WorldWideScience

Sample records for reported large gains

  1. Leading Gainful Employment Metric Reporting

    Science.gov (United States)

    Powers, Kristina; MacPherson, Derek

    2016-01-01

    This chapter will address the importance of intercampus involvement in reporting of gainful employment student-level data that will be used in the calculation of gainful employment metrics by the U.S. Department of Education. The authors will discuss why building relationships within the institution is critical for effective gainful employment…

  2. Beyond Multiplexing Gain in Large MIMO Systems

    DEFF Research Database (Denmark)

    Cakmak, Burak; Müller, Ralf R.; Fleury, Bernard Henri

    growth (multiplexing gain). Even when the channel entries are i.i.d. the deviation from the linear growth is significant. We also find an additive property of the deviation for a concatenated MIMO system. Finally, we quantify the deviation of the large SNR capacity from the exact capacity and find...

  3. GAIN Technology Workshops Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Braase, Lori Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-08-01

    National and global demand for nuclear energy is increasing and United States (U.S.) global leadership is eroding. There is a sense of urgency with respect to the deployment of the innovative nuclear energy technologies. The Gateway for Accelerated Innovation in Nuclear (GAIN) initiative is based on the simultaneous achievement of three strategic goals. The first is maintaining global technology leadership within the U.S. Department of Energy (DOE). The second is enabling global industrial leadership for nuclear vendors and suppliers. The third is focused on utility optimization of nuclear energy within the clean energy portfolio. An effective public-private partnership is required to achieve these goals. DOEs recognizes the recent sense of urgency new developers and investors have in getting their concepts to market. They know that time to market for nuclear technology takes too long and the facilities needed to conduct the necessary research, development and demonstration (RD&D) activities are very expensive to develop and maintain. Early technologies, in the lower technology readiness levels (TRL) need materials testing, analysis, modeling, code development, etc., most of which currently exists in the DOE national laboratory system. However, mature technologies typically need large component testing and demonstration facilities, which are expensive and long-lead efforts. By understanding the needs of advanced nuclear technology developers, GAIN will connect DOE national laboratory capabilities (e.g., facilities, expertise, materials, and data) with industry RD&D needs. In addition, GAIN is working with the Nuclear Regulatory Commission (NRC) to streamline processes and increase understanding of the licensing requirements for advanced reactors.

  4. GAIN Technology Workshops Summary Report

    International Nuclear Information System (INIS)

    Braase, Lori Ann

    2016-01-01

    National and global demand for nuclear energy is increasing and United States (U.S.) global leadership is eroding. There is a sense of urgency with respect to the deployment of the innovative nuclear energy technologies. The Gateway for Accelerated Innovation in Nuclear (GAIN) initiative is based on the simultaneous achievement of three strategic goals. The first is maintaining global technology leadership within the U.S. Department of Energy (DOE). The second is enabling global industrial leadership for nuclear vendors and suppliers. The third is focused on utility optimization of nuclear energy within the clean energy portfolio. An effective public-private partnership is required to achieve these goals. DOEs recognizes the recent sense of urgency new developers and investors have in getting their concepts to market. They know that time to market for nuclear technology takes too long and the facilities needed to conduct the necessary research, development and demonstration (RD&D) activities are very expensive to develop and maintain. Early technologies, in the lower technology readiness levels (TRL) need materials testing, analysis, modeling, code development, etc., most of which currently exists in the DOE national laboratory system. However, mature technologies typically need large component testing and demonstration facilities, which are expensive and long-lead efforts. By understanding the needs of advanced nuclear technology developers, GAIN will connect DOE national laboratory capabilities (e.g., facilities, expertise, materials, and data) with industry RD&D needs. In addition, GAIN is working with the Nuclear Regulatory Commission (NRC) to streamline processes and increase understanding of the licensing requirements for advanced reactors.

  5. Robust Optimal Adaptive Control Method with Large Adaptive Gain

    Science.gov (United States)

    Nguyen, Nhan T.

    2009-01-01

    In the presence of large uncertainties, a control system needs to be able to adapt rapidly to regain performance. Fast adaptation is referred to the implementation of adaptive control with a large adaptive gain to reduce the tracking error rapidly. However, a large adaptive gain can lead to high-frequency oscillations which can adversely affect robustness of an adaptive control law. A new adaptive control modification is presented that can achieve robust adaptation with a large adaptive gain without incurring high-frequency oscillations as with the standard model-reference adaptive control. The modification is based on the minimization of the Y2 norm of the tracking error, which is formulated as an optimal control problem. The optimality condition is used to derive the modification using the gradient method. The optimal control modification results in a stable adaptation and allows a large adaptive gain to be used for better tracking while providing sufficient stability robustness. Simulations were conducted for a damaged generic transport aircraft with both standard adaptive control and the adaptive optimal control modification technique. The results demonstrate the effectiveness of the proposed modification in tracking a reference model while maintaining a sufficient time delay margin.

  6. A digital gain stabilizer for large volume organic scintillation detectors

    International Nuclear Information System (INIS)

    Braunsfurth, J.; Geske, K.

    1976-01-01

    A digital gain stabilizer is described, optimized for use with photomultipliers mounted on large volume organic scintillators, or other radiation detectors, which exhibit no prominent peaks in their amplitude spectra. As applications of this kind usually involve many phototubes or detectors, circuit simplicity, production reproduceability, and the possibility of computer controlled operation were major design criteria. Two versions were built, the first one using standard TTL-SSI and MSI circuitry, the second one - to reduce power requirements - using a mixture of TTL- and CMOS-LSI circuits. (Auth.)

  7. Assigning probability gain for precursors of four large Chinese earthquakes

    Energy Technology Data Exchange (ETDEWEB)

    Cao, T.; Aki, K.

    1983-03-10

    We extend the concept of probability gain associated with a precursor (Aki, 1981) to a set of precursors which may be mutually dependent. Making use of a new formula, we derive a criterion for selecting precursors from a given data set in order to calculate the probability gain. The probabilities per unit time immediately before four large Chinese earthquakes are calculated. They are approximately 0.09, 0.09, 0.07 and 0.08 per day for 1975 Haicheng (M = 7.3), 1976 Tangshan (M = 7.8), 1976 Longling (M = 7.6), and Songpan (M = 7.2) earthquakes, respectively. These results are encouraging because they suggest that the investigated precursory phenomena may have included the complete information for earthquake prediction, at least for the above earthquakes. With this method, the step-by-step approach to prediction used in China may be quantified in terms of the probability of earthquake occurrence. The ln P versus t curve (where P is the probability of earthquake occurrence at time t) shows that ln P does not increase with t linearly but more rapidly as the time of earthquake approaches.

  8. Large conservation gains possible for global biodiversity facets

    Science.gov (United States)

    Pollock, Laura J.; Thuiller, Wilfried; Jetz, Walter

    2017-06-01

    Different facets of biodiversity other than species numbers are increasingly appreciated as critical for maintaining the function of ecosystems and their services to humans. While new international policy and assessment processes such as the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) recognize the importance of an increasingly global, quantitative and comprehensive approach to biodiversity protection, most insights are still focused on a single facet of biodiversity—species. Here we broaden the focus and provide an evaluation of how much of the world’s species, functional and phylogenetic diversity of birds and mammals is currently protected and the scope for improvement. We show that the large existing gaps in the coverage for each facet of diversity could be remedied by a slight expansion of protected areas: an additional 5% of the land has the potential to more than triple the protected range of species or phylogenetic or functional units. Further, the same areas are often priorities for multiple diversity facets and for both taxa. However, we find that the choice of conservation strategy has a fundamental effect on outcomes. It is more difficult (that is, requires more land) to maximize basic representation of the global biodiversity pool than to maximize local diversity. Overall, species and phylogenetic priorities are more similar to each other than they are to functional priorities, and priorities for the different bird biodiversity facets are more similar than those of mammals. Our work shows that large gains in biodiversity protection are possible, while also highlighting the need to explicitly link desired conservation objectives and biodiversity metrics. We provide a framework and quantitative tools to advance these goals for multi-faceted biodiversity conservation.

  9. Large conservation gains possible for global biodiversity facets.

    Science.gov (United States)

    Pollock, Laura J; Thuiller, Wilfried; Jetz, Walter

    2017-06-01

    Different facets of biodiversity other than species numbers are increasingly appreciated as critical for maintaining the function of ecosystems and their services to humans. While new international policy and assessment processes such as the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) recognize the importance of an increasingly global, quantitative and comprehensive approach to biodiversity protection, most insights are still focused on a single facet of biodiversity-species. Here we broaden the focus and provide an evaluation of how much of the world's species, functional and phylogenetic diversity of birds and mammals is currently protected and the scope for improvement. We show that the large existing gaps in the coverage for each facet of diversity could be remedied by a slight expansion of protected areas: an additional 5% of the land has the potential to more than triple the protected range of species or phylogenetic or functional units. Further, the same areas are often priorities for multiple diversity facets and for both taxa. However, we find that the choice of conservation strategy has a fundamental effect on outcomes. It is more difficult (that is, requires more land) to maximize basic representation of the global biodiversity pool than to maximize local diversity. Overall, species and phylogenetic priorities are more similar to each other than they are to functional priorities, and priorities for the different bird biodiversity facets are more similar than those of mammals. Our work shows that large gains in biodiversity protection are possible, while also highlighting the need to explicitly link desired conservation objectives and biodiversity metrics. We provide a framework and quantitative tools to advance these goals for multi-faceted biodiversity conservation.

  10. 1999 Annual report: Gaining momentum, creating value

    International Nuclear Information System (INIS)

    2000-01-01

    Danoil Energy is an oil and gas company engaged in exploration, development and acquisition of both oil and natural gas reserves in western Canada. The company is based in Calgary. In 1999, the company had revenues of $29.5 million from natural gas sales and from the sale of crude oil and natural gas liquids, an increase of 56 per cent over the previous year. Net earnings amounted to $2.7 million, or 12 cents a share. Production also increased about 15 per cent in 1999 and is forecast to increase 32 per cent over 1999 levels in 2000. Production has been replaced by 150 per cent, bringing current total reserves to 29,239 MMcf/d of natural gas and 11,238 Mbbls of crude oil and natural gas liquids. The company has 71,149 acres of undeveloped lands. The report contains a review of the property, a review of operations, consolidated financial statements, and management's analysis and discussion of operating and financial results

  11. Large block test status report

    International Nuclear Information System (INIS)

    Wilder, D.G.; Lin, W.; Blair, S.C.

    1997-01-01

    This report is intended to serve as a status report, which essentially transmits the data that have been collected to date on the Large Block Test (LBT). The analyses of data will be performed during FY98, and then a complete report will be prepared. This status report includes introductory material that is not needed merely to transmit data but is available at this time and therefore included. As such, this status report will serve as the template for the future report, and the information is thus preserved

  12. LARGE BLOCK TEST STATUS REPORT

    International Nuclear Information System (INIS)

    D.G. WILDER, W. LIN, S.C. BLAIR, T. BUSCHECK, R.C. CARLSON, K. LEE, A. MEIKE, A.L. RAMIREZ, J.L. WAGONER, AND J. WANG

    1997-01-01

    This report is intended to serve as a status report, which essentially transmits the data that have been collected to date on the Large Block Test (LBT). The analyses of data will be performed during FY98, and then a complete report will be prepared. This status report includes introductory material that is not needed merely to transmit data but is available at this time and therefore included. As such, this status report will serve as the template for the future report, and the information is thus preserved. The United States Department of Energy (DOE) is investigatinq the suitability of Yucca Mountain (YM) as a potential site for the nation's first high-level nuclear waste repository. As shown in Fig. 1-1, the site is located about 120 km northwest of Las Vegas, Nevada, in an area of uninhabited desert

  13. Experience gained with Euratom's nuclear materials accounting and reporting system

    International Nuclear Information System (INIS)

    Schmitt, M.; Kschwendt, H.; Maxwell, A.G.; Littlejohn, M.

    1979-01-01

    The entry into force of the Verification Agreement in early 1977, linked to the wish to update the old Euratom System created in 1959, required that a new Euratom system (Community Regulation) be established. The main aspects of this new system, together with the practical experience gained in one and a half years operation, are presented. Certain basic accounting principles incorporated in the Euratom system, which are somewhat different from IAEA principles, are discussed in detail. This includes the notion of accounting date, some correction procedure aspects as well as the continuous updating of the book inventory to the physical reality in form of inventory changes. The effect of these differences when comparing IAEA and Euratom data is also mentioned. Furthermore, certain of the verifications carried out routinely on the operator's reports as well as on the reports submitted by Euratom to IAEA, are described and quantifications are given. Some mention is also made of areas where Euratom's role goes beyond that of the IAEA, i.e. the reporting implications of accounting for material by origin and control of particular use of the materials as well as verification of ore production and processing activities. Finally, improvements and simplifications concerning reports to the IAEA are proposed. (author)

  14. Frequency domain design of gain scheduling control for large wind systems in full-load region

    International Nuclear Information System (INIS)

    Burlibaşa, A.; Ceangă, E.

    2014-01-01

    Highlights: • A large wind energy system, operating under full-load regime, is considered. • According to its particularities in frequency domain, control law design is provided. • These particularities are influenced by the interactions of wind–tower–blade ensemble. • Control low, within gain scheduling strategy, is achieved imposing stability reserve. • Supplementary a criterion, aimed at reducing mechanical loads, is imposed. - Abstract: The paper presents the issue of power control law synthesis, in the case of a large wind system that operates under full-load regime, based on dynamic properties details in frequency domain. Solving this problem involves two phases: the establishment of a linearized model as faithfully as possible in various operating points of the full-load region, and synthesis of the power controller, considered with classic structure, taking into account frequency particularities of the obtained linearized model. Obtained linear model of the controlled process is of order 16 and encloses subsystems for tower fore-aft oscillations damping, and for drive-train torsion oscillations damping. The designed controller contains a PI component and a lag compensator for dynamic correction at high frequencies. It is known that the main features of wind system dynamics generated by the interaction of wind–tower–blade ensemble cause a gap in the gain characteristic of the model and complex conjugate zeros, which can move between right and left half-planes, depending on the average wind speed value. Consequently, for control law synthesis an interactive frequency solution is adopted. This is “transparent” in relation to particularities induced by wind–tower–blade interaction. This solution allows evaluation of the extent to which control law is affected by the subsystem for tower oscillations damping. Given the strong dependence between the model and the mean wind speed value, a gain scheduling control law is designed. At

  15. Fluorescence-enhanced optical imaging in large tissue volumes using a gain-modulated ICCD camera

    International Nuclear Information System (INIS)

    Godavarty, Anuradha; Eppstein, Margaret J; Zhang, Chaoyang; Theru, Sangeeta; Thompson, Alan B; Gurfinkel, Michael; Sevick-Muraca, Eva M

    2003-01-01

    A novel image-intensified charge-coupled device (ICCD) imaging system has been developed to perform 3D fluorescence tomographic imaging in the frequency-domain using near-infrared contrast agents. The imager is unique since it (i) employs a large tissue-mimicking phantom, which is shaped and sized to resemble a female breast and part of the extended chest-wall region, and (ii) enables rapid data acquisition in the frequency-domain by using a gain-modulated ICCD camera. Diffusion model predictions are compared to experimental measurements using two different referencing schemes under two different experimental conditions of perfect and imperfect uptake of fluorescent agent into a target. From these experimental measurements, three-dimensional images of fluorescent absorption were reconstructed using a computationally efficient variant of the approximate extended Kalman filter algorithm. The current work represents the first time that 3D fluorescence-enhanced optical tomographic reconstructions have been achieved from experimental measurements of the time-dependent light propagation on a clinically relevant breast-shaped tissue phantom using a gain-modulated ICCD camera

  16. Large Gain in Air Quality Compared to an Alternative Anthropogenic Emissions Scenario

    Science.gov (United States)

    Daskalakis, Nikos; Tsigaridis, Kostas; Myriokefalitakis, Stelios; Fanourgakis, George S.; Kanakidou, Maria

    2016-01-01

    During the last 30 years, significant effort has been made to improve air quality through legislation for emissions reduction. Global three-dimensional chemistrytransport simulations of atmospheric composition over the past 3 decades have been performed to estimate what the air quality levels would have been under a scenario of stagnation of anthropogenic emissions per capita as in 1980, accounting for the population increase (BA1980) or using the standard practice of neglecting it (AE1980), and how they compare to the historical changes in air quality levels. The simulations are based on assimilated meteorology to account for the yearto- year observed climate variability and on different scenarios of anthropogenic emissions of pollutants. The ACCMIP historical emissions dataset is used as the starting point. Our sensitivity simulations provide clear indications that air quality legislation and technology developments have limited the rapid increase of air pollutants. The achieved reductions in concentrations of nitrogen oxides, carbon monoxide, black carbon, and sulfate aerosols are found to be significant when comparing to both BA1980 and AE1980 simulations that neglect any measures applied for the protection of the environment. We also show the potentially large tropospheric air quality benefit from the development of cleaner technology used by the growing global population. These 30-year hindcast sensitivity simulations demonstrate that the actual benefit in air quality due to air pollution legislation and technological advances is higher than the gain calculated by a simple comparison against a constant anthropogenic emissions simulation, as is usually done. Our results also indicate that over China and India the beneficial technological advances for the air quality may have been masked by the explosive increase in local population and the disproportional increase in energy demand partially due to the globalization of the economy.

  17. Large gain in air quality compared to an alternative anthropogenic emissions scenario

    Directory of Open Access Journals (Sweden)

    N. Daskalakis

    2016-08-01

    Full Text Available During the last 30 years, significant effort has been made to improve air quality through legislation for emissions reduction. Global three-dimensional chemistry-transport simulations of atmospheric composition over the past 3 decades have been performed to estimate what the air quality levels would have been under a scenario of stagnation of anthropogenic emissions per capita as in 1980, accounting for the population increase (BA1980 or using the standard practice of neglecting it (AE1980, and how they compare to the historical changes in air quality levels. The simulations are based on assimilated meteorology to account for the year-to-year observed climate variability and on different scenarios of anthropogenic emissions of pollutants. The ACCMIP historical emissions dataset is used as the starting point. Our sensitivity simulations provide clear indications that air quality legislation and technology developments have limited the rapid increase of air pollutants. The achieved reductions in concentrations of nitrogen oxides, carbon monoxide, black carbon, and sulfate aerosols are found to be significant when comparing to both BA1980 and AE1980 simulations that neglect any measures applied for the protection of the environment. We also show the potentially large tropospheric air quality benefit from the development of cleaner technology used by the growing global population. These 30-year hindcast sensitivity simulations demonstrate that the actual benefit in air quality due to air pollution legislation and technological advances is higher than the gain calculated by a simple comparison against a constant anthropogenic emissions simulation, as is usually done. Our results also indicate that over China and India the beneficial technological advances for the air quality may have been masked by the explosive increase in local population and the disproportional increase in energy demand partially due to the globalization of the economy.

  18. Large Signal Circuit Model of Two-Section Gain Lever Quantum Dot Laser

    International Nuclear Information System (INIS)

    Horri Ashkan; Mirmoeini Seyedeh Zahra; Faez Rahim

    2012-01-01

    An equivalent circuit model for the design and analysis of two-section gain lever quantum dot (QD) laser is presented. This model is based on the three level rate equations with two independent carrier populations and a single longitudinal optical mode. By using the presented model, the effect of gain lever on QD laser performances is investigated. The results of simulation show that the main characteristics of laser such as threshold current, transient response, output power and modulation response are affected by differential gain ratios between the two-sections

  19. Job gains and losses at large and small firms during the Great Recession

    OpenAIRE

    Juan M. Sánchez; Lowell R. Ricketts

    2012-01-01

    Conventional wisdom says that employment at small firms declines more than employment at large firms during recessions. However, that doesn’t seem to have been the case during the Great Recession of 2007-09.

  20. Intermodal parametric gain of degenerate four wave mixing in large mode area hybrid photonic crystal fibers

    DEFF Research Database (Denmark)

    Petersen, Sidsel Rübner; Lægsgaard, Jesper; Alkeskjold, Thomas Tanggaard

    2013-01-01

    Intermodal degenerate four wave mixing (FWM) is investigated numerically in large mode area hybrid photonic crystal fibers. The dispersion is controlled independently of core size, and thus allows for power scaling of the FWM process.......Intermodal degenerate four wave mixing (FWM) is investigated numerically in large mode area hybrid photonic crystal fibers. The dispersion is controlled independently of core size, and thus allows for power scaling of the FWM process....

  1. Isocurvature modes and Baryon Acoustic Oscillations II: gains from combining CMB and Large Scale Structure

    International Nuclear Information System (INIS)

    Carbone, Carmelita; Mangilli, Anna; Verde, Licia

    2011-01-01

    We consider cosmological parameters estimation in the presence of a non-zero isocurvature contribution in the primordial perturbations. A previous analysis showed that even a tiny amount of isocurvature perturbation, if not accounted for, could affect standard rulers calibration from Cosmic Microwave Background observations such as those provided by the Planck mission, affect Baryon Acoustic Oscillations interpretation, and introduce biases in the recovered dark energy properties that are larger than forecasted statistical errors from future surveys. Extending on this work, here we adopt a general fiducial cosmology which includes a varying dark energy equation of state parameter and curvature. Beside Baryon Acoustic Oscillations measurements, we include the information from the shape of the galaxy power spectrum and consider a joint analysis of a Planck-like Cosmic Microwave Background probe and a future, space-based, Large Scale Structure probe not too dissimilar from recently proposed surveys. We find that this allows one to break the degeneracies that affect the Cosmic Microwave Background and Baryon Acoustic Oscillations combination. As a result, most of the cosmological parameter systematic biases arising from an incorrect assumption on the isocurvature fraction parameter f iso , become negligible with respect to the statistical errors. We find that the Cosmic Microwave Background and Large Scale Structure combination gives a statistical error σ(f iso ) ∼ 0.008, even when curvature and a varying dark energy equation of state are included, which is smaller that the error obtained from Cosmic Microwave Background alone when flatness and cosmological constant are assumed. These results confirm the synergy and complementarity between Cosmic Microwave Background and Large Scale Structure, and the great potential of future and planned galaxy surveys

  2. Challenges in Gaining Large Scale Carbon Reductions through Wireless Home Automation Systems

    DEFF Research Database (Denmark)

    Larsen, Peter Gorm; Rovsing, Poul Ejnar; Toftegaard, Thomas Skjødeberg

    2010-01-01

    Buildings account for more than a 35 % of the energy consumption in Europe. Therefore a step towards more sustainable lifestile is to use home automation to optimize the energy consumption “automatically”. This paper reports about the usage and some of the remaining challenges of especially...... wireless but also powerline communication in a home automation setting. For many years, home automation has been visible to many, but accessible to only a few, because of inadequate integration of systems. A vast number of both standard and proprietary communication protocols are used, and systems...... are often difficult to install and configure so professional assistance is needed. In this paper we report about our experience in constructing an open universal home automation framework enabling interoperability of multiple communication protocols. The framework can easily be expanded in order to support...

  3. Experience Gained From the Construction, Test and Operation of the Large 4-T CMS Coil

    CERN Document Server

    Hervé, A; Curé, B; Fabbricatore, P; Gaddi, A; Kircher, F; Sgobba, S

    2008-01-01

    The 4-T, 6-m free bore CMS solenoid has been successfully tested, operated and mapped at CERN during the autumn of 2006; R&D studies started in 1993 and the construction proper in 1997. The main parameters of this 100 MUS$ project (including yoke) were then considered beyond what was thought possible, as the total stored magnetic energy reaches 2.6 GJ for a specific magnetic energy density exceeding 11 kJ/kg of cold mass. During this period, the international design and construction team had to make several important technical choices, in particular mechanical, to maximize the chances of reaching the nominal induction of 4 Tesla. The paper will review these choices in the light of what is presently known and examine if better solutions would be possible today for constructing a new large high-field thin solenoid for a future detector magnet.

  4. Investigation with automatic ultrasonic equipment to trace flaws in a large test piece, and experience gained in carrying out inspections

    International Nuclear Information System (INIS)

    Lindner, J.P.

    1975-01-01

    evaluated for the individual parameters of the inspection. Finally, the possibilities are given for employing such inspection equipment for ultrasonic in-service inspections on reactor pressure vessels. A report is given on the experience gained in this respect both for internal and external inspections. (author)

  5. Clinical risk factors for weight gain during psychopharmacologic treatment of depression: results from 2 large German observational studies.

    Science.gov (United States)

    Kloiber, Stefan; Domschke, Katharina; Ising, Marcus; Arolt, Volker; Baune, Bernhard T; Holsboer, Florian; Lucae, Susanne

    2015-06-01

    Weight gain during psychopharmacologic treatment has considerable impact on the clinical management of depression, treatment continuation, and risk for metabolic disorders. As no profound clinical risk factors have been identified so far, the aim of our analyses was to determine clinical risk factors associated with short-term weight development in 2 large observational psychopharmacologic treatment studies for major depression. Clinical variables at baseline (age, gender, depression psychopathology, anthropometry, disease history, and disease entity) were analyzed for association with percent change in body mass index (BMI; normal range, 18.5 to 25 kg/m(2)) during 5 weeks of naturalistic psychopharmacologic treatment in patients who had a depressive episode as single depressive episode, in the course of recurrent unipolar depression or bipolar disorder according to DSM-IV criteria. 703 patients participated in the Munich Antidepressant Response Signature (MARS) project, an ongoing study since 2002, and 214 patients participated in a study conducted at the University of Muenster from 2004 to 2006 in Germany. Lower BMI, weight-increasing side effects of medication, severity of depression, and psychotic symptoms could be identified as clinical risk factors associated with elevated weight gain during the initial treatment phase of 5 weeks in both studies. Based on these results, a composite risk score for weight gain consisting of BMI ≤ 25 kg/m(2), Hamilton Depression Rating Scale (17-item) score > 20, presence of psychotic symptoms, and administration of psychopharmacologic medication with potential weight-gaining side effects was highly discriminative for mean weight gain (F4,909 = 26.77, P = 5.14E-21) during short-term psychopharmacologic treatment. On the basis of our results, depressed patients with low to normal BMI, severe depression, or psychotic symptoms should be considered at higher risk for weight gain during acute antidepressant treatment. We introduce

  6. Parent-Reported Bullying and Child Weight Gain between Ages 6 and 15.

    Science.gov (United States)

    Sutin, Angelina R; Robinson, Eric; Daly, Michael; Terracciano, Antonio

    2016-12-01

    Childhood bullying has long-term negative mental and physical health correlates, including weight gain and symptoms of depression. The purpose of this research is to examine whether bullying in the first year of school is associated with greater weight gain by early adolescence and whether adolescent depressive symptoms mediate this association. Data were drawn from the Longitudinal Study of Australian Children. Children (N = 3929) were measured every 2 years; BMI and waist circumference were available from ages 4 to 15. Parents reported on bullying at age 6. Children reported on their depressive symptoms at ages 12-13. Participants who weighed in the obese category at age 4 had an over 50% increased risk of being bullied in school at age 6. Being bullied at age 6 was associated with excess weight gain between ages 6 and 15, defined as either BMI or waist circumference. Depressive symptoms at age 12 partially explained the association between bullying and increases in adiposity. None of the associations varied by gender. Similar to other forms of peer victimization, bullying early in school is associated with greater weight gain through early adolescence; depressive symptom is one mechanism that contributes to this association.

  7. Report of the large solenoid detector group

    International Nuclear Information System (INIS)

    Hanson, G.G.; Mori, S.; Pondrom, L.G.

    1987-09-01

    This report presents a conceptual design of a large solenoid for studying physics at the SSC. The parameters and nature of the detector have been chosen based on present estimates of what is required to allow the study of heavy quarks, supersymmetry, heavy Higgs particles, WW scattering at large invariant masses, new W and Z bosons, and very large momentum transfer parton-parton scattering. Simply stated, the goal is to obtain optimum detection and identification of electrons, muons, neutrinos, jets, W's and Z's over a large rapidity region. The primary region of interest extends over +-3 units of rapidity, although the calorimetry must extend to +-5.5 units if optimal missing energy resolution is to be obtained. A magnetic field was incorporated because of the importance of identifying the signs of the charges for both electrons and muons and because of the added possibility of identifying tau leptons and secondary vertices. In addition, the existence of a magnetic field may prove useful for studying new physics processes about which we currently have no knowledge. Since hermeticity of the calorimetry is extremely important, the entire central and endcap calorimeters were located inside the solenoid. This does not at the moment seem to produce significant problems (although many issues remain to be resolved) and in fact leads to a very effective muon detector in the central region

  8. Associations of exercise-induced hormone profiles and gains in strength and hypertrophy in a large cohort after weight training.

    Science.gov (United States)

    West, Daniel W D; Phillips, Stuart M

    2012-07-01

    The purpose of this study was to investigate associations between acute exercise-induced hormone responses and adaptations to high intensity resistance training in a large cohort (n = 56) of young men. Acute post-exercise serum growth hormone (GH), free testosterone (fT), insulin-like growth factor (IGF-1) and cortisol responses were determined following an acute intense leg resistance exercise routine at the midpoint of a 12-week resistance exercise training study. Acute hormonal responses were correlated with gains in lean body mass (LBM), muscle fibre cross-sectional area (CSA) and leg press strength. There were no significant correlations between the exercise-induced elevations (area under the curve-AUC) of GH, fT and IGF-1 and gains in LBM or leg press strength. Significant correlations were found for cortisol, usually assumed to be a hormone indicative of catabolic drive, AUC with change in LBM (r = 0.29, P training-induced changes in fibre CSA and LBM (cortisol only), but not with changes in strength.

  9. Gestational weight gain.

    Science.gov (United States)

    Kominiarek, Michelle A; Peaceman, Alan M

    2017-12-01

    Prenatal care providers are advised to evaluate maternal weight at each regularly scheduled prenatal visit, monitor progress toward meeting weight gain goals, and provide individualized counseling if significant deviations from a woman's goals occur. Today, nearly 50% of women exceed their weight gain goals with overweight and obese women having the highest prevalence of excessive weight gain. Risks of inadequate weight gain include low birthweight and failure to initiate breast-feeding whereas the risks of excessive weight gain include cesarean deliveries and postpartum weight retention for the mother and large-for-gestational-age infants, macrosomia, and childhood overweight or obesity for the offspring. Prenatal care providers have many resources and tools to incorporate weight and other health behavior counseling into routine prenatal practices. Because many women are motivated to improve health behaviors, pregnancy is often considered the optimal time to intervene for issues related to eating habits and physical activity to prevent excessive weight gain. Gestational weight gain is a potentially modifiable risk factor for a number of adverse maternal and neonatal outcomes and meta-analyses of randomized controlled trials report that diet or exercise interventions during pregnancy can help reduce excessive weight gain. However, health behavior interventions for gestational weight gain have not significantly improved other maternal and neonatal outcomes and have limited effectiveness in overweight and obese women. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. European Extremely Large Telescope: progress report

    Science.gov (United States)

    Tamai, R.; Spyromilio, J.

    2014-07-01

    The European Extremely Large Telescope is a project of the European Southern Observatory to build and operate a 40-m class optical near-infrared telescope. The telescope design effort is largely concluded and construction contracts are being placed with industry and academic/research institutes for the various components. The siting of the telescope in Northern Chile close to the Paranal site allows for an integrated operation of the facility providing significant economies. The progress of the project in various areas is presented in this paper and references to other papers at this SPIE meeting are made.

  11. 75 FR 21455 - Large Trader Reporting System

    Science.gov (United States)

    2010-04-23

    ... essence, a ``large trader'' would be defined as a person whose transactions in NMS securities equal or... directly or indirectly effect securities transactions.\\14\\ \\12\\ Section 13(h) of the Exchange Act defines a... term ``identifying activity level'' is defined in Section 13(h) as ``transactions in publicly traded...

  12. Summary report on large HVEC accelerators

    International Nuclear Information System (INIS)

    Thieberger, P.

    1981-01-01

    The main features are described of the ten presently operating large HVEC tandem accelerators and of four additional HVEC accelerators which are in different stages of testing, construction or planning. Present performance characteristics are discussed as well as available information about long term reliability. Some recent improvements are mentioned and comparisons are drawn for acceleration tube gradients in various different configurations and accelerators. Finally, some possible future developments are indicated

  13. Living in large experiments - ECFA report

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    The European Committee for Future Accelerators (ECFA) plays an important role in shaping the physics programme in Europe, especially around major facilities which attract increasingly large numbers of users. How happy are physicists working in these scientific Towers of Babel? Apart from making physics discoveries, what are their requirements? Following a suggestion of CERN Director General Chris Llewellyn Smith, to provide an updated answer to these questions ECFA Chairman Gunter Flügge initiated a survey on the sociology of large experiments. It fell to Bjarne Stugu of Bergen, as the youngest member of ECFA, to lead an ECFA subcommittee to carry it out. A similar ECFA survey, carried out back in 1979/80, was influential in preparing infrastructure and thinking for the LEP experimental programme. In the past 20 years, high energy physics collaborations have grown from typically 20 persons at fixed target experiments to around 500 for current major detectors at large colliding beam facilities. The high complexity and cost of the two general-purpose experiments for the LHC require even larger collaborations, approaching 1500. With these two experiments alone - ATLAS and CMS - absorbing a considerable fraction of the entire high energy physics community, it is timely to review the organizational and sociological aspects of large experiments. ECFA recently sent a questionnaire to research groups involved in large collaborations in LEP (CERN), HERA (DESY) and the LHC (CERN). Each group leader was asked to reply, but to get a balanced view, a younger member of the group was also requested to return the form. The replies were anonymous. The questionnaire was distributed to as many groups as possible, and 182 forms were returned. 90 replies from people working at LEP, where the four experiments include 159 groups, corresponds to a response rate of 28.3% with two forms returned. Similarly, 48 replies from the 87 institutions participating in the two main HERA experiments

  14. Massachusetts Large Blade Test Facility Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Rahul Yarala; Rob Priore

    2011-09-02

    Project Objective: The Massachusetts Clean Energy Center (CEC) will design, construct, and ultimately have responsibility for the operation of the Large Wind Turbine Blade Test Facility, which is an advanced blade testing facility capable of testing wind turbine blades up to at least 90 meters in length on three test stands. Background: Wind turbine blade testing is required to meet international design standards, and is a critical factor in maintaining high levels of reliability and mitigating the technical and financial risk of deploying massproduced wind turbine models. Testing is also needed to identify specific blade design issues that may contribute to reduced wind turbine reliability and performance. Testing is also required to optimize aerodynamics, structural performance, encourage new technologies and materials development making wind even more competitive. The objective of this project is to accelerate the design and construction of a large wind blade testing facility capable of testing blades with minimum queue times at a reasonable cost. This testing facility will encourage and provide the opportunity for the U.S wind industry to conduct more rigorous testing of blades to improve wind turbine reliability.

  15. Large bowel leiomyosarcoma - a case report

    International Nuclear Information System (INIS)

    Lopes, Simone Goncalves; Marchiori, Edson; Brick, Julieta Figueiredo; Curty Neto, Eduardo; Scherman, Alexandre; Silva, Ana Carina Gamboa da; Machado, Bruno Beber

    2001-01-01

    The authors report a case of a 49-year-old male patient with leiomyosarcoma of the ascending colon. The patient presented with anemia and an abdominal mass, and the symptoms progressed until a final diagnosis was made nine months later. A plain abdominal x-ray showed the presence of gas outside the bowel, in the right hypochondrium. The double contrast barium enema showed a sublevel displacement of the hepatic flexure and diverticula. An abdominal ultrasound revealed a heterogeneous expansive lesion below the liver containing gas, and a computed tomography of the abdomen revealed an excavated mass below the liver containing liquid, that was not filled by contrast medium. The patient was submitted to a right hemicolectomy with ileocoloanastomosis and the histopathological analysis of the excised material revealed a leiomyosarcoma of the ascending colon. (author)

  16. Association Between Gestational Weight Gain According to Body Mass Index and Postpartum Weight in a Large Cohort of Danish Women

    DEFF Research Database (Denmark)

    Rode, Line; Kjærgaard, Hanne; Ottesen, Bent

    2012-01-01

    weight, 60% of overweight and 50% of obese women gained more than recommended during pregnancy. For normal weight and overweight women with GWG above recommendations the OR of gaining = 5 kg (11 lbs) 1-year postpartum was 2.8 (95% CI 2.0-4.0) and 2.8 (95% CI 1.3-6.2, respectively) compared to women...... with GWG within recommendations. GWG above IOM recommendations significantly increases normal weight, overweight and obese women's risk of retaining weight 1 year after delivery. Health personnel face a challenge in prenatal counseling as 40-60% of these women gain more weight than recommended...

  17. Association between gestational weight gain according to body mass index and postpartum weight in a large cohort of Danish women.

    Science.gov (United States)

    Rode, Line; Kjærgaard, Hanne; Ottesen, Bent; Damm, Peter; Hegaard, Hanne K

    2012-02-01

    Our aim was to investigate the association between gestational weight gain (GWG) and postpartum weight retention (PWR) in pre-pregnancy underweight, normal weight, overweight or obese women, with emphasis on the American Institute of Medicine (IOM) recommendations. We performed secondary analyses on data based on questionnaires from 1,898 women from the "Smoke-free Newborn Study" conducted 1996-1999 at Hvidovre Hospital, Denmark. Relationship between GWG and PWR was examined according to BMI as a continuous variable and in four groups. Association between PWR and GWG according to IOM recommendations was tested by linear regression analysis and the association between PWR ≥ 5 kg (11 lbs) and GWG by logistic regression analysis. Mean GWG and mean PWR were constant for all BMI units until 26-27 kg/m(2). After this cut-off mean GWG and mean PWR decreased with increasing BMI. Nearly 40% of normal weight, 60% of overweight and 50% of obese women gained more than recommended during pregnancy. For normal weight and overweight women with GWG above recommendations the OR of gaining ≥ 5 kg (11 lbs) 1-year postpartum was 2.8 (95% CI 2.0-4.0) and 2.8 (95% CI 1.3-6.2, respectively) compared to women with GWG within recommendations. GWG above IOM recommendations significantly increases normal weight, overweight and obese women's risk of retaining weight 1 year after delivery. Health personnel face a challenge in prenatal counseling as 40-60% of these women gain more weight than recommended for their BMI. As GWG is potentially modifiable, our study should be followed by intervention studies focusing on GW.

  18. Low Birthweight, Rapid Weight Gain and Metabolic Syndrome in Adolescence: An Illustrative Case Report

    Directory of Open Access Journals (Sweden)

    Onyiriuka Alphonsus N.

    2015-12-01

    Full Text Available A 16-year-old boy whose diabetes mellitus was diagnosed 3 months previously in a private hospital but was not placed on medication. The presenting complaints were fast breathing for 24 hours, weakness for 2 hours, and unresponsiveness to calls for 0.5 hours. His father was obese with type 2 diabetes mellitus and died 8 months earlier from cardiac arrest. His birthweight was low, 2.2kg. At first presentation, his weight, BMI and blood pressure were 60kg (25th-50th percentile, 19.4kg/m2 (25thpercentile and 110/70mmHg (systolic BP 50th percentile, diastolic BP 50th-90th percentile, respectively. He was managed for diabetic ketoacidosis and was discharged on subcutaneous premixed insulin, 1 Unit/kg/day. At point of discharge, weight and BP were 60.5 kg and 120/70 mmHg, respectively. The patient defaulted but presented again 6 months later at the age of 17 years. At second presentation, his weight, BMI and BP were 89 kg (95th percentile, 27.5 kg/m2 (90th-95th percentile and 180/80 mmHg (systolic 99th percentile; diastolic 90th percentile, respectively. His waist circumference was 98.7cm (> 90th percentile. We had no record of previous waist circumference. His lipid profile showed low HDL-cholesterol 0.7252 mmol/L [(28mg/dl; <5thpercentile]. His fasting blood glucose and HbA1C were 6.5 mmol/L (117mg/dl and 34 mol/mol (5.3%, respectively. A diagnosis of metabolic syndrome in a patient with ketosis-prone type 2 diabetes was made. He was referred to the pediatric cardiologist for management of his hypertension. He defaulted again and was lost to follow up. Conclusion: This report illustrates the association of low birth weight and rapid weight gain with metabolic syndrome in adolescence.

  19. Audit of Gaining Early Awareness and Readiness for Undergraduate Programs. Final Audit Report.

    Science.gov (United States)

    Office of Inspector General (ED), Washington, DC.

    An audit was conducted to determine whether the U.S. Department of Education had implemented adequate management controls to administer the Gaining Early Awareness and Readiness for Undergraduate Programs (GEAR UP) in accordance with legislative, regulatory, and internal administrative requirements. The focus was on the fiscal year 2000 grant…

  20. Self-reported causes of weight gain: among prebariatric surgery patients.

    Science.gov (United States)

    Ferguson, Sarah; Al-Rehany, Layla; Tang, Cathy; Gougeon, Lorraine; Warwick, Katie; Madill, Janet

    2013-01-01

    Bariatric surgery is accepted by the medical community as the most effective treatment for obesity; however, weight regain after surgery remains common. Long-term weight loss and weight maintenance may be aided when dietitians who provide perioperative care understand the causes of weight gain leading to bariatric surgery. In this study, the most common causes for weight gain were examined among prebariatric surgery patients. A retrospective chart review was conducted for 160 patients enrolled in a bariatric surgery program. Data were collected for 20 variables: puberty, pregnancy, menopause, change in living environment, change in job/career, financial problems, quitting smoking, drug or alcohol use, medical condition, surgery, injury affecting mobility, chronic pain, dieting, others' influence over diet, abuse, mental health condition, stress, death of a loved one, divorce/end of a relationship, and other causes. Frequency distribution and chi-square tests were performed using SPSS. Sixty-three percent of participants selected stress as a cause of weight gain, while 56% selected dieting. Significant differences existed between women and men in the selection of dieting and change in living environment. This information may allow dietitians to better identify causes for weight gain leading to bariatric surgery, and to address these causes appropriately before and after surgery.

  1. Combined Influence of Gestational Weight Gain and Estimated Fetal Weight on Risk Assessment for Small- or Large-for-Gestational-Age Birth Weight: A Prospective Cohort Study.

    Science.gov (United States)

    Pugh, Sarah J; Hinkle, Stefanie N; Kim, Sungduk; Albert, Paul S; Newman, Roger; Grobman, William A; Wing, Deborah A; Grantz, Katherine L

    2018-04-01

    To evaluate the frequency with which gestational weight gain and estimated fetal weight do not track across gestation and to assess the risk of small-for-gestational-age (SGA) and large-for-gestational-age (LGA) birth weight as a function of tracking. This study included a pregnancy cohort (2009-2013) of 2438 women from 4 racial/ethnic groups in the United States. We calculated race- and trimester-specific gestational weight gain and estimated fetal weight z scores. The prevalence of how often gestational weight gain and estimated fetal weight did not or did directly track was examined by grouping z scores into measure-specific categories (1 SD) and then examining 2-measure combinations. Trimester-specific relative risks for SGA and LGA births were estimated with a gestational weight gain and estimated fetal weight z score interaction. We estimated coefficients for selected gestational weight gain and estimated fetal weight values (-1 SD, 0 SD, and +1 SD) compared with the referent of 0 SD for both measures. Small and large for gestational age were calculated as birth weight below the 10th and at or above the 90th percentiles, respectively. Gestational weight gain and estimated fetal weight were within 1 SD 55.5%, 51.5%, and 48.2% of the time in the first, second, and third trimesters, respectively. There was no significant interaction between gestational weight gain and estimated fetal weight on the risk of SGA in the first and second trimesters (interaction term P = .48; P = .79). In the third trimester, there was a significant interaction (P = .002), resulting in a 71% (95% confidence interval, 1.45-2.02) increased risk of SGA when estimated fetal weight was low and gestational weight gain was high. These relationships were similar for the risk of LGA. Deviations in either measure, even in the presence of average gestational weight gain or estimated fetal weight, still suggest an increased risk of SGA and LGA. © 2017 by the American Institute of

  2. Financial conflicts of interest and reporting bias regarding the association between sugar-sweetened beverages and weight gain: a systematic review of systematic reviews.

    Science.gov (United States)

    Bes-Rastrollo, Maira; Schulze, Matthias B; Ruiz-Canela, Miguel; Martinez-Gonzalez, Miguel A

    2013-12-01

    Industry sponsors' financial interests might bias the conclusions of scientific research. We examined whether financial industry funding or the disclosure of potential conflicts of interest influenced the results of published systematic reviews (SRs) conducted in the field of sugar-sweetened beverages (SSBs) and weight gain or obesity. We conducted a search of the PubMed, Cochrane Library, and Scopus databases to identify published SRs from the inception of the databases to August 31, 2013, on the association between SSB consumption and weight gain or obesity. SR conclusions were independently classified by two researchers into two groups: those that found a positive association and those that did not. These two reviewers were blinded with respect to the stated source of funding and the disclosure of conflicts of interest. We identified 17 SRs (with 18 conclusions). In six of the SRs a financial conflict of interest with some food industry was disclosed. Among those reviews without any reported conflict of interest, 83.3% of the conclusions (10/12) were that SSB consumption could be a potential risk factor for weight gain. In contrast, the same percentage of conclusions, 83.3% (5/6), of those SRs disclosing some financial conflict of interest with the food industry were that the scientific evidence was insufficient to support a positive association between SSB consumption and weight gain or obesity. Those reviews with conflicts of interest were five times more likely to present a conclusion of no positive association than those without them (relative risk: 5.0, 95% CI: 1.3-19.3). An important limitation of this study is the impossibility of ruling out the existence of publication bias among those studies not declaring any conflict of interest. However, the best large randomized trials also support a direct association between SSB consumption and weight gain or obesity. Financial conflicts of interest may bias conclusions from SRs on SSB consumption and weight gain

  3. Ytterbium-doped large-mode-area photonic crystal fiber amplifier with gain shaping for use at long wavelengths

    DEFF Research Database (Denmark)

    Petersen, Sidsel Rübner; Alkeskjold, Thomas T.; Poli, Federica

    2012-01-01

    A large-mode-area Ytterbium-doped photonic crystal fiber amplifier with efficient suppression of amplified spontaneous emission is presented. The fiber cladding consists of a hexagonal lattice of air holes, where three rows are replaced with circular high-index inclusions. Seven missing air holes...

  4. Weight gain after bariatric surgery as a result of a large gastric stoma: endotherapy with sodium morrhuate may prevent the need for surgical revision.

    Science.gov (United States)

    Catalano, Marc F; Rudic, Goran; Anderson, Alfred J; Chua, Thomas Y

    2007-08-01

    Obesity affects more than 30% of the U.S. population and is associated with the development of life-threatening complications. Numerous therapeutic approaches to the problem have been advocated, including low-calorie diets, anoretic drugs, behavior modifications, and exercise therapy. The only treatment proven to be effective in the long-term management of morbid obesity is surgical intervention. Complications of bariatric surgery include stomal stenosis and/or ulcer and stomal dilation (secondary to overeating). The latter complication can result in a gain of previously lost weight. To determine the effect of endoscopic injection by using a sclerosant (sodium morrhuate) to induce stomal stenosis in patients who present with stomal dilatation complicated by weight gain. Bariatric patients with a large gastric stoma were treated with sodium morrhuate stomal injection. Diameters of the stoma were followed at repeat endoscopy. Weight loss at scheduled clinic visits were compared with pretherapy weights. Twenty-eight patients (10 men, 18 women; age range, 27-58 years), after bariatric surgery with GI bypass, were referred with weight gain after initial weight loss. Weight gain was believed to be the result of a large gastric stoma. Treatment included injection of sodium morrhuate (1-2 mL circumferentially) surrounding the stoma. A total of 1 to 3 injection sessions were performed in an attempt to achieve a stoma diameter of 1.2 cm or smaller. Treatment success was defined as a decrease of stoma size to weight loss >or=75% of the weight the patient gained after establishing a steady state post bariatric surgery weight. A total of 2.3 injection sessions were performed. Successful endotherapy was achieved in 18 of 28 patients (64%). One patient developed symptoms of stomal stenosis, which required 2 separate balloon dilating sessions. No other complications were encountered. Retrospective case series. Endoscopic injection of sodium morrhuate surrounding the dilated

  5. Associations of exercise-induced hormone profiles and gains in strength and hypertrophy in a large cohort after weight training

    OpenAIRE

    West, Daniel W. D.; Phillips, Stuart M.

    2011-01-01

    The purpose of this study was to investigate associations between acute exercise-induced hormone responses and adaptations to high intensity resistance training in a large cohort (n = 56) of young men. Acute post-exercise serum growth hormone (GH), free testosterone (fT), insulin-like growth factor (IGF-1) and cortisol responses were determined following an acute intense leg resistance exercise routine at the midpoint of a 12-week resistance exercise training study. Acute hormonal responses w...

  6. Development of sub-nanosecond, high gain structures for time-of-flight ring imaging in large area detectors

    International Nuclear Information System (INIS)

    Wetstein, Matthew

    2011-01-01

    Microchannel plate photomultiplier tubes (MCPs) are compact, imaging detectors, capable of micron-level spatial imaging and timing measurements with resolutions below 10 ps. Conventional fabrication methods are too expensive for making MCPs in the quantities and sizes necessary for typical HEP applications, such as time-of-flight ring-imaging Cherenkov detectors (TOF-RICH) or water Cherenkov-based neutrino experiments. The Large Area Picosecond Photodetector Collaboration (LAPPD) is developing new, commercializable methods to fabricate 20 cm 2 thin planar MCPs at costs comparable to those of traditional photo-multiplier tubes. Transmission-line readout with waveform sampling on both ends of each line allows the efficient coverage of large areas while maintaining excellent time and space resolution. Rather than fabricating channel plates from active, high secondary electron emission materials, we produce plates from passive substrates, and coat them using atomic layer deposition (ALD), a well established industrial batch process. In addition to possible reductions in cost and conditioning time, this allows greater control to optimize the composition of active materials for performance. We present details of the MCP fabrication method, preliminary results from testing and characterization facilities, and possible HEP applications.

  7. Weight Gain during Pregnancy

    Science.gov (United States)

    ... Global Map Premature Birth Report Cards Careers Archives Pregnancy Before or between pregnancies Nutrition, weight & fitness Prenatal ... fitness > Weight gain during pregnancy Weight gain during pregnancy E-mail to a friend Please fill in ...

  8. Purulent Pericarditis Caused by Streptococcus Milleri Strains; the Gained Experience from Nine Reported Cases

    Directory of Open Access Journals (Sweden)

    Ilias A. Kouerinis

    2015-12-01

    Full Text Available Bacterial pericarditis caused by Streptococcus Milleri Group (SMG strains is a particularly exceptional pathology. All the eight previous reported cases were under the care of medical teams and the seven existed reports in medical journals were more or less from this perspective. Herein, we reported a unique case of a pericardial-cutaneous fistula resulting from a recurrent purulent pericardial effusion caused by SMG strains, which had been treated with open surgical drainage two months before. A thorough review of the surgical treatment options and the results has also been presented.

  9. Clinical attachment level gain and three-year maintenance of a maxillary incisor with 100% bone loss: A case report.

    Science.gov (United States)

    Tirone, Federico; Salzano, Stefano

    2016-01-01

    This case report discusses a patient suffering from chronic periodontal disease and diagnosed with a hopeless central incisor. The intention was to show the possibility of gaining new clinical attachment via regenerative surgery in a tooth with 100% bone loss around the root. Treatment of hopeless and questionable teeth in periodontal patients has become an ideological matter. On the one hand, dental implants have proved to be a reliable solution to replace lost teeth; on the other hand, newly emerging evidence suggests that successful periodontal treatment of teeth diagnosed as hopeless is possible. Here we describe surgical, orthodontic, and restorative treatments that led to clinical attachment gain and achieved clinical success over a three-year follow-up period.

  10. Report of the LASCAR forum: Large scale reprocessing plant safeguards

    International Nuclear Information System (INIS)

    1992-01-01

    This report has been prepared to provide information on the studies which were carried out from 1988 to 1992 under the auspices of the multinational forum known as Large Scale Reprocessing Plant Safeguards (LASCAR) on safeguards for four large scale reprocessing plants operated or planned to be operated in the 1990s. The report summarizes all of the essential results of these studies. The participants in LASCAR were from France, Germany, Japan, the United Kingdom, the United States of America, the Commission of the European Communities - Euratom, and the International Atomic Energy Agency

  11. Technical advisory panel for the large acceptance spectrometer: Final report

    International Nuclear Information System (INIS)

    1989-01-01

    The Technical Advisory Panel for the Large Acceptance Spectrometer met on November 17--19, 1988, at CEBAF to perform a second review of the status of this project. The charge to the Panel was ''to provide technical advice to the CEBAF directorate on the design, construction, cost, schedule, and implementation of the Large Acceptance Spectrometer.'' In this written report, an overview of the entire project is given. Specific comments on the major components, data handling and analysis, assembly and installation, and management are presented. The Panel's conclusions are contained in the Executive Summary at the beginning of the report

  12. Unusually large erupted complex odontoma: A rare case report

    Energy Technology Data Exchange (ETDEWEB)

    Bagewadi, Shivanand B.; Kukreja, Rahul; Suma, Gundareddy N.; Yadav, Bhawn; Sharma, Havi [Dept. of Oral Medicine and Radiology, ITS Centre for Dental Studies and Research, Murad Nagar (India)

    2015-03-15

    Odontomas are nonaggressive, hamartomatous developmental malformations composed of mature tooth substances and may be compound or complex depending on the extent of morphodifferentiation or on their resemblance to normal teeth. Among them, complex odontomas are relatively rare tumors. They are usually asymptomatic in nature. Occasionally, these tumors become large, causing bone expansion followed by facial asymmetry. Odontoma eruptions are uncommon, and thus far, very few cases of erupted complex odontomas have been reported in the literature. Here, we report the case of an unusually large, painless, complex odontoma located in the right posterior mandible.

  13. Power fluctuations from large wind farms - Final report

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, Poul; Pinson, P.; Cutululis, N.A.; Madsen, Henrik; Jensen, Leo Enrico; Hjerrild, J.; Heyman Donovan, M.; Vigueras-ROdriguez, A.

    2009-08-15

    Experience from power system operation with the first large offshore wind farm in Denmark: Horns Rev shows that the power from the wind farm is fluctuating significantly at certain times, and that this fluctuation is seen directly on the power exchange between Denmark and Germany. This report describes different models for simulation and prediction of wind power fluctuations from large wind farms, and data acquired at the two large offshore wind farms in Denmark are applied to validate the models. Finally, the simulation model is further developed to enable simulations of power fluctuations from several wind farms simultaneously in a larger geographical area, corresponding to a power system control area. (au)

  14. 105-DR Large Sodium Fire Facility closure activities evaluation report

    International Nuclear Information System (INIS)

    Adler, J.G.

    1996-01-01

    This report evaluates the closure activities at the 105-DR Large Sodium Fire Facility. The closure activities discussed include: the closure activities for the structures, equipment, soil, and gravel scrubber; decontamination methods; materials made available for recycling or reuse; and waste management. The evaluation compares these activities to the regulatory requirements and closure plan requirements. The report concludes that the areas identified in the closure plan can be clean closed

  15. Ichthyosiform large plaque parapsoriasis: report of a rare entity.

    Science.gov (United States)

    Nag, Falguni; Ghosh, Arghyaprasun; Biswas, Projna; Chatterjee, Gobinda; Biswas, Saugato

    2013-09-01

    Large plaque parapsoriasis (LPP) is an idiopathic, chronic scaly dermatosis classified within parapsoriasis group of diseases, occurring commonly in middle aged patients of all races and geographic regions. LPP and its variants are closely related to the patch stage of mycosis fungoides. The two types of LPP mostly described are the poikilodermatous and retiform parapsoriasis. We are reporting an ichthyosiform LPP for its rarity.

  16. An infant with poor weight gain and hypochloremic metabolic alkalosis: a case report

    Directory of Open Access Journals (Sweden)

    Alhammadi AH

    2014-07-01

    Full Text Available Ahmed H Alhammadi, Mohamed Khalifa, Lolwa Alnaimi Department of Pediatrics, Division of General Pediatrics, Hamad Medical Corporation, Doha, Qatar Abstract: Bartter syndrome is an autosomal recessive disease manifested by a defect in chloride transport in the thick loop of Henle, with different genetic origins and molecular pathophysiology. Children with Bartter syndrome generally present in early infancy with persistent polyuria and associated dehydration, electrolyte imbalance, and failure to thrive. Although early diagnosis and appropriate treatment of Bartter syndrome may improve the outcome, some children will progress to renal failure. We report a case of an 8-week-old infant who was admitted for electrolyte imbalance and failure to thrive. Laboratory studies revealed hypochloremic metabolic alkalosis with severe hypokalemia. Health care providers should consider Bartter syndrome when excessive chloride losses appear to be renal in origin and the patient has normal blood pressure and high levels of serum renin and aldosterone. Treatments, including indomethacin, spironolactone, and aggressive fluid and electrolyte replacement, may prevent renal failure in children with Bartter syndrome. Molecular genetics studies are indicated to identify the primary genetic defect. Keywords: Bartter syndrome, failure to thrive, metabolic alkalosis 

  17. Large oral lipoma: Case report and literature review in Iran

    Directory of Open Access Journals (Sweden)

    Ahmad Motagi

    2012-01-01

    Full Text Available Lipoma is a benign mesenchymal tumor of fat with uncertain pathogenesis. Although the most common mesenchymal neoplasm in trunk and proximal portions of the extremities, it is rarely seen in the oral cavity. Oral lipomas are clinically soft, smooth-surfaced nodular masses that mostly are less than 3 cm in size. Typically the tumor is asymptomatic unless bitten or become noticeable because of their size. The buccal mucosa and buccal vestibule are the most common intraoral sites and account for 50% of all cases. Reported here is a relatively large lipoma of buccal mucosa that was treated surgically under local anesthesia. In an 18-month postsurgical follow up no complication or recurrence has occurred. This case will also be compared to intraoral lipomas reported in Iranian population. As lipomas are usually smaller than 3 cm in diameter, lipoma with the size reported, is of clinical importance. Since the large lipomas are in differential diagnosis with other, even malignant, mesenchymal, or salivary gland tumors. Thus, this case report recommends clinical awareness in diagnosis of large intraoral soft tissue lesions.

  18. Report from the 4th Workshop on Extremely Large Databases

    Directory of Open Access Journals (Sweden)

    Jacek Becla

    2011-02-01

    Full Text Available Academic and industrial users are increasingly facing the challenge of petabytes of data, but managing and analyzing such large data sets still remains a daunting task. The 4th Extremely Large Databases workshop was organized to examine the needs of communities under-represented at the past workshops facing these issues. Approaches to big data statistical analytics as well as emerging opportunities related to emerging hardware technologies were also debated. Writable extreme scale databases and the science benchmark were discussed. This paper is the final report of the discussions and activities at this workshop.

  19. Report from the 2nd Workshop on Extremely Large Databases

    Directory of Open Access Journals (Sweden)

    Jacek Becla

    2009-03-01

    Full Text Available The complexity and sophistication of large scale analytics in science and industry have advanced dramatically in recent years. Analysts are struggling to use complex techniques such as time series analysis and classification algorithms because their familiar, powerful tools are not scalable and cannot effectively use scalable database systems. The 2nd Extremely Large Databases (XLDB workshop was organized to understand these issues, examine their implications, and brainstorm possible solutions. The design of a new open source science database, SciDB that emerged from the first workshop in this series was also debated. This paper is the final report of the discussions and activities at this workshop.

  20. Report from the 3rd Workshop on Extremely Large Databases

    Directory of Open Access Journals (Sweden)

    Jacek Becla

    2010-02-01

    Full Text Available Academic and industrial users are increasingly facing the challenge of petabytes of data, but managing and analyzing such large data sets still remains a daunting task. Both the database and the map/reduce communities worldwide are working on addressing these issues. The 3rdExtremely Large Databases workshop was organized to examine the needs of scientific communities beginning to face these issues, to reach out to European communities working on extremely large scale data challenges, and to brainstorm possible solutions. The science benchmark that emerged from the 2nd workshop in this series was also debated. This paper is the final report of the discussions and activities at this workshop.

  1. Ichthyosiform large plaque parapsoriasis: Report of a rare entity

    Directory of Open Access Journals (Sweden)

    Falguni Nag

    2013-01-01

    Full Text Available Large plaque parapsoriasis (LPP is an idiopathic, chronic scaly dermatosis classified within parapsoriasis group of diseases, occurring commonly in middle aged patients of all races and geographic regions. LPP and its variants are closely related to the patch stage of mycosis fungoides. The two types of LPP mostly described are the poikilodermatous and retiform parapsoriasis. We are reporting an ichthyosiform LPP for its rarity.

  2. Seismic and source characteristics of large chemical explosions. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Adushkin, V.V.; Kostuchenko, V.N.; Pernik, L.M.; Sultanov, D.D.; Zcikanovsky, V.I.

    1995-01-01

    From the very beginning of its arrangement in 1947, the Institute for Dynamics of the Geospheres RAS (former Special Sector of the Institute for physics of the Earth, RAS) was providing scientific observations of effects of nuclear explosions, as well as large-scale detonations of HE, on environment. This report presents principal results of instrumental observations obtained from various large-scale chemical explosions conducted in the Former-Soviet Union in the period of time from 1957 to 1989. Considering principal aim of the work, tamped and equivalent chemical explosions have been selected with total weights from several hundreds to several thousands ton. In particular, the selected explosions were aimed to study scaling law from excavation explosions, seismic effect of tamped explosions, and for dam construction for hydropower stations and soil melioration. Instrumental data on surface explosions of total weight in the same range aimed to test military technics and special objects are not included.

  3. Large Lipoma of the Larynx: A Case Report

    Directory of Open Access Journals (Sweden)

    Mohammad Taghi Khorsandi Ashtiani

    2010-09-01

    Full Text Available "nFewer than 15% of lipomas occur in the head and neck. Lipomas of the larynx are very rare benign laryngeal tumors (0.6%. To date less than 100 case of laryngeal lipoma have been reported in the literature.Clinical manifestation include progressive horseness, dyspnea, and even dysphagia. In the direct exam smooth or pedunculated mass is seen in the larynx and sometimes if tumor is large enough a mass palpated in the neck. In the computed tomography (CT low attenuation mass is seen. Treatment of laryngeal lipoma consists of endoscopic removal or external surgical approach depending on tumor size. The authors present a case of laryngeal lipoma that involved the true vocal cord. The following is a report of a single case of laryngeal lipoma, Including esteroboscopy, radiologic and intraoperative finding as well as review of the literature.

  4. Large Lipoma of the Larynx: A Case Report

    Directory of Open Access Journals (Sweden)

    Mohammad Taghi Khorsandi Ashtiani

    2010-10-01

    Full Text Available Fewer than 15% of lipomas occur in the head and neck. Lipomas of the larynx are very rare benign laryngeal tumors (0.6%. To date less than 100 case of laryngeal lipoma have been reported in the literature.Clinical manifestation include progressive horseness, dyspnea, and even dysphagia. In the direct exam smooth or pedunculated mass is seen in the larynx and sometimes if tumor is large enough a mass palpated in the neck. In the computed tomography (CT low attenuation mass is seen. Treatment of laryngeal lipoma consists of endoscopic removal or external surgical approach depending on tumor size. The authors present a case of laryngeal lipoma that involved the true vocal cord. The following is a report of a single case of laryngeal lipoma, Including esteroboscopy, radiologic and intraoperative finding as well as review of the literature.

  5. How much is too much assessment? Insight into assessment-driven student learning gains in large-scale undergraduate microbiology courses.

    Science.gov (United States)

    Wang, Jack T H; Schembri, Mark A; Hall, Roy A

    2013-01-01

    Designing and implementing assessment tasks in large-scale undergraduate science courses is a labor-intensive process subject to increasing scrutiny from students and quality assurance authorities alike. Recent pedagogical research has provided conceptual frameworks for teaching introductory undergraduate microbiology, but has yet to define best-practice assessment guidelines. This study assessed the applicability of Biggs' theory of constructive alignment in designing consistent learning objectives, activities, and assessment items that aligned with the American Society for Microbiology's concept-based microbiology curriculum in MICR2000, an introductory microbiology course offered at the University of Queensland, Australia. By improving the internal consistency in assessment criteria and increasing the number of assessment items explicitly aligned to the course learning objectives, the teaching team was able to efficiently provide adequate feedback on numerous assessment tasks throughout the semester, which contributed to improved student performance and learning gains. When comparing the constructively aligned 2011 offering of MICR2000 with its 2010 counterpart, students obtained higher marks in both coursework assignments and examinations as the semester progressed. Students also valued the additional feedback provided, as student rankings for course feedback provision increased in 2011 and assessment and feedback was identified as a key strength of MICR2000. By designing MICR2000 using constructive alignment and iterative assessment tasks that followed a common set of learning outcomes, the teaching team was able to effectively deliver detailed and timely feedback in a large introductory microbiology course. This study serves as a case study for how constructive alignment can be integrated into modern teaching practices for large-scale courses.

  6. The effect of holiday weight gain on body weight.

    Science.gov (United States)

    Schoeller, Dale A

    2014-07-01

    The topic of holiday weight gain has been a frequent subject of the lay media; however, scientific interest has only been recent. Multiple studies in Western societies have reported average weight gains among adults during the period between mid-November and mid-January that were about 0.5 kg. The range in individual weight changes was large, however, and the already overweight and obese gain more weight than those who are healthy weight. When the average gain across the year was also measured, the holiday weight was the major contributor to annual excess weight gain. Efforts patterned to increase awareness to energy balance and body weight have been shown to be successful at reducing such gain. An exception to holiday weight gain being a major contributor to annual excess gain has been children, in whom summer weight gains have been observed to be the major contributor to average excess weight gain. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Reversal of olanzapine-induced weight gain in a patient with schizophrenia by switching to asenapine: a case report

    Directory of Open Access Journals (Sweden)

    Okazaki K

    2017-11-01

    Full Text Available Kosuke Okazaki, Kazuhiko Yamamuro, Toshifumi Kishimoto Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan Aims: Antipsychotics are effective for treating schizophrenia, but atypical antipsychotics can cause several adverse side effects including weight gain, hyperprolactinemia, and extrapyramidal symptoms. Moreover, weight gain increases the risk of metabolic diseases.Methods: We treated a case of olanzapine-induced weight gain in a 41-year-old man with schizophrenia by switching his medication from olanzapine to asenapine.Results: The weight gain improved after switching the medication, from 80.3 to 75.0 kg, a weight loss of 6.6%, and there was no significant worsening of psychological symptoms or other adverse effects.Conclusions: Asenapine might be effective for treating patients with schizophrenia who experience olanzapine-induced weight gain. Keywords: olanzapine, weight gain, schizophrenia, asenapine

  8. Reversal of olanzapine-induced weight gain in a patient with schizophrenia by switching to asenapine: a case report

    OpenAIRE

    Okazaki, Kosuke; Yamamuro, Kazuhiko; Kishimoto, Toshifumi

    2017-01-01

    Kosuke Okazaki, Kazuhiko Yamamuro, Toshifumi Kishimoto Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan Aims: Antipsychotics are effective for treating schizophrenia, but atypical antipsychotics can cause several adverse side effects including weight gain, hyperprolactinemia, and extrapyramidal symptoms. Moreover, weight gain increases the risk of metabolic diseases.Methods: We treated a case of olanzapine-induced weight gain in a 41-year-old man with s...

