience curves for renewable energy options such as solar and wind power has allowed analysts, practitioners, and policy makers to assess potential price reductions, and underlying cost decreases, for these technologies in the future. The reasons for price reductions of hydraulic fracturing are fundamentally different from those behind renewable energy technologies – hence they cannot be directly compared – and hydraulic fracturing may soon reach, or maybe has already attained, a lower bound for further price reductions, for instance as a result of its water requirements or environmental footprint. Yet, understanding learning-by-doing phenomena as expressed by an industry-wide experience curve for shale gas production can be useful for strategic planning in the gas sector, as well as assist environmental policy design, and serve more broadly as input for projections of energy system developments. - Highlights: • Hydraulic

  6. Natural radioactivity product from coal burning in PLTU Pacitan

    International Nuclear Information System (INIS)

    Sukirno; Sri Murniasih; Rosidi; Sutanto WW

    2016-01-01

    Monitoring of radioactivity in the coal-fired power plant has been carried out in the CAST-NAA laboratory at 2015. Monitoring includes analysis of soil, water, fly ash, bottom ash and coal. The basic purpose of this work is the investigation of natural radionuclide contents in coal and the actual product samples in the Pacitan power plant as a first step to estimate the radioactive in the vicinity. This paper presents the results of the analysis of radioactivity in samples of coal, fly ash and bottom ash as well as environment samples of soil and water. Ra-226, Th-232, K-40, U-235, U-238, and Pb-210 Natural radionuclides are determined by gamma spectrometry with HPGe detector. Natural radionuclide in fine grain coal, bottom ash and fly ash have concentrations range (162.182 to 0.057) Bq/kg. Radioactivity contained in soil ranges (0.041 to 169.34) Bq/kg, whereas in water ranges (0.003 to 0.045) Bq/L. According Perka BAPETEN. No. 7 of 2013. On Boundary Value Environmental Radioactivity, the results of measurement analysis contained water around the power plant Pacitan still below the limit values allowed by BAPETEN. (author)

  7. Using of Natural Language Processing Techniques in Suicide Research

    Directory of Open Access Journals (Sweden)

    Azam Orooji

    2017-09-01

    Full Text Available It is estimated that each year many people, most of whom are teenagers and young adults die by suicide worldwide. Suicide receives special attention with many countries developing national strategies for prevention. Since, more medical information is available in text, Preventing the growing trend of suicide in communities requires analyzing various textual resources, such as patient records, information on the web or questionnaires. For this purpose, this study systematically reviews recent studies related to the use of natural language processing techniques in the area of people’s health who have completed suicide or are at risk. After electronically searching for the PubMed and ScienceDirect databases and studying articles by two reviewers, 21 articles matched the inclusion criteria. This study revealed that, if a suitable data set is available, natural language processing techniques are well suited for various types of suicide related research.

  8. Lichen Symbiosis: Nature's High Yielding Machines for Induced Hydrogen Production

    Science.gov (United States)

    Papazi, Aikaterini; Kastanaki, Elizabeth; Pirintsos, Stergios; Kotzabasis, Kiriakos

    2015-01-01

    Hydrogen is a promising future energy source. Although the ability of green algae to produce hydrogen has long been recognized (since 1939) and several biotechnological applications have been attempted, the greatest obstacle, being the O2-sensitivity of the hydrogenase enzyme, has not yet been overcome. In the present contribution, 75 years after the first report on algal hydrogen production, taking advantage of a natural mechanism of oxygen balance, we demonstrate high hydrogen yields by lichens. Lichens have been selected as the ideal organisms in nature for hydrogen production, since they consist of a mycobiont and a photobiont in symbiosis. It has been hypothesized that the mycobiont’s and photobiont’s consumption of oxygen (increase of COX and AOX proteins of mitochondrial respiratory pathways and PTOX protein of chrolorespiration) establishes the required anoxic conditions for the activation of the phycobiont’s hydrogenase in a closed system. Our results clearly supported the above hypothesis, showing that lichens have the ability to activate appropriate bioenergetic pathways depending on the specific incubation conditions. Under light conditions, they successfully use the PSII-dependent and the PSII-independent pathways (decrease of D1 protein and parallel increase of PSaA protein) to transfer electrons to hydrogenase, while under dark conditions, lichens use the PFOR enzyme and the dark fermentative pathway to supply electrons to hydrogenase. These advantages of lichen symbiosis in combination with their ability to survive in extreme environments (while in a dry state) constitute them as unique and valuable hydrogen producing natural factories and pave the way for future biotechnological applications. PMID:25826211

  9. Lichen symbiosis: nature's high yielding machines for induced hydrogen production.

    Directory of Open Access Journals (Sweden)

    Aikaterini Papazi

    Full Text Available Hydrogen is a promising future energy source. Although the ability of green algae to produce hydrogen has long been recognized (since 1939 and several biotechnological applications have been attempted, the greatest obstacle, being the O2-sensitivity of the hydrogenase enzyme, has not yet been overcome. In the present contribution, 75 years after the first report on algal hydrogen production, taking advantage of a natural mechanism of oxygen balance, we demonstrate high hydrogen yields by lichens. Lichens have been selected as the ideal organisms in nature for hydrogen production, since they consist of a mycobiont and a photobiont in symbiosis. It has been hypothesized that the mycobiont's and photobiont's consumption of oxygen (increase of COX and AOX proteins of mitochondrial respiratory pathways and PTOX protein of chrolorespiration establishes the required anoxic conditions for the activation of the phycobiont's hydrogenase in a closed system. Our results clearly supported the above hypothesis, showing that lichens have the ability to activate appropriate bioenergetic pathways depending on the specific incubation conditions. Under light conditions, they successfully use the PSII-dependent and the PSII-independent pathways (decrease of D1 protein and parallel increase of PSaA protein to transfer electrons to hydrogenase, while under dark conditions, lichens use the PFOR enzyme and the dark fermentative pathway to supply electrons to hydrogenase. These advantages of lichen symbiosis in combination with their ability to survive in extreme environments (while in a dry state constitute them as unique and valuable hydrogen producing natural factories and pave the way for future biotechnological applications.

  10. Vegetable soybean: seed composition and production research

    Directory of Open Access Journals (Sweden)

    Qiuying Zhang

    2017-10-01

    Full Text Available Vegetable soybean (edamame [Glycine max (L. Merr.] is a low input, high nutritional value, short crop cycle and soil-enriching profitable crop. It offers quick economic return and provides health benefits to the consumers. The market demand for edamame has begun to flourish and expand dramatically in recent decades due to increased awareness of nutritional properties, and the change in life styles towards healthier food. This article highlighted the importance of edamame as a nutraceutical and functional food-grade produce, summarised the research advances in seed composition and their roles, cultivar selection and crop establishment, planting date and fertilisation, weed management and harvesting. Current production problem of extensive labor at harvest and future research challenges in improving crop establishment, developing cultivars competitive to weed and resistant to pest insects/diseases, assessing biological activities of edamame elemental and phytochemical properties on cancer cell inhibition, and developing organic production system were also proposed with aims of enhancing farm profitability and expanding opportunities for extensive use of edamame.

  11. China's natural gas: Resources, production and its impacts

    International Nuclear Information System (INIS)

    Wang, Jianliang; Feng, Lianyong; Zhao, Lin; Snowden, Simon

    2013-01-01

    In order to achieve energy consumption targets, and subsequently reduce carbon emissions, China is working on energy strategies and policies aimed at actively increasing the consumption of natural gas—the lowest carbon energy of the fossil fuels, and to enhance the proportion of gas in total primary energy consumption. To do this, it is a necessary prerequisite that China must have access to adequate gas resources and production to meet demand. This paper shows that the availability of domestic gas resources are overestimated by China's authorities due to differences in classification and definitions of gas resources/reserves between China and those accepted internationally. Based on official gas resource figures, China's gas production remains low with respect to the projected demand, and will only be 164.6 bcm in 2020, far lower than the 375 bcm of forecast demand. The gap between gas production and demand will reach 210.4 bcm by 2020. Existing plans for the importation of gas and the development of unconventional gas will not close this gap in the next 10 years, and this situation will therefore present a severe challenge to China's gas security, achievement of targets in improving energy consumption structure and reducing carbon emissions. - Highlights: ► We show that available gas resources are overestimated by China's authorities. ► We forecast China's future gas production under different resource scenarios. ► This paper shows that China's gas production will not meet the soaring demand. ► The gap between supply and demand will continue to increase rapidly in future. ► China's gas security will meet a severe challenge because of this increasing gap

  12. Natural Occurrence of Aldol Condensation Products in Valencia Orange Oil.

    Science.gov (United States)

    Abreu, Ingo; Da Costa, Neil C; van Es, Alfred; Kim, Jung-A; Parasar, Uma; Poulsen, Mauricio L

    2017-12-01

    Cold pressed orange oils contain predominantly d-limonene (approximately 95%) and various other lower concentration monoterpenes, sesquiterpenes, sinensals plus 3 key aliphatic aldehydes: hexanal, octanal. and decanal. The aldol self-condensation products or "dimers" for each aldehyde have been postulated as being present at low concentrations in the oil. However, to date only the hexanal dimer has been previously reported. In this paper, cold pressed Valencia orange oil was fractionally distilled/folded and analyzed by GC and high resolution GC-MS to detect these compounds on 2 different capillary column phases. Subsequently the hexanal, octanal, and decanal self-aldol condensation products, 2-butyl-2-octenal, 2-hexyl-2-decenal, and 2-octyl-2-dodecenal, respectively, were detected in the folded oil. These predominantly trans configuration isomeric compounds were synthesized, to confirm them as being present in nature and evaluated organoleptically by a panel of evaluators. To further confirm the mechanism of their formation, the enriched oil was made into a simple beverage to show the effect on the formation of these aldol compounds under acidic conditions. Finally aliphatic aldehydes from hexanal to undecanal were reacted together in various combinatorial pairs to give an additional 33 self and mixed aldol condensation products, some of which were also detected in the folded oil. This paper discloses the structural elucidation and synthesis of 8 novel aldol condensation products found at trace concentrations in citrus and leading to a further 31 mass spectrally determined aldol products. Sensory evaluations and application of some of these components were demonstrated in a model citrus beverage. © 2017 Institute of Food Technologists®.

  13. Rapeseed research and production in China

    Directory of Open Access Journals (Sweden)

    Qiong Hu

    2017-04-01

    Full Text Available Rapeseed (Brassica napus L. is the largest oilseed crop in China and accounts for about 20% of world production. For the last 10 years, the production, planting area, and yield of rapeseed have been stable, with improvement of seed quality and especially seed oil content. China is among the leading countries in rapeseed genomic research internationally, having jointly with other countries accomplished the whole genome sequencing of rapeseed and its two parental species, Brassica oleracea and Brassica rapa. Progress on functional genomics including the identification of QTL governing important agronomic traits such as yield, seed oil content, fertility regulation, disease and insect resistance, abiotic stress, nutrition use efficiency, and pod shattering resistance has been achieved. As a consequence, molecular markers have been developed and used in breeding programs. During 2005–2014, 215 rapeseed varieties were registered nationally, including 210 winter- and 5 spring-type varieties. Mechanization across the whole process of rapeseed production was investigated and operating instructions for all relevant techniques were published. Modern techniques for rapeseed field management such as high-density planting, controlled-release fertilizer, and biocontrol of disease and pests combined with precision tools such as drones have been developed and are being adopted in China. With the application of advanced breeding and production technologies, in the near future, the oil yield and quality of rapeseed varieties will be greatly increased, and more varieties with desirable traits, especially early maturation, high yield, high resistance to biotic and abiotic stress, and suitability for mechanized harvesting will be developed. Application of modern technologies on the mechanized management of rapeseed will greatly increase grower profit.

  14. Cholesterol overload impairing cerebellar function: the promise of natural products.

    Science.gov (United States)

    El-Sayyad, Hassan I H

    2015-05-01

    The cerebellum is the part of the brain most involved in controlling motor and cognitive function. The surface becomes convoluted, forming folia that have a characteristic internal structure of three layers including molecular, Purkinje cell, and granular layer. This complex neural network gives rise to a massive signal-processing capability. Cholesterol is a major constituent, derived by de novo synthesis and the blood-brain barrier. Cholesterol is tightly regulated between neurons and glia-that is, astrocytes, microglia, and oligodendrocytes-and is essential for normal brain development. The axon is wrapped by myelin (cholesterol, phospholipids, and glycosphingolipids) and made up of membranes of oligodendrocytes, separated by periodic gaps in the myelin sheath, called nodes of Ranvier. Hypercholesterolemia is associated with increased oxidative stress and the development of neurotoxicity and Alzheimer's disease. Treatment with natural products has been found to support improved brain function and reduce low-density-lipoprotein cholesterol level. Fish oil is one such product; among the many plant products are: Morus alba leaves, fruit, and bark; pomegranate fruit and peel; Barley β - glucans; date palm; and Allium sativum. The therapeutic potential was discussed in relation with the antilipidemic drugs, statins (HMG-CoA reductase inhibitors). Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Does Osmotic Stress Affect Natural Product Expression in Fungi?

    Science.gov (United States)

    Overy, David; Correa, Hebelin; Roullier, Catherine; Chi, Wei-Chiung; Pang, Ka-Lai; Rateb, Mostafa; Ebel, Rainer; Shang, Zhuo; Capon, Rob; Bills, Gerald; Kerr, Russell

    2017-08-13

    The discovery of new natural products from fungi isolated from the marine environment has increased dramatically over the last few decades, leading to the identification of over 1000 new metabolites. However, most of the reported marine-derived species appear to be terrestrial in origin yet at the same time, facultatively halo- or osmotolerant. An unanswered question regarding the apparent chemical productivity of marine-derived fungi is whether the common practice of fermenting strains in seawater contributes to enhanced secondary metabolism? To answer this question, a terrestrial isolate of Aspergillus aculeatus was fermented in osmotic and saline stress conditions in parallel across multiple sites. The ex-type strain of A. aculeatus was obtained from three different culture collections. Site-to-site variations in metabolite expression were observed, suggesting that subculturing of the same strain and subtle variations in experimental protocols can have pronounced effects upon metabolite expression. Replicated experiments at individual sites indicated that secondary metabolite production was divergent between osmotic and saline treatments. Titers of some metabolites increased or decreased in response to increasing osmolite (salt or glycerol) concentrations. Furthermore, in some cases, the expression of some secondary metabolites in relation to osmotic and saline stress was attributed to specific sources of the ex-type strains.

  16. Rational synthetic pathway refactoring of natural products biosynthesis in actinobacteria.

    Science.gov (United States)

    Tan, Gao-Yi; Liu, Tiangang

    2017-01-01

    Natural products (NPs) and their derivatives are widely used as frontline treatments for many diseases. Actinobacteria spp. are used to produce most of NP antibiotics and have also been intensively investigated for NP production, derivatization, and discovery. However, due to the complicated transcriptional and metabolic regulation of NP biosynthesis in Actinobacteria, especially in the cases of genome mining and heterologous expression, it is often difficult to rationally and systematically engineer synthetic pathways to maximize biosynthetic efficiency. With the emergence of new tools and methods in metabolic engineering, the synthetic pathways of many chemicals, such as fatty acids and biofuels, in model organisms (e.g. Escherichia coli ), have been refactored to realize precise and flexible control of production. These studies also offer a promising approach for synthetic pathway refactoring in Actinobacteria. In this review, the great potential of Actinobacteria as a microbial cell factory for biosynthesis of NPs is discussed. To this end, recent progress in metabolic engineering of NP synthetic pathways in Actinobacteria are summarized and strategies and perspectives to rationally and systematically refactor synthetic pathways in Actinobacteria are highlighted. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  17. Matrix Metalloproteinase Inhibitors (MMPIs from Marine Natural Products: the Current Situation and Future Prospects

    Directory of Open Access Journals (Sweden)

    Se-Kwon Kim

    2009-03-01

    Full Text Available Matrix metalloproteinases (MMPs are a family of more than twenty five secreted and membrane-bound zinc-endopeptidases which can degrade extracellular matrix (ECM components. They also play important roles in a variety of biological and pathological processes. Matrix metalloproteinase inhibitors (MMPIs have been identified as potential therapeutic candidates for metastasis, arthritis, chronic inflammation and wrinkle formation. Up to present, more than 20,000 new compounds have been isolated from marine organisms, where considerable numbers of these naturally occurring derivatives are developed as potential candidates for pharmaceutical application. Eventhough the quantity of marine derived MMPIs is less when compare with the MMPIs derived from terrestrial materials, huge potential for bioactivity of these marine derived MMPIs has lead to large number of researches. Saccharoids, flavonoids and polyphones, fatty acids are the most important groups of MMPIs derived from marine natural products. In this review we focus on the progress of MMPIs from marine natural products.

  18. Natural sweetening of food products by engineering Lactococcus lactis for glucose production

    NARCIS (Netherlands)

    Pool, Wietske A.; Neves, Ana Rute; Kok, Jan; Santos, Helena; Kuipers, Oscar P.

    We show that sweetening of food products by natural fermentation can be achieved by a combined metabolic engineering and transcriptome analysis approach. A Lactococcus lactis ssp. cremoris strain was constructed in which glucose metabolism was completely disrupted by deletion of the genes coding for

  19. Lightweight Approaches to Natural Gas Hydrate Exploration & Production

    Science.gov (United States)

    Max, M. D.; Johnson, A. H.

    2017-12-01

    Lower-cost approaches to drilling and reservoir utilization are made possible by adapting both emerging and new technology to the unique, low risk NGH natural gas resource. We have focused on drilling, wellbore lining technology, and reservoir management with an emphasis on long-term sand control and adaptive mechanical stability during NGH conversion to its constituent gas and water. In addition, we suggest that there are opportunities for management of both the gas and water with respect to maintaining desired thermal conditions. Some of the unique aspects of NGH deposits allow for new, more efficient technology to be applied to development, particularly in drilling. While NGH-bearing sands are in deepwater, they are confined to depths beneath the seafloor of 1.2 kilometers or less. As a result, they will not be significantly above hydrostatic pressure, and temperatures will be less than 30 oC. Drilling will be through semi-consolidated sediment without liquid hydrocarbons. These characteristics mean that high capability drillships are not needed. What is needed is a new perspective about drilling and producing NGH. Drilling from the seafloor will resolve the high-pressure differential between a wellhead on the sea surface in a vessel and reservoir to about the hydrostatic pressure difference between the seafloor and, at most, the base of the GHSZ. Although NGH production will begin using "off-the-shelf" technology, innovation will lead to new technology that will bring down costs and increase efficiency in the same way that led to the shale breakthrough. Commercial success is possible if consideration is given to what is actually needed to produce NGH in a safe and environmentally manner. Max, M.D. 2017. Wellbore Lining for Natural Gas Hydrate. U.S. Patent Application US15644947 Max, M.D. & Johnson, A.H. 2017. E&P Cost Reduction Opportunities for Natural Gas Hydrate. OilPro. . Max, M.D. & Johnson, A.H. 2016. Exploration and Production of Oceanic Natural Gas

  20. Evaluation of PHI Hunter in Natural Language Processing Research.

    Science.gov (United States)

    Redd, Andrew; Pickard, Steve; Meystre, Stephane; Scehnet, Jeffrey; Bolton, Dan; Heavirland, Julia; Weaver, Allison Lynn; Hope, Carol; Garvin, Jennifer Hornung

    2015-01-01

    We introduce and evaluate a new, easily accessible tool using a common statistical analysis and business analytics software suite, SAS, which can be programmed to remove specific protected health information (PHI) from a text document. Removal of PHI is important because the quantity of text documents used for research with natural language processing (NLP) is increasing. When using existing data for research, an investigator must remove all PHI not needed for the research to comply with human subjects' right to privacy. This process is similar, but not identical, to de-identification of a given set of documents. PHI Hunter removes PHI from free-form text. It is a set of rules to identify and remove patterns in text. PHI Hunter was applied to 473 Department of Veterans Affairs (VA) text documents randomly drawn from a research corpus stored as unstructured text in VA files. PHI Hunter performed well with PHI in the form of identification numbers such as Social Security numbers, phone numbers, and medical record numbers. The most commonly missed PHI items were names and locations. Incorrect removal of information occurred with text that looked like identification numbers. PHI Hunter fills a niche role that is related to but not equal to the role of de-identification tools. It gives research staff a tool to reasonably increase patient privacy. It performs well for highly sensitive PHI categories that are rarely used in research, but still shows possible areas for improvement. More development for patterns of text and linked demographic tables from electronic health records (EHRs) would improve the program so that more precise identifiable information can be removed. PHI Hunter is an accessible tool that can flexibly remove PHI not needed for research. If it can be tailored to the specific data set via linked demographic tables, its performance will improve in each new document set.

  1. Biocombinatorial Engineering of Fungal PKS-NRPS Hybrids for Production of Novel Synthetic Natural Products

    DEFF Research Database (Denmark)

    Nielsen, Maria Lund

    encoding a PKS-NRPS hybrid responsible for the production of a medically relevant compound in Talaromyces atroroseus. To the best of my knowledge, this study represents the first example of reverse engineering of a Talaromyces species. In the fourth study (chapter 5), I used the CRISPR-Cas9 system...... structure optimization. Within the last decade, an alternative approach for expanding natural product chemodiversity has been applied. This strategy, known as combinatorial biosynthesis, involves the re-engineering of biosynthetic pathways and ultimately the rational engineering of new natural product...... analogs. This field, however, has proved very challenging and many engineering efforts have resulted in enzymatic loss-of-function or reduced yields. Thus, the future success in combinatorial biosynthetic studies requires a thorough understanding of the structure and function of biosynthetic enzymes...

  2. Inhibitors of Microglial Neurotoxicity: Focus on Natural Products

    Directory of Open Access Journals (Sweden)

    Kyoungho Suk

    2011-01-01

    Full Text Available Microglial cells play a dual role in the central nervous system as they have both neurotoxic and neuroprotective effects. Uncontrolled and excessive activation of microglia often contributes to inflammation-mediated neurodegeneration. Recently, much attention has been paid to therapeutic strategies aimed at inhibiting neurotoxic microglial activation. Pharmacological inhibitors of microglial activation are emerging as a result of such endeavors. In this review, natural products-based inhibitors of microglial activation will be reviewed. Potential neuroprotective activity of these compounds will also be discussed. Future works should focus on the discovery of novel drug targets that specifically mediate microglial neurotoxicity rather than neuroprotection. Development of new drugs based on these targets may require a better understanding of microglial biology and neuroinflammation at the molecular, cellular, and systems levels.

  3. The Complexity of Bioactive Natural Products in Plants

    DEFF Research Database (Denmark)

    Frisch, Tina

    Plants produce a diverse range of bioactive natural products promoting their fitness. These specialized metabolites may serve as chemical defence against herbivores and pathogens and may inhibit the growth and development of competing species. Hydroxynitrile glucosides and glucosinolates are two...... classes of defence compounds, which have diverging properties, but also share common biosynthetic features. Hydroxynitrile glucosides are produced in species across the plant kingdom, whereas glucosinolates are found almost exclusively within the Brassicales, which generally does not contain...... hydroxynitrile glucosides. This division has raised questions regarding possible evolutionary relationships between the biosynthetic pathways. The very rare co-occurrence of hydroxynitrile glucosides and glucosinolates found in Alliaria petiolata (garlic mustard, løgkarse) and Carica papaya (papaya) makes...

