Sample records for reported higher ars

  1. ARRA NEPA Quarterly Report- First Report: USDA ARS Report (United States)

    Council on Environmental Quality, Executive Office of the President — Reports prepared by the Departments and Agencies on status of NEPA progress for activities and projects funded under Division A of the American Recovery and...

  2. ARRA NEPA Quarterly Report- Second Report: USDA ARS Report (United States)

    Council on Environmental Quality, Executive Office of the President — Reports prepared by the Departments and Agencies on status of NEPA progress for activities and projects funded under Division A of the American Recovery and...

  3. Acoustic Resonance Spectroscopy (ARS) Munition Classification System enhancements. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Vela, O.A.; Huggard, J.C.


    Acoustic Resonance Spectroscopy (ARS) is a non-destructive evaluation technology developed at the Los Alamos National Laboratory (LANL). This technology has resulted in three generations of instrumentation, funded by the Defense Special Weapons Agency (DSWA), specifically designed for field identification of chemical weapon (CW) munitions. Each generation of ARS instrumentation was developed with a specific user in mind. The ARS1OO was built for use by the U.N. Inspection Teams going into Iraq immediately after the Persian Gulf War. The ARS200 was built for use in the US-Russia Bilateral Chemical Weapons Treaty (the primary users for this system are the US Onsite Inspection Agency (OSIA) and their Russian counterparts). The ARS300 was built with the requirements of the Organization for the Prohibition of Chemical Weapons (OPCW) in mind. Each successive system is an improved version of the previous system based on learning the weaknesses of each and, coincidentally, on the fact that more time was available to do a requirements analysis and the necessary engineering development. The ARS300 is at a level of development that warrants transferring the technology to a commercial vendor. Since LANL will supply the computer software to the selected vendor, it is possible for LANL to continue to improve the decision algorithms, add features where necessary, and adjust the user interface before the final transfer occurs. This paper describes the current system, ARS system enhancements, and software enhancements. Appendices contain the Operations Manual (software Version 3.01), and two earlier reports on enhancements.

  4. Axenfeld-Rieger syndrome (ARS): A review and case report.

    LENUS (Irish Health Repository)

    Waldron, Jennie M


    Axenfeld-Rieger syndrome (ARS) is a rare, autosomal dominant condition characterized by ocular, craniofacial, dental, and periumbilical abnormalities. Relatively little information exists on this syndrome within the dental literature despite the fact that midface hypoplasia and maxillary hypodontia are classical presenting features of this syndrome. This is a case report of a 7-year-old Caucasian female with ARS who presented with significant ocular and dental anomalies. She was also found to have osteopenia. Her dental condition is described, her immediate treatment is shown, and her long-term treatment needs are discussed.

  5. A Knock-in Reporter for a Novel AR-Targeted Therapy (United States)


    MK, Gursoy-Yuzugullu O, Xu C, Xu Y, Price BD. DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of...carrying FLuc in the AR gene locus and thereby bicistronically co-expressing the reporter gene with AR under the control of the endogenous AR promoter and...AR gene under the control of the endogenous AR promoter and enhancer. Such a knock-in reporter can faithfully reproduce chemical responses of the

  6. Higher Ambitions Summit. Rapporteur Report (United States)

    Nash, Ian


    The Sutton Trust and Pearson two-day summit on higher ambitions in apprenticeships and vocational education drew more than 120 leaders in education, training and employment, policy makers, academics, and researchers to London. Delegates heard from political leaders stressing the importance they attach to high-quality apprenticeships. Presentations…

  7. An improved ARS2-derived nuclear reporter enhances the efficiency and ease of genetic engineering in Chlamydomonas. (United States)

    Specht, Elizabeth A; Nour-Eldin, Hussam Hassan; Hoang, Kevin T D; Mayfield, Stephen P


    The model alga Chlamydomonas reinhardtii has been used to pioneer genetic engineering techniques for high-value protein and biofuel production from algae. To date, most studies of transgenic Chlamydomonas have utilized the chloroplast genome due to its ease of engineering, with a sizeable suite of reporters and well-characterized expression constructs. The advanced manipulation of algal nuclear genomes has been hampered by limited strong expression cassettes, and a lack of high-throughput reporters. We have improved upon an endogenous reporter gene - the ARS2 gene encoding an arylsulfatase enzyme - that was first cloned and characterized decades ago but has not been used extensively. The new construct, derived from ARS2 cDNA, expresses significantly higher levels of reporter protein and transforms more efficiently, allowing qualitative and quantitative screening using a rapid, inexpensive 96-well assay. The improved arylsulfatase expression cassette was used to screen a new transgene promoter from the ARG7 gene, and found that the ARG7 promoter can express the ARS2 reporter as strongly as the HSP70-RBCS2 chimeric promoter that currently ranks as the best available promoter, thus adding to the list of useful nuclear promoters. This enhanced arylsulfatase reporter construct improves the efficiency and ease of genetic engineering within the Chlamydomonas nuclear genome, with potential application to other algal strains.

  8. CALiPER Application Summary Report 17. LED AR111 and PAR36 Lamps

    Energy Technology Data Exchange (ETDEWEB)



    Report 17 analyzes the performance of a group of six LED products labeled as AR111 lamps. Results indicate that this product category lags behind other types of directional LED lamps but may perform acceptably in some applications and provide some energy savings.

  9. CALiPER Application Summary Report 17. LED AR111 and PAR36 Lamps

    Energy Technology Data Exchange (ETDEWEB)



    Report 17 analyzes the performance of a group of six LED products labeled as AR111 lamps. Results indicate that this product category lags behind other types of directional LED lamps but may perform acceptably in some applications and provide some energy savings.

  10. Conversion of K-Ar dates with modern constants : implications for recalculation of dates reported in Kawano and Ueda using constants reported by Steiger and Jager


    Iwata, Naoyoshi


    This report describes details of a procedure used to convert from K-Ar dates with old constants reported in the relevant literature to K-Ar dates with modern decay constants and the isotopic ratio of potassium reported by Steiger and Jager. Nearly 300 K-Ar dates published by Kawano and Ueda in the 1960s have been recalculated using this procedure. These data are useful for comparing dates reported by Kawano and Ueda to recently obtained K-Ar dates reported by others.

  11. The Vanishing Higher-Education Reporter (United States)

    Whitmire, Richard


    As the Internet continues to drain readers and advertising, newspapers are left with no choice but to cut back on coverage. Many papers have settled on higher education as an expendable beat. At the National Education Writers Association, which represents education reporters and editors around the country, the e-mail list for elementary- and…

  12. Development of an androgen reporter gene assay (AR-LUX) utilizing a human cell line with an endogenously regulated androgen receptor. (United States)

    Blankvoort, B M; de Groene, E M; van Meeteren-Kreikamp, A P; Witkamp, R F; Rodenburg, R J; Aarts, J M


    The aim of the work described in this report is to develop and characterize a cell-based androgen reporter assay. For this purpose, the androgen receptor (AR) expressing human breast cancer cell line T47D was stably transfected with a luciferase gene under transcriptional control of the PB-ARE-2 androgen response element. The application of this cell line in an endogenous Androgen Receptor-mediated LUciferase eXpression assay (AR-LUX) was validated. An EC50 value of 86 pM was determined for the standard androgen R1881 with a detection limit of 46 pM. Other androgens like dihydrotestosterone, 17beta-trenbolone, and bolasterone also induced luciferase expression, while anti-androgens suppressed these responses. As expected, AR-mediated responses were also elicited by high concentrations of the steroids progesterone, 17beta-estradiol, d-aldosterone, and dexamethasone, with observed EC50 values 10 to 350,000 times higher than that for R1881. A unique feature of the AR-LUX assay is that effects on modulation of active endogenous AR-levels are reliably reflected in the luciferase induction response, as exemplified by vitamin D, all-trans-retinoic acid, epigallocatechin gallate, and forskolin. This feature is especially useful when assessing complex mixtures, e.g., environmental samples or natural compound libraries. From these data it is concluded that the AR-LUX assay is a reliable in vitro test system for the detection and quantification of AR-mediated biological effects. The 96-well plate format makes the assay particularly suitable for high-throughput screening.

  13. Ars disyecta Ars disyecta

    Directory of Open Access Journals (Sweden)

    Alejandra Castillo


    Full Text Available Bajo la nominación Ars Disyecta se busca exponer el vínculo entre artes visuales, feminismo y metamorfosis. Las prácticas artísticas feministas aquí presentadas se proponen perturbar el espacio metafórico heredado de la diferencia sexual (pensemos, por ejemplo, en las palabras engendramiento, matriz, vida, compenetración o invaginamiento. En este sentido, la nominación Ars disyecta pone en escena un conjunto de prácticas e intervenciones que intentan interrumpir la matriz de la diferencia, desestabilizando lo femenino desde aquellas figuras que se resisten a la lógica de la totalidad y de un tiempo propio. Buscando seguir la huella de un arte disyecto es que interrogaré en este ensayo aquellas autorías feministas que en el arte contemporáneo trafican con las huellas del contagio, la mutación y la alteridad.This article aims to present the relation between visual arts, feminism I and metamorphosis. The feminist artistic practices portrayed in this article attempt to question categories inherited from the metaphor of sexual difference such as engendering, matrix and life. From this perspective, Ars disyecta will establish a set of artistic practices and interventions that intend to interrupt the proper idea of «feminine difference». Following this line of argument, I will discuss in this article a few contemporary feminist works of art that could be defined by words such as contagious, mutation and otherness.

  14. Catering Management in Higher Education. National Report. (United States)

    Higher Education Funding Council for England, Bristol.

    This study identified the key management issues for senior managers and heads of catering services in higher education in developing and reviewing catering services. The study was conducted with the involvement of 76 universities and colleges with evidence drawn from questionnaires covering the Excellence Model's 9 criteria, an Expert Working…

  15. AR and TD Fossil Energy Materials Program. Quarterly progress report for the period ending December 31, 1981

    Energy Technology Data Exchange (ETDEWEB)


    The ORNL Fossil Energy Materials Program Office compiles and issues this combined quarterly progress report from camera-ready copies submitted by each of the participating subcontractor organizations. This report of activities on the program is organized in accordance with a work breakdown structure defined in the AR and TD Fossil Energy Materials Program Plan for FY 1982-1986 in which projects are organized according to fossil energy technologies. This report is divided into parts and chapters with each part describing projects related to a particular fossil energy technology. Chapters within a part provide details of the various projects associated with that technology. We hope this series of AR and TD Fossil Energy Materials Program quarterly progress reports will aid in the dissemination of information developed on the program. Plans for the program will be issued annually. A draft of the program plan for FY 1982 to 1986 has been prepared and is in the review process. The implementation of these plans will be reflected by these quarterly progress reports, and this dissemination of information will bw augmented by topical or final reports as appropriate.

  16. Probing non-linearity of higher order anisotropic flow in Pb--Pb collisions arXiv

    CERN Document Server

    Zhou, You

    The second and the third order anisotropic flow, $V_{2}$ and $V_3$, are determined by the corresponding initial spatial anisotropy coefficients, $\\varepsilon_{2}$ and $\\varepsilon_{3}$, in the initial density distribution. On the contrary, the higher order anisotropic flow $V_n$ ($n > 3$), in addition to their dependence on the same order initial anisotropy coefficient $\\varepsilon_{n}$, have a significant contribution from lower order initial anisotropy coefficients, which leads to mode-coupling effects. In this contribution, we present the investigations on linear and non-linear modes in higher order anisotropic flow ($V_{4}$, $V_{5}$ and $V_{6}$) in Pb--Pb collisions at $\\sqrt{s_{\\rm NN}} =$ 2.76 TeV using the ALICE detector at the Large Hadron Collider (LHC). A significant contribution from a non-linear mode is observed. A new observable, the non-linear response coefficient, is measured as well. The comparison to theoretical calculations provides crucial information on dynamic of the created system especi...

  17. Annual Report on Higher Education in New Mexico, 1986. (United States)

    New Mexico State Commission on Postsecondary Education, Santa Fe.

    The 1986 report of the New Mexico Commission on Higher Education first outlines responsibilities of the Commission and developments concerning the Board of Educational Finance and then considers the climate for higher education reform in New Mexico, including economic changes, career changes that require retraining and skill upgrading, and…

  18. Scottish Access Students in Higher Education. Research Report Series. (United States)

    Powney, Janet; Hall, Stuart

    This document is the final report on the experiences of mature students who had entered higher education through the Scottish Wider Access Programme (SWAP), a one-year course designed to provide an alternative route into higher education for adults and which utilizes a supportive environment plus an incremental, modular approach and small-group…

  19. Report of the Select Committee on Higher Education, Texas. (United States)

    Texas Coll. and Univ. System, Austin. Coordinating Board.

    A report of a study of issues in public higher education in Texas is presented, along with recommendations of the Select Committee on Higher Education to improve access, quality, and management. Attention is directed to: institutional role and mission statements, general funding policies, research and technology funding, faculty compensation,…

  20. Statistics Report on TEQSA Registered Higher Education Providers (United States)

    Australian Government Tertiary Education Quality and Standards Agency, 2015


    This statistics report provides a comprehensive snapshot of national statistics on all parts of the sector for the year 2013, by bringing together data collected directly by TEQSA with data sourced from the main higher education statistics collections managed by the Australian Government Department of Education and Training. The report provides…

  1. Development of an androgen reporter gene assay (AR-LUX) utilizing a human cell line with an endogenously regulated androgen receptor

    NARCIS (Netherlands)

    Blankvoort, B.M.G.; Groene, E.M. de; Meeteren-Kreikamp, A.P. van; Witkamp, R.F.; Rodenburg, R.J.T.; Aarts, J.M.M.J.G.


    The aim of the work described in this report is to develop and characterize a cell-based androgen reporter assay. For this purpose, the androgen receptor (AR) expressing human breast cancer cell line T47D was stably transfected with a luciferase gene under transcriptional control of the PB-ARE-2 and

  2. Ars Electronica

    DEFF Research Database (Denmark)

    Kristensen, Thomas Bjørnsten


    Anmeldelse af Ars Electronica festivalen 3. - 8. september, 2009 i Linz, Østrig, der fejrede 30 års jubilæum under temaet "Human Nature". Festivalen fokuserer på interaktion mellem menneske, teknologi, kunst og samfund med særlig vægt på udviklingen af computeren og det digitale. Udgivelsesdato: 15.12...

  3. Ars Electronica

    DEFF Research Database (Denmark)

    Kristensen, Thomas Bjørnsten


    Anmeldelse af Ars Electronica festivalen 3. - 8. september, 2009 i Linz, Østrig, der fejrede 30 års jubilæum under temaet "Human Nature". Festivalen fokuserer på interaktion mellem menneske, teknologi, kunst og samfund med særlig vægt på udviklingen af computeren og det digitale. Udgivelsesdato: 15.12...

  4. Quality Assurance in Transnational Higher Education. ENQA Workshop Report 11 (United States)

    Bennett, Paul; Bergan, Sjur; Cassar, Daniela; Hamilton, Marlene; Soinila, Michele; Sursock, Andree; Uvalic-Trumbic, Stamenka; Williams, Peter


    The present report is the product of an ENQA (European Association for Quality Assurance in Higher Education) Bologna Seminar "Quality Assurance in Transnational Education: from words to action" hosted by the Quality Assurance Agency (QAA, UK) in London in December, 2008. The seminar discussed the current trends in Transnational…

  5. Higher Education Finance. An Annotated Bibliography, Report 96-2. (United States)

    Doyle, William

    This annotated bibliography on higher education finance lists 79 journal articles, books, conference papers, and reports originally published from 1973 through 1995 with most published in the 1990s. Citations include lengthy analytical summaries and critiques. The bibliography is presented in six sections which cover the following topics: (1)…

  6. Sustainability Reporting in Higher Education: Interconnecting the Reporting Process and Organisational Change Management for Sustainability


    Kim Ceulemans; Rodrigo Lozano; María del Mar Alonso-Almeida


    Although there has been a considerable increase in the publication of sustainability reports in the corporate world in the last decade, sustainability reporting in higher education institutions is still in its early stages. This study’s aim was to explore the relationship between sustainability reporting and organizational change management for sustainability in higher education. A survey was sent to higher education institutions worldwide that have published sustainability reports in the las...

  7. Visualizing Higher Order Finite Elements: FY05 Yearly Report.

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, David; Pebay, Philippe Pierre


    This report contains an algorithm for decomposing higher-order finite elementsinto regions appropriate for isosurfacing and proves the conditions under which thealgorithm will terminate. Finite elements are used to create piecewise polynomialapproximants to the solution of partial differential equations for which no analyticalsolution exists. These polynomials represent fields such as pressure, stress, and mo-mentim. In the past, these polynomials have been linear in each parametric coordinate.Each polynomial coefficient must be uniquely determined by a simulation, and thesecoefficients are called degrees of freedom. When there are not enough degrees of free-dom, simulations will typically fail to produce a valid approximation to the solution.Recent work has shown that increasing the number of degrees of freedom by increas-ing the order of the polynomial approximation (instead of increasing the number offinite elements, each of which has its own set of coefficients) can allow some typesof simulations to produce a valid approximation with many fewer degrees of freedomthan increasing the number of finite elements alone. However, once the simulation hasdetermined the values of all the coefficients in a higher-order approximant, tools donot exist for visual inspection of the solution.This report focuses on a technique for the visual inspection of higher-order finiteelement simulation results based on decomposing each finite element into simplicialregions where existing visualization algorithms such as isosurfacing will work. Therequirements of the isosurfacing algorithm are enumerated and related to the placeswhere the partial derivatives of the polynomial become zero. The original isosurfacingalgorithm is then applied to each of these regions in turn.3 AcknowledgementThe authors would like to thank David Day and Louis Romero for their insight into poly-nomial system solvers and the LDRD Senior Council for the opportunity to pursue thisresearch. The authors were

  8. Quantifying interference of krypton produced from neutron irradiation of inclusion-hosted and lattice-coordinated bromine with 40Ar/39Ar geochronology (United States)

    Rutte, Daniel; Becker, Tim A.; Renne, Paul R.


    Various interfering reactions producing Ar isotopes during neutron irradiation from Cl, Ar, K, and Ca have been previously detailed with the significant ones being routinely corrected for in 40Ar/39Ar geochronology. Interference of double charged 80Kr (80Kr++) with 40Ar has not yet been considered. Significant amounts of 80Kr are produced during neutron irradiation through the reaction 79Br(n,β-)80Kr. While previous workers reported a computed fission spectrum averaged cross section of ∼48 mb-compared to ∼113 mb for 39K(n,p)39Ar-we determined a ∼33-fold higher production rate of 80Kr from Br compared to 39Ar from K in the CLICIT facility of the OSU reactor. Low-K, high-Br phases, e.g., some amphiboles, and fluid or melt inclusion rich samples are prone to 80Kr++ interference biasing 40Ar/39Ar dates in the ‰ to % range. 80Kr++ resembles excess 40Ar in step-heating experiments. The interference can be corrected for by using the parallel reaction 81Br(n,β-)82Kr.

  9. FY-2016 Methyl Iodide Higher NOx Adsorption Test Report

    Energy Technology Data Exchange (ETDEWEB)

    Soelberg, Nicholas Ray [Idaho National Lab. (INL), Idaho Falls, ID (United States); Watson, Tony Leroy [Idaho National Lab. (INL), Idaho Falls, ID (United States)


    Deep-bed methyl iodide adsorption testing has continued in Fiscal Year 2016 under the Department of Energy (DOE) Fuel Cycle Technology (FCT) Program Offgas Sigma Team to further research and advance the technical maturity of solid sorbents for capturing iodine-129 in off-gas streams during used nuclear fuel reprocessing. Adsorption testing with higher levels of NO (approximately 3,300 ppm) and NO2 (up to about 10,000 ppm) indicate that high efficiency iodine capture by silver aerogel remains possible. Maximum iodine decontamination factors (DFs, or the ratio of iodine flowrate in the sorbent bed inlet gas compared to the iodine flowrate in the outlet gas) exceeded 3,000 until bed breakthrough rapidly decreased the DF levels to as low as about 2, when the adsorption capability was near depletion. After breakthrough, nearly all of the uncaptured iodine that remains in the bed outlet gas stream is no longer in the form of the original methyl iodide. The methyl iodide molecules are cleaved in the sorbent bed, even after iodine adsorption is no longer efficient, so that uncaptured iodine is in the form of iodine species soluble in caustic scrubber solutions, and detected and reported here as diatomic I2. The mass transfer zone depths were estimated at 8 inches, somewhat deeper than the 2-5 inch range estimated for both silver aerogels and silver zeolites in prior deep-bed tests, which had lower NOx levels. The maximum iodine adsorption capacity and silver utilization for these higher NOx tests, at about 5-15% of the original sorbent mass, and about 12-35% of the total silver, respectively, were lower than for trends from prior silver aerogel and silver zeolite tests with lower NOx levels. Additional deep-bed testing and analyses are recommended to expand the database for organic iodide adsorption and increase the technical maturity if iodine adsorption processes.

  10. Prices, Productivity, and Investment: Assessing Financial Strategies in Higher Education. ASHE-ERIC Higher Education Reports. (United States)

    St. John, Edward P.

    This analysis critically examines the cost controversy in higher education with an eye to resolving the crisis which is currently serving to exacerbate public willingness to fund higher education. An introduction touches on the role and influence of political ideologies and offers a framework to be used throughout the analysis for critically…

  11. Diversity Leadership in Higher Education. ASHE Higher Education Report, Volume 32, Number 3 (United States)

    Aguirre, Adalberto, Jr., Ed.; Martinez, Ruben O., Ed.


    This monograph examines and discusses the context for diversity leadership roles and practices in higher education by using research and theoretical and applied literatures from a variety of fields, including the social sciences, business, and higher education. Framing the discussion on leadership in this monograph is the perspective that American…

  12. Ar-Ar_Redux: rigorous error propagation of 40Ar/39Ar data, including covariances (United States)

    Vermeesch, P.


    Rigorous data reduction and error propagation algorithms are needed to realise Earthtime's objective to improve the interlaboratory accuracy of 40Ar/39Ar dating to better than 1% and thereby facilitate the comparison and combination of the K-Ar and U-Pb chronometers. Ar-Ar_Redux is a new data reduction protocol and software program for 40Ar/39Ar geochronology which takes into account two previously underappreciated aspects of the method: 1. 40Ar/39Ar measurements are compositional dataIn its simplest form, the 40Ar/39Ar age equation can be written as: t = log(1+J [40Ar/39Ar-298.5636Ar/39Ar])/λ = log(1 + JR)/λ Where λ is the 40K decay constant and J is the irradiation parameter. The age t does not depend on the absolute abundances of the three argon isotopes but only on their relative ratios. Thus, the 36Ar, 39Ar and 40Ar abundances can be normalised to unity and plotted on a ternary diagram or 'simplex'. Argon isotopic data are therefore subject to the peculiar mathematics of 'compositional data', sensu Aitchison (1986, The Statistical Analysis of Compositional Data, Chapman & Hall). 2. Correlated errors are pervasive throughout the 40Ar/39Ar methodCurrent data reduction protocols for 40Ar/39Ar geochronology propagate the age uncertainty as follows: σ2(t) = [J2 σ2(R) + R2 σ2(J)] / [λ2 (1 + R J)], which implies zero covariance between R and J. In reality, however, significant error correlations are found in every step of the 40Ar/39Ar data acquisition and processing, in both single and multi collector instruments, during blank, interference and decay corrections, age calculation etc. Ar-Ar_Redux revisits every aspect of the 40Ar/39Ar method by casting the raw mass spectrometer data into a contingency table of logratios, which automatically keeps track of all covariances in a compositional context. Application of the method to real data reveals strong correlations (r2 of up to 0.9) between age measurements within a single irradiation batch. Propertly taking

  13. 40Ar/39Ar and U-Th-Pb dating of separated clasts from the Abee E4 chondrite (United States)

    Bogard, D.D.; Unruh, D.M.; Tatsumoto, M.


    Determinations of 40Ar/39Ar and U-Th-Pb are reported for three clasts from the Abee (E4) enstatite chondrite, which has been the object of extensive consortium investigations. The clasts give 40Ar/39Ar plateau ages and/or maximum ages of 4.5 Gy, whereas two of the clasts give average ages of 4.4 Gy. Within the range of 4.4-4.5 Gy these data do not resolve any possible age differences among the three clasts. 206Pb measured in these clasts is only ???1.5-2.5% radiogenic, which leads to relatively large uncertainties in the Pb isochron age and in the 207Pb/206Pb model ages. The Pb data indicate that the initial 207Pb/206Pb was no more than 0.08??0.07% higher than this ratio in Can??on Diablo troilite. The U-Th-Pb data are consistent with the interpretation that initial formation of these clasts occurred 4.58 Gy ago and that the clasts have since remained closed systems, but are contaminated with terrestrial Pb. The 40Ar/39Ar ages could be gas retention ages after clast formation or impact degassing ages. The thermal history of Abee deduced from Ar data appears consistent with that deduced from magnetic data, and suggests that various Abee components experienced separate histories until brecciation no later than 4.4 Gy ago, and experienced no appreciable subsequent heating. ?? 1983.

  14. The Entrepreneurial Domains of American Higher Education. ASHE Higher Education Report, Volume 34, Number 5 (United States)

    Mars, Matthew M.; Metcalf, Amy Scott


    This volume draws on a diverse set of literatures to represent the various ways in which entrepreneurship is understood in and applied to higher education. It provides a platform for debate for those considering applications of entrepreneurial principles to academic research and practices. Using academic entrepreneurship in the United States as…

  15. Strategies and Consequences. Managing the Costs in Higher Education. ASHE-ERIC Higher Education Report No. 8. (United States)

    Waggaman, John S.

    This report focuses on the need for better management of higher education resources in view of the rising costs and changing revenues now confronting higher education institutions in the United States. Rising costs and changing revenues are reflected in stagnating faculty salaries, a decline in enrollment, rising administrative and insurance…

  16. Interpretation of discordant 40Ar/39Ar age-spectra of mesozoic tholeiites from antarctica (United States)

    Fleck, R.J.; Sutter, J.F.; Elliot, D.H.


    Conventional K-Ar ages of tholeiitic basalts of the Ferrar Group in the central Transantarctic Mountains indicate significant loss of radiogenic 40Ar from this unit over much of its outcrop area. Argon loss varies inversely with amount of devitrified matrix in the basalts, which have not been thermally or tectonically disturbed since extrusion. 40Ar/19Ar age-spectra of these tholeiites are generally discordant and indicate significant inhomogeneity in the distribution of radiogenic 40Ar with respect to 39Ar, but are distinctly different from release patterns of thermally disturbed samples. Amounts of argon redistribution vary directly with amounts of devitrification and are reflected in progressive modification of the age spectra. A model of redistribution of radiogenic 40Ar by devitrification of originally glassy matrix is suggested that is consistent with disturbance of the conventional K-Ar systematics as well as the 40Ar/39Ar age-spectra. Samples with substantial redistribution but minor loss of radiogenic argon yield age spectra whose apparent ages decrease from low-temperature to high-temperature steps, similar to those reported for some lunar basalts, breccias, and soils. Modification of all the age spectra is attributed to redistribution of radiogenic 40Ar during progressive devitrification, although 39Ar-recoil effects suggested by Turner and Cadogan (1974) may be a factor in some cases. Where devitrification involves most potassium sites within the basalt, 40Ar/39Ar age-plateaux may be formed that have no geologic significance. ?? 1977.

  17. Standards of the Instructional Performances in Higher-Education Institutions; Conformity to Quality Requirements: Ar-Rass College of Science and Arts--Model (United States)

    Alharbi, Jobier Suliman


    The paper studies the standard of the educational process in higher institutions and the extent of compliance with quality requirements. The college of science and Arts, Qassim University is considered as a case study. In order to assure the success of the study there are a questionnaire is designed and prepared for this purpose. It contains main…

  18. Strategic Reporting Tool: Balanced Scorecards in Higher Education (United States)

    Lyddon, Jan W.; McComb, Bruce E.


    In this toolbox article, the authors describe the recommended steps for creating a community college balanced scorecard that measures and reports on key performance indicators based on targets and signal values to end-users, college constituents and external stakeholders. Based on extensive experience in the field, the authors provide a…

  19. ArArCALC—software for 40Ar/ 39Ar age calculations (United States)

    Koppers, Anthony A. P.


    ArArCALC is a Microsoft Excel ® 97-2000-XP application for performing calculations in 40Ar/ 39Ar geochronology. It is coded in Visual Basic for Applications and can be used under the Windows ® 95/98/NT/2000/ME/XP operating systems. ArArCALC provides an easy-to-use graphical interface for the calculation of age plateaus, total fusion ages and isochrons following the regression of 40Ar/ 39Ar mass spectrometry data. Results are stored in single Excel workbooks including nine different data tables and four different diagrams. Analytical, internal and external errors are calculated based on error propagation of all input parameters, analytical data and applied corrections. Finally, the age calculation results can be recalibrated with reference to the primary K-Ar standards (e.g. GA-1550, MMhb-1) in order to obtain more consistent absolute40Ar/ 39Ar age determinations. ArArCALC is distributed as freeware.

  20. Danish MMR vaccination coverage is considerably higher than reported. (United States)

    Holt, Nanna; Mygind, Anna; Bro, Flemming


    The Danish childhood vaccination programme offers protection against measles, mumps, and rubella (MMR). Nevertheless, many children appear to be unvaccinated according to the national registers. The aim of this study was to estimate the MMR1 vaccination coverage based on a medical record review of children whose vaccination status is negative according to the register-based data. We conducted a cross-sectional study of 19 randomly selected general practices in the Central Denmark Region including 1,712 children aged 18-42 months. The practices received a registration form listing children with a negative MMR1 vaccination status in the register-based data. The general practices then validated the children's vaccination status by medical record review. In total, 94% of the children had been vaccinated according to the medical records in general practice compared with 86% according to the register-based data. Of the 246 children who were unvaccinated according to the register-based data, 135 (55%) had been vaccinated according to the medical records. This discrepancy was due mainly to administrative reimbursement errors. The MMR1 vaccination coverage in Denmark seems to be considerably higher than reflected in national registers. Using medical record review to re-assess the vaccination status revealed that most of the supposedly unvaccinated children had, in fact, been vaccinated. The Danish Research Foundation for General Practice and the General Practitioners' Foundation for Education and Development. not relevant.

  1. Construction of higher dimensional charged gravastars: a survey report

    CERN Document Server

    Ghosh, S; Guha, B K; Ray, Saibal


    We explore possibility to find out a new model of gravastars in the extended $D$-dimensional Einstein-Maxwell spacetime. The class of solutions as obtained by Mazur and Mottola of a neutral gravastar~\\cite{Mazur2001,Mazur2004} have been observed as an alternative to $D$-dimensional versions of the Schwarzschild-Tangherlini black hole. To tackle the spherical system in a convenient way we have configured that the gravastar consists of three distinct regions with different equations of state as follows: [I] Interior region $0 \\leq r < r_1$,~$\\rho = -p$, [II] Thin shell region $r_1 \\leq r < r_2$,~$\\rho = p$, and [III] Exterior region $r_2 < r$,~$\\rho = p =0$. The outer region of this gravastar model therefore corresponds to a higher dimensional Reissner-Nordstr{\\"o}m black hole. In connection to this junction conditions are provided and therefore we have formulated mass and the related Equation of State of the gravastar. It has been shown that the model satisfies all the requirements of the physical fea...

  2. Re-Evaluation of Ar-39 - Ar-40 Ages for Apollo Lunar Rocks 15415 and 60015 (United States)

    Park, J.; Nyquist, L. E.; Bogard, D. D.; Garrison, D. H.; Shih, C.-Y.


    We re-analyzed 39Ar-40Ar ages of Apollo lunar highland samples 15415 and 60015, two ferroan anorthosites analyzed previously in the 1970 s, with a more detailed approach and with revised decay constants. From these samples we carefully prepared 100-200 mesh mineral separates for analysis at the Noble Gas Laboratory at NASA-Johnson Space Center. The Ar-39-Ar-40 age spectra for 15415 yielded an age of 3851 +/- 38 Ma with 33-99% of Ar39 release, roughly in agreement with previously reported Ar-Ar ages. For 60015, we obtained an age of 3584 +/- 152 Ma in 23-98% of Ar39 release, also in agreement with previously reported Ar-Ar ages of approximately 3.5 Ga. Highland anorthosites like these are believed by many to be the original crust of the moon, formed by plagioclase floatation atop a magma ocean, however the Ar-Ar ages of 15415 and 60015 are considerably younger than lunar crust formation. By contrast, recently recovered lunar anorthosites such as Dhofar 489, Dhofar 908, and Yamato 86032 yield older Ar-Ar ages, up to 4.35 Ga, much closer to time of formation of the lunar crust. It follows that the Ar-Ar ages of the Apollo samples must have been reset by secondary heating, and that this heating affected highland anorthosites at both the Apollo 15 and Apollo 16 landing sites but did not affect lunar highland meteorites. One obvious consideration is that while the Apollo samples were collected from the near side of the moon, these lunar meteorites are thought to have originated from the lunar far side

  3. Atmospheric pressure plasma produced inside a closed package by a dielectric barrier discharge in Ar/CO2 for bacterial inactivation of biological samples

    DEFF Research Database (Denmark)

    Chiper, Alina Silvia; Chen, Weifeng; Mejlholm, Ole


    The generation and evaluation of a dielectric barrier discharge produced inside a closed package made of a commercially available packaging film and filled with gas mixtures of Ar/CO2 at atmospheric pressure is reported. The discharge parameters were analysed by electrical measurements and optical...... times higher in the Ar/CO2 plasma compared with an Ar plasma. The efficiency of the produced plasma for the inactivation of bacteria on food inside the closed package was investigated....

  4. MC carbide structures in M(lc2)ar-M247. M.S. Thesis - Final Report (United States)

    Wawro, S. W.


    The morphologies and distribution of the MC carbides in Mar-M247 ingot stock and castings were investigated using metallographic, X-ray diffraction and energy-dispersive X-ray analysis techniques. The MC carbides were found to form script structures during solidification. The script structures were composed of three distinct parts. The central cores and elongated arms of the MC carbide script structures had compositions (Ti, Cr, Hf, Ta, W)C and lattice parameters of 4.39 A. The elongated script arms terminated in enlarged, angular "heads". The heads had compositions (Ti, Hf, Ta, W)C and lattice parameters of approximately 4.50 A. The heads had a higher Hf content than the cores and arms. The size of the script structures, as well as the relative amount of head-type to core and arm-type MC carbide, was found to be determined by solidification conditions. No carryover of the MC carbides from the ingot stock to the remelted and cast material was observed.

  5. Reducing barriers to energy efficiency in the German higher education sector. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Schleich, J.; Boede, U.


    This report describes the empirical research into barriers to energy efficiency in the German higher education (HE) sector. It is one of nine such reports in the BARRIERS project. The report contains description and analysis of six case studies of energy management in German universities. The results are analysed using the theoretical framework developed for the BARRIERS project (Sorrell et al., 2000). The report also provides brief recommendations on how these barriers to the rational use of energy (RUE) may be overcome and how energy efficiency within the sector may be improved. The results of the study for the higher education sector in Germany are summarised in this executive summary under the following headings: - Characterising the higher education sector; - Case studies of energy management in the German higher education sector; - Evidence of barriers in the German higher education sector; - The role of energy service companies in the higher education sector; - Policy implications. (orig.)

  6. The Supply of Part-Time Higher Education in the UK. Research Report (United States)

    Callender, Claire; Birkbeck, Anne Jamieson; Mason, Geoff


    This report explores the supply of part-time higher education in the UK, with particular consideration to the study of part-time undergraduate provision in England. It is the final publication in the series of reports on individual student markets that were commissioned by Universities UK following the publication of the reports on the Future size…

  7. ars1, an Arabidopsis mutant exhibiting increased tolerance to arsenate and increased phosphate uptake. (United States)

    Lee, David A; Chen, Alice; Schroeder, Julian I


    Arsenic is one of the most toxic pollutants at contaminated sites, yet little is known about the mechanisms by which certain plants survive exposure to high arsenic levels. To gain insight into the mechanisms of arsenic tolerance in plants, we developed a genetic screen to isolate Arabidopsis thaliana mutants with altered tolerance to arsenic. We report here on the isolation of a mutant arsenic resisant 1 (ars1) with increased tolerance to arsenate. ars1 germinates and develops under conditions that completely inhibit growth of wild-type plants and shows a semi-dominant arsenic resistance phenotype. ars1 accumulates levels of arsenic similar to that accumulated by wild-type plants, suggesting that ars1 plants have an increased ability to detoxify arsenate. However, ars1 plants produce phytochelatin levels similar to levels produced by the wild type, and the enhanced resistance of ars1 is not abolished by the gamma-glutamylcysteine synthetase inhibitor l-buthionine sulfoxime (BSO). Furthermore, ars1 plants do not show resistance to arsenite or other toxic metals such as cadmium and chromium. However, ars1 plants do show a higher rate of phosphate uptake than that shown by wild-type plants, and wild-type plants grown with an excess of phosphate show increased tolerance to arsenate. Traditional models of arsenate tolerance in plants are based on the suppression of phosphate uptake pathways and consequently on the reduced uptake of arsenate. Our data suggest that arsenate tolerance in ars1 could be due to a new mechanism mediated by increased phosphate uptake in ars1. Models discussing how increased phosphate uptake could contribute to arsenate tolerance are discussed.

  8. Comparative 40Ar/39Ar and K-Ar dating of illite-type clay minerals: A tentative explanation for age identities and differences (United States)

    Clauer, Norbert; Zwingmann, Horst; Liewig, Nicole; Wendling, Raymond


    The 40K/40Ar (K-Ar) and 40Ar/39Ar dating methods are applied here to the same, very small, micrometric illite-type particles that crystallized under low-temperature (samples with a total of fifteen size fractions from advantages, such as the plateaus obtained by incremental step heating of the various size fractions, even if not translatable straight as ages of the illite populations; they allow identification of two generations of authigenic illite that formed at about 200 and 175 Ma, and one detrital generation. However, 40Ar/39Ar dating of clay minerals remains challenging as technical factors, such as the non-standardized encapsulation, may have potential unexpected effects. Both dating methods have their limitations: (1) K-Ar dating requires relatively large samples (ca. 10-20 mg) incurring potential sample homogeneity problems, with two aliquots required for K and Ar analysis for an age determination, also inducing a higher analytical uncertainty; (2) an identified drawback of 40Ar/39Ar dating is Ar recoil and therefore potential loss that occurs during neutronic creation of 39Ar from 39K, mostly in the finer mineral particles. If all the recoiled 39Ar is redistributed into adjacent grains/minerals, the final 40Ar/39Ar age of the analyzed size fraction remains theoretically identical, but it is not systematic in clay-type material. The finest grain sizes (e.g., convenient and straightforward use supported by a standardized and well-controlled technical approach. The present comparison of the two Ar-dating methods as applied to clay material shows that neither method is presently outdated, and that they are even of reciprocal use. Both methods have distinct application fields in clay geochronology and complementary application fields in clay crystallography.

  9. Ars Himera / Irina Lobanova

    Index Scriptorium Estoniae

    Lobanova, Irina


    Iseloomustatakse praegust aega ja moodsat kunsti: valitseb vastutustundetus ja ebainimlikkus. Näited - professor von Hageni "Korpwelten" ja uusim kunstinähtus Ars Chimaera - eksponeerimise eesmärgil surrogaatsete elusolendite saamise kunst

  10. ArDroneXT - Ar.Drone 2 eXTension for swarming and service hosting


    Autefage, Vincent; Chaumette, Serge


    This is an Operating System Setup Guide.; This report explains how to upgrade an Ar.Drone 2 for swarming and services hosting. In other words, it gives the technical information required to easily create a swarm of Ar.Drone 2 sharing a Wi-Fi network. Moreover, it describes the process to install new services and applications on the drone.

  11. A Refined Astronomically Calibrated 40Ar/39Ar Age for Fish Canyon Sanidine

    DEFF Research Database (Denmark)

    Rivera, Tiffany; Storey, Michael; Zeeden, Christian


    Intercalibration between the astronomical and radio-isotopic dating methods provides a means to improving accuracy and reducing uncertainty of an integrated, multi-chronometer geologic timescale. Here we report a high-precision 40Ar/39Ar age for the Fish Canyon sanidine (FCs) neutron fluence...

  12. A refined astronomically calibrated 40Ar/39Ar age for Fish Canyon sanidine

    NARCIS (Netherlands)

    Rivera, T.A.; Storey, M.; Zeeden, C.; Hilgen, F.J.; Kuiper, K.


    Intercalibration between the astronomical and radio-isotopic dating methods provides a means to improving accuracy and reducing uncertainty of an integrated, multi-chronometer geologic timescale. Here we report a high-precision 40Ar/39Ar age for the FishCanyon sanidine (FCs) neutron fluence monitor,

  13. Higher Education in Kentucky. Final Report of the SCR 30 Study Committee. Program Evaluation. Research Report No. 222. (United States)

    Fiala, Joseph; And Others

    A report on higher education in Kentucky is presented, with attention to governance, funding, tuition, financial aid, staffing and salary comparisons for administrators and faculty, enrollment, degree production, cooperation, and quality issues. The statutory organization of the Kentucky Council on Higher Education is specified, along with the…

  14. Eurekan deformation on Prins Karls Forland, Svalbard - new insights from Ar40/Ar39 muscovite dating (United States)

    Faehnrich, Karol; Schneider, David; Manecki, Maciej; Czerny, Jerzy; Myhre, Per Inge; Majka, Jarosław; Kośmińska, Karolina; Barnes, Christopher; Maraszewska, Maria


    Eurekan deformation has been proven to be a complex sequence of tectonic episodes, dominated by compression in the Circum Arctic region. It was associated with early Cenozoic collision of Eurasia, North America and Greenland plates producing fold-thrust belt style of deformation. Timing of this enigmatic event has not yet been extensively resolved by radiometric dating (Piepjohn et al. 2016, Journal of the Geological Society, 173(6), 1007-1024). Reinhardt et al. (2013, Z. Dt. Ges. Geowiss., 164 (1), 131-147) dated syn-tectonic volcanic ashes at c. 60 Ma and 54 Ma on Ellesmere Island, Canada. Tagner et al. (2011, Earth and Planetary Science Letters, 303(3), 203-214) interpreted c. 49-47 Ma 40Ar/39Ar ages on trachyte flows in northern Greenland as peak compression during the Eurekan event. On Svalbard, Tessensohn et al. (2001, Geologisches Jahrbuch, B 91, 83-104) reported K/Ar whole rock ages ranging from c. 67 to 49 Ma for the slates from Svartfjella-Eidembukta-Daudmannsodden Lineament. Bentonite layers in the Central Tertiary Basin are as young as c. 56 Ma (Charles et al. 2011, Geochem. Geophys. Geosyst., 12, 1-19), predating latest deformation. Moreover, Barnes et al (2017, in prep.) applied (U-Th)/He thermochronology along the western margin of Svalbard and resolved Early to Middle Eocene heating, likely documenting burial related to thrusting. Here we present new results from 40Ar/39Ar muscovite dating of ductile to brittle shear zone on Prins Karls Forland, Svalbard, indicating Eurekan age of thrusting. Prins Karls Forland is dominated by Neoproterozoic siliciclastic metasediments (comprising Caledonian basement) regionally metamorphosed to greenschist facies conditions. A ˜1 km wide ductile to brittle shear zone (the Bouréefjellet shear zone) separates the amphibolite facies Pinkie Unit from the lower grade upper structural unit, the Grampianfjella Formation (Faehnrich et al. 2016, EGU 2016). The age of the amphibolite facies metamorphism (c. 370-355 Ma

  15. A Methodology for Sustainability Evaluation and Reporting in Higher Education Institutions (United States)

    Madeira, Ana C.; Carravilla, Maria Antonia; Oliveira, Jose F.; Costa, Carlos A. V.


    The purpose of this paper is to present a methodology that allows higher education institutions (HEIs) to promote, to evaluate and to report on sustainability. The ultimate goal of the afore-mentioned methodology is to help HEIs achieve sustainability. First, a model entitled Sustainability in Higher Education Institutions (SusHEI) that generally…

  16. Sources of Fluctuations and Growth of Investment in Higher Education. Final Report. (United States)

    McMahon, Walter W.