  9. Unusually large solitary unicameral bone cyst: case report.

    Science.gov (United States)

    Singh, Sandeep; Dhammi, Ish Kumar; Arora, Anil; Kumar, Sudhir

    2003-01-01

    A 15-year-old boy presented with complaints of pain and swelling of the right leg. Radiography revealed a large lytic lesion involving the proximal half of the tibia. The patient was taken to surgery, where the cavity was curetted and packed with allogeneic bone graft. Tissue was sent for histopathological evaluation. The patient was kept in an above-knee cast for 4 months, after which partial weight-bearing was allowed. The histopathological diagnosis was a unicameral bone cyst. A radiograph at 1 year showed incorporation of the graft, but a small part of the cavity was still visible and there was a persistent discharge. The patient was again subjected to allogeneic bone grafting in the remaining cavity. At 3.5 years of follow-up now, the patient is walking unsupported, there is no pain, and the radiograph shows complete obliteration of the cavity. Unicameral bone cysts are usually a few centimeters in size. To the best of our knowledge, a unicameral bone cyst of such a large size has never been reported in the literature.

  10. The Benefits of Multi-Year Research Experiences: Differences in Novice and Experienced Students’ Reported Gains from Undergraduate Research

    Science.gov (United States)

    Thiry, Heather; Weston, Timothy J.; Laursen, Sandra L.; Hunter, Anne-Barrie

    2012-01-01

    This mixed-methods study explores differences in novice and experienced undergraduate students’ perceptions of their cognitive, personal, and professional gains from engaging in scientific research. The study was conducted in four different undergraduate research (UR) programs at two research-extensive universities; three of these programs had a focus on the biosciences. Seventy-three entry-level and experienced student researchers participated in in-depth, semi-structured interviews and completed the quantitative Undergraduate Research Student Self-Assessment (URSSA) instrument. Interviews and surveys assessed students’ developmental outcomes from engaging in UR. Experienced students reported distinct personal, professional, and cognitive outcomes relative to their novice peers, including a more sophisticated understanding of the process of scientific research. Students also described the trajectories by which they developed not only the intellectual skills necessary to advance in science, but also the behaviors and temperament necessary to be a scientist. The findings suggest that students benefit from multi-year UR experiences. Implications for UR program design, advising practices, and funding structures are discussed. PMID:22949423

  11. Large scale photovoltaic field trials. Second technical report: monitoring phase

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-09-15

    This report provides an update on the Large-Scale Building Integrated Photovoltaic Field Trials (LS-BIPV FT) programme commissioned by the Department of Trade and Industry (Department for Business, Enterprise and Industry; BERR). It provides detailed profiles of the 12 projects making up this programme, which is part of the UK programme on photovoltaics and has run in parallel with the Domestic Field Trial. These field trials aim to record the experience and use the lessons learnt to raise awareness of, and confidence in, the technology and increase UK capabilities. The projects involved: the visitor centre at the Gaia Energy Centre in Cornwall; a community church hall in London; council offices in West Oxfordshire; a sports science centre at Gloucester University; the visitor centre at Cotswold Water Park; the headquarters of the Insolvency Service; a Welsh Development Agency building; an athletics centre in Birmingham; a research facility at the University of East Anglia; a primary school in Belfast; and Barnstable civic centre in Devon. The report describes the aims of the field trials, monitoring issues, performance, observations and trends, lessons learnt and the results of occupancy surveys.

  12. The Independent Importance of Pre-pregnancy Weight and Gestational Weight Gain for the Prevention of Large-for Gestational Age Brazilian Newborns.

    Science.gov (United States)

    Mastroeni, Marco F; Czarnobay, Sandra A; Kroll, Caroline; Figueirêdo, Katherinne B W; Mastroeni, Silmara S B S; Silva, Jean C; Khan, Mohammad K A; Loehr, Sarah; Veugelers, Paul J

    2017-04-01

    Objectives To study the independent effect of pre-pregnancy weight, gestational weight gain (GWG), and other important risk factors on newborn birth weight. Methods Baseline data of 435 adult women and their singletons born between January and February 2012 at a public hospital in Brazil were used. Logistic regression was applied to determine the independent importance of pre-pregnancy weight and GWG for large for gestational age (LGA) newborns. Results Among all mothers, 37.9 % were overweight and obese before pregnancy and 45.3 % experienced excessive GWG. Among the newborns, 24.4 % were classified as LGA. Univariate analysis showed an association of family income, GWG, pre-pregnancy BMI and excessive GWG with LGA newborns. Smoking before and during pregnancy was associated with a decreased likelihood of giving birth to an LGA newborn compared to mothers who did not smoke. After adjustment for confounding variables, age at birth of first child, GWG, HbA1c and pre-pregnancy weight-GWG were significant and independent determinants of giving birth to an LGA newborn. Mothers with pre-pregnancy overweight and excessive GWG were more likely to deliver an LGA newborn (OR 2.54, P weight and experienced adequate GWG. Conclusions for Practice Age at first birth of child, GWG, HbA1c and pre-pregnancy overweight combined with excessive GWG are independent determinants of LGA newborns. The results of this study suggest that both primary prevention of overweight in women of childbearing age and management of GWG may be important strategies to reduce the number of LGA newborns and, consequently, the long-term public health burden of obesity.

  13. A very large leiomyoma of the urethra: a case report.

    Science.gov (United States)

    Fedelini, Paolo; Chiancone, Francesco; Fedelini, Maurizio; Fabiano, Marco; Persico, Francesco; Di Lorenzo, Domenico; Meccariello, Clemente

    2017-02-28

    Leiomyomas are benign mesenchymal tumours of smooth muscle origin. They are the most common uterine masses in women of reproductive age group and may be related to the hormonal status. Urethral leiomyomas are very rare. According to the literature, the mean diameter of the urethral leiomyomas is 3.7 cm. We report a case of a very large leiomyoma of the urethra. A 40-year-old women woman was admitted to our department for a giant vaginal mass. She complained of haematuria, dysuria, recurrent urinary tract infections and dyspareunia. The physical evaluation demonstrated a 6 × 5.5 cm neoformation involving the distal tract of the urethra. The patient underwent an ultrasonography and then a magnetic resonance that suggested the diagnosis of leiomyoma. The neoformation was excised through a suburethral incision. The patient was discharged after 3 days and no intraoperative and postoperative complications occurred. The Foley catheter was removed after a week. The patient was continent to urine, and at 6 months follow-up, the patient was symptom free and no recurrences occurred.

  14. Unaware of a large leiomyoma: A case report with respect to unusual symptoms of large leiomyomas

    Directory of Open Access Journals (Sweden)

    Barış Mülayim

    2015-12-01

    Conclusion: Patients might have no symptoms or might be unaware of the presence of a large uterine leiomyoma, as in our case; however, large leiomyomas have various unusual symptoms in addition to the common ones. These symptoms should not be disregarded or underestimated.

  15. Experience Gained from Construction of Low-Emission Combustion Chambers for On-Land Large-Capacity Gas-Turbine Units: GT24/26

    Science.gov (United States)

    Bulysova, L. A.; Vasil'ev, V. D.; Berne, A. L.; Gutnik, M. M.

    2018-06-01

    This article is the third in a planned series of articles devoted to the experience gained around the world in constructing low-emission combustion chambers for on-land large-capacity (above 250 MW) gas-turbine units (GTUs). The aim of this study is to generalize and analyze the ways in which different designers apply the fuel flow and combustion arrangement principles and the fuel feed control methods. The considered here GT24 and GT26 (GT24/26) gas-turbine units generating electric power at the 60 and 50 Hz frequencies, respectively, are fitted with burners of identical designs. Designed by ABB, these GTUs were previously manufactured by Alstom, and now they are produced by Ansaldo Energia. The efficiency of these GTUs reaches 41% at the 354 MW power output during operation in the simple cycle and 60.5% at the 505MW power output during operation in the combined cycle. Both GTUs comply with all requirements for harmful emissions. The compression ratio is equal to 35. In this article, a system is considered for two-stage fuel combustion in two sequentially arranged low-emission combustion chambers, one of which is placed upstream of the high-pressure turbine (CC1) and the other upstream of the low-pressure turbine (CC2). The article places the main focus on the CC2, which operates with a decreased content of oxygen in the oxidizer supplied to the burner inlets. The original designs of vortex generators and nozzles placed in the flow of hot combustion products going out from the high-pressure turbine are described in detail. The article also presents an original CC2 front plate cooling system, due to which a significantly smaller amount of air fed for cooling has been reached. The article also presents the pressure damping devices incorporated in the chamber, the use of which made it possible to obtain a significantly wider range of CC loads at which its low-emission operation is ensured. The fuel feed adjustment principles and the combustion control methods

  16. Framework for Assessing Dynamic Nuclear Energy Systems for Sustainability: Final Report of the INPRO Collaborative Project GAINS

    International Nuclear Information System (INIS)

    2013-01-01

    One of the IAEA's statutory objectives is to 'seek to accelerate and enlarge the contribution of atomic energy to peace, health and prosperity throughout the world.' One way this objective is achieved is through the publication of a range of technical series. Two of these are the IAEA Nuclear Energy Series and the IAEA Safety Standards Series. According to Article III.A.6 of the IAEA Statute, the safety standards establish 'standards of safety for protection of health and minimization of danger to life and property'. The safety standards include the Safety Fundamentals, Safety Requirements and Safety Guides. These standards are written primarily in a regulatory style, and are binding on the IAEA for its own programmes. The principal users are the regulatory bodies in Member States and other national authorities. The IAEA Nuclear Energy Series comprises reports designed to encourage and assist R and D on, and application of, nuclear energy for peaceful uses. This includes practical examples to be used by owners and operators of utilities in Member States, implementing organizations, academia, and government officials, among others. This information is presented in guides, reports on technology status and advances, and best practices for peaceful uses of nuclear energy based on inputs from international experts. The IAEA Nuclear Energy Series complements the IAEA Safety Standards Series. As an integral part of Phase 2 of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO), several collaborative projects (CPs) were established by INPRO members. The CP, 'Global Architecture of Innovative Nuclear Energy Systems Based on Thermal and Fast Reactors Including a Closed Fuel Cycle (GAINS)', was one of them. This CP was jointly implemented in 2008-2011 by Belgium, Canada, China, the Czech Republic, France, India, Italy, Japan, the Republic of Korea, the Russian Federation, Slovakia, Ukraine, the United States of America and the European Commission

  17. 76 FR 43851 - Large Trader Reporting for Physical Commodity Swaps

    Science.gov (United States)

    2011-07-22

    ... aware that a reporting level of one contract could potentially expand the Reporting Rules' books and... (December 2, 2010); and letter from Robert Pollin, Professor of Economics and Co-Director, and James Heintz... the threshold reporting level should be 25 contracts instead of the 50-contract threshold specified in...

  18. Underrepresented minority high school and college students report STEM-pipeline sustaining gains after participating in the Loma Linda University Summer Health Disparities Research Program.

    Directory of Open Access Journals (Sweden)

    Lorena M Salto

    Full Text Available An urgent need exists for graduate and professional schools to establish evidence-based STEM (science, technology, engineering, and math pipeline programs to increase the diversity of the biomedical workforce. An untapped yet promising pool of willing participants are capable high school students that have a strong STEM interest but may lack the skills and the guided mentoring needed to succeed in competitive STEM fields. This study evaluates and compares the impact of the Loma Linda University (LLU Summer Health Disparities Research Program on high school (HS and undergraduate (UG student participants. The primary focus of our summer research experience (SRE is to enhance the research self-efficacy of the participants by actively involving them in a research project and by providing the students with personalized mentoring and targeted career development activities, including education on health disparities. The results of our study show that our SRE influenced terminal degree intent and increased participant willingness to incorporate research into future careers for both the HS and the UG groups. The quantitative data shows that both the HS and the UG participants reported large, statistically significant gains in self-assessed research skills and research self-efficacy. Both participant groups identified the hands-on research and the mentor experience as the most valuable aspects of our SRE and reported increased science skills, increased confidence in science ability and increased motivation and affirmation to pursue a science career. The follow-up data indicates that 67% of the HS participants and 90% of the UG participants graduated from college with a STEM degree; for those who enrolled in graduate education, 61% and 43% enrolled in LLU, respectively. We conclude that structured SREs can be highly effective STEM strengthening interventions for both UG and HS students and may be a way to measurably increase institutional and biomedical

  19. Report from the 5th Workshop on Extremely Large Databases

    Directory of Open Access Journals (Sweden)

    Jacek Becla

    2012-03-01

    Full Text Available The 5th XLDB workshop brought together scientific and industrial users, developers, and researchers of extremely large data and focused on emerging challenges in the healthcare and genomics communities, spreadsheet-based large scale analysis, and challenges in applying statistics to large scale analysis, including machine learning. Major problems discussed were the lack of scalable applications, the lack of expertise in developing solutions, the lack of respect for or attention to big data problems, data volume growth exceeding Moore's Law, poorly scaling algorithms, and poor data quality and integration. More communication between users, developers, and researchers is sorely needed. A variety of future work to help all three groups was discussed, ranging from collecting challenge problems to connecting with particular industrial or academic sectors.

  20. Large twisted ovarian fibroma in menopausal women: a case report ...

    African Journals Online (AJOL)

    Ovarian fibroma is the most common benign solid tumors of the ovary, commonly misdiagnosed as uterine fibromaor as malignant ovarian tumors. It occurs generally in older perimenopausal and postmenopausal women. Occasionally large fibromas may undergo torsion causing acute abdominal pain. Doppler ...

  1. Gaining control

    NARCIS (Netherlands)

    Enden, van der E.; Laan, van der R.

    2008-01-01

    The article reports on the efforts of companies to find a solution for tax risk management, tax accounting and being in control. In trying to find a solution, companies work towards an integrated tax control framework (TCF), a tax risk management and control environment embedded in the internal

  2. Advanced Large Area Plastic Scintillator Project (ALPS): Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Jordan, David V.; Reeder, Paul L.; Todd, Lindsay C.; Warren, Glen A.; McCormick, Kathleen R.; Stephens, Daniel L.; Geelhood, Bruce D.; Alzheimer, James M.; Crowell, Shannon L.; Sliger, William A.

    2008-02-05

    The advanced Large-Area Plastic Scintillator (ALPS) Project at Pacific Northwest National Laboratory investigated possible technological avenues for substantially advancing the state-of-the-art in gamma-ray detection via large-area plastic scintillators. The three predominant themes of these investigations comprised the following: * Maximizing light collection efficiency from a single large-area sheet of plastic scintillator, and optimizing hardware event trigger definition to retain detection efficiency while exploiting the power of coincidence to suppress single-PMT "dark current" background; * Utilizing anti-Compton vetoing and supplementary spectral information from a co-located secondary, or "Back" detector, to both (1) minimize Compton background in the low-energy portion of the "Front" scintillator's pulse-height spectrum, and (2) sharpen the statistical accuracy of the front detector's low-energy response prediction as impelmented in suitable energy-windowing algorithms; and * Investigating alternative materials to enhance the intrinsic gamma-ray detection efficiency of plastic-based sensors.

  3. Advanced Large Area Plastic Scintillator Project (ALPS): Final Report

    International Nuclear Information System (INIS)

    Jordan, David V.; Reeder, Paul L.; Todd, Lindsay C.; Warren, Glen A.; McCormick, Kathleen R.; Stephens, Daniel L.; Geelhood, Bruce D.; Alzheimer, James M.; Crowell, Shannon L.; Sliger, William A.

    2008-01-01

    The advanced Large-Area Plastic Scintillator (ALPS) Project at Pacific Northwest National Laboratory investigated possible technological avenues for substantially advancing the state-of-the-art in gamma-ray detection via large-area plastic scintillators. The three predominant themes of these investigations comprised the following: * Maximizing light collection efficiency from a single large-area sheet of plastic scintillator, and optimizing hardware event trigger definition to retain detection efficiency while exploiting the power of coincidence to suppress single-PMT 'dark current' background; * Utilizing anti-Compton vetoing and supplementary spectral information from a co-located secondary, or 'Back' detector, to both (1) minimize Compton background in the low-energy portion of the 'Front' scintillator's pulse-height spectrum, and (2) sharpen the statistical accuracy of the front detector's low-energy response prediction as implemented in suitable energy-windowing algorithms; and * Investigating alternative materials to enhance the intrinsic gamma-ray detection efficiency of plastic-based sensors

  4. Large scale PV plants - also in Denmark. Project report

    Energy Technology Data Exchange (ETDEWEB)

    Ahm, P [PA Energy, Malling (Denmark); Vedde, J [SiCon. Silicon and PV consulting, Birkeroed (Denmark)

    2011-04-15

    Large scale PV (LPV) plants, plants with a capacity of more than 200 kW, has since 2007 constituted an increasing share of the global PV installations. In 2009 large scale PV plants with cumulative power more that 1,3 GWp were connected to the grid. The necessary design data for LPV plants in Denmark are available or can be found, although irradiance data could be improved. There seems to be very few institutional barriers for LPV projects, but as so far no real LPV projects have been processed, these findings have to be regarded as preliminary. The fast growing number of very large scale solar thermal plants for district heating applications supports these findings. It has further been investigated, how to optimize the lay-out of LPV plants. Under the Danish irradiance conditions with several winter months with very low solar height PV installations on flat surfaces will have to balance the requirements of physical space - and cost, and the loss of electricity production due to shadowing effects. The potential for LPV plants in Denmark are found in three main categories: PV installations on flat roof of large commercial buildings, PV installations on other large scale infrastructure such as noise barriers and ground mounted PV installations. The technical potential for all three categories is found to be significant and in the range of 50 - 250 km2. In terms of energy harvest PV plants will under Danish conditions exhibit an overall efficiency of about 10 % in conversion of the energy content of the light compared to about 0,3 % for biomass. The theoretical ground area needed to produce the present annual electricity consumption of Denmark at 33-35 TWh is about 300 km2 The Danish grid codes and the electricity safety regulations mention very little about PV and nothing about LPV plants. It is expected that LPV plants will be treated similarly to big wind turbines. A number of LPV plant scenarios have been investigated in detail based on real commercial offers and

  5. Report from the 6th Workshop on Extremely Large Databases

    Directory of Open Access Journals (Sweden)

    Daniel Liwei Wang

    2013-05-01

    Full Text Available Petascale data management and analysis remain one of the main unresolved challenges in today's computing. The 6th Extremely Large Databases workshop was convened alongside the XLDB conference to discuss the challenges in the health care, biology, and natural resources communities. The role of cloud computing, the dominance of file-based solutions in science applications, in-situ and predictive analysis, and commercial software use in academic environments were discussed in depth as well. This paper summarizes the discussions of this workshop.

  6. Advanced radiation detector development mercuric iodide, silicon with internal gain, hybrid scintillator/semiconductor detectors. Comprehensive summary report, 1976-1985

    International Nuclear Information System (INIS)

    Huth, G.C.; Dabrowski, A.J.

    1985-01-01

    Accomplishments are reported in the development of a compound semi-insulator mercuric iodide (HgI 2 ) for nuclear radiation detection and spectroscopy, early lung cancer detection and localization in the uranium miner/worker population, computer digital image processing and image reconstruction research, and a concept for multiple, filtered x-ray computed tomography scanning to reveal chemical compositional information. Another area of interest is the study of new advances in the area of silicon detectors with internal gain (''avalanche'')

  7. Large Peripheral Osteoma of the Mandible: A Case Report

    Directory of Open Access Journals (Sweden)

    Emel Bulut

    2010-01-01

    Full Text Available Osteomas are benign, slow-growing osteogenic tumors commonly occurring in the craniofacial bones. Osteomas are characterized by the proliferation of compact and/or cancellous bone. It can be of a central, peripheral, or extraskeletal type. The peripheral type arises from the periosteum and is rarely seen in the mandible. The lingual surface and lower border of the body are the most common locations of these lesions. They are usually asymptomatic and can be discovered in routine clinical and radiographic examination. In this paper, we presented a large solitary peripheral osteoma located in the buccal surface of the left posterior mandible and causing facial deformity in a 37-year-old woman. Radiographic examination by computed tomography revealed radiopacity with a well-circumscribed, pedunculated mass approximately 3 cm in size. The osteoma was removed surgically, and no recurrence has been observed.

  8. A superconducting large-angle magnetic suspension. Final report

    International Nuclear Information System (INIS)

    Downer, J.R.; Anastas, G.V. Jr.; Bushko, D.A.; Flynn, F.J.; Goldie, J.H.; Gondhalekar, V.; Hawkey, T.J.; Hockney, R.L.; Torti, R.P.

    1992-12-01

    SatCon Technology Corporation has completed a Small Business Innovation Research (SBIR) Phase 2 program to develop a Superconducting Large-Angle Magnetic Suspension (LAMS) for the NASA Langley Research Center. The Superconducting LAMS was a hardware demonstration of the control technology required to develop an advanced momentum exchange effector. The Phase 2 research was directed toward the demonstration for the key technology required for the advanced concept CMG, the controller. The Phase 2 hardware consists of a superconducting solenoid ('source coils') suspended within an array of nonsuperconducting coils ('control coils'), a five-degree-of-freedom positioning sensing system, switching power amplifiers, and a digital control system. The results demonstrated the feasibility of suspending the source coil. Gimballing (pointing the axis of the source coil) was demonstrated over a limited range. With further development of the rotation sensing system, enhanced angular freedom should be possible

  9. A large gastrointestinal stromal tumor of duodenum: a case report

    Directory of Open Access Journals (Sweden)

    Hadi Ahmadi Amoli

    2014-01-01

    Case presentation: The patient is a forty six years old man. He complained of frequent colic pain in left upper quadrant of abdomen for two months before admitting to the hospital. The pain resolved spontaneously after a few hours. This situation almost has been repeated every week. The patient had severe repeated melena and faint for two weeks. As soon as the patient was entered the Sina Hospital in 2012, supportive care was started. Then upper gastrointestinal endoscopy was performed for him and the bleeding point was detected. Also abdominal and pelvic computed tomography with oral and intravenous contrast was done. Finally the patient was operated on tumor diagnosis in duodenal area according to classic Whipple procedure. Conclusion: Gastrointestinal bleeding is the most common symptom of gastrointestinal stromal tumors. The bleeding is minimal and chronic. It will be progress to sudden and severe bleeding. Diagnosis is done by upper gastrointestinal endoscopy and biopsy. The large tumors with high mitotic

  10. Leptospirosis complicating with acute large bowel gangrene: a case report.

    Science.gov (United States)

    Zamri, Z; Shaker, A H; Razman, J

    2012-01-01

    Leptospirosis is a zoonosis with worldwide distribution. It is often referred to as swineherd's disease, swamp fever or mud fever. In recent years there is increase incidence in leptospirosis in human. The incidence varies from sporadic in temperate zones to endemic in the tropical countries. Leptospirosis generally present with features of bacterial infection in acute phase following with multi organs complications. Acute bowel ischaemia with perforation following leptospirosis is a rare presentation . To the best of our knowledge, this is the first case report of such condition. The surgical management of this rare incidence will be discussed.

  11. Spontaneous regression of a large hepatocellular carcinoma: case report

    Directory of Open Access Journals (Sweden)

    Alqutub, Adel

    2011-01-01

    Full Text Available The prognosis of untreated advanced hepatocellular carcinoma (HCC is grim with a median survival of less than 6 months. Spontaneous regression of HCC has been defined as the disappearance of the hepatic lesions in the absence of any specific therapy. The spontaneous regression of a very large HCC is very rare and limited data is available in the English literature. We describe spontaneous regression of hepatocellular carcinoma in a 65-year-old male who presented to our clinic with vague abdominal pain and weight loss of two months duration. He was found to have multiple hepatic lesions with elevation of serum alpha-fetoprotein (AFP level to 6,500 µg/L (normal <20 µg/L. Computed tomography revealed advanced HCC replacing almost 80% of the right hepatic lobe. Without any intervention the patient showed gradual improvement over a period of few months. Follow-up CT scan revealed disappearance of hepatic lesions with progressive decline of AFP levels to normal. Various mechanisms have been postulated to explain this rare phenomenon, but the exact mechanism remains a mystery.

  12. Archive Inventory Management System (AIMS) — A Fast, Metrics Gathering Framework for Validating and Gaining Insight from Large File-Based Data Archives

    Science.gov (United States)

    Verma, R. V.

    2018-04-01

    The Archive Inventory Management System (AIMS) is a software package for understanding the distribution, characteristics, integrity, and nuances of files and directories in large file-based data archives on a continuous basis.

  13. Second progress report on pre-test calculations for the large block test

    International Nuclear Information System (INIS)

    Lee, K.H.

    1995-01-01

    The US Department of Energy's (DOE) Yucca Mountain Site Characterization Project (YMP) is investigating the suitability of the Topopah Spring tuff in the thick vadose zone at Yucca Mountain, Nevada, as a host rock for permanent disposal of high-level radioactive waste. As part of the YMP, a group of field tests, called the Large Block Test (LBT), will be conducted on a large electrically heated block of Topopah Spring tuff. The block will be heated by electrical heaters. The goals of the LBT are to gain information on the coupled thermal-mechanical-hydrological-chemical processes that will be active in the near-field environment of a repository; to provide field data for testing and calibrating models; and to help in the development of measurement systems and techniques. In this second progress report, we present results of the final set of numerical modeling calculations performed in support of the LBT design. The results include block temperatures and heat fluxes across the surfaces. The results are applied primarily to the design of guard heaters to enforce adiabatic conditions along the block walls. Conduction-only runs are adequate to estimate the thermal behavior of the system, because earlier calculations showed that heat transfer in the block is expected to be dominated by conduction. In addition, conduction-only runs can be made at substantially shorter execution times than full hydrothermal runs. We also run a two-dimensional, hydrothermal, discrete fracture model, with 200-μm vertical fractures parallel to the heaters and occurring at a uniform spacing of 30 cm. The results show the development of distinct dryout and recondensation zones. The dryout zones are thickest at the fractures and thinnest in the matrix midway between the fractures

  14. Progress report on pre-test calculations for the large block test

    International Nuclear Information System (INIS)

    Lee, K.H.

    1995-01-01

    The U.S. Department of Energy's (DOE) Yucca Mountain Site Characterization Project (YMP) is investigating the suitability of the Topopah Spring tuff in the thick vadose zone at Yucca Mountain, Nevada, as a host rock for permanent disposal of high-level radioactive waste. As part of the YMP, a group of field tests, referred to as the Large Block Test (LBT), will be conducted on a large electrically heated block of Topopah Spring tuff, isolated at Fran Ridge, Nevada Test Site. The block, which will be 3 x 3 m in horizontal dimensions and 4.5 m in height, will be heated by electrical heaters. The goals of the LBT axe to gain information on the coupled thermal-mechanical-hydrological-chemical processes active in the near-field environment of a repository; to provide field data for testing and calibrating models; and to help the development of measurement systems and techniques. This progress report presents results of on-going numerical modeling calculations carried out in support of the LBT design. An equivalent continuum model with an upper boundary temperature of 60 degrees C was used to simulate the hydrothermal response of the block to heating over a one-year period. The total heating power was started at 1500 W and later reduced to maintain an approximately uniform temperature of 138-140 degrees C. For a homogeneous bulk permeability case, the results show the formation of a distinct dry-out zone in and around the heater plane, and well-developed condensation zones above and below the heater plane. For a heterogeneous permeability distribution, the condensation zone above the heater plane was not well developed. This difference in results suggests that water saturation changes might be sensitive to changes in bulk permeability distribution. Rock temperatures were almost unaffected by permeability distribution. Heat flow was dominated by conduction. No liquid flow through the top of the block was predicted

  15. Development of advanced solid state radiation detectors: mercuric iodide and high gain silicon avalanche structures. Annual progress report, December 1, 1984-November 30, 1985

    International Nuclear Information System (INIS)

    Huth, G.C.; Dabrowski, A.J.

    1986-04-01

    This report covers the period from December 1984 through November 1985 for this research project sponsored by the Office of Health and Environmental Research of the Dept. of Energy. This work has two primary research objectives. The first is continuing development of the material mercuric iodide (HgI 2 ) and its applications to energy dispersive x-ray analysis and gamma ray spectrometry. The second task involves investigation of silicon ''avalanche'' (internal electron gain) radiation detector structures fabricated from new neutron transmutation doped (NTD) silicon single crystal

  16. Maternal glycated haemoglobin, pre-gestational weight, pregnancy weight gain and risk of large-for-gestational-age babies: a Danish cohort study of 209 singleton Type 1 diabetic pregnancies

    DEFF Research Database (Denmark)

    Nielsen, Gunnar Lauge; Dethlefsen, Claus; Møller, Anna Margrethe

    2007-01-01

    between glycated haemoglobin (HbA1c) and relative risk of delivering an LGA baby was quantified based on logistic regression models and stratified analysis controlling for the five covariates. Results We included 209 singleton pregnancies with assessable HbA1c values of which 59% [95% confidence interval......Aims To examine the association between maternal glycated haemoglobin in the second half of diabetic pregnancies and the relative risk of delivering large-for-gestational-age (LGA) babies, controlling for maternal body mass index (BMI) before pregnancy, weight gain, age, White class and smoking...... (CI) 52-65%] terminated with an LGA baby. Increasing levels of HbA1c, BMI and weight gain were all associated with increasing risk of delivering an LGA baby. Analyses stratified according to maternal BMI showed that the association between HbA1c and risk of delivering an LGA baby was restricted...

  17. NIAC Phase I Study Final Report on Large Ultra-Lightweight Photonic Muscle Space Structures

    Science.gov (United States)

    Ritter, Joe

    2016-01-01

    The research goal is to develop new tools support NASA's mission of understanding of the Cosmos by developing cost effective solutions that yield a leap in performance and science data. 'Maikalani' in Hawaiian translates to, "knowledge we gain from the cosmos." Missions like Hubble have fundamentally changed humanity's view of the cosmos. Last year's Nobel prize in physics was a result of astronomical discoveries. $9B class JWST size (6.5 meter diameter) space telescopes, when launched are anticipated to rewrite our knowledge of physics. Here we report on a neoteric meta-material telescope mirror technology designed to enable a factor of 100 or more reduction in areal density, a factor of 100 reduction in telescope production and launch costs as well as other advantages; a leap to enable missions to image the cosmos in unprecedented detail, with the associated gain in knowledge. Whether terahertz, visible or X-ray, reflectors used for high quality electromagnetic imaging require shape accuracy (surface figure) to far better than 1 wavelength (lambda) of the incident photons, more typically lambda/10 or better. Imaging visible light therefore requires mirror surfaces that approximate a desired curve (e.g. a sphere or paraboloid) with smooth shape deviation of th less than approximately 1/1000 the diameter of a human hair. This requires either thick high modulus material like glass or metal, or actuators to control mirror shape. During Phase I our team studied a novel solution to this systems level design mass/shape tradespace requirement both to advance the innovative space technology concept and also to help NASA and other agencies meet current operational and future mission requirements. Extreme and revolutionary NASA imaging missions such as Terrestrial Planet Imager (TPI) require lightweight mirrors with minimum diameters of 20 to 40 meters. For reference, NASA's great achievement; the Hubble space telescope, is only 2.4 meters in diameter. What is required is a

  18. A gain-coefficient switched Alexandrite laser

    International Nuclear Information System (INIS)

    Lee, Chris J; Van der Slot, Peter J M; Boller, Klaus-J

    2013-01-01

    We report on a gain-coefficient switched Alexandrite laser. An electro-optic modulator is used to switch between high and low gain states by making use of the polarization dependent gain of Alexandrite. In gain-coefficient switched mode, the laser produces 85 ns pulses with a pulse energy of 240 mJ at a repetition rate of 5 Hz.

  19. Should I Gain Weight?

    Science.gov (United States)

    ... Videos for Educators Search English Español Should I Gain Weight? KidsHealth / For Teens / Should I Gain Weight? ... something about it. Why Do People Want to Gain Weight? Some of the reasons people give for ...

  20. Diagnostic pitfalls associated with a large true posterior communicating artery aneurysm: a case report.

    Science.gov (United States)

    Nagatani, Kimihiro; Otani, Naoki; Seno, Soichiro; Takeuchi, Satoru; Wada, Kojiro; Mori, Kentaro

    2013-10-01

    True posterior communicating artery (PCoA) aneurysm is an aneurysm that originates from the PCoA, and large or giant true PCoA aneurysms are rare. We report a case of a large true PCoA aneurysm successfully clipped after anterior clinoidectomy and discuss the diagnostic pitfalls associated with this rare clinical entity.

  1. 105-DR Large sodium fire facility soil sampling data evaluation report

    International Nuclear Information System (INIS)

    Adler, J.G.

    1996-01-01

    This report evaluates the soil sampling activities, soil sample analysis, and soil sample data associated with the closure activities at the 105-DR Large Sodium Fire Facility. The evaluation compares these activities to the regulatory requirements for meeting clean closure. The report concludes that there is no soil contamination from the waste treatment activities

  2. Relationships among hepatitis C virus, hepatocellular carcinoma, and diffuse large B cell lymphoma: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Byun, Hyuk Jun; Kim, Seong Hoon [Dept. of Radiology, Daegu Fatima Hospital, Daegu (Korea, Republic of)

    2015-07-15

    Hepatitis C virus (HCV) is one of the main causes of hepatocellular carcinoma (HCC). Recent studies have reported various associations between HCV and the incidence of non-Hodgkin's lymphoma. We report the radiologic findings in a rare case of simultaneous occurrence of HCC and diffuse large B cell lymphoma in a HCV carrier.

  3. Primary Diffuse Large Cell Lymphoma of the Bladder: Case Report and Literature Review

    OpenAIRE

    Mansour Ansari; Hamid Nasrollahi; Majdaddin Rajaei; Maral Mokhtari; Seyed Hasan Hamedi; Mohammad Mohammadianpanah; Shapour Omidvari; Ahmad Mosalaei; Niloofar Ahmadloo

    2017-01-01

    Most bladder tumors are epithelial in origin. Nonepithelial cancers are rarely located in the bladder. Sarcomas are the most common malignancies among nonepithelial cancers. Primary bladder lymphoma is rare and mostly low grade. Here, we have reported a case of diffuse large cell lymphoma of the bladder. The patient, a 64-year-old man, had urinary frequency for 18 months. Abdominal sonography indicated a thick bladder wall and transurethral biopsy showed diffuse large cell lymp...

  4. Preventing Weight Gain

    Science.gov (United States)

    ... Local Programs Related Topics Diabetes Nutrition Preventing Weight Gain Language: English (US) Español (Spanish) Recommend on Facebook ... cancer. Choosing an Eating Plan to Prevent Weight Gain So, how do you choose a healthful eating ...

  5. 17 CFR Appendix B to Part 420 - Sample Large Position Report

    Science.gov (United States)

    2010-04-01

    ..., and as collateral for financial derivatives and other securities transactions $ Total Memorandum 1... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Sample Large Position Report B Appendix B to Part 420 Commodity and Securities Exchanges DEPARTMENT OF THE TREASURY REGULATIONS UNDER...

  6. Large cavernous hemangioma of the adrenal gland: Laparoscopic treatment. Report of a case

    Directory of Open Access Journals (Sweden)

    A. Agrusa

    2015-01-01

    Conclusion: Laparoscopic adrenalectomy is considered the standard treatment in case of diagnosis of benign lesions. In this case report we discussed a large adrenal cavernous hemangioma treated with laparoscopic approach. Fundamental is the study of preoperative endocrine disorders and radiologic findings to exclude signs of malignancy.

  7. Flow and wakes in large wind farms: Final report for UpWind WP8

    DEFF Research Database (Denmark)

    Barthelmie, Rebecca Jane; Frandsen, Sten Tronæs; Rathmann, Ole

    This report summarises the research undertaken through the European Commission funded project UpWind Wp8:Flow. The objective of the work was to develop understanding of flow in large wind farms and to evaluate models of power losses due to wind turbine wakes focusing on complex terrain and offshore...

  8. 78 FR 54996 - Information Reporting by Applicable Large Employers on Health Insurance Coverage Offered Under...

    Science.gov (United States)

    2013-09-09

    ... Information Reporting by Applicable Large Employers on Health Insurance Coverage Offered Under Employer... credit to help individuals and families afford health insurance coverage purchased through an Affordable... or group health insurance coverage offered by an employer to the employee that is (1) a governmental...

  9. Flow and wakes in large wind farms. Final report for UpWind WP8

    Energy Technology Data Exchange (ETDEWEB)

    Barthelmie, R.J.; Frandsen, S.T.; Rathmann, O. (Risoe DTU (Denmark)); Hansen, K. (Technical Univ. of Denmark (DTU), Kgs. Lyngby (Denmark)); Politis, E.; Prospathopoulos, J. (CRES (Greece)); Schepers, J.G. (ECN, Petten (Netherlands)); Rados, K. (NTUA, Athens (Greece)); Cabezon, D. (CENER, Sarriguren (Spain)); Schlez, W.; Neubert, A.; Heath, M. (Garrad Hassan and Partners (Germany) (United Kingdom))

    2011-02-15

    This report summarises the research undertaken through the European Commission funded project UpWind Wp8:Flow. The objective of the work was to develop understanding of flow in large wind farms and to evaluate models of power losses due to wind turbine wakes focusing on complex terrain and offshore. A crosscutting activity was to improve and compare the performance of computational fluid dynamics models with wind farm models. The report contains 6 deliverable reports and guideline to wind farm wake analysis as appendices. (Author)

  10. Research into condensed matter using large-scale apparatus. Physics, chemistry, biology. Progress report 1992-1995. Summarizing reports

    International Nuclear Information System (INIS)

    1996-01-01

    Activities for research into condensed matter have been supported by the German BMBF with approx. 102 million Deutschmarks in the years 1992 through 1995. These financial means have been distributed among 314 research projects in the fields of physics, chemistry, biology, materials science, and other fields, which all rely on the intensive utilization of photon and particle beams generated in large-scale apparatus of institutions for basic research. The volume in hand first gives information of a general kind and statistical data on the distribution of financial means, for a number of priority research projects. The project reports are summarizing reports on the progress achieved in the various projects. (CB) [de

  11. Percutaneous endoscopic intra-annular subligamentous herniotomy for large central disc herniation: a technical case report.

    Science.gov (United States)

    Lee, Sang-Ho; Choi, Kyung-Chul; Baek, Oon Ki; Kim, Ho Jin; Yoo, Seung-Hwa

    2014-04-01

    Technical case report. To describe the novel technique of percutaneous endoscopic herniotomy using a unilateral intra-annular subligamentous approach for the treatment of large centrally herniated discs. Open discectomy for large central disc herniations may have poor long-term prognosis due to heavy loss of intervertebral disc tissue, segmental instability, and recurrence of pain. Six consecutive patients who presented with back and leg pain, and/or weakness due to a large central disc herniation were treated using percutaneous endoscopic herniotomy with a unilateral intra-annular subligamentous approach. The patients experienced relief of symptoms and intervertebral disc spaces were well maintained. The annular defects were noted to be in the process of healing and recovery. Percutaneous endoscopic unilateral intra-annular subligamentous herniotomy was an effective and affordable minimally invasive procedure for patients with large central disc herniations, allowing preservation of nonpathological intradiscal tissue through a concentric outer-layer annular approach.

  12. Paul Scherrer Institute Scientific and Technical Report 1999. Volume VI: Large Research Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Foroughi, Fereydoun; Bercher, Renate; Buechli, Carmen; Meyer, Rosa [eds.

    2000-07-01

    The department GFA (Grossforschungsanlagen, Large Research Facilities) has been established in October 1998. Its main duty is operation, maintenance and development of the PSI accelerators, the spallation neutron source and the beam transport systems for pions and muons. A large effort of this group concerns the planning and co-ordination of new projects like e.g. the assembly of the synchrotron light source (SLS), design studies of a new proton therapy facility, the ultracold neutron source and a new intensive secondary beam line for low energy muons. A large fraction of this report is devoted to research especially in the field of materials Science. The studies include large scale molecular dynamics computer simulations on the elastic and plastic behavior of nanostructured metals, complemented by experimental mechanical testing using micro-indentation and miniaturized tensile testing, as well as microstructural characterisation and strain field mapping of metallic coatings and thin ceramic layers, the latter done with synchrotron radiation.

  13. Paul Scherrer Institute Scientific and Technical Report 1999. Volume VI: Large Research Facilities

    International Nuclear Information System (INIS)

    Foroughi, Fereydoun; Bercher, Renate; Buechli, Carmen; Meyer, Rosa

    2000-01-01

    The department GFA (Grossforschungsanlagen, Large Research Facilities) has been established in October 1998. Its main duty is operation, maintenance and development of the PSI accelerators, the spallation neutron source and the beam transport systems for pions and muons. A large effort of this group concerns the planning and co-ordination of new projects like e.g. the assembly of the synchrotron light source (SLS), design studies of a new proton therapy facility, the ultracold neutron source and a new intensive secondary beam line for low energy muons. A large fraction of this report is devoted to research especially in the field of materials Science. The studies include large scale molecular dynamics computer simulations on the elastic and plastic behavior of nanostructured metals, complemented by experimental mechanical testing using micro-indentation and miniaturized tensile testing, as well as microstructural characterisation and strain field mapping of metallic coatings and thin ceramic layers, the latter done with synchrotron radiation

  14. Determination of the STIS CCD Gain

    Science.gov (United States)

    Riley, Allyssa; Monroe, TalaWanda; Lockwood, Sean

    2016-09-01

    This report summarizes the analysis and absolute gain results of the STIS Cycle 23 special calibration program 14424 that was designed to measure the gain of amplifiers A, C and D at nominal gain settings of 1 and 4 e-/DN. We used the mean-variance technique and the results indicate a mean-variance technique.

  15. Primary Diffuse Large Cell Lymphoma of the Bladder: Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Mansour Ansari

    2017-01-01

    Full Text Available Most bladder tumors are epithelial in origin. Nonepithelial cancers are rarely located in the bladder. Sarcomas are the most common malignancies among nonepithelial cancers. Primary bladder lymphoma is rare and mostly low grade. Here, we have reported a case of diffuse large cell lymphoma of the bladder. The patient, a 64-year-old man, had urinary frequency for 18 months. Abdominal sonography indicated a thick bladder wall and transurethral biopsy showed diffuse large cell lymphoma. Immunohistochemistry (IHC results showed that the tumor was positive for CD20, CD45, and Pax-5 and negative for BCL-2, cytokeratin, and S100. He had a normal bone marrow biopsy, abdominal, pelvic and chest CT scans. He had no B symptoms. The patient received 6 cycles of R-CHOP followed by radiotherapy (36 Gy to the pelvis. Six months after treatment, the patient is well and has returned to work. We have searched PubMed for primary diffuse large cell lymphoma. Primary diffuse large cell lymphoma of the bladder is best treated according to treatment for diffuse large cell lymphoma of other sites, which includes chemotherapy and radiotherapy. As seen in our review, primary diffuse large cell lymphoma of the bladder has a similar clinical course to diffuse large cell lymphoma of other sites.

  16. Extracting and analyzing ejection fraction values from electronic echocardiography reports in a large health maintenance organization.

    Science.gov (United States)

    Xie, Fagen; Zheng, Chengyi; Yuh-Jer Shen, Albert; Chen, Wansu

    2017-12-01

    The left ventricular ejection fraction value is an important prognostic indicator of cardiovascular outcomes including morbidity and mortality and is often used clinically to indicate severity of heart disease. However, it is usually reported in free-text echocardiography reports. We developed and validated a computerized algorithm to extract ejection fraction values from echocardiography reports and applied the algorithm to a large volume of unstructured echocardiography reports between 1995 and 2011 in a large health maintenance organization. A total of 621,856 echocardiography reports with a description of ejection fraction values or systolic functions were identified, of which 70 percent contained numeric ejection fraction values and the rest (30%) were text descriptions explicitly indicating the systolic left ventricular function. The 12.1 percent (16.0% for male and 8.4% for female) of these extracted ejection fraction values are <45 percent. Validation conducted based on a random sample of 200 reports yielded 95.0 percent sensitivity and 96.9 percent positive predictive value.

  17. Clip reconstruction of a large right MCA bifurcation aneurysm. Case report

    Directory of Open Access Journals (Sweden)

    Giovani A.

    2014-06-01

    Full Text Available We report a case of complex large middle cerebral artery (MCA bifurcation aneurysm that ruptured during dissection from the very adherent MCA branches but was successfully clipped and the MCA bifurcation reconstructed using 4 Yasargill clips. Through a right pterional craniotomy the sylvian fissure was largely opened as to allow enough workspace for clipping the aneurysm and placing a temporary clip on M1. The pacient recovered very well after surgery and was discharged after 1 week with no neurological deficit. Complex MCA bifurcation aneurysms can be safely reconstructed using regular clips, without the need of using fenestrated clips or complex by-pass procedures.

  18. Large-scale building integrated photovoltaics field trial. First technical report - installation phase

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This report summarises the results of the first eighteen months of the Large-Scale Building Integrated Photovoltaic Field Trial focussing on technical aspects. The project aims included increasing awareness and application of the technology, raising the UK capabilities in application of the technology, and assessing the potential for building integrated photovoltaics (BIPV). Details are given of technology choices; project organisation, cost, and status; and the evaluation criteria. Installations of BIPV described include University buildings, commercial centres, and a sports stadium, wildlife park, church hall, and district council building. Lessons learnt are discussed, and a further report covering monitoring aspects is planned.

  19. Large Complex Odontoma of Mandible in a Young Boy: A Rare and Unusual Case Report

    Directory of Open Access Journals (Sweden)

    G. Siva Prasad Reddy

    2014-01-01

    Full Text Available Odontomas are the most common odontogenic tumors. They are broadly classified in to Compound Odontoma and Complex Odontoma. Among them complex odontoma is a rare tumor. Occasionally this tumor becomes large, causing expansion of bone followed by facial asymmetry. Otherwise these tumors are asymptomatic and are generally diagnosed on radiographic examination. We report a rare case of complex odontoma of mandible in a young boy. The tumor was treated by surgical excision under general anesthesia.

  20. Standing Together for Reproducibility in Large-Scale Computing: Report on reproducibility@XSEDE

    OpenAIRE

    James, Doug; Wilkins-Diehr, Nancy; Stodden, Victoria; Colbry, Dirk; Rosales, Carlos; Fahey, Mark; Shi, Justin; Silva, Rafael F.; Lee, Kyo; Roskies, Ralph; Loewe, Laurence; Lindsey, Susan; Kooper, Rob; Barba, Lorena; Bailey, David

    2014-01-01

    This is the final report on reproducibility@xsede, a one-day workshop held in conjunction with XSEDE14, the annual conference of the Extreme Science and Engineering Discovery Environment (XSEDE). The workshop's discussion-oriented agenda focused on reproducibility in large-scale computational research. Two important themes capture the spirit of the workshop submissions and discussions: (1) organizational stakeholders, especially supercomputer centers, are in a unique position to promote, enab...

  1. Turbidity and plant growth in large slow-flowing lowland rivers: progress report March 1989

    OpenAIRE

    Marker, A.F.H.

    1989-01-01

    The River Great Ouse is a highly managed large lowland river in eastern England. It drains rich arable land in the Midlands and Eastern England and over the years nutrient concentrations have increased and there is a general perception that the clarity of the water has decreased. The main river channels have been dredged a number of times partly for flood control reasons but also for recreational boating and navigation activities. The period covered by this first report has been used to devel...

  2. LDRD final report : robust analysis of large-scale combinatorial applications.

    Energy Technology Data Exchange (ETDEWEB)

    Carr, Robert D.; Morrison, Todd (University of Colorado, Denver, CO); Hart, William Eugene; Benavides, Nicolas L. (Santa Clara University, Santa Clara, CA); Greenberg, Harvey J. (University of Colorado, Denver, CO); Watson, Jean-Paul; Phillips, Cynthia Ann

    2007-09-01

    Discrete models of large, complex systems like national infrastructures and complex logistics frameworks naturally incorporate many modeling uncertainties. Consequently, there is a clear need for optimization techniques that can robustly account for risks associated with modeling uncertainties. This report summarizes the progress of the Late-Start LDRD 'Robust Analysis of Largescale Combinatorial Applications'. This project developed new heuristics for solving robust optimization models, and developed new robust optimization models for describing uncertainty scenarios.

  3. Accidental intravenous infusion of a large dose of magnesium sulphate during labor: A case report

    Directory of Open Access Journals (Sweden)

    Kamal Kumar

    2013-01-01

    Full Text Available During labor and child delivery, a wide range of drugs are administered. Most of these medications are high-alert medications, which can cause significant harm to the patient due to its inadvertent use. Errors could be caused due to unfamiliarity with safe dosage ranges, confusion between similar looking drugs, mislabeling of drugs, equipment misuse, or malfunction and communication errors. We report a case of inadvertent infusion of a large dose of magnesium sulphate in a pregnant woman.

  4. Developmental gains in visuospatial memory predict gains in mathematics achievement.

    Science.gov (United States)

    Li, Yaoran; Geary, David C

    2013-01-01

    Visuospatial competencies are related to performance in mathematical domains in adulthood, but are not consistently related to mathematics achievement in children. We confirmed the latter for first graders and demonstrated that children who show above average first-to-fifth grade gains in visuospatial memory have an advantage over other children in mathematics. The study involved the assessment of the mathematics and reading achievement of 177 children in kindergarten to fifth grade, inclusive, and their working memory capacity and processing speed in first and fifth grade. Intelligence was assessed in first grade and their second to fourth grade teachers reported on their in-class attentive behavior. Developmental gains in visuospatial memory span (d = 2.4) were larger than gains in the capacity of the central executive (d = 1.6) that in turn were larger than gains in phonological memory span (d = 1.1). First to fifth grade gains in visuospatial memory and in speed of numeral processing predicted end of fifth grade mathematics achievement, as did first grade central executive scores, intelligence, and in-class attentive behavior. The results suggest there are important individual differences in the rate of growth of visuospatial memory during childhood and that these differences become increasingly important for mathematics learning.

  5. Developmental gains in visuospatial memory predict gains in mathematics achievement.

    Directory of Open Access Journals (Sweden)

    Yaoran Li

    Full Text Available Visuospatial competencies are related to performance in mathematical domains in adulthood, but are not consistently related to mathematics achievement in children. We confirmed the latter for first graders and demonstrated that children who show above average first-to-fifth grade gains in visuospatial memory have an advantage over other children in mathematics. The study involved the assessment of the mathematics and reading achievement of 177 children in kindergarten to fifth grade, inclusive, and their working memory capacity and processing speed in first and fifth grade. Intelligence was assessed in first grade and their second to fourth grade teachers reported on their in-class attentive behavior. Developmental gains in visuospatial memory span (d = 2.4 were larger than gains in the capacity of the central executive (d = 1.6 that in turn were larger than gains in phonological memory span (d = 1.1. First to fifth grade gains in visuospatial memory and in speed of numeral processing predicted end of fifth grade mathematics achievement, as did first grade central executive scores, intelligence, and in-class attentive behavior. The results suggest there are important individual differences in the rate of growth of visuospatial memory during childhood and that these differences become increasingly important for mathematics learning.

  6. Developmental Gains in Visuospatial Memory Predict Gains in Mathematics Achievement

    Science.gov (United States)

    Li, Yaoran; Geary, David C.

    2013-01-01

    Visuospatial competencies are related to performance in mathematical domains in adulthood, but are not consistently related to mathematics achievement in children. We confirmed the latter for first graders and demonstrated that children who show above average first-to-fifth grade gains in visuospatial memory have an advantage over other children in mathematics. The study involved the assessment of the mathematics and reading achievement of 177 children in kindergarten to fifth grade, inclusive, and their working memory capacity and processing speed in first and fifth grade. Intelligence was assessed in first grade and their second to fourth grade teachers reported on their in-class attentive behavior. Developmental gains in visuospatial memory span (d = 2.4) were larger than gains in the capacity of the central executive (d = 1.6) that in turn were larger than gains in phonological memory span (d = 1.1). First to fifth grade gains in visuospatial memory and in speed of numeral processing predicted end of fifth grade mathematics achievement, as did first grade central executive scores, intelligence, and in-class attentive behavior. The results suggest there are important individual differences in the rate of growth of visuospatial memory during childhood and that these differences become increasingly important for mathematics learning. PMID:23936154

  7. Large LOCA-earthquake combination probability assessment - Load combination program. Project 1 summary report

    Energy Technology Data Exchange (ETDEWEB)

    Lu, S; Streit, R D; Chou, C K

    1980-01-01

    This report summarizes work performed for the U.S. Nuclear Regulatory Commission (NRC) by the Load Combination Program at the Lawrence Livermore National Laboratory to establish a technical basis for the NRC to use in reassessing its requirement that earthquake and large loss-of-coolant accident (LOCA) loads be combined in the design of nuclear power plants. A systematic probabilistic approach is used to treat the random nature of earthquake and transient loading to estimate the probability of large LOCAs that are directly and indirectly induced by earthquakes. A large LOCA is defined in this report as a double-ended guillotine break of the primary reactor coolant loop piping (the hot leg, cold leg, and crossover) of a pressurized water reactor (PWR). Unit 1 of the Zion Nuclear Power Plant, a four-loop PWR-1, is used for this study. To estimate the probability of a large LOCA directly induced by earthquakes, only fatigue crack growth resulting from the combined effects of thermal, pressure, seismic, and other cyclic loads is considered. Fatigue crack growth is simulated with a deterministic fracture mechanics model that incorporates stochastic inputs of initial crack size distribution, material properties, stress histories, and leak detection probability. Results of the simulation indicate that the probability of a double-ended guillotine break, either with or without an earthquake, is very small (on the order of 10{sup -12}). The probability of a leak was found to be several orders of magnitude greater than that of a complete pipe rupture. A limited investigation involving engineering judgment of a double-ended guillotine break indirectly induced by an earthquake is also reported. (author)

  8. Large LOCA-earthquake combination probability assessment - Load combination program. Project 1 summary report

    International Nuclear Information System (INIS)

    Lu, S.; Streit, R.D.; Chou, C.K.

    1980-01-01

    This report summarizes work performed for the U.S. Nuclear Regulatory Commission (NRC) by the Load Combination Program at the Lawrence Livermore National Laboratory to establish a technical basis for the NRC to use in reassessing its requirement that earthquake and large loss-of-coolant accident (LOCA) loads be combined in the design of nuclear power plants. A systematic probabilistic approach is used to treat the random nature of earthquake and transient loading to estimate the probability of large LOCAs that are directly and indirectly induced by earthquakes. A large LOCA is defined in this report as a double-ended guillotine break of the primary reactor coolant loop piping (the hot leg, cold leg, and crossover) of a pressurized water reactor (PWR). Unit 1 of the Zion Nuclear Power Plant, a four-loop PWR-1, is used for this study. To estimate the probability of a large LOCA directly induced by earthquakes, only fatigue crack growth resulting from the combined effects of thermal, pressure, seismic, and other cyclic loads is considered. Fatigue crack growth is simulated with a deterministic fracture mechanics model that incorporates stochastic inputs of initial crack size distribution, material properties, stress histories, and leak detection probability. Results of the simulation indicate that the probability of a double-ended guillotine break, either with or without an earthquake, is very small (on the order of 10 -12 ). The probability of a leak was found to be several orders of magnitude greater than that of a complete pipe rupture. A limited investigation involving engineering judgment of a double-ended guillotine break indirectly induced by an earthquake is also reported. (author)

  9. Parent-Reported Patterns of Loss and Gain in Communication in 1- to 2-Year-Old Children Are Not Unique to Autism Spectrum Disorder

    Science.gov (United States)

    Brignell, Amanda; Williams, Katrina; Prior, Margot; Donath, Susan; Reilly, Sheena; Bavin, Edith L.; Eadie, Patricia; Morgan, Angela T.

    2017-01-01

    We compared loss and gain in communication from 1 to 2 years in children later diagnosed with autism spectrum disorder (n = 41), language impairment (n = 110) and in children with typical language development at 7 years (n = 831). Participants were selected from a prospective population cohort study of child language (the Early Language in…

  10. Acting to gain information

    Science.gov (United States)

    Rosenchein, Stanley J.; Burns, J. Brian; Chapman, David; Kaelbling, Leslie P.; Kahn, Philip; Nishihara, H. Keith; Turk, Matthew

    1993-01-01

    This report is concerned with agents that act to gain information. In previous work, we developed agent models combining qualitative modeling with real-time control. That work, however, focused primarily on actions that affect physical states of the environment. The current study extends that work by explicitly considering problems of active information-gathering and by exploring specialized aspects of information-gathering in computational perception, learning, and language. In our theoretical investigations, we analyzed agents into their perceptual and action components and identified these with elements of a state-machine model of control. The mathematical properties of each was developed in isolation and interactions were then studied. We considered the complexity dimension and the uncertainty dimension and related these to intelligent-agent design issues. We also explored active information gathering in visual processing. Working within the active vision paradigm, we developed a concept of 'minimal meaningful measurements' suitable for demand-driven vision. We then developed and tested an architecture for ongoing recognition and interpretation of visual information. In the area of information gathering through learning, we explored techniques for coping with combinatorial complexity. We also explored information gathering through explicit linguistic action by considering the nature of conversational rules, coordination, and situated communication behavior.

  11. Breast Implant-Associated Anaplastic Large Cell Lymphoma: Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Eva Berlin

    2018-01-01

    Full Text Available We are reporting the case of a 58-year-old woman with history of bilateral silicone breast implants for cosmetic augmentation. At 2-year interval from receiving the breast implants, she presented with swelling of the right breast with associated chest wall mass, effusion around the implant, and axillary lymphadenopathy. Pathology confirmed breast implant-associated anaplastic large cell lymphoma (stage III, T4N2M0, using BIA-ALCL TNM staging and stage IIAE, using Ann-Arbor staging. The patient underwent bilateral capsulectomy and right partial mastectomy with excision of the right breast mass and received adjuvant CHOP chemotherapy and radiation to the right breast and regional nodes. Since completion of multimodality therapy, the patient has sustained remission on both clinical exam and PET/CT scan. We report this case and review of the literature on this rare form of lymphoma.

  12. Breast Implant-Associated Anaplastic Large Cell Lymphoma: Case Report and Review of the Literature.

    Science.gov (United States)

    Berlin, Eva; Singh, Kunwar; Mills, Christopher; Shapira, Ilan; Bakst, Richard L; Chadha, Manjeet

    2018-01-01

    We are reporting the case of a 58-year-old woman with history of bilateral silicone breast implants for cosmetic augmentation. At 2-year interval from receiving the breast implants, she presented with swelling of the right breast with associated chest wall mass, effusion around the implant, and axillary lymphadenopathy. Pathology confirmed breast implant-associated anaplastic large cell lymphoma (stage III, T4N2M0, using BIA-ALCL TNM staging and stage IIAE, using Ann-Arbor staging). The patient underwent bilateral capsulectomy and right partial mastectomy with excision of the right breast mass and received adjuvant CHOP chemotherapy and radiation to the right breast and regional nodes. Since completion of multimodality therapy, the patient has sustained remission on both clinical exam and PET/CT scan. We report this case and review of the literature on this rare form of lymphoma.

  13. Patient-reported causes of heart failure in a large European sample

    DEFF Research Database (Denmark)

    Timmermans, Ivy; Denollet, Johan; Pedersen, Susanne S.

    2018-01-01

    ), psychosocial (35%, mainly (work-related) stress), and natural causes (32%, mainly heredity). There were socio-demographic, clinical and psychological group differences between the various categories, and large discrepancies between prevalence of physical risk factors according to medical records and patient...... distress (OR = 1.54, 95% CI = 0.94–2.51, p = 0.09), and behavioral causes and a less threatening view of heart failure (OR = 0.64, 95% CI = 0.40–1.01, p = 0.06). Conclusion: European patients most frequently reported comorbidities, smoking, stress, and heredity as heart failure causes, but their causal......Background: Patients diagnosed with chronic diseases develop perceptions about their disease and its causes, which may influence health behavior and emotional well-being. This is the first study to examine patient-reported causes and their correlates in patients with heart failure. Methods...

  14. Large intradural craniospinal arachnoid cyst: A case report and review of literature

    Directory of Open Access Journals (Sweden)

    Souvagya Panigrahi

    2012-01-01

    Full Text Available Presence of an arachnoid cyst at craniospinal junction is not very common. This is a very rare anatomic site, with only seven other cases reported in the literature. We report a case of large intradural craniospinal arachnoid cyst presenting with obstructive hydrocephalus and cranial nerve palsy. A 39-year-old male presented with 8-month history of neck pain, headache, vomiting, visual disturbances, diminished taste sensation, and numbness of face. He had bilateral papilledema on ophthalmoscopy. Magnetic resonance imaging (MRI revealed a posterior fossa arachnoid cyst extending down to the lower border of C5 vertebra. Posterior decompression was done through C5 laminectomy. He made a full recovery and was asymptomatic at 6-month follow-up examination. The clinical features, diagnosis, and management of these rare craniospinal arachnoid cysts are discussed.

  15. Antidepressants and Weight Gain

    Science.gov (United States)

    ... 2015;37:46. Blumenthal SR, et al. An electronic health records study of long-term weight gain following antidepressant ... your agreement to the Terms and Conditions and Privacy Policy linked below. Terms and Conditions Privacy Policy ...

  16. Weight gain - unintentional

    Science.gov (United States)

    ... diabetes Hormone changes or medical problems can also cause unintentional weight gain. This may be due to: Cushing syndrome Underactive thyroid, or low thyroid (hypothyroidism) Polycystic ovary syndrome Menopause Pregnancy Bloating, or swelling ...

  17. Reversible Hypopituitarism Associated with Intravascular Large B-Cell Lymphoma: Case Report of Successful Immunochemotherapy.

    Science.gov (United States)

    Sawada, Yusuke; Ishii, Sumiyasu; Koga, Yasuhiko; Tomizawa, Taku; Matsui, Ayako; Tomaru, Takuya; Ozawa, Atsushi; Shibusawa, Nobuyuki; Satoh, Tetsurou; Shimizu, Hiroaki; Hirato, Junko; Yamada, Masanobu

    2016-03-01

    Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma. There have been only a limited number of reports regarding pituitary dysfunction associated with IVLBCL. We present a 71-year-old woman with hypopituitarism without any hypothalamic/pituitary abnormalities as assessed by magnetic resonance imaging. She presented with edema, abducens palsy, and elevated levels of lactate dehydrogenase and soluble interleukin-2 receptor. Provocative testing showed that the peaks of luteinizing hormone, follicle-stimulating hormone, thyroid-stimulating hormone and adrenocorticotropic hormone were evoked to normal levels by simultaneous administration of luteinizing hormone-releasing hormone, thyrotropin-releasing hormone and corticotropin-releasing hormone, but the responses of these four pituitary hormones showed a delayed pattern. She was diagnosed with IVLBCL with cerebrospinal invasion by pathological findings of the bone marrow, skin, and cerebrospinal fluid. She achieved hematological remission after immunochemotherapy. Pituitary function was also restored without hormonal replacement, and the improvement of the pituitary function was confirmed by dynamic testing. We reviewed the literature with respect to hypopituitarism associated with IVLBCL. There were less than 20 case reports and most of the patients died. Endocrinological course was described in only two cases, and both of them required hormonal supplementation. To our knowledge, this is the first case of hypopituitarism induced by IVLBCL that was successfully managed by immunochemotherapy alone. This case suggests that early diagnosis and treatment of IVLBCL might improve anterior pituitary function and enable patients to avoid hormone replacement therapy.

  18. Primary testicular diffuse large B-cell lymphoma: A case report

    Directory of Open Access Journals (Sweden)

    Muhammad Sadiq

    2017-12-01

    Full Text Available Primary testicular diffuse large-B cell lymphoma (DLBCL is an uncommon and aggressive disease with predominant manifestation in the older age. Herein, we report a case of 47-year-old male patient who presented with three months history of left testis swelling. The patient underwent unilateral (left radical orchiectomy. Histopathological examination revealed extensive involvement and replacement of testicular parenchyma by a tumor composed of large discohesive sheets of cells with pleomorphic, hyperchromatic nuclei and prominent nucleoli. Immunohistochemical (IHC staining showed reactivity for LCA & Pan B (CD20 and negativity for OCT 3/4, SALL4 and Inhibin. Moreover, Pan T (CD3 highlighted reactive T-cells. These features rendered the diagnosis of DLBCL of testis. The hybrid 2-[fluorine-18] fluoro-2-deoxy-d-glucose (FDG positron emission tomography/computed tomography (PET/CT demonstrated two para-aortic FDG avid lymph nodes on the left side at the level of L2 vertebra. Presently, the patient has been planned for doxorubicin-based chemotherapy (i.e., cyclophosphamide, doxorubicin, vincristine and prednisone; CHOP along with intrathecal Methroxate (MTX, which would presumably improve the prognosis. Our study would expand the pool of this uncommon tumor towards its better understanding. Keywords: Primary testicular lymphoma, Diffuse large-B cell lymphoma, Orchiectomy, Doxorubicin-based chemotherapy

  19. Impact of gestational weight gain and prepregnancy body mass index on the prevalence of large-for-gestational age infants in two cohorts of women with type 1 insulin-dependent diabetes: a cross-sectional population study

    Science.gov (United States)

    Bowers, Katherine; Dolan, Lawrence M; Deka, Ranjan; Jackson, Chandra L; Khoury, Jane C

    2018-01-01

    Objectives Despite improvements in treatment modalities, large-for-gestational age (LGA) prevalence has remained between 30% and 40% among infants of mothers with type 1 insulin-dependent diabetes mellitus (TIDM). Our objective was to estimate LGA prevalence and examine the association between gestational weight gain (GWG) and prepregnancy body mass index (BMI) with LGA among mothers with TIDM. Design Cross-sectional study. Setting Regional data in Cincinnati, Ohio, from the Diabetes in Pregnancy Program Project (PPG), a prospective cohort for the period 1978–1993; national data from Consortium on Safe Labor (CSL), a multicentre cross-sectional study for the period 2002–2008. Participants The study included 333 pregnancies in the PPG and 358 pregnancies in the CSL. Pregnancies delivered prior to 23 weeks’ gestation were excluded. Women with TIDM in the PPG were identified according to physician confirmation of ketoacidosis, and/or c-peptide levels, and by International Classification of Diseases, ninth version codes within the CSL. LGA was identified as birth weight >90th percentile according to gestational age, race and sex. Main outcome measures LGA at birth. Results Mean±SD maternal age at delivery was 26.4±5.1 years for PPG women and 27.5±6.0 years for CSL women, p=0.008. LGA prevalence did not significantly differ between cohorts (PPG: 40.2% vs CSL: 36.6%, p=0.32). More women began pregnancy as overweight in the later cohort (PPG (16.8%) vs CSL (27.1%), pIOM) guidelines was higher in the later CSL (56.2%) vs PPG (42.3%) cohort, pIOM guidelines had a lower LGA prevalence in CSL (PPG: 30.6% vs CSL: 13.7%), p=0.001. Conclusions Normal-weight women with GWG within IOM guidelines experienced a lower LGA prevalence, supporting the importance of adherence to IOM guidelines for GWG to reduce LGA. High BMI and GWG may be hindering a reduction in LGA prevalence. PMID:29602844

  20. Maps on large-scale air quality concentrations in the Netherlands. Report on 2008

    International Nuclear Information System (INIS)

    Velders, G.J.M.; Aben, J.M.M.; Blom, W.F.; Van Dam, J.D.; Elzenga, H.E.; Geilenkirchen, G.P.; Hammingh, P.; Hoen, A.; Jimmink, B.A.; Koelemeijer, R.B.A.; Matthijsen, J.; Peek, C.J.; Schilderman, C.B.W.; Van der Sluis, O.C.; De Vries, W.J.