  4. Role of Antioxidants and Natural Products in Inflammation

    Directory of Open Access Journals (Sweden)

    Palanisamy Arulselvan

    2016-01-01

    Full Text Available Inflammation is a comprehensive array of physiological response to a foreign organism, including human pathogens, dust particles, and viruses. Inflammations are mainly divided into acute and chronic inflammation depending on various inflammatory processes and cellular mechanisms. Recent investigations have clarified that inflammation is a major factor for the progression of various chronic diseases/disorders, including diabetes, cancer, cardiovascular diseases, eye disorders, arthritis, obesity, autoimmune diseases, and inflammatory bowel disease. Free radical productions from different biological and environmental sources are due to an imbalance of natural antioxidants which further leads to various inflammatory associated diseases. In this review article, we have outlined the inflammatory process and its cellular mechanisms involved in the progression of various chronic modern human diseases. In addition, we have discussed the role of free radicals-induced tissue damage, antioxidant defence, and molecular mechanisms in chronic inflammatory diseases/disorders. The systematic knowledge regarding the role of inflammation and its associated adverse effects can provide a clear understanding in the development of innovative therapeutic targets from natural sources that are intended for suppression of various chronic inflammations associated diseases.

  5. Aminobenzoates as building blocks for natural product assembly lines.

    Science.gov (United States)

    Walsh, Christopher T; Haynes, Stuart W; Ames, Brian D

    2012-01-01

    The ortho-, meta-, and para- regioisomers of aminobenzoate are building blocks for a wide range of microbial natural products. Both the ortho-isomer (anthranilate) and PABA derive from the central shikimate pathway metabolite chorismate while the meta-isomer is not available by that route and starts from UDP-3-aminoglucose. PABA is largely funnelled into folate biosynthesis while anthranilate is the scaffold for biosynthetic elaboration into many natural heterocycles, most notably with its role in indole formation for tryptophan biosynthesis. Anthranilate is also converted to benzodiazepinones, fumiquinazolines, quinoxalines, phenoxazines, benzoxazolinates, quinolones, and phenazines, often with redox enzyme participation. The 5-hydroxy form of 3-aminobenzaote is the starter unit for ansa-bridged rifamycins, ansamitocins, and geldanamycins, whereas regioisomers 2-hydroxy, 4-hydroxy and 2,4-dihydroxy-3-aminobenzoate are key components of antimycin, grixazone, and platencin and platensimycin biosynthesis, respectively. The enzymatic mechanisms for generation of the aminobenzoate regioisomers and their subsequent utilization for diverse heterocycle and macrocycle construction are examined.

  6. Quantifying methane emissions from natural gas production in north-eastern Pennsylvania

    Directory of Open Access Journals (Sweden)

    Z. R. Barkley

    2017-11-01

    Full Text Available Natural gas infrastructure releases methane (CH4, a potent greenhouse gas, into the atmosphere. The estimated emission rate associated with the production and transportation of natural gas is uncertain, hindering our understanding of its greenhouse footprint. This study presents a new application of inverse methodology for estimating regional emission rates from natural gas production and gathering facilities in north-eastern Pennsylvania. An inventory of CH4 emissions was compiled for major sources in Pennsylvania. This inventory served as input emission data for the Weather Research and Forecasting model with chemistry enabled (WRF-Chem, and atmospheric CH4 mole fraction fields were generated at 3 km resolution. Simulated atmospheric CH4 enhancements from WRF-Chem were compared to observations obtained from a 3-week flight campaign in May 2015. Modelled enhancements from sources not associated with upstream natural gas processes were assumed constant and known and therefore removed from the optimization procedure, creating a set of observed enhancements from natural gas only. Simulated emission rates from unconventional production were then adjusted to minimize the mismatch between aircraft observations and model-simulated mole fractions for 10 flights. To evaluate the method, an aircraft mass balance calculation was performed for four flights where conditions permitted its use. Using the model optimization approach, the weighted mean emission rate from unconventional natural gas production and gathering facilities in north-eastern Pennsylvania approach is found to be 0.36 % of total gas production, with a 2σ confidence interval between 0.27 and 0.45 % of production. Similarly, the mean emission estimates using the aircraft mass balance approach are calculated to be 0.40 % of regional natural gas production, with a 2σ confidence interval between 0.08 and 0.72 % of production. These emission rates as a percent of production are

  7. Quantifying methane emissions from natural gas production in north-eastern Pennsylvania

    Science.gov (United States)

    Barkley, Zachary R.; Lauvaux, Thomas; Davis, Kenneth J.; Deng, Aijun; Miles, Natasha L.; Richardson, Scott J.; Cao, Yanni; Sweeney, Colm; Karion, Anna; Smith, MacKenzie; Kort, Eric A.; Schwietzke, Stefan; Murphy, Thomas; Cervone, Guido; Martins, Douglas; Maasakkers, Joannes D.

    2017-11-01

    Natural gas infrastructure releases methane (CH4), a potent greenhouse gas, into the atmosphere. The estimated emission rate associated with the production and transportation of natural gas is uncertain, hindering our understanding of its greenhouse footprint. This study presents a new application of inverse methodology for estimating regional emission rates from natural gas production and gathering facilities in north-eastern Pennsylvania. An inventory of CH4 emissions was compiled for major sources in Pennsylvania. This inventory served as input emission data for the Weather Research and Forecasting model with chemistry enabled (WRF-Chem), and atmospheric CH4 mole fraction fields were generated at 3 km resolution. Simulated atmospheric CH4 enhancements from WRF-Chem were compared to observations obtained from a 3-week flight campaign in May 2015. Modelled enhancements from sources not associated with upstream natural gas processes were assumed constant and known and therefore removed from the optimization procedure, creating a set of observed enhancements from natural gas only. Simulated emission rates from unconventional production were then adjusted to minimize the mismatch between aircraft observations and model-simulated mole fractions for 10 flights. To evaluate the method, an aircraft mass balance calculation was performed for four flights where conditions permitted its use. Using the model optimization approach, the weighted mean emission rate from unconventional natural gas production and gathering facilities in north-eastern Pennsylvania approach is found to be 0.36 % of total gas production, with a 2σ confidence interval between 0.27 and 0.45 % of production. Similarly, the mean emission estimates using the aircraft mass balance approach are calculated to be 0.40 % of regional natural gas production, with a 2σ confidence interval between 0.08 and 0.72 % of production. These emission rates as a percent of production are lower than rates found in any

  8. 7 CFR 932.45 - Production research and marketing research and development projects.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Production research and marketing research and....45 Production research and marketing research and development projects. (a) The following activities... Secretary, establish or provide for the establishment of production research, and marketing research and...

  9. 7 CFR 915.45 - Production research, marketing research and development.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Production research, marketing research and... Production research, marketing research and development. The committee may, with the approval of the Secretary, establish or provide for the establishment of production research, marketing research and...

  10. Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts

    Directory of Open Access Journals (Sweden)

    Nur Shafika Mohd Sairazi

    2015-01-01

    Full Text Available Excitotoxicity is well recognized as a major pathological process of neuronal death in neurodegenerative diseases involving the central nervous system (CNS. In the animal models of neurodegeneration, excitotoxicity is commonly induced experimentally by chemical convulsants, particularly kainic acid (KA. KA-induced excitotoxicity in rodent models has been shown to result in seizures, behavioral changes, oxidative stress, glial activation, inflammatory mediator production, endoplasmic reticulum stress, mitochondrial dysfunction, and selective neurodegeneration in the brain upon KA administration. Recently, there is an emerging trend to search for natural sources to combat against excitotoxicity-associated neurodegenerative diseases. Natural products and plant extracts had attracted a considerable amount of attention because of their reported beneficial effects on the CNS, particularly their neuroprotective effect against excitotoxicity. They provide significant reduction and/or protection against the development and progression of acute and chronic neurodegeneration. This indicates that natural products and plants extracts may be useful in protecting against excitotoxicity-associated neurodegeneration. Thus, targeting of multiple pathways simultaneously may be the strategy to maximize the neuroprotection effect. This review summarizes the mechanisms involved in KA-induced excitotoxicity and attempts to collate the various researches related to the protective effect of natural products and plant extracts in the KA model of neurodegeneration.

  11. Improvement of Student Critical Thinking Skills with the Natural Product Mini Project Laboratory Learning

    Directory of Open Access Journals (Sweden)

    Aliefman Hakim

    2016-12-01

    Full Text Available This research aims to investigate effect of learning using natural product mini project laboratory on students’ critical thinking skills. The research was conducted on sixth semester of 59 students of chemistry and chemistry education program from one of the state universities in West Nusa Tenggara, Indonesia in 2012/2013. This research revealed class where the student learn using natural product mini project laboratory had more critical thinking skills than those using verification laboratory. The average n-gain of critical thinking skills for experiment class was 0.58 while for the control class was 0.37. The highest n-gain in the experiment class was 0.70 for “deciding on an action (selecting criteria to judge possible solutions indicators”, while the smallest n-gain was 0.47 for “the making and judging value of judgments (balancing, weighing, and deciding indicators. We concluded that the natural product mini project laboratory was better than verification laboratory in improving the students’ critical thinking skills.

  12. Toxic element contamination of natural health products and pharmaceutical preparations.

    Directory of Open Access Journals (Sweden)

    Stephen J Genuis

    Full Text Available BACKGROUND: Concern has recently emerged regarding the safety of natural health products (NHPs-therapies that are increasingly recommended by various health providers, including conventional physicians. Recognizing that most individuals in the Western world now consume vitamins and many take herbal agents, this study endeavored to determine levels of toxic element contamination within a range of NHPs. METHODS: Toxic element testing was performed on 121 NHPs (including Ayurvedic, traditional Chinese, and various marine-source products as well as 49 routinely prescribed pharmaceutical preparations. Testing was also performed on several batches of one prenatal supplement, with multiple samples tested within each batch. Results were compared to existing toxicant regulatory limits. RESULTS: Toxic element contamination was found in many supplements and pharmaceuticals; levels exceeding established limits were only found in a small percentage of the NHPs tested and none of the drugs tested. Some NHPs demonstrated contamination levels above preferred daily endpoints for mercury, cadmium, lead, arsenic or aluminum. NHPs manufactured in China generally had higher levels of mercury and aluminum. CONCLUSIONS: Exposure to toxic elements is occurring regularly as a result of some contaminated NHPs. Best practices for quality control-developed and implemented by the NHP industry with government oversight-is recommended to guard the safety of unsuspecting consumers.

  13. Core@shell Nanoparticles: Greener Synthesis Using Natural Plant Products

    Directory of Open Access Journals (Sweden)

    Mehrdad Khatami

    2018-03-01

    Full Text Available Among an array of hybrid nanoparticles, core-shell nanoparticles comprise of two or more materials, such as metals and biomolecules, wherein one of them forms the core at the center, while the other material/materials that were located around the central core develops a shell. Core-shell nanostructures are useful entities with high thermal and chemical stability, lower toxicity, greater solubility, and higher permeability to specific target cells. Plant or natural products-mediated synthesis of nanostructures refers to the use of plants or its extracts for the synthesis of nanostructures, an emerging field of sustainable nanotechnology. Various physiochemical and greener methods have been advanced for the synthesis of nanostructures, in contrast to conventional approaches that require the use of synthetic compounds for the assembly of nanostructures. Although several biological resources have been exploited for the synthesis of core-shell nanoparticles, but plant-based materials appear to be the ideal candidates for large-scale green synthesis of core-shell nanoparticles. This review summarizes the known strategies for the greener production of core-shell nanoparticles using plants extract or their derivatives and highlights their salient attributes, such as low costs, the lack of dependence on the use of any toxic materials, and the environmental friendliness for the sustainable assembly of stabile nanostructures.

  14. An Overview of Natural Gas Conversion Technologies for Co-Production of Hydrogen and Value-Added Solid Carbon Products

    Energy Technology Data Exchange (ETDEWEB)

    Dagle, Robert A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dagle, Vanessa [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bearden, Mark D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Holladay, Jamelyn D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Krause, Theodore R. [Argonne National Lab. (ANL), Argonne, IL (United States); Ahmed, Shabbir [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-11-16

    This report was prepared in response to the U.S. Department of Energy Fuel Cell Technologies Office Congressional Appropriation language to support research on carbon-free production of hydrogen using new chemical processes that utilize natural gas to produce solid carbon and hydrogen. The U.S. produces 9-10 million tons of hydrogen annually with more than 95% of the hydrogen produced by steam-methane reforming (SMR) of natural gas. SMR is attractive because of its high hydrogen yield; but it also converts the carbon to carbon dioxide. Non-oxidative thermal decomposition of methane to carbon and hydrogen is an alternative to SMR and produces CO2-free hydrogen. The produced carbon can be sold as a co-product, thus providing economic credit that reduces the delivered net cost of hydrogen. The combination of producing hydrogen with potentially valuable carbon byproducts has market value in that this allows greater flexibility to match the market prices of hydrogen and carbon. That is, the higher value product can subsidize the other in pricing decisions. In this report we highlight the relevant technologies reported in the literature—primarily thermochemical and plasma conversion processes—and recent research progress and commercial activities. Longstanding technical challenges include the high energetic requirements (e.g., high temperatures and/or electricity requirements) necessary for methane activation and, for some catalytic processes, the separation of solid carbon product from the spent catalyst. We assess current and new carbon product markets that could be served given technological advances, and we discuss technical barriers and potential areas of research to address these needs. We provide preliminary economic analysis for these processes and compare to other emerging (e.g., electrolysis) and conventional (e.g., SMR) processes for hydrogen production. The overarching conclusion of this study is that the cost of hydrogen can be potentially

  15. Regional Research Networking: A Stimulus to Research Collaboration and Research Productivity.

    Science.gov (United States)

    McElmurry, Beverly J.; Minckley, Barbara B.

    1986-01-01

    Models for collegial networking as a means of increasing the participants' scholarly productivity are presented. A Midwestern historical methodology research interest group is described as an example of the long-term benefits of forming networks of scholars. (MSE)

  16. High-resolution phenotypic profiling of natural products-induced effects on the single-cell level

    KAUST Repository

    Kremb, Stephan Georg

    2017-03-15

    Natural products (NPs) are highly evolved molecules making them a valuable resource for new therapeutics. Here we demonstrate the usefulness of broad-spectrum phenotypic profiling of NP-induced perturbations on single cells with imaging-based High-Content Screening to inform on physiology, mechanisms-of-actions, and multi-level toxicity. Our technology platform aims at broad applicability using a comprehensive marker panel with standardized settings streamlined towards an easy implementation in laboratories dedicated to natural products research.

  17. Actinide Foil Production for MPACT Research

    Energy Technology Data Exchange (ETDEWEB)

    Beller, Denis

    2012-10-30

    or UO2 in extremely thin layers (1 to 2 mg/cm2) on various media such as films, foils, or discs. After many months of investigation and trials in FY10 and 11, UNLV researchers developed a new method to produce pure UO2 deposits on foils using a unique approach, which has never been demonstrated, that involves dissolution of U3O8 directly into room temperature ionic liquid (RTIL) followed by electrodeposition from the RTIL-uDU solution (Th deposition from RTIL had been previously demonstrated). The high-purity dissolution of the U3O8 permits the use of RTIL solutions for deposition of U on metal foils in layers without introducing contamination. In FY10 and early FY11 a natural U surrogate for the uDU was used to investigate this and other techniques. In this research project UNLV will deposit directly from RTIL to produce uDU and Th foils devoid of possible contaminants. After these layers have been deposited, they will be examined for purity and uniformity. UNLV will complete the development and demonstration of the RTIL technology/ methodology to prepare uDU and Th samples for use in constructing fast-neutron detectors. Although this material was purchased for use in research using fast-fission chamber detectors for active inspection techniques for MPACT, it could also contribute to R&D for other applications, such as cross section measurements or neutron spectroscopy for national security

  18. A Review on the Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Geniposide, a Natural Product

    Directory of Open Access Journals (Sweden)

    Mingqiu Shan

    2017-10-01

    Full Text Available Iridoid glycosides are natural products occurring widely in many herbal plants. Geniposide (C17H24O10 is a well-known one, present in nearly 40 species belonging to various families, especially the Rubiaceae. Along with this herbal component, dozens of its natural derivatives have also been isolated and characterized by researchers. Furthermore, a large body of pharmacological evidence has proved the various biological activities of geniposide, such as anti-inflammatory, anti-oxidative, anti-diabetic, neuroprotective, hepatoprotective, cholagogic effects and so on. However, there have been some research articles on its toxicity in recent years. Therefore, this review paper aims to provide the researchers with a comprehensive profile of geniposide on its phytochemistry, pharmacology, pharmacokinetics and toxicology in order to highlight some present issues and future perspectives as well as to help us develop and utilize this iridoid glycoside more efficiently and safely.

  19. Natural Language Processing Technologies in Radiology Research and Clinical Applications

    Science.gov (United States)

    Cai, Tianrun; Giannopoulos, Andreas A.; Yu, Sheng; Kelil, Tatiana; Ripley, Beth; Kumamaru, Kanako K.; Rybicki, Frank J.

    2016-01-01

    The migration of imaging reports to electronic medical record systems holds great potential in terms of advancing radiology research and practice by leveraging the large volume of data continuously being updated, integrated, and shared. However, there are significant challenges as well, largely due to the heterogeneity of how these data are formatted. Indeed, although there is movement toward structured reporting in radiology (ie, hierarchically itemized reporting with use of standardized terminology), the majority of radiology reports remain unstructured and use free-form language. To effectively “mine” these large datasets for hypothesis testing, a robust strategy for extracting the necessary information is needed. Manual extraction of information is a time-consuming and often unmanageable task. “Intelligent” search engines that instead rely on natural language processing (NLP), a computer-based approach to analyzing free-form text or speech, can be used to automate this data mining task. The overall goal of NLP is to translate natural human language into a structured format (ie, a fixed collection of elements), each with a standardized set of choices for its value, that is easily manipulated by computer programs to (among other things) order into subcategories or query for the presence or absence of a finding. The authors review the fundamentals of NLP and describe various techniques that constitute NLP in radiology, along with some key applications. ©RSNA, 2016 PMID:26761536

  20. Natural Language Processing Technologies in Radiology Research and Clinical Applications.

    Science.gov (United States)

    Cai, Tianrun; Giannopoulos, Andreas A; Yu, Sheng; Kelil, Tatiana; Ripley, Beth; Kumamaru, Kanako K; Rybicki, Frank J; Mitsouras, Dimitrios

    2016-01-01

    The migration of imaging reports to electronic medical record systems holds great potential in terms of advancing radiology research and practice by leveraging the large volume of data continuously being updated, integrated, and shared. However, there are significant challenges as well, largely due to the heterogeneity of how these data are formatted. Indeed, although there is movement toward structured reporting in radiology (ie, hierarchically itemized reporting with use of standardized terminology), the majority of radiology reports remain unstructured and use free-form language. To effectively "mine" these large datasets for hypothesis testing, a robust strategy for extracting the necessary information is needed. Manual extraction of information is a time-consuming and often unmanageable task. "Intelligent" search engines that instead rely on natural language processing (NLP), a computer-based approach to analyzing free-form text or speech, can be used to automate this data mining task. The overall goal of NLP is to translate natural human language into a structured format (ie, a fixed collection of elements), each with a standardized set of choices for its value, that is easily manipulated by computer programs to (among other things) order into subcategories or query for the presence or absence of a finding. The authors review the fundamentals of NLP and describe various techniques that constitute NLP in radiology, along with some key applications. ©RSNA, 2016.

  1. Natural or Plant Products for the Treatment of Neurological Disorders: Current Knowledge.

    Science.gov (United States)

    Parvez, Mohammad Khalid

    2018-01-01

    In recent decades, complementary and alternative medicine (CAM) has become very popular in the treatment of several chronic diseases. Natural products as one of the CAM modalities offer potential opportunities to discover lead compounds for novel drug development. The use of CAM or natural products in the prevention of neurodegenerative diseases is comparatively a newer area. A structured online literature search for peer-reviewed research articles was conducted on the PubMed, Europe PMC, Medline and Google Scholar portals, using phrases: natural products for neurologic disorders, phytomedicine for neurodegenerative diseases, natural therapeutics for neurological symptopms etc. Results: The retrieved data showed the natural therapeutics with anti-oxidative and anti-inflammatory salutations evidently plays a crucial role in protecting neurons. Of these, the most promising are caffeine, trigonelline, shogaol, curcumin, resveratrol, baicalein, wogonin, ginsenosides, tanshinones, withanolides, picrosides, parthenolide, cannabinoids, Devil's claw and white willow bark, including Chinese formulations Renshen Shouwu and Shengmai San. Though several herbs and their active ingredients have been studied in laboratory and clinical settings, only a few have been investigated for their molecular mechanisms of action. Notably, despite the promising and safe therapeutic benefits of CAM/herbal medicines, there exists a possible risk when combining them with prescription drugs. As a result, many drugs have shown changes in blood pressure, hepatotoxicity, seizures etc. when combined with certain herbs. Certainly, extensive work is needed to make sure that patients should take a regimen of protective and restorative therapy under an experienced healthcare professional. This article updates on the current knowledge of promising natural products used in neurological disorders. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  2. Building a discovery partnership with Sarawak Biodiversity Centre: a gateway to access natural products from the rainforests.

    Science.gov (United States)

    Yeo, Tiong Chia; Naming, Margarita; Manurung, Rita

    2014-03-01

    The Sarawak Biodiversity Centre (SBC) is a state government agency which regulates research and promotes the sustainable use of biodiversity. It has a program on documentation of traditional knowledge (TK) and is well-equipped with facilities for natural product research. SBC maintains a Natural Product Library (NPL) consisting of local plant and microbial extracts for bioprospecting. The NPL is a core discovery platform for screening of bioactive compounds by researchers through a formal agreement with clear benefit sharing obligations. SBC aims to develop partnerships with leading institutions and the industries to explore the benefits of biodiversity.

  3. Effects of bioenergy production on European nature conservation options

    Science.gov (United States)

    Schleupner, C.; Schneider, U. A.

    2009-04-01

    To increase security of energy supply and reduce greenhouse gas (GHG) emissions the European Commission set out a long-term strategy for renewable energy in the European Union (EU). Bioenergy from forestry and agriculture plays a key role for both. Since the last decade a significant increase of biomass energy plantations has been observed in Europe. Concurrently, the EU agreed to halt the loss of biodiversity within its member states. One measure is the Natura2000 network of important nature sites that actually covers about 20% of the EU land surface. However, to fulfil the biodiversity target more nature conservation and restoration sites need to be designated. There are arising concerns that an increased cultivation of bioenergy crops will decrease the land available for nature reserves and for "traditional" agriculture and forestry. In the following the economic and ecological impacts of structural land use changes are demonstrated by two examples. First, a case study of land use changes on the Eiderstedt peninsula in Schleswig-Holstein/Germany evaluates the impacts of grassland conversion into bioenergy plantations under consideration of selected meadow birds. Scenarios indicate not only a quantitative loss of habitats but also a reduction of habitat quality. The second study assesses the role of bioenergy production in light of possible negative impacts on potential wetland conservation sites in Europe. By coupling the spatial wetland distribution model "SWEDI" (cf. SCHLEUPNER 2007) to the European Forest and Agricultural Sector Optimization Model (EUFASOM; cf. SCHNEIDER ET AL. 2008) economic and environmental aspects of land use are evaluated simultaneously. This way the costs and benefits of the appropriate measures and its consequences for agriculture and forestry are investigated. One aim is to find the socially optimal balance between alternative wetland uses by integrating biological benefits - in this case wetlands - and economic opportunities - here

  4. Texts of the New Nature: Problems of Interdisciplinary Research

    Directory of Open Access Journals (Sweden)

    Kazakova E.I.,

    2017-02-01

    Full Text Available The paper explores a new research direction unfolding at the junction of modern textual criticism and modernization challenges in education. It outlines the theoretical basis for constructing a model of the «new literacy» representative of the 21st century. The paper contains an attempt to describe the main trends in the changes of text: rejection of linearity, shrinkage of text volume, orientation to «small text structures», duplicative character of different sign systems in the content reflection, increase of interactivity, feedback forms development, emergence of «new forms of authorship» and a number of other trends. Examples are given of new literature, created in the form of comics, presentations, infographics, drawn notes. The author reveals the scope of «the texts of the new nature» through the provision of its characteristics; describes two main technologies of formation of such texts; provides experimental data that characterize the process of perception of this kind of texts; and, finally, formulates priority research issues.