    A study was undertaken to apply family investment techniques and public expenditure analysis to problems faced in higher education, treating expenditures for higher education as an investment in human resources. The report is addressed to economists, policy makers, and educators and students, and is both technical and nontechnical in its various…

  17. A Management Control Perspective of Sustainability Reporting in Higher Education: In Search of a Holistic View


    Ceulemans, Kim; Van Caillie, Didier; Molderez, Ingrid; Van Liedekerke, Luc


    Higher education institutions have been actively attempting to integrate sustainability in their curricula, research, operations, and outreach activities over the last decades. Despite the efforts undertaken, it is currently still challenging for their internal and external stakeholders to assess an institution’s sustainability-related activities and the extent of their implementation within the different activities of higher education. Since sustainability reporting in higher ...




  19. Addressing the Declining Productivity of Higher Education Using Cost-Effectiveness Analysis. Stretching the Higher Education Dollar. Special Report 2 (United States)

    Harris, Douglas N.


    Higher education productivity, as measured by academic degrees granted by American colleges and universities, is declining. Since the early 1990s, real expenditures on higher education have grown by more than 25 percent, now amounting to 2.9 percent of US gross domestic product (GDP)--greater than the percentage of GDP spent on higher education in…

  20. Addressing the Declining Productivity of Higher Education Using Cost-Effectiveness Analysis. Stretching the Higher Education Dollar. Special Report 2 (United States)

    Harris, Douglas N.


    Higher education productivity, as measured by academic degrees granted by American colleges and universities, is declining. Since the early 1990s, real expenditures on higher education have grown by more than 25 percent, now amounting to 2.9 percent of US gross domestic product (GDP)--greater than the percentage of GDP spent on higher education in…

  1. Ar + NO microwave plasmas for Escherichia coli sterilization

    Energy Technology Data Exchange (ETDEWEB)

    Hueso, Jose L; Rico, Victor J; Cotrino, Jose; Gonzalez-Elipe, Agustin R [Instituto de Ciencia de Materiales de Sevilla, Centro Mixto CSIC-Universidad de Sevilla, Centro de Investigaciones Cientificas Isla de la Cartuja, Avda. Americo Vespucio 49, 41092 Sevilla (Spain); Frias, Jose E [Instituto de BioquImica Vegetal y FotosIntesis (IBVF-CSIC). Centro de Investigaciones CientIficas Isla de la Cartuja. Avda Americo Vespucio, 49, 41092 Sevilla (Spain)], E-mail:


    Ar + NO microwave discharges are used for sterilization and the results are compared with additional experiments with Ar, O{sub 2} and N{sub 2}-O{sub 2} plasma mixtures. The NO{sup *} species produced in the Ar-NO mixtures remain up to long distances from the source, thus improving the sterilization efficiency of the process. E. coli individuals exposed to the Ar + NO plasma undergo morphological damage and cell lysis. Combined effects of etching (by O{sup *} and Ar{sup *} species) and UV radiation (from deactivation of NO{sup *} species) are responsible for the higher activity found for this plasma mixture. (fast track communication)

  2. Differential AR algorithm for packet delay prediction

    Institute of Scientific and Technical Information of China (English)


    Different delay prediction algorithms have been applied in multimedia communication, among which linear prediction is attractive because of its low complexity. AR (auto regressive) algorithm is a traditional one with low computation cost, while NLMS (normalize least mean square) algorithm is more precise. In this paper, referring to ARIMA (auto regression integrated with moving averages) model, a differential AR algorithm (DIAR) is proposed based on the analyses of both AR and NLMS algorithms. The prediction precision of the new algorithm is about 5-10 db higher than that of the AR algorithm without increasing the computation complexity.Compared with NLMS algorithm, its precision slightly improves by 0.1 db on average, but the algorithm complexity reduces more than 90%. Our simulation and tests also demonstrate that this method improves the performance of the average end-to-end delay and packet loss ratio significantly.

  3. PF-AR upgrading project

    CERN Document Server

    Kasuga, T


    The upgrading project of the dedicated pulse X-ray source PF-AR has been completed by the end of the 2001 fiscal year. Machine commissioning exclusively using the injector linac was successfully accomplished in the beginning of January 2002. After fine tuning of the machine and cleaning of the vacuum system with the beams from the middle of January to the middle of March, routine operation for users has begun in April. The historical details, commissioning and results of the project are reported. (author)

  4. 39Ar-40Ar Dating of Eucrites and Howardites and the Early Bombardment of the HED Parent Body (United States)

    Bogard, D. D.; Garrison, D. H.


    Eucrite and howardite meteorites are impact breccias from the HED parent body, which may have been the 520 km diameter asteroid 4 Vesta [1]. Using textural and compositional information on pyroxenes from individual clasts, [2] proposed a classification scheme based on the degree of thermal metamorphism exhibited by nearly all eucrites. In the highest grade, chemical zoning of pyroxenes has been erased and areas of impact melt sometimes have been produced. Thus, HED meteorites appear to be products of an early bombardment history of the inner portion of the main asteroid belt, just as most lunar highland rocks are products of early impact bombardment of the Moon. To determine the time period for major impacts on the HED parent body, we have measured ^39Ar-^40Ar ages for a large number of eucritic clasts from eucrites and howardites. All of these samples indicate partial to complete K-Ar chronometer resetting by several different impact events much more recent than eucrite crystallization times of ~4.45-4.55 Ga. For example, the ^39Ar- ^40Ar ages of paired eucrites Y-791186 and Y-792510 were essentially entirely reset 3.45 +- 0.05 Ga ago. A clast from Millbillillie gave a slightly older ^39Ar-^40Ar resetting age of 3.55 +- 0.02 Ga. (A similar degassing age of 3.5 +- 0.1 Ga was recently reported for Stannern [3]). Clast EET87531,21 gave a degassing age of 3.83 +- 0.05 Ga; clast EET82600 suggests an age of 3.89 +- 0.07 Ga; a clast from LEW85300 suggests a similar age to these. Several eucritic clasts gave ^39Ar-^40Ar degassing ages near 4.0 Ga. These include two clasts from EET87509 (,71 at 4.00 +- 0.05 Ga and ,74 at 3.93 +- 0.06 Ga), EET87509,24 (4.07 +- 0.02 Ga), Y-792769,68 (3.99 +- 0.04 Ga), and Y-790020,5 (4.03 +- 0.03 Ga). Clast and matrix samples from Y-75011 gave slightly different ages of 3.98 +- 0.03 Ga and 3.94 +- 0.04 Ga. Analyses of several additional eucritic clasts gave less well-defined ^39Ar-^40Ar release spectra that are consistent with this range in

  5. Financing Higher Education in Francophone West Africa. An EDI Policy Seminar Report, Number 12. (United States)

    Ransom, Angela

    Meetings were held in Senegal in 1985, in Cote d'Ivoire in 1986, and in Zimbabwe in 1987, concerning the current state of higher education finance in Africa, the structure of unit costs, and the role of development assistance agencies and other sources of financial support. Reports are presented concerning the macroeconomic perspective, internal…

  6. Unilateral dysphotopsia after bilateral intraocular lens implantation using the AR40e IOL model: case report Disfotopsia unilateral após implante bilateral de lente intra-ocular modelo AR40e: relato de caso


    Frederico França Marques; Daniela Meira Villano Marques


    The authors report a recent complication during the postoperative period of cataract surgery. A patient was submitted to cataract surgery in both eyes with IOL implantation (Sensar®) inside the capsular bag. The postoperative period of right eye was uneventful, however, in the left eye the patient noted a dark shadow at the temporal visual field at the first postoperative week. This diagnosis was confirmed with the presence of a temporal scotoma revealed by the computerized visual field (firs...

  7. AR-Signaling in Human Malignancies: Prostate Cancer and Beyond

    Directory of Open Access Journals (Sweden)

    Michael T. Schweizer


    Full Text Available In the 1940s Charles Huggins reported remarkable palliative benefits following surgical castration in men with advanced prostate cancer, and since then the androgen receptor (AR has remained the main therapeutic target in this disease. Over the past couple of decades, our understanding of AR-signaling biology has dramatically improved, and it has become apparent that the AR can modulate a number of other well-described oncogenic signaling pathways. Not surprisingly, mounting preclinical and epidemiologic data now supports a role for AR-signaling in promoting the growth and progression of several cancers other than prostate, and early phase clinical trials have documented preliminary signs of efficacy when AR-signaling inhibitors are used in several of these malignancies. In this article, we provide an overview of the evidence supporting the use of AR-directed therapies in prostate as well as other cancers, with an emphasis on the rationale for targeting AR-signaling across tumor types.

  8. Identification and analysis of ARS function of six plant MARs

    Institute of Scientific and Technical Information of China (English)

    LI Hong; YANG Yutao; ZHANG Kewei; ZHENG Chengchao


    Six plant MARs isolated from tobacco and Arabdiposis were investigated for their ARS activity in yeast.The results showed that among the six plant MARs, only TM1 and AM4 had strong ARS activity which was almost the same as that of ARS from yeast chromosome. In order to further identify the core region of the two MARs for the ARS activity, a series of subclones were created by PCR strategy,and the corresponding subclones were designated as TM1-1,TM1-2, TM1-3, AM4-1, AM4-2 and AM4-3, respectively. Our studies revealed that TM1-3 and AM4-3 not only had higher ARS activity, but also displayed higher transformation frequency, plasmid stability and growth rate compared to their intact MARs, TM1 and AM4. These data present an important clue for further elucidating the relationship between MAR and ARS.

  9. Public Policies, Prices, and Productivity in American Higher Education. Stretching the Higher Education Dollar. Special Report 3 (United States)

    Hauptman, Arthur M.


    Rapid increases in what colleges charge and what they spend per student have been and remain one of the most controversial aspects of American higher education. Tuition, fees, and other college charges have increased in both the public and private sectors at more than twice the rate of inflation for over a quarter century. Trends over time in what…

  10. Public Policies, Prices, and Productivity in American Higher Education. Stretching the Higher Education Dollar. Special Report 3 (United States)

    Hauptman, Arthur M.


    Rapid increases in what colleges charge and what they spend per student have been and remain one of the most controversial aspects of American higher education. Tuition, fees, and other college charges have increased in both the public and private sectors at more than twice the rate of inflation for over a quarter century. Trends over time in what…

  11. Blueprint or Blue Remembered Hills? The Relevance of the Robbins Report to the Present Reforms of Higher Education. (United States)

    Scott, Peter


    Presents opposing interpretations of the Robbins Report, stating that British higher education is still guided by its principles. Examines the report's influence on the size and shape of the higher education system, the character of higher education regarding teaching and research, and higher education's place in modern society. (GEA)

  12. Blueprint or Blue Remembered Hills? The Relevance of the Robbins Report to the Present Reforms of Higher Education. (United States)

    Scott, Peter


    Presents opposing interpretations of the Robbins Report, stating that British higher education is still guided by its principles. Examines the report's influence on the size and shape of the higher education system, the character of higher education regarding teaching and research, and higher education's place in modern society. (GEA)

  13. Ramon Llull's Ars Magna

    DEFF Research Database (Denmark)

    Jensen, Thessa


    intelligence and knowledge representation, which seeks to formalise language and knowledge in a way which can be translated into a computer program. And as Fidora’s and Sierra’s [4] anthology Ramon Llull: From the Ars Magna to Artificial Intelligence shows, Llull’s influence and relevance is profound in today......’s work on topics ranging from conceptual graphs and logical analysis, social choice theory and adaptive reasoning to Llull’s influence on Peirce’s pragmatic thinking. Llull is important, even now, on a whole other level. His ethical considera-tions when he wanted to convince people of the one true faith...... Llull: From the Ars Magna to Artificial Intelligence. Barcelona: Artificial Intelligence Research Institute (2011)....

  14. Combined K-Ar and 40Ar/39Ar dating of the upper Jaramillo reversal (United States)

    Guillou, Herve; Carracedo, Juan Carlos; Kissel, Catherine; Laj, Carlo; Nomade, Sebastien; Perez Torrado, Francisco Jose; Rodriguez Gonzalez, Alejandro; Wandres, Camille


    The Jaramillo subchron was first evidenced in 1966 (Doell and Dalrymple) through the Rhyolotic domes of the Valles Caldera, New Mexico (USA). 40Ar/39Ar studies achieved by Spell et McDougall (1992), Spell et Harrison (1993), Izett and Obradovich (1994) and Singer et al. (1994) defined the base of this subchron at 1053±6 ka, and the ceiling at 986±5 ka. Channell et al. (2009) delimited the age of the Jaramillo subchron by astronomic calibration (base 1071 ka, top 990 ka). To provide additional absolute ages on this geomagnetic period, which is critical to improve our knowledge of the earth magnetic field behaviour, we have carried out a study combining paleomagnetism and isotopic dating of a lava sequence from Tenerife island. This sequence of basaltic lava flows is some 500 m thick. The first 400 m present, based on field magnetometer measurements, normal polarity lavas, with dykes of normal and reverse polarity, passing at the top to reverse polarity lavas. Preliminary K-Ar ages bracketed this sequence between 1018 ± 18 ka and 978 ± 17 ka. Therefore, the upper Jaramillo reversal at least appeared to be potentially recorded in this sequence. A more detailed paleomagnetic study was then carried out to more precisely delimit the reversal itself (see Laj et al., session EMRP3.4). We have undertaken 40Ar/39Ar incremental heating and unspiked K-Ar experiments on groundmass from four transitionally magnetized flows. The first transitional flow is K-Ar dated at 993 ± 18 ka and 40Ar/39Ar dated at 991 ± 13 ka, the second at 981 ± 17 ka (K-Ar) and 1000 ± 13 ka (40Ar/39Ar), the third at 950 ± 17 ka (K-Ar) and 1000 ± 8 ka (40Ar/39Ar) and the fourth at 984 ± 17 ka (K-Ar) and 977 ± 12 (40Ar/39Ar). 40Ar/39Ar ages and K-Ar ages (relative to FCT 28.02 Ma) are indistinguishable at 2σ. The age of the upper boundary of the Jaramillo event calculated combining 40Ar/39Ar ages and K-Ar ages is 992 ± 6 ka, in agreement with previous estimates.

  15. Ars Electronica tulekul / Rael Artel

    Index Scriptorium Estoniae

    Artel, Rael, 1980-


    6.-11. IX toimub Austrias Linzis "Ars Electronica" festival, mille teema on "Code - The Language of Our Time". Festivali kavast, osalejatest, ava-performance'ist "Europe - A Symphonic Vision", näitusest "Cyberarts 2003. Prix Ars Electronica"

  16. Ars Electronica tulekul / Rael Artel

    Index Scriptorium Estoniae

    Artel, Rael, 1980-


    6.-11. IX toimub Austrias Linzis "Ars Electronica" festival, mille teema on "Code - The Language of Our Time". Festivali kavast, osalejatest, ava-performance'ist "Europe - A Symphonic Vision", näitusest "Cyberarts 2003. Prix Ars Electronica"

  17. Photoionization of Ar VIII (United States)

    Liang, Liang; Jiang, Wen-xian; Zhou, Chao


    The photoionization cross section, energy levels and widths of 22 Rydberg series (in the autoionization region) for Na-like Ar VIII were investigated by using of R-matrix method. The relativistic distorted-wave method is used to calculate the radial functions, and QB method of Quigly-Berrington [Quigley et al. 1998] is employed to calculate the resonance levels and widths. We have identified the formant in the figure of the photoionization cross section.

  18. Unilateral dysphotopsia after bilateral intraocular lens implantation using the AR40e IOL model: case report Disfotopsia unilateral após implante bilateral de lente intra-ocular modelo AR40e: relato de caso

    Directory of Open Access Journals (Sweden)

    Frederico França Marques


    Full Text Available The authors report a recent complication during the postoperative period of cataract surgery. A patient was submitted to cataract surgery in both eyes with IOL implantation (Sensar® inside the capsular bag. The postoperative period of right eye was uneventful, however, in the left eye the patient noted a dark shadow at the temporal visual field at the first postoperative week. This diagnosis was confirmed with the presence of a temporal scotoma revealed by the computerized visual field (first reported in this study and also reducing the pupil area with miotic drops. The treatment of this complication was performed by using brimonidine tartrate and after 6 months this symptom completely disappeared as confirmed by the computerized visual field. The treatment should be based on reducing the pupil area with miotic drops and we also recommend to observe these cases until the 6th postoperative month before indicating an IOL exchange since the capsular edge that overlaps the IOL may opacify creating an optical barrier reducing or eliminating negative dysphotopsia.Os autores relatam uma complicação no período pós-operatório relativamente recente na cirurgia de catarata. Trata-se de paciente que foi submetido à cirurgia de catarata bilateral não simultânea com implante sacular da lente intra-ocular (Sensar®. O pós-operatório do olho direito evoluiu sem nenhuma queixa, entretanto, no olho esquerdo o paciente referiu a presença de uma sombra em campo visual temporal na primeira semana de pós-operatório sendo diagnosticado disfotopsia negativa após exclusão de outras causas oculares, principalmente retinianas. Este diagnóstico foi confirmado com a presença de um escotoma temporal na campimetria visual computadorizada (relatado na literatura pela primeira vez neste estudo e também com a redução medicamentosa do tamanho da pupila. Seu tratamento foi realizado com a administração de tartarato de brimonidina e após 6 meses o sintoma


    Directory of Open Access Journals (Sweden)



    Full Text Available Stemming is a main step used to process textual data. It is usually used in several types of applications such as: text mining, information retrieval (IR, and natural language processing (NLP. A major task in stemming is to standardize words; which can be achieved by reducing each word to its base (root or stem. Arabic stemming is not an easy task. Unlike other languages, Arabic language is a highly inflected language, since it uses many inflectional forms. Researchers are divided on the benefit of using stemming in fields of IR, NLP...etc., since in Arabic the morphological variants of a certain word are not always semantically related. The aim of this paper is to design and implement a new Arabic light stemmer (ARS which is not based on Arabic root patterns. Instead, it depends on well defined mathematical rules and several relations between letters. A series of tests were conducted on ARS stemmer to compare its effectiveness with the effectiveness of two other Arabic stemmers. Test shows clearly the effectiveness superiority of ARS compared to effectiveness of these two Arabic stemmers.

  20. Tracking fluid action in Little Sark Pluton (Channel Islands, UK): a UV laserprobe Ar/Ar study of excess 40Ar (United States)

    Schwenzer, S. P.; Schwanethal, J.; Tindle, A. G.; Kelley, S. P.; Sherlock, S. C.


    . At least one fluid appears to have been a chlorine-rich brine with excess 40Ar, the presence of excess argon is confirmed by very high apparent ages in quartz. A second end member was a chlorine-poor fluid with higher 36Ar contents and associated with lower apparent ages. The combination of observed mineralogical changes and spatially resolved Ar-Ar data indicate the pathways of the fluids, and demonstrates the power of high spatial resolution Ar-Ar dating to unravel a succession of geologic events.

  1. Behavior of argon gas release from manganese oxide minerals as revealed by 40Ar/39Ar laser incremental heating analysis

    Institute of Scientific and Technical Information of China (English)


    Manganese oxides in association with paleo- weathering may provide significant insights into the multiple factors affecting the formation and evolution of weathering profiles, such as temperature, precipitation, and biodiversity. Laser probe step-heating analysis of supergene hollandite and cryptomelane samples collected from central Queensland, Australia, yield well-defined plateaus andconsistent isochron ages, confirming the feasibility dating very-fined supergene manganese oxides by 40Ar/39Ar technique. Two distinct structural sites hostingAr isotopes can be identified in light of their degassing behaviors obtained byincremental heating analyses. The first site, releasing its gas fraction at thelaser power 0.2-0.4 W, yields primarily 40Aratm, 38Aratm, and 36Aratm (atmospheric Ar isotopes). The second sites yield predominantly 40Ar* (radiogenic 40Ar),39ArK, and 38ArK (nucleogenic components), at ~0.5-1.0 W. There is no significant Ar gas released at the laser power higher than 1.0 W, indicating the breakdown of the tunnel sites hosting the radiogenic and nucleogenic components. The excellent match between the degassing behaviors of 40Ar*, 39ArK, and 38ArK suggests that these isotopes occupy the same crystallographic sites and that 39ArK lossfrom the tunnel site by recoil during neutron irradiation and/or bake-out procedure preceding isotopic analysis does not occur. Present investigation supports that neither the overwhelming atmospheric 40Ar nor the very-fined nature of the supergene manganese oxides poses problems in extracting meaningful weathering geochronological information by analyzing supergene manganese oxides minerals.

  2. Ar-Ar Impact Heating Ages of Eucrites and Timing of the LHB (United States)

    Bogard, Donald; Garrison, Daniel


    Eucrites and howardites, more than most meteorite types, show extensive impact resetting of their Ar-39-Ar-40 (K-Ar) ages approximately equal to 3.4-4.1 Ga ago, and many specimens show some disturbance of other radiometry chronometers as well. Bogard (1995) argued that this age resetting occurred on Vesta and was produced by the same general population of objects that produced many of the lunar impact basins. The exact nature of the lunar late heavy bombardment (LHB or 'cataclysm') remains controversial, but the timing is similar to the reset ages of eucrites. Neither the beginning nor ending time of the lunar LHB is well constrained. Comparison of Ar-Ar ages of brecciated eucrites with data for the lunar LHB can resolve both the origin of these impactors and the time period over which they were delivered to the inner solar system. This abstract reports some new Ar-Ar age data for eucrites, obtained since the authors' 1995 and 2003 papers.

  3. Ar-40/Ar-39 Ages of Maskelynite Grains from ALHA 77005 (United States)

    Turrin, B.; Park, J.; Herzog, G. F.; Lindsay, F. N.; Delaney, J. S.; Nyquist, L. E.; Swisher, C., III


    We present Ar-40/Ar-39 measurements for twelve small (20-60 micro-g) maskelynite samples from the heavily shocked martian meteorite ALHA 77005. The reported modal composition for ALHA 77005 is 50-60% olivine (Fa28), 30-40% pyroxene (Wo5Fs23En72), approx.8% maskelynite (An53), and approx.2% opaques by volume [1]). The meteorite is usually classified as a lherzolite. Previous Studies - Ar-40/Ar-39 results from previous work display disturbed release spectra [2,3]. In study [2], Ar-40/Ar-39 measurements on a 52-mg whole-rock sample produced an extremely disturbed release spec-trum, with all calculated apparent ages > 1 Ga, (Fig. 1). In a subsequent study [3], a light and a dark phase were analyzed. A 2.3-mg sample of the light, relatively low-K phase produced a disturbed release spectrum. For the first 20% of the Ar-39(sub K), most of the apparent ages exceeded >1 Ga; the remaining 80% yielded ages between 0.3-0.5 Ga. The integrated age for this phase is 0.9 Ga.

  4. Solar collectors. Technical progress report No. 1, September 5, 1978-March 5, 1979. [Listing of glazings, housing materials, acrylic coatings, etching processes and AR coatings

    Energy Technology Data Exchange (ETDEWEB)

    Baum, B.; Gage, M.


    A broad information search was carried out in four areas: glazings, housing materials, acrylic coatings, etching processes and AR coatings. An extensive list of all (known) US transparent polymers was developed as well as tables of plastic, ceramic and metallic materials that could conceivably function as a housing. In addition, a compilation was made of commercially available solvent and water-base acrylic coatings for use as a uv protective coating for the glazing. Eighteen transparent polymers were chosen as possible glazings and twelve materials (plastic and wood) as possible housings and exposed in the Weather-Ometer as tensile bars and for the glazings as disks for optical transmission. These same materials were also exposed on our roof to monitor soiling. A variety of solvent and water-base acrylics were selected as protective coatings and ordered. Two commercial films - Tedlar 20 and Halar 500 - with strong absorption in the uv and two commercial films containing uv absorbers - Tedlar UT and Korad 201R - were laminated by several different processes to four promising glazing materials: polyvinyl fluoride (Tedlar), polymethyl methacrylate (Plexiglass), crosslinked ethylene/vinyl acetate and thermoplastic polyester (Llumar). A variety of etching processes were briefly explored and AR coating studies started on the above four glazing films.

  5. The effects of retrograde reactions and of diffusion on 39Ar-40Ar ages of micas

    DEFF Research Database (Denmark)

    Allaz, Julien; Engi, Martin; Berger, Alfons


    Effects of metamorphic reactions occurring during decompression were explored to understand their influence on 39Ar-40Ar ages of micas. Monometamorphic metasediments from the Lepontine Alps (Switzerland) were studied. Collected samples reached lower amphibolite facies during the Barrovian....../K and Cl/K ratios) did not change and the resulting ages can be interpreted unambiguously. In mineral separates containing two white micas, Ca/K and Cl/K ratios were variable, reflecting non-simultaneous laboratory degassing of the two heterochemical Ar-reservoirs. These ratios were used to identify each...... Ar reservoir and to unravel the age. In a chlorite-margarite-biotite-calcschist equilibrated near 560 °C and 0.65 GPa, biotite, margarite, and muscovite all yield ages around 18 Ma. At slightly higher grade (560-580 °C, 0.8-0.9 GPa), the assemblage muscovite-paragonite-plagioclase is at equilibrium...

  6. Astronomical calibration of 40Ar/39Ar reference minerals using high-precision, multi-collector (ARGUSVI) mass spectrometry (United States)

    Phillips, D.; Matchan, E. L.; Honda, M.; Kuiper, K. F.


    The new generation of multi-collector mass spectrometers (e.g. ARGUSVI) permit ultra-high precision (1%) in 40K decay constants and the ages of natural reference minerals that form the basis of the technique. For example, reported ages for widely used 40Ar/39Ar reference materials, such as the ca. 28 Ma Fish Canyon Tuff sanidine (FCTs) and the ca. 1.2 Ma Alder Creek Rhyolite sanidine (ACRs), vary by >1%. Recent attempts to independently calibrate these reference minerals have focused on K-Ar analyses of the same minerals and inter-comparisons with astronomically tuned tephras in sedimentary sequences and U-Pb zircon ages from volcanic rocks. Most of these studies used older generation (effectively single-collector) mass spectrometers that employed peak-jumping analytical methods to acquire 40Ar/39Ar data. In this study, we reassess the inter-calibration and ages of commonly used 40Ar/39Ar reference minerals Fish Canyon Tuff sanidine (FCTs), Alder Creek Rhyolite sanidine (ACRs) and Mount Dromedary biotite (MD2b; equivalent to GA-1550 biotite), relative to the astronomically tuned age of A1 Tephra sanidine (A1Ts), Faneromeni section, Crete (Rivera et al., 2011), using a multi-collector ARGUSVI mass spectrometer. These analyses confirm the exceptional precision capability (0.1% in the 40Ar/39Ar ages of reference minerals without consideration of recoil artefacts, thus limiting the benefits of high precision multi-collector analyses. Significant improvement to the accuracy of the 40Ar/39Ar method (<0.1%) will require further inter-laboratory 40Ar/39Ar studies utilizing multi-collector mass spectrometry, additional constraints on recoil 39ArK loss from reference minerals, further resolution of discrepancies between astronomically tuned sedimentary successions and refinement of the 238U/206Pb zircon age cross-calibration approach.

  7. Ramon Llull's Ars Magna

    DEFF Research Database (Denmark)

    Jensen, Thessa

    ; conceived and written in the late 13th century by a lay-monk whose life alone would be worth a Hollywood movie. In this paper I will take a brief look at Llull’s life and work, before explaining the four main parts of his Ars Magna. Finally, I will try to give a new perspec-tive on how the Ars Magna still...... might be a viable and valuable approach to understand some of the challenges and possibilities found in computer science and ethics. Vita Llull was born in 1232 in Palma de Mallorca, a melting pot for different cul-tures and religions at the time. Being educated at the king’s court, Llull learned...... the trade of the troubadour as well as reading and writing in Catalan. He became a devout Christian later in life only after he had married. Jesus showed himself to Llull on several occasions, and eventually Llull resumed his rather debauched life and decided to dedicate the rest of his life to three...

  8. Spina bifida with higher position of sacral hiatus: a case report with clinical implications. (United States)

    Srijit, D; Shipra, P


    Spina bifida is a developmental defect in the vertebral column, in which the laminae fail to fuse and thereby the spinal cord is relatively unprotected. We report a case of spina bifida, in a dried specimen of sacrum, characterized by a prominent S1 spine and a higher sacral hiatus. Conventional textbooks of anatomy provide less information about the clinical implications of such anomalies and research studies are the only source of information. The present study, discusses in detail, the structural and radiological aspects of spina bifida, with a higher sacral hiatus. Precise knowledge of normal and abnormal anatomy of the sacrum may be clinically important for anesthetists, neurologists, radiologists and orthopedic surgeons, in their clinical practice (Fig. 3, Ref. 16). Full Text (Free, PDF)

  9. Higher education and eesearch report of the hearing held on 8 December, 2015



    This is a report of the hearing that took place on Tuesday 8th December 2015 from 1730 to 2000hrs. This was the second session in the series of the ‘LSE Commission on the Future of Britain in Europe’.\\ud Respected practitioners and experts in higher education and research took up our invitation to participate in the hearing to discuss the risks of a Brexit and how universities might act at this important moment in British life. Participants included those with high level and/or frontline expe...

  10. Discordant K-Ar and young exposure dates for the Windjana sandstone, Kimberley, Gale Crater, Mars (United States)

    Vasconcelos, P. M.; Farley, K. A.; Malespin, C. A.; Mahaffy, P.; Ming, D.; McLennan, S. M.; Hurowitz, J. A.; Rice, Melissa S.


    K-Ar and noble gas surface exposure age measurements were carried out on the Windjana sandstone, Kimberley region, Gale Crater, Mars, by using the Sample Analysis at Mars instrument on the Curiosity rover. The sandstone is unusually rich in sanidine, as determined by CheMin X-ray diffraction, contributing to the high K2O concentration of 3.09 ± 0.20 wt % measured by Alpha-Particle X-ray Spectrometer analysis. A sandstone aliquot heated to 915°C yielded a K-Ar age of 627 ± 50 Ma. Reheating this aliquot yielded no additional Ar. A second aliquot heated in the same way yielded a much higher K-Ar age of 1710 ± 110 Ma. These data suggest incomplete Ar extraction from a rock with a K-Ar age older than 1710 Ma. Incomplete extraction at 900°C is not surprising for a rock with a large fraction of K carried by Ar-retentive K-feldspar. Likely, variability in the exact temperature achieved by the sample from run to run, uncertainties in sample mass estimation, and possible mineral fractionation during transport and storage prior to analysis may contribute to these discrepant data. Cosmic ray exposure ages from 3He and 21Ne in the two aliquots are minimum values given the possibility of incomplete extraction. However, the general similarity between the 3He (57 ± 49 and 18 ± 32 Ma, mean 30 Ma) and 21Ne (2 ± 32 and 83 ± 24 Ma, mean 54 Ma) exposure ages provides no evidence for underextraction. The implied erosion rate at the Kimberley location is similar to that reported at the nearby Yellowknife Bay outcrop.

  11. Ar-Ar and Rb-Sr Ages of the Tissint Olivine-phyric Martian Shergottite (United States)

    Park, J.; Herzog, G. F.; Nyquist, L. E.; Shih, C.-Y.; Turin, B.; Lindsay, F. N.; Delaney, J. S.; Swisher, C. C., III; Agee, C.


    The fifth martian meteorite fall, Tissint, is an olivine-phyric shergottite that contains olivine macrocrysts (approximately 1.5 mm) [1]. [2] reported the Sm-Nd age of Tissint as 596 plus or minus 23 Ma along with Rb-Sr data that defined no isochron. [3] reported Lu-Hf and Sm-Nd ages of 583 plus or minus 86 Ma and 616 plus or minus 67 Ma, respectively. The cosmic-ray exposure ages of Tissint are 1.10 plus or minus 0.15 Ma based on 10Be [4], and 1.0-1.1 Ma, based on 3He, 21Ne, and 38Ar [5,6].We report Ar-Ar ages and Rb-Sr data.

  12. 40Ar/39Ar age calibration against counted annuallayers

    DEFF Research Database (Denmark)

    Storey, Michael; Stecher, Ole


    worth exploring for an improved absolute age basis for the 40Ar/39Ar system is through cross-calibration with counted annual layers (e.g. tree rings, varves and ice cores). North Atlantic Ash Zone (NAAZ) II is found within the dated part of the annual Greenland ice core record. NAAZ II has been...

  13. Multiple target ionization in collisions between highly charged ions and Ar

    NARCIS (Netherlands)

    deNijs, G; Hoekstra, R; Morgenstern, R


    We have performed measurements on charge-state distributions of target ions produced in collisions of C6+, N6+, O6+, Ne6+, Ar6+ and Kr6+ on Ar. Charge states of Ar target ions higher than the initial projectile charge state are observed for C6+, N6+ and O6+. This intriguing observation seems to

  14. War and Peace among the Words: Rhetoric, Style and Propaganda in Response to National Reports on Higher Education. (United States)

    Adelman, Clifford

    Responses to national reports during October 1984 through May 1985 concerning the state of American higher education are analyzed. Quantitative content analysis and qualitative rehetorical criticism are used to examine responses to national reports. Three national reports are of concern: "Involvement in Learning,""A Nation at…

  15. Compendium on Financing of Higher Education: Final Report of the Financing the Students' Future Project (United States)

    Payne, Bethan; Charonis, George-Konstantinos; Haaristo, Hanna-Stella; Maurer, Moritz; Kaiser, Florian; Siegrist, Rahel; McVitty, Debbie; Gruber, Angelika; Heerens, Nik; Xhomaqi, Brikena; Nötzl, Tina; Semjonov, Meeli; Primožic, Rok


    Higher education plays a vital role in society and the quality, accessibility, and form of higher education is highly dependent on financing. Financing of higher education is conceived to be of central importance for the future creation and dissemination of knowledge and research. Therefore, the financing of higher education is a topic that has…

  16. Natural gas conversion to higher hydrocarbons using plasma interactions with surfaces. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Sackinger, W.M.; Kamath, V.A.; Morgan, B.L.; Airey, R.W.


    Experiments are reported in which a methane plasma is created, and the methyl ions and hydrogen ions are accelerated within a microchannel array so that they interact with neutral methane molecules on the inside surfaces of the microchannels. No catalysts are used, and the device operates at room temperature. Impact energies of the ions are in the range of 10 eV to greater than 100 eV, and the energy delivered in the interaction at the surfaces causes the production of larger hydrocarbon molecules, such as C{sub 2}H{sub 2}, C{sub 2}H{sub 4}, and C{sub 2}H{sub 6}, along with C{sub 3}, C{sub 4}, C{sub 5}m C{sub 6}, C{sub 7}m and C{sub 8} molecules. There is a decreasing percentage of larger molecules produced, in comparison with the C{sub 2} and C{sub 3} types. Conversion effectiveness is greater at higher pressure, due to the increased ionic activity. The yield of the higher hydrocarbons depends upon the external voltage used, and voltage can be used as a control parameter to adjust the output mixture proportions. A conversion energy of 2.59 kilowatt hours/killogram of output has been demonstrated, and a reduction of this by a factor of 10 is possible using known techniques. In batch experiments, the selectivity for C{sub 2} has varied from 47% to 88%, and selectivity for C{sub 6} has ranged from 0% to 12.8%. Other hydrocarbon selectivities also span a wide and useful range. The estimated costs for hydrocarbons produced with this technology are in the range of $200 per tonne, in production quantities, depending upon natural gas costs. Pilot production experiments are recommended to make these estimates more precise, and to address strategies for scaling the technology up to production levels. Applications are discussed.

  17. A Review of Two Higher Education Accountability Issues: Student Assessment and Faculty Workload. Report to Utah State Legislature. Report Number 91-03. (United States)

    Utah State Office of the Legislative Auditor General, Salt Lake City.

    This report, in examining higher education accountability, reviews how student assessment is used nationally and in Utah to improve higher education accountability, and reviews the methods used in Utah to monitor faculty workload. Student assessments do provide a direct method of evaluating higher education effectiveness, and Utah's institutions…

  18. Institutional wide implementation of key advice for socially inclusive teaching in higher education. A Practice Report

    Directory of Open Access Journals (Sweden)

    Lisa Thomas


    Full Text Available Government policy and institutional initiatives have influenced increases in enrolment of non-traditional students to Australian universities. For these students, university culture is often incongruent with their own, making it difficult to understand the tacit requirements for participation and success. Academic teaching staff are important in creating socially inclusive learning experiences, particularly in first year subjects. This paper presents an institution-wide approach to enhancing socially inclusive teaching at one Australian university. Underpinned by a framework of ”bridging social-incongruity” the initiative was guided by six principles of socially inclusive teaching to support practice as proposed in the 2012 “Effective support of students from low socioeconomic backgrounds in higher education” report commissioned by the Australian Office of Learning and Teaching. Feedback from 150 academic teaching staff from various disciplines and campus locations, suggests this initiative was effective in increasing understanding of socially inclusive teaching practices with many participants indicating the teaching enhancements were applicable for their teaching context.

  19. Survey report of NOAA Ship McArthur II cruises AR-04-04, AR-05-05 and AR-06-03: habitat classification of side scan sonar imagery in support of deep-sea coral/sponge explorations at the Olympic Coast National Marine Sanctuary (United States)

    Intelmann, Steven S.; Cochrane, Guy R.; Bowlby, C. Edward; Brancato, Mary Sue; Hyland, Jeffrey


    Habitat mapping and characterization has been defined as a high-priority management issue for the Olympic Coast National Marine Sanctuary (OCNMS), especially for poorly known deep-sea habitats that may be sensitive to anthropogenic disturbance. As a result, a team of scientists from OCNMS, National Centers for Coastal Ocean Science (NCCOS), and other partnering institutions initiated a series of surveys to assess the distribution of deep-sea coral/sponge assemblages within the sanctuary and to look for evidence of potential anthropogenic impacts in these critical habitats. Initial results indicated that remotely delineating areas of hard bottom substrate through acoustic sensing could be a useful tool to increase the efficiency and success of subsequent ROV-based surveys of the associated deep-sea fauna. Accordingly, side scan sonar surveys were conducted in May 2004, June 2005, and April 2006 aboard the NOAA Ship McArthur II to: (1) obtain additional imagery of the seafloor for broader habitat-mapping coverage of sanctuary waters, and (2) help delineate suitable deep-sea coral-sponge habitat, in areas of both high and low commercial-fishing activities, to serve as sites for surveying-in more detail using an ROV on subsequent cruises, Several regions of the sea floor throughout the OCNMS were surveyed and mosaicked at 1-meter pixel resolution. Imagery from the side scan sonar mapping efforts was integrated with other complementary data from a towed camera sled, ROVs, sedentary samples, and bathymetry records to describe geological and biological (where possible) aspects of habitat. Using a hierarchical deep-water marine benthic classification scheme (Greene et al. 1999), we created a preliminary map of various habitat polygon features for use in a geographical information system (GIS). This report provides a description of the mapping and groundtruthing efforts as well as results of the image classification procedure for each of the areas surveyed.

  20. Evaluation of the IPCC Models (AR4 and AR5) in the Precipitation Simulation in the Northeast of Brazil (United States)

    Alves, José; Vasconcelos Junior, Francisco; Chaves, Rosane; Silva, Emerson; Servain, Jacques; Costa, Alexandre; Sombra, Sérgio; Barbosa, Augusto; Dos Santos, Antonio


    With the simulations of the models used in the latest reports from the Intergovernmental Panel on Climate Change (IPCC), comparative studies are necessary between observations and the so-called historical run (C20) and future projections of the AR4 (A2) and AR5 (RCP8.5) experiments, in order to assess whether the AR5 models had a better performance in the representation of physical processes. This article compares the sensitivity of IPCC models (AR4 and AR5) in representing the anuall average and seasonal rainfall variation (summer and autumn) in three regions of the Northeast of Brazil between 1979 and 2000, using the CMAP - CPC (Merged Analysis of Precipitation) data as reference. The projections made by these models for the period 2040-2070 were also analyzed.

  1. Neutron-hole states in 45Ar from p(46Ar,d)45Ar reactions

    CERN Document Server

    Lu, F; Tsang, M B; Bazin, D; Coupland, D; Henzl, V; Henzlova, D; Kilburn, M; Lynch, W G; Rogers, A M; Sanetullaev, A; Sun, Z Y; Youngs, M; Charity, R J; Sobotka, L G; Famiano, M; Hudan, S; Horoi, M; Ye, Y L


    To improve the effective interactions in the pf shell, it is important to measure the single particle- and hole- states near the N=28 shell gap. In this paper, the neutron spectroscopic factors of hole-states from the unstable neutron-rich 45Ar (Z=18, N=27) nucleus have been studied using 1H(46Ar, 2H)45Ar transfer reaction in inverse kinematics. Comparison of our results with the particle-states of 45Ar produced in 2H(44Ar, H)45Ar reaction shows that the two reactions populate states with different angular momentum. Using the angular distributions, we are able to confirm the spin assignments of four low-lying states of 45Ar. These are the ground state (f7/2), the first-excited (p3/2), the s1/2 and the d3/2 states. While large basis shell model predictions describe spectroscopic properties of the ground and p3/2 states very well, they fail to describe the s1/2 and d3/2 hole-states.

  2. Ars Poetica : [luuletused] / Mats Traat

    Index Scriptorium Estoniae

    Traat, Mats, 1936-


    Sisu: Ars poetica ; Veepeegel ; Kontrollõed ; Mandariiniriik ; Nikolai Siamashvili (1888-1911) ; Kolmekümne kolmas aasta ; Kiri linast 1966 ; Italmaz Nuriyev ; Rudolf Rimmelile mõeldes ; Gennadi Aigi

  3. Ars Poetica : [luuletused] / Mats Traat

    Index Scriptorium Estoniae

    Traat, Mats, 1936-


    Sisu: Ars poetica ; Veepeegel ; Kontrollõed ; Mandariiniriik ; Nikolai Siamashvili (1888-1911) ; Kolmekümne kolmas aasta ; Kiri linast 1966 ; Italmaz Nuriyev ; Rudolf Rimmelile mõeldes ; Gennadi Aigi

  4. Pulsed discharge production Ar* metastables (United States)

    Han, Jiande; Heaven, Michael C.; Emmons, Daniel; Perram, Glen P.; Weeks, David E.; Bailey, William F.


    The production of relatively high densities of Ar* metastables (>1012 cm-3) in Ar/He mixtures, at total pressures close to 1 atm, is essential for the efficient operation of an optically pumped Ar* laser. We have used emission spectroscopy and diode laser absorption spectroscopy measurements to observe the production and decay of Ar* in a parallel plate pulsed discharge. With discharge pulses of 1 μs duration we find that metastable production is dominated by processes occurring within the first 100 ns of the gas break-down. Application of multiple, closely spaced discharge pulses yields insights concerning conditions that favor metastable production. This information has been combined with time-resolved measurements of voltage and current. The experimental results and preliminary modeling of the discharge kinetics are presented.

  5. 40Ar/39Ar ages of the older eruptive units of Somma-Vesuvius volcano, Italy (United States)

    Lanphere, M. A.; Calvert, A. T.; Scarpati, C.; Melluso, L.; Morra, V.; Perrotta, A.; Thornber, C.; Cioni, R.; Champion, D. E.


    40Ar/ 39Ar ages have been measured on the older major explosive eruptions of Somma-Vesuvius volcano in Italy. These eruptions all have pumice fall, and pyroclastic surge and flow deposits. The eruptive history of Somma-Vesuvius volcano has previously been based on uncalibrated 14C ages, mostly on carbon from paleosols, reported by Delibrias and others (1979) and Sigurdsson and others (1985). These assigned ages, plus measured 14C ages, calibrated 14C ages (denoted as 14C*) and 40Ar/ 39Ar ages (all in years) are: Mercato Tuff ~8500 years 14C=8263±29, 14C*=9250±49, 40Ar/ 39Ar=9155±461, 9541±460 Verde Tuff ~15000 years 14C=14420±130, 14C*=17200±380, 40Ar/ 39Ar=18456±302 Pomici di Base ~17000 years 14C=17229±398, 14C*=20360±139, 40Ar/ 39Ar=21759±306, 21568±328 The assigned ages are from Delibrias (1979). The 14C ages (Aleisso and others, 1971, 1973, 1974, 1978) use 1σ counting errors reported by laboratories. The uncertainty in calibrated 14C ages (above) are these reported uncertainties plus 1σ uncertainties of the calibration curves in IntCal04 (Reimer and others, 2004). The uncertainties in 40Ar/ 39Ar ages are 1σ errors. Pomici di Base and Mercato samples were analyzed twice. The weighted mean of plateau ages for Pomici di Base fall unit is 21,670 ± 224 years, and the weighted mean of isochron ages is 21,313 ± 408 years. The weighted mean of plateau ages for Mercato Tuff is 9348 ± 326 years, and the weighted mean of isochron ages is 9577 ± 332 years. The period of time from 0-12.4 ka used in calibrating 14C ages is based on dendrochronologically-dated tree ring samples. The calibration older than 12.4 ka is based on marine samples, primarily corals, and the marine calibrations are in dispute. The calibrated 14C ages above are based on IntCal04. Chui and others (2007) have presented another calibration based on fossil corals. In the younger part of their record, less than 30,000 years, the age difference averages less than 100 years. Aleisso and

  6. Direct measurement of additional Ar-H2O vibration-rotation-tunneling bands in the millimeter-submillimeter range (United States)

    Zou, Luyao; Widicus Weaver, Susanna L.