    2008-01-01

    Decrease expected in the number of locations exceeding the air quality limit values In the Netherlands, the number of locations were the European limit values for particulate matter and nitrogen dioxide will be exceeded is expected to decrease by 70-90%, in the period up to 2011, respectively 2015. The limit value for particulate matter from 2011 onwards, and for nitrogen dioxide from 2015 onwards, is expected to be exceeded at a small number of locations in the Netherlands, based on standing and proposed Dutch and European policies. These locations are situated mainly in the Randstad, Netherlands, in the vicinity of motorway around the large cities and in the busiest streets in large cities. Whether the limit values will actually be exceeded depends also on local policies and meteorological fluctuations. This estimate is based on large-scale concentration maps (called GCN maps) of air quality components and on additional local contributions. The concentration maps provide the best possible estimate of large-scale air quality. The degree of uncertainty about the local concentrations of particulate matter and nitrogen dioxide is estimated to be approximately 20%. This report presents the methods used to produce the GCN maps and the included emissions. It also shows the differences with respect to the maps of 2007. These maps are used by local, provincial and other authorities. MNP emphasises to keep the uncertainties in the concentrations in mind when using these maps for planning, or when comparing concentrations with limit values. This also applies to the selecting of local measures to improve the air quality. The concentration maps are available online, at http://www.mnp.nl/gcn.html [nl

  1. Maps on large-scale air quality concentrations in the Netherlands. Report on 2010

    International Nuclear Information System (INIS)

    Velders, G.J.M.; Aben, J.M.M.; Diederen, H.S.M.A.; Drissen, E; Geilenkirchen, G.P.; Jimmink, B.A.; Koekoek, A.F.; Koelemeijer, R.B.A.; Matthijsen, J.; Peek, C.J.; Van Rijn, F.J.A.; De Vries, W.J.

    2010-06-01

    In the Netherlands, the number of locations for which the European limit values for nitrogen dioxide concentrations could be exceeded is larger than was estimated last year. The limit value, from 2015 onwards, might be exceeded along 100 to 150 kilometres of city roads and along about 100 kilometres of motorways, based on standing and proposed national and European policies, not taking local policies into account. The exceedances occur mainly in the Randstad area, along motorways around the large cities, and in streets within these cities. The number of locations is about twice as large as was estimated last year, as a result of new measurements of emissions from heavy-duty vehicles, and meeting the limit value in time may require additional national and local policies. The new estimates were based on large-scale concentration maps (called GCN maps) of air quality components, and on additional local contributions. The concentration maps provided the best possible estimate of large-scale air quality. The degree of uncertainty in local concentrations of particulate matter and nitrogen dioxide was estimated at approximately 15 to 20 per cent. This report presents the methods and emissions used for producing the GCN maps. It also shows the differences with the maps produced in 2009. These maps are used by local, provincial and other authorities to define additional local measures. The PBL would like to emphasise that uncertainties in the concentrations must be kept in mind when using these maps for planning, or when comparing concentrations with limit values. This also applies to the selecting of local measures to improve the air quality. The concentration maps are available online, at http://www.pbl.nl/gcn. Keywords: GCN; particulate matter; PM10; nitrogen dioxide; limit value. [nl

  2. Hypercholesterolemia Induced by a PCSK9 Gain-of-Function Mutation Augments Angiotensin II-Induced Abdominal Aortic Aneurysms in C57BL/6 Mice-Brief Report.

    Science.gov (United States)

    Lu, Hong; Howatt, Deborah A; Balakrishnan, Anju; Graham, Mark J; Mullick, Adam E; Daugherty, Alan

    2016-09-01

    Gain-of-function mutations of PCSK9 (proprotein convertase subtilisin/kexin type 9) lead to hypercholesterolemia. This study was to determine whether infection of normocholesterolemic mice with an adeno-associated viral (AAV) vector expressing a gain-of-function mutation of mouse PCSK9 increased angiotensin II (AngII)-induced abdominal aortic aneurysms. In an initial study, male C57BL/6 mice were injected intraperitoneally with either an empty vector or PCSK9 gain-of-function mutation (D377Y). AAV at 3 doses and fed a saturated fat-enriched diet for 6 weeks. Two weeks after AAV injection, mice were infused with AngII for 4 weeks. Plasma PCSK9 concentrations were increased dose dependently in mice injected with AAV containing PCSK9D377Y mutation and positively associated with elevations of plasma cholesterol concentrations. Infection with intermediate and high doses of PCSK9D377Y.AAV led to equivalent increases of maximal width of abdominal aortas in C57BL/6 mice infused with AngII. Therefore, the intermediate dose was used in subsequent experiments. We then determined effects of PCSK9D377Y.AAV infection on 5 normolipidemic mouse strains, demonstrating that C57BL/6 mice were the most susceptible to this AAV infection. PCSK9D377Y.AAV infected male C57BL/6 mice were also compared with age-matched male low-density lipoprotein receptor(-/-) mice. Although plasma cholesterol concentrations were lower in mice infected with PCSK9D377Y.AAV, these mice had equivalent abdominal aortic aneurysmal formation, compared to low-density lipoprotein receptor(-/-) mice. In a separate study, reduced plasma PCSK9 concentrations by PCSK9 antisense oligonucleotides in male low-density lipoprotein receptor(-/-) mice did not influence AngII-induced abdominal aortic aneurysms. AAV-mediated infection with a mouse PCSK9 gain-of-function mutation is a rapid, easy, and efficient approach for inducing hypercholesterolemia and promoting abdominal aortic aneurysms in C57BL/6 mice infused with Ang

  3. The first case report of a large deletion of the BRCA1 gene in Croatia: A case report.

    Science.gov (United States)

    Musani, Vesna; Sušac, Ilona; Ozretić, Petar; Eljuga, Domagoj; Levanat, Sonja

    2017-12-01

    Breast cancer is one of the most common cancers in women, and it is the leading cause of cancer related deaths in Croatia. BRCA1 and BRCA2 gene mutations are the most common cause of hereditary breast cancer. In this report we describe a Croatian patient with no apparent family history of cancer, who developed breast cancer first at 29, and again at 33. Due to the early development of first breast cancer and triple negative status of the second, the attending physician suspected a hereditary aspect. Patient was sent to BRCA1 genetic testing. Subsequently, her mother and sister were sent to check for the mutation found in the patient. BRCA1 exons 4-6 deletion was determined and sequencing confirmed the deletion as NG_005905.2:g.107648_117905del10257. Mother and sister were not affected, but since there were no available family members on the fathers' side, it was not possible to determine if this was a case of de novo mutation. Until now, only in three reports with the similar mutation the exact mutation borders were determined. The mutation in this case was not the same as previously reported and was more than twice in size. All large deletions should be described at the nucleotide level, so that in cases with missing family data it would be possible to deduce if the mutation is already known. If the mutation is already known, it is probably not a de novo event, since it is unlikely that the breakpoints would be exactly the same more than once.

  4. A Large Rice Body-Containing Cyst Mimicking Infection following Total Hip Arthroplasty: A Case Report

    Directory of Open Access Journals (Sweden)

    Wael Bayoud

    2017-01-01

    Full Text Available Introduction. Soft tissue mass following total hip arthroplasty raises several differential diagnoses not limited to infection, hematoma, wear debris, malignancy, and bursitis. Rice body formation in the hip region is an uncommon process denoting a chronic inflammation. We report here the second case of its kind in the medical literature of a wide symptomatic rice-like body cyst complicating a total hip arthroplasty. Case Presentation. This is the case of an 82-year-old white female, presenting with a warm, red, and inflated groin five years after revision of right total hip arthroplasty. Surgical intervention reveals a large well circumscribed cyst containing well-organized rice-like bodies. This eventuality was never reported in differential diagnosis of hip periprosthetic soft tissue masses before. Conclusion. This case report helps widening the array of the differential diagnosis in patients presenting with a slow growing soft tissue mass following total hip arthroplasty, making rice-like bodies cyst a valid one to consider.

  5. A large-scale dataset of solar event reports from automated feature recognition modules

    Science.gov (United States)

    Schuh, Michael A.; Angryk, Rafal A.; Martens, Petrus C.

    2016-05-01

    The massive repository of images of the Sun captured by the Solar Dynamics Observatory (SDO) mission has ushered in the era of Big Data for Solar Physics. In this work, we investigate the entire public collection of events reported to the Heliophysics Event Knowledgebase (HEK) from automated solar feature recognition modules operated by the SDO Feature Finding Team (FFT). With the SDO mission recently surpassing five years of operations, and over 280,000 event reports for seven types of solar phenomena, we present the broadest and most comprehensive large-scale dataset of the SDO FFT modules to date. We also present numerous statistics on these modules, providing valuable contextual information for better understanding and validating of the individual event reports and the entire dataset as a whole. After extensive data cleaning through exploratory data analysis, we highlight several opportunities for knowledge discovery from data (KDD). Through these important prerequisite analyses presented here, the results of KDD from Solar Big Data will be overall more reliable and better understood. As the SDO mission remains operational over the coming years, these datasets will continue to grow in size and value. Future versions of this dataset will be analyzed in the general framework established in this work and maintained publicly online for easy access by the community.

  6. Receiver gain function: the actual NMR receiver gain

    OpenAIRE

    Mo, Huaping; Harwood, John S.; Raftery, Daniel

    2010-01-01

    The observed NMR signal size depends on the receiver gain parameter. We propose a receiver gain function to characterize how much the raw FID is amplified by the receiver as a function of the receiver gain setting. Although the receiver is linear for a fixed gain setting, the actual gain of the receiver may differ from what the gain setting suggests. Nevertheless, for a given receiver, we demonstrate that the receiver gain function can be calibrated. Such a calibration enables accurate compar...

  7. Large proportions of overweight and obese children, as well as their parents, underestimate children's weight status across Europe. The ENERGY (EuropeaN Energy balance Research to prevent excessive weight Gain among Youth) project.

    Science.gov (United States)

    Manios, Yannis; Moschonis, George; Karatzi, Kalliopi; Androutsos, Odysseas; Chinapaw, Mai; Moreno, Luis A; Bere, Elling; Molnar, Denes; Jan, Natasha; Dössegger, Alain; De Bourdeaudhuij, Ilse; Singh, Amika; Brug, Johannes

    2015-08-01

    To investigate the magnitude and country-specific differences in underestimation of children's weight status by children and their parents in Europe and to further explore its associations with family characteristics and sociodemographic factors. Children's weight and height were objectively measured. Parental anthropometric and sociodemographic data were self-reported. Children and their parents were asked to comment on children's weight status based on five-point Likert-type scales, ranging from 'I am much too thin' to 'I am much too fat' (children) and 'My child's weight is way too little' to 'My child's weight is way too much' (parents). These data were combined with children's actual weight status, in order to assess underestimation of children's weight status by children themselves and by their parents, respectively. Chi-square tests and multilevel logistic regression analyses were conducted to examine the aims of the current study. Eight European countries participating in the ENERGY (EuropeaN Energy balance Research to prevent excessive weight Gain among Youth) project. A school-based survey among 6113 children aged 10-12 years and their parents. In the total sample, 42·9 % of overweight/obese children and 27·6 % of parents of overweight/obese children underestimated their and their children's weight status, respectively. A higher likelihood for this underestimation of weight status by children and their parents was observed in Eastern and Southern compared with Central/Northern countries. Overweight or obese parents (OR=1·81; 95 % CI 1·39, 2·35 and OR=1·78, 95 % CI 1·22, 2·60), parents of boys (OR=1·32; 95 % CI 1·05, 1·67) and children from overweight/obese (OR=1·60; 95 % CI 1·29, 1·98 and OR=1·76; 95 % CI 1·29, 2·41) or unemployed parents (OR=1·53; 95 % CI 1·22, 1·92) were more likely to underestimate children's weight status. Children of overweight or obese parents, those from Eastern and Southern Europe, boys, younger children and

  8. MRI findings of a large pedunculated eccrine poroma: A case report

    International Nuclear Information System (INIS)

    Kim, Seung Hyun; Ryu, Jeong Ah; Lee, Jung Il; Pyo, Ju Yeon; Oh, Young Ha; Lee, Chul Min

    2016-01-01

    Eccrine poroma is a rare benign neoplasm of the eccrine sweat gland that usually presents as a small skin lesion such as a papule or nodule. This benign tumor has an overall good prognosis; however, eccrine porocarcinomas can arise from long-standing pre-existing benign eccrine poromas. We reported the case of a 37-year-old man with mental retardation who presented with an 8-cm pedunculated and densely pigmented eccrine poroma on the left hip. The tumor showed low signal intensity on T1-weighted MRI, with inhomogenously high signal intensity on T2-weighted images and strong contrast enhancement after intravenous gadolinium administration. It directly extended from the dermal layer, and the subcutaneous tissue was preserved. Radiologists should be aware that eccrine poromas could be large and pedunculated. Furthermore, related MRI findings and diagnostic clues should be carefully considered

  9. MRI findings of a large pedunculated eccrine poroma: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seung Hyun; Ryu, Jeong Ah; Lee, Jung Il; Pyo, Ju Yeon; Oh, Young Ha [Dept. of ,Hanyang University Guri Hospital, Guri (Korea, Republic of); Lee, Chul Min [Dept. of Radiology, Hanyang University Hospital, Seoul (Korea, Republic of)

    2016-02-15

    Eccrine poroma is a rare benign neoplasm of the eccrine sweat gland that usually presents as a small skin lesion such as a papule or nodule. This benign tumor has an overall good prognosis; however, eccrine porocarcinomas can arise from long-standing pre-existing benign eccrine poromas. We reported the case of a 37-year-old man with mental retardation who presented with an 8-cm pedunculated and densely pigmented eccrine poroma on the left hip. The tumor showed low signal intensity on T1-weighted MRI, with inhomogenously high signal intensity on T2-weighted images and strong contrast enhancement after intravenous gadolinium administration. It directly extended from the dermal layer, and the subcutaneous tissue was preserved. Radiologists should be aware that eccrine poromas could be large and pedunculated. Furthermore, related MRI findings and diagnostic clues should be carefully considered.

  10. Placement of endosseous implant in infected alveolar socket with large fenestration defect: A comparative case report

    Directory of Open Access Journals (Sweden)

    Balaji Anitha

    2010-01-01

    Full Text Available Placement of endosseous implants into infected bone is often deferred or avoided due to fear of failure. However, with the development of guided bone regeneration [GBR], some implantologists have reported successful implant placement in infected sockets, even those with fenestration defects. We had the opportunity to compare the osseointegration of an immediate implant placed in an infected site associated with a large buccal fenestration created by the removal of a root stump with that of a delayed implant placed 5 years after extraction. Both implants were placed in the same patient, in the same dental quadrant by the same implantologist. GBR was used with the fenestration defect being filled with demineralized bone graftFNx01 and covered with collagen membraneFNx08. Both implants were osseointegrated and functional when followed up after 12 months.

  11. Safety and protection for large scale superconducting magnets. FY 1984 report

    International Nuclear Information System (INIS)

    Thome, R.J.; Pillsbury, R.D. Jr.; Minervini, J.V.

    1984-11-01

    The Fusion Program is moving rapidly into design and construction of systems using magnets with stored energies in the range of hundreds of megajoules to gigajoules. For example, the toroidal field coil system alone for TFCX would store about 4 GJ and the mirror system MFTF-B would store about 1.6 GJ. Safety and protection analyses of the magnet subsystems become progressively more important as the size and complexity of the installations increase. MIT has been carrying out a program for INEL oriented toward safety and protection in large scale superconducting magnet systems. The program involves collection and analysis of information on actual magnet failures, analyses of general problems associated with safety and protection, and performance of safety oriented experiments. This report summarizes work performed in FY 1984

  12. Two-Stage Surgery for a Large Cervical Dumbbell Tumour in Neurofibromatosis 1: A Case Report

    Directory of Open Access Journals (Sweden)

    Mohd Ariff S

    2011-11-01

    Full Text Available Spinal neurofibromas occur sporadically and typically occur in association with neurofibromatosis 1. Patients afflicted with neurofibromatosis 1 usually present with involvement of several nerve roots. This report describes the case of a 14- year-old child with a large intraspinal, but extradural tumour with paraspinal extension, dumbbell neurofibroma of the cervical region extending from the C2 to C4 vertebrae. The lesions were readily detected by MR imaging and were successfully resected in a two-stage surgery. The time interval between the first and second surgery was one month. We provide a brief review of the literature regarding various surgical approaches, emphasising the utility of anterior and posterior approaches.

  13. Final report LDRD project 105816 : model reduction of large dynamic systems with localized nonlinearities.

    Energy Technology Data Exchange (ETDEWEB)

    Lehoucq, Richard B.; Segalman, Daniel Joseph; Hetmaniuk, Ulrich L. (University of Washington, Seattle, WA); Dohrmann, Clark R.

    2009-10-01

    Advanced computing hardware and software written to exploit massively parallel architectures greatly facilitate the computation of extremely large problems. On the other hand, these tools, though enabling higher fidelity models, have often resulted in much longer run-times and turn-around-times in providing answers to engineering problems. The impediments include smaller elements and consequently smaller time steps, much larger systems of equations to solve, and the inclusion of nonlinearities that had been ignored in days when lower fidelity models were the norm. The research effort reported focuses on the accelerating the analysis process for structural dynamics though combinations of model reduction and mitigation of some factors that lead to over-meshing.

  14. Receiver Gain Modulation Circuit

    Science.gov (United States)

    Jones, Hollis; Racette, Paul; Walker, David; Gu, Dazhen

    2011-01-01

    A receiver gain modulation circuit (RGMC) was developed that modulates the power gain of the output of a radiometer receiver with a test signal. As the radiometer receiver switches between calibration noise references, the test signal is mixed with the calibrated noise and thus produces an ensemble set of measurements from which ensemble statistical analysis can be used to extract statistical information about the test signal. The RGMC is an enabling technology of the ensemble detector. As a key component for achieving ensemble detection and analysis, the RGMC has broad aeronautical and space applications. The RGMC can be used to test and develop new calibration algorithms, for example, to detect gain anomalies, and/or correct for slow drifts that affect climate-quality measurements over an accelerated time scale. A generalized approach to analyzing radiometer system designs yields a mathematical treatment of noise reference measurements in calibration algorithms. By treating the measurements from the different noise references as ensemble samples of the receiver state, i.e. receiver gain, a quantitative description of the non-stationary properties of the underlying receiver fluctuations can be derived. Excellent agreement has been obtained between model calculations and radiometric measurements. The mathematical formulation is equivalent to modulating the gain of a stable receiver with an externally generated signal and is the basis for ensemble detection and analysis (EDA). The concept of generating ensemble data sets using an ensemble detector is similar to the ensemble data sets generated as part of ensemble empirical mode decomposition (EEMD) with exception of a key distinguishing factor. EEMD adds noise to the signal under study whereas EDA mixes the signal with calibrated noise. It is mixing with calibrated noise that permits the measurement of temporal-functional variability of uncertainty in the underlying process. The RGMC permits the evaluation of EDA by

  15. Large-Grain Superconducting Gun Cavity Testing Program Phase One Closing Report

    Energy Technology Data Exchange (ETDEWEB)

    Hammons, L. [Brookhaven National Lab. (BNL), Upton, NY (United States); Bellavia, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Belomestnykh, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ben-Zvi, I. [Brookhaven National Lab. (BNL), Upton, NY (United States); Cullen, C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Dai, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Degen, C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Hahn, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Masi, L. [Brookhaven National Lab. (BNL), Upton, NY (United States); McIntyre, G. [Brookhaven National Lab. (BNL), Upton, NY (United States); Schultheiss, C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Seda, T. [Brookhaven National Lab. (BNL), Upton, NY (United States); Kellerman, R. [Brookhaven National Lab. (BNL), Upton, NY (United States); Tallerico, T. [Brookhaven National Lab. (BNL), Upton, NY (United States); Todd, R. [Brookhaven National Lab. (BNL), Upton, NY (United States); Tuozzolo, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Xu, W. [Brookhaven National Lab. (BNL), Upton, NY (United States); Than, Y. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2013-10-31

    This report details the experimental configuration and RF testing results for the first phase of a large-grained niobium electron gun cavity testing program being conducted in the Small Vertical Testing Facility in the Collider-Accelerator Department. This testing is meant to explore multi-pacting in the cavity and shed light on the behavior of a counterpart cavity of identical geometry installed in the Energy Recovery LINAC being constructed in the Collider-Accelerator Department at Brookhaven National Laboratory. This test found that the Q of the large-grained cavity at 4 K reached ~6.5 × 108 and at 2 K reached a value of ~6 × 109. Both of these values are about a factor of 10 lower than would be expected for this type of cavity given the calculated surface resistance and the estimated geometry factor for this half-cell cavity. In addition, the cavity reached a peak voltage of 0.6 MV before there was sig-nificant decline in the Q value and a substantial increase in field emission. This relatively low volt-age, coupled with the low Q and considerable field emission suggest contamination of the cavity interior, possibly during experimental assembly. The results may also suggest that additional chemical etching of the interior surface of the cavity may be beneficial. Throughout the course of testing, various challenges arose including slow helium transfer to the cryostat and cable difficulties. These difficulties and others were eventually resolved, and the re-port discusses the operating experience of the experiment thus far and the plans for future work aimed at exploring the nature of multipacting with a copper cathode inserted into the cavity.

  16. Intravascular large B-cell lymphoma of the kidney: A case report

    Directory of Open Access Journals (Sweden)

    Jia Nan

    2011-09-01

    Full Text Available Abstract We report a 41-year-old Chinese woman with intravascular large B-cell lymphoma diagnosed by percutaneous renal biopsy. The patient was admitted to Nanfang Hospital of Southern Medical University, Guangzhou, China with complaints of high spiking fever for a month and bilateral lower limb fatigue with difficulty ambulating for the past 5 months. She had renal dysfunction with a total urinary protein of 5.61 g/dL (56.1 g/L, serum albumin of 2.89 g/dL (28.9 g/L, urea nitrogen of 2.24 mg/dL (1.6 mmol/L, and serum creatinine of 0.54 mg/dL (48 μmol/L. Bone marrow biopsy revealed myeloproliferative disorder without abnormal myeloid or lymphocytic proliferation. Positron Emission Tomography-Computed Tomography (PET-CT showed marked bilateral swelling and enlargement of the renal parenchyma with splenic enlargement and involvement of multiple vertebrae. Percutaneous renal biopsy showed island-like accumulations of medium to large lymphoid cells in many areas of the interstitium, with round vesicular nuclei containing distinct basophilic nucleoli. Immunohistochemical analysis together with other supportive investigation confirmed the diagnosis of intravascular large B-cell lymphoma. Ten days later, she was started on chemotherapy with CHOP (cyclophosphamide, doxorubicin, leurocristime and prednisone for a week. Palliative radiotherapy DT 40Gy/20F with other supportive treatment was provided for metastatic foci in the medullary cavity of the sternum, T1-T7. The patient regained muscle strength in both lower limbs and was able to walk again after three weeks. The patient was discharged after hepatic and renal function and proteinuria values had returned to normal. Follow-up data shows the patient to be alive nine months after discharge.

  17. Maps on large-scale air quality concentrations in the Netherlands. Report on 2009

    International Nuclear Information System (INIS)

    Velders, G.J.M.; Aben, J.M.M.; Blom, W.F.; Diederen, H.S.M.A.; Geilenkirchen, G.P.; Jimmink, B.A.; Koekoek, A.F.; Koelemeijer, R.B.A.; Matthijsen, J.; Peek, C.J.; Van Rijn, F.J.A.; Van Schijndel, M.W.; Van der Sluis, O.C.; De Vries, W.J.

    2009-06-01

    In the Netherlands, the number of locations where the European limit values for particulate matter and nitrogen dioxide concentrations could be exceeded is lower than was estimated last year. The limit value for particulate matter, from 2011 onwards, is possibly be exceeded at only a few locations in the Netherlands, based on standing and proposed national and European policies. These locations are situated mainly in the Randstad area in the Netherlands, in the vicinity of motorways around the large cities, and close to stables in agricultural areas. The limit value for nitrogen dioxide, from 2015 onwards, is possibly to be exceeded along 100 kilometres of roads in cities and along 50 kilometres of motorways. Whether the limit values will actually be exceeded depends also on local policies and meteorological fluctuations. This estimate was based on large-scale concentration maps (called GCN maps) of air quality components, and on additional local contributions. The concentration maps provided the best possible estimate of large-scale air quality. The degree of uncertainty in local concentrations of particulate matter and nitrogen dioxide was estimated to be approximately 15 to 20%. This report presents the methods and emissions used for producing the GCN maps. It also shows the differences with respect to the maps of 2008. These maps are used by local, provincial and other authorities to define additional local measures. PBL would like to emphasise that uncertainties in the concentrations must be kept in mind when using these maps for planning, or when comparing concentrations with limit values. This also applies to the selecting of local measures to improve the air quality. The concentration maps are available online, at http://www. pbl.nl/gcn [nl

  18. Paul Scherrer Institute Scientific and Technical Report 2000. Volume VI: Large Research Facilities

    International Nuclear Information System (INIS)

    Foroughi, Fereydoun; Bercher, Renate; Buechli, Carmen; Zumkeller, Lotty

    2001-01-01

    The PSI Department Large Research Facilities (GFA) joins the efforts to provide an excellent research environment to Swiss and foreign research groups on the experimental facilities driven by our high intensity proton accelerator complex. Its divisions care for the running, maintenance and enhancement of the accelerator complex, the primary proton beamlines, the targets and the secondary beams as well as the neutron spallation source SINQ. The division for technical support and coordination provides for technical support to the research facility complementary to the basic logistic available from the department for logistics and marketing. Besides running the facilities, the staff of the department is also involved in theoretical and experimental research projects. Some of them address basic scientific questions mainly concerning the properties of micro- or nanostructured materials: experiments as well as large scale computer simulations of molecular dynamics were performed to investigate nonclassical materials properties. Others are related to improvements or extensions of the capabilities of our facilities. We also report on intriguing results from applications of the neutron capture radiography, the prompt gamma activation method and the isotope production facility at SINQ

  19. ParaText : scalable solutions for processing and searching very large document collections : final LDRD report.

    Energy Technology Data Exchange (ETDEWEB)

    Crossno, Patricia Joyce; Dunlavy, Daniel M.; Stanton, Eric T.; Shead, Timothy M.

    2010-09-01

    This report is a summary of the accomplishments of the 'Scalable Solutions for Processing and Searching Very Large Document Collections' LDRD, which ran from FY08 through FY10. Our goal was to investigate scalable text analysis; specifically, methods for information retrieval and visualization that could scale to extremely large document collections. Towards that end, we designed, implemented, and demonstrated a scalable framework for text analysis - ParaText - as a major project deliverable. Further, we demonstrated the benefits of using visual analysis in text analysis algorithm development, improved performance of heterogeneous ensemble models in data classification problems, and the advantages of information theoretic methods in user analysis and interpretation in cross language information retrieval. The project involved 5 members of the technical staff and 3 summer interns (including one who worked two summers). It resulted in a total of 14 publications, 3 new software libraries (2 open source and 1 internal to Sandia), several new end-user software applications, and over 20 presentations. Several follow-on projects have already begun or will start in FY11, with additional projects currently in proposal.

  20. Model checking methodology for large systems, faults and asynchronous behaviour. SARANA 2011 work report

    International Nuclear Information System (INIS)

    Lahtinen, J.; Launiainen, T.; Heljanko, K.; Ropponen, J.

    2012-01-01

    Digital instrumentation and control (I and C) systems are challenging to verify. They enable complicated control functions, and the state spaces of the models easily become too large for comprehensive verification through traditional methods. Model checking is a formal method that can be used for system verification. A number of efficient model checking systems are available that provide analysis tools to determine automatically whether a given state machine model satisfies the desired safety properties. This report reviews the work performed in the Safety Evaluation and Reliability Analysis of Nuclear Automation (SARANA) project in 2011 regarding model checking. We have developed new, more exact modelling methods that are able to capture the behaviour of a system more realistically. In particular, we have developed more detailed fault models depicting the hardware configuration of a system, and methodology to model function-block-based systems asynchronously. In order to improve the usability of our model checking methods, we have developed an algorithm for model checking large modular systems. The algorithm can be used to verify properties of a model that could otherwise not be verified in a straightforward manner. (orig.)

  1. Paul Scherrer Institute Scientific and Technical Report 2000. Volume VI: Large Research Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Foroughi, Fereydoun; Bercher, Renate; Buechli, Carmen; Zumkeller, Lotty [eds.

    2001-07-01

    The PSI Department Large Research Facilities (GFA) joins the efforts to provide an excellent research environment to Swiss and foreign research groups on the experimental facilities driven by our high intensity proton accelerator complex. Its divisions care for the running, maintenance and enhancement of the accelerator complex, the primary proton beamlines, the targets and the secondary beams as well as the neutron spallation source SINQ. The division for technical support and coordination provides for technical support to the research facility complementary to the basic logistic available from the department for logistics and marketing. Besides running the facilities, the staff of the department is also involved in theoretical and experimental research projects. Some of them address basic scientific questions mainly concerning the properties of micro- or nanostructured materials: experiments as well as large scale computer simulations of molecular dynamics were performed to investigate nonclassical materials properties. Others are related to improvements or extensions of the capabilities of our facilities. We also report on intriguing results from applications of the neutron capture radiography, the prompt gamma activation method and the isotope production facility at SINQ.

  2. Colloids Versus Albumin in Large Volume Paracentesis to Prevent Circulatory Dysfunction: Evidence-based Case Report.

    Science.gov (United States)

    Widjaja, Felix F; Khairan, Paramita; Kamelia, Telly; Hasan, Irsan

    2016-04-01

    Large volume paracentesis may cause paracentesis induced circulatory dysfunction (PICD). Albumin is recommended to prevent this abnormality. Meanwhile, the price of albumin is too expensive and there should be another alternative that may prevent PICD. This report aimed to compare albumin to colloids in preventing PICD. Search strategy was done using PubMed, Scopus, Proquest, dan Academic Health Complete from EBSCO with keywords of "ascites", "albumin", "colloid", "dextran", "hydroxyethyl starch", "gelatin", and "paracentesis induced circulatory dysfunction". Articles was limited to randomized clinical trial and meta-analysis with clinical question of "In hepatic cirrhotic patient undergone large volume paracentesis, whether colloids were similar to albumin to prevent PICD". We found one meta-analysis and four randomized clinical trials (RCT). A meta analysis showed that albumin was still superior of which odds ratio 0.34 (0.23-0.51). Three RCTs showed the same results and one RCT showed albumin was not superior than colloids. We conclude that colloids could not constitute albumin to prevent PICD, but colloids still have a role in patient who undergone paracentesis less than five liters.

  3. Model checking methodology for large systems, faults and asynchronous behaviour. SARANA 2011 work report

    Energy Technology Data Exchange (ETDEWEB)

    Lahtinen, J. [VTT Technical Research Centre of Finland, Espoo (Finland); Launiainen, T.; Heljanko, K.; Ropponen, J. [Aalto Univ., Espoo (Finland). Dept. of Information and Computer Science

    2012-07-01

    Digital instrumentation and control (I and C) systems are challenging to verify. They enable complicated control functions, and the state spaces of the models easily become too large for comprehensive verification through traditional methods. Model checking is a formal method that can be used for system verification. A number of efficient model checking systems are available that provide analysis tools to determine automatically whether a given state machine model satisfies the desired safety properties. This report reviews the work performed in the Safety Evaluation and Reliability Analysis of Nuclear Automation (SARANA) project in 2011 regarding model checking. We have developed new, more exact modelling methods that are able to capture the behaviour of a system more realistically. In particular, we have developed more detailed fault models depicting the hardware configuration of a system, and methodology to model function-block-based systems asynchronously. In order to improve the usability of our model checking methods, we have developed an algorithm for model checking large modular systems. The algorithm can be used to verify properties of a model that could otherwise not be verified in a straightforward manner. (orig.)

  4. Collaborative Visualization for Large-Scale Accelerator Electromagnetic Modeling (Final Report)

    International Nuclear Information System (INIS)

    Schroeder, William J.

    2011-01-01

    This report contains the comprehensive summary of the work performed on the SBIR Phase II, Collaborative Visualization for Large-Scale Accelerator Electromagnetic Modeling at Kitware Inc. in collaboration with Stanford Linear Accelerator Center (SLAC). The goal of the work was to develop collaborative visualization tools for large-scale data as illustrated in the figure below. The solutions we proposed address the typical problems faced by geographicallyand organizationally-separated research and engineering teams, who produce large data (either through simulation or experimental measurement) and wish to work together to analyze and understand their data. Because the data is large, we expect that it cannot be easily transported to each team member's work site, and that the visualization server must reside near the data. Further, we also expect that each work site has heterogeneous resources: some with large computing clients, tiled (or large) displays and high bandwidth; others sites as simple as a team member on a laptop computer. Our solution is based on the open-source, widely used ParaView large-data visualization application. We extended this tool to support multiple collaborative clients who may locally visualize data, and then periodically rejoin and synchronize with the group to discuss their findings. Options for managing session control, adding annotation, and defining the visualization pipeline, among others, were incorporated. We also developed and deployed a Web visualization framework based on ParaView that enables the Web browser to act as a participating client in a collaborative session. The ParaView Web Visualization framework leverages various Web technologies including WebGL, JavaScript, Java and Flash to enable interactive 3D visualization over the web using ParaView as the visualization server. We steered the development of this technology by teaming with the SLAC National Accelerator Laboratory. SLAC has a computationally-intensive problem

  5. Collaborative Visualization for Large-Scale Accelerator Electromagnetic Modeling (Final Report)

    Energy Technology Data Exchange (ETDEWEB)

    William J. Schroeder

    2011-11-13

    This report contains the comprehensive summary of the work performed on the SBIR Phase II, Collaborative Visualization for Large-Scale Accelerator Electromagnetic Modeling at Kitware Inc. in collaboration with Stanford Linear Accelerator Center (SLAC). The goal of the work was to develop collaborative visualization tools for large-scale data as illustrated in the figure below. The solutions we proposed address the typical problems faced by geographicallyand organizationally-separated research and engineering teams, who produce large data (either through simulation or experimental measurement) and wish to work together to analyze and understand their data. Because the data is large, we expect that it cannot be easily transported to each team member's work site, and that the visualization server must reside near the data. Further, we also expect that each work site has heterogeneous resources: some with large computing clients, tiled (or large) displays and high bandwidth; others sites as simple as a team member on a laptop computer. Our solution is based on the open-source, widely used ParaView large-data visualization application. We extended this tool to support multiple collaborative clients who may locally visualize data, and then periodically rejoin and synchronize with the group to discuss their findings. Options for managing session control, adding annotation, and defining the visualization pipeline, among others, were incorporated. We also developed and deployed a Web visualization framework based on ParaView that enables the Web browser to act as a participating client in a collaborative session. The ParaView Web Visualization framework leverages various Web technologies including WebGL, JavaScript, Java and Flash to enable interactive 3D visualization over the web using ParaView as the visualization server. We steered the development of this technology by teaming with the SLAC National Accelerator Laboratory. SLAC has a computationally

  6. Ultra-high gain diffusion-driven organic transistor

    Science.gov (United States)

    Torricelli, Fabrizio; Colalongo, Luigi; Raiteri, Daniele; Kovács-Vajna, Zsolt Miklós; Cantatore, Eugenio

    2016-01-01

    Emerging large-area technologies based on organic transistors are enabling the fabrication of low-cost flexible circuits, smart sensors and biomedical devices. High-gain transistors are essential for the development of large-scale circuit integration, high-sensitivity sensors and signal amplification in sensing systems. Unfortunately, organic field-effect transistors show limited gain, usually of the order of tens, because of the large contact resistance and channel-length modulation. Here we show a new organic field-effect transistor architecture with a gain larger than 700. This is the highest gain ever reported for organic field-effect transistors. In the proposed organic field-effect transistor, the charge injection and extraction at the metal–semiconductor contacts are driven by the charge diffusion. The ideal conditions of ohmic contacts with negligible contact resistance and flat current saturation are demonstrated. The approach is general and can be extended to any thin-film technology opening unprecedented opportunities for the development of high-performance flexible electronics. PMID:26829567

  7. Large capillary hemangioma of the temporal bone with a dural tail sign: A case report

    KAUST Repository

    YANG, GUANG

    2014-05-13

    The present study reports a rare case of large capillary hemangioma of the temporal bone with a dural tail sign. A 57-year-old female presented with pulsatile tinnitus and episodic vertigo associated with a ten-year history of an intermittent faint headache. Magnetic resonance imaging revealed a mass in the right petrous bone, which was hypointense on T1-weighted images and heterogeneously hyperintense on T2-weighted images, and showed a dural tail sign following gadolinium administration. Pre-operatively, this tumor was believed to be a meningioma. During surgery, the vascular tumor was removed by a modified pterional approach. A histopathological examination indicated that the tumor was a capillary hemangioma. Although intraosseous capillary hemangiomas are rare, they most frequently affect the temporal bone. Hemangiomas of the temporal bone may mimic other more common basal tumors. The diagnosis is most often made during surgical resection. The dural tail sign is not specific for meningioma, as it also occurs in other intracranial or extracranial tumors. The treatment of intratemporal hemangiomas is complete surgical excision, with radiotherapy used for unresectable lesions. To the best of our knowledge, the present study is the fourth case of intraosseous intracranial capillary hemangioma, but the largest intratemporal hemangioma to be reported in the literature to date.

  8. Large capillary hemangioma of the temporal bone with a dural tail sign: A case report

    KAUST Repository

    YANG, GUANG; LI, CHENGUANG; CHEN, XIN; LIU, YAOHUA; HAN, DAYONG; Gao, Xin; KAWAMOTO, KEIJI; ZHAO, SHIGUANG

    2014-01-01

    The present study reports a rare case of large capillary hemangioma of the temporal bone with a dural tail sign. A 57-year-old female presented with pulsatile tinnitus and episodic vertigo associated with a ten-year history of an intermittent faint headache. Magnetic resonance imaging revealed a mass in the right petrous bone, which was hypointense on T1-weighted images and heterogeneously hyperintense on T2-weighted images, and showed a dural tail sign following gadolinium administration. Pre-operatively, this tumor was believed to be a meningioma. During surgery, the vascular tumor was removed by a modified pterional approach. A histopathological examination indicated that the tumor was a capillary hemangioma. Although intraosseous capillary hemangiomas are rare, they most frequently affect the temporal bone. Hemangiomas of the temporal bone may mimic other more common basal tumors. The diagnosis is most often made during surgical resection. The dural tail sign is not specific for meningioma, as it also occurs in other intracranial or extracranial tumors. The treatment of intratemporal hemangiomas is complete surgical excision, with radiotherapy used for unresectable lesions. To the best of our knowledge, the present study is the fourth case of intraosseous intracranial capillary hemangioma, but the largest intratemporal hemangioma to be reported in the literature to date.

  9. Photomultiplier gain stabilisation

    International Nuclear Information System (INIS)

    Le Baud, P.; Sautiez, B.

    1958-07-01

    By the control and adjustment of magnetic deflection applied to the electron beam of a photomultiplier it has proved possible to flatten the gain curve, forming plateaux at levels dependent upon the voltage at intake. It should be possible to add this simple device to most photomultipliers on the market today. (author) [fr

  10. FutureGen 2.0 Oxy-combustion Large Scale Test – Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Kenison, LaVesta [URS, Pittsburgh, PA (United States); Flanigan, Thomas [URS, Pittsburgh, PA (United States); Hagerty, Gregg [URS, Pittsburgh, PA (United States); Gorrie, James [Air Liquide, Kennesaw, GA (United States); Leclerc, Mathieu [Air Liquide, Kennesaw, GA (United States); Lockwood, Frederick [Air Liquide, Kennesaw, GA (United States); Falla, Lyle [Babcock & Wilcox and Burns McDonnell, Kansas City, MO (United States); Macinnis, Jim [Babcock & Wilcox and Burns McDonnell, Kansas City, MO (United States); Fedak, Mathew [Babcock & Wilcox and Burns McDonnell, Kansas City, MO (United States); Yakle, Jeff [Babcock & Wilcox and Burns McDonnell, Kansas City, MO (United States); Williford, Mark [Futuregen Industrial Alliance, Inc., Morgan County, IL (United States); Wood, Paul [Futuregen Industrial Alliance, Inc., Morgan County, IL (United States)

    2016-04-01

    be helpful to plotting the course of, and successfully executing future large demonstration projects. This Final Scientific and Technical Report describes the technology and engineering basis of the project, inclusive of process systems, performance, effluents and emissions, and controls. Further, the project cost estimate, schedule, and permitting requirements are presented, along with a project risk and opportunity assessment. Lessons-learned related to these elements are summarized in this report. Companion reports Oxy-combustion further document the accomplishments and learnings of the project, including: A.01 Project Management Report which describes what was done to coordinate the various participants, and to track their performance with regard to schedule and budget B.02 Lessons Learned - Technology Integration, Value Improvements, and Program Management, which describes the innovations and conclusions that we arrived upon during the development of the project, and makes recommendations for improvement of future projects of a similar nature . B.03 Project Economics, which details the capital and operation costs and their basis, and also illustrates the cost of power produced by the plant with certain sensitivities. B.04 Power Plant, Pipeline, and Injection Site Interfaces, which details the interfaces between the two FutureGen projects B.05 Contractual Mechanisms for Design, Construction, and Operation, which describes the major EPC, and Operations Contracts required to execute the project.

  11. A LARGE LIFE INSURANCE COMPANY AUTOMATES. WORKFORCE IMPLICATIONS OF COMPUTER CONVERSION. AUTOMATION PROGRAM REPORT, NUMBER 3.

    Science.gov (United States)

    CIBARICH, AUGUST L.; AND OTHERS

    THIS WAS ONE OF 20 DEMONSTRATION PROJECTS INITIATED IN 11 STATES IN 1961-63 TO GAIN EXPERIENCE WITH LABOR MARKET PROBLEMS ARISING FROM CHANGING TECHNOLOGY AND MASS LAYOFFS. THE FUNDAMENTAL AIM WAS TO COMBINE ACTION AND RESEARCH TO DEMONSTRATE WHAT THE STATE EMPLOYMENT SERVICE COULD DO IN AREAS WHERE THE LABOR MARKET WAS RAPIDLY CHANGING.…

  12. Sigmoid endometriosis in a post-menopausal woman leading to acute large bowel obstruction: A case report

    Directory of Open Access Journals (Sweden)

    Bardia Bidarmaghz, MD

    2016-01-01

    Conclusion: This case report shows that colonic endometriosis, although rare, can be significantly infiltrative and lead to complications such as a large bowel obstruction. Diagnosing this condition can be challenging and usually requires histological confirmation.

  13. Solar total energy: large scale experiment, Shenandoah, Georgia Site. Annual report, June 1978-June 1979

    Energy Technology Data Exchange (ETDEWEB)

    Ney, E.J.

    1979-07-01

    A background summary and a complete description of the progress and current status of activities relative to the Cooperative Agreement for the Solar Total Energy - Large Scale Experiment at the Bleyle Knitwear Plant at Shenandoah, Georgia are presented. A statement of objectives and an abstract of progress to date are included. This is followed by a short introduction containing a project overview, a summary of the participants and their respective roles, a brief description of the Solar Total Energy System (STES) design concept, and a chronological summary of progress to date. A general description of the site is given, a detailed report of progress is reported, and drawings and equipment lists are included. The closed-loop solar energy system planned for Shenandoah begins with circulation of Syltherm 800, a heat transfer fluid of the Dow-Corning Corporation, through the receiver tubes of a parabolic dish solar collector field. As solar energy is focused on the receivers, the heat transfer fluid is heated to approximately 399/sup 0/C (750/sup 0/F) and is pumped to a heat exchanger for immediate use, or to a thermal storage system for later use. Once in the heat exchanger, the fluid heats a working fluid that produces the steam required for operating the turbine. After performing this task, the heat transfer fluid returns to the collectors to repeat the cycle, while the steam turbine-generator system supplies the electrical demands for the knitwear plant and the STES. During STES operation, maximum thermal and electrical requirements of the application are expected to be at 1.08 MWth and 161 kWe, respectively. During the power generation phase, some of the steam is extracted for use as process steam in the knitwear manufacturing process, while exhaust steam from the turbine is passed through a condenser to produce hot water for heating, domestic use, and absorption air conditioning. (WHK)

  14. Learn and gain

    CERN Document Server

    Al-Alami, Suhair Eyad Jamal

    2013-01-01

    Initiating the slogan ""love it, live it"", Learn and Gain includes eight short stories, chosen to illustrate various modes of narration, as well as to provoke reflection and discussion on a range of issues. All texts utilized here illustrate how great writers can, with their insight and gift for words, help us to see the world we live in, in new probing and exciting ways. What characterises the book, the author believes, is the integration of the skills of literary competence, communicative c...

  15. Tall towers for large wind turbines. Report from Vindforsk project V-342

    Energy Technology Data Exchange (ETDEWEB)

    Engstroem, Staffan; Lyrner, Tomas; Hassanzadeh, Manouchehr; Stalin, Thomas; Johansson, John

    2010-07-15

    The general rule of thumb has been to furnish a wind turbine with a tower as tall as the turbine diameter, with deviations downwards for high wind speed sites. In this report the statement is questioned, with special emphasis for wind turbines sited in forests. The aim of this project was to propose and calculate candidate types of tall towers for on-shore wind turbines in the 3 - 5 MW range, with special reference to siting in forests with a representative wind shear. During the project this scope has been more precisely defined to study 3 and 5 MW wind turbines with hub heights of 80 - 175 meters featuring the following tower solutions: 1. Steel shell tower designed in a conventional way with flanges and both longitudinal and transverse welds. 2. Steel shell tower with bolted friction joints only. 3. Concrete tower with pretensioned steel tendons. 4. Hybrid tower with a lower concrete part and an upper part built as a conventional steel shell. 5. Lattice tower. 6. Wooden tower. During the execution of the project the design of a total of 42 towers was outlined and calculated. Today the welded steel shell tower dominates the wind turbine market. Larger turbines and higher hub heights result in larger optimal tower base diameters. For the road transportation there are limitations due to bridges and other obstacles. In Sweden the limit for transports with special permits in general maximizes the diameter to 4,5 metres. To some extent it is still technically possible to build towers with a less than optimal diameter, but due to the high mass and the large wall thickness they tend to be uneconomical in comparison with other alternatives above a hub height of roughly 100 metres. In this report welded steel shell towers were outlined for 3 MW turbines up to a hub height of 150 metres whereas the limit for the 5 MW towers was 100 metres. When diameter restrictions tend to make welded towers uneconomical, the next logical choice is steel shell towers with bolted friction

  16. LARGE DENTIGEROUS CYST IN THE MAXILLARY SINUS LEADING TO DIPLOPIA AND NASAL OBSTRUCTION: CASE REPORT*

    Directory of Open Access Journals (Sweden)

    M. İsa KARA

    2015-04-01

    Full Text Available Dentigerous cysts are the most common developmental odontogenic cyst of the jaws. They are more frequent in males and although most often affected teeth are maxillary canines and mandibular third molars, they may also be related with supernumerary or an ectopically erupted tooth. Our aim was to report the management of ectopic third molar tooth related with a dentigerous cyst in maxillary sinus. 16 years old girl referred to our clinic with a complaint of painful swelling over her right cheek since past six months. All permanent teeth were present except the right upper third molar. External examination showed that the face was gently asymmetrical; levels of eye globes were abnormal. Radiographic examination revealed a cystic lesion related with ectopic third molar which located in the roof of the left maxillary sinus. Under local anesthesia, hard drain was inserted into the hole and the cystic pressure was decreased. After the six month of followup, the operation was performed under general anesthesia. The patient’s symptoms were resolved completely after surgery and remained symptom-free for over a postoperative follow-up period of 3 year. To avoid unwanted effects of a dentigerous cyst, unerupted tooth should be observed with radiographic imaging. Some untreated dentigerous cysts may grow large and have a potential to develop into an odontogenic tumor.

  17. Large scale gas injection test (Lasgit) performed at the Aespoe Hard Rock Laboratory. Summary report 2008

    International Nuclear Information System (INIS)

    Cuss, R.J.; Harrington, J.F.; Noy, D.J.

    2010-02-01

    This report describes the set-up, operation and observations from the first 1,385 days (3.8 years) of the large scale gas injection test (Lasgit) experiment conducted at the Aespoe Hard Rock Laboratory. During this time the bentonite buffer has been artificially hydrated and has given new insight into the evolution of the buffer. After 2 years (849 days) of artificial hydration a canister filter was identified to perform a series of hydraulic and gas tests, a period that lasted 268 days. The results from the gas test showed that the full-scale bentonite buffer behaved in a similar way to previous laboratory experiments. This confirms the up-scaling of laboratory observations with the addition of considerable information on the stress responses throughout the deposition hole. During the gas testing stage, the buffer was continued to artificially hydrate. Hydraulic results, from controlled and uncontrolled events, show that the buffer continues to mature and has yet to reach full maturation. Lasgit has yielded high quality data relating to the hydration of the bentonite and the evolution in hydrogeological properties adjacent to the deposition hole. The initial hydraulic and gas injection tests confirm the correct working of all control and data acquisition systems. Lasgit has been in successful operation for in excess of 1,385 days

  18. Large scale gas injection test (Lasgit) performed at the Aespoe Hard Rock Laboratory. Summary report 2008

    Energy Technology Data Exchange (ETDEWEB)

    Cuss, R.J.; Harrington, J.F.; Noy, D.J. (British Geological Survey (United Kingdom))

    2010-02-15

    This report describes the set-up, operation and observations from the first 1,385 days (3.8 years) of the large scale gas injection test (Lasgit) experiment conducted at the Aespoe Hard Rock Laboratory. During this time the bentonite buffer has been artificially hydrated and has given new insight into the evolution of the buffer. After 2 years (849 days) of artificial hydration a canister filter was identified to perform a series of hydraulic and gas tests, a period that lasted 268 days. The results from the gas test showed that the full-scale bentonite buffer behaved in a similar way to previous laboratory experiments. This confirms the up-scaling of laboratory observations with the addition of considerable information on the stress responses throughout the deposition hole. During the gas testing stage, the buffer was continued to artificially hydrate. Hydraulic results, from controlled and uncontrolled events, show that the buffer continues to mature and has yet to reach full maturation. Lasgit has yielded high quality data relating to the hydration of the bentonite and the evolution in hydrogeological properties adjacent to the deposition hole. The initial hydraulic and gas injection tests confirm the correct working of all control and data acquisition systems. Lasgit has been in successful operation for in excess of 1,385 days

  19. Treatment of Large Periapical Cyst Like Lesion: A Noninvasive Approach: A Report of Two Cases.

    Science.gov (United States)

    Sood, Nikhil; Maheshwari, Neha; Gothi, Rajat; Sood, Niti

    2015-01-01

    Periapical lesions develop as sequelae to pulp disease. Periapical radiolucent areas are generally diagnosed either during routine dental radiographic examination or following acute toothache. Various methods can be used in the nonsurgical management of periapical lesions: the conservative root canal treatment, decompression technique, active nonsurgical decompression technique, aspiration-irrigation technique, method using calcium hydroxide, lesion sterilization and repair therapy and the apexum procedure. Monitoring the healing of periapical lesions is essential through periodic follow-up examinations. The ultimate goal of endodontic therapy should be to return the involved teeth to a state of health and function without surgical intervention. All inflammatory periapical lesions should be initially treated with conservative nonsurgical procedures. Surgical intervention is recommended only after nonsurgical techniques have failed. Besides, surgery has many drawbacks, which limit its use in the management of periapical lesions. How to cite this article: Sood N, Maheshwari N, Gothi R, Sood N. Treatment of Large Periapical Cyst Like Lesion: A Noninvasive Approach: A Report of Two Cases. Int J Clin Pediatr Dent 2015;8(2):133-137.

  20. Gains from quota trade

    DEFF Research Database (Denmark)

    Andersen, Jesper Levring; Bogetoft, Peter

    2007-01-01

    We provide a framework for evaluating potential effects of introducing tradable quotas to a sector. The effects depend on the economies of scale and scope of the production technology, and on firms' ability and willingness to learn best practice methods (catching up) and to change their input...... and output composition (mix). To illustrate our approach, data from the Danish fishery are used to calculate the potential gains from introducing individually transferable fishing quotas. Data envelopment analysis is used to model the production technology. We find that pure reallocation is as important...

  1. Gaining Relational Competitive Advantages

    DEFF Research Database (Denmark)

    Hu, Yimei; Zhang, Si; Li, Jizhen

    2015-01-01

    Establishing strategic technological partnerships (STPs) with foreign partners is an increasingly studied topic within the innovation management literature. Partnering firms can jointly create sources of relational competitive advantage. Chinese firms often lack research and development (R......&D) capabilities but are increasingly becoming preferred technological partners for transnational corporations. We investigate an STP between a Scandinavian and a Chinese firm and try to explore how to gain relational competitive advantage by focusing on its two essential stages: relational rent generation...... and appropriation. Based on an explorative case study, we develop a conceptual framework that consists of process, organizational alliance factors, and coordination modes that we propose lead to relational competitive advantage....

  2. Anaplastic large cell lymphoma of the breast arising around mammary implant capsule: an Italian report.

    Science.gov (United States)

    Farace, Francesco; Bulla, Antonio; Marongiu, Francesco; Campus, Gian Vittorio; Tanda, Francesco; Lissia, Amelia; Cossu, Antonio; Fozza, Claudio; Rubino, Corrado

    2013-06-01

    Anaplastic large cell lymphoma (ALCL) of the breast is a very rare nonepithelial neoplasm. In the literature, this tumor has sometimes been described in proximity of breast implants (60 implant-related ALCL reported). In 2010, a patient who had undergone a right mastectomy and tissue expander/implant reconstruction for a "ductal" carcinoma 10 years before was referred to our unit for evaluation. On examination, an enlarged reconstructed right breast was found. The reconstructed breast did not show tenderness or signs of infection, ulceration, or breakdown. Mammograms and ultrasound scan did not suggest the presence of recurrent cancer, infection, deflation of the implant, or severe capsule contracture. The patient underwent mammary implant replacement. About 3 weeks after surgery, the patient came back to our unit for a new mild enlargement of the operated breast and the implant was removed. Three months later, the patient returned with a skin lesion in the right parasternal region. A radical excisional biopsy was performed under local anesthesia and the diagnosis of ALK-1-negative ALCL was finally made. The clinical and histological diagnosis of this disease is difficult as it can often be mistaken for a simple seroma (breast enlargement), an infection, or an unspecific reaction to silicone (redness and/or tension of the skin, itching, and fever). We strongly suggest considering ALCL in any patient with a spontaneous breast seroma lasting more than 6 months after mammary prosthesis implantation. The suspicion of ALCL must be suggested to the pathologist immediately. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

  3. Paul Scherrer Institute Scientific Report 1998. Volume VI: Large Research Facilities

    International Nuclear Information System (INIS)

    Bauer, Guenter; Bercher, Renate; Buechli, Carmen; Foroughi, Fereydoun; Meyer, Rosa

    1999-01-01

    The department GFA (Grossforschungsanlagen, Large Research Facilities) has been established in October 1998 and its main duty is operation, maintenance and development of the PSI accelerators, the spallation neutron source and the beam transport systems for pions and muons. A large effort of this group concerns the planning and co-ordination of the assembly of the Swiss Light Source (SLS). (author)

  4. The Effect of Board Independence on the Sustainability Reporting Practices of Large U.S. Firms \\

    Directory of Open Access Journals (Sweden)

    David N. Herda

    2012-12-01

    firms with a greater proportion of independent board members are: 1 more likely to publish standalone sustainability reports, and 2 more likely to publish higher quality sustainability reports. This paper contributes to prior literature that reports somewhat mixed results on the effect of board independence on voluntary disclosure.

  5. Parent and adolescent reports in assessing adolescent sleep problems: results from a large population study.

    Science.gov (United States)

    Fatima, Yaqoot; Doi, Suhail A R; O'Callaghan, Michael; Williams, Gail; Najman, Jake M; Mamun, Abdullah Al

    2016-09-01

    To compare parent and adolescent reports in exploring adolescent sleep problems and to identify the factors associated with adolescent sleep problem disclosures. Parent (n = 5185) and adolescent reports (n = 5171, age=13.9 ± 0.3 years), from a birth cohort were used to explore adolescent sleep problems. Kappa coefficients were used to assess the agreement, whereas, conditional agreement and disagreement ratios were used to identify the optimal informant. Logistic regression analysis was used to determine the factors affecting adolescent sleep problem disclosure. Parental reports identified only about one-third of the sleep problems reported by adolescents. Whereas adolescent reports identified up to two-thirds of the sleep problems reported by parents. Combined reports of parents and adolescent did not show any considerable difference from the adolescent report. Adolescent and parent health, maternal depression, and family communication were significantly associated with adolescents sleep problem disclosures. Adolescent reports could be used as the preferred source to explore adolescent sleep problems. Parental reports should be used when parents as observers are more reliable reporters, or where adolescents are cognitively unable to report sleep problems. Additionally, the impact of poor health, maternal depression and family communication on sleep problems disclosure should be considered for adolescent sleep problem diagnosis. ©2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  6. Evaluation of a Web-based Error Reporting Surveillance System in a Large Iranian Hospital.

    Science.gov (United States)

    Askarian, Mehrdad; Ghoreishi, Mahboobeh; Akbari Haghighinejad, Hourvash; Palenik, Charles John; Ghodsi, Maryam

    2017-08-01

    Proper reporting of medical errors helps healthcare providers learn from adverse incidents and improve patient safety. A well-designed and functioning confidential reporting system is an essential component to this process. There are many error reporting methods; however, web-based systems are often preferred because they can provide; comprehensive and more easily analyzed information. This study addresses the use of a web-based error reporting system. This interventional study involved the application of an in-house designed "voluntary web-based medical error reporting system." The system has been used since July 2014 in Nemazee Hospital, Shiraz University of Medical Sciences. The rate and severity of errors reported during the year prior and a year after system launch were compared. The slope of the error report trend line was steep during the first 12 months (B = 105.727, P = 0.00). However, it slowed following launch of the web-based reporting system and was no longer statistically significant (B = 15.27, P = 0.81) by the end of the second year. Most recorded errors were no-harm laboratory types and were due to inattention. Usually, they were reported by nurses and other permanent employees. Most reported errors occurred during morning shifts. Using a standardized web-based error reporting system can be beneficial. This study reports on the performance of an in-house designed reporting system, which appeared to properly detect and analyze medical errors. The system also generated follow-up reports in a timely and accurate manner. Detection of near-miss errors could play a significant role in identifying areas of system defects.

  7. Paul Scherrer Institute Scientific Report 1998. Volume VI: Large Research Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, Guenter; Bercher, Renate; Buechli, Carmen; Foroughi, Fereydoun; Meyer, Rosa [eds.

    1999-09-01

    The department GFA (Grossforschungsanlagen, Large Research Facilities) has been established in October 1998 and its main duty is operation, maintenance and development of the PSI accelerators, the spallation neutron source and the beam transport systems for pions and muons. A large effort of this group concerns the planning and co-ordination of the assembly of the Swiss Light Source (SLS). (author) figs., tabs., refs.

  8. High gain semiconductor optical amplifier — Laser diode at visible wavelength

    KAUST Repository

    Shen, Chao; Lee, Changmin; Ng, Tien Khee; Nakamura, Shuji; Speck, James S.; DenBaars, Steven P.; Alyamani, Ahmed Y.; El-Desouki, Munir M.; Ooi, Boon S.

    2017-01-01

    We reported on the first experimental demonstration of a two-section semipolar InGaN-based laser diode with monolithically integrated semiconductor optical amplifier (SOA-LD). The onset of amplification effect was measured at 4V SOA bias (VSOA). The SOA-LD shows a large gain of 5.32 dB at Vsoa = 6 V.

  9. High gain semiconductor optical amplifier — Laser diode at visible wavelength

    KAUST Repository

    Shen, Chao

    2017-02-07

    We reported on the first experimental demonstration of a two-section semipolar InGaN-based laser diode with monolithically integrated semiconductor optical amplifier (SOA-LD). The onset of amplification effect was measured at 4V SOA bias (VSOA). The SOA-LD shows a large gain of 5.32 dB at Vsoa = 6 V.

  10. Primary cutaneous large B-cell lymphoma of scalp: Case report of a rare variant

    Directory of Open Access Journals (Sweden)

    Yasmeen Khatib

    2017-01-01

    Full Text Available Primary cutaneous large B-cell lymphoma (Bcl is defined as a lymphoma composed of large cells constituting more than 80% of the infiltrate and absence of extracutaneous involvement after staging investigations. In the new World Health Organization/European Organization for Research and Treatment of Cancer classification, cutaneous Bcls with large cells are of three types - primary cutaneous large Bcl leg type (PCLBCLLT, primary cutaneous follicle center lymphoma diffuse type (PCFCLDT, and primary cutaneous large Bcls other (PCLBCLO. These three different types are distinct in terms of their clinicopathological features and survival. The PCLBCLO has intermediate features between those of PCLBCLLT and PCFCLDT. We present a case of PCLBCLO in a 57-year-old male who presented with a scalp swelling. Ultrasonography examination was suggestive of a sebaceous cyst. Computed tomography scan revealed the presence of an ill-defined hyperdense region in the soft tissue of the scalp region extending into the deeper layers of the scalp. Fine-needle aspiration cytology (FNAC revealed the presence of atypical lymphoid cells. Diagnosis was confirmed by biopsy and immunohistochemistry. Patient received rituximab combined with doxorubicin, vincristine, cyclophosphamide, and prednisolone regimen with complete resolution of the lesion. We present this case for its rarity, the utility of FNAC in early diagnosis, and to discuss the differential diagnosis.

  11. Report of the Workshop on Petascale Systems Integration for LargeScale Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, William T.C.; Walter, Howard; New, Gary; Engle, Tom; Pennington, Rob; Comes, Brad; Bland, Buddy; Tomlison, Bob; Kasdorf, Jim; Skinner, David; Regimbal, Kevin

    2007-10-01

    There are significant issues regarding Large Scale System integration that are not being addressed in other forums such as current research portfolios or vendor user groups. Unfortunately, the issues in the area of large-scale system integration often fall into a netherworld; not research, not facilities, not procurement, not operations, not user services. Taken together, these issues along with the impact of sub-optimal integration technology means the time required to deploy, integrate and stabilize large scale system may consume up to 20 percent of the useful life of such systems. Improving the state of the art for large scale systems integration has potential to increase the scientific productivity of these systems. Sites have significant expertise, but there are no easy ways to leverage this expertise among them . Many issues inhibit the sharing of information, including available time and effort, as well as issues with sharing proprietary information. Vendors also benefit in the long run from the solutions to issues detected during site testing and integration. There is a great deal of enthusiasm for making large scale system integration a full-fledged partner along with the other major thrusts supported by funding agencies in the definition, design, and use of a petascale systems. Integration technology and issues should have a full 'seat at the table' as petascale and exascale initiatives and programs are planned. The workshop attendees identified a wide range of issues and suggested paths forward. Pursuing these with funding opportunities and innovation offers the opportunity to dramatically improve the state of large scale system integration.

  12. Workshop Report on Additive Manufacturing for Large-Scale Metal Components - Development and Deployment of Metal Big-Area-Additive-Manufacturing (Large-Scale Metals AM) System

    Energy Technology Data Exchange (ETDEWEB)

    Babu, Sudarsanam Suresh [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Manufacturing Demonstration Facility; Love, Lonnie J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Manufacturing Demonstration Facility; Peter, William H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Manufacturing Demonstration Facility; Dehoff, Ryan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Manufacturing Demonstration Facility

    2016-05-01

    Additive manufacturing (AM) is considered an emerging technology that is expected to transform the way industry can make low-volume, high value complex structures. This disruptive technology promises to replace legacy manufacturing methods for the fabrication of existing components in addition to bringing new innovation for new components with increased functional and mechanical properties. This report outlines the outcome of a workshop on large-scale metal additive manufacturing held at Oak Ridge National Laboratory (ORNL) on March 11, 2016. The charter for the workshop was outlined by the Department of Energy (DOE) Advanced Manufacturing Office program manager. The status and impact of the Big Area Additive Manufacturing (BAAM) for polymer matrix composites was presented as the background motivation for the workshop. Following, the extension of underlying technology to low-cost metals was proposed with the following goals: (i) High deposition rates (approaching 100 lbs/h); (ii) Low cost (<$10/lbs) for steel, iron, aluminum, nickel, as well as, higher cost titanium, (iii) large components (major axis greater than 6 ft) and (iv) compliance of property requirements. The above concept was discussed in depth by representatives from different industrial sectors including welding, metal fabrication machinery, energy, construction, aerospace and heavy manufacturing. In addition, DOE’s newly launched High Performance Computing for Manufacturing (HPC4MFG) program was reviewed. This program will apply thermo-mechanical models to elucidate deeper understanding of the interactions between design, process, and materials during additive manufacturing. Following these presentations, all the attendees took part in a brainstorming session where everyone identified the top 10 challenges in large-scale metal AM from their own perspective. The feedback was analyzed and grouped in different categories including, (i) CAD to PART software, (ii) selection of energy source, (iii

  13. The effects of control-display gain on performance of race car drivers in an isometric braking task.

    Science.gov (United States)

    de Winter, J C F; de Groot, S

    2012-12-01

    To minimise lap times during car racing, it is important to build up brake forces rapidly and maintain precise control. We examined the effect of the amplification factor (gain) between brake pedal force and a visually represented output value on a driver's ability to track a target value. The test setup was a formula racing car cockpit fitted with an isometric brake pedal. Thirteen racing drivers performed tracking tasks with four control-display gains and two target functions: a step function (35 trials per gain) and a multisine function (15 trials per gain). The control-display gain had only minor effects on root mean-squared error between output value and target value, but it had large effects on build-up speed, overshoot, within-participants variability, and self-reported physical load. The results confirm the hypothesis that choosing an optimum gain involves balancing stability against physical effort.