  5. A systematic review of natural health product treatment for vitiligo

    Directory of Open Access Journals (Sweden)

    Boon Heather S

    2008-05-01

    Full Text Available Abstract Background Vitiligo is a hypopigmentation disorder affecting 1 to 4% of the world population. Fifty percent of cases appear before the age of 20 years old, and the disfigurement results in psychiatric morbidity in 16 to 35% of those affected. Methods Our objective was to complete a comprehensive, systematic review of the published scientific literature to identify natural health products (NHP such as vitamins, herbs and other supplements that may have efficacy in the treatment of vitiligo. We searched eight databases including MEDLINE and EMBASE for vitiligo, leucoderma, and various NHP terms. Prospective controlled clinical human trials were identified and assessed for quality. Results Fifteen clinical trials were identified, and organized into four categories based on the NHP used for treatment. 1 L-phenylalanine monotherapy was assessed in one trial, and as an adjuvant to phototherapy in three trials. All reported beneficial effects. 2 Three clinical trials utilized different traditional Chinese medicine products. Although each traditional Chinese medicine trial reported benefit in the active groups, the quality of the trials was poor. 3 Six trials investigated the use of plants in the treatment of vitiligo, four using plants as photosensitizing agents. The studies provide weak evidence that photosensitizing plants can be effective in conjunction with phototherapy, and moderate evidence that Ginkgo biloba monotherapy can be useful for vitiligo. 4 Two clinical trials investigated the use of vitamins in the therapy of vitiligo. One tested oral cobalamin with folic acid, and found no significant improvement over control. Another trial combined vitamin E with phototherapy and reported significantly better repigmentation over phototherapy only. It was not possible to pool the data from any studies for meta-analytic purposes due to the wide difference in outcome measures and poor quality ofreporting. Conclusion Reports investigating the

  6. Natural products as starting points for future anti-malarial therapies: going back to our roots?

    Directory of Open Access Journals (Sweden)

    Wells Timothy NC

    2011-03-01

    medicinal products already used by the community. This first step forms a solid basis of observations, before moving to in vivo pharmacological characterization and ultimately identifying the active ingredient. A large part of the population uses herbal medicinal products despite limited numbers of well-controlled clinical studies. Increased awareness by the regulators and public health bodies of the need for safety information on herbal medicinal products also lends support to obtaining more clinical data on such products. Conclusions The relative paucity of new herbal medicinal product scaffolds active against malaria results discovered in recent years suggest it is time to re-evaluate the ‘smash and grab’ approach of randomly testing purified natural products and replace it with a patient-data led approach. This will require a change of perspective form many in the field. It will require an investment in standardisation in several areas, including: the ethnopharmacology and design and reporting of clinical observation studies, systems for characterizing anti-malarial activity of patient plasma samples ex vivo followed by chemical and pharmacological characterisation of extracts from promising sources. Such work falls outside of the core mandate of the product development partnerships, such as MMV, and so will require additional support. This call is timely, given the strong interest from researchers in disease endemic countries to support the research arm of a malaria eradication agenda. Para-national institutions such as the African Network for Drugs and Diagnostics Innovation (ANDi will play a major role in facilitating the development of their natural products patrimony and possibly clinical best practice to bring forward new therapeutics. As in the past, with quinine, lapinone and artemisinin, once the activity of herbal medicinal products in humans is characterised, it can be used to identify new molecular scaffolds which will form the basis of the next

  7. Natural products as promising drug candidates for the treatment of Alzheimer's disease: molecular mechanism aspect.

    Science.gov (United States)

    Ansari, Niloufar; Khodagholi, Fariba

    2013-07-01

    Alzheimer's disease (AD) is the most common neurodegenerative disorder to date, with no curative or preventive therapy. Histopathological hallmarks of AD include deposition of β-amyloid plaques and formation of neurofibrillary tangles. Extent studies on pathology of the disease have made important discoveries regarding mechanism of disease and potential therapeutic targets. Many cellular changes including oxidative stress, disruption of Ca2+ homeostasis, inflammation, metabolic disturbances, and accumulation of unfolded/misfolded proteins can lead to programmed cell death in AD. Despite intensive research, only five approved drugs are available for the management of AD. Hence, there is a need to look at alternative therapies. Use of natural products and culinary herbs in medicine has gained popularity in recent years. Several natural substances with neuroprotective effects have been widely studied. Most of these compounds have remarkable antioxidant properties and act mainly by scavenging free radical species. Some of them increase cell survival and improve cognition by directly affecting amyloidogenesis and programmed cell death pathways. Further studies on these natural products and their mechanism of action, parallel with the use of novel pharmaceutical drug design and delivery techniques, enable us to offer an addition to conventional medicine. This review discussed some natural products with potential neuroprotective properties against Aβ with respect to their mechanism of action.

  8. Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD

    Directory of Open Access Journals (Sweden)

    Qian Chen

    2017-01-01

    Full Text Available As a sugar additive, fructose is widely used in processed foods and beverages. Excessive fructose consumption can cause hepatic steatosis and dyslipidemia, leading to the development of metabolic syndrome. Recent research revealed that fructose-induced nonalcoholic fatty liver disease (NAFLD is related to several pathological processes, including: (1 augmenting lipogenesis; (2 leading to mitochondrial dysfunction; (3 stimulating the activation of inflammatory pathways; and (4 causing insulin resistance. Cellular signaling research indicated that partial factors play significant roles in fructose-induced NAFLD, involving liver X receptor (LXRα, sterol regulatory element binding protein (SREBP-1/1c, acetyl-CoA carboxylase (ACC, fatty acid synthase (FAS, stearoyl-CoA desaturase (SCD, peroxisome proliferator–activated receptor α (PPARα, leptin nuclear factor-erythroid 2-related factor 2 (Nrf2, nuclear factor kappa B (NF-κB, tumor necrosis factor α (TNF-α, c-Jun amino terminal kinase (JNK, phosphatidylinositol 3-kinase (PI3K and adenosine 5′-monophosphate (AMP-activated protein kinase (AMPK. Until now, a series of natural products have been reported as regulators of NAFLD in vivo and in vitro. This paper reviews the natural products (e.g., curcumin, resveratrol, and (−-epicatechin and their mechanisms of ameliorating fructose-induced NAFLD over the past years. Although, as lead compounds, natural products usually have fewer activities compared with synthesized compounds, it will shed light on studies aiming to discover new drugs for NAFLD.

  9. Amersham research products 1985/86

    International Nuclear Information System (INIS)

    1985-01-01

    The publication contains data on this technology in general, on quality assurance in analysis and applications, on special synthesis and tritium labelling services and on radioactivity measurements. Included are a product list of radionuclides, an alphabetical product list with product specifications and structural formulas and a list of RIA kits and control sera for clinical diagnoses. (DG) [de

  10. Research in Organic Animals and Livestock Production

    DEFF Research Database (Denmark)

    Vaarst, Mette

    2009-01-01

    developed in Western Europe and USA, where they are primarily niche products for consumers who give priority to environmental and animal welfare concerns. In these countries organic livestock production offers the option of establishing a niche product that can be sold at a higher price, e.g. as for milk...

  11. Scientific research in the natural sciences in South Africa: A scientometric study

    Directory of Open Access Journals (Sweden)

    Radhamany Sooryamoorthy

    2013-07-01

    Full Text Available As a leading producer of scientific publications on the African continent, South Africa has made remarkable progress. However, attempts are yet to be made to comprehend the empirical reality of scientific production in South Africa. One way to do this is to analyse specific science disciplines (such as the natural sciences, publication outputs and their features. A bibliometric study was undertaken of the publication trends and patterns of South African researchers in the natural sciences from 1975 to 2005 (choosing selected sample years, using the Thomson Reuters� Web of Knowledge database of selected indexed natural science journals. Characteristics of natural science publications, such as the trends over the years, were revealed as well as the collaborative dimensions involved in the production of scientific papers in these disciplines in South Africa. The connection between collaboration and publication, as well as between collaboration and sectors of authors was evident. The key findings of this study were that authors were based mostly in universities and were collaborative in their research endeavours. In addition, the participation of international collaborators has increased.

  12. Natural Products as Leads in Schistosome Drug Discovery

    Directory of Open Access Journals (Sweden)

    Bruno J. Neves

    2015-01-01

    Full Text Available Schistosomiasis is a neglected parasitic tropical disease that claims around 200,000 human lives every year. Praziquantel (PZQ, the only drug recommended by the World Health Organization for the treatment and control of human schistosomiasis, is now facing the threat of drug resistance, indicating the urgent need for new effective compounds to treat this disease. Therefore, globally, there is renewed interest in natural products (NPs as a starting point for drug discovery and development for schistosomiasis. Recent advances in genomics, proteomics, bioinformatics, and cheminformatics have brought about unprecedented opportunities for the rapid and more cost-effective discovery of new bioactive compounds against neglected tropical diseases. This review highlights the main contributions that NP drug discovery and development have made in the treatment of schistosomiasis and it discusses how integration with virtual screening (VS strategies may contribute to accelerating the development of new schistosomidal leads, especially through the identification of unexplored, biologically active chemical scaffolds and structural optimization of NPs with previously established activity.

  13. Chapter 7. Cloning and analysis of natural product pathways.

    Science.gov (United States)

    Gust, Bertolt

    2009-01-01

    The identification of gene clusters of natural products has lead to an enormous wealth of information about their biosynthesis and its regulation, and about self-resistance mechanisms. Well-established routine techniques are now available for the cloning and sequencing of gene clusters. The subsequent functional analysis of the complex biosynthetic machinery requires efficient genetic tools for manipulation. Until recently, techniques for the introduction of defined changes into Streptomyces chromosomes were very time-consuming. In particular, manipulation of large DNA fragments has been challenging due to the absence of suitable restriction sites for restriction- and ligation-based techniques. The homologous recombination approach called recombineering (referred to as Red/ET-mediated recombination in this chapter) has greatly facilitated targeted genetic modifications of complex biosynthetic pathways from actinomycetes by eliminating many of the time-consuming and labor-intensive steps. This chapter describes techniques for the cloning and identification of biosynthetic gene clusters, for the generation of gene replacements within such clusters, for the construction of integrative library clones and their expression in heterologous hosts, and for the assembly of entire biosynthetic gene clusters from the inserts of individual library clones. A systematic approach toward insertional mutation of a complete Streptomyces genome is shown by the use of an in vitro transposon mutagenesis procedure.

  14. [Sugar Chain Construction of Functional Natural Products Using Plant Glucosyltransferases].

    Science.gov (United States)

    Mizukami, Hajime

    2015-01-01

    Plant secondary product glycosyltransferases belong to family 1 of the glycosyltransferase superfamily and mediate the transfer of a glycosyl residue from activated nucleotide sugars to lipophilic small molecules, thus affecting the solubility, stability and pharmacological activities of the sugar-accepting compounds. The biotechnological application of plant glycosyltransferases in glycoside synthesis has attracted attention because enzymatic glycosylation offers several advantages over chemical methods, including (1) avoiding the use of harsh conditions and toxic catalysts, (2) providing strict control of regio-and stereo-selectivity and (3) high efficiency. This review describes the in vivo and in vitro glycosylation of natural organic compounds using glycosyltransferases, focusing on our investigation of enzymatic synthesis of curcumin glycosides. Our current efforts toward functional characterization of some glycosyltransferases involved in the biosynthesis of iridoids and crocin, as well as in the sugar chain elongation of quercetin glucosides, are described. Finally, I describe the relationship of the structure of sugar chains and the intestinal absorption which was investigated using chemoenzymatically synthesized quercetin glycosides.

  15. Identification and quantification of the halogenated natural product BC-3

    Energy Technology Data Exchange (ETDEWEB)

    Melcher, J.; Olbrich, D.; Vetter, W. [Hohenheim Univ., Stuttgart (Germany). Inst. fuer Lebensmittelchemie; Marsh, G. [Stockholm Univ. (Sweden). Dept. of Environmental Chemistry; Gaus, C.; Mueller, J.F. [National Research Centre for Environmental Toxicology, Coopers Plains (Australia)

    2004-09-15

    Halogenated natural products (HNPs) of marine origin are increasingly recognized as critical residues in foodstuff (e. g. fish) and environmental samples (e. g. marine mammals and birds). Some of these HNPs (Q1, MHC-1, BC-2, and HDBPs including BC-10) were detected in diverse fish and marine mammal samples at concentrations sometimes exceeding those of PCBs, DDT, and other anthropogenic pollutants. Recent studies with marine mammal samples from Australia led to the detection of six abundant HNPs (Q1, BC-1, BC-2, BC-3, BC-10, and BC-11). In the meantime, Q1 was identified as heptachloro-1{sup '}-methyl-1,2{sup '}-bipyrrole, BC-2 as 4,6-dibromo-2-(2{sup '},4{sup '}-dibromo)phenoxyanisole, BC- 10 as 1,1{sup '}-dimethyl-3,3{sup '},4,4{sup '}-tetrabromo-5,5{sup '}-dichloro-2,2{sup '}-bipyrrole, and BC-11 as 3,5-dibromo- 2-(3{sup '},5{sup '}-dibromo,2{sup '}-methoxy)phenoxyanisole. However the identity of BC-1 and BC-3 remained unclear. The goal of the present study was the identification of BC-3. The tetrabromo compound BC-3 has previously been detected in marine mammals from four continents. Furthermore, we attempted establishing quantitative concentrations in diverse marine biota samples.

  16. Formulating natural based cosmetic product - irradiated herbal lip balm

    International Nuclear Information System (INIS)

    Seri Chempaka Mohd Yusof; Ros Anita Ahmad Ramli; Foziah Ali; Zainab Harun

    2007-01-01

    Herbal lip balm was formulated in efforts to produce a safe product, attractive with multifunctional usage i.e. prevent chap lips, reduce mouth odour and benefits in improving the health quality. Problems faced in constructing formulations of herbal lip balm were focused to the extraction of anthocyanins, the stability of the pigments in the formulations and changes of colour during irradiation for the sterilization of herbal lip balm. Natural pigment, anthocyanin was used as a colorant agent in herbal lip balm, obtained from various herbs and vegetables i.e. Hibiscus sabdariffa L. (roselle), Brassica oleracea var. capitata f. rubra (red cabbage) and Daucus carota (carrot). Water based extraction method was used in extracting the anthocyanins. The incorporation of honey in the formulations improved the colour of the lip balm. The usage of plant based ingredient i.e. cocoa butter substituting the normal based ingredient i.e. petroleum jelly in lip balm also affecting the colour of herbal lip balm. Irradiation at 2.5, 5.0 and 10 kGy was carried out as preservation and reducing of microbial load of the herbal lip balm and changes in colour were observed in formulations irradiated at 10 kGy. (Author)

  17. Natural products as a resource for biologically active compounds

    International Nuclear Information System (INIS)

    Hanke, F.J.

    1986-01-01

    The goal of this study was to investigate various sources of biologically active natural products in an effort to identify the active pesticidal compounds involved. The study is divided into several parts. Chapter 1 contains a discussion of several new compounds from plant and animal sources. Chapter 2 introduces a new NMR technique. In section 2.1 a new technique for better utilizing the lanthanide relaxation agent Gd(fod) 3 is presented which allows the predictable removal of resonances without line broadening. Section 2.2 discusses a variation of this technique for use in an aqueous solvent by applying this technique towards identifying the binding sites of metals of biological interest. Section 2.3 presents an unambiguous 13 C NMR assignment of melibiose. Chapter 3 deals with work relating to the molting hormone of most arthropods, 20-hydroxyecdysone. Section 3.1 discusses the use of two-dimensional NMR (2D NMR) to assign the 1 H NMR spectrum of this biologically important compound. Section 3.2 presents a new application for Droplet countercurrent chromatography (DCCC). Chapter 4 presents a basic improvement to the commercial DCCC instrument that is currently being applied to future commercial instruments. Chapter 5 discusses a curious observation of the effects that two previously known compounds, nagilactone C and (-)-epicatechin, have on lettuce and rice and suggest a possible new role for the ubiquitous flavanol (-)-epicatechin in plants

  18. Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors.

    Directory of Open Access Journals (Sweden)

    Scott B Vafai

    Full Text Available Deficiency of mitochondrial complex I is encountered in both rare and common diseases, but we have limited therapeutic options to treat this lesion to the oxidative phosphorylation system (OXPHOS. Idebenone and menadione are redox-active molecules capable of rescuing OXPHOS activity by engaging complex I-independent pathways of entry, often referred to as "complex I bypass." In the present study, we created a cellular model of complex I deficiency by using CRISPR genome editing to knock out Ndufa9 in mouse myoblasts, and utilized this cell line to develop a high-throughput screening platform for novel complex I bypass factors. We screened a library of ~40,000 natural product extracts and performed bioassay-guided fractionation on a subset of the top scoring hits. We isolated four plant-derived 1,4-naphthoquinone complex I bypass factors with structural similarity to menadione: chimaphilin and 3-chloro-chimaphilin from Chimaphila umbellata and dehydro-α-lapachone and dehydroiso-α-lapachone from Stereospermum euphoroides. We also tested a small number of structurally related naphthoquinones from commercial sources and identified two additional compounds with complex I bypass activity: 2-methoxy-1,4-naphthoquinone and 2-methoxy-3-methyl-1,4,-naphthoquinone. The six novel complex I bypass factors reported here expand this class of molecules and will be useful as tool compounds for investigating complex I disease biology.

  19. Plants’ Natural Products as Alternative Promising Anti-Candida Drugs

    Science.gov (United States)

    Soliman, Sameh; Alnajdy, Dina; El-Keblawy, Ali A.; Mosa, Kareem A.; Khoder, Ghalia; Noreddin, Ayman M.

    2017-01-01

    Candida is a serious life-threatening pathogen, particularly with immunocompromised patients. Candida infections are considered as a major cause of morbidity and mortality in a broad range of immunocompromised patients. Candida infections are common in hospitalized patients and elderly people. The difficulty to eradicate Candida infections is owing to its unique switch between yeast and hyphae forms and more likely to biofilm formations that render resistance to antifungal therapy. Plants are known sources of natural medicines. Several plants show significant anti-Candida activities and some of them have lower minimum inhibitory concentration, making them promising candidates for anti-Candida therapy. However, none of these plant products is marketed for anti-Candida therapy because of lack of sufficient information about their efficacy, toxicity, and kinetics. This review revises major plants that have been tested for anti-Candida activities with recommendations for further use of some of these plants for more investigation and in vivo testing including the use of nanostructure lipid system. PMID:28989245

  20. Research and development of HTTR hydrogen production systems

    International Nuclear Information System (INIS)

    Shiozawa, Shusaku; Ogawa, Masuro; Inagaki, Yoshiyuki; Onuki, Kaoru; Takeda, Tetsuaki; Nishihara, Tetsuo; Hayashi, Koji; Kubo, Shinji; Inaba, Yoshitomo; Ohashi, Hirofumi

    2002-01-01

    The Japan Atomic Energy Research Institute (JAERI) has constructed the High Temperature Engineering Test Reactor (HTTR) with a thermal output of 30MW and a reactor out let coolant temper at ure of 950 .deg. C. There search and development (R and D) program on nuclear production of hydrogen was started on January in 1997 as a study consigned by Ministry of Education, Culture, Sports, Science and Technology. A hydrogen production system connected to the HTTR is being designed to be able to produce hydrogen of about 4000m 3 /h by steam reforming of natural gas, using a nuclear heat of 10MW supplied by the HTTR hydrogen production system. In order to confirm controllability, safety and performance of key components in the HTTR hydrogen production system, the facility for the out-of-pile test was constructed on the scale of approximately 1/30 of the HTTR hydrogen production system. In parallel to the out-of-pile test, the following tests as essential problem, a corrosion test of a reforming tube, a permeation test of hydrogen isotopes through heat exchanger and reforming tubes, and an integrity test of a high-temperature isolation valve are carried out to obtain detailed data for safety review and development of analytical codes. Other basis studies on the hydrogen production technology of thermochemical water splitting called an iodine sulfur (IS) process, has been carried out for more effective and various uses of nuclear heat. This paper describes the present status and a future plan on the R and D of the HTTR hydrogen production systems in JAERI

  1. Target discovery focused approaches to overcome bottlenecks in the exploitation of antimycobacterial natural products.

    Science.gov (United States)

    Baptista, Rafael; Bhowmick, Sumana; Nash, Robert J; Baillie, Les; Mur, Luis Aj

    2018-04-01

    Tuberculosis is a major global health hazard. The search for new antimycobacterials has focused on such as screening combinational chemistry libraries or designing chemicals to target predefined pockets of essential bacterial proteins. The relative ineffectiveness of these has led to a reappraisal of natural products for new antimycobacterial drug leads. However, progress has been limited, we suggest through a failure in many cases to define the drug target and optimize the hits using this information. We highlight methods of target discovery needed to develop a drug into a candidate for clinical trials. We incorporate these into suggested analysis pipelines which could inform the research strategies to accelerate the development of new drug leads from natural products.

  2. Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines

    Directory of Open Access Journals (Sweden)

    Norman Ratcliffe

    2014-01-01

    Full Text Available Except for honey as food, and silk for clothing and pollination of plants, people give little thought to the benefits of insects in their lives. This overview briefly describes significant recent advances in developing insect natural products as potential new medicinal drugs. This is an exciting and rapidly expanding new field since insects are hugely variable and have utilised an enormous range of natural products to survive environmental perturbations for 100s of millions of years. There is thus a treasure chest of untapped resources waiting to be discovered. Insects products, such as silk and honey, have already been utilised for thousands of years, and extracts of insects have been produced for use in Folk Medicine around the world, but only with the development of modern molecular and biochemical techniques has it become feasible to manipulate and bioengineer insect natural products into modern medicines. Utilising knowledge gleaned from Insect Folk Medicines, this review describes modern research into bioengineering honey and venom from bees, silk, cantharidin, antimicrobial peptides, and maggot secretions and anticoagulants from blood-sucking insects into medicines. Problems and solutions encountered in these endeavours are described and indicate that the future is bright for new insect derived pharmaceuticals treatments and medicines.

  3. An analysis of FDA-approved drugs: natural products and their derivatives.

    Science.gov (United States)

    Patridge, Eric; Gareiss, Peter; Kinch, Michael S; Hoyer, Denton

    2016-02-01

    Natural products contribute greatly to the history and landscape of new molecular entities (NMEs). An assessment of all FDA-approved NMEs reveals that natural products and their derivatives represent over one-third of all NMEs. Nearly one-half of these are derived from mammals, one-quarter from microbes and one-quarter from plants. Since the 1930s, the total fraction of natural products has diminished, whereas semisynthetic and synthetic natural product derivatives have increased. Over time, this fraction has also become enriched with microbial natural products, which represent a significant portion of approved antibiotics, including more than two-thirds of all antibacterial NMEs. In recent years, the declining focus on natural products has impacted the pipeline of NMEs from specific classes, and this trend is likely to continue without specific investment in the pursuit of natural products. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. Women Academics and Research Productivity: An International Comparison

    Science.gov (United States)

    Aiston, Sarah Jane; Jung, Jisun

    2015-01-01

    In the prestige economy of higher education, research productivity is highly prized. Previous research indicates, however, a gender gap with respect to research output. This gap is often explained by reference to familial status and responsibilities. In this article, we examine the research productivity gender gap from an international perspective…

  5. Pre-fractionated Microbial Samples – The Second Generation Natural Products Library at Wyeth

    Directory of Open Access Journals (Sweden)

    Melissa M. Wagenaar

    2008-06-01

    Full Text Available From the beginning of the antibiotic era in the 1940s to the present, Wyeth has sustained an active research program in the area of natural products discovery. This program has continually evolved through the years in order to best align with the “current” drug discovery paradigm in the pharmaceutical industry. The introduction of highthroughput screening and the miniaturization of assays have created a need to optimize natural product samples to better suit these new technologies. Furthermore, natural product programs are faced with an ever shortening time period from hit detection to lead characterization. To address these issues, Wyeth has created a pre-fractionated natural products library using reversed-phase HPLC to complement their existing library of crude extracts. The details of the pre-fractionated library and a cost-benefit analysis will be presented in this review.

