How to Construct a Mixed Methods Research Design

OpenAIRE

Schoonenboom, Judith; Johnson, R. Burke

2017-01-01

This article provides researchers with knowledge of how to design a high quality mixed methods research study. To design a mixed study, researchers must understand and carefully consider each of the dimensions of mixed methods design, and always keep an eye on the issue of validity. We explain the seven major design dimensions: purpose, theoretical drive, timing (simultaneity and dependency), point of integration, typological versus interactive design approaches, planned versus emergent desig...

Addressing Research Design Problem in Mixed Methods Research

Science.gov (United States)

Alavi, Hamed; Hąbek, Patrycja

2016-03-01

Alongside other disciplines in social sciences, management researchers use mixed methods research more and more in conduct of their scientific investigations. Mixed methods approach can also be used in the field of production engineering. In comparison with traditional quantitative and qualitative research methods, reasons behind increasing popularity of mixed research method in management science can be traced in different factors. First of all, any particular discipline in management can be theoretically related to it. Second is that concurrent approach of mixed research method to inductive and deductive research logic provides researchers with opportunity to generate theory and test hypothesis in one study simultaneously. In addition, it provides a better justification for chosen method of investigation and higher validity for obtained answers to research questions. Despite increasing popularity of mixed research methods among management scholars, there is still need for a comprehensive approach to research design typology and process in mixed research method from the perspective of management science. The authors in this paper try to explain fundamental principles of mixed research method, its typology and different steps in its design process.

Design Research between Design and Research

DEFF Research Database (Denmark)

Steinø, Nicolai; Markussen, Thomas

2011-01-01

The discourse on architecture and design research in Denmark in the past thirty years has been stuck in a unproductive dichotomy between research through design on the one hand and a phantom image of academic and theoretical, word-based research on the other. Advocates of the research through...... design strand have argued, that architecture and design research must follow an architecture and design methodology – designing – and be communicated by means of architecture and design media – images and artefacts. Essentially, this view sees no difference between architecture and design research...... and practice, as expressed in the notion of research as ‘artistic innovation work’. On the other hand, the pressure to expand research in architecture and design has seen a movement towards adopting traditional research paradigms from the technical and social sciences and humanities. For many architects...

Employing Design and Development Research (DDR): Approaches in the Design and Development of Online Arabic Vocabulary Learning Games Prototype

Science.gov (United States)

Sahrir, Muhammad Sabri; Alias, Nor Aziah; Ismail, Zawawi; Osman, Nurulhuda

2012-01-01

The design and development research, first proposed by Brown and Collins in the 1990s, is currently among the well-known methods in educational research to test theory and validate its practicality. The method is also known as developmental research, design research, design-based research, formative research and design-cased and possesses…

Triangulation, Respondent Validation, and Democratic Participation in Mixed Methods Research

Science.gov (United States)

Torrance, Harry

2012-01-01

Over the past 10 years or so the "Field" of "Mixed Methods Research" (MMR) has increasingly been exerting itself as something separate, novel, and significant, with some advocates claiming paradigmatic status. Triangulation is an important component of mixed methods designs. Triangulation has its origins in attempts to validate research findings…

How to Construct a Mixed Methods Research Design.

Science.gov (United States)

Schoonenboom, Judith; Johnson, R Burke

2017-01-01

This article provides researchers with knowledge of how to design a high quality mixed methods research study. To design a mixed study, researchers must understand and carefully consider each of the dimensions of mixed methods design, and always keep an eye on the issue of validity. We explain the seven major design dimensions: purpose, theoretical drive, timing (simultaneity and dependency), point of integration, typological versus interactive design approaches, planned versus emergent design, and design complexity. There also are multiple secondary dimensions that need to be considered during the design process. We explain ten secondary dimensions of design to be considered for each research study. We also provide two case studies showing how the mixed designs were constructed.

Design Research: Aesthetic Epistemology and Explanatory Knowledge

Directory of Open Access Journals (Sweden)

Peter Murphy

Full Text Available The article explores the “what” and the “how” of design research. It discusses the epistemological assumptions of design and design research—the conception of true knowledge that underpins the quest to advance design knowledge through research. The article also examines the media and methods of doing design research—that is, the “how” of such research. As it developed over the past century, the design field has drawn extensively on three pivotal but often tacitly deployed epistemologies: the Platonic-Aristotelian, the pragmatic, and the postmodern. Platonic epistemology is latent in many commonplace design instruction texts. Pragmatic epistemology underscores the industrial-arts ethos of design. Postmodern epistemologies dominate in university programs—especially graduate and Ph.D. programs. The article considers how these competing epistemologies understand the role of imagination in the act of creation. The article then considers the role of explanation in the carrying out of research in creative design and arts fields. It addresses whether, and to what degree, design research ought to rely on explanatory words as its principal medium of research, or whether it is valid to substitute artifactual creation for intellectual explanation in the research process. Key words: Epistemology, Design, Imagination, Knowledge, Explanation, Practice-based research

Selecting and Improving Quasi-Experimental Designs in Effectiveness and Implementation Research.

Science.gov (United States)

Handley, Margaret A; Lyles, Courtney R; McCulloch, Charles; Cattamanchi, Adithya

2018-04-01

Interventional researchers face many design challenges when assessing intervention implementation in real-world settings. Intervention implementation requires holding fast on internal validity needs while incorporating external validity considerations (such as uptake by diverse subpopulations, acceptability, cost, and sustainability). Quasi-experimental designs (QEDs) are increasingly employed to achieve a balance between internal and external validity. Although these designs are often referred to and summarized in terms of logistical benefits, there is still uncertainty about (a) selecting from among various QEDs and (b) developing strategies to strengthen the internal and external validity of QEDs. We focus here on commonly used QEDs (prepost designs with nonequivalent control groups, interrupted time series, and stepped-wedge designs) and discuss several variants that maximize internal and external validity at the design, execution and implementation, and analysis stages.

5th International Conference on Research into Design

CERN Document Server

2015-01-01

This book showcases cutting-edge research papers from the 5th International Conference on Research into Design – the largest in India in this area – written by eminent researchers from across the world on design process, technologies, methods and tools, and their impact on innovation, for supporting design across boundaries. The special features of the book are the variety of insights into the product and system innovation process, and the host of methods and tools from all major areas of design research for the enhancement of the innovation process. The main benefit of the book for researchers in various areas of design and innovation are access to the latest quality research in this area, with the largest collection of research from India. For practitioners and educators, it is exposure to an empirically validated suite of theories, models, methods and tools that can be taught and practiced for design-led innovation.

Achieving external validity in home advantage research: generalizing crowd noise effects

Directory of Open Access Journals (Sweden)

Tony D Myers

2014-06-01

Full Text Available Different factors have been postulated to explain the home advantage phenomenon in sport. One plausible explanation investigated has been the influence of a partisan home crowd on sports officials’ decisions. Different types of studies have tested the crowd influence hypothesis including purposefully designed experiments. However, while experimental studies investigating crowd influences have high levels of internal validity, they suffer from a lack of external validity; decision-making in a laboratory setting bearing little resemblance to decision-making in live sports settings. This focused review initially considers threats to external validity in applied and theoretical experimental research. Discussing how such threats can be addressed using representative design by focusing on a recently published study that arguably provides the first experimental evidence of the impact of live crowd noise on officials in sport. The findings of this controlled experiment conducted in a real tournament setting offer some confirmation of the validity of laboratory experimental studies in the area. Finally directions for future research and the future conduct of crowd noise studies are discussed.

Design and validation of general biology learning program based on scientific inquiry skills

Science.gov (United States)

Cahyani, R.; Mardiana, D.; Noviantoro, N.

2018-03-01

Scientific inquiry is highly recommended to teach science. The reality in the schools and colleges is that many educators still have not implemented inquiry learning because of their lack of understanding. The study aims to1) analyze students’ difficulties in learning General Biology, 2) design General Biology learning program based on multimedia-assisted scientific inquiry learning, and 3) validate the proposed design. The method used was Research and Development. The subjects of the study were 27 pre-service students of general elementary school/Islamic elementary schools. The workflow of program design includes identifying learning difficulties of General Biology, designing course programs, and designing instruments and assessment rubrics. The program design is made for four lecture sessions. Validation of all learning tools were performed by expert judge. The results showed that: 1) there are some problems identified in General Biology lectures; 2) the designed products include learning programs, multimedia characteristics, worksheet characteristics, and, scientific attitudes; and 3) expert validation shows that all program designs are valid and can be used with minor revisions. The first section in your paper.

Domestic design and validation of natural circulation steam generator of China 1000 MWe PWR NPP

International Nuclear Information System (INIS)

Liu, H.Y.; Wang, X.Y.; Wu, G.; Qin, J.M.; Xiong, Ch.H.; Wang, W.; Chen, J.L.; Cheng, H.P.; Zuo, Ch.P.

2005-01-01

In order to meet the requirements of domestic design of China intending built NPP projects, Research Institute of Nuclear Power Operation (RINPO) has achieved design of 1000 MWe NPP steam generator, called RINSG-1000(means 1000MWe SG designed by RINPO), which is based on SG research ,experiments and service experience accumulated by RINPO in more 40 years. Testing validation of two steam generator key technologies, advanced moisture separate device and sludge collector, has been accomplished during the period of 2000 to 2002. This paper describes the design features of RINSG-1000, and provides some validation test results. (authors)

Rapid Robot Design Validation, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — Energid Technologies will create a comprehensive software infrastructure for rapid validation of robot designs. The software will support push-button validation...

Design and validation of a comprehensive fecal incontinence questionnaire.

Science.gov (United States)

Macmillan, Alexandra K; Merrie, Arend E H; Marshall, Roger J; Parry, Bryan R

2008-10-01

Fecal incontinence can have a profound effect on quality of life. Its prevalence remains uncertain because of stigma, lack of consistent definition, and dearth of validated measures. This study was designed to develop a valid clinical and epidemiologic questionnaire, building on current literature and expertise. Patients and experts undertook face validity testing. Construct validity, criterion validity, and test-retest reliability was undertaken. Construct validity comprised factor analysis and internal consistency of the quality of life scale. The validity of known groups was tested against 77 control subjects by using regression models. Questionnaire results were compared with a stool diary for criterion validity. Test-retest reliability was calculated from repeated questionnaire completion. The questionnaire achieved good face validity. It was completed by 104 patients. The quality of life scale had four underlying traits (factor analysis) and high internal consistency (overall Cronbach alpha = 0.97). Patients and control subjects answered the questionnaire significantly differently (P validity testing. Criterion validity assessment found mean differences close to zero. Median reliability for the whole questionnaire was 0.79 (range, 0.35-1). This questionnaire compares favorably with other available instruments, although the interpretation of stool consistency requires further research. Its sensitivity to treatment still needs to be investigated.

Validity and Reliability in Social Science Research

Science.gov (United States)

Drost, Ellen A.

2011-01-01

In this paper, the author aims to provide novice researchers with an understanding of the general problem of validity in social science research and to acquaint them with approaches to developing strong support for the validity of their research. She provides insight into these two important concepts, namely (1) validity; and (2) reliability, and…

Achieving external validity in home advantage research: generalizing crowd noise effects.

Science.gov (United States)

Myers, Tony D

2014-01-01

Different factors have been postulated to explain the home advantage phenomenon in sport. One plausible explanation investigated has been the influence of a partisan home crowd on sports officials' decisions. Different types of studies have tested the crowd influence hypothesis including purposefully designed experiments. However, while experimental studies investigating crowd influences have high levels of internal validity, they suffer from a lack of external validity; decision-making in a laboratory setting bearing little resemblance to decision-making in live sports settings. This focused review initially considers threats to external validity in applied and theoretical experimental research. Discussing how such threats can be addressed using representative design by focusing on a recently published study that arguably provides the first experimental evidence of the impact of live crowd noise on officials in sport. The findings of this controlled experiment conducted in a real tournament setting offer a level of confirmation of the findings of laboratory studies in the area. Finally directions for future research and the future conduct of crowd noise studies are discussed.

On validation of the rain climatic zone designations for Nigeria

Science.gov (United States)

Obiyemi, O. O.; Ibiyemi, T. S.; Ojo, J. S.

2017-07-01

In this paper, validation of rain climatic zone classifications for Nigeria is presented based on global radio-climatic models by the International Telecommunication Union-Radiocommunication (ITU-R) and Crane. Rain rate estimates deduced from several ground-based measurements and those earlier estimated from the precipitation index on the Tropical Rain Measurement Mission (TRMM) were employed for the validation exercise. Although earlier classifications indicated that Nigeria falls into zones P, Q, N, and K for the ITU-R designations, and zones E and H for Crane's climatic zone designations, the results however confirmed that the rain climatic zones across Nigeria can only be classified into four, namely P, Q, M, and N for the ITU-R designations, while the designations by Crane exhibited only three zones, namely E, G, and H. The ITU-R classification was found to be more suitable for planning microwave and millimeter wave links across Nigeria. The research outcomes are vital in boosting the confidence level of system designers in using the ITU-R designations as presented in the map developed for the rain zone designations for estimating the attenuation induced by rain along satellite and terrestrial microwave links over Nigeria.

Design, Research, and Design Research: Synergies and Contradictions

Science.gov (United States)

Nelson, Wayne A.

2013-01-01

Notions of design, research, and design research in the field of educational technology are quite different from conceptualizations held by other design fields. Examining the ways that research is conducted and used in educational technology in comparison to other design fields can provide novel insights into how research and design practice can…

A Simulation Study of Threats to Validity in Quasi-Experimental Designs: Interrelationship between Design, Measurement, and Analysis.

Science.gov (United States)

Holgado-Tello, Fco P; Chacón-Moscoso, Salvador; Sanduvete-Chaves, Susana; Pérez-Gil, José A

2016-01-01

The Campbellian tradition provides a conceptual framework to assess threats to validity. On the other hand, different models of causal analysis have been developed to control estimation biases in different research designs. However, the link between design features, measurement issues, and concrete impact estimation analyses is weak. In order to provide an empirical solution to this problem, we use Structural Equation Modeling (SEM) as a first approximation to operationalize the analytical implications of threats to validity in quasi-experimental designs. Based on the analogies established between the Classical Test Theory (CTT) and causal analysis, we describe an empirical study based on SEM in which range restriction and statistical power have been simulated in two different models: (1) A multistate model in the control condition (pre-test); and (2) A single-trait-multistate model in the control condition (post-test), adding a new mediator latent exogenous (independent) variable that represents a threat to validity. Results show, empirically, how the differences between both the models could be partially or totally attributed to these threats. Therefore, SEM provides a useful tool to analyze the influence of potential threats to validity.

Guided exploration of physically valid shapes for furniture design

KAUST Repository

Umetani, Nobuyuki

2012-07-01

Geometric modeling and the physical validity of shapes are traditionally considered independently. This makes creating aesthetically pleasing yet physically valid models challenging. We propose an interactive design framework for efficient and intuitive exploration of geometrically and physically valid shapes. During any geometric editing operation, the proposed system continuously visualizes the valid range of the parameter being edited. When one or more constraints are violated after an operation, the system generates multiple suggestions involving both discrete and continuous changes to restore validity. Each suggestion also comes with an editing mode that simultaneously adjusts multiple parameters in a coordinated way to maintain validity. Thus, while the user focuses on the aesthetic aspects of the design, our computational design framework helps to achieve physical realizability by providing active guidance to the user. We demonstrate our framework on plankbased furniture design with nail-joint and frictional constraints. We use our system to design a range of examples, conduct a user study, and also fabricate a physical prototype to test the validity and usefulness of the system. © 2012 ACM 0730-0301/2012/08- ART86.

F-18 High Alpha Research Vehicle (HARV) parameter identification flight test maneuvers for optimal input design validation and lateral control effectiveness

Science.gov (United States)

Morelli, Eugene A.

1995-01-01

Flight test maneuvers are specified for the F-18 High Alpha Research Vehicle (HARV). The maneuvers were designed for open loop parameter identification purposes, specifically for optimal input design validation at 5 degrees angle of attack, identification of individual strake effectiveness at 40 and 50 degrees angle of attack, and study of lateral dynamics and lateral control effectiveness at 40 and 50 degrees angle of attack. Each maneuver is to be realized by applying square wave inputs to specific control effectors using the On-Board Excitation System (OBES). Maneuver descriptions and complete specifications of the time/amplitude points define each input are included, along with plots of the input time histories.

Ensuring validity in qualitative international business research

DEFF Research Database (Denmark)

Andersen, Poul Houman; Skaates, Maria Anne

2002-01-01

The purpose of this paper is to provide an account of how the validity issue related to qualitative research strategies within the IB field may be grasped from an at least partially subjectivist point of view. In section two, we will first assess via the aforementioned literature review the extent...... to which the validity issue has been treated in qualitative research contributions published in six leading English-language journals which publish IB research. Thereafter, in section three, we will discuss our findings and relate them to (a) various levels of a research project and (b) the existing...... literature on potential validity problems from a more subjectivist point of view. As a part of this step, we will demonstrate that the assumptions of objectivist and subjectivist ontologies and their corresponding epistemologies merit different canons for assessing research validity. In the subsequent...

Design and validation of Segment - freely available software for cardiovascular image analysis

International Nuclear Information System (INIS)

Heiberg, Einar; Sjögren, Jane; Ugander, Martin; Carlsson, Marcus; Engblom, Henrik; Arheden, Håkan

2010-01-01

Commercially available software for cardiovascular image analysis often has limited functionality and frequently lacks the careful validation that is required for clinical studies. We have already implemented a cardiovascular image analysis software package and released it as freeware for the research community. However, it was distributed as a stand-alone application and other researchers could not extend it by writing their own custom image analysis algorithms. We believe that the work required to make a clinically applicable prototype can be reduced by making the software extensible, so that researchers can develop their own modules or improvements. Such an initiative might then serve as a bridge between image analysis research and cardiovascular research. The aim of this article is therefore to present the design and validation of a cardiovascular image analysis software package (Segment) and to announce its release in a source code format. Segment can be used for image analysis in magnetic resonance imaging (MRI), computed tomography (CT), single photon emission computed tomography (SPECT) and positron emission tomography (PET). Some of its main features include loading of DICOM images from all major scanner vendors, simultaneous display of multiple image stacks and plane intersections, automated segmentation of the left ventricle, quantification of MRI flow, tools for manual and general object segmentation, quantitative regional wall motion analysis, myocardial viability analysis and image fusion tools. Here we present an overview of the validation results and validation procedures for the functionality of the software. We describe a technique to ensure continued accuracy and validity of the software by implementing and using a test script that tests the functionality of the software and validates the output. The software has been made freely available for research purposes in a source code format on the project home page (http://segment.heiberg.se). Segment

Design and Control of Compliant Tensegrity Robots Through Simulation and Hardware Validation

Science.gov (United States)

Caluwaerts, Ken; Despraz, Jeremie; Iscen, Atil; Sabelhaus, Andrew P.; Bruce, Jonathan; Schrauwen, Benjamin; Sunspiral, Vytas

2014-01-01

To better understand the role of tensegrity structures in biological systems and their application to robotics, the Dynamic Tensegrity Robotics Lab at NASA Ames Research Center has developed and validated two different software environments for the analysis, simulation, and design of tensegrity robots. These tools, along with new control methodologies and the modular hardware components developed to validate them, are presented as a system for the design of actuated tensegrity structures. As evidenced from their appearance in many biological systems, tensegrity ("tensile-integrity") structures have unique physical properties which make them ideal for interaction with uncertain environments. Yet these characteristics, such as variable structural compliance, and global multi-path load distribution through the tension network, make design and control of bio-inspired tensegrity robots extremely challenging. This work presents the progress in using these two tools in tackling the design and control challenges. The results of this analysis includes multiple novel control approaches for mobility and terrain interaction of spherical tensegrity structures. The current hardware prototype of a six-bar tensegrity, code-named ReCTeR, is presented in the context of this validation.

Design Research

DEFF Research Database (Denmark)

Design Research is a new interdisciplinary research area with a social science orientation at its heart, and this book explores how scientific knowledge can be put into practice in ways that are at once ethical, creative, helpful, and extraordinary in their results. In order to clarify the common...... aspects – in terms of features and approaches – that characterize all strands of research disciplines addressing design, Design Research undertakes an in depth exploration of the social processes involved in doing design, as well as analyses of the contexts for design use. The book further elicits...... ‘synergies from interdisciplinary perspectives’ by discussing and elaborating on differing academic perspectives, theoretical backgrounds, and design concept definitions, and evaluating their unique contribution to a general core of design research. This book is an exciting contribution to this little...

Automatic control system generation for robot design validation

Science.gov (United States)

Bacon, James A. (Inventor); English, James D. (Inventor)

2012-01-01

The specification and drawings present a new method, system and software product for and apparatus for generating a robotic validation system for a robot design. The robotic validation system for the robot design of a robotic system is automatically generated by converting a robot design into a generic robotic description using a predetermined format, then generating a control system from the generic robotic description and finally updating robot design parameters of the robotic system with an analysis tool using both the generic robot description and the control system.

Choosing an adequate design and analysis in cross-cultural personality research

Directory of Open Access Journals (Sweden)

Jia He

2017-02-01

Full Text Available The flourishing of cross-cultural personality research requires a keen eye for rigorous methodology in such research. With decades of experience in cross-cultural research methods, we have come to appreciate that methodological aspects of such studies are critical for obtaining valid findings. Ill-designed or -conducted studies may produce results that are difficult to interpret. A careful design and analysis can help to deal with various methodological problems in cross-cultural personality studies. Drawing on the extensive knowledge that has been accumulated in cross-cultural and personality research in the past decades, we describe a framework of bias and equivalence that enables the choice of adequate research methods and the avoidance of pitfalls that endanger valid conclusions in cross-cultural personality research. Specifically, we focus on sampling issues, test adaptations, and the combination of emic and etic approaches in this short review article. We encourage researchers to use the tools and experience that are available to considerably enlarge our insights in cross-cultural differences and similarities in personality research.

Design and analysis of post-marketing research.

Science.gov (United States)

Zhou, Xiao-Hua Andrew; Yang, Wei

2013-07-01

A post-marketing study is an integral part of research that helps to ensure a favorable risk-benefit profile for approved drugs used in the market. Because most of post-marketing studies use observational designs, which are liable to confounding, estimation of the causal effect of a drug versus a comparative one is very challenging. This article focuses on methodological issues of importance in designing and analyzing studies to evaluate the safety of marketed drugs, especially marketed traditional Chinese medicine (TCM) products. Advantages and limitations of the current designs and analytic methods for postmarketing studies are discussed, and recommendations are given for improving the validity of postmarketing studies in TCM products.

Integrated Design Validation: Combining Simulation and Formal Verification for Digital Integrated Circuits

Directory of Open Access Journals (Sweden)

Lun Li

2006-04-01

Full Text Available The correct design of complex hardware continues to challenge engineers. Bugs in a design that are not uncovered in early design stages can be extremely expensive. Simulation is a predominantly used tool to validate a design in industry. Formal verification overcomes the weakness of exhaustive simulation by applying mathematical methodologies to validate a design. The work described here focuses upon a technique that integrates the best characteristics of both simulation and formal verification methods to provide an effective design validation tool, referred as Integrated Design Validation (IDV. The novelty in this approach consists of three components, circuit complexity analysis, partitioning based on design hierarchy, and coverage analysis. The circuit complexity analyzer and partitioning decompose a large design into sub-components and feed sub-components to different verification and/or simulation tools based upon known existing strengths of modern verification and simulation tools. The coverage analysis unit computes the coverage of design validation and improves the coverage by further partitioning. Various simulation and verification tools comprising IDV are evaluated and an example is used to illustrate the overall validation process. The overall process successfully validates the example to a high coverage rate within a short time. The experimental result shows that our approach is a very promising design validation method.

Toward a Unified Validation Framework in Mixed Methods Research

Science.gov (United States)

Dellinger, Amy B.; Leech, Nancy L.

2007-01-01

The primary purpose of this article is to further discussions of validity in mixed methods research by introducing a validation framework to guide thinking about validity in this area. To justify the use of this framework, the authors discuss traditional terminology and validity criteria for quantitative and qualitative research, as well as…

Waste Isolation Pilot Plant design validation: Final report

International Nuclear Information System (INIS)

1986-10-01

This report provides documentation of actual underground conditions encountered as they relate to the design criteria, design bases, and design configurations for the reference design of the underground openings. It includes a selection of the more essential data collected during the design validation effort and an interpretation of these data

Design Science Research For Personal Knowledge Management System Development - Revisited

Directory of Open Access Journals (Sweden)

Ulrich Schmitt

2016-11-01

Thirdly, the development process and resulting prototype are verified against accepted general design science research (DSR guidelines. DSR aims at creating innovative IT artifacts (that extend human and social capabilities and meet desired outcomes and at validating design processes (as evidence of their relevance, utility, rigor, resonance, and publishability. Together with the incorporated references to around thirty prior publications covering technical and methodological details, a kind of ‘Long Discussion Case’ emerges aiming to potentially assist IT researchers and entrepreneurs engaged in similar projects.

VALUE - Validating and Integrating Downscaling Methods for Climate Change Research

Science.gov (United States)

Maraun, Douglas; Widmann, Martin; Benestad, Rasmus; Kotlarski, Sven; Huth, Radan; Hertig, Elke; Wibig, Joanna; Gutierrez, Jose

2013-04-01

Our understanding of global climate change is mainly based on General Circulation Models (GCMs) with a relatively coarse resolution. Since climate change impacts are mainly experienced on regional scales, high-resolution climate change scenarios need to be derived from GCM simulations by downscaling. Several projects have been carried out over the last years to validate the performance of statistical and dynamical downscaling, yet several aspects have not been systematically addressed: variability on sub-daily, decadal and longer time-scales, extreme events, spatial variability and inter-variable relationships. Different downscaling approaches such as dynamical downscaling, statistical downscaling and bias correction approaches have not been systematically compared. Furthermore, collaboration between different communities, in particular regional climate modellers, statistical downscalers and statisticians has been limited. To address these gaps, the EU Cooperation in Science and Technology (COST) action VALUE (www.value-cost.eu) has been brought into life. VALUE is a research network with participants from currently 23 European countries running from 2012 to 2015. Its main aim is to systematically validate and develop downscaling methods for climate change research in order to improve regional climate change scenarios for use in climate impact studies. Inspired by the co-design idea of the international research initiative "future earth", stakeholders of climate change information have been involved in the definition of research questions to be addressed and are actively participating in the network. The key idea of VALUE is to identify the relevant weather and climate characteristics required as input for a wide range of impact models and to define an open framework to systematically validate these characteristics. Based on a range of benchmark data sets, in principle every downscaling method can be validated and compared with competing methods. The results of

An introduction to design-based research with an example from statistics education

NARCIS (Netherlands)

Bakker, Arthur|info:eu-repo/dai/nl/272605778; van Eerde, Henriette|info:eu-repo/dai/nl/071855343

2015-01-01

This chapter arose from the need to introduce researchers, including Master and PhD students, to design-based research (DBR). In Part 1 we address key features of DBR and differences from other research approaches. We also describe the meaning of validity and reliability in DBR and discuss how they

Research-based design & design-based research: Affordances, limitations and synergies

NARCIS (Netherlands)

McKenney, Susan

2015-01-01

Research-based design is an orientation to educational development that is explicitly informed by existing research as well as formative evaluation. Design-based research is a genre of inquiry in which the design of innovative solutions to problems in educational practice provides the context for

Design Research as Conceptual Designing

DEFF Research Database (Denmark)

Ylirisku, Salu; Jacucci, Giulio; Sellen, Abigail

2015-01-01

define conceptual designing as a constructive framing and re-framing activity, which is mediated by and targeted at the creation of new design concepts. Conceptual designing as an approach is valuable for addressing the fuzziness and ambiguity typical of research that explores novel areas with new...... partners, methods and resources. It is by no means a new phenomenon, and the main contribution of the article is the clarification of conceptual designing as a particular approach to designing and researching. The approach embraces openness, resource-construction and collaboration. We conclude...... that conceptual designing can be especially useful in research and design projects that bring different kinds of people, organizations, technologies and domains together into the forming of new well-founded proposals for development. The presentation of conceptual designing in this paper is written...

Reflection: Research by Design: Design-Based Research and the Higher Degree Research Student

Science.gov (United States)

Kennedy-Clark, Shannon

2015-01-01

The article "Research by design: Design-based research and the higher degree research student" (Kennedy-Clark, 2013) appeared in the "Journal of Learning Design" Volume 6, Issue 2 in 2013. Two years on, Shannon Kennedy-Clark reflects upon her original article. Upon being asked to revisit this article the author reflected upon…

Development strategy and conceptual design of China Lead-based Research Reactor

International Nuclear Information System (INIS)

Wu, Yican; Bai, Yunqing; Song, Yong; Huang, Qunying; Zhao, Zhumin; Hu, Liqin

2016-01-01

Highlights: • China LEAd-based Reactor (CLEAR) proposed by Institute of Nuclear Energy Safety Technology (INEST) is selected as the ADS reference reactor. • The Chinese ADS development program consists of three stages, and during the first stage, a 10 MW th lead-based research reactor named CLEAR-I will be built with subcritical and critical dual-mode operation capability for validation of ADS transmutation system and lead cooled fast reactor technology. • Major design principles of CLEAR-I are oriented at technology feasibility, safety reliability, experiment flexibility and technology continuity. Followed by the development strategy and design principles, CLEAR-I design options and conceptual design scenarios are presented. - Abstract: Chinese Academy of Sciences (CAS) launched an engineering project to develop an Accelerator Driven System (ADS) for nuclear waste transmutation since 2011, and China LEAd-based Reactor (CLEAR) proposed by Institute of Nuclear Energy Safety Technology (INEST) is selected as the ADS reference reactor. In this paper, the development strategy and conceptual design of China Lead-based Research Reactor are proposed. The Chinese ADS development program consists of three stages, and during the first stage, a 10 MW th lead-based research reactor named CLEAR-I will be built with subcritical and critical dual-mode operation capability for validation of ADS transmutation system and lead cooled fast reactor technology. Major design principles of CLEAR-I are oriented at technology feasibility, safety reliability, experiment flexibility and technology continuity. Followed by the development strategy and design principles, CLEAR-I design options and conceptual design scenarios are presented.

Designing Difference in Difference Studies: Best Practices for Public Health Policy Research.

Science.gov (United States)

Wing, Coady; Simon, Kosali; Bello-Gomez, Ricardo A

2018-04-01

The difference in difference (DID) design is a quasi-experimental research design that researchers often use to study causal relationships in public health settings where randomized controlled trials (RCTs) are infeasible or unethical. However, causal inference poses many challenges in DID designs. In this article, we review key features of DID designs with an emphasis on public health policy research. Contemporary researchers should take an active approach to the design of DID studies, seeking to construct comparison groups, sensitivity analyses, and robustness checks that help validate the method's assumptions. We explain the key assumptions of the design and discuss analytic tactics, supplementary analysis, and approaches to statistical inference that are often important in applied research. The DID design is not a perfect substitute for randomized experiments, but it often represents a feasible way to learn about casual relationships. We conclude by noting that combining elements from multiple quasi-experimental techniques may be important in the next wave of innovations to the DID approach.

Guided exploration of physically valid shapes for furniture design

KAUST Repository

Umetani, Nobuyuki; Igarashi, Takeo; Mitra, Niloy J.

2012-01-01

Geometric modeling and the physical validity of shapes are traditionally considered independently. This makes creating aesthetically pleasing yet physically valid models challenging. We propose an interactive design framework for efficient

Validation of Helium Inlet Design for ITER Toroidal Field Coil

CERN Document Server

Boyer, C; Hamada, K; Foussat, A; Le Rest, M; Mitchell, N; Decool, P; Savary, F; Sgobba, S; Weiss, K-P

2014-01-01

The ITER organization has performed design and its validation tests on a helium inlet structure for the ITER Toroidal Field (TF) coil under collaboration with CERN, KIT, and CEA-Cadarache. Detailed structural analysis was performed in order to optimize the weld shape. A fatigue resistant design on the fillet weld between the shell covers and the jacket is an important point on the helium inlet structure. A weld filler material was selected based on tensile test at liquid helium temperature after Nb$_{3}$Sn reaction heat treatment. To validate the design of the weld joint, fatigue tests at 7 K were performed using heat-treated butt weld samples. A pressure drop measurement of a helium inlet mock-up was performed by using nitrogen gas at room temperature in order to confirm uniform flow distribution and pressure drop characteristic. These tests have validated the helium inlet design. Based on the validation, Japanese and European Union domestic agencies, which have responsibilities of the TF coil procurement, a...

Preliminary Validation and Verification of TURBO{sub D}ESIGN for S-CO{sub 2} Axial Compressor

Energy Technology Data Exchange (ETDEWEB)

Lee, Je Kyoung; Lee, Jeong Ik; Ahn, Yoon Han; Kim, Seong Gu [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Yoon, Ho Joon; Addad, Yacine [Khalifa University of Science, Technology and Research, Abu Dhabi (United Arab Emirates)

2012-05-15

To use the advantages of Supercritical CO{sub 2}(S-CO{sub 2}) Brayton cycle for nuclear power plant, KAIST-Khalifa University joint research team has been focusing on S-CO{sub 2} turbomachinery development. TURBO{sub D}ESIGN code is one of the products of our researches to design a turbomachinery. The major feature of TURBO{sub D}ESIGN is that the formulation is based on the real gas and none of the ideal gas assumption was applied to the code. Thus, TURBO{sub D}ESIGN has high flexibility regarding the type of gases. In this paper, preliminary code validation and verification of TURBO{sub D}ESIGN will be discussed for axial type compressor design

Design validation of the ITER EC upper launcher according to codes and standards

Energy Technology Data Exchange (ETDEWEB)

Spaeh, Peter, E-mail: peter.spaeh@kit.edu [Karlsruhe Institute of Technology, Institute for Applied Materials, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); Aiello, Gaetano [Karlsruhe Institute of Technology, Institute for Applied Materials, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); Gagliardi, Mario [Karlsruhe Institute of Technology, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); F4E, Fusion for Energy, Joint Undertaking, Barcelona (Spain); Grossetti, Giovanni; Meier, Andreas; Scherer, Theo; Schreck, Sabine; Strauss, Dirk; Vaccaro, Alessandro [Karlsruhe Institute of Technology, Institute for Applied Materials, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); Weinhorst, Bastian [Karlsruhe Institute of Technology, Institute for Neutron Physics and Reactor Technology, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany)

2015-10-15

Highlights: • A set of applicable codes and standards has been chosen for the ITER EC upper launcher. • For a particular component load combinations, failure modes and stress categorizations have been determined. • The design validation was performed in accordance with the “design by analysis”-approach of the ASME boiler and pressure vessel code section III. - Abstract: The ITER electron cyclotron (EC) upper launcher has passed the CDR (conceptual design review) in 2005 and the PDR (preliminary design review) in 2009 and is in its final design phase now. The final design will be elaborated by the European consortium ECHUL-CA with contributions from several research institutes in Germany, Italy, the Netherlands and Switzerland. Within this consortium KIT is responsible for the design of the structural components (the upper port plug, UPP) and also the design integration of the launcher. As the selection of applicable codes and standards was under discussion for the past decade, the conceptual and the preliminary design of the launcher structure were not elaborated in straight accordance with a particular code but with a variety of well-acknowledged engineering practices. For the final design it is compulsory to validate the design with respect to a typical engineering code in order to be compliant with the ITER quality and nuclear requirements and to get acceptance from the French regulator. This paper presents typical design validation of the closure plate, which is the vacuum and Tritium barrier and thus a safety relevant component of the upper port plug (UPP), performed with the ASME boiler and pressure vessel code. Rationales for choosing this code are given as well as a comparison between different design methods, like the “design by rule” and the “design by analysis” approach. Also the selections of proper load specifications and the identification of potential failure modes are covered. In addition to that stress categorizations, analyses

Design validation of the ITER EC upper launcher according to codes and standards

International Nuclear Information System (INIS)

Spaeh, Peter; Aiello, Gaetano; Gagliardi, Mario; Grossetti, Giovanni; Meier, Andreas; Scherer, Theo; Schreck, Sabine; Strauss, Dirk; Vaccaro, Alessandro; Weinhorst, Bastian

2015-01-01

Highlights: • A set of applicable codes and standards has been chosen for the ITER EC upper launcher. • For a particular component load combinations, failure modes and stress categorizations have been determined. • The design validation was performed in accordance with the “design by analysis”-approach of the ASME boiler and pressure vessel code section III. - Abstract: The ITER electron cyclotron (EC) upper launcher has passed the CDR (conceptual design review) in 2005 and the PDR (preliminary design review) in 2009 and is in its final design phase now. The final design will be elaborated by the European consortium ECHUL-CA with contributions from several research institutes in Germany, Italy, the Netherlands and Switzerland. Within this consortium KIT is responsible for the design of the structural components (the upper port plug, UPP) and also the design integration of the launcher. As the selection of applicable codes and standards was under discussion for the past decade, the conceptual and the preliminary design of the launcher structure were not elaborated in straight accordance with a particular code but with a variety of well-acknowledged engineering practices. For the final design it is compulsory to validate the design with respect to a typical engineering code in order to be compliant with the ITER quality and nuclear requirements and to get acceptance from the French regulator. This paper presents typical design validation of the closure plate, which is the vacuum and Tritium barrier and thus a safety relevant component of the upper port plug (UPP), performed with the ASME boiler and pressure vessel code. Rationales for choosing this code are given as well as a comparison between different design methods, like the “design by rule” and the “design by analysis” approach. Also the selections of proper load specifications and the identification of potential failure modes are covered. In addition to that stress categorizations, analyses

Validation of a new design of tellurium dioide-irradiated target

Energy Technology Data Exchange (ETDEWEB)

Fllaoui, Aziz; Ghamad, Younes; Zoubir, Brahim; Ayaz, Zinel Abidine; El Morabiti, Aissam; Amayoud, Hafid [Centre National de l' Energie des Sciences et des Techniques Nucleaires, Rabat (Morocco); Chakir, El Mahjoub [Nuclear Physics Department, University Ibn Toufail, Kenitra (Morocco)

2016-10-15

Production of iodine-131 by neutron activation of tellurium in tellurium dioxide (TeO{sub 2}) material requires a target that meets the safety requirements. In a radiopharmaceutical production unit, a new lid for a can was designed, which permits tight sealing of the target by using tungsten inert gas welding. The leakage rate of all prepared targets was assessed using a helium mass spectrometer. The accepted leakage rate is ≤ 10 - 4 mbr.L/s, according to the approved safety report related to iodine-131 production in the TRIGA Mark II research reactor (TRIGA: Training, Research, Isotopes, General Atomics). To confirm the resistance of the new design to the irradiation conditions in the TRIGA Mark II research reactor's central thimble, a study of heat effect on the sealed targets for 7 hours in an oven was conducted and the leakage rates were evaluated. The results show that the tightness of the targets is ensured up to 600 .deg. C with the appearance of deformations on lids beyond 450 .deg. C. The study of heat transfer through the target was conducted by adopting a one-dimensional approximation, under consideration of the three transfer modes-convection, conduction, and radiation. The quantities of heat generated by gamma and neutron heating were calculated by a validated computational model for the neutronic simulation of the TRIGA Mark II research reactor using the Monte Carlo N-Particle transport code. Using the heat transfer equations according to the three modes of heat transfer, the thermal study of I-131 production by irradiation of the target in the central thimble showed that the temperatures of materials do not exceed the corresponding melting points. To validate this new design, several targets have been irradiated in the central thimble according to a preplanned irradiation program, going from 4 hours of irradiation at a power level of 0.5 MW up to 35 hours (7 h/d for 5 days a week) at 1.5 MW. The results show that the irradiated targets are

Validation of a New Design of Tellurium Dioxide-Irradiated Target

Directory of Open Access Journals (Sweden)

Aziz Fllaoui

2016-10-01

Full Text Available Production of iodine-131 by neutron activation of tellurium in tellurium dioxide (TeO2 material requires a target that meets the safety requirements. In a radiopharmaceutical production unit, a new lid for a can was designed, which permits tight sealing of the target by using tungsten inert gas welding. The leakage rate of all prepared targets was assessed using a helium mass spectrometer. The accepted leakage rate is ≤ 10−4 mbr.L/s, according to the approved safety report related to iodine-131 production in the TRIGA Mark II research reactor (TRIGA: Training, Research, Isotopes, General Atomics. To confirm the resistance of the new design to the irradiation conditions in the TRIGA Mark II research reactor's central thimble, a study of heat effect on the sealed targets for 7 hours in an oven was conducted and the leakage rates were evaluated. The results show that the tightness of the targets is ensured up to 600°C with the appearance of deformations on lids beyond 450°C. The study of heat transfer through the target was conducted by adopting a one-dimensional approximation, under consideration of the three transfer modes—convection, conduction, and radiation. The quantities of heat generated by gamma and neutron heating were calculated by a validated computational model for the neutronic simulation of the TRIGA Mark II research reactor using the Monte Carlo N-Particle transport code. Using the heat transfer equations according to the three modes of heat transfer, the thermal study of I-131 production by irradiation of the target in the central thimble showed that the temperatures of materials do not exceed the corresponding melting points. To validate this new design, several targets have been irradiated in the central thimble according to a preplanned irradiation program, going from 4 hours of irradiation at a power level of 0.5 MW up to 35 hours (7 h/d for 5 days a week at 1.5 MW. The results show that the irradiated targets are

Study design elements for rigorous quasi-experimental comparative effectiveness research.