  14. Personality type influence the gestational weight gain.

    Science.gov (United States)

    Franik, Grzegorz; Lipka, Nela; Kopyto, Katarzyna; Kopocińska, Joanna; Owczarek, Aleksander; Sikora, Jerzy; Madej, Paweł; Chudek, Jerzy; Olszanecka-Glinianowicz, Magdalena

    2017-08-01

    Pregnancy is frequently followed by the development of obesity. Aside from psychological factors, hormonal changes influence weight gain in pregnant women. We attempted to assess the potential association between personality type and the extent of gestational weight gain. The study group involved 773 women after term delivery (age 26.3 ± 3.9 years, body mass before pregnancy 61.2 ± 11.1 kg). Weight gain during pregnancy was calculated by using self-reported body mass prior to and during the 38th week of pregnancy. Personality type was assessed using the Polish version of the Framingham Type A Behavior Patterns Questionnaire (adapted by Juczynski). Two hundred forty-six (31.8%) study subjects represented type A personalities, 272 (35.2%) type B and 255 (33.0%) an indirect type. Gestational weight gain was related to the behavior patterns questionnaire score and age. In women gain was higher than in women with type B behavior of the same age. In women >30, the gestational weight gain was larger for type B personalities. Type A personality and increased urgency in younger pregnant women increases the risk of developing obesity during pregnancy in women below 30 years old. A higher level of competitiveness demonstrates a risk factor of excessive weight gain during pregnancy regardless of age.

  15. Large gastrointestinal stromal tumor and advanced adenocarcinoma in the rectum coexistent with an incidental prostate carcinoma: A case report

    Directory of Open Access Journals (Sweden)

    Toshiaki Suzuki

    2014-01-01

    CONCLUSION: Radical surgery with perioperative adjuvant chemotherapy using tyrosine kinase inhibitors is the choice for treatment of large GISTs with a malignant potential. Our report suggests that aggressive surgical approach would be feasible, when a secondary tumor is present near the GIST.

  16. Report of the Working Group on Large-Scale Computing in Aeronautics.

    Science.gov (United States)

    1984-06-01

    function and the use of drawings. In the hardware area, comtemporary large computer installations are quite powerful in terms of speed of computation as...critical to the competitive advantage of that member. He might then be willing to make them available to less advanced members under some business

  17. Paul Scherrer Institut annual report 1996. Annex IIIA: solid state research at large facilities

    Energy Technology Data Exchange (ETDEWEB)

    Baltensperger, U; Lorenzen, R [eds.; Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1997-09-01

    A progress report is given on research performed during 1996 in the fields of the spallation neutron source, ion beam physics, radio- and environmental chemistry, neutron scattering and astrophysics. figs., tabs., refs.

  18. Final Report: Large-Scale Optimization for Bayesian Inference in Complex Systems

    Energy Technology Data Exchange (ETDEWEB)

    Ghattas, Omar [The University of Texas at Austin

    2013-10-15

    The SAGUARO (Scalable Algorithms for Groundwater Uncertainty Analysis and Robust Optimiza- tion) Project focuses on the development of scalable numerical algorithms for large-scale Bayesian inversion in complex systems that capitalize on advances in large-scale simulation-based optimiza- tion and inversion methods. Our research is directed in three complementary areas: efficient approximations of the Hessian operator, reductions in complexity of forward simulations via stochastic spectral approximations and model reduction, and employing large-scale optimization concepts to accelerate sampling. Our efforts are integrated in the context of a challenging testbed problem that considers subsurface reacting flow and transport. The MIT component of the SAGUARO Project addresses the intractability of conventional sampling methods for large-scale statistical inverse problems by devising reduced-order models that are faithful to the full-order model over a wide range of parameter values; sampling then employs the reduced model rather than the full model, resulting in very large computational savings. Results indicate little effect on the computed posterior distribution. On the other hand, in the Texas-Georgia Tech component of the project, we retain the full-order model, but exploit inverse problem structure (adjoint-based gradients and partial Hessian information of the parameter-to- observation map) to implicitly extract lower dimensional information on the posterior distribution; this greatly speeds up sampling methods, so that fewer sampling points are needed. We can think of these two approaches as "reduce then sample" and "sample then reduce." In fact, these two approaches are complementary, and can be used in conjunction with each other. Moreover, they both exploit deterministic inverse problem structure, in the form of adjoint-based gradient and Hessian information of the underlying parameter-to-observation map, to achieve their speedups.

  19. Can LENR Energy Gains Exceed 1000?

    Science.gov (United States)

    Nagel, David J.

    2011-03-01

    Energy gain is defined as the energy realized from reactions divided by the energy required to produce those reactions. Low Energy Nuclear Reactions (LENR) have already been measured to significantly exceed the energy gain of 10 projected from ITER,possibly 15 years from now. Electrochemical experiments using the Pd-D system have shown energy gains exceeding 10. Gas phase experiments with the Ni-H system were reported to yield energy gains of over 100. Neither of these reports has been adequately verified or reproduced. However, the question in the title still deserves consideration. If, as thought by many, it is possible to trigger nuclear reactions that yield MeV energies with chemical energies of the order of eV, then the most optimistic expectation is that LENR gains could approach one million. Hence, the very tentative answer to the question above is yes. However, if LENR could be initiated with some energy cost, and then continue to ``burn,'' very high energy gains might be realized. Consider a match and a pile of dry logs. The phenomenon termed ``heat after death'' will be examined to see if it might be the initial evidence for nuclear ``burning.''

  20. The Biology of Intron Gain and Loss

    DEFF Research Database (Denmark)

    Jeffares, Daniel C; Mourier, Tobias; Penny, David

    2006-01-01

    Intron density in eukaryote genomes varies by more than three orders of magnitude, so there must have been extensive intron gain and/or intron loss during evolution. A favored and partial explanation for this range of intron densities has been that introns have accumulated stochastically in large...... on introns depending on the biology of the organism and the gene involved....

  1. Leaving home for college and gaining independence

    NARCIS (Netherlands)

    Mulder, C.H.; Clark, W.A.V.

    2002-01-01

    As more and more young US adults attend college it has become an increasingly important filter in the process of becoming an independent household. Now for a large number of young adults living in the USA, living away at college is a first step in the process of gaining residential and economic

  2. A large uterine leiomyoma leading to non-puerperal uterine inversion: A case report

    Directory of Open Access Journals (Sweden)

    Batool Teimoori

    2017-08-01

    Full Text Available Background: Although leiomyomas are the most common gynecologic disorders, non-puerperal uterine inversion due to leiomyoma is considered as a rare clinical problem. This condition can occur as a complication of a large sub-mucous leiomyoma that leads to dilate cervix and protrude into vagina. The patient may have several symptoms such as heavy vaginal bleeding, pelvic pain and intermittent acute urinary retention. Case: We presented a 32-year-old nulliparous woman with 17 years of unexplained infertility and diagnosis of a large vaginal prolapsed non-pedunculated leiomyoma. Conclusion: Haultain’s procedure was used to reposition uterine inversion and remove leiomyoma through a posterior incision, using laparotomy

  3. Anaesthetic management in a case of large plunging ranula with difficult airway: A case report

    Directory of Open Access Journals (Sweden)

    Surendra Kumar Sethi

    2017-04-01

    Full Text Available Plunging ranula is a mucous retention cyst found on the floor of mouth which arises from the submandibular and sublingual salivary glands extending to lateral aspect of neck, which may often cause potential airway obstruction leading to difficulty in airway management. A forty year old female patient was admitted to our hospital with large, painless swelling in the floor of mouth extending to the lateral part of body of mandible and neck. This intraoral swelling distorted the normal airway anatomy thus making airway management difficult as the patient was planned for excision of swelling under general anaesthesia. So we present a case of successful management of a difficult airway by using awake fibre optic intubation in a patient posted for excision of a large plunging ranula under general anaesthesia.

  4. Improved design for large wind turbine blades of fibre composites (Phase 4) - Summary report

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, B.F.; Toftegaard, H.; Goutanos, S. (Risoe DTU, Materials Research Div., Roskilde (Denmark)); Branner, K.; Berring, P. (Risoe DTU, Wind Energy Div., Roskilde (Denmark)); Lund, E. (Aalborg Univ., Dept. of Mechanical Engineering, Aalborg (Denmark)); Wedel-Heinen, J. (Vestas Wind System, Randers (Denmark)); Garm, J.H. (LM Wind Power, Kolding (Denmark))

    2010-06-15

    Results are summarised for the project 'Improved design for large wind turbine blades (Phase 4)', partially supported by the Danish Energy Agency under the Ministry of Climate and Energy through the EUDP journal no.: 33033-0267. The aim of the project was to develop new and better design methods for wind turbine blades, so that uncertainties associated with damage and defects can be reduced. The topics that are studied include buckling-driven delamination of flat load-carrying laminates, cracking along interfaces in material joints (fracture mechanical characterisation and modelling), cyclic crack growth with large scale bridging and the use of cohesive laws in finite element programmes for simulating wind turbine blade failure. An overview is given of the methods and the major research results of the project. The implementation of the knowledge in the industry is discussed. Finally, some ideas for future research activities are considered. (author)

  5. Laparoscopic management of a large ovarian cyst in an adolescent. A case report.

    Science.gov (United States)

    Eltabbakh, G H; Kaiser, J R

    2000-03-01

    The safety of laparoscopic management of benign ovarian cysts has been demonstrated. The size of the benign ovarian cyst continues to be a limiting factor for laparoscopic surgery, with most surgeons choosing laparotomy for large cysts. A 15-year-old woman had a 22-cm, benign ovarian cyst extending above the umbilicus that was managed successfully with laparoscopy. We performed prelaparoscopy cyst drainage with a suprapubic Bonanno catheter (Becton Dickinson, Rutherford, New Jersey) followed by laparoscopic cystectomy. Because of its coiled end, the Bonanno catheter is less likely to result in cyst leakage around the aspiration site. With proper patient selection, laparoscopic surgery can be safely applied in a select group of patients with large, benign ovarian cysts.

  6. Hardware concepts for a large low-energetics LMFBR core. Final report

    International Nuclear Information System (INIS)

    Hutter, E.; Batch, R.V.

    1980-12-01

    A design study was made to identify a practical set of hardware configurations that would embody the requirements developed in the numerical study of a low-energetics core and blanket for a prototype large breeder reactor. Dimensioned drawings are presented for fuel, blanket, reflector/shield, and control rod subassemblies. A horizontal cross section drawing shows how these subassemblies are arranged in the total core/blanket assembly. A core support is illustrated showing a dual plenums arrangement

  7. Potential gains from hospital mergers in Denmark.

    Science.gov (United States)

    Kristensen, Troels; Bogetoft, Peter; Pedersen, Kjeld Moeller

    2010-12-01

    The Danish hospital sector faces a major rebuilding program to centralize activity in fewer and larger hospitals. We aim to conduct an efficiency analysis of hospitals and to estimate the potential cost savings from the planned hospital mergers. We use Data Envelopment Analysis (DEA) to estimate a cost frontier. Based on this analysis, we calculate an efficiency score for each hospital and estimate the potential gains from the proposed mergers by comparing individual efficiencies with the efficiency of the combined hospitals. Furthermore, we apply a decomposition algorithm to split merger gains into technical efficiency, size (scale) and harmony (mix) gains. The motivation for this decomposition is that some of the apparent merger gains may actually be available with less than a full-scale merger, e.g., by sharing best practices and reallocating certain resources and tasks. Our results suggest that many hospitals are technically inefficient, and the expected "best practice" hospitals are quite efficient. Also, some mergers do not seem to lower costs. This finding indicates that some merged hospitals become too large and therefore experience diseconomies of scale. Other mergers lead to considerable cost reductions; we find potential gains resulting from learning better practices and the exploitation of economies of scope. To ensure robustness, we conduct a sensitivity analysis using two alternative returns-to-scale assumptions and two alternative estimation approaches. We consistently find potential gains from improving the technical efficiency and the exploitation of economies of scope from mergers.

  8. Physics gains attraction?

    Science.gov (United States)

    2000-01-01

    A recent report from the American Institute of Physics has indicated that high school enrolments in physics in the USA have reached their highest level since World War II. Figures for the last decade show an increase in the proportion of high school students taking physics from 20 to 28% (800Â 000 students now), according to Physics Today (October 1999, p 68). The report, Maintaining Momentum: High School Physics for a New Millennium , was based on a 1997 survey of high school physics teachers, the fourth such since the mid-1980s. One conclusion drawn by the report's authors was that a broader range of physics courses is now offered, with increased popularity of `conceptual' physics courses using little algebra or trigonometry over the last ten years. The proportion of students with the strongest maths abilities now taking advanced placement or second-year physics has doubled since 1987. In addition the physics appeal has been noted among high school girls, where the percentage taking physics has risen from 39 to 47% in the ten years to 1997. These female students do not, however, seem to extend their studies into advanced placements or even into teaching physics (women constitute just a quarter of high school teachers of the subject). Sadly the good news is outweighed by the fact that physics still registers the lowest enrolments of all the high school sciences - about half those in chemistry for example. Indeed only around 1% of high school students have taken two years of physics before they graduate, which represents a much lower proportion than in many European and Asian countries. The full report can be viewed at the AIP's statistics division's homepage: www.aip.org/statistics/trends/hstrends.htm whilst summaries of the document are available free from the AIP, Education and Employment Statistics Division, One Physics Ellipse, College Park, MD 20740, USA.

  9. Pulmonary vasculitis may obscure large cell lung carcinoma. A case report

    NARCIS (Netherlands)

    Kreeftenberg, HG; Ligtenberg, JJM; van der Werf, TS; Timens, W; Tervaert, JWC

    2001-01-01

    Several vasculitic syndromes are recognized as paraneoplastic symdromes of an underlying malignant disease. Most frequently small vessel vasculitis of the skin has been reported. We describe the case of a 62-year-old man with a pulmonary mass due to pulmonary vasculitis. After resection of the

  10. Workshop report on large-scale matrix diagonalization methods in chemistry theory institute

    Energy Technology Data Exchange (ETDEWEB)

    Bischof, C.H.; Shepard, R.L.; Huss-Lederman, S. [eds.

    1996-10-01

    The Large-Scale Matrix Diagonalization Methods in Chemistry theory institute brought together 41 computational chemists and numerical analysts. The goal was to understand the needs of the computational chemistry community in problems that utilize matrix diagonalization techniques. This was accomplished by reviewing the current state of the art and looking toward future directions in matrix diagonalization techniques. This institute occurred about 20 years after a related meeting of similar size. During those 20 years the Davidson method continued to dominate the problem of finding a few extremal eigenvalues for many computational chemistry problems. Work on non-diagonally dominant and non-Hermitian problems as well as parallel computing has also brought new methods to bear. The changes and similarities in problems and methods over the past two decades offered an interesting viewpoint for the success in this area. One important area covered by the talks was overviews of the source and nature of the chemistry problems. The numerical analysts were uniformly grateful for the efforts to convey a better understanding of the problems and issues faced in computational chemistry. An important outcome was an understanding of the wide range of eigenproblems encountered in computational chemistry. The workshop covered problems involving self- consistent-field (SCF), configuration interaction (CI), intramolecular vibrational relaxation (IVR), and scattering problems. In atomic structure calculations using the Hartree-Fock method (SCF), the symmetric matrices can range from order hundreds to thousands. These matrices often include large clusters of eigenvalues which can be as much as 25% of the spectrum. However, if Cl methods are also used, the matrix size can be between 10{sup 4} and 10{sup 9} where only one or a few extremal eigenvalues and eigenvectors are needed. Working with very large matrices has lead to the development of

  11. Primary Cutaneous Diffuse Large B-Cell Lymphoma – a Case Report

    Directory of Open Access Journals (Sweden)

    Milovanović Milena

    2017-06-01

    Full Text Available In 2005, the World Health Organization - European Organization for Research and Treatment of Cancer (WHOEORTC classified cutaneous B-cell lymphomas into 4 categories: primary cutaneous marginal zone B-cell lymphoma (PCMZL, primary cutaneous follicle center lymphoma (PCFCL, primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT, and primary cutaneous diffuse large B-cell lymphoma, other (PCDLBCL-O. The absence of evident extra-cutaneous disease is a necessary condition for the diagnosis of primary cutaneous B-cell lymphomas, because they have a completely different clinical behavior and prognosis from their nodal counterparts. PCDLBCL-O basically represents a morphological variation, lacking the typical features of PCDLBCLLT, neither confirming the definition of PCFCCL, but on the clinical ground, its behavior seems at least to partially overlap the indolent course of PCFCCL. In fact, the present WHO lymphoma classification from 2008 overcame the previous WHO-EORTC classification, including at least a part of PCDLBCL-O within the spectrum of PCFCCL. However, owing to the rarity and heterogeneity of the PCDLBCL-O, the precise clinicopathological characteristics have not been well characterized and the optimal treatment for this group of lymphomas is yet to be defined. Nevertheless, dermatologists and pathologists should be aware of this entity in order to avoid unnecessary aggressive treatment. We present a case of a 46-year-old Caucasian male with one large round-shaped tumor and a few scattered nodules localized on the back. The histopathological features of the lesion corresponded to PCDLBCL-O. The patient follow-up showed that he was disease-free three months after surgical excision of the lesions and adjuvant local radiotherapy. No additional therapy was introduced, including chemotherapy with rituximab, cyclophosphamide, doxorubicin hydrochloride, oncovin, prednisolone (R-CHOP.

  12. Improved design of large wind turbine blades of fibre composites (Phase 2) - Summary Report

    DEFF Research Database (Denmark)

    Sørensen, Bent F.; Branner, K.; Stang, H.

    2005-01-01

    girder section subjected to transverse forces was investigated experimentally and by modelling. Buckling-driven delamination of planar specimens was studied on experimentally and by modelling. A novel approachwas proposed for the determination of mixed mode cohesive laws for large-scale crack bridging...... problems. The normal and shear stresses of the cohesive laws were obtained from data of the fracture resistance and the normal and tangential displacements ofthe cohesive zone. Delamination of a thin layer bonded to an elastic substrate close to corners and edges was also analysed. Results for the shape...... of the interface crack front and critical stress for steady-state delamination were obtained....

  13. Improved Structure and Fabrication of Large, High-Power KHPS Rotors - Final Scientific/Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Corren, Dean [Verdant Power, Inc.; Colby, Jonathan [Verdant Power, Inc.; Adonizio, Mary Ann [Verdant Power, Inc.

    2013-01-29

    Verdant Power, Inc, working in partnership with the National Renewable Energy Laboratory (NREL), Sandia National Laboratories (SNL), and the University of Minnesota St. Anthony Falls Laboratory (SAFL), among other partners, used evolving Computational Fluid Dynamics (CFD) and Finite Element Analysis (FEA) models and techniques to improve the structure and fabrication of large, high-power composite Kinetic Hydropower System (KHPS) rotor blades. The objectives of the project were to: design; analyze; develop for manufacture and fabricate; and thoroughly test, in the lab and at full scale in the water, the improved KHPS rotor blade.

  14. An unusual case of large prostatic utricle cyst: a case report

    International Nuclear Information System (INIS)

    Incedayi, M.; Sivrioglu, A.

    2012-01-01

    Full text: 16-year-old boy was referred to us for the management of recurrent urinary tract infection. The physical examination was revealed retrovesical mass. No other abnormality was found on physical examination. Ultrasound and magnetic resonance imaging showed a large retrovesical cyst. The patient underwent a complete resection through a suprapubic extraperitoneal approach. Histopathology revealed a 7cm long prostatic utricle cyst. In a patient with retrovesical cyst with clinical history of recurrent urinary tract infection, an enlarged prostatic utricle must be included in the differential diagnosis

  15. Laparoendoscopic Single-Site Surgery (LESS for a Large Ovarian Tumour: First Clinical Case Report

    Directory of Open Access Journals (Sweden)

    Yao Dong Chua

    2011-01-01

    Main Outcome Measure(s. Conversion to standard laparoscopic technique or laparotomy, estimated blood loss, operative time , extent of scarring, occurrence of intra- and perioperative surgical complications, technical adequacy, and clinical outcome. Result(s. No conversion to standard laparoscopic technique or laparotomy, and no intraoperative or postoperative complications were observed. Total operative time was 99 minutes. The patient was discharged home on postoperative day one. Conclusion(s. Laparoendoscopic single-site bilateral salpingo-oophorectomy of a large ovarian tumour is feasible with standard laparoscopic instruments. It is safe and effective, with good results in terms of excellent cosmesis and minimal postoperative pain.

  16. Case report: An interesting case of large colloid goiter with dyspnea

    Directory of Open Access Journals (Sweden)

    Jaya Prakasha Mayya

    2017-12-01

    Full Text Available Benign nodular goitre is one of the most common endocrine disorder, especially in countries like Nepal where iodine deficiency is endemic. Case History: A 59 years old female presented with large thyroid swelling. Investigations showed it to be colloid goiter compressing the airway. Left hemithyroidectomy was done. Post operative period was uneventful.Discussion: Management of thyroid nodules depends upon assessment of thyroid function, fine needle aspiration cytology and imaging. Surgery is the common method of treatment.   

  17. Hydrogen gains further momentum

    International Nuclear Information System (INIS)

    Anon.

    2017-01-01

    As first industrial production projects should become a reality in the next few years, hydrogen as a source of energy will find important applications with mobility, which momentum is rapid and irresistible. Next steps will be the (large capacity) storage of hydrogen associated to power-to-gas systems and the generalization of renewable energies. This document presents 5 articles, which themes are: Description and explanation of the process of hydrogen production; Presentation of the H2V project for the construction, in Normandy, of the first operational industrial hydrogen production plant using electric power 100 pc generated by renewable energies; The conversion of electric power from renewable energies through hydrogen storage and fuel cells for buildings applications (Sylfen project); The development of a reversible fuel cell at Mines-Paris Tech University, that will be adapted to the storage of renewable electric power; Hydrogen as a lever for the development of zero-emission vehicles, from trucks to cars and bicycles

  18. The Large Deployable Reflector (LDR) report of the Science Coordination Group

    Science.gov (United States)

    1986-01-01

    The Large Deployable Reflector (LDR) is a telescope designed to carry out high-angular resolution, high-sensitivity observations at far-infrared and submillimeter wavelengths. The scientific rationale for the LDR is discussed in light of the recent Infrared Astronomical Satellite (IRAS) and Kuiper Airborne Observatory (KAO) results and the several new ground-based observatories planned for the late 1980s. The importance of high sensitivity and high angular resolution observations from space in the submillimeter region is stressed. The scientific and technical problems of using the LDR in a light bucket mode at approx. less than 5 microns and in designing the LDR as an unfilled aperture with subarcsecond resolution are also discussed. The need for an aperture as large as 20 m is established, along with the requirements of beam-shape stability, spatial chopping, thermal control, and surface figure stability. The instrument complement required to cover the wavelength-spectral resolution region of interest to the LDR is defined.

  19. Capillary gas chromatographic analysis of nerve agents using large volume injections. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Deinum, T.; Nieuwenhuy, C.

    1994-11-01

    The procedure developed at TNO-Prins Maurits Laboratory (TNO-PML) for the verification of intact organophosphorus chemical warfare agents in water samples was improved. The last step in this procedure, the laborious and non-reproducible transfer of an ethyl acetate extract onto a Tenax-adsorption tube followed by thermal desorption of the Tenax-tube, was replaced by large volume injection of the extract onto a capillary gas chromatographic system. The parameters controlling the injection of a large volume of an extract (200 ul) were investigated and optimized. As ethyl acetate caused severe problems, potential new solvents were evaluated. With the improved procedure, the nerve agents sarin, tabun, soman, diisopropyl fluorophosphate (DFP) and VX could be determined in freshly prepared water samples at pg/ml (ppt) levels. The fate of the nerve agents under study in water at two pH`s (4.8 and 6) was investigated. For VX, the pH should be adjusted before extraction. Moreover, it is worthwhile to acidify water samples to diminish hydrolysis.

  20. Cross-flow turbines: progress report on physical and numerical model studies at large laboratory scale

    Science.gov (United States)

    Wosnik, Martin; Bachant, Peter

    2016-11-01

    Cross-flow turbines show potential in marine hydrokinetic (MHK) applications. A research focus is on accurately predicting device performance and wake evolution to improve turbine array layouts for maximizing overall power output, i.e., minimizing wake interference, or taking advantage of constructive wake interaction. Experiments were carried with large laboratory-scale cross-flow turbines D O (1 m) using a turbine test bed in a large cross-section tow tank, designed to achieve sufficiently high Reynolds numbers for the results to be Reynolds number independent with respect to turbine performance and wake statistics, such that they can be reliably extrapolated to full scale and used for model validation. Several turbines of varying solidity were employed, including the UNH Reference Vertical Axis Turbine (RVAT) and a 1:6 scale model of the DOE-Sandia Reference Model 2 (RM2) turbine. To improve parameterization in array simulations, an actuator line model (ALM) was developed to provide a computationally feasible method for simulating full turbine arrays inside Navier-Stokes models. Results are presented for the simulation of performance and wake dynamics of cross-flow turbines and compared with experiments and body-fitted mesh, blade-resolving CFD. Supported by NSF-CBET Grant 1150797, Sandia National Laboratories.

  1. [Malacoplakia of the large intestine, bladder and retroperitoneum: a case report].

    Science.gov (United States)

    Vattimo, A; Lupinacci, R A; Kerzner, A; da Silva, J H

    1990-01-01

    The authors present a case of malakoplakia, involving colon, rectum, bladder and retroperitoneum. This rare pathology, generally associated to Escherichia coli infections, result in a granulomatous disease, that can involve one or more organs. Nowadays, it is believed that the illness is due to a failure in the bactericide activity of the macrophage. This case, the first reported in our country, was treated clinically with ascorbic acid and trimethoprim-sulfamethoxazole, and is also unique in the world literature.

  2. Ordered and Unordered Top-K Range Reporting in Large Data Sets

    DEFF Research Database (Denmark)

    Afshani, Peyman; Brodal, Gerth Stølting; Zeh, Norbert

    2011-01-01

    We study the following problem: Given an array A storing N real numbers, preprocess it to allow fast reporting of the K smallest elements in the subarray A[i, j] in sorted order, for any triple (i, j,K) with 1 ≤ i ≤ j ≤ N and 1 ≤ K ≤ j − i + 1. We are interested in scenarios where the array A is ...

  3. Working group report on the required atomic database for neutral hydrogen beam penetration in large tokamaks

    International Nuclear Information System (INIS)

    Cox, M.; Boley, C.D.; Janev, R.K.

    1989-01-01

    This report discusses the required atomic database for the physical processes involved in the beam attenuation kinetics, when multistep processes are included, i.e., electron and proton impact processes, impurity-ion impact processes, radiative processes, as well as Lorentz field ionization. It also discusses the required accuracies of different parts of the data base in order to achieve the overall accuracy of about 10 percent that is required for the total beam stopping power cross section. 3 refs

  4. A large giant cell tumor of the larynx: case report and review of the literature.

    Science.gov (United States)

    Arndt, Andrew; LeBlanc, Rachelle; Spafford, Peter

    2017-04-04

    Giant cell tumors (GCTs) are typically found in the metaphyseal-epiphyseal area of long bones but can also occur in the head and neck region. GCT of the larynx is a rare entity with only 42 reported cases in the international literature. Furthermore, to the best of our knowledge this is the largest laryngeal GCT reported in the literature to date. GCT of the larynx can present with dysphonia, dyspnea, and/or dysphagia and should be considered in the differential diagnosis of a neck mass. This case report describes a giant cell tumor of the left thyroid cartilage in a 30-year-old man who initially presented with dysphonia and dysphagia. Computed tomography (CT) revealed a 5 × 5.7 cm mass centered on the left thyroid cartilage, which was further diagnosed by histopathology as giant cell tumour by open biopsy. The patient was counselled on treatment options and it was decided to proceed with a surgical approach. The patient consented to and successfully underwent a total laryngectomy (TL). Currently the patient has no evidence of disease at 13 months follow-up, has an optimal prosthetic voice, and is able to tolerate all textures of foods. GCTs of the larynx have a good prognosis and can be treated successfully through complete resection of the tumor, negating the need for adjunctive therapy such as radiation, chemo or denosumab therapy.

  5. Online Monitoring Technical Basis and Analysis Framework for Large Power Transformers; Interim Report for FY 2012

    Energy Technology Data Exchange (ETDEWEB)

    Nancy J. Lybeck; Vivek Agarwal; Binh T. Pham; Heather D. Medema; Kirk Fitzgerald

    2012-09-01

    The Light Water Reactor Sustainability program at Idaho National Laboratory (INL) is actively conducting research to develop and demonstrate online monitoring (OLM) capabilities for active components in existing Nuclear Power Plants. A pilot project is currently underway to apply OLM to Generator Step-Up Transformers (GSUs) and Emergency Diesel Generators (EDGs). INL and the Electric Power Research Institute (EPRI) are working jointly to implement the pilot project. The EPRI Fleet-Wide Prognostic and Health Management (FW-PHM) Software Suite will be used to implement monitoring in conjunction with utility partners: the Shearon Harris Nuclear Generating Station (owned by Duke Energy for GSUs, and Braidwood Generating Station (owned by Exelon Corporation) for EDGs. This report presents monitoring techniques, fault signatures, and diagnostic and prognostic models for GSUs. GSUs are main transformers that are directly connected to generators, stepping up the voltage from the generator output voltage to the highest transmission voltages for supplying electricity to the transmission grid. Technical experts from Shearon Harris are assisting INL and EPRI in identifying critical faults and defining fault signatures associated with each fault. The resulting diagnostic models will be implemented in the FW-PHM Software Suite and tested using data from Shearon-Harris. Parallel research on EDGs is being conducted, and will be reported in an interim report during the first quarter of fiscal year 2013.

  6. FEL gain optimisation and spontaneous radiation

    Energy Technology Data Exchange (ETDEWEB)

    Bali, L.M.; Srivastava, A.; Pandya, T.P. [Lucknow Univ. (India)] [and others

    1995-12-31

    Colson have evaluated FEL gains for small deviations from perfect electron beam injection, with radiation of the same polarisation as that of the wiggler fields. We find that for optimum gain the polarisation of the optical field should be the same as that of the spontaneous emission under these conditions. With a helical wiggler the axial oscillations resulting from small departures from perfect electron beam injection lead to injection dependent unequal amplitudes and phases of the spontaneous radiation in the two transverse directions. Viewed along the axis therefore the spontaneous emission is elliptically polarised. The azimuth of the ellipse varies with the difference of phase of the two transverse components of spontaneous emission but the eccentricity remains the same. With planar wigglers the spontaneous emission viewed in the axial direction is linearly polarised, again with an injection dependent azimuth. For optimum coherent gain of a radiation field its polarisation characteristics must be the same as those of the spontaneous radiation with both types of wiggler. Thus, with a helical wiggler and the data reported earlier, an increase of 10% in the FEL gain at the fundamental frequency and of 11% at the fifth harmonic has been calculated in the small gain per pass limit. Larger enhancements in gain may result from more favourable values of input parameters.

  7. Obtaining large-scale funding for empowerment-oriented qualitative research: a report from personal experience.

    Science.gov (United States)

    Padgett, Deborah K; Henwood, Benjamin F

    2009-06-01

    Obtaining funding for qualitative research remains a challenge despite greater openness to methodological pluralism. Such hurdles are presumably compounded when the proposed study employs empowerment theory, rendering it susceptible to charges of elevating ideology over rigor. This article draws on the authors' experience in securing large-scale funding for an empowerment-oriented qualitative study of homeless mentally ill adults. Lessons learned include the importance of weaving empowerment theory into the proposal's "argument," and infusing empowerment values into study protocols while simultaneously paying close attention to rigorous and transparent methods. Additional benefits accrue from having prior relationships with study sites and being willing to revise and resubmit proposals whenever possible. Though representing a fraction of all externally funded projects in the United States, qualitative research has tremendous untapped potential for success in this competitive arena-success that need not entail surrendering a commitment to empowerment values.

  8. Improved design for large wind turbine blades of fibre composites (Phase 3) - Summary report

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, B.F. (Risoe DTU, Materials Research Div., Roskilde (Denmark)); Branner, K. (Risoe DTU, Wind Energy Div., Roskilde (Denmark)); Lund, E. (Aalborg Univ., Dept. of Mechanical Engineering, Aalborg (Denmark)); Wedel-Heinen, J. (Vestas Wind System, Randers (Denmark)); Garm, J.H. (LM Glasfiber, Kolding (Denmark))

    2009-06-15

    An overview is given of the activities of the project 'Improved design for large wind turbine blades (Phase 3)', partially supported by the Danish Energy Agency under the Ministry of Climate and Energy through the EFP-grant no. 33031-0078. The project was focussed at the development of new design methods for wind turbine blades, so that uncertainties associated with damage and defects can be reduced. The following topics with respect to failure modes were covered: Buckling-driven delamination of load-carrying laminates, cracking along interfaces in material joints, implementation of cohesive laws in finite element programmes and hierarchical finite element models. Methods and major research results of the project are summarised. Some future goals for future research activities are briefly discussed. (author)

  9. Critical joints in large composite primary aircraft structures. Volume 2: Technology demonstration test report

    Science.gov (United States)

    Bunin, Bruce L.

    1985-01-01

    A program was conducted to develop the technology for critical structural joints in composite wing structure that meets all the design requirements of a 1990 commercial transport aircraft. The results of four large composite multirow bolted joint tests are presented. The tests were conducted to demonstrate the technology for critical joints in highly loaded composite structure and to verify the analytical methods that were developed throughout the program. The test consisted of a wing skin-stringer transition specimen representing a stringer runout and skin splice on the wing lower surface at the side of the fuselage attachment. All tests were static tension tests. The composite material was Toray T-300 fiber with Ciba-Geigy 914 resin in 10 mil tape form. The splice members were metallic, using combinations of aluminum and titanium. Discussions are given of the test article, instrumentation, test setup, test procedures, and test results for each of the four specimens. Some of the analytical predictions are also included.

  10. Report of preliminary investigations on the next-generation large-scale synchrotron radiation facility projects

    International Nuclear Information System (INIS)

    1990-01-01

    The Special Committee for Future Project of the Japanese Society for Synchrotron Radiation Research investigated the construction-projects of the large-scaled synchrotron radiation facilities which are presently in progress in Japan. As a result, the following both projects are considered the very valuable research-project which will carry the development of Japan's next-generation synchrotron radiation science: 1. the 8 GeV synchrotron radiation facilities (SPring-8) projected to be constructed by Japan Atomic Energy Research Institute and the Institute of Physical and Chemical Research under the sponsorship of Science Technology Agency at Harima Science Park City, Hyogo Pref., Japan. 2. The project to utilize the Tristan Main Ring (MR) of the National Laboratory for High Energy Physics as the radiation source. Both projects are unique in research theme and technological approach, and complemental each other. Therefore it has been concluded that both projects should be aided and ratified by the Society. (M.T.)

  11. Improved design of large wind turbine blades of fibre composites (Phase 2) - Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, B.F. [Risoe National Lab., Materials Research Dept., Roskilde (Denmark); Branner, K. [Risoe National Lab., Wind Energy Dept., Roskilde (Denmark); Stang, H. [Technical Univ. of Denmark, Dept. of Civil Engineering, Kgs. Lyngby (Denmark); Jensen, H.M. [Aalborg Univ., Dept. of Building Technology and Structural Engineering (Denmark); Lund, E. [Aalborg Univ., Inst. of Mechanical Enginering (Denmark); Jacobsen, T.K. [LM glasfiber A/S, Lunderskov (Denmark); Halling, K.M. [Vestas Wind Systems A/S, Ringkoebing (Denmark)

    2005-08-01

    The major results of Phase 2 of a project concerning the development of new design methods for wind turbine blades are summarised. Finite element models were used for studying the buckling behaviour of a box girder, tested to failure in Phase 1 of this project. The deformation behaviour of a box girder section subjected to transverse forces was investigated experimentally and by modelling. Buckling-driven delamination of planar specimens was studied on experimentally and by modelling. A novel approach was proposed for the determination of mixed mode cohesive laws for large-scale crack bridging problems. The normal and shear stresses of the cohesive laws were obtained from data of the fracture resistance and the normal and tangential displacements of the cohesive zone. Delamination of a thin layer bonded to an elastic substrate close to corners and edges was also analysed. Results for the shape of the interface crack front and critical stress for steady-state delamination were obtained. (au)

  12. Summary Report: The Shadow effect of large wind farms: measurements, data analysis and modelling

    DEFF Research Database (Denmark)

    Frandsen, Sten Tronæs; Barthelmie, Rebecca Jane; Rathmann, Ole

    It was the goal of the project – by means of data from the demonstration wind farms Horns Rev and Nysted, analyses of these data and modelling – to facilitate prediction of the power losses from a wind farm should a new wind farm be built upwind relative to the prevailing wind direction...... it may appropriate to build new wind farms rather close to the existing wind farms. A relevant question is therefore how far away new wind farms must be placed to avoid too large power losses. Measurements have been carried out for several years at the two sites, and databases have been prepared....... Thus, if different modelling efforts results in comparable results, the quality of the models will be tested outside the physical range where data are available. All considered the project participants find that the project has been immensely successful. The main achievements of the project are...

  13. Primary Cutaneous CD 30+ Anaplastic Large Cell Lymphoma. A Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Serra Valdés

    2014-03-01

    Full Text Available Primary cutaneous CD 30+ anaplastic large cell lymphoma is part of the spectrum of primary cutaneous CD30 + lymphoproliferative disorders, together with lymphomatoid papulosis. Its frequency is less than 0.5 x 100 000 inhabitants per year. It accounts for a very small proportion of non-Hodgkins lymphomas. The case of an 80-year-old female patient whose diagnosis was established in 2006 because of lesions on the face and neck is presented. The lesions continued to grow in an exaggerated fashion lately leading to deformity of her face. She was admitted due to neurological manifestations unrelated to the lesions. The presentation of this case is necessary because it requires performing differential diagnosis in clinical practice. Given its rarity, it is of interest to the medical community, especially trainees.

  14. [Sequencing by hybridization methods to generate large arrays of oligonucleotides]. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    The subject of this project is to address a pressing need for custom DNA microarrays (chips) which can be easily and at low cost formatted and revised for research. In this sense, the term custom means chips for which there is need for limited quantities (less than hundreds) of any particular chip design which contains a large number of different, users defined sequences. Of the three principal approaches to fabricate DNA microarrays, the two which have been commercialized (a and b below) are not particularly suited to research purposes because of the significant time and costs required, once a result is obtained, to utilize that result in the design of a new and better chip: (a) the photodeprotection scheme used by Affymetrix; and (b) the spotting of pre-synthesized oligos or c-DNA onto surfaces.

  15. Operability design review of prototype large breeder reactor (PLBR) designs. Final report, September 1981

    International Nuclear Information System (INIS)

    Beakes, J.H.; Ehman, J.R.; Jones, H.M.; Kinne, B.V.T.; Price, C.M.; Shores, S.P.; Welch, J.K.

    1981-09-01

    Prototype Large Breeder Reactor (PLBR) designs were reviewed by personnel with extensive power plant operations experience. Fourteen normal and off-normal events, such as startup, shutdown, refueling, reactor scram and loss of feedwater, were evaluated using an operational evaluation methodology which is designed to facilitate talk-through sessions on operational events. Human factors engineers participated in the review and assisted in developing and refining the review methodologies. Operating experience at breeder reactor facilities such as Experimental Breeder Reactor-II (EBR-II), Enrico Fermi Atomic Power Plant - Unit 1, and the Fast Flux Test Facility (FFTF) was gathered, analyzed, and used to determine whether lessons learned from operational experience had been incorporated into the PLBR designs. This eighteen month effort resulted in approximately one hundred specific recommendations for improving the operability of PLBR designs

  16. Aerodynamics of the Large-Volume, Flow-Through Detector System. Final report

    International Nuclear Information System (INIS)

    Reed, H.; Saric, W.; Laananen, D.; Martinez, C.; Carrillo, R.; Myers, J.; Clevenger, D.

    1996-03-01

    The Large-Volume Flow-Through Detector System (LVFTDS) was designed to monitor alpha radiation from Pu, U, and Am in mixed-waste incinerator offgases; however, it can be adapted to other important monitoring uses that span a number of potential markets, including site remediation, indoor air quality, radon testing, and mine shaft monitoring. Goal of this effort was to provide mechanical design information for installation of LVFTDS in an incinerator, with emphasis on ability to withstand the high temperatures and high flow rates expected. The work was successfully carried out in three stages: calculation of pressure drop through the system, materials testing to determine surrogate materials for wind-tunnel testing, and wind-tunnel testing of an actual configuration

  17. Clinical characteristics and treatment results of large cell lung cancer-62 case report

    International Nuclear Information System (INIS)

    Chen Dongfu; Ou Guangfei; Cheng Guiyu; Zhou Zongmei; Zhao Lujun; Wang Lvhua

    2004-01-01

    Objective: Objective To evaluate the clinical characteristics and treatment results of 60 patients with large cell lung cancer (LCLC). Methods: All sixty-two patients were diagnosed histopathologically with 5 in stage I, 13 in stage II, 30 in stage III and 14 in stage IV. Forty-five patients received primary surgical resection with 38 radical resection and 7 palliative resection. Non-surgical treatment was given to 17 patients. Mediastinum and ipsilateral hilum were treated to the total dose of 40-60 Gy in 4-6 weeks in 16 patients as postoperative adjuvant radiotherapy. For patients treated by radiation alone, the primary tumor bed, bilateral mediastinum and ipsilateral hilum were treated to the total dose of 36-70 Gy in 4-7 weeks. Results: The overall 1-, 3- and 5- year survival rates were 25.7%, 15.4% and 11.6%, respectively with the median survival time of 11.6 months. In the radically resected patients, the 1-, 3- and 5-year survival rates and the median survival time were 51.3%, 24.7%, 24.7% and 13 months, compared to those of 0%, 0%, 0% and 2 months in the palliatively resected group. In non-surgical treatment group, the 1-, 3- and 5-year survival rates and the median survival time were 41.2%, 21.2%, 7.0% and 11 months, respectively. Conclusions: The prognosis of large cell lung cancer is poor due to high distant metastasis rate. The long-term survival rate after radical resection is worse than the other lung cancers, but similar to the non-surgical treatment. (authors)

  18. MRI induced second-degree burn in a patient with extremely large uterine leiomyomas: A case report

    International Nuclear Information System (INIS)

    Lee, Chul Min; Kang, Bo Kyeong; Song, Soon Young; Koh, Byung Hee; Choi, Joong Sub; Lee, Won Moo

    2015-01-01

    Burns and thermal injuries related with magnetic resonance imaging (MRI) are rare. Previous literature indicates that medical devices with cable, cosmetics or tattoo are known as risk factors for burns and thermal injuries. However, there is no report of MRI-related burns in Korea. Herein, we reported a case of deep second degree burn after MRI in a 38-year-old female patient with multiple uterine leiomyomas including some that were large and degenerated. The large uterine leiomyoma-induced protruded anterior abdominal wall in direct contact with the body coil during MRI was suspected as the cause of injury, by retrospective analysis. Therefore, awareness of MRI related thermal injury is necessary to prevent this hazard, together with extreme care during MRI

  19. MRI induced second-degree burn in a patient with extremely large uterine leiomyomas: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chul Min; Kang, Bo Kyeong; Song, Soon Young; Koh, Byung Hee; Choi, Joong Sub; Lee, Won Moo [Hanyang University Medical Center, Hanyang University College of Medicine, Seoul (Korea, Republic of)

    2015-12-15

    Burns and thermal injuries related with magnetic resonance imaging (MRI) are rare. Previous literature indicates that medical devices with cable, cosmetics or tattoo are known as risk factors for burns and thermal injuries. However, there is no report of MRI-related burns in Korea. Herein, we reported a case of deep second degree burn after MRI in a 38-year-old female patient with multiple uterine leiomyomas including some that were large and degenerated. The large uterine leiomyoma-induced protruded anterior abdominal wall in direct contact with the body coil during MRI was suspected as the cause of injury, by retrospective analysis. Therefore, awareness of MRI related thermal injury is necessary to prevent this hazard, together with extreme care during MRI.

  20. Large mandibular central odontogenic fibroma documented over 20 years: A case report

    Directory of Open Access Journals (Sweden)

    Patrick Bandura

    Full Text Available Introduction: Central odontogenic fibroma (COF is a rare, benign, slow-growing intraosseous odontogenic tumor, and accounts for 0.1% of all odontogenic tumors. It is often confused with other entities, such as keratocysts, ameloblastomas, and odontogenic myxomas. Complete enucleation followed by curettage is the treatment of choice for COF to ensure the lowest possible chance of recurrence. Case presentation: We report the case of a young Caucasian woman with COF that went undiagnosed for several years despite repeated radiologic examinations. Finally, a massive tumor was surgically removed and the wound was curetted. The specimen was histologically confirmed to be a COF. The patient remains under regular follow-up, and thus far there have been no clinical or radiologic signs of recurrence. Discussion: This rare case of COF, which was documented over a period of 20 years, has helped us to describe the features of this tumor. It also confirms that adequate surgical treatment can lead to impressive bone regeneration in healthy individuals, as evident from the radiologic findings acquired before, during, and after enucleation of the COF in our patient. Our findings also confirm the view that COF has a favorable prognosis regardless of its final size. Conclusion: Early diagnosis is key to successful treatment of COF. The slow but steady increase in the size of a COF with no accompanying symptoms has not been reported previously. To our knowledge, this is the only documented case of a COF that has been under continuous radiologic observation for over 20 years. Keywords: Case report, Central odontogenic fibroma, Long-term, Bone deformation, Follow-up, Tumor enucleation

  1. Laparoscopic management of a large torted ovarian cyst in an adolescent virgin: a case report

    OpenAIRE

    Sabry, Mohamed; Mahmoud,Eman; Al-Hendy,Ayman

    2012-01-01

    Mohamed Sabry,1,2 Abdou S Ait Allah,1 Eman Roshdy,2,3 Ayman Al-Hendy21Department of Obstetrics and Gynecology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt; 2Department of Obstetrics and Gynecology, Center for Women’s Health Research, Meharry Medical College, Nashville, TN, USA; 3Department of Public Health and Community Medicine, Sohag Faculty of Medicine, Sohag University, Sohag, EgyptAbstract: We report a case of a torted mature cystic teratoma in a 23-year-old, sexu...

  2. Operational gain : measuring the capture of genetic gain ...

    African Journals Online (AJOL)

    The concept of operational gain is more than the weighted average of the genetic quality of planted hectares, and encompasses tree breeding efficiencies, propagation efficiencies, matching of species and genotype to site, plant use efficiency and early measures of stand density and growth. To test the operational gain ...

  3. Design and implementation of a near-miss reporting system at a large, academic pediatric anesthesia department.

    Science.gov (United States)

    Guffey, Patrick; Szolnoki, Judit; Caldwell, James; Polaner, David

    2011-07-01

    Current incident reporting systems encourage retrospective reporting of morbidity and mortality and have low participation rates. A near miss is an event that did not cause patient harm, but had the potential to. By tracking and analyzing near misses, systems improvements can be targeted appropriately, and future errors may be prevented. An electronic, web based, secure, anonymous reporting system for anesthesiologists was designed and instituted at The Children's Hospital, Denver. This portal was compared to an existing hospital incident reporting system. A total of 150 incidents were reported in the first 3 months of operation, compared to four entered in the same time period 1 year ago. An anesthesia-specific anonymous near-miss reporting system, which eases and facilitates data entry and can prospectively identify processes and practices that place patients at risk, was implemented at a large, academic, freestanding children's hospital. This resulted in a dramatic increase in reported events and provided data to target and drive quality and process improvement. © 2011 Blackwell Publishing Ltd.

  4. Capital Gains Taxation and House Price Fluctuations

    DEFF Research Database (Denmark)

    Fuest, Clemens; Nielsen, Søren Bo

    2004-01-01

    Recent years have seen large swings in house prices in many countries. Motivated by housing price variations, proposals for taxing capital gains on housing have repeatedly been put forth. The idea seems to be that such taxes would curb the redistribution occurring between those owning houses...... and those trying to get into the market for owner-occupied housing. Our paper shows that at least in simple settings, a tax on real capital gains on housing will only lead to even bigger price swings and will not be able to redistribute between people appearing on either side of the housing market.......Keywords: capital gains tax, housing market, price fluctuationsJEL-Classification: H23, H24, R 31.Addresses:...

  5. A Report on Simulation-Driven Reliability and Failure Analysis of Large-Scale Storage Systems

    Energy Technology Data Exchange (ETDEWEB)

    Wan, Lipeng [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wang, Feiyi [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Oral, H. Sarp [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Vazhkudai, Sudharshan S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Cao, Qing [Univ. of Tennessee, Knoxville, TN (United States)

    2014-11-01

    High-performance computing (HPC) storage systems provide data availability and reliability using various hardware and software fault tolerance techniques. Usually, reliability and availability are calculated at the subsystem or component level using limited metrics such as, mean time to failure (MTTF) or mean time to data loss (MTTDL). This often means settling on simple and disconnected failure models (such as exponential failure rate) to achieve tractable and close-formed solutions. However, such models have been shown to be insufficient in assessing end-to-end storage system reliability and availability. We propose a generic simulation framework aimed at analyzing the reliability and availability of storage systems at scale, and investigating what-if scenarios. The framework is designed for an end-to-end storage system, accommodating the various components and subsystems, their interconnections, failure patterns and propagation, and performs dependency analysis to capture a wide-range of failure cases. We evaluate the framework against a large-scale storage system that is in production and analyze its failure projections toward and beyond the end of lifecycle. We also examine the potential operational impact by studying how different types of components affect the overall system reliability and availability, and present the preliminary results

  6. Second-Generation Large Civil Tiltrotor 7- by 10-Foot Wind Tunnel Test Data Report

    Science.gov (United States)

    Theodore, Colin R.; Russell, Carl R.; Willink, Gina C.; Pete, Ashley E.; Adibi, Sierra A.; Ewert, Adam; Theuns, Lieselotte; Beierle, Connor

    2016-01-01

    An approximately 6-percent scale model of the NASA Second-Generation Large Civil Tiltrotor (LCTR2) Aircraft was tested in the U.S. Army 7- by 10-Foot Wind Tunnel at NASA Ames Research Center January 4 to April 19, 2012, and September 18 to November 1, 2013. The full model was tested, along with modified versions in order to determine the effects of the wing tip extensions and nacelles; the wing was also tested separately in the various configurations. In both cases, the wing and nacelles used were adopted from the U.S. Army High Efficiency Tilt Rotor (HETR) aircraft, in order to limit the cost of the experiment. The full airframe was tested in high-speed cruise and low-speed hover flight conditions, while the wing was tested only in cruise conditions, with Reynolds numbers ranging from 0 to 1.4 million. In all cases, the external scale system of the wind tunnel was used to collect data. Both models were mounted to the scale using two support struts attached underneath the wing; the full airframe model also used a third strut attached at the tail. The collected data provides insight into the performance of the preliminary design of the LCTR2 and will be used for computational fluid dynamics (CFD) validation and the development of flight dynamics simulation models.

  7. High-Luminosity Large Hadron Collider (HL-LHC) : Preliminary Design Report

    International Nuclear Information System (INIS)

    Apollinari, G.; Béjar Alonso, I.; Brüning, O.; Lamont, M.; Rossi, L.

    2015-01-01

    The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community of about 7,000 scientists working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase its luminosity (rate of collisions) by a factor of five beyond the original design value and the integrated luminosity (total collisions created) by a factor ten. The LHC is already a highly complex and exquisitely optimised machine so this upgrade must be carefully conceived and will require about ten years to implement. The new configuration, known as High Luminosity LHC (HL-LHC), will rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11-12 tesla superconducting magnets, compact superconducting cavities for beam rotation with ultra-precise phase control, new technology and physical processes for beam collimation and 300 metre-long high-power superconducting links with negligible energy dissipation. The present document describes the technologies and components that will be used to realise the project and is intended to serve as the basis for the detailed engineering design of HL-LHC.

  8. Large area silicon sheet by EFG. Fourth quarterly report, October 1-December 31, 1978

    Energy Technology Data Exchange (ETDEWEB)

    Wald, F.V.

    1979-03-01

    Crystal growth station no. 1 further explored displaced die concepts, along with some initial work on buckle characterization. Also, convective impurity redistribution was further studied. In particular, a side channel die was used to grow material doped with aluminum and compare the results at least semiquantitatively with computer calculations. The ribbons grown have not been characterized yet. In station no. 3A growth from single cartridges was continued to create a quality baseline to allow comparison of the results with those in the upcoming multiple run and to choose the most appropriate die design. Also fabrication and assembly work on the actual five ribbon furnace continued. On furnace 17 progress was made toward the development of the video optical system for edge position and meniscus height control. Also, in preparation for a detailed program, designed to explore the buckling problem, ribbon width ribon was then grown under stable conditions without a cold shoe, an achievement essential to finally arrive at quantitative correlations between growth conditions and buckle formation. The most significant result from the characterization program was a demonstration that the original runs with displaced dies were indeed reproducible, inasmuch as large area cells (7.5 x 7.5 cm/sup 2/) of approx. 9% efficiency could be fabricated again from run 18-103, a repeat of run no. 18-102 which had previously produced the best cells.

  9. High-Luminosity Large Hadron Collider (HL-LHC) : Preliminary Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Apollinari, G. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Béjar Alonso, I. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Brüning, O. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Lamont, M. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Rossi, L. [European Organization for Nuclear Research (CERN), Geneva (Switzerland)

    2015-12-17

    The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community of about 7,000 scientists working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase its luminosity (rate of collisions) by a factor of five beyond the original design value and the integrated luminosity (total collisions created) by a factor ten. The LHC is already a highly complex and exquisitely optimised machine so this upgrade must be carefully conceived and will require about ten years to implement. The new configuration, known as High Luminosity LHC (HL-LHC), will rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11-12 tesla superconducting magnets, compact superconducting cavities for beam rotation with ultra-precise phase control, new technology and physical processes for beam collimation and 300 metre-long high-power superconducting links with negligible energy dissipation. The present document describes the technologies and components that will be used to realise the project and is intended to serve as the basis for the detailed engineering design of HL-LHC.

  10. Large-scale hydrogen combustion experiments: Volume 2, Data plots: Final report

    International Nuclear Information System (INIS)

    Thompson, R.T.; Torok, R.C.; Randall, D.S.; Sullivan, J.S.; Thompson, L.B.; Haugh, J.J.

    1988-10-01

    Forty large-scale experiments to investigate the combustion behavior of hydrogen during postulated degraded core accidents were conducted in a 16 m (52 ft) diameter sphere. The performance of safety related equipment and cable also was examined. Combustion was initiated by thermal igniters in both premixed hydrogen air-steam atmospheres and during the continuous injection of hydrogen and steam. The effects of steam, igniter location, water sprays, fans and injection rates were studied. Measurements were made of gas concentrations, combustion pressures, temperatures and heat fluxes. Burn fractions and flame speeds also were determined. Near-infrared seeing cameras permitted direct observation of the hydrogen burns. Combustion pressures and temperatures in premixed atmospheres with hydrogen concentrations up to 13 vol% (steam saturated) were less than the theoretical maximum values. Multiple deflagrations were not encountered during continuous hydrogen injection with pre-activated igniters. Moderate pressure rises resulted from diffusion flames. These flames generally were found above the source. Combustion results have been compared to smaller scale experiments. Several safety related equipment items exhibited degraded performance after a number of tests. Most cable samples passed their electrical checks at the end of the test series. These experiments confirm the effectiveness of the deliberate ignition approach to controlling hydrogen. They also provide data for validating computer codes used to predict hydrogen combustion during degraded core accidents, and for assessing the performance of safety related equipment in such environments

  11. Preliminary Report On Combined Surgical- And Laser-Treatment Of Large Hemangiomas And Tattoos

    Science.gov (United States)

    Ginsbach, G.

    1981-05-01

    As most hemangiomas and tattoos require many sessions to be cured completely by argon-laser or conventional therapy I developed a new combined surgical and laser-therapy method for large hemangiomas and tattoos. This is a three step method. First: The skin lesion is treated by argon-laser with the point by point method, developed by ourself. Second: Under local or general anaesthesia a) the hemangioma is partially excised and undermined letting only the skin which is already treated by argon-laser-beams. Than the hemangioma is exstirpated in toto, the wound closed by running intradermal sutures and a pressure bandage applied, b) the tattoo is abraded as deep as possible, draped by lyofoam. Then a pressure bandage is applied. Third: The hemangioma as well as the tattoo are treated by argon-laser-beams after the operation. This method is safe and effective, gives good results, minimal scars in the case of hemangiomas and tattoos. In this paper the method is described and some cases are illustrated by pre- and postoperational photographs.

  12. High-Luminosity Large Hadron Collider (HL-LHC) Technical Design Report V. 0.1

    CERN Document Server

    Béjar Alonso I.; Brüning O.; Fessia P.; Lamont M.; Rossi L.; Tavian L.

    2017-01-01

    The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a newenergy frontier for exploration in 2010, it has gathered a global user community of about 7,000 scientists work-ing in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. Tosustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase itsinstantaneous luminosity (rate of collisions) by a factor of five beyond the original design value and the integratedluminosity (total collisions created) by a factor ten. The LHC is already a highly complex and exquisitely opti-mised machine so this upgrade must be carefully conceived and will require about ten years to implement. Thenew configuration, known as High Luminosity LHC (HL-LHC), relies on a number of key innovations that pushaccelerator technology beyond its present limits. Among these are cutting-edge 11-12 tesla superconducting mag-nets, compact superconduc...

  13. High-Luminosity Large Hadron Collider (HL-LHC) Preliminary Design Report

    CERN Document Server

    Apollinari, G; Béjar Alonso, I; Brüning, O; Lamont, M; Rossi, L

    2015-01-01

    The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community of about 7,000 scientists working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase its luminosity (rate of collisions) by a factor of five beyond the original design value and the integrated luminosity (total collisions created) by a factor ten. The LHC is already a highly complex and exquisitely optimised machine so this upgrade must be carefully conceived and will require about ten years to implement. The new configuration, known as High Luminosity LHC (HL-LHC), will rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11-12 tesla superconducting magnets, compact superconducting cav...

  14. IMPER: Characterization of the wind field over a large wind turbine rotor - final report; Improved performance

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt Paulsen, U.; Wagner, R.

    2012-01-15

    A modern wind turbine rotor with a contemporary rotor size would easily with the tips penetrate the air between 116 m and 30 m and herby experience effects of different wind. With current rules on power performance measurements such as IEC 61400-121 the reference wind speed is measured at hub height, an oversimplification of the wind energy power over the rotor disk area is carried out. The project comprised a number of innovative and coordinated measurements on a full scale turbine with remote sensing technology and simulations on a 500 kW wind turbine for the effects of wind field characterization. The objective with the present report is to give a short overview of the different experiments carried out and results obtained within the final phase of this project. (Author)

  15. CRADA/NFE-15-05779 Report: Fabrication of Large Area Printable Composite Magnets

    Energy Technology Data Exchange (ETDEWEB)

    Paranthaman, M Parans [ORNL

    2016-09-29

    The technical objective of this technical collaboration phase I proposal was to fabricate large area NdFeB composite magnets at the Oak Ridge National Laboratory Manufacturing Demonstration Facility (ORNL MDF). The goal was to distribute domestically produced isotropic and highly anisotropic high energy density magnetic particles throughout the composite structure in order to enable site specific placement of magnetic phases and minimize the generated waste associated with permanent magnet manufacturing. Big area additive manufacturing (BAAM) and magnet composite fabrication methods were used in this study. BAAM was used to fabricate 65 vol % isotropic MQP NdFeB magnets in nylon polymer matrix. BAAM magnet cylinder was sliced to two magnetic arc-shaped braces. The density of the small BAAM magnet pieces reached 4.1 g/cm3, and the room temperature magnetic properties are: Intrinsic coercivity Hci = 8.8 kOe, Remanence Br = 4.2 kG, and energy product (BH)max = 3.7 MGOe. Also, 1.5” x 1.5” composite magnets with anisotropic MQA NdFeB magnet in a resin were also fabricated under magnetic field. The unaligned sample had a density of 3.75 g/cm3. However, aligned sample possessed a density of 4.27 g/cm3. The magnetic properties didn’t degrade during this process. This study provides a pathway for preparing composite magnets for various magnetic applications.

  16. 200 city survey. JEMS 2001 annual report on EMS operational & clinical trends in large, urban areas.

    Science.gov (United States)

    Cady, Geoff

    2002-02-01

    This year's survey offered examples of evolving partnerships between the public and EMS providers with a growing number of systems implementing PAD programs. The apparent influence of a communication center's managing agency on prioritization strategies is concerning. However, further study is needed. EMS managers must pay careful attention to comm center practices and technology to ensure their ability to support response prioritization and the efficient management of EMS resources. The small reduction in the use of hot response (lights and siren) to every request for service is disappointing in light of medical literature and position statements that condemn this practice. Resource response can be safely prioritized using today's EMD protocol systems. Prioritization and changing response [figure: see text] time requirements to address impending revenue and service demand changes will require additional standardization of methodologies and reporting of response times to relate this measure to other system performance indicators (e.g., patient morbidity/mortality, cost, customer satisfaction, etc.). The future presents a difficult road for system administrators. However, the adoption of a growing number of information-management tools and changes in procedures and dispatch processes offer potential solutions. The increased use of hand-held computers or personal digital assistant (PDAs) to gather and provide information and the almost universal use of CAD will aid providers in performing the research necessary to change response time performance requirements, improving EMS system efficiency. Use of this technology will also likely improve patient care and reimbursement through more timely and accurate reporting and analysis. The medical director's role will be critical to ensuring potential changes don't compromise patient care. Obtaining a better understanding of how much time can safely elapse between the time of the 9-1-1 call and when patient-care activities

  17. Paul Scherrer Institut annual report 1995. Annex IIIA: Solid state research at large facilities

    International Nuclear Information System (INIS)

    Baltensperger, U.; Lorenzen, R.

    1996-01-01

    The PSI research department IIIA is engaged in the final push to establish two research facilities: - the spallation neutron source (SINQ) and its instrumentation, - a positron source with high beam quality. The latter is essentially completed and ready for commissioning. The laboratory for Ion Beam Physics again served to many institutions with their accelerator mass spectroscopy by analyzing about 4000 samples. The new gas-jet facility and the neutron activation system at SINQ will be most important for the work of the laboratory of Radio- and Environmental Chemistry. Hence considerable effort has been put into the conception of this insertion device at the spallation source. Like in the previous year the laboratory of Neutron scattering was still relying on the access to neutron sources elsewhere than PSI. Regular access was available at ILL at a powder diffractometer and a triple axis spectrometer, upgraded and operated by PSI. Hence, besides the work for the instrumentation of SINQ, we had the opportunity to keep the scientific activities alive. Results of the laboratory of Astrophysics: one of the Radiation Environmental Monitors (REM) has now been in orbit for more than one year aboard the UK-satellite STRV-1B. The other monitor on a low circular orbit of a MIR-station also reports its results since about one year. (author) figs., tabs., refs

  18. Paul Scherrer Institut annual report 1995. Annex IIIA: Solid state research at large facilities

    Energy Technology Data Exchange (ETDEWEB)

    Baltensperger, U.; Lorenzen, R. [eds.

    1996-10-01

    The PSI research department IIIA is engaged in the final push to establish two research facilities: - the spallation neutron source (SINQ) and its instrumentation, - a positron source with high beam quality. The latter is essentially completed and ready for commissioning. The laboratory for Ion Beam Physics again served to many institutions with their accelerator mass spectroscopy by analyzing about 4000 samples. The new gas-jet facility and the neutron activation system at SINQ will be most important for the work of the laboratory of Radio- and Environmental Chemistry. Hence considerable effort has been put into the conception of this insertion device at the spallation source. Like in the previous year the laboratory of Neutron scattering was still relying on the access to neutron sources elsewhere than PSI. Regular access was available at ILL at a powder diffractometer and a triple axis spectrometer, upgraded and operated by PSI. Hence, besides the work for the instrumentation of SINQ, we had the opportunity to keep the scientific activities alive. Results of the laboratory of Astrophysics: one of the Radiation Environmental Monitors (REM) has now been in orbit for more than one year aboard the UK-satellite STRV-1B. The other monitor on a low circular orbit of a MIR-station also reports its results since about one year. (author) figs., tabs., refs.