  6. RESEARCH METHODOLOGY ON NATURAL NUTRITION OF FRESH-WATER FISH

    Directory of Open Access Journals (Sweden)

    Marina Piria

    2001-03-01

    Full Text Available This paper offers the entire review on the research methodology in natural nutrition of fresh-water fish. The data on fresh-water fish nutrition, particularly on fish of lower economic value, is inadequate. Reviewing the literature on assesment of nutritional parameters, the authors obviously use differenet approaches and methods. This paper is about most frequently used parameteres in qualitative and quantitative analysis. The qualitative analysis of food structure is the overall list of determinable taxa (mostlyu species and genera. The quantitative analysis comprises the assessment of particular nutritional categories by nutritional indices and coefficients. Bio-identification and numeric data processing can have numerous drawbacsk such as effect of regurgitation or the degree of digestion of the prey. The analyses of those effects proceed through statistical data processing in order to include spatial distribution of certain prey categories as well. The importance of this data is to determine the nutritional needs of potential species for culture as well as to come up with new insights on a particular aquatic ecosystem.

  7. ENVIRONMENTAL NATURE OF PERSONAL HELPLESSNESS: RESULTS OF EMPIRICAL RESEARCH

    Directory of Open Access Journals (Sweden)

    Diana Aleksandrovna Tsiring

    2015-12-01

    Full Text Available The article is devoted to the nature of personal helplessness. Defining personal helplessness from the position of subject-activity approach as the quality of the subject, which is the unity of certain personal characteristics, resulting from the interaction of internal to external conditions, determines the low level of subjectivity, the question of the environmental factors of its formation in adolescents.The purpose of research – to reveal features of family relationships and their contribution to the formation of personal helplessness in adolescents. From the perspective of systemic approach the authors argue that the communicative processes in the family helpless teen lots of different disorders than family relationships independent teenagers. The study has received the confirmation of the hypothesis that the violation of family relationships are the environmental factors of formation of personal helplessness. Named the major violations of interpersonal communication in the family, determining personal helplessness in adolescents: a dominant giperprotektsiya, increased moral responsibility, abuse, inconsistent parenting style.

  8. Case study of information product for strategy research, planning research, and policy research

    International Nuclear Information System (INIS)

    Yuan Yujun; Zou Lin; Liu Qun; Wang Yongping

    2010-01-01

    Soft science research is significant and can directly support the decision-making and development. The strategy research, planning research, and policy research each play an important role in soft science research. As the National Strategy of Informatization being implemented and advanced, some progress are made and some special information tools are produced in the process of strengthening the development research with information technologies. At first, the article introduced some cases of information products application, such as the domestic and overseas information products for energy strategy research and planning research and policy research, the governmental management information system for planning and investment, examination and approval and permission system for the planning of the land for construction, China agriculture decision support system and so on, and also gave a brief analysis on the theories and methods, main functions and application status. And then, with a analysis on the features of the works of development planning of China National Nuclear Corporation (CNNC) development, this article gave some suggestions on how to strengthen the development of information system for the development planning of the CNNC. (authors)

  9. Determinants of Research Productivity in Spanish Academia

    Science.gov (United States)

    Albert, Cecilia; Davia, María A.; Legazpe, Nuria

    2016-01-01

    This article aims to widen the empirical evidence about the determinants of Spanish academics' publication productivity across fields of study. We use the Spanish Survey on Human Resources in Science and Technology addressed to Spanish resident PhDs employed in Spanish universities as academics. Productivity is measured as the total number of…

  10. DEVELOPMENT OF RESERVOIR CHARACTERIZATION TECHNIQUES AND PRODUCTION MODELS FOR EXPLOITING NATURALLY FRACTURED RESERVOIRS

    Energy Technology Data Exchange (ETDEWEB)

    Michael L. Wiggins; Raymon L. Brown; Faruk Civan; Richard G. Hughes

    2002-12-31

    For many years, geoscientists and engineers have undertaken research to characterize naturally fractured reservoirs. Geoscientists have focused on understanding the process of fracturing and the subsequent measurement and description of fracture characteristics. Engineers have concentrated on the fluid flow behavior in the fracture-porous media system and the development of models to predict the hydrocarbon production from these complex systems. This research attempts to integrate these two complementary views to develop a quantitative reservoir characterization methodology and flow performance model for naturally fractured reservoirs. The research has focused on estimating naturally fractured reservoir properties from seismic data, predicting fracture characteristics from well logs, and developing a naturally fractured reservoir simulator. It is important to develop techniques that can be applied to estimate the important parameters in predicting the performance of naturally fractured reservoirs. This project proposes a method to relate seismic properties to the elastic compliance and permeability of the reservoir based upon a sugar cube model. In addition, methods are presented to use conventional well logs to estimate localized fracture information for reservoir characterization purposes. The ability to estimate fracture information from conventional well logs is very important in older wells where data are often limited. Finally, a desktop naturally fractured reservoir simulator has been developed for the purpose of predicting the performance of these complex reservoirs. The simulator incorporates vertical and horizontal wellbore models, methods to handle matrix to fracture fluid transfer, and fracture permeability tensors. This research project has developed methods to characterize and study the performance of naturally fractured reservoirs that integrate geoscience and engineering data. This is an important step in developing exploitation strategies for

  11. Ethanol production by recombinant and natural xylose-utilising yeasts

    Energy Technology Data Exchange (ETDEWEB)

    Eliasson, Anna

    2000-07-01

    The xylose-fermenting capacity of recombinant Saccharomyces cerevisiae carrying XYL1 and XYL2 from Pichia stipitis, which encode xylose reductase (XR) and xylitol dehydrogenase (XDH), respectively, is poor due to high xylitol formation. Whereas, P. stipitis exhibits high ethanol yield on xylose, the tolerance towards inhibitors in the lignocellulosic hydrolysate is low. A recombinant strain possessing the advantageous characteristics of both S. cerevisiae and P. stipitis would constitute a biocatalyst capable of efficient ethanol production from lignocellulosic hydrolysate. In the work presented in this thesis, factors influencing xylose fermentation in recombinant S. cerevisiae and in the natural xylose-fermenting yeast P. stipitis have been identified and investigated. Anaerobic xylulose fermentation was compared in strains of Zygosaccharomyces and S. cerevisiae, mutants and wild-type strains to identify host strain background and genetic modifications beneficial for xylose fermentation. The greatest positive effect was found for over-expression of the gene XKS1 for the pentose phosphate pathway (PPP) enzyme xylulokinase (XK), which increased the ethanol yield by almost 85%. The Zygosaccharomyces strains tested formed large amounts of polyols, making them unsuitable as host strains. The XR/XDH/XK ratio was found to determine whether carbon accumulated in a xylitol pool or was further utilised for ethanol production in recombinant xylose-utilising S. cerevisiae. Simulations, based on a kinetic model, and anaerobic xylose cultivation experiments implied that a 1:{>=}10:{>=}4 relation was optimal in minimising xylitol formation. Ethanol formation increased with decreasing XR/XDH ratio, whereas xylitol formation decreased and XK overexpression was necessary for adequate ethanol formation. Based on the knowledge of optimal enzyme ratios, a stable, xylose-utilising strain, S. cerevisiae TMB 3001, was constructed by chromosomal integration of the XYL1 and XYL2 genes

  12. Analysis and research on natural circulation capacity of HFETR

    International Nuclear Information System (INIS)

    Xu Taozhong; Duan Tianyuan

    2010-01-01

    For the operating characteristics of HFETR, the numerical model of HFETR was established by RELAP5/MOD3 to analysis the maximal natural circulation capacity. Combining with the reactor running condition, the influence of the system pressure was analyzed by ascending power in step method and the pool water temperature on natural circulation characteristics was analyzed by integral power method. The results show that the natural circulation capacity are 0.9 and 2.0 MW separately under low pressure and high pressure, the natural circulation capacity increases as the running pressure increases, however the natural circulation capacity decreases as the coolant temperature increases in the pressure vessel. Based on the computational result and the theoretical deduction, a correlation was proposed to predicate the relationship between the natural circulation mass flow and the core power under different coolant temperatures. (authors)

  13. Umatilla Basin Natural Production Monitoring and Evaluation; 2003-2004 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, Jesse D.M.; Contor, Craig C.; Hoverson, Eric (Confederated Tribes of the Umatilla Indian Reservation, Department of Natural Resources, Pendleton, OR)

    2005-10-01

    The Umatilla Basin Natural Production Monitoring and Evaluation Project (UBNPMEP) is funded by Bonneville Power Administration (BPA) as directed by section 4(h) of the Pacific Northwest Electric Power Planning and Conservation Act of 1980 (P. L. 96-501). This project is in accordance with and pursuant to measures 4.2A, 4.3C.1, 7.1A.2, 7.1C.3, 7.1C.4 and 7.1D.2 of the Northwest Power Planning Council's (NPPC) Columbia River Basin Fish and Wildlife Program (NPPC 1994). Work was conducted by the Fisheries Program of the Confederated Tribes of the Umatilla Indian Reservation (CTUIR). UBNPMEP is coordinated with two ODFW research projects that also monitor and evaluate the success of the Umatilla Fisheries Restoration Plan. Our project deals with the natural production component of the plan, and the ODFW projects evaluate hatchery operations (project No. 19000500, Umatilla Hatchery M & E) and smolt outmigration (project No. 198902401, Evaluation of Juvenile Salmonid Outmigration and Survival in the Lower Umatilla River). Collectively these three projects comprehensively monitor and evaluate natural and hatchery salmonid production in the Umatilla River Basin. Table 1 outlines relationships with other BPA supported projects. The need for natural production monitoring has been identified in multiple planning documents including Wy-Kan-Ush-Mi Wa-Kish-Wit Volume I, 5b-13 (CRITFC 1996), the Umatilla Hatchery Master Plan (CTUIR & ODFW 1990), the Umatilla Basin Annual Operation Plan (ODFW and CTUIR 2004), the Umatilla Subbasin Summary (CTUIR & ODFW 2001), the Subbasin Plan (CTUIR & ODFW 2004), and the Comprehensive Research, Monitoring, and Evaluation Plan (Schwartz & Cameron Under Revision). Natural production monitoring and evaluation is also consistent with Section III, Basinwide Provisions, Strategy 9 of the 2000 Columbia River Basin Fish and Wildlife Program (NPPC 1994, NPPC 2004). The need for monitoring the natural production of salmonids in the Umatilla River

  14. Enhancing Environmental Communication and Products Through Qualitative Research

    Science.gov (United States)

    DeLorme, D.; Hagen, S. C.

    2014-12-01

    This presentation discusses two ongoing interdisciplinary case studies that are using qualitative research to design and enhance environmental communication and science products for outreach and decision making purposes. Both cases demonstrate the viability and practical value of qualitative social science methodology, specifically focus group interviews, to better understand the viewpoints of target audiences, improve deliverables, and support project goals. The first case is a NOAA-funded project to conduct process-based modeling to project impact from climate change in general and sea level rise in particular to the natural and built environment. The project spans the Mississippi, Alabama, and Florida Panhandle coasts with concentration on the three National Estuarine Research Reserves. As part of the broader project, four annual focus groups were conducted with a purposive sample of coastal resource managers to capture their perspectives and suggestions to better meet their informational and operational needs. The second case is a Florida Sea Grant-funded project that is developing, implementing, and testing a cohesive outreach campaign to promote voluntary careful and responsible recreational boating to help protect sensitive marine life and habitats (especially seagrasses and oyster reefs) in the Mosquito Lagoon. Six focus groups were conducted with a purposive sample of the target audience of boaters to gain insights, feedback, and ideas on the direction of the campaign and design of the messages and products. The campaign materials created include a branded website, Facebook page, mobile app, information packets, brochures, pledge forms, and promotional items. A comparison of these two case studies will be provided and will explain how the qualitative findings were/are being implemented to tailor and refine the respective communication strategies and techniques including the emerging outreach products. The resulting outcomes are messages and tools that are

  15. Deposits of naturally occurring radioactivity in production of oil and natural gas; Radioaktive avleiringer i olje- og gassproduksjon

    Energy Technology Data Exchange (ETDEWEB)

    Strand, T; Lysebo, I; Kristensen, D; Birovljev, A

    1997-01-01

    Deposits of naturally occurring radioactive materials is an increasing problem in Norwegian oil and gas production. Activity concentration in solid-state samples and production water, and doses to workers involved in different operations off-shore, have been measured. The report also includes a discussion of different methods of monitoring and alternatives for final disposal of wastes. 154 refs.

  16. North American long-term soil productivity research program

    Science.gov (United States)

    Allan E. Tiarks; Robert F. Powers; Jerry F. Ragus; Deborah S. Page-Dumroese; Felix Ponder; Douglas M. Stone

    1997-01-01

    The National Long-term Soil Productivity research program was chartered to address National Forest Management Act concerns over possible losses n soil productivity on national forest lands. The program supports validation of soil quality monitoring standards and process-level productivity research. Summarized results are supplied to forests as collected. National...

  17. Unconventional natural gas development and public health: toward a community-informed research agenda

    Science.gov (United States)

    Korfmacher, Katrina Smith; Elam, Sarah; Gray, Kathleen M.; Haynes, Erin; Hughes, Megan Hoert

    2015-01-01

    Unconventional natural gas development (UNGD) using high-volume horizontal hydraulic fracturing (“fracking”) has vastly increased the potential for domestic natural gas production in recent years. However, the rapid expansion of UNGD has also raised concerns about its potential impacts on public health. Academics and government agencies are developing research programs to explore these concerns. Community involvement in activities such as planning, conducting, and communicating research is widely recognized as having an important role in promoting environmental health. Historically, however, communities most often engage in research after environmental health concerns have emerged. This community information needs assessment took a prospective approach to integrating community leaders' knowledge, perceptions, and concerns into the research agenda prior to initiation of local UNGD. We interviewed community leaders about their views on environmental health information needs in three states (New York, North Carolina, and Ohio) prior to widespread UNGD. Interviewees emphasized the cumulative, long-term, and indirect determinants of health, as opposed to specific disease outcomes. Responses focused not only on information needs, but also on communication and transparency with respect to research processes and funding. Interviewees also prioritized investigation of policy approaches to effectively protect human health over the long term. Although universities were most often cited as a credible source of information, interviewees emphasized the need for multiple strategies for disseminating information. By including community leaders' concerns, insights, and questions from the outset, the research agenda on UNGD is more likely to effectively inform decision making that ultimately protects public health. PMID:25204212

  18. NATURAL PRODUCTS AS PRESERVATIVES FOR FAST GROWTH WOODS - A REVIEW

    Directory of Open Access Journals (Sweden)

    Ricardo Marques Barreiros

    2011-11-01

    Full Text Available Normal 0 21 false false false PT-BR X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Wood is a universal material, economic, historic and sustainable. The paucity of species resistant to biological degradation forced man to use other less durable, especially fast growing, from reforestation, as some species of Eucalyptus and Pinus. These species have moderate or no resistance to wood decay organisms need special treatment and preservatives. The products currently used preservatives are highly toxic and are potential environmental hazards and human health. Thus, there is a growing need to develop effective chemicals, non-toxic to humans and the environment. The direction of research has aimed to develop environmentally friendly products and economic viability, and an alternative is the use of Crude Tall Oil (CTO, which is a waste processing coniferous softwood pulp for the production of kraft paper. The tall oil as a protective agent, has been considered a promising method for significantly reducing the capillary water absorption of sapwood, thereby removing one of the factors that favor the wood being attacked by fungi and insects: water, oxygen and nutrients. Research shows that the tall oil can be used neat, either fresh or distilled, or in combination with biocides.A madeira é um material universal, econ

  19. Research Progress of Natural Product Gentiopicroside - a Secoiridoid Compound.

    Science.gov (United States)

    Wu, Shaoping; Ning, Yaoyao; Zhao, Yingyong; Sun, Wenji; Thorimbert, Serge; Dechoux, Luc; Sollogoub, Matthieu; Zhang, Yongmin

    2017-01-01

    Gentiopicroside is a secoiridoid compound isolated from Gentiana lutea which is called Qin Jiao in Chinese. It is one of the most common herbal medicines used in China. In this article, we review the pharmacological and biological activity (antiviral, anti-inflammatory, analgesia, antihepatotoxic and choleretic), as well as biotransformation of the gentiopicroside. In addition, attempt towards the total synthesis of gentiopicroside is also presented.

  20. Next Generation Sequencing of Actinobacteria for the Discovery of Novel Natural Products

    Science.gov (United States)

    Gomez-Escribano, Juan Pablo; Alt, Silke; Bibb, Mervyn J.

    2016-01-01

    Like many fields of the biosciences, actinomycete natural products research has been revolutionised by next-generation DNA sequencing (NGS). Hundreds of new genome sequences from actinobacteria are made public every year, many of them as a result of projects aimed at identifying new natural products and their biosynthetic pathways through genome mining. Advances in these technologies in the last five years have meant not only a reduction in the cost of whole genome sequencing, but also a substantial increase in the quality of the data, having moved from obtaining a draft genome sequence comprised of several hundred short contigs, sometimes of doubtful reliability, to the possibility of obtaining an almost complete and accurate chromosome sequence in a single contig, allowing a detailed study of gene clusters and the design of strategies for refactoring and full gene cluster synthesis. The impact that these technologies are having in the discovery and study of natural products from actinobacteria, including those from the marine environment, is only starting to be realised. In this review we provide a historical perspective of the field, analyse the strengths and limitations of the most relevant technologies, and share the insights acquired during our genome mining projects. PMID:27089350

  1. High folate production by naturally occurring Lactobacillus sp. with ...

    African Journals Online (AJOL)

    African Journal of Biotechnology. Journal Home ... Milk products are good sources of such vitamins which are produced by probiotics. In order to ... Therefore, two new strains with an ability of high folate production were isolated and identified.

  2. Use of natural zeolite-supplemented litter increased broiler production

    African Journals Online (AJOL)

    smyo

    aimed at elucidating the effects of combinations of these products as litter on poultry production, such as .... The bulbs on the ceiling were used ... sample, curved fibrous and acicular mordenites were derived from volcanic glass (Figure 2b).

  3. Pilot Scale Production of Irradiated Natural Rubber Latex and its Dipping Products

    Directory of Open Access Journals (Sweden)

    M. Utama

    2005-07-01

    Full Text Available One hundred and fifty kg natural rubber latex (NRL before and after concentration were added with 3 phr (part hundred ratio of rubber normal butyl acrylate, then the mixture were irradiated at 25 kGy by gamma rays of 60Co in pilot scale. The irradiated natural rubber latex (INRL were then being to use for producing rubber products such as condom, surgical gloves, and spygmomanometer in factory scale. The quality of INRL and rubber products such as : total solid content (TSC, dry rubber content (DRC, KOH, VFA and MST number, tensile strength, modulus, elongation at break, extractable protein content, and response against Type I allergy etc. were evaluated. The economic aspect for producing INRL by means of Gamma Irradiator (GI and Electron Beam Machine (EBM such as payback period (PP, net present value (NPV and internal rate return (IRR were calculated. The results showed that the latex properties of INRL such as DRC, TSC, KOH, VFA, and MST number are not only found to the requirement of the ISO 2004 standard but also the latex has low protein, lipid, and carbohydrate content. The physical and mechanical properties (tensile strength, modulus, and elongation at break of rubber dipping products such as condom, gloves, and sphygmomanometer are not only found to the requirement of ISO 4074, ISO 10282, and ANSI/AAMI SP-1994 standards, but also the allergic response tested clinical latex-sensitive protein allergen by ELISA test on gloves, and by SPT test on condom are found to be negative. It indicates that production of INRL or PVNRL or RVNRL by EBM 250 keV/10 mA, was more cheap than by using gamma γ irradiator 200 kCi, or sulfur vulcanization. The value of PBP (payback period was 2,1 years, NPV (net present value was 4,250 US $, PI (profitability index 1,06 and IRR (internal rate of returns was 25,0%.

  4. The Nature of Practitioner Research: Critical Distance, Power and Ethics

    Science.gov (United States)

    Appleby, Michelle M.

    2013-01-01

    Researching within one's place of practice allows the researcher to have the unique position of knowing the participants and the research context. The relationship the participants have with the researcher will impact upon the disclosure of information differently than research conducted by someone outside the area of practice. This can be a…

  5. Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production.

    Science.gov (United States)

    Liu, Xiaonan; Ding, Wentao; Jiang, Huifeng

    2017-07-19

    Plant natural products (PNPs) are widely used as pharmaceuticals, nutraceuticals, seasonings, pigments, etc., with a huge commercial value on the global market. However, most of these PNPs are still being extracted from plants. A resource-conserving and environment-friendly synthesis route for PNPs that utilizes microbial cell factories has attracted increasing attention since the 1940s. However, at the present only a handful of PNPs are being produced by microbial cell factories at an industrial scale, and there are still many challenges in their large-scale application. One of the challenges is that most biosynthetic pathways of PNPs are still unknown, which largely limits the number of candidate PNPs for heterologous microbial production. Another challenge is that the metabolic fluxes toward the target products in microbial hosts are often hindered by poor precursor supply, low catalytic activity of enzymes and obstructed product transport. Consequently, despite intensive studies on the metabolic engineering of microbial hosts, the fermentation costs of most heterologously produced PNPs are still too high for industrial-scale production. In this paper, we review several aspects of PNP production in microbial cell factories, including important design principles and recent progress in pathway mining and metabolic engineering. In addition, implemented cases of industrial-scale production of PNPs in microbial cell factories are also highlighted.

  6. Natural personal care products-analysis of ingredient lists and legal situation.

    Science.gov (United States)

    Klaschka, Ursula

    2016-01-01

    Many natural substances are classified as dangerous substances according to the European regulation on classification and labelling. Are they used in natural personal care products today? One hundred ingredient lists were analyzed to find this out. All products with natural substances contained dangerous natural substances or they contained natural substances, for which the information about their classification as dangerous substances is not available. 54 natural substances quoted in the ingredient lists were found to be classified, with 37 substances being classified due to hazardous effects for skin and eyes. However, the most frequently used natural substances are not classified as dangerous. Natural substances are multi-constituent compounds, leading to two main problems in personal care products: the potential interactions of a multitude of substances and the fact that dangerous constituents are not disclosed in the ingredient lists. For example, the fragrance allergens citral, farnesol, limonene, and linalool are frequent components of the natural substances employed. In addition, 82 products listed allergenic fragrance ingredients as single substances in their ingredient lists. Recommendations for sensitive skin in a product's name do not imply that the '26 fragrance allergens' are omitted. Furthermore, 80 products listed 'parfum'/'aroma', and 50 products listed ethanol. The data show that the loopholes for natural substances and for personal care products in the present European chemical legislation (e.g. the exception for classification and labelling of cosmetic products and the exception for information transfer in the supply chain) are not in line with an adequate consumer and environmental protection.

  7. Comparative analysis of chemical similarity methods for modular natural products with a hypothetical structure enumeration algorithm.