Science.gov (United States)

Maciejewski, Matthew L; Curtis, Lesley H; Dowd, Bryan

2013-03-01

Quasi-experiments are likely to be the workhorse study design used to generate evidence about the comparative effectiveness of alternative treatments, because of their feasibility, timeliness, affordability and external validity compared with randomized trials. In this review, we outline potential sources of discordance in results between quasi-experiments and experiments, review study design choices that can improve the internal validity of quasi-experiments, and outline innovative data linkage strategies that may be particularly useful in quasi-experimental comparative effectiveness research. There is an urgent need to resolve the debate about the evidentiary value of quasi-experiments since equal consideration of rigorous quasi-experiments will broaden the base of evidence that can be brought to bear in clinical decision-making and governmental policy-making.

Validation of helium inlet design for ITER toroidal field coil

International Nuclear Information System (INIS)

Boyer, C.; Seo, K.; Hamada, K.; Foussat, A.; Le Rest, M.; Mitchell, N.; Decool, P.; Savary, F.; Sgobba, S.; Weiss, K.P.

2014-01-01

The ITER organization has performed design and its validation tests on a helium inlet structure for the ITER Toroidal Field (TF) coil under collaboration with CERN, KIT, and CEA Cadarache. Detailed structural analysis was performed in order to optimize the weld shape. A fatigue resistant design on the fillet weld between the shell covers and the jacket is an important point on the helium inlet structure. A weld filler material was selected based on tensile test at liquid helium temperature after Nb 3 Sn reaction heat treatment. To validate the design of the weld joint, fatigue tests at 7 K were performed using heat-treated butt weld samples. A pressure drop measurement of a helium inlet mock-up was performed by using nitrogen gas at room temperature in order to confirm uniform flow distribution and pressure drop characteristic. These tests have validated the helium inlet design. Based on the validation, Japanese and European Union domestic agencies, which have responsibilities of the TF coil procurement, are preparing the helium inlet mock-up for a qualification test. (authors)

Progress in IFMIF Engineering Validation and Engineering Design Activities

International Nuclear Information System (INIS)

Heidinger, R.; Knaster, J.; Matsumoto, H.; Sugimoto, M.; Mosnier, A.; Arbeiter, F.; Baluc, N.; Cara, P.; Chel, S.; Facco, A.; Favuzza, P.; Heinzel, V.; Ibarra, A.; Massaut, V.; Micciche, G.; Nitti, F.S.; Theile, J.

2013-01-01

Highlights: ► The IFMIF/EVEDA project has entered into the crucial phase of concluding the Interim IFMIF Engineering Design Report. ► The IFMIF plant configuration has been established with the definition of five IFMIF facilities and of their interfaces. ► Three major prototypes of the IFMIF main systems have been designed and are being manufactured, commissioned and operated. -- Abstract: The International Fusion Materials Irradiation Facility (IFMIF) Engineering Design and Engineering Validation Activities (EVEDA) are being developed in a joint project in the framework of the Broader Approach (BA) Agreement between EU and Japan. This project has now entered into a crucial phase as the engineering design of IFMIF is now being formulated in a series of 3 subsequent phases for delivering an Interim IFMIF Engineering Design Report (IIEDR) by mid of 2013. Content of these phases is explained, including the plant configuration detailing the 5 IFMIF facilities and their systems. Together with the Engineering Design Activities, prototyping sub-projects are pursued in the Engineering Validation Activities which consist of the design, manufacturing and testing of the following prototypical systems: Linear IFMIF Prototype Accelerator (LIPAc), EVEDA Lithium Test Loop (ELTL), and High Flux Test Module (HFTM) with the prototypical helium cooling loop (HELOKA). Highlights are described from recent experiments in the Engineering Validation Activities

Researching on knowledge architecture of design by analysis based on ASME code

International Nuclear Information System (INIS)

Bao Shiyi; Zhou Yu; He Shuyan

2003-01-01

The quality of knowledge-based system's knowledge architecture is one of decisive factors of knowledge-based system's validity and rationality. For designing the ASME code knowledge based system, this paper presents a knowledge acquisition method which is extracting knowledge through document analysis consulted domain experts' knowledge. Then the paper describes knowledge architecture of design by analysis based on the related rules in ASME code. The knowledge of the knowledge architecture is divided into two categories: one is empirical knowledge, and another is ASME code knowledge. Applied as the basement of the knowledge architecture, a general procedural process of design by analysis that is met the engineering design requirements and designers' conventional mode is generalized and explained detailed in the paper. For the sake of improving inference efficiency and concurrent computation of KBS, a kind of knowledge Petri net (KPN) model is proposed and adopted in expressing the knowledge architecture. Furthermore, for validating and verifying of the empirical rules, five knowledge validation and verification theorems are given in the paper. Moreover the research production is applicable to design the knowledge architecture of ASME codes or other engineering standards. (author)

Spent Nuclear Fuel (SNF) Project Design Verification and Validation Process

International Nuclear Information System (INIS)

OLGUIN, L.J.

2000-01-01

This document provides a description of design verification and validation activities implemented by the Spent Nuclear Fuel (SNF) Project. During the execution of early design verification, a management assessment (Bergman, 1999) and external assessments on configuration management (Augustenburg, 1999) and testing (Loscoe, 2000) were conducted and identified potential uncertainties in the verification process. This led the SNF Chief Engineer to implement corrective actions to improve process and design products. This included Design Verification Reports (DVRs) for each subproject, validation assessments for testing, and verification of the safety function of systems and components identified in the Safety Equipment List to ensure that the design outputs were compliant with the SNF Technical Requirements. Although some activities are still in progress, the results of the DVR and associated validation assessments indicate that Project requirements for design verification are being effectively implemented. These results have been documented in subproject-specific technical documents (Table 2). Identified punch-list items are being dispositioned by the Project. As these remaining items are closed, the technical reports (Table 2) will be revised and reissued to document the results of this work

Advanced nuclear reactor safety design technology research in NPIC

International Nuclear Information System (INIS)

Yu, H.

2014-01-01

After the Fukushima accident happen, Nuclear Power Plants (NPPs) construction has been suspended in China for a time. Now the new regulatory rule has been proposed that the most advanced safety standard must be adopted for the new NPPs and practical elimination of large fission product release by design during the next five plans period. So the advanced reactor research is developing in China. NPIC is engaging on the ACP1000 and ACP100 (Small Module Reactor) design. The main design character will be introduced in this paper. The Passive Combined with Active (PCWA) design was adopted during the ACP1000 design to reduce the core damage frequency (CDF); the Cavity Injection System (CIS) is design to mitigation the consequence of the severe accident. Advance passive safety system was designed to ensure the long term residual heat removal during the Small Module Reactor (SMR). The SMR will be utilized to be the floating reactors, district heating reactor and so on. Besides, the Science and Technology on Reactor System Design Technology Laboratory (LRSDT) also engaged on the fundamental thermal-hydraulic characteristic research in support of the system validation. (author)

Somatic Sensitivity and Reflexivity as Validity Tools in Qualitative Research

Science.gov (United States)

Green, Jill

2015-01-01

Validity is a key concept in qualitative educational research. Yet, it is often not addressed in methodological writing about dance. This essay explores validity in a postmodern world of diverse approaches to scholarship, by looking at the changing face of validity in educational qualitative research and at how new understandings of the concept…

Against (Design Research

Directory of Open Access Journals (Sweden)

Ferdinand Indrajaya

2011-10-01

Full Text Available The content of this article is an attempt to show that the word research in traditional sense (within the Cartesian scheme is hostile to design activity. It will reduce the process of design into a merely fix mechanical process, burying the aspect of imagination, creativity, and more importantly proposing in it that is a crucial aspect to design. This imposition might indiscipline (in a formal academic sense design as a discipline in human sciences. In order to achieve this, the article is divided in three sections. The first section will discuss what scientific research is and what traditionally presupposed in it: objective, neutral, and a-historical; simply the disinterestedness of research. As for the second, epistemological concerns on traditional scientific research from two philosophers of science will be discussed: Thomas S. Kuhn and Paul K. Feyerabend. As for the third, the closing section, an attempt to delineate design and what designers do in comparison to scientists’ will be discussed. It is how design and designers are different in their manners with traditional science and scientist. 

Research and development issues for fast reactor structural design standard (FDS)

International Nuclear Information System (INIS)

Kasahara, Naoto; Ando, Masanori; Morishita, Masaki

2003-01-01

For realization of safe and economical fast reactor (FR) plants, Japan Nuclear Cycle Development Institute (JNC) and Japan Atomic Power Company (JAPC) are cooperating on 'Feasibility Study on Commercialized FR Cycle Systems'. To certify the design concepts and validate their structural integrity, the research and development of 'Fast Reactor Structural Design Standard (FDS)' is recognized as an essential theme. FDS considers general characteristics of FRs and design needs for their rationalization. Three main subjects were settled in research and development issues of FDS. One is rationalization of failure criteria' taking characteristic design conditions into account. Next is development of 'a guideline on inelastic analysis for design' in order to predict elastic plastic and creep behaviours of high temperature components. Furthermore, efforts are being made toward preparing a guideline on thermal loads modeling' for FR component design where thermal loads are dominant. (author)

Validation of structural design of JHR fuel element

International Nuclear Information System (INIS)

Brisson, S.; Miras, G.; Le Bourdonnec, L.; Lemoine, P.; Anselmet, M.C.; Marelle, V.

2010-01-01

The validation of the structural design of the Jules Horowitz Reactor fuel element was made by the Finite Element Method, starting from the Computer Aided Design. The JHR fuel element is a cylindrical assembly of three sectors composed of eight rolled fuel plates. A roll-swaging process is used to join the fuel plates to three aluminium stiffeners. The hydraulic gap between each plate is 1.95 mm. The JHR fuel assembly is fastened at both ends to the upper and lower endfittings by riveting. The main stresses are essentially thermal loads, imposed on the fuel zone of the plates. These thermal loads result from the nuclear heat flux (W/cm 2 ). The mechanical loads are mainly hydraulic thrust forces. The average coolant velocity is 15 m/s. Seismic effects are also studied. The fuel assembly is entirely modelled by thin shells. The model takes into account asymmetric thermal loads which often appear in Research Reactors. The mechanics of the fuel plates vary in function of the burn up. These mechanical properties are derived from the data sets used in the MAIA code, and the validity of the structure is demonstrable at throughout the life of the fuel. Results concerning displacement are compared to functional criteria, while results concerning stress are compared to RCC-MX criteria. The results of this analysis show that the mechanical and geometrical integrity of the JHR fuel elements is respected for Operating Categories 1 and 2. This paper presents the methodology of this demonstration for the results obtained. (author)

Flight critical system design guidelines and validation methods

Science.gov (United States)

Holt, H. M.; Lupton, A. O.; Holden, D. G.

1984-01-01

Efforts being expended at NASA-Langley to define a validation methodology, techniques for comparing advanced systems concepts, and design guidelines for characterizing fault tolerant digital avionics are described with an emphasis on the capabilities of AIRLAB, an environmentally controlled laboratory. AIRLAB has VAX 11/750 and 11/780 computers with an aggregate of 22 Mb memory and over 650 Mb storage, interconnected at 256 kbaud. An additional computer is programmed to emulate digital devices. Ongoing work is easily accessed at user stations by either chronological or key word indexing. The CARE III program aids in analyzing the capabilities of test systems to recover from faults. An additional code, the semi-Markov unreliability program (SURE) generates upper and lower reliability bounds. The AIRLAB facility is mainly dedicated to research on designs of digital flight-critical systems which must have acceptable reliability before incorporation into aircraft control systems. The digital systems would be too costly to submit to a full battery of flight tests and must be initially examined with the AIRLAB simulation capabilities.

Research by Design - a Research and Teaching Concept

DEFF Research Database (Denmark)

Hauberg, Jørgen; Tamke, Martin; Ramsgaard Thomsen, Mette

2012-01-01

Abstract. Interweaving research and design-based architectural education is an important effort in most architect schools. All good design is informed by some kind of research – research-based design. And all architect schools involve research in their teaching – research based education. Research...... by design. The paper asks how “the new” in architectural production emerges and aims to find similarities between the tradition of practice based proposals and theorisation, and our own research and teaching practice. Grounded in this practice the paper investigates how research by design contributes...... to the construction of knowledge and student’s learning outcomes through research led workshops. The paper presents research inquiries, results and methodologies of two parallel research workshops and discusses the format by which this research tool is developed. Keywords: Research by Design, practice-based research...

Population Health Metrics Research Consortium gold standard verbal autopsy validation study: design, implementation, and development of analysis datasets

Directory of Open Access Journals (Sweden)

Ohno Summer

2011-08-01

Full Text Available Abstract Background Verbal autopsy methods are critically important for evaluating the leading causes of death in populations without adequate vital registration systems. With a myriad of analytical and data collection approaches, it is essential to create a high quality validation dataset from different populations to evaluate comparative method performance and make recommendations for future verbal autopsy implementation. This study was undertaken to compile a set of strictly defined gold standard deaths for which verbal autopsies were collected to validate the accuracy of different methods of verbal autopsy cause of death assignment. Methods Data collection was implemented in six sites in four countries: Andhra Pradesh, India; Bohol, Philippines; Dar es Salaam, Tanzania; Mexico City, Mexico; Pemba Island, Tanzania; and Uttar Pradesh, India. The Population Health Metrics Research Consortium (PHMRC developed stringent diagnostic criteria including laboratory, pathology, and medical imaging findings to identify gold standard deaths in health facilities as well as an enhanced verbal autopsy instrument based on World Health Organization (WHO standards. A cause list was constructed based on the WHO Global Burden of Disease estimates of the leading causes of death, potential to identify unique signs and symptoms, and the likely existence of sufficient medical technology to ascertain gold standard cases. Blinded verbal autopsies were collected on all gold standard deaths. Results Over 12,000 verbal autopsies on deaths with gold standard diagnoses were collected (7,836 adults, 2,075 children, 1,629 neonates, and 1,002 stillbirths. Difficulties in finding sufficient cases to meet gold standard criteria as well as problems with misclassification for certain causes meant that the target list of causes for analysis was reduced to 34 for adults, 21 for children, and 10 for neonates, excluding stillbirths. To ensure strict independence for the validation of

TWO CRITERIA FOR GOOD MEASUREMENTS IN RESEARCH: VALIDITY AND RELIABILITY

Directory of Open Access Journals (Sweden)

Haradhan Kumar Mohajan

2017-12-01

Full Text Available Reliability and validity are two most important and fundamental features in the evaluation of any measurement instrument or toll for a good research. The purpose of this research is to discuss the validity and reliability of measurement instruments that are used in research. Validity concerns what an instrument measures, and how well it does so. Reliability concerns the faith that one can have in the data obtained from use of an instrument, that is, the degree to which any measuring tool controls for random error. An attempt has been taken here to review the reliability and validity, and threat to them in some details.

Towards programmatic design research

Directory of Open Access Journals (Sweden)

Jonas Löwgren

2013-12-01

Full Text Available The notion of design research entails research where design practice forms part of the knowledge production. Based on our characterization of the nature of design, we propose to conceptualize this kind of research as programmatic design research. Two ongoing PhD projects in interaction design are presented as examples of programmatic research processes, highlighting issues to do with the virtues and qualities of the processes, the interplay of optics and engagements in a hermeneutical dynamic, and the production of takeaways for the academic community.

Research by Design: Design-Based Research and the Higher Degree Research student

Science.gov (United States)

Kennedy-Clark, Shannon

2013-01-01

Design-based research lends itself to educational research as the aim of this approach is to develop and refine the design of artefacts, tools and curriculum and to advance existing theory or develop new theories that can support and lead to a deepened understanding of learning. This paper provides an overview of the potential benefits of using a…

Research Designs and Special Education Research: Different Designs Address Different Questions

Science.gov (United States)

Cook, Bryan G.; Cook, Lysandra

2016-01-01

The aim of this article is to provide practitioners and other nonresearchers a basic understanding of research designs to aid in appropriately interpreting and applying research findings in special education. Research design provides the blueprint for conducting a research study and shapes what kind of knowledge is generated by the study. We…

Design (research) practice

DEFF Research Database (Denmark)

Binder, Thomas; Brandt, Eva

2017-01-01

possibilities through experimentation (Brandt and Binder 2007). Likewise in relation to design research we have argued that “the possible is always contingent and though research may convincingly provide arguments for certain possibilities both search and arguments have to be guided by programs that set...... substantiate or challenge this view and the dialectic between program and probing is in our view central to any design practice” (Binder and Redström 2006: 4). Our suggestion is to see design research practices as fundamentally homologous to any other design practices both in terms of the way they are driven...

Assessing model-based reasoning using evidence-centered design a suite of research-based design patterns

CERN Document Server

Mislevy, Robert J; Riconscente, Michelle; Wise Rutstein, Daisy; Ziker, Cindy

2017-01-01

This Springer Brief provides theory, practical guidance, and support tools to help designers create complex, valid assessment tasks for hard-to-measure, yet crucial, science education standards. Understanding, exploring, and interacting with the world through models characterizes science in all its branches and at all levels of education. Model-based reasoning is central to science education and thus science assessment. Current interest in developing and using models has increased with the release of the Next Generation Science Standards, which identified this as one of the eight practices of science and engineering. However, the interactive, complex, and often technology-based tasks that are needed to assess model-based reasoning in its fullest forms are difficult to develop. Building on research in assessment, science education, and learning science, this Brief describes a suite of design patterns that can help assessment designers, researchers, and teachers create tasks for assessing aspects of model-based...

Design and validation of an observational instrument for technical and tactical actions in beach volleyball

Directory of Open Access Journals (Sweden)

José Manuel Palao

2015-06-01

Full Text Available Technical and tactical actions determine performance in beach volleyball. This research develops and tests an instrument to monitor and evaluate the manner of execution and efficacy of the actions in beach volleyball. The purpose of this paper was to design and validate an observational instrument to analyze technical and tactical actions in beach volleyball. The instrument collects information regarding: a information about the match (context, b information about game situations, c information about technical situations (serve, reception, set, attack, block, and court defense in relation to player execution, role, manner of execution, execution zone, and efficacy, and d information about the result of the play (win-lose and way point is obtained. Instrument design and validation was done in seven stages: a review of literature and consultation of experts; b pilot observation and data analysis; c expert review of instrument (qualitative and quantitative evaluation; d observer training test; e expert review of instrument (content validity; f measurement of the ability of the instrument to discriminate the result of the set; and g measurement of the ability of the instrument to differentiate between competition age groups. The results show that the instrument allows for obtaining objective and valid information about the players and team from offensive and defensive technical and tactical actions, as well as indirectly from physical actions. The instrument can be used, in its entirety or partially, for researching and coaching purposes.

Design Process-System and Methodology of Design Research

Science.gov (United States)

Bashier, Fathi

2017-10-01

Studies have recognized the failure of the traditional design approach both in practice and in the studio. They showed that design problems today are too complex for the traditional approach to cope with and reflected a new interest in a better quality design services in order to meet the challenges of our time. In the mid-1970s and early 1980s, there has been a significant shift in focus within the field of design research towards the aim of creating a ‘design discipline’. The problem, as will be discussed, is the lack of an integrated theory of design knowledge that can explicitly describe the design process in a coherent way. As a consequence, the traditional approach fails to operate systematically, in a disciplinary manner. Addressing this problem is the primary goal of the research study in the design process currently being conducted in the research-based master studio at Wollega University, Ethiopia. The research study seeks to make a contribution towards a disciplinary approach, through proper understanding the mechanism of knowledge development within design process systems. This is the task of the ‘theory of design knowledge’. In this article the research project is introduced, and a model of the design process-system is developed in the studio as a research plan and a tool of design research at the same time. Based on data drawn from students’ research projects, the theory of design knowledge is developed and empirically verified through the research project.

Experimental Design Research

DEFF Research Database (Denmark)

This book presents a new, multidisciplinary perspective on and paradigm for integrative experimental design research. It addresses various perspectives on methods, analysis and overall research approach, and how they can be synthesized to advance understanding of design. It explores the foundations...... of experimental approaches and their utility in this domain, and brings together analytical approaches to promote an integrated understanding. The book also investigates where these approaches lead to and how they link design research more fully with other disciplines (e.g. psychology, cognition, sociology......, computer science, management). Above all, the book emphasizes the integrative nature of design research in terms of the methods, theories, and units of study—from the individual to the organizational level. Although this approach offers many advantages, it has inherently led to a situation in current...

Improved Hypersonic Inlet Performance Using Validated Strut Compression Designs

Science.gov (United States)

Bulman, M. J.; Stout, P. W.; Fernandez, R.

1997-01-01

Aerojet is currently executing two Strutjet propulsion contracts: one a Rocket Based Combined Cycle (RBCC) engine for a NASA-Marshall Space Flight Center (MSFC) Advanced Reusable Transportation Technology (ARTT) program, the second a Dual Mode Ram/Scramjet engine for a USAF Wright Laboratories Storable Fuel Scramjet Flow Path Concepts program. The engines employed in both programs operate at supersonic and low hypersonic speeds and use inlets employing forebody external and sidewall compression. Aerojet has developed and validated a successful design methodology applicable to these inlet types. Design features include an integrated vehicle forebody, external side compression struts, strut sidewall and throat bleed, a throat shock trap, and variable geometry internal contraction. Computation Fluid Dynamic (CFD) predictions and test data show these inlets allow substantially increased flow turning angles over other designs. These increased flow turning angles allow shorter and lighter engines than current designs, which in turn enables higher performing vehicles with broad operating characteristics. This paper describes the designs of two different inlets evaluated by the NASA-MSFC and USAF programs, discusses the results of wind tunnel tests performed by NASA-Lewis Research Center, and provides correlations of test data with CFD predictions. Parameters of interest include low Mach number starting capability, start sensitivity as a function of back pressure at various contraction ratios, flow turning angles, strut and throat bleed effects, and pressure recovery at various Mach numbers.

Validity in qualitative research: Interview and the appearance of truth through dialogue

Directory of Open Access Journals (Sweden)

Marja Kuzmanić

2009-07-01

Full Text Available This paper addresses several issues related to validity in qualitative research and, more specifically, explores the ways in which validity has been discussed and applied in research with qualitative interviews. The central question is to what extent, if at all, traditional positivist validity criteria are applicable, but also relevant, for evaluation of research with qualitative interviewing. The qualitative interview has been chosen as the focal point of this paper because of its peculiarity in terms of the relationship between the interviewer and the interviewee or, in other words, the ways in which during an interview meaning and narrative are constructed through discourse between the participants. The importance of the relationship (with its characteristics between research participants (interviewer and interviewee for the outcome of a qualitative interview cannot be overemphasized and is as such of particular interest for the assessment of its validity. I introduce and summarize the main approaches to the study and establishment of validity and scrutinize their significance for the example of qualitative interviewing and research in particular. This paper shows the importance of considering research context (in this instance interview for any assessment of validity, if validity at all ought to assume the same role in qualitative and quantitative research. As alternatives to the positivist notion of validity concepts such as reflexivity, transparency and credibility throughout the research process are introduced and advocated.

Doppler Lidar System Design via Interdisciplinary Design Concept at NASA Langley Research Center - Part II

Science.gov (United States)

Crasner, Aaron I.; Scola,Salvatore; Beyon, Jeffrey Y.; Petway, Larry B.

2014-01-01

Optimized designs of the Navigation Doppler Lidar (NDL) instrument for Autonomous Landing Hazard Avoidance Technology (ALHAT) were accomplished via Interdisciplinary Design Concept (IDEC) at NASA Langley Research Center during the summer of 2013. Three branches in the Engineering Directorate and three students were involved in this joint task through the NASA Langley Aerospace Research Summer Scholars (LARSS) Program. The Laser Remote Sensing Branch (LRSB), Mechanical Systems Branch (MSB), and Structural and Thermal Systems Branch (STSB) were engaged to achieve optimal designs through iterative and interactive collaborative design processes. A preliminary design iteration was able to reduce the power consumption, mass, and footprint by removing redundant components and replacing inefficient components with more efficient ones. A second design iteration reduced volume and mass by replacing bulky components with excessive performance with smaller components custom-designed for the power system. Thermal modeling software was used to run steady state thermal analyses, which were used to both validate the designs and recommend further changes. Analyses were run on each redesign, as well as the original system. Thermal Desktop was used to run trade studies to account for uncertainty and assumptions about fan performance and boundary conditions. The studies suggested that, even if the assumptions were significantly wrong, the redesigned systems would remain within operating temperature limits.

Design-Based Research

DEFF Research Database (Denmark)

Gynther, Karsten; Christensen, Ove; Petersen, Trine Brun

2012-01-01

I denne artikel introduceres Design Based Research for første gang på dansk i et videnskabeligt tidsskrift. Artiklen præsenterer de grundlæggende antagelser, som ligger til grund for Design Based Research-traditionen, og artiklen diskuterer de principper, som ligger til grund for gennemførelse af...... et DBR-forskningsprojekt. Med udgangspunkt i forsknings- og udviklingsprojektet ELYK: E-læring, Yderområder og Klyngedannelse, præsenteres den innovationsmodel, som projektet har udviklet med udgangspunkt i Design Based Research traditionen. ELYKs DBR innovationsmodel har vist sig effektiv i forhold...

The design in the quali-quantitative research in the production engineering – epistemological issues

Directory of Open Access Journals (Sweden)

Leonardo Ensslin

2008-07-01

Full Text Available The present paper intends to present a proposition of design for qualitative research applied to production engineering which contemplates material and formal elements in the investigative process, concentrating the discussion on the epistemological basis of the scientific development in the internal and external criteria of validity of the qualitative research and in the formation of the researcher as a primary and strategic element of the production process of critical and valid knowledge in this area of knowledge. Firstly the controversy between Popper and Kuhn in relation to the scientism and scientific method is presented and then later presenting the construct of the authors about this. Then the qualitative and quantitative methods are characterized, justifying the need of the predominance of the qualitative approach in some areas of production engineering. The third section is about the research project, its characteristics, its formal and material elements, and the use of internal and external validation criteria in a disciplined way, the use of the qualitative research and the formation of the researcher. Key-words: Soft Operational Research; Quali-quantitative Research, Epistemology.

Applying Case-Based Method in Designing Self-Directed Online Instruction: A Formative Research Study

Science.gov (United States)

Luo, Heng; Koszalka, Tiffany A.; Arnone, Marilyn P.; Choi, Ikseon

2018-01-01

This study investigated the case-based method (CBM) instructional-design theory and its application in designing self-directed online instruction. The purpose of this study was to validate and refine the theory for a self-directed online instruction context. Guided by formative research methodology, this study first developed an online tutorial…

Teaching engineering design research

DEFF Research Database (Denmark)

Blessing, Lucienne; Andreasen, Mogens Myrup

2005-01-01

The importance og engineering design as an industrial activity, and the increasingly complex and dynamic context in which it takes place, has led to the wish to improve the effectiveness and efficiency of engineering design in practice as well as in education. Although attempts have been made...... to improve design for centuries, it was not until well in the second half of the 20th century that engineering design became a research topic (see pahl and Beitz (1996), Heymann (2004) for historical overviews). Engineering research, such as research into thermodynamics, mechanics and materials, has a much...... by PhD students. This has created the demand for a clear, efficient way of learning the crafmanship of doing design research, a demand which is in strong contrast to the state of design research in general. This article reflects the authors' efforts in running a summer school om engineering design...

Ethical Implications of Validity-vs.-Reliability Trade-Offs in Educational Research

Science.gov (United States)

Fendler, Lynn

2016-01-01

In educational research that calls itself empirical, the relationship between validity and reliability is that of trade-off: the stronger the bases for validity, the weaker the bases for reliability (and vice versa). Validity and reliability are widely regarded as basic criteria for evaluating research; however, there are ethical implications of…

Synthesizing Knowledge in Design Research

DEFF Research Database (Denmark)

Piirainen, Kalle A.

2016-01-01

The chapter discusses knowledge synthesis in design research, bringing together the perspectives of experimental design research, or Research in Design Context that is treated extensively elsewhere in this book, and Design Inclusive Research as well as Practice-based Design Research. Specific...... attention is paid to the question of how practice-based or problem-driven design research processes can be rigorous and yield contributions to knowledge. The main argument in this chapter is that a key to knowledge synthesis and scientific contribution is setting explicit design propositions...... that are instantiated within design artefacts, and evaluated rigorously. The chapter starts with a discussion of knowledge creation and synthesis within design research.Following this, the chapter moves on to focus on setting a methodological framework for deriving design propositions. Lastly the chapter elaborates...

The Value of Qualitative Methods in Social Validity Research

Science.gov (United States)

Leko, Melinda M.

2014-01-01

One quality indicator of intervention research is the extent to which the intervention has a high degree of social validity, or practicality. In this study, I drew on Wolf's framework for social validity and used qualitative methods to ascertain five middle schoolteachers' perceptions of the social validity of System 44®--a phonics-based reading…

Alternatives to animal testing: research, trends, validation, regulatory acceptance.

Science.gov (United States)

Huggins, Jane

2003-01-01

Current trends and issues in the development of alternatives to the use of animals in biomedical experimentation are discussed in this position paper. Eight topics are considered and include refinement of acute toxicity assays; eye corrosion/irritation alternatives; skin corrosion/irritation alternatives; contact sensitization alternatives; developmental/reproductive testing alternatives; genetic engineering (transgenic) assays; toxicogenomics; and validation of alternative methods. The discussion of refinement of acute toxicity assays is focused primarily on developments with regard to reduction of the number of animals used in the LD(50) assay. However, the substitution of humane endpoints such as clinical signs of toxicity for lethality in these assays is also evaluated. Alternative assays for eye corrosion/irritation as well as those for skin corrosion/irritation are described with particular attention paid to the outcomes, both successful and unsuccessful, of several validation efforts. Alternative assays for contact sensitization and developmental/reproductive toxicity are presented as examples of methods designed for the examination of interactions between toxins and somewhat more complex physiological systems. Moreover, genetic engineering and toxicogenomics are discussed with an eye toward the future of biological experimentation in general. The implications of gene manipulation for research animals, specifically, are also examined. Finally, validation methods are investigated as to their effectiveness, or lack thereof, and suggestions for their standardization and improvement, as well as implementation are reviewed.

Spacecraft early design validation using formal methods

International Nuclear Information System (INIS)

Bozzano, Marco; Cimatti, Alessandro; Katoen, Joost-Pieter; Katsaros, Panagiotis; Mokos, Konstantinos; Nguyen, Viet Yen; Noll, Thomas; Postma, Bart; Roveri, Marco

2014-01-01

The size and complexity of software in spacecraft is increasing exponentially, and this trend complicates its validation within the context of the overall spacecraft system. Current validation methods are labor-intensive as they rely on manual analysis, review and inspection. For future space missions, we developed – with challenging requirements from the European space industry – a novel modeling language and toolset for a (semi-)automated validation approach. Our modeling language is a dialect of AADL and enables engineers to express the system, the software, and their reliability aspects. The COMPASS toolset utilizes state-of-the-art model checking techniques, both qualitative and probabilistic, for the analysis of requirements related to functional correctness, safety, dependability and performance. Several pilot projects have been performed by industry, with two of them having focused on the system-level of a satellite platform in development. Our efforts resulted in a significant advancement of validating spacecraft designs from several perspectives, using a single integrated system model. The associated technology readiness level increased from level 1 (basic concepts and ideas) to early level 4 (laboratory-tested)

On framing the research question and choosing the appropriate research design.

Science.gov (United States)

Parfrey, Patrick S; Ravani, Pietro

2015-01-01

Clinical epidemiology is the science of human disease investigation with a focus on diagnosis, prognosis, and treatment. The generation of a reasonable question requires definition of patients, interventions, controls, and outcomes. The goal of research design is to minimize error, to ensure adequate samples, to measure input and output variables appropriately, to consider external and internal validities, to limit bias, and to address clinical as well as statistical relevance. The hierarchy of evidence for clinical decision-making places randomized controlled trials (RCT) or systematic review of good quality RCTs at the top of the evidence pyramid. Prognostic and etiologic questions are best addressed with longitudinal cohort studies.

Validation of Serious Games

Directory of Open Access Journals (Sweden)

Katinka van der Kooij

2015-09-01

Full Text Available The application of games for behavioral change has seen a surge in popularity but evidence on the efficacy of these games is contradictory. Anecdotal findings seem to confirm their motivational value whereas most quantitative findings from randomized controlled trials (RCT are negative or difficult to interpret. One cause for the contradictory evidence could be that the standard RCT validation methods are not sensitive to serious games’ effects. To be able to adapt validation methods to the properties of serious games we need a framework that can connect properties of serious game design to the factors that influence the quality of quantitative research outcomes. The Persuasive Game Design model [1] is particularly suitable for this aim as it encompasses the full circle from game design to behavioral change effects on the user. We therefore use this model to connect game design features, such as the gamification method and the intended transfer effect, to factors that determine the conclusion validity of an RCT. In this paper we will apply this model to develop guidelines for setting up validation methods for serious games. This way, we offer game designers and researchers handles on how to develop tailor-made validation methods.

Reflecting Contemporary Design Research

DEFF Research Database (Denmark)

Engholm, Ida

2017-01-01

In recent years, design research has been the object of growing attention in universities and academies throughout the world. The present paper addresses the heterogeneous character of design research and the current need for reflection on the various approaches and interests. For this purpose......, the paper follows two steps. First, it proposes a categorization of the field in the form of a position model. The paper’s underlying assumption is that design research as a discipline exists in many different forms that cannot necessarily be brought together under one common academic research tradition......; instead it is necessary to attempt to define the field in order to initiate discussions about what constitutes the various research bases for design. Second, the paper discusses the implication for future design research when it is an interdisciplinary field that involves many disciplines, mindsets...

Naturalistic Cognition: A Research Paradigm for Human-Centered Design

Directory of Open Access Journals (Sweden)

Peter Storkerson

2010-01-01

Full Text Available Naturalistic thinking and knowing, the tacit, experiential, and intuitive reasoning of everyday interaction, have long been regarded as inferior to formal reason and labeled primitive, fallible, subjective, superstitious, and in some cases ineffable. But, naturalistic thinking is more rational and definable than it appears. It is also relevant to design. Inquiry into the mechanisms of naturalistic thinking and knowledge can bring its resources into focus and enable designers to create better, human-centered designs for use in real-world settings. This article makes a case for the explicit, formal study of implicit, naturalistic thinking within the fields of design. It develops a framework for defining and studying naturalistic thinking and knowledge, for integrating them into design research and practice, and for developing a more integrated, consistent theory of knowledge in design. It will (a outline historical definitions of knowledge, attitudes toward formal and naturalistic thinking, and the difficulties presented by the co-presence of formal and naturalistic thinking in design, (b define and contrast formal and naturalistic thinking as two distinct human cognitive systems, (c demonstrate the importance of naturalistic cognition in formal thinking and real-world judgment, (d demonstrate methods for researching naturalistic thinking that can be of use in design, and (e briefly discuss the impact on design theory of admitting naturalistic thinking as valid, systematic, and knowable.

IAEA programme to support development and validation of advanced design and safety analysis codes

Energy Technology Data Exchange (ETDEWEB)

Choi, J., E-mail: J.H.Choi@iaea.org [International Atomic Energy Agency, Vienna (Austria)

2013-07-01

The International Atomic Energy Agency (IAEA) has been organized many international collaboration programs to support the development and validation of design and safety analysis computer codes for nuclear power plants. These programs are normally implemented with a frame of Coordinated Research Project (CRP) or International Collaborative Standard Problem (ICSP). This paper introduces CRPs and ICSPs currently being organized or recently completed by IAEA for this purpose. (author)

Reflections on Design-Based Research

DEFF Research Database (Denmark)

Ørngreen, Rikke

2015-01-01

Design-Based Research is an intervention method that researches educational design (products or processes) in real-life settings with the dual purpose of generating theories about the domain and develop the design iteratively. This paper is an integrative review with a personal ethnographic...... narrative that draws on Design-Based Research literature, and identifies and discusses elements from Interaction Design and Action Research that the Design-Based Research approach could apply, situating the research in online educational projects, where participants are distributed in time and space...

Empirical research through design

NARCIS (Netherlands)

Keyson, D.V.; Bruns, M.

2009-01-01

This paper describes the empirical research through design method (ERDM), which differs from current approaches to research through design by enforcing the need for the designer, after a series of pilot prototype based studies, to a-priori develop a number of testable interaction design hypothesis

Control group design: enhancing rigor in research of mind-body therapies for depression.

Science.gov (United States)

Kinser, Patricia Anne; Robins, Jo Lynne

2013-01-01

Although a growing body of research suggests that mind-body therapies may be appropriate to integrate into the treatment of depression, studies consistently lack methodological sophistication particularly in the area of control groups. In order to better understand the relationship between control group selection and methodological rigor, we provide a brief review of the literature on control group design in yoga and tai chi studies for depression, and we discuss challenges we have faced in the design of control groups for our recent clinical trials of these mind-body complementary therapies for women with depression. To address the multiple challenges of research about mind-body therapies, we suggest that researchers should consider 4 key questions: whether the study design matches the research question; whether the control group addresses performance, expectation, and detection bias; whether the control group is ethical, feasible, and attractive; and whether the control group is designed to adequately control for nonspecific intervention effects. Based on these questions, we provide specific recommendations about control group design with the goal of minimizing bias and maximizing validity in future research.

Design and validation of the Quantum Mechanics Conceptual Survey

Directory of Open Access Journals (Sweden)

S. B. McKagan

2010-11-01

Full Text Available The Quantum Mechanics Conceptual Survey (QMCS is a 12-question survey of students’ conceptual understanding of quantum mechanics. It is intended to be used to measure the relative effectiveness of different instructional methods in modern physics courses. In this paper, we describe the design and validation of the survey, a process that included observations of students, a review of previous literature and textbooks and syllabi, faculty and student interviews, and statistical analysis. We also discuss issues in the development of specific questions, which may be useful both for instructors who wish to use the QMCS in their classes and for researchers who wish to conduct further research of student understanding of quantum mechanics. The QMCS has been most thoroughly tested in, and is most appropriate for assessment of (as a posttest only, sophomore-level modern physics courses. We also describe testing with students in junior quantum courses and graduate quantum courses, from which we conclude that the QMCS may be appropriate for assessing junior quantum courses, but is not appropriate for assessing graduate courses. One surprising result of our faculty interviews is a lack of faculty consensus on what topics should be taught in modern physics, which has made designing a test that is valued by a majority of physics faculty more difficult than expected.

Single-case research design in pediatric psychology: considerations regarding data analysis.

Science.gov (United States)

Cohen, Lindsey L; Feinstein, Amanda; Masuda, Akihiko; Vowles, Kevin E

2014-03-01

Single-case research allows for an examination of behavior and can demonstrate the functional relation between intervention and outcome in pediatric psychology. This review highlights key assumptions, methodological and design considerations, and options for data analysis. Single-case methodology and guidelines are reviewed with an in-depth focus on visual and statistical analyses. Guidelines allow for the careful evaluation of design quality and visual analysis. A number of statistical techniques have been introduced to supplement visual analysis, but to date, there is no consensus on their recommended use in single-case research design. Single-case methodology is invaluable for advancing pediatric psychology science and practice, and guidelines have been introduced to enhance the consistency, validity, and reliability of these studies. Experts generally agree that visual inspection is the optimal method of analysis in single-case design; however, statistical approaches are becoming increasingly evaluated and used to augment data interpretation.

Validation of a fracture mechanics approach to nuclear transportation cask design through a drop test program

International Nuclear Information System (INIS)

Sorenson, K.B.

1986-01-01

Sandia National Laboratories (SNL), under contract to the Department of Energy, is conducting a research program to develop and validate a fracture mechanics approach to cask design. A series of drop tests of a transportation cask is planned for the summer of 1986 as the method for benchmarking and, thereby, validating the fracture mechanics approach. This paper presents the drop test plan and background leading to the development of the test plan including structural analyses, material characterization, and non-destructive evaluation (NDE) techniques necessary for defining the test plan properly

An overview of research designs relevant to nursing: Part 1: quantitative research designs

OpenAIRE

Sousa,Valmi D.; Driessnack,Martha; Mendes,Isabel Amélia Costa

2007-01-01

This three part series of articles provides a brief overview of relevant research designs in nursing. The first article in the series presents the most frequently used quantitative research designs. Strategies for non-experimental and experimental research designs used to generate and refine nursing knowledge are described. In addition, the importance of quantitative designs and the role they play in developing evidence-based practice are discussed. Nursing care needs to be determined by the ...

Validation of designing tools as part of nuclear pump development process

International Nuclear Information System (INIS)

Klemm, T.; Sehr, F.; Spenner, P.; Fritz, J.

2010-01-01

Nuclear pumps are characterized by high safety standards, operational reliability as well as long life cycles. For the design process it is of common use to have a down scaled model pump to qualify operating data and simulate exceptional operating conditions. In case of modifications of the pump design compared to existing reactor coolant pumps a model pump is required to develop methods and tools to design the full scale pump. In the presented case it has a geometry scale of 1:2 regarding the full scale pump size. The experimental data of the model pump is basis for validation of methods and tools which are applied in the designing process of the full scale pump. In this paper the selection of qualified tools and the validation process is demonstrated exemplarily on a cooling circuit. The aim is to predict the resulting flow rate. Tools are chosen for different components depending on the benefit to effort ratio. For elementary flow phenomena such as fluid flow in straight pipes or gaps analytic or empirical laws can be used. For more complex flow situations numerical methods are utilized. Main focus is set on the validation process of the applied numerical flow simulation. In this case not only integral data should be compared, it is also necessary to validate local flow structure of numerical flow simulation to avoid systematic errors in CFD Model generation. Due to complex design internal flow measurements are not possible. On that reason simple comparisons of similar flow test cases are used. Results of this study show, that the flow simulation data closely match measured integral pump and test case data. With this validation it is now possible to qualify CFD simulations as a design tool for the full scale pump in similar cooling circuit. (authors)

Empirical Research In Engineering Design

DEFF Research Database (Denmark)

Ahmed, Saeema

2007-01-01

Increasingly engineering design research involves the use of empirical studies that are conducted within an industrial environment [Ahmed, 2001; Court 1995; Hales 1987]. Research into the use of information by designers or understanding how engineers build up experience are examples of research...... of research issues. This paper describes case studies of empirical research carried out within industry in engineering design focusing upon information, knowledge and experience in engineering design. The paper describes the research methods employed, their suitability for the particular research aims...