    Three new weak bands of the Ar-H2O vibration-rotation-tunneling spectrum have been measured in the millimeter wavelength range. These bands were predicted from combination differences based on previously measured bands in the submillimeter region. Two previously reported submillimeter bands were also remeasured with higher frequency resolution. These new measurements allow us to obtain accurate information on the Coriolis interaction between the 101 and 110 states. Here we report these results and the associated improved molecular constants.

  7. The Economics of Higher Education: A Report Prepared by the Department of the Treasury with the Department of Education (United States)

    US Department of the Treasury, 2012


    This report discusses the current state of higher education, with a brief high-level overview of the market and a more detailed discussion and analysis of the financial aid system. It also discusses the important changes President Obama has made to make higher education more accessible and affordable. The key findings are: (1) The economic returns…

  8. The Hunt Report and Higher Education Policy in the Republic of Ireland: "An International Solution to an Irish Problem?" (United States)

    Walsh, John; Loxley, Andrew


    The "National Strategy for Higher Education to 2030" in the Republic of Ireland (universally known as the Hunt Report) represents the latest and most assertive attempt by the Irish state to re-construct higher education in accordance with economic utilitarian objectives. This paper sets out to analyse the historical context, key themes…

  9. Building on Success: Educational Diversity and Equity in Kentucky Higher Education. Choices before the Commonwealth. Final Report (United States)

    Ancheta, Angelo; Ledesma, Maria; Trent, William; Kurlaender, Michal; Yun, John; Lee, Chungmei; Siegel-Hawley, Genevieve; Driscoll, Anne; Orfield, Gary


    This report is an effort to assess what has been accomplished in successfully diversifying and desegregating historically segregated and unequal higher educational institutions across Kentucky, and how this was done. The report discusses the changing legal setting for these initiatives, analyzes the educational achievements and challenges, and…

  10. Laboratory Report (LR) to the paper Foundation of an analytical proton beamlet model for inclusion in a general proton dose calculation system [arXiv:1009.0832

    CERN Document Server

    Ulmer, W


    We have developed a model for proton depth dose and lateral distributions based on Monte Carlo calculations (GEANT4) and an integration procedure of the Bethe-Bloch equation (BBE). The model accounts for the transport of primary and secondary protons, the creation of recoil protons and heavy recoil nuclei as well as lateral scattering of these contributions. The buildup, which is experimentally observed in higher energy depth dose curves, is modeled by inclusion of two different origins: 1. Secondary reaction protons with a contribution of ca. 65 % of the buildup (for monoenergetic protons). 2. Landau tails as well as Gaussian type of fluctuations for range straggling effects. All parameters of the model for initially monoenergetic proton beams have been obtained from Monte Carlo calculations or checked by them. Furthermore, there are a few parameters, which can be obtained by fitting the model to measured depth dose curves in order to describe individual characteristics of the beamline - the most important b...

  11. Teaching Strategies Adopted by Teachers at Higher Education Level in Kerala: A Research Report (United States)

    Jesa, M.; Nisha, E. V.


    In the special context of entrepreneurship, employability skill development, Higher Education 2.0 and the Kovalam Declaration 2016, the present article presents a brief review of genres of teaching strategies at higher education level and attempts to bring to the attention of the readers an account of the teaching strategies adopted by teachers at…

  12. Expression of ER and AR in lung cancer

    Directory of Open Access Journals (Sweden)

    Shuling WANG


    Full Text Available Background and objective Epidemiology of lung cancer differs between sexes and it might be partially explained by different sex hormone levels in women and men. There are some epidemiological data indicating that gender is a significant, independent prognostic factor in lung cancer. The aim of this study is to determine expression of ER (estrogen receptor and AR (androgen receptor in lung cancer, and evaluate the relationship between their expression and clinical or pathologic characteristics. Methods Immunohistochemistry assay was used to detect expression of ER and AR. Results Positive expression of ER and AR were 14.3%(15/105 and 20%(21/105. Positive expression of ER had no relationship with age, gender, pathology, histological differentiation, TNM staging, size of tumor and lymph node metastasis. Although age, gender, pathology, histological differentiation and size of tumor had no effect on the expression of AR, positive rate of AR in staging III lung cancer was significantly higher than that in staging I lung cancer. The different AR expression was significant between N0 and N2 lymph node metastasis ( Chisquare= 4.7828,P=0.0287. Conclusion The expression of ER has no relationship with biological behavior. Positive expression of AR may be correlated with the progression and the lymph node metastasis of lung cancer.

  13. Reflections on the Future of Global Higher Education - WAAS Conference Report

    Directory of Open Access Journals (Sweden)

    Ivo Šlaus


    Full Text Available Education is the most important catalyst of social evolution. Today higher education is in the early stages of a revolutionary transition that will have immense impact on the future of global society. This article presents an overview of perspectives explored at the World Academy's Forum on Global Higher Education conducted at the University of California at Berkeley on October 2-3, 2013. It examines issues resulting from rapid changes in educational technology and organization that impact on accessibility, affordability, quality, relevance, employability and content of higher education. It envisions establishment of a World University Consortium as a network and umbrella group to facilitate educational partnerships and linkages with other interested stakeholders at the international level, to provide a centralized source of information about latest innovative ideas and developments in this field, and to explore creative solutions to enhance the reach, quality and relevance of higher education globally.

  14. Ba{anti B}ar status report on the design of a detector for the study of CP violation at PEP-II at SLAC

    Energy Technology Data Exchange (ETDEWEB)


    Experiments designed to measure CP-violating asymmetries in the B meson system must emphasize exclusive state reconstruction with the highest possible resolution and efficiency. In the case of B{sup 0} mesons produced in pairs at the {Upsilon}(4S) resonance at an asymmetric e{sup +}e{sup {minus}} storage ring, this capability must be accompanied by precise vertex reconstruction in the direction of the e{sup +}e{sup {minus}} beams (henceforth the z direction). These are difficult requirements, beyond the scope of any existing storage ring detector. The challenge of designing an asymmetric storage ring capable of producing the large number of neutral B meson pairs required to measure CP-violating asymmetries in decays to CP eigenstates has been handsomely met in the PEP-II design. As the first asymmetric e{sup +}e{sup {minus}} storage ring, PEP-II presents a novel set of experimental challenges to a 4{pi} detector. This Status Report describes the design of a new detector fully capable of exploiting the physics opportunities provided by PEP-II.

  15. Ar40/Ar39计时及西藏南部喜马拉雅期几个黑云母年龄的测定

    Institute of Scientific and Technical Information of China (English)

    戴橙谟; 洪阿实


    Five biotites of Himalayan Period from southern Xizang platean have been irradiated and determined using reactor No. 901 in Qinghua University as fast neutron source(neutron flux 1.17× 1013n/cm2·s, fast neutron - 25%, duration of irradiation 18 hours) and MMhb-1 hornblende from USA as standard. Most of the samples were also determined by Ar36 isotope dilation method, and good agreement has been obtained for the results between the two approaches. This shows that Ar40/Ar39 dating is capable to distinguish clearly the order of intrusion among the multiphase intrnsions with respect to the young granites of Himalayan Period. Powder sample of CaF2 and K2SO4 were irradiated and ratios of (Ar36/Ar37)Ca. and(Ar39/Ar37)Ca and (Ar40/Ar39)x have been measured, which are of the same magnitutc of order as reported from other reac-tors in the world. For the ZBH-2506 biotite standard of China, Ar40/Ar39 age (130.9--131.9my)agrees with the age of 131±2.6 my as determined by dilution method. Plateau age obtained by step-wise heating (131±0.8my) is similar with the data obtained from total fusion and dilution methods.

  16. Unveiling Turrialba (Costa Rica) volcano's latest geological evolution through new 40Ar/39Ar, ages (United States)

    Ruiz Cubillo, P.; Turrin, B. D.; Soto, G. J.; Del Potro, R.; Gagnevin, D.; Gazel, E.; Mora Fernandez, M.; Carr, M. J.; Swisher, C. C.


    Step-heating 40Ar/39Ar dating experiments on whole rock matrix were performed on samples from eight key lava flow units from Turrialba, the easternmost volcano of the Central Volcanic Range of Costa Rica. Our results, together with available corrected 14C ages, recent mapping and new geochemical analyses, are part of a study to reconstruct Turrialba’s evolution. The project is being conducted as part of wider studies because of the increase in volcanic activity during the last three years. The geochemical compositions of the lava flow units span the range from basalts to dacites, and commonly have high K2O concentrations, making them good candidates for 40Ar/39Ar radiometric dating. The ages reported here correspond to the Paleo Turrialba (600-250 ka) and Neo Turrialba (< 250 ka) temporal stages. Sample TUR-38 (251 ± 4 ka) belongs to the latest unit of Paleo Turrialba stage, known as Finca Liebres volcano, while the remaining seven samples belong to Neo Turrialba: TUR-30 (99 ± 3 ka), TUR-19 (90 ± 4 ka), TUR-32 (62 ± 2 ka) TUR-33 (61 ± 2 ka), TUR-12 (25 ± 1.9 ka), TUR-36 (10 ± 3 ka) and TUR-08 (3 ± 3 ka). All the obtained ages in this study are in agreement with the local stratigraphy and prior 14C age determinations, adding robustness to our results. According to ages obtained and the areal distribution of the sampled units, the most important construction period of the massif was during the Neo-Turrialba stage which has passed through two important constructing episodes, around 100-60 ka and 10 ka-present. Although our results include some very young ages, all of them meet the established evaluation criteria used for plateau and isochron ages, commonly used for 40Ar/39Ar dating. Furthermore, we used a protocol that closely monitors the mass spectrometer mass discrimination during the measurements to provide additional control. Three of the eight 40Ar/39Ar ages reported here are remarkably young (25 ka or less). Two of those are the samples with the

  17. Analysis list: Ar [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Ar Gonad,Kidney,Prostate + mm9,,,http://dbarchive.bioscience

  18. Analysis list: AR [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available AR Blood,Breast,Prostate + hg19 http:...//,,,http:

  19. 40Ar-39Ar age of a lava flow from the Bhimashankar Formation, Giravali Ghat, Deccan Traps

    Indian Academy of Sciences (India)

    Kanchan Pande; S K Pattanayak; K V Subbarao; P Navaneethakrishnan; T R Venkatesan


    We report here a 40Ar-39Ar age of 66.0 ± 0.9Ma (2 ) for a reversely magnetised tholeiitic lava flow from the Bhimashankar Formation (Fm.), Giravali Ghat, western Deccan province, India. This age is consistent with the view that the 1.8–2km thick bottom part of the exposed basalt flow sequence in the Western Ghats was extruded very close to 67.4 Ma.

  20. KRONOS: A Monte Carlo event generator for higher order QED corrections at HERA — Status report (United States)

    Anlauf, Harald; Manakos, Panagiotis; Mannel, Thomas; Dahmen, Hans D.; Ohl, Thorsten


    We report on the status of the Monte Carlo event generator KRONOS for deep inelastic lepton hadron scattering at HERA. KRONOS focusses on the description of electronmagnetic corrections beyond the existing fixed order calculations.

  1. Higher Education for the 1980s. Challenges and Responses. Report of the Hiroshima International Seminar on Higher Education (2nd, Hiroshima, Japan, January 29-31, 1980). (United States)

    Hiroshima Univ. (Japan). Research Inst. for Higher Education.

    The challenges of social change, values crises, societal needs for higher education, the internal dynamics of higher educational systems, and future reforms in higher education were discussed at the Second Hiroshima International Seminar on Higher Education. Topics discussed include: Higher Education in an Age of Internationalization (Michio…

  2. 40Ar/39Ar dating of Daqingshan thrust

    Institute of Scientific and Technical Information of China (English)

    LIU Zhenghong; XU Zhongyuan; YANG Zhensheng


    The Daqingshan thrust system, to the south of the Shiguai Mesozoic basin, is a complex system of top-to- the-north thrusting tectonic sheets. The thrust system has a complicated evolution due to multi-stage thrusting. In order to date the thrusting events, syntectonic muscovite and biotite grains are respectively analyzed with normal 40Ar/39Ar dating and laser 40Ar/39Ar dating, which yield 2 isochron ages, i.e. 193.74 ± 3.88 Ma and 121.6 ± 1.6 Ma. These ages suggest that faults within the Daqingshan thrust system formed during 2 stages of thrusting, one the early Indosinian and the other the late Yanshanian. The isotopic dating is consistent with field geological relations. Indosinan deformation is evidenced by top-to-the-north thrusting, with the occurrence of a series of large-scale east-west trending thrust faults and folds, while the Yanshanian thrusting is characterized by top-to-the-NNW thrusting. It is superposed on and modifies early Indosinian thrust faults.

  3. New high-precision 40Ar/39Ar ages on Oligocene volcanic rocks of northwestern Kenya (United States)

    Brown, Francis H.; Jicha, Brian R.


    New, high-precision 40Ar/39Ar ages from volcanic rocks in northwestern Kenya are provided for some areas of exposure in this remote area. We report seven 40Ar/39Ar ages generated from single crystal total fusion experiments on alkali feldspar separated from volcanic rocks in the Mogila, Songot, and Lokwanamur Ranges and the Gatome valley. A rhyolite from the lower part of the sequence in the Mogila Range yielded ages of 32.31 ± 0.06 Ma and 32.33 ± 0.07 Ma, and a rhyolite near the top of that sequence yielded 31.67 ± 0.04 Ma. A single sample from the Songot Range yielded an age of 32.49 ± 0.07 Ma, slightly older than the rocks collected from Mogila. In both ranges the early Oligocene rhyolites are underlain by basalts, as is also the case in the Labur Range. Ages of 25.95 ± 0.03 Ma, 25.91 ± 0.04 Ma, and 27.15 ± 0.03 Ma were measured on alkali feldspar from rhyolites from the Lokwanamur Range, and the nearby Gatome valley. All of these rocks are part of an episode of widespread volcanism in northwestern Kenya in the mid-to late Oligocene that is not currently known from the Ethiopian Rift Valley.

  4. 2015 Global Information Technology Report: Consequences on Knowledge Management in Higher Education Institutions in Nigeria (United States)

    Ololube, Nwachukwu Prince; Agbor, Comfort Nkogho; Major, Nanighe Baldwin; Agabi, Chinyere O.; Wali, Worlu I.


    This research is a continuation of a theoretical review that evaluated ICT Policy Outcomes for National Development in relation to Networked Readiness Index (NRI) and the impact it has on knowledge integration and management in higher education institutions in Nigeria. A new dawn in information technology (IT) has initiated new trends in…

  5. Special Report #6. Developing Trends in Content of Collective Bargaining Contracts in Higher Education. (United States)

    Andes, John

    The growth in the number of higher education collective bargaining contracts continues at a rapid pace, although it is taking longer for the initial contract to be negotiated. The data on 131 contracts covering 215 institutions is included in the statistical tables in this document. Collective bargaining has increased in the West and at least one…

  6. Report of the Governor's Commission on Higher Education and the Economy, January 1982. (United States)

    Governor's Blue Ribbon Commission on Higher Education and the Economy of Connecticut, Inc., Hartford.

    The Governor's Commission on Higher Education and the Economy's assessment of the Connecticut system and ways that the educational needs of the economy and the state can be met during a period of declining enrollments and fiscal constraints is presented. Working committees of the commission studied governance and management; business, labor, and…

  7. Brief Report: Joint Attention and Information Processing in Children with Higher Functioning Autism Spectrum Disorders (United States)

    Mundy, Peter; Kim, Kwanguk; McIntyre, Nancy; Lerro, Lindsay; Jarrold, William


    Theory suggests that information processing during joint attention may be atypical in children with Autism Spectrum Disorder (ASD). This hypothesis was tested in a study of school-aged children with higher functioning ASD and groups of children with symptoms of ADHD or typical development. The results indicated that the control groups displayed…

  8. Higher Education Cost Containment. Performance Audit, November 1995. Report of the State Auditor. (United States)

    Colorado State Office of State Auditor, Denver.

    Between June and September 1995, this performance audit examined Colorado higher education cost containment in debt refinancing and improvements to student loan processes according to generally accepted government auditing standards. With respect to debt refinancing, the audit concluded that in general, governing boards and institutions were…

  9. Prepared in Mind and Resources? A Report on Public Higher Education in South Carolina (United States)

    Alacbay, Armand; Poliakoff, Michael


    In 2011, South Carolina Governor Nikki Haley signed into law the South Carolina Higher Education Efficiency and Administrative Policies Act, maintaining the transparency and accountability that lead to increased academic quality and affordability at colleges and universities. It is in this context that ACTA (American Council of Trustees and…

  10. Made in Maine: A State Report Card on Public Higher Education (United States)

    Markley, Eric; Poliakoff, Michael


    Maine is blessed with universities that have records of significant achievement. The seven campuses of the University of Maine System (UMS) together educated over 23,000 students (full-time equivalent) during the past year. But for good reason, in recent years public confidence in higher education throughout the nation has fallen. Half of the…

  11. Reporting the Use of Multiple Imputation for Missing Data in Higher Education Research (United States)

    Manly, Catherine A.; Wells, Ryan S.


    Higher education researchers using survey data often face decisions about handling missing data. Multiple imputation (MI) is considered by many statisticians to be the most appropriate technique for addressing missing data in many circumstances. In particular, it has been shown to be preferable to listwise deletion, which has historically been a…

  12. Toward a Definition of Verbal Reasoning in Higher Education. Research Report. ETS RR-09-33 (United States)

    Burton, Nancy W.; Welsh, Cynthia; Kostin, Irene; VanEssen, Thomas


    This paper briefly summarizes the literatures of reading and reasoning in the last quarter century, focusing mainly on the disciplines of cognitive science, cognitive developmental psychology, linguistics, and educational psychology. These literatures were synthesized to create a framework for defining verbal reasoning in higher education. Eight…

  13. Interdisciplinarity: The Mutable Paradigm. AAHE/ERIC/Higher Education Research Report No 9, 1978. (United States)

    Mayville, William V.

    The many forms of interdisciplinarity in higher education institutions and the various ways it has been used to advance curricular changes are examined. Definitions of interdisciplinarity and its variants (multi-, pluri-, and transdisciplinarity) provide a conceptual framework for the examination. In this study, interdisciplinarity is understood…

  14. Academic Judgment and Grievance Arbitration in Higher Education. Special Report No. 20. (United States)

    Levy, Harold

    The first known analysis of a substantial number of arbitration awards in higher education is presented in an effort to determine whether arbitrators have confined their awards within the contract limitations. All of the arbitration awards generated by the four-year colleges of the State University of New York as well as the awards of the…

  15. European Union Students Studying in English Higher Education Institutions. DIUS Research Report 08-09 (United States)

    Morris, Marian; Rutt, Simon


    This study aimed to identify the pathways, intentions and relevant perceptions of (non-UK) European Union (EU) students entering English higher education. It sought to identify why students wished to obtain an English HE qualification, their attitudes towards the uptake and repayment of tuition fee loans and their future career plans. Drawing on…

  16. Cataloguing E-Books in UK Higher Education Libraries: Report of a Survey (United States)

    Belanger, Jacqueline


    Purpose: The purpose of this paper is to discuss the results of a 2006 survey of UK Higher Education OPACs in order to provide a snapshot of cataloguing practices for e-books. Design/methodology/approach: The OPACs of 30 UK HE libraries were examined in July/August 2006 to determine which e-books were catalogued, and the level of cataloguing…

  17. 2014-2015 State of CRM Use in Higher Education Report (United States)

    American Association of Collegiate Registrars and Admissions Officers (AACRAO), 2010


    The American Association of Collegiate Registrars and Admissions Officers (AACRAO) periodically undertakes research projects to keep themselves and the higher education community in general, informed about relevant current and emerging practices. The aim of this survey was to measure the extent of ownership of Constituent (or Customer)…

  18. Quality: Transforming Postsecondary Education. ASHE-ERIC Higher Education Report No. 3, 1992. (United States)

    Chaffee, Ellen Earle; Sherr, Lawrence A.

    Many colleges and universities, in responding to public demand for higher education and the external challenges it creates, are employing Total Quality Management (TQM) techniques to improve quality, increase productivity, and decrease costs. The quality improvement process itself (the tools for problem identification and developing solutions),…

  19. 40Ar/39Ar dating of Pleistocene tuffs: an accurate age for the Matuyama-Brunhes geomagnetic reversal (MBGR) (United States)

    Mark, D. F.; Renne, P. R.; Morgan, L. E.; Deino, A.; Smith, V. C.; Ellis, B. S.; Pearce, N. J.


    Recent recalibrations of the 40Ar/39Ar system [1,2] reveal inconsistencies with some previous ages inferred for the MBGR. An Ar/Ar age [3] for the Bishop Tuff (BT) (which post-dates the MBGR by at least 15.3 ± 2.2 ka [3]) recalculated [2] yields an age of 778.0 ± 3.8 ka (1σ, full systematic uncertainty). The age is c. 10 ka older than the BT zircon ID-TIMS U-Pb age [4] and places the MBGR at c. 793 ka, c. 13 and 20 ka older than astronomical ages for the MBGR of 780 ka [5] and 773 ka [6], respectively. To determine an accurate age for the MBGR, we have made a series of 40Ar/39Ar age determinations for Pleistocene tuffs from both Indonesia and North America that have direct relationships to the MBGR. Blind analyses were conducted at SUERC and BGC. We observed excellent inter-laboratory agreement and no systematic offset in data. Ar/Ar ages are reported relative to [2] (1σ, full systematic uncertainty). Drill cores from ODP Site 758 show the precise location of the MBGR. Below the MBGR are two distal tephra horizons that we have identified as products of two temporally distinct Old Toba Tuff (OTT) eruptions (layer d OTT1 and layer D OTT2). Continuous sedimentation between OTT1 (802.8 ± 0.7 ka, n = 100, MSWD 1.2) and OTT2 (796.2 ± 0.8 ka, n = 62, MSWD 1.3) allows for calculation of an accurate sedimentation rate and for extrapolation of an age from OTT2 to the MBGR. Data define an age for the MBGR of 795.2 ± 0.9 ka. Using tephra above the MBGR boundary, the Middle Toba Tuff (layer C) and Young Toba Tuff (layer A), extrapolation down core supports a MBGR age of c. 795 ka. Recent age data for BT sanidine reported relative to FCs at 28.172 Ma (767.4 ± 1.1 Ma) [7] oddly yielded an Ar/Ar age that was indistinguishable from the BT zircon U-Pb age [4], which is consistent with previous 40Ar/39Ar age measurements made relative to FCs at 28.02 Ma [3]. Thus we made a series of 40Ar/39Ar measurements on the exact same sample as used by Rivera et al. [7] and observed

  20. Chromosomal context and replication properties of ARS plasmids in Schizosaccharomyces pombe

    Indian Academy of Sciences (India)

    Aditya S Pratihar; Vishnu P Tripathi; Mukesh P Yadav; Dharani D Dubey


    Short, specific DNA sequences called as Autonomously Replicating Sequence (ARS) elements function as plasmid as well as chromosomal replication origins in yeasts. As compared to ARSs, different chromosomal origins vary greatly in their efficiency and timing of replication probably due to their wider chromosomal context. The two Schizosaccharomyces pombe ARS elements, ars727 and ars2OO4, represent two extremities in their chromosomal origin activity - ars727 is inactive and late replicating, while ars2OO4 is a highly active, early-firing origin. To determine the effect of chromosomal context on the activity of these ARS elements, we have cloned them with their extended chromosomal context as well as in the context of each other in both orientations and analysed their replication efficiency by ARS and plasmid stability assays. We found that these ARS elements retain their origin activity in their extended/altered context. However, deletion of a 133-bp region of the previously reported ars727-associated late replication enforcing element (LRE) caused advancement in replication timing of the resulting plasmid. These results confirm the role of LRE in directing plasmid replication timing and suggest that the plasmid origin efficiency of ars2OO4 or ars727 remains unaltered by the extended chromosomal context.

  1. CEBAF at higher energies: Working group report on hadron spectroscopy and production

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, T. [Oak Ridge National Laboratory, TN (United States)]| [Univ. of Tennessee, Knoxville (United States); Napolitano, J. [Rensselaer Polytechnic Inst., Troy, NY (United States)


    This report summarizes topics in hadron spectroscopy and production which could be addressed at CEBAF with an energy upgrade to E{sub {gamma}} = 8 GeV and beyond. The topics discussed include conventional meson and baryon spectrocopy, spectroscopy of exotica (especially molecules and hybrids), CP and CPT tests using {phi} mesons, and new detector and accelerator options.

  2. Giving to Excellence: Generating Philanthropic Support for UK Higher Education. Ross-CASE Report 2016 (United States)

    Jain, Yashraj


    This report presents findings from the 2016 Ross-CASE Survey of Philanthropic Giving to Universities in UK. The project was conducted by CASE Europe and funded by HEFCE and the Ross-Group. This year's survey comes at a time of great change for the UK charity sector. The historical trend data of previous surveys will be invaluable in helping…

  3. "Ars Electronica 2009" / Raivo Kelomees

    Index Scriptorium Estoniae

    Kelomees, Raivo, 1960-


    30. "Ars Electronica" festival "Human Nature" ("Inimese loomus") Linzis. Osaka ülikooli professori Hiroshi Ishiguro mehaanilis-digitaalsest nukust. Hübriidkunsti kategoorias peapreemia saanud Eduardo Kaci inimtaimest. Konverentsidest. Näitusest "See this Sound", mis oli pühendatud helile kujutavas kunstis

  4. "Ars Electronica 2009" / Raivo Kelomees

    Index Scriptorium Estoniae

    Kelomees, Raivo, 1960-


    30. "Ars Electronica" festival "Human Nature" ("Inimese loomus") Linzis. Osaka ülikooli professori Hiroshi Ishiguro mehaanilis-digitaalsest nukust. Hübriidkunsti kategoorias peapreemia saanud Eduardo Kaci inimtaimest. Konverentsidest. Näitusest "See this Sound", mis oli pühendatud helile kujutavas kunstis

  5. AR DOC: Augmented reality documentaries

    DEFF Research Database (Denmark)

    Vistisen, Peter


    Augmented Reality Documentaries (AR DOC) er et ’lille’ Shareplay projekt (ansøgte midler augmented reality cross media løsninger, til at skabe engagerende publikumsformidling...... indenfor oplevelsesindustrien. Projektet har genereret ny viden omkring, hvordan fysisk og digital formidling kan understøttes via Augmented Reality som formidlingsformat....

  6. USDA-ARS Quartlerly News (United States)

    This quarterly article is an update of research going on at The USDA-ARS Thad Cochran Southern Horticultural Laboratory in Poplarville, MS to be published in the Louisiana Nursery and Landscape Associations (LANLA) quarterly newsletter. This is one of three publications that I am sending out to the ...

  7. Flipped Classroom Implementation: A Case Report of Two Higher Education Institutions in the United States and Australia (United States)

    McLaughlin, Jacqueline E.; White, Paul J.; Khanova, Julia; Yuriev, Elizabeth


    This case report explored the implementation of flipped classrooms at two higher education institutions. Experiences and publications from the institutions were used to identify and describe common themes, including successes and challenges encountered along with potential solutions to common misalignments, particularly as related to…

  8. Higher Education in Further Education Colleges: Indirectly Funded Partnerships: Codes of Practice for Franchise and Consortia Arrangements. Report. (United States)

    Higher Education Funding Council for England, Bristol.

    This report provides codes of practice for two types of indirectly funded partnerships entered into by higher education institutions and further education sector colleges: franchises and consortia. The codes of practice set out guidance on the principles that should be reflected in the franchise and consortia agreements that underpin indirectly…

  9. Higher Reported Levels of Depression, Stress, and Anxiety Are Associated with Increased Endorsement of ADHD Symptoms by Postsecondary Students (United States)

    Harrison, Allyson G.; Alexander, Sandra J.; Armstrong, Irene T.


    This study examined the extent to which postsecondary students endorse symptoms of Attention Deficit/Hyperactivity Disorder (ADHD) and whether experienced level of stress, depression, or anxiety are associated with higher reporting of ADHD symptoms. Students attending a combined health and counseling service completed the Conners Adult ADHD Rating…

  10. Orthogonal Range Reporting: Query Lower Bounds, Optimal Structures in 3-d, and Higher Dimensional Improvements

    DEFF Research Database (Denmark)

    Afshani, Peyman; Arge, Lars Allan; Larsen, Kasper Dalgaard


    Orthogonal range reporting is the problem of storing a set of n points in d-dimensional space, such that the k points in an axis-orthogonal query box can be reported efficiently. While the 2-d version of the problem was completely characterized in the pointer machine model more than two decades ago...... data structure for the d-dimensional orthogonal range reporting problem in the pointer machine model of computation that uses S(n) space must spend Ω((log n/ log(S(n)/n))⌊d/2⌋--1) time to answer queries. Thus, if S(n)/n is poly-logarithmic, then the query time is at least Ω((log n/ log log n)⌊d/2......) to Ω((log n/ log log n)2 + k) somewhere between three and six dimensions. Finally, we show that our techniques also lead to improved structures for point location in rectilinear subdivisions, that is, the problem of storing a set of n disjoint d-dimensional axis-orthogonal rectangles...

  11. Book review: Advances in 40Ar/39Ar dating: From archaeology to planetary sciences (United States)

    Cosca, Michael A.


    The recently published book Advances in 40Ar/39Ar Dating: From Archaeology to Planetary Sciences is a collection of 24 chapters authored by international scientists on topics ranging from decay constants to 40Ar/39Ar dating of extraterrestrial objects. As stated by the editors in their introduction, these chapters were assembled with the goal of providing technique-specific examples highlighting recent advances in the field of 40Ar/39Ar dating. As this is the first book truly dedicated to 40Ar/39Ar dating since the second edition printing of the argon geochronologist’s handbook Geochronology and Thermochronology by the 40Ar/39Ar Method (McDougall and Harrison 1999), a new collection of chapters highlighting recent advances in 40Ar/39Ar geochronology offers much to the interested reader.

  12. Armenian Astronomical Society (ArAS) activities (United States)

    Mickaelian, A. M.


    A review on the activities and achievements of Armenian Astronomical Society (ArAS) and Armenian astronomy in general during the last years is given. ArAS membership, ArAS electronic newsletters (ArASNews), ArAS webpage, Annual Meetings, Annual Prize for Young Astronomers (Yervant Terzian Prize) and other awards, international relations, presence in international organizations, local and international summer schools, science camps, astronomical Olympiads and other events, matters related to astronomical education, astronomical heritage, amateur astronomy, astronomy outreach and ArAS further projects are described and discussed.

  13. Regulation of chloroplast number and DNA synthesis in higher plants. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Mullet, J.E.


    The long term objective of this research is to understand the process of chloroplast development and its coordination with leaf development in higher plants. This is important because the photosynthetic capacity of plants is directly related to leaf and chloroplast development. This research focuses on obtaining a detailed description of leaf development and the early steps in chloroplast development including activation of plastid DNA synthesis, changes in plastid DNA copy number, activation of chloroplast transcription and increases in plastid number per cell. The grant will also begin analysis of specific biochemical mechanisms by isolation of the plastid DNA polymerase, and identification of genetic mutants which are altered in their accumulation of plastid DNA and plastid number per cell.

  14. Regulation of chloroplast number and DNA synthesis in higher plants. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Mullet, J.E.


    The long term objective of this research is to understand the process of chloroplast development and its coordination with leaf development in higher plants. This is important because the photosynthetic capacity of plants is directly related to leaf and chloroplast development. This research focuses on obtaining a detailing description of leaf development and the early steps in chloroplast development including activation of plastid DNA synthesis, changes in plastid DNA copy number, activation of chloroplast transcription and increases in plastid number per cell. The grant will also begin analysis of specific biochemical mechanisms by isolation of the plastid DNA polymerase, and identification of genetic mutants which are altered in their accumulation of plastid DNA and plastid number per cell.

  15. Higher Education of Specialists of Social Rehabilitation – Reports from Research

    Directory of Open Access Journals (Sweden)

    Justyna Kusztal


    Full Text Available The article is a another opinion in the matter of the education of the students of social rehabilitation. In 2012, on the pages of “Resocjalizacja Polska”, came out an article about contemporary status of the social rehabilitation educator and the process of his education in the era of the reform of higher education. The current text is the continuation of this article and also a presentation of an explorative sense and thoughts of the participants of the project, realized since 2011 within the statutory research of the Department of Social Prevention and Rehabilitation in Institiute of Pedagog y in Jagiellonian University and Department of Social Prevention and Rehabilitation in Institiute of Education in Jesuit University in Cracow.

  16. Ar-40/Ar-39 age spectra of Apollo 15 impact melt rocks by laser step-heating and their bearing on the history of lunar basin formation (United States)

    Dalrymple, G. B.; Ryder, Graham


    Results are reported on 26 high-resolution (16-51 steps) Ar-40/Ar-39 age spectra obtained on 12 Apollo-15 melt rocks of different composition using a continuous laser system on submg fragments of recrystallized melt and single-crystal plagioclase clasts from impact melt rocks collected at the Apennine Front where the Imbrium and Serenitatis basins intersect. A table is presented with the summary of the Ar-40/Ar-39 spectrum data, which represent 891 individual temperature step analyses. Also presented are 20 of the 26 age spectra along with their respective K/Ca plots. Melt rock fragments and plagioclase clasts from seven of the 12 samples analyzed yielded reproducible, intermediate-T Ar-40/Ar-39 age spectrum plateaus, which were interpreted as crystallization ages that represent the times of impact of bolides onto the lunar surface.

  17. ar

    Directory of Open Access Journals (Sweden)

    P. Fanlo

    Full Text Available A pesar de que el pulmón es el órgano diana por excelencia de la tuberculosis, cualquier otro órgano y sistema puede verse afectado. En este trabajo se revisan las formas de tuberculosis extrapulmonar a excepción de la pleural que requieren del facultativo, en ocasiones, su más valiosa pericia diagnóstica. Desde la temida meningitis tuberculosa, pasando por la afectación insidiosa de la espondilodiscitis, la llamativa afectación ganglionar, la afectación genitourinaria, la pericarditis, para terminar las formas menos frecuentes como la ocular o la cutánea. En cada apartado indicaremos lo más característico con la finalidad de que pueda servir de orientación diagnóstica y terapéutica.

  18. ARS - Helsinki - 2006 / Galina Balashova

    Index Scriptorium Estoniae

    Balashova, Galina


    Steven Holli projekteeritud Kiasma muuseumihoonest Helsingis. Kontseptuaalkunsti näitusest ARS 06 "Reaalsustunne" Kiasmas. Eestlastest esineb Mark Raidpere. Vene kunstnikegrupi AEC+F ja vene kunstnike Juri Vassiljevi ning Aleksandr Ponomarjovi töödest näitusel. Ka Gerda Steineri & Jörg Lenzlingeri (Šveits), Martin & Munoz'i (USA, Hispaania), arvutigraafik Charles Sandisoni (SB), videokunstnik Bill Viola (USA) jt. töödest

  19. ARS - Helsinki - 2006 / Galina Balashova

    Index Scriptorium Estoniae

    Balashova, Galina


    Steven Holli projekteeritud Kiasma muuseumihoonest Helsingis. Kontseptuaalkunsti näitusest ARS 06 "Reaalsustunne" Kiasmas. Eestlastest esineb Mark Raidpere. Vene kunstnikegrupi AEC+F ja vene kunstnike Juri Vassiljevi ning Aleksandr Ponomarjovi töödest näitusel. Ka Gerda Steineri & Jörg Lenzlingeri (Šveits), Martin & Munoz'i (USA, Hispaania), arvutigraafik Charles Sandisoni (SB), videokunstnik Bill Viola (USA) jt. töödest

  20. Ars Industrialis,

    Directory of Open Access Journals (Sweden)

    Frédérique Mingant


    Full Text Available The website was created in 2005, when the association Ars Industrialis came into being. The association was founded by a group of philosophers and jurists, on the initiative of philosopher Bernard Stiegler, the former director of the IRCAM (Institut de Recherche et Coordination Acoustique/Musique–Institute of Research and Coordination on Acoustic/Music and the current director of the Department of cultural development at the Centre Georges Pompidou (French National Arts C...

  1. Ars Industrialis,


    Frédérique Mingant


    The website was created in 2005, when the association Ars Industrialis came into being. The association was founded by a group of philosophers and jurists, on the initiative of philosopher Bernard Stiegler, the former director of the IRCAM (Institut de Recherche et Coordination Acoustique/Musique–Institute of Research and Coordination on Acoustic/Music) and the current director of the Department of cultural development at the Centre Georges Pompidou (French National Arts C...

  2. Ar-40/Ar-39 Ages for Maskelynites and K-Rich Melt from Olivine-Rich Lithology in (Kanagawa) Zagami (United States)

    Park, J.; Herzog, G. F.; Nyquist, L. E.; Lindsay, F.; Turrin, B.; Swisher, C. C., III; Delaney, J. S.; Shih, C.-Y.; Niihara, T.; Misawa, K.


    We report Ar/Ar release patterns for small maskelynite grains and samples of a K-rich phase separated from the basaltic shergottite Zagami. The purpose of the work is to investigate the well-known discrepancy between published Ar/Ar ages of Zagami, >200 Ma, and its age of approx. 170 Ma as determined by other methods [1-6]. Niihara et al. [7] divide less abundant darker material present in Zagami into an olivine-rich lithology (ORL), from which most of our samples came, and a pyroxene-rich one (Dark Mottled-Lithology: DML) [8, 9]. ORL consists of vermicular fayalitic olivine, coarse-grained pyroxene, maskelynite, and a glassy phase exceptionally rich in K (up to 8.5 wt%), Al, and Si, but poor in Fe and Mg. The elemental composition suggests a late-stage melt, i.e., residual material that solidified late in a fractional crystallization sequence. Below we refer to it as "K-rich melt." The K-rich melt contains laths of captured olivine, Ca-rich pyroxene, plagioclase, and opaques. It seemed to offer an especially promising target for Ar-40/Ar-39 dating.

  3. Improvement of the structure of reports of Ukrainian higher educational institutions in terms of deregulation and state authority decentralization

    Directory of Open Access Journals (Sweden)

    V.S. Ambarchian


    Full Text Available Improvement of the structure and content of financial and budgetary reports of domestic higher educational institutions, enhance of financial statements completeness in order to enable citizens to control a university activity. During the research both general scientific and specific scientific economic methods were implemented. The general methods include induction, deduction, analogy and comparison. Among specific methods of economic research grouping, table method, graphical method, method of informational and logical analysis were used. The paper characterizes legal documents which regulate the process of university financial statements preparation and presentation in different countries. Financial reports of Ukrainian, American and British universities are compared. The author determines the major directions of improvement of the structure and content of domestic university reports with the purpose of their completeness enhancing. As a result of the research performed the proper recommendations of improvement of domestic universities reporting are suggested. The author conforms the reporting information with the Managerial report which discloses the information about the reporting period achievements and the efficiency of budget resources expenditure.

  4. Occurrences of Excess 40Ar in Hydrothermal Tourmaline:Interpretations from 40Ar-39Ar Dating Results by Stepwise Heating

    Institute of Scientific and Technical Information of China (English)

    QIU Huaning; PU Zhiping; DAI Tongmo


    The occurrences of excess 40Ar within a hydrothermal tourmaline is discussed in term of the analysis data of syngenetic muscovite and tourmaline from the Lushui hydrothermal tin-tungsten deposit in western Yunnan, China, using the 40Ar-39Ar stepwise heating technique. About 80% excess 40Ar was released in the last step when the tourmaline was fused, corresponding to a release of only ~3% 39Ar (K), which indicates that most excess 40Ar was held in the mineral lattice rather than in the channels parallel to the Z-axis. This suggests that the excess 40Ar was incorporated during crystallization and not diffused into the tourmaline during the post-crystallization history.

  5. Ars Memorativa, Ars Oblivionis in Middle English Religious Plays

    Directory of Open Access Journals (Sweden)

    Ciobanu Estella Antoaneta


    Full Text Available This paper investigates the multi-layered violence of religious representation in the late medieval York biblical plays, with a focus on the Supper at Emmaus. I read Emmaus (Y40, a play which commemorates the Crucifixion and openly encourages strong anti-Judaism, alongside scenes in an early predecessor pageant, The Crucifixion (Y35, within their contemporary devotional and mnemonic practices, i.e. the confessional Book of Margery Kempe and Thomas Bradwardine’s tract on ars memorativa. Emmaus in particular demonstrates how a fundamentally violent ars memorativa, the legacy of ancient rhetoric to the Middle Ages, also underpins the instruction of the laity in the basics of Christian faith, here with the aid of highly musical prosody and repetition, and thereby hones a biased, intolerant and violence-inured Christian collective memory. To study the York play’s position relative to late medieval mnemonic practices, I frame my analysis within memory studies, enriched with the more specific insights offered by social-psychological, neurobiological and cognitivist studies of memory.

  6. 穿膜肽AR-23增强聚乙烯亚胺介导的基因转染效率及其机制的初步研究%Effect of positively charged residues at C-terminal of AR-23 on improvement of polyethylenimine-mediated gene transfection

    Institute of Scientific and Technical Information of China (English)

    马倩; 檀英霞; 王颖丽; 李素波; 高红伟; 鲍国强; 季守平


    was evaluated using green fluorescence protein ( GFP) and luciferase as reporter genes . The viability of transfected cells was evaluated by MTT assay . Results In the mimetic membrane environment , AR-23 showed typical α-helical structure in which the α-helical content was 37.6% , but AR-20 did not present α-helical conformation. AR-23 exhibited concentration -dependent hemolysis under both neutral and acidic conditions , but AR-20 did not have hemolytic activity. Compared to AR-20, cell membrane was efficiently depolarized by AR -23. Trans fection results showed that luciferase activity and GFP expression in AR -23 /PEI/DNA transfected cells were higher than in PEI /DNA group in both HeLa and RAW264. 7 cells. Compared with PEI transfected group , AR-23 group had higher cell viability in HeLa and RAW264. 7cells. Conclusion The positively charged residues at C-terminal of AR-23 play an important role in maintaining a-helical conformation and membrane penetrating activity . Furthermore, PEI mediated transfection can be effectively improved by AR-23 without causing significant cytotoxicity. Therefore, AR-23 may be considered a potential enhancer of cationic polymers mediated transfection efficiency.

  7. Brief report: social and communication abilities and disabilities in higher functioning individuals with autism and Asperger syndrome. (United States)

    Saulnier, Celine A; Klin, Ami


    Individuals with higher functioning autism (HFA) fail to translate their cognitive potential into real-life adaptation, and the severity of their symptoms is considerable despite their intellectual ability. This paper reports on a subsample from a larger study (A. Klin et al., in press) analyzed here by autism spectrum subtypes. It focuses on the nature of ability and disability in HFA and Asperger syndrome (AS) in relation to age and IQ. Participants included 32 individuals with autism and 35 with AS. Individuals with AS had significantly higher Verbal IQ scores and less symptomatology than individuals with autism, but their Vineland scores were equally impaired, highlighting the adaptive deficits in ASD regardless of classification. No relationship was found between adaptive functioning and symptom severity.

  8. New SHRIMP U-Pb and 40Ar/39Ar constraints on the crustal stabilization of southern South America, from the margin of the Rio de Plata (Sierra de Ventana) craton to northern Patagonia (United States)

    Tohver, E.; Cawood, P. A.; Rossello, E.; Lopez de Luchi, M. G.; Rapalini, A.; Jourdan, F.