    Science.gov (United States)

    Skinnider, Michael A; Dejong, Chris A; Franczak, Brian C; McNicholas, Paul D; Magarvey, Nathan A

    2017-08-16

    Natural products represent a prominent source of pharmaceutically and industrially important agents. Calculating the chemical similarity of two molecules is a central task in cheminformatics, with applications at multiple stages of the drug discovery pipeline. Quantifying the similarity of natural products is a particularly important problem, as the biological activities of these molecules have been extensively optimized by natural selection. The large and structurally complex scaffolds of natural products distinguish their physical and chemical properties from those of synthetic compounds. However, no analysis of the performance of existing methods for molecular similarity calculation specific to natural products has been reported to date. Here, we present LEMONS, an algorithm for the enumeration of hypothetical modular natural product structures. We leverage this algorithm to conduct a comparative analysis of molecular similarity methods within the unique chemical space occupied by modular natural products using controlled synthetic data, and comprehensively investigate the impact of diverse biosynthetic parameters on similarity search. We additionally investigate a recently described algorithm for natural product retrobiosynthesis and alignment, and find that when rule-based retrobiosynthesis can be applied, this approach outperforms conventional two-dimensional fingerprints, suggesting it may represent a valuable approach for the targeted exploration of natural product chemical space and microbial genome mining. Our open-source algorithm is an extensible method of enumerating hypothetical natural product structures with diverse potential applications in bioinformatics.

  8. Product Design: Research Trends and an Agenda for the Future

    NARCIS (Netherlands)

    Di Benedetto, A.C.

    2012-01-01

    Academic research in product design is growing in popular- ity, and new challenging research questions are emerging. This article explores several of these product design research issues. We first explore the role of design as a driver of innovation and as a strategic resource to senior managers for

  9. An Analysis of Female Research Productivity in Nigerian Universities

    Science.gov (United States)

    Ogbogu, Christiana O.

    2009-01-01

    This study examines the research output of female staff and the factors that affect their research productivity in the Nigerian university system. The study was carried out with a view to promoting strategies that will enhance productivity and increase the research output of female staff in Nigerian universities. The study adopted a survey…

  10. Implementation of Research and Development Based on Patent Natural Ingredients and Potential Utilization of Tradition Medicine

    Directory of Open Access Journals (Sweden)

    Tommy Hendrix

    2016-12-01

    Full Text Available The results of research and development based on natural ingredients for traditional medicines become an interesting topic to discuss at this point; it’s shown from increasing number in utilization. The use of traditional medicine especially on natural ingredients at this moment becomes effective solution to increase the level of market acceptance in herbal extracts, including an affordable purchase from potential utilization of natural resources which are owned. By using Matheo Patent XE Ver 10.2 as methodology of searching, we can know potentials useful through strategy, research and development, patent analysis and patent collaboration among users in utilization of Natural Ingredient for Traditional Medicine. From the data result shows majority in the field of chemistry for human necessity related to Health; Amusement; Medical or Veterinary Science; Hygiene sectors with total patent 108, family 65. The use of patent analysis is a way to find how the development of technology and products that have been produced and how commercial processes connecting with technology users, especially in traditional medicine. From the data that exist in particular of patents, it is critical to identify the number of patents that has been registered through the innovation process development including technology dissemination is used.

  11. Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries.

    Science.gov (United States)

    Lee, M L; Schneider, G

    2001-01-01

    Natural products were analyzed to determine whether they contain appealing novel scaffold architectures for potential use in combinatorial chemistry. Ring systems were extracted and clustered on the basis of structural similarity. Several such potential scaffolds for combinatorial chemistry were identified that are not present in current trade drugs. For one of these scaffolds a virtual combinatorial library was generated. Pharmacophoric properties of natural products, trade drugs, and the virtual combinatorial library were assessed using a self-organizing map. Obviously, current trade drugs and natural products have several topological pharmacophore patterns in common. These features can be systematically explored with selected combinatorial libraries based on a combination of natural product-derived and synthetic molecular building blocks.

  12. Textbook for nature entrepreneurship : product of the WURKS project Nature Entrepreneurship and Tourism within Green Education (NatureToGo)

    NARCIS (Netherlands)

    Felder, M.; Pellis, A.

    2013-01-01

    In recent years, government funding for nature conservation and development has declined. As a result, links between nature conservation and entrepreneurship are increasingly being made in both practice and education. This comes with many questions and challenges. In Green Secondary Vocational

  13. Process for decontamination of surfaces in an facility of natural uranium hexafluoride production (UF6)

    International Nuclear Information System (INIS)

    Almeida, Claudio C. de; Silva, Teresinha M.; Rodrigues, Demerval L.; Carneiro, Janete C.G.G.

    2017-01-01

    The experience acquired in the actions taken during the decontamination process of an IPEN-CNEN / SP Nuclear and Energy Research Institute facility, for the purpose of making the site unrestricted, is reported. The steps of this operation involved: planning, training of facility operators, workplace analysis and radiometric measurements. The facility had several types of equipment from the natural uranium hexafluoride (UF 6 ) production tower and other facility materials. Rules for the transportation of radioactive materials were established, both inside and outside the facility and release of materials and installation

  14. Products of steel slags an opportunity to save natural resources.

    Science.gov (United States)

    Motz, H; Geiseler, J

    2001-01-01

    In Germany, and in the most industrial countries, the use of blast furnace and steel slags as an aggregate for civil engineering, for metallurgical use and as fertiliser has a very long tradition. Since the introduction of the basic oxygen steel making furnace (BOF) process and the electric arc furnace (EAF) process the German steel industry started extensive research on the development of fields of application for BOF and EAF slags. These investigations have been mainly performed by Forschungsgemeinschaft Eisenhüttenschlacken e. V. (FEhS), the Research Association for blast furnace and steel slags. Today steel slags are well characterised and long-term experienced materials mainly used as aggregates for road construction (e.g. asphaltic or unbound layers), as armour-stones for hydraulic engineering constructions (e.g. stabilisation of shores), and as fertiliser for agriculture purposes. These multifarious fields of application could only be achieved because the steelworks influence the quality of slags by a careful selection of raw materials and a suitable process route. Furthermore, subsequent procedures like a treatment of the liquid slag, an appropriate heat treatment and a suitable processing have been developed to ensure that the quality of steel slags is always adequate for the end use. Depending on the respective field of application, the suitability of steel slags has to be proven by determining the technical properties, as well as the environmental compatibility. For this reason test methods have been developed to evaluate the technical properties especially the volume stability and the environmental behaviour. To evaluate the volume stability a suitable test (steam test) has been developed and the results from laboratory tests were compared with the behaviour of steel slags under practical conditions, e.g. in a road. To determine the environmental behaviour leaching tests have been developed. In the meanwhile most of these test methods are drafted or

  15. Preliminary report on the economics of gas production from natural gas hydrates

    International Nuclear Information System (INIS)

    Walsh, M.; Wilson, S.; Patil, S.; Moridis, G.; Boswell, R.; Koh, C.; Sloan, D.

    2008-01-01

    Gas hydrates are solid crystalline compounds in which gas molecules reside inside cages that are formed by hydrogen-bonded water molecules in a crystal lattice. At particularly low temperatures and high pressures, a guest molecule will combine with water to form gas hydrates. Gas hydrates are found in two different settings in which the temperature and pressure conditions are suitable for their existence, notably in Arctic permafrost regions and below the seafloor. Because of the size of this possible future resource, if any of the gas in hydrates can be proven to be economically recoverable, then production from gas hydrates could become an important portion of the world's energy portfolio as demand for natural gas increases along with the technology to compress and distribute natural gas to distant markets. This paper presented a compilation of economic research that was conducted on the resource potential of gas hydrates. The paper reported a preliminary estimate of the price of natural gas that may lead to economically-viable production from North American Arctic region hydrates. The paper also discussed the implications of a recent study on the production of class 3 marine hydrate deposits from the Gulf of Mexico. The state of the art technologies and methods in hydrate reservoir modeling and hydrate reservoir production and petrophysical testing were also discussed. It was concluded that the somewhat optimistic results presented in this report should be interpreted with caution, however, the economically-viable gas production from hydrates was not an unreasonable scenario. 23 refs., 2 tabs., 10 figs

  16. Faculty research productivity and organizational structure in schools of nursing.

    Science.gov (United States)

    Kohlenberg, E M

    1992-01-01

    The purpose of this study was to identify the relationship between faculty research productivity and organizational structure in schools of nursing. The need for nursing research has been widely recognized by members of the nursing profession, yet comparatively few engage in conducting research. Although contextual variables have been investigated that facilitate or inhibit nursing research, the relationship between organizational structure and nursing research productivity has not been examined. This problem was examined within the context of the Entrepreneurial Theory of Formal Organizations. A survey methodology was used for data collection. Data on individual faculty research productivity and organizational structure in the school of nursing were obtained through the use of a questionnaire. A random sample of 300 faculty teaching in 60 master's and doctoral nursing schools in the United States was used. The instruments for data collection were Wakefield-Fisher's Adapted Scholarly Productivity Index and Hall's Organizational Inventory. The data were analyzed using Pearson Product-Moment Correlation Coefficients and multiple correlation/regression techniques. The overall relationship between faculty research productivity and organizational structure in schools of nursing was not significant at the .002 level of confidence. Although statistically significant relationships were not identified, scholarly research productivity and its subscale prepublication and research activities tended to vary positively with procedural specifications in a highly bureaucratic organizational structure. Further research may focus on identification of structural variables that support highly productive nurse researchers.

  17. Wood bioenergy and soil productivity research

    Science.gov (United States)

    D. Andrew Scott; Deborah S. Page-Dumroese

    2016-01-01

    Timber harvesting can cause both short- and long-term changes in forest ecosystem functions, and scientists from USDA Forest Service (USDA FS) have been studying these processes for many years. Biomass and bioenergy markets alter the amount, type, and frequency at which material is harvested, which in turn has similar yet specific impacts on sustainable productivity....

  18. Genome-Based Studies of Marine Microorganisms to Maximize the Diversity of Natural Products Discovery for Medical Treatments

    Directory of Open Access Journals (Sweden)

    Xin-Qing Zhao

    2011-01-01

    Full Text Available Marine microorganisms are rich source for natural products which play important roles in pharmaceutical industry. Over the past decade, genome-based studies of marine microorganisms have unveiled the tremendous diversity of the producers of natural products and also contributed to the efficiency of harness the strain diversity and chemical diversity, as well as the genetic diversity of marine microorganisms for the rapid discovery and generation of new natural products. In the meantime, genomic information retrieved from marine symbiotic microorganisms can also be employed for the discovery of new medical molecules from yet-unculturable microorganisms. In this paper, the recent progress in the genomic research of marine microorganisms is reviewed; new tools of genome mining as well as the advance in the activation of orphan pathways and metagenomic studies are summarized. Genome-based research of marine microorganisms will maximize the biodiscovery process and solve the problems of supply and sustainability of drug molecules for medical treatments.

  19. Phylogeny-guided (meta)genome mining approach for the targeted discovery of new microbial natural products.

    Science.gov (United States)

    Kang, Hahk-Soo

    2017-02-01

    Genomics-based methods are now commonplace in natural products research. A phylogeny-guided mining approach provides a means to quickly screen a large number of microbial genomes or metagenomes in search of new biosynthetic gene clusters of interest. In this approach, biosynthetic genes serve as molecular markers, and phylogenetic trees built with known and unknown marker gene sequences are used to quickly prioritize biosynthetic gene clusters for their metabolites characterization. An increase in the use of this approach has been observed for the last couple of years along with the emergence of low cost sequencing technologies. The aim of this review is to discuss the basic concept of a phylogeny-guided mining approach, and also to provide examples in which this approach was successfully applied to discover new natural products from microbial genomes and metagenomes. I believe that the phylogeny-guided mining approach will continue to play an important role in genomics-based natural products research.

  20. Nature is the best source of anti-inflammatory drugs: indexing natural products for their anti-inflammatory bioactivity.

    Science.gov (United States)

    Aswad, Miran; Rayan, Mahmoud; Abu-Lafi, Saleh; Falah, Mizied; Raiyn, Jamal; Abdallah, Ziyad; Rayan, Anwar

    2018-01-01

    The aim was to index natural products for less expensive preventive or curative anti-inflammatory therapeutic drugs. A set of 441 anti-inflammatory drugs representing the active domain and 2892 natural products representing the inactive domain was used to construct a predictive model for bioactivity-indexing purposes. The model for indexing the natural products for potential anti-inflammatory activity was constructed using the iterative stochastic elimination algorithm (ISE). ISE is capable of differentiating between active and inactive anti-inflammatory molecules. By applying the prediction model to a mix set of (active/inactive) substances, we managed to capture 38% of the anti-inflammatory drugs in the top 1% of the screened set of chemicals, yielding enrichment factor of 38. Ten natural products that scored highly as potential anti-inflammatory drug candidates are disclosed. Searching the PubMed revealed that only three molecules (Moupinamide, Capsaicin, and Hypaphorine) out of the ten were tested and reported as anti-inflammatory. The other seven phytochemicals await evaluation for their anti-inflammatory activity in wet lab. The proposed anti-inflammatory model can be utilized for the virtual screening of large chemical databases and for indexing natural products for potential anti-inflammatory activity.

  1. Informatic search strategies to discover analogues and variants of natural product archetypes.

    Science.gov (United States)

    Johnston, Chad W; Connaty, Alex D; Skinnider, Michael A; Li, Yong; Grunwald, Alyssa; Wyatt, Morgan A; Kerr, Russell G; Magarvey, Nathan A

    2016-03-01

    Natural products are a crucial source of antimicrobial agents, but reliance on low-resolution bioactivity-guided approaches has led to diminishing interest in discovery programmes. Here, we demonstrate that two in-house automated informatic platforms can be used to target classes of biologically active natural products, specifically, peptaibols. We demonstrate that mass spectrometry-based informatic approaches can be used to detect natural products with high sensitivity, identifying desired agents present in complex microbial extracts. Using our specialised software packages, we could elaborate specific branches of chemical space, uncovering new variants of trichopolyn and demonstrating a way forward in mining natural products as a valuable source of potential pharmaceutical agents.

  2. Automatic map generalisation from research to production

    Science.gov (United States)

    Nyberg, Rose; Johansson, Mikael; Zhang, Yang

    2018-05-01

    The manual work of map generalisation is known to be a complex and time consuming task. With the development of technology and societies, the demands for more flexible map products with higher quality are growing. The Swedish mapping, cadastral and land registration authority Lantmäteriet has manual production lines for databases in five different scales, 1 : 10 000 (SE10), 1 : 50 000 (SE50), 1 : 100 000 (SE100), 1 : 250 000 (SE250) and 1 : 1 million (SE1M). To streamline this work, Lantmäteriet started a project to automatically generalise geographic information. Planned timespan for the project is 2015-2022. Below the project background together with the methods for the automatic generalisation are described. The paper is completed with a description of results and conclusions.

  3. Plants and other natural products used in the management of oral infections and improvement of oral health.

    Science.gov (United States)

    Chinsembu, Kazhila C

    2016-02-01

    Challenges of resistance to synthetic antimicrobials have opened new vistas in the search for natural products. This article rigorously reviews plants and other natural products used in oral health: Punica granatum L. (pomegranate), Matricaria recutita L. (chamomile), Camellia sinensis (L.) Kuntze (green tea), chewing sticks made from Diospyros mespiliformis Hochst. ex A.D.C., Diospyros lycioides Desf., and Salvadora persica L. (miswak), honey and propolis from the manuka tree (Leptospermum scoparium J.R. Forst. & G. Forst.), rhein from Rheum rhabarbarum L. (rhubarb), dried fruits of Vitis vinifera L. (raisins), essential oils, probiotics and mushrooms. Further, the review highlights plants from Africa, Asia, Brazil, Mexico, Europe, and the Middle East. Some of the plants' antimicrobial properties and chemical principles have been elucidated. While the use of natural products for oral health is prominent in resource-poor settings, antimicrobial testing is mainly conducted in the following countries (in decreasing order of magnitude): India, South Africa, Brazil, Japan, France, Egypt, Iran, Mexico, Kenya, Switzerland, Nigeria, Australia, Uganda, and the United Kingdom. While the review exposes a dire gap for more studies on clinical efficacy and toxicity, the following emerging trend was noted: basic research on plants for oral health is mainly done in Brazil, Europe and Australia. Brazil, China, India and New Zealand generally conduct value addition of natural products for fortification of toothpastes. African countries focus on bioprospecting and primary production of raw plants and other natural products with antimicrobial efficacies. The Middle East and Egypt predominantly research on plants used as chewing sticks. More research and funding are needed in the field of natural products for oral health, especially in Africa where oral diseases are fuelled by human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Copyright © 2015 Elsevier B

  4. Productivity Research and Development Planning Workshop.

    Science.gov (United States)

    1986-03-01

    mission. These ideas must come from everyone in all echelons of the Comand. The MAC quality of worklife efforts consist of quality circles, labor-manage...that would not have been captured by the measure as initially formulated by the PIG. The balance of the plan and recommenda- tions made by the PMWG...people are doing things. We have the suggestion program, the quality of worklife program, and the Tech Mod program. All of these programs are productivity

  5. Sources of Research Ideas Among Productive Scholars. Implications for Administrators

    Science.gov (United States)

    Glueck, William F.; Jauch, Lawrence R.

    1975-01-01

    Administrators wishing to stimulate research productivity should try to lure the most creative researchers but should also put emphasis on libraries and information retrieval services, and funds to attend professional meetings. (Editor)

  6. Electrocatalysis research for fuel cells and hydrogen production

    CSIR Research Space (South Africa)

    Mathe, MK

    2012-01-01

    Full Text Available The CSIR undertakes research in the Electrocatalysis of fuel cells and for hydrogen production. The Hydrogen South Africa (HySA) strategy supports research on electrocatalysts due to their importance to the national beneficiation strategy. The work...

  7. The effective management of medical isotope production in research reactors

    International Nuclear Information System (INIS)

    Drummond, D.T.

    1993-01-01

    During the 50-yr history of the use of radioisotopes for medical applications, research reactors have played a pivotal role in the production of many if not most of the key products. The marriage between research reactors and production operations is subject to significant challenges on two fronts. The medical applications of the radioisotope products impose some unique constraints and requirements on the production process. In addition, the mandates and priorities of a research reactor are not always congruent with the demands of a production environment. This paper briefly reviews the historical development of medical isotope production, identifies the unique challenges facing this endeavor, and discusses the management of the relationship between the isotope producer and the research reactor operator. Finally, the key elements of a successful relationship are identified

  8. Animal Production Research Advances: Advanced Search

    African Journals Online (AJOL)

    Search tips: Search terms are case-insensitive; Common words are ignored; By default only articles containing all terms in the query are returned (i.e., AND is implied); Combine multiple words with OR to find articles containing either term; e.g., education OR research; Use parentheses to create more complex queries; e.g., ...

  9. Plant Products Research Journal: Advanced Search

    African Journals Online (AJOL)

    Search tips: Search terms are case-insensitive; Common words are ignored; By default only articles containing all terms in the query are returned (i.e., AND is implied); Combine multiple words with OR to find articles containing either term; e.g., education OR research; Use parentheses to create more complex queries; e.g., ...

  10. Using market research for product line development.

    Science.gov (United States)

    Bowie, B H; Kivney, N

    1993-08-01

    A marketing research study determined patient needs and wants in order to tailor services within a family maternity care unit. In addition, an educational program, implemented in an effort to change the behavior of the caregivers in the clinical area, is described.

  11. Supercritical water natural circulation flow stability experiment research

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Dongliang; Zhou, Tao; Li, Bing [North China Electric Power Univ., Beijing (China). School of Nuclear Science and Engineering; North China Electric Power Univ., Beijing (China). Inst. of Nuclear Thermalhydraulic Safety and Standardization; North China Electric Power Univ., Beijing (China). Beijing Key Lab. of Passive Safety Technology for Nuclear Energy; Huang, Yanping [Nuclear Power Institute of China, Chengdu (China). Science and Technology on Reactor System Design Technology Lab.

    2017-12-15

    The Thermal hydraulic characteristics of supercritical water natural circulation plays an important role in the safety of the Generation-IV supercritical water-cooled reactors. Hence it is crucial to conduct the natural circulation heat transfer experiment of supercritical water. The heat transfer characteristics have been studied under different system pressures in the natural circulation systems. Results show that the fluctuations in the subcritical flow rate (for natural circulation) is relatively small, as compared to the supercritical flow rate. By increasing the heating power, it is observed that the amplitude (and time period) of the fluctuation tends to become larger for the natural circulation of supercritical water. This tends to show the presence of flow instability in the supercritical water. It is possible to observe the flow instability phenomenon when the system pressure is suddenly reduced from the supercritical pressure state to the subcritical state. At the test outlet section, the temperature is prone to increase suddenly, whereas the blocking effect may be observed in the inlet section of the experiment.

  12. 7 CFR 917.39 - Production research, market research and development.

    Science.gov (United States)

    2010-01-01

    ... establish or provide for the establishment of production research, marketing research, and development... 7 Agriculture 8 2010-01-01 2010-01-01 false Production research, market research and development...) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF...

  13. 7 CFR 925.45 - Production research and market research and development.

    Science.gov (United States)

    2010-01-01

    ... Secretary, may establish or provide for the establishment of production research, marketing research and... 7 Agriculture 8 2010-01-01 2010-01-01 false Production research and market research and...) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF...

  14. Federal research natural areas in Oregon and Washington: a guidebook for scientists and educators.

    Science.gov (United States)

    Jerry F. Franklin; Fredrick C. Hall; C. T. Dyrness; Chris. Maser

    1972-01-01

    A guide to the use of natural scientific preserves, Research Natural Areas, on Federal lands in Oregon and Washington. Detailed descriptions of physical and biological features, maps and photographs are provided for each of the 45 tracts presently reserved. Indices to Research Natural Areas by vegetation type and plant and mammalian species are included.

  15. Voracious transformation of a common natural resource into productive capital

    NARCIS (Netherlands)

    van der Ploeg, F.

    2010-01-01

    I analyze a power struggle where competing factions have private financial assets and deplete a common stock of natural resources with no private property rights. I obtain a feedback Nash equilibrium to the dynamic common-pool problem and obtain political variants of the Hotelling depletion rule and

  16. Use of natural zeolite-supplemented litter increased broiler production

    African Journals Online (AJOL)

    The aim of this study was to ascertain the influence of natural zeolite, consisting mainly of clinoptilolite and mordenite, as a component of the litter material in broiler houses on the performance of the broilers and on some litter characteristics. Live weight gain, feed consumption, feed efficiency, viability and leg and body ...

  17. Nature Relation Between Climatic Variables and Cotton Production

    Directory of Open Access Journals (Sweden)

    Zakaria M. Sawan

    2014-08-01

    Full Text Available This study investigated the effect of climatic variables on flower and boll production and retention in cotton (Gossypium barbadense. Also, this study investigated the relationship between climatic factors and production of flowers and bolls obtained during the development periods of the flowering and boll stage, and to determine the most representative period corresponding to the overall crop pattern. Evaporation, sunshine duration, relative humidity, surface soil temperature at 1800 h, and maximum air temperature, are the important climatic factors that significantly affect flower and boll production. The least important variables were found to be surface soil temperature at 0600 h and minimum temperature. There was a negative correlation between flower and boll production and either evaporation or sunshine duration, while that correlation with minimum relative humidity was positive. Higher minimum relative humidity, short period of sunshine duration, and low temperatures enhanced flower and boll formation.

  18. High folate production by naturally occurring Lactobacillus sp. with ...

    African Journals Online (AJOL)

    USER

    2010-08-16

    Aug 16, 2010 ... high folate production, isolation and identification of Lactobacilli in traditional fermented milk ... mended for pregnant women (Van Der Put et al., 2001; ...... utilization of folic acid and vitamin B12 by lactic cultures in skim milk.