Seaworthy Quantum Key Distribution Design and Validation (SEAKEY)

Science.gov (United States)

2015-11-12

polarization control and the CV state and the LO state are separated at a polarizing beam splitter . The CV state is delayed relative to the LO state, and... splitter or loss imperfections. We have identified a number of risks associated with implementing this design . The two most critical risks are: • The...Contractor Address: 10 Moulton Street, Cambridge, MA 02138 Title of the Project: Seaworthy Quantum Key Distribution Design and Validation (SEAKEY

Development and Validation of a Rubric for Diagnosing Students’ Experimental Design Knowledge and Difficulties

Science.gov (United States)

Dasgupta, Annwesa P.; Anderson, Trevor R.

2014-01-01

It is essential to teach students about experimental design, as this facilitates their deeper understanding of how most biological knowledge was generated and gives them tools to perform their own investigations. Despite the importance of this area, surprisingly little is known about what students actually learn from designing biological experiments. In this paper, we describe a rubric for experimental design (RED) that can be used to measure knowledge of and diagnose difficulties with experimental design. The development and validation of the RED was informed by a literature review and empirical analysis of undergraduate biology students’ responses to three published assessments. Five areas of difficulty with experimental design were identified: the variable properties of an experimental subject; the manipulated variables; measurement of outcomes; accounting for variability; and the scope of inference appropriate for experimental findings. Our findings revealed that some difficulties, documented some 50 yr ago, still exist among our undergraduate students, while others remain poorly investigated. The RED shows great promise for diagnosing students’ experimental design knowledge in lecture settings, laboratory courses, research internships, and course-based undergraduate research experiences. It also shows potential for guiding the development and selection of assessment and instructional activities that foster experimental design. PMID:26086658

Design Research as a Mechanism for Consultants to Facilitate and Evaluate Educational Innovations

Science.gov (United States)

Castillo, Jose M.; Dorman, Clark; Gaunt, Brian; Hardcastle, Beth; Justice, Kelly; March, Amanda L.

2016-01-01

Schools across the nation are implementing innovative practices; however, questions remain regarding how to facilitate quality implementation. Research designs that emphasize high degrees of control over independent variables result in findings with internal validity, but that may not generalize to complex, dynamic educational systems. The purpose…

Developing theory-driven design research

DEFF Research Database (Denmark)

Cash, Philip J.

2018-01-01

Design research is increasingly weak in comparison with other fields; without action to increase scientific, theoretical, and methodological rigour there is a real possibility of the field being superseded and becoming obsolete through lack of impact. The aim of this paper is to show how design r....... I identify key learning indicating future directions for theory-driven design research. I conclude by providing some concrete recommendations for the field of design research and individual design researchers....

What Is This Thing Called "Design" in Design Research and Instructional Design

Science.gov (United States)

Cronje, Johannes

2013-01-01

This paper will consider the phenomenon of design research. It will then consider four research positions in social science research. The paper will show how the design perspectives map onto the research paradigms and how by rotating through these paradigms, a design research cycle is formed. Finally, the paper will discuss four research questions…

Constructive Synergy in Design Science Research: A Comparative Analysis of Design Science Research and the Constructive Research Approach

DEFF Research Database (Denmark)

Piirainen, Kalle; Gonzalez, Rafael A.

2014-01-01

Information systems research is focused on creating knowledge which can be applied in organizations. Design science research, which specifically aims at applying existing knowledge to solve interesting and relevant business problems, has been steadily gaining support in information systems research....... However, design science research is not the only design-oriented research framework available. Accordingly, this raises the question of whether there is something to learn between the different approaches. This paper contributes to answering this question by comparing design science research...... with the constructive research approach. The conclusion is that the two approaches are similar and compatible, save for details in practical requirements and partly underlying philosophical assumptions. The main finding that arises from the comparison is, however, that there is a potential problem in claiming knowledge...

Constructive Synergy in Design Science Research: A Comparative Analysis of Design Science Research and the Constructive Research Approach

DEFF Research Database (Denmark)

Piirainen, Kalle; Gonzalez, Rafael A.

2014-01-01

with the constructive research approach. The conclusion is that the two approaches are similar and compatible, save for details in practical requirements and partly underlying philosophical assumptions. The main finding that arises from the comparison is, however, that there is a potential problem in claiming knowledge......Information systems research is focused on creating knowledge which can be applied in organizations. Design science research, which specifically aims at applying existing knowledge to solve interesting and relevant business problems, has been steadily gaining support in information systems research....... However, design science research is not the only design-oriented research framework available. Accordingly, this raises the question of whether there is something to learn between the different approaches. This paper contributes to answering this question by comparing design science research...

Participatory design based research

DEFF Research Database (Denmark)

Dau, Susanne; Bach Jensen, Louise; Falk, Lars

This poster reveal how participatory design based research by the use of a CoED inspired creative process can be used for designing solutions to problems regarding students study activities outside campus.......This poster reveal how participatory design based research by the use of a CoED inspired creative process can be used for designing solutions to problems regarding students study activities outside campus....

Design and validation of advanced driver assistance systems

NARCIS (Netherlands)

Gietelink, O.J.

2007-01-01

This thesis presents new tools and methods for the design and validation of advanced driver assistance systems (ADASs). ADASs aim to improve driving comfort and traffic safety by assisting the driver in recognizing and reacting to potentially dangerous traffic situations. A major challenge in

Making the Case for Practice-Based Research and the Imperative Role of Design Practitioners.

Science.gov (United States)

Freihoefer, Kara; Zborowsky, Terri

2017-04-01

The purpose of this article is to justify the need for evidence-based design (EBD) in a research-based architecture and design practice. This article examines the current state of practice-based research (PBR), supports the need for EBD, illustrates PBR methods that can be applied to design work, and explores how findings can be used as a decision-making tool during design and as a validation tool during postoccupancy. As a result, design professions' body of knowledge will advance and practitioners will be better informed to protect the health, safety, and welfare of the society. Furthermore, characteristics of Friedman's progressive research program are used as a framework to examine the current state of PBR in design practice. A modified EBD approach is proposed and showcased with a case study of a renovated inpatient unit. The modified approach demonstrates how a highly integrated project team, especially the role of design practitioners, contributed to the success of utilizing baseline findings and evidence in decision-making throughout the design process. Lastly, recommendations and resources for learning research concepts are provided for practitioners. It is the role of practitioners to pave the way for the next generation of design professionals, as the request and expectation for research become more prevalent in design practice.

Quantification of construction waste prevented by BIM-based design validation: Case studies in South Korea.

Science.gov (United States)

Won, Jongsung; Cheng, Jack C P; Lee, Ghang

2016-03-01

Waste generated in construction and demolition processes comprised around 50% of the solid waste in South Korea in 2013. Many cases show that design validation based on building information modeling (BIM) is an effective means to reduce the amount of construction waste since construction waste is mainly generated due to improper design and unexpected changes in the design and construction phases. However, the amount of construction waste that could be avoided by adopting BIM-based design validation has been unknown. This paper aims to estimate the amount of construction waste prevented by a BIM-based design validation process based on the amount of construction waste that might be generated due to design errors. Two project cases in South Korea were studied in this paper, with 381 and 136 design errors detected, respectively during the BIM-based design validation. Each design error was categorized according to its cause and the likelihood of detection before construction. The case studies show that BIM-based design validation could prevent 4.3-15.2% of construction waste that might have been generated without using BIM. Copyright © 2015 Elsevier Ltd. All rights reserved.

Psychometric validation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Endometrial Cancer Module (EORTC QLQ-EN24)

DEFF Research Database (Denmark)

Greimel, Elfriede; Nordin, Andy; Lanceley, Anne

2011-01-01

A validation study was conducted to evaluate the psychometric properties of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Endometrial Cancer Module (EORTC QLQ-EN24). This module was designed to assess disease and treatment specific aspects of...... of the quality of life (QoL) of patients with endometrial cancer.......A validation study was conducted to evaluate the psychometric properties of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Endometrial Cancer Module (EORTC QLQ-EN24). This module was designed to assess disease and treatment specific aspects...

Strategies to design clinical studies to identify predictive biomarkers in cancer research.

Science.gov (United States)

Perez-Gracia, Jose Luis; Sanmamed, Miguel F; Bosch, Ana; Patiño-Garcia, Ana; Schalper, Kurt A; Segura, Victor; Bellmunt, Joaquim; Tabernero, Josep; Sweeney, Christopher J; Choueiri, Toni K; Martín, Miguel; Fusco, Juan Pablo; Rodriguez-Ruiz, Maria Esperanza; Calvo, Alfonso; Prior, Celia; Paz-Ares, Luis; Pio, Ruben; Gonzalez-Billalabeitia, Enrique; Gonzalez Hernandez, Alvaro; Páez, David; Piulats, Jose María; Gurpide, Alfonso; Andueza, Mapi; de Velasco, Guillermo; Pazo, Roberto; Grande, Enrique; Nicolas, Pilar; Abad-Santos, Francisco; Garcia-Donas, Jesus; Castellano, Daniel; Pajares, María J; Suarez, Cristina; Colomer, Ramon; Montuenga, Luis M; Melero, Ignacio

2017-02-01

The discovery of reliable biomarkers to predict efficacy and toxicity of anticancer drugs remains one of the key challenges in cancer research. Despite its relevance, no efficient study designs to identify promising candidate biomarkers have been established. This has led to the proliferation of a myriad of exploratory studies using dissimilar strategies, most of which fail to identify any promising targets and are seldom validated. The lack of a proper methodology also determines that many anti-cancer drugs are developed below their potential, due to failure to identify predictive biomarkers. While some drugs will be systematically administered to many patients who will not benefit from them, leading to unnecessary toxicities and costs, others will never reach registration due to our inability to identify the specific patient population in which they are active. Despite these drawbacks, a limited number of outstanding predictive biomarkers have been successfully identified and validated, and have changed the standard practice of oncology. In this manuscript, a multidisciplinary panel reviews how those key biomarkers were identified and, based on those experiences, proposes a methodological framework-the DESIGN guidelines-to standardize the clinical design of biomarker identification studies and to develop future research in this pivotal field. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

On the utility of within-participant research design when working with patients with neurocognitive disorders.

Science.gov (United States)

Steingrimsdottir, Hanna Steinunn; Arntzen, Erik

2015-01-01

Within-participant research designs are frequently used within the field of behavior analysis to document changes in behavior before, during, and after treatment. The purpose of the present article is to show the utility of within-participant research designs when working with older adults with neurocognitive disorders. The reason for advocating for these types of experimental designs is that they provide valid information about whether the changes that are observed in the dependent variable are caused by manipulations of the independent variable, or whether the change may be due to other variables. We provide examples from published papers where within-participant research design has been used with patients with neurocognitive disorders. The examples vary somewhat, demonstrating possible applications. It is our suggestion that the within-participant research design may be used more often with the targeted client group than is documented in the literature at the current date.

DTU-ESA millimeter-wave validation standard antenna – requirements and design

DEFF Research Database (Denmark)

Pivnenko, Sergey; Kim, Oleksiy S.; Breinbjerg, Olav

2014-01-01

from a validation campaign is achieved when a dedicated Validation Standard (VAST) antenna specifically designed for this purpose is available. The driving requirements to VAST antennas are their mechanical stability with respect to any orientation of the antenna in the gravity field and thermal...... are briefly reviewed and the baseline design is described. The emphasis is given to definition of the requirements for the mechanical and thermal stability of the antenna, which satisfy the stringent stability requirement for the mm-VAST electrical characteristics....

Initial verification and validation of RAZORBACK - A research reactor transient analysis code

Energy Technology Data Exchange (ETDEWEB)

Talley, Darren G. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

2015-09-01

This report describes the work and results of the initial verification and validation (V&V) of the beta release of the Razorback code. Razorback is a computer code designed to simulate the operation of a research reactor (such as the Annular Core Research Reactor (ACRR)) by a coupled numerical solution of the point reactor kinetics equations, the energy conservation equation for fuel element heat transfer, and the mass, momentum, and energy conservation equations for the water cooling of the fuel elements. This initial V&V effort was intended to confirm that the code work to-date shows good agreement between simulation and actual ACRR operations, indicating that the subsequent V&V effort for the official release of the code will be successful.

Design and Validation of Affective Warning Pictorial on Cigarette Labels

Directory of Open Access Journals (Sweden)

Chanduen Pat-Arin

2016-01-01

Full Text Available The purpose of present study were to design and validate affective warning pictorials for cigarette label in Thailand. Brainstorming and survey techniques were used to collect the idea of possible warning pictorials. All ideas were grouped for finding candidated pictorials. Then, primary sixty warning pictorials were collected and equally classified into three affective warning pictorial groups as positive, neutral, and negative. Sixty Thai male engineering students participated in affective validation of warning pictorials using SAM rating. The International Affective Picture System (IAPS was used to manipulate the affective state of participants to neutral affective state before the experiments. The results revealed that all affective warning pictorials were successfully evoked target affective states on participants. After refining, thirty affective warning pictorials were provided as positive, neutral, and negative affective warning pictorials for using on cigarette labels. Implications on the affective warning pictorials design and validation.

Measuring Children’s Perceptions of Robots’ Social Competence : Design and Validation

NARCIS (Netherlands)

Davison, Daniel Patrick; Charisi, Vasiliki; Wijnen, Frances Martine; Reidsma, Dennis; Evers, Vanessa; Kheddar, Abderrahmane; Yoshida, Eiichi; Ge, Shuzhi Sam; Suzuki, Kenji; Cabibihan, John-John; Eyssel, Friederike; He, Hongsheng

2017-01-01

This paper presents the design and validation of a measurement instrument for children’s perceptions of robots’ social competence. The need for a standardized validated instrument has emerged as a requisite for meta-analyses and comparisons among various studies in the field of child-robot

Low Noise Research Fan Stage Design

Science.gov (United States)

Hobbs, David E.; Neubert, Robert J.; Malmborg, Eric W.; Philbrick, Daniel H.; Spear, David A.

1995-01-01

This report describes the design of a Low Noise ADP Research Fan stage. The fan is a variable pitch design which is designed at the cruise pitch condition. Relative to the cruise setting, the blade is closed at takeoff and opened for reverse thrust operation. The fan stage is a split flow design with fan exit guide vanes and core stators. This fan stage design was combined with a nacelle and engine core duct to form a powered fan/nacelle, subscale model. This model is intended for use in aerodynamic performance, acoustic and structural testing in a wind tunnel. The model has a 22-inch outer fan diameter and a hub-to-top ratio of 0.426 which permits the use of existing NASA fan and cowl force balance designs and rig drive system. The design parameters were selected to permit valid acoustic and aerodynamic comparisons with the PW 17-inch rig previously tested under NASA contract. The fan stage design is described in detail. The results of the design axisymmetric analysis at aerodynamic design condition are included. The structural analysis of the fan rotor and attachment is described including the material selections and stress analysis. The blade and attachment are predicted to have adequate low cycle fatigue life, and an acceptable operating range without resonant stress or flutter. The stage was acoustically designed with airfoil counts in the fan exit guide vane and core stator to minimize noise. A fan-FEGV tone analysis developed separately under NASA contract was used to determine these airfoil counts. The fan stage design was matched to a nacelle design to form a fan/nacelle model for wind tunnel testing. The nacelle design was developed under a separate NASA contract. The nacelle was designed with an axisymmetric inlet, cowl and nozzle for convenience in testing and fabrication. Aerodynamic analysis of the nacelle confirmed the required performance at various aircraft operating conditions.

Investigating Design Research Landscapes through Exhibition

DEFF Research Database (Denmark)

Jönsson, Li; Hansen, Flemming Tvede; Mäkelä, Maarit

2013-01-01

What characterizes a design research exhibition compared to a traditional design and art exhibition? How do you show the very materialities of the design experiments as a means for communicating knowledge of research and of practice? How do you present, review and utilize such an exhibition......? With those questions in mind, the intention and challenge for the Nordes 2013 Design Research Exhibition was to expand on current notions of staging research enquires in design research conference contexts. Artefacts, installations, performances, and other materialities that relate to the theme...... of the conference - Experiments in Design Research – were displayed as tools to express and communicate different design research enquires. Through this paper we will describe the Nordes exhibition as a specific case that renders questions visible in relation to how to utilize a design research exhibition...

Safety research needs for Russian-designed reactors. Requirements situation

International Nuclear Information System (INIS)

Brown, R. Allan; Holmstrom, Heikki; Reocreux, Michel; Schulz, Helmut; Liesch, Klaus; Santarossa, Giampiero; Hayamizu, Yoshitaka; Asmolov, Vladimir; Bolshov, Leonid; Strizhov, Valerii; Bougaenko, Sergei; Nikitin, Yuri N.; Proklov, Vladimir; Potapov, Alexandre; Kinnersly, Stephen R.; Voronin, Leonid M.; Honekamp, John R.; Frescura, Gianni M.; Maki, Nobuo; Reig, Javier; ); Bekjord, Eric S.; Rosinger, Herbert E.

1998-01-01

In June 1995, an OECD Support Group was set up to perform a broad study of the safety research needs of Russian-designed reactors. The emphasis of the study is on the VVER-type reactors in part because of the larger base of knowledge within the NEA Member countries related to LWRs. For the RBMKs, the study does not make the judgement that such reactors can be brought to acceptable levels of safety but focuses on near term efforts that can contribute to reducing the risk to the public. The need for the safety research must be evaluated in context of the lifetime of the reactors. The principal outcome of the work of the Support Group is the identification of a number of research topics which the members believe should receive priority attention over the next several years if risk levels are to be reduced and public safety enhanced. These appear in the Conclusions and Recommendations section of the report, and are the following: - The most important near-term need for VVER and RBMK safety research is to establish a sound technical basis for the emergency operating procedures used by the plant staff to prevent or halt the progression of accidents (i.e., Accident Management) and for plant safety improvements. - Co-operation of Western and Eastern experts should help to avoid East-West know-how gaps in the future, as safety technology continues to improve. - Safety research in Eastern countries will make an important contribution to public safety as it has in OECD countries. - RBMK safety research, including verification of codes, starts from a smaller base of experience than VVER, and is at an earlier stage of development. Technical Conclusions: - Research to improve human performance and operational safety of VVER and RBMK plants is extremely important. - VVER thermal-hydraulic and reactor physics research should focus on full validation of codes to VVER-specific features, and on extension of experimental data base. - Methods of assessing VVER pressure boundary

Research design: the methodology for interdisciplinary research framework.

Science.gov (United States)

Tobi, Hilde; Kampen, Jarl K

2018-01-01

Many of today's global scientific challenges require the joint involvement of researchers from different disciplinary backgrounds (social sciences, environmental sciences, climatology, medicine, etc.). Such interdisciplinary research teams face many challenges resulting from differences in training and scientific culture. Interdisciplinary education programs are required to train truly interdisciplinary scientists with respect to the critical factor skills and competences. For that purpose this paper presents the Methodology for Interdisciplinary Research (MIR) framework. The MIR framework was developed to help cross disciplinary borders, especially those between the natural sciences and the social sciences. The framework has been specifically constructed to facilitate the design of interdisciplinary scientific research, and can be applied in an educational program, as a reference for monitoring the phases of interdisciplinary research, and as a tool to design such research in a process approach. It is suitable for research projects of different sizes and levels of complexity, and it allows for a range of methods' combinations (case study, mixed methods, etc.). The different phases of designing interdisciplinary research in the MIR framework are described and illustrated by real-life applications in teaching and research. We further discuss the framework's utility in research design in landscape architecture, mixed methods research, and provide an outlook to the framework's potential in inclusive interdisciplinary research, and last but not least, research integrity.

The Design Researcher in Quandary

DEFF Research Database (Denmark)

Kinch, Sofie; Fogtman, Majken Hillerup

2011-01-01

In the field of practice-based research we articulate the dilemma that emerges as the creative designer embraces the role of being an interaction design researcher. We exemplify the dilemma in a specific design case originating from a PhD project. In this case, we use sketching to illustrate how...... the design researcher embodies the creative designer at all times. We show how the dilemma becomes tangible in the conversation with the material when having to manage a set of design constraints, concerns and sensibilities. We acknowledge that when taking on both roles at the same time there are two...

Reflections on Design Methodology Research

DEFF Research Database (Denmark)

2011-01-01

We shall reflect on the results of Design Methodology research and their impact on design practice. In the past 50 years the number of researchers in the field has expanded enormously – as has the number of publications. During the same period design practice and its products have changed...... and produced are also now far more complex and distributed, putting designers under ever increasing pressure. We shall address the question: Are the results of Design Methodology research appropriate and are they delivering the expected results in design practice? In our attempt to answer this question we...

Development and validation of a questionnaire designed to measure foot-health status.

Science.gov (United States)

Bennett, P J; Patterson, C; Wearing, S; Baglioni, T

1998-09-01

The aim of this study was to apply the principles of content, criterion, and construct validation to a new questionnaire specifically designed to measure foot-health status. One hundred eleven subjects completed two different questionnaires designed to measure foot health (the new Foot Health Status Questionnaire and the previously validated Foot Function Index) and underwent a clinical examination in order to provide data for a second-order confirmatory factor analysis. Presented herein is a psychometrically evaluated questionnaire that contains 13 items covering foot pain, foot function, footwear, and general foot health. The tool demonstrates a high degree of content, criterion, and construct validity and test-retest reliability.

De novo peptide design and experimental validation of histone methyltransferase inhibitors.

Directory of Open Access Journals (Sweden)

James Smadbeck

Full Text Available Histones are small proteins critical to the efficient packaging of DNA in the nucleus. DNA–protein complexes, known as nucleosomes, are formed when the DNA winds itself around the surface of the histones. The methylation of histone residues by enhancer of zeste homolog 2 (EZH2 maintains gene repression over successive cell generations. Overexpression of EZH2 can silence important tumor suppressor genes leading to increased invasiveness of many types of cancers. This makes the inhibition of EZH2 an important target in the development of cancer therapeutics. We employed a three-stage computational de novo peptide design method to design inhibitory peptides of EZH2. The method consists of a sequence selection stage and two validation stages for fold specificity and approximate binding affinity. The sequence selection stage consists of an integer linear optimization model that was solved to produce a rank-ordered list of amino acid sequences with increased stability in the bound peptide-EZH2 structure. These sequences were validated through the calculation of the fold specificity and approximate binding affinity of the designed peptides. Here we report the discovery of novel EZH2 inhibitory peptides using the de novo peptide design method. The computationally discovered peptides were experimentally validated in vitro using dose titrations and mechanism of action enzymatic assays. The peptide with the highest in vitro response, SQ037, was validated in nucleo using quantitative mass spectrometry-based proteomics. This peptide had an IC50 of 13.5 mM, demonstrated greater potency as an inhibitor when compared to the native and K27A mutant control peptides, and demonstrated competitive inhibition versus the peptide substrate. Additionally, this peptide demonstrated high specificity to the EZH2 target in comparison to other histone methyltransferases. The validated peptides are the first computationally designed peptides that directly inhibit EZH2

De novo peptide design and experimental validation of histone methyltransferase inhibitors.

Directory of Open Access Journals (Sweden)

James Smadbeck

Full Text Available Histones are small proteins critical to the efficient packaging of DNA in the nucleus. DNA-protein complexes, known as nucleosomes, are formed when the DNA winds itself around the surface of the histones. The methylation of histone residues by enhancer of zeste homolog 2 (EZH2 maintains gene repression over successive cell generations. Overexpression of EZH2 can silence important tumor suppressor genes leading to increased invasiveness of many types of cancers. This makes the inhibition of EZH2 an important target in the development of cancer therapeutics. We employed a three-stage computational de novo peptide design method to design inhibitory peptides of EZH2. The method consists of a sequence selection stage and two validation stages for fold specificity and approximate binding affinity. The sequence selection stage consists of an integer linear optimization model that was solved to produce a rank-ordered list of amino acid sequences with increased stability in the bound peptide-EZH2 structure. These sequences were validated through the calculation of the fold specificity and approximate binding affinity of the designed peptides. Here we report the discovery of novel EZH2 inhibitory peptides using the de novo peptide design method. The computationally discovered peptides were experimentally validated in vitro using dose titrations and mechanism of action enzymatic assays. The peptide with the highest in vitro response, SQ037, was validated in nucleo using quantitative mass spectrometry-based proteomics. This peptide had an IC50 of 13.5 [Formula: see text]M, demonstrated greater potency as an inhibitor when compared to the native and K27A mutant control peptides, and demonstrated competitive inhibition versus the peptide substrate. Additionally, this peptide demonstrated high specificity to the EZH2 target in comparison to other histone methyltransferases. The validated peptides are the first computationally designed peptides that directly

Sharing Video Datasets in Design Research

DEFF Research Database (Denmark)

Christensen, Bo; Abildgaard, Sille Julie Jøhnk

2017-01-01

This paper examines how design researchers, design practitioners and design education can benefit from sharing a dataset. We present the Design Thinking Research Symposium 11 (DTRS11) as an exemplary project that implied sharing video data of design processes and design activity in natural settings...... with a large group of fellow academics from the international community of Design Thinking Research, for the purpose of facilitating research collaboration and communication within the field of Design and Design Thinking. This approach emphasizes the social and collaborative aspects of design research, where...... a multitude of appropriate perspectives and methods may be utilized in analyzing and discussing the singular dataset. The shared data is, from this perspective, understood as a design object in itself, which facilitates new ways of working, collaborating, studying, learning and educating within the expanding...

Dynamics of Research through Design

DEFF Research Database (Denmark)

Basballe, Ditte Amund; Halskov, Kim

2012-01-01

In this paper, we investigate Research through Design at a micro-level, by addressing the dynamic interplay of research and design as they unfold throughout a design process. As our principal case, we consider the design of a three-dimensional projection installation, a process that unfolded over...... a one-year period. We analyse material collected from 18 key events during the process, in order to identify the ongoing dynamics. Based on the analysis, we establish how the interplay evolves in a complex structure, where the design and research interests continuously couple, interweave, and decouple...

Dynamics of Research through Design

DEFF Research Database (Denmark)

Basballe, Ditte Amund; Halskov, Kim

2012-01-01

a one-year period. We analyse material collected from 18 key events during the process, in order to identify the ongoing dynamics. Based on the analysis, we establish how the interplay evolves in a complex structure, where the design and research interests continuously couple, interweave, and decouple......In this paper, we investigate Research through Design at a micro-level, by addressing the dynamic interplay of research and design as they unfold throughout a design process. As our principal case, we consider the design of a three-dimensional projection installation, a process that unfolded over...

Validity in Mixed Methods Research in Education: The Application of Habermas' Critical Theory

Science.gov (United States)

Long, Haiying

2017-01-01

Mixed methods approach has developed into the third methodological movement in educational research. Validity in mixed methods research as an important issue, however, has not been examined as extensively as that of quantitative and qualitative research. Additionally, the previous discussions of validity in mixed methods research focus on research…

The Square Curve Paradigm for Research in Alternative, Complementary, and Holistic Medicine: A Cost-Effective, Easy, and Scientifically Valid Design for Evidence-Based Medicine and Quality Improvement

Directory of Open Access Journals (Sweden)

Soren Ventegodt

2003-01-01

Full Text Available In this paper we present a new research paradigm for alternative, complementary, and holistic medicine — a low-cost, effective, and scientifically valid design for evidence-based medicine. Our aim is to find the simplest, cheapest, and most practical way to collect data of sufficient quality and validity to determine: (1 which kinds of treatment give a clinically relevant improvement to quality of life, health, and/or functionality; (2 which groups of patients can be aided by alternative, complementary, or holistic medicine; and (3 which therapists have the competence to achieve the clinically relevant improvements. Our solution to the problem is that a positive change in quality of life must be immediate to be taken as caused by an intervention. We define “immediate” as within 1 month of the intervention. If we can demonstrate a positive result with a group of chronic patients (20 or more patients who have had their disease or state of suffering for 1 year or more, who can be significantly helped within 1 month, and the situation is still improved 1 year after, we find it scientifically evidenced that this cure or intervention has helped the patients. We call this characteristic curve a “square curve”. If a global, generic, quality-of-life questionnaire like QOL5 or, even better, a QOL-Health-Ability questionnaire (a quality-of-life questionnaire combined with a self-evaluated health and ability to function questionnaire is administered to the patients before and after the intervention, it is possible to document the effect of an intervention to a cost of only a few thousand Euros/USD. A general acceptance of this new research design will solve the problem that there is not enough money in alternative, complementary, and holistic medicine to pay the normal cost of a biomedical Cochrane study. As financial problems must not hinder the vital research in nonbiomedical medicine, we ask the scientific community to accept this new research

Computational design and experimental validation of new thermal barrier systems

Energy Technology Data Exchange (ETDEWEB)

Guo, Shengmin [Louisiana State Univ., Baton Rouge, LA (United States)

2015-03-31

The focus of this project is on the development of a reliable and efficient ab initio based computational high temperature material design method which can be used to assist the Thermal Barrier Coating (TBC) bond-coat and top-coat design. Experimental evaluations on the new TBCs are conducted to confirm the new TBCs’ properties. Southern University is the subcontractor on this project with a focus on the computational simulation method development. We have performed ab initio density functional theory (DFT) method and molecular dynamics simulation on screening the top coats and bond coats for gas turbine thermal barrier coating design and validation applications. For experimental validations, our focus is on the hot corrosion performance of different TBC systems. For example, for one of the top coatings studied, we examined the thermal stability of TaZr_2.75O₈ and confirmed it’s hot corrosion performance.

Design and Validation of a Rubric to Assess the Use of American Psychological Association Style in Scientific Articles

Science.gov (United States)

Merma Molina, Gladys; Peña Alfaro, Hilda; Peña Alfaro González, Silvia Rosa

2017-01-01

In this study, the researchers will explore the process of designing and validating a rubric to evaluate the adaptation of scientific articles in the format of the "American Psychological Association" (APA). The rubric will evaluate certain aspects of the APA format that allow authors, editors, and evaluators to decide if the scientific…

Fashion Research at Design Schools

DEFF Research Database (Denmark)

Skjold, Else

2008-01-01

as a continuation of the way teaching in fashion design and research on fashion is perceived in the various cases. This of course implements the fact that there are very diverse perceptions on what fashion research is.  A main discussion therefore concerns current methodological diversities in fashion research......The report “Fashion Research at Design Schools” (2008), which was commissioned by Institute for Fashion and Textiles at Designskolen Kolding,  appoints the potentials and challenges in relation to the ongoing academization of design schools, with a specific focus on fashion research. The key...... research question is: “What kind of fashion design education is Designskolen Kolding aiming to offer in the future, what kind of skills will the students need in their future work place, the fashion industry, and can research work as a potential in this process?”   The study is based on qualitative...

Threats to the Internal Validity of Experimental and Quasi-Experimental Research in Healthcare.

Science.gov (United States)

Flannelly, Kevin J; Flannelly, Laura T; Jankowski, Katherine R B

2018-01-24

The article defines, describes, and discusses the seven threats to the internal validity of experiments discussed by Donald T. Campbell in his classic 1957 article: history, maturation, testing, instrument decay, statistical regression, selection, and mortality. These concepts are said to be threats to the internal validity of experiments because they pose alternate explanations for the apparent causal relationship between the independent variable and dependent variable of an experiment if they are not adequately controlled. A series of simple diagrams illustrate three pre-experimental designs and three true experimental designs discussed by Campbell in 1957 and several quasi-experimental designs described in his book written with Julian C. Stanley in 1966. The current article explains why each design controls for or fails to control for these seven threats to internal validity.

Design of controller for control rod of research reactors

International Nuclear Information System (INIS)

Abou-Zaid, R.M.F.M

2008-01-01

Designing and testing digital control system for any nuclear research reactor can be costly and time consuming. In this thesis, a rapid, low-cost proto typing and testing procedure for digital controller design is proposed using the concept of Hardware-In-The-Loop (HIL). Some of the control loop components are real hardware components and the others are simulated. First, the whole system is modeled and tested by Real-Time Simulation (RTS) using conventional simulation techniques such as MATLAB / SIMULINK. Second the Hardware-in-the-loop simulation is tested using Real-Time Windows Target in MATLAB and Visual C ++ . The control parts are included as hardware components which are the reactor control rod and its drivers. Three kinds of controllers are studied, Proportional-Derivative (PD), Proportional-Integral-Derivative (PID) and Fuzzy controller. An experimental setup for the hardware used in HIL concept for the control of the nuclear research reactor has been realized. Experimental results are obtained and compared with the simulation results. The experimental results indicate the validation of HIL method in this domain.

Design, construction and validation of the UST-1 modular stellarator

Energy Technology Data Exchange (ETDEWEB)

Queral, V., E-mail: vicentemanuel.queral@ciemat.es

2016-11-15

Highlights: • A small and simple low cost two period modular stellarator is reviewed. • It is defined as a monolithic circular surface torus with carved grooves. • The grooves are accurately mechanised by a new toroidal milling machine. • A very simple e-beam field mapping system has been built and utilized. - Abstract: Stellarator advancement is hindered, among others, by the requirement of geometric complexity at high accuracy and the still scarce universities and research centres following the stellarator line. In this framework, the objectives of the small UST-1 stellarator development were to: (i) explore and test the performance of one possible accurate construction method for stellarators (ii) encourage universities and small fusion research centres to build simple and economical stellarators (iii) educative purpose. Therefore, UST-1 was properly designed to be easily built by a milling machine working on toroidal coordinates, being the winding surface circular poloidally and toroidally. The coil frame is a sole monolithic toroidal thick surface equipped with grooves mechanised by the toroidal milling machine. Only one double pancake is wound in each groove so as to compress the conductor on the laterals of the groove in order to speed up and simplify the winding process. The physics design, the conceptual engineering design and the construction process of UST-1 is presented. The toroidal milling machine is described. The e-beam field line mapping experiments carried out to validate the resulting magnetic configuration are reported. The developed construction method has been proved for the small UST-1 stellarator. Small stellarators are valuable for quick tests of diagnostics, educative purposes, assessment of new confinement concepts, turbulence studies and other applications.

Design, construction and validation of the UST-1 modular stellarator

International Nuclear Information System (INIS)

Queral, V.

2016-01-01

Highlights: • A small and simple low cost two period modular stellarator is reviewed. • It is defined as a monolithic circular surface torus with carved grooves. • The grooves are accurately mechanised by a new toroidal milling machine. • A very simple e-beam field mapping system has been built and utilized. - Abstract: Stellarator advancement is hindered, among others, by the requirement of geometric complexity at high accuracy and the still scarce universities and research centres following the stellarator line. In this framework, the objectives of the small UST-1 stellarator development were to: (i) explore and test the performance of one possible accurate construction method for stellarators (ii) encourage universities and small fusion research centres to build simple and economical stellarators (iii) educative purpose. Therefore, UST-1 was properly designed to be easily built by a milling machine working on toroidal coordinates, being the winding surface circular poloidally and toroidally. The coil frame is a sole monolithic toroidal thick surface equipped with grooves mechanised by the toroidal milling machine. Only one double pancake is wound in each groove so as to compress the conductor on the laterals of the groove in order to speed up and simplify the winding process. The physics design, the conceptual engineering design and the construction process of UST-1 is presented. The toroidal milling machine is described. The e-beam field line mapping experiments carried out to validate the resulting magnetic configuration are reported. The developed construction method has been proved for the small UST-1 stellarator. Small stellarators are valuable for quick tests of diagnostics, educative purposes, assessment of new confinement concepts, turbulence studies and other applications.

Automated reasoning applications to design validation and sneak function analysis

International Nuclear Information System (INIS)

Stratton, R.C.

1984-01-01

Argonne National Laboratory (ANL) is actively involved in the LMFBR Man-Machine Integration (MMI) Safety Program. The objective of this program is to enhance the operational safety and reliability of fast-breeder reactors by optimum integration of men and machines through the application of human factors principles and control engineering to the design, operation, and the control environment. ANL is developing methods to apply automated reasoning and computerization in the validation and sneak function analysis process. This project provides the element definitions and relations necessary for an automated reasoner (AR) to reason about design validation and sneak function analysis. This project also provides a demonstration of this AR application on an Experimental Breeder Reactor-II (EBR-II) system, the Argonne Cooling System

Advanced Low-Noise Research Fan Stage Design

Science.gov (United States)

Neubert, Robert; Bock, Larry; Malmborg, Eric; Owen-Peer, William

1997-01-01

This report describes the design of the Advanced Low-Noise Research Fan stage. The fan is a variable pitch design, which is designed at the cruise pitch condition. Relative to the cruise setting, the blade is closed at takeoff and opened for reverse thrust operation. The fan stage is a split flow design with fan exit guide vanes (FEGVs) and core stators. The fan stage design is combined with a nacelle and engine core duct to form a powered fan/nacelle subscale model. This model is intended for use in combined aerodynamic, acoustic, and structural testing in a wind tunnel. The fan has an outer diameter of 22 in. and a hub-to-tip of 0.426 in., which allows the use of existing NASA fan and cowl force balance and rig drive systems. The design parameters were selected to permit valid acoustic and aerodynamic comparisons with the Pratt & Whitney (P&W) 17- and 22-in. rigs previously tested under NASA contract. The fan stage design is described in detail. The results of the design axisymmetric and Navier-Stokes aerodynamic analysis are presented at the critical design conditions. The structural analysis of the fan rotor and attachment is included. The blade and attachment are predicted to have adequate low-cycle fatigue life and an acceptable operating range without resonant stress or flutter. The stage was acoustically designed with airfoil counts in the FEGV and core stator to minimize noise. A fan/FEGV tone analysis developed separately under NASA contract was used to determine the optimum airfoil counts. The fan stage was matched to the existing nacelle, designed under the previous P&W low-noise contract, to form a fan/nacelle model for wind tunnel testing. It is an axisymmetric nacelle for convenience in testing and analysis. Previous testing confirmed that the nacelle performed as required at various aircraft operating conditions.

Rigor or Reliability and Validity in Qualitative Research: Perspectives, Strategies, Reconceptualization, and Recommendations.

Science.gov (United States)

Cypress, Brigitte S

Issues are still raised even now in the 21st century by the persistent concern with achieving rigor in qualitative research. There is also a continuing debate about the analogous terms reliability and validity in naturalistic inquiries as opposed to quantitative investigations. This article presents the concept of rigor in qualitative research using a phenomenological study as an exemplar to further illustrate the process. Elaborating on epistemological and theoretical conceptualizations by Lincoln and Guba, strategies congruent with qualitative perspective for ensuring validity to establish the credibility of the study are described. A synthesis of the historical development of validity criteria evident in the literature during the years is explored. Recommendations are made for use of the term rigor instead of trustworthiness and the reconceptualization and renewed use of the concept of reliability and validity in qualitative research, that strategies for ensuring rigor must be built into the qualitative research process rather than evaluated only after the inquiry, and that qualitative researchers and students alike must be proactive and take responsibility in ensuring the rigor of a research study. The insights garnered here will move novice researchers and doctoral students to a better conceptual grasp of the complexity of reliability and validity and its ramifications for qualitative inquiry.

Research design models: a new category

International Nuclear Information System (INIS)

Burgeson, D.A.

1983-01-01

This paper discusses the concept of a research design model and how it differs from an engineering design model. Essentially, the research design model draws on the methods, materials and processes of engineering design models but more emphasis is placed on conceptualization in 3-D. Typically, equipment and processes in research are unique. Often, there are competing concepts from which to decide. The approach which is evolving at Sandia National Laboratories mixes preliminary, engineering and research design on the same model

LATUX: An Iterative Workflow for Designing, Validating, and Deploying Learning Analytics Visualizations

Science.gov (United States)

Martinez-Maldonado, Roberto; Pardo, Abelardo; Mirriahi, Negin; Yacef, Kalina; Kay, Judy; Clayphan, Andrew

2015-01-01

Designing, validating, and deploying learning analytics tools for instructors or students is a challenge that requires techniques and methods from different disciplines, such as software engineering, human-computer interaction, computer graphics, educational design, and psychology. Whilst each has established its own design methodologies, we now…

Game Design as STS Research

Directory of Open Access Journals (Sweden)

Joseph Dumit

2017-09-01

Full Text Available Game design offers a powerful pedagogical paradigm for engaging students in thinking and researching sociotechnical systems. Using the example of designing a game around fracking, this paper describes how game design grapples with emergent dynamic processes, and how students are drawn into becoming STS researchers.

Challenges in Nordic Design Research

DEFF Research Database (Denmark)

Andreasen, Mogens Myrup

1996-01-01

Design research has not won a convincing reputation in industry. Nordic research being scattered and small in number of researchers should find its special strengths and focus on creating results, which are based on our peculiar conditions and background.......Design research has not won a convincing reputation in industry. Nordic research being scattered and small in number of researchers should find its special strengths and focus on creating results, which are based on our peculiar conditions and background....