    Two models exist to explain the late Paleozoic tectonic history for southern South America: an accretionary model of crustal growth through magmatism and a collisional model involving pre-existing continental elements, namely, the Rio de Plata craton and the possibly allochthonous terrane(s) of Patagonia, the Northern Patagonia Massif and the Deseado Massif. We report new U-Pb and 40Ar/39Ar results from rocks within a posited collision zone between the SW edge of the Rio de Plata craton and the northern margin of the Northern Patagonia Massif. Igneous basement samples from the Sierra de Ventana region, Buenos Aires province, were dated by ion microprobe (SHRIMP) analysis of zircon. A previously unrecognized occurrence of Paleoproterozoic basement indicates that the Rio de Plata craton extends ca.250 km farther west than considered. The majority of the basement rocks are shallow mid-Cambrian granitoids and rhyolites, including the rocks of the Cerro Colorado granite, which is intrusive into the sediments of the Curamalal Gp, signifying that these mature quartzites and conglomerates are older than early Cambrian in age, possibly correlated with the low-grade sedimentary rocks of the Tandilia Range that includes the La Tinta Fm. The 40Ar/39Ar ages from biotite, muscovite, and sericite from three different sheared basement localities demonstrates deformation in the latest Permian (265-260 Ma), ca. 20 Ma after the foreland deposition of the synorogenic Tunas Fm. in the upper Pilahuinco Gp, constrained by 282.4 ± 2.8 Ma zircon ages in volcanic ashbeds. Farther south, along the northern margin of the Northern Patagonian Massif, late Ordovician 40Ar/39Ar cooling ages of granites intrusive into the Cambro-Ordovician Nahuel Niyeu Fm. are consistent with the presence of Ordovician magmatism along the W edge of the Rio de Plata craton. These ages alternate with late Permian 40Ar/39Ar cooling ages from undeformed granites and pegmatites, as well as early Jurassic cross

  9. Evaluation of higher distribution and/or utilization voltages. Fourth interim report (August 1980): assessment of optimum distribution configuration

    Energy Technology Data Exchange (ETDEWEB)


    This interim report provides documentation on the fourth task, Assessment of Optimum Distribution Configuration, of DOE Contract No. ET-78-C-01-2866, Evaluation of Higher Distribution and/or Utilization Voltages. The work performed under this task includes the development of a computer model for assessment of life cycle costs for the distribution and utilization systems, the development of an optimization algorithm to enable distribution system configuration optimization and a net energy analysis to determine potential net energy savings. Input data for this task derive from Task 3. The major output of this task is a documented computer code.

  10. Modified A{sup ++}-standard refrigerator with 30% reduction of energy consumption. Higher efficiency by compressor modification - Final report

    Energy Technology Data Exchange (ETDEWEB)

    Siegrist, M.; Stahl, S.; Ganz, J.


    This final report for the Swiss Federal Office of Energy (SFOE) takes a look at how a modified refrigerator can be given a higher efficiency by modifying the compressor. The modified refrigerator was fitted with a variable-speed compressor. This compressor could be run at much lower speeds so that it was in operation for up to 90% of the time. It was shown that less electricity was consumed the more the compressor ran. The report discusses the aims of the work and presents details on the standard refrigerator used for the tests. The compressor normally used and the variable-speed compressor used in the test are described. Systems for temperature control and data acquisition during the tests are described. The results obtained are examined and the influence of various factors is discussed.

  11. Total Quality Management in Higher Education: Clearing the Hurdles. A Survey on Strategies for Implementing Quality Management Practices in Higher Education. A GOAL/QPC Application Report. (United States)

    Seymour, Daniel

    Based on a survey of Quality Management (QM) practitioners at 21 colleges, this study presents the 10 most difficult implementation hurdles to QM in higher education and a set of hurdle-clearing strategies. The hurdles are: (1) lack of time to implement QM; (2) perception that QM is something for janitorial and housing staffs but not applicable to…

  12. Bilingual Higher Education Summer Institute. Bilingual Higher Education: Foundations, Policy, and Practice. Report of Proceedings (Seton Hall University, August 24-29, 1979). (United States)

    Cotayo, Rosa Maria, Ed.

    Papers are presented from the New Jersey Department of Higher Education Summer Institute. Focus is on sociolinguistic, anthropological, social psychological, pedagogical, and socio-political-economic considerations. Each analyzes particular factors that influence the form and quality of bilingual policy and instruction programs, and offers…

  13. Total Quality Management in Higher Education: Clearing the Hurdles. A Survey on Strategies for Implementing Quality Management Practices in Higher Education. A GOAL/QPC Application Report. (United States)

    Seymour, Daniel

    Based on a survey of Quality Management (QM) practitioners at 21 colleges, this study presents the 10 most difficult implementation hurdles to QM in higher education and a set of hurdle-clearing strategies. The hurdles are: (1) lack of time to implement QM; (2) perception that QM is something for janitorial and housing staffs but not applicable to…

  14. The Path to Excellence: Quality Assurance in Higher Education. ASHE-ERIC Higher Education Research Reports, No. 1. FYI Executive Summary. (United States)

    Marcus, Lawrence R.; And Others

    There is an increasing interest by government in accountability for higher education. Efforts such as performance budgeting, performance auditing, and state review of academic programs are becoming more common. Opponents of government involvement assert that regional accreditation reviews are sufficient to maintain quality standards. However,…

  15. The Uses of Institutional Culture: Strengthening Identification and Building Brand Equity in Higher Education. ASHE Higher Education Report, Volume 31, Number 2 (United States)

    Toma, J. Douglas, Ed.; Dubrow, Greg, Ed.; Hartley, Matthew, Ed.


    Institutional culture matters in higher education, and universities and colleges commonly express the need to strengthen their culture. A strong culture is perceived, correctly so, to engender a needed sense of connectedness between and among the varied constituents associated with a campus. Linking organizational culture and social cohesion is…

  16. Additional 40Ar- 39Ar dating of the basement and the alkaline volcanism of Gorringe Bank (Atlantic Ocean) (United States)

    Féraud, Gilbert; York, Derek; Mével, Catherine; Cornen, Guy; Hall, Chris M.; Auzende, Jean-Marie


    40Ar/ 39Ar step heating analyses are reported for a variety of samples from Gorringe Bank (Atlantic Ocean). Flat age spectra for two primary, igneous hornblendes of Gorringe (corresponding to an age of 143 Ma) show that the K-Ar ages obtained on these samples by Prichard and Mitchell [4] are evidently crystallization and not hybrid ages. This sustains the concept of an initiation age of 140 Ma [4] for Gorringe Bank. No support is found for Carpena's suggestion [7] that the formation of Gorringe Bank began 200 Ma ago. Secondary hornblendes from Ormonde seamount rocks appear to have formed shortly after the initiation of the Bank. Precise plateau ages on samples of two alkaline volcanics from Ormonde correspond to the older limit of the alkaline volcanism suggested by Féraud et al. [3,5].

  17. Ars grammatica de Dionisio Tracio

    Directory of Open Access Journals (Sweden)

    Beltrán Jorge Enrique


    Full Text Available

    Ars Grammatica de Dionisio Tracio (170-90 a. C fue la primera gramática griega que se escribió. Su contenido y método fueron modelos que siguieron las gramáticas escolares posteriores. La versión española que se presenta ahora responde a la necesidad que se tenía en nuestro medio de una traducción completa de este texto. Finalmente, se acompaña la traducción de una introducción y de abundantes notas, en un intento por hacerla comprensible para el hablante del español, no necesariamente conocedor de la lengua griega.

  18. Time and Spectrally Resolved Fluorescence of Cl*2 and ArCl* in Cl2 Doped Ar Under State Selective Pulsed Photoexcitation with Synchrotron Radiation (United States)

    Möller, T.; Jordan, B.; Zimmerer, G.; Haaks, D.; Le Calvé, J.; Castex, M.-C.


    Synchrotron Radiation is used to selectively excite chlorine and Cl2 doped argon in the VUV region. Stationary fluorescence and excitation spectra of the 11Σ{/u +}, 21Σ{/u +} and 23Π g Cl{2/*} states and of the ArCl*( B-X) transition are obtained. The excitation threshold of ArCl*( B) in Ar/Cl2 system is found to be 1,285±5 Å and that of ArCl( C) at ˜1,260 Å. The formation of ArCl* and Cl*2(23Π g) is discussed in terms of recent potential curves data. A detailed time resolved study is reported which allows us to determine precisely the radiative lifetime of ArCl*( B) state (5.2 ns) and numerous kinetic parameters of this system, to estimate the C state energy and to discuss the relaxation and mixing process of the ArCl*( B) and ( C) states. A two ladder multilevel kinetic model is described which accounts for the experimental results and shows the difficulty of studying this particular ArCl* system as compared to the closely related XeCl* and KrCl* ones.

  19. GPS-Based AR Games Development Potential

    Directory of Open Access Journals (Sweden)

    Gregorius Alvin Raditya Santoso


    Full Text Available The application of new technologies in a game is not a new thing. One example is the application of Augmented Reality (AR technology in game. Many people do not know the application of AR technology in game, although the application of this technology is able to produce a game with unique gameplay. In addition, since AR game is GPS-based, it offers new gaming experience, that is, playing outdoors in which the real world becomes the game arena. This advantage gives the AR technology a huge potential to be developed into a game

  20. Langmuir Probe Measurements of Inductively Coupled CHF3/Ar and Ar/CHF3/O2 Plasmas (United States)

    Sharma, S. P.; Rao, M. V. V. S.; Meyyappan, M.


    Plasma parameters, such as, electron number density (ne), electron temperature (Te), y electron energy distribution function (EEDF), mean electron energy (Ee), ion number density (ni), and plasma potential (Vp), have been measured by using Langmuir probe in low-pressure (10-50 mTorr) inductively coupled CHF3/Ar and CHF3/Ar/O2 plasmas generated in the GEC cell. The measurements were made at the center of the plasma, keeping the lower electrode grounded, for various CHF3/Ar and Ar/CHF3/O2 mixtures operating at 10-50 mTorr pressures and two input RF power levels, 200 and 300 W. EEDF data show a strong Druyvesteyn distribution with relatively lower number of low energy electrons as compared to a Maxwell distribution and a large electron population with energies higher than the plasma potential. The results further show that at low CHF3 concentrations (less than 50%) the electron number density remains nearly constant with increase in pressure. At higher CHF3 concentrations, however, it decreases with increase in pressure. Plasma potential and electron temperature increase with decrease in pressure and with increase in CHF3 concentration. An analysis of the above observations and mechanisms will be presented.

  1. 40Ar/39Ar Interlaboratory Calibration into the Holocene. (United States)

    Heizler, M. T.; Jicha, B.; Koppers, A. A. P.; Miggins, D. P.


    Advances in 40Ar/39Ar analytical precision for very young rocks requires collaborative efforts amongst argon geochronology labs to demonstrate age reproducibility commensurate with high precision. NM Tech (NMT), the University of Wisconsin (UW) and Oregon State University (OSU) have each dated Quaternary flux monitor standard AC-2 sanidine (~1.185 Ma), a blind sanidine described as being 50-100 ka (BS) and sanidine from the Qixiangshan (QIX) flow (~10 ka), Changbaishan volcano, China. The samples were irradiated in a single package with FC-2 sanidine (28.201 Ma) as the flux monitor and the irradiated material was distributed amongst the labs. Heizler was present during analysis at both OSU and UW and Jicha attended OSU during analysis. Physical presence was key towards gaining understanding of individual protocols and prompted valuable discussions. Analyses were carried out on single crystals using total fusion and/or step heating approaches. Age agreement was achieved within 2s uncertainty that ranged between (0.03-0.3%, 0.13-0.37% and 1.8-2.6%) for AC-2, BS and QIX, respectively. Each lab found AC-2 to vary somewhat beyond a normal distribution and to yield an age relative to FC-2 of ~1.185 Ma that is ~1.3% (~5-10 sigma) lower than some published estimates. A key cause of the variation between this study and previous results may be variable gas pressure equilibration times between extraction line and mass spectrometer coupled with variable choices to estimate time zero by other laboratories. The majority of our efforts concentrated on the QIX sanidine where prior data obtained by our labs revealed a factor of two spread in age (~11 and 23 ka) based on experiments carried out by total fusion and bulk incremental heating. By conducting single crystal age spectrum analysis we were able to mitigate effects of melt inclusion hosted excess argon and xenocrystic contamination towards obtaining analytical agreement with apparent ages near 10 ka. However, philosophical

  2. ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for adenosylcobamide biosynthesis. (United States)

    Chan, Chi Ho; Escalante-Semerena, Jorge C


    In the homoacetogenic bacterium Sporomusa ovata, phenol and p-cresol are converted into α-ribotides, which are incorporated into biologically active cobamides (Cbas) whose lower ligand bases do not form axial co-ordination bonds with the cobalt ion of the corrin ring. Here we report the identity of two S. ovata genes that encode an enzyme that transfers the phosphoribosyl group of nicotinate mononucleotide (NaMN) to phenol or p-cresol, yielding α-O-glycosidic ribotides. The alluded genes were named arsA and arsB (for alpha-ribotide synthesis), arsA and arsB were isolated from a genomic DNA library of S. ovata. A positive selection strategy using an Escherichia coli strain devoid of NaMN:5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) activity was used to isolate a fragment of S. ovata DNA that contained arsA and arsB, whose nucleotide sequences overlapped by 8 bp. SoArsAB was isolated to homogeneity, shown to be functional as a heterodimer, and to have highest activity at pH 9. SoArsAB also activated DMB to its α-N-glycosidic ribotide. Previously characterized CobT-like enzymes activate DMB but do not activate phenolics. NMR spectroscopy was used to confirm the incorporation of phenol into the cobamide, and mass spectrometry was used to identify SoArsAB reaction products. © 2011 Blackwell Publishing Ltd.

  3. Androgen receptor and its splice variant, AR-V7, differentially regulate FOXA1 sensitive genes in LNCaP prostate cancer cells. (United States)

    Krause, William C; Shafi, Ayesha A; Nakka, Manjula; Weigel, Nancy L


    Prostate cancer (PCa) is an androgen-dependent disease, and tumors that are resistant to androgen ablation therapy often remain androgen receptor (AR) dependent. Among the contributors to castration-resistant PCa are AR splice variants that lack the ligand-binding domain (LBD). Instead, they have small amounts of unique sequence derived from cryptic exons or from out of frame translation. The AR-V7 (or AR3) variant is constitutively active and is expressed under conditions consistent with CRPC. AR-V7 is reported to regulate a transcriptional program that is similar but not identical to that of AR. However, it is unknown whether these differences are due to the unique sequence in AR-V7, or simply to loss of the LBD. To examine transcriptional regulation by AR-V7, we have used lentiviruses encoding AR-V7 (amino acids 1-627 of AR with the 16 amino acids unique to the variant) to prepare a derivative of the androgen-dependent LNCaP cells with inducible expression of AR-V7. An additional cell line was generated with regulated expression of AR-NTD (amino acids 1-660 of AR); this mutant lacks the LBD but does not have the AR-V7 specific sequence. We find that AR and AR-V7 have distinct activities on target genes that are co-regulated by FOXA1. Transcripts regulated by AR-V7 were similarly regulated by AR-NTD, indicating that loss of the LBD is sufficient for the observed differences. Differential regulation of target genes correlates with preferential recruitment of AR or AR-V7 to specific cis-regulatory DNA sequences providing an explanation for some of the observed differences in target gene regulation.

  4. Polineuropatia periférica arsenical: tratamento com penicilamina. Dosagem de arsênico inorgânico em nervo periférico, sangue e urina Arsenical peripheral polyneuropathy: treatment with penicillamine and determination of the concentrations of inorganic arsenic in peripheral nerve, blood, and urine. A case report

    Directory of Open Access Journals (Sweden)

    Abrão Anghinah


    Full Text Available Os autores registram caso de paciente na qual, após intoxicação aguda por arsênico inorgânico, instalou-se quadro de polineuropatia periférica. Foram verificadas altas concentrações de arsênico no nervo periférico estudado (1,48 mg/100 g peso seco, e 0,49 mg/100 g peso fresco e na urina. Antes do tratamento com penicilamina a quantidade de arsênico excretada na urina era de 80,0 micro/100 ml; após 7 dias de tratamento a excreção passou a ser de 150,2 micrograma/100 ml. Estes resultados bioquímicos foram acompanhados de progressiva melhora clínica.Report of a case of acute intoxication by inorganic arsenic with a picture of peripheral polyneuropathy. High concentrations of arsenic were found in the peripheral nerve studied (1.48 mg/100 g fresh tissue; 0,40 mg/100 g dry tissue blood and urine. Before the treatment with penicillamine the urinary concentration of arsenic was 80,0 micrograms/100 ml; 7 days after the onset of treatment the excretion increased to 150.2 micrograms/100 ml. Improvement of the clinical conditions was parallel to these biochemical results.

  5. Modification of stearic acid in Ar and Ar-O2 pulsed DC discharge

    Directory of Open Access Journals (Sweden)

    Euclides Alexandre Bernardelli


    Full Text Available Stearic acid (CH3(CH216COOH was treated with Ar and Ar-O2 (10% pulsed DC discharges created by a cathode-anode confined system to elucidate the role of oxygen in plasma cleaning. The treatment time (5 to 120 minutes and plasma gas mixture (Ar and Ar-O2 were varied, and the results showed that the mass variation of stearic acid after Ar-O2 plasma exposure was greater than that of pure Ar plasma treatment. Thus, compared to Ar*, active oxygen species (O and O2, in all states enhance the etching process, regardless of their concentration. During the treatments, a liquid phase developed at the melting temperature of stearic acid, and differential thermal analyses showed that the formation of a liquid phase was associated with the breakage of bonds due to treatment with an Ar or Ar-O2 plasma. After treatment with Ar and Ar-O2 plasmas, the sample surface was significantly modified, especially when Ar-O2 was utilized. The role of oxygen in the treatment process is to break carbonaceous chains by forming oxidized products and/or to act as a barrier again ramification, which accelerates the etching of stearic acid.

  6. Higher prevalence of exercise-associated hyponatremia in triple iron ultra-triathletes than reported for ironman triathletes. (United States)

    Rüst, Christoph Alexander; Knechtle, Beat; Knechtle, Patrizia; Rosemann, Thomas


    "In a recent study of male and female ultra-marathoners in a 161-km ultra-marathon, the prevalence of exercise-associated hyponatremia (EAH) was higher than reported for marathoners. Regarding triathletes, the prevalence of EAH has been investigated in Ironman triathletes, but not in Triple Iron ultra-triathletes. The aim of this study was to investigate the prevalence of EAH in male ultra-triathletes competing in a Triple Iron ultra-triathlon over 11.4 km swimming, 540 km cycling, and 126.6 km running. Changes in body mass, fat mass, skeletal muscle mass, total body water, haematocrit, plasma volume, plasma sodium concentration ([Na ⁺ ]) and urine specific gravity were determined in 31 male athletes with (means ± standard deviation) 42.1 ± 8.1 years of age, 77.0 ± 7.0 kg body mass, 1.78 ± 0.06 m body height and a BMI of 24.3 ± 1.7 kg/m² in the 'Triple Iron Triathlon Germany'. Of the 31 finishers, eight athletes (26%) developed asymptomatic EAH. Body mass, fat mass, skeletal muscle mass, and haematocrit decreased, plasma volume increased ( P Iron ultra-triathletes compared to existing reports on Ironman triathletes. Body fluid homeostasis remained stable in these ultra-triathletes although body mass decreased."

  7. Surface modification and biocompatible improvement of polystyrene film by Ar, O{sub 2} and Ar + O{sub 2} plasma

    Energy Technology Data Exchange (ETDEWEB)

    Chen Yashao, E-mail: [Key Laboratory of Applied Surface and Colloid Chemistry (Shaanxi Normal University), Ministry of Education, School of Chemistry and Chemical Engineering, Xi' an 710062 (China); Gao Qiang; Wan Haiyan; Yi Jinhong; Wei Yanlin [Key Laboratory of Applied Surface and Colloid Chemistry (Shaanxi Normal University), Ministry of Education, School of Chemistry and Chemical Engineering, Xi' an 710062 (China); Liu Peng [Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, College of Bioengineering, Chongqing 400044 (China)


    Highlights: Black-Right-Pointing-Pointer NVP is successfully grafted onto the different discharge gases (Ar, O{sub 2}, and Ar + O{sub 2}) plasma-treated PS film surface by Ar plasma induced graft polymerization. Black-Right-Pointing-Pointer Compare with Ar and O{sub 2} plasma, the Ar + O{sub 2} plasma-treated film surface introduced large amounts of NVP, as known from ATR-FTIR and XPS results. Black-Right-Pointing-Pointer According to SEM, the surface roughness increased at different levels after plasma treatment. Contact angle reveal that the hydrophilicity of the PS film surface was greatly improved. Black-Right-Pointing-Pointer Cellular compatibility tests indicate that Ar + O{sub 2} plasma is more capable of increasing cell adhesion and proliferation. - Abstract: This paper reports the surface modification of different discharge gases (Ar, O{sub 2}, and Ar + O{sub 2}) plasma-treated polystyrene (PS) film by Ar plasma induced graft polymerization, with biocompatible monomer N-vinyl-2-pyrrolidone (NVP) is carried out to improve biocompatibility. The films are characterized by attenuated total reflectance Fourier transfer infrared (ATR-FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). Water contact angle measurement demonstrates the modified films possess a relatively hydrophilic surface. Furthermore, the films are also examined cell attachment and proliferation in vitro using mouse fibroblasts (L929 cells). The modified film surface shows a better cell distribution and growth than that of the pristine PS surface. From cell culture experiments, it is also observed that Ar + O{sub 2} plasma is more capable of increasing cell adhesion and proliferation. This method will provide a potential and effective solution for grafting useful component in future tissue-engineering applications.

  8. Study of the symbiotic star AR Pavonis

    Directory of Open Access Journals (Sweden)

    C. Quiroga


    Full Text Available We present a study of the optical spectra and linear polarization of the eclipsing binary AR Pavonis. The optical spectra were obtained between 1990 and 1998, and polarimetric data between 1995 and 1998. From spectroscopic variations along the orbital motion we analized the nature of the system. Polarimetric studies indicate that AR Pav has intrinsic polarization.

  9. Higher Drop in Speed during a Repeated Sprint Test in Soccer Players Reporting Former Hamstring Strain Injury. (United States)

    Røksund, Ola D; Kristoffersen, Morten; Bogen, Bård E; Wisnes, Alexander; Engeseth, Merete S; Nilsen, Ann-Kristin; Iversen, Vegard V; Mæland, Silje; Gundersen, Hilde


    Aim: Hamstring strain injury is common in soccer. The aim of this study was to evaluate the physical capacity of players who have and have not suffered from hamstring strain injury in a sample of semi-professional and professional Norwegian soccer players in order to evaluate characteristics and to identify possible indications of insufficient rehabilitation. Method: Seventy-five semi-professional and professional soccer players (19 ± 3 years) playing at the second and third level in the Norwegian league participated in the study. All players answered a questionnaire, including one question about hamstring strain injury (yes/no) during the previous 2 years. They also performed a 40 m maximal sprint test, a repeated sprint test (8 × 20 m), a countermovement jump, a maximal oxygen consumption (VO2max) test, strength tests and flexibility tests. Independent sample t-tests were used to evaluate differences in the physical capacity of the players who had suffered from hamstring strain injury and those who had not. Mixed between-within subject's analyses of variance was used to compare changes in speed during the repeated sprint test between groups. Results: Players who reported hamstring strain injury during the previous two years (16%) had a significantly higher drop in speed (0.07 vs. 0.02 s, p = 0.007) during the repeated sprint test, compared to players reporting no previous hamstring strain injury. In addition, there was a significant interaction (groups × time) (F = 3.22, p = 0.002), showing that speed in the two groups changed differently during the repeated sprint test. There were no significant differences in relations to age, weight, height, body fat, linear speed, countermovement jump height, leg strength, VO2max, or hamstring flexibility between the groups. Conclusion: Soccer players who reported hamstring strain injury during the previous 2 years showed significant higher drop in speed during the repeated sprint test compared to players with no hamstring

  10. Higher Drop in Speed during a Repeated Sprint Test in Soccer Players Reporting Former Hamstring Strain Injury (United States)

    Røksund, Ola D.; Kristoffersen, Morten; Bogen, Bård E.; Wisnes, Alexander; Engeseth, Merete S.; Nilsen, Ann-Kristin; Iversen, Vegard V.; Mæland, Silje; Gundersen, Hilde


    Aim: Hamstring strain injury is common in soccer. The aim of this study was to evaluate the physical capacity of players who have and have not suffered from hamstring strain injury in a sample of semi-professional and professional Norwegian soccer players in order to evaluate characteristics and to identify possible indications of insufficient rehabilitation. Method: Seventy-five semi-professional and professional soccer players (19 ± 3 years) playing at the second and third level in the Norwegian league participated in the study. All players answered a questionnaire, including one question about hamstring strain injury (yes/no) during the previous 2 years. They also performed a 40 m maximal sprint test, a repeated sprint test (8 × 20 m), a countermovement jump, a maximal oxygen consumption (VO2max) test, strength tests and flexibility tests. Independent sample t-tests were used to evaluate differences in the physical capacity of the players who had suffered from hamstring strain injury and those who had not. Mixed between-within subject's analyses of variance was used to compare changes in speed during the repeated sprint test between groups. Results: Players who reported hamstring strain injury during the previous two years (16%) had a significantly higher drop in speed (0.07 vs. 0.02 s, p = 0.007) during the repeated sprint test, compared to players reporting no previous hamstring strain injury. In addition, there was a significant interaction (groups × time) (F = 3.22, p = 0.002), showing that speed in the two groups changed differently during the repeated sprint test. There were no significant differences in relations to age, weight, height, body fat, linear speed, countermovement jump height, leg strength, VO2max, or hamstring flexibility between the groups. Conclusion: Soccer players who reported hamstring strain injury during the previous 2 years showed significant higher drop in speed during the repeated sprint test compared to players with no hamstring

  11. Planktic foraminifer census data from Northwind Ridge cores PI-88-AP P3, PI-88-AR P7 and PI-88-AR P9, Arctic Ocean (United States)

    Foley, Kevin M.; Poore, Richard Z.


    The U.S. Geological Survey recovered 9 piston cores from the Northwind Ridge in the Canada Basin of the Arctic Ocean from a cruise of the USCGC Polar Star during 1988. Preliminary analysis of the cores suggests sediments deposited on Northwind Ridge preserve a detailed record of glacial and interglacial cycles for the last few hundred-thousand to one million years. This report includes quantitative data on foraminifers and selected sediment size-fraction data in 98 samples from Northwind Ridge core PI-88AR P3, 51 samples from core PI-88-AR P7 and 117 samples from core PI-88-AR P9.

  12. Atom trap trace analysis of {sup 39}Ar

    Energy Technology Data Exchange (ETDEWEB)

    Welte, Joachim


    Detection of {sup 39}Ar in natural water samples can be employed for radiometric dating on a timescale of 50 to 1000 years before present. This experimental work comprises the setup of an atomic beam and trap apparatus that captures and detects {sup 39}Ar atoms by the laser-cooling technique ''Atom Trap Trace Analysis''. With this approach, the limitations of low-level counting, regarding sample size and measurement time, could be overcome. In the course of this work, the hyperfine structure spectrum of the cooling transition 1s{sub 5}-2p{sub 9} has been experimentally determined. A high intensity, optically collimated beam of slow metastable argon atoms has been set up and fluorescence detection of individual {sup 39}Ar atoms in a magneto-optical trap is realized. {sup 39}Ar count rates of 1 atom in about 4 hours have been achieved for atmospheric argon. Recent improvements further suggest that even higher count rates of 1 atom/hour are within reach.

  13. The Coronae of AR Lac

    CERN Document Server

    Huenemoerder, D P; Drake, J J; Sanz-Forcada, J; Canizares, Claude R.; Drake, Jeremy J.; Huenemoerder, David P.; Sanz-Forcada, Jorge


    We observed the coronally active eclipsing binary, AR Lac, with the High Energy Transmission Grating on Chandra for a total of 97 ks, spaced over five orbits, at quadratures and conjunctions. Contemporaneous and simultaneous EUV spectra and photometry were also obtained with the Extreme Ultraviolet Explorer. Significant variability in both X-ray and EUV fluxes were observed, dominated by at least one X-ray flare and one EUV flare. We saw no evidence of primary or secondary eclipses. X-ray flux modulation was largest at high temperature, indicative of flare heating of coronal plasma. Line widths interpreted in terms of Doppler broadening suggest that both binary stellar components are active. From line fluxes obtained from total integrated spectra, we have modeled the emission measure and abundance distributions. A strong maximum was found in the differential emission measure, characterized by peaks at log T = 6.9 and 7.4, together with a weak but significant cooler maximum near log T=6.2, and a moderately str...

  14. Revised error propagation of 40Ar/39Ar data, including covariances (United States)

    Vermeesch, Pieter


    The main advantage of the 40Ar/39Ar method over conventional K-Ar dating is that it does not depend on any absolute abundance or concentration measurements, but only uses the relative ratios between five isotopes of the same element -argon- which can be measured with great precision on a noble gas mass spectrometer. The relative abundances of the argon isotopes are subject to a constant sum constraint, which imposes a covariant structure on the data: the relative amount of any of the five isotopes can always be obtained from that of the other four. Thus, the 40Ar/39Ar method is a classic example of a 'compositional data problem'. In addition to the constant sum constraint, covariances are introduced by a host of other processes, including data acquisition, blank correction, detector calibration, mass fractionation, decay correction, interference correction, atmospheric argon correction, interpolation of the irradiation parameter, and age calculation. The myriad of correlated errors arising during the data reduction are best handled by casting the 40Ar/39Ar data reduction protocol in a matrix form. The completely revised workflow presented in this paper is implemented in a new software platform, Ar-Ar_Redux, which takes raw mass spectrometer data as input and generates accurate 40Ar/39Ar ages and their (co-)variances as output. Ar-Ar_Redux accounts for all sources of analytical uncertainty, including those associated with decay constants and the air ratio. Knowing the covariance matrix of the ages removes the need to consider 'internal' and 'external' uncertainties separately when calculating (weighted) mean ages. Ar-Ar_Redux is built on the same principles as its sibling program in the U-Pb community (U-Pb_Redux), thus improving the intercomparability of the two methods with tangible benefits to the accuracy of the geologic time scale. The program can be downloaded free of charge from

  15. Improved Shock Tube Measurement of the CH4 + Ar = CH3 + H + Ar Rate Constant using UV Cavity-Enhanced Absorption Spectroscopy of CH3. (United States)

    Wang, Shengkai; Davidson, David F; Hanson, Ronald K


    We report an improved measurement for the rate constant of methane dissociation in argon (CH4 + Ar = CH3 + H + Ar) behind reflected shock waves. The experiment was conducted using a sub-parts per million sensitivity CH3 diagnostic recently developed in our laboratory based on ultraviolet cavity-enhanced absorption spectroscopy. The high sensitivity of this diagnostic allowed for measurements of quantitatively resolved CH3 time histories during the initial stage of CH4 pyrolysis, where the reaction system is clean and free from influences of secondary reactions and temperature change. This high sensitivity also allowed extension of our measurement range to much lower temperatures (shock measurements were performed at temperatures between 1487 and 1866 K and pressures near 1.7 atm, resulting in the following Arrhenius rate constant expression for the title reaction: k(1.7 atm) = 3.7 × 10(16) exp(-42 200 K/T) cm(3)/mol·s, with a 2σ uncertainty factor of 1.25. The current data are in good consensus with various theoretical and review studies, but at the low temperature end they suggest a slightly higher (up to 35%) rate constant compared to these previous results. A re-evaluation of previous and current experimental data in the falloff region was also performed, yielding updated expressions for both the low-pressure limit and the high-pressure limit rate constants and improved agreement with all existing data.

  16. Bacillus sp.CDB3 isolated from cattle dip-sites possesses two ars gene clusters

    Institute of Scientific and Technical Information of China (English)

    Somanath Bhat; Xi Luo; Zhiqiang Xu; Lixia Liu; Ren Zhang


    Contamination of soil and water by arsenic is a global problem.In Australia, the dipping of cattle in arsenic-containing solution to control cattle ticks in last centenary has left many sites heavily contaminated with arsenic and other toxicants.We had previously isolated five soil bacterial strains (CDB1-5) highly resistant to arsenic.To understand the resistance mechanism, molecular studies have been carried out.Two chromosome-encoded arsenic resistance (ars) gene clusters have been cloned from CDB3 (Bacillus sp.).They both function in Escherichia coli and cluster 1 exerts a much higher resistance to the toxic metalloid.Cluster 2 is smaller possessing four open reading frames (ORFs) arsRorf2BC, similar to that identified in Bacillus subtilis Skin element.Among the eight ORFs in cluster 1 five are analogs of common ars genes found in other bacteria, however, organized in a unique order arsRBCDA instead of arsRDABC.Three other putative genes are located directly downstream and designated as arsTIP based on the homologies of their theoretical translation sequences respectively to thioredoxin reductases, iron-sulphur cluster proteins and protein phosphatases.The latter two are novel of any known ars operons.The arsD gene from Bacillus species was cloned for the first time and the predict protein differs from the well studied E.coli ArsD by lacking two pairs of C-terrninal cysteine residues.Its functional involvement in arsenic resistance has been confirmed by a deletion experiment.There exists also an inverted repeat in the intergenic region between arsC and arsD implying some unknown transcription regulation.

  17. 40Ar/39Ar ages of lunar impact glasses: Relationships among Ar diffusivity, chemical composition, shape, and size

    CERN Document Server

    Zellner, N E B


    Lunar impact glasses, quenched melts produced during cratering events on the Moon, have the potential to provide not only compositional information about both the local and regional geology of the Moon but also information about the impact flux over time. We present in this paper the results of 73 new 40Ar/39Ar analyses of well-characterized, inclusion-free lunar impact glasses and demonstrate that size, shape, chemical composition, fraction of radiogenic 40Ar retained, and cosmic ray exposure (CRE) ages are important for 40Ar/39Ar investigations of these samples. Specifically, analyses of lunar impact glasses from the Apollo 14, 16, and 17 landing sites indicate that retention of radiogenic 40Ar is a strong function of post-formation thermal history in the lunar regolith, size, and chemical composition. Based on the relationships presented in this paper, lunar impact glasses with compositions and sizes sufficient to have retained 90% of their radiogenic Ar during 750 Ma of cosmic ray exposure at time-integra...

  18. Spatial evaluation of Ar-systematics in rocks from the British Channel Islands: a UV laserprobe Ar/Ar study of excess 40Ar (United States)

    Schwenzer, S. P.; Sherlock, S.; Kelley, S. P.


    The Ar-Ar method is a powerful tool for constraining thermal histories of metamorphic and plutonic rocks, most commonly undertaken on potassium rich mineral separates rather than whole rocks. While this approach usually yields reasonable thermal histories, it is rarely as precise as dating volcanics, and such rocks are also frequently contaminated by excess argon, artificially elevating the Ar-Ar ages. Understanding the evolution of excess argon represents a challenge; whilst it is possible to discern the ‘sink’ as the host mineral now contaminated by excess argon, examining the ‘source’ and ‘transport’ mechanism is more challenging. The approach we have taken here is to combine measurements of potassium rich and potassium poor minerals to understand the argon reservoirs and argon transfer between minerals, grain boundaries and fluids. Considering the system as a whole provides a method for understanding the complete history of the rock and thus assessing any interactions which may impact on the interpretation of ages and thermal history [Kelley, 2002, Chem. Geol. 188]. Here we have studied a series of plutonic and metamorphic basement samples from the British Channel Islands with different ages and post-emplacement histories, namely Icart Gneiss, Perelle Quartz Diorite, L’Ancresse Granodiorite, and Bordeaux Diorite. The formation age of Icart Gneiss is ~2000 Ma [D’Lemos et al., 1990, Geol. Soc. Spec. Pub. 51]. Ar-Ar ages of hornblendes and biotites from quartz diorites on Guernsey and Sark range between 606 and 596 Ma [Dallmeyer et al. 1991, J. Geol. Soc. London 148], whilst U-Pb zircon ages are in the range 710 to 613 Ma [Dallmeyer et al. 1991; Samson & D’Lemos 1998, J. Geol. Soc. London 155; Miller et al. 1999, Tectonophysics 132]. Detailed petrograpic (microscope, electron microprobe) investigations established the crystallization and deformation history of the samples, and revealed that post-magmatic alteration is unevenly distributed. This

  19. 40Ar/39Ar Ages of Carbonaceous Xenoliths in 2 HED Meteorites (United States)

    Turrin, B.; Lindsay, F. N.; Park, J.; Herzog, G. F.; Delaney, J. S.; Swisher, C. C., III; Johnson, J.; Zolensky, M.


    The generally young K/Ar and 40Ar/39Ar ages of CM chondrites made us wonder whether carbonaceous xenoliths (CMX) entombed in Howardite–Eucrite–Diogenite (HED) meteorites might retain more radiogenic 40Ar than do ‘free-range’ CM-chondrites. To find out, we selected two HED breccias with carbonaceous inclusions in order to compare the 40Ar/39Ar release patterns and ages of the inclusions with those of nearby HED material. Carbonaceous inclusions (CMXs) in two HED meteorites lost a greater fraction of radiogenic 40Ar than did surrounding host material, but a smaller fraction of it than did free-range CM-chondrites such as Murchison or more heavily altered ones. Importantly, however, the siting of the CMXs in HED matrix did not prevent the 40Ar loss of about 40 percent of the radiogenic 40Ar, even from phases that degas at high laboratory temperatures. We infer that carbonaceous asteroids with perihelia of 1 astronomical unit probably experience losses of at least this size. The usefulness of 40Ar/39Ar dating for samples returned from C-type asteroids may hinge, therefore, on identifying and analyzing separately small quantities of the most retentive phases of carbonaceous chondrites.

  20. Infrared and microwave study of angular-radial coupling effects in Ar-HCN (United States)

    Fraser, G. T.; Pine, A. S.


    Microwave and infrared spectra of Ar-HCN have been obtained using an electric-resonance optothermal spectrometer. The microwave measurements extend to higher J the previous results of Leopold et al. and Klots et al., allowing the determination of higher-order centrifugal distortion constants for this quasilinear, highly nonrigid complex. A Padé approximant fit to the microwave data indicates a significant rotation-induced asymptotic increase in the zero-point center-of-mass separation between the Ar and the HCN, above that expected from pure radial distortion. This results from the large coupling between the angular and radial degrees in the intermolecular potential forcing the centrifugal alignment of the HCN. Infrared spectra are reported for the C-H streching fundamental ν1 and the combination band ν1+ν15, where ν5 is the van der Waals bending vibration. The band-origin difference between these two bands gives ν5=7.8 cm-1, in rough agreement with the 10 cm-1 harmonic value predicted from the microwave-determined nuclear quadrupole coupling constant. The complexation-induced red shift of the C-H stretching vibration is 2.69 cm-1 and the vibrational predissociation linewidths Γ are <10 MHz (FWHM). The vibrationally excited complex predissociates before striking the bolometer detector, implying that the predissociation lifetime τ<1 ms.

  1. Noninvasive Detection of AR-FL/AR-V7 as a Predictive Biomarker for Therapeutic Resistance in Men with Metastatic Castration-Resistant Prostate Cancer (United States)


    Accomplishments 4 4. Impact 9 5. Changes /Problems 11 6. Products 12 7. Participants & Other Collaborating Organizations 15 8. Special Reporting...AWARD NUMBER: W81XWH-15-2-0052 TITLE: Noninvasive Detection of AR-FL/AR-V7 as a Predictive Biomarker for Therapeutic Resistance in Men with...Metastatic Castration- Resistant Prostate Cancer PRINCIPAL INVESTIGATOR: Stephen Plymate RECIPIENT: University of Washington Seattle, WA 98195

  2. Complete Genome Sequence of Mayaro Virus (Togaviridae, Alphavirus) Strain BeAr 20290 from Brazil. (United States)

    Espósito, Danillo Lucas Alves; da Fonseca, Benedito Antônio Lopes


    We report here the complete genome sequence of Mayaro virus strain BeAr 20290 isolated from Haemagogus mosquitoes in 1960. The sequence presented here includes all nonstructural and structural proteins and the 5'- and 3'-untranslated (UTR) regions.

  3. Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis. (United States)

    Takeshita, Yukio; Fujinaga, Ryutaro; Zhao, Changjiu; Yanai, Akie; Shinoda, Koh


    Huntingtin-associated protein 1 (HAP1), an interactor of huntingtin, has been known as an essential component of the stigmoid body (STB) and recently reported to play a protective role against neurodegeneration in Huntington's disease (HD). In the present study, subcellular association between HAP1 and androgen receptor (AR) with a long polyglutamine tract (polyQ) derived from spinal-and-bulbar-muscular-atrophy (SBMA) was examined using HEp-2 cells cotransfected with HAP1 and/or normal ARQ25, SBMA-mutant ARQ65 or deletion-mutant AR cDNAs. The results provided the first clear evidence that HAP1 interacts with AR through its ligand-binding domain in a polyQ-length-dependent manner and forms prominent inclusions sequestering polyQ-AR, and that addition of dihydrotestosterone reduces the association strength of HAP1 with ARQ25 more dramatically than that with ARQ65. Furthermore, SBMA-mutant-ARQ65-induced apoptosis was suppressed by cotransfection with HAP1. Our findings strongly suggest that HAP1/STB is relevant to polyQ-length-dependent modification on subcellular AR functions and critically involved in pathogenesis of not only HD but also SBMA as an important intrinsic neuroprotectant determining the threshold for cellular vulnerability to apoptosis. Taking together with previous reports that HAP1/STB is selectively expressed in the brain regions spared from degenerative targets in HD and SBMA, the current study might explain the region-specific occurrence of neurodegeneration in both diseases, shedding light on common aspects of their molecular pathological mechanism and yet-to-be-uncovered diagnostic or therapeutic applications for HD and SBMA patients.

  4. Higher Education Reform for Quality Higher Education Management in the 21st Century: Economic, Technological, Social, and Political Forces Affecting Higher Education. Proceedings of the 1999 Six-Nation Summit (Hiroshima, Japan, September 20-21, 1999). RIHE International Seminar Reports, No. 11. (United States)

    Hiroshima Univ. (Japan). Research Inst. for Higher Education.

    This publication presents proceedings from a 1999 conference on higher education reform and quality that involved six countries: China, Germany, Japan, Singapore, Switzerland, and the United States. The first section, "Report of the Six-Nation Higher Education Project," presents "Summary of the Progress of the Higher Education…

  5. Differential Contributions of the Complement Anaphylotoxin Receptors C5aR1 and C5aR2 to the Early Innate Immune Response against Staphylococcus aureus Infection

    Directory of Open Access Journals (Sweden)

    Sarah A. Horst


    Full Text Available The complement anaphylatoxin C5a contributes to host defense against Staphylococcus aureus. In this study, we investigated the functional role of the two known C5a receptors, C5aR1 and C5aR2, in the host response to S. aureus. We found that C5aR1−/− mice exhibited greater susceptibility to S. aureus bloodstream infection than wild type and C5aR2−/− mice, as demonstrated by the significantly higher bacterial loads in the kidneys and heart at 24 h of infection, and by the higher levels of inflammatory IL-6 in serum. Histological and immunohistochemistry investigation of infected kidneys at 24 h after bacterial inoculation revealed a discrete infiltration of neutrophils in wild type mice but already well-developed abscesses consisting of bacterial clusters surrounded by a large number of neutrophils in both C5aR1−/− and C5aR2−/− mice. Furthermore, blood neutrophils from C5aR1−/− mice were less efficient than those from wild type or C5aR2−/− mice at killing S. aureus. The requirement of C5aR1 for efficient killing of S. aureus was also demonstrated in human blood after disrupting C5a-C5aR1 signaling using specific inhibitors. These results demonstrated a role for C5aR1 in S. aureus clearance as well as a role for both C5aR1 and C5aR2 in the orchestration of the inflammatory response during infection.

  6. Young adolescents who combine alcohol and energy drinks have a higher risk of reporting negative behavioural outcomes. (United States)

    Holubcikova, Jana; Kolarcik, Peter; Madarasova Geckova, Andrea; Joppova, Eva; van Dijk, Jitse P; Reijneveld, Sijmen A


    To explore whether young adolescents consuming alcohol and energy drinks combined were more likely to report negative behavioural outcomes than their peers who drink only one type of these beverages or are abstinent. We analysed data on a representative sample of Slovak adolescents 8502 adolescents (mean age 13.21, 49.4 % boys) from the 2014 Health Behaviour in School-aged Children cross-sectional study. We assessed the associations of alcohol and energy drinks consumption with negative outcomes and their potential synergy, as measured by the synergy index (SI). Adolescents consuming both alcohol and energy drinks were at higher risk of negative behavioural outcomes than their peers who drank only alcohol or energy drinks or were non-consumers. Consumers of alcohol and energy drinks were highly prone to be involved in fighting-the joint association of alcohol and energy drinks consumption was greater than sum of its associations separately in relation to fighting (SI 1.49; 95 % confidence interval 1.03-2.16). Preventive strategies should aim at increasing awareness of negative behavioural outcomes-especially aggressive behaviour associated with alcohol and energy drinks consumption among young adolescents.