  19. The Umatilla Basin Natural Production Monitoring and Evaluation Project, 2008 Annual Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Contor, Craig R.; Harris, Robin; King, Marty [Confederated Tribes of the Umatilla Indian Reservation

    2009-06-10

    The Umatilla Basin Natural Production Monitoring and Evaluation Project (UBNPMEP) is funded by Bonneville Power Administration (BPA) as directed by section 4(h) of the Pacific Northwest Electric Power Planning and Conservation Act of 1980 (P.L.96-501). This project is in accordance with and pursuant to measures 4.2A, 4.3C.1, 7.1A.2, 7.1C.3, 7.1C.4 and 7.1D.2 of the Northwest Power Planning Council's (NPPC) Columbia River Basin Fish and Wildlife Program (NPPC 1994). Work was conducted by the Fisheries Program of the Confederated Tribes of the Umatilla Indian Reservation (CTUIR). The UBNPMEP is coordinated with two Oregon Department of Fish and Wildlife (ODFW) research projects that also monitor and evaluate the success of the Umatilla Fisheries Restoration Plan. This project deals with the natural production component of the plan, and the ODFW projects evaluate hatchery operations (project No. 1990-005-00, Umatilla Hatchery M & E) and smolt outmigration (project No. 1989-024-01, Evaluation of Juvenile Salmonid Outmigration and Survival in the Lower Umatilla River). Collectively these three projects monitor and evaluate natural and hatchery salmonid production in the Umatilla River Basin. The need for natural production monitoring has been identified in multiple planning documents including Wy-Kan-Ush-Mi Wa-Kish-Wit Volume I, 5b-13 (CRITFC 1996), the Umatilla Hatchery Master Plan (CTUIR & ODFW 1990), the Umatilla Basin Annual Operation Plan, the Umatilla Subbasin Summary (CTUIR & ODFW 2001), the Subbasin Plan (CTUIR & ODFW 2004), and the Comprehensive Research, Monitoring, and Evaluation Plan (CTUIR and ODFW 2006). Natural production monitoring and evaluation is also consistent with Section III, Basinwide Provisions, Strategy 9 of the 2000 Columbia River Basin Fish and Wildlife Program (NPPC 1994, NPCC 2004). The Umatilla Basin M&E plan developed along with efforts to restore natural populations of spring and fall Chinook salmon, (Oncorhynchus tshawytsha), coho

  20. Data publication activities in the Natural Environment Research Council

    Science.gov (United States)

    Leadbetter, A.; Callaghan, S.; Lowry, R.; Moncoiffé, G.; Donnegan, S.; Pepler, S.; Cunningham, N.; Kirsch, P.; Ault, L.; Bell, P.; Bowie, R.; Harrison, K.; Smith-Haddon, B.; Wetherby, A.; Wright, D.; Thorley, M.

    2012-04-01

    The Natural Environment Research Council (NERC) is implementing its Science Information Strategy in order to provide a world class service to deliver integrated data for earth system science. One project within this strategy is Data Citation and Publication, which aims to put the promotion and recognition stages of the data lifecycle into place alongside the traditional data management activities of NERC's Environmental Data Centres (EDCs). The NERC EDCs have made a distinction between the serving of data and its publication. Data serving is defined in this case as the day-to-day data management tasks of: • acquiring data and metadata from the originating scientists; • metadata and format harmonisation prior to database ingestion; • ensuring the metadata is adequate and accurate and that the data are available in appropriate file formats; • and making the data available for interested parties. Whereas publication: • requires the assignment of a digital object identifier to a dataset which guarantees that an EDC has assessed the quality of the metadata and the file format and will maintain an unchanged version of the data for the foreseeable future • requires the peer-review of the scientific quality of the data by a scientist with knowledge of the scientific domain in which the data were collected, using a framework for peer-review of datasets such as that developed by the CLADDIER project. • requires collaboration with journal publishers who have access to a well established peer-review system The first of these requirements can be managed in-house by the EDCs, while the remainder require collaboration with the wider scientific and publishing communities. It is anticipated that a scientist may achieve a lower level of academic credit for a dataset which is assigned a DOI but does not follow through to the scientific peer-review stage, similar to publication in a report or other non-peer reviewed publication normally described as grey literature, or

  1. Research on Digital Product Modeling Key Technologies of Digital Manufacturing

    Institute of Scientific and Technical Information of China (English)

    DING Guoping; ZHOU Zude; HU Yefa; ZHAO Liang

    2006-01-01

    With the globalization and diversification of the market and the rapid development of Information Technology (IT) and Artificial Intelligence (AI), the digital revolution of manufacturing is coming. One of the key technologies in digital manufacturing is product digital modeling. This paper firstly analyzes the information and features of the product digital model during each stage in the product whole lifecycle, then researches on the three critical technologies of digital modeling in digital manufacturing-product modeling, standard for the exchange of product model data and digital product data management. And the potential signification of the product digital model during the process of digital manufacturing is concluded-product digital model integrates primary features of each stage during the product whole lifecycle based on graphic features, applies STEP as data exchange mechanism, and establishes PDM system to manage the large amount, complicated and dynamic product data to implement the product digital model data exchange, sharing and integration.

  2. Natural Gas and Cellulosic Biomass: A Clean Fuel Combination? Determining the Natural Gas Blending Wall in Biofuel Production.

    Science.gov (United States)

    M Wright, Mark; Seifkar, Navid; Green, William H; Román-Leshkov, Yuriy

    2015-07-07

    Natural gas has the potential to increase the biofuel production output by combining gas- and biomass-to-liquids (GBTL) processes followed by naphtha and diesel fuel synthesis via Fischer-Tropsch (FT). This study reflects on the use of commercial-ready configurations of GBTL technologies and the environmental impact of enhancing biofuels with natural gas. The autothermal and steam-methane reforming processes for natural gas conversion and the gasification of biomass for FT fuel synthesis are modeled to estimate system well-to-wheel emissions and compare them to limits established by U.S. renewable fuel mandates. We show that natural gas can enhance FT biofuel production by reducing the need for water-gas shift (WGS) of biomass-derived syngas to achieve appropriate H2/CO ratios. Specifically, fuel yields are increased from less than 60 gallons per ton to over 100 gallons per ton with increasing natural gas input. However, GBTL facilities would need to limit natural gas use to less than 19.1% on a LHV energy basis (7.83 wt %) to avoid exceeding the emissions limits established by the Renewable Fuels Standard (RFS2) for clean, advanced biofuels. This effectively constitutes a blending limit that constrains the use of natural gas for enhancing the biomass-to-liquids (BTL) process.

  3. Research in Knowledge Representation for Natural Language Understanding

    Science.gov (United States)

    1983-10-01

    how a Concept specializes its subsumer. |C|ANIMAL. |C|PLANT. |C(PERSON, and |C| UNICORN are natural kinds, and so will need a PrimitiveClass. As...build this proof, we must build a proof of p x (p X n) steps. The size of the proofs grows exponentially with the depth of nesting This :s clearly

  4. The participation of the production sector in the research projects financed by CTPETRO - National Brazilian Plan in Science and Technology for Petroleum and Natural Gas; A participacao do setor produtivo nos projetos financiados pelo CTPETRO - Plano Nacional de Ciencia e Tecnologia de Petroleo e Gas Natural

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Fabiana; Pereira, Newton Mueller [Universidade Estadual de Campinas, SP (Brazil). Inst. de Geociencias. Dept. de Politica Cientifica e Tecnologica]. E-mail: fabiana@ige.unicamp.br; newpe@ige.unicamp.br

    2002-07-01

    This paper emphasizes the participation of the equipment and services suppliers for the petroleum sector in the projects financially supported by CTPETRO (National Brazilian Plan in Science and Technology for Petroleum and Natural Gas), according to the edit 03/2000.

  5. Solar Thermochemical Hydrogen Production Research (STCH)

    Energy Technology Data Exchange (ETDEWEB)

    Perret, Robert [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

    2011-05-01

    Eight cycles in a coordinated set of projects for Solar Thermochemical Cycles for Hydrogen production (STCH) were self-evaluated for the DOE-EERE Fuel Cell Technologies Program at a Working Group Meeting on October 8 and 9, 2008. This document reports the initial selection process for development investment in STCH projects, the evaluation process meant to reduce the number of projects as a means to focus resources on development of a few most-likely-to-succeed efforts, the obstacles encountered in project inventory reduction and the outcomes of the evaluation process. Summary technical status of the projects under evaluation is reported and recommendations identified to improve future project planning and selection activities.

  6. Marketing research: Pathway to optimal market oriented products ...

    African Journals Online (AJOL)

    This paper examines the role of marketing research as pathway to developing optimal market oriented products. The objectives of this paper among others are to (i) Establish whether the use of marketing research has effect on new product adoption process by consumers (ii) Find out if there is any relationship between the ...

  7. Identifying and Researching Market Opportunities for New High Technology Products.

    Science.gov (United States)

    Dunstan, Peter

    Using a product called the synchro-pulse welder as a case study example, this paper discusses the activities of CSIRO (Commonwealth Scientific and Industrial Research Organisation) in identifying and marketing new high-technology products. A general discussion of CSIRO's market research plans includes two goals to be attained within the next 5…

  8. Factors affecting research productivity of production and operations management groups: An empirical study

    OpenAIRE

    George C. Hadjinicola; Andreas C. Soteriou

    2006-01-01

    This paper identifies factors that promote research productivity of production and operations management (POM) groups of researchers in US business schools. In this study, research productivity of a POM group is defined as the number of articles published per POM professor in a specific period of time. The paper also examines factors that affect research quality, as measured by the number of articles published per POM professor in journals, which have been recognized in the POM literature as ...

  9. Peat production. Review of research projects; Turvetuotanto. Tutkimusalueen katsaus

    Energy Technology Data Exchange (ETDEWEB)

    Leinonen, A. [VTT Energy, Jyvaeskylae (Finland)

    1997-12-01

    The development target in the research area of peat production is to improve the competitiveness of peat by reducing production costs by 20 % (by FIM 5 - 6/MWh) from the level of the year 1992 and to reduce environmental impacts. The most important research objects by which the target in peat production technology will be achieved are drawing and preparation technology, drying technology, mechanical technology, method technology, integration of wood harvesting and peat production, and the application of the results of the OPTIMITURVE Research Programme in practice. (orig.)

  10. Dialogues between audience research and production

    DEFF Research Database (Denmark)

    Redvall, Eva Novrup

    2017-01-01

    This article offers a historical analysis of the audience testing of television drama from The Danish Broadcasting Corporation (DR) by the in-house DR Media Research Department from the mid-1990s until 2016. The article investigates how the methods for testing have changed from more traditional...... focus groups and surveys to include biometric methods (e.g. skin conductance) to measure audience arousal. While audience testing is often primarily viewed as a quality measurement tool for executives, the article argues that testing can also be a dialogue-based tool offering creative practitioners...

  11. Spelling the Domain of Sustainable Product Innovation Research

    DEFF Research Database (Denmark)

    Boks, Casper; McAloone, Tim C.

    2009-01-01

    on research methodologies used (case study research, explorative research, descriptive or prescriptive research), case studies analysed, and theories used (such as innovation theory, institutional theory, organisational learning, entrepreneurship, technology management, or design theory). A recent survey......- and user thinking, product stewardship, environmental management of industrial systems, integrated product policies, environmental technology transfer, sustainable consumption and corporate social responsibility. A related question is to determine how scientific research on the PhD level has been......, including learning from historical developments, towards future research strategies and their industrial application....

  12. Faculty Research Productivity and Organizational Structure in Schools of Nursing.

    Science.gov (United States)

    Kohlenberg, Eileen Mieras

    1992-01-01

    A sample of 128 of 221 nursing faculty completed a scholarly productivity index and organizational inventory, which did not yield significant relationships between productivity and organizational structure. Productivity and prepublication research activities varied positively with procedural specifications in a highly bureaucratic organizational…

  13. Production of mycotoxins on artificially and naturally infested building materials

    DEFF Research Database (Denmark)

    Nielsen, Kristian Fog; Gravesen, S.; Nielsen, P.A.

    1999-01-01

    , especially Asp. ustus and Asp. niger produced many unknown secondary metabolites on the building materials. Analyses of wallpaper and glass-fibre wallpaper naturally infested with Asp. versicolor revealed sterigmatocystin and 5-methoxysterigmatocystin. Analyses of naturally infested wallpaper showed that C......In this study, the ability to produce mycotoxins during growth on artificially infested building materials was investigated for Penicillium chrysogenum, Pen. polonicum, Pen. brevicompactum, Chaetomium spp., Aspergillus ustus, Asp. niger, Ulocladium spp., Alternaria spp., and Paecilomyces spp., all...... isolated from water-damaged building materials. Spores from the different isolates of the above mentioned species were inoculated on gypsum board with and without wallpaper and on chipboard with and without wallpaper. Fungal material was scraped off the materials, extracted, and analyzed using high...

  14. Improving Agricultural Productivity with Radiation Processed Natural Polymers

    International Nuclear Information System (INIS)

    Henriques, Sasha

    2013-01-01

    Full text: Through the power of irradiation to break and create chemical bonds, the natural polymer cassava starch is used to make super water absorbents (SWA), 1kg of which can absorb and hold 200 litres of water and release it slowly over time. Placed in the soil near plants’ roots, SWA can be used where there is little rain or frequent drought. After 9 months the crystals, which resemble sugar crystals, completely disintegrate, leaving no residue. (author)

  15. Application of natural and synthetic polymers in a production of paper

    Directory of Open Access Journals (Sweden)

    Jovanović Slobodan

    2007-01-01

    Full Text Available This work gives the review of most frequently used natural and synthetic polymers in production of paper, board and cardboard. Physical and chemical interaction of natural and synthetic polymers with cellulose fibers, and thus the way these polymers influence the improvement of both production process and the paper characteristics, have been presented.

  16. Procurement management in scientific research and production project

    International Nuclear Information System (INIS)

    Wan Yi

    2008-01-01

    To meet the requirement of development trend of scientific research and production, it is necessary to incorporate the modern procurement management theory in the whole procurement process for the items used in scientific research and production.This paper provided some suggestions to improve the procurement management by introducing the experiences in the application of the modern procurement management methods in the procurement of parts production. (author)

  17. Defining "natural product" between public health and business, 17th to 21st centuries.

    Science.gov (United States)

    Stanziani, Alessandro

    2008-07-01

    The historical definition of a natural product stands at the crossroads of business, health, and the symbolic order of things. Until the end of the 19th century, "natural product" was a synonym of perishable. The emergency of organic chemistry made perishability be replaced with "toxicity". Nowadays, genetics is provoking a radical change in the notion and practises of "natural product". However, these concerns are never entirely opposed to "naturality" as a synonym for sacred and symbolic order. Traceability is largely based upon kosher practices and the association between organic and good for health is hardly based upon sound scientific arguments.

  18. The encounter and analysis of naturally occurring radionuclides in gas and oil production and processing

    International Nuclear Information System (INIS)

    Hartog, F.A.; Jonkers, G.; Knaepen, W.A.I.

    1996-01-01

    As a result of oil and gas production, radioactive daughter elements from the uranium and thorium decay series can be mobilized and transported away from the reservoir. Due to changes in flow regime, temperature, pressure or chemical environment NORs (Naturally Occurring Radionuclides) may build up in products, by-products or waste streams from gas and oil production and processing facilities. Products containing NORs are commonly denoted by the acronym NORM (Naturally Occurring Radioactive Materials). Main topics of this paper are: E and P (Exploration and Production) NORM characteristics; incentives for NORM analysis; NORM analysis; interlaboratory test programme; analysis techniques; results and conclusions of the test programme. 4 figs., 2 tabs

  19. Using natural language processing techniques to inform research on nanotechnology

    Directory of Open Access Journals (Sweden)

    Nastassja A. Lewinski

    2015-07-01

    Full Text Available Literature in the field of nanotechnology is exponentially increasing with more and more engineered nanomaterials being created, characterized, and tested for performance and safety. With the deluge of published data, there is a need for natural language processing approaches to semi-automate the cataloguing of engineered nanomaterials and their associated physico-chemical properties, performance, exposure scenarios, and biological effects. In this paper, we review the different informatics methods that have been applied to patent mining, nanomaterial/device characterization, nanomedicine, and environmental risk assessment. Nine natural language processing (NLP-based tools were identified: NanoPort, NanoMapper, TechPerceptor, a Text Mining Framework, a Nanodevice Analyzer, a Clinical Trial Document Classifier, Nanotoxicity Searcher, NanoSifter, and NEIMiner. We conclude with recommendations for sharing NLP-related tools through online repositories to broaden participation in nanoinformatics.

  20. Constraining Methane Emissions from Natural Gas Production in Northeastern Pennsylvania Using Aircraft Observations and Mesoscale Modeling

    Science.gov (United States)

    Barkley, Z.; Davis, K.; Lauvaux, T.; Miles, N.; Richardson, S.; Martins, D. K.; Deng, A.; Cao, Y.; Sweeney, C.; Karion, A.; Smith, M. L.; Kort, E. A.; Schwietzke, S.

    2015-12-01

    Leaks in natural gas infrastructure release methane (CH4), a potent greenhouse gas, into the atmosphere. The estimated fugitive emission rate associated with the production phase varies greatly between studies, hindering our understanding of the natural gas energy efficiency. This study presents a new application of inverse methodology for estimating regional fugitive emission rates from natural gas production. Methane observations across the Marcellus region in northeastern Pennsylvania were obtained during a three week flight campaign in May 2015 performed by a team from the National Oceanic and Atmospheric Administration (NOAA) Global Monitoring Division and the University of Michigan. In addition to these data, CH4 observations were obtained from automobile campaigns during various periods from 2013-2015. An inventory of CH4 emissions was then created for various sources in Pennsylvania, including coalmines, enteric fermentation, industry, waste management, and unconventional and conventional wells. As a first-guess emission rate for natural gas activity, a leakage rate equal to 2% of the natural gas production was emitted at the locations of unconventional wells across PA. These emission rates were coupled to the Weather Research and Forecasting model with the chemistry module (WRF-Chem) and atmospheric CH4 concentration fields at 1km resolution were generated. Projected atmospheric enhancements from WRF-Chem were compared to observations, and the emission rate from unconventional wells was adjusted to minimize errors between observations and simulation. We show that the modeled CH4 plume structures match observed plumes downwind of unconventional wells, providing confidence in the methodology. In all cases, the fugitive emission rate was found to be lower than our first guess. In this initial emission configuration, each well has been assigned the same fugitive emission rate, which can potentially impair our ability to match the observed spatial variability

  1. Marine Natural Product Chemistry and the Interim: A Novel Approach

    Science.gov (United States)

    Bland, Jeffrey S.; Medcalf, Darrell G.

    1974-01-01

    Describes a course designed to strengthen a student's background in organic chemistry, demonstrate the interfacing of chemistry and biology, expose undergraduates to graduate research, provide familiarity with instrumentation, and provide a novel field experience. (Author/GS)

  2. Cytokine and antibody production in naturally occuring caprine ...

    African Journals Online (AJOL)

    http://dx.doi.org/10.4314/tv.v23i1.4567 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER RESOURCES... for Researchers · for Journals · for Authors · for Policy Makers ...

  3. METHANOL PRODUCTION FROM BIOMASS AND NATURAL GAS AS TRANSPORTATION FUEL

    Science.gov (United States)

    Two processes are examined for production of methanol. They are assessed against the essential requirements of a future alternative fuel for road transport: that it (i) is producible in amounts comparable to the 19 EJ of motor fuel annually consumed in the U.S., (ii) minimizes em...

  4. Experience curve for natural gas production by hydraulic fracturing

    NARCIS (Netherlands)

    Fukui, R.; Greenfield, C.; Pogue, K.; van der Zwaan, B.

    From 2007 to 2012 shale gas production in the US expanded at an astounding average growth rate of over 50yr, and thereby increased nearly tenfold over this short time period alone. Hydraulic fracturing technology, or ``fracking'', as well as new directional drilling techniques, played key roles in

  5. Emissions of CH4 from natural gas production in the United States using aircraft-based observations (Invited)

    Science.gov (United States)

    Sweeney, C.; Ryerson, T. B.; Karion, A.; Peischl, J.; Petron, G.; Schnell, R. C.; Tsai, T.; Crosson, E.; Rella, C.; Trainer, M.; Frost, G. J.; Hardesty, R. M.; Montzka, S. A.; Dlugokencky, E. J.; Tans, P. P.

    2013-12-01

    New extraction technologies are making natural gas from shale and tight sand gas reservoirs in the United States (US) more accessible. As a result, the US has become the largest producer of natural gas in the world. This growth in natural gas production may result in increased leakage of methane, a potent greenhouse gas, offsetting the climate benefits of natural gas relative to other fossil fuels. Methane emissions from natural gas production are not well quantified because of the large variety of potential sources, the variability in production and operating practices, the uneven distribution of emitters, and a lack of verification of emission inventories with direct atmospheric measurements. Researchers at the NOAA Earth System Research Laboratory (ESRL) have used simple mass balance approaches to estimate emissions of CH4 from several natural gas and oil plays across the US. We will summarize the results of the available aircraft and ground-based atmospheric emissions estimates to better understand the spatial and temporal distribution of these emissions in the US.

  6. Emissions of CH4 from natural gas production in the United States using aircraft-based observations

    Science.gov (United States)

    Sweeney, Colm; Karion, Anna; Petron, Gabrielle; Ryerson, Thomas; Peischl, Jeff; Trainer, Michael; Rella, Chris; Hardesty, Michael; Crosson, Eric; Montzka, Stephen; Tans, Pieter; Shepson, Paul; Kort, Eric

    2014-05-01

    New extraction technologies are making natural gas from shale and tight sand gas reservoirs in the United States (US) more accessible. As a result, the US has become the largest producer of natural gas in the world. This growth in natural gas production may result in increased leakage of methane, a potent greenhouse gas, offsetting the climate benefits of natural gas relative to other fossil fuels. Methane emissions from natural gas production are not well quantified because of the large variety of potential sources, the variability in production and operating practices, the uneven distribution of emitters, and a lack of verification of emission inventories with direct atmospheric measurements. Researchers at the NOAA Earth System Research Laboratory (ESRL) have used simple mass balance approaches in combination with isotopes and light alkanes to estimate emissions of CH4 from several natural gas and oil plays across the US. We will summarize the results of the available aircraft and ground-based atmospheric emissions estimates to better understand the spatial and temporal distribution of these emissions in the US.

  7. Analysis of Specific Features of the Ukrainian Market of Natural Gas Production and Consumption

    Directory of Open Access Journals (Sweden)

    Lelyuk Oleksiy V.

    2013-11-01

    Full Text Available The article provides results of the study of specific features of the Ukrainian market of natural gas production and consumption. It analyses dynamics of the specific weight of Ukraine in general volumes of natural gas consumption in the world, dynamics of natural gas consumption in Ukraine during 1990 – 2012 and dependence of natural gas consumption on GDP volumes by the purchasing power parity. It studies the structure of natural gas consumption by regions in 2012 and sectors of economy, resource base of natural gas in Ukraine and also dynamics of established resources of natural gas in Ukraine and dynamics of natural gas production. It analyses base rates of growth of natural gas resources and production in Ukraine. It considers dynamics of import of natural gas into Ukraine and its import prices and also the structure of natural gas import. It identifies the balance of the natural gas market in Ukraine. On the basis of the conducted analysis the article proves that Ukraine is a gas-deficit country of the world, which depends on natural gas import supplies.