Research by Design, Demarcation and Recoginition

NARCIS (Netherlands)

Doevendans, C.H.; Sap, H.A.; Langenhuizen, Anja; Ouwerkerk, Marieke van; Rosemann, Jurgen

2001-01-01

There is a strong tendency to see designing as a form of research; research by design. On the other hand it is stated that the urban design discipline has ceased to exist or does not develop anymore. Is this correct and can 'research by design' change this situation? These are the questions of

Validation of a new assessment tool for qualitative research articles

DEFF Research Database (Denmark)

Schou, Lone; Høstrup, Helle; Lyngsø, Elin

2012-01-01

schou l., høstrup h., lyngsø e.e., larsen s. & poulsen i. (2011) Validation of a new assessment tool for qualitative research articles. Journal of Advanced Nursing00(0), 000-000. doi: 10.1111/j.1365-2648.2011.05898.x ABSTRACT: Aim.  This paper presents the development and validation of a new...... assessment tool for qualitative research articles, which could assess trustworthiness of qualitative research articles as defined by Guba and at the same time aid clinicians in their assessment. Background.  There are more than 100 sets of proposals for quality criteria for qualitative research. However, we...... is the Danish acronym for Appraisal of Qualitative Studies. Phase 1 was to develop the tool based on a literature review and on consultation with qualitative researchers. Phase 2 was an inter-rater reliability test in which 40 health professionals participated. Phase 3 was an inter-rater reliability test among...

Validating the extract, transform, load process used to populate a large clinical research database.

Science.gov (United States)

Denney, Michael J; Long, Dustin M; Armistead, Matthew G; Anderson, Jamie L; Conway, Baqiyyah N

2016-10-01

Informaticians at any institution that are developing clinical research support infrastructure are tasked with populating research databases with data extracted and transformed from their institution's operational databases, such as electronic health records (EHRs). These data must be properly extracted from these source systems, transformed into a standard data structure, and then loaded into the data warehouse while maintaining the integrity of these data. We validated the correctness of the extract, load, and transform (ETL) process of the extracted data of West Virginia Clinical and Translational Science Institute's Integrated Data Repository, a clinical data warehouse that includes data extracted from two EHR systems. Four hundred ninety-eight observations were randomly selected from the integrated data repository and compared with the two source EHR systems. Of the 498 observations, there were 479 concordant and 19 discordant observations. The discordant observations fell into three general categories: a) design decision differences between the IDR and source EHRs, b) timing differences, and c) user interface settings. After resolving apparent discordances, our integrated data repository was found to be 100% accurate relative to its source EHR systems. Any institution that uses a clinical data warehouse that is developed based on extraction processes from operational databases, such as EHRs, employs some form of an ETL process. As secondary use of EHR data begins to transform the research landscape, the importance of the basic validation of the extracted EHR data cannot be underestimated and should start with the validation of the extraction process itself. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Design Science Research

DEFF Research Database (Denmark)

Pries-Heje, Jan; Venable, John; Baskerville, Richard L.

2017-01-01

This workshop is an applied tutorial, aimed at novice and experienced researchers who wish to learn more about Design Science Research (DSR) and/or to develop and progress their own DSR work. During the workshop, attendees will be introduced to various DSR concepts and current trends, to create...

Gifts to the Future: Design Reasoning, Design Research, and Critical Design Practitioners

Directory of Open Access Journals (Sweden)

Janet McDonnell

Full Text Available Set in the context of a particular orthodoxy about the history of design research over the last 50 years, this opinion piece selectively surveys some of the significant findings from research into what expert design reasoning entails. Using the conceit of a pool of knowledge—which has come about from many different design research agendas, using multiple methods, and with differing foci of attention—it indicates some of what we know about design reasoning as a phenomenon by taking three “scoops” from the pool. These scoops, respectively characterize design reasoning as navigating the swamp; having negative capability; and being concerned with framing. This material is then used to contrast expert design reasoning with salient features of some popular characterizations of design thinking. The contribution concludes with some comments on designer formation, centered on the necessity of proficiency in reflection implied by any goal to nurture critical design practitioners.

The Design Social: Framing social research methods for design postgraduates.

OpenAIRE

Evans, Martyn

2010-01-01

This paper discusses approaches for framing social research methods within postgraduate design curricula, details the responses of postgraduate design students to the possibilities presented by social research methods, and concludes with a case study of the adoption experiences of PhD students in design when engaging with social research methods. Analysis of semi-structured interviews is employed to draw out perceptions and experiences of design postgraduates when engaging with social researc...

Conceptualizing Essay Tests' Reliability and Validity: From Research to Theory

Science.gov (United States)

Badjadi, Nour El Imane

2013-01-01

The current paper on writing assessment surveys the literature on the reliability and validity of essay tests. The paper aims to examine the two concepts in relationship with essay testing as well as to provide a snapshot of the current understandings of the reliability and validity of essay tests as drawn in recent research studies. Bearing in…

Design of a multipurpose research reactor

International Nuclear Information System (INIS)

Sanchez Rios, A.A.

1990-01-01

The availability of a research reactor is essential in any endeavor to improve the execution of a nuclear programme, since it is a very versatile tool which can make a decisive contribution to a country's scientific and technological development. Because of their design, however, many existing research reactors are poorly adapted to certain uses. In some nuclear research centres, especially in the advanced countries, changes have been made in the original designs or new research prototypes have been designed for specific purposes. These modifications have proven very costly and therefore beyond the reach of developing countries. For this reason, what the research institutes in such countries need is a single sufficiently versatile nuclear plant capable of meeting the requirements of a nuclear research programme at a reasonable cost. This is precisely what a multipurpose reactor does. The Mexican National Nuclear Research Institute (ININ) plans to design and build a multipurpose research reactor capable at the same time of being used for the development of reactor design skills and for testing nuclear materials and fuels, for radioisotopes production, for nuclear power studies and basic scientific research, for specialized training, and so on. For this design work on the ININ Multipurpose Research Reactor, collaborative relations have been established with various international organizations possessing experience in nuclear reactor design: Atomehnergoeksport of the USSR: Atomic Energy of Canada Limited (AECL); General Atomics (GA) of the USA; and Japan Atomic Energy Research Institute

Design, validation, and reliability of survey to measure female athlete triad knowledge among coaches

Directory of Open Access Journals (Sweden)

Jillian E. Frideres

2015-06-01

Full Text Available The purpose of this study was to design and to test the validity and reliability of an instrument to evaluate coaches' knowledge about the female athlete triad syndrome and their confidence in this knowledge. The instrument collects information regarding: knowledge of the syndrome, components, prevention and intervention; confidence of the coaches in their answers; and coach's characteristics (gender, degree held, years of experience in coaching females, continuing education participation specific to the syndrome and its components, and sport coached. The process of designing the questionnaire and testing the validity and reliability of it was done in four phases: a design and development of the instrument, b content validity, c instrument reliability, and d concurrent validity. The results show that the instrument is suitable for measuring coaches' female athlete triad knowledge. The instrument can contribute to assessing the coaches' knowledge level in relation to this topic.

The design, validation, and performance of Grace

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Ru Zhu

2016-05-01

Full Text Available The design, validation and performance of Grace, a GPU-accelerated micromagnetic simulation software, are presented. The software adopts C+ + Accelerated Massive Parallelism (C+ + AMP so that it runs on GPUs from various hardware vendors including NVidia, AMD and Intel. At large simulation scales, up to two orders of magnitude of speedup factor is observed, compared to CPU-based micromagnetic simulation software OOMMF. The software can run on high-end professional GPUs as well as budget personal laptops, and is free to download.

Updated Design Standards and Guidance from the What Works Clearinghouse: Regression Discontinuity Designs and Cluster Designs

Science.gov (United States)

Cole, Russell; Deke, John; Seftor, Neil

2016-01-01

The What Works Clearinghouse (WWC) maintains design standards to identify rigorous, internally valid education research. As education researchers advance new methodologies, the WWC must revise its standards to include an assessment of the new designs. Recently, the WWC has revised standards for two emerging study designs: regression discontinuity…

Validation plays the role of a "bridge" in connecting remote sensing research and applications

Science.gov (United States)

Wang, Zhiqiang; Deng, Ying; Fan, Yida

2018-07-01

Remote sensing products contribute to improving earth observations over space and time. Uncertainties exist in products of different levels; thus, validation of these products before and during their applications is critical. This study discusses the meaning of validation in depth and proposes a new definition of reliability for use with such products. In this context, validation should include three aspects: a description of the relevant uncertainties, quantitative measurement results and a qualitative judgment that considers the needs of users. A literature overview is then presented evidencing improvements in the concepts associated with validation. It shows that the root mean squared error (RMSE) is widely used to express accuracy; increasing numbers of remote sensing products have been validated; research institutes contribute most validation efforts; and sufficient validation studies encourage the application of remote sensing products. Validation plays a connecting role in the distribution and application of remote sensing products. Validation connects simple remote sensing subjects with other disciplines, and it connects primary research with practical applications. Based on the above findings, it is suggested that validation efforts that include wider cooperation among research institutes and full consideration of the needs of users should be promoted.

Research design and statistical analysis

CERN Document Server

Myers, Jerome L; Lorch Jr, Robert F

2013-01-01

Research Design and Statistical Analysis provides comprehensive coverage of the design principles and statistical concepts necessary to make sense of real data.  The book's goal is to provide a strong conceptual foundation to enable readers to generalize concepts to new research situations.  Emphasis is placed on the underlying logic and assumptions of the analysis and what it tells the researcher, the limitations of the analysis, and the consequences of violating assumptions.  Sampling, design efficiency, and statistical models are emphasized throughout. As per APA recommendations

On the Problem of Validity of Qualitative Research

Directory of Open Access Journals (Sweden)

Jo Reichertz

2000-06-01

Full Text Available Whether the research results put forth by (social scientists on behalf of their professional vocation and on behalf of their professional standards they adhere to, can be regarded as valid, shall be examined from the perspective of the sociology of knowledge. By means of applying the sociology of knowledge to its own research results, it shall be shown that research and research results are inevitably bound to perspective (in fact, not a surprising insight. Therefore—so the underlying thesis of the argument—, research must be aimed at the systematic production of doubt in order to facilitate maximum extinction of fault. Suggestions are advanced of how qualitative research projects can be defended despite the increasing competition regarding research grants and despite the problematic epistemological position. URN: urn:nbn:de:0114-fqs0002324

Design and validation of a questionnaire to assess organizational culture in French hospital wards.

Science.gov (United States)

Saillour-Glénisson, F; Domecq, S; Kret, M; Sibe, M; Dumond, J P; Michel, P

2016-09-17

Although many organizational culture questionnaires have been developed, there is a lack of any validated multidimensional questionnaire assessing organizational culture at hospital ward level and adapted to health care context. Facing the lack of an appropriate tool, a multidisciplinary team designed and validated a dimensional organizational culture questionnaire for healthcare settings to be administered at ward level. A database of organizational culture items and themes was created after extensive literature review. Items were regrouped into dimensions and subdimensions (classification validated by experts). Pre-test and face validation was conducted with 15 health care professionals. In a stratified cluster random sample of hospitals, the psychometric validation was conducted in three phases on a sample of 859 healthcare professionals from 36 multidisciplinary medicine services: 1) the exploratory phase included a description of responses' saturation levels, factor and correlations analyses and an internal consistency analysis (Cronbach's alpha coefficient); 2) confirmatory phase used the Structural Equation Modeling (SEM); 3) reproducibility was studied by a test-retest. The overall response rate was 80 %; the completion average was 97 %. The metrological results were: a global Cronbach's alpha coefficient of 0.93, higher than 0.70 for 12 sub-dimensions; all Dillon-Goldstein's rho coefficients higher than 0.70; an excellent quality of external model with a Goodness of Fitness (GoF) criterion of 0.99. Seventy percent of the items had a reproducibility ranging from moderate (Intra-Class Coefficient between 50 and 70 % for 25 items) to good (ICC higher than 70 % for 33 items). COMEt (Contexte Organisationnel et Managérial en Etablissement de Santé) questionnaire is a validated multidimensional organizational culture questionnaire made of 6 dimensions, 21 sub-dimensions and 83 items. It is the first dimensional organizational culture questionnaire

Development and Validation of a Rubric for Diagnosing Students' Experimental Design Knowledge and Difficulties.

Science.gov (United States)

Dasgupta, Annwesa P; Anderson, Trevor R; Pelaez, Nancy

2014-01-01

It is essential to teach students about experimental design, as this facilitates their deeper understanding of how most biological knowledge was generated and gives them tools to perform their own investigations. Despite the importance of this area, surprisingly little is known about what students actually learn from designing biological experiments. In this paper, we describe a rubric for experimental design (RED) that can be used to measure knowledge of and diagnose difficulties with experimental design. The development and validation of the RED was informed by a literature review and empirical analysis of undergraduate biology students' responses to three published assessments. Five areas of difficulty with experimental design were identified: the variable properties of an experimental subject; the manipulated variables; measurement of outcomes; accounting for variability; and the scope of inference appropriate for experimental findings. Our findings revealed that some difficulties, documented some 50 yr ago, still exist among our undergraduate students, while others remain poorly investigated. The RED shows great promise for diagnosing students' experimental design knowledge in lecture settings, laboratory courses, research internships, and course-based undergraduate research experiences. It also shows potential for guiding the development and selection of assessment and instructional activities that foster experimental design. © 2014 A. P. Dasgupta et al. CBE—Life Sciences Education © 2014 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

On various metrics used for validation of predictive QSAR models with applications in virtual screening and focused library design.

Science.gov (United States)

Roy, Kunal; Mitra, Indrani

2011-07-01

Quantitative structure-activity relationships (QSARs) have important applications in drug discovery research, environmental fate modeling, property prediction, etc. Validation has been recognized as a very important step for QSAR model development. As one of the important objectives of QSAR modeling is to predict activity/property/toxicity of new chemicals falling within the domain of applicability of the developed models and QSARs are being used for regulatory decisions, checking reliability of the models and confidence of their predictions is a very important aspect, which can be judged during the validation process. One prime application of a statistically significant QSAR model is virtual screening for molecules with improved potency based on the pharmacophoric features and the descriptors appearing in the QSAR model. Validated QSAR models may also be utilized for design of focused libraries which may be subsequently screened for the selection of hits. The present review focuses on various metrics used for validation of predictive QSAR models together with an overview of the application of QSAR models in the fields of virtual screening and focused library design for diverse series of compounds with citation of some recent examples.

Design and Implementation of Data Collection Instruments for Neonatology Research

Directory of Open Access Journals (Sweden)

Monica G. HĂŞMĂŞANU

2014-12-01

Full Text Available im: The aim of our research was to design and implement data collection instruments to be use in context of an observational prospective clinical study with follow-up conducted on new born with intrauterine growth restriction. Methods: The structure of the data collection forms (paper based and electronic based was first identified and for each variable the best type to accomplish the research aim was established. The code for categorical variables has also been decided as well as the units of measurements for quantitative variables. In respect of good practice, a set of confounding factors (as gender, date of birth, etc. have also been identified and integrated in data collection instruments. Data-entry validation rules were implemented for each variable to reduce data input errors when the electronic data collection instrument was created. Results: Two data collection instruments have been developed and successfully implemented: a paper-based form and an electronic data collection instrument. The developed forms included demographics, neonatal complications (as hypoglycemia, hypocalcemia, etc., biochemical data at birth and follow-up, immunological data, as well as basal and follow-up echocardiographic data. Data-entry validation criteria have been implemented in electronic data collection instrument to assure validity and precision when paper-based data are translated in electronic form. Furthermore, to assure subject’s confidentiality a careful attention was given to HIPPA identifiers when electronic data collection instrument was developed. Conclusion: Data collection instruments were successfully developed and implemented as an a priori step in a clinical research for assisting data collection and management in a case of an observational prospective study with follow-up visits.

Fashion Research at Design Schools

DEFF Research Database (Denmark)

Skjold, Else

2008-01-01

The report “Fashion Research at Design Schools” (2008), which was commissioned by Institute for Fashion and Textiles at Designskolen Kolding,  appoints the potentials and challenges in relation to the ongoing academization of design schools, with a specific focus on fashion research. The key......, interactionistic interviews (Järvinen and Mik-Meyer, 2005) with key persons from the respective research- and fashion departments from eight selected design schools in Holland, England and USA. The analysis of each case is inspired by Edgar E. Schein’s levels of culture (Schein 1994), that aims to pinpoint both...

Design and Validation of the Quantum Mechanics Conceptual Survey

Science.gov (United States)

McKagan, S. B.; Perkins, K. K.; Wieman, C. E.

2010-01-01

The Quantum Mechanics Conceptual Survey (QMCS) is a 12-question survey of students' conceptual understanding of quantum mechanics. It is intended to be used to measure the relative effectiveness of different instructional methods in modern physics courses. In this paper, we describe the design and validation of the survey, a process that included…

Initial Validation of a Technical Writing Rubric for Engineering Design

Directory of Open Access Journals (Sweden)

Cheryl Bodnar

2018-02-01

Full Text Available Engineering design serves as the capstone experience of most undergraduate engineering programs. One of the key elements of the engineering design process is the compilation of results obtained into a technical report that can be shared and distributed to interested stakeholders including industry, faculty members and other relevant parties. In an effort to expand the tools available for assessment of engineering design technical reports, this study performed an initial validation of a previously developed Technical Writing rubric. The rubric was evaluated for its reliability to measure the intended construct, inter-rater reliability and external validity in comparison to an existing generalized written communication rubric. It was found that the rubric was reliable with Cronbach’s alpha for all dimensions between 0.817 and 0.976. The inter-rater reliability for the overall instrument was also found to be excellent at 0.85. Finally, it was observed that there were no statistically significant differences observed between the measurements obtained on the Technical Writing rubric in comparison to the more generalized Written Communication Value rubric. This demonstrates that although specific to engineering design environments the Technical Writing rubric was able to measure key constructs associated with written communication practice. This rubric can now serve as one additional tool for assessment of communication skills within engineering capstone design experiences.

Development of knowledgebase system for assisting signal validation scheme design

International Nuclear Information System (INIS)

Kitamura, M.; Baba, T.; Washio, T.; Sugiyama, K.

1987-01-01

The purpose of this study is to develop a knowledgebase system to be used as a tool for designing signal validation schemes. The outputs from the signal validation scheme can be used as; (1) auxiliary signals for detecting sensor failures, (2) inputs to advanced instrumentation such as disturbance analysis and diagnosis system or safety parameter display system, and (3) inputs to digital control systems. Conventional signal validation techniques such as comparison of redundant sensors, limit checking, and calibration tests have been employed in nuclear power plants. However, these techniques have serious drawbacks, e.g. needs for extra sensors, vulnerability to common mode failures, limited applicability to continuous monitoring, etc. To alleviate these difficulties, a new signal validation technique has been developed by using the methods called analytic redundancy and parity space. Although the new technique has been proved feasible as far as preliminary tests are concerned, further developments should be made in order to enhance its practical applicability

Communicating Qualitative Research Study Designs to Research Ethics Review Boards

Science.gov (United States)

Ells, Carolyn

2011-01-01

Researchers using qualitative methodologies appear to be particularly prone to having their study designs called into question by research ethics or funding agency review committees. In this paper, the author considers the issue of communicating qualitative research study designs in the context of institutional research ethics review and offers…

Development and Validation of a Hypersonic Vehicle Design Tool Based On Waverider Design Technique

Science.gov (United States)

Dasque, Nastassja

Methodologies for a tool capable of assisting design initiatives for practical waverider based hypersonic vehicles were developed and validated. The design space for vehicle surfaces was formed using an algorithm that coupled directional derivatives with the conservation laws to determine a flow field defined by a set of post-shock streamlines. The design space is used to construct an ideal waverider with a sharp leading edge. A blunting method was developed to modify the ideal shapes to a more practical geometry for real-world application. Empirical and analytical relations were then systematically applied to the resulting geometries to determine local pressure, skin-friction and heat flux. For the ideal portion of the geometry, flat plate relations for compressible flow were applied. For the blunted portion of the geometry modified Newtonian theory, Fay-Riddell theory and Modified Reynolds analogy were applied. The design and analysis methods were validated using analytical solutions as well as empirical and numerical data. The streamline solution for the flow field generation technique was compared with a Taylor-Maccoll solution and showed very good agreement. The relationship between the local Stanton number and skin friction coefficient with local Reynolds number along the ideal portion of the body showed good agreement with experimental data. In addition, an automated grid generation routine was formulated to construct a structured mesh around resulting geometries in preparation for Computational Fluid Dynamics analysis. The overall analysis of the waverider body using the tool was then compared to CFD studies. The CFD flow field showed very good agreement with the design space. However, the distribution of the surface properties was near CFD results but did not have great agreement.

Deployable and Conformal Planar Micro-Devices: Design and Model Validation

Directory of Open Access Journals (Sweden)

Jinda Zhuang

2014-08-01

Full Text Available We report a design concept for a deployable planar microdevice and the modeling and experimental validation of its mechanical behavior. The device consists of foldable membranes that are suspended between flexible stems and actuated by push-pull wires. Such a deployable device can be introduced into a region of interest in its compact “collapsed” state and then deployed to conformally cover a large two-dimensional surface area for minimally invasive biomedical operations and other engineering applications. We develop and experimentally validate theoretical models based on the energy minimization approach to examine the conformality and figures of merit of the device. The experimental results obtained using model contact surfaces agree well with the prediction and quantitatively highlight the importance of the membrane bending modulus in controlling surface conformality. The present study establishes an early foundation for the mechanical design of this and related deployable planar microdevice concepts.

An exploratory sequential design to validate measures of moral emotions.

Science.gov (United States)

Márquez, Margarita G; Delgado, Ana R

2017-05-01

This paper presents an exploratory and sequential mixed methods approach in validating measures of knowledge of the moral emotions of contempt, anger and disgust. The sample comprised 60 participants in the qualitative phase when a measurement instrument was designed. Item stems, response options and correction keys were planned following the results obtained in a descriptive phenomenological analysis of the interviews. In the quantitative phase, the scale was used with a sample of 102 Spanish participants, and the results were analysed with the Rasch model. In the qualitative phase, salient themes included reasons, objects and action tendencies. In the quantitative phase, good psychometric properties were obtained. The model fit was adequate. However, some changes had to be made to the scale in order to improve the proportion of variance explained. Substantive and methodological im-plications of this mixed-methods study are discussed. Had the study used a single re-search method in isolation, aspects of the global understanding of contempt, anger and disgust would have been lost.

Advantages of the nested case-control design in diagnostic research

Directory of Open Access Journals (Sweden)

Hoes Arno W

2008-07-01

Full Text Available Abstract Background Despite its benefits, it is uncommon to apply the nested case-control design in diagnostic research. We aim to show advantages of this design for diagnostic accuracy studies. Methods We used data from a full cross-sectional diagnostic study comprising a cohort of 1295 consecutive patients who were selected on their suspicion of having deep vein thrombosis (DVT. We draw nested case-control samples from the full study population with case:control ratios of 1:1, 1:2, 1:3 and 1:4 (per ratio 100 samples were taken. We calculated diagnostic accuracy estimates for two tests that are used to detect DVT in clinical practice. Results Estimates of diagnostic accuracy in the nested case-control samples were very similar to those in the full study population. For example, for each case:control ratio, the positive predictive value of the D-dimer test was 0.30 in the full study population and 0.30 in the nested case-control samples (median of the 100 samples. As expected, variability of the estimates decreased with increasing sample size. Conclusion Our findings support the view that the nested case-control study is a valid and efficient design for diagnostic studies and should also be (reappraised in current guidelines on diagnostic accuracy research.

The Validity and Precision of the Comparative Interrupted Time-Series Design: Three Within-Study Comparisons

Science.gov (United States)

St. Clair, Travis; Hallberg, Kelly; Cook, Thomas D.

2016-01-01

We explore the conditions under which short, comparative interrupted time-series (CITS) designs represent valid alternatives to randomized experiments in educational evaluations. To do so, we conduct three within-study comparisons, each of which uses a unique data set to test the validity of the CITS design by comparing its causal estimates to…

Evaluation in Design-Oriented Research

NARCIS (Netherlands)

Verschuren, P.J.M.; Hartog, R.J.M.

2005-01-01

Design has been recognized for a long time both as art and as science. In the sixties of the previous century design-oriented research began to draw the attention of scientific researchers and methodologists, not only in technical engineering but also in the social sciences. However, a rather

Using qualitative repertory grid interviews to gather shared perspectives in a sequential mixed methods research design

OpenAIRE

Rojon, C; Saunders, M.N.K.; McDowall, Almuth

2016-01-01

In this chapter, we consider a specific example of applying mixed methods designs combining both qualitative and quantitative data collection and analysis approaches, giving particular attention to issues including reliability and validity. Human resource management (HRM) researchers, like others setting out to examine a novel or insufficiently defined research topic, frequently favour qualitative approaches to gather data during initial stages, to facilitate an in-depth exploration of indivi...

Manufacturing system design based on axiomatic design: Case of assembly line

Energy Technology Data Exchange (ETDEWEB)

Hager, T.; Wafik, H.; Faouzi, M.

2017-07-01

In this paper, a combined Production Line Design (PLD) process which includes many design aspects is presented, developed and validated. Design/methodology/approach: The PLD process is based on the SADT (Structured Analysis and Design Technique) diagram and the Axiomatic Design (AD) method. Practical implications: For a purpose of validation, this proposed process has been applied in a manufacturing company and it has been validated by simulation. Findings: The results of the validation indicated that the production line designed by this process is outperformed the initial line of the company. Originality/value: Recently, the problems of production line design (PLD) have attracted the attention of many researchers. However, only a few studies have treated the PLD which includes all design aspects. In this work, a combined PLD process is presented. It should be noted that the proposed process is simple and effective.

Manufacturing system design based on axiomatic design: Case of assembly line

International Nuclear Information System (INIS)

Hager, T.; Wafik, H.; Faouzi, M.

2017-01-01

In this paper, a combined Production Line Design (PLD) process which includes many design aspects is presented, developed and validated. Design/methodology/approach: The PLD process is based on the SADT (Structured Analysis and Design Technique) diagram and the Axiomatic Design (AD) method. Practical implications: For a purpose of validation, this proposed process has been applied in a manufacturing company and it has been validated by simulation. Findings: The results of the validation indicated that the production line designed by this process is outperformed the initial line of the company. Originality/value: Recently, the problems of production line design (PLD) have attracted the attention of many researchers. However, only a few studies have treated the PLD which includes all design aspects. In this work, a combined PLD process is presented. It should be noted that the proposed process is simple and effective.

An Integrated Mixed Methods Research Design: Example of the Project Foreign Language Learning Strategies and Achievement: Analysis of Strategy Clusters and Sequences

OpenAIRE

Vlčková Kateřina

2014-01-01

The presentation focused on an so called integrated mixed method research design example on a basis of a Czech Science Foundation Project Nr. GAP407/12/0432 "Foreign Language Learning Strategies and Achievement: Analysis of Strategy Clusters and Sequences". All main integrated parts of the mixed methods research design were discussed: the aim, theoretical framework, research question, methods and validity threats. Prezentace se zaměřovala na tzv. integrovaný vícemetodový výzkumný design na...

Implementing an online pharmaceutical service using design science research.

Science.gov (United States)

Lapão, Luís Velez; da Silva, Miguel Mira; Gregório, João

2017-03-27

The rising prevalence of chronic diseases is pressing health systems to introduce reforms. Primary healthcare and multidisciplinary models have been suggested as approaches to deal with this challenge, with new roles for nurses and pharmacists being advocated. More recently, implementing healthcare based on information systems and technologies (e.g. eHealth) has been proposed as a way to improve health services. However, implementing online pharmaceutical services, including their adoption by pharmacists and patients, is still an open research question. In this paper we present ePharmacare, a new online pharmaceutical service implemented using Design Science Research. The Design Science Research Methodology (DSRM) was chosen to implement this online service for chronic diseases management. In the paper, DSRM's different activities are explained, from the definition of the problem to the evaluation of the artifact. During the design and development activities, surveys, observations, focus groups, and eye-tracking glasses were used to validate pharmacists' and patients' requirements. During the demonstration and evaluation activities the new service was used with real-world pharmacists and patients. The results show the contribution of DSRM in the implementation of online services for pharmacies. We found that pharmacists spend only 50% of their time interacting with patients, uncovering a clear opportunity to implement online pharmaceutical care services. On the other hand, patients that regularly visit the same pharmacy recognize the value in patient follow-up demanding to use channels such as the Internet for their pharmacy interactions. Limitations were identified regarding the high workload of pharmacists, but particularly their lack of know-how and experience in dealing with information systems (IST) for the provision of pharmaceutical services. This paper summarizes a research project in which an online pharmaceutical service was proposed, designed, developed

Fashion Research at Design Schools

DEFF Research Database (Denmark)

Skjold, Else

2008-01-01

on fashion education and fashion research, that are “taken for granted” in the institutional culture of each case. Because of the diversity between the cases, a cultural-oriented comparison has been made, where every case is perceived as idiographically unique (Thyge Winther-Jensen 2004). Descriptions......The report “Fashion Research at Design Schools” (2008), which was commissioned by Institute for Fashion and Textiles at Designskolen Kolding,  appoints the potentials and challenges in relation to the ongoing academization of design schools, with a specific focus on fashion research. The key...... research question is: “What kind of fashion design education is Designskolen Kolding aiming to offer in the future, what kind of skills will the students need in their future work place, the fashion industry, and can research work as a potential in this process?”   The study is based on qualitative...

Research oriented projects on design themese

DEFF Research Database (Denmark)

Tollestrup, Christian; Eriksen, Kaare; Ovesen, Nis

2011-01-01

How can design students do research-oriented projects about design themes? At the 3rd semester at the Industrial Design Master Program at Aalborg University this is done by taking research oriented learning objectives on design theories and methods and combining them with experimental case studie...... and professional self-reflection amongst students are improved....

The MMPI-2-RF Personality Psychopathology Five (PSY-5-RF) scales: development and validity research.

Science.gov (United States)

Harkness, Allan R; McNulty, John L; Finn, Jacob A; Reynolds, Shannon M; Shields, Susan M; Arbisi, Paul

2014-01-01

This article describes the development, internal psychometric, and external validation studies on scales designed to measure the Personality Psychopathology Five (PSY-5) from MMPI-2 Restructured Form (MMPI-2-RF) items. Diverse and comprehensive data sets, representing various clinical and nonclinical populations, were classified into development and validation research samples. Item selection, retention, and exclusion procedures are detailed. The final set of PSY-5-RF scales contain 104 items, with no item overlap between scales (same as the original MMPI-2 PSY-5 scales), and no item overlap with the Demoralization scale. Internal consistency estimates are comparable to the longer MMPI-2 PSY-5 scales. Appropriate convergent and discriminant validity findings utilizing various self-report, collateral rating, and record review data are reported and discussed. A particular emphasis is offered for the unique aspects of the PSY-5 model: psychoticism and disconstraint. The findings are connected to the broader PSY-5 literature and the recommended review of systems (Harkness, Reynolds, & Lilienfeld, this issue) presented in this series of articles.

CONCEPTUAL AND DESIGN ISSUES IN INSTRUMENT DEVELOPMENT FOR RESEARCH WITH BEREAVED PARENTS*

Science.gov (United States)

Briller, Sherylyn H.; Schim, Stephanie Myers; Thurston, Celia S.; Meert, Kathleen L.

2013-01-01

Many childhood deaths in the United States occur in pediatric intensive care units (PICUs) and parents have special needs in this death context. As an interdisciplinary research team, we discuss conceptual and design issues encountered in creating a new instrument, the Bereaved Parent Needs Assessment–PICU, for assessing parents’ needs in this setting. Using a qualitative approach, our team previously explored how the culture and related ways of providing care in one urban Midwestern children’s hospital PICU affected parents’ bereavement needs and experiences. We describe using this qualitative foundation in the development of a new quantitative instrument to more widely validate and measure bereaved parents’ needs around the time of a child’s death across multiple PICUs. We highlight a series of issues that warrant consideration in designing a research instrument for this vulnerable population including setting and context, format and content, temporality, recruitment, and content expertise. PMID:22953511

RAZORBACK - A Research Reactor Transient Analysis Code Version 1.0 - Volume 3: Verification and Validation Report.

Energy Technology Data Exchange (ETDEWEB)

Talley, Darren G.

2017-04-01

This report describes the work and results of the verification and validation (V&V) of the version 1.0 release of the Razorback code. Razorback is a computer code designed to simulate the operation of a research reactor (such as the Annular Core Research Reactor (ACRR)) by a coupled numerical solution of the point reactor kinetics equations, the energy conservation equation for fuel element heat transfer, the equation of motion for fuel element thermal expansion, and the mass, momentum, and energy conservation equations for the water cooling of the fuel elements. This V&V effort was intended to confirm that the code shows good agreement between simulation and actual ACRR operations.

Embedding the perceptions of people with dementia into quantitative research design.

Science.gov (United States)

O'Rourke, Hannah M; Duggleby, Wendy; Fraser, Kimberly D

2015-05-01

Patient perspectives about quality of life are often found in the results of qualitative research and could be applied to steer the direction of future research. The purpose of this paper was to describe how findings from a body of qualitative research on patient perspectives about quality of life were linked to a clinical administrative dataset and then used to design a subsequent quantitative study. Themes from two systematic reviews of qualitative evidence (i.e., metasyntheses) identified what affects quality of life according to people with dementia. Selected themes and their sub-concepts were then mapped to an administrative dataset (the Resident Assessment Instrument 2.0) to determine the study focus, formulate nine hypotheses, and select a patient-reported outcome. A literature review followed to confirm existence of a knowledge gap, identify adjustment variables, and support design decisions. A quantitative study to test the association between conflict and sadness for people with dementia in long-term care was derived from metasynthesis themes. Challenges included (1) mapping broad themes to the administrative dataset; (2) decisions associated with inclusion of variables not identified by people with dementia from the qualitative research; and (3) selecting a patient-reported outcome, when the dataset lacked a valid subjective quality-of-life measure. Themes derived from a body of qualitative research capturing a target populations' perspective can be linked to administrative data and used to design a quantitative study. Using this approach, the quantitative findings will be meaningful with respect to the quality of life of the target population.

Game design research: an introduction to theory & practice

OpenAIRE

Lankoski, Petri; Holopainen, Jussi

2017-01-01

Design research is an active academic field covering disciplines such as architecture, graphic, product, service, interaction, and systems design. Design research aims to understand not only the designed end products but also how design as an activity unfolds. The book demonstrates different approaches to design research in game design research.

Validation of Reactor Physics-Thermal hydraulics Calculations for Research Reactors Cooled by the Laminar Flow of Water

Energy Technology Data Exchange (ETDEWEB)

Jordan, K. A.; Schubring, D. [Univ. of Florida, Florida (United States); Girardin, G.; Pautz, A. [Swiss Federal Institute of Technology, Zuerich (Switzerland)

2013-07-01

A collaboration between the University of Florida and the Swiss Federal Institute of Technology, Lausanne (EPFL) has been formed to develop and validate detailed coupled multiphysics models of the zero-power (100 W) CROCUS reactor at EPFL and the 100 kW University of Florida Training Reactor, for the comprehensive analysis of the reactor behavior under transient (neutronic or thermal-hydraulic induced) conditions. These two reactors differ significantly in the core design and thermal power output, but share unique heat transfer and flow characteristics. They are characterized by single-phase laminar water flow at near-atmospheric pressures in complex geometries with the possibility of mechanically entrained air bubbles. Validation experiments will be designed to expand the validation domain of these existing models, computational codes and techniques. In this process, emphasis will be placed on validation of the coupled models developed to gain confidence in their applicability for safety analysis. EPFL is responsible for the design and implementation of transient experiments to generate a database of reactor parameters (flow distribution, power profile, and power evolution) to be used to validate against code predictions. The transient experiments performed at EPFL will be simulated on the basis of developed models for these tasks. Comparative analysis will be performed with SERPENT and MCNPX reference core models. UF focuses on the generation of the coupled neutron kinetics and thermal-hydraulic models, including implementation of a TRACE/PARCS reactor simulator model, a PARET model, and development of full-field computational fluid dynamics models (using OpenFOAM) for refined thermal-hydraulics physics treatments. In this subtask of the project, the aim is to verify by means of CFD the validity of TRACE predictions for near-atmospheric pressure water flow in the presence of mechanically entrained air bubbles. The scientific understanding of these multiphysics

Validation of Reactor Physics-Thermal hydraulics Calculations for Research Reactors Cooled by the Laminar Flow of Water

International Nuclear Information System (INIS)

Jordan, K. A.; Schubring, D.; Girardin, G.; Pautz, A.

2013-01-01

A collaboration between the University of Florida and the Swiss Federal Institute of Technology, Lausanne (EPFL) has been formed to develop and validate detailed coupled multiphysics models of the zero-power (100 W) CROCUS reactor at EPFL and the 100 kW University of Florida Training Reactor, for the comprehensive analysis of the reactor behavior under transient (neutronic or thermal-hydraulic induced) conditions. These two reactors differ significantly in the core design and thermal power output, but share unique heat transfer and flow characteristics. They are characterized by single-phase laminar water flow at near-atmospheric pressures in complex geometries with the possibility of mechanically entrained air bubbles. Validation experiments will be designed to expand the validation domain of these existing models, computational codes and techniques. In this process, emphasis will be placed on validation of the coupled models developed to gain confidence in their applicability for safety analysis. EPFL is responsible for the design and implementation of transient experiments to generate a database of reactor parameters (flow distribution, power profile, and power evolution) to be used to validate against code predictions. The transient experiments performed at EPFL will be simulated on the basis of developed models for these tasks. Comparative analysis will be performed with SERPENT and MCNPX reference core models. UF focuses on the generation of the coupled neutron kinetics and thermal-hydraulic models, including implementation of a TRACE/PARCS reactor simulator model, a PARET model, and development of full-field computational fluid dynamics models (using OpenFOAM) for refined thermal-hydraulics physics treatments. In this subtask of the project, the aim is to verify by means of CFD the validity of TRACE predictions for near-atmospheric pressure water flow in the presence of mechanically entrained air bubbles. The scientific understanding of these multiphysics

An underground research tunnel for the validation of high-level radioactive waste disposal concept

International Nuclear Information System (INIS)

Kwon, S.; Park, S. I.; Park, J. H.; Cho, W. J.; Han, P. S.

2005-01-01

In order to dispose of high-level radioactive waste(HLW) safely in geological formations, it is necessary to assess the feasibility, safety, appropriateness, and stability of the disposal concept at an underground research site, which is constructed in the same geological formation as the host rock. In this study, minimum requirements and the conceptual design for an efficient construction of a small scale URL, which is named URT, were derived based on a literature review. To confirm the validity of the conceptual design for construction at KAERI, a geological survey including a seismic refraction survey, electronic resistivity survey, borehole drilling, and in situ and laboratory tests were carried out. Based on the results, it was possible to design URT effectively with a consideration of the site characterization. The construction of URT was started in May 2005 and the first stage of the construction of the access tunnel could be successfully completed in Aug. 2005

Design research and industrial applicability

DEFF Research Database (Denmark)

Andreasen, Mogens Myrup

1997-01-01

Imprinted paper (copies of overheads in English) on the nature of design research, the transformation process for industrial utilization and the challenges of ENDREA from industry.......Imprinted paper (copies of overheads in English) on the nature of design research, the transformation process for industrial utilization and the challenges of ENDREA from industry....

A Research Design for NASA-Funded Professional Development Projects

Science.gov (United States)

Bleicher, R. E.; Lambert, J.; Getty, S. R.

2011-12-01

This proposal outlines a research plan designed to measure gains in student learning resulting from their teachers participating in professional development. Project Description Misconceptions about global climate change (GCC) are prevalent in the general public (Kellstedt, Zahran, & Vedlitz, 2008; Washington & Cook, 2011). One solution is to provide high school students with a better grounding in the basic science and data that underlie GCC. The overarching goal of a NASA-funded project, Promoting Educational Leadership in Climate Change Literacy (PEL), is to increase GCC literacy in high school students. Research Design The research design is interpretative (Erickson, 2006), framed within a multi-method design, synthesizing both quantitative and qualitative data sources (Morse, 2003). Overall, the data will provide rich information about the PEL's impact on curriculum development, teacher pedagogical knowledge, and student learning. The expectancy-value theory of achievement motivation (E-V-C) (Fan, 2011; Wigfield & Eccles, 1994) provides a theoretical foundation for the research. Expectancy is the degree to which a teacher or student has reason to expect that they will be successful in school. Value indicates whether they think that performance at school will be worthwhile to them. Cost is the perceived sacrifices that must be undertaken, or factors that can inhibit, a successful performance at school. For students, data from an embedded E-V-C investigation will help articulate how E-V-C factors relate to student interest in science, continuing to study science, or embarking on STEM related careers. For teachers, the E-V-C measures will give insight into a key mediating variable on student achievement in science. The evaluation will seek to address research questions at the student and teacher levels. Table 1 presents a sample of research questions and data sources. This is a sample of a much larger set of questions that will be addressed in the project. Data

How Design-based Research, Action Research and Interaction Design Contributes to the Development of Designs for Learning

DEFF Research Database (Denmark)

Majgaard, Gunver; Misfeldt, Morten; Nielsen, Jacob

2011-01-01

This article explores how action research, design based research and interaction design can be combined and used in the development of educational robotic tools. Our case study is the development of Number Blocks and it combines physical interaction, learning, and immediate feedback. Number Blocks...... supports the children's understanding of place value in the sense that it allows them to experiment with creating large numbers. The development was done in collaboration with a class of 7-8 year old children and their mathematics teacher. The article argues that elements from different research methods...... allowed a structured approach to projects that combines educational research and innovation of new learning technologies. Key elements of this approach is acknowledging the users input, developing a theoretical pre-analysis and using an iterative approach....