  7. 40Ar/ 39Ar mineral ages from the Oki metamorphic complex, Oki-Dogo, southwest Japan: implications for regional correlations (United States)

    Dallmeyer, R. D.; Takasu, A.


    The Oki metamorphic complex exposed in the Oki-Dogo islands consists predominantly of psammitic and pelitic gneisses with subordinate amphibolite and rare calcareous gneiss. The Oki gneisses were regionally metamorphosed to general amphibolite facies conditions, with local development of granulite facies assemblages. Peak metamorphic conditions of c. 800°C have been suggested. Hornblende concentrates from amphibolites collected within the Oki metamorphic complex record 40Ar/ 39Ar isotope correlation ages of 199-192 Ma. These are interpreted to date the post metamorphic cooling through temperatures required for intracrystalline retention of argon (c. 500°C). Muscovite concentrates record 40Ar/ 39Ar plateau ages of 167-168 Ma. These are interpreted to date post metamorphic cooling through appropriate closure temperature of muscovite (c. 400-375°C). Combined with the previously reported geochronological data, the Oki metamorphic complex appears to have experienced peak metamorphic conditions at c. 250 Ma. Subsequently, it cooled and was exhumed at the earth's surface at c. 90 Ma with cooling rate of c. 5°C/Ma. The Oki metamorphic complex records a similar prograde metamorphic event as the Hida metamorphic complex exposed in central Japan. The cooling and exhumation rates of the Hida metamorphic complex were significantly more rapid compared with the Oki metamorphic complex, and they were exhumed with extensively intruded Jurassic granites (Funatsu granites).

  8. arXiv in the classical Russian literature

    CERN Document Server

    Silagadze, Z K


    The creation of arXiv, a highly democratic open access repository of research papers in high-energy physics more than twenty years ago was undoubtedly the most spectacular and landmark event for the high-energy physics community. However, we report a curious observation which indicates that the general cultural significance of this event extends far beyond the boundaries assumed at the beginning.

  9. Precision angle-resolved autoionization resonances in Ar and Ne

    Energy Technology Data Exchange (ETDEWEB)

    Berrah, N.; Langer, B.; Gorczyca, T.W. [Western Michigan Univ., Kalamazoo, MI (United States)] [and others


    Theoretical work has shown that the electron angular distribution and the shape of the autoionization resonances are crucial to the understanding of certain types of electron-electron correlation. Autoionization resonances in Ne (Ar) result from the decay of the excited discrete state Ne{sup *} 2s2p{sup 6} np (Ar{sup *} 3s3p{sup 6} np) into the continuum state Ne{sup +} 2s{sup 2}2p{sup 5} + e{sup {minus}} (ks,kd) (Ar{sup +} 3s{sup 2}3p{sup 5} + e{sup {minus}} (ks,kd)). Since the continuum can also be reached by direct photoionization, both paths add coherently, giving rise to interferences that produce the characteristic Beutler-Fano line shape. In this work, the authors report on quantitative angle-resolved electron spectrometry studies of (a) the Ne 2s{sup 2}2p{sup 6} {r_arrow} 2s2p{sup 6} np (n=3-5) autoionizing resonances and the 2s{sup 2}2p{sup 6} {r_arrow} 2p{sup 4}3s3p doubly excited resonance, (b) the Ar 3s{sup 2}3p{sup 6} {r_arrow} 3s3p{sup 6} np (n=4-9) autoionization resonances and extended R-matrix calculations of the angular-distribution parameters for both Ne and Ar measurements. Their results are compared with previous theoretical work by Taylor.

  10. Discovery of underground argon with low level of radioactive 39Ar and possible applications to WIMP dark matter detectors

    CERN Document Server

    Galbiati, C


    We report on the first measurement of 39Ar in argon from underground natural gas reservoirs. The gas stored in the US National Helium Reserve was found to contain a low level of 39Ar. The ratio of 39Ar to stable argon was found to be <=4x10-17 (84% C.L.), less than 5% the value in atmospheric argon (39Ar/Ar=8x10-16). The total quantity of argon currently stored in the National Helium Reserve is estimated at 1000 tons. 39Ar represents one of the most important backgrounds in argon detectors for WIMP dark matter searches. The findings reported demonstrate the possibility of constructing large multi-ton argon detectors with low radioactivity suitable for WIMP dark matter searches.

  11. Further support for a Cretaceous age for the feathered-dinosaur beds of Liaoning,China:New 40Ar/39Ar dating of the Yixian and Tuchengzi Formations

    Institute of Scientific and Technical Information of China (English)


    We report new 40Ar/39Ar dating results obtained from total fusion and incremental-heating analyses of sanidine and biotite from three tuffs found interbedded within the fossil-bearing deposits of Liaoning, northeast China. The first is a new sample of the Bed 6 Sihetun tuff from the Yixian Formation, previously dated by our team as middle Early Cretaceous, and recently considered by Lo et al., partially reset due to metamorphism from a nearby basaltic sill. The second is the Yixian Bed 9 tuff from Hengdaozi considered by Lo et al. to be unaffected by metamorphism and whose age, based on total fusion 40Ar/39Ar dating of biotite, argues for a Jurassic age for the Yixian Formation.The third tuff is a previously undated tuff from the upper part of the underlying Tuchengzi Formation. Single crystal total fusion 40Ar/39Ar analyses of the Sihetun sanidine showed homogeneous radiogenic Ar, Ca/K ratios, excellent reproducibility and gave a mean age of 125.0 ± 0.18 (1SD) ±0.04 (SE) Ma. Single sanidine crystal total fusion 40Ar/39Aranalyses of the Hengdaozi tuff gave a mean age of 125.0 +0.19 (1SD) ± 0.04 (SE) Ma, which is indistinguishable from the Sihetun tuff. The Tuchengzi Formation tuff gave a mean age of 139.4 ± 0.19 (1SD) ± 0.05 (SE) Ma. Detailed laser incremental-heating analyses of biotite from Sihetun, Hengdaozi, and Tuchengzi tuffs show disturbed Ar release patterns and evidence of trapped argon components. We conclude from these analyses that the total fusion dates on biotite by Lo et al. are erroneously old and isotopic dating of both biotite and sanidine from tuffs of the Yixian Formation point to a middle Early Cretaceous age. The upper part of the Tuchengzi Formation can be referred to the Early Cretaceous.``

  12. Instrumentation development for In Situ 40Ar/39Ar planetary geochronology (United States)

    Morgan, Leah; Munk, Madicken; Davidheiser-Kroll, Brett; Warner, Nicholas H.; Gupta, Sanjeev; Slaybaugh, Rachel; Harkness, Patrick; Mark, Darren


    The chronology of the Solar System, particularly the timing of formation of extra-terrestrial bodies and their features, is an outstanding problem in planetary science. Although various chronological methods for in situ geochronology have been proposed (e.g., Rb-Sr, K-Ar), and even applied (K-Ar), the reliability, accuracy, and applicability of the 40Ar/39Ar method makes it by far the most desirable chronometer for dating extra-terrestrial bodies. The method however relies on the neutron irradiation of samples, and thus a neutron source. Herein, we discuss the challenges and feasibility of deploying a passive neutron source to planetary surfaces for the in situ application of the 40Ar/39Ar chronometer. Requirements in generating and shielding neutrons, as well as analysing samples are described, along with an exploration of limitations such as mass, power and cost. Two potential solutions for the in situ extra-terrestrial deployment of the 40Ar/39Ar method are presented. Although this represents a challenging task, developing the technology to apply the 40Ar/39Ar method on planetary surfaces would represent a major advance towards constraining the timescale of solar system formation and evolution.

  13. Ars Baltica-verkoston puheenjohtajuus Suomeen Risto Ruohoselle

    Index Scriptorium Estoniae


    1990. a. loodud võrgustiku Ars Baltica sekretariaat (Ars Baltica Contact Point & Communication Center) tuleb Kielist Tallinnasse Eesti kultuuriministeeriumi kuni aastani 2002 (Suur-Karja 23). Ars Baltica (ühendus)

  14. Ars Baltica-verkoston puheenjohtajuus Suomeen Risto Ruohoselle

    Index Scriptorium Estoniae


    1990. a. loodud võrgustiku Ars Baltica sekretariaat (Ars Baltica Contact Point & Communication Center) tuleb Kielist Tallinnasse Eesti kultuuriministeeriumi kuni aastani 2002 (Suur-Karja 23). Ars Baltica (ühendus)

  15. Evolution of the Ar isotopic chain: the N=28 shell gap south of {sup 48}Ca

    Energy Technology Data Exchange (ETDEWEB)

    Mengoni, D., E-mail: [Dipartimento di Fisica dell' Universita and INFN Sezione di Padova, Padova (Italy); Valiente-Dobon, J.J. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro (Italy); Gadea, A. [Instituto de Fisica Corpuscular, CSIC-Universidad de Valencia (Spain); Lenzi, S.M.; Lunardi, S. [Dipartimento di Fisica dell' Universita and INFN Sezione di Padova, Padova (Italy); Broda, R. [Institute of Nuclear Physics, Polish Academy of Sciences, Cracow (Poland); Dewald, A.; Pissulla, T. [Institut fuer Kernphysik der Universtaet zu Koeln, Koeln (Germany); Angus, L. [School of Engineering and Science, University of Paisley, Paisley, Scotland (United Kingdom); Aydin, S.; Bazzacco, D. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Padova (Italy); Benzoni, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Milano, Milano (Italy); Bizzeti, P.G.; Bizzeti-Sona, A.M. [Dipartimento di Fisica dell' Universita and INFN Sezione di Firenze, Firenze (Italy); Corradi, L. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro (Italy); Crespi, F. [Istituto Nazionale di Fisica Nucleare, Sezione di Milano, Milano (Italy); Angelis, G. de [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro (Italy); Farnea, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Padova (Italy); Fioretto, E. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro (Italy); Goergen, A. [CEA Saclay, Daphnia/SphN, Gif-sur-Yvette Cedex (France)


    The lifetimes of the first excited states of the Z = 18 {sup 44}Ar and {sup 46}Ar isotopes have been determined using a novel technique that combines the Recoil Distance Doppler Shift method with the CLARA-PRISMA spectrometers for Multinucleon Transfer Reactions. The B(E2) values extracted for the 2{sup +}->0{sup +} transitions in both nuclei, as well as for higher excites states in {sup 44}Ar, are discussed and compared with the available experimental results and with the new large-scale shell-model calculations.

  16. Ars ornata / Kadri Mälk

    Index Scriptorium Estoniae

    Mälk, Kadri, 1958-


    V rahvusvaheline ehtekunsti konverents 'Ars ornata Europeana' juuni lõpus Stockholmis. New Yorgis elava kuraatori Charon Kranseni ja prantsuse ehtekunstniku Christophe Burger' juhitud vestlusringidest. 1997. a. Pariisis loodud International Craft Design Association'ist (ICDA).

  17. "Ars Ornata" Mediterrania / Kadri Mälk

    Index Scriptorium Estoniae

    Mälk, Kadri, 1958-


    VI rahvusvaheline ehtekunstinäitus "Ars Ornata" juuni lõpus Barcelonas. Konverentsist, peanäitusest (osalejad Eestist), ehtekunstiõpetust andvast kõrgkoolist Escola Massana'st Barcelonas, õppejõude. Eesti ehtekunsti tulevikust.

  18. ARS 01 Helsingi Kiasmas / Tarmo Virki

    Index Scriptorium Estoniae

    Virki, Tarmo


    Helsingis Kiasmas avatud rahvusvahelisest kunstinäitusest ARS 01 alapealkirjaga "Avanevaid perspektiive", kus esines oma töödega ka Marko Mäetamm. Näituse raames toimuvast Santiago Sierra kunstiprojektist kodututega

  19. ARS 01 Helsingi Kiasmas / Tarmo Virki

    Index Scriptorium Estoniae

    Virki, Tarmo


    Helsingis Kiasmas avatud rahvusvahelisest kunstinäitusest ARS 01 alapealkirjaga "Avanevaid perspektiive", kus esines oma töödega ka Marko Mäetamm. Näituse raames toimuvast Santiago Sierra kunstiprojektist kodututega

  20. Ars ornata / Kadri Mälk

    Index Scriptorium Estoniae

    Mälk, Kadri, 1958-


    V rahvusvaheline ehtekunsti konverents 'Ars ornata Europeana' juuni lõpus Stockholmis. New Yorgis elava kuraatori Charon Kranseni ja prantsuse ehtekunstniku Christophe Burger' juhitud vestlusringidest. 1997. a. Pariisis loodud International Craft Design Association'ist (ICDA).

  1. Detrital mica 40Ar/39Ar dating approach for provenance and exhumation of the Eastern Alps. (United States)

    Gemignani, Lorenzo; Sun, Xilin; Van Gerve, Thomas; Braun, Jean; Wijbrans, Jan Robert


    The use of thermochronological techniques on detrital minerals, such as (U-Th)/He on apatite and zircon, zircon fission-tracks and Ar-dating on mica and microcline, can be used to constrain the lateral variation of the exhumation rate and the sediment provenance of large sectors of an actively deforming mountain belt. Analysis of modern river sands yields an inventory of ages of rocks currently cropping out and eroding in the hinterland of a river drainage basin. So far, only few studies have focused on testing the consistency of the detrital mineral age distributions and the surface bed-rock thermochronology. We present here new detrital 40Ar/39Ar biotite and muscovite age distributions for nineteen modern river sands from rivers draining the Eastern Alps north of the Periadriatic line. The ages, interpreted to reflect cooling of the source rock under the closure temperature of muscovite and biotite respectively, were compared with the in-situ ages for the bedrock in the hinterland from literature. The results were generally comparable with the bedrocks ages for both the target minerals and represent three main clusters of ages that record the main exhumation pulses in this sector of the Alps. We have applied two numerical methods to the cooling ages to a) quantify the rates of exhumation of the Tauern Window during Paleocene-Miocene period of the Alpine orogeny, b) linearly compute the spatial variability of the present-day exhumation rates of a set of 4 detrital mineral sample drainage basins along the Inn river stream. Our results suggest a 0.17-0.52 mm/yr range in exhumation rates for the Tauern Window since the Miocene. The results from modelling constrained the downstream evolution of the detrital signal in the Inn river and realistically predicts higher erosion rates in the downstream basin where young cooling ages from the Penninic units of the Tauern are drained into the system, forming a characteristic peak. Our data define more inclusive trends in

  2. Biogeochemical cyclic activity of bacterial arsB in arsenic-contaminated mines

    Institute of Scientific and Technical Information of China (English)

    CHANG Jin-Soo; PEN Xianghao; KIM Kyoung-Woong


    Biogeochemical cyclic activity of the ars (arsenic resistance system) operon is arsB influx/efflux encoded by the ecological of Pseudomonas putida. This suggests that studying arsenite-oxidizing bacteria may lead to a better understanding of molecular geomicrobiology, which can be applied to the bioremediation of arsenic-contaminated mines. This is the first report in which multiple arsB-binding mechanisms have been used on indigenous bacteria. In ArsB (swains OS-5; ABB83931; OS-19; ABB04282 and RW-28;ABB88574), there are ten putative enzyme, Histidine (His) 131, His 133, His 137, Arginine (Arg) 135, Arg 137, Arg 161, Trptohan (Trp) 142, Trp 164, Trp 166, and Trp 171, which are each located in different regions of the partial sequence. The adenosine triphosphate (ATP)-binding cassette transports, binding affinities and associating ratable constants show that As-binding is comparatively insensitive to the location of the residues within the moderately stable a-helical structure. The α-helical structures in ArsB-permease and anion permease arsB have been shown to import/export arsenic in P. putida. We proposed that arsB residues, His 131, His 133, His 137, Arg 135, Arg 137, Arg 161, Trp 142, Trp 164, Trp 166, and Trp 171 are required for arsenic binding and activation ofarsA/arsB or arsAB.This arsB influx/efflux pum-ping is important, and the effect in arsenic species change and mobility in mine soil has got a significantly ecological role because it allows arsenic oxidizing/reducing bacteria to control biogeochemical cycle of abandoned mines.

  3. 40Ar/39Ar ages of the AD 79 eruption of Vesuvius, Italy (United States)

    Lanphere, Marvin; Champion, Duane; Melluso, Leone; Morra, Vincenzo; Perrotta, Annamaria; Scarpati, Claudio; Tedesco, Dario; Calvert, Andrew


    The Italian volcano, Vesuvius, erupted explosively in AD 79. Sanidine from pumice collected at Casti Amanti in Pompeii and Villa Poppea in Oplontis yielded a weighted-mean 40Ar/39Ar age of 1925±66 years in 2004 (1σ uncertainty) from incremental-heating experiments of eight aliquants of sanidine. This is the calendar age of the eruption. Our results together with the work of Renne et al. (1997) and Renne and Min (1998) demonstrate the validity of the 40Ar/39Ar method to reconstruct the recent eruptive history of young, active volcanoes.

  4. Dating samples of lunar soil from the Mare Crisium by the Ar/39/-Ar/40/ technique (United States)

    Shanin, L. L.; Arakeliants, M. M.; Bogatikov, O. A.; Ivanenko, V. V.; Pupyrev, Iu. G.; Tarasov, L. S.; Frikh-Khar, D. I.


    Two samples (dolerite and gabbro fragments) from a depth of 184 cm in the Luna 24 core are dated using the Ar(39)-Ar(40) technique. The values obtained are found to be lower than all published isotopic ages for the Luna 24 samples. An analysis of possible dating errors of the lunar samples, together with the good agreement of the results from the Ar(39)-Ar(40) technique of geochronologic standards and anorthosite from the Korosten pluton with the results from Rb-Sr, U-Pb, and Sm-Nd methods, attests the reliability of the values.

  5. A Study of the Residual 39Ar Content in Argon from Underground Sources

    CERN Document Server

    Xu, J; Galbiati, C; Goretti, A; Guray, G; Hohman, T; Holtz, D; Ianni, A; Laubenstein, M; Loer, B; Love, C; Martoff, C J; Montanari, D; Mukhopadhyay, S; Nelson, A; Rountree, S D; Vogelaar, R B; Wright, A


    The discovery of argon from underground sources with significantly less 39Ar than atmospheric argon was an important step in the development of direct-detection dark matter experiments using argon as the active target. We report on the design and operation of a low background detector with a single phase liquid argon target that was built to study the 39Ar content of the underground argon. Underground argon from the Kinder Morgan CO2 plant in Cortez, Colorado was determined to have less than 0.65% of the 39Ar activity in atmospheric argon.

  6. Rotational energy transfer in collisions between CO and Ar at temperatures from 293 to 30 K (United States)

    Mertens, Laura A.; Labiad, Hamza; Denis-Alpizar, Otoniel; Fournier, Martin; Carty, David; Le Picard, Sébastien D.; Stoecklin, Thierry; Sims, Ian R.


    Experimental measurements and theoretical calculations are reported for rotational energy transfer in the Ar-CO system. Experiments were performed in cold uniform supersonic flows of Ar, using an infrared - vacuum ultraviolet double resonance technique to measure absolute state-to-state rate constants and total relaxation cross sections for rotational energy transfer within the (v = 2) vibrational state of CO in collision with Ar at temperatures from 30.5 to 293 K. Close-coupling calculations were also performed using a recent potential energy surface (Sumiyoshi and Endo, 2015). Very good agreement is obtained between measured and calculated values.

  7. /sup 40/Ar-/sup 39/Ar dating of melt rock from impact craters

    Energy Technology Data Exchange (ETDEWEB)

    Bottomley, R.J.


    Meteorite impacts produce large volumes of shocked and brecciated rocks near the impact site. If the impact is large enough, target rocks will be fused to form melt rock which often pools on the crater floor. This melt rock will typically have a fine grained matrix enclosing heated but unmelted clasts of broken country rock. A suite of melt rocks from fifteen craters along with shocked rock from one crater and three tektites were analyzed by 40Ar-39Ar dating to study the argon systematics of melted and shocked rocks and to determine the time of impact which formed the craters. The age spectra from most of the melt rock samples turned out to be more complex than expected. The spectra could be classified into four families: 1) good plateaux; 2) structured plateaux; 3) stepwise rising spectra; and 4) snail shape spectra. In most cases an age based on one or both of these factors could be made of the non-plateau spectra. However the meaning of the resulting age is less certain than in the good plateaux cases. On the basis of their age, either of two Canadian craters, Wanapitei or Mistastin, could be comtemporaneous with the formation of the bediasites, raising the possibility that more than one impact was responsible for North American tektite strewnfield. In addition, there appears to be evidence that there was a higher than average incidence of impacts about 35 m.y. ago. During sample fusion, melt rocks release a greater proportion of their argon below 800/sup 0/C than do most terrestrial whole rocks.

  8. Allergic rhinitis and co-morbid asthma: perspective from India -- ARIA Asia-Pacific Workshop report. (United States)

    Shah, Ashok; Pawankar, Ruby


    In India, allergic rhinitis (AR) is considered to be a trivial disease, despite the fact that symptoms of rhinitis were present in 75% of children and 80% of asthmatic adults. Traditionally, AR was also divided into seasonal or perennial, based on the time of occurrence of symptoms during the year. The ARIA workshop report proposed that patients be categorized as "intermittent" and "persistent" while severity was classified as "mild" and "moderate-severe". Patients with AR, depending on their predominant symptom, can also be categorized as "sneezers-runners" and "blockers". On sketching their clinical profile, it was observed that "blockers" had significantly higher sinusitis and had higher sensitization to fungi. Skin allergy testing in Indian adults showed that in patients with AR house dust mite (Dermatophagoides farinae) was the most common allergen. Studies conducted in India have shown that AR often restricts the patient's quality of life (QOL). It can affect the physical, psychological and social aspects of the patients' life and can also impact their functions at work. Furthermore, AR adversely affects sleep related QOL. Topical corticosteroids are now considered as the cornerstone of the treatment for AR. In spite of causing a major impact on the QOL in Indian patients, AR is rarely given the importance it deserves.

  9. Ar-Ar Analysis of Chelyabinsk: Evidence for a Recent Impact (United States)

    Beard, S. P.; Kring, D. A.; Isachsen, C. E.; Lapen, T. J.; Zolensky, M. E.; Swindle, T. D.


    The Chelyabinsk meteorite is an LL5 ordinary chondrite that fell as a spectacular fireball on February 15th, 2013, over the Ural region in Russia. The meteoroid exploded at an altitude of 25-30 km, producing shockwaves that broke windowpanes in Chelyabinsk and surrounding areas, injuring some 1500 people. Analyses of the samples show that the meteorite underwent moderate shock metamorphism (stage S4; 25-35 GPa) [1]. Most of the samples have a fusion crust ranging from 0.1-1mm thick, and roughly a third of the samples were composed of a dark fine-grained impact melt with chondrule fragments which were targeted for chronometry. A Pb-Pb age obtained by [2] of a shock-darkened and potentially melted sample of Chelyabinsk is reported as 4538.3 +/- 2.1 Ma, while a U-Pb study [3] gave an upper concordia intercept of 4454 +/- 67 Ma and a lower intercept of 585 +/- 390. Galimov et al. 2013 [1] suggest the Sm-Nd system records a recent impact event [290 Ma] that may represent separation from the parent body, while the Rb-Sr isotopic system is disturbed and does not give any definitive isochron. In order to better understand its history, we have performed 40Ar-39Ar analysis on multiple splits of two Chelyabinsk samples; clast- rich MB020f,2 and melt-rich MB020f,5. The term "clast-rich" lithology is meant to indicate a mechanical mixture of highly shock-darkened and less shocked components, both with some shock melt veining.

  10. Mound Facility activities in chemical and physical research: July--December 1977. [Kr-Xe and Kr-Ar diffusion; Ne-Ar thermal diffusion

    Energy Technology Data Exchange (ETDEWEB)


    Isotope separation of Ar, C, /sup 3/He, Kr, Ne, O, and Xe isotopes is reported. TiFeH/sub x/, TiCoH/sub x/, TiCuH/sub x/, and VH/sub x/ were studied using NMR (proton relaxation times). VD/sub x/ and VT/sub x/ were synthesized. The problem of calculating the valence state of Pu is discussed. A series solution to the plutonium (N,H) characteristic equation is suggested. Shipments of /sup 231/Pa, /sup 230/Th, and /sup 229/Th are reported. Separation and processing of /sup 234/U are also reported. Theoretical methods were developed to calculate temperature distributions as functions of water flow rate in liquid thermal diffusion columns. Diffusion coefficients were measured from 300 to 1200/sup 0/K for Kr-Xe and Kr-Ar. New thermal diffusion factors are submitted for Ne-Ar.

  11. 40Ar/ 39Ar systematics and argon diffusion in amber: implications for ancient earth atmospheres (United States)

    Landis, G. P.; Snee, L. W.


    Argon isotope data indicate retained argon in bulk amber (matrix gas) is radiogenic [ 40Ar/ 39Ar ≃32o] than the much more abundant surface absorbed argon [ 40Ar/ 39Ar ≃295.5]. Neutron-induced 39Ar is retained in amber during heating experiments to 150° -250°C, with no evidence of recoiled 39Ar found after irradiation. A maximum permissible volume diffusion coefficient of argon in amber (at ambient temperature) D≤1.5 x 10 -17 cm 2S -1 is calculated from 39Ar retention. 40Ar/ 39Ar age calculations indicate Dominican Republic amber is ≃ 45 Ma and North Dakota amber is ≃ 89 Ma, both at least reasonable ages for the amber based upon stratigraphic and paleontological constraints and upon the small amount of radiogenic 40Ar. To date, over 300 gas analyses of ambers and resins of Cretaceous to Recent age that are geographically distributed among fifteen noted world locations identify mixtures of gases in different sites within amber (Berner and Landis, 1988). The presence of multiple mixing trends between compositionally distinct end-members gases within the same sample and evidence for retained radiogenic argon within the amber argue persuasivley against rapid exchange by diffusion of amber-contained gases with moder air. Only gas in primary bubbles entrapped between successive flows of tree resin has been interpreted as original "ancient air", which is an O 2-rich end-member gas with air-like N 2/Ar ratios. Gas analyses of these primary bubbles indicate atmospheric O 2 levels in the Late Cretaceous of ≃ 35%, and that atmospheric O 2 dropped by early Tertiary time to near a present atmospheric level of 21% O 2. A very low argon diffusion coefficient in amber persuasively argues for a gas in primary bubbles trapped in amber being ancient air (possibly modified only by O 2 reaction with amber).

  12. The University of North Carolina Report on Expanding Access to Higher Education through State-Funded Distance Education Programs (United States)

    University of North Carolina General Administration, 2012


    Legislation in 1998 provided enrollment funding for UNC distance education. This report documents the growth of UNC distance education programs and their role in meeting the high priority education and economic development needs of the State. As highlighted in the Executive Summary and documented throughout this report, state enrollment funding…

  13. ArsP: a methylarsenite efflux permease. (United States)

    Chen, Jian; Madegowda, Mahendra; Bhattacharjee, Hiranmoy; Rosen, Barry P


    Trivalent organoarsenic compounds are far more toxic than either pentavalent organoarsenicals or inorganic arsenite. Many microbes methylate inorganic arsenite (As(III)) to more toxic and carcinogenic methylarsenite (MAs(III)). Additionally, monosodium methylarsenate (MSMA or MAs(V)) has been used widely as an herbicide and is reduced by microbial communities to MAs(III). Roxarsone (3-nitro-4-hydroxybenzenearsonic acid) is a pentavalent aromatic arsenical that is used as antimicrobial growth promoter for poultry and swine, and its active form is the trivalent species Rox(III). A bacterial permease, ArsP, from Campylobacter jejuni, was recently shown to confer resistance to roxarsone. In this study, C. jejuni arsP was expressed in Escherichia coli and shown to confer resistance to MAs(III) and Rox(III) but not to inorganic As(III) or pentavalent organoarsenicals. Cells of E. coli expressing arsP did not accumulate trivalent organoarsenicals. Everted membrane vesicles from those cells accumulated MAs(III) > Rox(III) with energy supplied by NADH oxidation, reflecting efflux from cells. The vesicles did not transport As(III), MAs(V) or pentavalent roxarsone. Mutation or modification of the two conserved cysteine residues resulted in loss of transport activity, suggesting that they play a role in ArsP function. Thus, ArsP is the first identified efflux system specific for trivalent organoarsenicals.

  14. Evaluation of sintering effects on SiC-incorporated UO2 kernels under Ar and Ar-4%H2 environments (United States)

    Silva, Chinthaka M.; Lindemer, Terrence B.; Hunt, Rodney D.; Collins, Jack L.; Terrani, Kurt A.; Snead, Lance L.


    Silicon carbide (SiC) is suggested as an oxygen getter in UO2 kernels used for tristructural isotropic (TRISO) particle fuels and to prevent kernel migration during irradiation. Scanning electron microscopy and X-ray diffractometry analyses performed on sintered kernels verified that an internal gelation process can be used to incorporate SiC in UO2 fuel kernels. Even though the presence of UC in either argon (Ar) or Ar-4%H2 sintered samples suggested a lowering of the SiC up to 3.5-1.4 mol%, respectively, the presence of other silicon-related chemical phases indicates the preservation of silicon in the kernels during sintering process. UC formation was presumed to occur by two reactions. The first was by the reaction of SiC with its protective SiO2 oxide layer on SiC grains to produce volatile SiO and free carbon that subsequently reacted with UO2 to form UC. The second process was direct UO2 reaction with SiC grains to form SiO, CO, and UC. A slightly higher density and UC content were observed in the sample sintered in Ar-4%H2, but both atmospheres produced kernels with ˜95% of theoretical density. It is suggested that incorporating CO in the sintering gas could prevent UC formation and preserve the initial SiC content.

  15. Pneumatically sprayed Cu2ZnSnS4 films under Ar and Ar-H2 atmosphere (United States)

    Espindola Rodriguez, M.; Sylla, D.; Sanchez, Y.; López-Marino, S.; Fontané, X.; López-García, J.; Placidi, M.; Pérez-Rodríguez, A.; Vigil-Galán, O.; Saucedo, E.


    Cu2ZnSnS4 (CZTS) thin films have been deposited by pneumatic spray pyrolysis onto soda-lime glass and Mo-coated glass substrates by using a special reactor designed for working under controlled atmospheres. The films were grown using both Ar and Ar-H2 as the carrier gas and atmosphere, aiming to eliminate the oxygen-containing atmosphere from the classical spray pyrolysis configuration that uses air as the carrier gas. Thin films with different compositions were prepared and thermally annealed to investigate its compositional and physical properties and its performance as absorber layers in solar cells. To know the impact of the thermal annealing, two different annealing temperatures were used: 550 and 580 °C, both for 30 min. The last temperature showed a great improvement in the crystallinity and allowed a better incorporation of Sn into the films. The optical band gap of the annealed films was found to be around 1.45 eV. Cu-S and ZnO were found as contaminant phases in the as-grown Ar-sprayed samples, but were effectively transformed after annealing. ZnS was detected in both the as-grown and annealed films as the main secondary phase. Solar cells free of scarce elements were fabricated showing an improved conversion efficiency of 1.4%, evidencing the higher potential of this approach for the synthesis of device-grade films.

  16. Television for Higher Technical Education of Workers. Final Report On a Pilot Project in Poland. Reports and Papers on Mass Communication Number 67. (United States)

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). Dept. of Mass Communication.

    The "Television Polytechnic" program of 1966 - 1970 was a joint effort of the Polish Ministry of Higher Education and Polish Television to provide televised education for working students. The subjects taught were those normally included in the first two years of the higher technical schools--math, physics, geometry, chemistry, mechanics…

  17. Degradation Assessment and Fault Diagnosis for Roller Bearing Based on AR Model and Fuzzy Cluster Analysis

    Directory of Open Access Journals (Sweden)

    Lingli Jiang


    Full Text Available This paper proposes a new approach combining autoregressive (AR model and fuzzy cluster analysis for bearing fault diagnosis and degradation assessment. AR model is an effective approach to extract the fault feature, and is generally applied to stationary signals. However, the fault vibration signals of a roller bearing are non-stationary and non-Gaussian. Aiming at this problem, the set of parameters of the AR model is estimated based on higher-order cumulants. Consequently, the AR parameters are taken as the feature vectors, and fuzzy cluster analysis is applied to perform classification and pattern recognition. Experiments analysis results show that the proposed method can be used to identify various types and severities of fault bearings. This study is significant for non-stationary and non-Gaussian signal analysis, fault diagnosis and degradation assessment.

  18. Modeling Augmented Reality User Interfaces with SSIML/AR

    Directory of Open Access Journals (Sweden)

    Arnd Vitzthum


    Full Text Available Augmented Reality (AR technologies open up new possibilities especially for task-focused domains such as assembly and maintenance. However, it can be noticed that there is still a lack of concepts and tools for a structured AR development process and an application specification above the code level. To address this problem we introduce SSIML/AR, a visual modeling language for the abstract specification of AR applications in general and AR user interfaces in particular. With SSIML/AR, three different aspects of AR user interfaces can be described: The user interface structure, the presentation of relevant information depending on the user’s current task and the integration of the user interface with other system components. Code skeletons can be generated automatically from SSIML/AR models. This enables the seamless transition from the design level to the implementation level. In addition, we sketch how SSIML/AR models can be integrated in an overall AR development process.

  19. Efficiency and Effectiveness in Higher Education: A Report by the Universities UK Efficiency and Modernisation Task Group (United States)

    Universities UK, 2011


    Effectiveness, efficiency and value for money are central concerns for the higher education sector. In England, decisions made by the current Government will effect a radical change in the funding for teaching. Institutions will be managing a reduction in public funding for teaching and the transition to the new system of graduate contributions,…

  20. Considering Teaching Excellence in Higher Education: 2007-2013. A Literature Review since the CHERI Report 2007. HEA Research Series (United States)

    Gunn, Vicky; Fisk, Anna


    This research review explores both the research and the grey literature on university teaching excellence with a specific remit to update an earlier review, "Excellence in Teaching and Learning: a review of literature for the Higher Education Academy". Little, B., et al (2007) The two main aims are: (1) to suggest further areas of…

  1. Production of Doctorates in the Biosciences, 1975-1980: An Experimental Forecast. Higher Education Panel Reports, No. 34. (United States)

    Atelsek, Frank J.; Gomberg, Irene L.

    A survey was undertaken in 1976 to obtain short-term estimates of doctorate production directly from the heads of the science departments involved. These biosciences departments were surveyed in the 235 member institutions of the Higher Education Panel that grant doctorates: anatomy, biochemistry, biology, biometry/biostatistics/biomathematics,…

  2. Adult, Continuing, and In-Service Education and the Library in Higher Education: A Bibliographic Check List. Report No. 11. (United States)

    Stevens, Nicholas G.

    As an aid for educational change, a bibliography has been prepared in the areas of: trends and developments in higher education; science, technology, civilization, and social change; the future and future research; the library-college concept; the articulation program; educational coordination; interinstitutional cooperation; transfer students;…

  3. Progreso y retos de la geocronología 40Ar/39Ar en Costa Rica y Nicaragua Progress and Challenges Using 40Ar/39Ar Geochronology in Costa Rica and Nicaragua

    Directory of Open Access Journals (Sweden)

    Ian Saginor¹


    Full Text Available Con el principal objetivo de realizar mejores cálculos de la producción volcánica, en el Arco Volcánico de América Central, realizamos 61 dataciones 40Ar/39Ar en tefras y lavas en localidades de frente volcánico de Costa Rica y Nicaragua por medio de varias campañas de campo y análisis de laboratorio (preparación de muestras, envió al reactor nuclear, espectroscopía de masas de las muestras radiactivas, al laboratorio de gases nobles del Departamento de Ciencias de la Tierra y Planetarias de la Universidad Rutgers del 2002-2008. En este artículo presentamos diferentes observaciones que resultaron de este estudio donde se describe la precisión, exactitud y la confiabilidad de las edades 40Ar/39Ar. El primer resultado muestra las limitaciones de esta técnica en muestras baja en K2O con edades To better estimate the extrusive flux of the Central American Arc, from 2002-2008, we obtained sixty one high precision 40Ar/39Ar ages on geographically well-situated lavas and tephra from Costa Rica and Nicaragua. Here, we describe a number of observations encountered during this study using four examples that well document the precision, accuracy and general reliability of the 40Ar/39Ar ages. First, low K2O values, particularly in samples from Nicaragua, is a major limitation in or attempts to obtain reliable dates on samples under 1 My. Second, extensive weathering of samples due to the tropical climate of Central America has resulted in various levels of argon loss even when the hand sample appeared unaltered. Third, our field and geochronological data lead us to conclude that eruptive rates have not been constant over the past 15 to 20 My, but rather appears punctuated by gaps of up to several million years. We attempted to address the temporal gaps in several ways. First, geochemical analyses were used to identify samples that may have erupted during time periods without known volcanism. For example, U/Th values in the active Central

  4. AR-扩增实境

    Institute of Scientific and Technical Information of China (English)


    1、什么是AR-扩增实境?AR-扩增实境(Augmented Reality,简称AR),简单地说,就是把虚拟的物体和现实的场景进行嫁接。这是一种实时地计算摄影机影像的位置及角度并加上相应图像的技术,这种技术的目标是在屏幕上把虚拟世界套在现实世界并进行互动。

  5. 40Ar/39Ar and K/Ar dating of low grade metamorphism: examples on metabasites from Central Chile (United States)

    Aguirre, L.; Feraud, G.; Fuentes, F.; Delbar, M.; Morata, D.


    Dating low to very low-grade burial metamorphic assemblages is often difficult because of (1) few mineral phases compositionally suitable to apply the 40Ar/39Ar and K-Ar methods, and (2) small amount in which these phases are commonly found. K-feldspar adularia, sericitic mica, and celadonite are the best known K-bearing secondary minerals. We present some successful attempts to analyse two distinct secondary phases from a same volcanic formation that allow to test the validity of the measured ages. These ages have been also compared with the crystallisation age of the volcanic rocks in which the secondary phases were lately developed. Adularia and sericite were selected from basic lava flows from a 3 to 13 km thick Cretaceous sequence from the Coastal Range of central Chile, at two different locations: the Bustamante Hill (west from Santiago), and the Cordón de Chacana, c. 80 km further north. Adularia came from a low-variance assemblage with pumpellyite, chlorite and low-albite contained in amygdules whereas sericite was present in milky-white strongly sericitized plagioclase crystals. While small clusters of rare fresh plagioclase grains from lava flows from Bustamante and Chacana displayed concordant plateau ages 119.4 ± 2.4 (2 sigma) and 118.7 ± 0.6 Ma, respectively, the adularia from the same formations gave sensibly younger ages around 94 Ma (high temperature steps), and 96.8 ± 0.2 Ma (plateau age) in Bustamante and Chacana, respectively. Sericite ages were measured in situ into single crystals of strongly transformed plagioclases. The relative proportion of sericite and plagioclase corresponding to each degasing step was monitored by measuring the Ca/K ratio (deduced from 37ArCa/39Ar_K). While intermediate ages were measured on some sericite of both sites (corresponding to a variable but permanent contribution of plagioclase on each step), a plateau age of 97.0 ± 1.6 Ma (concordant with adularia) could be obtained on a strongly sericitized plagioclase

  6. Paleozoic accretionary orogenesis in the eastern Beishan orogen: constraints from zircon U-Pb and 40Ar/39Ar geochronology (United States)

    Ao, Songjian; Xiao, Wenjiao; Windley, Brian; Mao, Qigui


    The continental growth mechanism of the Altaids in Central Asia is still in controversy between models of continuous subduction-accretion versus punctuated accretion by closure of multiple oceanic basins. The Beishan orogenic belt, located in the southern Altaids, is a natural laboratory to address this controversy. Key questions that are heavily debated are: the closure time and subduction polarity of former oceans, the emplacement time of ophiolites, and the styles of accretion and collision. This paper reports new structural data, zircon ages and Ar-Ar dates from the eastern Beishan Orogen that provide information on the accretion process and tectonic affiliation of various terranes. Our geochronological and structural results show that the younging direction of accretion was northwards and the subduction zone dipped southwards under the northern margin of the Shuangyingshan micro-continent. This long-lived and continuous accretion process formed the Hanshan accretionary prism. Our field investigations show that the emplacement of the Xiaohuangshan ophiolite was controlled by oceanic crust subduction beneath the forearc accretionary prism of the Shuangyingshan-Mazongshan composite arc to the south. Moreover, we address the age and terrane affiliation of lithologies in the eastern Beishan orogen through detrital zircon geochronology of meta-sedimentary rocks. We provide new information on the ages, subduction polarities, and affiliation of constituent structural units, as well as a new model of tectonic evolution of the eastern Beishan orogen. The accretionary processes and crustal growth of Central Asia were the result of multiple sequences of accretion and collision of manifold terranes. Reference: Ao, S.J., Xiao, W., Windley, B.F., Mao, Q., Han, C., Zhang, J.e., Yang, L., Geng, J., Paleozoic accretionary orogenesis in the eastern Beishan orogen: Constraints from zircon U-Pb and 40Ar/39Ar geochronology. Gondwana Research, doi:

  7. The Relationship between Reports of Psychological Capital and Reports of Job Satisfaction among Administrative Personnel at a Private Institution of Higher Education (United States)

    Mello, James A.


    The purpose of this single-site case study was to investigate the relationship between administrative personnel's reports of psychological capital (Luthans, Youssef, & Avolio, 2007) and their reports of job satisfaction (Hackman & Oldham, 1980). Specifically, two surveys, the Psychological Capital Questionnaire (Luthans, Youssef, &…

  8. Malaysia and the Knowledge Economy: Building a World-Class Higher Education System. Human Development Sector Reports (United States)

    Regel, Omporn; Salmi, Jamil; Watkins, Alfred; Tan, Hong; Dawkins, John; Saroyan, Alenoush; Vestergaard, Jakob


    This report was prepared at the request of the Government of Malaysia (GOM) as a contribution to the long term development objectives for the university sector under the Ninth Malaysia Plan. The GOM is considering new policy directions to make the country a more competitive player in the world economy. Such a strategy will require bold innovations…

  9. Young adolescents who combine alcohol and energy drinks have a higher risk of reporting negative behavioural outcomes

    NARCIS (Netherlands)

    Holubcikova, Jana; Kolarcik, Peter; Madarasova Geckova, Andrea; Joppova, Eva; van Dijk, Jitse P; Reijneveld, Sijmen A


    OBJECTIVES: To explore whether young adolescents consuming alcohol and energy drinks combined were more likely to report negative behavioural outcomes than their peers who drink only one type of these beverages or are abstinent. METHODS: We analysed data on a representative sample of Slovak adolesce

  10. Young adolescents who combine alcohol and energy drinks have a higher risk of reporting negative behavioural outcomes

    NARCIS (Netherlands)

    Holubcikova, Jana; Kolarcik, Peter; Geckova, Andrea Madarasova; Joppova, Eva; van Dijk, Jitse P.; Reijneveld, Sijmen A.

    To explore whether young adolescents consuming alcohol and energy drinks combined were more likely to report negative behavioural outcomes than their peers who drink only one type of these beverages or are abstinent. We analysed data on a representative sample of Slovak adolescents 8502 adolescents

  11. Piecing Together the Student Success Puzzle: Research, Propositions, and Recommendations. ASHE Higher Education Report, Volume 32, Number 5 (United States)

    Kuh, George D., Ed.; Kinzie, Jillian, Ed.; Buckley, Jennifer A., Ed.; Bridges, Brian K., Ed.; Hayek, John C., Ed.


    This report is an abridged version of work performed for the National Postsecondary Education Cooperative to synthesize the relevant literature and emerging findings related to student success, broadly defined (Kuh and others, 2006). The author's purpose is to provide an informed perspective on policies, programs, and practices that can make a…

  12. Exploring the Validity and Robustness of a Competency Self-Report Instrument for Vocational and Higher Competence-Based Education

    NARCIS (Netherlands)

    Khaled, A.E.; Gulikers, J.T.M.; Tobi, H.; Biemans, H.J.A.; Oonk, C.; Mulder, M.