  19. The Pyrolysis Kinetics of Large Biomass Particles. Summary Report 2000-2002

    Energy Technology Data Exchange (ETDEWEB)

    Davidsson, Kent O.; Hagstroem, Magnus; Stojkova, Borka; Andersson, Patrik U.; Loenn, Benny; Pettersson, Jan B.C. [Goeteborg Univ. (Sweden). Dept. of Chemistry

    2002-12-01

    This report describes the progress made during the first two years of the present project. The aim of the project is to provide experimental data on single biomass particle pyrolysis that have an applied as well as a fundamental bearing. Transport phenomena and kinetics on the single particle level are characterized, including heat and mass transport processes. New experimental techniques and methods are applied and developed within the project. A single-particle reactor has been developed for the investigations, and several detection techniques including fast thermogravimetric analysis, molecular beam mass spectrometry (MBMS), laser spectroscopy, video recording and pyrometry are applied. The experimental data are used to develop robust models for pyrolysis and gasification, which are essential components in the design of gasification and combustion reactors. The project is a cooperation between the Department of Chemistry, Physical Chemistry, Goeteborg University and the Department of Chemical Engineering and Technology/Chemical Technology, KTH, and personnel from both universities are directly involved in the work. Both groups are members of the CeCoST program. The project also involves cooperation with Department of Energy Conversion, CTH, and Combustion Physics, LTH. This cooperation has during the present project period involved laser spectroscopic studies of biomass pyrolysis. During the coming project period, we also intend to include direct comparisons between pyrolysis models developed by the different groups.

  20. Effect of classic back massage on spinal pain in a woman with large breasts - case report

    Directory of Open Access Journals (Sweden)

    Natalia Zielińska

    2017-07-01

    Full Text Available Introduction. The most common ailment of the motion system is spinal pain. For one of the main reasons, it consider a sedentary lifestyle that weakens the musculo-skeletal system, obesity that increases spine load, sleep disorders resulting from unsettled positions during rest or sleep, and chronic stress. The use of massage can reduce the painful pain of the spine, by loosening the excessively tight spine muscles, the articular joints of the joints and the relaxation of the body. Objective. An assessment of the effect of classical spine massage on spinal pain in a woman with large breasts. Material and methods. 10 massage treatments of the classical ridge using olive oil were performed. Sessions took place 2-3 times a week after 30-50 minutes. Before and after intervention were measured: linear measurements of upper and lower limbs; Measurement of the first and short long and short for the upper and lower limbs for the upper and lower extremities; Measurement of the range of mobility of individual segments of the spine; Measurement of muscle strength of the cervical, thoracic and lumbar musculature of the upper limbs; Assessment of deviation from the symmetry of body posture. Also tested was the Cross Stroke Challenge, finger-to-floor test, lumbar vertebrae overtaxis test, Laseque test, Scherer test and Gilett test. Results. The difference in the range of motion, ie the flexion of the thorax and lumbar spine and the finger-to-floor examination, was statistically significantly different. After intervention the silhouette of the body was positioned closer to the vertical axis. The Laseque test for both lower limbs turned out to be negative. The difference in linear and limb length measurements and the Schober test was not statistically significant. The test of cross-provocation, the overtaking test for the lumbar spine movement and the Gillet test did not show deviations before or after intervention. Conclusions. Therapeutic massage of the

  1. High Gain Advanced GPS Receiver

    National Research Council Canada - National Science Library

    Brown, Alison; Zhang, Gengsheng

    2006-01-01

    NAVSYS High Gain Advanced GPS Receiver (HAGR) uses a digital beam-steering antenna array to enable up to eight GPS satellites to be tracked, each with up to 10 dBi of additional antenna gain over a conventional receiver solution...

  2. Performance Prediction for Large-Scale Nuclear Waste Repositories: Final Report

    International Nuclear Information System (INIS)

    Glassley, W E; Nitao, J J; Grant, W; Boulos, T N; Gokoffski, M O; Johnson, J W; Kercher, J R; Levatin, J A; Steefel, C I

    2001-01-01

    The goal of this project was development of a software package capable of utilizing terascale computational platforms for solving subsurface flow and transport problems important for disposal of high level nuclear waste materials, as well as for DOE-complex clean-up and stewardship efforts. We sought to develop a tool that would diminish reliance on abstracted models, and realistically represent the coupling between subsurface fluid flow, thermal effects and chemical reactions that both modify the physical framework of the rock materials and which change the rock mineralogy and chemistry of the migrating fluid. Providing such a capability would enhance realism in models and increase confidence in long-term predictions of performance. Achieving this goal also allows more cost-effective design and execution of monitoring programs needed to evaluate model results. This goal was successfully accomplished through the development of a new simulation tool (NUFT-C). This capability allows high resolution modeling of complex coupled thermal-hydrological-geochemical processes in the saturated and unsaturated zones of the Earth's crust. The code allows consideration of virtually an unlimited number of chemical species and minerals in a multi-phase, non-isothermal environment. Because the code is constructed to utilize the computational power of the tera-scale IBM ASCI computers, simulations that encompass large rock volumes and complex chemical systems can now be done without sacrificing spatial or temporal resolution. The code is capable of doing one-, two-, and three-dimensional simulations, allowing unprecedented evaluation of the evolution of rock properties and mineralogical and chemical change as a function of time. The code has been validated by comparing results of simulations to laboratory-scale experiments, other benchmark codes, field scale experiments, and observations in natural systems. The results of these exercises demonstrate that the physics and chemistry

  3. Leiomiossarcoma do intestino grosso: relato de um caso Large bowel leiomyosarcoma: a case report

    Directory of Open Access Journals (Sweden)

    Simone Gonçalves Lopes

    2001-04-01

    Full Text Available Os autores relatam um caso de leiomiossarcoma de cólon ascendente acometendo um paciente do sexo masculino, de 49 anos de idade. O paciente iniciou o quadro com anemia e massa abdominal, e a evolução dos sintomas até o diagnóstico final foi de nove meses. Na radiografia simples do abdome havia presença de coleção aérea localizada no hipocôndrio direito, fora da topografia de alças; no clister opaco com duplo contraste foi demonstrado deslocamento inferior da flexura hepática e divertículos. A ultra-sonografia abdominal mostrou lesão expansiva heterogênea, com gás no seu interior, de localização sub-hepática. A tomografia computadorizada do abdome revelou massa escavada com nível líquido, sub-hepática, que não se impregnou pelo meio de contraste. Foi realizada hemicolectomia direita com ileocoloanastomose, e o diagnóstico histopatológico foi de leiomiossarcoma de cólon ascendente.The authors report a case of a 49-year-old male patient with leiomyosarcoma of the ascending colon. The patient presented with anemia and an abdominal mass, and the symptoms progressed until a final diagnosis was made nine months later. A plain abdominal x-ray showed the presence of gas outside the bowel, in the right hypochondrium. The double contrast barium enema showed a sublevel displacement of the hepatic flexure and diverticula. An abdominal ultrasound revealed a heterogeneous expansive lesion below the liver containing gas, and a computed tomography of the abdomen revealed an excavated mass below the liver containing liquid, that was not filled in by contrast medium. The patient was submitted to a right hemicolectomy with ileocoloanastomosis and the histopathological analysis of the excised material revealed a leiomyosarcoma of the ascending colon.

  4. Intracapsular and para-articular chondroma adjacent to large joints: report of three cases and review of the literature

    International Nuclear Information System (INIS)

    Gonzalez-Lois, C.; Garcia-de-la-Torre, J.P.; SantosBriz-Terron, A.; Martinez-Tello, F.J.; Vila, J.; Manrique-Chico, J.

    2001-01-01

    Para-articular chondroma is a rare tumor that has been reported in only 30 cases adjacent to large joints in the Anglo-Saxon literature. We report three new cases of this entity, describe its clinical, radiological and pathological features, and review the previous literature. Para-articular chondromas have an insidious clinical presentation and on radiographs show a large soft tissue mass with variable ossification. They appear as a lobulated mass of hyaline cartilage with variable endochondral ossification in the central area. These rare benign tumors arise from the capsule or the para-articular connective tissue of a large joint (mainly the knee), which suffers cartilaginous metaplasia and subsequent ossification. Cases 1 and 2 of this presentation fit all the features described previously. Case 3 has identical clinical features but differs from the former two cases in its microscopic appearance, being composed almost entirely of fibrocartilage and myxoid areas within the fibroadipose tissue of the joint instead of mature trabecular bone surrounded by hyaline cartilage. To the best of our knowledge this is the first description of this histological variant of para-articular chondroma. (orig.)

  5. Intracapsular and para-articular chondroma adjacent to large joints: report of three cases and review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez-Lois, C.; Garcia-de-la-Torre, J.P.; SantosBriz-Terron, A.; Martinez-Tello, F.J. [Dept. of Pathology, University Hospital ' ' Doce de Octubre' ' , Madrid (Spain); Vila, J. [Dept. of Orthopedics and Traumatology, University Hospital ' ' Doce de Octubre' ' , Madrid (Spain); Manrique-Chico, J. [Dept. of Radiology, University Hospital ' ' Doce de Octubre' ' , Madrid (Spain)

    2001-12-01

    Para-articular chondroma is a rare tumor that has been reported in only 30 cases adjacent to large joints in the Anglo-Saxon literature. We report three new cases of this entity, describe its clinical, radiological and pathological features, and review the previous literature. Para-articular chondromas have an insidious clinical presentation and on radiographs show a large soft tissue mass with variable ossification. They appear as a lobulated mass of hyaline cartilage with variable endochondral ossification in the central area. These rare benign tumors arise from the capsule or the para-articular connective tissue of a large joint (mainly the knee), which suffers cartilaginous metaplasia and subsequent ossification. Cases 1 and 2 of this presentation fit all the features described previously. Case 3 has identical clinical features but differs from the former two cases in its microscopic appearance, being composed almost entirely of fibrocartilage and myxoid areas within the fibroadipose tissue of the joint instead of mature trabecular bone surrounded by hyaline cartilage. To the best of our knowledge this is the first description of this histological variant of para-articular chondroma. (orig.)

  6. Energy gains from lattice-enabled nuclear reactions

    International Nuclear Information System (INIS)

    Nagel, David J.

    2015-01-01

    The energy gain of a system is defined as the ratio of its output energy divided by the energy provided to operate the system. Most familiar systems have energy gains less than one due to various inefficiencies. By contrast, lattice-enabled nuclear reactions (LENR) offer high energy gains. Theoretical values in excess of 1000 are possible. Energy gains over 100 have already been reported. But, they have not yet been sustained for commercially significant durations. This article summarizes the current status of LENR energy gains. (author)

  7. An Improved Adaptive-Torque-Gain MPPT Control for Direct-Driven PMSG Wind Turbines Considering Wind Farm Turbulences

    Directory of Open Access Journals (Sweden)

    Xiaolian Zhang

    2016-11-01

    Full Text Available Maximum power point tracking (MPPT plays an important role in increasing the efficiency of a wind energy conversion system (WECS. In this paper, three conventional MPPT methods are reviewed: power signal feedback (PSF control, decreased torque gain (DTG control, and adaptive torque gain (ATG control, and their potential challenges are investigated. It is found out that the conventional MPPT method ignores the effect of wind turbine inertia and wind speed fluctuations, which lowers WECS efficiency. Accordingly, an improved adaptive torque gain (IATG method is proposed, which customizes adaptive torque gains and enhances MPPT performances. Specifically, the IATG control considers wind farm turbulences and works out the relationship between the optimal torque gains and the wind speed characteristics, which has not been reported in the literature. The IATG control is promising, especially under the ongoing trend of building wind farms with large-scale wind turbines and at low and medium wind speed sites.

  8. Self-reported sleep and nap habits and risk of mortality in a large cohort of older women.

    Science.gov (United States)

    Stone, Katie L; Ewing, Susan K; Ancoli-Israel, Sonia; Ensrud, Kristine E; Redline, Susan; Bauer, Douglas C; Cauley, Jane A; Hillier, Teresa A; Cummings, Steven R

    2009-04-01

    To determine the association between self-reported sleep and nap habits and mortality in a large cohort of older women. Study of Osteoporotic Fractures prospective cohort study. Four communities within the United States. Eight thousand one hundred one Caucasian women aged 69 and older (mean age 77.0). Sleep and nap habits were assessed using a questionnaire at the fourth clinic visit (1993/94). Deaths during 7 years of follow-up were confirmed with death certificates. Underlying cause of death was assigned according to the International Classification of Diseases, Ninth Revision, Clinical Modification. In multivariate models, women who reported napping daily were 44% more likely to die from any cause (95% confidence interval (CI)=1.23-1.67), 58% more likely to die from cardiovascular causes (95% CI=1.25-2.00), and 59% more likely to die from noncardiovascular noncancer causes (95% CI=1.24-2.03) than women who did not nap daily. This relationship remained significant in relatively healthy women (those who reported no comorbidities). Women who slept 9 to 10 hours per 24 hours were at greater risk of death from cardiovascular and other (noncardiovascular, noncancer) causes than those who reported sleeping 8 to 9 hours. Older women who reported napping daily or sleeping at least 9 hours per 24 hours are at greater risk of death from all causes except cancer. Future research could determine whether specific sleep disorders contribute to these relationships.

  9. Intravascular Large B-Cell Lymphoma Presenting with Diffuse Gallbladder Wall Thickening: A Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Sayf Al-Katib

    2018-01-01

    Full Text Available Intravascular large B-cell lymphoma is a rare subtype of extranodal diffuse B-cell lymphoma characterized by proliferation of neoplastic cells within the lumen of small and medium sized vessels. Clinical and imaging findings are nebulous as the intravascular subtype of lymphoma can involve a multitude of organs. Involvement of the gallbladder is extremely uncommon, and imaging findings can be easily confused for more prevalent pathologies. We report a case of intravascular large B-cell lymphoma in an 83-year-old male and review clinical presentation and imaging findings on CT, ultrasound, hepatobiliary iminodiacetic acid (HIDA scan, and MRI. It is important for the radiologist to know about this disease as the imaging findings are atypical of other types of lymphoma, and this may lead to a delay in diagnosis and treatment.

  10. An Unusual Case of a Large Hematorrachis Associated with Multi-Level Osteoporotic Vertebral Compression Fractures; a Case Report

    Directory of Open Access Journals (Sweden)

    T.V. Ravi Kumar

    2015-04-01

    Full Text Available Spinal epidural haemorrhage may present as back pain associated with radicular symptoms and can be a catastrophic clinical scenario with progression to paraplegia or even sudden death. Being a rare entity, it needs a high index ofclinical suspicion to diagnose it. Fractures have been documented as a cause of hematorrachis but such hematomas only extend to one or two vertebral segments. Large epidural hematomas are usually associated with conditions like bleeding diathesis, arterio-venous malformations, plasma cell myeloma, and non-Hodgkin’s lymphoma. Surgical management with immediate evacuation of the hematoma is the usual line of management in patients with neurological deficits. Though rare, monitored and careful conservative management can lead to recovery of neurological symptoms and resolution of the hematoma. We report a case of a very large post traumatic epidural hematorrchis extending to 11 vertebral segments from D3 to L1 vertebral bodies, who had a gradual spontaneous recovery.

  11. Gastric diffuse large B cell lymphoma presenting as para neoplastic cerebellar degeneration: Case report and review of literature

    International Nuclear Information System (INIS)

    Lakshmaiah, K.C.; Viveka, B.K.; Kumar, N.A.; Saini, M.L.; Sinha, S.; Saini, K.S.

    2013-01-01

    Para neoplastic cerebellar degeneration (PCD) is a type of para neoplastic neurological disorder (PND) that is associated with many solid tumors, Hodgkins lymphoma (HL) and very rarely with non-Hodgkin lymphoma (NHL). We report a case of PCD associated with gastric diffuse large B-cell lymphoma (DLBCL) in a patient who presented with acute onset of giddiness and double vision and had complete remission of the gastric lesion and marked improvement of cerebellar syndrome with rituximab-based combination chemotherapy. A brief review of the literature is also presented.

  12. Large subgaleal hematoma producing turban head in 10 year boy with cerebral palsy: rare case report with review of literature

    Directory of Open Access Journals (Sweden)

    Tripathi Praveen Kumar

    2016-12-01

    Full Text Available Subgaleal hematomas (SGHs are not uncommon. Because the subgaleal space has no anatomical boundaries, SGHs usually involve a large space and are typically limited to the parietal region. Cases of SGHs involving whole of head are relatively rare. In this study we report a rare case of massive enlargement of head after SGH causing severe pain and giving an appearance of turban. A 10 year old, male patient with cerebral palsy presented with progressive enlargement of head attaining a size of turban due to habitual head banging and self-punching overhead. SGH drainage and hematoma aspiration were performed and the patient’s head size was restored.

  13. Antenatal sonographic appearance of a large orbital encephalocele: a case report and differential diagnosis of orbital cystic mass.

    Science.gov (United States)

    Ahmed, Ahmed; Noureldin, Rehab; Gendy, Mohamed; Sakr, Sharif; Abdel Naby, Mahmoud

    2013-06-01

    Orbital meningoceles and encephaloceles are rare extracranial extensions of the brain and meninges with or without direct communication between the central nervous system and the abnormal mass. We reported a rare case of large fetal orbital encephalocele; the diagnosis was suspected initially by prenatal ultrasound and confirmed by postnatal MRI and CT scans. The differential diagnosis of an intrauterine fetal cystic orbital mass includes orbital teratoma, epidermoid inclusion cysts, hemangioma or lymphangioma, congenital cystic eye, dacryocystocele, and orbital cephalocele. Copyright © 2012 Wiley Periodicals, Inc.

  14. Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report.

    Science.gov (United States)

    Tuhan, Hale; Abaci, Ayhan; Sarsık, Banu; Öztürk, Tülay; Olguner, Mustafa; Catli, Gonul; Anik, Ahmet; Olgun, Nur; Bober, Ece

    2017-08-01

    Intratubular large cell hyalinizing Sertoli cell neoplasia (ITLCHSCN) resulting from Sertoli cells of the testis are mainly reported in young adults and these are rarely seen in childhood. The most common presenting symptoms of the patients diagnosed with ITLCHSCN are gynecomastia, enlargement in the testicles, increase in growth velocity, and advanced bone age. Symptoms are basically resulting from increased aromatase enzyme activity in Sertoli cells. In this case report, an eight-and-a-half-year-old case presenting with complaint of bilateral gynecomastia since two years, showing no endocrine abnormality in laboratory during two years of follow-up, determined to have progression in bilateral gynecomastia, increase in testicular volumes, advanced bone age, increase in growth velocity in the clinical follow-up, and diagnosed with ITLCHSCN after testis biopsy was presented.

  15. Diabetes insipidus due to herpes encephalitis in a patient with diffuse large cell lymphoma. A case report.

    Science.gov (United States)

    Scheinpflug, K; Schalk, E; Reschke, K; Franke, A; Mohren, M

    2006-01-01

    The major causes of central diabetes insipidus are neoplastic or infiltrative lesions of the hypothalamus or pituitary, severe head injuries and pituitary or hypothalamic surgery. Central diabetes insipidus caused by viral infections has been rarely reported in immunosuppressed patients, such as those with acquired immunodeficiency syndrome or Cushing's syndrome. We report the case of a 48-year-old woman suffering from diffuse large cell lymphoma, who developed hypotonic polyuria, hypernatriaemia and somnolence after the first course of chemotherapy with CHOEP and rituximab. Diabetes insipidus was diagnosed by low urine osmolarity and an undetectable vasopressin concentration. MRI revealed no pituitary abnormalities but encephalitis, and lumbar punction confirmed herpes zoster infection. To the best of our knowledge this is the first description of central diabetes insipidus in a lymphoma patient caused by an opportunistic CNS-infection.

  16. Health problems awareness during travel among faculty members of a large university in Latin America: preliminary report

    Directory of Open Access Journals (Sweden)

    Ana Cristina Nakamura Tome

    2013-02-01

    Full Text Available Health safety during trips is based on previous counseling, vaccination and prevention of infections, previous diseases or specific problems related to the destination. Our aim was to assess two aspects, incidence of health problems related to travel and the traveler's awareness of health safety. To this end we phone-interviewed faculty members of a large public University, randomly selected from humanities, engineering and health schools. Out of 520 attempts, we were able to contact 67 (12.9% and 46 (68.6% agreed to participate in the study. There was a large male proportion (37/44, 84.1%, mature adults mostly in their forties and fifties (32/44, 72.7%, all of them with higher education, as you would expect of faculty members. Most described themselves as being sedentary or as taking occasional exercise, with only 15.9% (7/44 taking regular exercise. Preexisting diseases were reported by 15 travelers. Most trips lasted usually one week or less. Duration of the travel was related to the destination, with (12h or longer trips being taken by 68.2% (30/44 of travelers, and the others taking shorter (3h domestic trips. Most travelling was made by air (41/44 and only 31.8% (14/44 of the trips were motivated by leisure. Field research trips were not reported. Specific health counseling previous to travel was reported only by two (4.5%. Twenty seven of them (61.4% reported updated immunization, but 11/30 reported unchecked immunizations. 30% (9/30 reported travel without any health insurance coverage. As a whole group, 6 (13.6% travelers reported at least one health problem attributed to the trip. All of them were males travelling abroad. Five presented respiratory infections, such as influenza and common cold, one neurological, one orthopedic, one social and one hypertension. There were no gender differences regarding age groups, destination, type of transport, previous health counseling, leisure travel motivation or pre-existing diseases

  17. Health problems awareness during travel among faculty members of a large university in Latin America: preliminary report.

    Science.gov (United States)

    Tome, Ana Cristina Nakamura; Canello, Thaís Brandi; Luna, Expedito José de Albuquerque; Andrade Junior, Heitor Franco de

    2013-01-01

    Health safety during trips is based on previous counseling, vaccination and prevention of infections, previous diseases or specific problems related to the destination. Our aim was to assess two aspects, incidence of health problems related to travel and the traveler's awareness of health safety. To this end we phone-interviewed faculty members of a large public University, randomly selected from humanities, engineering and health schools. Out of 520 attempts, we were able to contact 67 (12.9%) and 46 (68.6%) agreed to participate in the study. There was a large male proportion (37/44, 84.1%), mature adults mostly in their forties and fifties (32/44, 72.7%), all of them with higher education, as you would expect of faculty members. Most described themselves as being sedentary or as taking occasional exercise, with only 15.9% (7/44) taking regular exercise. Preexisting diseases were reported by 15 travelers. Most trips lasted usually one week or less. Duration of the travel was related to the destination, with (12h) or longer trips being taken by 68.2% (30/44) of travelers, and the others taking shorter (3h) domestic trips. Most travelling was made by air (41/44) and only 31.8% (14/44) of the trips were motivated by leisure. Field research trips were not reported. Specific health counseling previous to travel was reported only by two (4.5%). Twenty seven of them (61.4%) reported updated immunization, but 11/30 reported unchecked immunizations. 30% (9/30) reported travel without any health insurance coverage. As a whole group, 6 (13.6%) travelers reported at least one health problem attributed to the trip. All of them were males travelling abroad. Five presented respiratory infections, such as influenza and common cold, one neurological, one orthopedic, one social and one hypertension. There were no gender differences regarding age groups, destination, type of transport, previous health counseling, leisure travel motivation or pre-existing diseases. Interestingly

  18. Terrestrial Ecosystem Responses to Species Gains and Losses

    NARCIS (Netherlands)

    Wardle, D.A.; Bardgett, R.D.; Callaway, R.; Putten, van der W.H.

    2011-01-01

    Ecosystems worldwide are losing some species and gaining others, resulting in an interchange of species that is having profound impacts on how these ecosystems function. However, research on the effects of species gains and losses has developed largely independently of one another. Recent conceptual

  19. Terrestrial ecosystem responses to species gains and losses

    NARCIS (Netherlands)

    Wardle, D.A.; Bardgett, R.D.; Callaway, R.M.; Van der Putten, W.H.

    2011-01-01

    Ecosystems worldwide are losing some species and gaining others, resulting in an interchange of species that is having profound impacts on how these ecosystems function. However, research on the effects of species gains and losses has developed largely independently of one another. Recent conceptual

  20. Giant Cell Tumor of Rib Arising Anteriorly as a Large Inframammary Mass: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Amit Sharma

    2012-01-01

    posteriorly. The rarity of this tumor poses diagnostic and therapeutic problems for physicians, especially when it is located in the anterior arc of the rib in close proximity to the breasts in female patients. Case Presentation. We report the case of a 32-year-old Asian female with a giant cell tumor of her anterior rib, presenting as a large inframammary mass. Computed tomography showed a tumor arising from the 7th rib anteriorly with marginal sclerosis, cortical destruction, and a soft tissue mass. She was treated with surgical resection, and the defect was reconstructed primarily. The surgical specimen measured 28.0 × 24.0 cm. The microscopic examination showed a large number of multinucleate giant cells scattered over the parenchyma. Patient recovered uneventfully and continues to be recurrence-free six years after surgical resection. Conclusion. We report the largest known case of giant cell tumor arising from the anterior aspect of a rib. We recommend including giant cell tumor in the differential diagnosis of chest wall masses especially in female patients, regardless of the size on clinical examination.

  1. Rotation sequence to report humerothoracic kinematics during 3D motion involving large horizontal component: application to the tennis forehand drive.

    Science.gov (United States)

    Creveaux, Thomas; Sevrez, Violaine; Dumas, Raphaël; Chèze, Laurence; Rogowski, Isabelle

    2018-03-01

    The aim of this study was to examine the respective aptitudes of three rotation sequences (Y t X f 'Y h '', Z t X f 'Y h '', and X t Z f 'Y h '') to effectively describe the orientation of the humerus relative to the thorax during a movement involving a large horizontal abduction/adduction component: the tennis forehand drive. An optoelectronic system was used to record the movements of eight elite male players, each performing ten forehand drives. The occurrences of gimbal lock, phase angle discontinuity and incoherency in the time course of the three angles defining humerothoracic rotation were examined for each rotation sequence. Our results demonstrated that no single sequence effectively describes humerothoracic motion without discontinuities throughout the forehand motion. The humerothoracic joint angles can nevertheless be described without singularities when considering the backswing/forward-swing and the follow-through phases separately. Our findings stress that the sequence choice may have implications for the report and interpretation of 3D joint kinematics during large shoulder range of motion. Consequently, the use of Euler/Cardan angles to represent 3D orientation of the humerothoracic joint in sport tasks requires the evaluation of the rotation sequence regarding singularity occurrence before analysing the kinematic data, especially when the task involves a large shoulder range of motion in the horizontal plane.

  2. Association between gestational weight gain and perinatal outcomes in women with chronic hypertension.

    Science.gov (United States)

    Yee, Lynn M; Caughey, Aaron B; Cheng, Yvonne W

    2017-09-01

    Gestational weight gain above or below the 2009 National Academy of Medicine guidelines has been associated with adverse maternal and neonatal outcomes. Although it has been well established that excess gestational weight gain is associated with the development of gestational hypertension and preeclampsia, the relationship between gestational weight gain and adverse perinatal outcomes among women with pregestational (chronic) hypertension is less clear. The objective of this study was to examine the relationship between gestational weight gain above and below National Academy of Medicine guidelines and perinatal outcomes in a large, population-based cohort of women with chronic hypertension. This is a population-based retrospective cohort study of women with chronic hypertension who had term, singleton, vertex births in the United States from 2012 through 2014. Prepregnancy body mass index was calculated using self-reported prepregnancy weight and height. Women were categorized into 4 groups based on gestational weight gain and prepregnancy body mass index: (1) weight gain less than, (2) weight gain within, (3) weight gain 1-19 lb in excess of, and (4) weight gain ≥20 lb in excess of the National Academy of Medicine guidelines. The χ 2 tests and multivariable logistic regression analysis were used for statistical comparisons. Stratified analyses by body mass index category were additionally performed. In this large birth cohort, 101,259 women met criteria for inclusion. Compared to hypertensive women who had gestational weight gain within guidelines, hypertensive women with weight gain ≥20 lb over National Academy of Medicine guidelines were more likely to have eclampsia (adjusted odds ratio, 1.93; 95% confidence interval, 1.54-2.42) and cesarean delivery (adjusted odds ratio, 1.60; 95% confidence interval, 1.50-1.70). Excess weight gain ≥20 lb over National Academy of Medicine guidelines was also associated with increased odds of 5-minute Apgar gain 1-19 lb

  3. Large pneumothorax in blunt chest trauma: Is a chest drain always necessary in stable patients? A case report.

    Science.gov (United States)

    Idris, Baig M; Hefny, Ashraf F

    2016-01-01

    Pneumothorax is the most common potentially life-threatening blunt chest injury. The management of pneumothorax depends upon the etiology, its size and hemodynamic stability of the patient. Most clinicians agree that chest drainage is essential for the management of traumatic large pneumothorax. Herein, we present a case of large pneumothorax in blunt chest trauma patient that resolved spontaneously without a chest drain. A 63- year- old man presented to the Emergency Department complaining of left lateral chest pain due to a fall on his chest at home. On examination, he was hemodynamically stable. An urgent chest X-ray showed evidence of left sided pneumothorax. CT scan of the chest showed pneumothorax of more than 30% of the left hemithorax (around 600ml of air) with multiple left ribs fracture. Patient refused tube thoracostomy and was admitted to surgical department for close observation. The patient was managed conservatively without chest tube insertion. A repeat CT scan of the chest has shown complete resolution of the pneumothorax. The clinical spectrum of pneumothorax varies from asymptomatic to life threatening tension pneumothorax. In stable patients, conservative management can be safe and effective for small pneumothorax. To the best of our knowledge, this is the second reported case in the English literature with large pneumothorax which resolved spontaneously without chest drain. Blunt traumatic large pneumothorax in a clinically stable patient can be managed conservatively. Current recommendations for tube placement may need to be reevaluated. This may reduce morbidity associated with chest tube thoracostomy. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  4. The Experience Elicited by Hallucinogens Presents the Highest Similarity to Dreaming within a Large Database of Psychoactive Substance Reports

    Science.gov (United States)

    Sanz, Camila; Zamberlan, Federico; Erowid, Earth; Erowid, Fire; Tagliazucchi, Enzo

    2018-01-01

    Ever since the modern rediscovery of psychedelic substances by Western society, several authors have independently proposed that their effects bear a high resemblance to the dreams and dreamlike experiences occurring naturally during the sleep-wake cycle. Recent studies in humans have provided neurophysiological evidence supporting this hypothesis. However, a rigorous comparative analysis of the phenomenology (“what it feels like” to experience these states) is currently lacking. We investigated the semantic similarity between a large number of subjective reports of psychoactive substances and reports of high/low lucidity dreams, and found that the highest-ranking substance in terms of the similarity to high lucidity dreams was the serotonergic psychedelic lysergic acid diethylamide (LSD), whereas the highest-ranking in terms of the similarity to dreams of low lucidity were plants of the Datura genus, rich in deliriant tropane alkaloids. Conversely, sedatives, stimulants, antipsychotics, and antidepressants comprised most of the lowest-ranking substances. An analysis of the most frequent words in the subjective reports of dreams and hallucinogens revealed that terms associated with perception (“see,” “visual,” “face,” “reality,” “color”), emotion (“fear”), setting (“outside,” “inside,” “street,” “front,” “behind”) and relatives (“mom,” “dad,” “brother,” “parent,” “family”) were the most prevalent across both experiences. In summary, we applied novel quantitative analyses to a large volume of empirical data to confirm the hypothesis that, among all psychoactive substances, hallucinogen drugs elicit experiences with the highest semantic similarity to those of dreams. Our results and the associated methodological developments open the way to study the comparative phenomenology of different altered states of consciousness and its relationship with non-invasive measurements of brain physiology. PMID

  5. Self-reported physical exposure association with medial and lateral epicondylitis incidence in a large longitudinal study.

    Science.gov (United States)

    Descatha, Alexis; Dale, Ann Marie; Jaegers, Lisa; Herquelot, Eléonore; Evanoff, Bradley

    2013-09-01

    Although previous studies have related occupational exposure and epicondylitis, the evidence is moderate and mostly based on cross-sectional studies. Suspected physical exposures were tested over a 3-year period in a large longitudinal cohort study of workers in the USA. In a population-based study including a variety of industries, 1107 newly employed workers were examined; only workers without elbow symptoms at baseline were included. Baseline questionnaires collected information on personal characteristics and self-reported physical work exposures and psychosocial measures for the current or most recent job at 6 months. Epicondylitis (lateral and medial) was the main outcome, assessed at 36 months based on symptoms and physical examination (palpation or provocation test). Logistic models included the most relevant associated variables. Of 699 workers tested after 36 months who did not have elbow symptoms at baseline, 48 suffered from medial or lateral epicondylitis (6.9%), with 34 cases of lateral epicondylitis (4.9%), 30 cases of medial epicondylitis (4.3%) and 16 workers who had both. After adjusting for age, lack of social support and obesity, consistent associations were observed between self-reported wrist bending/twisting and forearm twisting/rotating/screwing motion and future cases of medial or lateral epicondylitis (ORs 2.8 (1.2 to 6.2) and 3.6 (1.2 to 11.0) in men and women, respectively). Self-reported physical exposures that implicate repetitive and extensive/prolonged wrist bend/twisting and forearm movements were associated with incident cases of lateral and medial epicondylitis in a large longitudinal study, although other studies are needed to better specify the exposures involved.

  6. The Experience Elicited by Hallucinogens Presents the Highest Similarity to Dreaming within a Large Database of Psychoactive Substance Reports

    Directory of Open Access Journals (Sweden)

    Camila Sanz

    2018-01-01

    Full Text Available Ever since the modern rediscovery of psychedelic substances by Western society, several authors have independently proposed that their effects bear a high resemblance to the dreams and dreamlike experiences occurring naturally during the sleep-wake cycle. Recent studies in humans have provided neurophysiological evidence supporting this hypothesis. However, a rigorous comparative analysis of the phenomenology (“what it feels like” to experience these states is currently lacking. We investigated the semantic similarity between a large number of subjective reports of psychoactive substances and reports of high/low lucidity dreams, and found that the highest-ranking substance in terms of the similarity to high lucidity dreams was the serotonergic psychedelic lysergic acid diethylamide (LSD, whereas the highest-ranking in terms of the similarity to dreams of low lucidity were plants of the Datura genus, rich in deliriant tropane alkaloids. Conversely, sedatives, stimulants, antipsychotics, and antidepressants comprised most of the lowest-ranking substances. An analysis of the most frequent words in the subjective reports of dreams and hallucinogens revealed that terms associated with perception (“see,” “visual,” “face,” “reality,” “color”, emotion (“fear”, setting (“outside,” “inside,” “street,” “front,” “behind” and relatives (“mom,” “dad,” “brother,” “parent,” “family” were the most prevalent across both experiences. In summary, we applied novel quantitative analyses to a large volume of empirical data to confirm the hypothesis that, among all psychoactive substances, hallucinogen drugs elicit experiences with the highest semantic similarity to those of dreams. Our results and the associated methodological developments open the way to study the comparative phenomenology of different altered states of consciousness and its relationship with non-invasive measurements of brain

  7. Gaining the Edge: Connecting with the Millennials

    Science.gov (United States)

    2008-12-01

    Cleaver’s and Partridge’s) entered Americans’ living rooms nightly. The Osmond’s and Beatles captivated music of the Boomer’s youth. Powerful...AIR WAR COLLEGE AIR UNIVERSITY GAINING THE EDGE: CONNECTING WITH THE MILLENNIALS by Kay A. Smith, Lt Col, USAF A Research Report Submitted to... the Faculty In Partial Fulfillment of the Graduation Requirements 1 December 2008 DISCLAIMER The views expressed in this academic research

  8. Factors associated with self-reported number of teeth in a large national cohort of Thai adults

    Directory of Open Access Journals (Sweden)

    Yiengprugsawan Vasoontara

    2011-11-01

    Full Text Available Abstract Background Oral health in later life results from individual's lifelong accumulation of experiences at the personal, community and societal levels. There is little information relating the oral health outcomes to risk factors in Asian middle-income settings such as Thailand today. Methods Data derived from a cohort of 87,134 adults enrolled in Sukhothai Thammathirat Open University who completed self-administered questionnaires in 2005. Cohort members are aged between 15 and 87 years and resided throughout Thailand. This is a large study of self-reported number of teeth among Thai adults. Bivariate and multivariate logistic regressions were used to analyse factors associated with self-reported number of teeth. Results After adjusting for covariates, being female (OR = 1.28, older age (OR = 10.6, having low income (OR = 1.45, having lower education (OR = 1.33, and being a lifetime urban resident (OR = 1.37 were statistically associated (p Conclusions This study addresses the gap in knowledge on factors associated with self-reported number of teeth. The promotion of healthy childhoods and adult lifestyles are important public health interventions to increase tooth retention in middle and older age.

  9. Reported frequency of physical activity in a large epidemiological study: relationship to specific activities and repeatability over time

    Directory of Open Access Journals (Sweden)

    Reeves Gillian K

    2011-06-01

    Full Text Available Abstract Background How overall physical activity relates to specific activities and how reported activity changes over time may influence interpretation of observed associations between physical activity and health. We examine the relationships between various physical activities self-reported at different times in a large cohort study of middle-aged UK women. Methods At recruitment, Million Women Study participants completed a baseline questionnaire including questions on frequency of strenuous and of any physical activity. About 3 years later 589,896 women also completed a follow-up questionnaire reporting the hours they spent on a range of specific activities. Time spent on each activity was used to estimate the associated excess metabolic equivalent hours (MET-hours and this value was compared across categories of physical activity reported at recruitment. Additionally, 18,655 women completed the baseline questionnaire twice, at intervals of up to 4 years; repeatability over time was assessed using the weighted kappa coefficient (κweighted and absolute percentage agreement. Results The average number of hours per week women reported doing specific activities was 14.0 for housework, 4.5 for walking, 3.0 for gardening, 0.2 for cycling, and 1.4 for all strenuous activity. Time spent and the estimated excess MET-hours associated with each activity increased with increasing frequency of any or strenuous physical activity reported at baseline (tests for trend, P weighted = 0.71 for questionnaires administered less than 6 months apart, and 52% (κweighted = 0.51 for questionnaires more than 2 years apart. Corresponding values for any physical activity were 57% (κweighted = 0.67 and 47% (κweighted = 0.58. Conclusions In this cohort, responses to simple questions on the frequency of any physical activity and of strenuous activity asked at baseline were associated with hours spent on specific activities and the associated estimated excess MET

  10. Measured stimulated Raman gain in methane

    International Nuclear Information System (INIS)

    Lopert, R.B.

    1983-01-01

    This report is about the stimulated Raman effect in methane due to the nu 1 vibration. For various gas pressures between 150 torr and 30 atm, the Raman lineshape function was both experimentally measured and synthesized using a computer model. The stimulated Raman gain was measured by sending a pump laser beam provided by an argon-ion laser and a weak probe beam provided by a tunable dye laser through a cell of methane gas. The stimulated Raman effect caused some of the energy from the pump beam to be transferred to the probe beam. The intensity of the pump beam was low so the gain of the probe beam was on the order of parts per million. A two detector arrangement and a differential amplifier system that had a feedback loop to balance the detectors was constructed to measure the small gains. A detailed description of this detection system that was able to measure gains as small as 0.2 parts per million is provided

  11. A wide range and high speed automatic gain control

    International Nuclear Information System (INIS)

    Tacconi, E.; Christiansen, C.

    1993-05-01

    Automatic gain control (AGC) techniques have been largely used since the beginning of electronics, but in most of the applications the dynamic response is slow compared with the carrier frequency. The problem of developing an automatic gain control with high dynamic response and wide control range simultaneously is analyzed in this work. An ideal gain control law, with the property that the total loop gain remains constant independent of the carrier amplitude, is obtained. The resulting AGC behavior is compared by computer simulations with a linear multiplier AGC. The ideal gain control law can be approximated using a transconductance amplifier. A practical circuit that has been used at CERN in the radio frequency loops of the Booster Synchrotron is presented. The circuit has high speed and 80-dB gain control range

  12. Windfall gains, political economy and economic development

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Olsson, Ola

    2008-01-01

    Natural resource rents and foreign aid have the character of windfall gains that affect economic outcomes both directly and indirectly. Several studies have shown that the indirect effect typically works via institutions like corruption. In this article, we offer a theoretical framework for a joi...... in a large cross-section of countries. Our results suggest that whereas more aid means less corruption, natural resource rents is positively correlated with corruption, although both relationships are non-linear......Natural resource rents and foreign aid have the character of windfall gains that affect economic outcomes both directly and indirectly. Several studies have shown that the indirect effect typically works via institutions like corruption. In this article, we offer a theoretical framework for a joint...

  13. Feedback Loop Gains and Feedback Behavior (1996)

    DEFF Research Database (Denmark)

    Kampmann, Christian Erik

    2012-01-01

    Linking feedback loops and system behavior is part of the foundation of system dynamics, yet the lack of formal tools has so far prevented a systematic application of the concept, except for very simple systems. Having such tools at their disposal would be a great help to analysts in understanding...... large, complicated simulation models. The paper applies tools from graph theory formally linking individual feedback loop strengths to the system eigenvalues. The significance of a link or a loop gain and an eigenvalue can be expressed in the eigenvalue elasticity, i.e., the relative change...... of an eigenvalue resulting from a relative change in the gain. The elasticities of individual links and loops may be found through simple matrix operations on the linearized system. Even though the number of feedback loops can grow rapidly with system size, reaching astronomical proportions even for modest systems...

  14. Spontaneous indices are inconsistent with arterial baroreflex gain.

    Science.gov (United States)

    Lipman, Ruth D; Salisbury, Julie K; Taylor, J Andrew

    2003-10-01

    Spontaneously occurring, parallel fluctuations in arterial pressure and heart period are frequently used as indices of baroreflex function. Despite the convenience of spontaneous indices, their relation to the arterial baroreflex remains unclear. Therefore, in 97 volunteers, we derived 5 proposed indices (sequence method, alpha-index, transfer function, low-frequency transfer function, and impulse response function), compared them with arterial baroreflex gain (by the modified Oxford pharmacologic technique), and examined their relation to carotid distensibility and respiratory sinus arrhythmia. The subjects comprised men and women (n=41) aged 25 to 86 years, 30% of whom had established coronary artery disease. Generally, the indices were correlated with each other (except alpha-index and low-frequency transfer function) and with baroreflex gain. However, the Bland-Altman method demonstrated that the spontaneous indices had limits of agreement as large as the baroreflex gain itself. Even in individuals within the lowest tertile of baroreflex gain for whom baroreflex gain appears to be the most clinically relevant, spontaneous indices failed to relate to baroreflex gain. In fact, for these individuals, there was no correlation between any index and baroreflex gain. Forward stepwise linear regression showed that all spontaneous indices and baroreflex gain were related to respiratory sinus arrhythmia, but only baroreflex gain was related to carotid distensibility. Therefore, these data suggest that spontaneous indices are inadequate estimates of gain and are inconsistent with arterial baroreflex function.

  15. Solar total energy-large scale experiment, Shenandoah, Georgia site. Annual report, June 1977--June 1978. [For Bleyle Knitwear Plant

    Energy Technology Data Exchange (ETDEWEB)

    None,

    1978-06-01

    The site was described in terms of location, suitably, accessibility, and other factors. Detailed descriptions of the Solar Total Energy-Large Scale Experiment Application (STE-LSE) (Bleyle of America, Inc., Knitwear Plant), the DOE owned Meteorology Station operating at the site, and the instrumentation provided by the Georgia Power Company to measure energy usage within the knitwear plant are included. A detailed report of progress is given at the Shenandoah Site, introduced by the STE-LSE schedule and the Cooperative Agreement work tasks. Progress is described in terms of the following major task areas: site/application; instrumentation/data acquisition; meteorology station; site to STES interface; information dissemination. A brief overview of milestones to be accomplished is given, followed by these appendices: solar easement agreement, interface drawing set, and additional site background data. (MHR)

  16. Application of concentrated growth factors in reconstruction of bone defects after removal of large jaw cysts: The two cases report

    Directory of Open Access Journals (Sweden)

    Mirković Siniša

    2015-01-01

    Full Text Available Introduction. Coagulation and blood clot formation in bone defects is sometimes followed by retraction of a blood clot and serum extrusion, thus producing peripheral serum-filled spaces between bony wall and coagulum. This can result in a higher incidence of postoperative complications. Stabilization of blood coagulum, which enables successful primary healing, may be accomplished by autotransplantation, allotransplantation, xenotransplantation, or application of autologous platelet concentrate and concentrated growth factors (CGF. Case report. Two patients with large cystic lesions in the upper and lower jaw were presented. In both patients postoperative bony defects were filled with autologous fibrin rich blocks containing CGF. Postoperative course passed uneventfully. Conclusion. Application of fibrin rich blocks containing CGF is one of the possible methods for reconstruction of bone defects. CGF can be applied alone or mixed with a bone graft. The method is relatively simple, without risk of transmissible and allergic diseases and economically feasible.

  17. Report of experience with large dose single upper and lower half-body irradiation. 3. Hematological and serological findings

    Energy Technology Data Exchange (ETDEWEB)

    Dalluege, K H; Eichhorn, H J; Grunau, H [Akademie der Wissenschaften der DDR, Berlin. Zentralinstitut fuer Krebsforschung

    1981-08-01

    The reaction of hematological and serological parameters in 47 patients having received a large dose single irradiation of the upper and the parvicellular bronchial carcinoma, resp., of the upper and of the lower half of the body with 8.4 Gy for the mid-line is reported. Different positions of the patients during irradiation and different fractionations were compared. Subdivision of the half-body irradiation dose, anteroposterior direction of irradiation and partial sparing of the extremities during treatment proved to be the most careful method for the leukopoietic system because the leukocytes reached their initial values 6 weeks and the lymphocytes 2 months after irradiation. Serum aldolase is a suitable parameter for tumor response and for the demonstration of eventually not yet known metastases in the irradiated half of the body with an increase of the values above 8 IU per liter after irradiation. Creatine kinase is an indicator of the radiation response of the muscles.

  18. Marsupialization of a large dentigerous cyst in the mandible with orthodontic extrusion of three impacted teeth. A case report.

    Science.gov (United States)

    Abu-Mostafa, Nedal; Abbasi, Arshad

    2017-09-01

    The dentigerous cyst (DC) is the most common type of developmental odontogenic cyst. It is usually asymptomatic and associated with the crown of an unerupted or impacted tooth. However, after a long duration, it is likely to cause significant bone resorption, cortical expansion, and tooth displacement. This report presents a large infected DC in the mandible of a 12-year-old female patient. The DC was located inferior to badly decayed primary molars and surrounded three impacted permanent teeth: canine, first premolar, which had a dilacerated root, and second premolar. The DC was treated successfully by marsupialization and extrusion of the impacted teeth. In conclusion, the combination of marsupialization with orthodontic extrusion is a conservative, efficient protocol that stimulates bone healing and promotes the eruption of cyst-associated teeth even if they are deeply impacted, crowded, or have a dilacerated root. Key words: Dentigerous cyst, marsupialization, impacted teeth, orthodontic extrusion, dilacerated root.

  19. A large osteoid osteoma of the mandibular condyle causing conductive hearing loss: a case report and review of literature.

    Science.gov (United States)

    Richardson, Sunil; Khandeparker, Rakshit Vijay; Sharma, Kapil

    2017-04-01

    Osteoid osteomas are benign skeletal neoplasms that are commonly encountered in the bones of the lower extremities, but are exceedingly rare in jaw bones with a prevalence of less than 1%. This unique clinical entity is usually seen in younger individuals, with nocturnal pain and swelling as its characteristic clinical manifestations. The size of the lesion is rarely found to be more than 2 cm. We hereby report a rare case of osteoid osteoma originating from the neck of the mandibular condyle that grew to large enough proportions to result in conductive hearing loss in addition to pain, swelling and restricted mouth opening. In addition, an effort has been made to review all the documented cases of osteoid osteomas of the jaws that have been published in the literature thus far.

  20. Large area nuclear particle detectors using ET materials, phase 2. Final report, 9 May 1988-9 May 1990

    International Nuclear Information System (INIS)

    Wrigley, C.Y.; Storti, G.M.; Walter, L.; Mathews, S.

    1990-05-01

    This report presents work done under a Phase 2 SBIR contract for demonstrating large area detector planes utilizing Quantex electron trapping materials as a film medium for storing high-energy nuclide impingement information. The detector planes utilize energy dissipated by passage of the high-energy nuclides to produce localized populations of electrons stored in traps. Readout of the localized trapped electron populations is effected by scanning the ET plane with near-infrared, which frees the trapped electrons and results in optical emission at visible wavelengths. The effort involved both optimizing fabrication technology for the detector planes and developing a readout system capable of high spatial resolution for displaying the recorded nuclide passage tracks

  1. Large cell/anaplastic medulloblastoma with myogenic, melanotic and neuronal differentiation: A case report of a rare tumor

    Directory of Open Access Journals (Sweden)

    Amany A. Fathaddin

    2014-01-01

    Full Text Available Medulloblastoma is an embryonal neuroepithelial tumor of the cerebellum and is the most common malignant central nervous system tumor in children. Different histological variants and patterns have been described. The classic variant represents the majority of cases. This report describes a rare case of large cell/anaplastic medulloblastoma with myogenic, melanotic and neuronal differentiation arising in the cerebellum of a 3-year-old boy who presented with headache and vomiting. Magnetic resonance imaging demonstrated a heterogeneously enhanced lesion in the fourth ventricle. Surgical resection of the tumor was accomplished, but a residual tumor was left behind because of the involvement of the brainstem. Postoperatively, the patient received chemotherapy and radiotherapy. Currently, 20 months after treatment, the patient has survived without further progression. Pathological examination revealed a high grade primitive neuronal tumor with foci of myogenic features, melanin containing epithelial elements and ganglion-like cells, which were confirmed by immunohistochemistry.

  2. FALSIRE Phase II. CSNI project for Fracture Analyses of Large-Scale International Reference Experiments (Phase II). Comparison report

    International Nuclear Information System (INIS)

    Sievers, J.; Schulz, H.; Bass, R.; Pugh, C.; Keeney, J.

    1996-11-01

    A summary of Phase II of the Project for Fracture Analysis of Large-Scale International Reference Experiments (FALSIRE) is presented. A FALSIRE II Workshop focused on analyses of reference fracture experiments. More than 30 participants representing 22 organizations from 12 countries took part in the workshop. Final results for 45 analyses of the reference experiments were received from the participating analysts. For each experiment, analysis results provided estimates of variables that include temperature, crack-mouth-opening displacement, stress, strain, and applied K and J values. The data were sent electronically to the Organizing Committee, who assembled the results into a comparative data base using a special-purpose computer program. A comparative assessment and discussion of the analysis results are presented in the report. Generally, structural responses of the test specimens were predicted with tolerable scatter bands. (orig./DG)

  3. Matrix-induced autologous chondrocyte implantation for a large chondral defect in a professional football player: a case report

    Directory of Open Access Journals (Sweden)

    Beyzadeoglu Tahsin

    2012-06-01

    Full Text Available Abstract Introduction Matrix-assisted autologous chondrocyte implantation is a well-known procedure for the treatment of cartilage defects, which aims to establish a regenerative milieu and restore hyaline cartilage. However, much less is known about third-generation autologous chondrocyte implantation application in high-level athletes. We report on the two-year follow-up outcome after matrix-assisted autologous chondrocyte implantation to treat a large cartilage lesion of the lateral femoral condyle in a male Caucasian professional football player. Case presentation A 27-year-old male Caucasian professional football player was previously treated for cartilage problems of his left knee with two failed microfracture procedures resulting in a 9 cm2 Outerbridge Grade 4 chondral lesion at his lateral femoral condyle. Preoperative Tegner-Lysholm and Brittberg-Peterson scores were 64 and 58, and by the second year they were 91 and 6. An evaluation with magnetic resonance imaging demonstrated filling of the defect with the signal intensity of the repair tissue resembling healthy cartilage. Second-look arthroscopy revealed robust, smooth cartilage covering his lateral femoral condyle. He returned to his former competitive level without restrictions or complaints one year after the procedure. Conclusions This case illustrates that robust cartilage tissue can be obtained with a matrix-assisted autologous chondrocyte implantation procedure even after two failed microfracture procedures in a large (9 cm2 cartilage defect. To the best of our knowledge, this is the first case report on the application of the third-generation cell therapy treatment technique, matrix-assisted autologous chondrocyte implantation, in a professional football player.

  4. Early reconstruction of bone defect created after initial surgery of a large keratocystic odontogenic tumor: A case report

    Directory of Open Access Journals (Sweden)

    Matijević Stevo

    2013-01-01

    Full Text Available Introduction. Keratocystic odontogenic tumor (KCOT is defined as a benign cystic neoplasm of the jaws of odontogenic origin with a high rate of recurrence. The most lesions occur in the posterior part of the mandible. Treatment of KCOT remains controversial, but the goals of treatment should involve eliminating the potential for recurrence while minimizing surgical morbidity. However, another significant therapeutic problem related to the management of KCOT is an adequate and early reconstruction of the existing jaw defect, as well as appropriate aesthetic and functional rehabilitation of a patient, especially in cases of a very large destruction of the jaws bone. Case report. We presented a 65-year-old female patient with very large KCOT of the mandible. Orthopantomographic radiography showed a very large elliptical multilocular radiolucency, located on the right side of the mandible body and the ascending ramus of the mandible, with radiographic evidence of cortical perforation at the anterior border of the mandibular ramus and the superior border of the alveolar part of the mandible. The surgical treatment included two phases. In the first phase, the tumor was removed by enucleation and additional use of Carnoy solution, performing peripheral ostectomy and excision of the affected overlying mucosa, while in the second phase, restorative surgery of the existing mandibular defect was performed 6 months later. Postoperatively, we did not register any of postoperative complications, nor recurrence within 2 years of the follow-up. Conclusion. Adequate and early reconstruction of the existing jaw defect and appropriate aesthetic and functional rehabilitation of the patient should be the primary goal in the treatment of KCOT, having in mind the need for a long-term post-surgical follow-up.

  5. Development of low cost systems for co-utilisation of biomass in large power plant. Mid term review report

    Energy Technology Data Exchange (ETDEWEB)

    Livingston, W.R.

    2003-07-01

    Interest in the cofiring of biomass materials with coal in large coal-fired power stations in the UK has increased significantly in recent years in response to the potential additional income from Renewables Obligation Certificates (ROCs). It is anticipated that most coal-fired power stations in the UK will have the capability to cofire biomass materials by the end of 2003. This mid-term review report examines the various stages in the route to fully commercial operation of biomass cofiring at coal-fired power stations, the availability of suitable biomass materials in the UK and the technical options for cofiring. The factors affecting the economics of biomass cofiring in large coal-fired boilers are discussed including the delivered price of biofuels, the future value of ROCs, the development costs of cofiring projects, the 25% ceiling on cofiring imposed by the Renewables Obligation Order 2002 and the use of preblending. An overview of the current status of cofiring in the UK is presented, which includes a summary of the results of trials already carried out by operators of coal-fired power stations and a discussion of the future prospects for biomass cofiring in the UK.

  6. DNA gains at 8q23.2

    DEFF Research Database (Denmark)

    da Silva Veiga, Luciana Caricati; Bérgamo, Nádia Aparecida; dos Reis, Patrícia Pintor

    2003-01-01

    Gains or amplifications involving chromosome arm 8q are one of the most recurrent chromosomal alterations in head and neck tumors. To characterize previously reported gains, we performed fluorescence in situ hybridization (FISH) using the sequences BAC RP1179E1 and 8-centromere PMJ 128 as probes....

  7. Calibration of the SH134-20 Standard Gain Horn

    DEFF Research Database (Denmark)

    Pivnenko, Sergey; Breinbjerg, Olav

    This report documents the measurement of the linearly polarized SH134-20 Standard Gain Horn. The measurement comprises on-axis gain, on-axis polarization characteristics, and reflection coefficient at 111 frequencies in the frequency range from 22-33 GHz. The measurement was carried out at the DTU...

  8. Net Gain: A New Method for Preventing Malaria Deaths | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    A finely spun net could prevent as many as one-third of all child deaths in Africa, reports IDRC's new publication, Net Gain. Studies conducted in Gambia, Ghana, and Kenya show that the insecticide-treated mosquito net reduced the mortality rate of children under 5 years of age by up to 63 percent. Net Gain reviews and ...

  9. A progress report for the large block test of the coupled thermal-mechanical-hydrological-chemical processes

    International Nuclear Information System (INIS)

    Lin, W.; Wilder, D.G.; Blink, J.

    1994-10-01

    This is a progress report on the Large Block Test (LBT) project. The purpose of the LBT is to study some of the coupled thermal-mechanical-hydrological-chemical (TMHC) processes in the near field of a nuclear waste repository under controlled boundary conditions. To do so, a large block of Topopah Spring tuff will be heated from within for about 4 to 6 months, then cooled down for about the same duration. Instruments to measure temperature, moisture content, stress, displacement, and chemical changes will be installed in three directions in the block. Meanwhile, laboratory tests will be conducted on small blocks to investigate individual thermal-mechanical, thermal-hydrological, and thermal-chemical processes. The fractures in the large block will be characterized from five exposed surfaces. The minerals on fracture surfaces will be studied before and after the test. The results from the LBT will be useful for testing and building confidence in models that will be used to predict TMHC processes in a repository. The boundary conditions to be controlled on the block include zero moisture flux and zero heat flux on the sides, constant temperature on the top, and constant stress on the outside surfaces of the block. To control these boundary conditions, a load-retaining frame is required. A 3 x 3 x 4.5 m block of Topopah Spring tuff has been isolated on the outcrop at Fran Ridge, Nevada Test Site. Pre-test model calculations indicate that a permeability of at least 10 -15 m 2 is required so that a dryout zone can be created within a practical time frame when the block is heated from within. Neutron logging was conducted in some of the vertical holes to estimate the initial moisture content of the block. It was found that about 60 to 80% of the pore volume of the block is saturated with water. Cores from the vertical holes have been used to map the fractures and to determine the properties of the rock. A current schedule is included in the report

  10. Peritonitis secondary to traumatic duodenal laceration in the presence of a large pancreatic pseudocyst: a case report

    Directory of Open Access Journals (Sweden)

    Seenath Marlon M

    2011-10-01

    Full Text Available Abstract Introduction A pancreatic pseudocyst is a common sequela of severe acute pancreatitis. Commonly, it presents with abdominal pain and a mass in the epigastrium several weeks after the acute episode and can be managed conservatively, endoscopically or surgically. We report a patient with a pancreatic pseudocyst awaiting endoscopic therapy who developed a life-threatening complication following a rather innocuous trauma to the abdomen. Case presentation A 23-year-old Asian male student presented as an emergency with an acute abdomen a week after a minor trauma to his upper abdomen. The injury occurred when he was innocently punched in the abdomen by a friend. He experienced only moderate discomfort briefly at the time. His past medical history included coeliac disease and an admission four months previously with severe acute pancreatitis. He was hospitalized for 15 days; his pancreatitis was thought to be due to alcohol binge drinking on weekends. Ultrasound scanning showed no evidence of gallstone disease. Five days after the trauma, he became anorexic, lethargic and feverish and started vomiting bilious content. Seven days post-trauma, he presented to our emergency department with severe abdominal pain. An emergency laparotomy was performed where a transverse linear duodenal laceration was found at the junction of the first and second part of his duodenum, with generalized peritonitis. His stomach and duodenum were stretched over a large pancreatic pseudocyst posterior to his stomach. It was postulated that an incomplete duodenal injury (possibly a serosal tear occurred following the initial minor trauma, which was followed by local tissue necrosis at the injury site resulting in a delayed presentation of generalized peritonitis. Conclusion This is the first reported case of a traumatic duodenal laceration following minor blunt trauma in the presence of a large pancreatic pseudocyst. Minor blunt abdominal trauma in a normal healthy adult

  11. Early studies reported extreme findings with large variability: a meta-epidemiologic study in the field of endocrinology.

    Science.gov (United States)

    Wang, Zhen; Alahdab, Fares; Almasri, Jehad; Haydour, Qusay; Mohammed, Khaled; Abu Dabrh, Abd Moain; Prokop, Larry J; Alfarkh, Wedad; Lakis, Sumaya; Montori, Victor M; Murad, Mohammad Hassan

    2016-04-01

    To evaluate the presence of extreme findings and fluctuation in effect size in endocrinology. We systematically identified all meta-analyses published in 2014 in the field of endocrinology. Within each meta-analysis, the effect size of the primary binary outcome was compared across studies according to their order of publication. We pooled studies using the DerSimonian and Laird random-effects method. Heterogeneity was evaluated using the I(2) and tau(2). Twelve percent of the included 100 meta-analyses reported the largest effect size in the very first published study. The largest effect size occurred in the first 2 earliest studies in 31% of meta-analyses. When the effect size was the largest in the first published study, it was three times larger than the final pooled effect (ratio of rates, 3.26; 95% confidence interval: 1.80, 5.90). The largest heterogeneity measured by I(2) was observed in 18% of the included meta-analyses when combining the first 2 studies or 17% when combing the first 3 studies. In endocrinology, early studies reported extreme findings with large variability. This behavior of the evidence needs to be taken into account when used to formulate clinical policies. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Developmental Gains in Visuospatial Memory Predict Gains in Mathematics Achievement

    OpenAIRE

    Li, Yaoran; Geary, David C.

    2013-01-01

    Visuospatial competencies are related to performance in mathematical domains in adulthood, but are not consistently related to mathematics achievement in children. We confirmed the latter for first graders and demonstrated that children who show above average first-to-fifth grade gains in visuospatial memory have an advantage over other children in mathematics. The study involved the assessment of the mathematics and reading achievement of 177 children in kindergarten to fifth grade, inclusiv...

  13. 78 FR 74125 - Agency Information Collection Activities; Comment Request; Measuring Educational Gain in the...

    Science.gov (United States)

    2013-12-10

    ...; Comment Request; Measuring Educational Gain in the National Reporting System for Adult Education AGENCY... Educational Gain in the National Reporting System for Adult Education. OMB Control Number: 1830-0567. Type of... tests to measure and report educational gain under the NRS. Dated: December 4, 2013. Tomakie Washington...

  14. Clinical and genetic characterization of chanarin-dorfman syndrome patients: first report of large deletions in the ABHD5 gene

    Directory of Open Access Journals (Sweden)

    Prati Daniele

    2010-12-01

    Full Text Available Abstract Background Chanarin-Dorfman syndrome (CDS is a rare autosomal recessive disorder characterized by nonbullous congenital ichthyosiform erythroderma (NCIE and an intracellular accumulation of triacylglycerol (TG droplets in most tissues. The clinical phenotype involves multiple organs and systems, including liver, eyes, ears, skeletal muscle and central nervous system (CNS. Mutations in ABHD5/CGI58 gene are associated with CDS. Methods Eight CDS patients belonging to six different families from Mediterranean countries were enrolled for genetic study. Molecular analysis of the ABHD5 gene included the sequencing of the 7 coding exons and of the putative 5' regulatory regions, as well as reverse transcript-polymerase chain reaction analysis and sequencing of normal and aberrant ABHD5 cDNAs. Results Five different mutations were identified, four of which were novel, including two splice-site mutations (c.47+1G>A and c.960+5G>A and two large deletions (c.898_*320del and c.662-1330_773+46del. All the reported mutations are predicted to be pathogenic because they lead to an early stop codon or a frameshift producing a premature termination of translation. While nonsense, missense, frameshift and splice-site mutations have been identified in CDS patients, large genomic deletions have not previously been described. Conclusions These results emphasize the need for an efficient approach for genomic deletion screening to ensure an accurate molecular diagnosis of CDS. Moreover, in spite of intensive molecular screening, no mutations were identified in one patient with a confirmed clinical diagnosis of CDS, appointing to genetic heterogeneity of the syndrome.

  15. Determining productivity gains from herbaceous vegetation management with 'age-shift' calculations

    Science.gov (United States)

    David B. South; James H. Miller; Mark O. Kimberley; Curtis L. Vanderschaaf

    2006-01-01

    Gains in stand volume that result from competition control and fertilization are sometimes reported as 'percentage gains'. Because percentage gains arithmetically decline over time asstand volume increases, plantation managers have difficultyin using percentage gains to project growth and revenues. The 'age-shift' method quantifies the year...

  16. Optomechanical transistor with mechanical gain

    Science.gov (United States)

    Zhang, X. Z.; Tian, Lin; Li, Yong

    2018-04-01

    We study an optomechanical transistor, where an input field can be transferred and amplified unidirectionally in a cyclic three-mode optomechanical system. In this system, the mechanical resonator is coupled simultaneously to two cavity modes. We show that it only requires a finite mechanical gain to achieve the nonreciprocal amplification. Here the nonreciprocity is caused by the phase difference between the linearized optomechanical couplings that breaks the time-reversal symmetry of this system. The amplification arises from the mechanical gain, which provides an effective phonon bath that pumps the mechanical mode coherently. This effect is analogous to the stimulated emission of atoms, where the probe field can be amplified when its frequency is in resonance with that of the anti-Stokes transition. We show that by choosing optimal parameters, this optomechanical transistor can reach perfect unidirectionality accompanied with strong amplification. In addition, the presence of the mechanical gain can result in ultralong delay in the phase of the probe field, which provides an alternative to controlling light transport in optomechanical systems.

  17. A marked response to icotinib in a patient with large cell neuroendocrine carcinoma harboring an EGFR mutation: A case report.

    Science.gov (United States)

    Wang, Yuehong; Shen, Yi Hong; Ma, Shanni; Zhou, Jianying

    2015-09-01

    The present study reports the case of an 84-year-old male with primary pulmonary large cell neuroendocrine carcinoma (LCNEC) harboring an epidermal growth factor receptor (EGFR) gene mutation that exhibited a long-lasting response to the EGFR-tyrosine kinase inhibitor (EGFR-TKI) icotinib. The patient had an extensive smoking history, a poor performance status, and presented with an irregular mass in the middle lobe of the right lung on computed tomography (CT) and an enlarged left supraclavicular lymph node on physical examination. Right middle lobe bronchial brushing during fiberoptic bronchoscopy identified poorly-differentiated cancer cells. The left supraclavicular lymph node was biopsied and a diagnosis of metastatic LCNEC was determined. Furthermore, an EGFR exon 19 deletion was identified by DNA sequencing. Following diagnosis, icotinib was administered at a dose of 125 mg three times a day. Chest CT scans were performed after 1 month of treatment, which indicated that the tumor was in partial remission. This marked response to icotinib lasted for 8 months. Thus, the present case illustrates the possibility of identifying EGFR mutations in LCNEC and indicates that EGFR-tyrosine kinase inhibitors may be an alternative treatment strategy for patients with LCNEC harboring activating EGFR mutations.

  18. Decommissioning of the SPERT-III large leach pond at the Idaho National Engineering Laboratory. Final report

    International Nuclear Information System (INIS)

    Bradford, J.D.