Interdisciplinary research and trans-disciplinary validity claims

CERN Document Server

Gethmann, C F; Hanekamp, G; Kaiser, M; Kamp, G; Lingner, S; Quante, M; Thiele, F

2015-01-01

Interdisciplinarity has seemingly become a paradigm for modern and meaningful research. Clearly, the interdisciplinary modus of deliberation enables to unfold relevant but quite different disciplinary perspectives to the reflection of broader scientific questions or societal problems. However, whether the comprehensive results of interdisciplinary reflection prove to be valid or to be acceptable in trans-disciplinary terms depends upon certain preconditions, which have to be fulfilled for securing scientific quality and social trust in advisory contexts. The present book is written by experts and practitioners of interdisciplinary research and policy advice. It analyses topical and methodological approaches towards interdisciplinarity, starting with the current role of scientific research in society. The volume continues with contributions to the issues of knowledge and acting and to trans-disciplinary deliberation. The final conclusions address the scientific system as substantial actor itself as well as the...

The Laboratory Course Assessment Survey: A Tool to Measure Three Dimensions of Research-Course Design

Science.gov (United States)

Corwin, Lisa A.; Runyon, Christopher; Robinson, Aspen; Dolan, Erin L.

2015-01-01

Course-based undergraduate research experiences (CUREs) are increasingly being offered as scalable ways to involve undergraduates in research. Yet few if any design features that make CUREs effective have been identified. We developed a 17-item survey instrument, the Laboratory Course Assessment Survey (LCAS), that measures students’ perceptions of three design features of biology lab courses: 1) collaboration, 2) discovery and relevance, and 3) iteration. We assessed the psychometric properties of the LCAS using established methods for instrument design and validation. We also assessed the ability of the LCAS to differentiate between CUREs and traditional laboratory courses, and found that the discovery and relevance and iteration scales differentiated between these groups. Our results indicate that the LCAS is suited for characterizing and comparing undergraduate biology lab courses and should be useful for determining the relative importance of the three design features for achieving student outcomes. PMID:26466990

A methodology for the validated design space exploration of fuel cell powered unmanned aerial vehicles

Science.gov (United States)

Moffitt, Blake Almy

Unmanned Aerial Vehicles (UAVs) are the most dynamic growth sector of the aerospace industry today. The need to provide persistent intelligence, surveillance, and reconnaissance for military operations is driving the planned acquisition of over 5,000 UAVs over the next five years. The most pressing need is for quiet, small UAVs with endurance beyond what is capable with advanced batteries or small internal combustion propulsion systems. Fuel cell systems demonstrate high efficiency, high specific energy, low noise, low temperature operation, modularity, and rapid refuelability making them a promising enabler of the small, quiet, and persistent UAVs that military planners are seeking. Despite the perceived benefits, the actual near-term performance of fuel cell powered UAVs is unknown. Until the auto industry began spending billions of dollars in research, fuel cell systems were too heavy for useful flight applications. However, the last decade has seen rapid development with fuel cell gravimetric and volumetric power density nearly doubling every 2--3 years. As a result, a few design studies and demonstrator aircraft have appeared, but overall the design methodology and vehicles are still in their infancy. The design of fuel cell aircraft poses many challenges. Fuel cells differ fundamentally from combustion based propulsion in how they generate power and interact with other aircraft subsystems. As a result, traditional multidisciplinary analysis (MDA) codes are inappropriate. Building new MDAs is difficult since fuel cells are rapidly changing in design, and various competitive architectures exist for balance of plant, hydrogen storage, and all electric aircraft subsystems. In addition, fuel cell design and performance data is closely protected which makes validation difficult and uncertainty significant. Finally, low specific power and high volumes compared to traditional combustion based propulsion result in more highly constrained design spaces that are

Applied statistical designs for the researcher

CERN Document Server

Paulson, Daryl S

2003-01-01

Research and Statistics Basic Review of Parametric Statistics Exploratory Data Analysis Two Sample Tests Completely Randomized One-Factor Analysis of Variance One and Two Restrictions on Randomization Completely Randomized Two-Factor Factorial Designs Two-Factor Factorial Completely Randomized Blocked Designs Useful Small Scale Pilot Designs Nested Statistical Designs Linear Regression Nonparametric Statistics Introduction to Research Synthesis and "Meta-Analysis" and Conclusory Remarks References Index.

Benchmark of physics design of a proposed 30 MW Multi Purpose Research Reactor using a Monte Carlo code MCNP

International Nuclear Information System (INIS)

Singh, Tej; Kumar, Jainendra; Sharma, Archana; Singh, Kanchhi; Raina, V.K.; Srinivasan, P.

2009-01-01

At present Dhruva and Cirus reactors provide majority of research reactor based experimental/irradiation facilities to cater to various needs of the vast pool of researchers in the field of sciences research and development work for nuclear power plants and production of radioisotopes. With a view to further consolidate and expand the scope of research and development in nuclear and allied sciences, a new 30 MWt Multi Purpose Research Reactor is proposed to be constructed. This paper describes some of the physics design features of this reactor using MCNP code to validate the deterministic methods. The criticality calculations for 100 material testing reactor (JHR) of France and 610 MW SAVANNAH thermal reactor were performed using MCNP computer codes to boost the confidence level in designing the physics design of reactor core. (author)

Designing interaction, voice, and inclusion in AAC research.

Science.gov (United States)

Pullin, Graham; Treviranus, Jutta; Patel, Rupal; Higginbotham, Jeff

2017-09-01

The ISAAC 2016 Research Symposium included a Design Stream that examined timely issues across augmentative and alternative communication (AAC), framed in terms of designing interaction, designing voice, and designing inclusion. Each is a complex term with multiple meanings; together they represent challenging yet important frontiers of AAC research. The Design Stream was conceived by the four authors, researchers who have been exploring AAC and disability-related design throughout their careers, brought together by a shared conviction that designing for communication implies more than ensuring access to words and utterances. Each of these presenters came to AAC from a different background: interaction design, inclusive design, speech science, and social science. The resulting discussion among 24 symposium participants included controversies about the role of technology, tensions about independence and interdependence, and a provocation about taste. The paper concludes by proposing new directions for AAC research: (a) new interdisciplinary research could combine scientific and design research methods, as distant yet complementary as microanalysis and interaction design, (b) new research tools could seed accessible and engaging contextual research into voice within a social model of disability, and (c) new open research networks could support inclusive, international and interdisciplinary research.

Development and Validation of the Survey of Organizational Research Climate (SORC)

Science.gov (United States)

Martinson, Brian C.; Thrush, Carol R.; Crain, A. Lauren

2012-01-01

Background Development and targeting efforts by academic organizations to effectively promote research integrity can be enhanced if they are able to collect reliable data to benchmark baseline conditions, to assess areas needing improvement, and to subsequently assess the impact of specific initiatives. To date, no standardized and validated tool has existed to serve this need. Methods A web- and mail-based survey was administered in the second half of 2009 to 2,837 randomly selected biomedical and social science faculty and postdoctoral fellows at 40 academic health centers in top-tier research universities in the United States. Measures included the Survey of Organizational Research Climate (SORC) as well as measures of perceptions of organizational justice. Results Exploratory and confirmatory factor analyses yielded seven subscales of organizational research climate, all of which demonstrated acceptable internal consistency (Cronbach’s α ranging from 0.81 to 0.87) and adequate test-retest reliability (Pearson r ranging from 0.72 to 0.83). A broad range of correlations between the seven subscales and five measures of organizational justice (unadjusted regression coefficients ranging from .13 to .95) document both construct and discriminant validity of the instrument. Conclusions The SORC demonstrates good internal (alpha) and external reliability (test-retest) as well as both construct and discriminant validity. PMID:23096775

Development and validation of the Survey of Organizational Research Climate (SORC).

Science.gov (United States)

Martinson, Brian C; Thrush, Carol R; Lauren Crain, A

2013-09-01

Development and targeting efforts by academic organizations to effectively promote research integrity can be enhanced if they are able to collect reliable data to benchmark baseline conditions, to assess areas needing improvement, and to subsequently assess the impact of specific initiatives. To date, no standardized and validated tool has existed to serve this need. A web- and mail-based survey was administered in the second half of 2009 to 2,837 randomly selected biomedical and social science faculty and postdoctoral fellows at 40 academic health centers in top-tier research universities in the United States. Measures included the Survey of Organizational Research Climate (SORC) as well as measures of perceptions of organizational justice. Exploratory and confirmatory factor analyses yielded seven subscales of organizational research climate, all of which demonstrated acceptable internal consistency (Cronbach's α ranging from 0.81 to 0.87) and adequate test-retest reliability (Pearson r ranging from 0.72 to 0.83). A broad range of correlations between the seven subscales and five measures of organizational justice (unadjusted regression coefficients ranging from 0.13 to 0.95) document both construct and discriminant validity of the instrument. The SORC demonstrates good internal (alpha) and external reliability (test-retest) as well as both construct and discriminant validity.

Intermediate/Advanced Research Design and Statistics

Science.gov (United States)

Ploutz-Snyder, Robert

2009-01-01

The purpose of this module is To provide Institutional Researchers (IRs) with an understanding of the principles of advanced research design and the intermediate/advanced statistical procedures consistent with such designs

Design-validation of a hand exoskeleton using musculoskeletal modeling.

Science.gov (United States)

Hansen, Clint; Gosselin, Florian; Ben Mansour, Khalil; Devos, Pierre; Marin, Frederic

2018-04-01

Exoskeletons are progressively reaching homes and workplaces, allowing interaction with virtual environments, remote control of robots, or assisting human operators in carrying heavy loads. Their design is however still a challenge as these robots, being mechanically linked to the operators who wear them, have to meet ergonomic constraints besides usual robotic requirements in terms of workspace, speed, or efforts. They have in particular to fit the anthropometry and mobility of their users. This traditionally results in numerous prototypes which are progressively fitted to each individual person. In this paper, we propose instead to validate the design of a hand exoskeleton in a fully digital environment, without the need for a physical prototype. The purpose of this study is thus to examine whether finger kinematics are altered when using a given hand exoskeleton. Therefore, user specific musculoskeletal models were created and driven by a motion capture system to evaluate the fingers' joint kinematics when performing two industrial related tasks. The kinematic chain of the exoskeleton was added to the musculoskeletal models and its compliance with the hand movements was evaluated. Our results show that the proposed exoskeleton design does not influence fingers' joints angles, the coefficient of determination between the model with and without exoskeleton being consistently high (R 2 ¯=0.93) and the nRMSE consistently low (nRMSE¯ = 5.42°). These results are promising and this approach combining musculoskeletal and robotic modeling driven by motion capture data could be a key factor in the ergonomics validation of the design of orthotic devices and exoskeletons prior to manufacturing. Copyright © 2017 Elsevier Ltd. All rights reserved.

Conceptual strategy for design, implementation, and validation of a biomarker-based biomonitoring capability

Energy Technology Data Exchange (ETDEWEB)

McCarthy, J.F.; Halbrook, R.S.; Shugart, L.R.

1991-12-01

This document describes a strategy for defining specific objectives for biomarker studies and for designing and implementing a biomonitoring study that focuses on these objectives. In researching this subject, it became clear to the authors that the subject of biomarkers created a great deal of interest among scientists and regulators but that general acceptance of biomarkers as a tool for environmental protection was hampered by lack of a clear notion of how to develop and apply this approach. We intend this document to be a user's guide'' that lays out a logical scheme for applying biomarkers in environmental monitoring. In addition, laboratory and field research components needed to develop and validate fundamental understanding and interpretation of biomarker responses are also described, as is a strategy for evolution of a biomarker-based biomonitoring capability. The document is divided into sections intended to lead the reader to an understanding of how biomarkers can be developed and applied.

Conceptual strategy for design, implementation, and validation of a biomarker-based biomonitoring capability

Energy Technology Data Exchange (ETDEWEB)

McCarthy, J.F.; Halbrook, R.S.; Shugart, L.R.

1991-12-01

This document describes a strategy for defining specific objectives for biomarker studies and for designing and implementing a biomonitoring study that focuses on these objectives. In researching this subject, it became clear to the authors that the subject of biomarkers created a great deal of interest among scientists and regulators but that general acceptance of biomarkers as a tool for environmental protection was hampered by lack of a clear notion of how to develop and apply this approach. We intend this document to be a ``user`s guide`` that lays out a logical scheme for applying biomarkers in environmental monitoring. In addition, laboratory and field research components needed to develop and validate fundamental understanding and interpretation of biomarker responses are also described, as is a strategy for evolution of a biomarker-based biomonitoring capability. The document is divided into sections intended to lead the reader to an understanding of how biomarkers can be developed and applied.

Conducting Educational Design Research

Science.gov (United States)

McKenney, Susan; Reeves, Thomas

2012-01-01

Educational design research blends scientific investigation with systematic development and implementation of solutions to educational problems. Empirical investigation is conducted in real learning settings--not laboratories--to craft usable and effective solutions. At the same time, the research is carefully structured to produce theoretical…

Experimental design research approaches, perspectives, applications

CERN Document Server

Stanković, Tino; Štorga, Mario

2016-01-01

This book presents a new, multidisciplinary perspective on and paradigm for integrative experimental design research. It addresses various perspectives on methods, analysis and overall research approach, and how they can be synthesized to advance understanding of design. It explores the foundations of experimental approaches and their utility in this domain, and brings together analytical approaches to promote an integrated understanding. The book also investigates where these approaches lead to and how they link design research more fully with other disciplines (e.g. psychology, cognition, sociology, computer science, management). Above all, the book emphasizes the integrative nature of design research in terms of the methods, theories, and units of study—from the individual to the organizational level. Although this approach offers many advantages, it has inherently led to a situation in current research practice where methods are diverging and integration between individual, team and organizational under...

The Role of Hypothesis in Constructive Design Research

DEFF Research Database (Denmark)

Bang, Anne Louise; Krogh, Peter; Ludvigsen, Martin

2012-01-01

It is, today, widely appreciated that Research-through-Design – or Constructive Design Research as we will call it in this paper – allows for designers to produce knowledge based on the skills and capacities of the design field itself. However, most of the research fails to bridge the gap between...... the general notions of constructive design research and the detailed research activities of the field. We therefore suggest bridging this methodological gap in the academic discussion with what we have ended up calling the “entrance level of constructive design research”. As a step towards to a more nuanced...... and solid perspective on how to keep constructive design research on track, this paper offers a model for understanding the role of hypothesis in constructive design research. The model allows for understanding the hypothesis’s relation to research motivation, questions, experiments, evaluation...

Design verification and validation plan for the cold vacuum drying facility

International Nuclear Information System (INIS)

NISHIKAWA, L.D.

1999-01-01

The Cold Vacuum Drying Facility (CVDF) provides the required process systems, supporting equipment, and facilities needed for drying spent nuclear fuel removed from the K Basins. This document presents the both completed and planned design verification and validation activities

[Design and validation of a brief questionnaire to assess young´s sexual knowledge].

Science.gov (United States)

Leon-Larios, Fátima; Gómez-Baya, Diego

2018-06-01

Only very few instruments have been developed to assess sexual knowledge and practices. Most of the research to date has been carried out with adolescent samples, but not with university students, who are also at a particularly risky stage. The aim of this study was to design and validate a brief questionnaire to assess young´s sexual knowledge, practices and behaviors to design health education programs in the university context. We created a specific questionnaire about sexual pattern in university adolescents and a brief questionnaire consisted of 9 items (true/false) about contraception, sexuality and sexual transmission diseases. We carried out a pilot study, reliability (KR-20) and validity analyses using factorial analysis and examining the association with other variables. 566 students from University of Seville participated during 2015/16. One item was eliminated because of comprehension (only 13.9% of correct answers) and weak or non significant associations (p more than 0.05). Finally, the scale was formed by 8 items and had good internal consistency reliability (KR-20 = 0.57), and both factorial and external validity reliability. A three-factor model showed good data fit, χ2 (14, N=566)=17.48, p= 0.232, Comparative Fit Index CFI = 0.97, root mean squared error of prediction RMSEA = 0.02. Participants with less knowledge about sexuality were whose did not receive any information (M=6.82, SD=1.41), without partner (M=6.87, SD=1.35), had an abortion (M=6.43, SD=1.95) and did not use any contraceptive method (M=6.66, SD=0.58) or coitus interruptus (M=6.55, SD=1.39), and had less sexual relationships, e.g., once or twice a year (M=6.49, SD=1.70). This questionnaire is a short instrument to assess students´ practices and knowledge about sexuality and contraception. The analyses of reliability and validity have shown the good psychometric properties of this instrument.

Beyond Borders: Participatory Design Research and the Changing Role of Design

Science.gov (United States)

Blair-Early, Adream

2010-01-01

University art and design programs are branching out and creating cross-disciplinary programs and research centers that connect design students and faculty across various disciplines such as business, engineering, architecture, information studies, health sciences and education. A human-centered, problem-based approach to design research looks to…

An Integrated Research Infrastructure for Validating Cyber-Physical Energy Systems

DEFF Research Database (Denmark)

Strasser, T. I.; Moyo, C.; Bründlinger, R.

2017-01-01

quality and ensure security of supply. At the same time, the increased availability of advanced automation and communication technologies provides new opportunities for the derivation of intelligent solutions to tackle the challenges. Previous work has shown various new methods of operating highly...... interconnected power grids, and their corresponding components, in a more effective way. As a consequence of these developments, the traditional power system is being transformed into a cyber-physical energy system, a smart grid. Previous and ongoing research have tended to mainly focus on how specific aspects...... of smart grids can be validated, but until there exists no integrated approach for the analysis and evaluation of complex cyber-physical systems configurations. This paper introduces integrated research infrastructure that provides methods and tools for validating smart grid systems in a holistic, cyber...

Multiyear Plan for Validation of EnergyPlus Multi-Zone HVAC System Modeling using ORNL's Flexible Research Platform

Energy Technology Data Exchange (ETDEWEB)

Im, Piljae [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bhandari, Mahabir S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); New, Joshua Ryan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2016-10-01

This document describes the Oak Ridge National Laboratory (ORNL) multiyear experimental plan for validation and uncertainty characterization of whole-building energy simulation for a multi-zone research facility using a traditional rooftop unit (RTU) as a baseline heating, ventilating, and air conditioning (HVAC) system. The project’s overarching objective is to increase the accuracy of energy simulation tools by enabling empirical validation of key inputs and algorithms. Doing so is required to inform the design of increasingly integrated building systems and to enable accountability for performance gaps between design and operation of a building. The project will produce documented data sets that can be used to validate key functionality in different energy simulation tools and to identify errors and inadequate assumptions in simulation engines so that developers can correct them. ASHRAE Standard 140, Method of Test for the Evaluation of Building Energy Analysis Computer Programs (ASHRAE 2004), currently consists primarily of tests to compare different simulation programs with one another. This project will generate sets of measured data to enable empirical validation, incorporate these test data sets in an extended version of Standard 140, and apply these tests to the Department of Energy’s (DOE) EnergyPlus software (EnergyPlus 2016) to initiate the correction of any significant deficiencies. The fitness-for-purpose of the key algorithms in EnergyPlus will be established and demonstrated, and vendors of other simulation programs will be able to demonstrate the validity of their products. The data set will be equally applicable to validation of other simulation engines as well.

Using design science in educational technology research projects

Directory of Open Access Journals (Sweden)

Susan M. Chard

2017-12-01

Full Text Available Design science is a research paradigm where the development and evaluation of a technology artefact is a key contribution. Design science is used in many domains and this paper draws on those domains to formulate a generic structure for design science research suitable for educational technology research projects. The paper includes guidelines for writing proposals using the design science research methodology for educational technology research and presents a generic research report structure. The paper presents ethical issues to consider in design science research being conducted in educational settings and contributes guidelines for assessment when the research contribution involves the creation of a technology artefact.

Design and development of driving simulator scenarios for road validation studies

Energy Technology Data Exchange (ETDEWEB)

Dols Ruiz, J.F.

2016-07-01

In recent years, the number of road-based studies using driving simulators is growing significantly. This allows evaluating controlled situations that otherwise would require disproportionate observations in time and/or cost. The Institute of Design and Manufacturing (IDF) of the Polytechnic University of Valencia (UPV) has developed, in collaboration with the Engineering Research Group Highway (GIIC) of the UPV, a low cost simulator that allows rapid implementation and effectively a new methodology for validation studies of different roads through the implementation in the simulator scenarios of existing roads. This methodology allows the development of new scenarios based on the analysis of a layers-file system. Each layer includes different information from the road, such as mapping, geometry, signaling, aerial photos, etc. The creation of the simulated scenario is very fast based on the geometric design software, making it easier to consulting firms using the system that can evaluate and audit a particular route, obtaining reliable conclusions at minimal cost, even if the road is not actually built. This paper describes the basic structure of the layers generated for developing scenarios and guidelines for the implementation thereof. Finally the application of this methodology to a case of success will be described. (Author)

The validity of the schizophrenia diagnosis in the Danish Psychiatric Central Research Register is good

DEFF Research Database (Denmark)

Uggerby, Peter; Østergaard, Søren Dinesen; Røge, Rasmus

2013-01-01

INTRODUCTION: The Danish Psychiatric Central Research Register (DPCRR) has been used extensively for research purposes during the past decades. The aim of this study was to investigate the validity of the International Classification of Diseases (ICD)-10 schizophrenia diagnosis in the DPCRR...... all 300 case records, the validity of the schizophrenia diagnosis was 89.7%. CONCLUSION: According to this assessment of patient case records, the diagnosis of schizophrenia in the DPCRR has a high validity and is well-suited for research. FUNDING: Aalborg Psychiatric Hospital funded the study...

Design research and the globalization of healthcare environments.

Science.gov (United States)

Shepley, Mardelle McCuskey; Song, Yilin

2014-01-01

Global healthcare practice has expanded in the past 20 years. At the same time the incorporation of research into the design process has gained prominence as a best practice among architects. The authors of this study investigated the status of design research in a variety of international settings. We intended to answer the question, "how pervasive is healthcare design research outside of the United States?" The authors reviewed the international literature on the design of healthcare facilities. More than 500 international studies and conference proceedings were incorporated in this literature review. A team of five research assistants searched multiple databases comparing approximately 16 keywords to geographic location. Some of those keywords included: evidence-based design, salutogenic design, design research, and healthcare environment. Additional articles were gathered by contacting prominent researchers and asking for their personal assessment of local health design research studies. While there are design researchers in most parts of the world, the majority of studies focus on the needs of populations in developed countries and generate guidelines that have significant cost and cultural implications that prohibit their implementation in developing countries. Additionally, the body of literature discussing the role of culture in healthcare environments is extremely limited. Design researchers must address the cultural implications of their studies. Additionally, we need to expand our research objectives to address healthcare design in countries that have not been previous considered. © 2014 Vendome Group, LLC.

The global status of freshwater fish age validation studies and a prioritization framework for future research

Science.gov (United States)

Pope, Kevin L.; Hamel, Martin J.; Pegg, Mark A.; Spurgeon, Jonathan J.

2016-01-01

Age information derived from calcified structures is commonly used to estimate recruitment, growth, and mortality for fish populations. Validation of daily or annual marks on age structures is often assumed, presumably due to a lack of general knowledge concerning the status of age validation studies. Therefore, the current status of freshwater fish age validation studies was summarized to show where additional effort is needed, and increase the accessibility of validation studies to researchers. In total, 1351 original peer-reviewed articles were reviewed from freshwater systems that studied age in fish. Periodicity and age validation studies were found for 88 freshwater species comprising 21 fish families. The number of age validation studies has increased over the last 30 years following previous calls for more research; however, few species have validated structures spanning all life stages. In addition, few fishes of conservation concern have validated ageing structures. A prioritization framework, using a combination of eight characteristics, is offered to direct future age validation studies and close the validation information gap. Additional study, using the offered prioritization framework, and increased availability of published studies that incorporate uncertainty when presenting research results dealing with age information are needed.

The Role of Hypothesis in Constructive Design Research

OpenAIRE

Bang, Anne Louise; Krogh, Peter; Ludvigsen, Martin; Markussen, Thomas

2012-01-01

It is, today, widely appreciated that Research-through-Design – or Constructive Design Research as we will call it in this paper – allows for designers to produce knowledge based on the skills and capacities of the design field itself.However, most of the research fails to bridge the gap between the general notions of constructive design research and the detailed research activities of the field. We therefore suggest bridging this methodological gap in the academic discussion with what we hav...

Design of a Hydro-Turbine Blade for Acoustic and Performance Validation Studies

Science.gov (United States)

Johnson, E.; Barone, M.

2011-12-01

To meet the growing, global energy demands governments and industry have recently begun to focus on marine hydrokinetic (MHK) devices as an additional form of power generation. Water turbines have become a popular design choice since they are able to leverage experience from the decades-old wind industry in the hope of decreasing time-to-market. However, the difference in environments poses challenges that need to be addressed. In particular, little research has addressed the acoustic effects of common aerofoils in a marine setting. This has both a potential impact on marine life and may cause early fatigue by exciting new structural modes. An initial blade design is presented, which has been used to begin characterization of any structural and acoustic issues that may arise from a direct one-to-one swap of wind technologies into MHK devices. The blade was optimized for performance using blade-element momentum theory while requiring that it not exceed the allowable stress under a specified extreme operating design condition. This limited the maximum power generated, while ensuring a realizable blade. A stress analysis within ANSYS was performed to validate the structural integrity of the design. Additionally, predictions of the radiated noise from the MHK rotor will be made using boundary element modeling based on flow results from ANSYS CFX, a computational fluid dynamics (CFD) code. The FEA and CFD results demonstrate good comparison to the expected design. Determining a range for the anticipated noise produced from a MHK turbine provides a look at the environmental impact these devices will have. Future efforts will focus on the design constraints noise generation places on MHK devices.

Research and Design in Landscape Architecture

NARCIS (Netherlands)

Nijhuis, S.; Bobbink, I.; Jauslin, D.T.

2011-01-01

This paper aims to introduce the particular methodology of the author's and their colleagues at TU Delft Chair of Landscape Architecture. This approach is characterised by theories, methods and techniques converging towards design and research and research by design. The relation and interaction

Design and Validation of CRISPR/Cas9 Systems for Targeted Gene Modification in Induced Pluripotent Stem Cells.

Science.gov (United States)

Lee, Ciaran M; Zhu, Haibao; Davis, Timothy H; Deshmukh, Harshahardhan; Bao, Gang

2017-01-01

The CRISPR/Cas9 system is a powerful tool for precision genome editing. The ability to accurately modify genomic DNA in situ with single nucleotide precision opens up new possibilities for not only basic research but also biotechnology applications and clinical translation. In this chapter, we outline the procedures for design, screening, and validation of CRISPR/Cas9 systems for targeted modification of coding sequences in the human genome and how to perform genome editing in induced pluripotent stem cells with high efficiency and specificity.

Psychometric validation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Endometrial Cancer Module (EORTC QLQ-EN24)

DEFF Research Database (Denmark)

Greimel, Elfriede; Nordin, Andy; Lanceley, Anne

2011-01-01

A validation study was conducted to evaluate the psychometric properties of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Endometrial Cancer Module (EORTC QLQ-EN24). This module was designed to assess disease and treatment specific aspects of...

Human factors engineering and design validation for the redesigned follitropin alfa pen injection device.

Science.gov (United States)

Mahony, Mary C; Patterson, Patricia; Hayward, Brooke; North, Robert; Green, Dawne

2015-05-01

To demonstrate, using human factors engineering (HFE), that a redesigned, pre-filled, ready-to-use, pre-asembled follitropin alfa pen can be used to administer prescribed follitropin alfa doses safely and accurately. A failure modes and effects analysis identified hazards and harms potentially caused by use errors; risk-control measures were implemented to ensure acceptable device use risk management. Participants were women with infertility, their significant others, and fertility nurse (FN) professionals. Preliminary testing included 'Instructions for Use' (IFU) and pre-validation studies. Validation studies used simulated injections in a representative use environment; participants received prior training on pen use. User performance in preliminary testing led to IFU revisions and a change to outer needle cap design to mitigate needle stick potential. In the first validation study (49 users, 343 simulated injections), in the FN group, one observed critical use error resulted in a device design modification and another in an IFU change. A second validation study tested the mitigation strategies; previously reported use errors were not repeated. Through an iterative process involving a series of studies, modifications were made to the pen design and IFU. Simulated-use testing demonstrated that the redesigned pen can be used to administer follitropin alfa effectively and safely.

Development of lithium target system in engineering validation and engineering design activity of the international fusion materials irradiation facility (IFMIF/EVEDA)

International Nuclear Information System (INIS)

Wakai, Eiichi; Kondo, Hiroo; Sugimoto, Masayoshi; Ida, Mizuho; Kanemura, Takuji; Watanabe, Kazuyoshi; Fujishiro, Kouji; Edao, Yuuki; Niitsuma, Shigeto; Kimura, Haruyuki; Fukada, Satoshi; Hiromoto, Tetsushi; Shigeharu, Satoshi; Yagi, Jyuro; Furukawa, Tomohiro; Hirakawa, Yasushi; Suzuki, Akihiro; Terai, Takayuki; Horiike, Hiroshi; Hoashi, Eiji; Suzuki, Sachiko; Yamaoka, Nobuo; Serizawa, Hisashi; Kawahito, Yosuke; Tsuji, Yoshiyuki; Furuya, Kazuyuki; Takeo, Fumio

2012-01-01

Engineering validation and engineering design activity (EVEDA) for the international fusion materials irradiation facility (IFMIF) has been conducted since 2007. Research and development of the Lithium target facility is an important part of this activity. We constructed a world largest liquid Lithium test loop with a capacity of 5000 L in 2010 and successfully completed the first stage validation tests (functional tests of components and Lithium flow test (flow velocity 15 m/s at the target). In the present article, recent results of the EVEDA activity for the Lithium target facility and related technologies on liquid Lithium are reviewed. (author)

Reconsidering the Utility of Case Study Designs for Researching School Reform in a Neo-Scientific Era: Insights from a Multiyear, Mixed-Methods Study

Science.gov (United States)

Donmoyer, Robert; Galloway, Fred

2010-01-01

In recent years, policy makers and researchers once again have embraced the traditional idea that quasi-experimental research designs (or reasonable facsimiles) can provide the sort of valid and generalizable knowledge about "what works" that educational researchers had promised--but never really produced--during the previous century. Although…

Enhancing Validity When Researching the "Other": Insights from Pierre Bourdieu's Theory of Social Science Research Practice

Science.gov (United States)

Naidoo, Devika

2014-01-01

This article explores aspects of Pierre Bourdieu's theory of social science research practice and discusses their relevance for enhancing validity when researching the "other." Aspects such as: a relational way of thinking about concepts, epistemology and methodology; the rigorous construction of the object of research; and…

Reinventing Learning: A Design-Research Odyssey

Science.gov (United States)

Abrahamson, Dor

2015-01-01

Design research is a broad, practice-based approach to investigating problems of education. This approach can catalyze the development of learning theory by fostering opportunities for transformational change in scholars' interpretation of instructional interactions. Surveying a succession of design-research projects, I explain how challenges in…

Generation After Next Propulsor Research: Robust Design for Embedded Engine Systems

Science.gov (United States)

Arend, David J.; Tillman, Gregory; O'Brien, Walter F.

2012-01-01

The National Aeronautics and Space Administration, United Technologies Research Center and Virginia Polytechnic and State University have contracted to pursue multi-disciplinary research into boundary layer ingesting (BLI) propulsors for generation after next environmentally responsible subsonic fixed wing aircraft. This Robust Design for Embedded Engine Systems project first conducted a high-level vehicle system study based on a large commercial transport class hybrid wing body aircraft, which determined that a 3 to 5 percent reduction in fuel burn could be achieved over a 7,500 nanometer mission. Both pylon-mounted baseline and BLI propulsion systems were based on a low-pressure-ratio fan (1.35) in an ultra-high-bypass ratio engine (16), consistent with the next generation of advanced commercial turbofans. An optimized, coupled BLI inlet and fan system was subsequently designed to achieve performance targets identified in the system study. The resulting system possesses an inlet with total pressure losses less than 0.5%, and a fan stage with an efficiency debit of less than 1.5 percent relative to the pylon-mounted, clean-inflow baseline. The subject research project has identified tools and methodologies necessary for the design of next-generation, highly-airframe-integrated propulsion systems. These tools will be validated in future large-scale testing of the BLI inlet / fan system in NASA's 8 foot x 6 foot transonic wind tunnel. In addition, fan unsteady response to screen-generated total pressure distortion is being characterized experimentally in a JT15D engine test rig. These data will document engine sensitivities to distortion magnitude and spatial distribution, providing early insight into key physical processes that will control BLI propulsor design.

Research Design – Composition, Configuration and Interdependencies

DEFF Research Database (Denmark)

Kastberg, Peter

2016-01-01

In this essay I will present an integrative view on research design. I will introduce what I take to be the skeleton components of any research design within the social sciences, i.e. the elements of research question, philosophy of science, methodology, method and data. With this as my point...... of departure I will go on to focus on a presentation, a discussion and an evaluation of a new appreciation of the interdependencies of the elements in the research design. An appreciation that favors a relational rather than an atomistic outlook and which gives rise to an ecological conceptualization......). At a more concrete level, it aims at presenting an idea of research design which would – hopefully – be an inspiration to (young) scholars....

Design and validation of inert homemade explosive simulants for X-ray-based inspection systems

Science.gov (United States)

Faust, Anthony A.; Nacson, Sabatino; Koffler, Bruce; Bourbeau, Éric; Gagne, Louis; Laing, Robin; Anderson, C. J.

2014-05-01

Transport Canada (TC), the Canadian Armed Forces, and other public security agencies have an interest in the assessment of the potential utility of advanced explosives detection technologies to aid in the detection and interdiction of commercial grade, military grade, and homemade or improvised explosives (HME or IE). The availability of suitable, non-hazardous, non-toxic, explosive simulants is of concern when assessing the potential utility of such detection systems. Lack of simulants limits the training opportunities, and ultimately the detection probability, of security personnel using these systems. While simulants for commercial and military grade explosives are available for a wide variety of detection technologies, the design and production of materials to simulate improvised explosives has not kept pace with this emerging threat. Funded by TC and the Canadian Safety and Security Program, Defence Research and Development Canada (DRDC), Visiontec Systems, and Optosecurity engaged in an effort to develop inert, non-toxic Xray interrogation simulants for IE materials such as ammonium nitrate, potassium chlorate, and triacetone triperoxide. These simulants were designed to mimic key X-ray interrogation-relevant material properties of real improvised explosives, principally their bulk density and effective atomic number. Different forms of the simulants were produced and tested, simulating the different explosive threat formulations that could be encountered by front line security workers. These simulants comply with safety and stability requirements, and as best as possible match form and homogeneity. This paper outlines the research program, simulant design, and validation.

Experimental design technique applied to the validation of an instrumental Neutron Activation Analysis procedure

International Nuclear Information System (INIS)

Santos, Uanda Paula de M. dos; Moreira, Edson Gonçalves

2017-01-01

In this study optimization of procedures and standardization of Instrumental Neutron Activation Analysis (INAA) method were carried out for the determination of the elements bromine, chlorine, magnesium, manganese, potassium, sodium and vanadium in biological matrix materials using short irradiations at a pneumatic system. 2 k experimental designs were applied for evaluation of the individual contribution of selected variables of the analytical procedure in the final mass fraction result. The chosen experimental designs were the 2 3 and the 2 4 , depending on the radionuclide half life. Different certified reference materials and multi-element comparators were analyzed considering the following variables: sample decay time, irradiation time, counting time and sample distance to detector. Comparator concentration, sample mass and irradiation time were maintained constant in this procedure. By means of the statistical analysis and theoretical and experimental considerations, it was determined the optimized experimental conditions for the analytical methods that will be adopted for the validation procedure of INAA methods in the Neutron Activation Analysis Laboratory (LAN) of the Research Reactor Center (CRPq) at the Nuclear and Energy Research Institute (IPEN /CNEN-SP). Optimized conditions were estimated based on the results of z-score tests, main effect, interaction effects and better irradiation conditions. (author)

Experimental design technique applied to the validation of an instrumental Neutron Activation Analysis procedure

Energy Technology Data Exchange (ETDEWEB)

Santos, Uanda Paula de M. dos; Moreira, Edson Gonçalves, E-mail: uandapaula@gmail.com, E-mail: emoreira@ipen.br [Instituto de Pesquisas Energéticas e Nucleares (IPEN/CNEN-SP), São Paulo, SP (Brazil)

2017-07-01

In this study optimization of procedures and standardization of Instrumental Neutron Activation Analysis (INAA) method were carried out for the determination of the elements bromine, chlorine, magnesium, manganese, potassium, sodium and vanadium in biological matrix materials using short irradiations at a pneumatic system. 2{sup k} experimental designs were applied for evaluation of the individual contribution of selected variables of the analytical procedure in the final mass fraction result. The chosen experimental designs were the 2{sup 3} and the 2{sup 4}, depending on the radionuclide half life. Different certified reference materials and multi-element comparators were analyzed considering the following variables: sample decay time, irradiation time, counting time and sample distance to detector. Comparator concentration, sample mass and irradiation time were maintained constant in this procedure. By means of the statistical analysis and theoretical and experimental considerations, it was determined the optimized experimental conditions for the analytical methods that will be adopted for the validation procedure of INAA methods in the Neutron Activation Analysis Laboratory (LAN) of the Research Reactor Center (CRPq) at the Nuclear and Energy Research Institute (IPEN /CNEN-SP). Optimized conditions were estimated based on the results of z-score tests, main effect, interaction effects and better irradiation conditions. (author)

Playing to win over: validating persuasive games

NARCIS (Netherlands)

R.S. Jacobs (Ruud)

2017-01-01

textabstractThis dissertation describes four years of scientific inquiry into persuasive games – digital games designed to persuade – as part of a multidisciplinary research project ‘Persuasive Gaming. From Theory-Based Design to Validation and Back’ funded by the Netherlands Organization for

Evidence and research designs in applied sociology and social work research

DEFF Research Database (Denmark)

Høgsbro, Kjeld

2015-01-01

it had to be repeated all over again. This article tries to answer this question by reviewing the considerations in the history of applied sociology and its relevance for recent social work research. The ambition of delivering a research that has an impact on social work practice is not unique, neither...... of applied sociology and discusses its contributions to understanding questions of validity, evidence, methodology, practical relevance of research and scientific legitimacy in the areas of research which aim at contributing to the practical development of social services for marginalized people. By doing...... this, hopefully the history of applied sociology may prevent deeper mistakes, illusions and misleading in the development of social work research today....

76 FR 81991 - National Spectrum Sharing Research Experimentation, Validation, Verification, Demonstration and...

Science.gov (United States)

2011-12-29

... NATIONAL SCIENCE FOUNDATION National Spectrum Sharing Research Experimentation, Validation... requirements of national level spectrum research, development, demonstration, and field trial facilities... to determine the optimal way to manage and use the radio spectrum. During Workshop I held at Boulder...

An extended protocol for usability validation of medical devices : Research design and reference model

NARCIS (Netherlands)

Schmettow, M.; Schnittker, R.; Schraagen, J.M.

2017-01-01

This paper proposes and demonstrates an extended protocol for usability validation testing of medical devices. A review of currently used methods for the usability evaluation of medical devices revealed two main shortcomings. Firstly, the lack of methods to closely trace the interaction sequences

Conducting Classroom Design Research with Teachers

Science.gov (United States)

Stephan, Michelle. L.

2015-01-01

Design research is usually motivated by university members with experience and interest in building theory and instructional designs in collaboration with one teacher. Typically, the teacher is considered as a member of the research team, with the primary responsibility of implementing instruction. However, in this chapter, I describe a Classroom…

Design and validation of an MR-conditional robot for transcranial focused ultrasound surgery in infants

Energy Technology Data Exchange (ETDEWEB)

Price, Karl D., E-mail: karl.price@sickkids.ca [Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8 (Canada); The Department of Mechanical Engineering, The University of Toronto, Toronto, Ontario M5S 3G8 (Canada); Sin, Vivian W. [Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8 (Canada); Mougenot, Charles [Philips Healthcare Canada, Markham, Ontario L6C 2S3 (Canada); Pichardo, Samuel [Electrical Engineering, Lakehead University, Thunder Bay, Ontario P7B 5E1 (Canada); Looi, Thomas [Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8 (Canada); The Institute of Biomaterials and Biomedical Engineering, The University of Toronto, Toronto, Ontario M5G 3G9 (Canada); Waspe, Adam C. [Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8 (Canada); Department of Medical Imaging, The University of Toronto, Toronto, Ontario M5T 1W7 (Canada); Drake, James M. [Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8 (Canada); Department of Neurosurgery, The University of Toronto, Toronto, Ontario M5S 1A1 (Canada); The Institute of Biomaterials and Biomedical Engineering, The University of Toronto, Toronto, Ontario M5G 3G9 (Canada)

2016-09-15

Purpose: Current treatment of intraventricular hemorrhage (IVH) involves cerebral shunt placement or an invasive brain surgery. Magnetic resonance-guided focused ultrasound (MRgFUS) applied to the brains of pediatric patients presents an opportunity to treat IVH in a noninvasive manner, termed “incision-less surgery.” Current clinical and research focused ultrasound systems lack the capability to perform neonatal transcranial surgeries due to either range of motion or dexterity requirements. A novel robotic system is proposed to position a focused ultrasound transducer accurately above the head of a neonatal patient inside an MRI machine to deliver the therapy. Methods: A clinical Philips Sonalleve MRgFUS system was expanded to perform transcranial treatment. A five degree-of-freedom MR-conditional robot was designed and manufactured using MR compatible materials. The robot electronics and control were integrated into existing Philips electronics and software interfaces. The user commands the position of the robot with a graphical user interface, and is presented with real-time MR imaging of the patient throughout the surgery. The robot is validated through a series of experiments that characterize accuracy, signal-to-noise ratio degeneration of an MR image as a result of the robot, MR imaging artifacts generated by the robot, and the robot’s ability to operate in a representative surgical environment inside an MR machine. Results: Experimental results show the robot responds reliably within an MR environment, has achieved 0.59 ± 0.25 mm accuracy, does not produce severe MR-imaging artifacts, has a workspace providing sufficient coverage of a neonatal brain, and can manipulate a 5 kg payload. A full system demonstration shows these characteristics apply in an application environment. Conclusions: This paper presents a comprehensive look at the process of designing and validating a new robot from concept to implementation for use in an MR environment. An MR

Design and validation of an MR-conditional robot for transcranial focused ultrasound surgery in infants

International Nuclear Information System (INIS)

Price, Karl D.; Sin, Vivian W.; Mougenot, Charles; Pichardo, Samuel; Looi, Thomas; Waspe, Adam C.; Drake, James M.