    Research on the effectiveness of competence-based education (CB-education) across educational contexts and levels requires a new evaluation measurement. This study explores the face validity, construct validity, and robustness of a competency self-report instrument that is aligned with contemporary

  13. Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer. (United States)

    Foley, Christopher; Mitsiades, Nicholas


    Medical or surgical castration serves as the backbone of systemic therapy for advanced and metastatic prostate cancer, taking advantage of the importance of androgen signaling in this disease. Unfortunately, resistance to castration emerges almost universally. Despite the development and approval of new and more potent androgen synthesis inhibitors and androgen receptor (AR) antagonists, prostate cancers continue to develop resistance to these therapeutics, while often maintaining their dependence on the AR signaling axis. This highlights the need for innovative therapeutic approaches that aim to continue disrupting AR downstream signaling but are orthogonal to directly targeting the AR itself. In this review, we discuss the preclinical research that has been done, as well as clinical trials for prostate cancer, on inhibiting several important families of AR-interacting proteins, including chaperones (such as heat shock protein 90 (HSP90) and FKBP52), pioneer factors (including forkhead box protein A1 (FOXA1) and GATA-2), and AR transcriptional coregulators such as the p160 steroid receptor coactivators (SRCs) SRC-1, SRC-2, SRC-3, as well as lysine deacetylases (KDACs) and lysine acetyltransferases (KATs). Researching the effect of-and developing new therapeutic agents that target-the AR signaling axis is critical to advancing our understanding of prostate cancer biology, to continue to improve treatments for prostate cancer and for overcoming castration resistance.

  14. Modification of stearic acid in Ar and Ar-O{sub 2} pulsed DC discharges

    Energy Technology Data Exchange (ETDEWEB)

    Bernardelli, E.A.; Souza, T.; Maliska, A.M.; Kleinjohann, K.J.; Bendo, T. [Federal University of Santa Catarina (UFSC), Florianopolis, SC (Brazil); Mafra, M. [Nancy-Universite (France). Institut Jean Lamour; CNRS, Nancy (France); Belmonte, T. [Federal University of Technology from Parana (UTFPR), Curitiba, PR (Brazil)


    Stearic acid (C{sub 1}8H{sub 36}O{sub 2}) was treated into Ar and Ar-O{sub 2}(10%) pulsed DC discharge created by a cathode-anode confined system. The samples were placed at the floating potential. The results show that the mass variation of the stearic acid samples after Ar-O{sub 2} plasma exposure is more important than the pure Ar plasma treatments. This comportment demonstrate that the oxygen actives species (O and O{sub 2} in all states) strongly enhance the etching process with regards to A{sup *} species, regardless of their concentration. After treatment by Ar and Ar-O{sub 2} plasma, analyses by X-ray diffraction show a significant structural modification of the samples surface, utilizing Ar-O{sub 2} plasma the modification was more pronounced. The chemical composition evolution shows that the acid function is etched preferentially in the beginning of the treatment (about 5 min) and that after 10 min the carbonic chains seems to be functionalized by oxygen. (author)

  15. TBLR1 as an AR coactivator selectively activates AR target genes to inhibit prostate cancer growth (United States)

    Daniels, Garrett; Li, Yirong; Gellert, Lan Lin; Zhou, Albert; Melamed, Jonathan; Wu, Xinyu; Zhang, Xinming; Zhang, David; Meruelo, Daniel; Logan, Susan K.; Basch, Ross; Lee, Peng


    Androgen Receptor (AR), a steroid hormone receptor, is critical for prostate cancer growth. However, activation of AR by androgens can also lead to growth suppression and differentiation. Transcriptional cofactors play an important role in this switch between proliferative and anti-proliferative AR target gene programs. TBLR1, a core component of the nuclear receptor corepressor (NCoR) complex, shows both co-repressor and co-activator activities on nuclear receptors, but little is known about its effects on AR and prostate cancer. We characterized TBLR1 as a coactivator of AR in prostate cancer cells and the activation is both phosphorylation and 19S proteosome dependent. We showed that TBLR1 physically interacts with AR and directly occupies the androgen response elements of affected AR target genes in an androgen-dependent manner. TBLR1 is primarily localized in the nucleus in benign prostate cells and nuclear expression is significantly reduced in prostate cancer cells in culture. Similarly, in human tumor samples, the expression of TBLR1 in the nucleus is significantly reduced in the malignant glands compared to the surrounding benign prostatic glands (p<0.005). Stable ectopic expression of nuclear TBLR1 leads to androgen-dependent growth suppression of prostate cancer cells in vitro and in vivo by selective activation of androgen regulated genes associated with differentiation (e.g. KRT18) and growth suppression (e.g. NKX3.1), but not cell proliferation of the prostate. Understanding the molecular switches involved in the transition from AR dependent growth promotion to AR dependent growth suppression will lead to more successful prostate cancer treatments. PMID:24243687

  16. Potassium Isotopic Compositions of NIST Potassium Standards and 40Ar/39Ar Mineral Standards (United States)

    Morgan, Leah; Tappa, Mike; Ellam, Rob; Mark, Darren; Higgins, John; Simon, Justin I.


    Knowledge of the isotopic ratios of standards, spikes, and reference materials is fundamental to the accuracy of many geochronological methods. For example, the 238U/235U ratio relevant to U-Pb geochronology was recently re-determined [1] and shown to differ significantly from the previously accepted value employed during age determinations. These underlying values are fundamental to accurate age calculations in many isotopic systems, and uncertainty in these values can represent a significant (and often unrecognized) portion of the uncertainty budget for determined ages. The potassium isotopic composition of mineral standards, or neutron flux monitors, is a critical, but often overlooked component in the calculation of K-Ar and 40Ar/39Ar ages. It is currently assumed that all terrestrial materials have abundances indistinguishable from that of NIST SRM 985 [2]; this is apparently a reasonable assumption at the 0.25per mille level (1s) [3]. The 40Ar/39Ar method further relies on the assumption that standards and samples (including primary and secondary standards) have indistinguishable 40K/39K values. We will present data establishing the potassium isotopic compositions of NIST isotopic K SRM 985, elemental K SRM 999b, and 40Ar/39Ar biotite mineral standard GA1550 (sample MD-2). Stable isotopic compositions (41K/39K) were measured by the peak shoulder method with high resolution MC-ICP-MS (Thermo Scientific NEPTUNE Plus), using the accepted value of NIST isotopic SRM 985 [2] for fractionation [4] corrections [5]. 40K abundances were measured by TIMS (Thermo Scientific TRITON), using 41K/39K values from ICP-MS measurements (or, for SRM 985, values from [2]) for internal fractionation corrections. Collectively these data represent an important step towards a metrologically traceable calibration of 40K concentrations in primary 40Ar/39Ar mineral standards and improve uncertainties by ca. an order of magnitude in the potassium isotopic compositions of standards.

  17. 78 FR 9448 - Arkansas Disaster #AR-00061 (United States)


    ... ADMINISTRATION Arkansas Disaster AR-00061 AGENCY: U.S. Small Business Administration. ACTION: Notice SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  18. "Ars Dictaminis" and Modern Rhetorical Practice. (United States)

    Sewell, Ernestine P.

    Although not all the problems of writing are solved by practice in letter writing, a review of the classical texts on "ars dictaminis"--letter writing--creates a strong argument for its increased use as an exercise in college composition classrooms. By incorporating the lessons of dictamen as a device for achieving rhetorical modes--narration,…

  19. User Interface Design for Military AR Applications (United States)


    SI: AUGMENTED REALITY User interface design for military AR applications Mark A. Livingston • Zhuming Ai • Kevin Karsch • Gregory O. Gibson Received...several visual representations fundamental to SA. The UI M. A. Livingston (&) Z. Ai K. Karsch G. O. Gibson Naval Research Laboratory, Washington

  20. "ARS 01", perspektiivide avamine / Helen Kivisoo

    Index Scriptorium Estoniae

    Kivisoo, Helen


    30. IX 2001-20. I 2002 Kiasmas kuuendat korda toimuvast rahvusvahelisest näitusest "ARS", kus Eestist osaleb Marko Mäetamm. Kuraatorid Tuula Arkio, Maaretta Jaukkuri, Patrik Nyberg, Jari-Pekka Vanhala. Teemaks "kolmas ruum". Näituse kajastamisest.

  1. Brief Report: Parent-Adolescent Informant Discrepancies of Social Skill Importance and Social Skill Engagement for Higher-Functioning Adolescents with Autism Spectrum Disorder (United States)

    McMahon, Camilla M.; Solomon, Marjorie


    Parent- and adolescent-report of social skill importance and social skill engagement on the Social Skills Rating System (Gresham and Elliott in The social skills rating system, American Guidance Service, Circle Pines, 1990) were assessed in higher-functioning adolescents with Autism Spectrum Disorder (ASD). Compared to parents, adolescents…

  2. Theoretical prediction on vibrational spectra of [Ar…Ar-H]+

    Institute of Scientific and Technical Information of China (English)

    LI; Wei(李巍); ZHAO; Xinsheng(赵新生)


    Centrosymmetric linear [Ar-H-Ar]+ and asymmetric linear [Ar…Ar-H]+ are two stable configurations of [Ar2H]+. Based on the global potential energy surface of [Ar2H]+ provided by our group recently, we calculated the vibrational spectra of [Ar…Ar-H]+ with total angular momentum J = 0 by time-dependent quantum mechanical method, and the influence of quantum tunneling effect on vibrational spectra was found. With the help of the observation on the eigenstate functions and the modified potential energy surface, assignments were made to the spectra. The strong coupling between the excited bending mode of [Ar-H-Ar]+ and the vibrational states of [Ar…Ar-H]+ was discussed.

  3. Metalloregulatory properties of the ArsD repressor. (United States)

    Chen, Y; Rosen, B P


    The plasmid-encoded arsenical resistance (ars) operon of plasmid R773 produces resistance to trivalent and pentavalent salts of the metalloids arsenic and antimony in cells of Escherichia coli. The first two genes in the operon, arsR and arsD, were previously shown to encode trans-acting repressor proteins. ArsR controls the basal level of expression of the operon, while ArsD controls maximal expression. Thus, action of the two repressors form a homeostatic regulatory circuit that maintains the level of ars expression within a narrow range. In this study, we demonstrate that ArsD binds to the same site on the ars promoter element as ArsR but with 2 orders of magnitude lower affinity. The results of gel shift assays demonstrate that ArsD is released from the ars DNA promoter by phenylarsine oxide, sodium arsenite, and potassium antimonyl tartrate (in order of effectiveness), the same inducers to which ArsR responds. Using the quenching of intrinsic tryptophan fluorescence to measure the affinity of the repressor for inducers, apparent Kd values for Sb(III) and As(III) of 2 and 60 microM, respectively, were obtained. These results demonstrate that the arsR-arsD pair provide a sensitive mechanism for sensing a wide range of environmental heavy metals.

  4. The burden of allergic rhinitis (AR in Canada: perspectives of physicians and patients

    Directory of Open Access Journals (Sweden)

    Keith Paul K


    Full Text Available Abstract Background Allergic rhinitis (AR is a common problem and we sought to examine the burden of disease and its management in Canada from the perspectives of patients and physicians. Methods Two parallel, Canadawide structured telephone interviews surveyed 1,001 AR patients and 160 physicians in July 2006. Results 44% of patients had experienced nasal symptoms unrelated to a cold and 20% had a physician diagnosis of AR. At screening 27% reported asthma, 15% chronic or recurrent sinusitis and 5% nasal polyps. With attacks nasal congestion and runny nose were the most bothersome symptoms. Other problems experienced were fatigue (46%, poor concentration (32%, and reduced productivity (23%. Most (77% had not seen a physician in the past year. Physicians estimated they prescribed intranasal cortico steroids (INCS to most AR patients (77% consistent with guidelines but only 19% of patients had used one in the last month. Only 48% of patients were very satisfied with their current INCS. 41% of AR patients reported discontinuing their INCS with the most common reason being a perceived lack of long-lasting symptom relief (44%. 52% of patients felt that their current INCS lost effectiveness over 24 h. The most common INCS side effects included dripping down the throat, bad taste, and dryness. Most AR patients reported lifestyle limitations despite treatment (66%. 61% of patients felt that their symptoms were only somewhat controlled or poorly/not controlled during their worst month in the past year. Conclusions AR symptoms are common and many patients experience inadequate control. Physicians report they commonly prescribe intranasal corticosteroids, but patient’s perceived loss of efficacy and side effects lead to their discontinuation. Persistent relief of allergic rhinitis symptoms remains a major unmet need. Better treatments and education are required.

  5. Construction of a chimeric ArsA-ArsB protein for overexpression of the oxyanion-translocating ATPase. (United States)

    Dou, D; Owolabi, J B; Dey, S; Rosen, B P


    Resistance to toxic oxyanions of arsenic and antimony in Escherichia coli is conferred by the conjugative R-factor R773, which encodes an ATP-driven anion extrusion pump. The ars operon is composed of three structural genes, arsA, arsB, and arsC. Although transcribed as a single unit, the three genes are differentially expressed as a result of translational differences, such that the ArsA and ArsC proteins are produced in high amounts relative to the amount of ArsB protein made. Consequently, biochemical characterization of the ArsB protein, which is an integral membrane protein containing the anion-conducting pathway, has been limited, precluding studies of the mechanism of this oxyanion pump. To overexpress the arsB gene, a series of changes were made. First, the second codon, an infrequently used leucine codon, was changed to a more frequently utilized codon. Second, a GC-rich stem-loop (delta G = -17 kcal/mol) between the third and twelfth codons was destabilized by changing several of the bases of the base-paired region. Third, the re-engineered arsB gene was fused 3' in frame to the first 1458 base pairs of the arsA gene to encode a 914-residue chimeric protein (486 residues of the ArsA protein plus 428 residues of the mutated ArsB protein) containing the entire re-engineered ArsB sequence except for the initiating methionine. The ArsA-ArsB chimera has been overexpressed at approximately 15-20% of the total membrane proteins. Cells producing the chimeric ArsA-ArsB protein with an arsA gene in trans excluded 73AsO2- from cells, demonstrating that the chimera can function as a component of the oxyanion-translocating ATPase.


    Energy Technology Data Exchange (ETDEWEB)

    Cueto, M.; Herrero, V. J.; Tanarro, I.; Doménech, J. L. [Molecular Physics Department, Instituto de Estructura de la Materia (IEM-CSIC), Serrano 123, E-28006 Madrid (Spain); Cernicharo, J. [Department of Astrophysics, CAB. INTA-CSIC. Crta Torrejón-Ajalvir Km 4, E-28850 Torrejón de Ardoz, Madrid (Spain); Barlow, M. J.; Swinyard, B. M., E-mail: [Department of Physics and Astronomy, University College London. Gower Street, London WC1E 6BT (United Kingdom)


    The protonated argon ion, {sup 36}ArH{sup +}, was recently identified in the Crab Nebula from Herschel spectra. Given the atmospheric opacity at the frequency of its J = 1-0 and J = 2-1 rotational transitions (617.5 and 1234.6 GHz, respectively), and the current lack of appropriate space observatories after the recent end of the Herschel mission, future studies on this molecule will rely on mid-infrared observations. We report on accurate wavenumber measurements of {sup 36}ArH{sup +} and {sup 38}ArH{sup +} rotation-vibration transitions in the v = 1-0 band in the range 4.1-3.7 μm (2450-2715 cm{sup –1}). The wavenumbers of the R(0) transitions of the v = 1-0 band are 2612.50135 ± 0.00033 and 2610.70177 ± 0.00042 cm{sup –1} (±3σ) for {sup 36}ArH{sup +} and {sup 38}ArH{sup +}, respectively. The calculated opacity for a gas thermalized at a temperature of 100 K and with a linewidth of 1 km s{sup –1} of the R(0) line is 1.6 × 10{sup –15} × N({sup 36}ArH{sup +}). For column densities of {sup 36}ArH{sup +} larger than 1 × 10{sup 13} cm{sup –2}, significant absorption by the R(0) line can be expected against bright mid-IR sources.

  7. Experimental measurements of the hollow cathode DC glow discharge parameters in Ar and He plasmas (United States)

    Omrani, M.; Amrollahi, R.; Iraji, D.


    In this article, we focus on some of the fundamental parameters of SS316L hollow cathode glow discharge. Four SS316L samples are placed at different locations on the cathode surface and the current passed through them is measured in Ar and He glow discharge plasmas. The wall current densities of Ar and He are in the range of 8-25 µA cm-2 and 8-35 µA cm-2, respectively. Results also show that with decreasing working pressure, the ion flux and current density distribution on the wall surface becomes more uniform. The ion flux of the Ar and He is in the range of 1013 to 1014 ~\\text{ion} \\text{c}{{\\text{m}}-2} . Total energy losses of Ar and He are measured at the pressure range of 1.4-5.5  ×  10-2 torr and 3.2-7.1  ×  10-1, respectively. In both Ar and He, total energy losses decreased with increasing pressure. The secondary electron emission coefficients of Ar and He, which are evaluated for the hallow cathode configuration, are about 0.42 and 0.26, respectively, and are higher in comparison with the plate cathode configuration.

  8. Use of 41Ar production to measure ablator areal density in NIF beryllium implosions (United States)

    Wilson, D. C.; Cassata, W. B.; Sepke, S. M.; Velsko, C. A.; Huang, H.; Yeamans, C. B.; Kline, J. L.; Yi, A.; Simakov, A. N.; Haan, S. W.; Batha, S. H.; Dewald, E. L.; Rygg, J. R.; Tommasini, R.; Xu, H.; Kong, C.; Bae, J.; Rice, N.


    For the first time, 41Ar produced by the (n,ϒ) reaction from 40Ar in the beryllium shell of a DT filled Inertial Confinement Fusion capsule has been measured. Ar is co-deposited with beryllium in the sputter deposition of the capsule shell. Combined with a measurement of the neutron yield, the radioactive 41Ar then quantifies the areal density of beryllium during the DT neutron production. The measured 1.15 ± 0.17 × 10+8 atoms of 41Ar are 2.5 times that from the best post-shot calculation, suggesting that the Ar and Be areal densities are correspondingly higher than those calculated. Possible explanations are that (1) the beryllium shell is compressed more than calculated, (2) beryllium has mixed into the cold DT ice, or more likely (3) less beryllium is ablated than calculated. Since only one DT filled beryllium capsule has been fielded at NIF, these results can be confirmed and expanded in the future.

  9. Postcollision interactions in the Auger decay of the Ar L-shell

    Energy Technology Data Exchange (ETDEWEB)

    Samson, J.A.R.; Stolte, W.C.; He, Z.X. [Univ. of Nebraska, Lincoln, NE (United States)] [and others


    The photoionization cross sections for Ar{sup +} through Ar{sup 4+}, produced by the Auger decay of an inner shell 2p hole, have been measured between 242 eV and 253 eV on beamline 9.0.1 and 6.3.2. In this study the authors are interested in near threshold phenomenon involving postcollision interactions (PCI), which are related to the Auger decay of a vacancy in the Ar L-shell. During an Auger decay a postcollision interaction can occur causing the out-going photoelectron to be retarded thus losing a certain amount of energy. If the retardation is sufficiently large the photoelectron will not escape. This result produces a singly charged ion, which normally would not be present. Such evidence of electron capture by the PCI effect was first shown clearly by Eberhardt et al. and, with higher resolution, in the present work. However, capture of the photoelectron is expected to be 100% exactly at the L{sub 2,3} thresholds. Thus, from the authors results they would have expected the Ar{sup 2+} signal to be zero at threshold, but it was not? The authors can explain this anomoly on the basis that during the Auger decay the photoelectrons are captured into high lying excited states of Ar{sup +}, which subsequently decay through autoionization yielding Ar{sup 2+}. Future work in this area will seek experimental evidence to verify this prediction.

  10. Self-reported leadership styles of deans of baccalaureate and higher degree nursing programs in the United States. (United States)

    Broome, Marion E


    Over the past decade there has been a lack of attention in the discipline paid to developing strong academic leaders. It is widely acknowledged that the role of the dean has shifted dramatically over the past two decades, with an increasing emphasis on interaction with and accountability to external constituencies at the university, community, and national levels. The overall purpose of this study was to investigate the self-reported leadership styles, behaviors, and experiences of deans of schools of nursing in the United States. The Multifactor Leadership Questionnaire (MLQ) was sent to 655 deans who were members of the American Association of Colleges of Nursing; 344 returned completed surveys for a return rate of 52.5%. Scores on the transformational scale (n = 321; 20 items) ranged from 2.75 to 4.0, with a mean of 3.79; transactional scores ranged from 1.3 to 4.0, with a mean of 3.3 and mode of 3.5. The passive leadership component was lowest, with a range of 0 to 3.75, mean of 1.1, and mode of 1.0. The highest scores for each dean were then examined and compared across the three components. Seventy-seven percent of the deans' highest scores fell on the transformational, 21% on the transactional, and 2% on the passive-avoidant scale. There were no significant differences in the most commonly reported leadership behaviors by gender, ethnicity, or terminal degree. Deans of nursing, compared with over 3,000 other leaders who have completed the MLQ, ranked in the 80th percentile for self-reported transformative behaviors and outcomes effectiveness. The findings from this sample, who were predominantly female, are congruent with previous research on women leaders. Recommendations for future research leadership development programs are presented.

  11. Sensitivity for Diagnosing Group A Streptococcal Pharyngitis from Manufacturers is 10% Higher than Reported in Peer-Reviewed Publications. (United States)

    Vachhani, Raj; Patel, Toral; Centor, Robert M; Estrada, Carlos A


    Meta-analyses based on peer-reviewed publications report a sensitivity of approximately 85% for rapid antigen streptococcus tests to diagnose group A streptococcal (GAS) pharyngitis. Because these meta-analyses excluded package inserts, we examined the test characteristics of rapid antigen streptococcal tests and molecular methods that manufacturers report in their package inserts. We included tests available in the US market (Food and Drug Administration, period searched 1993-2015) and used package insert data to calculate pooled sensitivity and specificity. To examine quality, we used the Quality Assessment of Diagnostic Accuracy Studies-2. We excluded 26 tests having different trade names but identical methods and data. The study design was prospective in 41.7% (10 of 24). The pooled sensitivity of the most commonly used method, lateral flow/immunochromatographic, was 95% (95% confidence interval [CI] 94-96) and the pooled specificity was 98% (96-98); 7108 patients. The pooled sensitivity of the polymerase chain reaction or molecular methods was 98% (95% CI 96-98) and the pooled specificity was 96% (95% CI 95-97); 5685 patients. Package inserts include sponsored studies that overestimate the sensitivity of rapid tests to diagnose GAS pharyngitis by approximately 10%. Physicians should understand that package inserts overestimate diagnostic test utility; a negative test cannot be used to exclude GAS pharyngitis.

  12. Recoil ion charge state distributions in low energy Ar{sup q+} {minus} Ar collisions

    Energy Technology Data Exchange (ETDEWEB)

    Vancura, J.; Marchetti, V.; Kostroun, V.O.


    We have measured the recoil ion charge state distributions in Ar{sup q+} -- Ar (8{le}q{le}16) collisions at 2.3 qkeV and 0.18qkeV by time of flight (TOF) spectroscopy. For Ar{sup 8-16+}, recoil ion charge states up to 6+ are clearly present, indicating that the 3p subshell in the target atom is being depleted, while for Ar{sup 10-16+}, there is evidence that target 3s electrons are also being removed. Comparison of the recoil ion charge state spectra at 2.3 and 0.18 qkeV shows that for a given projectile charge, there is very little dependence of the observed recoil target charge state distribution on projectile energy.

  13. Blood pressure, heart rate and tubuloglomerular feedback in A1AR-deficient mice with different genetic backgrounds. (United States)

    Kim, S M; Mizel, D; Qin, Y; Huang, Y; Schnermann, J


    Differences in genetic background between control mice and mice with targeted gene mutations have been recognized as a potential cause for phenotypic differences. In this study, we have used A1AR-deficient mice in a C57Bl/6 and SWR/J congenic background to assess the influence of background on the effect of A1AR-deficiency on cardiovascular and renal functional parameters. In A1AR+/+ and A1AR-/- mice in C57Bl/6 and SWR/J congenic backgrounds, we assessed blood pressure and heart rate using radio-telemetry, plasma renin concentrations and tubuloglomerular feedback. We did not detect significant differences in arterial blood pressure (MAP) and heart rates (HR) between A1AR+/+ and A1AR-/- mice in either C57Bl/6, SWR/J or mixed backgrounds. MAP and HR were significantly higher in SWR/J than in C57Bl/6 mice. A high NaCl intake increased MAP in A1AR-/- mice on C57Bl/6 background while there was less or no salt sensitivity in the SWR/J background. No significant differences in plasma renin concentration were detected between A1AR-/- and A1AR+/+ mice in any of the strains. Tubuloglomerular feedback was found to be absent in A1AR-/- mice with SWR/J genetic background. While this study confirmed important differences between inbred mouse strains, we did not identify phenotypic modifications of A1AR-related effects on blood pressure, heart rate and plasma renin by differences in genetic background. © 2014 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

  14. An EIAV field isolate reveals much higher levels of subtype variability than currently reported for the equine lentivirus family

    Directory of Open Access Journals (Sweden)

    Zhang Baoshan


    Full Text Available Abstract Background Equine infectious anemia virus (EIAV, a lentivirus that infects horses, has been utilized as an animal model for the study of HIV. Furthermore, the disease associated with the equine lentivirus poses a significant challenge to veterinary medicine around the world. As with all lentiviruses, EIAV has been shown to have a high propensity for genomic sequence and antigenic variation, especially in its envelope (Env proteins. Recent studies have demonstrated Env variation to be a major determinant of vaccine efficacy, emphasizing the importance of defining natural variation among field isolates of EIAV. To date, however, published EIAV sequences have been reported only for cell-adapted strains of virus, predominantly derived from a single primary virus isolate, EIAVWyoming (EIAVWY. Results We present here the first characterization of the Env protein of a natural primary isolate from Pennsylvania (EIAVPA since the widely utilized and referenced EIAVWY strain. The data demonstrated that the level of EIAVPA Env amino acid sequence variation, approximately 40% as compared to EIAVWY, is much greater than current perceptions or published reports of natural EIAV variation between field isolates. This variation did not appear to give rise to changes in the predicted secondary structure of the proteins. While the EIAVPA Env was serologically cross reactive with the Env proteins of the cell-adapted reference strain, EIAVPV (derivative of EIAVWY, the two variant Envs were shown to lack any cross neutralization by immune serum from horses infected with the respective virus strains. Conclusion Taking into account the significance of serum neutralization to universal vaccine efficacy, these findings are crucial considerations towards successful EIAV vaccine development and the potential inclusion of field isolate Envs in vaccine candidates.

  15. Higher Spins in Hyperspace

    CERN Document Server

    Florakis, Ioannis; Tsulaia, Mirian


    We consider the Sp(2n) invariant formulation of higher spin fields on flat and curved backgrounds of constant curvature.In this formulation an infinite number of higher spin fields are packed into single scalar and spinor master fields (hyperfields) propagating on extended spaces, to be called hyperspaces, parametrized by tensorial coordinates.We show that the free field equations on flat and AdS-like hyperspaces are related to each other by a generalized conformal transformation of the scalar and spinor master fields. We compute the four--point functions on a flat hyperspace for both scalar and spinor master fields, thus extending the two-- and three--point function results of arXiv:hep-th/0312244. Then using the generalized conformal transformation we derive two--, three-- and four--point functions on AdS--like hyperspace from the corresponding correlators on the flat hyperspace.

  16. Additional /sup 40/Ar-/sup 39/Ar dating of the basement and the alkaline volcanism of Gorringe Bank (Atlantic Ocean)

    Energy Technology Data Exchange (ETDEWEB)

    Feraud, G.; York, D.; Mevel, C.; Cornen, G.; Hall, C.M.; Auzende, J.M.


    /sup 40/Ar//sup 39/Ar step heating analyses are reported for a variety of samples from Gorringe Bank (Atlantic Ocean). Flat age spectra for two primary, igneous hornblendes of Gorringe (corresponding to an age of 143 Ma) show that the K-Ar ages obtained on these samples by Prichard and Mitchell are evidently crystallization and not hybrid ages. This sustains the concept of an initiation age of 140 Ma for Gorringe Bank. No support is found for Carpena's suggestion that the formation of Gorringe Bank began 200 Ma ago. Secondary hornblendes from Ormonde seamount rocks appear to have formed shortly after the initiation of the Bank. Precise plateau ages on samples of two alkaline volcanics from Ormonde correspond to the older limit of the alkaline volcanism suggested by Feraud et al.

  17. Comments on the report "Indications of anomalous heat energy production in a reactor device containing hydrogen loaded nickel powder" [arXiv:1305.3913] by G.Levi, E.Foschi, T.Hartman, B.H\\"oistad, R.Pettersson, L.Tegn\\'er, H.Ess\\'en

    CERN Document Server

    Ericsson, Göran


    In a recent report titled "Indications of anomalous heat energy production in a reactor device containing hydrogen loaded nickel powder" [arXiv:1305.3913], G. Levi and co-workers put forth several claims concerning the operations and performance of the so-called E-Cat of Andrea Rossi. We note first of all that the circumstances and people involved in the test make if far from being an independent one. We examine the claims put forth by the authors and note that in many cases they are not supported by the facts given in the report. The authors seem to jump to conclusions fitting pre-conceived ideas where alternative explanations are possible. In general we find that much attention is drawn to trivialities while important pieces of information and investigation are lacking and seem not to have been conducted or considered. These are characteristics more typically found in pseudo-scientific texts and have no place in a technical/scientific report on this level. We also note that the proposed claims would require...


    Institute of Scientific and Technical Information of China (English)

    P.Wu; F.P.Wang; L.Q.Pan; Y.Tian; H.Qiu


    Cu films with thickness of 630-1300nm were deposited on glass substrates withoutheating by DC magnetron sputtering in pure Ar gas. Ar pressure was controlled to0.5, 1.0 and 1.5Pa respectively. The target voltage was fixed at 500V but the targetcurrent increased from 200 to 1150mA with Ar pressure increasing. X-ray diffrac-tion, scanning electron microscopy and atomic force microscopy were used to observethe structural characterization of the films. The resistivity of the films was measuredusing four-point probe technique. At all the Ar pressures, the Cu films have mixturecrystalline orientations of [111], [200] and [220] in the direction of the film growth.The film deposited at lower pressure shows more [111] orientation while that depositedat higher pressure has more [220] orientation. The amount of larger grains in the filmprepared at 0.5Pa Ar pressure is slightly less than that prepared at 1. 0Pa and 1.5PaAr pressures. The resistivities of the films prepared at three different Ar pressures rep-resent few differences, about 3-4 times of that of bulk material. Besides the depositionrate increases with Ar pressure because of the increase in target current. The contri-bution of the bombardment of energetic reflected Argon atoms to these phenomena isdiscussed.

  19. Millennial-scale phase relationships between ice-core and Mediterranean marine records: insights from high-precision 40Ar/39Ar dating of the Green Tuff of Pantelleria, Sicily Strait (United States)

    Scaillet, S.; Vita-Scaillet, G.; Rotolo, S. G.


    With the advent of annually-resolved polar ice records extending back to 70 ka, marine and continental paleoclimate studies have now matured into a discipline where high-quality age control is essential for putting on an equal pace layer-counted timescale models and Late Quaternary sedimentary records. High-resolution U-Th dating of speleothem records and 40Ar/39Ar dating of globally recorded geomagnetic excursions have recently improved the time calibration of Quaternary archives, reflecting the cross-disciplinary effort made to synchronize the geologic record at the millennial scale. Yet, tie-points with such an absolute age control remain scarce for paleoclimatic time-series extending beyond the radiocarbon timescale, most notably in the marine record. Far-travelled tephra layers recorded both onland and offshore provide an alternative in such instance to synchronize continental and marine archives via high-resolution 40Ar/39Ar dating of the parent volcanic eruption. High-resolution 40Ar/39Ar data are reported herein for one such volcanic marker, the Green Tuff of Pantelleria and its Y-6 tephra equivalent recorded throughout the Central and Eastern Mediterranean. Published radiochronometric and δ18O orbitally-tied ages for this marker horizon scatter widely from about 41 ka up to 56 ka. Our new 40Ar/39Ar age at 45.7 ± 1.0 ka (2σ) reveals that previous estimates are biased by more than their reported errors would suggest, including recent orbital tuning of marine records hosting the tephra bed that are reevaluated in the context of this study. This improved estimate enables potential phase lags and leads to be studied between deep-sea and terrestrial archives with unrivaled (near-millennial) 40Ar/39Ar precision in the marine record.

  20. The new 39Ar/40Ar dating facility of the LSCE, background and performances. (United States)

    Scaillet, S.; Nomade, S.; Guillou, H.; Scaillet-Vita, G.


    Precise and accurate timescales are increasingly needed in most disciplines of the Earth sciences. To contribute to this challenging task, a new 39Ar/40Ar laboratory, specifically devoted to the dating of very recent (down to 1 ka) volcanic products, has been developed at the LSCE (CEA-IPSL-UVSQ, France). In this contribution, we present the first data obtained from this new facility. The laboratory comprises a VG 5400 mass spectrometer coupled with a high sensitivity and high dynamic range ion counting system. Gas extraction is achieved with a 25 watts C02 laser or a double vacuum furnace depending of the analyzed samples. The full metal vacuum and purification line feature a GP50 and a compact Ti flash getters which permit extremely low blank for all Argon isotopes (e.g. ~ 3.0 10e-19 Moles for 36Ar). Both analytical protocols and hardware were specifically developed and optimized to date extremely young samples. Analytical performances including protocols, flux monitoring as well mass spectrometer discrimination correction method will be presented in the light of data obtained over the last 10 months. All samples were irradiated, under cadmium, in the Β-1 position (~1.0 10e+13 fast n cm-2 s-1) of the 70MWh-1 OSIRIS reactor (Pierre Süe laboratory, CEA-Saclay, France). Irradiation package is composed of home-design Aluminium disks constituting a 4 cm stack (10 to 30 unknowns/irradiation). Analyzed neutrons flux standards indicate less than 1% variation along the 4cm stack and validate the use of this reactor for high-precision 39Ar/40Ar dating. The precision and accuracy of the facility has been checked from cross-comparison of international single grain standards including FCs (28.02Ma), ACR-2 (1.194Ma) and TCR (28.32Ma) using the most recent recommended values for these monitors. A total of 80 grains in two irradiations (10 and 120 minutes) will be presented in details. Results from single-grain analyses agree within errors with those proposed by Renne et al

  1. Final Report Project Activity Task ORD-FY04-002 Nevada System of Higher Education Quality Assurance Program

    Energy Technology Data Exchange (ETDEWEB)

    Smiecinski, Amy; Keeler, Raymond; Bertoia, Julie; Mueller, Terry; Roosa, Morris; Roosa, Barbara


    The principal purpose of DOE Cooperative Agreement DE-FC28-04RW12232 is to develop and continue providing the public and the U.S. Department of Energy’s (DOE) Office of Civilian Radioactive Waste Management (OCRWM) with an independently derived, unbiased body of scientific and engineering data concerning the study of Yucca Mountain as a potential high-level radioactive waste repository. Under this agreement, the Nevada System of Higher Education (NSHE), formerly the University and Community College System of Nevada (UCCSN), performs scientific or engineering research, and maintains and fosters collaborative working relationships between government and academic researchers. In performing these activities, the NSHE has already developed and implemented a Quality Assurance (QA) program, which was accepted by the DOE Office of Quality Assurance, under the previous Cooperative Agreement Number DE-FC28-98NV12081. The following describes the objectives of Project Activity 002 “Quality Assurance Program” under cooperative agreement DE-FC28-04RW12232. The objective of this QA program was to assure that data produced under the cooperative agreement met the OCRWM QA Requirements and Description (QARD) requirements for quality-affecting (Q) data. The QA Program was written to address specific QARD requirements historically identified and incorporated in Q activities to the degree appropriate for the nature, scope, and complexity of the activity. Additional QARD requirements were integrated into the program when required to complete a specific activity. NSHE QA staff developed a detailed matrix to address each QARD element, identifying the applicable requirements and specifying where each requirement is addressed in the QA program procedures, or identify requirements as “not applicable” to the QA program. Controlled documents were prepared in the form of QA procedures (QAPs) and implementing procedures (IPs). NSHE identified new QAPs and IPs when needed. NSHE PIs

  2. Higher Childhood Peer Reports of Social Preference Mediates the Impact of the Good Behavior Game on Suicide Attempt. (United States)

    Newcomer, Alison R; Roth, Kimberly B; Kellam, Sheppard G; Wang, Wei; Ialongo, Nicholas S; Hart, Shelley R; Wagner, Barry M; Wilcox, Holly C


    The Good Behavior Game (GBG) is a universal classroom-based preventive intervention directed at reducing early aggressive, disruptive behavior and improving children's social adaptation into the classroom. The GBG is one of the few universal preventive interventions delivered in early elementary school that has been shown to reduce the risk for future suicide attempts. This paper addresses one potential mechanism by which the GBG lowers the risk of later suicide attempt. In this study, we tested whether the GBG, by facilitating social adaptation into the classroom early on, including the level of social preference by classmates, thereby lowers future risk of suicide attempts. The measure of social adaptation is based on first and second grade peer reports of social preference ("which children do you like best?"; "which children don't you like?"). As part of the hypothesized meditational model, we examined the longitudinal association between childhood peer social preference and the risk of future suicide attempt, which has not previously been examined. Data were from an epidemiologically based randomized prevention trial, which tested the GBG among two consecutive cohorts of first grade children in 19 public schools and 41 classrooms. Results indicated that peer social preference partially mediated the relationship between the GBG and the associated reduction of risk for later suicide attempts by adulthood, specifically among children characterized by their first grade teacher as highly aggressive, disruptive. These results suggest that positive childhood peer relations may partially explain the GBG-associated reduction of risk for suicide attempts and may be an important and malleable protective factor for future suicide attempt.

  3. 40Ar* loss in experimentally deformed muscovite and biotite with implications for 40Ar/39Ar geochronology of naturally deformed rocks (United States)

    Cosca, M.; Stunitz, H.; Bourgeix, A.-L.; Lee, J.P.


    The effects of deformation on radiogenic argon (40Ar*) retentivity in mica are described from high pressure experiments performed on rock samples of peraluminous granite containing euhedral muscovite and biotite. Cylindrical cores, ???15mm in length and 6.25mm in diameter, were drilled from granite collected from the South Armorican Massif in northwestern France, loaded into gold capsules, and weld-sealed in the presence of excess water. The samples were deformed at a pressure of 10kb and a temperature of 600??C over a period 29 of hours within a solid medium assembly in a Griggs-type triaxial hydraulic deformation apparatus. Overall shortening in the experiments was approximately 10%. Transmitted light and secondary and backscattered electron imaging of the deformed granite samples reveals evidence of induced defects and for significant physical grain size reduction by kinking, cracking, and grain segmentation of the micas.Infrared (IR) laser (CO2) heating of individual 1.5-2.5mm diameter grains of muscovite and biotite separated from the undeformed granite yield well-defined 40Ar/39Ar plateau ages of 311??2Ma (2??). Identical experiments on single grains separated from the experimentally deformed granite yield results indicating 40Ar* loss of 0-35% in muscovite and 2-3% 40Ar* loss in biotite. Intragrain in situ ultraviolet (UV) laser ablation 40Ar/39Ar ages (??4-10%, 1??) of deformed muscovites range from 309??13 to 264??7Ma, consistent with 0-16% 40Ar* loss relative to the undeformed muscovite. The in situ UV laser ablation 40Ar/39Ar ages of deformed biotite vary from 301 to 217Ma, consistent with up to 32% 40Ar* loss. No spatial correlation is observed between in situ 40Ar/39Ar age and position within individual grains. Using available argon diffusion data for muscovite the observed 40Ar* loss in the experimentally treated muscovite can be utilized to predict average 40Ar* diffusion dimensions. Maximum 40Ar/39Ar ages obtained by UV laser ablation overlap those

  4. A variable CD3⁺ T-cell frequency in peripheral blood lymphocytes associated with type 1 diabetes mellitus development in the LEW.1AR1-iddm rat.

    Directory of Open Access Journals (Sweden)

    Tanja Arndt

    Full Text Available PURPOSE: The LEW.1AR1-iddm rat is an animal model of human type 1 diabetes mellitus (T1DM, which arose through a spontaneous mutation within the MHC-congenic inbred strain LEW.1AR1 (RT1(r². In contrast to the diabetes-resistant LEW.1AR1 background strain in LEW.1AR1-iddm rats a highly variable T-cell frequency could be observed in peripheral blood lymphocytes (PBLs. METHODS: In this study we therefore characterised the T-cell repertoire within the PBLs of the two strains by flow cytometry analysis and identified the CD3⁺ T-cell phenotype and its possible linkage to diabetes susceptibility. To map loci conferring susceptibility to variable CD3⁺ T-cell frequency, backcross strains (N2 were generated with the genetically divergent BN and PAR rats for microsatellite analysis. RESULTS: The LEW.1AR1-iddm rat strain was characterised by a higher variability of CD3⁺ T-cells in PBLs along with a slightly decreased mean value compared to the LEW.1AR1 background strain. The reason for this reduction was a decrease in the CD4⁺ T-cell count while the CD8⁺ T-cell proportion remained unchanged. However, both T-cell subpopulations showed a high variability. This resulted in a lower CD4⁺/CD8⁺ T-cell ratio than in LEW.1AR1 rats. Like LEW.1AR1-iddm rats all animals of the backcross populations, N2 BN and N2 PAR rats, also showed large variations of the CD3⁺ T-cell frequency. The phenotype of variable CD3⁺ T-cell frequency mapped to the telomeric region of chromosome 1 (RNO1, which is identical with the already known Iddm8 diabetes susceptibility region. The data indicate that a variable CD3⁺ T-cell frequency in PBLs is genetically linked to diabetes susceptibility in the LEW.1AR1-iddm rat. CONCLUSION: The T-cell variability in PBLs could be related to the previously reported imbalance between regulatory and effector T-cell populations which results in beta-cell autoimmunity. Since similar T-cell phenotypes have also been described in human T1

  5. On concentration of $^{42}$Ar in the Earth's atmosphere

    CERN Document Server

    Barabash, A S


    Data from the DBA liquid argon ionization chamber experiment have been used to obtain an estimate on the concentration of $^{42}$Ar in the Earth's atmosphere, $6.8^{+1.7}_{-3.2}\\cdot10^{-21}$ atoms of $^{42}$Ar per atom of $^{40}$Ar corresponding to the $^{42}$Ar activity of $1.2^{+0.3}_{-0.5}$ $\\mu$Bq per cubic meter of air.

  6. On concentration of 42Ar in the Earth's atmosphere (United States)

    Barabash, A. S.; Saakyan, R. R.; Umatov, V. I.


    Data from the DBA liquid argon ionization chamber experiment have been used to obtain an estimate on the concentration of 42Ar in the Earth's atmosphere, 6 .8-3.2+1.7 ·10-21 atoms of 42Ar per atom of 40Ar corresponding to the 42Ar activity of 1 .2-0.5+0.3 μBq per cubic meter of air.

  7. Enseñar un oficio, proponer una forma


    Vitale, Daniele


    El oficio de enseñar. Enseñar a través de la técnica, enseñar por vía de la cultura. Una ciudadela de figuras. Imitación y relación personal. Enseñar a partir de un sistema. Partir del inicio. Posponer la realidad Peer Reviewed

  8. Droplet Digital PCR Based Androgen Receptor Variant 7 (AR-V7 Detection from Prostate Cancer Patient Blood Biopsies

    Directory of Open Access Journals (Sweden)

    Yafeng Ma


    Full Text Available Androgen receptor splice variant V7 (AR-V7 was recently identified as a valuable predictive biomarker in metastatic castrate-resistant prostate cancer. Here, we report a new, sensitive and accurate screen for AR-V7 mRNA expression directly from circulating tumor cells (CTCs: We combined EpCAM-based immunomagnetic CTC isolation using the IsoFlux microfluidic platform with droplet digital polymerase chain reaction (ddPCR to analyze total AR and AR-V7 expression from prostate cancer patients CTCs. We demonstrate that AR-V7 is reliably detectable in enriched CTC samples with as little as five CTCs, even considering tumor heterogeneity, and confirm detection of AR-V7 in CTC samples from advanced prostate cancer (PCa patients with AR-V7 detection limited to castrate resistant disease status in our sample set. Sensitive molecular analyses of circulating tumor cells (CTCs or circulating tumor nucleic acids present exciting strategies to detect biomarkers, such as AR-V7 from non-invasive blood samples, so-called blood biopsies.