    1984-04-01

    This report describes the decontamination and decommissioning of the SPERT-III large leach pond. Prior to decontamination and decommissioning the pond basin was enclosed by a mesh and barbed wire fence. An 8-in. carbon steel discharge pipe ran from the SPERT-III reactor building to the pond basin. The outlet of the discharge pipe rested on a concrete apron in the pond basin. The soil in the pond basin contained low-level radioactive contamination. The fence and apron were removed, radiologically surveyed, found to be uncontaminated, and sent to the sanitary landfill for disposal. The discharge pipe was left buried in place. The pond basin was backfilled with radiologically clean soil to reduce the surface activity to background. The area was then seeded with crested wheatgrass. A permanent marker was erected at the center of the pond basin to indicate the presence of subsurface radioactive contamination and the location of the buried discharge pipe. 5 references, 32 figures, 2 tables

  19. A large and aggressive fibromatosis in the axilla: a rare case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Duan M

    2018-05-01

    Full Text Available Mingyue Duan,1 Hua Xing,1 Keren Wang,1 Chunbo Niu,2 Chengwei Jiang,2 Lijuan Zhang,1 Shereen Ezzat,3 Le Zhang1 1Department of Breast Surgery, China-Japan Union Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 2Department of Pathology, China-Japan Union Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 3Ontario Cancer Institute and The Endocrine Oncology Site Group, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada Abstract: Aggressive fibromatosis (AF is a rare benign tumor, which occurs in the deep part of bone and muscle fibrous tissue. Clinical and pathological features can be challenging for definitive diagnosis. Here, we report a rare case of a large AF in the axilla. Interestingly, 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography showed significant increase in standard uptake value. Surgical resection yielded a spindle cell tumor likely of fibromatosis origin which was positive for β-catenin expression. Keywords: aggressive fibromatosis, desmoid-type fibromatosis, axilla, 18 F-fluorodeoxyglucose, PET/CT, β-catenin

  20. Pelvic actinomycosis presenting with a large abscess and bowel stenosis with marked response to conservative treatment: a case report

    Directory of Open Access Journals (Sweden)

    Nozawa Hiroaki

    2007-11-01

    Full Text Available Abstract Pelvic actinomycosis is a rare disease that can result in abscess formation, bowel obstruction, and other serious complications. Moreover, the correct diagnosis can seldom be established before radical surgery because the disease often mimics pelvic neoplasms. It has been recently recognized that pelvic actinomycosis is associated with long-term use of an intrauterine contraceptive device. We report a woman with a long-standing intrauterine contraceptive device who visited our hospital complaining of symptoms mimicking large bowel ileus with a subacute course. X-ray fluorography and sigmoidoscopy showed marked stenosis in the sigmoid colon but rejected the possibility of colon cancers. Abdomino-pelvic CT and MRI revealed a huge abscess lying over the urinary bladder and anterior to the uterus. Furthermore, a cervical Papanicolaou smear disclosed Actinomyces species. We removed the intrauterine device from the patient. Subsequent high-dose ampicillin administration led to dramatic shrinkage of the abscess and improved the management of the bowel movement quickly. This is a successful case of symptomatic pelvic actinomycosis that was correctly diagnosed and treated without unnecessary surgical intervention.

  1. Final Scientific/Technical Report: Electronics for Large Superconducting Tunnel Junction Detector Arrays for Synchrotron Soft X-ray Research

    Energy Technology Data Exchange (ETDEWEB)

    Warburton, William K

    2009-03-06

    Superconducting tunnel junction (STJ) detectors offer a an approach to detecting soft x-rays with energy resolutions 4-5 times better and at rates 10 faster than traditions semiconductor detectors. To make such detectors feasible, however, then need to be deployed in large arrays of order 1000 detectors, which in turn implies that their processing electronics must be compact, fully computer controlled, and low cost per channel while still delivering ultra-low noise performance so as to not degrade the STJ's performance. We report on our progress in designing a compact, low cost preamplifier intended for this application. In particular, we were able to produce a prototype preamplifier of 2 sq-cm area and a parts cost of less than $30 that matched the energy resolution of the best conventional system to date and demonstrated its ability to acquire an STJ I-V curve under computer control, the critical step for determining and setting the detectors' operating points under software control.

  2. Pressure Gain Combustion for Gas Turbines

    Science.gov (United States)

    2013-08-20

    downstream of a large  diesel  engine, they tested three turbine geometries the best experienced  a drop in efficiency of 10%.   A few people have  looked...Society of Mechanical Engineers Turbo Expo 1995 [3] Heffer, J., 2010, Integration of Pressure Gain Combustion with Gas Turbines, Ph.D. Thesis...investigated  an  axial  turbocharger  designed  for  use  downstream  of  a  large  diesel   engine,  they  tested  three  turbine geometries the best

  3. SiPM Gain Stabilization Studies for Adaptive Power Supply

    CERN Document Server

    AUTHOR|(CDS)2074257; Zalieckas, Justas; Cvach, Jaroslav; Kvasnicka, Jiri; Polak, Ivo

    2016-01-01

    We present herein gain stabilization studies of SiPMs using a climate chamber at CERN. We present results for four detectors not tested before, three from Hamamatsu and one from KETEK. Two of the Hamamatsu SiPMs are novel sensors with trenches that reduce cross talk. We use an improved readout system with a digital oscilloscope controlled with a dedicated LabView program. We improved and automized the analysis to deal with large datasets. We have measured the gain-versus-bias-voltage dependence at fixed temperature and gain-versus-temperature dependence at fixed bias voltage to determine the bias voltage dependence on temperature $V(T)$ for stable gain. We show that the gain remains stable to better than $\\pm 0.5\\%$ in the $20^\\circ \\rm C - 30^\\circ C$ temperature range if the bias voltage is properly adjusted with temperature.

  4. A State-of-the-Art Report on Technologies of Volume Reduction and Self-Disposal for Large Metal Wastes including the Steam Generator of Nuclear Power Plants

    International Nuclear Information System (INIS)

    Lee, Kune Woo; Choi, W. K.; Kim, G. Y.

    2009-06-01

    This report focuses on technologies of volume reduction and self-disposal for large metal wastes including the steam generator of nuclear power plants. This report consists of the cases of treatments and foreign and domestic technologies for steam generator replacement

  5. 2009 IOM guidelines for gestational weight gain: how well do they predict outcomes across ethnic groups?

    Science.gov (United States)

    Khanolkar, Amal R; Hanley, Gillian E; Koupil, Ilona; Janssen, Patricia A

    2017-11-13

    To determine whether the Institute Of Medicine's (IOM) 2009 guidelines for weight-gain during pregnancy are predictive of maternal and infant outcomes in ethnic minority populations. We designed a population-based study using administrative data on 181,948 women who delivered live singleton births in Washington State between 2006-2008. We examined risks of gestational hypertension, preeclampsia/eclampsia, cesarean delivery, and extended hospital stay in White, Black, Native-American, East-Asian, Hispanic, South-Asian and Hawaiian/Pacific islander women according to whether they gained more or less weight during pregnancy than recommended by IOM guidelines. We also examined risks of neonatal outcomes including Apgar score IOM guidelines for weight gain during pregnancy reduces risk for various adverse maternal outcomes in all ethnic groups studied. However, the guidelines were less predictive of infant outcomes with the exception of small and large for gestational age. GWG: Gestational weight gain; IOM/NRC; Institute of Medicine and National Research Council; NICU: Neonatal intensive care need for ventilation; SGA: Small for gestational age; LGA: Large for gestational age; BERD: Birth Events Records Database; CHARS: Comprehensive Hospital Discharge Abstract Reporting System; ICD: International Classification of Disease; LMP: Last menstrual period; OR: Odds ratio.

  6. Large cell non-Hodgkin's lymphoma masquerading as renal carcinoma with inferior vena cava thrombosis: a case report

    Directory of Open Access Journals (Sweden)

    Weissman Alan

    2011-06-01

    Full Text Available Abstract Introduction Many cancers are associated with inferior vena cava (IVC obstruction, but very few cancers have the ability to propagate within the lumen of the renal vein or the IVC. Renal cell carcinoma is the most common of these cancers. Renal cancer with IVC extension has a high rate of recurrence and a low five year survival rate. Case presentation A 62-year-old Caucasian woman previously in good health developed the sudden onset of severe reflux symptoms and right-sided abdominal pain that radiated around the right flank. A subsequent ultrasound and CT scan revealed a right upper pole renal mass with invasion of the right adrenal gland, liver, left renal vein and IVC. This appeared to be consistent with stage III renal cancer with IVC extension. Metastatic nodules were believed to be present in the right pericardial region; the superficial anterior abdominal wall; the left perirenal, abdominal and pelvic regions; and the left adrenal gland. The pattern of these metastases, as well as the invasion of the liver by the tumor, was thought to be atypical of renal cancer. A needle biopsy of a superficial abdominal wall mass revealed a surprising finding: The malignant cells were diagnostic of large-cell, B-cell non-Hodgkin's lymphoma. The lymphoma responded dramatically to systemic chemotherapy, which avoided the need for nephrectomy. Conclusion Lymphomas only rarely progress via intraluminal vascular extension. We have been able to identify only one other case report of renal lymphoma with renal vein and IVC extension. While renal cancer would have been treated with radical nephrectomy and tumor embolectomy, large-cell B-cell lymphomas are treated primarily with chemotherapy, and nephrectomy would have been detrimental. It is important to remember that, rarely, other types of cancer arise from the kidney which are not derived from the renal tubular epithelium. These may be suspected if an atypical pattern of metastases or unusual

  7. Temporal Gain Correction for X-Ray Calorimeter Spectrometers

    Science.gov (United States)

    Porter, F. S.; Chiao, M. P.; Eckart, M. E.; Fujimoto, R.; Ishisaki, Y.; Kelley, R. L.; Kilbourne, C. A.; Leutenegger, M. A.; McCammon, D.; Mitsuda, K.

    2016-01-01

    Calorimetric X-ray detectors are very sensitive to their environment. The boundary conditions can have a profound effect on the gain including heat sink temperature, the local radiation temperature, bias, and the temperature of the readout electronics. Any variation in the boundary conditions can cause temporal variations in the gain of the detector and compromise both the energy scale and the resolving power of the spectrometer. Most production X-ray calorimeter spectrometers, both on the ground and in space, have some means of tracking the gain as a function of time, often using a calibration spectral line. For small gain changes, a linear stretch correction is often sufficient. However, the detectors are intrinsically non-linear and often the event analysis, i.e., shaping, optimal filters etc., add additional non-linearity. Thus for large gain variations or when the best possible precision is required, a linear stretch correction is not sufficient. Here, we discuss a new correction technique based on non-linear interpolation of the energy-scale functions. Using Astro-HSXS calibration data, we demonstrate that the correction can recover the X-ray energy to better than 1 part in 104 over the entire spectral band to above 12 keV even for large-scale gain variations. This method will be used to correct any temporal drift of the on-orbit per-pixel gain using on-board calibration sources for the SXS instrument on the Astro-H observatory.

  8. Commutated automatic gain control system

    Science.gov (United States)

    Yost, S. R.

    1982-01-01

    A commutated automatic gain control (AGC) system was designed and built for a prototype Loran C receiver. The receiver uses a microcomputer to control a memory aided phase-locked loop (MAPLL). The microcomputer also controls the input/output, latitude/longitude conversion, and the recently added AGC system. The circuit designed for the AGC is described, and bench and flight test results are presented. The AGC circuit described actually samples starting at a point 40 microseconds after a zero crossing determined by the software lock pulse ultimately generated by a 30 microsecond delay and add network in the receiver front end envelope detector.

  9. [Fast food promotes weight gain].

    Science.gov (United States)

    Stender, Steen; Dyerberg, Jørn; Astrup, Arne V

    2007-05-07

    The total amounts of fat in a fast food menu consisting of French fries and fried Chicken Nuggets from McDonald's and KFC, respectively, bought in 35 different countries vary from 41 to 71 gram. In most countries the menu contained unacceptably high amounts of industrially-produced trans fat which contributes to an increased risk of ischaemic heart disease, weight gain, abdominal fat accumulation and type 2 diabetes. The quality of the ingredients in fast food ought to be better and the size of the portions smaller and less energy-dense so that frequent fast food meals do not increase the risk of obesity and diseases among customers.

  10. Perception of gain in U.S.-Soviet arms control

    International Nuclear Information System (INIS)

    D'Anieri, P.J.

    1991-01-01

    Most current work in the field of international cooperation focuses on the resolution of the 'prisoners dilemma.' Such work begins by assuming that the issues under consideration are defined by absolute gains, where both sides can gain simultaneously. But the realist strand of international relations literature holds that this assumption is suspect - that international relations are usually characterized by relative gains, where gain for one side comes only at the others expense. The model developed here uses the question of absolute versus relative gains not as a theoretical assumption, but as a variable to be measured empirically. The hypothesis is that whether or not the US and the Soviet Union cooperate to limit arms competition is largely determined by whether the two sides define the issue in question as one of absolute or relative gains. The 'perception of gain' hypothesis is compared to explanations at the levels of the international system (rational choice), domestic politics, and individual belief systems. Three case studies are used to compare the strengths and weaknesses of each hypothesis. The findings confirmed that perception of gain is an important independent variable affecting arms control outcomes, but none of the theories were completely supported or rejected

  11. Primary Breast Mucosa-Associated Lymphoid Tissue (MALT Lymphoma Transformation to Diffuse Large B-cell Lymphoma: A Case Report

    Directory of Open Access Journals (Sweden)

    Şerife Hülya Arslan

    2012-09-01

    Full Text Available Primary non-Hodgkin’s lymphoma (NHL of the breast constitutes 0.04%-0.53% of all malignancies and 2.2% of extra nodal lymphomas. In total, 7%-8% of all B-cell lymphomas are the mucosa-associated lymphoid tissue (MALT type, of which up to 50% of primary gastric MALT lymphoma. Herein we present a patient with breast MALT lymphoma that transformed to diffuse large B-cell lymphoma (DLBCL. A 69-year-old female presented with a mass on her left breast. Physical examination showed a 3 × 3-cm mass located 1 cm from the areola on the upper lateral quadrant of the breast at the 1 o’clock position, which was fixed and firm. Excisional biopsy was performed and pathologic examination of the specimen showed MALT lymphoma transformation to DLBCL. The patient was staged as II-EA. The rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP protocol was scheduled as treatment. Following 6 courses of R-CHOP, 2 additional courses of rituximab were administered. Positron emission tomography (PET-CT was done at the end of the treatment. PET showed that the patient was in complete remission. At the time this report was written, the patient was being followed-up at the outpatient clinic on a regular basis. Lymphoma of the breast is a rarity among malignant tumors of the breast. The most common type of lymphoma is DLBCL. Breast MALT lymphoma is extremely rare. Primary MALT lymphoma of the breast can transform from low grade to high grade and recurrence is possible; therefore, such patients should be monitored carefully for transformation.

  12. Healthcare Providers’ Perceptions and Self-Reported Fall Prevention Practices: Findings from a Large New York Health System

    Directory of Open Access Journals (Sweden)

    Matthew Lee eSmith

    2015-04-01

    Full Text Available Among older adults, falls are the leading cause of injury-related deaths and emergency department visits, and the incidence of falls in the United States is rising as the number of older Americans increases. Research has shown that falls can be reduced by modifying fall risk factors using multifactorial interventions implemented in clinical settings. However, the literature indicates many providers feel they do not know how to conduct fall risk assessments or do not have adequate knowledge about fall prevention To help healthcare providers incorporate older adult fall prevention (i.e., falls risk assessment and treatment into their clinical practice, the Centers for Disease Control and Prevention’s (CDC Injury Center has developed the STEADI (Stopping Elderly Accidents, Deaths, and Injuries tool kit. This study was conducted to identify the practice characteristics and providers’ beliefs, knowledge, and fall-related activities before they received training on how to use the STEADI tool kit. Data were collected as part of a larger State Fall Prevention Project funded by CDC’s Injury Center. Completed questionnaires were returned by 38 medical providers from 11 healthcare practices within a large New York health system. Healthcare providers ranked falls as the lowest priority of five conditions, after diabetes, cardiovascular disease, mental health, and musculoskeletal conditions. Less than 40% of the providers asked most or all of their older patients if they had fallen during the past 12 months. Less than a quarter referred their older patients to physical therapists for balance or gait training, and less than 20% referred older patients to community-based fall prevention programs. Less than 16% reported they conducted standardized functional assessments with their older patients at least once a year. These results suggest that implementing the STEADI tool kit in clinical settings could address knowledge gaps and provide the necessary

  13. Can Beta Blockers Cause Weight Gain?

    Science.gov (United States)

    ... cause weight gain? Can beta blockers cause weight gain? Answers from Sheldon G. Sheps, M.D. Yes. Weight gain can occur as a side effect of some ... and metoprolol (Lopressor, Toprol-XL). The average weight gain is about 2.6 pounds (about 1.2 ...

  14. Brillouin gain enhancement in nano-scale photonic waveguide

    Science.gov (United States)

    Nouri Jouybari, Soodabeh

    2018-05-01

    The enhancement of stimulated Brillouin scattering in nano-scale waveguides has a great contribution in the improvement of the photonic devices technology. The key factors in Brillouin gain are the electrostriction force and radiation pressure generated by optical waves in the waveguide. In this article, we have proposed a new scheme of nano-scale waveguide in which the Brillouin gain is considerably improved compared to the previously-reported schemes. The role of radiation pressure in the Brillouin gain was much higher than the role of the electrostriction force. The Brillouin gain strongly depends on the structural parameters of the waveguide and the maximum value of 12127 W-1 m-1 is obtained for the Brillouin gain.

  15. Estimating the potential gains from mergers

    DEFF Research Database (Denmark)

    Bogetoft, Peter; Wang, Dexiang

    2005-01-01

    We introduce simple production economic models to estimate the potential gains from mergers. We decompose the gains into technical ef¿ciency, size (scale) and harmony (mix) gains, and we discuss alternative ways to capture these gains. We propose to approximate the production processes using...... the non-parametric. Data Envelopment Analysis (DEA) approach, and we use the resulting operational approach to estimate the potential gains from merging agricultural extension of¿ces in Denmark....

  16. Report of a large depletion in the ozone layer over southern Brazil and Uruguay by using multi-instrumental data

    Science.gov (United States)

    Bresciani, Caroline; Dornelles Bittencourt, Gabriela; Valentin Bageston, José; Kirsch Pinheiro, Damaris; Schuch, Nelson Jorge; Bencherif, Hassan; Paes Leme, Neusa; Vaz Peres, Lucas

    2018-03-01

    Ozone is one of the chemical compounds that form part of the atmosphere. It plays a key role in the stratosphere where the ozone layer is located and absorbs large amounts of ultraviolet radiation. However, during austral spring (August-November), there is a massive destruction of the ozone layer, which is known as the Antarctic ozone hole. This phenomenon decreases ozone concentration in that region, which may affect other regions in addition to the polar one. This anomaly may also reach mid-latitudes; hence, it is called the secondary effect of the Antarctic ozone hole. Therefore, this study aims to identify the passage of an ozone secondary effect (OSE) event in the region of the city of Santa Maria - RS (29.68° S, 53.80° W) by means of a multi-instrumental analysis using the satellites TIMED/SABER, AURA/MLS, and OMI-ERS. Measurements were made in São Martinho da Serra/RS - Brazil (29.53° S, 53.85° W) using a sounding balloon and a Brewer Spectrophotometer. In addition, the present study aims to describe and analyse the influence that this stratospheric ozone reduction has on temperatures presented by these instruments, including data collected through the radio occultation technique. The event was first identified by the AURA/MLS satellite on 19 October 2016 over Uruguay. This reduction in ozone concentration was found by comparing the climatology for the years 1996-1998 for the state of Rio Grande do Sul, which is close to Uruguay. This event was already observed in Santa Maria/RS-Brazil on 20 October 2016 as presented by the OMI-ERS satellite and the Brewer Spectrophotometer. Moreover, a significant decrease was reported by the TIMED/SABER satellite in Uruguay. On 21 October, the poor ozone air mass was still over the region of interest, according to the OMI-ERS satellite, data from the sounding balloon launched in Santa Maria/RS-Brazil, and measurements made by the AURA/MLS satellite. Furthermore, the influence of ozone on the stratosphere temperature

  17. Paraneoplastic hypercalcaemia and osteolytic lesions secondary to large B-cell lymphoma: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Dora Luisa Covarrubias-Flores

    2018-04-01

    Full Text Available Introduction: Hypercalcaemia is a relatively common clinical finding, and its aetiology should be analysed in order to guide treatment. Case report: 56-year-old male presenting with hypercalcaemia, lumbar pain and osteolytic lesions in lumbar vertebrae, with large B-cell lymphoma subsequently confirmed by histology and immunohistochemistry. Discussion: Common causes are primary hyperparathyroidism, hypercalcaemia associated with chronic kidney disease and paraneoplastic hypercalcaemia (secondary to malignancy. Less common causes are granulomatous diseases, lymphoma and vitamin D toxicity, all associated with vitamin D metabolism, and thyrotoxicosis associated with lithium or thiazide diuretic consumption. Conclusion: Our patient presents with malignant hypercalcaemia, probably secondary to extra-renal conversion of 25(OHD to 1,25-dihydroxyvitamin D, which represents <1% of cases. Resumen: Introducción: Hipercalcemia es un hallazgo clínico relativamente común, deberá analizarse la etiología de la misma para normar conducta terapéutica. Caso clínico: Se presenta a masculino de 56 años de edad que debuta con hipercalcemia, lumbalgia y lesiones osteolíticas en columna vertebral lumbar, al que posteriormente se le confirma linfoma b de células grandes mediante histología e inmunohistoquímica. Discusión: Las principales causas son Hiperparatiroidismo primario, hipercalcemia asociada a enfermedad renal crónica e hipercalcemia paraneoplásica (secundaria a malignidad. Causas menos comunes son enfermedades granulomatosas, linfoma e intoxicación por Vitamina D, todas estas asociadas con el metabolismo de la Vitamina D; tirotoxicosis, asociada al consumo de litio o diuréticos tiazídicos. Conclusión: Nuestro paciente debuta con hipercalcemia maligna, probablemente secundaria a la conversión extrarrenal de 25(OHD a 1,25-dihidroxivitamina D, que representa <1% de los casos. Keywords: Paraneoplastic hypercalcaemia, Lymphoma, Osteolytic

  18. Heritability of gestational weight gain

    DEFF Research Database (Denmark)

    Andersson, Elina Scheers; Silventoinen, Karri; Tynelius, Per

    2015-01-01

    Gestational weight gain (GWG) is a complex trait involving intrauterine environmental, maternal environmental, and genetic factors. However, the extent to which these factors contribute to the total variation in GWG is unclear. We therefore examined the genetic and environmental influences...... on the variation in GWG in the first and second pregnancy in monozygotic (MZ) and dizygotic (DZ) twin mother-pairs. Further, we explored if any co-variance existed between factors influencing the variation in GWG of the mothers’ first and second pregnancies. By using Swedish nationwide record-linkage data, we...... identified 694 twin mother-pairs with complete data on their first pregnancy and 465 twin mother-pairs with complete data on their second pregnancy during 1982–2010. For a subanalysis, 143 twin mother-pairs had complete data on two consecutive pregnancies during the study period. We used structural equation...

  19. Unidirectional high gain brake stop

    Science.gov (United States)

    Lang, David J. (Inventor)

    1987-01-01

    This invention relates to a unidirectional high gain brake arrangement that includes in combination a shaft mounted for rotation within a housing. The shaft is rotatable in either direction. A brake is selectively releasably coupled to the housing and to the shaft. The brake has a first member. An intermittent motion device is respectively coupled through the first member to the housing and through a one-way clutch to the shaft. The brake also has a second member that is mechanically coupled to the first brake member and to the housing. The intermittent motion device causes the brake to be activated by movement imparted to the first brake member after a preset number of revolutions of the shaft in one direction. The brake is released by rotation of the shaft in an opposite direction whereby torque transmitted through the one-way clutch to the first brake member is removed.

  20. Boesmanland gains from nuclear wastes

    International Nuclear Information System (INIS)

    Smit, I.

    1984-01-01

    It is being claimed that the geobotany of the Boesmanland will gain from the use of the farm Vaalputs for radioactive waste disposal from the Koeberg nuclear power station. Only 1 km 2 of the 10 000 ha that was bought for the purpose will be used for the disposal of low-level radioactive wastes and 2 m 3 to 3 m 3 per year will be used for the storage of high-level radioactive wastes. The rest of the area, Nucor plans to develop as a nature reserve, restoring the natural botany and ecology. Before Vaalputs was selected as site for radioactive waste disposal, a regional analysis was done. According to this there is more or less 500 people staying within a radius of 25km from the farm. Geological surveys showed no mineral deposits of economic value. During the past 100 million years the area was also free from seismic activity

  1. Gain and loss learning differentially contribute to life financial outcomes.

    Directory of Open Access Journals (Sweden)

    Brian Knutson

    Full Text Available Emerging findings imply that distinct neurobehavioral systems process gains and losses. This study investigated whether individual differences in gain learning and loss learning might contribute to different life financial outcomes (i.e., assets versus debt. In a community sample of healthy adults (n = 75, rapid learners had smaller debt-to-asset ratios overall. More specific analyses, however, revealed that those who learned rapidly about gains had more assets, while those who learned rapidly about losses had less debt. These distinct associations remained strong even after controlling for potential cognitive (e.g., intelligence, memory, and risk preferences and socioeconomic (e.g., age, sex, ethnicity, income, education confounds. Self-reported measures of assets and debt were additionally validated with credit report data in a subset of subjects. These findings support the notion that different gain and loss learning systems may exert a cumulative influence on distinct life financial outcomes.

  2. Realized gains from block-plot coastal Douglas-fir trials in the northern Oregon Cascades

    Science.gov (United States)

    Terrence Z. Ye; Keith J.S. Jayawickrama; J. Bradley. St. Clair

    2010-01-01

    Realized gains for coastal Douglas-fir (Pseudotsuga menziesii var. menziesii) were evaluated using data collected from 15-year-old trees from five field trials planted in large block plots in the northern Oregon Cascades. Three populations with different genetic levels (elite--high predicted gain; intermediate--moderate predicted gain; and an...

  3. Calculation of gas gain fluctuations in uniform fields

    CERN Document Server

    Schindler, H; Veenhof, R

    2010-01-01

    Fluctuations of the charge amplification factor (gain) are a key element for assessing the performance of gas-based particle detectors In this report we present Monte Carlo calculations of electron avalanches based on the Magboltz program In terms of a simple model extracted from the simulation an intuitive explanation for the impact of the gas mixture and the electric field on the gain spectrum is proposed.

  4. Gain attenuation of gated framing camera

    International Nuclear Information System (INIS)

    Xiao Shali; Liu Shenye; Cao Zhurong; Li Hang; Zhang Haiying; Yuan Zheng; Wang Liwei

    2009-01-01

    The theoretic model of framing camera's gain attenuation is analyzed. The exponential attenuation curve of the gain along the pulse propagation time is simulated. An experiment to measure the coefficient of gain attenuation based on the gain attenuation theory is designed. Experiment result shows that the gain follows an exponential attenuation rule with a quotient of 0.0249 nm -1 , the attenuation coefficient of the pulse is 0.00356 mm -1 . The loss of the pulse propagation along the MCP stripline is the leading reason of gain attenuation. But in the figure of a single stripline, the gain dose not follow the rule of exponential attenuation completely, instead, there is a gain increase at the stripline bottom. That is caused by the reflection of the pulse. The reflectance is about 24.2%. Combining the experiment and theory, which design of the stripline MCP can improved the gain attenuation. (authors)

  5. Large pneumothorax in blunt chest trauma: Is a chest drain always necessary in stable patients? A case report

    Directory of Open Access Journals (Sweden)

    Baig M. Idris

    2016-01-01

    Conclusion: Blunt traumatic large pneumothorax in a clinically stable patient can be managed conservatively. Current recommendations for tube placement may need to be reevaluated. This may reduce morbidity associated with chest tube thoracostomy.

  6. Decentralized control of large transient in power systems: theory and application. Final report, January 1981-August 1983

    Energy Technology Data Exchange (ETDEWEB)

    DeCarlo, R.; Hawley, P.; Sebok, D.

    1983-08-01

    Chapter 1 describes a continuation algorithm to construct decentralized state feedback gains which place the natural frequencies (natural modes of vibration or eigenvalues) of a linearized power system at desired locations. Chapter 2 and 3 address the problem of designing a decentralized dither control for linearly interconnected synchronous machines, each of which is nonlinear. In Chapter 2, the theory finds application to the nonlinear third order model of a single machine infinite bus system where the primary control is via an ac-dc converter. Similarly Chapter 3 considers a two machine system with individual machine converters acting as the primary control. Computer simulations of the control action given various system perturbations are found in both Chapters 2 and 3.

  7. Large pneumothorax in blunt chest trauma: Is a chest drain always necessary in stable patients? A case report

    OpenAIRE

    Idris, Baig M.; Hefny, Ashraf F.

    2016-01-01

    Introduction: Pneumothorax is the most common potentially life-threatening blunt chest injury. The management of pneumothorax depends upon the etiology, its size and hemodynamic stability of the patient. Most clinicians agree that chest drainage is essential for the management of traumatic large pneumothorax. Herein, we present a case of large pneumothorax in blunt chest trauma patient that resolved spontaneously without a chest drain. Presentation of case: A 63- year- old man presented...

  8. Optimal weight gain in obese and overweight pregnant Japanese women.

    Science.gov (United States)

    Hirooka-Nakama, Junko; Enomoto, Kimiko; Sakamaki, Kentaro; Kurasawa, Kentaro; Miyagi, Etsuko; Aoki, Shigeru

    2018-03-20

    We aimed to determine the optimal gestational weight gain (GWG) in Japanese women with a Body Mass Index (BMI) ≥25 kg/m 2 . The present retrospective study investigated singleton pregnancies in 6,781 Japanese women registered in the Japan Society of Obstetrics and Gynecology system in 2013. We divided overweight and obese women into four GWG categories based on the Institute of Medicine (IOM) recommended: weight loss, small weight gain, within IOM criteria, and above IOM criteria. The adjusted odds ratios and predicted probabilities of maternal and neonatal outcomes of interest with weight change were calculated. In overweight women, GWG was associated with neonatal birth weight. In the loss and small gain subgroups, there was a significant increase in small for gestational age (SGA) and low birth weight neonates (LBW). Predicted probabilities showed the lowest risk was observed in a weight gain of 0 kg; the risk sharply increased at a gain of 11.5 kg. In obese women, weight gain increased the prevalence of large for gestational age (LGA) neonates; however; SGA was not associated with GWG. Predicted probabilities showed an increase in the risk with weight gain. The observed optimal GWG was 0 to 11.5 kg in overweight, and weight loss in obese, pregnant Japanese women.

  9. Review of health and productivity gains from better IEQ

    Energy Technology Data Exchange (ETDEWEB)

    Fisk, William J.

    2000-08-01

    The available scientific data suggest that existing technologies and procedures can improve indoor environmental quality (IEQ) in a manner that significantly increases productivity and health. While there is considerable uncertainty in the estimates of the magnitudes of productivity gains that may be obtained, the projected gains are very large. For the U.S., the estimated potential annual savings and productivity gains are $6 to $14 billion from reduced respiratory disease, $2 to $4 billion from reduced allergies and asthma, $10 to $30 billion from reduced sick building syndrome symptoms, and $20 to $160 billion from direct improvements in worker performance that are unrelated to health. Productivity gains that are quantified and demonstrated could serve as a strong stimulus for energy efficiency measures that simultaneously improve the indoor environment.

  10. Study on high gain broadband optical parametric chirped pulse amplification

    International Nuclear Information System (INIS)

    Zhang, S.K.; Fujita, M.; Yamanaka, C.; Yoshida, H.; Kodama, R.; Fujita, H.; Nakatsuka, M.; Izawa, Y.

    2000-01-01

    Optical parametric chirped pulse amplification has apparent advantages over the current schemes for high energy ultrashort pulse amplification. High gain in a single pass amplification, small B-integral, low heat deposition, high contrast ratio and, especially the extremely broad gain bandwidth with large-size crystals available bring people new hope for over multi-PW level at which the existing Nd:glass systems suffered difficulties. In this paper we present simulation and experimental studies for a high gain optical parametric chirped pulse amplification system which may be used as a preamplifier to replace the current complicated regenerative system or multi-pass Ti:sapphire amplifiers. Investigations on the amplification bandwidth and gain with BBO are performed. Analysis and discussions are also given. (author)

  11. Study of Potential Cost Reductions Resulting from Super-Large-Scale Manufacturing of PV Modules: Final Subcontract Report, 7 August 2003--30 September 2004

    Energy Technology Data Exchange (ETDEWEB)

    Keshner, M. S.; Arya, R.

    2004-10-01

    Hewlett Packard has created a design for a ''Solar City'' factory that will process 30 million sq. meters of glass panels per year and produce 2.1-3.6 GW of solar panels per year-100x the volume of a typical, thin-film, solar panel manufacturer in 2004. We have shown that with a reasonable selection of materials, and conservative assumptions, this ''Solar City'' can produce solar panels and hit the price target of $1.00 per peak watt (6.5x-8.5x lower than prices in 2004) as the total price for a complete and installed rooftop (or ground mounted) solar energy system. This breakthrough in the price of solar energy comes without the need for any significant new invention. It comes entirely from the manufacturing scale of a large plant and the cost savings inherent in operating at such a large manufacturing scale. We expect that further optimizations from these simple designs will lead to further improvements in cost. The manufacturing process and cost depend on the choice for the active layer that converts sunlight into electricity. The efficiency by which sunlight is converted into electricity can range from 7% to 15%. This parameter has a large effect on the overall price per watt. There are other impacts, as well, and we have attempted to capture them without creating undue distractions. Our primary purpose is to demonstrate the impact of large-scale manufacturing. This impact is largely independent of the choice of active layer. It is not our purpose to compare the pro's and con's for various types of active layers. Significant improvements in cost per watt can also come from scientific advances in active layers that lead to higher efficiency. But, again, our focus is on manufacturing gains and not on the potential advances in the basic technology.

  12. A child with colo-colonic intussusception due to a large colonic polyp: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Toshiaki Takahashi

    2014-01-01

    Full Text Available Colo-colonic intussusception (CI due to a colonic polyp is a rarely reported cause of intestinal obstruction in school-aged children. Hydrostatic reduction (HR and endoscopic polypectomy are minimally invasive and technically feasible for treating CI. We report a case of CI and review the literature, focusing on the diagnosis and treatment.

  13. A Selective Stratistical Study of Transaction Activity in a Large On-Line Automated Circulation System. Final Report.

    Science.gov (United States)

    Guthrie, Gerry D.

    The objective of this study was to provide the library community with basic statistical data from on-line activity in the Ohio State University Libraries' Circulation System. Over 1.6 million archive records in the circulation system for 1972 were investigated to produce subject reports of circulation activity, activity reports by collection…

  14. 26 CFR 31.6053-3 - Reporting by certain large food or beverage establishments with respect to tips.

    Science.gov (United States)

    2010-04-01

    ... receipts) from the provision of food or beverages. In the case of an operation such as a restaurant that is... employee is employed in more than one of an employer's food or beverage operations, such employee may specify what portion of his or her reported tips are attributable to a given operation when reporting tips...

  15. Compensation of propagation loss of surface plasmon polaritons with a finite-thickness dielectric gain layer

    International Nuclear Information System (INIS)

    Zhang, Xin; Liu, Haitao; Zhong, Ying

    2012-01-01

    We theoretically study the compensation of propagation loss of surface plasmon polaritons (SPPs) with the use of a finite-thickness dielectric layer with optical gain. The impacts of the gain coefficient, the gain-layer thickness and the wavelength on the loss compensation and the field distribution of the SPP mode are systematically explored with a fully vectorial method. Abnormal behaviors for the loss compensation as the gain-layer thickness increases are found and explained. Critical values of the gain coefficient and of the corresponding gain-layer thickness for just compensating the propagation loss are provided. Our results show that as the SPP propagation loss is fully compensated with a gain coefficient at a reasonably low level, the gain layer is still thin enough to ensure a large exterior SPP field at the gain-layer/air interface, which is important for achieving a strong light–matter interaction for applications such as bio-chemical sensing. (paper)

  16. Review of High Gain FELs

    International Nuclear Information System (INIS)

    Shintake, Tsumoru

    2007-01-01

    For understanding on basic radiation mechanism of the high-gain FEL based on SASE, the author presents electron-crystal interpretation of FEL radiation. In the electron-crystal, electrons are localized at regularly spaced multi-layers, which represents micro-bunching, whose spacing is equal to the radiation wavelength, and the multi-layers are perpendicular to beam axis, thus, diffracted wave creates Bragg's spots in forward and backward directions. Due to the Doppler's effect, frequency of the back-scattered wave is up-converted, generates forwardly focused X-ray. The Bragg's effect contributes focusing the X-ray beam into a spot, thus peak power becomes extremely higher by factor of typically 107. This is the FEL radiation. As well known, the total numbers of scattered photons in Bragg's spots is equal to the total elastic scattering photons from the atoms contained in the crystal. Therefore, total power in the FEL laser is same as the spontaneous radiation power from the undulator for the same beam parameter. The FEL radiation phenomenon is simple interference effect. In today's presentations, we use the laser pointer, and we frequently experience difficulty in pointing precisely or steadily in one place on the screen, since the laser spot is very small and does not spread. Exactly same to this, X-ray FEL is a highly focused beam, and pointing stability dominates productivity of experiment, thus we need special care on beam stability from linear accelerator

  17. Extensive intron gain in the ancestor of placental mammals

    Science.gov (United States)

    2011-01-01

    Background Genome-wide studies of intron dynamics in mammalian orthologous genes have found convincing evidence for loss of introns but very little for intron turnover. Similarly, large-scale analysis of intron dynamics in a few vertebrate genomes has identified only intron losses and no gains, indicating that intron gain is an extremely rare event in vertebrate evolution. These studies suggest that the intron-rich genomes of vertebrates do not allow intron gain. The aim of this study was to search for evidence of de novo intron gain in domesticated genes from an analysis of their exon/intron structures. Results A phylogenomic approach has been used to analyse all domesticated genes in mammals and chordates that originated from the coding parts of transposable elements. Gain of introns in domesticated genes has been reconstructed on well established mammalian, vertebrate and chordate phylogenies, and examined as to where and when the gain events occurred. The locations, sizes and amounts of de novo introns gained in the domesticated genes during the evolution of mammals and chordates has been analyzed. A significant amount of intron gain was found only in domesticated genes of placental mammals, where more than 70 cases were identified. De novo gained introns show clear positional bias, since they are distributed mainly in 5' UTR and coding regions, while 3' UTR introns are very rare. In the coding regions of some domesticated genes up to 8 de novo gained introns have been found. Intron densities in Eutheria-specific domesticated genes and in older domesticated genes that originated early in vertebrates are lower than those for normal mammalian and vertebrate genes. Surprisingly, the majority of intron gains have occurred in the ancestor of placentals. Conclusions This study provides the first evidence for numerous intron gains in the ancestor of placental mammals and demonstrates that adequate taxon sampling is crucial for reconstructing intron evolution. The

  18. Surgical resection of large encephalocele: a report of two cases and consideration of resectability based on developmental morphology.

    Science.gov (United States)

    Ohba, Hideo; Yamaguchi, Satoshi; Sadatomo, Takashi; Takeda, Masaaki; Kolakshyapati, Manish; Kurisu, Kaoru

    2017-03-01

    The first-line treatment of encephalocele is reduction of herniated structures. Large irreducible encephalocele entails resection of the lesion. In such case, it is essential to ascertain preoperatively if the herniated structure encloses critical venous drainage. Two cases of encephalocele presenting with large occipital mass underwent magnetic resonance (MR) imaging. In first case, the skin mass enclosed the broad space containing cerebrospinal fluid and a part of occipital lobe and cerebellum. The second case had occipital mass harboring a large portion of cerebrum enclosing dilated ventricular space. Both cases had common venous anomalies such as split superior sagittal sinus and high-positioned torcular herophili. They underwent resection of encephalocele without subsequent venous congestion. We could explain the pattern of venous anomalies in encephalocele based on normal developmental theory. Developmental theory connotes that major dural sinuses cannot herniate into the sac of encephalocele. Irrespective to its size, encephalocele can be resected safely at the neck without subsequent venous congestion.

  19. Resection of large invasive pituitary adenomas with individualized approach under neuronavigator guidance:a report of 17 cases

    OpenAIRE

    Jing-min CHENG; Jian-wen GU; Yong-qin KUANG; Wei-qi HE; Xue-min XING; Hai-dong HUANG; Yuan MA; Xun XIA; Tao YANG; Xiu-zhong ZHANG; Lin CHENG; Fan-jun ZENG

    2011-01-01

    Objective To explore the operative method and therapeutic efficacy of surgical resection of large invasive pituitary adenomas with individualized approach under neuronavigator guidance.Methods Seventeen patients(10 males and 7 females,aged from 22 to 78 years with a mean of 39.2±9.2 years) suffering from large invasive pituitary adenoma of higher than Hardy IV grade hospitalized from 2004 to 2009 were involved in the present study.All procedures were performed with the assistance of neuronavi...

  20. Radiotherapy after surgery to dermato-fibrosarcoma protuberans of large dimension. Review of the literature and case report

    International Nuclear Information System (INIS)

    Bastos, Erika Malheiros; Santos, Ivan Dunshee de Abranches Oliveira; Ferreira, Lydia Masako; Paiva, Geruza Rezende; Brunstein, Flavia; Lima, Alessandra Haddad de; Segreto, Roberto

    2004-01-01

    Dermato-fibrosarcoma protuberans is a low incidence skin neoplasia of difficult management due to its high recurrence rate. Usual treatment consists of a large resection, some times causing functional and aesthetics impairment, and despite these efforts, published data point to a recurrence rate of 11% to 53%. Recently, radiotherapy has been used modifying the unreal course of this tumor, decreasing drastically the recurrence rate when compared to surgery only. We reviewed these treatment modalities and related three cases of large recurrent tumors treated in our plastic surgery department with surgery and adjuvant radiotherapy, without recurrences after 2 years follow up. (author)

  1. Gestational weight gain among minority adolescents predicts term birth weight.

    Science.gov (United States)

    Ekambaram, Maheswari; Irigoyen, Matilde; DeFreitas, Johelin; Rajbhandari, Sharina; Geaney, Jessica Lynn; Braitman, Leonard Edward

    2018-03-07

    In adolescents, there is limited evidence on the independent and additive effect of prepregnancy body mass index (BMI) and gestational weight gain on infant birth weight. Data also show that this effect may vary by race. We sought to examine the impact of maternal prepregnancy BMI and gestational weight gain on birth weight and risk of large for gestational age (LGA) in term newborns of minority adolescent mothers. This was a retrospective cohort study of 411 singleton live term infants born to mothers ≤ 18 years. Data were abstracted from electronic medical records. Gestational weight gain was related to infant birth weight (ρ = 0.36, P gain, gestational age and Hispanic ethnicity were independent predictors of birth weight, controlling for maternal age, BMI, parity, tobacco/drug use and preeclampsia. The probability of having an LGA infant increased with weight gain [adjusted odds ratio (aOR) 1.14, 95% confidence interval (CI) 1.07-1.21] but not with BMI. Mothers who gained weight in excess of 2009 Institute of Medicine (IOM) recommendations had a greater risk of having an LGA infant compared to those who gained within recommendations (aOR 5.7, 95% CI 1.6-19.5). Minority adolescents with greater gestational weight gain had infants with higher birth weight and greater risk of LGA; BMI was not associated with either outcome. Further studies are needed to examine the applicability of the 2009 BMI-specific IOM gestational weight gain recommendations to adolescents in minority populations.

  2. An amorphous silicon photodiode with 2 THz gain-bandwidth product based on cycling excitation process

    Science.gov (United States)

    Yan, Lujiang; Yu, Yugang; Zhang, Alex Ce; Hall, David; Niaz, Iftikhar Ahmad; Raihan Miah, Mohammad Abu; Liu, Yu-Hsin; Lo, Yu-Hwa

    2017-09-01

    Since impact ionization was observed in semiconductors over half a century ago, avalanche photodiodes (APDs) using impact ionization in a fashion of chain reaction have been the most sensitive semiconductor photodetectors. However, APDs have relatively high excess noise, a limited gain-bandwidth product, and high operation voltage, presenting a need for alternative signal amplification mechanisms of superior properties. As an amplification mechanism, the cycling excitation process (CEP) was recently reported in a silicon p-n junction with subtle control and balance of the impurity levels and profiles. Realizing that CEP effect depends on Auger excitation involving localized states, we made the counter intuitive hypothesis that disordered materials, such as amorphous silicon, with their abundant localized states, can produce strong CEP effects with high gain and speed at low noise, despite their extremely low mobility and large number of defects. Here, we demonstrate an amorphous silicon low noise photodiode with gain-bandwidth product of over 2 THz, based on a very simple structure. This work will impact a wide range of applications involving optical detection because amorphous silicon, as the primary gain medium, is a low-cost, easy-to-process material that can be formed on many kinds of rigid or flexible substrates.

  3. Self-Report Measures of the Home Learning Environment in Large Scale Research: Measurement Properties and Associations with Key Developmental Outcomes

    Science.gov (United States)

    Niklas, Frank; Nguyen, Cuc; Cloney, Daniel S.; Tayler, Collette; Adams, Raymond

    2016-01-01

    Favourable home learning environments (HLEs) support children's literacy, numeracy and social development. In large-scale research, HLE is typically measured by self-report survey, but there is little consistency between studies and many different items and latent constructs are observed. Little is known about the stability of these items and…

  4. Effects of having a baby on weight gain.

    Science.gov (United States)

    Brown, Wendy J; Hockey, Richard; Dobson, Annette J

    2010-02-01

    Women often blame weight gain in early adulthood on having a baby. The aim was to estimate the weight gain attributable to having a baby, after disentangling the effects of other factors that influence weight change at this life stage. A longitudinal study of a randomly selected cohort of 6458 Australian women, aged 18-23 years in 1996, was conducted. Self-report mailed surveys were completed in 1996, 2000, 2003, and 2006, and data were analyzed in 2008. On average, women gained weight at the rate of 0.93% per year (95% CI=0.89, 0.98) or 605 g/year (95% CI=580, 635) for a 65-kg woman. Over the 10-year study period, partnered women with one baby gained almost 4 kg more, and those with a partner but no baby gained 1.8 kg more, than unpartnered childless women (after adjustment for other significant factors: initial BMI and age; physical activity, sitting time, energy intake (2003); education level, hours in paid work, and smoking). Having a baby has a marked effect on 10-year weight gain, but there is also an effect attributable to getting married or living with a partner. Social and lifestyle as well as energy balance variables should be considered when developing strategies to prevent weight gain in young adult women. Copyright 2010 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  5. Robust random number generation using steady-state emission of gain-switched laser diodes

    International Nuclear Information System (INIS)

    Yuan, Z. L.; Lucamarini, M.; Dynes, J. F.; Fröhlich, B.; Plews, A.; Shields, A. J.

    2014-01-01

    We demonstrate robust, high-speed random number generation using interference of the steady-state emission of guaranteed random phases, obtained through gain-switching a semiconductor laser diode. Steady-state emission tolerates large temporal pulse misalignments and therefore significantly improves the interference quality. Using an 8-bit digitizer followed by a finite-impulse-response unbiasing algorithm, we achieve random number generation rates of 8 and 20 Gb/s, for laser repetition rates of 1 and 2.5 GHz, respectively, with a ±20% tolerance in the interferometer differential delay. We also report a generation rate of 80 Gb/s using partially phase-correlated short pulses. In relation to the field of quantum key distribution, our results confirm the gain-switched laser diode as a suitable light source, capable of providing phase-randomized coherent pulses at a clock rate of up to 2.5 GHz.

  6. Automation of Survey Data Processing, Documentation and Dissemination: An Application to Large-Scale Self-Reported Educational Survey.

    Science.gov (United States)

    Shim, Eunjae; Shim, Minsuk K.; Felner, Robert D.

    Automation of the survey process has proved successful in many industries, yet it is still underused in educational research. This is largely due to the facts (1) that number crunching is usually carried out using software that was developed before information technology existed, and (2) that the educational research is to a great extent trapped…

  7. Gain scheduling using the Youla parameterization

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik; Stoustrup, Jakob

    1999-01-01

    Gain scheduling controllers are considered in this paper. The gain scheduling problem where the scheduling parameter vector cannot be measured directly, but needs to be estimated is considered. An estimation of the scheduling vector has been derived by using the Youla parameterization. The use...... in connection with H_inf gain scheduling controllers....

  8. Insights gained from aging research

    International Nuclear Information System (INIS)

    Blahnik, D.E.; Casada, D.A.; Edson, J.L.; Fineman, D.L.; Gunther, W.E.; Haynes, H.D.; Hoopingarner, K.R.; Jacobus, M.J.; Jarrell, D.B.; Kryter, R.C.; Magelby, H.L.; Murphy, G.A.; Subudhi, M.M.

    1992-03-01

    The US NRC Office of Nuclear Regulatory Research has implemented hardware-oriented engineering research programs to identify and resolve technical issues related to the aging of systems, structures, and components (SSCs) in operating nuclear power plants. This report provides a summary of those research results which have been compiled and published in NUREGS and related technical reports. The systems, components and structures that have been studied are organized by alphabetical order. The research results summary on the SSCs is followed by an assessment guide to emphasize inspection techniques which may be useful for detecting aging degradation in nuclear power plants. This report will be updated periodically to reflect new research results on these or other SSCs

  9. Insights gained from aging research

    Energy Technology Data Exchange (ETDEWEB)

    Blahnik, D.E.; Casada, D.A.; Edson, J.L.; Fineman, D.L.; Gunther, W.E.; Haynes, H.D.; Hoopingarner, K.R.; Jacobus, M.J.; Jarrell, D.B.; Kryter, R.C.; Magelby, H.L.; Murphy, G.A.; Subudhi, M.M.

    1992-03-01

    The US NRC Office of Nuclear Regulatory Research has implemented hardware-oriented engineering research programs to identify and resolve technical issues related to the aging of systems, structures, and components (SSCs) in operating nuclear power plants. This report provides a summary of those research results which have been compiled and published in NUREGS and related technical reports. The systems, components and structures that have been studied are organized by alphabetical order. The research results summary on the SSCs is followed by an assessment guide to emphasize inspection techniques which may be useful for detecting aging degradation in nuclear power plants. This report will be updated periodically to reflect new research results on these or other SSCs.

  10. Patient-reported safety incidents in older patients with long-term conditions: a large cross-sectional study.

    Science.gov (United States)

    Panagioti, Maria; Blakeman, Thomas; Hann, Mark; Bower, Peter

    2017-05-30

    Increasing evidence suggests that patient safety is a serious concern for older patients with long-term conditions. Despite this, there is a lack of research on safety incidents encountered by this patient group. In this study, we sought to examine patient reports of safety incidents and factors associated with reports of safety incidents in older patients with long-term conditions. The baseline cross-sectional data from a longitudinal cohort study were analysed. Older patients (n=3378 aged 65 years and over) with a long-term condition registered in general practices were included in the study. The main outcome was patient-reported safety incidents including availability and appropriateness of medical tests and prescription of wrong types or doses of medication. Binary univariate and multivariate logistic regression analyses were undertaken to examine factors associated with patient-reported safety incidents. Safety incidents were reported by 11% of the patients. Four factors were significantly associated with patient-reported safety incidents in multivariate analyses. The experience of multiple long-term conditions (OR=1.09, 95% CI 1.05 to 1.13), a probable diagnosis of depression (OR=1.36, 95% CI 1.06 to 1.74) and greater relational continuity of care (OR=1.28, 95% CI 1.08 to 1.52) were associated with increased odds for patient-reported safety incidents. Perceived greater support and involvement in self-management was associated with lower odds for patient-reported safety incidents (OR=0.95, 95% CI 0.93 to 0.97). We found that older patients with multimorbidity and depression are more likely to report experiences of patient safety incidents. Improving perceived support and involvement of patients in their care may help prevent patient-reported safety incidents. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  11. Turning value chains into social gains in Southeast Asia | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Turning value chains into social gains in Southeast Asia. Global value chains, which now form the largest share of the world's trade, involve producers and enterprises that produce goods as inputs for other producers. In Southeast Asian countries, these industries employ large numbers of low-skilled workers, particularly ...

  12. Mathematical methods in material science and large scale optimization workshops: Final report, June 1, 1995-November 30, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, A. [Minnesota Univ., Minneapolis, MN (United States). Inst. for Mathematics and Its Applications

    1996-12-01

    The summer program in Large Scale Optimization concentrated largely on process engineering, aerospace engineering, inverse problems and optimal design, and molecular structure and protein folding. The program brought together application people, optimizers, and mathematicians with interest in learning about these topics. Three proceedings volumes are being prepared. The year in Materials Sciences deals with disordered media and percolation, phase transformations, composite materials, microstructure; topological and geometric methods as well as statistical mechanics approach to polymers (included were Monte Carlo simulation for polymers); miscellaneous other topics such as nonlinear optical material, particulate flow, and thin film. All these activities saw strong interaction among material scientists, mathematicians, physicists, and engineers. About 8 proceedings volumes are being prepared.

  13. Repair of large frontal temporal parietal skull defect with digitally reconstructed titanium mesh: a report of 20 cases

    Directory of Open Access Journals (Sweden)

    Gang-ge CHENG

    2013-09-01

    Full Text Available Objective To explore the clinical effect and surgical technique of the repair of large defect involving frontal, temporal, and parietal regions using digitally reconstructed titanium mesh. Methods Twenty patients with large frontal, temporal, and parietal skull defect hospitalized in Air Force General Hospital from November 2006 to May 2012 were involved in this study. In these 20 patients, there were 13 males and 7 females, aged 18-58 years (mean 39 years, and the defect size measured from 7.0cm×9.0cm to 11.5cm×14.0cm (mean 8.5cm×12.0cm. Spiral CT head scan and digital three-dimensional reconstruction of skull were performed in all the patients. The shape and geometric size of skull defect was traced based on the symmetry principle, and then the data were transferred into digital precision lathe to reconstruct a titanium mesh slightly larger (1.0-1.5cm than the skull defect, and the finally the prosthesis was perfected after pruning the border. Cranioplasty was performed 6-12 months after craniotomy using the digitally reconstructed titanium mesh. Results The digitally reconstructed titanium mesh was used in 20 patients with large frontal, temporal, parietal skull defect. The surgical technique was relatively simple, and the surgical duration was shorter than before. The titanium mesh fit to the defect of skull accurately with satisfactory molding effect, good appearance and symmetrical in shape. No related complication was found in all the patients. Conclusion Repair of large frontal, temporal, parietal skull defect with digitally reconstructed titanium mesh is more advantageous than traditional manual reconstruction, and it can improve the life quality of patients.

  14. A Large Cystic Variant of Gastro-intestinal Stromal Tumour arising from the Jejunum: A Case Report

    OpenAIRE

    Shaikh, Salman Tehran; Upwanshi, Manish Harinarayan; Shetty, Tilakdas S.; Ghetla, Smruti R.; Gheewala, Hussain

    2015-01-01

    Gastrointestinal stromal tumours (GISTs) represent a mesenchymal neoplasm arising from the interstitial cells of cajal occurring mainly in the gastrointestinal tract. Here, we present a case of a large GIST arising from the jejunum with cystic presentation unlike the usual presentation as a solid mass. A 50-year-old male patient came with complaint of a painless mobile lump in abdomen of approximately 25 cm in size which had gradually increased over two years. Clinically mesenteric cyst was s...

  15. Maternal Obesity, Gestational Weight Gain, and Asthma in Offspring.

    Science.gov (United States)

    Polinski, Kristen J; Liu, Jihong; Boghossian, Nansi S; McLain, Alexander C

    2017-11-09

    Obesity is common among women of childbearing age; intrauterine exposure to maternal obesity or gestational weight gain may influence the development of asthma in early childhood. We examined the relationships of maternal obesity and gestational weight gain with asthma in offspring. We used data from the Early Childhood Longitudinal Study-Birth Cohort, which has a nationally representative sample of children followed from birth in 2001 through age 4 (n = 6,450). Asthma was based on parental report of a medical professional's diagnosis. We used generalized estimating equation binomial models to compute adjusted odds ratios (ORs) of childhood asthma with maternal obesity and 4 measures of gestational weight gain. Compared with children of normal-weight mothers, children of obese mothers had increased risk of asthma (adjusted OR, 1.63; 95% confidence interval [CI], 1.26-2.12) by age 4, and children born to overweight mothers had similar risk (adjusted OR, 1.25; 95% CI, 0.99-1.59). Extreme-low weight gain (gain (≥25 kg) were associated with increased risk of asthma; however, the following measures were not significant predictors of asthma: meeting gestational weight gain recommendations of the Institute of Medicine, total gestational weight gain, and weekly rate of weight gain in the second and third trimesters. Extreme-low or extreme-high gestational weight gain and maternal obesity are risk factors for early childhood asthma, further evidence of the long-term impact of intrauterine exposure on children and the need to target preconception care to improve child health indicators.

  16. Treatment of a large periradicular defect using guided tissue regeneration: A case report of 2 years follow-up and surgical re-entry

    Directory of Open Access Journals (Sweden)

    Abhijit Ningappa Gurav

    2015-01-01

    Full Text Available Periradicular (PR bone defects are common sequelae of chronic endodontic lesions. Sometimes, conventional root canal therapy is not adequate for complete resolution of the lesion. PR surgeries may be warranted in such selected cases. PR surgery provides a ready access for the removal of pathologic tissue from the periapical region, assisting in healing. Recently, the regeneration of the destroyed PR tissues has gained more attention rather than repair. In order to promote regeneration after apical surgery, the principle of guided tissue regeneration (GTR has proved to be useful. This case presents the management of a large PR lesion in a 42-year-old male subject. The PR lesion associated with 21, 11 and 12 was treated using GTR membrane, fixated with titanium minipins. The case was followed up for 2 years radiographically, and a surgical re-entry confirmed the re-establishment of the lost labial plate. Thus, the principle of GTR may immensely improve the clinical outcome and prognosis of an endodontically involved tooth with a large PR defect.

  17. Treatment of a large periradicular defect using guided tissue regeneration: A case report of 2 years follow-up and surgical re-entry

    Science.gov (United States)

    Gurav, Abhijit Ningappa; Shete, Abhijeet Rajendra; Naiktari, Ritam

    2015-01-01

    Periradicular (PR) bone defects are common sequelae of chronic endodontic lesions. Sometimes, conventional root canal therapy is not adequate for complete resolution of the lesion. PR surgeries may be warranted in such selected cases. PR surgery provides a ready access for the removal of pathologic tissue from the periapical region, assisting in healing. Recently, the regeneration of the destroyed PR tissues has gained more attention rather than repair. In order to promote regeneration after apical surgery, the principle of guided tissue regeneration (GTR) has proved to be useful. This case presents the management of a large PR lesion in a 42-year-old male subject. The PR lesion associated with 21, 11 and 12 was treated using GTR membrane, fixated with titanium minipins. The case was followed up for 2 years radiographically, and a surgical re-entry confirmed the re-establishment of the lost labial plate. Thus, the principle of GTR may immensely improve the clinical outcome and prognosis of an endodontically involved tooth with a large PR defect. PMID:26941526

  18. Self-reported Adverse Health Events Following Smallpox Vaccination in a Large Prospective Study of US Military Service Members

    Science.gov (United States)

    2007-08-27

    depression, panic disorder, other anxiety disorders, bulimia nervosa, binge‑eating disorders, and PTSD are reported in one mental health variable...22. 42. Wright KM, Huffman AH, Adler AB, Castro CA. Psychological screening program over‑ view. Mil Med 2002; 167:853‑61. 43. Brewin CR. Systematic

  19. Final Report on the “New Directions in the Variational Multiscale Formulation of Large Eddy Simulation of Turbulence”

    Energy Technology Data Exchange (ETDEWEB)

    Oberai, Assad A [Rensselaer Polytechnic Instistute

    2013-07-16

    In the report we present a summary of the new models and algorithms developed by the PI and the students supported by this grant. These developments are described in detail in ten peer-reviewed journal articles that acknowledge support from this grant.

  20. The Management of Large Components from Decommissioning to Storage and Disposal. A Report of the Task Group on Large Components of the NEA Working Party on Decommissioning and Dismantling (WPDD)

    International Nuclear Information System (INIS)

    2012-01-01

    take into account the respective requirements not only of the waste transporters and of the repository operator, but also of those of the relevant safety and transport authorities. The objectives of this study are: - to provide the basis for the different involved parties to reach convergence on the most relevant management option from an overall point of view; - to identify which criteria should be assessed in order to appreciate that relevancy, and - to promote a communication tool that benefits from the experience gained by the different countries dealing with that issue. As well as providing a tool for dialogue between all involved parties, the objective also provides a tool for assessment bodies (e.g., regulators) and stakeholders (the public) in order to appreciate the merits and the disadvantages of a given management option. Hence, this technical guide promotes an integrated approach encompassing the interests of all actors involved (e.g., decommissioners, regulators, the public at large, waste-management agencies, transporters, waste owners, etc.). Its purpose is to facilitate the review of the issues at stake through a case-by-case approach, addressing all intermediate steps, such as treatment and conditioning, transportation and relevant decision-making parameters, in order to determine the overall relevancy of potential management routes depending on given circumstances. (authors)

  1. Exercise during pregnancy and its association with gestational weight gain.

    Science.gov (United States)

    Harris, Shericka T; Liu, Jihong; Wilcox, Sara; Moran, Robert; Gallagher, Alexa

    2015-03-01

    We examined the association between exercise during pregnancy and meeting gestational weight gain recommendations. Data came from the 2009 South Carolina Pregnancy Risk Assessment Monitoring System (n = 856). Women reported their participation in exercise/sports activities before and during pregnancy, including the number of months and types of exercise. We developed an exercise index (EI), the product of the number of months spent in exercise and average metabolic equivalents for specific exercise. The 2009 Institute of Medicine's guideline was used to categorize gestational weight gain into three classes: inadequate, adequate, and excessive. Multinomial logistic regression models were used to adjust for confounders. Over 46 % of women exceeded the recommended weight gain during pregnancy. Nearly one third (31.9 %) of women reported exercising ≥3 times a week at any time during pregnancy. Compared to women who did not report this level of exercise during pregnancy, exercising women were more likely to meet gestational weight gain recommendations (32.7 vs. 18.7 %) and had a lower odds of excessive gestational weight gain [adjusted odds ratio (AOR) 0.43, 95 % confidence interval 0.24-0.78]. Women with an EI above the median value of those women who exercised or women who exercised ≥3 times a week for 6-9 months during pregnancy had lower odds of excessive gestational weight gain (AOR for EI 0.20, 0.08-0.49; AOR for months 0.26, 0.12-0.56, respectively). Our findings support the need to promote or increase exercise during pregnancy to reduce the high proportion of women who are gaining excessive weight.

  2. Large scale permeability test of the granite in the stipa mine and thermal conductivity test. Technical project report No. 2

    International Nuclear Information System (INIS)

    Lundstroem, L.; Stills, H.

    1978-03-01

    The investigated properties of the granite bedrock at Stripa may be summarized as follows: The permeability is very low, 0.4 x 10 -10 m/s, and independent of the pressure gradient. The permeability is reduced by 50 percent at a temperature increase from +10 0 C to +35 0 C. The thermal conductivity was determined in situ to be about 4 W/m 0 C which largely agrees with laboratory determinations. The effective porosity was determined to be 0.012 percent. 12 figs

  3. The off-label use of the Amplatzer muscular VSD occluder for large patent ductus arteriosus: a case report and review.

    Science.gov (United States)

    Cubeddu, Roberto J; Babin, Ivan; Inglessis, Ignacio

    2014-07-01

    A percutaneous approach to the closure of patent ductus arteriosus (PDA) is the preferred procedure in the majority of cases. However, there is little experience with percutaneous closure of unusually large PDA. We report the case of a 28-year-old female with moderate left ventricular dilation and pulmonary hypertension resulting from a large 16 mm PDA. Percutaneous closure was successfully performed using an off-label Amplatzer muscular ventricular septal defect occluder after intravascular ultrasound assessment. Technical challenges, including accurate assessment of defect size and device selection are exemplified along with a comprehensive overview of the available literature.

  4. Weight Gain and Obesity in Infants and Young Children Exposed to Prolonged Antibiotic Prophylaxis.

    Science.gov (United States)

    Edmonson, M Bruce; Eickhoff, Jens C

    2017-02-01

    An association between antibiotic use and excessive weight gain or obesity in healthy infants and young children has been reported, but evidence is inconsistent and based on observational studies of growth in relation to incidental antibiotic exposures. To evaluate whether prolonged antibiotic exposure is associated with weight gain in children participating in a clinical trial of antibiotic prophylaxis to prevent recurrent urinary tract infection. Secondary analysis of data from the Randomized Intervention for Children With Vesicoureteral Reflux Study, a 2-year randomized clinical trial that enrolled participants from 2007 to 2011. All 607 children who were randomized to receive antibiotic (n = 302) or placebo (n = 305) were included. Children with urinary tract anomalies, premature birth, or major comorbidities were excluded from participation. Trimethoprim-sulfamethoxazole or placebo taken orally, once daily, for 2 years. Weight gain as measured by change in weight-for-age z score from baseline to the end-of-study visit at 24 months. Secondary outcomes included weight gain at 6, 12, and 18 months and the prevalence of overweight or obesity at 24 months. Participants had a median age of 12 months (range, 2-71 months) and 558 of 607 (91.9%) were female. Anthropometric data were complete at the 24-month visit for 428 children (214 in the trimethoprim-sulfamethoxazole group and 214 in the placebo group). Weight gain in the trimethoprim-sulfamethoxazole group and the placebo group was similar (mean [SD] change in weight-for-age z score: +0.14 [0.83] and +0.18 [0.85], respectively; difference, -0.04 [95% CI, -0.19 to 0.12]; P = .65). There was no significant difference in weight gain at 6, 12, or 18 months or in the prevalence of overweight or obesity at 24 months (24.8% vs 25.7%; P = .82). Subgroup analyses showed no significant interaction between weight gain effect and age, sex, history of breastfeeding, prior antibiotic use, adherence to study

  5. Megawatt wind turbines gaining momentum

    International Nuclear Information System (INIS)

    Oehlenschlaeger, K.; Madsen, B.T.