2016-01-01

Purpose: Current treatment of intraventricular hemorrhage (IVH) involves cerebral shunt placement or an invasive brain surgery. Magnetic resonance-guided focused ultrasound (MRgFUS) applied to the brains of pediatric patients presents an opportunity to treat IVH in a noninvasive manner, termed “incision-less surgery.” Current clinical and research focused ultrasound systems lack the capability to perform neonatal transcranial surgeries due to either range of motion or dexterity requirements. A novel robotic system is proposed to position a focused ultrasound transducer accurately above the head of a neonatal patient inside an MRI machine to deliver the therapy. Methods: A clinical Philips Sonalleve MRgFUS system was expanded to perform transcranial treatment. A five degree-of-freedom MR-conditional robot was designed and manufactured using MR compatible materials. The robot electronics and control were integrated into existing Philips electronics and software interfaces. The user commands the position of the robot with a graphical user interface, and is presented with real-time MR imaging of the patient throughout the surgery. The robot is validated through a series of experiments that characterize accuracy, signal-to-noise ratio degeneration of an MR image as a result of the robot, MR imaging artifacts generated by the robot, and the robot’s ability to operate in a representative surgical environment inside an MR machine. Results: Experimental results show the robot responds reliably within an MR environment, has achieved 0.59 ± 0.25 mm accuracy, does not produce severe MR-imaging artifacts, has a workspace providing sufficient coverage of a neonatal brain, and can manipulate a 5 kg payload. A full system demonstration shows these characteristics apply in an application environment. Conclusions: This paper presents a comprehensive look at the process of designing and validating a new robot from concept to implementation for use in an MR environment. An MR

Designing Interactive Electronic Module in Chemistry Lessons

Science.gov (United States)

Irwansyah, F. S.; Lubab, I.; Farida, I.; Ramdhani, M. A.

2017-09-01

This research aims to design electronic module (e-module) oriented to the development of students’ chemical literacy on the solution colligative properties material. This research undergoes some stages including concept analysis, discourse analysis, storyboard design, design development, product packaging, validation, and feasibility test. Overall, this research undertakes three main stages, namely, Define (in the form of preliminary studies); Design (designing e-module); Develop (including validation and model trial). The concept presentation and visualization used in this e-module is oriented to chemical literacy skills. The presentation order carries aspects of scientific context, process, content, and attitude. Chemists and multi media experts have done the validation to test the initial quality of the products and give a feedback for the product improvement. The feasibility test results stated that the content presentation and display are valid and feasible to be used with the value of 85.77% and 87.94%. These values indicate that this e-module oriented to students’ chemical literacy skills for the solution colligative properties material is feasible to be used.

Using Network Science to Support Design Research

DEFF Research Database (Denmark)

Parraguez Ruiz, Pedro; Maier, Anja

2016-01-01

and societal impact. This chapter contributes to the use of network science in empirical studies of design organisations. It focuses on introducing a network-based perspective on the design process and in particular on making use of network science to support design research and practice. The main contribution...... of this chapter is an overview of the methodological challenges and core decision points when embarking on network-based design research, namely defining the overall research purpose and selecting network features. We furthermore highlight the potential for using archival data, the opportunities for navigating...

Criminal profiling as expert witness evidence: The implications of the profiler validity research.

Science.gov (United States)

Kocsis, Richard N; Palermo, George B

The use and development of the investigative tool colloquially known as criminal profiling has steadily increased over the past five decades throughout the world. Coupled with this growth has been a diversification in the suggested range of applications for this technique. Possibly the most notable of these has been the attempted transition of the technique from a tool intended to assist police investigations into a form of expert witness evidence admissible in legal proceedings. Whilst case law in various jurisdictions has considered with mutual disinclination the evidentiary admissibility of criminal profiling, a disjunction has evolved between these judicial examinations and the scientifically vetted research testing the accuracy (i.e., validity) of the technique. This article offers an analysis of the research directly testing the validity of the criminal profiling technique and the extant legal principles considering its evidentiary admissibility. This analysis reveals that research findings concerning the validity of criminal profiling are surprisingly compatible with the extant legal principles. The overall conclusion is that a discrete form of crime behavioural analysis is supported by the profiler validity research and could be regarded as potentially admissible expert witness evidence. Finally, a number of theoretical connections are also identified concerning the skills and qualifications of individuals who may feasibly provide such expert testimony. Copyright © 2016 Elsevier Ltd. All rights reserved.

AirSTAR Hardware and Software Design for Beyond Visual Range Flight Research

Science.gov (United States)

Laughter, Sean; Cox, David

2016-01-01

The National Aeronautics and Space Administration (NASA) Airborne Subscale Transport Aircraft Research (AirSTAR) Unmanned Aerial System (UAS) is a facility developed to study the flight dynamics of vehicles in emergency conditions, in support of aviation safety research. The system was upgraded to have its operational range significantly expanded, going beyond the line of sight of a ground-based pilot. A redesign of the airborne flight hardware was undertaken, as well as significant changes to the software base, in order to provide appropriate autonomous behavior in response to a number of potential failures and hazards. Ground hardware and system monitors were also upgraded to include redundant communication links, including ADS-B based position displays and an independent flight termination system. The design included both custom and commercially available avionics, combined to allow flexibility in flight experiment design while still benefiting from tested configurations in reversionary flight modes. A similar hierarchy was employed in the software architecture, to allow research codes to be tested, with a fallback to more thoroughly validated flight controls. As a remotely piloted facility, ground systems were also developed to ensure the flight modes and system state were communicated to ground operations personnel in real-time. Presented in this paper is a general overview of the concept of operations for beyond visual range flight, and a detailed review of the airborne hardware and software design. This discussion is held in the context of the safety and procedural requirements that drove many of the design decisions for the AirSTAR UAS Beyond Visual Range capability.

6th International Conference on Research into Design

CERN Document Server

Chakrabarti, Debkumar; ICoRD 2017; Research into design for communities

2017-01-01

This book showcases cutting-edge research papers from the 6th International Conference on Research into Design (ICoRD 2017) – the largest in India in this area – written by eminent researchers from across the world on design process, technologies, methods and tools, and their impact on innovation, for supporting design for communities. While design traditionally focused on the development of products for the individual, the emerging consensus on working towards a more sustainable world demands greater attention to designing for and with communities, so as to promote their sustenance and harmony - within each community and across communities. The special features of the book are the insights into the product and system innovation process, and the host of methods and tools from all major areas of design research for the enhancement of the innovation process. The main benefit of the book for researchers in various areas of design and innovation are access to the latest quality research in this area, with the...

Expert validation of fit-for-purpose guidelines for designing programmes of assessment

Directory of Open Access Journals (Sweden)

Dijkstra Joost

2012-04-01

Full Text Available Abstract Background An assessment programme, a purposeful mix of assessment activities, is necessary to achieve a complete picture of assessee competence. High quality assessment programmes exist, however, design requirements for such programmes are still unclear. We developed guidelines for design based on an earlier developed framework which identified areas to be covered. A fitness-for-purpose approach defining quality was adopted to develop and validate guidelines. Methods First, in a brainstorm, ideas were generated, followed by structured interviews with 9 international assessment experts. Then, guidelines were fine-tuned through analysis of the interviews. Finally, validation was based on expert consensus via member checking. Results In total 72 guidelines were developed and in this paper the most salient guidelines are discussed. The guidelines are related and grouped per layer of the framework. Some guidelines were so generic that these are applicable in any design consideration. These are: the principle of proportionality, rationales should underpin each decisions, and requirement of expertise. Logically, many guidelines focus on practical aspects of assessment. Some guidelines were found to be clear and concrete, others were less straightforward and were phrased more as issues for contemplation. Conclusions The set of guidelines is comprehensive and not bound to a specific context or educational approach. From the fitness-for-purpose principle, guidelines are eclectic, requiring expertise judgement to use them appropriately in different contexts. Further validation studies to test practicality are required.

RESEARCH UTILIZATION IN THE DESIGN DECISION MAKING PROCESS

Directory of Open Access Journals (Sweden)

Amy Huber

2016-04-01

Full Text Available This article summarizes findings from a national survey of interior design practitioners in the United States (N=366.  The study explored interior design practitioners' current preferences for conducting project research including: activities conducted and sources used, attraction to and recall from sources, and ideas for communicating research findings. Responses suggest that interior designers do value research, yet have little time to utilize research. While cross-tabulation analyses indicate no major differences in research activities between the study’s demographic groups, collectively, only 12% of the sample indicated they utilized academic journals and, at times, even incorrectly identified those sources. Open-ended responses allowed designers to offer ideas for communicating research and four key themes emerged, including: topic selection and relevancy, ideas for new dissemination methods, ideas for presentation style, and perceptions of the written language used.  It is hoped that this study’s findings may help design researchers better communicate their own findings to design practitioners.

Social validity in single-case research: A systematic literature review of prevalence and application.

Science.gov (United States)

Snodgrass, Melinda R; Chung, Moon Y; Meadan, Hedda; Halle, James W

2018-03-01

Single-case research (SCR) has been a valuable methodology in special education research. Montrose Wolf (1978), an early pioneer in single-case methodology, coined the term "social validity" to refer to the social importance of the goals selected, the acceptability of procedures employed, and the effectiveness of the outcomes produced in applied investigations. Since 1978, many contributors to SCR have included social validity as a feature of their articles and several authors have examined the prevalence and role of social validity in SCR. We systematically reviewed all SCR published in six highly-ranked special education journals from 2005 to 2016 to establish the prevalence of social validity assessments and to evaluate their scientific rigor. We found relatively low, but stable prevalence with only 28 publications addressing all three factors of the social validity construct (i.e., goals, procedures, outcomes). We conducted an in-depth analysis of the scientific rigor of these 28 publications. Social validity remains an understudied construct in SCR, and the scientific rigor of social validity assessments is often lacking. Implications and future directions are discussed. Copyright © 2018 Elsevier Ltd. All rights reserved.

Improving the validity of quantitative measures in applied linguistics research

NARCIS (Netherlands)

Purpura, J.E.; Brown, J.D.; Schoonen, R.

2015-01-01

In empirical applied linguistics research it is essential that the key variables are operationalized in a valid and reliable way, and that the scores are treated appropriately, allowing for a proper testing of the hypotheses under investigation. The current article addresses several theoretical and

Designing Effective Undergraduate Research Experiences

Science.gov (United States)

Severson, S.

2010-12-01

I present a model for designing student research internships that is informed by the best practices of the Center for Adaptive Optics (CfAO) Professional Development Program. The dual strands of the CfAO education program include: the preparation of early-career scientists and engineers in effective teaching; and changing the learning experiences of students (e.g., undergraduate interns) through inquiry-based "teaching laboratories." This paper will focus on the carry-over of these ideas into the design of laboratory research internships such as the CfAO Mainland internship program as well as NSF REU (Research Experiences for Undergraduates) and senior-thesis or "capstone" research programs. Key ideas in maximizing student learning outcomes and generating productive research during internships include: defining explicit content, scientific process, and attitudinal goals for the project; assessment of student prior knowledge and experience, then following up with formative assessment throughout the project; setting reasonable goals with timetables and addressing motivation; and giving students ownership of the research by implementing aspects of the inquiry process within the internship.

A Simulation Approach for Performance Validation during Embedded Systems Design

Science.gov (United States)

Wang, Zhonglei; Haberl, Wolfgang; Herkersdorf, Andreas; Wechs, Martin

Due to the time-to-market pressure, it is highly desirable to design hardware and software of embedded systems in parallel. However, hardware and software are developed mostly using very different methods, so that performance evaluation and validation of the whole system is not an easy task. In this paper, we propose a simulation approach to bridge the gap between model-driven software development and simulation based hardware design, by merging hardware and software models into a SystemC based simulation environment. An automated procedure has been established to generate software simulation models from formal models, while the hardware design is originally modeled in SystemC. As the simulation models are annotated with timing information, performance issues are tackled in the same pass as system functionality, rather than in a dedicated approach.

Using wound care algorithms: a content validation study.

Science.gov (United States)

Beitz, J M; van Rijswijk, L

1999-09-01

Valid and reliable heuristic devices facilitating optimal wound care are lacking. The objectives of this study were to establish content validation data for a set of wound care algorithms, to identify their associated strengths and weaknesses, and to gain insight into the wound care decision-making process. Forty-four registered nurse wound care experts were surveyed and interviewed at national and regional educational meetings. Using a cross-sectional study design and an 83-item, 4-point Likert-type scale, this purposive sample was asked to quantify the degree of validity of the algorithms' decisions and components. Participants' comments were tape-recorded, transcribed, and themes were derived. On a scale of 1 to 4, the mean score of the entire instrument was 3.47 (SD +/- 0.87), the instrument's Content Validity Index was 0.86, and the individual Content Validity Index of 34 of 44 participants was > 0.8. Item scores were lower for those related to packing deep wounds (P valid and reliable definitions. The wound care algorithms studied proved valid. However, the lack of valid and reliable wound assessment and care definitions hinders optimal use of these instruments. Further research documenting their clinical use is warranted. Research-based practice recommendations should direct the development of future valid and reliable algorithms designed to help nurses provide optimal wound care.

Schematic representation of case study research designs.

Science.gov (United States)

Rosenberg, John P; Yates, Patsy M

2007-11-01

The paper is a report of a study to demonstrate how the use of schematics can provide procedural clarity and promote rigour in the conduct of case study research. Case study research is a methodologically flexible approach to research design that focuses on a particular case - whether an individual, a collective or a phenomenon of interest. It is known as the 'study of the particular' for its thorough investigation of particular, real-life situations and is gaining increased attention in nursing and social research. However, the methodological flexibility it offers can leave the novice researcher uncertain of suitable procedural steps required to ensure methodological rigour. This article provides a real example of a case study research design that utilizes schematic representation drawn from a doctoral study of the integration of health promotion principles and practices into a palliative care organization. The issues discussed are: (1) the definition and application of case study research design; (2) the application of schematics in research; (3) the procedural steps and their contribution to the maintenance of rigour; and (4) the benefits and risks of schematics in case study research. The inclusion of visual representations of design with accompanying explanatory text is recommended in reporting case study research methods.

The water balance questionnaire: design, reliability and validity of a questionnaire to evaluate water balance in the general population.

Science.gov (United States)

Malisova, Olga; Bountziouka, Vassiliki; Panagiotakos, Demosthenes B; Zampelas, Antonis; Kapsokefalou, Maria

2012-03-01

There is a need to develop a questionnaire as a research tool for the evaluation of water balance in the general population. The water balance questionnaire (WBQ) was designed to evaluate water intake from fluid and solid foods and drinking water, and water loss from urine, faeces and sweat at sedentary conditions and physical activity. For validation purposes, the WBQ was administrated in 40 apparently healthy participants aged 22-57 years (37.5% males). Hydration indices in urine (24 h volume, osmolality, specific gravity, pH, colour) were measured through established procedures. Furthermore, the questionnaire was administered twice to 175 subjects to evaluate its reliability. Kendall's τ-b and the Bland and Altman method were used to assess the questionnaire's validity and reliability. The proposed WBQ to assess water balance in healthy individuals was found to be valid and reliable, and it could thus be a useful tool in future projects that aim to evaluate water balance.

Validation of computer codes used in the safety analysis of Canadian research reactors

International Nuclear Information System (INIS)

Bishop, W.E.; Lee, A.G.

1998-01-01

AECL has embarked on a validation program for the suite of computer codes that it uses in performing the safety analyses for its research reactors. Current focus is on codes used for the analysis of the two MAPLE reactors under construction at Chalk River but the program will be extended to include additional codes that will be used for the Irradiation Research Facility. The program structure is similar to that used for the validation of codes used in the safety analyses for CANDU power reactors. (author)

Gaining a Competitive Edge through Action Design Research

Science.gov (United States)

Alexa, L.; Alexa, M.; Avasilcăi, S.

2016-08-01

The current business environment is characterized by increased competition and highly innovative approach, in order to create products and services to better respond to the costumers’ needs and expectations. In this specific context, the research approaches need to be more flexible and business oriented and so, throughout the paper we have used a research method that combines design research and action research, named Action Design Research which is a research method used for generating prescriptive design knowledge through building and evaluating IT artifacts in an organizational setting [1]. Following the Action Design Research stages and principles: problem identification, building, intervention and evaluation, reflection and learning and formalization of learning, the research team has developed an online instrument used to actively involve the consumer in the product development process, in order to generate a better consumers insight regarding their needs and desires and to design and/or adjust the product accordingly. The customer engagement IT tool created and tested by using Action Design Research, E-PICUS, has been developed within the framework of the research project „E-solutions for innovation through customer pro-active involvement in value creation to increase organisational competitiveness (E-PICUS)”, PN- II-PT-PCCA-2013-4-1811, currently undergoing.

Innovative research reactor core designed. Estimation and analysis of gamma heating distribution

International Nuclear Information System (INIS)

Setiyanto

2014-01-01

The Gamma heating value is an important factor needed for safety analysis of each experiments that will be realized on research reactor core. Gamma heat is internal heat source occurs in each irradiation facilities or any material irradiated in reactor core. This value should be determined correctly because of the safety related problems. The gamma heating value is in general depend on. reactor core characteristics, different one and other, and then each new reactor design should be completed by gamma heating data. The Innovative Research Reactor is one of the new reactor design that should be completed with any safety data, including the gamma heating value. For this reasons, calculation and analysis of gamma heating in the hole of reactor core and irradiation facilities in reflector had been done by using of modified and validated Gamset computer code. The result shown that gamma heating value of 11.75 W/g is the highest value at the center of reactor core, higher than gamma heating value of RSG-GAS. However, placement of all irradiation facilities in reflector show that safety characteristics for irradiation facilities of innovative research reactor more better than RSG-GAS reactor. Regarding the results obtained, and based on placement of irradiation facilities in reflector, can be concluded that innovative research reactor more safe for any irradiation used. (author)

Depth of Field: Discursive design research through film

Directory of Open Access Journals (Sweden)

Timo Arnall

2010-07-01

Full Text Available This article is about the role of film in interaction and product design research with technology, and the use of film in exploring and explaining emerging technologies in multiple contexts. We have engaged in a reflective design research process that uses graphical, audiovisual, and time-based media as a tool, a material and a communicative artefact that enables us to approach complex, obscure and often invisible emerging technologies. We give a discursive account of how film has played an intricate role in our design research practice, from revealing the materiality of invisible wireless technology, to explaining complex technical prototypes, to communicating to a public audience through online films that may fold broader social and cultural discourses back into our design research process. We conclude by elaborating on discursive design approaches to research that use film as a reflective and communicative medium that allows for design research to operate within a social and cultural frame.

Quasi experimental designs in pharmacist intervention research.

Science.gov (United States)

Krass, Ines

2016-06-01

Background In the field of pharmacist intervention research it is often difficult to conform to the rigorous requirements of the "true experimental" models, especially the requirement of randomization. When randomization is not feasible, a practice based researcher can choose from a range of "quasi-experimental designs" i.e., non-randomised and at time non controlled. Objective The aim of this article was to provide an overview of quasi-experimental designs, discuss their strengths and weaknesses and to investigate their application in pharmacist intervention research over the previous decade. Results In the literature quasi experimental studies may be classified into five broad categories: quasi-experimental design without control groups; quasi-experimental design that use control groups with no pre-test; quasi-experimental design that use control groups and pre-tests; interrupted time series and stepped wedge designs. Quasi-experimental study design has consistently featured in the evolution of pharmacist intervention research. The most commonly applied of all quasi experimental designs in the practice based research literature are the one group pre-post-test design and the non-equivalent control group design i.e., (untreated control group with dependent pre-tests and post-tests) and have been used to test the impact of pharmacist interventions in general medications management as well as in specific disease states. Conclusion Quasi experimental studies have a role to play as proof of concept, in the pilot phases of interventions when testing different intervention components, especially in complex interventions. They serve to develop an understanding of possible intervention effects: while in isolation they yield weak evidence of clinical efficacy, taken collectively, they help build a body of evidence in support of the value of pharmacist interventions across different practice settings and countries. However, when a traditional RCT is not feasible for

Implementing Clinical Research Using Factorial Designs: A Primer.

Science.gov (United States)

Baker, Timothy B; Smith, Stevens S; Bolt, Daniel M; Loh, Wei-Yin; Mermelstein, Robin; Fiore, Michael C; Piper, Megan E; Collins, Linda M

2017-07-01

Factorial experiments have rarely been used in the development or evaluation of clinical interventions. However, factorial designs offer advantages over randomized controlled trial designs, the latter being much more frequently used in such research. Factorial designs are highly efficient (permitting evaluation of multiple intervention components with good statistical power) and present the opportunity to detect interactions amongst intervention components. Such advantages have led methodologists to advocate for the greater use of factorial designs in research on clinical interventions (Collins, Dziak, & Li, 2009). However, researchers considering the use of such designs in clinical research face a series of choices that have consequential implications for the interpretability and value of the experimental results. These choices include: whether to use a factorial design, selection of the number and type of factors to include, how to address the compatibility of the different factors included, whether and how to avoid confounds between the type and number of interventions a participant receives, and how to interpret interactions. The use of factorial designs in clinical intervention research poses choices that differ from those typically considered in randomized clinical trial designs. However, the great information yield of the former encourages clinical researchers' increased and careful execution of such designs. Copyright © 2017. Published by Elsevier Ltd.

Computer code validation study of PWR core design system, CASMO-3/MASTER-α

International Nuclear Information System (INIS)

Lee, K. H.; Kim, M. H.; Woo, S. W.

1999-01-01

In this paper, the feasibility of CASMO-3/MASTER-α nuclear design system was investigated for commercial PWR core. Validation calculation was performed as follows. Firstly, the accuracy of cross section generation from table set using linear feedback model was estimated. Secondly, the results of CASMO-3/MASTER-α was compared with CASMO-3/NESTLE 5.02 for a few benchmark problems. Microscopic cross sections computed from table set were almost the same with those from CASMO-3. There were small differences between calculated results of two code systems. Thirdly, the repetition of CASMO-3/MASTER-α calculation for Younggwang Unit-3, Cycle-1 core was done and their results were compared with nuclear design report(NDR) and uncertainty analysis results of KAERI. It was found that uncertainty analysis results were reliable enough because results were agreed each other. It was concluded that the use of nuclear design system CASMO-3/MASTER-α was validated for commercial PWR core

Making Theory Come Alive through Practice-based Design Research

DEFF Research Database (Denmark)

Markussen, Thomas; Knutz, Eva; Rind Christensen, Poul

The aim of this paper is to demonstrate how practice-based design research is able not only to challenge, but also to push toward further development of some of the basic assumpstions in emotion theories as used within design research. In so doing, we wish to increase knolwedge on a central...... epistemological question for design research, namely how practice-based design research can be a vehicle for the construction of new theory for design research....

Validity of the Mayer-Salovey-Caruso Emotional Intelligence Test: Youth Version-Research Edition

Science.gov (United States)

Peters, Christine; Kranzler, John H.; Rossen, Eric

2009-01-01

This study examines the criterion-related validity evidence of scores on the Mayer-Salovey-Caruso Emotional Intelligence Test: Youth Version-Research Version. The authors also investigate the relationship between scores on the MSCEIT-YV and chronological age. Results provide initial support for the construct validity of the MSCEIT-YV but also…

Artificial intelligence applications to design validation and sneak function analysis

International Nuclear Information System (INIS)

Stratton, R.C.

1985-01-01

An objective of the US space reactor program is to design systems with high reliability and safety of control over long operating lifetimes. Argonne National Laboratory (ANL) is a participant in the National Man-Machine Integration (MMI) program for Liquid Metal Fast Breeder Reactors (LMFBR). A purpose of this program is to promote the development of concepts and technologies that enhance the operational safety and reliability of fast-breeder reactors. Much of the work is directly applicable to the space reactor program. This paper reports on one of the MMI projects being developed by ANL. The project reported pertains to an automated system that demonstrates the use of artificial intelligence (AI) for design validation (DA) and sneak function analysis (SFA). The AI system models the design specification and the physical design of the cooling process assigned to the Argon Cooling System (ACS) at Experimental Breeder Reactor II (EBR-II). The models are developed using heuristic knowledge and natural laws. 13 refs

Design of a new research reactor : 1st year conceptual design

International Nuclear Information System (INIS)

Park, Cheol; Lee, B. C.; Chae, H. T.

2004-01-01

A new research reactor model satisfying the strengthened regulatory environments and the changed circumstances around nuclear society should be prepared for the domestic and international demand of research reactor. This can also lead to the improvement of technologies and fostering manpower obtained during the construction and the operation of HANARO. In this aspect, this study has been launched and the 1st year conceptual design has been carried out in 2003. The major tasks performed at the first year of conceptual design stage are as follows; Establishments of general design requirements of research reactors and experimental facilities, Establishment of fuel and reactor core concepts, Preliminary analysis of reactor physics and thermal-hydraulics for conceptual core, Conceptual design of reactor structure and major systems, International cooperation to establish foundations for exporting

Shielding design method for LMFBR validation on the Phenix factor

International Nuclear Information System (INIS)

Cabrillat, J.C.; Crouzet, J.; Misrakis, J.; Salvatores, M.; Rado, V.; Palmiotti, G.

1983-05-01

Shielding design methods, developed at CEA for shielding calculations find a global validation by the means of Phenix power reactor (250 MWe) measurements. Particularly, the secondary sodium activation of pool type LMFBR such as Super Phenix (1200 MWe) which is subject to strict safety limitation is well calculated by the adapted scheme, i.e. a two dimension transport calculation of shielding coupled to a Monte-Carlo calculation of secondary sodium activation

Design, Development, and Testing of a UAV Hardware-in-the-Loop Testbed for Aviation and Airspace Prognostics Research

Science.gov (United States)

Kulkarni, Chetan; Teubert, Chris; Gorospe, George; Burgett, Drew; Quach, Cuong C.; Hogge, Edward

2016-01-01

The airspace is becoming more and more complicated, and will continue to do so in the future with the integration of Unmanned Aerial Vehicles (UAVs), autonomy, spacecraft, other forms of aviation technology into the airspace. The new technology and complexity increases the importance and difficulty of safety assurance. Additionally, testing new technologies on complex aviation systems & systems of systems can be very difficult, expensive, and sometimes unsafe in real life scenarios. Prognostic methodology provides an estimate of the health and risks of a component, vehicle, or airspace and knowledge of how that will change over time. That measure is especially useful in safety determination, mission planning, and maintenance scheduling. The developed testbed will be used to validate prediction algorithms for the real-time safety monitoring of the National Airspace System (NAS) and the prediction of unsafe events. The framework injects flight related anomalies related to ground systems, routing, airport congestion, etc. to test and verify algorithms for NAS safety. In our research work, we develop a live, distributed, hardware-in-the-loop testbed for aviation and airspace prognostics along with exploring further research possibilities to verify and validate future algorithms for NAS safety. The testbed integrates virtual aircraft using the X-Plane simulator and X-PlaneConnect toolbox, UAVs using onboard sensors and cellular communications, and hardware in the loop components. In addition, the testbed includes an additional research framework to support and simplify future research activities. It enables safe, accurate, and inexpensive experimentation and research into airspace and vehicle prognosis that would not have been possible otherwise. This paper describes the design, development, and testing of this system. Software reliability, safety and latency are some of the critical design considerations in development of the testbed. Integration of HITL elements in

Leveraging Failure in Design Research

Science.gov (United States)

Lobato, Joanne; Walters, C. David; Hohensee, Charles; Gruver, John; Diamond, Jaime Marie

2015-01-01

Even in the resource-rich, more ideal conditions of many design-based classroom interventions, unexpected events can lead to disappointing results in student learning. However, if later iterations in a design research study are more successful, the previous failures can provide opportunities for comparisons to reveal subtle differences in…

Building a Cohesive Body of Design Knowledge: Developments from a Design Science Research Perspective

DEFF Research Database (Denmark)

Cash, Philip; Piirainen, Kalle A.

2015-01-01

researchers have identified difficulties in building on past works, and combining insights from across the field. This work starts to dissolve some of these issues by drawing on Design Science Research to propose an integrated approach for the development of design research knowledge, coupled with pragmatic......Design is an extremely diverse field where there has been widespread debate on how to build a cohesive body of scientific knowledge. To date, no satisfactory proposition has been adopted across the field – hampering scientific development. Without this basis for bringing research together design...... advice for design researchers. This delivers a number of implications for researchers as well as for the field as a whole....

Towards practical application of sensors for monitoring animal health; design and validation of a model to detect ketosis.

Science.gov (United States)

Steensels, Machteld; Maltz, Ephraim; Bahr, Claudia; Berckmans, Daniel; Antler, Aharon; Halachmi, Ilan

2017-05-01

The objective of this study was to design and validate a mathematical model to detect post-calving ketosis. The validation was conducted in four commercial dairy farms in Israel, on a total of 706 multiparous Holstein dairy cows: 203 cows clinically diagnosed with ketosis and 503 healthy cows. A logistic binary regression model was developed, where the dependent variable is categorical (healthy/diseased) and a set of explanatory variables were measured with existing commercial sensors: rumination duration, activity and milk yield of each individual cow. In a first validation step (within-farm), the model was calibrated on the database of each farm separately. Two thirds of the sick cows and an equal number of healthy cows were randomly selected for model validation. The remaining one third of the cows, which did not participate in the model validation, were used for model calibration. In order to overcome the random selection effect, this procedure was repeated 100 times. In a second (between-farms) validation step, the model was calibrated on one farm and validated on another farm. Within-farm accuracy, ranging from 74 to 79%, was higher than between-farm accuracy, ranging from 49 to 72%, in all farms. The within-farm sensitivities ranged from 78 to 90%, and specificities ranged from 71 to 74%. The between-farms sensitivities ranged from 65 to 95%. The developed model can be improved in future research, by employing other variables that can be added; or by exploring other models to achieve greater sensitivity and specificity.

Using a Design Science Perspective to Understand a Complex Design-Based Research Process

DEFF Research Database (Denmark)

Bækgaard, Lars

2012-01-01

The purpose of the paper is to demonstrate how a design science perspective can be used to describe and understand a set of related design-based research processes. We describe and analyze a case study in a manner that is inspired by design science. The case study involves the design of modeling......-based research processes. And we argue that a design science perspective may be useful for both researchers and practitioners....... tools and the redesign of an information service in a library. We use a set of guidelines from a design science perspective to organize the description and analysis of the case study. By doing this we demonstrate the usefulness of design science as an analytical tool for understanding related design...

Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments.

Directory of Open Access Journals (Sweden)

Valerie C Henderson

Full Text Available The vast majority of medical interventions introduced into clinical development prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed preclinical research. We conducted a systematic review of preclinical research guidelines and organized recommendations according to the type of validity threat (internal, construct, or external or programmatic research activity they primarily address.We searched MEDLINE, Google Scholar, Google, and the EQUATOR Network website for all preclinical guideline documents published up to April 9, 2013 that addressed the design and conduct of in vivo animal experiments aimed at supporting clinical translation. To be eligible, documents had to provide guidance on the design or execution of preclinical animal experiments and represent the aggregated consensus of four or more investigators. Data from included guidelines were independently extracted by two individuals for discrete recommendations on the design and implementation of preclinical efficacy studies. These recommendations were then organized according to the type of validity threat they addressed. A total of 2,029 citations were identified through our search strategy. From these, we identified 26 guidelines that met our eligibility criteria--most of which were directed at neurological or cerebrovascular drug development. Together, these guidelines offered 55 different recommendations. Some of the most common recommendations included performance of a power calculation to determine sample size, randomized treatment allocation, and characterization of disease phenotype in the animal model prior to experimentation.By identifying the most recurrent recommendations among preclinical guidelines, we provide a starting point for developing preclinical guidelines in other disease domains. We also provide a basis for the study and evaluation of preclinical research practice. Please see later in the article for the Editors' Summary.

Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments.

Science.gov (United States)

Henderson, Valerie C; Kimmelman, Jonathan; Fergusson, Dean; Grimshaw, Jeremy M; Hackam, Dan G

2013-01-01

The vast majority of medical interventions introduced into clinical development prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed preclinical research. We conducted a systematic review of preclinical research guidelines and organized recommendations according to the type of validity threat (internal, construct, or external) or programmatic research activity they primarily address. We searched MEDLINE, Google Scholar, Google, and the EQUATOR Network website for all preclinical guideline documents published up to April 9, 2013 that addressed the design and conduct of in vivo animal experiments aimed at supporting clinical translation. To be eligible, documents had to provide guidance on the design or execution of preclinical animal experiments and represent the aggregated consensus of four or more investigators. Data from included guidelines were independently extracted by two individuals for discrete recommendations on the design and implementation of preclinical efficacy studies. These recommendations were then organized according to the type of validity threat they addressed. A total of 2,029 citations were identified through our search strategy. From these, we identified 26 guidelines that met our eligibility criteria--most of which were directed at neurological or cerebrovascular drug development. Together, these guidelines offered 55 different recommendations. Some of the most common recommendations included performance of a power calculation to determine sample size, randomized treatment allocation, and characterization of disease phenotype in the animal model prior to experimentation. By identifying the most recurrent recommendations among preclinical guidelines, we provide a starting point for developing preclinical guidelines in other disease domains. We also provide a basis for the study and evaluation of preclinical research practice. Please see later in the article for the Editors' Summary.

Critical Issues in Research Design in Action Research in an SME Development Context

Science.gov (United States)

McGrath, Helen; O'Toole, Thomas

2012-01-01

Purpose: The main aim of this paper is to develop guidelines on the critical issues to consider in research design in an action research (AR) environment for SME network capability development. Design/methodology/approach: The issues in research design for AR studies are developed from the authors' experience in running learning sets but, in…

Design science research as research approach in doctoral studies

CSIR Research Space (South Africa)

Kotzé, P

2015-08-01

Full Text Available Since the use of design science research (DSR) gained momentum as a research approach in information systems (IS), the adoption of a DSR approach in postgraduate studies became more acceptable. This paper reflects on a study to investigate how a...

What is it that is being designed in design-based research and how does it qualify as research?

DEFF Research Database (Denmark)

Gundersen, Peter Bukovica; Jørnø, Rasmus Leth Vergmann

2015-01-01

This article performs a comparative reading across a selection of seminal articles on Design based research in order to draw out and clarify key concepts that frame the approach. The article is a contribution to the ongoing discussion of how Design Based Research is or becomes a rigorous science....

Validity of High School Physic Module With Character Values Using Process Skill Approach In STKIP PGRI West Sumatera

Science.gov (United States)

Anaperta, M.; Helendra, H.; Zulva, R.

2018-04-01

This study aims to describe the validity of physics module with Character Oriented Values Using Process Approach Skills at Dynamic Electrical Material in high school physics / MA and SMK. The type of research is development research. The module development model uses the development model proposed by Plomp which consists of (1) preliminary research phase, (2) the prototyping phase, and (3) assessment phase. In this research is done is initial investigation phase and designing. Data collecting technique to know validation is observation and questionnaire. In the initial investigative phase, curriculum analysis, student analysis, and concept analysis were conducted. In the design phase and the realization of module design for SMA / MA and SMK subjects in dynamic electrical materials. After that, the formative evaluation which include self evaluation, prototyping (expert reviews, one-to-one, and small group. At this stage validity is performed. This research data is obtained through the module validation sheet, which then generates a valid module.

Social Media Resources for Participative Design Research

OpenAIRE

Qaed, Fatema; Briggs, Jo; Cockton, Gilbert

2016-01-01

We present our experiences of novel value from online social media for Participative Design (PD) research. We describe how particular social media (e.g. Facebook, Pinterest, WhatsApp and Twitter) were used during a five-year project on learning space design by the researcher and interested teachers across all research phases (contextual review, user studies, PD action research). Social media were used to source and share comments, photographs and video documentation, supporting participation ...

Improving the Validity of Quantitative Measures in Applied Linguistics Research

Science.gov (United States)

Purpura, James E.; Brown, James Dean; Schoonen, Rob

2015-01-01

In empirical applied linguistics research it is essential that the key variables are operationalized in a valid and reliable way, and that the scores are treated appropriately, allowing for a proper testing of the hypotheses under investigation. The current article addresses several theoretical and practical issues regarding the use of measurement…

Literature research concerning alternative methods for validation of criticality calculation systems

International Nuclear Information System (INIS)

Behler, Matthias

2016-05-01

Beside radiochemical analysis of irradiated fuel and critical experiments, which has become a well-established basis for the validation of depletion code and criticality codes respectively, also results of oscillation experiments or the operating conditions of power reactor and research reactors can provide useful information for the validation of the above mentioned codes. Based on a literature review the potential of the utilization of oscillation experiment measurements for the validation of criticality codes is estimated. It is found that the reactivity measurements for actinides and fission products within the CERES program on the reactors DIMPLE (Winfrith, UK) and MINERVE (Cadarache, France) can give a valuable addition to the commonly used critical experiments for criticality code validation. However, there are approaches but yet no generally satisfactory solution for integrating the reactivity measurements in a quantitative bias determination for the neutron multiplication factor of typical application cases including irradiated spent fuel outside reactor cores, calculated using common criticality codes.

Recommended Research Directions for Improving the Validation of Complex Systems Models.

Energy Technology Data Exchange (ETDEWEB)

Vugrin, Eric D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Trucano, Timothy G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Swiler, Laura Painton [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Finley, Patrick D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Flanagan, Tatiana Paz [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Naugle, Asmeret Bier [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Tsao, Jeffrey Y. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Verzi, Stephen Joseph [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-02-01

Improved validation for models of complex systems has been a primary focus over the past year for the Resilience in Complex Systems Research Challenge. This document describes a set of research directions that are the result of distilling those ideas into three categories of research -- epistemic uncertainty, strong tests, and value of information. The content of this document can be used to transmit valuable information to future research activities, update the Resilience in Complex Systems Research Challenge's roadmap, inform the upcoming FY18 Laboratory Directed Research and Development (LDRD) call and research proposals, and facilitate collaborations between Sandia and external organizations. The recommended research directions can provide topics for collaborative research, development of proposals, workshops, and other opportunities.

Invited review: study design considerations for clinical research in veterinary radiology and radiation oncology.

Science.gov (United States)

Scrivani, Peter V; Erb, Hollis N

2013-01-01

High quality clinical research is essential for advancing knowledge in the areas of veterinary radiology and radiation oncology. Types of clinical research studies may include experimental studies, method-comparison studies, and patient-based studies. Experimental studies explore issues relative to pathophysiology, patient safety, and treatment efficacy. Method-comparison studies evaluate agreement between techniques or between observers. Patient-based studies investigate naturally acquired disease and focus on questions asked in clinical practice that relate to individuals or populations (e.g., risk, accuracy, or prognosis). Careful preplanning and study design are essential in order to achieve valid results. A key point to planning studies is ensuring that the design is tailored to the study objectives. Good design includes a comprehensive literature review, asking suitable questions, selecting the proper sample population, collecting the appropriate data, performing the correct statistical analyses, and drawing conclusions supported by the available evidence. Most study designs are classified by whether they are experimental or observational, longitudinal or cross-sectional, and prospective or retrospective. Additional features (e.g., controlled, randomized, or blinded) may be described that address bias. Two related challenging aspects of study design are defining an important research question and selecting an appropriate sample population. The sample population should represent the target population as much as possible. Furthermore, when comparing groups, it is important that the groups are as alike to each other as possible except for the variables of interest. Medical images are well suited for clinical research because imaging signs are categorical or numerical variables that might be predictors or outcomes of diseases or treatments. © 2013 Veterinary Radiology & Ultrasound.

FEDS : A Framework for Evaluation in Design Science Research

DEFF Research Database (Denmark)

Venable, John; Pries-Heje, Jan; Baskerville, Richard

2015-01-01

Evaluation of design artefacts and design theories is a key activity in Design Science Research (DSR), as it provides feedback for further development and (if done correctly) assures the rigour of the research. However, the extant DSR literature provides insufficient guidance on evaluation...... to enable Design Science Researchers to effectively design and incorporate evaluation activities into a DSR project that can achieve DSR goals and objectives. To address this research gap, this research paper develops, explicates, and provides evidence for the utility of a Framework for Evaluation in Design...... Science (FEDS) together with a process to guide design science researchers in developing a strategy for evaluating the artefacts they develop within a DSR project. A FEDS strategy considers why, when, how, and what to evaluate. FEDS includes a two-dimensional characterisation of DSR evaluation episodes...