  8. Production and Evaluation of 236gNp and Reference Materials for Naturally Occurring Radioactive Materials

    Science.gov (United States)

    Larijani, Cyrus Kouroush

    This thesis is based on the development of a radiochemical separation scheme capable of separating both 236gNp and 236Pu from a uranium target of natural isotopic composition ( 1 g uranium) and 200 MBq of fission decay products. The isobaric distribution of fission residues produced following the bombardment of a natural uranium target with a beam of 25 MeV protons has been evaluated. Decay analysis of thirteen isobarically distinct fission residues were carried out using high-resolution gamma-ray spectrometry at the UK National Physical Laboratory. Stoichiometric abundances were calculated via the determination of absolute activity concentrations associated with the longest-lived members of each isobaric chain. This technique was validated by computational modelling of likely sequential decay processes through an isobaric decay chain. The results were largely in agreement with previously published values for neutron bombardments on natural uranium at energies of 14 MeV. Higher relative yields of products with mass numbers A 110-130 were found, consistent with the increasing yield of these radionuclides as the bombarding energy is increased. Using literature values for the production cross-section for fusion of protons with uranium targets, it is estimated that an upper limit of approximately 250 Bq of activity from the 236Np ground state was produced in this experiment. Using a radiochemical separation scheme, Np and Pu fractions were separated from the produced fission decay products, with analyses of the target-based final reaction products made using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and high-resolution alpha and gamma-ray spectrometry. In a separate research theme, reliable measurement of Naturally Occurring Radioactive Materials is of significance in order to comply with environmental regulations and for radiological protection purposes. The thesis describes the standardisation of three reference materials, namely Sand, Tuff and TiO2 which

  9. A roadmap for knowledge exchange and mobilization research in conservation and natural resource management.

    Science.gov (United States)

    Nguyen, Vivian M; Young, Nathan; Cooke, Steven J

    2017-08-01

    Scholars across all disciplines have long been interested in how knowledge moves within and beyond their community of peers. Rapid environmental changes and calls for sustainable management practices mean the best knowledge possible is needed to inform decisions, policies, and practices to protect biodiversity and sustainably manage vulnerable natural resources. Although the conservation literature on knowledge exchange (KE) and knowledge mobilization (KM) has grown in recent years, much of it is based on context-specific case studies. This presents a challenge for learning cumulative lessons from KE and KM research and thus effectively using knowledge in conservation and natural resources management. Although continued research on the gap between knowledge and action is valuable, overarching conceptual frameworks are now needed to enable summaries and comparisons across diverse KE-KM research. We propose a knowledge-action framework that provides a conceptual roadmap for future research and practice in KE/KM with the aim of synthesizing lessons learned from contextual case studies and guiding the development and testing of hypotheses in this domain. Our knowledge-action framework has 3 elements that occur at multiple levels and scales: knowledge production (e.g., academia and government), knowledge mediation (e.g., knowledge networks, actors, relational dimension, and contextual dimension), and knowledge-based action (e.g., instrumental, symbolic, and conceptual). The framework integrates concepts from the sociology of science in particular, and serves as a guide to further comprehensive understanding of knowledge exchange and mobilization in conservation and sustainable natural resource management. © 2016 Society for Conservation Biology.

  10. VAO Tools Enhance CANDELS Research Productivity

    Science.gov (United States)

    Greene, Gretchen; Donley, J.; Rodney, S.; LAZIO, J.; Koekemoer, A. M.; Busko, I.; Hanisch, R. J.; VAO Team; CANDELS Team

    2013-01-01

    The formation of galaxies and their co-evolution with black holes through cosmic time are prominent areas in current extragalactic astronomy. New methods in science research are building upon collaborations between scientists and archive data centers which span large volumes of multi-wavelength and heterogeneous data. A successful example of this form of teamwork is demonstrated by the CANDELS (Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey) and the Virtual Astronomical Observatory (VAO) collaboration. The CANDELS project archive data provider services are registered and discoverable in the VAO through an innovative web based Data Discovery Tool, providing a drill down capability and cross-referencing with other co-spatially located astronomical catalogs, images and spectra. The CANDELS team is working together with the VAO to define new methods for analyzing Spectral Energy Distributions of galaxies containing active galactic nuclei, and helping to evolve advanced catalog matching methods for exploring images of variable depths, wavelengths and resolution. Through the publication of VOEvents, the CANDELS project is publishing data streams for newly discovered supernovae that are bright enough to be followed from the ground.

  11. New Product Development and Business Strategy of Research and Development

    International Nuclear Information System (INIS)

    Lee, Sun Cheol

    1998-05-01

    The contents of this book are new product development strategy of the top business, commercialization and new product development, development case analysis and framework of new product development, investigation strategy for idea of new product development, case analysis of research as development and goal of new product development, case analysis and planning and management for new product development, innovative item development and technical management against confusion, the map for determination procedure of development, strategy of market and goods and development strategy cases in leading company.

  12. Purity-activity relationships of natural products: the case of anti-TB active ursolic acid.

    Science.gov (United States)

    Jaki, Birgit U; Franzblau, Scott G; Chadwick, Lucas R; Lankin, David C; Zhang, Fangqiu; Wang, Yuehong; Pauli, Guido F

    2008-10-01

    The present study explores the variability of biological responses from the perspective of sample purity and introduces the concept of purity-activity relationships (PARs) in natural product research. The abundant plant triterpene ursolic acid (1) was selected as an exemplary natural product due to the overwhelming number yet inconsistent nature of its approximate 120 reported biological activities, which include anti-TB potential. Nine different samples of ursolic acid with purity certifications were obtained, and their purity was independently assessed by means of quantitative 1H NMR (qHNMR). Biological evaluation consisted of determining MICs against two strains of virulent Mycobacterium tuberculosis and IC50 values in Vero cells. Ab initio structure elucidation provided unequivocal structural confirmation and included an extensive 1H NMR spin system analysis, determination of nearly all J couplings and the complete NOE pattern, and led to the revision of earlier reports. As a net result, a sigmoid PAR profile of 1 was obtained, demonstrating the inverse correlation of purity and anti-TB bioactivity. The results imply that synergistic effects of 1 and its varying impurities are the likely cause of previously reported antimycobacterial potential. Generating PARs is a powerful extension of the routinely performed quantitative correlation of structure and activity ([Q]SAR). Advanced by the use of primary analytical methods such as qHNMR, PARs enable the elucidation of cases like 1 when increasing purity voids biological activity. This underlines the potential of PARs as a tool in drug discovery and synergy research and accentuates the need to routinely combine biological testing with purity assessment.

  13. The Journal of Stored-Products Research: The living history of stored product protection

    Science.gov (United States)

    This year, the Journal of Stored Products Research (JSPR) completes 52 years of history with publications of research papers. With approx. one hundred articles annually, the JSPR is an important scientific forum for stored product researchers throughout the globe. The aims and scope of JSPR are focu...

  14. Exploring the production of natural gas through the lenses of the ACEGES model

    International Nuclear Information System (INIS)

    Voudouris, Vlasios; Matsumoto, Ken'ichi; Sedgwick, John; Rigby, Robert; Stasinopoulos, Dimitrios; Jefferson, Michael

    2014-01-01

    Due to the increasing importance of natural gas for modern economic activity, and gas's non-renewable nature, it is extremely important to try to estimate possible trajectories of future natural gas production while considering uncertainties in resource estimates, demand growth, production growth and other factors that might limit production. In this study, we develop future scenarios for natural gas supply using the ACEGES computational laboratory. Conditionally on the currently estimated ultimate recoverable resources, the ‘Collective View’ and ‘Golden Age’ Scenarios suggest that the supply of natural gas is likely to meet the increasing demand for natural gas until at least 2035. The ‘Golden Age’ Scenario suggests significant ‘jumps’ of natural gas production – important for testing the resilience of long-term strategies. - Highlights: • We present the ‘Collective View’ and ‘Golden Age’ Scenarios for natural gas production. • We do not observe any significant supply demand pressure of natural gas until 2035. • We do observe ‘jumps’ in natural gas supply until 2035. • The ACEGES-based scenarios can assess the resilience of longterm strategies

  15. Antiviral Activity of Natural Products Extracted from Marine Organisms

    Directory of Open Access Journals (Sweden)

    Sobia Tabassum

    2011-11-01

    Full Text Available Many epidemics have broken out over the centuries. Hundreds and thousands of humans have died over a disease. Available treatments for infectious diseases have always been limited. Some infections are more deadly than the others, especially viral pathogens. These pathogens have continuously resisted all kinds of medical treatment, due to a need for new treatments to be developed. Drugs are present in nature and are also synthesized in vitro and they help in combating diseases and restoring health. Synthesizing drugs is a hard and time consuming task, which requires a lot of man power and financial aid. However, the natural compounds are just lying around on the earth, may it be land or water. Over a thousand novel compounds isolated from marine organisms are used as antiviral agents. Others are being pharmacologically tested. Today, over forty antiviral compounds are present in the pharmacological market. Some of these compounds are undergoing clinical and pre-clinical stages. Marine compounds are paving the way for a new trend in modern medicine.

  16. Research in Knowledge Representation for Natural Language Understanding

    Science.gov (United States)

    1981-11-01

    interpretation would not be too bad if one were to believe that a frame "is intended to represent a ’ stereotypical situation’" ( [24], p. 48). We...natural kind-like concepts - some form of definitional structuring is necessary. The internal structure of non atomic concepts (e.g., proximate genus ...types of beer, bottles of wine, etc.; <x> need not be any sort of Onatural genus .’ For example, in Dll the definite pronoun Othem" is not meant to I

  17. Exposure-dose research for radionuclides in natural gas

    International Nuclear Information System (INIS)

    McNelis, D.N.; Patzer, R.G.

    1969-01-01

    The fate determination of specific radionuclides in natural gas stimulated by underground engineering applications is being examined. An experimental program, now in its initial stages, is using gas artificially labeled with krypton-85 and tritium under simulated domestic situations. The following topics are being investigated in this study: 1. The concentration of the radionuclides in a gas-heated home. 2. The build-up of contamination on appliances in the kitchen environment. 3. The concentration in foods as a function of radionuclide, food type and preparation. 4. The maximum exposure plausible under specified conditions. (author)

  18. Exposure-dose research for radionuclides in natural gas

    Energy Technology Data Exchange (ETDEWEB)

    McNelis, D N; Patzer, R G [Southwestern Radiological Health Laboratory, U.S. Public Health Service, Las Vegas, NV (United States)

    1969-07-01

    The fate determination of specific radionuclides in natural gas stimulated by underground engineering applications is being examined. An experimental program, now in its initial stages, is using gas artificially labeled with krypton-85 and tritium under simulated domestic situations. The following topics are being investigated in this study: 1. The concentration of the radionuclides in a gas-heated home. 2. The build-up of contamination on appliances in the kitchen environment. 3. The concentration in foods as a function of radionuclide, food type and preparation. 4. The maximum exposure plausible under specified conditions. (author)

  19. Market research companies and new product development tools

    NARCIS (Netherlands)

    Nijssen, E.J.; Frambach, R.T.

    1998-01-01

    This research investigates (1) the share of new product development (NPD) research services in market research (MR) companies’ turnover, (2) MR companies’ awareness and use of NPD tools and the modifications made to these NPD tools, and (3) MR company managers’ perceptions of the influence of client

  20. Market research companies and new product development tools

    NARCIS (Netherlands)

    Nijssen, Edwin J.; Frambach, Ruud T.

    1998-01-01

    This research investigates (1) the share of new product development (NPD) research services in market research (MR) companies' turnover, (2) MR companies' awareness and use of NPD tools and the modifications made to these NPD tools, and (3) MR company managers' perceptions of the influence of client

  1. The utility of N-15 nuclear magnetic resonance spectroscopy for the study of natural products

    International Nuclear Information System (INIS)

    Randall, E.W.

    1978-01-01

    The utility of 15 N NMR spectroscopy for the study of natural products and the difficulties which must be overcome arte discussed. The widespread use of pulse Fourier techniques, decouplings, larger magnetic fields and large tube sizes allows a large number of 15 N studies of natural products, the more recent and important of these being peptides, nucleosides and nucleotides. Sites of protonation, tautomerism, sites of nitrosation and proton exchange behaviour for some of these natrual products have been studied. (A.G.)

  2. Natural Product-Derived Treatments for Attention-Deficit/Hyperactivity Disorder: Safety, Efficacy, and Therapeutic Potential of Combination Therapy

    Science.gov (United States)

    Ahn, James; Ahn, Hyung Seok; Cheong, Jae Hoon; dela Peña, Ike

    2016-01-01

    Typical treatment plans for attention-deficit/hyperactivity disorder (ADHD) utilize nonpharmacological (behavioral/psychosocial) and/or pharmacological interventions. Limited accessibility to behavioral therapies and concerns over adverse effects of pharmacological treatments prompted research for alternative ADHD therapies such as natural product-derived treatments and nutritional supplements. In this study, we reviewed the herbal preparations and nutritional supplements evaluated in clinical studies as potential ADHD treatments and discussed their performance with regard to safety and efficacy in clinical trials. We also discussed some evidence suggesting that adjunct treatment of these agents (with another botanical agent or pharmacological ADHD treatments) may be a promising approach to treat ADHD. The analysis indicated mixed findings with regard to efficacy of natural product-derived ADHD interventions. Nevertheless, these treatments were considered as a “safer” approach than conventional ADHD medications. More comprehensive and appropriately controlled clinical studies are required to fully ascertain efficacy and safety of natural product-derived ADHD treatments. Studies that replicate encouraging findings on the efficacy of combining botanical agents and nutritional supplements with other natural product-derived therapies and widely used ADHD medications are also warranted. In conclusion, the risk-benefit balance of natural product-derived ADHD treatments should be carefully monitored when used as standalone treatment or when combined with other conventional ADHD treatments. PMID:26966583

  3. Research on Paramecium aurelia sensitivity factors to natural ionizing radiations

    International Nuclear Information System (INIS)

    Croute, F.; Soleilhavoup, J.P.; Gros, N.; Planel, H.

    1976-01-01

    Previous results have demonstrated that the proliferative activity of Paramecium aurelia is linked to the level of natural ionizing radiations since this activity is decreased under radiation protection (lead cell) and increased under chronic exposure to very low dose of 60 Co gamma rays. The results of this investigation indicate that cell sensitivity in spite of variations in natural irradiation levels can be isolated; they are called 'radioresistant' in opposition to 'radiosensitive' cells which present the other response. These characters are being retained for 9 months after the strains have been isolated. On the other hand, in the case of radiosensitive strains, it has been demonstrated that autogamy affected the cell response to background irradiation; no response at all occured on the very day when autogamy took place, but it reached a maximum level 8 days approximately after autogamy. Moreover, it has been proved that the catalase activity of Paramecium aurelia is higher than those already studied in other cell varieties. This great amount of catalase, which seems to vary with the age of cultures after autogamy, could act on Paramecium sensitivity to very low radiation doses [fr

  4. The Productivity and Natural Increase of Swamp Buffalo in District Malang

    Science.gov (United States)

    Budiarto, A.; Ciptadi, G.

    2018-02-01

    The purpose of this research was to collect the basic information needed to develop a sustainable breeding program, which includes the potential for production and reproduction of buffaloes. This research was conducted on swamp buffalo in Malang Regency East Java. The research method used was survey method. Primary data was obtained from direct observation on 323 tails owned by 98 breeders. Variables observed were population growth and reproductive performance. The data obtained were analyzed descriptively. The result showed that the initial population study of swamp Buffaloes in Malang as many as 1155 with male and female ratio 1: 2. The ratios of male and female swamp Buffalo 20 percent male and 80 percent female. Overall, the buffalo reproduction performance was still low. Service per conception 2.06 ± 0.88; Anestrus Postpartum 7.46 ± 3.83 months; calving interval distance 17.82 ± 4.86 months; 20.43 % birth rate and 4.33% mortality rate of Natural Increase (NI) population was about 16,1%. In conclusion, the value of NI of swamp Buffalo in Malang Regency is still low. To increase buffalo productivity, buffalo breeding program is continuously based on reproduction control.

  5. Considerations for higher efficiency and productivity in research activities.

    Science.gov (United States)

    Forero, Diego A; Moore, Jason H

    2016-01-01

    There are several factors that are known to affect research productivity; some of them imply the need for large financial investments and others are related to work styles. There are some articles that provide suggestions for early career scientists (PhD students and postdocs) but few publications are oriented to professors about scientific leadership. As academic mentoring might be useful at all levels of experience, in this note we suggest several key considerations for higher efficiency and productivity in academic and research activities. More research is needed into the main work style features that differentiate highly productive scientists and research groups, as some of them could be innate and others could be transferable. As funding agencies, universities and research centers invest large amounts of money in order to have a better scientific productivity, a deeper understanding of these factors will be of high academic and societal impact.

  6. Five decades in the study of natural products*

    Indian Academy of Sciences (India)

    Unknown

    Medical College to work for the M Sc degree by research under Prof B B Dey at. Presidency College .... small group of us worked on plant chemistry. We had plant .... Enough funds were provided for equipment so that we could undertake good ...

  7. ​Affordable natural product reduces fruit losses, increases incomes ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Advancing science, enhancing fruit life The project uses cutting-edge science to extend and optimize the use of hexanal for pre- and post-harvest applications to ... The Tamil Nadu Agricultural University in India, the Industrial Technology Institute in Sri Lanka, and the University of Guelph in Canada will work with research ...

  8. Nigerian Journal of Natural Products and Medicine: Advanced Search

    African Journals Online (AJOL)

    Search tips: Search terms are case-insensitive; Common words are ignored; By default only articles containing all terms in the query are returned (i.e., AND is implied); Combine multiple words with OR to find articles containing either term; e.g., education OR research; Use parentheses to create more complex queries; e.g., ...

  9. The Vatican museum and the organic natural products. The Raphael's frescoes and the "Last Judgment" by Nicolò and Giovanni.

    Science.gov (United States)

    Gabrielli, Nazzareno; Guiso, Marcella; Bianco, Armandodoriano

    2017-05-25

    In the second half of the 90s, alongside the restoration works of the Quattrocentisti (fifteenth century painters) in the Sistine Chapel, it also carried out the restoration of the frescoes of the Stanze di Raffaello. The results of scientific investigations conducted by the Scientific Research Laboratory of the Vatican Museums, previously presented in some assays of study, are summarised and presented in this letter to the Editor for the special issue of Natural Product Research: Natural Products in Cultural Heritage.

  10. Radioisotope production experience at the Cintichem 5-MW research reactor

    International Nuclear Information System (INIS)

    McGovern, J.J.

    1993-01-01

    The Cintichem radiochemical production facility was constructed in the late 1950s and became operational in October of 1961. The facility was originally designed and constructed by Union Carbide Corporation for research and development of nuclear technology with the ultimate objective of exploiting it commercially. Research projects were conducted in the fields of direct energy conversion for the production of electric power and chemical synthesis, neutron spectrometry, nuclear fuel cycle development, and radiochemical production. Radiochemical production for medical applications was the only development project that was successfully commercialized

  11. Foreign direct investment in South Africa: how big is Southern Africa’s natural product opportunity and what trade issues impede sectoral development?

    OpenAIRE

    Bennett, Ben

    2006-01-01

    This study was conducted to identify the scale of the trade opportunity for natural product exports from Southern Africa and to recommend actions to address market access issues constraining sectoral growth.\\ud Field research was undertaken in Malawi, Zimbabwe, Namibia, South Africa and the United Kingdom between 9th January and 25th February 2006. The study concentrated on ten countries in Southern Africa1 with potential to export significant quantities of natural products. These products ar...

  12. Patented installations for the production of methane and natural manures

    Energy Technology Data Exchange (ETDEWEB)

    Milquet, F

    1951-12-01

    Current processes are reviewed and a new technique is described which maintains economically a constant temperature of 40/sup 0/C in the tanks by complete isolation in winter as in summer and periodic reheating of the mass. The tanks were buried underground and had double metal walls with low density cellular concrete between them. The covers were of thick cork, permanently fixed, and coated with an impermeable substance. Reheating was necessary only once during the fermentation, whereas with tanks above ground it had to be carried out more often and more vigorously. Straw was the raw material and the products were highly profitable quantities of methane and artificial manure.

  13. Information Science Research: The Search for the Nature of Information.

    Science.gov (United States)

    Kochen, Manfred

    1984-01-01

    High-level scientific research in the information sciences is illustrated by sampling of recent discoveries involving adaptive information processing strategies, computer and information systems, centroid scaling, economic growth of computer and communication industries, and information flow in biological systems. Relationship of information…

  14. Course Level and the Relationship between Research Productivity and Teaching Effectiveness

    Science.gov (United States)

    Arnold, Ivo J. M.

    2008-01-01

    The author examines the relationship between research productivity and teaching effectiveness using data from the Erasmus School of Economics. The initial findings indicate a positive overall relationship between the variables. A more detailed analysis reveals a sharp reversal in the nature of the relationship. Although the relationship is…

  15. Cracking the regulatory code of biosynthetic gene clusters as a strategy for natural product discovery.

    Science.gov (United States)

    Rigali, Sébastien; Anderssen, Sinaeda; Naômé, Aymeric; van Wezel, Gilles P

    2018-01-05

    The World Health Organization (WHO) describes antibiotic resistance as "one of the biggest threats to global health, food security, and development today", as the number of multi- and pan-resistant bacteria is rising dangerously. Acquired resistance phenomena also impair antifungals, antivirals, anti-cancer drug therapy, while herbicide resistance in weeds threatens the crop industry. On the positive side, it is likely that the chemical space of natural products goes far beyond what has currently been discovered. This idea is fueled by genome sequencing of microorganisms which unveiled numerous so-called cryptic biosynthetic gene clusters (BGCs), many of which are transcriptionally silent under laboratory culture conditions, and by the fact that most bacteria cannot yet be cultivated in the laboratory. However, brute force antibiotic discovery does not yield the same results as it did in the past, and researchers have had to develop creative strategies in order to unravel the hidden potential of microorganisms such as Streptomyces and other antibiotic-producing microorganisms. Identifying the cis elements and their corresponding transcription factors(s) involved in the control of BGCs through bioinformatic approaches is a promising strategy. Theoretically, we are a few 'clicks' away from unveiling the culturing conditions or genetic changes needed to activate the production of cryptic metabolites or increase the production yield of known compounds to make them economically viable. In this opinion article, we describe and illustrate the idea beyond 'cracking' the regulatory code for natural product discovery, by presenting a series of proofs of concept, and discuss what still should be achieved to increase the rate of success of this strategy. Copyright © 2018 Elsevier Inc. All rights reserved.

  16. Analogical reasoning and the nature of context: a research note.

    Science.gov (United States)

    Richardson, K; Webster, D S

    1996-03-01

    Recent theorising about children's reasoning has tended to move towards a 'contextualist' view of cognition and away from the idea of an overall, context-free, mechanism, varying in efficiency, which is the presupposition underlying traditional standardised reasoning tests. An earlier study suggesting improved reasoning performance among children on socio-cognitively meaningful versions of Raven's Matrices tended to support this shift. The main purpose of the study reported here was to observe whether a similar improvement would be found with contextually-based analogical reasoning problems as well. Ten analogy items from a standardised test were administered to 11-year-olds together with 10 structurally-equivalent knowledge-based items. The results reflected improved performance on the latter, overall, and additional analyses led to further suggestions about the nature of the 'contextual advantage' and the origins of item difficulty.

  17. Catalyst-controlled oligomerization for the collective synthesis of polypyrroloindoline natural products.

    Science.gov (United States)

    Jamison, Christopher R; Badillo, Joseph J; Lipshultz, Jeffrey M; Comito, Robert J; MacMillan, David W C

    2017-12-01

    In nature, many organisms generate large families of natural product metabolites that have related molecular structures as a means to increase functional diversity and gain an evolutionary advantage against competing systems within the same environment. One pathway commonly employed by living systems to generate these large classes of structurally related families is oligomerization, wherein a series of enzymatically catalysed reactions is employed to generate secondary metabolites by iteratively appending monomers to a growing serial oligomer chain. The polypyrroloindolines are an interesting class of oligomeric natural products that consist of multiple cyclotryptamine subunits. Herein we describe an iterative application of asymmetric copper catalysis towards the synthesis of six distinct oligomeric polypyrroloindoline natural products: hodgkinsine, hodgkinsine B, idiospermuline, quadrigemine H and isopsychotridine B and C. Given the customizable nature of the small-molecule catalysts employed, we demonstrate that this strategy is further amenable to the construction of quadrigemine H-type alkaloids not isolated previously from natural sources.