    1996-01-01

    Through the short history of the modern wind turbine, electric utilities have made it amply clear that they have held a preference for large scale wind turbines over smaller ones, which is why wind turbine builders through the years have made numerous attempts develop such machines - machines that would meet the technical, aesthetic and economic demands that a customer would require. Considerable effort was put into developing such wind turbines in the early 1980s. There was the U.S. Department of Energy's MOD 1-5 program, which ranged up to 3.2 MW, Denmark's Nibe A and B, 630 kW turbine and the 2 MW Tjaereborg machine, Sweden's Naesudden, 3 MW, and Germany's Growian, 3 MW. Most of these were dismal failures, though some did show the potential of MW technology. (au)

  6. Falsire: CSNI project for fracture analyses of large-scale international reference experiments (Phase 1). Comparison report

    International Nuclear Information System (INIS)

    1994-01-01

    A summary of the recently completed Phase I of the Project for Fracture Analysis of Large-Scale International Reference Experiments (Project FALSIRE) is presented. Project FALSIRE was created by the Fracture Assessment Group (FAG) of Principal Working Group No. 3 (PWG/3) of the OECD/NEA Committee on the Safety of Nuclear Installations (CSNI), formed to evaluate fracture prediction capabilities currently used in safety assessments of nuclear vessel components. The aim of the Project FALSIRE was to assess various fracture methodologies through interpretive analyses of selected large-scale fracture experiments. The six experiments used in Project FALSIRE (performed in the Federal Republic of Germany, Japan, the United Kingdom, and the U.S.A.) were designed to examine various aspects of crack growth in reactor pressure vessel (RPV) steels under pressurized-thermal-shock (PTS) loading conditions. The analysis techniques employed by the participants included engineering and finite-element methods, which were combined with Jr fracture methodology and the French local approach. For each experiment, analysis results provided estimates of variables such as crack growth, crack-mouth-opening displacement, temperature, stress, strain, and applied J and K values. A comparative assessment and discussion of the analysis results are presented; also, the current status of the entire results data base is summarized. Some conclusions concerning predictive capabilities of selected ductile fracture methodologies, as applied to RPVs subjected to PTS loading, are given, and recommendations for future development of fracture methodologies are made

  7. Consultancy on Large-Scale Submerged Aerobic Cultivation Process Design - Final Technical Report: February 1, 2016 -- June 30, 2016

    Energy Technology Data Exchange (ETDEWEB)

    Crater, Jason [Gemomatica, Inc., San Diego, CA (United States); Galleher, Connor [Gemomatica, Inc., San Diego, CA (United States); Lievense, Jeff [Gemomatica, Inc., San Diego, CA (United States)

    2017-05-12

    NREL is developing an advanced aerobic bubble column model using Aspen Custom Modeler (ACM). The objective of this work is to integrate the new fermentor model with existing techno-economic models in Aspen Plus and Excel to establish a new methodology for guiding process design. To assist this effort, NREL has contracted Genomatica to critique and make recommendations for improving NREL's bioreactor model and large scale aerobic bioreactor design for biologically producing lipids at commercial scale. Genomatica has highlighted a few areas for improving the functionality and effectiveness of the model. Genomatica recommends using a compartment model approach with an integrated black-box kinetic model of the production microbe. We also suggest including calculations for stirred tank reactors to extend the models functionality and adaptability for future process designs. Genomatica also suggests making several modifications to NREL's large-scale lipid production process design. The recommended process modifications are based on Genomatica's internal techno-economic assessment experience and are focused primarily on minimizing capital and operating costs. These recommendations include selecting/engineering a thermotolerant yeast strain with lipid excretion; using bubble column fermentors; increasing the size of production fermentors; reducing the number of vessels; employing semi-continuous operation; and recycling cell mass.

  8. Experiment data report for LOFT large-break loss-of-coolant experiment L2-5

    International Nuclear Information System (INIS)

    Bayless, P.D.; Divine, J.M.

    1982-08-01

    Selected pertinent and uninterpreted data from the third nuclear large break loss-of-coolant experiment (Experiment L2-5) conducted in the Loss-of-Fluid Test (LOFT) facility are presented. The LOFT facility is a 50-MW(t) pressurized water reactor (PWR) system with instruments that measure and provide data on the system thermal-hydraulic and nuclear conditions. The operation of the LOFT system is typical of large [approx. 1000 MW(e)] commercial PWR operations. Experiment L2-5 simulated a double-ended offset shear of a cold leg in the primary coolant system. The primary coolant pumps were tripped within 1 s after the break initiation, simulating a loss of site power. Consistent with the loss of power, the starting of the high- and low-pressure injection systems was delayed. The peak fuel rod cladding temperature achieved was 1078 +- 13 K. The emergency core cooling system re-covered the core and quenched the cladding. No evidence of core damage was detected

  9. Self-reported household impacts of large-scale chemical contamination of the public water supply, Charleston, West Virginia, USA.

    Directory of Open Access Journals (Sweden)

    Charles P Schade

    Full Text Available A January 2014 industrial accident contaminated the public water supply of approximately 300,000 homes in and near Charleston, West Virginia (USA with low levels of a strongly-smelling substance consisting principally of 4-methylcyclohexane methanol (MCHM. The ensuing state of emergency closed schools and businesses. Hundreds of people sought medical care for symptoms they related to the incident. We surveyed 498 households by telephone to assess the episode's health and economic impact as well as public perception of risk communication by responsible officials. Thirty two percent of households (159/498 reported someone with illness believed to be related to the chemical spill, chiefly dermatological or gastrointestinal symptoms. Respondents experienced more frequent symptoms of psychological distress during and within 30 days of the emergency than 90 days later. Sixty-seven respondent households (13% had someone miss work because of the crisis, missing a median of 3 days of work. Of 443 households reporting extra expenses due to the crisis, 46% spent less than $100, while 10% spent over $500 (estimated average about $206. More than 80% (401/485 households learned of the spill the same day it occurred. More than 2/3 of households complied fully with "do not use" orders that were issued; only 8% reported drinking water against advice. Household assessments of official communications varied by source, with local officials receiving an average "B" rating, whereas some federal and water company communication received a "D" grade. More than 90% of households obtained safe water from distribution centers or stores during the emergency. We conclude that the spill had major economic impact with substantial numbers of individuals reporting incident-related illnesses and psychological distress. Authorities were successful supplying emergency drinking water, but less so with risk communication.

  10. Self-reported household impacts of large-scale chemical contamination of the public water supply, Charleston, West Virginia, USA.

    Science.gov (United States)

    Schade, Charles P; Wright, Nasandra; Gupta, Rahul; Latif, David A; Jha, Ayan; Robinson, John

    2015-01-01

    A January 2014 industrial accident contaminated the public water supply of approximately 300,000 homes in and near Charleston, West Virginia (USA) with low levels of a strongly-smelling substance consisting principally of 4-methylcyclohexane methanol (MCHM). The ensuing state of emergency closed schools and businesses. Hundreds of people sought medical care for symptoms they related to the incident. We surveyed 498 households by telephone to assess the episode's health and economic impact as well as public perception of risk communication by responsible officials. Thirty two percent of households (159/498) reported someone with illness believed to be related to the chemical spill, chiefly dermatological or gastrointestinal symptoms. Respondents experienced more frequent symptoms of psychological distress during and within 30 days of the emergency than 90 days later. Sixty-seven respondent households (13%) had someone miss work because of the crisis, missing a median of 3 days of work. Of 443 households reporting extra expenses due to the crisis, 46% spent less than $100, while 10% spent over $500 (estimated average about $206). More than 80% (401/485) households learned of the spill the same day it occurred. More than 2/3 of households complied fully with "do not use" orders that were issued; only 8% reported drinking water against advice. Household assessments of official communications varied by source, with local officials receiving an average "B" rating, whereas some federal and water company communication received a "D" grade. More than 90% of households obtained safe water from distribution centers or stores during the emergency. We conclude that the spill had major economic impact with substantial numbers of individuals reporting incident-related illnesses and psychological distress. Authorities were successful supplying emergency drinking water, but less so with risk communication.

  11. Peritonitis secondary to traumatic duodenal laceration in the presence of a large pancreatic pseudocyst: a case report

    OpenAIRE

    Tuboku-Metzger, Vanessa RE; Seenath, Marlon M; Tan, Lam Chin

    2011-01-01

    Abstract Introduction A pancreatic pseudocyst is a common sequela of severe acute pancreatitis. Commonly, it presents with abdominal pain and a mass in the epigastrium several weeks after the acute episode and can be managed conservatively, endoscopically or surgically. We report a patient with a pancreatic pseudocyst awaiting endoscopic therapy who developed a life-threatening complication following a rather innocuous trauma to the abdomen. Case presentation A 23-year-old Asian male student ...

  12. Advanced automated gain adjustments for in-vivo ultrasound imaging

    DEFF Research Database (Denmark)

    Moshavegh, Ramin; Hemmsen, Martin Christian; Martins, Bo

    2015-01-01

    Automatic gain adjustments are necessary on the state-of-the-art ultrasound scanners to obtain optimal scan quality, while reducing the unnecessary user interactions with the scanner. However, when large anechoic regions exist in the scan plane, the sudden and drastic variation of attenuations in....... Wilcoxon signed-rank test was then applied to the ratings provided by radiologists. The average VAS score was highly positive 12.16 (p-value: 2.09 x 10-23) favoring the gain-adjusted scans with the proposed algorithm....

  13. Resection of large invasive pituitary adenomas with individualized approach under neuronavigator guidance:a report of 17 cases

    Directory of Open Access Journals (Sweden)

    Jing-min CHENG

    2011-05-01

    Full Text Available Objective To explore the operative method and therapeutic efficacy of surgical resection of large invasive pituitary adenomas with individualized approach under neuronavigator guidance.Methods Seventeen patients(10 males and 7 females,aged from 22 to 78 years with a mean of 39.2±9.2 years suffering from large invasive pituitary adenoma of higher than Hardy IV grade hospitalized from 2004 to 2009 were involved in the present study.All procedures were performed with the assistance of neuronavigator via individualized pterion approach,subfrontal extradural approach,trans-sphenoidal approach,or combined approach.The dispersedly invasive pituitary adenomas were resected under the guidance of neuronavigator by fully utilizing the natural anatomical cleavages.All the patients received follow-up CT scanning 3 days after operation,MRI scanning 1 to 3 months after operation,and clinical follow-up ranged from 6 to 72 months.The resection extent and outcome were assessed by imaging examination and clinical results.Results Total tumor removal was achieved in 15 cases,subtotal removal in 1 case,and extensive partial removal in 1 case.The visual impairment and headache were ameliorated in most cases,but in 1 patient they were worsened.Transient diabetes insipidus occurred in 8 cases,electrolyte disturbances were observed in 2 cases,leakage of cerebrospinal fluid appeared in 2 cases,hyposmia in 2 cases,visual impairment aggravated in 1 case,oculomotor nerve and abducens nerve paralysis on the operative side in 1 case,epidural hematoma in occipital and parietal regions in 1 case.No patient died during the follow-up period.Conclusions Individualized surgical approach designed according to the growth direction of tumor under neuronavigator guidance is helpful for the operators to identify the vessels and nerves in the operative field distinctly during the operation,thus the total removal rate is improved,safely of the operation to remove large invasive pituitary

  14. Site Release Report for C-Well Pipeline, UE-25 Large Rocks Test Site, and 29 GSF Test Pits

    International Nuclear Information System (INIS)

    K.E. Rasmuson

    2002-01-01

    The U.S. Department of Energy has implemented a program to reclaim lands disturbed by site characterization at Yucca Mountain. Long term goals of the program are to re-establish processes on disturbed sites that will lead to self-sustaining plant communities. The Biological Opinion for Yucca Mountain Site Characterization Studies required that the U.S. Department of Energy develop a Reclamation Standards and Monitoring Plan to evaluate the success of reclamation efforts. According to the Reclamation Standards and Monitoring Plan, reclaimed sites will be monitored periodically, remediated if necessary, and eventually compared to an appropriate reference area to determine whether reclamation goals have been achieved and the site can be released from further monitoring. Plant cover, density, and species richness (success parameters) on reclaimed sites are compared to 60 percent of the values (success criteria) for the same parameters on the reference area. Small sites (less than 0.1 ha) are evaluated for release using qualitative methods while large sites (greater than 0.1 ha) are evaluated using quantitative methods. In the summer of 2000, 31 small sites reclaimed in 1993 and 1994 were evaluated for reclamation success and potential release from further monitoring. Plant density, cover, and species richness were estimated on the C-Well Pipeline, UE-25 Large Rocks test site, and 29 ground surface facility test pits. Evidence of erosion, reproduction and natural recruitment, exotic species abundance, and animal use (key attributes) also were recorded for each site and used in success evaluations. The C-Well Pipeline and ground surface facility test pits were located in a ''Larrea tridentata - Ephedra nevadensis'' vegetation association while the UE-25 Large Rocks test site was located in an area dominated by ''Coleogyne ramosissima and Ephedra nevadensis''. Reference areas in the same vegetation associations with similar slope and aspect were chosen for comparison to

  15. Site Release Reports for C-Well Pipeline, UE-25 Large Rocks Test Site, and 29 GSF Test Pits

    Energy Technology Data Exchange (ETDEWEB)

    K.E. Rasmuson

    2002-04-02

    The U.S. Department of Energy has implemented a program to reclaim lands disturbed by site characterization at Yucca Mountain. Long term goals of the program are to re-establish processes on disturbed sites that will lead to self-sustaining plant communities. The Biological Opinion for Yucca Mountain Site Characterization Studies required that the U.S. Department of Energy develop a Reclamation Standards and Monitoring Plan to evaluate the success of reclamation efforts. According to the Reclamation Standards and Monitoring Plan, reclaimed sites will be monitored periodically, remediated if necessary, and eventually compared to an appropriate reference area to determine whether reclamation goals have been achieved and the site can be released from further monitoring. Plant cover, density, and species richness (success parameters) on reclaimed sites are compared to 60 percent of the values (success criteria) for the same parameters on the reference area. Small sites (less than 0.1 ha) are evaluated for release using qualitative methods while large sites (greater than 0.1 ha) are evaluated using quantitative methods. In the summer of 2000, 31 small sites reclaimed in 1993 and 1994 were evaluated for reclamation success and potential release from further monitoring. Plant density, cover, and species richness were estimated on the C-Well Pipeline, UE-25 Large Rocks test site, and 29 ground surface facility test pits. Evidence of erosion, reproduction and natural recruitment, exotic species abundance, and animal use (key attributes) also were recorded for each site and used in success evaluations. The C-Well Pipeline and ground surface facility test pits were located in a ''Larrea tridentata - Ephedra nevadensis'' vegetation association while the UE-25 Large Rocks test site was located in an area dominated by ''Coleogyne ramosissima and Ephedra nevadensis''. Reference areas in the same vegetation associations with similar slope

  16. Component separation of abdominal wall with intraoperative botulinum A presents satisfactory outcomes in large incisional hernias: a case report.

    Science.gov (United States)

    Oliveira, Lucas Torres; Essu, Felipe Futema; de Mesquita, Gustavo Heluani Antunes; Jardim, Yuri Justi; Iuamoto, Leandro Ryuchi; Suguita, Fábio Yuji; Martines, Diego Ramos; Nii, Fernanda; Waisberg, Daniel Reis; Meyer, Alberto; Andraus, Wellington; D'Albuquerque, Luiz Augusto Carneiro

    2017-01-01

    Transplantation patients have a series of associated risk factors that make appearance of incisional hernia (IH) more likely. A number of aspects of the closure of large defects remain controversial. In this manuscript, we present the repair of a large IH following liver transplantation through the technique of posterior components separation combined with the anterior, together with the intraoperative use of botulinum toxin A and the placement of mesh. As a secondary objective, we analyze the incidence of IH following liver transplantation in our service. Between the years 2013 and 2016, 247 patients underwent liver transplantation in the Liver Transplantation Service at the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil. We analyzed the incidence of IH in these patients. One of these cases operated in March 2017 presented a defect in the abdominal wall of 22×16.6×6.4cm in the median and paramedian regions. We present the details of this innovative surgical technique. The total operating time was 470min. During the postoperative phase the patient presented ileus paralysis, without systemic repercussions. Resumption of an oral diet on the fifth postoperative day, without incident. Hospital discharge occurred on the 12th postoperative day, with outpatient follow up. In our service, the incidence of incisional hernias following liver transplantation is 14.5%. We described a successful approach for selected patient group for whom there is no established standard treatment. Given the complexity of such cases, however, more studies are necessary. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  17. Large-scale wind energy and birds in Friesland: A survey of the possible hindrance for birds of the project Windstreek: Environmental Effect Report Windstreek, Base report A

    International Nuclear Information System (INIS)

    Van den Bergh, L.M.J.; Spaans, A.L.

    1994-01-01

    For several alternative sites in the Dutch province Friesland, where it is planned to install 500 kW and 1 MW wind turbines on a large scale (the Windstreek project), the possible hindrance for breeding birds, stopping birds and migratory birds has been investigated. First an overview is given of basic data from the literature and experts in the field with regard to the possible hindrances for birds and the situation of the birds in the areas considered. Next, several criteria are used to determine which locations are the most suitable sites for placing the wind turbines. For the 500 kW wind turbines (worst case) the suitability differs strongly per site. The variation is the largest for the option of decentralized sites. Realization of 200 MW large-scale generated wind power is the least unfavourable option, regarding the effects on birds, by means of decentralized sites. The super-structure option Afsluitdijk-Waddenkust and the Project Memorandum alternative are for that matter the least favourable options. The combined alternative and the super-structure Middelzeetrechter take the in-between position. The 1MW variants of the alternatives score better than the similar 500 kW options. The hindrance for birds can be reduced further by applying two-bladed rotors instead of three-bladed rotors and to adjust the site. 20 figs., 9 tabs., 2 appendices, 42 refs

  18. Thermoregulation and temperature relations of alligators and other large ectotherms inhabiting thermally stressed habitats. Annual progress report, 1 July 1976--30 September 1977

    International Nuclear Information System (INIS)

    Spotila, J.R.

    1977-06-01

    Progress is reported on studies of the biophysical and thermal relationships between large ectotherms and their aquatic environment. Data are reported from laboratory and field studies on alligators, turtles, and fish. Mathematical models of the effect of body size and physical characteristics on temperature regulation of ectotherms and of thermal stress in aquatic organisms were developed. Results are included of field studies on the physiological and behavioral adjustments of turtles in response to changes in water temperature produced by thermal effluents in PAR Pond at the Savannah River Ecology Laboratory

  19. A Newborn with a Large Umbilical Cord Pseudocyst with Hemangioma: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    İbrahim Akkoyun

    2012-08-01

    Full Text Available Umbilical cord pseudocysts in a newborn are very rare. They may be associated with patent urachus and hemangioma. Generally, they are localized in a particular section of the cord. Urachal or vitelline duct cysts, teratoma, omphalocele, umbilical cord hernia and hematoma are considered in differential diagnosis. In this case report, we discussed the clinicopathological findings of a pseudocyst with hemangioma involving the entire cord in a newborn, and in particular the confusing conditions related to the excision of the umbilical cord.

  20. Experience gained in gamma spectroscopy

    International Nuclear Information System (INIS)

    Jeanmaire, L.

    1960-01-01

    There are two types of method which make it possible to estimate the internal contamination of individuals. On the one hand these are the indirect techniques based on measurements of the excreted products, on the other there are the direct techniques in which attempts are made to measure directly the radio-activity existing in the organism. We propose to give a few of the results obtained by the direct method using equipment built by the Commissariat a l'Energie Atomique. The apparatus consists of a γ spectrometer. It includes: 1) A crystal of sodium iodide 20 cm in diameter and 10 cm high. The large size of this crystal ensures a good sensitivity and makes it possible to carry out rapid measurements. 2) A 25 channel type SAE 25 selector which classifies the pulses according to their amplitude. It is therefore possible to distinguish between γ rays of varying energy. 3) A comparatively very light radiation protection, consisting of only 5 cm thickness of lead which diminishes the ambient γ ray intensity to a sufficient level for the majority of the measurements. A certain collimation is thus obtained which makes it possible to localise the source approximately and to reduce the undesirable effects of external contamination. (author) [fr

  1. Influences of finite gain bandwidth on pulse propagation in parabolic fiber amplifiers with distributed gain profiles

    International Nuclear Information System (INIS)

    Zhao Jia-Sheng; Li Pan; Chen Xiao-Dong; Feng Su-Juan; Mao Qing-He

    2012-01-01

    The evolutions of the pulses propagating in decreasing and increasing gain distributed fiber amplifiers with finite gain bandwidths are investigated by simulations with the nonlinear Schrödinger equation. The results show that the parabolic pulse propagations in both the decreasing and the increasing gain amplifiers are restricted by the finite gain bandwidth. For a given input pulse, by choosing a small initial gain coefficient and gain variation rate, the whole gain for the pulse amplification limited by the gain bandwidth may be higher, which is helpful for the enhancement of the output linearly chirped pulse energy. Compared to the decreasing gain distributed fiber amplifier, the increasing gain distributed amplifier may be more conducive to suppress the pulse spectral broadening and increase the critical amplifier length for achieving a larger output linearly chirped pulse energy

  2. Energy Gaining Windows for Residental Buildings

    DEFF Research Database (Denmark)

    Kragh, Jesper; Laustsen, Jacob Birck; Svendsen, Svend

    2008-01-01

    This paper presents some of the research done during the last 8 years at the Technical University of Denmark developing improved low-energy window solutions. The focus has been on maximizing the net energy gain of windows for residential buildings. The net energy gain of windows is the solar gain...... minus the heat loss integrated over the heating season. It is assumed that in northern cold climates all of the solar gain during the heating season can be utilized for space heating. Problems with overheating in the summer period must be solved with overhang or moveable solar shading devices. Two...... and longer durability of the window. The glazing in these fiber reinforced polyester windows is both unsealed and sealed triple glazing units. To increase the net energy gain slim frame profiles have been developed to increase the glazing area and thereby the solar gain. The challenge when developing slim...

  3. Fetal Programming of Obesity: Maternal Obesity and Excessive Weight Gain

    Directory of Open Access Journals (Sweden)

    Seray Kabaran

    2014-10-01

    Full Text Available The prevalence of obesity is an increasing health problem throughout the world. Maternal pre-pregnancy weight, maternal nutrition and maternal weight gain are among the factors that can cause childhood obesity. Both maternal obesity and excessive weight gain increase the risks of excessive fetal weight gain and high birth weight. Rapid weight gain during fetal period leads to changes in the newborn body composition. Specifically, the increase in body fat ratio in the early periods is associated with an increased risk of obesity in the later periods. It was reported that over-nutrition during fetal period could cause excessive food intake during postpartum period as a result of metabolic programming. By influencing the fetal metabolism and tissue development, maternal obesity and excessive weight gain change the amounts of nutrients and metabolites that pass to the fetus, thus causing excessive fetal weight gain which in turn increases the risk of obesity. Fetal over-nutrition and excessive weight gain cause permanent metabolic and physiologic changes in developing organs. While mechanisms that affect these organs are not fully understood, it is thought that the changes may occur as a result of the changes in fetal energy metabolism, appetite control, neuroendocrine functions, adipose tissue mass, epigenetic mechanisms and gene expression. In this review article, the effects of maternal body weight and weight gain on fetal development, newborn birth weight and risk of obesity were evaluated, and additionally potential mechanisms that can explain the effects of fetal over-nutrition on the risk of obesity were investigated [TAF Prev Med Bull 2014; 13(5.000: 427-434

  4. Market Efficiency Analysis at the Stockholm Stock Exchange: Measuring Intraday Stock Price Performance around Interim Reports of the OMXS30 Large Cap Stocks - An Event Study Approach

    OpenAIRE

    Tames Blanco, Juan Marcelo; Nsiah, Samuel Osei

    2010-01-01

    The purpose of this thesis is to perform event studies that determine the level of efficiency of twenty-two large cap stocks from the OMXS30 Index. Under the event study methodology, analysts’ expectations, the standard Capital Asset Pricing Model and a set of parametric tests are implemented. As a result, significant evidence is found on the existence of intraday abnormal returns at the exact moment of an interim report publication. However, further evidence on market corrections state effic...

  5. Report on a workshop on the application of thermoluminescence dosimetry to large scale individual monitoring, Ispra, 11-13 September 1985

    International Nuclear Information System (INIS)

    Barthe, J.R.; Christensen, P.; Driscoll, C.M.H.; Marshall, T.O.; Harvey, J.R.; Julius, H.W.; Marshall, M.; Oberhoffer, M.

    1987-01-01

    The workshop was held for the benefit of those actually involved in the operation of large scale automatic thermoluminescence dosimetry systems. It was organised around three overall themes subdivided into 13 subject headings: External constraints: User requirements, Quantities and Units, Legal requirements, Testing, Intercomparisons; Dosimetry systems: Materials, Dosemeter design, Reading systems, Annealing procedures, Rogue readings; Management: Distribution and organisation, Reporting and record keeping, Financial aspects. (author)

  6. Report on 14 Large Whales That Died due to Ship Strikes off the Coast of Sri Lanka, 2010–2014

    Directory of Open Access Journals (Sweden)

    Ranil P. Nanayakkara

    2017-01-01

    Full Text Available The greatest threat to cetaceans in Sri Lankan waters was considered to be the direct take of small- and medium-sized cetaceans using harpoons and/or as bycatch until recently. However, ship strikes have probably been occurring for years but have not been recognized for what they were. For the current study, only animals with visible and prominent injuries related to collisions were evaluated. Data gathered between 2010 and 2014 included the species, morphometry, location, and date; tissue samples were collected for genetic analysis. When possible, a complete necropsy was conducted; otherwise, partial necropsies were conducted. The study confirmed 14 reports of ship strikes between whales and vessels out of all the strandings reported from 2010 to 2014. Most strikes (n=09, 64% involved blue whales (Balaenoptera musculus, although three other species were also documented, one Cuvier’s beaked whale, two great sperm whales, and one Bryde’s whale, as well as one unidentified baleen whale. Collision hotspots such as the southern waters of Sri Lanka are areas that warrant special attention in the form of vessel routing measures or speed limits, research on cetacean ecology, distribution, daily and seasonal movements, public service announcements, increased law enforcement presence, and other measures.

  7. Inter-observer reproducibility in reporting on renal drainage in children with hydronephrosis: a large collaborative study

    International Nuclear Information System (INIS)

    Tondeur, Marianne; Piepsz, Amy; De Palma, Diego; Roca, Isabel; Ham, Hamphrey

    2008-01-01

    The goal of this study was to evaluate the inter-observer reproducibility in reporting on renal drainage obtained during 99m Tc MAG3 renography in children, when already processed data are offered to the observers. Because web site facilities were used for communication, 57 observers from five continents participated in the study. Twenty-three renograms, including furosemide stimulation and posterect postmicturition views, covering various patterns of drainage, were submitted to the observers. Images, curves and quantitative parameters were provided. Good or almost good drainage, partial drainage and poor or no drainage were the three possible responses for each kidney. An important bias was observed among the observers, some of them more systematically reporting the drainage as being good, while others had a general tendency to consider the drainage as poor. This resulted in rather poor inter-observer reproducibility, as for more than half of the kidneys, less than 80% of the observers agreed on one of the three responses. Analysis of the individual cases identified some obvious causes of discrepancy: the absence of a clear limit between partial and good or almost good drainage, the fact of including or neglecting the effect of micturition and change of patient's position, the underestimation of drainage in the case of a flat renographic curve, and the difficulties of interpretation in the case of a small, not well functioning kidney. There is an urgent need for better standardisation in estimating the quality of drainage. (orig.)

  8. A Large Asymptomatic Thoracic Spine Schwannoma Detected Incidentally by {sup 18}F-FDG PET/CT: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Bahk, Yong Whee [Seoul Sungae Hospital, Seoul (Korea, Republic of); Yoo, Ie Ryung [Catholic University Medical School Hospital, Seoul (Korea, Republic of)

    2008-10-15

    Schwannoma is not a rare tumor occurring anywhere where sheathed nerve fibers present. However the spinal involvement has been noted to be uncommon. The use of PET in the diagnosis of spinal schwannomas seemed to have only sporadically been reported and standardized uptake values (SUV) measured in peripheral nerves schwannomas varied according to cellularity. Most reported spinal schwannoms were symptomatic and relatively hypometabolic but ours differed in that despite considerable compression of the spinal cord it did not produce clinical symptoms or signs and had a relatively high FDG uptake value. The spine was operated. On opening a 1.0x1.5 cm tumor was found to be encapsulated and located in the right posterolateral aspect of the intradural space at the 4th thoracic spine level. It was completely resected along with the rootlet from which the tumor seemed to have originated not damaging the cord or causing bleeding. The spinal medulla compressed by and adherent to the tumor was decompressed and released following arachnoid adhesiolysis. The hospital stay was uneventful. Patient was discharged and is well and fine without complication eight months after surgery.

  9. Inter-observer reproducibility in reporting on renal drainage in children with hydronephrosis: a large collaborative study

    Energy Technology Data Exchange (ETDEWEB)

    Tondeur, Marianne; Piepsz, Amy [CHU Saint-Pierre, Departement des Radio-Isotopes, Brussels (Belgium); De Palma, Diego [Ospedale di Circolo, Nuclear Medicine, Varese (Italy); Roca, Isabel [Vall d' Hebron Hospital, Nuclear Medicine, Barcelona (Spain); Ham, Hamphrey [University Hospital, Department Nuclear Medicine, Ghent (Belgium)

    2008-03-15

    The goal of this study was to evaluate the inter-observer reproducibility in reporting on renal drainage obtained during {sup 99m}Tc MAG3 renography in children, when already processed data are offered to the observers. Because web site facilities were used for communication, 57 observers from five continents participated in the study. Twenty-three renograms, including furosemide stimulation and posterect postmicturition views, covering various patterns of drainage, were submitted to the observers. Images, curves and quantitative parameters were provided. Good or almost good drainage, partial drainage and poor or no drainage were the three possible responses for each kidney. An important bias was observed among the observers, some of them more systematically reporting the drainage as being good, while others had a general tendency to consider the drainage as poor. This resulted in rather poor inter-observer reproducibility, as for more than half of the kidneys, less than 80% of the observers agreed on one of the three responses. Analysis of the individual cases identified some obvious causes of discrepancy: the absence of a clear limit between partial and good or almost good drainage, the fact of including or neglecting the effect of micturition and change of patient's position, the underestimation of drainage in the case of a flat renographic curve, and the difficulties of interpretation in the case of a small, not well functioning kidney. There is an urgent need for better standardisation in estimating the quality of drainage. (orig.)

  10. How large must an epileptic focus be to cause an electrographic status epilepticus--a case report.

    Science.gov (United States)

    Fauser, Susanne; Schulze-Bonhage, Andreas

    2004-10-01

    Based on experimental data from animal studies different theories regarding the size of an epileptic focus have been postulated which range from single pacemaker cells to extended neuronal networks. We report a case which gives further information about the size of a human epileptic focus which can trigger manifest epileptic seizures. We report a 22-year-old man with medically refractory temporal lobe epilepsy. This patient suffered from brief complex partial seizures and frequent epigastric auras. To differentiate a mesiotemporal from a temporolateral seizure origin the patient was implanted with a 10 contact depth electrode from a posterior approach into the right hippocampus, and additional temporobasal/temporolateral subdural strip electrodes. Depth recordings revealed an electrographic status with continuous rhythmic sharp wave activity (1 Hz), the field of which was confined to a diameter of less than 1 cm in the anterior hippocampus, whereas temporobasal subdural strip electrodes did not display this activity. Periodically, spread of this activity occurred to the amygdala, to the posterior part of the hippocampus, and less often to the temporobasal cortex. Most seizure patterns remained subclinical, few of them became symptomatic as partial seizures. This case demonstrates that a hippocampal epileptic focus causing electrographic focal status epilepticus may be limited to a volume of less than 1 cm in diameter. This observation is discussed with regard to implantation strategies and to possible superselective resective or modulatory approaches in the treatment of such limited epileptogenic areas.

  11. European wind integration study (EWIS). Towards a successful integration of large scale wind power into European electricity grids. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Winter, W.

    2010-03-15

    Large capacities of wind generators have already been installed and are operating in Germany (26GW) and Spain (16GW). Installations which are as significant in terms of proportion to system size are also established in Denmark (3.3GW), the All Island Power System of Ireland and Northern Ireland (1.5GW), and Portugal (3.4GW). Many other countries expect significant growth in wind generation such that the total currently installed capacity in Europe of 68GW is expected to at least double by 2015. Yet further increases can be expected in order to achieve Europe's 2020 targets for renewable energy. The scale of this development poses big challenges for wind generation developers in terms of obtaining suitable sites, delivering large construction projects, and financing the associated investments from their operations. Such developments also impact the networks and it was to address the immediate transmission related challenges that the European Wind Integration Study (EWIS) was initiated by Transmission System Operators (TSOs) with the objective of ensuring the most effective integration of large scale wind generation into Europe's transmission networks and electricity system. The challenges anticipated and addressed include: 1) How to efficiently accommodate wind generation when markets and transmission access arrangements have evolved for the needs of traditional controllable generation. 2) How to ensure supplies remain secure as wind varies (establishing the required backup/reserves for low wind days and wind forecast errors as well as managing network congestion in windy conditions). 3) How to maintain the quality and reliability of supplies given the new generation characteristics. 4) How to achieve efficient network costs by suitable design and operation of network connections, the deeper infrastructure including offshore connections, and crossborder interconnections. EWIS has focused on the immediate network related challenges by analysing detailed

  12. Informant Agreement in Treatment Gains for Child Anxiety

    Science.gov (United States)

    Benjamin, Courtney L.; Puleo, Connor M.; Kendall, Philip C.

    2011-01-01

    The present study examined multiple informant agreement in reports of treatment gains in a sample of children (M age = 10.27) treated for social phobia, generalized anxiety disorder, and separation anxiety disorder. Mothers and fathers agreed on their child's improvement, and parents and children also generally agreed on the child's improvement.…

  13. Measurement of Antenna Bore-Sight Gain

    Science.gov (United States)

    Fortinberry, Jarrod; Shumpert, Thomas H.

    2016-01-01

    The absolute or free-field gain of a simple antenna can be approximated using standard antenna theory formulae or for a more accurate prediction, numerical methods may be employed to solve for antenna parameters including gain. Both of these methods will result in relatively reasonable estimates but in practice antenna gain is usually verified and documented via measurements and calibration. In this paper, a relatively simple and low-cost, yet effective means of determining the bore-sight free-field gain of a VHF/UHF antenna is proposed by using the Brewster angle relationship.

  14. Directional amplifier in an optomechanical system with optical gain

    Science.gov (United States)

    Jiang, Cheng; Song, L. N.; Li, Yong

    2018-05-01

    Directional amplifiers are crucial nonreciprocal devices in both classical and quantum information processing. Here we propose a scheme for realizing a directional amplifier between optical and microwave fields based on an optomechanical system with optical gain, where an active optical cavity and two passive microwave cavities are coupled to a common mechanical resonator via radiation pressure. The two passive cavities are coupled via hopping interaction to facilitate the directional amplification between the active and passive cavities. We obtain the condition of achieving optical directional amplification and find that the direction of amplification can be controlled by the phase differences between the effective optomechanical couplings. The effects of the gain rate of the active cavity and the effective coupling strengths on the maximum gain of the amplifier are discussed. We show that the noise added to this amplifier can be greatly suppressed in the large cooperativity limit.

  15. A Large Hadron Electron Collider at CERN: Report on the Physics and Design Concepts for Machine and Detector

    CERN Document Server

    Abelleira Fernandez, J.L.; Akay, A.N.; Aksakal, H.; Albacete, J.L.; Alekhin, S.; Allport, P.; Andreev, V.; Appleby, R.B.; Arikan, E.; Armesto, N.; Azuelos, G.; Bai, M.; Barber, D.; Bartels, J.; Behnke, O.; Behr, J.; Belyaev, A.S.; Ben-Zvi, I.; Bernard, N.; Bertolucci, S.; Bettoni, S.; Biswal, S.; Blumlein, J.; Bottcher, H.; Bogacz, A.; Bracco, C.; Brandt, G.; Braun, H.; Brodsky, S.; Buning, O.; Bulyak, E.; Buniatyan, A.; Burkhardt, H.; Cakir, I.T.; Cakir, O.; Calaga, R.; Cetinkaya, V.; Ciapala, E.; Ciftci, R.; Ciftci, A.K.; Cole, B.A.; Collins, J.C.; Dadoun, O.; Dainton, J.; De Roeck, A.; d'Enterria, D.; Dudarev, A.; Eide, A.; Enberg, R.; Eroglu, E.; Eskola, K.J.; Favart, L.; Fitterer, M.; Forte, S.; Gaddi, A.; Gambino, P.; Garcia Morales, H.; Gehrmann, T.; Gladkikh, P.; Glasman, C.; Godbole, R.; Goddard, B.; Greenshaw, T.; Guffanti, A.; Guzey, V.; Gwenlan, C.; Han, T.; Hao, Y.; Haug, F.; Herr, W.; Herve, A.; Holzer, B.J.; Ishitsuka, M.; Jacquet, M.; Jeanneret, B.; Jimenez, J.M.; Jowett, J.M.; Jung, H.; Karadeniz, H.; Kayran, D.; Kilic, A.; Kimura, K.; Klein, M.; Klein, U.; Kluge, T.; Kocak, F.; Korostelev, M.; Kosmicki, A.; Kostka, P.; Kowalski, H.; Kramer, G.; Kuchler, D.; Kuze, M.; Lappi, T.; Laycock, P.; Levichev, E.; Levonian, S.; Litvinenko, V.N.; Lombardi, A.; Maeda, J.; Marquet, C.; Mellado, B.; Mess, K.H.; Milanese, A.; Moch, S.; Morozov, I.I.; Muttoni, Y.; Myers, S.; Nandi, S.; Nergiz, Z.; Newman, P.R.; Omori, T.; Osborne, J.; Paoloni, E.; Papaphilippou, Y.; Pascaud, C.; Paukkunen, H.; Perez, E.; Pieloni, T.; Pilicer, E.; Pire, B.; Placakyte, R.; Polini, A.; Ptitsyn, V.; Pupkov, Y.; Radescu, V.; Raychaudhuri, S.; Rinol, L.; Rohini, R.; Rojo, J.; Russenschuck, S.; Sahin, M.; Salgado, C.A.; Sampei, K.; Sassot, R.; Sauvan, E.; Schneekloth, U.; Schorner-Sadenius, T.; Schulte, D.; Senol, A.; Seryi, A.; Sievers, P.; Skrinsky, A.N.; Smith, W.; Spiesberger, H.; Stasto, A.M.; Strikman, M.; Sullivan, M.; Sultansoy, S.; Sun, Y.P.; Surrow, B.; Szymanowski, L.; Taels, P.; Tapan, I.; Tasci, T.; Tassi, E.; Ten Kate, H.; Terron, J.; Thiesen, H.; Thompson, L.; Tokushuku, K.; Tomas Garcia, R.; Tommasini, D.; Trbojevic, D.; Tsoupas, N.; Tuckmantel, J.; Turkoz, S.; Trinh, T.N.; Tywoniuk, K.; Unel, G.; Urakawa, J.; VanMechelen, P.; Variola, A.; Veness, R.; Vivoli, A.; Vobly, P.; Wagner, J.; Wallny, R.; Wallon, S.; Watt, G.; Weiss, C.; Wiedemann, U.A.; Wienands, U.; Willeke, F.; Xiao, B.W.; Yakimenko, V.; Zarnecki, A.F.; Zhang, Z.; Zimmermann, F.; Zlebcik, R.; Zomer, F.

    2012-01-01

    The physics programme and the design are described of a new collider for particle and nuclear physics, the Large Hadron Electron Collider (LHeC), in which a newly built electron beam of 60 GeV, up to possibly 140 GeV, energy collides with the intense hadron beams of the LHC. Compared to HERA, the kinematic range covered is extended by a factor of twenty in the negative four-momentum squared, $Q^2$, and in the inverse Bjorken $x$, while with the design luminosity of $10^{33}$ cm$^{-2}$s$^{-1}$ the LHeC is projected to exceed the integrated HERA luminosity by two orders of magnitude. The physics programme is devoted to an exploration of the energy frontier, complementing the LHC and its discovery potential for physics beyond the Standard Model with high precision deep inelastic scattering measurements. These are designed to investigate a variety of fundamental questions in strong and electroweak interactions. The physics programme also includes electron-deuteron and electron-ion scattering in a $(Q^2, 1/x)$ ran...

  16. A Large Cystic Variant of Gastro-intestinal Stromal Tumour arising from the Jejunum: A Case Report.

    Science.gov (United States)

    Shaikh, Salman Tehran; Upwanshi, Manish Harinarayan; Shetty, Tilakdas S; Ghetla, Smruti R; Gheewala, Hussain

    2015-04-01

    Gastrointestinal stromal tumours (GISTs) represent a mesenchymal neoplasm arising from the interstitial cells of cajal occurring mainly in the gastrointestinal tract. Here, we present a case of a large GIST arising from the jejunum with cystic presentation unlike the usual presentation as a solid mass. A 50-year-old male patient came with complaint of a painless mobile lump in abdomen of approximately 25 cm in size which had gradually increased over two years. Clinically mesenteric cyst was suspected. Intra-operatively the mass was a 30x25 cm cyst with approximately 2500 ml serous fluid present inside it arising from the anti-mesenteric border of the jejunum, adherent to the jejunum, appendix and the dome of the bladder. The fluid was aspirated and the mass excised along with resection of the involved jejunal segment and appendectomy was done. Diagnosis was confirmed on immunohistochemistry study. Imatinib Mesylate 400 mg OD was started as adjuvant therapy in view of the high risk of metastasis.

  17. A patient with myasthenia gravis and a large arachnoid cyst - report of a case.

    Science.gov (United States)

    Bucuk, Mira; Gasparovic, Iva; Sonnenschein, Ivan; Perkovic, Olivio

    2017-05-01

    Myasthenia gravis is a chronic autoimmune disease characterized by weakening of voluntary muscles during the day and a marked restitution of function during the night and after rest. The symptoms may worsen over days or weeks, sometimes even in a few hours, and are usually well controlled by appropriate therapy. Arachnoid cysts are congenital or acquired deformities of the arachnoid membrane and are usually too small to cause distinct clinical symptomatology. We describe a case of a 76-year-old myasthenia gravis patient with an arachnoid cyst. To the best of our knowledge this is the first reported case of these two comorbidities together.

  18. Report of the panel on the use of depleted uranium alloys for large caliber long rod kinetic energy penetrators

    International Nuclear Information System (INIS)

    Sandstrom, D.J.; Jessen, N.; Loewenstein, P.; Weirick, L.

    1980-01-01

    In early 1977 the National Materials Advisory Board, an operating unit in the Commission on Sociotechnical Systems of the National Research Council, NAS/NAE, formed a study committee on High Density Materials for Kinetic Energy Penetrators. The Specific objectives of the Committee were defined as follows. Assess the potential of two materials for use in kinetic energy penetrators, including such factors as: (a) properties (as applied to this application: strength, toughness, and dynamic behavior); (b) uniformity, reliability and reproducibility; (c) deterioration in storage; (d) production capability; (e) ecological impact; (f) quality assurance; (g) availability, and (h) cost. The Committee was divided into two Panels; one panel devoted to the study of tungsten alloys and the other devoted to the study of depleted uranium alloys for use in Kinetic energy penetrators. This report represents the findings and recommendation of the Panel on Uranium

  19. Patient-reported outcome measures for patients with cerebral aneurysms acquired via social media: data from a large nationwide sample.

    Science.gov (United States)

    Chen, Michael; Mangubat, Erwin; Ouyang, Bichun

    2016-01-01

    With greater survival rates, patient-reported outcome measures (PROMs) among survivors of ruptured cerebral aneurysm should be an increasing concern among neurointerventionalists. Prior studies were limited in scale and generalizability. Our study aims were to (1) evaluate the validity of cerebral aneurysm PROMs obtained from social media; (2) determine the persistence of PROMs over time; and (3) determine what PROMs still exist in those with no physical impairments. By engaging national brain aneurysm support groups and using an online questionnaire modeled after the generic EQ-5D instrument, we asked respondents to classify their health in five dimensions including mobility, self-care, usual activities, pain/discomfort, and anxiety/depression using a 3-point Likert scale. In 2 months we received 604 responses from 46 states in the USA. Our cohort of ruptured aneurysm respondents reported PROMs similar to previously published series. Over time, headache and anxiety improved while depression, level of exercise, and return to work remained unchanged. We found that memory worsened after 2 years. Among those without any physical impairment, rates of 20.6%, 14.9%, 12.6%, and 23% were seen for significant headaches, significant memory loss, significant depression, and sense of life being negatively affected, respectively. Despite this novel study design, we obtained results comparable to prior studies. These results suggest that many patients with ruptured cerebral aneurysms, regardless of whether they are >2 years after the event and/or free of physical impairment, struggle with a poor quality of life. The latency, scale, and low cost of this study design may accelerate future cerebral aneurysm PROM research. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  20. Developing technology for large-scale production of forest chips. Wood Energy Technology Programme 1999-2003. Interim report

    International Nuclear Information System (INIS)

    Hakkila, P.

    2003-01-01

    Finland is enhancing its use of renewable sources in energy production. From the 1995 level, the use of renewable energy is to be increased by 50 % by 2010, and 100 % by 2025. Wood-based fuels will play a leading role in this development. The main source of wood-based fuels is processing residues from the forest industries. However, as all processing residues are already in use, an increase is possible only as far as the capacity and wood consumption of the forest industries grow. Energy policy affects the production and availability of processing residues only indirectly. Another large source of wood-based energy is forest fuels, consisting of traditional firewood and chips comminuted from low-quality biomass. It is estimated that the reserve of technically harvest-able forest biomass is 10-16 Mm' annually, when no specific cost limit is applied. This corresponds to 2-3 Mtoe or 6-9 % of the present consumption of primary energy in Finland. How much of this re-serve it will actually be possible to harvest and utilize depends on the cost competitiveness of forest chips against alternative sources of energy. A goal of Finnish energy and climate strategies is to use 5 Mm' forest chips annually by 2010. The use of wood fuels is being promoted by means of taxation, investment aid and support for chip production from young forests. Furthermore, research and development is being supported in order to create techno-economic conditions for the competitive production of forest chips. In 1999, the National Technology Agency Tekes established the five-year Wood Energy Technology Programme to stimulate the development of efficient systems for the large-scale production of forest chips. Key tar-gets are competitive costs, reliable supply and good quality chips. The two guiding principles of the programme are: (1) close cooperation between researchers and practitioners and (2) to apply research and development to the practical applications and commercialization. As of November

  1. Weight gain following treatment of hyperthyroidism.

    Science.gov (United States)

    Dale, J; Daykin, J; Holder, R; Sheppard, M C; Franklyn, J A

    2001-08-01

    Patients frequently express concern that treating hyperthyroidism will lead to excessive weight gain. This study aimed to determine the extent of, and risk factors for, weight gain in an unselected group of hyperthyroid patients. We investigated 162 consecutive hyperthyroid patients followed for at least 6 months. Height, weight, clinical features, biochemistry and management were recorded at each clinic visit. Documented weight gain was 5.42 +/- 0.46 kg (mean +/- SE) and increase in BMI was 8.49 +/- 0.71%, over a mean 24.2 +/- 1.6 months. Pre-existing obesity, Graves' disease causing hyperthyroidism, weight loss before presentation and length of follow-up each independently predicted weight gain. Patients treated with thionamides or radioiodine gained a similar amount of weight (thionamides, n = 87, 5.16 +/- 0.63 kg vs. radioiodine, n = 62, 4.75 +/- 0.57 kg, P = 0.645), but patients who underwent thyroidectomy (n = 13) gained more weight (10.27 +/- 2.56 kg vs. others, P = 0.007). Development of hypothyroidism (even transiently) was associated with weight gain (never hypothyroid, n = 102, 4.57 +/- 0.52 kg, transiently hypothyroid, n = 29, 5.37 +/- 0.85 kg, on T4, n = 31, 8.06 +/- 1.42 kg, P = 0.014). This difference remained after correcting for length of follow-up. In the whole cohort, weight increased by 3.95 +/- 0.40 kg at 1 year (n = 144) to 9.91 +/- 1.62 kg after 4 years (n = 27) (P = 0.008), representing a mean weight gain of 3.66 +/- 0.44 kg/year. We have demonstrated marked weight gain after treatment of hyperthyroidism. Pre-existing obesity, a diagnosis of Graves' disease and prior weight loss independently predicted weight gain and weight continued to rise with time. Patients who became hypothyroid, despite T4 replacement, gained most weight.

  2. Fuel cells are gaining ground. Fuel cells as a key technology: future potential, state of the art, economic aspects, practical reports. Proceedings. Brennstoffzellen auf dem Vormarsch. Die Brennstoffzelle als Schluesseltechnologie. Zukunftspotentiale, Stand der Technik, Wirtschaftlichkeit und Praxisberichte. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    1999-01-01

    This conference report comprises 16 papers on fuel cells. Subjects: Funds for fuel cell technology provided by the 4. programme for energy research and energy technologies; Funds provided by the European Commission for demonstration projects; Fuel cells: Stationary applications in power supply; Liberalisation of the energy markets - effects on fuel cell development; Fuel cell technology from a utility's point of view; PEMFC membrane fuel cells; PFC in domestic energy supply; Applications of PEMFC in stationary power generation; Development of a fuel cell drive; Comparative evaluations of passenger car drives with fuel cells and internal combustion engines; Economic aspects of PAFC fuel cells; Development of the carbonate fuel cell (MCFC); Demonstration plant at Santa Clara (MCFC); Development, demonstration and application of oxide ceramics fuel cells SOFC, Experience with SOFC. Four contributions are available as separate records in this database.

  3. Large intracranial vessel occlusion arising after radiotherapy for craniopharingioma. A case report and review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Noguchi, Osamu; Iwasa, Satoshi; Kohno, Norio; Nozaki, Miwako (Kiryu Kohsei General Hospital, Gunma (Japan))

    1994-10-01

    We report a patient who developed occlusion of the intracranial major arteries induced by radiation therapy for craniopharyngioma. The patient, a 9-year-old boy, presented with deterioration of vision, nausea and vomiting. He underwent a right ventriculo-peritoneal shunt operation, and the tumor was partially removed. Postoperatively, he received focal radiation therapy with total of 60 Gy. Preoperative cerebral angiography, cerebral vessels had no sigh of occlusive lesion or stenosis. One year after irradiation, he started to have repeated cerebral ischemic attacks. But no regrowth of the tumor was detected on CT scans. Two years and 8 months after irradiation, he suddenly had right hemiparesis. Cerebral angiography revealed severe stenosis of the right anterior cerebral artery (precommunicating segment), middle cerebral artery (horizontal portion) and terminal portion of the right carotid artery. Left carotid angiography showed complete occlusion of the terminal portion of the internal carotid artery and collateral vessels from the middle meningeal artery to the middle cerebral artery through the shunt burr hole. He has been treated conservatively and is doing well except for slight right hemiparesis. Our experience shows that the risk of occlusive cerebrovasculopathy after radiation therapy should be taken into account, especially in children. (author).

  4. Final Technical Report for Quantum Embedding for Correlated Electronic Structure in Large Systems and the Condensed Phase

    Energy Technology Data Exchange (ETDEWEB)

    Chan, Garnet Kin-Lic [Princeton Univ., NJ (United States)

    2017-04-30

    This is the final technical report. We briefly describe some selected results below. Developments in density matrix embedding. DMET is a quantum embedding theory that we introduced at the beginning of the last funding period, around 2012-2013. Since the first DMET papers, which demonstrated proof-of- principle calculations on the Hubbard model and hydrogen rings, we have carried out a number of different developments, including: Extending the DMET technology to compute broken symmetry phases, including magnetic phases and super- conductivity (Pub. 13); Calibrating the accuracy of DMET and its cluster size convergence against other methods, and formulation of a dynamical cluster analog (Pubs. 4, 10) (see Fig. 1); Implementing DMET for ab-initio molecular calculations, and exploring different self-consistency criteria (Pubs. 9, 14); Using embedding to defi ne quantum classical interfaces Pub. 2; Formulating DMET for spectral functions (Pub. 7) (see Fig. 1); Extending DMET to coupled fermion-boson problems (Pub. 12). Together with these embedding developments, we have also implemented a wide variety of impurity solvers within our DMET framework, including DMRG (Pub. 3), AFQMC (Pub. 10), and coupled cluster theory (CC) (Pub. 9).

  5. Brief report: large individual variation in outcomes of autistic children receiving low-intensity behavioral interventions in community settings.

    Science.gov (United States)

    Kamio, Yoko; Haraguchi, Hideyuki; Miyake, Atsuko; Hiraiwa, Mikio

    2015-01-01

    Despite widespread awareness of the necessity of early intervention for children with autism spectrum disorders (ASDs), evidence is still limited, in part, due to the complex nature of ASDs. This exploratory study aimed to examine the change across time in young children with autism and their mothers, who received less intensive early interventions with and without applied behavior analysis (ABA) methods in community settings in Japan. Eighteen children with autism (mean age: 45.7 months; range: 28-64 months) received ABA-based treatment (a median of 3.5 hours per week; an interquartile range of 2-5.6 hours per week) and/or eclectic treatment-as-usual (TAU) (a median of 3.1 hours per week; an interquartile range of 2-5.6 hours per week). Children's outcomes were the severity of autistic symptoms, cognitive functioning, internalizing and externalizing behavior after 6 months (a median of 192 days; an interquartile range of 178-206 days). In addition, maternal parenting stress at 6-month follow-up, and maternal depression at 1.5-year follow-up (a median of 512 days; an interquartile range of 358-545 days) were also examined. Large individual variations were observed for a broad range of children's and mothers' outcomes. Neither ABA nor TAU hours per week were significantly associated with an improvement in core autistic symptoms. A significant improvement was observed only for internalizing problems, irrespective of the type, intensity or monthly cost of treatment received. Higher ABA cost per month (a median of 1,188 USD; an interquartile range of 538-1,888 USD) was associated with less improvement in language-social DQ (a median of 9; an interquartile range of -6.75-23.75). To determine an optimal program for each child with ASD in areas with poor ASD resources, further controlled studies are needed that assess a broad range of predictive and outcome variables focusing on both individual characteristics and treatment components.

  6. High gain multigap avalanche detectors for Cerenkov ring imaging

    Energy Technology Data Exchange (ETDEWEB)

    Gilmore, R.S.; Lavender, W.M.; Leith, D.W.G.S.; Williams, S.H.

    1980-10-01

    We report on a continuing study of multigap parallel plate avalanche chambers, primarily as photoelectron detectors for use with Cerenkov ring imaging counters. By suitable control of the fields in successive gaps and by introducing screens to reduce photon feedback to the cathode the gain many be increased considerably. We have obtained gains in excess of 6 x 10/sup 7/ for photoelectrons with a good pulse height spectrum and expect to increase this further. We discuss the use of resistive anodes to give avalanche positions in two dimensions by charge division.

  7. Sudden losses and sudden gains during a DBT-PTSD treatment for posttraumatic stress disorder following childhood sexual abuse

    Directory of Open Access Journals (Sweden)

    Antje Krüger

    2014-09-01

    Full Text Available Background: Exposure-based treatment approaches are first-line interventions for patients suffering from posttraumatic stress disorder (PTSD. However, the dissemination of exposure-based treatments for PTSD is challenging, as a large proportion of clinicians report being concerned about symptoms worsening as a result of this type of intervention and are therefore reluctant to offer it to patients with PTSD. However, there is only little empirical evidence to date on the pattern of symptom worsening during exposure-based treatment for PTSD. Objective: The goal of the present study was to explore the frequency of sudden losses and sudden gains in the course of an exposure-based treatment programme for female patients suffering from PTSD related to childhood sexual abuse who also show severe comorbidity. In addition, the relationship between sudden changes and treatment outcome was examined. Methods: Female participants (N=74 were randomised to either a 12-week residential DBT-PTSD programme or a treatment-as-usual wait list. The pattern of symptom change was assessed via weekly assessments using the Posttraumatic Diagnostic Scale (PDS. Sudden changes were computed as suggested by the literature on sudden gains. Results: During treatment, only one participant (3% experienced a sudden loss, whereas 25% of participants experienced sudden gains. In the waiting condition, 8% of the participants experienced sudden losses and 5% experienced sudden gains during the same time period. No symptom worsening was observed in response to exposure sessions. However, sudden gains occurred during exposure and non-exposure treatment weeks. Patients with sudden gains showed better treatment outcome in the post-treatment and follow-up assessments. Conclusions: Exposure-based treatment did not lead to PTSD symptom worsening in the study sample. Results show that sudden gains occur frequently during PTSD treatment and have a prognostic value for treatment outcome.

  8. Examination of Routine Use of Prenatal Weight Gain Charts as a Communication Tool for Providers.

    Science.gov (United States)

    Aguilera, Marijo; Sidebottom, Abbey C; McCool, Brigitte R

    2017-10-01

    Objectives In 2009 the IOM revised prenatal weight gain guidelines. The primary purpose of this pilot study was to assess if provider education and use of prenatal weight gain charts to track weight gain and counsel patients was associated with better patient and provider knowledge and communication about the guidelines. Methods A prospective non-randomized study conducted in four OB practices (two control, two intervention). Data sources included provider surveys (n = 16 intervention, 21 control), patient surveys (n = 332), and medical records. Intervention clinics received provider education on the IOM guidelines and used patient education materials and prenatal weight gain charts to track weight gain and as a counseling tool. Comparison clinics received no education and did not use the charts or patient education information. Results More patients at intervention clinics (92.3%) reported that a provider gave them advice about weight gain, compared to patients from comparison clinics (66.4%) (p gain (83.1 vs. 64.3%, p = 0.007). Intervention clinic patients were more likely to have knowledge of the guidelines indicated by 72.3% reporting a target weight gain amount within the guidelines versus 50.4% of comparison patients (p gain charts resulted in higher patient reported communication about weight gain from their provider, higher patient satisfaction with those discussions, and better knowledge of the appropriate target weight gain goals.

  9. Maximum gain of Yagi-Uda arrays

    DEFF Research Database (Denmark)

    Bojsen, J.H.; Schjær-Jacobsen, Hans; Nilsson, E.

    1971-01-01

    Numerical optimisation techniques have been used to find the maximum gain of some specific parasitic arrays. The gain of an array of infinitely thin, equispaced dipoles loaded with arbitrary reactances has been optimised. The results show that standard travelling-wave design methods are not optimum....... Yagi–Uda arrays with equal and unequal spacing have also been optimised with experimental verification....

  10. Gain Shift Corrections at Chi-Nu

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Tristan Brooks [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. of Massachusetts, Lowell, MA (United States). Dept. of Physics and Applied Physics; Devlin, Matthew James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-30

    Ambient conditions have the potential to cause changes in liquid scintillator detector gain that vary with time and temperature. These gain shifts can lead to poor resolution in both energy as well as pulse shape discrimination. In order to correct for these shifts in the Chi-Nu high energy array, a laser system has been developed for calibration of the pulse height signals.

  11. Nonunity gain minimal-disturbance measurement

    DEFF Research Database (Denmark)

    Sabuncu, Metin; Mišta, L.; Fiurášek, J.

    2007-01-01

    We propose and experimentally demonstrate an optimal nonunity gain Gaussian scheme for partial measurement of an unknown coherent state that causes minimal disturbance of the state. The information gain and the state disturbance are quantified by the noise added to the measurement outcomes...

  12. Efficiency gains, bounds, and risk in finance

    NARCIS (Netherlands)

    Sarisoy, Cisil

    2015-01-01

    This thesis consists of three chapters. The first chapter analyzes efficiency gains in the estimation of expected returns based on asset pricing models and examines the economic implications of such gains in portfolio allocation exercises. The second chapter provides nonparametric efficiency bounds

  13. Evaluating realized genetic gains from tree improvement.

    Science.gov (United States)

    J.B. St. Clair

    1993-01-01

    Tree improvement has become an essential part of the management of forest lands for wood production, and predicting yields and realized gains from forests planted with genetically-improved trees will become increasingly important. This paper discusses concepts of tree improvement and genetic gain important to growth and yield modeling, and reviews previous studies of...

  14. An efficient fast response and high-gain solar-blind flexible ultraviolet photodetector employing hybrid geometry

    Science.gov (United States)

    Hussain, Amreen A.; Pal, Arup R.; Patil, Dinkar S.

    2014-05-01

    We report high performance flexible hybrid ultraviolet photodetector with solar-blind sensitivity using nanocomposite film of plasma polymerized aniline-titanium dioxide. A facile solvent-free plasma technique is used to synthesize superior quality hybrid material with high yield. The hybrid photodetector exhibited high photoconductive gain of the order of ˜105 and fast speed with response and recovery time of 22.87 ms and 34.23 ms. This is an excellent result towards getting a balance in the response speed and photoconductive gain trade-off of the photodetectors reported so far. In addition, the device has the advantages of enhanced photosensitivity ((Ilight - Idark)/Idark) of the order of ˜102 and high responsivity of ˜104 AW-1. All the merits substantiates that, to prepare hybrid material, plasma based method holds potential to be an easy way for realizing large scale nanostructured photodetectors for practical applications.

  15. Medical Gains of Chondroitin Sulfate Upon Fucosylation.

    Science.gov (United States)

    Pomin, Vitor H

    2015-01-01

    Chondroitin sulfate (CS) is a glycosaminoglycan (GAG) composed of alternating N-acetyl galactosamine and glucuronic acid units within disaccharide building blocks. CS is a key functional component in proteoglycans of cartilaginous tissues. Owing to its numerous biological roles, CS is widely explored in the pharmaceutical market as nutraceutical ingredient commonly utilized against arthritis, osteoarthrosis, and sometimes osteoporosis. Tissues like shark cartilage and bovine trachea are common sources of CS. Nonetheless, a new CS type has been introduced and investigated in the last few decades in what regards its medical potentials. It is named fucosylated chondroitin sulfate (FucCS). This less common CS type is isolated exclusively from the body wall of sea cucumbers. The presence of fucosyl branching units in the holothurian FucCS gives to this unique GAG, therapeutic properties in various pathophysiological systems which are inexistent in the common CS explored in the market. Examples of these systems are coagulation, thrombosis, hemodialysis, atherosclerosis, cellular growth, angiogenesis, fibrosis, tumor growth, inflammation, viral and protozoan infections, hyperglycemia, diabetes-related pathological events and tissue damage. This report aims at describing the medical benefits gained upon fucosylation of CS. Clinical prospects of these medical benefits are also discussed herein.

  16. The Association of Antidepressant Medication and Body Weight Gain.

    Directory of Open Access Journals (Sweden)

    Sara Ranjbar

    2013-04-01

    Full Text Available Objective: To review the literature and discover which antidepressants are responsible for weight gain and then to discuss the areas with lack of adequate knowledge. Method: An electronic search was conducted through Medline, Pubmed, Cochrane library, and ScienceDirect. Forty nine empirical researches were identified and reviewed. Results: Amitriptyline, clomipramine, and mirtazapine have been associated with more weight gain induction in clinical studies, but not in animal-based studies. All TCAs have been reported to cause weight gain except protriptyline. MAOIs have been associated with weight gain. In SSRI group, citalopram and ecitalopram induce weight, yet mixed results exist for paroxetine and fluoxetine. Researches unanimously reported weight loss effect for bupropion. Some studies suggest contributing factors in the relationship of antidepressants with body weight changes including age, gender, base-line weights and treatment duration. Various results of different treatment durations have been reported in some cases but there are not continuous time-dependent studies for the influences of antidepressants on body weight changes. Conclusion: More studies are required to discover underlying mechanisms and the time-dependent effects of antidepressants on body weight changes.

  17. Gain control mechanisms in spinal motoneurons

    Directory of Open Access Journals (Sweden)

    Michael David Johnson

    2014-07-01

    Full Text Available Motoneurons provide the only conduit for motor commands to reach muscles. For many years, motoneurons were in fact considered to be little more than passive wires. Systematic studies in the past 25 years however have clearly demonstrated that the intrinsic electrical properties of motoneurons are under strong neuromodulatory control via multiple sources. The discovery of potent neuromodulation from the brainstem and its ability to change the gain of motoneurons shows that the passive view of the motor output stage is no longer tenable. A mechanism for gain control at the motor output stage makes good functional sense considering our capability of generating an enormous range of forces, from very delicate (e.g. putting in a contact lens to highly forceful (emergency reactions. Just as sensory systems need gain control to deal with a wide dynamic range of inputs, so to might motor output need gain control to deal with the wide dynamic range of the normal movement repertoire. Two problems emerge from the potential use of the brainstem monoaminergic projection to motoneurons for gain control. First, the projection is highly diffuse anatomically, so that independent control of the gains of different motor pools is not feasible. In fact, the system is so diffuse that gain for all the motor pools in a limb likely increases in concert. Second, if there is a system that increases gain, probably a system to reduce gain is also needed. In this review, we summarize recent studies that show local inhibitory circuits within the spinal cord, especially reciprocal and recurrent inhibition, have the potential to solve both of these problems as well as constitute another source of gain modulation.

  18. Measurements and modeling of gain coefficients for neodymium laser glasses

    International Nuclear Information System (INIS)

    Linford, G.J.; Saroyan, R.A.; Trenholme, J.B.; Weber, M.J.

    1979-01-01

    Small-signal gain coefficients are reported for neodymium in silicate, phosphate, fluorophosphate, and fluoroberyllate laser glasses. Measurements were made in a disk amplifier under identical conditions. Using spectroscopic data as the input, amplifier gain is calculated as a fucntion of flashlamp energy, pumping pulse duration, disk thickness, and Nd-doping. The agreement between predicted and measured gains is generally with ;plus or minus;10 percent, consistent with experimental uncertainties in the model and the parameters used. The operating conditions which optimize amplifier performance and efficiency for a given laser glass may be found using spectroscopic data alone. This process can be extended to derive the most cost-effective staging of amplifier chains for fusion lasers. A discussion of the model and examples of calculations are presented

  19. Weight Gain and Hair Loss during Anti-TNF Therapy

    Directory of Open Access Journals (Sweden)

    Abdo Lutf

    2012-01-01

    Full Text Available Objectives. To investigate the incidence of weight gain and hair loss as adverse effects of anti-TNF therapy in rheumatic diseases. Methods. Patients using anti-TNF therapy, who are followed in rheumatology clinic, were interviewed using a questionnaire to investigate the side effects of anti-TNF therapy. Patients who complained of hair loss and weight gain were asked additional questions concerning the relationship of these adverse effects to anti-TNF use, whether therapy was stopped because of these adverse effects and if the adverse effects reversed after stopping therapy. The files were reviewed to follow the weight change before, during, and after discontinuation of anti-TNF. Results. One hundred fifty consecutive patients (82 RA, 34 ankylosing spondylitis, 32 psoriatic arthritis, and 4 for other indications were interviewed .Weight gain was observed in 20 patients (13.3% with average gain of 5.5 Kg. Anti-TNF was stopped in five patients because of this adverse effect. Hair loss during anti-TNf therapy was reported in five females (3.3% and anti-TNF therapy was stopped in all of them. Conclusion. Weight gain and hair loss appear to be associated with anti-TNF therapy and may be one reason for discontinuing the therapy.