The Design:Lab as platform in participatory design research

DEFF Research Database (Denmark)

Binder, Thomas; Brandt, Eva

2008-01-01

The notion of laboratory or simply 'lab' has become popular in recent years in areas outside science and technology development. Learning Labs, Innovation Labs, Usability Labs, Media and Communication Labs and even Art Labs designate institutions or fora dedicated to change and experimentation...... as others have frequently used other metaphors like workshop, studio or atelier in design research. In this article we will argue that the laboratory metaphor is particularly suitable and useful for the design:lab, and we will give examples of how we have worked with the design:lab as a platform...

When all children comprehend: increasing the external validity of narrative comprehension development research

Science.gov (United States)

Burris, Silas E.; Brown, Danielle D.

2014-01-01

Narratives, also called stories, can be found in conversations, children's play interactions, reading material, and television programs. From infancy to adulthood, narrative comprehension processes interpret events and inform our understanding of physical and social environments. These processes have been extensively studied to ascertain the multifaceted nature of narrative comprehension. From this research we know that three overlapping processes (i.e., knowledge integration, goal structure understanding, and causal inference generation) proposed by the constructionist paradigm are necessary for narrative comprehension, narrative comprehension has a predictive relationship with children's later reading performance, and comprehension processes are generalizable to other contexts. Much of the previous research has emphasized internal and predictive validity; thus, limiting the generalizability of previous findings. We are concerned these limitations may be excluding underrepresented populations from benefits and implications identified by early comprehension processes research. This review identifies gaps in extant literature regarding external validity and argues for increased emphasis on externally valid research. We highlight limited research on narrative comprehension processes in children from low-income and minority populations, and argue for changes in comprehension assessments. Specifically, we argue both on- and off-line assessments should be used across various narrative types (e.g., picture books, televised narratives) with traditionally underserved and underrepresented populations. We propose increasing the generalizability of narrative comprehension processes research can inform persistent reading achievement gaps, and have practical implications for how children learn from narratives. PMID:24659973

When All Children Comprehend: Increasing the External Validity of Narrative Comprehension Development Research

Directory of Open Access Journals (Sweden)

Silas E. Burris

2014-03-01

Full Text Available Narratives, also called stories, can be found in conversations, children’s play interactions, reading material, and television programs. From infancy to adulthood, narrative comprehension processes interpret events and inform our understanding of physical and social environments. These processes have been extensively studied to ascertain the multifaceted nature of narrative comprehension. From this research we know that three overlapping processes (i.e., knowledge integration, goal structure understanding, and causal inference generation proposed by the constructionist paradigm are necessary for narrative comprehension, narrative comprehension has a predictive relationship with children’s later reading performance, and comprehension processes are generalizable to other contexts. Much of the previous research has emphasized internal and predictive validity; thus, limiting the generalizability of previous findings. We are concerned these limitations may be excluding underrepresented populations from benefits and implications identified by early comprehension processes research. This review identifies gaps in extant literature regarding external validity and argues for increased emphasis on externally valid research. We highlight limited research on narrative comprehension processes in children from low-income and minority populations, and argue for changes in comprehension assessments. Specifically, we argue both on- and off-line assessments should be used across various narrative types (e.g., picture books, televised narratives with traditionally underserved and underrepresented populations. We propose increasing the generalizability narrative comprehension processes research can inform persistent reading achievement gaps, and have practical implications for how children learn from narratives.

Using Interdisciplinary and Active Research to Encourage Higher Resolution Research and Prototyping in Design

Directory of Open Access Journals (Sweden)

Adream Blair-Early

2014-10-01

Full Text Available University art and design programs are branching out and creating interdisciplinary programs and research centers that connect design students and faculty across various disciplines such as business, engineering, architecture, information studies, health sciences and education. A human-centered, problem-based approach to design research looks to position industry and academic leaders to work alongside students, community leaders, artists and non-profits to develop creative and innovative solutions to the challenges facing contemporary society. But product design benefits even more from practices that engage users throughout the entire design process, often called participatory design. Participatory design process utilizes user feedback throughout the design process to spur innovation and improve design quality. It is possible in the classroom to engage in participatory design and participatory prototyping through the use of inexpensive 3D printers and laser cutters as well as traditional hand tools, requiring only mastery of a few simple techniques and technology readily available on laptop computers. The class research being presented was conceived as part of a new interdisciplinary classroom research space call the Digital Craft Research Lab (DCRL housed within the department of Art and Design. Courses taught within the DCRL offer students, researchers and faculty continual access to both low resolution and high-resolution prototyping machinery and materials. This paper looks at the role of action and participatory research in a design course that created printed hand innovations in collaboration with a nine-year-old female user. Students were asked to work on modeling new designs as well as capturing the progress in a final open source book and models. This paper asks the question can the use of classroom collaboration, action research and work spaces encourage creativity, innovation, and critical thinking in student and professional

Design, Validation, and Use of an Evaluation Instrument for Monitoring Systemic Reform.

Science.gov (United States)

Scantlebury, Kathryn; Boone, William; Kahle, Jane Butler; Fraser, Barry J.

2001-01-01

Describes the design, development, validation, and use of an instrument that measures student attitudes and several environmental dimensions (i.e., standards-based teaching, home support, and peer support). Indicates that the classroom environment (standards-based teaching practices) was the strongest independent predictor of both achievement and…

Impacting Society through Engineering Design Research

DEFF Research Database (Denmark)

Howard, Thomas J.

2011-01-01

Following the recent ICED11 conference in Copenhagen, Thomas Howard, ICED11 Assistant Chair and Ass. Professor at DTU has written a reflection on design research and design practice, suggesting that in addition to benefiting society through the improved understanding of methods of and approaches...... to design, the academic design community should through design practice produce empowering products which address societal needs unbound by the necessity for profit....

Getting started in research: designing and preparing to conduct a research study.

Science.gov (United States)

Macfarlane, Matthew D; Kisely, Steve; Loi, Samantha; Macfarlane, Stephen; Merry, Sally; Parker, Stephen; Power, Brian; Siskind, Dan; Smith, Geoff; Looi, Jeffrey C

2015-02-01

To discuss common pitfalls and useful tips in designing a quantitative research study, the importance and process of ethical approval, and consideration of funding. Through careful planning, based on formulation of a research question, early career researchers can design and conduct quantitative research projects within the framework of the Scholarly Project or in their own independent projects. © The Royal Australian and New Zealand College of Psychiatrists 2014.

The Dynamic Similitude Design Method of Thin Walled Structures and Experimental Validation

Directory of Open Access Journals (Sweden)

Zhong Luo

2016-01-01

Full Text Available For the applicability of dynamic similitude models of thin walled structures, such as engine blades, turbine discs, and cylindrical shells, the dynamic similitude design of typical thin walled structures is investigated. The governing equation of typical thin walled structures is firstly unified, which guides to establishing dynamic scaling laws of typical thin walled structures. Based on the governing equation, geometrically complete scaling law of the typical thin walled structure is derived. In order to determine accurate distorted scaling laws of typical thin walled structures, three principles are proposed and theoretically proved by combining the sensitivity analysis and governing equation. Taking the thin walled annular plate as an example, geometrically complete and distorted scaling laws can be obtained based on the principles of determining dynamic scaling laws. Furthermore, the previous five orders’ accurate distorted scaling laws of thin walled annular plates are presented and numerically validated. Finally, the effectiveness of the similitude design method is validated by experimental annular plates.

Validation of the theoretical domains framework for use in behaviour change and implementation research

OpenAIRE

Cane, James E.; O'Connor, Denise; Michie, Susan

2012-01-01

Abstract Background An integrative theoretical framework, developed for cross-disciplinary implementation and other behaviour change research, has been applied across a wide range of clinical situations. This study tests the validity of this framework. Methods Validity was investigated by behavioural experts sorting 112 unique theoretical constructs using closed and open sort tasks. The extent of replication was tested by Discriminant Content Validation and Fuzzy Cluster Analysis. Results The...

The application of mixed methods designs to trauma research.

Science.gov (United States)

Creswell, John W; Zhang, Wanqing

2009-12-01

Despite the use of quantitative and qualitative data in trauma research and therapy, mixed methods studies in this field have not been analyzed to help researchers designing investigations. This discussion begins by reviewing four core characteristics of mixed methods research in the social and human sciences. Combining these characteristics, the authors focus on four select mixed methods designs that are applicable in trauma research. These designs are defined and their essential elements noted. Applying these designs to trauma research, a search was conducted to locate mixed methods trauma studies. From this search, one sample study was selected, and its characteristics of mixed methods procedures noted. Finally, drawing on other mixed methods designs available, several follow-up mixed methods studies were described for this sample study, enabling trauma researchers to view design options for applying mixed methods research in trauma investigations.

Critical Race Design: An Emerging Methodological Approach to Anti-Racist Design and Implementation Research

Science.gov (United States)

Khalil, Deena; Kier, Meredith

2017-01-01

This article is about introducing Critical Race Design (CRD), a research methodology that centers race and equity at the nucleus of educational opportunities by design. First, the authors define design-based implementation research (DBIR; Penuel, Fishman, Cheng, & Sabelli, 2011) as an equity-oriented education research methodology where…

Water Power Research | Water Power | NREL

Science.gov (United States)

Water Power Research Water Power Research NREL conducts water power research; develops design tools ; and evaluates, validates, and supports the demonstration of innovative water power technologies. Photo of a buoy designed around the oscillating water column principle wherein the turbine captures the

[Design and validation of a questionnaire for psychosocial nursing diagnosis in Primary Care].

Science.gov (United States)

Brito-Brito, Pedro Ruymán; Rodríguez-Álvarez, Cristobalina; Sierra-López, Antonio; Rodríguez-Gómez, José Ángel; Aguirre-Jaime, Armando

2012-01-01

To develop a valid, reliable and easy-to-use questionnaire for a psychosocial nursing diagnosis. The study was performed in two phases: first phase, questionnaire design and construction; second phase, validity and reliability tests. A bank of items was constructed using the NANDA classification as a theoretical framework. Each item was assigned a Likert scale or dichotomous response. The combination of responses to the items constituted the diagnostic rules to assign up to 28 labels. A group of experts carried out the validity test for content. Other validated scales were used as reference standards for the criterion validity tests. Forty-five nurses provided the questionnaire to the patients on three separate occasions over a period of three weeks, and the other validated scales only once to 188 randomly selected patients in Primary Care centres in Tenerife (Spain). Validity tests for construct confirmed the six dimensions of the questionnaire with 91% of total variance explained. Validity tests for criterion showed a specificity of 66%-100%, and showed high correlations with the reference scales when the questionnaire was assigning nursing diagnoses. Reliability tests showed agreement of 56%-91% (PQuestionnaire for Psychosocial Nursing Diagnosis was called CdePS, and included 61 items. The CdePS is a valid, reliable and easy-to-use tool in Primary Care centres to improve the assigning of a psychosocial nursing diagnosis. Copyright © 2011 Elsevier España, S.L. All rights reserved.

Mixed Methods Research Designs in Counseling Psychology

Science.gov (United States)

Hanson, William E.; Creswell, John W.; Clark, Vicki L. Plano; Petska, Kelly S.; Creswell, David J.

2005-01-01

With the increased popularity of qualitative research, researchers in counseling psychology are expanding their methodologies to include mixed methods designs. These designs involve the collection, analysis, and integration of quantitative and qualitative data in a single or multiphase study. This article presents an overview of mixed methods…

Design, Evaluation and Validation, and Analysis of a Five-Dimensional Leadership Questionnaire for a Project Leader in an International Scientific Research Environment

CERN Document Server

Wilfinger, Roman

2008-01-01

The basic goal of the study is to develop a five dimensional leadership questionnaire for a project leader in an international scientific research laboratory and to verify statistically the independency of the individual questions from each other to ensure low overlap in content and meaning by achieving low correlation coefficients. This leadership questionnaire is designed to examine the behavior, personality, and character attributes of a project or experiment team leader in an international scientific research laboratory as perceived by her/his team members during the planning, design, implementation, and execution of the project itself. The leadership questionnaire is applied to a sample of about 40 participants from different international scientific research laboratories. This sample should represent in age, rank, and profession the whole population of employees and team members currently working in different international scientific research laboratories dealing with physics, informatics, and engineeri...

Effort, symptom validity testing, performance validity testing and traumatic brain injury.

Science.gov (United States)

Bigler, Erin D

2014-01-01

To understand the neurocognitive effects of brain injury, valid neuropsychological test findings are paramount. This review examines the research on what has been referred to a symptom validity testing (SVT). Above a designated cut-score signifies a 'passing' SVT performance which is likely the best indicator of valid neuropsychological test findings. Likewise, substantially below cut-point performance that nears chance or is at chance signifies invalid test performance. Significantly below chance is the sine qua non neuropsychological indicator for malingering. However, the interpretative problems with SVT performance below the cut-point yet far above chance are substantial, as pointed out in this review. This intermediate, border-zone performance on SVT measures is where substantial interpretative challenges exist. Case studies are used to highlight the many areas where additional research is needed. Historical perspectives are reviewed along with the neurobiology of effort. Reasons why performance validity testing (PVT) may be better than the SVT term are reviewed. Advances in neuroimaging techniques may be key in better understanding the meaning of border zone SVT failure. The review demonstrates the problems with rigidity in interpretation with established cut-scores. A better understanding of how certain types of neurological, neuropsychiatric and/or even test conditions may affect SVT performance is needed.

Design and Validation of a Rubric to Assess the Use of American Psychological Association Style in scientific articles

Directory of Open Access Journals (Sweden)

Gladys Merma Molina

2017-01-01

Full Text Available In this study, the researchers will explore the process of designing and validating a rubric to evaluate the adaptation of scientific articles in the format of the American Psychological Association (APA. The rubric will evaluate certain aspects of the APA format that allow authors, editors, and evaluators to decide if the scientific article is coherent with these rules. Overall, the rubric will concentrate on General Aspects of the article and on the Citation System. To do this, 10 articles that were published within 2012-2016 and included in the Journal Citation Report will be analyzed using technical expertise. After doing 5 pilot studies, the results showed the validity and the reliability of the instrument. Furthermore, the process showed the evidence of the possibilities of the rubric to contribute to uniform criteria that can be used as a didactic tool in different scenarios.

Evaluation and validation of social and psychological markers in randomised trials of complex interventions in mental health: a methodological research programme.

Science.gov (United States)

Dunn, Graham; Emsley, Richard; Liu, Hanhua; Landau, Sabine; Green, Jonathan; White, Ian; Pickles, Andrew

2015-11-01

The development of the capability and capacity to evaluate the outcomes of trials of complex interventions is a key priority of the National Institute for Health Research (NIHR) and the Medical Research Council (MRC). The evaluation of complex treatment programmes for mental illness (e.g. cognitive-behavioural therapy for depression or psychosis) not only is a vital component of this research in its own right but also provides a well-established model for the evaluation of complex interventions in other clinical areas. In the context of efficacy and mechanism evaluation (EME) there is a particular need for robust methods for making valid causal inference in explanatory analyses of the mechanisms of treatment-induced change in clinical outcomes in randomised clinical trials. The key objective was to produce statistical methods to enable trial investigators to make valid causal inferences about the mechanisms of treatment-induced change in these clinical outcomes. The primary objective of this report is to disseminate this methodology, aiming specifically at trial practitioners. The three components of the research were (1) the extension of instrumental variable (IV) methods to latent growth curve models and growth mixture models for repeated-measures data; (2) the development of designs and regression methods for parallel trials; and (3) the evaluation of the sensitivity/robustness of findings to the assumptions necessary for model identifiability. We illustrate our methods with applications from psychological and psychosocial intervention trials, keeping the technical details to a minimum, leaving the reporting of the more theoretical and mathematically demanding results for publication in appropriate specialist journals. We show how to estimate treatment effects and introduce methods for EME. We explain the use of IV methods and principal stratification to evaluate the role of putative treatment effect mediators and therapeutic process measures. These results are

An assessment of the validity of inelastic design analysis methods by comparisons of predictions with test results

International Nuclear Information System (INIS)

Corum, J.M.; Clinard, J.A.; Sartory, W.K.

1976-01-01

The use of computer programs that employ relatively complex constitutive theories and analysis procedures to perform inelastic design calculations on fast reactor system components introduces questions of validation and acceptance of the analysis results. We may ask ourselves, ''How valid are the answers.'' These questions, in turn, involve the concepts of verification of computer programs as well as qualification of the computer programs and of the underlying constitutive theories and analysis procedures. This paper addresses the latter - the qualification of the analysis methods for inelastic design calculations. Some of the work underway in the United States to provide the necessary information to evaluate inelastic analysis methods and computer programs is described, and typical comparisons of analysis predictions with inelastic structural test results are presented. It is emphasized throughout that rather than asking ourselves how valid, or correct, are the analytical predictions, we might more properly question whether or not the combination of the predictions and the associated high-temperature design criteria leads to an acceptable level of structural integrity. It is believed that in this context the analysis predictions are generally valid, even though exact correlations between predictions and actual behavior are not obtained and cannot be expected. Final judgment, however, must be reserved for the design analyst in each specific case. (author)

Experimental validation of a new heterogeneous mechanical test design

Science.gov (United States)

Aquino, J.; Campos, A. Andrade; Souto, N.; Thuillier, S.

2018-05-01

Standard material parameters identification strategies generally use an extensive number of classical tests for collecting the required experimental data. However, a great effort has been made recently by the scientific and industrial communities to support this experimental database on heterogeneous tests. These tests can provide richer information on the material behavior allowing the identification of a more complete set of material parameters. This is a result of the recent development of full-field measurements techniques, like digital image correlation (DIC), that can capture the heterogeneous deformation fields on the specimen surface during the test. Recently, new specimen geometries were designed to enhance the richness of the strain field and capture supplementary strain states. The butterfly specimen is an example of these new geometries, designed through a numerical optimization procedure where an indicator capable of evaluating the heterogeneity and the richness of strain information. However, no experimental validation was yet performed. The aim of this work is to experimentally validate the heterogeneous butterfly mechanical test in the parameter identification framework. For this aim, DIC technique and a Finite Element Model Up-date inverse strategy are used together for the parameter identification of a DC04 steel, as well as the calculation of the indicator. The experimental tests are carried out in a universal testing machine with the ARAMIS measuring system to provide the strain states on the specimen surface. The identification strategy is accomplished with the data obtained from the experimental tests and the results are compared to a reference numerical solution.

[Design and Validation of a Questionnaire on Vaccination in Students of Health Sciences, Spain].

Science.gov (United States)

Fernández-Prada, María; Ramos-Martín, Pedro; Madroñal-Menéndez, Jaime; Martínez-Ortega, Carmen; González-Cabrera, Joaquín

2016-11-07

Immunization rates among medicine and nursing students -and among health professional in general- during hospital training are low. It is necessary to investigate the causes for these low immunization rates. The objective of this study was to design and validate a questionnaire for exploring the attitudes and behaviours of medicine and nursing students toward immunization of vaccine-preventable diseases. An instrument validation study. The sample included 646 nursing and medicine students at University of Oviedo, Spain. It was a non-ramdom sampling. After the content validation process, a 24-item questionnaire was designed to assess attitudes and behaviours/behavioural intentions. Reliability (ordinal alpha), internal validity (exploratory factor analysis by parellel analysis), ANOVA and mediational model tests were performed. Exploratory factor analysis yielded two factors which accounted for 48.8% of total variance. Ordinal alpha for the total score was 0.92. Differences were observed across academic years in the dimensions of attitudes (F5.447=3.728) and knowledge (F5.448=65.59), but not in behaviours/behavioural intentions (F5.461=1.680). Attitudes demonstrated to be a moderating variable of knowledge and attitudes/behavioural attitudes (Indirect effect B=0.15; SD=0.3; 95% CI:0.09-0.19). We developed a questionnaie based on sufficient evidence of reliability and internal validity. Scores on attitudes and knowledge increase with the academic year. Attitudes act as a moderating variable between knowledge and behaviours/behavioural intentions.

Design and Statistics in Quantitative Translation (Process) Research

DEFF Research Database (Denmark)

Balling, Laura Winther; Hvelplund, Kristian Tangsgaard

2015-01-01

Traditionally, translation research has been qualitative, but quantitative research is becoming increasingly important, especially in translation process research but also in other areas of translation studies. This poses problems to many translation scholars since this way of thinking...... is unfamiliar. In this article, we attempt to mitigate these problems by outlining our approach to good quantitative research, all the way from research questions and study design to data preparation and statistics. We concentrate especially on the nature of the variables involved, both in terms of their scale...... and their role in the design; this has implications for both design and choice of statistics. Although we focus on quantitative research, we also argue that such research should be supplemented with qualitative analyses and considerations of the translation product....

Containment design, performance criteria and research needs for advanced reactor designs

International Nuclear Information System (INIS)

Bagdi, G.; Ali, S.; Costello, J

2004-01-01

This paper points out some important shifts in the basic expectations in the performance requirements for containment structures and discusses the areas where the containment structure design requirements and acceptance criteria can be integrated with ultimate test based insights. Although there has not been any new reactor construction in the United States for over thirty years, several designs of evolutionary and advanced reactors have already been certified. Performance requirements for containment structures under design basis and severe accident conditions and explicit consideration of seismic margins have been used in the design certification process. In the United States, the containment structure design code is the American Society of Mechanical Engineers, Boiler and Pressure Vessel Code, Section III, Division 1, Subsection NE-Class MC for the steel containment and Section III, Division 2 for reinforced and prestressed concrete reactor vessels and containments. This containment design code was based on the early concept of applying design basis internal pressure and associated load combinations that included the operating basis and safe shutdown earthquake ground motion. These early design criteria served the nuclear industry and the regulatory authorities in maintaining public health and safety. However, these early design criteria do not incorporate the performance criteria related to containment function in an integrated fashion. Research in large scale model testing of containment structures to failure from over pressurization and shake table testing using simulated ground motion, have produced insights related to failure modes and material behavior at failure. The results of this research provide the opportunity to integrate these observations into design and acceptance criteria. This integration process would identify 'gaps' in the present knowledge and future research needs. This knowledge base is important for gleaning risk-informed insights into

VALIDATION OF SIMULATION MODELS FOR DIFFERENTLY DESIGNED HEAT-PIPE EVACUATED TUBULAR COLLECTORS

DEFF Research Database (Denmark)

Fan, Jianhua; Dragsted, Janne; Furbo, Simon

2007-01-01

Differently designed heat-pipe evacuated tubular collectors have been investigated theoretically and experimentally. The theoretical work has included development of two TRNSYS [1] simulation models for heat-pipe evacuated tubular collectors utilizing solar radiation from all directions. One model...... coating on both sides. The input to the models is thus not a simple collector efficiency expression but the actual collector geometry. In this study, the TRNSYS models are validated with measurements for four differently designed heat-pipe evacuated tubular collectors. The collectors are produced...

Designing and Assessing the Validity and Reliability of the Hospital Readiness Assessment Tools to Conducting Quality Improvement Program

Directory of Open Access Journals (Sweden)

Kamal Gholipoor

2016-09-01

Full Text Available Background and objectives : Identifying the readiness of hospital and its strengths and weaknesses can be useful in developing appropriate planning and situation analyses and management to getting effective in clinical audit programs. The aim of this study was to design and assess the validity of the Hospital Readiness Assessment Tools to conduct quality improvement and clinical audit programs. Material and Methods: In this study, based on the results of a systematic review of literature, an initial questionnaire with 77 items was designed. Questionnaire content validity was reviewed by experts in the field of hospital management and quality improvement in Tabriz University of Medical Sciences. For this purpose, 20 questionnaires were sent to experts. Finally, 15 participants returned completed questionnaire. Questionnaire validity was reviewed and confirmed based on Content Validity Index and Content Validity Ratio. Questionnaire reliability was confirmed based on Cronbach's alpha index (α = 0.96 in a pilot study by participation of 30 hospital managers. Results: The results showed that the final questionnaire contains 54 questions as nine category as: data and information (9 items, teamwork (12 questions, resources (5 questions, patient and education (5, intervention design and implementation (5 questions, clinical audit management (4 questions, human resources (6 questions, evidence and standard (4 items and evaluation and feedback (4 items. The final questionnaire content validity index was 0.91 and final questionnaire Cronbach's alpha coefficient was 0.96. Conclusion: Considering the relative good validity and reliability of the designed tool in this study, it appears that the questionnaire can be used to identify and assess the readiness of hospitals for quality improvement and clinical audit program implementation

Validation of scaffold design optimization in bone tissue engineering: finite element modeling versus designed experiments.

Science.gov (United States)

Uth, Nicholas; Mueller, Jens; Smucker, Byran; Yousefi, Azizeh-Mitra

2017-02-21

This study reports the development of biological/synthetic scaffolds for bone tissue engineering (TE) via 3D bioplotting. These scaffolds were composed of poly(L-lactic-co-glycolic acid) (PLGA), type I collagen, and nano-hydroxyapatite (nHA) in an attempt to mimic the extracellular matrix of bone. The solvent used for processing the scaffolds was 1,1,1,3,3,3-hexafluoro-2-propanol. The produced scaffolds were characterized by scanning electron microscopy, microcomputed tomography, thermogravimetric analysis, and unconfined compression test. This study also sought to validate the use of finite-element optimization in COMSOL Multiphysics for scaffold design. Scaffold topology was simplified to three factors: nHA content, strand diameter, and strand spacing. These factors affect the ability of the scaffold to bear mechanical loads and how porous the structure can be. Twenty four scaffolds were constructed according to an I-optimal, split-plot designed experiment (DE) in order to generate experimental models of the factor-response relationships. Within the design region, the DE and COMSOL models agreed in their recommended optimal nHA (30%) and strand diameter (460 μm). However, the two methods disagreed by more than 30% in strand spacing (908 μm for DE; 601 μm for COMSOL). Seven scaffolds were 3D-bioplotted to validate the predictions of DE and COMSOL models (4.5-9.9 MPa measured moduli). The predictions for these scaffolds showed relative agreement for scaffold porosity (mean absolute percentage error of 4% for DE and 13% for COMSOL), but were substantially poorer for scaffold modulus (51% for DE; 21% for COMSOL), partly due to some simplifying assumptions made by the models. Expanding the design region in future experiments (e.g., higher nHA content and strand diameter), developing an efficient solvent evaporation method, and exerting a greater control over layer overlap could allow developing PLGA-nHA-collagen scaffolds to meet the mechanical requirements for

Enhancing public involvement in assistive technology design research.

Science.gov (United States)

Williamson, Tracey; Kenney, Laurence; Barker, Anthony T; Cooper, Glen; Good, Tim; Healey, Jamie; Heller, Ben; Howard, David; Matthews, Martin; Prenton, Sarah; Ryan, Julia; Smith, Christine

2015-05-01

To appraise the application of accepted good practice guidance on public involvement in assistive technology research and to identify its impact on the research team, the public, device and trial design. Critical reflection and within-project evaluation were undertaken in a case study of the development of a functional electrical stimulation device. Individual and group interviews were undertaken with lay members of a 10 strong study user advisory group and also research team members. Public involvement was seen positively by research team members, who reported a positive impact on device and study designs. The public identified positive impact on confidence, skills, self-esteem, enjoyment, contribution to improving the care of others and opportunities for further involvement in research. A negative impact concerned the challenge of engaging the public in dissemination after the study end. The public were able to impact significantly on the design of an assistive technology device which was made more fit for purpose. Research team attitudes to public involvement were more positive after having witnessed its potential first hand. Within-project evaluation underpins this case study which presents a much needed detailed account of public involvement in assistive technology design research to add to the existing weak evidence base. The evidence base for impact of public involvement in rehabilitation technology design is in need of development. Public involvement in co-design of rehabilitation devices can lead to technologies that are fit for purpose. Rehabilitation researchers need to consider the merits of active public involvement in research.

Feed-pump hydraulic performance and design improvement, Phase I: research program design. Final report

Energy Technology Data Exchange (ETDEWEB)

Brown, W.H.; Gopalakrishnan, S.; Fehlau, R.; Thompson, W.E.; Wilson, D.G.

1982-03-01

As a result of prior EPRI-sponsored studies, it was concluded that a research program should be designed and implemented to provide an improved basis for the design, procurement, testing, and operation of large feed pumps with increased reliability and stability over the full range of operating conditions. This two-volume report contains a research plan which is based on a review of the present state of the art and which defines the necessary R and D program and estimates the benefits and costs of the program. The recommended research program consists of 30 interrelated tasks. It is designed to perform the needed research; to verify the results; to develop improved components; and to publish computer-aided design methods, pump specification guidelines, and a troubleshooting manual. Most of the technology proposed in the research plan is applicable to nuclear power plants as well as to fossil-fired plants. This volume discusses the design, performance and failures of feed pumps, and recommendations for research on pump dynamics, design, and specifications.

Review of research in feature based design

NARCIS (Netherlands)

Salomons, O.W.; van Houten, Frederikus J.A.M.; Kals, H.J.J.

1993-01-01

Research in feature-based design is reviewed. Feature-based design is regarded as a key factor towards CAD/CAPP integration from a process planning point of view. From a design point of view, feature-based design offers possibilities for supporting the design process better than current CAD systems

Design, validation and annotation of transcriptome-wide oligonucleotide probes for the oligochaete annelid Eisenia fetida.

Directory of Open Access Journals (Sweden)

Ping Gong

Full Text Available High density oligonucleotide probe arrays have increasingly become an important tool in genomics studies. In organisms with incomplete genome sequence, one strategy for oligo probe design is to reduce the number of unique probes that target every non-redundant transcript through bioinformatic analysis and experimental testing. Here we adopted this strategy in making oligo probes for the earthworm Eisenia fetida, a species for which we have sequenced transcriptome-scale expressed sequence tags (ESTs. Our objectives were to identify unique transcripts as targets, to select an optimal and non-redundant oligo probe for each of these target ESTs, and to annotate the selected target sequences. We developed a streamlined and easy-to-follow approach to the design, validation and annotation of species-specific array probes. Four 244K-formatted oligo arrays were designed using eArray and were hybridized to a pooled E. fetida cRNA sample. We identified 63,541 probes with unsaturated signal intensities consistently above the background level. Target transcripts of these probes were annotated using several sequence alignment algorithms. Significant hits were obtained for 37,439 (59% probed targets. We validated and made publicly available 63.5K oligo probes so the earthworm research community can use them to pursue ecological, toxicological, and other functional genomics questions. Our approach is efficient, cost-effective and robust because it (1 does not require a major genomics core facility; (2 allows new probes to be easily added and old probes modified or eliminated when new sequence information becomes available, (3 is not bioinformatics-intensive upfront but does provide opportunities for more in-depth annotation of biological functions for target genes; and (4 if desired, EST orthologs to the UniGene clusters of a reference genome can be identified and selected in order to improve the target gene specificity of designed probes. This approach is

Data-driven engineering design research: Opportunities using open data

DEFF Research Database (Denmark)

Parraguez Ruiz, Pedro; Maier, Anja

2017-01-01

the already available and continuously growing body of open data sources to create opportunities for research in Engineering Design. Insights are illustrated by an examination of two examples: a study of open source software repositories and an analysis of open business registries in the cleantech industry....... We conclude with a discussion about the limitations, challenges and risks of using open data in Engineering Design research and practice.......Engineering Design research relies on quantitative and qualitative data to describe design-related phenomena and prescribe improvements for design practice. Given data availability, privacy requirements and other constraints, most empirical data used in Engineering Design research can be described...

Virtual and remote control tower research, design, development and validation

CERN Document Server

2016-01-01

The interdisciplinary research and development work carried out in the last ten years which is presented in this book aimed at replacing the conventional airport control tower by a new “remote tower operation” work environment (RTO) which should enhance work efficiency and safety and reduce costs. This revolutionary human–system interface allows for remote aerodrome traffic control without a physical tower building and enables the establishment of remote airport traffic control centers (RTC) of which each may serve several airports from a central location.

Designing intervention in educational game research

DEFF Research Database (Denmark)

Sørensen, Birgitte Holm; Magnussen, Rikke

2010-01-01

of game technology in educational settings: the game Global Conflict: Latin America, which is a role-playing game, set in a 3D environment. In the game, students play a freelance journalist who has to investigate particular issues or conflicts in the Latin American region. The game is designed to teach......The international focus on the learning potential of games in recent years has led to a boost in both academic research interest and the development of game formats. Numerous educational computer games are available for today’s teachers, but the implementation of games in everyday teaching is often...... problematic. In this paper, we argue that the focus on designing and implementing game-based learning environments in educational settings implies a need to rethink methodological questions on how to apply and study educational designs. We review the methodological approaches of design-based research...

Designing intervention in educational game research

DEFF Research Database (Denmark)

Magnussen, Rikke; Sørensen, Birgitte Holm

2010-01-01

of game technology in educational settings: the game Global Conflict: Latin America, which is a role-playing game, set in a 3D environment. In the game, students play a freelance journalist who has to investigate particular issues or conflicts in the Latin American region. The game is designed to teach......The international focus on the learning potential of games in recent years has led to a boost in both academic research interest and the development of game formats. Numerous educational computer games are available for today's teachers, but the implementation of games in everyday teaching is often...... problematic. In this paper, we argue that the focus on designing and implementing game-based learning environments in educational settings implies a need to rethink methodological questions on how to apply and study educational designs. We review the methodological approaches of design-based research...

DESIGN AND VALIDATION OF A CARDIORESPIRATORY ...

African Journals Online (AJOL)

UJA

This study aimed to validate the 10x20m test for children aged 3 to 6 years in order ... obtained adequate parameters of reliability and validity in healthy children aged 3 ... and is a determinant of cardiovascular risk in preschool children (Bürgi et al., ... (Seca 222, Hamburg, Germany), and weight (kg) that was recorded with a ...

Intentional research design in implementation science: implications for the use of nomothetic and idiographic assessment.

Science.gov (United States)

Lyon, Aaron R; Connors, Elizabeth; Jensen-Doss, Amanda; Landes, Sara J; Lewis, Cara C; McLeod, Bryce D; Rutt, Christopher; Stanick, Cameo; Weiner, Bryan J

2017-09-01

The advancement of implementation science is dependent on identifying assessment strategies that can address implementation and clinical outcome variables in ways that are valid, relevant to stakeholders, and scalable. This paper presents a measurement agenda for implementation science that integrates the previously disparate assessment traditions of idiographic and nomothetic approaches. Although idiographic and nomothetic approaches are both used in implementation science, a review of the literature on this topic suggests that their selection can be indiscriminate, driven by convenience, and not explicitly tied to research study design. As a result, they are not typically combined deliberately or effectively. Thoughtful integration may simultaneously enhance both the rigor and relevance of assessments across multiple levels within health service systems. Background on nomothetic and idiographic assessment is provided as well as their potential to support research in implementation science. Drawing from an existing framework, seven structures (of various sequencing and weighting options) and five functions (Convergence, Complementarity, Expansion, Development, Sampling) for integrating conceptually distinct research methods are articulated as they apply to the deliberate, design-driven integration of nomothetic and idiographic assessment approaches. Specific examples and practical guidance are provided to inform research consistent with this framework. Selection and integration of idiographic and nomothetic assessments for implementation science research designs can be improved. The current paper argues for the deliberate application of a clear framework to improve the rigor and relevance of contemporary assessment strategies.

Visual Servoing Tracking Control of a Ball and Plate System: Design, Implementation and Experimental Validation

Directory of Open Access Journals (Sweden)

Ming-Tzu Ho

2013-07-01

Full Text Available This paper presents the design, implementation and validation of real-time visual servoing tracking control for a ball and plate system. The position of the ball is measured with a machine vision system. The image processing algorithms of the machine vision system are pipelined and implemented on a field programmable gate array (FPGA device to meet real-time constraints. A detailed dynamic model of the system is derived for the simulation study. By neglecting the high-order coupling terms, the ball and plate system model is simplified into two decoupled ball and beam systems, and an approximate input-output feedback linearization approach is then used to design the controller for trajectory tracking. The designed control law is implemented on a digital signal processor (DSP. The validity of the performance of the developed control system is investigated through simulation and experimental studies. Experimental results show that the designed system functions well with reasonable agreement with simulations.

Mediation designs for tobacco prevention research

Science.gov (United States)

MacKinnon, David P.; Taborga, Marcia P.; Morgan-Lopez, Antonio A.

2010-01-01

This paper describes research designs and statistical analyses to investigate how tobacco prevention programs achieve their effects on tobacco use. A theoretical approach to program development and evaluation useful for any prevention program guides the analysis. The theoretical approach focuses on action theory for how the program affects mediating variables and on conceptual theory for how mediating variables are related to tobacco use. Information on the mediating mechanisms by which tobacco prevention programs achieve effects is useful for the development of efficient programs and provides a test of the theoretical basis of prevention efforts. Examples of these potential mediating mechanisms are described including mediated effects through attitudes, social norms, beliefs about positive consequences, and accessibility to tobacco. Prior research provides evidence that changes in social norms are a critical mediating mechanism for successful tobacco prevention. Analysis of mediating variables in single group designs with multiple mediators are described as well as multiple group randomized designs which are the most likely to accurately uncover important mediating mechanisms. More complicated dismantling and constructive designs are described and illustrated based on current findings from tobacco research. Mediation analysis for categorical outcomes and more complicated statistical methods are outlined. PMID:12324176

Development and validation of SEER (Seeking, Engaging with and Evaluating Research): a measure of policymakers' capacity to engage with and use research.

Science.gov (United States)

Brennan, Sue E; McKenzie, Joanne E; Turner, Tari; Redman, Sally; Makkar, Steve; Williamson, Anna; Haynes, Abby; Green, Sally E

2017-01-17

Capacity building strategies are widely used to increase the use of research in policy development. However, a lack of well-validated measures for policy contexts has hampered efforts to identify priorities for capacity building and to evaluate the impact of strategies. We aimed to address this gap by developing SEER (Seeking, Engaging with and Evaluating Research), a self-report measure of individual policymakers' capacity to engage with and use research. We used the SPIRIT Action Framework to identify pertinent domains and guide development of items for measuring each domain. Scales covered (1) individual capacity to use research (confidence in using research, value placed on research, individual perceptions of the value their organisation places on research, supporting tools and systems), (2) actions taken to engage with research and researchers, and (3) use of research to inform policy (extent and type of research use). A sample of policymakers engaged in health policy development provided data to examine scale reliability (internal consistency, test-retest) and validity (relation to measures of similar concepts, relation to a measure of intention to use research, internal structure of the individual capacity scales). Response rates were 55% (150/272 people, 12 agencies) for the validity and internal consistency analyses, and 54% (57/105 people, 9 agencies) for test-retest reliability. The individual capacity scales demonstrated adequate internal consistency reliability (alpha coefficients > 0.7, all four scales) and test-retest reliability (intra-class correlation coefficients > 0.7 for three scales and 0.59 for fourth scale). Scores on individual capacity scales converged as predicted with measures of similar concepts (moderate correlations of > 0.4), and confirmatory factor analysis provided evidence that the scales measured related but distinct concepts. Items in each of these four scales related as predicted to concepts in the measurement model derived

DESIGN AND VALIDATION OF AN INTERORGANIZATIONAL INFORMATION SYSTEM

Directory of Open Access Journals (Sweden)

Kamel Rouibah

2006-01-01

Full Text Available This paper presents an interorganizational information system that aims to structure collaboration of engineering activities as well as data sharing across company borders. The paper also describes the approach underlying the system, validates it by designing a system prototype, and tests the system using questionnaire and in-depth interviews in order to further knowledge about the subject. The main results from the test show: collaboration engineering is potentially important for senior managers; end-users were specifically attracted more by the concept rather by its implementation; engineering change management is a complex process; and the support of strategic level is a critical success factor. In addition, the paper describes other factors that emerged during the ongoing project and inhibit success of the system.

Queering Participatory Design Research

Science.gov (United States)

McWilliams, Jacob

2016-01-01

This article offers a way forward for educators and researchers interested in drawing on the principles of "queer theory" to inform participatory design. In this article, I aim to achieve two related goals: To introduce new concepts within a critical conceptual practice of questioning and challenging the "heterosexual matrix"…

Understandings of the Concept of Iteration in Design-Based Research

DEFF Research Database (Denmark)

Gundersen, Peter Bukovica

2017-01-01

The paper is the first in a series of papers addressing design in Design-based research. The series looks into the question of how this research approach is connected to design. What happens when educational researchers adopt designerly ways of working? This paper provides an overview of design......-based research and from there on discuss one key characteristic, namely iterations, which are fundamental to educational design research in relation to how designers operate and why. The paper concludes that in general iteration is not a particularly well-described aspect in the reporting of DBR-projects. Half...... and usually after long periods of testing design solutions in practice....

Utilization of MCNP code in the research and design for China advanced research reactor

International Nuclear Information System (INIS)

Shen Feng

2006-01-01

MCNP, which is the internationalized neutronics code, is used for nuclear research and design in China Advanced Research Reactor (CARR). MCNP is an important neutronics code in the research and design for CARR since many calculation tasks could be undertaken by it. Many nuclear parameters on reactor core, the design and optimization research for many reactor utilizations, much verification for other nuclear calculation code and so on are conducted with help of MCNP. (author)

[Construction and validation of the "La Salle Instrument" to evaluate the ethical aspects in biomedical research on human beings].