  9. Growth Rate Estimates of Supergene Manganese Nodule by 40Ar/39Ar Isotopic Dating

    Institute of Scientific and Technical Information of China (English)

    Li Jianwei; Vasconcelos P M


    Increasing world-class, high-grade, and metals-enriched supergene manganese ore deposits have been discovered in the last two decades, making them more and more economically important. However, data on the timing and duration of their formation are sparse, mainly due to the difficulties extracting datable minerals suited to traditional radiometric dating methods. Hollandite, cryptomelane, coronadite, todorokite, and manjiroite are common manganese oxide minerals in supergene environments. These minerals host potassium of variable amounts from 0.1 wt% to 5.0 wt% in their structural sites. This geochemical property provides possibility to date supergene manganese ores by using K-Ar and 40Ar/39Ar methods. In this study, we perform 40Ar/39Ar dating on a 7.1-cm-thick botryoidal manganese nodule from an ancient weathering profile at Mount Tabor, central Queensland, Australia. Laser microprobe incremental analyses of distinct growth bands, from the inner core through the intermediate bands to the outermost crusts of the nodule, have yielded high quality 40Ar/39Ar ages at 27.3 Ma, 20.9 Ma, 19.2 Ma, and 16.1 Ma, respectively. The age results permit preliminary estimates on the average growth rates of the nodule varying from 4.7×10-3 mm/ka to 7.6×10-3 mm/ka to 9.0×10-3 mm/ka, from the core to the rim. Results of this study are of significance in our understanding of the mode, mechanism, process, and climatic conditions in the formation of supergene manganese ore deposits.

  10. Regulation of AR Degradation and Function by Ubiquitylation (United States)


    STATEMENT Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT The pathways that normally mediate AR...ligase (CHIP) may mediate the polyubiquitylation and proteasome degradation of AR that fails to fold appropriately and bind ligand. However, there are...pathways that normally mediate the ubiquitin dependent or independent degradation of AR, which might be targeted therapeutically, remain to be

  11. Antarlides: A New Type of Androgen Receptor (AR) Antagonist that Overcomes Resistance to AR-Targeted Therapy. (United States)

    Saito, Shun; Fujimaki, Takahiro; Panbangred, Watanalai; Igarashi, Yasuhiro; Imoto, Masaya


    Prostate cancer is treated with androgen receptor (AR) antagonists but most patients experience disease progression after long-term treatment with these compounds. Therefore, new AR antagonists are required for patient follow-up treatment. In the course of screening for a new AR antagonist, we isolated the novel compounds antarlides A-E (1-5) from Streptomyces sp. BB47. Antarlides are mutually isomeric with respect to the double bond and have a 22-membered-ring macrocyclic structure. The full stereostructure of 1 was established by chemical modifications, including methanolysis, the Trost method, acetonide formation, and the PGME method. 1-5 inhibited the binding of androgen to ARs in vitro. In addition, 2 inhibited the transcriptional activity of not only wild-type AR but also mutant ARs, which are seen in patients with acquired resistance to clinically used AR antagonists. Therefore, antarlides are a potent new generation of AR antagonists that overcome resistance.

  12. Re-measurement of $^{32}$Ar to test the IMME

    CERN Multimedia

    The Isobaric Multiplet Mass Equation (IMME) has been subject to extensive studies in the low-mass region. Especially at the A = 32 quintet, the predicted quadratic form could not be confirmed, possible explanations being the insufficient accuracy of input parameters or higher-order interactions within the nucleon. For this quintet, the uncertainty on the mass-excess values of four of the five T = 2 multiplet members is extremely low: 0.6 keV for $^{32}$Cl, 0.3 keV for $^{32}$S, 0.2 keV for $^{32}$P, and 0.7 keV for $^{32}$Si. In the case of $^{32}$Ar, however, the uncertainty is as large as 1.8 keV. State-of-the-art high-precision Penning-trap mass spectrometry makes it possible to decrease this uncertainty. We propose to remeasure the mass of $^{32}$Ar at the Penning-trap mass spectrometer ISOLTRAP thus decreasing the uncertainty by a factor of 3-5. The proposed measurement is part of an experimental collaboration with JYFLTRAP, where the remaining masses of the T = 2 isospin quintet at A = 32 will be remeas...

  13. Molecular dynamics study of Ar flow and He flow inside carbon nanotube junction as a molecular nozzle and diffuser

    Directory of Open Access Journals (Sweden)

    Itsuo Hanasaki, Akihiro Nakatani and Hiroshi Kitagawa


    Full Text Available A carbon nanotube junction consists of two connected nanotubes with different diameters. It has been extensively investigated as a molecular electronic device since carbon nanotubes can be metallic and semiconductive, depending on their structure. However, a carbon nanotube junction can also be viewed as a nanoscale nozzle andv diffuser. Here, we focus on the nanotube junction from the perspective of an intersection between machine, material and device. We have conducted a molecular dynamics simulation of the molecular flow inside a modeled (12,12–(8,8 nanotube junction. A strong gravitational field and a periodic boundary condition are applied in the flow direction. We investigated dense-Ar flows and dense-He flows while controlling the temperature of the nanotube junction. The results show that Ar atoms tend to be near to the wall and the density of the Ar is higher in the wide (12,12 nanotube than in the narrow (8,8 nanotube, while it is lower in the wide tube when no flow occurs. The streaming velocities of both the Ar and the He are higher in the narrow nanotube than in the wide nanotube, but the velocity of the Ar is higher than the velocity of the He and the temperature of the flowing Ar is higher than the temperature of the He when the same magnitude of gravitational field is applied.

  14. The thermal history of the Lhasa Block, South Tibetan Plateau based on FTD and Ar-Ar dating

    CERN Document Server

    Yang, T F; Lo Chong Huah; Chung, S L; Tien, R L; Xu, R; Deng, W


    Twelve basement samples were collected from South Tibet Plateau for FTD and Ar-Ar analysis to demonstrate their uplifting history since Cenozoic era. The preliminary results from different minerals with different closure temperatures, including apatite and zircon for fission-track dating, and K-feldspar, biotite for Ar-Ar dating, show that at least four stages of thermal history can be recognized in the studied area.

  15. Measuring 36Ar without H35Cl interference (United States)

    Saxton, John


    Noble gas measurements are usually made in static mode, when the mass spectrometer sensitivity is inversely proportional to volume: this makes the building of very large instruments to obtain high mass resolution impracticable. A particularly challenging interference has hitherto been H35Cl, which differs in mass from 36Ar by 1 part in 3937. We have developed a method which makes improved use of the available MRP to remove interferences, and used it to obtain HCl-free 36Ar measurements on a multicollector instrument with MRP of only ~6000 (MRP= mass resolving power = m/dm 5-95% on side of peak). By arranging that the target mass position on a minor isotope (e.g. 36Ar), from which the interference must be removed, coincides with the ~50% point on the side of a major isotope (e.g. 40Ar), it is possible both to set the mass accurately and to verify the mass position and stability during measurements. The peak top of 40Ar is measured in a separate mass step. Two small corrections are necessary. One compensates for the residual HCl tail at the 36Ar position. The other arises because the peak is not totally flat in the region of interest: 40Ar and 36Ar+HCl are measured on the peak top, whilst 36Ar is measured at the extreme edge, with slightly lower efficiency. The required correction parameters can be obtained from a series of air calibrations with different target/interference ratios. With samples containing 4x10-15to 3x10-14moles of 40Ar, 36Ar/40Ar was measured, without HCl interference, to a 1σ precision of 0.5%, only slightly worse than counting statistics. This is potentially useful for 40Ar/39Ar dating, where 36Ar is used to correct for trapped air, and may be particularly significant for smaller or younger samples.

  16. Guidelines, "minimal requirements" and standard of care in glioblastoma around the Mediterranean Area: A report from the AROME (Association of Radiotherapy and Oncology of the Mediterranean arEa) Neuro-Oncology working party. (United States)


    Glioblastoma is the most common and the most lethal primary brain tumor in adults. Although studies are ongoing, the epidemiology of glioblastoma in North Africa (i.e. Morocco, Algeria and Tunisia) remains imperfectly settled and needs to be specified for a better optimization of the neuro-oncology healthcare across the Mediterranean area and in North Africa countries. Over the last years significant therapeutic advances have been accomplished improving survival and quality of life of glioblastoma patients. Indeed, concurrent temozolomide-radiotherapy (temoradiation) and adjuvant temozolomide has been established as the standard of care associated with a survival benefit and a better outcome. Therefore, considering this validated strategy and regarding the means and some other North Africa countries specificities, we decided, under the auspices of AROME (association of radiotherapy and oncology of the Mediterranean area;, a non-profit organization, to organize a dedicated meeting to discuss the standards and elaborate a consensus on the "minimal requirements" adapted to the local resources. Thus, panels of physicians involved in daily multidisciplinary brain tumors management in the two borders of the Mediterranean area have been invited to the AROME neuro-oncology working party. We report here the consensus, established for minimal human and material resources for glioblastoma diagnosis and treatment faced to the standard of care, which should be reached. If the minimal requirements are not reached, the patients should be referred to the closest specialized medical center where at least minimal requirements, or, ideally, the standard of care should be guaranteed to the patients.

  17. Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells.

    Directory of Open Access Journals (Sweden)

    Congcong Chen

    Full Text Available Androgen receptor (AR signaling is crucial to the development and homeostasis of the prostate gland, and its dysregulation mediates common prostate pathologies. The mechanisms whereby AR regulates growth suppression and differentiation of luminal epithelial cells in the prostate gland and proliferation of malignant versions of these cells have been investigated in human and rodent adult prostate. However, the cellular stress response of human prostate epithelial cells is not well understood, though it is central to prostate health and pathology. Here, we report that androgen sensitizes HPr-1AR and RWPE-AR human prostate epithelial cells to cell stress agents and apoptotic cell death. Although 5α-dihydrotestosterone (DHT treatment alone did not induce cell death, co-treatment of HPr-1AR cells with DHT and an apoptosis inducer, such as staurosporine (STS, TNFt, or hydrogen peroxide, synergistically increased cell death in comparison to treatment with each apoptosis inducer by itself. We found that the synergy between DHT and apoptosis inducer led to activation of the intrinsic/mitochondrial apoptotic pathway, which is supported by robust cleavage activation of caspase-9 and caspase-3. Further, the dramatic depolarization of the mitochondrial membrane potential that we observed upon co-treatment with DHT and STS is consistent with increased mitochondrial outer membrane permeabilization (MOMP in the pro-apoptotic mechanism. Interestingly, the synergy between DHT and apoptosis inducer was abolished by AR antagonists and inhibitors of transcription and protein synthesis, suggesting that AR mediates pro-apoptotic synergy through transcriptional regulation of MOMP genes. Expression analysis revealed that pro-apoptotic genes (BCL2L11/BIM and AIFM2 were DHT-induced, whereas pro-survival genes (BCL2L1/BCL-XL and MCL1 were DHT-repressed. Hence, we propose that the net effect of these AR-mediated expression changes shifts the balance of BCL2-family proteins

  18. SEM and ESR measurements on HOPG surfaces irradiated with Ar{sup 11+} and Ar{sup 1+}

    Energy Technology Data Exchange (ETDEWEB)

    Liu Shengjin; Sakurai, Makoto; Zhang Weimin; Asakura, Ken; Iida, Naoyuki; Sakurai, Takahiro; Ohta, Hitoshi [Department of Physics, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501 (Japan); Tona, Masahide [Department of Chemistry, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501 (Japan); Terui, Toshifumi, E-mail: [National Institute of Information and Communications Technology, Iwaoka, Kobe 651-2492 (Japan)


    Highly oriented pyrolytic graphite (HOPG) samples were irradiated with a highly charged ion (HCI) Ar{sup 11+} at a fluence of 10{sup 14} cm{sup -2}. After irradiation, scanning electron microscopy (SEM) was used to observe the irradiated trace. During SEM measurement, an electron acceleration voltage of 0.5, 1 and 5 kV was applied to measure the samples, respectively. The irradiated contrast can be observed in the Si surface at 0.5 kV, which could not be found at 1 kV or higher. The irradiated area becomes brighter than that of the unirradiated area. When Ar{sup 1+} was used to bombard the solid surface, the fluence should become of the order of 10{sup 15} cm{sup -2}. In this case, the irradiated contrast could be observed. It means HCI is able to enhance more effectively the surface modification. Furthermore, electron spin resonance was used to measure the surface of highly oriented pyrolytic graphite (HOPG). A clear resonant peak appears in the irradiated sample, which cannot be found in the pristine sample. The phenomenon could be related to defects induced by the HCI impact.

  19. MEIS1 functions as a potential AR negative regulator

    Energy Technology Data Exchange (ETDEWEB)

    Cui, Liang [Department of Urology, Chinese PLA Medical School/Chinese PLA General Hospital, Beijing 100853 (China); Department of Urology, Civil Aviation General Hospital/Civil Aviation Medical College of Peking University, Beijing 100123 (China); Li, Mingyang [Department of Gastroenterology, Nan Lou Division, Chinese PLA Medical School/Chinese PLA General Hospital, Beijing 100853 (China); Feng, Fan [Department of Pharmacy, General Hospital of Shenyang Military Command, Shenyang 110016 (China); Yang, Yutao [Beijing Institute for Neuroscience, Capital Medical University, Beijing 100069 (China); Hang, Xingyi [National Scientific Data Sharing Platform for Population and Health, Beijing 100730 (China); Cui, Jiajun, E-mail: [Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 (United States); Gao, Jiangping, E-mail: [Department of Urology, Chinese PLA Medical School/Chinese PLA General Hospital, Beijing 100853 (China)


    The androgen receptor (AR) plays critical roles in human prostate carcinoma progression and transformation. However, the activation of AR is regulated by co-regulators. MEIS1 protein, the homeodomain transcription factor, exhibited a decreased level in poor-prognosis prostate tumors. In this study, we investigated a potential interaction between MEIS1 and AR. We found that overexpression of MEIS1 inhibited the AR transcriptional activity and reduced the expression of AR target gene. A potential protein–protein interaction between AR and MEIS1 was identified by the immunoprecipitation and GST pull-down assays. Furthermore, MEIS1 modulated AR cytoplasm/nucleus translocation and the recruitment to androgen response element in prostate specific antigen (PSA) gene promoter sequences. In addition, MEIS1 promoted the recruitment of NCoR and SMRT in the presence of R1881. Finally, MEIS1 inhibited the proliferation and anchor-independent growth of LNCaP cells. Taken together, our data suggests that MEIS1 functions as a novel AR co-repressor. - Highlights: • A potential interaction was identified between MEIS1 and AR signaling. • Overexpression of MEIS1 reduced the expression of AR target gene. • MEIS1 modulated AR cytoplasm/nucleus translocation. • MEIS1 inhibited the proliferation and anchor-independent growth of LNCaP cells.

  20. Stilbene induced inhibition of androgen receptor dimerization: implications for AR and ARΔLBD-signalling in human prostate cancer cells.

    Directory of Open Access Journals (Sweden)

    Wolfgang Streicher

    Full Text Available BACKGROUND: Advanced castration resistant prostate cancer (CRPC is often characterized by an increase of C-terminally truncated, constitutively active androgen receptor (AR variants. Due to the absence of a ligand binding domain located in the AR-C-terminus, these receptor variants (also termed ARΔLBD are unable to respond to all classical forms of endocrine treatments like surgical/chemical castration and/or application of anti-androgens. METHODOLOGY: In this study we tested the effects of the naturally occurring stilbene resveratrol (RSV and (E-4-(2, 6-Difluorostyryl-N, N-dimethylaniline, a fluorinated dialkylaminostilbene (FIDAS on AR- and ARΔLBD in prostate cancer cells. The ability of the compounds to modulate transcriptional activity of AR and the ARΔLBD-variant Q640X was shown by reporter gene assays. Expression of endogenous AR and ARΔLBD mRNA and protein levels were determined by qRT-PCR and Western Blot. Nuclear translocation of AR-molecules was analyzed by fluorescence microscopy. AR and ARΔLBD/Q640X homo-/heterodimer formation was assessed by mammalian two hybrid assays. Biological activity of both compounds in vivo was demonstrated using a chick chorioallantoic membrane xenograft assay. RESULTS: The stilbenes RSV and FIDAS were able to significantly diminish AR and Q640X-signalling. Successful inhibition of the Q640X suggests that RSV and FIDAS are not interfering with the AR-ligand binding domain like all currently available anti-hormonal drugs. Repression of AR and Q640X-signalling by RSV and FIDAS in prostate cancer cells was caused by an inhibition of the AR and/or Q640X-dimerization. Although systemic bioavailability of both stilbenes is very low, both compounds were also able to downregulate tumor growth and AR-signalling in vivo. CONCLUSION: RSV and FIDAS are able to inhibit the dimerization of AR and ARΔLBD molecules suggesting that stilbenes might serve as lead compounds for a novel generation of AR-inhibitors.

  1. Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer.

    LENUS (Irish Health Repository)

    Brennan, Donal J


    BACKGROUND: Our group previously reported that tumour-specific expression of the rate-limiting enzyme in the mevalonate pathway, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) is associated with more favourable tumour parameters and a good prognosis in breast cancer. In the present study, the prognostic value of HMG-CoAR expression was examined in tumours from a cohort of patients with primary epithelial ovarian cancer. METHODS: HMG-CoAR expression was assessed using immunohistochemistry (IHC) on tissue microarrays (TMA) consisting of 76 ovarian cancer cases, analysed using automated algorithms to develop a quantitative scoring model. Kaplan Meier analysis and Cox proportional hazards modelling were used to estimate the risk of recurrence free survival (RFS). RESULTS: Seventy-two tumours were suitable for analysis. Cytoplasmic HMG-CoAR expression was present in 65% (n = 46) of tumours. No relationship was seen between HMG-CoAR and age, histological subtype, grade, disease stage, estrogen receptor or Ki-67 status. Patients with tumours expressing HMG-CoAR had a significantly prolonged RFS (p = 0.012). Multivariate Cox regression analysis revealed that HMG-CoAR expression was an independent predictor of improved RFS (RR = 0.49, 95% CI (0.25-0.93); p = 0.03) when adjusted for established prognostic factors such as residual disease, tumour stage and grade. CONCLUSION: HMG-CoAR expression is an independent predictor of prolonged RFS in primary ovarian cancer. As HMG-CoAR inhibitors, also known as statins, have demonstrated anti-neoplastic effects in vitro, further studies are required to evaluate HMG-CoAR expression as a surrogate marker of response to statin treatment, especially in conjunction with current chemotherapeutic regimens.

  2. Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer

    Directory of Open Access Journals (Sweden)

    Gallagher William M


    Full Text Available Abstract Background Our group previously reported that tumour-specific expression of the rate-limiting enzyme in the mevalonate pathway, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR is associated with more favourable tumour parameters and a good prognosis in breast cancer. In the present study, the prognostic value of HMG-CoAR expression was examined in tumours from a cohort of patients with primary epithelial ovarian cancer. Methods HMG-CoAR expression was assessed using immunohistochemistry (IHC on tissue microarrays (TMA consisting of 76 ovarian cancer cases, analysed using automated algorithms to develop a quantitative scoring model. Kaplan Meier analysis and Cox proportional hazards modelling were used to estimate the risk of recurrence free survival (RFS. Results Seventy-two tumours were suitable for analysis. Cytoplasmic HMG-CoAR expression was present in 65% (n = 46 of tumours. No relationship was seen between HMG-CoAR and age, histological subtype, grade, disease stage, estrogen receptor or Ki-67 status. Patients with tumours expressing HMG-CoAR had a significantly prolonged RFS (p = 0.012. Multivariate Cox regression analysis revealed that HMG-CoAR expression was an independent predictor of improved RFS (RR = 0.49, 95% CI (0.25-0.93; p = 0.03 when adjusted for established prognostic factors such as residual disease, tumour stage and grade. Conclusion HMG-CoAR expression is an independent predictor of prolonged RFS in primary ovarian cancer. As HMG-CoAR inhibitors, also known as statins, have demonstrated anti-neoplastic effects in vitro, further studies are required to evaluate HMG-CoAR expression as a surrogate marker of response to statin treatment, especially in conjunction with current chemotherapeutic regimens.

  3. Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer

    LENUS (Irish Health Repository)

    Brennan, Donal J


    Abstract Background Our group previously reported that tumour-specific expression of the rate-limiting enzyme in the mevalonate pathway, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) is associated with more favourable tumour parameters and a good prognosis in breast cancer. In the present study, the prognostic value of HMG-CoAR expression was examined in tumours from a cohort of patients with primary epithelial ovarian cancer. Methods HMG-CoAR expression was assessed using immunohistochemistry (IHC) on tissue microarrays (TMA) consisting of 76 ovarian cancer cases, analysed using automated algorithms to develop a quantitative scoring model. Kaplan Meier analysis and Cox proportional hazards modelling were used to estimate the risk of recurrence free survival (RFS). Results Seventy-two tumours were suitable for analysis. Cytoplasmic HMG-CoAR expression was present in 65% (n = 46) of tumours. No relationship was seen between HMG-CoAR and age, histological subtype, grade, disease stage, estrogen receptor or Ki-67 status. Patients with tumours expressing HMG-CoAR had a significantly prolonged RFS (p = 0.012). Multivariate Cox regression analysis revealed that HMG-CoAR expression was an independent predictor of improved RFS (RR = 0.49, 95% CI (0.25-0.93); p = 0.03) when adjusted for established prognostic factors such as residual disease, tumour stage and grade. Conclusion HMG-CoAR expression is an independent predictor of prolonged RFS in primary ovarian cancer. As HMG-CoAR inhibitors, also known as statins, have demonstrated anti-neoplastic effects in vitro, further studies are required to evaluate HMG-CoAR expression as a surrogate marker of response to statin treatment, especially in conjunction with current chemotherapeutic regimens.

  4. Excess Ar-40 in the Zagami Shergottite: Does It Reveal Crystallization History? (United States)

    Bogard, Donald D.; Park, Jisun


    The Zagami basaltic shergottite has fine- and coarse-grained (FG & CG) areas, which may reflect partial crystallization in a deep, slowly cooled magma chamber to form Mg-rich pyroxene cores, followed by entrainment of these crystals into a magma that rose and crystallized near the surface. Late-stage melt pockets formed mesostasis and feldspar (maskelynite) having a range of compositions, but low water abundance. Higher I(sub Sr) in the FG portion may result from the second stage having incorporated old crustal rocks that failed to reach isotopic equilibrium. Zagami, like other shergottites, contains excess Ar-40(sub xs) beyond that expected from internal decay of K-40 during its Sm-Nd age of 177 Myr. We suggest that at least a portion of this Ar-40(sub xs) in Zagami and some other shergottites was inherited from the magma, much as is the case of MORBs on Earth. We made Ar-39-Ar-40 age determinations on feldspar and pyroxene separates from both the FG and CG portions of Zagami. If Zagami experienced an evolving fractional crystallization history, including possible crustal contamination of the magma, that might be indicated in differing amounts of Ar-40(sub xs) between mineral phases and between FG and CG portions.

  5. Job Stress, Gene Polymorphism of β2-AR, and Prevalence of Hypertension

    Institute of Scientific and Technical Information of China (English)



    Objective To study the interactive effect of job stress and genetic susceptibility (or gene polymorphism) on hypertension. Methods A cross-sectional epidemioiogical study was conducted in 452 workers from a thermal power plant in China. Extrinsic effort, occupational reward, and over-commitment were measured. Hypertensive patients were defined by three phases of screening, reexamination, and final diagnosis. β2-AR genotypes and allele frequencies at amino acid positions 16 (β2-AR-16:Arg→Gly) and 27(β2-AR-27:Gln→Glu) were identified by PCR-RFLP. Results Job stress was related with the prevalence of hypertension in males (P0.05). Differences in genotypes and allele frequencies of the β2-AR-16 were statistically significant between the hypertension and control groups (P0.05). The prevalence of hypertension was higher in individuals carrying Gly16 allele than in those carrying Arg16 allele of the high job stress group (P<0.01 or 0.05). Conclusion High job stress and polymorphism of β2-AR-16 have an interactive effect on the prevalence of hypertension in male workers.

  6. Effect of O2/Ar Gas Flow Ratios on Properties of Cathodic Vacuum Arc Deposited ZnO Thin Films on Polyethylene Terephthalate Substrate

    Directory of Open Access Journals (Sweden)

    Chien-Wei Huang


    Full Text Available Cathodic vacuum arc deposition (CVAD can obtain a good quality thin film with a low growth temperature and a high deposition rate, thus matching the requirement of film deposition on flexible electronics. This paper reported the room-temperature deposition of zinc oxide (ZnO thin films deposited by CVAD on polyethylene terephthalate (PET substrate. Microstructure, optical, and electrical measurements of the deposited ZnO thin films were investigated with various O2/Ar gas flow ratios from 6 : 1 to 10 : 1. The films showed hexagonal wurtzite crystal structure. With increasing the O2/Ar gas flow ratios, the c-axis (002 oriented intensity decreased. The crystal sizes were around 16.03 nm to 23.42 nm. The average transmittance values in the visible range of all deposited ZnO films were higher than 83% and the calculated band gaps from the absorption data were found to be around 3.1 to 3.2 eV. The resistivity had a minimum value in the 3.65 × 10−3 Ω·cm under the O2/Ar gas flow ratio of 8 : 1. The luminescence mechanisms of the deposited film were also investigated to understand the defect types of room-temperature grown ZnO films.

  7. Enseñar a ser


    García Barreno, Pedro


    El «Informe Delors», cuyo texto fue presentado hace ahora diez años, señala que cualquier proyecto educativo para el siglo XXI debe contemplar dos acciones. «Enseñar a conocer, a hacer, a vivir juntos, a ser», y garantizar el acceso de todos a ello. El siglo que concluyó apenas media docena de años, ha estado cargado de inmensas paradojas: entre grandes males, extraordinarios logros y no pocas esperanzas inalcanzadas. Marcado por dos guerras mundiales, po...

  8. AR Alternative Splicing and Prostate Cancer Progression (United States)


    evolutionary origin and sequence divergence, with relative ages (oldest to youngest) L1M1 > L1MA3 > L1PB2 > L1PREC2 > L1PA7 > L1PA5 (41, 42). Figure...variant of the human AR, which was originally identified via 5 0 rapid amplification of cDNA ends (RACE) with RNA isolated from human placenta tissue...prerequisite for tran- scriptional activation. However, this theory has not been rigor- ously tested. Therefore, we transfected cells with diverse trun

  9. Microanalysis of Ar and He bombarded biomedical polymer films

    Energy Technology Data Exchange (ETDEWEB)

    Manso Silvan, M. [Departamento de Fisica Aplicada C-XII, Universidad Autonoma de Madrid, 28049 Madrid (Spain)]. E-mail:; Gago, R. [Departamento de Fisica Aplicada C-XII, Universidad Autonoma de Madrid, 28049 Madrid (Spain); Centro de Microanalisis de Materiales, Universidad Autonoma de Madrid, 28049 Madrid (Spain); Valsesia, A. [European Commission, Institute for Health and Consumer Protection, Via Enrico Fermi, 21020 Ispra (Italy); Climent Font, A. [Departamento de Fisica Aplicada C-XII, Universidad Autonoma de Madrid, 28049 Madrid (Spain); Centro de Microanalisis de Materiales, Universidad Autonoma de Madrid, 28049 Madrid (Spain); Duart, J.M. Martinez [Departamento de Fisica Aplicada C-XII, Universidad Autonoma de Madrid, 28049 Madrid (Spain); Rossi, F. [European Commission, Institute for Health and Consumer Protection, Via Enrico Fermi, 21020 Ispra (Italy)


    Implantations onto polyethyleneglycol, polycaprolactone and polymethylmethacrylate, carried out with Ar and He ions at 25 and 100 KeV with fluences of 5 x 10{sup 13} cm{sup -2}, have been made with identical ion currents (20 {mu}A) but different sweep areas in order to take into account the effect of the ion flux on the composition and structure of these biopolymers. Vibrational (Fourier transformed infrared spectroscopy), microanalytical (Rutherford backscattering and energy recoil detection) and microscopic techniques (atomic force microscopy) confirm that, even in this low fluence regime, the ion flux effect is responsible of scaled modifications. More interestingly, these techniques indicate that the damage seems to be higher for He. All these factors suggest that He could be preferentially used to engineer biomedical polymers exploiting the tailoring opportunities offered by ion flux effects.

  10. 40Ar/(39)Ar dating of Chemeron Formation strata encompassing the site of hominid KNM-BC 1, Tugen Hills, Kenya. (United States)

    Deino, Alan L; Hill, Andrew


    A fossil hominid temporal bone (KNM-BC 1) from surface exposures at Baringo Paleontological Research Project site BPRP#2 in the Chemeron Formation outcropping in a tributary drainage of the Kapthurin River west of Lake Baringo, Kenya has been attributed to Homo sp. indet. K-feldspar phenocrysts from lapilli tuffs bracketing the inferred fossiliferous horizon yield single-crystal(40)Ar/(39)Ar ages of 2.456+/-0.006 and 2.393+/-0.013 Ma. These age determinations are supported by stratigraphically consistent ages on higher tuff horizons and from nearby sections. In addition, new(40)Ar/(39)Ar ages on tuffaceous units near the base and top of the formation along the Kapthurin River yield 3.19+/-0.03 and 1.60+/-0.05 Ma respectively. The base of the formation along the Kapthurin River is thus approximately 0.5 Ma younger than the uppermost Chemeron Formation strata exposed at Tabarin, 23 km to the north-northwest. The upper half of the formation along the Kapthurin River was deposited at an average rate of approximately 11 cm/ka, compared to 21-23 cm/ka at Tabarin.

  11. 40Ar/39Ar geochronology and geochemical reconnaissance of the Eocene Lowland Creek volcanic field, west-central Montana (United States)

    Dudas, F.O.; Ispolatov, V.O.; Harlan, S.S.; Snee, L.W.


    We report geochronological and geochemical data for the calc-alkalic Lowland Creek volcanic field (LCVF) in westcentral Montana. 40Ar/ 39Ar age determinations show that the LCVF was active from 52.9 to 48.6 Ma, with tuff-forming eruptions at 52.9 ?? 0.14 and 51.8 ?? 0.14 Ma. These dates span the age range of vigorous Eocene igneous activity in the Kamloops-Absaroka-Challis belt. The LCVF evolved upward from basal rhyolites (SiO 2>71 wt%) to dacites and andesites (SiO 2 > 62 wt%). Compositional change parallels a transition from early explosive volcanism to late effusive activity. Four geochemical components can be detected in the rocks. A component with 206Pb/204Pb nd epsilon;Nd near-15 is predominant in anhydrous, two-pyroxene dacites; hydrous rhyolites, rhyodacites, and dacites with epsilon;Nd below-10 are dominated by a second component; hydrous rocks with 206Pb/ 204Pb > 18.3 and epsilon;Nd>-9 contain a third component; and an andesite with low Nd content and epsilon;Nd near-9 probably contains a fourth component. The first three components probably derive from the lower and middle crust, whereas the fourth is probably from the lithospheric mantle. ?? 2010 by The University of Chicago.

  12. Complete Genome Sequence of Mayaro Virus (Togaviridae, Alphavirus) Strain BeAr 20290 from Brazil


    Espósito, Danillo Lucas Alves; da Fonseca, Benedito Antônio Lopes


    We report here the complete genome sequence of Mayaro virus strain BeAr 20290 isolated from Haemagogus mosquitoes in 1960. The sequence presented here includes all nonstructural and structural proteins and the 5′- and 3′-untranslated (UTR) regions.

  13. Multiple Electron Capture Processes in Slow Collisions of Ar9+ Ions with Na Atoms

    Institute of Scientific and Technical Information of China (English)

    ZhuXiaolong; ShaShan; LiuHuiping; WeiBaoren; MaXinwen; WangZhengling; CaoShiping; QianDongbing; YangZhihu


    Slow collisions of highly charged ions with neutral atoms and molecules are of great importance in basic atomic collision physics, Recently, we built a new research facility for atomic physics at the Institute of Modern Physics. We report here the multiple electron transfer processes in collisions of Ar9+ with Na gas target at energy of 180 keV.

  14. Comments on arXiv:1011.3046 "Muon Capture Constraints on Sterile Neutrino Properties"

    CERN Document Server

    Gninenko, S N


    It has been very recently reported (McKeen, Pospelov, arXive:1011.3046) that the parameter region suggested for an explanation of the neutrino oscillation results from the LSND, KARMEN and MiniBooNE experiments in terms of the production and radiative decay of a heavy neutrino ($\

  15. The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis. (United States)

    Castillo, Ana F; Orlando, Ulises; Helfenberger, Katia E; Poderoso, Cecilia; Podesta, Ernesto J


    The steroidogenic acute regulatory (StAR) protein regulates the rate-limiting step in steroidogenesis, i.e. the delivery of cholesterol from the outer (OMM) to the inner (IMM) mitochondrial membrane. StAR is a 37-kDa protein with an N-terminal mitochondrial targeting sequence that is cleaved off during mitochondrial import to yield 30-kDa intramitochondrial StAR. StAR acts exclusively on the OMM and its activity is proportional to how long it remains on the OMM. However, the precise fashion and the molecular mechanism in which StAR remains on the OMM have not been elucidated yet. In this work we will discuss the role of mitochondrial fusion and StAR phosphorylation by the extracellular signal-regulated kinases 1/2 (ERK1/2) as part of the mechanism that regulates StAR retention on the OMM and activity.

  16. Quadrupole Collectivity beyond N=28: Intermediate-Energy Coulomb Excitation of Ar47,48 (United States)

    Winkler, R.; Gade, A.; Baugher, T.; Bazin, D.; Brown, B. A.; Glasmacher, T.; Grinyer, G. F.; Meharchand, R.; McDaniel, S.; Ratkiewicz, A.; Weisshaar, D.


    We report on the first experimental study of quadrupole collectivity in the very neutron-rich nuclei Ar47,48 using intermediate-energy Coulomb excitation. These nuclei are located along the path from doubly magic Ca to collective S and Si isotopes, a critical region of shell evolution and structural change. The deduced B(E2) transition strengths are confronted with large-scale shell-model calculations in the sdpf shell using the state-of-the-art SDPF-Uand EPQQM effective interactions. The comparison between experiment and theory indicates that a shell-model description of Ar isotopes around N=28 remains a challenge.

  17. Melt-inclusion-hosted excess 40Ar in quartz crystals of the Bishop and Bandelier magma systems (United States)

    Winick, J.A.; McIntosh, W.C.; Dunbar, N.W.


    40Ar/39Ar experiments on melt-inclusion-bearing quartz (MIBQ) from the Bishop and Bandelier Tuff Plinian deposits indicate high concentrations of excess 40Ar in melt inclusions. Two rhyolite glass melt inclusion populations are present in quartz; exposed melt inclusions and trapped melt inclusions. Air-abrasion mill grinding and hydrofluoric acid treatments progressively remove exposed melt inclusions while leaving trapped melt inclusions unaffected. Laser step-heating of MIBQ yields increasing apparent ages as a function of exposed melt inclusion removal, reflecting the higher nonatmospheric 40Ar concentrations hosted in trapped melt inclusions. Exposed melt inclusion-free MIBQ from the Bishop, Upper Bandelier, and Lower Bandelier Tufts yield total-gas ages of 3.70 ?? 1.00 Ma, 11.54 ?? 0.87 Ma, and 14.60 ?? 1.50 Ma, respectively. We interpret these old apparent ages as compelling evidence for the presence of excess 40Ar in MIBQ. Trapped melt inclusions in sanidine phenocrysts may contain excess 40Ar concentrations similar to those in MIBQ. This excess 40Ar has the potential to increase single-crystal laser-fusion ages of sanidine by tens of thousands of years, relative to the actual eruption age.

  18. Seasonal changes and sexual dimorphism in gene expression of StAR protein, steroidogenic enzymes and sex hormone receptors in the frog brain. (United States)

    Santillo, Alessandra; Falvo, Sara; Di Fiore, Maria Maddalena; Chieffi Baccari, Gabriella


    The brain of amphibians contains all the key enzymes of steroidogenesis and has a high steroidogenic activity. In seasonally-breeding amphibian species brain steroid levels fluctuate synchronously with the reproductive cycle. Here we report a study of gene expression of StAR protein, key steroidogenic enzymes and sex hormone receptors in the telencephalon (T) and diencephalon-mesencephalon (D-M) of male and female reproductive and post-reproductive Pelophylax esculentus, a seasonally breeding anuran amphibian. Significant differences in gene expression were observed between (a) the reproductive and post-reproductive phase, (b) the two brain regions and (c) male and female frogs. During the reproductive phase, star gene expression increased in the male (both T and D-M) but not in the female brain. Seasonal fluctuations in expression levels of hsd3b1, hsd17b1, srd5a1 and cyp19a1 genes for neurosteroidogenic enzymes occurred in D-M region of both sexes, with the higher levels in reproductive period. Moreover, the D-M region generally showed higher levels of gene expression than the T region in both sexes. Gene expression was higher in females than males for most genes, suggesting higher neurosteroid production in female brain. Seasonal and sex-linked changes were also observed in gene expression for androgen (ar) and estrogen (esr1, esr2) receptors, with the males showing the highest ar levels in reproductive phase and the highest esr1 and esr2 levels in post-reproductive phase; in contrast, females showed the maximum expression for all three genes in reproductive phase. The results are the first evidence for seasonal changes and sexual dimorphism of gene expression of the neurosteroidogenic pathway in amphibians.

  19. [Concordance between self-reported weight and height for nutritional assessment in adults aged between 25 and 50 years without higher education]. (United States)

    Matínez-Torres, Javier; Lee Osorno, Belinda Inés; Mendoza, Leylis; Mariotta, Sharom; López Epiayu, Yandra; Martínez, Yelitza; Jiménez, Nelly


    Overweight and obesity are metabolic disorders that have become a public health problem due to the current high prevalence; therefore, it is important to create simple monitoring systems to assess their trends. To determine the correlation between weight, height and body mass index reported by patients and the values measured directly in adults between 25 and 50 years old without higher education. A cross-sectional descriptive study was conducted with participation of 207 adults between 25 and 50 years old. Each participant was asked weight and height; and body mass index was calculated with these data. Moreover, a qualified person determined the real value of these variables. The coefficient of intra-class correlation between self-reported and measurements was obtained. The body mass index measured for men was 25.8±3.7 kg/m2 and for women 26.0±4.1 kg/m2. Intraclass correlation coefficients were for weight 0.962 (IC95%: 0.950-0.971), height 0.909 (IC95%: 0.882-0.930), and body mass index 0.929 (IC95% 0.907-0.945); the real prevalence of people with a body mass index greater than 25 kg/m2 was 52.1%, whereas the value obtained by self-reported data was 44%. Self-reported weight and height data are useful for obesity assessment in adults aged between 25 and 50 years without higher education at the population level. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  20. Characterization of 41Ar production in air at a PET cyclotron facility (United States)

    Cicoria, Gianfranco; Cesarini, Francesco; Infantino, Angelo; Vichi, Sara; Zagni, Federico; Marengo, Mario


    In the production of Positron Emission Tomography (PET) nuclides at a medical cyclotron facility 41Ar (T1/2 = 109.34 m) is produced by the activation of air due to the neutron flux, according to the 40Ar(n, γ)41Ar reaction. In this work, we describe a relatively inexpensive and readily reproducible methodology of air sampling that can be used for quantification of 41Ar during the routine production of PET nuclides. We report the results of an extensive measurement campaign in the cyclotron bunker and in the ducts of the ventilation system, before and after final filtering of the extracted air. Air Samples were analyzed using a gamma-ray spectrometry system equipped with HPGe detector, with proper correction of the efficiency calibration to account for the samples density. The results of measurement were then used to evaluate the Total Effective Dose (TED) to the population living in the surrounding areas, due to routine emissions in the operation of the cyclotron. The average 41Ar saturation yield per one liter of air emitted in the environment resulted to be (0.044 ± 0.007) Bq/(μA ṡ dm3). The maximum value of TED for the critical group of the population, even considering an overestimated workload, was less than 0.19 μSv/year, well below the level of radiological relevance.

  1. Polarimetric evidence of a white dwarf pulsar in the binary system AR Scorpii (United States)

    Buckley, D. A. H.; Meintjes, P. J.; Potter, S. B.; Marsh, T. R.; Gänsicke, B. T.


    The variable star AR Scorpii (AR Sco) was recently discovered to pulse in brightness every 1.97 min from ultraviolet wavelengths into the radio regime. The system is composed of a cool, low-mass star in a tight, 3.55-hour orbit with a more massive white dwarf. Here we report new optical observations of AR Sco that show strong linear polarization (up to 40%) that varies strongly and periodically on both the spin period of the white dwarf and the beat period between the spin and orbital period, as well as low-level (up to a few per cent) circular polarization. These observations support the notion that, similar to neutron-star pulsars, the pulsed luminosity of AR Sco is powered by the spin-down of the rapidly rotating white dwarf that is highly magnetized (up to 500 MG). The morphology of the modulated linear polarization is similar to that seen in the Crab pulsar, albeit with a more complex waveform owing to the presence of two periodic signals of similar frequency. Magnetic interactions between the two component stars, coupled with synchrotron radiation from the white dwarf, power the observed polarized and non-polarized emission. AR Sco is therefore the first example of a white dwarf pulsar.

  2. Time-resolved rotational spectroscopy of para-difluorobenzene·Ar (United States)

    Weichert, A.; Riehn, C.; Matylitsky, V. V.; Jarzeba, W.; Brutschy, B.


    We report on time-resolved rotational spectroscopy experiments of the cluster para-difluorobenzene·Ar ( pDFB·Ar) by picosecond laser pulses in a supersonic expansion. Rotational coherences of pDFB·Ar are generated by resonant electronic excitation and probed by time-resolved fluorescence depletion spectroscopy and time-resolved photoionization ((1+1') PPI) spectroscopy. The former allows the determination of both ground and excited state rotational constants, whereas the latter technique enables the separate study of the excited state with the benefit of mass-selective detection. Since pDFB·Ar represents a near symmetric oblate rotor, persistent J-type transients with tJ≈ n/2( A+ B) could be measured. From their analysis, (A″+B″)=2234.9±2 MHz and (A'+B')=2237.9±2 MHz were obtained. A structural investigation, based on data of the pDFB monomer, is presented resulting in a pDFB·Ar center-of-mass distance of both moieties of R z=3.543±0.017 Å with a change of ΔR z=-0.057±0.009 Å upon electronic excitation. These results are compared to data of former frequency-resolved experiments and ab initio computations.

  3. Learning Science Using AR Book: A Preliminary Study on Visual Needs of Deaf Learners (United States)

    Megat Mohd. Zainuddin, Norziha; Badioze Zaman, Halimah; Ahmad, Azlina

    Augmented Reality (AR) is a technology that is projected to have more significant role in teaching and learning, particularly in visualising abstract concepts in the learning process. AR is a technology is based on visually oriented technique. Thus, it is suitable for deaf learners since they are generally classified as visual learners. Realising the importance of visual learning style for deaf learners in learning Science, this paper reports on a preliminary study of on an ongoing research on problems faced by deaf learners in learning the topic on Microorganisms. Being visual learners, they have problems with current text books that are more text-based that graphic based. In this preliminary study, a qualitative approach using the ethnographic observational technique was used so that interaction with three deaf learners who are participants throughout this study (they are also involved actively in the design and development of the AR Book). An interview with their teacher and doctor were also conducted to identify their learning and medical problems respectively. Preliminary findings have confirmed the need to design and develop a special Augmented Reality Book called AR-Science for Deaf Learners (AR-SiD).

  4. Role of the two component signal transduction system CpxAR in conferring cefepime and chloramphenicol resistance in Klebsiella pneumoniae NTUH-K2044.