  20. Dye gain gold NW array of surface plasmon polariton waveguide

    Directory of Open Access Journals (Sweden)

    Jun Zhu

    Full Text Available Plasmon lasers can support ultrasmall mode confinement and ultrafast dynamics with device feature sizes below the diffraction limit. At present in the single visible light frequency, the optical gain method of constraint SPP on metal nanowires structure reported less. We design the gold nanowire array structure, consisting of PMMA and R6G dye molecules as gain, by 488 nm pump in the middle of the nanowires position for wide range of light, use symmetry broken overcome that momentum does not match the photonic and SPP energy conversion. Theoretical analysis shows that dyes provide coherent optical feedback, resulting in nanowires face will observe laser properties of surface plasmons. Feature analysis: the incident light and pump joint strength is greater than the sum of strength which is the incident light, pump respectively. Under the effect of dye molecules gain effective, length of SPP transmission can increase 1 µm. The results achieved in a single optical frequency of stimulated radiation, application of dye optical gain can achieve continuous gain effect. This is for the future development of plasma amplifier and the wavelength laser. Keywords: SPP, Stimulated radiation, Gold nanowires array, Dye molecules

  1. CD7 Positive Diffuse Large B-Cell Lymphoma Arising in a Background of Follicular Lymphoma: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Elham Vali Betts

    2016-01-01

    Full Text Available Diffuse large B-cell lymphoma (DLBCL is a neoplasm of large B-lymphocytes with a diffuse growth pattern. The neoplastic cells express B-cell markers such as CD20 and PAX-5 and there may be coexpression of BCL-2, BCL-6, CD10, and MUM-1. With the exception of CD5, other T-cell markers are not commonly expressed in this neoplasm. Here, we describe the first reported case of a DLBCL with abnormal expression CD7 arising in a background of follicular lymphoma in an 81-year-old male who presented with a nontender left axillary mass. Additionally, no other T-cell antigens were expressed in this B-cell lymphoma. Expression of CD7 in DLBCL is exceptionally rare and its prognostic significance is unknown. Here, we describe this rare case with review of literature of known DLBCLs with expression of T-cell antigens.

  2. The Role of Morphology and Electronic Chain Aggregation on the Optical Gain Properties of Semiconducting Conjugated Polymers

    Science.gov (United States)

    Lampert, Zachary Evan

    thresholds and large net gains are highly desirable. In this thesis, we also discuss novel routes we developed for enhancement of ASE performance in MEH-PPV thin film planar waveguides. The first technique relied on improving the distribution of the TE0 guided mode in the CP gain layer through optimization of waveguide architecture. This was achieved by fabricating symmetric heterostructure waveguides formed from a core layer of MEH-PPV sandwiched between an SiO2 buffer and index matched poly(methyl methacrylate) (PMMA) cover layer. Relative to asymmetric waveguides of Si(100)/SiO2/MEH-PPV/Air, symmetric waveguides exhibited increased optical confinement and reduced propagation loss enabling lower ASE threshold (40%) and higher net gain (50%). Independent of device architecture and degree of aggregation in the films, we discovered that optical gain is also highly dependent on the excitation conditions, specifically the temporal width of the pump laser pulses. A 400% increase in net gain was achieved under transient (25 picosecond pulses), compared to quasi-steady state (8 nanosecond pulses), excitation conditions. This large difference is attributed to low pumping efficiency and increased non-radiative recombination under ns pumping, which reduces the emission cross-section resulting in a net decrease in gain. The gain values we achieved in the ps regime are to the best of our knowledge the largest gain values reported to date for thin conjugated polymer films measured using the variable stripe length (VSL) technique. Films pumped in the transient regime also required 30 times less pump energy density to reach threshold in comparison with films pumped in the quasi-steady state regime, although the excited state densities were essentially the same. These results demonstrate that the pumping efficiency, and hence generation rate of excited states in a gain medium, can be dramatically increased by using pump laser pulses that are shorter than the exciton luminescence lifetime

  3. Design issues for a laboratory high gain fusion facility

    International Nuclear Information System (INIS)

    Hogan, W.J.

    1987-01-01

    In an inertial fusion laboratory high gain facility, experiments will be carried out with up to 1000 MJ of thermonuclear yield. The experiment area of such a facility will include many systems and structures that will have to operate successfully in the difficult environment created by the sudden large energy release. This paper estimates many of the nuclear effects that will occur, discusses the implied design issues and suggests possible solutions so that a useful experimental facility can be built. 4 figs

  4. Optimal weight gain in triplet pregnancies.

    Science.gov (United States)

    Johnston, Robert C; Erfani, Hadi; Shamshirsaz, Amir A; Spiel, Melissa; Ravangard, Sam F; Shaman, Majid; Allaf, M Baraa; Shamshirsaz, Alireza A; Haeri, Sina

    2017-08-01

    To identify appropriate weight gain in triplet gestations, which may aid in reducing the risk of perinatal morbidity within this high-risk cohort. This retrospective cohort study evaluated all non-anomalous triplet pregnancies between 23 and 40 weeks' gestation resulting in live births at five tertiary-care medical centers between 1991 and 2011. Subjects were divided by pre-pregnancy BMI into underweight, normal-weight, overweight, and obese groups, and then stratified by low (gain (≥1.5 lbs/week). Primary outcomes included spontaneous preterm birth and preeclampsia. We included 116 mothers and 348 corresponding neonates for final analysis. The incidence of preeclampsia and preterm delivery less than 32 weeks' gestation was 37% and 41%, respectively. The incidence of preeclampsia increased with weight gain per week, but was not statistically different from subjects who gained less weight. We found no statistical correlation between weight gain per week and preterm delivery. We found no association between preeclampsia or preterm delivery and increasing weight gain in triplet pregnancies. The association with increased risk for preeclampsia was predominantly due to BMI effect. Based on the current study, recommendations for optimal weight gain in mothers with triplet gestations could not be defined.

  5. Controlling gain one photon at a time

    Science.gov (United States)

    Schwartz, Gregory W; Rieke, Fred

    2013-01-01

    Adaptation is a salient property of sensory processing. All adaptational or gain control mechanisms face the challenge of obtaining a reliable estimate of the property of the input to be adapted to and obtaining this estimate sufficiently rapidly to be useful. Here, we explore how the primate retina balances the need to change gain rapidly and reliably when photons arrive rarely at individual rod photoreceptors. We find that the weakest backgrounds that decrease the gain of the retinal output signals are similar to those that increase human behavioral threshold, and identify a novel site of gain control in the retinal circuitry. Thus, surprisingly, the gain of retinal signals begins to decrease essentially as soon as background lights are detectable; under these conditions, gain control does not rely on a highly averaged estimate of the photon count, but instead signals from individual photon absorptions trigger changes in gain. DOI: http://dx.doi.org/10.7554/eLife.00467.001 PMID:23682314

  6. Intrinsic gain modulation and adaptive neural coding.

    Directory of Open Access Journals (Sweden)

    Sungho Hong

    2008-07-01

    Full Text Available In many cases, the computation of a neural system can be reduced to a receptive field, or a set of linear filters, and a thresholding function, or gain curve, which determines the firing probability; this is known as a linear/nonlinear model. In some forms of sensory adaptation, these linear filters and gain curve adjust very rapidly to changes in the variance of a randomly varying driving input. An apparently similar but previously unrelated issue is the observation of gain control by background noise in cortical neurons: the slope of the firing rate versus current (f-I curve changes with the variance of background random input. Here, we show a direct correspondence between these two observations by relating variance-dependent changes in the gain of f-I curves to characteristics of the changing empirical linear/nonlinear model obtained by sampling. In the case that the underlying system is fixed, we derive relationships relating the change of the gain with respect to both mean and variance with the receptive fields derived from reverse correlation on a white noise stimulus. Using two conductance-based model neurons that display distinct gain modulation properties through a simple change in parameters, we show that coding properties of both these models quantitatively satisfy the predicted relationships. Our results describe how both variance-dependent gain modulation and adaptive neural computation result from intrinsic nonlinearity.

  7. Improving Genetic Gain with Genomic Selection in Autotetraploid Potato

    Directory of Open Access Journals (Sweden)

    Anthony T. Slater

    2016-11-01

    Full Text Available Potato ( L. breeders consider a large number of traits during cultivar development and progress in conventional breeding can be slow. There is accumulating evidence that some of these traits, such as yield, are affected by a large number of genes with small individual effects. Recently, significant efforts have been applied to the development of genomic resources to improve potato breeding, culminating in a draft genome sequence and the identification of a large number of single nucleotide polymorphisms (SNPs. The availability of these genome-wide SNPs is a prerequisite for implementing genomic selection for improvement of polygenic traits such as yield. In this review, we investigate opportunities for the application of genomic selection to potato, including novel breeding program designs. We have considered a number of factors that will influence this process, including the autotetraploid and heterozygous genetic nature of potato, the rate of decay of linkage disequilibrium, the number of required markers, the design of a reference population, and trait heritability. Based on estimates of the effective population size derived from a potato breeding program, we have calculated the expected accuracy of genomic selection for four key traits of varying heritability and propose that it will be reasonably accurate. We compared the expected genetic gain from genomic selection with the expected gain from phenotypic and pedigree selection, and found that genetic gain can be substantially improved by using genomic selection.

  8. Tumor-mimicking large vegetation attached to the tricuspid valve without predisposing factors: A case report on CT and echocardiographic findings

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Jung Min; Choe, Yeon Hyeon; Hwang, Hye Won; Kim, Jung Sun; Kim, Wook Sung; Peck, Kyong Ran; Park, Sung Ji [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2015-10-15

    We report the CT and echocardiographic findings of a tumor-mimicking large vegetation attached to the tricuspid valve (TV) of a 45-year-old man without predisposing factors. Echocardiography revealed a mobile homogeneous echogenic mass attached to the TV. Cardiac CT showed a 4.5 × 2.3 cm irregular low-density mass with scant enhancement in the right ventricle. Based on clinical findings of fever, positive blood culture results for Streptococcus viridans, and pathologic confirmation of the lesion, a diagnosis of infective endocarditis and vegetation was made.

  9. Tumor-mimicking large vegetation attached to the tricuspid valve without predisposing factors: A case report on CT and echocardiographic findings

    International Nuclear Information System (INIS)

    Bae, Jung Min; Choe, Yeon Hyeon; Hwang, Hye Won; Kim, Jung Sun; Kim, Wook Sung; Peck, Kyong Ran; Park, Sung Ji

    2015-01-01

    We report the CT and echocardiographic findings of a tumor-mimicking large vegetation attached to the tricuspid valve (TV) of a 45-year-old man without predisposing factors. Echocardiography revealed a mobile homogeneous echogenic mass attached to the TV. Cardiac CT showed a 4.5 × 2.3 cm irregular low-density mass with scant enhancement in the right ventricle. Based on clinical findings of fever, positive blood culture results for Streptococcus viridans, and pathologic confirmation of the lesion, a diagnosis of infective endocarditis and vegetation was made

  10. Coexistence of chronic myeloid leukemia and diffuse large B-cell lymphoma with antecedent chronic lymphocytic leukemia: a case report and review of the literature.

    Science.gov (United States)

    Abuelgasim, Khadega A; Rehan, Hinna; Alsubaie, Maha; Al Atwi, Nasser; Al Balwi, Mohammed; Alshieban, Saeed; Almughairi, Areej

    2018-03-11

    Chronic lymphocytic leukemia and chronic myeloid leukemia are the most common types of adult leukemia. However, it is rare for the same patient to suffer from both. Richter's transformation to diffuse large B-cell lymphoma is frequently observed in chronic lymphocytic leukemia. Purine analog therapy and the presence of trisomy 12, and CCND1 gene rearrangement have been linked to increased risk of Richter's transformation. The coexistence of chronic myeloid leukemia and diffuse large B-cell lymphoma in the same patient is extremely rare, with only nine reported cases. Here, we describe the first reported case of concurrent chronic myeloid leukemia and diffuse large B-cell lymphoma in a background of chronic lymphocytic leukemia. A 60-year-old Saudi man known to have diabetes, hypertension, and chronic active hepatitis B was diagnosed as having Rai stage II chronic lymphocytic leukemia, with trisomy 12 and rearrangement of the CCND1 gene in December 2012. He required no therapy until January 2016 when he developed significant anemia, thrombocytopenia, and constitutional symptoms. He received six cycles of fludarabine, cyclophosphamide, and rituximab, after which he achieved complete remission. One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly. Fluorescence in situ hybridization from bone marrow aspirate was positive for translocation (9;22) and reverse transcription polymerase chain reaction detected BCR-ABL fusion gene consistent with chronic myeloid leukemia. He had no morphologic or immunophenotypic evidence of chronic lymphocytic leukemia at the time. Imatinib, a first-line tyrosine kinase inhibitor, was started. Eight months later, a screening imaging revealed new liver lesions, which were confirmed to be diffuse large B-cell lymphoma. In chronic lymphocytic leukemia, progressive leukocytosis and splenomegaly caused by emerging chronic myeloid leukemia can be easily overlooked. It is unlikely that chronic myeloid

  11. Point Information Gain and Multidimensional Data Analysis

    Directory of Open Access Journals (Sweden)

    Renata Rychtáriková

    2016-10-01

    Full Text Available We generalize the point information gain (PIG and derived quantities, i.e., point information gain entropy (PIE and point information gain entropy density (PIED, for the case of the Rényi entropy and simulate the behavior of PIG for typical distributions. We also use these methods for the analysis of multidimensional datasets. We demonstrate the main properties of PIE/PIED spectra for the real data with the examples of several images and discuss further possible utilizations in other fields of data processing.

  12. TCAD simulation of Low Gain Avalanche Detectors

    Science.gov (United States)

    Dalal, Ranjeet; Jain, Geetika; Bhardwaj, Ashutosh; Ranjan, Kirti

    2016-11-01

    In the present work, detailed simulation using Technology Computer Aided Design (TCAD) tool, Silvaco for non-irradiated and irradiated LGAD (Low Gain Avalanche Detector) devices has been carried out. The effects of different design parameters and proton irradiation on LGAD operation are discussed in detail. An already published effective two trap bulk damage model is used to simulate the radiation damage without implementing any acceptor removal term. The TCAD simulation for irradiated LGAD devices produce decreasing gain with increasing fluence, similar to the measurement results. The space charge density and electric field distribution are used to illustrate the possible reasons for the degradation of gain of the irradiated LGAD devices.

  13. TCAD simulation of Low Gain Avalanche Detectors

    Energy Technology Data Exchange (ETDEWEB)

    Dalal, Ranjeet; Jain, Geetika; Bhardwaj, Ashutosh, E-mail: ashutosh.bhardwaj@cern.ch; Ranjan, Kirti

    2016-11-11

    In the present work, detailed simulation using Technology Computer Aided Design (TCAD) tool, Silvaco for non-irradiated and irradiated LGAD (Low Gain Avalanche Detector) devices has been carried out. The effects of different design parameters and proton irradiation on LGAD operation are discussed in detail. An already published effective two trap bulk damage model is used to simulate the radiation damage without implementing any acceptor removal term. The TCAD simulation for irradiated LGAD devices produce decreasing gain with increasing fluence, similar to the measurement results. The space charge density and electric field distribution are used to illustrate the possible reasons for the degradation of gain of the irradiated LGAD devices.

  14. TCAD simulation of Low Gain Avalanche Detectors

    International Nuclear Information System (INIS)

    Dalal, Ranjeet; Jain, Geetika; Bhardwaj, Ashutosh; Ranjan, Kirti

    2016-01-01

    In the present work, detailed simulation using Technology Computer Aided Design (TCAD) tool, Silvaco for non-irradiated and irradiated LGAD (Low Gain Avalanche Detector) devices has been carried out. The effects of different design parameters and proton irradiation on LGAD operation are discussed in detail. An already published effective two trap bulk damage model is used to simulate the radiation damage without implementing any acceptor removal term. The TCAD simulation for irradiated LGAD devices produce decreasing gain with increasing fluence, similar to the measurement results. The space charge density and electric field distribution are used to illustrate the possible reasons for the degradation of gain of the irradiated LGAD devices.

  15. Postoperative weight gain after standard Whipple's procedure versus pylorus-preserving pancreatoduodenectomy: the influence of tumour status

    NARCIS (Netherlands)

    van Berge Henegouwen, M. I.; Moojen, T. M.; van Gulik, T. M.; Rauws, E. A.; Obertop, H.; Gouma, D. J.

    1998-01-01

    BACKGROUND: Recent reports suggest a better postoperative weight gain after pylorus-preserving pancreatoduodenectomy (PPPD) compared with standard pancreatoduodenectomy (PD). Factors that could also influence postoperative weight gain, such as tumour-positive resection margins and tumour recurrence,

  16. Gains in Life Expectancy Associated with Higher Education in Men.

    Science.gov (United States)

    Bijwaard, Govert E; van Poppel, Frans; Ekamper, Peter; Lumey, L H

    2015-01-01

    Many studies show large differences in life expectancy across the range of education, intelligence, and socio-economic status. As educational attainment, intelligence, and socio-economic status are highly interrelated, appropriate methods are required to disentangle their separate effects. The aim of this paper is to present a novel method to estimate gains in life expectancy specifically associated with increased education. Our analysis is based on a structural model in which education level, IQ at age 18 and mortality all depend on (latent) intelligence. The model allows for (selective) educational choices based on observed factors and on an unobserved factor capturing intelligence. Our estimates are based on information from health examinations of military conscripts born in 1944-1947 in The Netherlands and their vital status through age 66 (n = 39,798). Our empirical results show that men with higher education have lower mortality. Using structural models to account for education choice, the estimated gain in life expectancy for men moving up one educational level ranges from 0.3 to 2 years. The estimated gain in months alive over the observational period ranges from -1.2 to 5.7 months. The selection effect is positive and amounts to a gain of one to two months. Decomposition of the selection effect shows that the gain from selection on (latent) intelligence is larger than the gain from selection on observed factors and amounts to 1.0 to 1.7 additional months alive. Our findings confirm the strong selection into education based on socio-economic status and intelligence. They also show significant higher life expectancy among individuals with higher education after the selectivity of education choice has been taken into account. Based on these estimates, it is plausible therefore that increases in education could lead to increases in life expectancy.

  17. The Impact of Kangaroo Care on Premature Infant Weight Gain.

    Science.gov (United States)

    Evereklian, Melvina; Posmontier, Bobbie

    Preterm births occur among 11.4% of all live infant births. Without steady weight gain, premature infants may experience lengthy hospitalizations, neurodevelopmental deficits and hospital readmissions, which can increase the financial burden on the health care system and their families. The total U.S. health-related costs linked to preterm infant deliveries are estimated at $4.33 billion. Kangaroo care is a feasible practice that can improve preterm infant weight gain. However, this intervention is utilized less often throughout the U.S. due to numerous barriers including a lack of consistent protocols, inadequate knowledge, and decreased level of confidence in demonstrating the proper kangarooing technique. An integrative review was conducted to evaluate the impact of kangaroo care on premature infant weight gain in order to educate nurses about its efficacy among preterm infants. A literature search was conducted using CINAHL, PubMed, Cochrane Reviews, ClinicalKey and Google Scholar. Large volume searches were restricted using appropriate filters and limiters. Most of the evaluated studies determined that weight gain was greater among the kangarooing premature infants. Kangaroo care is a low-tech low-cost modality that can facilitate improved preterm infant weight gain even in low-resource settings. Despite its current efficacy, kangaroo care is not widely utilized due to several barriers including an absence of standardized protocols and a lack of knowledge about its benefits. Kangaroo care can become a widespread formalized practice after nurses and parents learn about the technique and its numerous benefits for premature infants, including its association with improved weight gain. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Active rc filter permits easy trade-off of amplifier gain and sensitivity to gain

    Science.gov (United States)

    Kerwin, W. J.; Shaffer, C. V.

    1968-01-01

    Passive RC network was designed with zeros of transmission in the right half of the complex frequency plane in the feedback loop of a simple negative-gain amplifier. The proper positioning provides any desired trade-off between amplifier gain and sensitivity to amplifier gain.

  19. MOS current gain cells with electronically variable gain and constant bandwidth

    NARCIS (Netherlands)

    Klumperink, Eric A.M.; Seevinck, Evert

    1989-01-01

    Two MOS current gain cells are proposed that provide linear amplification of currents supplied by several linear MOS V-I converters. The gain is electronically variable by a voltage or a current and can be made insensitive to temperature and IC processing. The gain cells have a constant

  20. Detective quantum efficiency gains compared with speed gains for hypersensitized astronomical plates

    International Nuclear Information System (INIS)

    Kaye, A.L.

    1977-01-01

    It is reasonable to assume that gains in detective quantum efficiency (DQE) are far better criteria for assessing the performance of hypersensitizing techniques than gains in speed. It is shown here that gains in speed can be misleading, for some methods of hypersensitization give plates of increased speed but reduced detective quantum efficiency. (author)

  1. Flexible CIGS solar cells on large area polymer foils with in-line deposition methods and application of alternative back contacts - Final report

    Energy Technology Data Exchange (ETDEWEB)

    Tiwari, A. N.

    2009-08-15

    This illustrated report for the Swiss Federal Office of Energy (SFOE) summarises the work performed within this project and also reports on synergies with other projects that helped to make a significant contribution to the development of CIGS thin film solar cells on flexible substrates such as polymer foils. The project's aims were to learn more about up-scaling issues and to demonstrate the abilities required for the processing of layers on large area polyimide foils for flexible CIGS solar cells. Custom-built evaporators that were designed and constructed in-house are described. A CIGS system for in-line deposition was also modified for roll-to-roll deposition and alternative electrical back contacts to conventional ones were evaluated on flexible polyimide foils. The objectives of the project and the results obtained are looked at and commented on in detail.

  2. Analysis of the Economic Impact of Large-Scale Deployment of Biomass Resources for Energy and Materials in the Netherlands. Macro-economics biobased synthesis report

    International Nuclear Information System (INIS)

    Hoefnagels, R.; Dornburg, V.; Faaij, A.; Banse, M.

    2009-03-01

    The Bio-based Raw Materials Platform (PGG), part of the Energy Transition in The Netherlands, commissioned the Agricultural Economics Research Institute (LEI) and the Copernicus Institute of Utrecht University to conduct research on the macro-economic impact of large scale deployment of biomass for energy and materials in the Netherlands. Two model approaches were applied based on a consistent set of scenario assumptions: a bottom-up study including technoeconomic projections of fossil and bio-based conversion technologies and a topdown study including macro-economic modelling of (global) trade of biomass and fossil resources. The results of the top-down and bottom-up modelling work are reported separately. The results of the synthesis of the modelling work are presented in this report

  3. Diffuse large B cell lymphoma of thyroid as a masquerader of anaplastic carcinoma of thyroid, diagnosed by FNA: a case report

    Directory of Open Access Journals (Sweden)

    Dehghani Mehdi

    2006-01-01

    Full Text Available Abstract Background Both thyroid lymphoma and anaplastic carcinoma of thyroid present with rapidly growing mass in eldery patients. Anaplastic carcinoma has high mortality rate and combination of surgery, radiation therapy and multidrug chemotherapy are the best chance for cure. Prognosis of thyroid lymphoma is excellent and chemotherapy for widespred lymphoms and radiotherapy with or without adjuvant chemotherapy for tumors localized to the gland, are the treatment of choice. Case report This article reports a 70 year old man presenting with diffuse neck swelling and hoarseness of few weeks duration. Fine needle aspiration was done and reported as anaplastic carcinoma of thyroid which thyroidectomy was planned. The slides were sent for second opinion. After review, with initial diagnosis of anaplastic carcinoma versus lymphoma, immunocytochemical study was performed. Smears were positive for B cell markers and negative for cytokeratin, so with the impression of diffuse large B cell lymphoma, the patient received two courses of chemotherapy by which the tumor disappeared during two weaks. Conclusion Despite previous reports, stating easy diagnosis of high-grade thyroid lymphoma on the grounds of cytomorphological features we like to emphasize, overlapping cytologic features of the curable high grade thyroid lymphoma form noncurable anaplastic thyroid carcinoma and usefulness of immunocytochemistry to differentiate these two disease.

  4. Optical properties of nanowire metamaterials with gain

    DEFF Research Database (Denmark)

    Isidio de Lima, Joaquim Junior; Adam, Jost; Rego, Davi

    2016-01-01

    The transmittance, reflectance and absorption of a nanowire metamaterial with optical gain are numerically simulated and investigated. It is assumed that the metamaterial is represented by aligned silver nanowires embedded into a semiconductor matrix, made of either silicon or gallium phosphide....... The gain in the matrix is modeled by adding a negative imaginary part to the dielectric function of the semiconductor. It is found that the optical coefficients of the metamaterial depend on the gain magnitude in a non-trivial way: they can both increase and decrease with gain depending on the lattice...... constant of the metamaterial. This peculiar behavior is explained by the field redistribution between the lossy metal nanowires and the amplifying matrix material. These findings are significant for a proper design of nanowire metamaterials with low optical losses for diverse applications....

  5. Active Microwave Metamaterials Incorporating Ideal Gain Devices

    Directory of Open Access Journals (Sweden)

    Hao Xin

    2010-12-01

    Full Text Available Incorporation of active devices/media such as transistors for microwave and gain media for optics may be very attractive for enabling desired low loss and broadband metamaterials. Such metamaterials can even have gain which may very well lead to new and exciting physical phenomena. We investigate microwave composite right/left-handed transmission lines (CRLH-TL incorporating ideal gain devices such as constant negative resistance. With realistic lumped element values, we have shown that the negative phase constant of this kind of transmission lines is maintained (i.e., left-handedness kept while gain can be obtained (negative attenuation constant of transmission line simultaneously. Possible implementation and challenging issues of the proposed active CRLH-TL are also discussed.

  6. Transient optical gain in germanium quantum wells

    Energy Technology Data Exchange (ETDEWEB)

    Chatterjee, Sangam; Lange, Christoph; Koester, Niko S.; Schaefer, Martin; Kira, Mackillo; Koch, Stephan W. [Faculty of Physics and Materials Sciences Center, Philipps-Universitaet Marburg (Germany); Chrastina, Daniel; Isella, Giovanni; Kaenel, Hans von [CNISM, Como (Italy); L-NESS, Dipartimento di Fisica del Politecnico di Milano, Como (Italy); Sigg, Hans [Laboratory for Micro and Nanotecnology, Paul Scherrer Institut, Villigen PSI (Switzerland)

    2010-07-01

    One of today's most-sought goals in semiconductor technology is the monolithic integration of microelectronics and photonics on Si. Optical gain is, in general, not expected for Si and Ge or its alloys due to the indirect nature of the band gap in this material system. Here, we show that Ge/SiGe QWs show transient optical gain and may thus be used as an optically-pumped amplifier at room temperature. Further, the nonequilibrium effects which govern the relaxation dynamics of the optically injected carrier distributions in this material were observed and analyzed using a microscopic many-body theory. Strong non-equilibrium gain was obtained on a sub-100 fs time scale. Long-lived gain arising from {gamma}-point transitions is overcompensated by a process bearing the character of free carrier absorption.

  7. Genetic Variation in the Leptin Receptor Gene, Leptin, and Weight Gain in Young Dutch Adults

    NARCIS (Netherlands)

    Rossum, van C.T.M.; Hoebee, B.; Baak, van M.A.; Mars, M.; Saris, W.H.M.; Seidell, J.C.

    2003-01-01

    Objective: To investigate the association between leptin levels, polymorphisms in the leptin receptor (LEPR) gene, and weight gain. Research Methods and Procedures: From two large prospective cohorts in The Netherlands (n = 17, 500), we compared the baseline leptin of 259 subjects who had gained an

  8. Genetic factors as predictors of weight gain in young adult Dutch men and women

    NARCIS (Netherlands)

    Rossum, van C.T.M.; Hoebee, B.; Seidell, J.C.; Bouchard, C.; Baak, van M.A.; Groot, de C.P.G.M.; Chagnon, M.; Graaf, de C.; Saris, W.H.M.

    2002-01-01

    OBJECTIVE: To investigate the association between DNA polymorphisms in several candidate genes for obesity and weight gain. Polymorphisms in these genes may contribute to weight gain through effects on energy intake, energy expenditure or adipogenesis. DESIGN AND METHODS: From two large cohorts in

  9. Analysis and Evaluation of Performance Gains and Tradeoffs for Massive MIMO Systems

    Directory of Open Access Journals (Sweden)

    Saba Qasim Jabbar

    2016-09-01

    Full Text Available Massive MIMO technique offers significant performance gains for the future of wireless communications via improving the spectral efficiency, energy efficiency and the channel quality with simple linear processing such as maximum-ratio transmission (MRT or zero-forcing (ZF by providing each user a large degree of freedom. In this paper, the system performance gains are studied in a multi-cell downlink massive MIMO system under the main considerations such as perfect channel estimation, imperfect channel estimation and the effect of interference among cells due to pilot sequences contamination. Then, mathematical expressions are derived for these gains i.e., spatial multiplexing gain, array gain and spatial diversity gain. After that, essential tradeoffs among these gains are considered under the effect of non-orthogonal interference, these tradeoffs are: spatial diversity gain vs. spatial multiplexing gain and array gain vs. spatial multiplexing gain. Simulation results show that the unbounded number of base station antennas boosts the array gain through concentrating the energy to spatial directions where users are sited, hence diminishing loss in array gain due to pilot contamination. The simulation results reveal also that massive MIMO strengthens the spatial multiplexing gain through increasing the number of served users via the same system resources in spite the effect of inter-cell interference. Finally, the spatial diversity gain is measured in term of outage probability and the simulation results show that raising the number of antennas will improve the outage probability. Meanwhile increasing the number of served users will lead to degrade the outage probability per user due to non-orthogonal interference from other cells.

  10. Renyi information gain on quantum key

    International Nuclear Information System (INIS)

    Brandt, Howard E

    2007-01-01

    The concept of maximum Renyi information gain from quantum key is important in eavesdropping and security analyses of quantum key distribution. It is particularly useful in the design optimization of eavesdropping probes. The present work reviews the quantitative measure of Renyi information gain, its optimization, and application to the design of eavesdropping probes in which single-photon probe states become optimally entangled with the signal states on their way between the legitimate transmitter and receiver

  11. Enhanced Gain in Photonic Crystal Amplifiers

    DEFF Research Database (Denmark)

    Ek, Sara; Semenova, Elizaveta; Hansen, Per Lunnemann

    2012-01-01

    We experimentally demonstrate enhanced gain in the slow-light regime of quantum well photonic crystal amplifiers. A strong gain enhancement is observed with the increase of the group refractive index, due to light slow-down. The slow light enhancement is shown in a amplified spontaneous emission....... These results are promising for short and efficient semiconductor optical amplifiers. This effect will also benefit other devices, such as mode locked lasers....

  12. Identification of a novel large intragenic deletion in a family with Fanconi anemia: first molecular report from India and review of literature.

    Science.gov (United States)

    Shukla, Pallavi; Rao, Anita; Ghosh, Kanjaksha; Vundinti, Babu Rao

    2013-04-15

    We report here an Indian case with Fanconi anemia (FA) presented with fever, pallor, short stature, hyperpigmentation and upper limb anomaly. Chromosome breakage analysis together with FANCD2 Western blot monoubiquitination assay confirmed the diagnosis as FA. Multiplex ligation-dependent probe amplification (MLPA) revealed a novel homozygous large intragenic deletion (exons 8-27 del) in the FANCA gene in the proband. His sib and parents were also analyzed and found to be heterozygous for the same mutation. We also reviewed the literature of FANCA large intragenic deletions found in FA patients from different countries and the mechanism involved in the formation of these deletions. To the best of our knowledge, this is the first molecular report from India on FA. The finding expands the mutation spectrum of the FANCA gene. Identification of the mutation confirms the diagnosis of FA at DNA level and helps in providing proper genetic counseling to the family. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. Enucleation of a large true cyst in the head of pancreas instead of Whipple procedure in an 8-year old boy: a case report

    Directory of Open Access Journals (Sweden)

    Ostadian N

    2011-02-01

    Full Text Available "nBackground: Simple cysts of pancreas are smaller than complex ones and are more likely to be located at the distal tail of the pancreas. Simple cysts are often asymptomatic and can be managed conservatively by observation. There seems to be few clinical trials to suggest the best treatments method for large symptomatic cysts of pancreas located at the head of the organ."n "nCase presentation: In this report, we describe an eight-year old boy with a large symptomatic true cyst at the head of the pancreas who was successfully treated by enucleation of the cyst, instead of the Whipple's procedure, without any ensuing complications."n "nConclusion: Regarding the rarity of simple cysts in the pancreas, lack of studies to compare different surgical procedures and suggest the best methods to treat them and the considerable morbidity and even mortality of major surgeries (e.g Whipple's procedure enucleation of these cysts seem to be appropriate for treating them with no early or late complications. More studies are needed to warrant the results of this report.

  14. Cone Beam Computed Tomography Evaluation of the Diagnosis, Treatment Planning, and Long-Term Followup of Large Periapical Lesions Treated by Endodontic Surgery: Two Case Reports

    Directory of Open Access Journals (Sweden)

    Vijay Shekhar

    2013-01-01

    Full Text Available The aim of this case report is to present two cases where cone beam computed tomography (CBCT was used for the diagnosis, treatment planning, and followup of large periapical lesions in relation to maxillary anterior teeth treated by endodontic surgery. Periapical disease may be detected sooner using CBCT, and their true size, extent, nature, and position can be assessed. It allows clinician to select the most relevant views of the area of interest resulting in improved detection of periapical lesions. CBCT scan may provide a better, more accurate, and faster method to differentially diagnose a solid (granuloma from a fluid-filled lesion or cavity (cyst. In the present case report, endodontic treatment was performed for both the cases followed by endodontic surgery. Biopsy was done to establish the confirmatory histopathological diagnosis of the periapical lesions. Long-term assessment of the periapical healing following surgery was done in all the three dimensions using CBCT and was found to be more accurate than IOPA radiography. It was concluded that CBCT was a useful modality in making the diagnosis and treatment plan and assessing the outcome of endodontic surgery for large periapical lesions.

  15. Cone Beam Computed Tomography Evaluation of the Diagnosis, Treatment Planning, and Long-Term Followup of Large Periapical Lesions Treated by Endodontic Surgery: Two Case Reports

    Science.gov (United States)

    Shekhar, Vijay; Shashikala, K.

    2013-01-01

    The aim of this case report is to present two cases where cone beam computed tomography (CBCT) was used for the diagnosis, treatment planning, and followup of large periapical lesions in relation to maxillary anterior teeth treated by endodontic surgery. Periapical disease may be detected sooner using CBCT, and their true size, extent, nature, and position can be assessed. It allows clinician to select the most relevant views of the area of interest resulting in improved detection of periapical lesions. CBCT scan may provide a better, more accurate, and faster method to differentially diagnose a solid (granuloma) from a fluid-filled lesion or cavity (cyst). In the present case report, endodontic treatment was performed for both the cases followed by endodontic surgery. Biopsy was done to establish the confirmatory histopathological diagnosis of the periapical lesions. Long-term assessment of the periapical healing following surgery was done in all the three dimensions using CBCT and was found to be more accurate than IOPA radiography. It was concluded that CBCT was a useful modality in making the diagnosis and treatment plan and assessing the outcome of endodontic surgery for large periapical lesions. PMID:23762646

  16. Gingival Anaplastic Large-Cell Lymphoma Mimicking Hyperplastic Benignancy as the First Clinical Manifestation of AIDS: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Rafaela Elvira Rozza-de-Menezes

    2013-01-01

    Full Text Available This paper presents an unusual case of gingival ALCL, which mimicked a benign hyperplastic lesion that occurred in a 57-year-old white man representing the first clinical manifestation of acquired immunodeficiency syndrome (AIDS. The patient was referred to the Dental Clinic of PUCPR complaining of a lobulated nodule on the gingiva of his upper central incisors. The presence of advanced chronic periodontitis and dental plaque raised suspicion for a benignancy. An excisional biopsy was performed, and large pleomorphic cells with an abundant cytoplasm, sometimes containing prominent nucleoli and “Hallmark” cells, were observed through hematoxylin and eosin staining. The tumor cells showed strong CD30 expression, EMA, Ki-67, and LCA, and negative stain for p80NPM/ALK, CKAE1/AE3, CD20, CD3, CD56, and CD15. The final diagnosis was ALCL (ALK-negative. Further laboratory tests revealed positivity for human immunodeficiency virus (HIV. The patient was submitted to chemotherapy, but four months after diagnosis, the patient died due to pneumonia and respiratory failure. Oral anaplastic large-cell lymphoma (ALCL is a rare disorder. Only 5 cases involving the gingiva have been reported, and to our knowledge, this is the first case reported of the ALCL, which mimicked a hyperplastic benignancy as the first clinical manifestation of AIDS.

  17. Central gain control in tinnitus and hyperacusis

    Directory of Open Access Journals (Sweden)

    Benjamin D Auerbach

    2014-10-01

    Full Text Available Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural activity transmitted from the cochlea to the central auditory system. Despite a reduced cochlear output, neural activity from more central auditory structures is paradoxically enhanced at suprathreshold intensities. This compensatory increase in the central auditory activity in response to the loss of sensory input is referred to as central gain enhancement. Enhanced central gain is hypothesized to be a potential mechanism that gives rise to hyperacusis and tinnitus, two debilitating auditory perceptual disorders that afflict millions of individuals. This review will examine the evidence for gain enhancement in the central auditory system in response to cochlear damage. Further, it will address the potential cellular and molecular mechanisms underlying this enhancement and discuss the contribution of central gain enhancement to tinnitus and hyperacusis. Current evidence suggests that multiple mechanisms with distinct temporal and spectral profiles are likely to contribute to central gain enhancement. Dissecting the contributions of these different mechanisms at different levels of the central auditory system is essential for elucidating the role of central gain enhancement in tinnitus and hyperacusis and, most importantly, the development of novel treatments for these disorders.

  18. Central Gain Control in Tinnitus and Hyperacusis

    Science.gov (United States)

    Auerbach, Benjamin D.; Rodrigues, Paulo V.; Salvi, Richard J.

    2014-01-01

    Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural activity transmitted from the cochlea to the central auditory system. Despite a reduced cochlear output, neural activity from more central auditory structures is paradoxically enhanced at suprathreshold intensities. This compensatory increase in the central auditory activity in response to the loss of sensory input is referred to as central gain enhancement. Enhanced central gain is hypothesized to be a potential mechanism that gives rise to hyperacusis and tinnitus, two debilitating auditory perceptual disorders that afflict millions of individuals. This review will examine the evidence for gain enhancement in the central auditory system in response to cochlear damage. Further, it will address the potential cellular and molecular mechanisms underlying this enhancement and discuss the contribution of central gain enhancement to tinnitus and hyperacusis. Current evidence suggests that multiple mechanisms with distinct temporal and spectral profiles are likely to contribute to central gain enhancement. Dissecting the contributions of these different mechanisms at different levels of the central auditory system is essential for elucidating the role of central gain enhancement in tinnitus and hyperacusis and, most importantly, the development of novel treatments for these disorders. PMID:25386157

  19. The Role of Large-Format Histopathology in Assessing Subgross Morphological Prognostic Parameters: A Single Institution Report of 1000 Consecutive Breast Cancer Cases

    Directory of Open Access Journals (Sweden)

    Tibor Tot

    2012-01-01

    Full Text Available Breast cancer subgross morphological parameters (disease extent, lesion distribution, and tumor size provide significant prognostic information and guide therapeutic decisions. Modern multimodality radiological imaging can determine these parameters with increasing accuracy in most patients. Large-format histopathology preserves the spatial relationship of the tumor components and their relationship to the resection margins and has clear advantages over traditional routine pathology techniques. We report a series of 1000 consecutive breast cancer cases worked up with large-format histology with detailed radiological-pathological correlation. We confirmed that breast carcinomas often exhibit complex subgross morphology in both early and advanced stages. Half of the cases were extensive tumors and occupied a tissue space ≥40 mm in its largest dimension. Because both in situ and invasive tumor components may exhibit unifocal, multifocal, and diffuse lesion distribution, 17 different breast cancer growth patterns can be observed. Combining in situ and invasive tumor components, most cases fall into three aggregate growth patterns: unifocal (36%, multifocal (35%, and diffuse (28%. Large-format histology categories of tumor size and disease extent were concordant with radiological measurements in approximately 80% of the cases. Noncalcified, low-grade in situ foci, and invasive tumor foci <5 mm were the most frequent causes of discrepant findings.

  20. Treatment of giant and large fusiform middle cerebral artery aneurysms with excision and interposition radial artery graft in a 4-year-old child: case report.

    Science.gov (United States)

    Mrak, Goran; Paladino, Josip; Stambolija, Vasilije; Nemir, Jakob; Sekhar, Laligam N

    2014-03-01

    We report an unusual case of complex giant and large fusiform aneurysms not amenable for clipping or coiling in a 4-year-old child managed with aneurysm resection and radial artery interposition graft. A 4-year-old child presented with repeated severe headache and vomiting. Computed tomography, magnetic resonance imaging, and magnetic resonance angiography and digital subtraction angiography showed a giant fusiform aneurysm on the right middle cerebral artery (MCA). Because of the complex shape, endovascular treatment or clip reconstruction was not possible, and a bypass procedure was planned. Right frontotemporal craniotomy and orbitotomy was performed. Two aneurysms involving the M1 segment of the MCA were found in line, 1 giant, and the other large in size. The aneurysms were resected and treated with short radial artery interposition graft, which was narrower than the proximal or distal MCA. The child recovered normally, and the bypass was patent after 1 year. Large fusiform MCA aneurysms may be difficult to treat, but there are treatment options that include a bypass procedure. Resection and short interposition radial artery graft is an excellent but rare treatment option in a very young child. This was a very successful treatment in this child.

  1. Enhancing optical gains in Si nanocrystals via hydrogenation and cerium ion doping

    International Nuclear Information System (INIS)

    Wang, Dong-Chen; Li, Yan-Li; Song, Sheng-Chi; Guo, Wen-Ping; Lu, Ming; Chen, Jia-Rong

    2014-01-01

    We report optical gain enhancements in Si nanocrystals (Si-NCs) via hydrogenation and Ce 3+ ion doping. Variable stripe length technique was used to obtain gains. At 0.3 W/cm 2 pumping power density of pulsed laser, net gains were observed together with gain enhancements after hydrogenation and/or Ce 3+ ion doping; gains after loss corrections were between 89.52 and 341.95 cm −1 ; and the photoluminescence (PL) lifetime was found to decrease with the increasing gain enhancement. At 0.04 W/cm 2 power density, however, no net gain was found and the PL lifetime increased with the increasing PL enhancement. The results were discussed according to stimulated and spontaneous excitation and de-excitation mechanisms of Si-NCs.

  2. You Spin my Head Right Round: Threshold of Limited Immersion for Rotation Gains in Redirected Walking.

    Science.gov (United States)

    Schmitz, Patric; Hildebrandt, Julian; Valdez, Andre Calero; Kobbelt, Leif; Ziefle, Martina

    2018-04-01

    In virtual environments, the space that can be explored by real walking is limited by the size of the tracked area. To enable unimpeded walking through large virtual spaces in small real-world surroundings, redirection techniques are used. These unnoticeably manipulate the user's virtual walking trajectory. It is important to know how strongly such techniques can be applied without the user noticing the manipulation-or getting cybersick. Previously, this was estimated by measuring a detection threshold (DT) in highly-controlled psychophysical studies, which experimentally isolate the effect but do not aim for perceived immersion in the context of VR applications. While these studies suggest that only relatively low degrees of manipulation are tolerable, we claim that, besides establishing detection thresholds, it is important to know when the user's immersion breaks. We hypothesize that the degree of unnoticed manipulation is significantly different from the detection threshold when the user is immersed in a task. We conducted three studies: a) to devise an experimental paradigm to measure the threshold of limited immersion (TLI), b) to measure the TLI for slowly decreasing and increasing rotation gains, and c) to establish a baseline of cybersickness for our experimental setup. For rotation gains greater than 1.0, we found that immersion breaks quite late after the gain is detectable. However, for gains lesser than 1.0, some users reported a break of immersion even before established detection thresholds were reached. Apparently, the developed metric measures an additional quality of user experience. This article contributes to the development of effective spatial compression methods by utilizing the break of immersion as a benchmark for redirection techniques.

  3. Identification of the first large deletion in the CLDN16 gene in a patient with FHHNC and late-onset of chronic kidney disease: case report.

    Science.gov (United States)

    Yamaguti, Paulo Marcio; dos Santos, Pollyanna Almeida Costa; Leal, Bruno Sakamoto; Santana, Viviane Brandão Bandeira de Mello; Mazzeu, Juliana Forte; Acevedo, Ana Carolina; Neves, Francisco de Assis Rocha

    2015-07-02

    Familial hypomagnesemia with hypercalciuria and nephrocalcinosis is a rare autosomal recessive renal disease characterized by tubular disorders at the thick ascending limb of Henle's loop. It is caused by mutations in the tight junction structural proteins claudin-16 or claudin-19, which are encoded by the CLDN16 and CLDN19 genes, respectively. Patients exhibit excessive wasting of calcium and magnesium, nephrocalcinosis, chronic kidney disease, and early progression to end-stage renal failure during infancy. We here report the phenotype and molecular analysis of a female Brazilian patient with a novel large homozygous deletion in the CLDN16 gene. The proband, born from consanguineous parents, presented the first symptoms at age 20. Clinical examination revealed hypocalcemia, hypomagnesemia, nephrocalcinosis, mild myopia, high serum levels of uric acid and intact parathyroid hormone, and moderate chronic kidney disease (stage 3). She and her mother were subjected to CLDN16 and CLDN19 mutational analysis. In addition, the multiplex ligation-dependent probe amplification method was used to confirm a CLDN16 multi-exon deletion. Direct sequencing revealed a normal CLDN19 sequence and suggested a large deletion in the CLDN16 gene. Multiplex ligation-dependent probe amplification showed a homozygous CLDN16 multi-exon deletion (E2_E5del). The patient initiated conventional treatment for familial hypomagnesemia with hypercalciuria and nephrocalcinosis and progressed to end-stage kidney disease after five years. This study provides the first report of a large homozygous deletion in the CLDN16 gene causing familial hypomagnesemia with hypercalciuria and nephrocalcinosis with late onset of the first symptoms. This description expands the phenotypic and genotypic characterization of the disease. The late-onset chronic kidney disease in the presence of a homozygous deletion in the CLDN16 gene reinforces the great variability of genotype-phenotype manifestation in patients with

  4. Gaining Momentum, Losing Ground. Tapping America's Potential, Progress Report 2008

    Science.gov (United States)

    Tapping America's Potential, 2008

    2008-01-01

    In July 2005, 15 of America's most prominent business organizations joined together to express their deep concern about the ability of the United States to sustain its scientific and technological leadership in a world where newly energized foreign competitors are investing in the capacity for innovation--the key driver of productivity and…

  5. Department's Negotiated Rulemaking Process for Gainful Employment. Final Audit Report.

    Science.gov (United States)

    US Department of Education, 2012

    2012-01-01

    The Department of Education (Department) is required to use negotiated rulemaking to develop proposed regulations for programs authorized under Title IV of the Higher Education Act of 1965, as amended (HEA). Under negotiated rulemaking, the Department works to develop the proposed regulations in collaboration with representatives of the parties…

  6. The effect of the Thanksgiving Holiday on weight gain

    Directory of Open Access Journals (Sweden)

    Dinger Mary K

    2006-11-01

    Full Text Available Abstract Background More people than ever are considered obese and the resulting health problems are evident. These facts highlight the need for identification of critical time periods for weight gain. Therefore the purpose was to assess potential changes that occur in body weight during the Thanksgiving holiday break in college students. Methods 94 college students (23.0 ± 4.6 yrs, 72.1 ± 14.0 kg, 172.6 ± 9.3 cm, 24.0 ± 3.9 kg/m2 reported to the human body composition laboratory at the University of Oklahoma following a 6-hour fast with testing occurring prior to, and immediately following the Thanksgiving holiday break (13 ± 3 days. Body weight (BW was assessed using a balance beam scale while participants were dressed in minimal clothing. Paired t-tests were used to assess changes in BW pre and post Thanksgiving holiday with additional analysis by gender, body mass index (BMI, and class standing (i.e. undergraduate vs. graduate. Results Overall, a significant (P P P 2 group compared to a non significant 0.2 kg gain in the normal group (2. Conclusion These data indicate that participants in our study gained a significant amount of BW (0.5 kg during the Thanksgiving holiday. While an increase in BW of half a kilogram may not be cause for alarm, the increase could have potential long-term health consequences if participants retained this weight gain throughout the college year. Additionally, because the overweight/obese participants gained the greatest amount of BW, this group may be at increased risk for weight gain and further obesity development during the holiday season.

  7. Emotional eating as a mediator between depression and weight gain.

    Science.gov (United States)

    van Strien, Tatjana; Konttinen, Hanna; Homberg, Judith R; Engels, Rutger C M E; Winkens, Laura H H

    2016-05-01

    Depression is often associated with weight gain but underlying mechanisms are unclear. This study assessed whether three psychological eating styles (emotional eating, external eating and restrained eating) act as mediators between depression and weight gain. We used structural equation modelling to test the hypothesized mediation models in a sample of 298 fathers and 294 mothers by assessing self-reported eating styles (Dutch Eating Behavior Questionnaire), depressive feelings (Depressive Mood List) and body mass index (BMI) at baseline and BMI after five years. In the model with emotional eating we also assessed the moderation effect of 5-HTTLPR genotype in a sub-sample of 520 Caucasians. All analyses were performed separately for the two sexes. Although the overall effect of depression on weight gain was statistically non-significant in both sexes, there was a causal chain between depression, emotional eating and weight gain in the mothers. Depressive symptoms were related to higher emotional eating and emotional eating predicted greater increases in BMI independently of depression. Moreover, the indirect effect (via emotional eating) of depression on BMI change was significant (Beta = 0.18, P = 0.026). This mediation effect was found to be independent of 5-HTTLPR genotype. No such mediation effect was found for the fathers. Further, external eating and restrained eating did not act as mediators between depression and weight gain in either sex. The finding that emotional eating acted as mediator between depression and weight gain in the mothers suggests that obesity interventions should take emotional eating into account. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Summary of Pressure Gain Combustion Research at NASA

    Science.gov (United States)

    Perkins, H. Douglas; Paxson, Daniel E.

    2018-01-01

    NASA has undertaken a systematic exploration of many different facets of pressure gain combustion over the last 25 years in an effort to exploit the inherent thermodynamic advantage of pressure gain combustion over the constant pressure combustion process used in most aerospace propulsion systems. Applications as varied as small-scale UAV's, rotorcraft, subsonic transports, hypersonics and launch vehicles have been considered. In addition to studying pressure gain combustor concepts such as wave rotors, pulse detonation engines, pulsejets, and rotating detonation engines, NASA has studied inlets, nozzles, ejectors and turbines which must also process unsteady flow in an integrated propulsion system. Other design considerations such as acoustic signature, combustor material life and heat transfer that are unique to pressure gain combustors have also been addressed in NASA research projects. In addition to a wide range of experimental studies, a number of computer codes, from 0-D up through 3-D, have been developed or modified to specifically address the analysis of unsteady flow fields. Loss models have also been developed and incorporated into these codes that improve the accuracy of performance predictions and decrease computational time. These codes have been validated numerous times across a broad range of operating conditions, and it has been found that once validated for one particular pressure gain combustion configuration, these codes are readily adaptable to the others. All in all, the documentation of this work has encompassed approximately 170 NASA technical reports, conference papers and journal articles to date. These publications are very briefly summarized herein, providing a single point of reference for all of NASA's pressure gain combustion research efforts. This documentation does not include the significant contributions made by NASA research staff to the programs of other agencies, universities, industrial partners and professional society

  9. Substrate effects in high gain, low operating voltage SnSe2 photoconductor

    Science.gov (United States)

    Krishna, Murali; Kallatt, Sangeeth; Majumdar, Kausik

    2018-01-01

    High gain photoconductive devices find wide spread applications in low intensity light detection. Ultra-thin layered materials have recently drawn a lot of attention from researchers in this regard. However, in general, a large operating voltage is required to obtain large responsivity in these devices. In addition, the characteristics are often confounded by substrate induced trap effects. Here we report multi-layer SnSe2 based photoconductive devices using two different structures: (1) SiO2 substrate supported inter-digitated electrode (IDE), and (2) suspended channel. The IDE device exhibits a responsivity of ≈ {10}3 A W-1 and ≈ 8.66× {10}4 A W-1 at operating voltages of 1 mV and 100 mV, respectively—a superior low voltage performance over existing literature on planar 2D structures. However, the responsivity reduces by more than two orders of magnitude, while the transient response improves for the suspended device—providing insights into the critical role played by the channel-substrate interface in the gain mechanism. The results, on one hand, are promising for highly sensitive photoconductive applications consuming ultra-low power, and on the other hand, show a generic methodology that could be applied to other layered material based photoconductive devices as well for extracting the intrinsic behavior.

  10. Adaptive Large Neighbourhood Search

    DEFF Research Database (Denmark)

    Røpke, Stefan

    Large neighborhood search is a metaheuristic that has gained popularity in recent years. The heuristic repeatedly moves from solution to solution by first partially destroying the solution and then repairing it. The best solution observed during this search is presented as the final solution....... This tutorial introduces the large neighborhood search metaheuristic and the variant adaptive large neighborhood search that dynamically tunes parameters of the heuristic while it is running. Both heuristics belong to a broader class of heuristics that are searching a solution space using very large...... neighborhoods. The tutorial also present applications of the adaptive large neighborhood search, mostly related to vehicle routing problems for which the heuristic has been extremely successful. We discuss how the heuristic can be parallelized and thereby take advantage of modern desktop computers...

  11. Associations of neighbourhood walkability indices with weight gain.

    Science.gov (United States)

    Koohsari, Mohammad Javad; Oka, Koichiro; Shibata, Ai; Liao, Yung; Hanibuchi, Tomoya; Owen, Neville; Sugiyama, Takemi

    2018-04-03

    Inconsistent associations of neighbourhood walkability with adults' body weight have been reported. Most studies examining the relationships of walkability and adiposity are cross-sectional in design. We examined the longitudinal relationships of two walkability indices - conventional walkability and space syntax walkability, and their individual components, with weight change among adults over four years. Data were from the Physical Activity in Localities and Community study in Adelaide, Australia. In 2003-2004, 2650 adults living in 154 Census Collection Districts (CCDs) returned baseline questionnaires; in 2007-2008, the follow-up survey was completed by 1098. Participants reported their weight at baseline and at follow-up. Neighbourhood walkability indices were calculated using geographic information systems and space syntax software. Linear marginal models using generalized estimating equations with robust standard errors were fitted to examine associations of the two walkability indices and their individual components with the weight at follow-up, adjusting for baseline weight, socio-demographic variables, and spatial clustering at the level of CCD. The overall mean weight gain over four years was 1.5 kg. The two walkability indices were closely correlated (r = 0.76, p walkability indices and weight change. Among walkability components, there was a marginally significant negative association between space syntax measure of street integration and weight change: one standard deviation increment in street integration was associated with 0.31 kg less weight gain (p = 0.09). Using a prospective study design and a novel space-syntax based measure of walkability, we were not able to identify relationships between neighbourhood walkability with weight gain. This is consistent with other inconclusive findings on the built environment and obesity. Research on the built environment and adults' weight gain may need to consider not just local environments but

  12. Diffuse large B cell lymphoma of thyroid as a masquerader of anaplastic carcinoma of thyroid, diagnosed by FNA: a case report.

    Science.gov (United States)

    Daneshbod, Yahya; Omidvari, Shapour; Daneshbod, Khosrow; Negahban, Shahrzad; Dehghani, Mehdi

    2006-10-19

    Both thyroid lymphoma and anaplastic carcinoma of thyroid present with rapidly growing mass in eldery patients. Anaplastic carcinoma has high mortality rate and combination of surgery, radiation therapy and multidrug chemotherapy are the best chance for cure. Prognosis of thyroid lymphoma is excellent and chemotherapy for widespred lymphoms and radiotherapy with or without adjuvant chemotherapy for tumors localized to the gland, are the treatment of choice. This article reports a 70 year old man presenting with diffuse neck swelling and hoarseness of few weeks duration. Fine needle aspiration was done and reported as anaplastic carcinoma of thyroid which thyroidectomy was planned. The slides were sent for second opinion. After review, with initial diagnosis of anaplastic carcinoma versus lymphoma, immunocytochemical study was performed. Smears were positive for B cell markers and negative for cytokeratin, so with the impression of diffuse large B cell lymphoma, the patient received two courses of chemotherapy by which the tumor disappeared during two weaks. Despite previous reports, stating easy diagnosis of high-grade thyroid lymphoma on the grounds of cytomorphological features we like to emphasize, overlapping cytologic features of the curable high grade thyroid lymphoma form noncurable anaplastic thyroid carcinoma and usefulness of immunocytochemistry to differentiate these two disease.

  13. Optical gain and gain suppression of quantum-well lasers with valence band mixing

    International Nuclear Information System (INIS)

    Ahn, D.; Chuang, S.L.

    1990-01-01

    The effects of valence band mixing on the nonlinear gains of quantum-well lasers are studied theoretically. The authors' analysis is based on the multiband effective-mass theory and the density matrix formalism with intraband relaxation taken into account. The gain and the gain-suppression coefficient of a quantum-well laser are calculated from the complex optical susceptibility obtained by the density matrix formulation with the theoretical dipole moments obtained from the multiband effective-mass theory. The calculated gain spectrum shows that there are remarkable differences (both in peak amplitude and spectral shape) between our model with valence band mixing and the conventional parabolic band model. The shape of the gain spectrum calculated by the authors' model becomes more symmetric due to intraband relaxation together with nonparabolic energy dispersions and is closer to the experimental observations when compared with the conventional method using the parabolic band model and the multiband effective-mass calculation without intraband relaxation. Both give quite asymmetric gain spectra. Optical intensity in the GaAs active region is estimated by solving rate equations for the stationary states with nonlinear gain suppression. The authors calculate the mode gain for the resonant mode including the gain suppression, which results in spectral hole burning of the gain spectrum

  14. CONDITIONS FOR CSR MICROBUNCHING GAIN SUPPRESSION

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, Cheng Ying [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Douglas, David R. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Li, Rui [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Tennant, Christopher D. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); di Mitri, Simone [Elettra–Sincrotrone Trieste, 34149 Basovizza, Trieste, Italy

    2016-05-01

    The coherent synchrotron radiation (CSR) of a high brightness electron beam traversing a series of dipoles, such as transport arcs, may result in phase space degradation. On one hand, the CSR can perturb electron transverse motion in dispersive regions along the beamline, causing emittance growth. On the other hand, the CSR effect on the longitudinal beam dynamics could result in microbunching gain enhancement. For transport arcs, several schemes have been proposed* to suppress the CSR-induced emittance growth. Similarly, several scenarios have been introduced** to suppress CSR-induced microbunching gain, which however mostly aim for linac-based machines. In this paper we try to provide sufficient conditions for suppression of CSR-induced microbunching gain along a transport arc, analogous to*. Several example lattices are presented, with the relevant microbunching analyses carried out by our semi-analytical Vlasov solver***. The simulation results show that lattices satisfying the proposed conditions indeed have microbunching gain suppressed. We expect this analysis can shed light on lattice design approach that could suppress the CSR-induced microbunching gain.

  15. Controlling morphology and chain aggregation in semiconducting conjugated polymers: the role of solvent on optical gain in MEH-PPV.

    Science.gov (United States)

    Lampert, Zach E; Reynolds, C Lewis; Papanikolas, John M; Aboelfotoh, M Osama

    2012-10-25

    We report the results of a detailed investigation that addresses the influence of polymer morphology and chain aggregation, as controlled by the chemical nature of the solvent, on the optical gain properties of the conjugated polymer poly[2-methoxy-5-(2'-ethylhexyloxy)-p-phenylene vinylene] (MEH-PPV). Using the variable stripe length technique in the picosecond regime, we have extensively studied the optical gain performance of asymmetric planar waveguides formed with thin MEH-PPV films spin-cast from concentrated chlorobenzene (CB) and tetrahydrofuran (THF) solutions onto thermally oxidized silicon substrates. CB and THF solvents were chosen based on their known ability to promote and effectively limit aggregate formation, respectively. Very large net gain coefficients are demonstrated, reaching values of 330 and 365 cm(-1), respectively, when optically pumping the waveguides with a maximum energy density of 85 μJ/cm(2). Our results clearly demonstrate that polymer morphology, and hence, the chain conformation dependence of the degree of aggregation in the films as controlled by the solvent, has minimal impact on the net gain. Moreover, the waveguides exhibit low loss coefficients of 10-20 cm(-1) at the ASE wavelength. These results question the importance of polymer morphology and aggregate formation in polymer-based optical devices operating at high excitation densities in the stimulated emission regime as would be characteristic of lasers and optical amplifiers.

  16. The modulation of neural gain facilitates a transition between functional segregation and integration in the brain.

    Science.gov (United States)

    Shine, James M; Aburn, Matthew J; Breakspear, Michael; Poldrack, Russell A

    2018-01-29

    Cognitive function relies on a dynamic, context-sensitive balance between functional integration and segregation in the brain. Previous work has proposed that this balance is mediated by global fluctuations in neural gain by projections from ascending neuromodulatory nuclei. To test this hypothesis in silico, we studied the effects of neural gain on network dynamics in a model of large-scale neuronal dynamics. We found that increases in neural gain directed the network through an abrupt dynamical transition, leading to an integrated network topology that was maximal in frontoparietal 'rich club' regions. This gain-mediated transition was also associated with increased topological complexity, as well as increased variability in time-resolved topological structure, further highlighting the potential computational benefits of the gain-mediated network transition. These results support the hypothesis that neural gain modulation has the computational capacity to mediate the balance between integration and segregation in the brain. © 2018, Shine et al.

  17. SSI's review of the Swedish Nuclear Fuel and Waste Management Co's (SKB) report on large-scale groundwater flow modelling for eastern Smaaland in Sweden (SKB Report 06-64)

    International Nuclear Information System (INIS)

    Dverstorp, Bjorrn

    2007-09-01

    This report presents SSI's review of the Swedish Nuclear Fuel and Waste Management Co's (SKB) report (SKB Report 06-64) on large-scale groundwater flow modelling for eastern Smaaland in Sweden. SSI review is supported by two external review documents (included as appendices). SSI's review is part of a government decided consultation process on SKB's site investigations aimed at finding a suitable site for a spent nuclear fuel repository. SSI considers that SKB has presented a comprehensive study that contributes to the scientific understanding of how different factors influence the regional groundwater flow pattern. However, in SSI's opinion, SKB's evaluation of the modelling results is not complete enough to support SKB's conclusion that super regional flow conditions can be dismissed as a siting factor. SSI therefore recommends SKB to supplement their study in that respect and also to discuss the implications of identified differences in radionuclide travel times and migration distances on the overall assessment of the repository's longterm protective capability. SSI also recommends SKB to revisit some of their modelling assumptions to ensure that the model is set up in a way that does not block out large groundwater circulation cells. SSI's recommendations in this review should be regarded as guidance to SKB. SSI will make a formal assessment of how SKB has taken into account different siting factors, in connection with the review of SKB's license application to be submitted in 2009

  18. How often are patients harmed when they visit the computed tomography suite? A multi-year experience, in incident reporting, in a large academic medical center

    International Nuclear Information System (INIS)

    Mansouri, Mohammad; Aran, Shima; Shaqdan, Khalid W.; Abujudeh, Hani H.

    2016-01-01

    Our goal is to present our multi-year experience in incident reporting in CT in a large medical centre. This is an IRB-approved, HIPAA-compliant study. Informed consent was waived for this study. The electronic safety incident reporting system of our hospital was searched for the variables from April 2006 to September 2012. Incident classifications were diagnostic test orders, ID/documentation, safety/security/conduct, service coordination, surgery/procedure, line/tube, fall, medication/IV safety, employee general incident, environment/equipment, adverse drug reaction, skin/tissue and diagnosis/treatment. A total of 1918 incident reports occurred in the study period and 843,902 CT examinations were performed. The rate of safety incident was 0.22 % (1918/843,902). The highest incident rates were due to adverse drug reactions (652/843,902 = 0.077 %) followed by medication/IV safety (573/843,902 = 0.068 %) and diagnostic test orders (206/843,902 = 0.024 %). Overall 45 % of incidents (869/1918) caused no harm and did not affect the patient, 33 % (637/1918) caused no harm but affected the patient, 22 % (420/1918) caused temporary or minor harm/damage and less than 1 % (10/1918) caused permanent or major harm/damage or death. Our study shows a total safety incident report rate of 0.22 % in CT. The most common incidents are adverse drug reaction, medication/IV safety and diagnostic test orders. (orig.)

  19. Large volume liquid silicone injection in the upper thighs : a never ending story

    NARCIS (Netherlands)

    Hofer, SOP; Damen, A; Nicolai, JPA

    This report concerns a 26-year-old male-to-female transsexual who had received a large volume liquid silicone injection of unknown grade into her upper lateral thighs to gain female contour. She presented at our outpatient clinic 4 years after the silicone injection with complaints of pain and

  20. Energy Gaining Windows for Residental Buildings

    DEFF Research Database (Denmark)

    Kragh, Jesper; Laustsen, Jacob Birck; Svendsen, Svend

    2008-01-01

    window is made of fiber-reinforced plastic (plastic reinforced by fine fibers made of glass). This composite material is a weatherproof material with very low thermal conductivity and high mechanical strength. These properties make the material very suitable for frame profiles due to lower heat loss...... minus the heat loss integrated over the heating season. It is assumed that in northern cold climates all of the solar gain during the heating season can be utilized for space heating. Problems with overheating in the summer period must be solved with overhang or moveable solar shading devices. Two...... and longer durability of the window. The glazing in these fiber reinforced polyester windows is both unsealed and sealed triple glazing units. To increase the net energy gain slim frame profiles have been developed to increase the glazing area and thereby the solar gain. The challenge when developing slim...