  18. Insects: an underrepresented resource for the discovery of biologically active natural products

    Directory of Open Access Journals (Sweden)

    Lauren Seabrooks

    2017-07-01

    Full Text Available Nature has been the source of life-changing and -saving medications for centuries. Aspirin, penicillin and morphine are prime examples of Nature׳s gifts to medicine. These discoveries catalyzed the field of natural product drug discovery which has mostly focused on plants. However, insects have more than twice the number of species and entomotherapy has been in practice for as long as and often in conjunction with medicinal plants and is an important alternative to modern medicine in many parts of the world. Herein, an overview of current traditional medicinal applications of insects and characterization of isolated biologically active molecules starting from approximately 2010 is presented. Insect natural products reviewed were isolated from ants, bees, wasps, beetles, cockroaches, termites, flies, true bugs, moths and more. Biological activities of these natural products from insects include antimicrobial, antifungal, antiviral, anticancer, antioxidant, anti-inflammatory and immunomodulatory effects.

  19. [Elaboration of Pseudo-natural Products Using Artificial In Vitro Biosynthesis Systems].

    Science.gov (United States)

    Goto, Yuki

    2018-01-01

     Peptidic natural products often consist of not only proteinogenic building blocks but also unique non-proteinogenic structures such as macrocyclic scaffolds and N-methylated backbones. Since such non-proteinogenic structures are important structural motifs that contribute to diverse bioactivity, we have proposed that peptides with non-proteinogenic structures should be attractive candidates as artificial bioactive peptides mimicking natural products, or so-called pseudo-natural products. We previously devised an engineered translation system for pseudo-natural peptides, referred to as the flexible in vitro translation (FIT) system. This system enabled "one-pot" synthesis of highly diverse pseudo-natural peptide libraries, which can be rapidly screened by mRNA display technology for the discovery of pseudo-natural peptides with diverse bioactivities.

  20. Remodeling the blood–brain barrier microenvironment by natural products for brain tumor therapy

    Institute of Scientific and Technical Information of China (English)

    Xiao Zhao; Rujing Chen; Mei Liu; Jianfang Feng; Jun Chen; Kaili Hu

    2017-01-01

    Brain tumor incidence shows an upward trend in recent years; brain tumors account for 5% of adult tumors, while in children, this figure has increased to 70%. Moreover, 20%–30% of malignant tumors will eventually metastasize into the brain. Both benign and malignant tumors can cause an increase in intracranial pressure and brain tissue compression, leading to central nervous system(CNS) damage which endangers the patients’ lives. Despite the many approaches to treating brain tumors and the progress that has been made, only modest gains in survival time of brain tumor patients have been achieved. At present, chemotherapy is the treatment of choice for many cancers, but the special structure of the blood–brain barrier(BBB) limits most chemotherapeutic agents from passing through the BBB and penetrating into tumors in the brain. The BBB microenvironment contains numerous cell types, including endothelial cells, astrocytes, peripheral cells and microglia, and extracellular matrix(ECM). Many chemical components of natural products are reported to regulate the BBB microenvironment near brain tumors and assist in their treatment. This review focuses on the composition and function of the BBB microenvironment under both physiological and pathological conditions, and the current research progress in regulating the BBB microenvironment by natural products to promote the treatment of brain tumors.

  1. Boosting the bioavailability of hydrophobic nutrients, vitamins, and nutraceuticals in natural products using excipient emulsions.

    Science.gov (United States)

    McClements, David Julian; Saliva-Trujillo, Laura; Zhang, Ruojie; Zhang, Zipei; Zou, Liqiang; Yao, Mingfei; Xiao, Hang

    2016-10-01

    Many highly hydrophobic bioactives, such as non-polar nutrients, nutraceuticals, and vitamins, have a relatively low or variable oral bioavailability. The poor bioavailability profile of these bioactives may be due to limited bioaccessibility, poor absorption, and/or chemical transformation within the gastrointestinal tract (GIT). The bioavailability of hydrophobic bioactives can be improved using specially designed oil-in-water emulsions consisting of lipid droplets dispersed within an aqueous phase. The bioactives may be isolated from their natural environment and then incorporated into the lipid phase of emulsion-based delivery systems. Alternatively, the bioactives may be left in their natural environment (e.g., fruits or vegetables), and then ingested with emulsion-based excipient systems. An excipient emulsion may have no inherent health benefits itself, but it boosts the biological activity of bioactive ingredients co-ingested with it by altering their bioaccessibility, absorption, and/or chemical transformation. This review discusses the design and fabrication of excipient emulsions, and gives some examples of recent research that demonstrates their potential efficacy for improving the bioavailability of hydrophobic bioactives. The concept of excipient emulsions could be used to formulate emulsion-based food products (such as excipient sauces, dressings, dips, creams, or yogurts) specifically designed to increase the bioavailability of bioactive agents in natural foods, such as fruits and vegetables. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Natural products inhibitors of the angiotensin converting enzyme (ACE: a review between 1980 - 2000

    Directory of Open Access Journals (Sweden)

    José M. Barbosa-Filho

    Full Text Available Inhibition of Angiotensin Converting Enzyme (ACE is a modern therapeutic target in the treatment of hypertension. Within the enzyme cascade of the renin-angiotensin system, ACE removes histidyl-leucine from angiotensin I to form the physiologically active octapeptide angiotensin II, one of the most potent known vasoconstrictors. Therefore, a rationale for treating hypertension would be to administer drugs or natural compounds which selectively inhibit ACE. The present work constitutes a review of the literature of plants and chemically defined molecules from natural sources with in vitro anti-hypertensive potential based on the inhibition of ACE. The review refers to 321 plants, the parts utilized, type of extract and whether they are active or not. It includes also the names of 158 compounds isolated from higher plants, marine sponges and algae, fungi and snake venom. Some aspects of recent research with natural products directed to produce anti-hypertensive drugs are discussed. In this review, 148 references were cited.

  3. THE EFFECT OF AMOUNT OF NATURAL ZEOLIT CATALYST IN PRODUCT OF POLYPROPILENE (PP PLASTIC WASTE PYROLYSIS

    Directory of Open Access Journals (Sweden)

    khalimatus sa'diyah

    2015-12-01

    Full Text Available To overcome the waste problem, especially plastic waste , environmental concerned scientists from various disciplines have conducted various research and actions. Catalytic pyrolysis processes was chosen as an alternative method to recycle plastic waste. The purpose of this experiment was to determine the effect of natural zeolit catalyst on the pyrolysis process with oxygen-free conditions to obtain maximum hydrocarbon compounds (gasoline fraction in C5-C9. The process of pyrolysis was conducted in 3.5 dm3 unstirred stainless steel semi-batch reactor. This process operated at atmospheric pressure with nitrogen injection. Plastic waste that used in this particular paper was 50 grams of polypropylene (PP. In pyrolysis process, natural zeolite catalysts was added 2,5 gram (5% weight of natural zeolite per weight of plastic waste samples, 5 gram (10% , and 10 gram (20%. Temperature of pyrolysis was 450°C and were maintained until 30 minutes. Steam that produced from pyrolisis was condensed and analysed by gas chromatography–mass spectrometry (GC-MS to determine yield of hydrocarbons produced. From the analysis of GC-MS, liquid products of pyrolysis contained lots of aromatic hydrocarbons. The optimal amount of catalyst that produce liquid with hydrocarbon compound that has the quality of gasoline was 10 gram (20% with ≤C9 composition as 29,16% n-paraffin, 9,22% cycloparaffin, and 61,64% aromatics.

  4. Sustainability, natural and organic cosmetics: consumer, products, efficacy, toxicological and regulatory considerations

    Directory of Open Access Journals (Sweden)

    Bruno Fonseca-Santos

    2015-03-01

    Full Text Available The interest in sustainable products has increased along the years, since the choice of products, packaging and production processes have a great impact on the environment. These products are classified by regulatory agencies in different categories, aggregating advantages to the product and increasing the demand by consumers. However, there is no harmonization in guidelines of these certifying agencies and each cosmetic industry formulates their product and packaging in a more rational way, which causes less damage to the environment. Many cosmetic products have in their formulation natural products that perform a specific biological function, but these products should be evaluated on efficacy and toxicological aspects. The aim of this article is to approach sustainability, natural and organic cosmetics, considering the consumer and the efficacy, toxicological and regulatory aspects.

  5. Development of Reservoir Characterization Techniques and Production Models for Exploiting Naturally Fractured Reservoirs

    Energy Technology Data Exchange (ETDEWEB)

    Wiggins, Michael L.; Brown, Raymon L.; Civan, Frauk; Hughes, Richard G.

    2001-08-15

    Research continues on characterizing and modeling the behavior of naturally fractured reservoir systems. Work has progressed on developing techniques for estimating fracture properties from seismic and well log data, developing naturally fractured wellbore models, and developing a model to characterize the transfer of fluid from the matrix to the fracture system for use in the naturally fractured reservoir simulator.

  6. Bioenergy Research Programme. Yearbook 1994. Production of wood fuels

    International Nuclear Information System (INIS)

    Alakangas, E.

    1995-01-01

    BIOENERGIA Research Programme is one of energy technology programmes of the Finnish Ministry of Trade and Industry (in 1995 TEKES, Technology Development Center). The aim of Bioenergy Research Programme is to increase the use of economically profitable and environmentally sound bioenergy by improving the competitiveness of present peat and wood fuels. Research and development projects will also develop new economically competitive biofuels and new equipment and methods for production, handling and using of biofuels. The funding for 1994 was nearly 50 million FIM and projects numbered 60. The main goal of the production of wood fuels research area is to develop new production methods in order to decrease the production costs to the level of imported fuels. The total potential of the wood fuel use should be at least 1.0 million toe/a (5.5 million m 3 ). There were 27 projects in 1994 for research on wood fuel production. This part of the yearbook 1994 presents the main results of these projects. The wood reserves do not limit the obtainability of the target. Research and development work has, however, directed to development of equipment and research on wood fuels production chains. Many devices, designed for both separate and integrated production of wood fuels became ready or were becoming ready for prototyping, to be used for production tests. Results of the biomass harvesting and properties research were obtained for utilization in 1994. According to the results it is possible to obtain the desired targets both in integrated and separated production of wood fuels. (author)

  7. Management of natural health products in pediatrics: a provider-focused quality improvement project.

    Science.gov (United States)

    Gutierrez, Emily; Silbert-Flagg, JoAnne; Vohra, Sunita

    2015-01-01

    The use of natural health products by pediatric patients is common, yet health care providers often do not provide management guidance. The purpose of this project was to improve management of natural health products by pediatric nurse practitioners. Pediatric nurse practitioners from large metropolitan city were recruited (n = 32). A paired pretest-posttest design was used. Study participants were engaged to improve knowledge of natural health products, and a management toolkit was created and tested. Mean knowledge scores increased from 59.19 to 76.3 (p improved with regard to patient guidance (p product use (p = .51) and drug/herb interactions (p = .35) were not significant. This investigation is the first known study to improve knowledge and management of natural health products in pediatric clinical practice. Copyright © 2015 National Association of Pediatric Nurse Practitioners. Published by Elsevier Inc. All rights reserved.

  8. European energy security: An analysis of future Russian natural gas production and exports

    Energy Technology Data Exchange (ETDEWEB)

    Soederbergh, Bengt, E-mail: bengt.soderbergh@fysast.uu.s [Global Energy Systems, Department of Physics and Astronomy, Uppsala University, Laegerhyddsvaegen 1, Box 535, SE-751 21, Uppsala (Sweden); Jakobsson, Kristofer; Aleklett, Kjell [Global Energy Systems, Department of Physics and Astronomy, Uppsala University, Laegerhyddsvaegen 1, Box 535, SE-751 21, Uppsala (Sweden)

    2010-12-15

    The widening gap between EU gas production and consumption may require an 87% increase of import volumes between 2006 and 2030, and there are great uncertainties regarding the amounts of gas that can be expected from new suppliers. The potential of increased production from Norway and Algeria is limited; hence, Russia is likely to play a crucial part of meeting the anticipated growing gas demand of the EU. A field-by-field study of 83 giant gas fields shows that the major producing Russian gas fields are in decline, and by 2013 much larger supplies from the Yamal Peninsula and the Shtokman field will be needed in order to avoid a decline in production. Gas from fields in Eastern Siberia and the Far East will mainly be directed to the Asian and Pacific Rim markets, thereby limiting its relevance to the European and CIS markets. As a result, the maximum export increase to the European and CIS markets amounts only to about 45% for the period 2015-2030. The discourse surrounding the EU's dependence on Russian gas should thus not only be concerned with geopolitics, but also with the issue of resource limitations. - Research highlights: {yields}Natural gas production in the Nadym Pur Taz region (Western Siberia) will start to decline within a few years. {yields}New production from the Yamal peninsula is critical to ensure gas exports to Europe. {yields}Additional production in East Siberia and the Far East will not be available for the European market. {yields}Rapid gas demand growth in China might also lead to competition for gas from Western Siberia.

  9. Research in biomass production and utilization: Systems simulation and analysis

    Science.gov (United States)

    Bennett, Albert Stewart

    of a mobile juice harvester is not economically viable due to low sugar recovery. The addition of front-end stalk processing/pressing equipment into existing ethanol facilities was found to be economically viable when combined with the plants' use of residuals as a natural gas fuel replacement. Because of high loss of fermentable carbohydrates during ensilage, storage of sweet sorghum in bunkers was not found to be economically viable. The fourth section looks at double cropping winter triticale with late-planted summer corn and compares these scenarios to traditional single cropped corn. Double cropping systems show particular promise for co-production of grain and biomass feedstocks and potentially can allow for greater utilization of grain crop residues. However, additional costs and risks associated with producing two crops instead of one could make biomass-double crops less attractive for producers despite productivity advantages. Detailed evaluation and comparisons show double cropped triticale-corn to be at a significant economic disadvantage relative to single crop corn. The cost benefits associated with using less equipment combined with availability of risk mitigating crop insurance and government subsidies will likely limit farmer interest and clearly indicate that traditional single-crop corn will provide greater financial returns to management. To evaluate the various sweet sorghum, single crop corn and double cropped triticale-corn production scenarios, a detailed but generic model was developed. The primary goal of this generic approach was to develop a modeling foundation that can be rapidly adapted, by an experienced user, to describe new and existing biomass and crop production scenarios that may be of interest to researchers. The foundation model allows input of management practices, crop production characteristics and utilizes standardized machinery performance and cost information, including farm-owned machinery and implements, and machinery and

  10. Transporter-mediated natural product-drug interactions for the treatment of cardiovascular diseases.

    Science.gov (United States)

    Zha, Weibin

    2018-04-01

    The growing use of natural products in cardiovascular (CV) patients has been greatly raising the concerns about potential natural product-CV drug interactions. Some of these may lead to unexpected cardiovascular adverse effects and it is, therefore, essential to identify or predict potential natural product-CV drug interactions, and to understand the underlying mechanisms. Drug transporters are important determinants for the pharmacokinetics of drugs and alterations of drug transport has been recognized as one of the major causes of natural product-drug interactions. In last two decades, many CV drugs (e.g., angiotensin II receptor blockers, beta-blockers and statins) have been identified to be substrates and inhibitors of the solute carrier (SLC) transporters and the ATP-binding cassette (ABC) transporters, which are two major transporter superfamilies. Meanwhile, in vitro and in vivo studies indicate that a growing number of natural products showed cardioprotective effects (e.g., gingko biloba, danshen and their active ingredients) are also substrates and inhibitors of drug transporters. Thus, to understand transporter-mediated natural product-CV drug interactions is important and some transporter-mediated interactions have already shown to have clinical relevance. In this review, we review the current knowledge on the role of ABC and SLC transporters in CV therapy, as well as transporter modulation by natural products used in CV diseases and their induced natural product-CV drug interactions through alterations of drug transport. We hope our review will aid in a comprehensive summary of transporter-mediated natural product-CV drug interactions and help public and physicians understand these type of interactions. Copyright © 2017. Published by Elsevier B.V.

  11. Natural Products for the Treatment of Trachoma and Chlamydia trachomatis

    Directory of Open Access Journals (Sweden)

    Michael G. Potroz

    2015-03-01

    Full Text Available The neglected tropical disease (NTD trachoma is currently the leading cause of eye disease in the world, and the pathogenic bacteria causing this condition, Chlamydia trachomatis, is also the most common sexually transmitted pathogenic bacterium. Although the serovars of this bacterial species typically vary between ocular and genital infections there is a clear connection between genital C. trachomatis infections and the development of trachoma in infants, such that the solutions to these infections are closely related. It is the unique life cycle of the C. trachomatis bacteria which primarily leads to chronic infections and challenges in treatment using conventional antibiotics. This life cycle involves stages of infective elementary bodies (EBs and reproductive reticulate bodies (RBs. Most antibiotics only target the reproductive RBs and this often leads to the need for prolonged therapy which facilitates the development of drug resistant pathogens. It is through combining several compounds to obtain multiple antimicrobial mechanisms that we are most likely to develop a reliable means to address all these issues. Traditional and ethnobotanical medicine provides valuable resources for the development of novel formulations and treatment regimes based on synergistic and multi-compound therapy. In this review we intend to summarize the existing literature on the application of natural compounds for controlling trachoma and inhibiting chlamydial bacteria and explore the potential for the development of new treatment modalities.

  12. NMR structural studies of oligosaccharides and other natural products

    DEFF Research Database (Denmark)

    Kjærulff, Louise

    produce secondary metabolites for signaling and competing against other organisms, and these molecules are important in drug discovery due to their inherent biological activities. From a marine Photobacterium (P. halotolerans) we isolated the solonamides and the ngercheumicins, two families of cyclic...... through the nJCH correlation, this experiment has exciting applications for configurational assignment of e.g. carbohydrates and for residual dipolar couplings. Identification of known molecules and discovery of novel molecules are other important applications of NMR spectroscopy. Bacteria and fungi....... fijiensis, was also investigated for production of novel secondary metabolites, and a new pyranonigrin (E) was isolated and structure elucidated by NMR spectroscopy along with JBIR-74 and decumbenone A, two known metabolites previously isolated from Aspergillus and Penicillium species. Oligosaccharides...

  13. Direct capture and heterologous expression of Salinispora natural product genes for the biosynthesis of enterocin.

    Science.gov (United States)

    Bonet, Bailey; Teufel, Robin; Crüsemann, Max; Ziemert, Nadine; Moore, Bradley S

    2015-03-27

    Heterologous expression of secondary metabolic pathways is a promising approach for the discovery and characterization of bioactive natural products. Herein we report the first heterologous expression of a natural product from the model marine actinomycete genus Salinispora. Using the recently developed method of yeast-mediated transformation-associated recombination for natural product gene clusters, we captured a type II polyketide synthase pathway from Salinispora pacifica with high homology to the enterocin pathway from Streptomyces maritimus and successfully produced enterocin in two different Streptomyces host strains. This result paves the way for the systematic interrogation of Salinispora's promising secondary metabolome.

  14. Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms.

    Science.gov (United States)

    Büschleb, Martin; Dorich, Stéphane; Hanessian, Stephen; Tao, Daniel; Schenthal, Kyle B; Overman, Larry E

    2016-03-18

    Strategies for the total synthesis of complex natural products that contain two or more contiguous stereogenic quaternary carbon atoms in their intricate structures are reviewed with 12 representative examples. Emphasis has been put on methods to create quaternary carbon stereocenters, including syntheses of the same natural product by different groups, thereby showcasing the diversity of thought and individual creativity. A compendium of selected natural products containing two or more contiguous stereogenic quaternary carbon atoms and key reactions in their total or partial syntheses is provided in the Supporting Information. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Intrinsic antecedents of academic research productivity of a large ...

    African Journals Online (AJOL)

    Kirstam

    1South Africa faces a host of challenges in its pursuit of research productivity ( ... doctorates in South African higher education institutions, are examples of these ..... A specific tension exists in academic contexts: the tension between teaching.

  16. Research on Hydrophilic Nature of Polyvinylpyrrolidone on Polysulfone Membrane Filtration

    Science.gov (United States)

    Tiron, L. G.; Vlad, M.; Baltă, Ş.

    2018-06-01

    The membranes used in wastewater filtration are obtained from polymers, this technique is widely applied because of the small installations and low costs as against conventional systems. The polymeric membranes have high mechanical strength and flexibility, but is a challenge to improve in the same time the permeability and retention capacity of the membranes. A process that can improve the membrane properties is the addition of additives to the polymer solution, resulting in noticeable changes in the resulting membrane structure. Polyvinylpyrrolidone (PVP) is a highly hydrophilic polymer, used as a food additive that acts as stabilizer and thickening agent, which brings improvements in membrane properties. This study analyses the effect of polyvinylpyrrolidone (PVP) on the casting solution of the prepared membranes. The polymer solution was prepared from polysulfone (PSf) and N-methyl-2-pyrrolidone (NMP) at different concentrations. The membranes were obtained by phase inversion method. The PSf/PVP/NMP membranes with different concentrations were characterized by contact angle measurements, surface roughness, morphological structure and permeation tests. The results show that the hydrophilic nature of PVP improve the pure water flux, the contact angle and exhibit a higher anti-fouling property.

  17. Natural analogue studies as supplements to biomineralization research

    International Nuclear Information System (INIS)

    McNeil, M.B.

    1995-01-01

    Chemical reactions can alter the chemistry and crystal structure of solid objects over archeological or geological times, while preserving external physical shapes. The reactions resulting in these structures offer natural analogues to laboratory experiments in biomineralization and to biologically influenced alteration of nuclear waste packages, and thus, they offer the only available way of validating models that purport waste package behavior over archaeological or geological times. Potential uses of such analogues in the construction and validation of hypothetical mechanisms of microbiological corrosion and biomineralization are reviewed. Evidence from such analogues suggests that biofilms can control materials alteration in ways usually overlooked. The newly hypothesized mechanisms involve control by biofilms of the cation flow near the solid surface and offer plausible mechanisms for the formation of mixed-cation minerals under conditions that would lead to dealloying in abiotic experiments; they also account for the formation of unusual minerals [such as posnjakite, Cu 4 SO 4 (OH) 6· H 2 O] and mineral morphologies unusual in corrosion [malachite, Cu 2 CO 3 (OH) 2 , rarely forms botryoidally under corrosion conditions and its occasional presence on archaeological objects that appear to have undergone microbiological corrosion may be related to biofilm phenomena

  18. A Participatory Action Research Study of Nature Education in Nature: Towards Community-Based Eco-Pedagogy

    Science.gov (United States)

    Eryaman, Mustafa Yunus; Yalcin-Ozdilek, Sukran; Okur, Emel; Cetinkaya, Zeynep; Uygun, Selcuk

    2010-01-01

    Contemporary nature education is exploring different ways to develop awareness for change and initiate action. Such educational activities go beyond creating understanding and awareness in order to develop a sense of commitment for individual and collective action. This participatory action research study aimed to improve teachers' sensitiveness…

  19. Ground-breaking virtual research in product development

    DEFF Research Database (Denmark)

    Søndergaard, Helle Alsted; Jespersen, Kristina Risom; Buck, Nuka

    2008-01-01

    MAPP also focuses on virtual reality. In the research project RIPS - the Role of Information Processing in NPD Strategy - a simulation of a product development process was used as a data collection instrument.......MAPP also focuses on virtual reality. In the research project RIPS - the Role of Information Processing in NPD Strategy - a simulation of a product development process was used as a data collection instrument....

  20. Research governance and scientific knowledge production in The Gambia

    OpenAIRE

    Frederick U. Ozor

    2014-01-01

    Public research institutions and scientists are principal actors in the production and transfer of scientific knowledge, technologies and innovations for application in industry as well for social and economic development. Based on the relevance of science and technology actors, the aim of this study was to identify and explain factors in research governance that influence scientific knowledge production and to contribute to empirical discussions on the impact levels of different governance m...