Science.gov (United States)

Valdivia-Gómez, Gilberto Guzmán; Velasco-Jiménez, María Teresa; Domínguez-González, Alejandro; Meneses-Ruíz, Dulce María; Padilla-García, Raúl Amauri

2017-01-01

Research projects must demonstrate not only a rigorous scientific methodology, but also the ethical aspects that require profound reflection of the reviewers. Current regulations establish criteria for research projects on human health, but many of these aspects are subjective. How can the evaluation of such projects be standardized? This is the main subject of the current project. This project comprises two phases. First, the design and construction of an instrument of evaluation based on the fundamental principles of bioethics, which are autonomy, beneficence, non-maleficence, and justice, and other aspects. The second phase consists of content validation through expert. During the phase of reviewing the instrument, it was necessary to make changes by adding, removing, or changing the concepts or criteria, which lead to the construction of the second version of the format. This new instrument was reviewed and analyzed by using the AGREE II instrument, and this version was validated by experts by greater than 95%. There are some recommendations to analyze the ethical aspects in research protocols involving human subjects, but they define the concepts and criteria to be evaluated. By presenting the criteria to be evaluated individually, the "La Salle instrument" allows the evaluation to be more objective and standardized.

Validation of the Nuclear Design Method for MOX Fuel Loaded LWR Cores

International Nuclear Information System (INIS)

Saji, E.; Inoue, Y.; Mori, M.; Ushio, T.

2001-01-01

The actual batch loading of mixed-oxide (MOX) fuel in light water reactors (LWRs) is now ready to start in Japan. One of the efforts that have been devoted to realizing this batch loading has been validation of the nuclear design methods calculating the MOX-fuel-loaded LWR core characteristics. This paper summarizes the validation work for the applicability of the CASMO-4/SIMULATE-3 in-core fuel management code system to MOX-fuel-loaded LWR cores. This code system is widely used by a number of electric power companies for the core management of their commercial LWRs. The validation work was performed for both boiling water reactor (BWR) and pressurized water reactor (PWR) applications. Each validation consists of two parts: analyses of critical experiments and core tracking calculations of operating plants. For the critical experiments, we have chosen a series of experiments known as the VENUS International Program (VIP), which was performed at the SCK/CEN MOL laboratory in Belgium. VIP consists of both BWR and PWR fuel assembly configurations. As for the core tracking calculations, the operating data of MOX-fuel-loaded BWR and PWR cores in Europe have been utilized

Reconceptualizing Design Research in the Age of Mobile Learning

Science.gov (United States)

Bannan, Brenda; Cook, John; Pachler, Norbert

2016-01-01

The purpose of this paper is to begin to examine how the intersection of mobile learning and design research prompts the reconceptualization of research and design individually as well as their integration appropriate for current, complex learning environments. To fully conceptualize and reconceptualize design research in mobile learning, the…

Interpretation of custom designed Illumina genotype cluster plots for targeted association studies and next-generation sequence validation

Directory of Open Access Journals (Sweden)

Tindall Elizabeth A

2010-02-01

Full Text Available Abstract Background High-throughput custom designed genotyping arrays are a valuable resource for biologically focused research studies and increasingly for validation of variation predicted by next-generation sequencing (NGS technologies. We investigate the Illumina GoldenGate chemistry using custom designed VeraCode and sentrix array matrix (SAM assays for each of these applications, respectively. We highlight applications for interpretation of Illumina generated genotype cluster plots to maximise data inclusion and reduce genotyping errors. Findings We illustrate the dramatic effect of outliers in genotype calling and data interpretation, as well as suggest simple means to avoid genotyping errors. Furthermore we present this platform as a successful method for two-cluster rare or non-autosomal variant calling. The success of high-throughput technologies to accurately call rare variants will become an essential feature for future association studies. Finally, we highlight additional advantages of the Illumina GoldenGate chemistry in generating unusually segregated cluster plots that identify potential NGS generated sequencing error resulting from minimal coverage. Conclusions We demonstrate the importance of visually inspecting genotype cluster plots generated by the Illumina software and issue warnings regarding commonly accepted quality control parameters. In addition to suggesting applications to minimise data exclusion, we propose that the Illumina cluster plots may be helpful in identifying potential in-put sequence errors, particularly important for studies to validate NGS generated variation.

Design and validation of a critical pathway for hospital management of patients with severe traumatic brain injury.

Science.gov (United States)

Espinosa-Aguilar, Amilcar; Reyes-Morales, Hortensia; Huerta-Posada, Carlos E; de León, Itzcoatl Limón-Pérez; López-López, Fernando; Mejía-Hernández, Margarita; Mondragón-Martínez, María A; Calderón-Téllez, Ligia M; Amezcua-Cuevas, Rosa L; Rebollar-González, Jorge A

2008-05-01

Critical pathways for the management of patients with severe traumatic brain injury (STBI) may contribute to reducing the incidence of hospital complications, length of hospitalization stay, and cost of care. Such pathways have previously been developed for departments with significant resource availability. In Mexico, STBI is the most important cause of complications and length of stay in neurotrauma services at public hospitals. Although current treatment is designed basically in accordance with the Brain Trauma Foundation guidelines, shortfalls in the availability of local resources make it difficult to comply with these standards, and no critical pathway is available that accords with the resources of public hospitals. The purpose of the present study was to design and to validate a critical pathway for managing STBI patients that would be suitable for implementation in neurotrauma departments of middle-income level countries. The study comprised two phases: design (through literature review and design plan) and validation (content, construct, and appearance) of the critical pathway. The validated critical pathway for managing STBI patients entails four sequential subprocesses summarizing the hospital's care procedures, and includes three components: (1) nodes and criteria (in some cases, indicators are also included); (2) health team members in charge of the patient; (3) maximum estimated time for compliance with recommendations. This validated critical pathway is based on the current scientific evidence and accords with the availability of resources of middle-income countries.

Advanced Subsonic Technology (AST) 22-Inch Low Noise Research Fan Rig Preliminary Design of ADP-Type Fan 3

Science.gov (United States)

Jeracki, Robert J. (Technical Monitor); Topol, David A.; Ingram, Clint L.; Larkin, Michael J.; Roche, Charles H.; Thulin, Robert D.

2004-01-01

This report presents results of the work completed on the preliminary design of Fan 3 of NASA s 22-inch Fan Low Noise Research project. Fan 3 was intended to build on the experience gained from Fans 1 and 2 by demonstrating noise reduction technology that surpasses 1992 levels by 6 dB. The work was performed as part of NASA s Advanced Subsonic Technology (AST) program. Work on this task was conducted in the areas of CFD code validation, acoustic prediction and validation, rotor parametric studies, and fan exit guide vane (FEGV) studies up to the time when a NASA decision was made to cancel the design, fabrication and testing phases of the work. The scope of the program changed accordingly to concentrate on two subtasks: (1) Rig data analysis and CFD code validation and (2) Fan and FEGV optimization studies. The results of the CFD code validation work showed that this tool predicts 3D flowfield features well from the blade trailing edge to about a chord downstream. The CFD tool loses accuracy as the distance from the trailing edge increases beyond a blade chord. The comparisons of noise predictions to rig test data showed that both the tone noise tool and the broadband noise tool demonstrated reasonable agreement with the data to the degree that these tools can reliably be used for design work. The section on rig airflow and inlet separation analysis describes the method used to determine total fan airflow, shows the good agreement of predicted boundary layer profiles to measured profiles, and shows separation angles of attack ranging from 29.5 to 27deg for the range of airflows tested. The results of the rotor parametric studies were significant in leading to the decision not to pursue a new rotor design for Fan 3 and resulted in recommendations to concentrate efforts on FEGV stator designs. The ensuing parametric study on FEGV designs showed the potential for 8 to 10 EPNdB noise reduction relative to the baseline.

The TALL-3D facility design and commissioning tests for validation of coupled STH and CFD codes

Energy Technology Data Exchange (ETDEWEB)

Grishchenko, Dmitry, E-mail: dmitry@safety.sci.kth.se; Jeltsov, Marti, E-mail: marti@safety.sci.kth.se; Kööp, Kaspar, E-mail: kaspar@safety.sci.kth.se; Karbojian, Aram, E-mail: karbojan@kth.se; Villanueva, Walter, E-mail: walter@safety.sci.kth.se; Kudinov, Pavel, E-mail: pavel@safety.sci.kth.se

2015-08-15

Highlights: • Design of a heavy liquid thermal-hydraulic loop for CFD/STH code validation. • Description of the loop instrumentation and assessment of measurement error. • Experimental data from forced to natural circulation transient. - Abstract: Application of coupled CFD (Computational Fluid Dynamics) and STH (System Thermal Hydraulics) codes is a prerequisite for computationally affordable and sufficiently accurate prediction of thermal-hydraulics of complex systems. Coupled STH and CFD codes require validation for understanding and quantification of the sources of uncertainties in the code prediction. TALL-3D is a liquid Lead Bismuth Eutectic (LBE) loop developed according to the requirements for the experimental data for validation of coupled STH and CFD codes. The goals of the facility design are to provide (i) mutual feedback between natural circulation in the loop and complex 3D mixing and stratification phenomena in the pool-type test section, (ii) a possibility to validate standalone STH and CFD codes for each subsection of the facility, and (iii) sufficient number of experimental data to separate the process of input model calibration and code validation. Description of the facility design and its main components, approach to estimation of experimental uncertainty and calibration of model input parameters that are not directly measured in the experiment are discussed in the paper. First experimental data from the forced to natural circulation transient is also provided in the paper.

Design of JT-60SA magnets and associated experimental validations

International Nuclear Information System (INIS)

Zani, L.; Barabaschi, P.; Peyrot, M.; Meunier, L.; Tomarchio, V.; Duglue, D.; Decool, P.; Torre, A.; Marechal, J.L.; Della Corte, A.; Di Zenobio, A.; Muzzi, L.; Cucchiaro, A.; Turtu, S.; Ishida, S.; Yoshida, K.; Tsuchiya, K.; Kizu, K.; Murakami, H.

2011-01-01

In the framework of the JT-60SA project, aiming at upgrading the present JT-60U tokamak toward a fully superconducting configuration, the detailed design phase led to adopt for the three main magnet systems a brand new design. Europe (EU) is expected to provide to Japan (JA) the totality of the toroidal field (TF) magnet system, while JA will provide both Equilibrium field (EF) and Central Solenoid (CS) systems. All magnet designs were optimized trough the past years and entered in parallel into extensive experimentally-based phases of concept validation, which came to maturation in the years 2009 and 2010. For this, all magnet systems were investigated by mean of dedicated samples, e.g. conductor and joint samples designed, manufactured and tested at full scale in ad hoc facilities either in EU or in JA. The present paper, after an overall description of magnet systems layouts, presents in a general approach the different experimental campaigns dedicated to qualification design and manufacture processes of either coils, conductors and electrical joints. The main results with the associated analyses are shown and the main conclusions presented, especially regarding their contribution to consolidate the triggering of magnet mass production. The status of respective manufacturing stages in EU and in JA are also evoked. (authors)

Research in Architecture & Design, Aalborg University 2009-2012

DEFF Research Database (Denmark)

Publication, presenting the research at Architecture & Design, Department of Architecture & Mediea Technology 2009-2012. Editor Gitte Marling......Publication, presenting the research at Architecture & Design, Department of Architecture & Mediea Technology 2009-2012. Editor Gitte Marling...

Validity of the rey visual design test in primary and secondary school children

NARCIS (Netherlands)

Wilhelm, P.; van Klink, M.; van Klink, M.

2007-01-01

The Rey Visual Design Learning Test (Rey, 1964, cited in Spreen & Strauss, 1991, Wilhelm, 2004) assesses immediate memory span, new learning, delayed recall and recognition for nonverbal material. Two studies are presented that focused on the construct validity of the RVDLT in primary and secondary

Development of an ICT in IBSE course for science teachers: A design-based research

Science.gov (United States)

Tran, Trinh-Ba

2018-01-01

core of the basic design of the ICT in IBSE course. These principles can be considered as independent, validated educational products, which teacher educators can "buy into" and use for broader aims than only "ICT in IBSE" integration. Pedagogical principles establish the theoretical model underlying the course design, provide guidelines and structure to the (re)design, implementation, evaluation, and optimization process, and help to communicate the design-based research to others. The role of pedagogical principles in design-based research is indeed essential. Moreover, we incorporated a robustness test and a generalizability/transferability test as a further step in our design-based research and achieved successful outcomes with this step. Consequently, we strongly recommend the testing of the design product in routine implementation conditions and in considerably different contexts (e.g. different programmes or even countries) as part of design-based research.

Action Design Research for Social Innovation: Lessons from Designing a Health and Wellbeing Platform

NARCIS (Netherlands)

de Reuver, G.A.; Keijzer-Broers, W.J.W.

2016-01-01

IT artifacts play an important role in solving societal problems and realizing social innovations. Existing practice-inspired design science research (DSR) approaches, such as Action Design Research (ADR), do not consider social innovation as an explicit starting point for design iterations. In this

Research design and statistical methods in Indian medical journals: a retrospective survey.

Science.gov (United States)

Hassan, Shabbeer; Yellur, Rajashree; Subramani, Pooventhan; Adiga, Poornima; Gokhale, Manoj; Iyer, Manasa S; Mayya, Shreemathi S

2015-01-01

Good quality medical research generally requires not only an expertise in the chosen medical field of interest but also a sound knowledge of statistical methodology. The number of medical research articles which have been published in Indian medical journals has increased quite substantially in the past decade. The aim of this study was to collate all evidence on study design quality and statistical analyses used in selected leading Indian medical journals. Ten (10) leading Indian medical journals were selected based on impact factors and all original research articles published in 2003 (N = 588) and 2013 (N = 774) were categorized and reviewed. A validated checklist on study design, statistical analyses, results presentation, and interpretation was used for review and evaluation of the articles. Main outcomes considered in the present study were - study design types and their frequencies, error/defects proportion in study design, statistical analyses, and implementation of CONSORT checklist in RCT (randomized clinical trials). From 2003 to 2013: The proportion of erroneous statistical analyses did not decrease (χ2=0.592, Φ=0.027, p=0.4418), 25% (80/320) in 2003 compared to 22.6% (111/490) in 2013. Compared with 2003, significant improvement was seen in 2013; the proportion of papers using statistical tests increased significantly (χ2=26.96, Φ=0.16, pdesign decreased significantly (χ2=16.783, Φ=0.12 pdesigns has remained very low (7.3%, 43/588) with majority showing some errors (41 papers, 95.3%). Majority of the published studies were retrospective in nature both in 2003 [79.1% (465/588)] and in 2013 [78.2% (605/774)]. Major decreases in error proportions were observed in both results presentation (χ2=24.477, Φ=0.17, presearch seems to have made no major progress regarding using correct statistical analyses, but error/defects in study designs have decreased significantly. Randomized clinical trials are quite rarely published and have high proportion of

Validation and application of help code used for design and review of cover of low and intermediate level radioactive waste disposal in near-surface facilities

International Nuclear Information System (INIS)

Fan Zhiwen; Gu Cunli; Zhang Jinsheng; Liu Xiuzhen

1996-01-01

The authors describes validation and application of HELP code used by the United States Environmental Protective Agency for design and review of cover of low and intermediate level radioactive waste disposal in near-surface facilities. The HELP code was validated using data of field aerated moisture movement test by China Institute for Radiation Protection. The results show that simulation of HELP code is reasonable. Effects of surface layer thickness and surface treatment on moisture distribution in a cover was simulated with HELP code in the conditions of south-west China. The simulation results demonstrated that surface plantation of a cover plays very important role in moisture distribution in the cover. Special attention should be paid in cover design. In humid area, radioactive waste disposal safety should take full consideration with functions of chemical barrier. It was recommended that engineering economy should be added in future cover research so as to achieve optimization of cover design

Development of a Conservative Model Validation Approach for Reliable Analysis

Science.gov (United States)

2015-01-01

CIE 2015 August 2-5, 2015, Boston, Massachusetts, USA [DRAFT] DETC2015-46982 DEVELOPMENT OF A CONSERVATIVE MODEL VALIDATION APPROACH FOR RELIABLE...obtain a conservative simulation model for reliable design even with limited experimental data. Very little research has taken into account the...3, the proposed conservative model validation is briefly compared to the conventional model validation approach. Section 4 describes how to account

Research Design in the study of the European Neighbourhood Policy

DEFF Research Database (Denmark)

Exadaktylos, Theofanis; Lynggaard, Kennet

2017-01-01

This chapter deals with the pitfalls and pathways of research design aimed at the study of the European Neighbourhood Policy (ENP) and maps out the literature on questions of knowledge ambition, research ontology and epistemology, and choices of approaches to the research object. We include...... a review of traditional research designs in ENP research, through a systematic meta-analysis of a selection of the most-cited articles on the ENP. Inspired by earlier work on awareness of research design in EU studies, ENP research is categorised according to typical choices of research design in the form...... of dichotomous trade-offs. The chapter then discusses how individual contributions to this volume deal with research design challenges of the past and present innovative ways of studying the revised ENP....

NASA Space Engineering Research Center for VLSI systems design

Science.gov (United States)

1991-01-01

This annual review reports the center's activities and findings on very large scale integration (VLSI) systems design for 1990, including project status, financial support, publications, the NASA Space Engineering Research Center (SERC) Symposium on VLSI Design, research results, and outreach programs. Processor chips completed or under development are listed. Research results summarized include a design technique to harden complementary metal oxide semiconductors (CMOS) memory circuits against single event upset (SEU); improved circuit design procedures; and advances in computer aided design (CAD), communications, computer architectures, and reliability design. Also described is a high school teacher program that exposes teachers to the fundamentals of digital logic design.

Improving validity of informed consent for biomedical research in Zambia using a laboratory exposure intervention.

Science.gov (United States)

Zulu, Joseph Mumba; Lisulo, Mpala Mwanza; Besa, Ellen; Kaonga, Patrick; Chisenga, Caroline C; Chomba, Mumba; Simuyandi, Michelo; Banda, Rosemary; Kelly, Paul

2014-01-01

Complex biomedical research can lead to disquiet in communities with limited exposure to scientific discussions, leading to rumours or to high drop-out rates. We set out to test an intervention designed to address apprehensions commonly encountered in a community where literacy is uncommon, and where complex biomedical research has been conducted for over a decade. We aimed to determine if it could improve the validity of consent. Data were collected using focus group discussions, key informant interviews and observations. We designed an intervention that exposed participants to a detailed demonstration of laboratory processes. Each group was interviewed twice in a day, before and after exposure to the intervention in order to assess changes in their views. Factors that motivated people to participate in invasive biomedical research included a desire to stay healthy because of the screening during the recruitment process, regular advice from doctors, free medical services, and trust in the researchers. Inhibiting factors were limited knowledge about samples taken from their bodies during endoscopic procedures, the impact of endoscopy on the function of internal organs, and concerns about the use of biomedical samples. The belief that blood can be used for Satanic practices also created insecurities about drawing of blood samples. Further inhibiting factors included a fear of being labelled as HIV positive if known to consult heath workers repeatedly, and gender inequality. Concerns about the use and storage of blood and tissue samples were overcome by a laboratory exposure intervention. Selecting a group of members from target community and engaging them in a laboratory exposure intervention could be a useful tool for enhancing specific aspects of consent for biomedical research. Further work is needed to determine the extent to which improved understanding permeates beyond the immediate group participating in the intervention.

Improving validity of informed consent for biomedical research in Zambia using a laboratory exposure intervention.

Directory of Open Access Journals (Sweden)

Joseph Mumba Zulu

Full Text Available Complex biomedical research can lead to disquiet in communities with limited exposure to scientific discussions, leading to rumours or to high drop-out rates. We set out to test an intervention designed to address apprehensions commonly encountered in a community where literacy is uncommon, and where complex biomedical research has been conducted for over a decade. We aimed to determine if it could improve the validity of consent.Data were collected using focus group discussions, key informant interviews and observations. We designed an intervention that exposed participants to a detailed demonstration of laboratory processes. Each group was interviewed twice in a day, before and after exposure to the intervention in order to assess changes in their views.Factors that motivated people to participate in invasive biomedical research included a desire to stay healthy because of the screening during the recruitment process, regular advice from doctors, free medical services, and trust in the researchers. Inhibiting factors were limited knowledge about samples taken from their bodies during endoscopic procedures, the impact of endoscopy on the function of internal organs, and concerns about the use of biomedical samples. The belief that blood can be used for Satanic practices also created insecurities about drawing of blood samples. Further inhibiting factors included a fear of being labelled as HIV positive if known to consult heath workers repeatedly, and gender inequality. Concerns about the use and storage of blood and tissue samples were overcome by a laboratory exposure intervention.Selecting a group of members from target community and engaging them in a laboratory exposure intervention could be a useful tool for enhancing specific aspects of consent for biomedical research. Further work is needed to determine the extent to which improved understanding permeates beyond the immediate group participating in the intervention.

Infusing Qualitative Traditions in Counseling Research Designs

Science.gov (United States)

Hays, Danica G.; Wood, Chris

2011-01-01

Research traditions serve as a blueprint or guide for a variety of design decisions throughout qualitative inquiry. This article presents 6 qualitative research traditions: grounded theory, phenomenology, consensual qualitative research, ethnography, narratology, and participatory action research. For each tradition, the authors describe its…

Choosing an adequate design and analysis in cross-cultural personality research

NARCIS (Netherlands)

He, Jia; van de Vijver, Fons

2017-01-01

The flourishing of cross-cultural personality research requires a keen eye for rigorous methodology in such research. With decades of experience in cross-cultural research methods, we have come to appreciate that methodological aspects of such studies are critical for obtaining valid findings.

The Role of Hypothesis in Constructive Design Research

DEFF Research Database (Denmark)

Bang, Anne Louise; Krogh, Peter; Ludvigsen, Martin

2012-01-01

and solid perspective on how to keep constructive design research on track, this paper offers a model for understanding the role of hypothesis in constructive design research. The model allows for understanding the hypothesis’s relation to research motivation, questions, experiments, evaluation...... and knowledge production. The intention of the model is to have it serve as a tool in the research process aiding the researcher to understand at what “level” discussions and claims are brought forward, and what consequences these might have for the research work at hand. Thus, the paper claims the central...

Design research through practice : from the lab, field, and showroom

NARCIS (Netherlands)

Koskinen, I.; Zimmerman, J.; Binder, T.; Redström, J.; Wensveen, S.A.G.

2011-01-01

Businesses and the HCI and Interaction Design communities have embraced design and design research. Design research as a field blends methodologies from several disciplines - sociology, engineering, software, philosophy, industrial design, HCI/interaction design -- so designers can learn from past

Research on an innovative design model

Science.gov (United States)

Fu, Y.; Fang, H.

2018-03-01

The design methods of furniture are different from east to west; it has been the hotspot of the scholars. However, in terms of the theory of modern design innovation, neither the early creation theory, the modern design theory, nor the widely applied TRIZ theory can fully fit the modern furniture design innovation, so it is urgent to study the modern furniture design theory. This paper is based on the idea of TRIZ theory, using lots of literatures as data, and uses the method of statistical stratification to analyze and sort out the research of modern sitting equipment, and finally put forward the modern furniture design model, which provides new ideas and perspectives for the modern design of Chinese furniture.

Attending to Objects as Outcomes of Design Research

DEFF Research Database (Denmark)

Jenkins, Tom; Andersen, Kristina; Gaver, William

2016-01-01

outcomes. The premise of this workshop is simple: We need additional spaces for interacting with and reflecting upon material design outcomes at CHI. The goal of this workshop is to experiment with such a space, and to initially do so without a strong theoretical or conceptual framing.......The goal for this workshop is to provide a venue at CHI for research through design practitioners to materially share their work with each other. Conversation will largely be centered upon a discussion of objects produced through a research through design process. Bringing together researchers...

Design Research through the Lens of Sociology of Technology

DEFF Research Database (Denmark)

Berntsen, Hilde Østerås; Seim, Rikke

2007-01-01

The use of an approach to design research inspired by Sociology of Technology offers a nuanced understanding of design processes. The purpose of this paper is to explore how terminology derived from the socio-technical theory of Actor Network (ANT) can be used to understand the complexity of design...... processes by viewing these processes as building and alignment of networks. The applicability of ANT in design research is demonstrated in an analysis of an action research based case study. In this case study a socio-technical approach called “workspace design” is employed in a process of re......-design of existing workspace and work practice in an industrial company. The case study (i) illustrates a socio-technical approach to design research and (ii) shows how ANT terminology can be applied in an analysis of the course of events in a design process with numerous actors involved....

Review of external validity reporting in childhood obesity prevention research.

Science.gov (United States)

Klesges, Lisa M; Dzewaltowski, David A; Glasgow, Russell E

2008-03-01

The translation and dissemination of prevention intervention evidence into practice is needed to address significant public health issues such as childhood obesity. Increased attention to and reporting of external validity information in research publications would allow for better understanding of generalizability issues relevant to successful translation. To demonstrate this potential, recent reports of childhood obesity prevention interventions were evaluated on the extent to which external validity dimensions were reported. Childhood obesity prevention studies that were controlled, long-term research trials published between 1980 and 2004 that reported a behavioral target of physical activity and/or healthy eating along with at least one anthropometric outcome were identified in 2005. Studies were summarized between 2005 and 2006 using review criteria developed by Green and Glasgow in 2006. Nineteen publications met selection criteria. In general, all studies lacked full reporting on potential generalizability and dissemination elements. Median reporting over all elements was 34.5%; the mode was 0% with a range of 0% to 100%. Most infrequent were reports of setting level selection criteria and representativeness, characteristics regarding intervention staff, implementation of intervention content, costs, and program sustainability. The evidence base for future prevention interventions can be improved by enhancing the reporting of contextual and generalizability elements central to translational research. Such efforts face practical hurdles but could provide additional explanation for variability in intervention outcomes, insights into successful adaptations of interventions, and help guide policy decisions.

The European contribution to the development and validation activities for the design of IFMIF lithium facility

Energy Technology Data Exchange (ETDEWEB)

Miccichè, Gioacchino, E-mail: gioacchino.micciche@enea.it [EURATOM-ENEA, CR Brasimone I-40035 Camugnano, BO (Italy); Aiello, Antonio; Bernardi, Davide; Favuzza, Paolo; Agostini, Pietro [EURATOM-ENEA, CR Brasimone I-40035 Camugnano, BO (Italy); Frisoni, Manuela [EURATOM-ENEA, CR Bologna I-40129, BO Italy (Italy); Pinna, Tonio; Porfiri, MariaTeresa [EURATOM-ENEA, CR Frascati I-0044 Frascati, Roma (Italy); Tincani, Amelia [EURATOM-ENEA, CR Brasimone I-40035 Camugnano, BO (Italy); Di Maio, PieroAlessandro [University of Palermo, I-90128 Palermo (Italy); Knaepen, Bernard [Université libre de Bruxelles, I-1050 Bruxelles (Belgium)

2013-10-15

Highlights: • Engineering design of the target assembly. • Erosion, corrosion phenomena promoted by the lithium are studied. • Purification system implemented in the LiFus6 loop. • Study of the remote handling maintenance for the IFMIF TA. -- Abstract: The International Fusion Materials Irradiation Facility (IFMIF) is an accelerator-driven intense neutron source where candidate materials for fusion reactors will be tested and validated. The high energy neutron flux is produced by means of two deuteron beams (total current of 250 mA, energy of 40 MeV) that strikes a liquid lithium target circulating in a lithium loop of IFMIF plant. The European (EU) contribution to the development of the lithium facility comprises five procurement packages, as follow: (1) participation to the experimental activities of the EVEDA lithium test loop in Oarai (Japan); (2) study aimed at evaluating the corrosion and erosion phenomena, promoted by lithium, for structural fusion reference materials like AISI 316L and Eurofer; (3) design and validation of the lithium purification method with the aim to provide input data for the design of the purification system of IFIMF lithium loop; (4) design and validation of the remote handling (RH) procedures for the refurbishment/replacement of the EU concept of IFMIF target assembly including the design of the remote handling tools; (5) the engineering design of the European target assembly for IFMIF and the safety and RAMI analyses for the entire IFMIF lithium facility. The paper gives an overview of the status of the activities and of the main outcomes achieved so far.

The European contribution to the development and validation activities for the design of IFMIF lithium facility

International Nuclear Information System (INIS)

Miccichè, Gioacchino; Aiello, Antonio; Bernardi, Davide; Favuzza, Paolo; Agostini, Pietro; Frisoni, Manuela; Pinna, Tonio; Porfiri, MariaTeresa; Tincani, Amelia; Di Maio, PieroAlessandro; Knaepen, Bernard

2013-01-01

Highlights: • Engineering design of the target assembly. • Erosion, corrosion phenomena promoted by the lithium are studied. • Purification system implemented in the LiFus6 loop. • Study of the remote handling maintenance for the IFMIF TA. -- Abstract: The International Fusion Materials Irradiation Facility (IFMIF) is an accelerator-driven intense neutron source where candidate materials for fusion reactors will be tested and validated. The high energy neutron flux is produced by means of two deuteron beams (total current of 250 mA, energy of 40 MeV) that strikes a liquid lithium target circulating in a lithium loop of IFMIF plant. The European (EU) contribution to the development of the lithium facility comprises five procurement packages, as follow: (1) participation to the experimental activities of the EVEDA lithium test loop in Oarai (Japan); (2) study aimed at evaluating the corrosion and erosion phenomena, promoted by lithium, for structural fusion reference materials like AISI 316L and Eurofer; (3) design and validation of the lithium purification method with the aim to provide input data for the design of the purification system of IFIMF lithium loop; (4) design and validation of the remote handling (RH) procedures for the refurbishment/replacement of the EU concept of IFMIF target assembly including the design of the remote handling tools; (5) the engineering design of the European target assembly for IFMIF and the safety and RAMI analyses for the entire IFMIF lithium facility. The paper gives an overview of the status of the activities and of the main outcomes achieved so far

Involving Latina/o parents in patient-centered outcomes research: Contributions to research study design, implementation and outcomes.

Science.gov (United States)

Pérez Jolles, Mónica; Martinez, Maria; Garcia, San Juanita; Stein, Gabriela L; Thomas, Kathleen C

2017-10-01

Comparative effectiveness research (CER) is supported by policymakers as a way to provide service providers and patients with evidence-based information to make better health-care decisions and ultimately improve services for patients. However, Latina/o patients are rarely involved as study advisors, and there is a lack of documentation on how their voices contribute to the research process when they are included as collaborators. The purpose of this article was to contribute to the literature by presenting concrete contributions of Latina/o parent involvement to study design, implementation and outcomes in the context of a CER study called Padres Efectivos (Parent Activation). Researchers facilitated a collaborative relationship with parents by establishing a mentor parent group. The contributions of parent involvement in the following stages of the research process are described: (i) proposal development, (ii) implementation of protocols, (iii) analysis plan and (iv) dissemination of results. Mentor parents' contributions helped tailor the content of the intervention to their needs during proposal, increased recruitment, validated the main outcome measure and added two important outcome measures, emphasized the importance of controlling for novice treatment status and developed innovative dissemination strategies. Mentor parents' guidance to the researchers has contributed to reaching recruitment goals, strengthened the study protocol, expanded findings, supported broad ownership of study implications and enriched the overall study data collection efforts. These findings can inform future research efforts seeking an active Latino parent collaboration and the timely incorporation of parent voices in each phase of the research process. © 2017 The Authors Health Expectations Published by John Wiley & Sons Ltd.

Design study of underground facility of the Underground Research Laboratory

International Nuclear Information System (INIS)

Hibiya, Keisuke; Akiyoshi, Kenji; Ishizuka, Mineo; Anezaki, Susumu

1998-03-01

Geoscientific research program to study deep geological environment has been performed by Power Reactor and Nuclear Fuel Development Corporation (PNC). This research is supported by 'Long-Term Program for Research, Development and Utilization of Nuclear Energy'. An Underground Research Laboratory is planned to be constructed at Shoma-sama Hora in the research area belonging to PNC. A wide range of geoscientific research and development activities which have been previously studied at the Tono Area is planned in the laboratory. The Underground Research Laboratory is consisted of Surface Laboratory and Underground Research Facility located from the surface down to depth between several hundreds and 1,000 meters. Based on the results of design study in last year, the design study performed in this year is to investigate the followings in advance of studies for basic design and practical design: concept, design procedure, design flow and total layout. As a study for the concept of the underground facility, items required for the facility are investigated and factors to design the primary form of the underground facility are extracted. Continuously, design methods for the vault and the underground facility are summarized. Furthermore, design procedures of the extracted factors are summarized and total layout is studied considering the results to be obtained from the laboratory. (author)

Experimental validation of thermal design of top shield for a pool type SFR

International Nuclear Information System (INIS)

Aithal, Sriramachandra; Babu, V. Rajan; Balasubramaniyan, V.; Velusamy, K.; Chellapandi, P.

2016-01-01

Highlights: • Overall thermal design of top shield in a SFR is experimentally verified. • Air jet cooling is effective in ensuring the temperatures limits for top shield. • Convection patterns in narrow annulus are in line with published CFD results. • Wire mesh insulation ensures gradual thermal gradient at top portion of main vessel. • Under loss of cooling scenario, sufficient time is available for corrective action. - Abstract: An Integrated Top Shield Test Facility towards validation of thermal design of top shield for a pool type SFR has been conceived, constructed & commissioned. Detailed experiments were performed in this experimental facility having full-scale features. Steady state temperature distribution within the facility is measured for various heater plate temperatures in addition to simulating different operating states of the reactor. Following are the important observations (i) jet cooling system is effective in regulating the roof slab bottom plate temperature and thermal gradient across roof slab simulating normal operation of reactor, (ii) wire mesh insulation provided in roof slab-main vessel annulus is effective in obtaining gradual thermal gradient along main vessel top portion and inhibiting the setting up of cellular convection within annulus and (iii) cellular convection with four distinct convective cells sets in the annular gap between roof slab and small rotatable plug measuring ∼ϕ4 m in diameter & gap width varying from 16 mm to 30 mm. Repeatability of results is also ensured during all the above tests. The results presented in this paper is expected to provide reference data for validation of thermal hydraulic models in addition to serving as design validation of jet cooling system for pool type SFR.

Non-clinical models: validation, study design and statistical consideration in safety pharmacology.

Science.gov (United States)

Pugsley, M K; Towart, R; Authier, S; Gallacher, D J; Curtis, M J

2010-01-01

The current issue of the Journal of Pharmacological and Toxicological Methods (JPTM) focuses exclusively on safety pharmacology methods. This is the 7th year the Journal has published on this topic. Methods and models that specifically relate to methods relating to the assessment of the safety profile of a new chemical entity (NCE) prior to first in human (FIH) studies are described. Since the Journal started publishing on this topic there has been a major effort by safety pharmacologists, toxicologists and regulatory scientists within Industry (both large and small Pharma as well as Biotechnology companies) and also from Contract Research Organizations (CRO) to publish the surgical details of the non-clinical methods utilized but also provide important details related to standard and non-standard (or integrated) study models and designs. These details from core battery and secondary (or ancillary) drug safety assessment methods used in drug development programs have been the focus of these special issues and have been an attempt to provide validation of methods. Similarly, the safety pharmacology issues of the Journal provide the most relevant forum for scientists to present novel and modified methods with direct applicability to determination of drug safety-directly to the safety pharmacology scientific community. The content of the manuscripts in this issue includes the introduction of additional important surgical methods, novel data capture and data analysis methods, improved study design and effects of positive control compounds with known activity in the model. Copyright 2010 Elsevier Inc. All rights reserved.

Validation study of the early onset schizophrenia diagnosis in the Danish Psychiatric Central Research Register

DEFF Research Database (Denmark)

Vernal, Ditte Lammers; Stenstrøm, Anne Dorte; Staal, Nina

2018-01-01

on classification. Compared to diagnoses made in outpatient settings, EOS diagnoses during hospitalizations were more likely to be valid and had fewer registration errors. Diagnosed in inpatient settings, EOS diagnoses are reliable and valid for register-based research. Schizophrenia diagnosed in children...... and adolescents in outpatient settings were found to have a high number of false-positives, both due to registration errors and diagnostic practice. Utilizing this knowledge, it is possible to reduce the number of false-positives in register-based research of EOS....

Research program to develop and validate conceptual models for flow and transport through unsaturated, fractured rock

International Nuclear Information System (INIS)

Glass, R.J.; Tidwell, V.C.

1991-01-01

As part of the Yucca Mountain Project, our research program to develop and validate conceptual models for flow and transport through unsaturated fractured rock integrates fundamental physical experimentation with conceptual model formulation and mathematical modeling. Our research is directed toward developing and validating macroscopic, continuum-based models and supporting effective property models because of their widespread utility within the context of this project. Success relative to the development and validation of effective property models is predicated on a firm understanding of the basic physics governing flow through fractured media, specifically in the areas of unsaturated flow and transport in a single fracture and fracture-matrix interaction. 43 refs

Research program to develop and validate conceptual models for flow and transport through unsaturated, fractured rock

International Nuclear Information System (INIS)

Glass, R.J.; Tidwell, V.C.

1991-09-01

As part of the Yucca Mountain Project, our research program to develop and validate conceptual models for flow and transport through unsaturated fractured rock integrates fundamental physical experimentation with conceptual model formulation and mathematical modeling. Our research is directed toward developing and validating macroscopic, continuum-based models and supporting effective property models because of their widespread utility within the context of this project. Success relative to the development and validation of effective property models is predicted on a firm understanding of the basic physics governing flow through fractured media, specifically in the areas of unsaturated flow and transport in a single fracture and fracture-matrix interaction

Research program to develop and validate conceptual models for flow and transport through unsaturated, fractured rock

International Nuclear Information System (INIS)

Glass, R.J.; Tidwell, V.C.

1991-01-01

As part of the Yucca Mountain Project, our research program to develop and validate conceptual models for flow and transport through unsaturated fractured rock integrates fundamental physical experimentation with conceptual model formulation and mathematical modeling. Our research is directed toward developing and validating macroscopic, continuum-based models and supporting effective property models because of their widespread utility within the context of this project. Success relative to the development and validation of effective property models is predicted on a firm understanding of the basic physics governing flow through fractured media, specifically in the areas of unsaturated flow and transport in a single fracture and fracture-matrix interaction

[Design and validation of an oral health questionnaire for preoperative anaesthetic evaluation].

Science.gov (United States)

Ruíz-López Del Prado, Gema; Blaya-Nováková, Vendula; Saz-Parkinson, Zuleika; Álvarez-Montero, Óscar Luis; Ayala, Alba; Muñoz-Moreno, Maria Fe; Forjaz, Maria João

Dental injuries incurred during endotracheal intubation are more frequent in patients with previous oral pathology. The study objectives were to develop an oral health questionnaire for preanaesthesia evaluation, easy to apply for personnel without special dental training; and establish a cut-off value for detecting persons with poor oral health. Validation study of a self-administered questionnaire, designed according to a literature review and an expert group's recommendations. The questionnaire was applied to a sample of patients evaluated in a preanaesthesia consultation. Rasch analysis of the questionnaire psychometric properties included viability, acceptability, content validity and reliability of the scale. The sample included 115 individuals, 50.4% of men, with a median age of 58 years (range: 38-71). The final analysis of 11 items presented a Person Separation Index of 0.861 and good adjustment of data to the Rasch model. The scale was unidimensional and its items were not biased by sex, age or nationality. The oral health linear measure presented good construct validity. The cut-off value was set at 52 points. The questionnaire showed sufficient psychometric properties to be considered a reliable tool, valid for measuring the state of oral health in preoperative anaesthetic evaluations. Copyright © 2016 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.

Design and validation of an oral health questionnaire for preoperative anaesthetic evaluation

Directory of Open Access Journals (Sweden)

Gema Ruíz-López del Prado

Full Text Available Abstract Background and objectives: Dental injuries incurred during endotracheal intubation are more frequent in patients with previous oral pathology. The study objectives were to develop an oral health questionnaire for preanaesthesia evaluation, easy to apply for personnel without special dental training; and establish a cut-off value for detecting persons with poor oral health. Methods: Validation study of a self-administered questionnaire, designed according to a literature review and an expert group's recommendations. The questionnaire was applied to a sample of patients evaluated in a preanaesthesia consultation. Rasch analysis of the questionnaire psychometric properties included viability, acceptability, content validity and reliability of the scale. Results: The sample included 115 individuals, 50.4% of men, with a median age of 58 years (range: 38-71. The final analysis of 11 items presented a Person Separation Index of 0.861 and good adjustment of data to the Rasch model. The scale was unidimensional and its items were not biased by sex, age or nationality. The oral health linear measure presented good construct validity. The cut-off value was set at 52 points. Conclusions: The questionnaire showed sufficient psychometric properties to be considered a reliable tool, valid for measuring the state of oral health in preoperative anaesthetic evaluations.

Designing and validation of a yoga-based intervention for obsessive compulsive disorder.

Science.gov (United States)

Bhat, Shubha; Varambally, Shivarama; Karmani, Sneha; Govindaraj, Ramajayam; Gangadhar, B N

2016-06-01

Some yoga-based practices have been found to be useful for patients with obsessive compulsive disorder (OCD). The authors could not find a validated yoga therapy module available for OCD. This study attempted to formulate a generic yoga-based intervention module for OCD. A yoga module was designed based on traditional and contemporary yoga literature. The module was sent to 10 yoga experts for content validation. The experts rated the usefulness of the practices on a scale of 1-5 (5 = extremely useful). The final version of the module was pilot-tested on patients with OCD (n = 17) for both feasibility and effect on symptoms. Eighty-eight per cent (22 out of 25) of the items in the initial module were retained, with modifications in the module as suggested by the experts along with patients' inputs and authors' experience. The module was found to be feasible and showed an improvement in symptoms of OCD on total Yale-Brown Obsessive-Compulsive Scale (YBOCS) score (p = 0.001). A generic yoga therapy module for OCD was validated by experts in the field and found feasible to practice in patients. A decrease in the symptom scores was also found following yoga practice of 2 weeks. Further clinical validation is warranted to confirm efficacy.