    Directory of Open Access Journals (Sweden)

    Vijaya Bharathi Srinivasan

    Full Text Available BACKGROUND: Klebsiella pneumoniae is a gram-negative, non-motile, facultative anaerobe belonging to the Enterobacteriaceae family of the γ-Proteobacteria class in the phylum Proteobacteria. Multidrug resistant K. pneumoniae have caused major therapeutic problems worldwide due to emergence of extended-spectrum β-lactamase producing strains. Two-component systems serve as a basic stimulus-response coupling mechanism to allow organisms to sense and respond to changes in many different environmental conditions including antibiotic stress. PRINCIPAL FINDINGS: In the present study, we investigated the role of an uncharacterized cpxAR operon in bacterial physiology and antimicrobial resistance by generating isogenic mutant (ΔcpxAR deficient in the CpxA/CpxR component derived from the hyper mucoidal K1 strain K. pneumoniae NTUH-K2044. The behaviour of ΔcpxAR was determined under hostile conditions, reproducing stresses encountered in the gastrointestinal environment and deletion resulted in higher sensitivity to bile, osmotic and acid stresses. The ΔcpxAR was more susceptible to β-lactams and chloramphenicol than the wild-type strain, and complementation restored the altered phenotypes. The relative change in expression of acrB, acrD, eefB efflux genes were decreased in cpxAR mutant as evidenced by qRT-PCR. Comparison of outer membrane protein profiles indicated a conspicuous difference in the knock out background. Gel shift assays demonstrated direct binding of CpxR(KP to promoter region of ompC(KP in a concentration dependent manner. CONCLUSIONS AND SIGNIFICANCE: The Cpx envelope stress response system is known to be activated by alterations in pH, membrane composition and misfolded proteins, and this systematic investigation reveals its direct involvement in conferring antimicrobial resistance against clinically significant antibiotics for the very first time. Overall results displayed in this report reflect the pleiotropic role of the CpxAR

  5. Faster self-reported speed of eating is related to higher body mass index in a nationwide survey of middle-aged women. (United States)

    Leong, Sook Ling; Madden, Clara; Gray, Andrew; Waters, Debra; Horwath, Caroline


    This study is the first nationwide population survey to explore the association between speed of eating and degree of obesity. The objective was to cross-sectionally examine the relationship between self-reported speed of eating and body mass index (BMI; calculated as kg/m(2)) in a nationally representative sample of New Zealand women. In May 2009, a sample of 2,500 New Zealand women aged 40 to 50 years was randomly selected from the nationwide electoral rolls. A 66% participation rate was achieved. Potential participants were mailed a self-administered questionnaire containing questions on self-reported speed of eating, demographics, health conditions, menopause status, physical activity, height, and weight. Univariate models were used to examine the associations between demographic, health and behavioral variables, and BMI, while a multivariate model was developed to investigate the relationship between self-reported speed of eating and BMI. After adjusting for age, smoking status, menopause status, thyroid condition, ethnicity, socioeconomic status, and physical activity, BMI statistically significantly increased by 2.8% (95% confidence interval: 1.5% to 4.1%; P<0.001) for each category increase in self-reported speed of eating. Although the direction of causality requires confirmation in longitudinal and randomized intervention studies, the results suggest that faster eating is associated with higher BMI in middle-aged women.

  6. The activation of the Sox2 RR2 pluripotency transcriptional reporter in human breast cancer cell lines is dynamic and labels cells with higher tumorigenic potential

    Directory of Open Access Journals (Sweden)

    Juan Manuel eIglesias


    Full Text Available The striking similarity displayed at the mechanistic level between tumorigenesis and the generation of induced pluripotent stem cells and the fact that genes and pathways relevant for embryonic development are reactivated during tumor progression highlights the link between pluripotency and cancer. Based on these observations we tested whether it is possible to use a pluripotency-associated transcriptional reporter, whose activation is driven by the SRR2 enhancer from the Sox2 gene promoter (named S4+ reporter, to isolate cancer stem cells from breast cancer cell lines. The S4+ pluripotency transcriptional reporter allows the isolation of cells with enhanced tumorigenic potential and its activation was switched on and off in the cell lines studied, reflecting a plastic cellular process. Microarray analysis comparing the populations in which the reporter construct is active vs. inactive showed that positive cells expressed higher mRNA levels of cytokines (IL-8, IL-6, TNF and genes (such as ATF3, SNAI2, KLF6 previously related with the cancer stem cell phenotype in breast cancer.

  7. Analysis of Ar line spectra from indirectly-driven implosion experiments on SGII facility

    Institute of Scientific and Technical Information of China (English)

    Pu Yu-Dong; Zhang Ji-Yan; Yang Jia-Min; Huang Tian-Xuan; Ding Yong-Kun


    This paper reports on the indirectly-driven implosion experiments on SGII laser facility in which Ar emission spectrum from Ar-doped D-filled plastic capsule is recorded with the crystal spectrometer. Spectral features of Ar Heβ line and its associated satellites are analysed to extract the electron temperature and density of the implosion core. Non local thermal equilibrium (NLTE) collisional-radiative atomic kinetics and Strark broadening line shape are included in the present calculation. By comparing the calculated spectrum with the measured one, the core electron temperature and density are inferred to be 700 eV and 2.5 × 1023 cm-3 respectively. With these inferred values of electron temperature and density, neutron yield can be estimated to agree with the measured value in magnitude despite of the very simple model used for the estimation.

  8. Adsorption of Ar on planar surfaces studied with a density functional theory (United States)

    Sartarelli, Salvador A.; Szybisz, Leszek


    The adsorption of Ar on planar structureless substrates of alkali metals, alkaline-earth metal Mg, CO2 , and Au was analyzed by applying a density functional formalism which includes a recently proposed effective attractive pair potential conditioned to Ar. It is shown that this approach reproduces the experimental surface tension of the liquid-vapor interface over the entire bulk coexistence curve for temperatures T spanning from the triple point Tt up to the critical point Tc . The wetting properties were studied over the entire range temperatures Tt↔Tc . It was found that Ar wets all the investigated surfaces. The adsorption isotherms for alkali metals exhibit first-order phase transitions. Prewetting lines were resolved even for the less attractive surfaces. In the cases of Mg, CO2 , and Au a continuous growth for T≥Tt was obtained. A comparison with experimental data and other microscopic calculations is reported.

  9. Identification of an AR mutation-negative class of androgen insensitivity by determining endogenous AR activity

    NARCIS (Netherlands)

    Hornig, N.C.; Ukat, M.; H.U. Schweikert (H.); O. Hiort (Olaf); Werner, R.; S.L.S. Drop (Stenvert); M.L. Cools (Martine); I.A. Hughes (Ieuan A.); L. Audí (Laura); S.F. Ahmed (S. Faisal); Demiri, J.; Rodens, P.; Worch, L.; Wehner, G.; Kulle, A.E.; Dunstheimer, D.; Müller-Roßberg, E.; T. Reinehr (Thomas); Hadidi, A.T.; Eckstein, A.K.; Van Der Horst, C.; Seif, C.; R. Siebert (Reiner); O. Ammerpohl (Ole); P-M. Holterhus (Paul-Martin)


    textabstractContext: Only approximately 85%of patients with a clinical diagnosis complete androgen insensitivity syndrome and less than 30%with partial androgen insensitivity syndrome can be explained by inactivating mutations in the androgen receptor (AR) gene. Objective: The objective of the study

  10. Pre-Himalayan tectono-magmatic imprints in the Darjeeling-Sikkim Himalaya (DSH) constrained by 40Ar/39Ar dating of muscovite (United States)

    Acharyya, Subhrangsu K.; Ghosh, Subhajit; Mandal, Nibir; Bose, Santanu; Pande, Kanchan


    The Lower Lesser Himalayan Sequence (L-LHS) in Darjeeling-Sikkim Himalaya (DSH) displays intensely deformed, low-grade meta-sedimentary rocks, frequently intervened by granite intrusives of varied scales. The principal motivation of our present study is to constrain the timing of this granitic event. Using 40Ar/39Ar geochronology, we dated muscovite from pegmatites emplaced along the earliest fabric in the low grade Daling phyllite, and obtained ∼1850 Ma Ar-Ar muscovite cooling age, which is broadly coeval with crystallization ages of Lingtse granite protolith (e.g., 1800-1850 Ma U-Pb zircon ages) reported from the L-LHS. We present here field observations to show the imprints (tectonic fabrics) of multiple ductile deformation episodes in the LHS terrain. The earliest penetrative fabric, axial planar to N-S trending reclined folds, suggest a regional tectonic event in the DSH prior to the active phase of Indo-Asia collision. Based on the age of granitic bodies and their structural correlation with the earliest fabric, we propose that the L-LHS as a distinct convergent tectono-magmatic belt, delineating the northern margin of Indian craton in the framework of the ∼1850 Ma Columbia supercontinent assembly.

  11. Emission and absorption spectroscopy study of Ar excited states in 13.56 MHz argon plasma operating at sub-atmospheric to atmospheric pressure

    Energy Technology Data Exchange (ETDEWEB)

    Li, L. [Department of Applied Physics, Research Unit Plasma Technology, Ghent University, Jozef Plateaustraat 22, Ghent B-9000 (Belgium); Nikiforov, A., E-mail: [Department of Applied Physics, Research Unit Plasma Technology, Ghent University, Jozef Plateaustraat 22, Ghent B-9000 (Belgium); Institute of Solution Chemistry of the Russian Academy of Science, Academicheskaya St., 1, Ivanovo, 153045 (Russian Federation); Britun, N. [Chimie des Interactions Plasma-Surface (ChIPS), CIRMAP, Universite de Mons, 23 Place du Parc, B-7000 Mons (Belgium); Snyders, R. [Chimie des Interactions Plasma-Surface (ChIPS), CIRMAP, Universite de Mons, 23 Place du Parc, B-7000 Mons (Belgium); Materia Nova Research Centre, Parc Initialis, B-7000 Mons (Belgium); Leys, C. [Department of Applied Physics, Research Unit Plasma Technology, Ghent University, Jozef Plateaustraat 22, Ghent B-9000 (Belgium)


    The densities of metastable and resonant states of Ar atoms are measured in high pressure Ar radio frequency discharge. Resonant absorption spectroscopy for the case of a low pressure spectral lamp and high-pressure plasma absorption lines is implemented for this purpose. The necessary generalizations for the high-pressure resonant absorption method are given. Absolute density of Ar 1s levels obtained at different RF input power and operating pressures are of the order of 10{sup 11} cm{sup −3}, which is in a good agreement with those reported in the literature. The population distribution on the Ar 2p (excited) levels, obtained from the optical emission spectroscopy, reveals strong deviation from thermal equilibrium for these levels in the high-pressure case. The generation of the Ar excited states in the studied discharges is compared to the previously reported results. - Highlights: • Strong non-equilibrium distribution of Ar 2p levels is observed. • The absolute number density of non-radiative Ar 1s states is determined by the easier and low cost spectral-lamp absorption method. • The modified absorption theory of Mitchell and Zemanski was used to obtain the absolute number density of Ar 1s states at high pressure. • The developed RF source with 5 cm long gap can be a possible alternative to micro-plasma working in Ar at atmospheric pressure.

  12. Observation of a periodic runaway in the reactive Ar/O{sub 2} high power impulse magnetron sputtering discharge

    Energy Technology Data Exchange (ETDEWEB)

    Shayestehaminzadeh, Seyedmohammad, E-mail:, E-mail:; Arnalds, Unnar B.; Magnusson, Rögnvaldur L.; Olafsson, Sveinn [Science Institute, University of Iceland, Dunhaga 3, IS-107 Reykjavik (Iceland)


    This paper reports the observation of a periodic runaway of plasma to a higher density for the reactive discharge of the target material (Ti) with moderate sputter yield. Variable emission of secondary electrons, for the alternating transition of the target from metal mode to oxide mode, is understood to be the main reason for the runaway occurring periodically. Increasing the pulsing frequency can bring the target back to a metal (or suboxide) mode, and eliminate the periodic transition of the target. Therefore, a pulsing frequency interval is defined for the reactive Ar/O{sub 2} discharge in order to sustain the plasma in a runaway-free mode without exceeding the maximum power that the magnetron can tolerate.

  13. A Model of White Dwarf Pulsar AR Scorpii

    CERN Document Server

    Geng, Jin-Jun; Huang, Yong-Feng


    A 3.56-hour white dwarf (WD) - M dwarf (MD) close binary system, AR Scorpii, was recently reported to show pulsating emission in radio, IR, optical, and UV, with a 1.97-minute period, which suggests the existence of a WD with a rotation period of 1.95 minutes. We propose a model to explain the temporal and spectral characteristics of the system. The WD is a nearly perpendicular rotator, with both open field line beams sweeping the MD stellar wind periodically. A bow shock propagating into the stellar wind accelerates electrons in the wind. Synchrotron radiation of these shocked electrons can naturally account for the broad-band (from radio to X-rays) spectral energy distribution of the system.

  14. Effect of water vapor on plasma morphology, OH and H2O2 production in He and Ar atmospheric pressure dielectric barrier discharges (United States)

    Du, Yanjun; Nayak, Gaurav; Oinuma, Gaku; Peng, Zhimin; Bruggeman, Peter J.


    Although atmospheric pressure dielectric barrier discharges (DBDs) have a long history, the effects of water vapor on the discharge morphology and kinetics have not been studied intensively. We report a simultaneous investigation of discharge morphology, OH and H2O2 production in Ar and He DBDs operated at different water vapor concentrations and powers. The combined study allows us to assess the impact of the discharge morphology and power on the concentration dependence of the OH and H2O2 production. The morphology of the discharge is investigated by ICCD images and current–voltage waveforms. These diagnostics are complemented by broadband absorption and a colorimetric method to measure the gas temperature and the OH and H2O2 concentrations. The number of filaments in Ar DBD increases with increasing water concentration and power. The surface discharge part of the micro-discharge also reduces with increasing water concentration most likely due to a change in surface conductivity of the dielectric with changing water concentration. The OH density in the case of Ar is approximately double the OH density in He for similar power and water admixture. In contrast to the root square dependence of the OH density on the water concentration in He similar to diffuse RF discharges, the OH density in Ar increases for small water concentrations followed by a saturation and reduces for higher water concentrations. This dependence of OH density on water concentration is found to correlate with changes in discharge morphology. An analytical balance of the production and destruction mechanism of H2O2 is shown to be able to reproduce the ratio of the measured OH and H2O2 density for realistic values of electron densities.

  15. 40Ar/39Ar Ages for the Sentinel-Arlington Volcanic Field, Southwestern Arizona (United States)

    Cave, S. R.; Greeley, R.; Champion, D. E.; Turrin, B. D.


    The Sentinel Plains lava field and proximate small (history as well as the timing of the ancient Gila River interactions that led to the development of the Painted Rock transverse drainage. The absolute timing was determined in order datermine causal relationships with local tectonism. The SAVF basal contact is ~30 m above the Holocene surface where exposed along the current river channel; and the lavas show similar amounts mantling by aeolian dust, development of pedogenic calcium carbonate, and subsequent incision by radial ephemeral drainages. Relative timing of eruptive events was determined by stratigraphic and embayment relationships. Continuity of distal flows exposed in cross-sections to their source vents could be established using field work, and confirmed using geomagnetic secular variation and geochemical analyses. Edifices generally corresponded to discreet geomagnetic inclination, declination, and paleointensity values. Older eruptive events exhibited normal polarity, while stratigraphically younger events exhibited reversed polarity. Most lavas were alkali olivine basalt with a range of unnormalized SiO2 weight percentages ranging from 47.16-51.48. Geochronology using 40Ar/39Ar method revealed an age of 1.94 +/- 0.85 Ma for Painted Rock Low Shield (New Mexico Geochronology Research Laboratory), 1.64 +/- 0.14 Ma for Theba Low Shield (Rutgers University) and 1.24 +/- 0.040 Ma for Wild Horse Low Shield (Rutgers University). Some ages were precise enough to correspond to the Matuyama reversed polarity epoch, with SAVF initiation possibly within the Olduvai normal polarity event. These dates represent an overall improvement in precision and accuracy over previous dates (values corresponding to 6.20 Ma to 1.28 Ma) collected in the late 1970s and early 1980s using K-Ar technique. The 40Ar/39Ar ages correspond to expected magnetic polarities and stratigraphic sequences.

  16. New palynology-based astronomical and revised 40Ar/39Ar ages for the Eocene maar lake of Messel (Germany) (United States)

    Lenz, Olaf K.; Wilde, Volker; Mertz, Dieter F.; Riegel, Walter


    The annually laminated oil shale from the Eocene maar lake at Messel (Federal State of Hessen, Germany) provides unique paleoenvironmental data for a time interval of ~640 ka during the Paleogene greenhouse phase. As a consequence of orbitally controlled changes in the vegetation in the vicinity of the lake, the lacustrine laminites can now be astronomically tuned. Dating is based on the short eccentricity amplitude modulations of the regional pollen rain and their correlation to the astronomical La2010a/La2010d solutions in combination with a revised 40Ar/39Ar age of a basalt fragment from a lapilli tuff section below the first lacustrine sediments. Depending on different newly suggested ages for the Fish Canyon sanidine used as monitor for neutron irradiation, the age for the eruption at Messel is between 48.27 ± 0.22 and 48.11 ± 0.22 Ma. This allows for the first time the exact correlation of a Paleogene lacustrine sequence to the marine record in Central Europe. The Messel oil shale becomes now slightly older than previously assumed and includes the Ypresian/Lutetian boundary that moves the base of the European Land Mammal Age Geiseltalian (MP 11) into the Lower Eocene. This opens a window for establishing an independent chronostratigraphic framework for Paleogene terrestrial records and their correlation to the marine realm. Furthermore, the study reveals that higher amounts of pollen from "wet" and thermophilous plants indicate less seasonal and more balanced precipitation and slightly higher temperatures during a well-expressed eccentricity minimum.

  17. 75 FR 49005 - In the Matter of Geotec, Inc., InnoPet Brands Corp., Marbledge Group, Inc. (n/k/a AR Growth... (United States)


    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION In the Matter of Geotec, Inc., InnoPet Brands Corp., Marbledge Group, Inc. (n/k/a AR Growth.../a AR Growth Finance Corp.) because it has not filed any periodic reports since the period ended...

  18. Androgen Receptor-Mediated Growth Suppression of HPr-1AR and PC3-Lenti-AR Prostate Epithelial Cells.

    Directory of Open Access Journals (Sweden)

    Young-Chae Kim

    Full Text Available The androgen receptor (AR mediates the developmental, physiologic, and pathologic effects of androgens including 5α-dihydrotestosterone (DHT. However, the mechanisms whereby AR regulates growth suppression and differentiation of luminal epithelial cells in the prostate gland and proliferation of malignant versions of these cells are not well understood, though they are central to prostate development, homeostasis, and neoplasia. Here, we identify androgen-responsive genes that restrain cell cycle progression and proliferation of human prostate epithelial cell lines (HPr-1AR and PC3-Lenti-AR, and we investigate the mechanisms through which AR regulates their expression. DHT inhibited proliferation of HPr-1AR and PC3-Lenti-AR, and cell cycle analysis revealed a prolonged G1 interval. In the cell cycle, the G1/S-phase transition is initiated by the activity of cyclin D and cyclin-dependent kinase (CDK complexes, which relieve growth suppression. In HPr-1AR, cyclin D1/2 and CDK4/6 mRNAs were androgen-repressed, whereas CDK inhibitor, CDKN1A, mRNA was androgen-induced. The regulation of these transcripts was AR-dependent, and involved multiple mechanisms. Similar AR-mediated down-regulation of CDK4/6 mRNAs and up-regulation of CDKN1A mRNA occurred in PC3-Lenti-AR. Further, CDK4/6 overexpression suppressed DHT-inhibited cell cycle progression and proliferation of HPr-1AR and PC3-Lenti-AR, whereas CDKN1A overexpression induced cell cycle arrest. We therefore propose that AR-mediated growth suppression of HPr-1AR involves cyclin D1 mRNA decay, transcriptional repression of cyclin D2 and CDK4/6, and transcriptional activation of CDKN1A, which serve to decrease CDK4/6 activity. AR-mediated inhibition of PC3-Lenti-AR proliferation occurs through a similar mechanism, albeit without down-regulation of cyclin D. Our findings provide insight into AR-mediated regulation of prostate epithelial cell proliferation.

  19. Effects of hydrogen-damaged layer on tin-doped indium oxide etching by H2/Ar plasma (United States)

    Hirata, Akiko; Fukasawa, Masanaga; Shigetoshi, Takushi; Okamoto, Masaki; Nagahata, Kazunori; Li, Hu; Karahashi, Kazuhiro; Hamaguchi, Satoshi; Tatsumi, Tetsuya


    The etch rate of tin-doped indium oxide (or indium tin oxide, ITO) and the effects of a hydrogen-damaged layer caused by H2/Ar plasma were investigated using several surface analysis techniques. The ITO etch rate strongly depended on the H2/Ar flow rate ratio. The ITO was reduced by hydrogen injection and generated an In-rich (hydrogen-induced damage) layer on the surface. Because this In-rich layer had a higher sputtering yield, the hydrogen-damaged layer enhanced the ITO etch rate. Thus, the etching of ITO in H2/Ar plasma is determined by the balance between the formation of the In-rich damaged layer by H ion irradiation and the sputtering by Ar (relatively heavy inert gas) ions.

  20. A method for intercalibration of U-Th-Pb and 40Ar- 39Ar ages in the Phanerozoic (United States)

    Villeneuve, Mike; Sandeman, Hamish A.; Davis, William J.


    The increasing analytical precision of 40Ar- 39Ar geochronological data and its use in studies that combine U-Pb and 40Ar- 39Ar data has necessitated derivation of a means to intercalibrate ages between the two isotopic systems. The primary determinants inhibiting accurate cross calibration are uncertainty in decay constant values and uncertainty in 40Ar∗/ 40K (usually presented as apparent age) for 40Ar- 39Ar standards, notably those derived from the Fish Canyon Tuff. By utilizing a monazite- and biotite bearing Oligocene ash flow tuff (MAC-83) as the primary standard material, precise U-Th-Pb and 40Ar- 39Ar ages can be derived. Because both isotopic systems should reflect closure during the instantaneous eruption event, the 24.21 ± 0.10 Ma 207Pb/ 235U age should match the age resulting from 40Ar- 39Ar biotite analysis. This forced equivalence will partly offset the effects of decay constant uncertainty. Furthermore, by co-irradiating Fish Canyon Tuff sanidine with MAC-83 biotite, the apparent age for Fish Canyon Tuff sanidine is back-calculated to 27.98 ± 0.15 Ma, relative to the MAC-83 207Pb/ 235U age. Hence, intercalibration between the two isotopic systems in a relative sense can be accomplished, allowing for a direct and valid comparison of ages. It is also shown that forcing equivalence of the two isotopic systems minimizes the effect of decay constant uncertainty for samples of Phanerozoic age.

  1. Implementation of a Quality Improvement Process Aimed to Deliver Higher-Value Physical Therapy for Patients With Low Back Pain: Case Report. (United States)

    Karlen, Emily; McCathie, Becky


    The current state of health care demands higher-value care. Due to many barriers, clinicians routinely do not implement evidence-based care even though it is known to improve quality and reduce cost of care. The purpose of this case report is to describe a theory-based, multitactic implementation of a quality improvement process aimed to deliver higher-value physical therapy for patients with low back pain. Patients were treated from January 2010 through December 2014 in 1 of 32 outpatient physical therapy clinics within an academic health care system. Data were examined from 47,755 patients (mean age=50.3 years) entering outpatient physical therapy for management of nonspecific low back pain, with or without radicular pain. Development and implementation tactics were constructed from adult learning and change management theory to enhance adherence to best practice care among 130 physical therapists. A quality improvement team implemented 4 tactics: establish care delivery expectations, facilitate peer-led clinical and operational teams, foster a learning environment focused on meeting a population's needs, and continuously collect and analyze outcomes data. Physical therapy utilization and change in functional disability were measured to assess relative cost and quality of care. Secondarily, charge data assessed change in physical therapists' application of evidence-based care. Implementation of a quality improvement process was measured by year-over-year improved clinical outcomes, decreased utilization, and increased adherence to evidence-based physical therapy, which was associated with higher-value care. When adult learning and change management theory are combined in quality improvement efforts, common barriers to implementing evidence-based care can be overcome, creating an environment supportive of delivering higher-value physical therapy for patients with low back pain. © 2015 American Physical Therapy Association.

  2. Progress on using deuteron-deuteron fusion generated neutrons for 40Ar/39Ar sample irradiation (United States)

    Rutte, Daniel; Renne, Paul R.; Becker, Tim; Waltz, Cory; Ayllon Unzueta, Mauricio; Zimmerman, Susan; Hidy, Alan; Finkel, Robert; Bauer, Joseph D.; Bernstein, Lee; van Bibber, Karl


    We present progress on the development and proof of concept of a deuteron-deuteron fusion based neutron generator for 40Ar/39Ar sample irradiation. Irradiation with deuteron-deuteron fusion neutrons is anticipated to reduce Ar recoil and Ar production from interfering reactions. This will allow dating of smaller grains and increase accuracy and precision of the method. The instrument currently achieves neutron fluxes of ˜9×107 cm-2s-1 as determined by irradiation of indium foils and use of the activation reaction 115In(n,n')115mIn. Multiple foils and simulations were used to determine flux gradients in the sample chamber. A first experiment quantifying the loss of 39Ar is underway and will likely be available at the time of the presentation of this abstract. In ancillary experiments via irradiation of K salts and subsequent mass spectrometric analysis we determined the cross-sections of the 39K(n,p)39Ar reaction at ˜2.8 MeV to be 160 ± 35 mb (1σ). This result is in good agreement with bracketing cross-section data of ˜96 mb at ˜2.45 MeV and ˜270 mb at ˜4 MeV [Johnson et al., 1967; Dixon and Aitken, 1961 and Bass et al. 1964]. Our data disfavor a much lower value of ˜45 mb at 2.59 MeV [Lindström & Neuer, 1958]. In another ancillary experiment the cross section for 39K(n,α)36Cl at ˜2.8 MeV was determined as 11.7 ± 0.5 mb (1σ), which is significant for 40Ar/39Ar geochronology due to subsequent decay to 36Ar as well as for the determination of production rates of cosmogenic 36Cl. Additional experiments resolving the cross section functions on 39K between 1.5 and 3.6 MeV are on their way using the LICORNE neutron source of the IPN Orsay tandem accelerator. Results will likely be available at the time of the presentation of this abstract. While the neutron generator is designed for fluxes of ˜109 cm-2s-1, arcing in the sample chamber currently limits the power—straightforwardly correlated to the neutron flux—the generator can safely be run at. Further

  3. Enseñar a ser

    Directory of Open Access Journals (Sweden)

    García Barreno, Pedro


    Full Text Available El «Informe Delors», cuyo texto fue presentado hace ahora diez años, señala que cualquier proyecto educativo para el siglo XXI debe contemplar dos acciones. «Enseñar a conocer, a hacer, a vivir juntos, a ser», y garantizar el acceso de todos a ello. El siglo que concluyó apenas media docena de años, ha estado cargado de inmensas paradojas: entre grandes males, extraordinarios logros y no pocas esperanzas inalcanzadas. Marcado por dos guerras mundiales, por genocidios, por la acelerada degradación de la biosfera o por la miseria de una masa de marginados frente al creciente bienestar de los privilegiados.…

  4. Plasma AR and abiraterone-resistant prostate cancer. (United States)

    Romanel, Alessandro; Gasi Tandefelt, Delila; Conteduca, Vincenza; Jayaram, Anuradha; Casiraghi, Nicola; Wetterskog, Daniel; Salvi, Samanta; Amadori, Dino; Zafeiriou, Zafeiris; Rescigno, Pasquale; Bianchini, Diletta; Gurioli, Giorgia; Casadio, Valentina; Carreira, Suzanne; Goodall, Jane; Wingate, Anna; Ferraldeschi, Roberta; Tunariu, Nina; Flohr, Penny; De Giorgi, Ugo; de Bono, Johann S; Demichelis, Francesca; Attard, Gerhardt


    Androgen receptor (AR) gene aberrations are rare in prostate cancer before primary hormone treatment but emerge with castration resistance. To determine AR gene status using a minimally invasive assay that could have broad clinical utility, we developed a targeted next-generation sequencing approach amenable to plasma DNA, covering all AR coding bases and genomic regions that are highly informative in prostate cancer. We sequenced 274 plasma samples from 97 castration-resistant prostate cancer patients treated with abiraterone at two institutions. We controlled for normal DNA in patients' circulation and detected a sufficiently high tumor DNA fraction to quantify AR copy number state in 217 samples (80 patients). Detection of AR copy number gain and point mutations in plasma were inversely correlated, supported further by the enrichment of nonsynonymous versus synonymous mutations in AR copy number normal as opposed to AR gain samples. Whereas AR copy number was unchanged from before treatment to progression and no mutant AR alleles showed signal for acquired gain, we observed emergence of T878A or L702H AR amino acid changes in 13% of tumors at progression on abiraterone. Patients with AR gain or T878A or L702H before abiraterone (45%) were 4.9 and 7.8 times less likely to have a ≥50 or ≥90% decline in prostate-specific antigen (PSA), respectively, and had a significantly worse overall [hazard ratio (HR), 7.33; 95% confidence interval (CI), 3.51 to 15.34; P = 1.3 × 10(-9)) and progression-free (HR, 3.73; 95% CI, 2.17 to 6.41; P = 5.6 × 10(-7)) survival. Evaluation of plasma AR by next-generation sequencing could identify cancers with primary resistance to abiraterone.

  5. Erosion of FEP Teflon and PMMA by VUV radiation and hyperthermal O or Ar atoms. (United States)

    Zhang, Jianming; Lindholm, Ned F; Brunsvold, Amy L; Upadhyaya, Hari P; Minton, Timothy K; Tagawa, Masahito


    A combination of beam-surface-scattering, quartz-crystal-microbalance, and surface-recession experiments was conducted to study the effects of various combinations of O atoms [in the O((3)P) ground state], Ar atoms, and vacuum ultraviolet (VUV) light on fluorinated ethylene-propylene copolymer (FEP) Teflon and poly(methyl methacrylate) (PMMA). A laser-breakdown source was used to create hyperthermal beams containing O and O(2) or Ar. A D(2) lamp provided a source of VUV light. O atoms with 4 eV of translational energy or less did not react with a pristine FEP Teflon surface. Volatile O-containing reaction products were observed when the O-atom energy was higher than 4.5 eV, and the signal increased with the O-atom energy. Significant erosion of FEP Teflon ( approximately 20% of Kapton H) was observed when it was exposed to the hyperthermal O/O(2) beam with an average O-atom energy of 5.4 eV. FEP Teflon and PMMA that were exposed to VUV light alone exhibited much less mass loss. Collision-induced dissociation by hyperthermal Ar atoms also caused mass loss, similar in magnitude to that caused by VUV light. There were no observed synergistic effects when VUV light or Ar bombardment was combined with O/O(2) exposure. For both FEP Teflon and PMMA, the erosion yields caused by simultaneous exposure to O/O(2) and either VUV light or Ar atoms could be approximately predicted by adding the erosion yield caused by O/O(2), acting individually, to the erosion yield caused by the individual action of either VUV light or Ar atoms.

  6. Sm-Nd and Ar-Ar Studies of DHO 908 and 489: Implications for Lunar Crustal History (United States)

    Nyquist, L. E.; Shih, C. Y.; Reese, Y. D.; Park, J.; Bogard, D. D.; Garrison, D. H.; Yamaguchi, A.


    It is widely assumed that ferroan anorthosites (FANs) formed as flotation cumulates on a global lunar magma ocean (LMO). A corollary is that all FANs are approximately contemporaneous and formed with the same initial Nd-143/Nd-144 ratio. Indeed, a whole rock isochron for selected FANs (and An93 anorthosite) yields an isochron age of 4.42 +/- 0.13 Ga and initial Nd-143/Nd-144, expressed in epsilon-units, of epsilon(sub Nd,CHUR) = 0.3+/-0.3 relative to the CHondritic Uniform Reservoir , or epsilon(sub Nd,HEDPB)=-0.6+/-0.3 relative to the HED Parent Body. These values are in good agreement with the age (T) = 4.47+/-0.07 Ga, and epsilon(sub Nd,HEDPB) =-0.6 +/- 0.5 for FAN 67075. We also have studied anorthositic clasts in the Dhofar 908 and 489 lunar highland meteorites containing clasts of magnesian anorthosites (MAN) with Mg# approximately 75. Because of their relatively high Mg#, magnesian anorthosites should have preceded most FANs in crystallization from the LMO if both are LMO products. Thus, it is important to determine whether the Nd-isotopic data of MAN and FAN are consistent with a co-magmatic origin. We previously reported Sm-Nd data for white clast Dho 908 WC. Mafic minerals in this clast were too small to be physically separated for an isochron. However, we estimated initial Nd-143/Nd-144 for the clast by combining its bulk ("whole rock") Sm-Nd data with an Ar-39-Ar-40 age of 4.42+/-.04 Ga. Here we report additional Sm-Nd data for bulk samples of Dho 908 and its pair Dho 489.

  7. Practical reactor production of {sup 41}Ar from argon clathrate

    Energy Technology Data Exchange (ETDEWEB)

    Mercer, J.R. E-mail:; Duke, M.J.M.; McQuarrie, S.A


    The radionuclide {sup 41}Ar has many ideal properties as a gas flow tracer. However, the modest cross-section of {sup 40}Ar for thermal neutron activation makes preparation of suitable activities of {sup 41}Ar technically difficult particularly for low flux reactors. Argon can however be trapped in a molecular complex called a clathrate that can then be irradiated. We prepared argon clathrate and explored its irradiation and stability characteristics. Argon clathrate can be used to provide gigabecquerel quantities of {sup 41}Ar even with low power reactors.

  8. Expression of human AR cDNA driven by its own promoter results in mild promotion, but not suppression, of growth in human prostate cancer PC-3 cells%自身启动子驱动的人雄激素受体cDNA的表达能够适度促进而不是抑制人前列腺癌细胞PC-3的生长

    Institute of Scientific and Technical Information of China (English)

    Saleh Altuwaijri; Cheng-Chia Wu; Yuan-Jie Niu; Atsushi Mizokami; Hong-Chiang Chang; Chawnshang Chang


    Aim: To examine the physiological role of the androgen receptor (AR) in the PC-3 cell line by transfecting full-length functional AR cDNA driven by its natural human AR promoter. Methods: We generated an AR-expressing PC-3(AR)9 stable clone that expresses AR under the control of the natural human AR promoter and compared its proliferation to that of the PC-3(AR)2 (stable clone that expresses AR under the control of the cytomegalovirus (CMV) promoter,established by Heisler et al.) after androgen treatment. Results: We found that dihydrotestosterone (DHT) from 0.001 nmol/L to 10 nmol/L induces cell cycle arrest or inhibits proliferation of PC-3(AR)2 compared with its vector control, PC-3(pIRES). In contrast, PC-3(AR)9 cell growth slightly increased or did not change when treated with physiological concentrations of 1 nmol/L DHT. Conclusion: These data suggest that intracellular control of AR expression levels through the natural AR promoter might be needed for determining AR function in androgen-independent prostate cancer (AIPC) PC-3 cells. Unlike previous publications that showed DHT mediated suppression of PC-3 growth after transfection of viral promoter-driven AR overexpression, we report here that DHT-mediated PC-3 proliferation is slightly induced or does not change compared with its baseline after reintroducing AR expression driven by its own natural promoter, as shown in PC-3(AR)9 prostate cancer cells.

  9. 40Ar/39Ar dates from the West Siberian Basin: Siberian flood basalt province doubled. (United States)

    Reichow, Marc K; Saunders, Andrew D; White, Rosalind V; Pringle, Malcolm S; Al'Mukhamedov, Alexander I; Medvedev, Alexander I; Kirda, Nikolay P


    Widespread basaltic volcanism occurred in the region of the West Siberian Basin in central Russia during Permo-Triassic times. New 40Ar/39Ar age determinations on plagioclase grains from deep boreholes in the basin reveal that the basalts were erupted 249.4 +/- 0.5 million years ago. This is synchronous with the bulk of the Siberian Traps, erupted further east on the Siberian Platform. The age and geochemical data confirm that the West Siberian Basin basalts are part of the Siberian Traps and at least double the confirmed area of the volcanic province as a whole. The larger area of volcanism strengthens the link between the volcanism and the end-Permian mass extinction.

  10. 40Ar-39Ar age of carbonatite-alkaline magmatism in Sung Valley, Maghalaya, India

    Indian Academy of Sciences (India)

    Jyotiranjan S Ray; Kanchan Pande


    40Ar-39Ar analyses of one alkali pyroxenite whole rock and two phlogopite separates of calcite carbonatites from the Sung Valley carbonatite-alkaline complex, which is believed to be a part of the Rajmahal-Bengal-Sylhet (RBS) ood basalt province, yielded indistinguishable plateau ages of 108.8 ± 2.0 Ma, 106:4 ± 1.3 Ma and 107.5 ± 1.4 Ma, respectively. The weighted mean of these ages, 107.2 ± 0.8 Ma, is the time of emplacement of this complex. This implies that Sung Valley complex and probably other such complexes in the Assam-Meghalaya Plateau postdate the main ood basalt event (i.e., the eruption of tholeiites) in the RBS province by ∼10 Ma.

  11. Acoustic resonance spectroscopy (ARS): ARS300 operations manual, software version 2.01

    Energy Technology Data Exchange (ETDEWEB)



    Acoustic Resonance Spectroscopy (ARS) is a nondestructive evaluation technology developed at the Los Alamos National Laboratory. The ARS technique is a fast, safe, and nonintrusive technique that is particularly useful when a large number of objects need to be tested. Any physical object, whether solid, hollow, or fluid filled, has many modes of vibration. These modes of vibration, commonly referred to as the natural resonant modes or resonant frequencies, are determined by the object`s shape, size, and physical properties, such as elastic moduli, speed of sound, and density. If the object is mechanically excited at frequencies corresponding to its characteristic natural vibrational modes, a resonance effect can be observed when small excitation energies produce large amplitude vibrations in the object. At other excitation frequencies, i.e., vibrational response of the object is minimal.

  12. 40Ar/39Ar Age of the Lathrop Wells Volcanic Center, Yucca Mountain, Nevada. (United States)

    Turrin, B D; Champion, D; Fleck, R J


    Paleomagnetic and (40)Ar/(39)Ar analyses from the Lathrop Wells volcanic center, Nevada, indicate that two eruptive events have occurred there. The ages (136 +/- 8 and 141 +/- 9 thousand years ago) for these two events are analytically indistinguishable. The small angular difference (4.7 degrees ) between the paleomagnetic directions from these two events suggests they differ in age by only about 100 years. These ages are consistent with the chronology of the surficial geological units in the Yucca Mountain area. These results contradict earlier interpretations of the cinder-cone geomorphology and soil-profile data that suggest that at least five temporally discrete eruptive events occurred at Lathrop Wells approximately 20,000 years ago.

  13. Cooling age of Dabie orogen, China, determined by 40Ar-39Ar and fission track techniques

    Institute of Scientific and Technical Information of China (English)

    陈江峰; 谢智; 刘顺生; 李学明; K.A.Foland


    Based on 40Ar-39Ar results of hornblendes and biotites and fission track dating results of apatites separated from the same rock samples, cooling history of rocks from Dabie orogen is discussed. Rocks from both Southern Dabie Terrain (SDT) and Northern Dabie Terrain (NDT) have an early fast cooling followed by a more recent slow cooling. Rocks from SDT cooled to about 540℃ at about 190 Ma B.C., while rocks from NDT cooled to about 540℃ at 125 Ma B C. Until about 110-120 Ma B.C., rocks from both SDT and NDT cooled to about 100℃. This suggests that a relative movement among rocks from SDT, NDT and ul-Ira-high pressure metamorphic rocks exis-ts before 110-120 Ma B.C.

  14. Laser step-heating 40Ar/39Ar dating on young volcanic rocks

    Institute of Scientific and Technical Information of China (English)

    WANG Fei; HE Huaiyu; ZHU Rixiang; YANG Liekun; SANG Haiqing; WANG Yinglan


    An attempt was made to use CO2 laser step-heating method to date the late Pleistocene basaltic groundmass (DF-2) from Tengchong volcanic field. Among the fourteen heating steps, ten define a good inverse isochron (MSWD = 1.4) with an age of 32.2 ± 7.1 ka (2 σ).The inverse isochron also shows that the initial argon isotopic ratio is 297.1±2.0 (2σ)which is the same as the atmospheric argon at the 2σ error level. Study indicates that it is a useful means to date young volcanic groundmass with low K content by using CO2 laser step-heating 40Ar/39Ar method.

  15. 40Ar/39Ar dating of the Valsequillo volcanic deposits, Central Mexico: Resolution of an ongoing archaeological controversy and implications for the first human colonization of the 'New World' (United States)

    Mark, Darren


    It is currently accepted that the Clovis culture was the first to migrate into the New World at 13.1 ka [1]. However, archeological evidence in the form of stone tools, linguistics, craniometrics and genetics suggest that the first Americans were ethnically diverse and a few sites dated to 15-16 ka BP challenge the 'Clovis First' model. Perhaps the biggest challenge to the 'Clovis First' model was the reported presence of human footprints within a basaltic ash (Xalnene Ash) dated to 38.04 ± 8.57 ka using optically stimulated luminescence (OSL) [2]. However, Renne et al. [3] challenged the validity of the footprints by dating lapilli from the Xalnene ash using 40Ar/39Ar and reported an age of 1.30 ± 0.03 Ma (2σ). They also reported a reversed palaeomagnetic polarity for the ash, consistent with deposition during chron C1r.2r. Such antiquity casts considerable doubt on the interpretation of the impressions as human footprints. Gonzalez et al. [4] questioned the validity of the 40Ar/39Ar age and highlighted the heterogeneous nature of the lapilli as a potential problem for 40Ar/39Ar geochronology. The lapilli contain abundant phenocrysts and xenocrysts. Olivine phenocrysts can be contaminated with excess Ar (40ArE) [5] and hence the dating of 40ArE-bearing lapilli and xenocrystic material may potentially produce anomalously old 40Ar/39Ar ages. Gonzalez et al. [4] also dismissed the significance of the reversed palaeomagnetic polarity as the proposed age of the ash (38.04 ± 8.57 ka) overlapped with the Laschamp Geomagnetic Excursion at 40.4 ± 1.1 ka. Subsequently there has been support for both sides of the debate. The OSL age presented was questioned [6] and reconfirmed by [7]. The OU 40Ar/39Ar laboratory showed the presence of 40ArE in the samples although they were unable to date the ash [2]. Palaeomagnetic data has both supported emplacement of the Xalnene Ash during the LGE [8,9] and at 1.3 Ma [10]. The age of the 'alleged' footprint-bearing Xalnene ash and

  16. Implications of 40Ar/39Ar Geochronology for Fluid Transfer and Magma Generation Across Southeastern Guatemala (United States)

    Walker, J.; Bemis, K.; Cameron, B.; Noll, K.; Singer, B.; Zhang, X.; Ruscitto, D.; Roggensack, K.; Olney, J.


    Behind-the-front , or back-arc, monogenetic volcanism extends some 110 km across southeastern Guatemala providing an important window into fluid transfer and melting in the Central American subduction zone. New 40Ar/39Ar incremental heating measurements on basaltic lavas from cinder cones in southeastern Guatemala place important temporal constraints on this across-arc volcanism. Behind-the-front (BVF) volcanism has been notably long-lived: from 1070 ± 22 ka to 137 ± 25 ka. The morphologies of some undated cinder cones suggest that BVF volcanism has probably extended into the Holocene. Most morphological parameters for the dated cinder cones show no systematic changes with age, suggesting that cone degradation is rapid in the tropical climate of Guatemala, quickly approaching a morphological equilibrium stabilized by the thick vegetative cover. The volumes of cinder cones, however, have consistently increased towards the present. In additon, Ar/Ar ages become younger towards Pacaya volcano on the volcanic front, indicating a southwestward migration of eruptive activity with time. Some incompatible element concentrations and ratios, such as Ba, La, and La/Y, decrease with time suggesting increasing amounts of melting in the mantle wedge, consistent with the production of larger and larger cinder cones. Increasing melting, however, does not appear to be directly related to fluid transfer from the slab as the Ba/La, Ba/Th and U/Th ratios of basalts erupted from the dated cinder cones have also declined over time. Thus, the new age constraints suggest the increasing influence of decompression, versus flux, melting in the BVF region, an influence that has also spread into Pacaya volcano on the volcanic front (Cameron et al., 2002).

  17. Cerebral amyloid angiopathy-related inflammation presenting with steroid-responsive higher brain dysfunction: case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Maeda Yasushi


    Full Text Available Abstract A 56-year-old man noticed discomfort in his left lower limb, followed by convulsion and numbness in the same area. Magnetic resonance imaging (MRI showed white matter lesions in the right parietal lobe accompanied by leptomeningeal or leptomeningeal and cortical post-contrast enhancement along the parietal sulci. The patient also exhibited higher brain dysfunction corresponding with the lesions on MRI. Histological pathology disclosed β-amyloid in the blood vessels and perivascular inflammation, which highlights the diagnosis of cerebral amyloid angiopathy (CAA-related inflammation. Pulse steroid therapy was so effective that clinical and radiological findings immediately improved. CAA-related inflammation is a rare disease, defined by the deposition of amyloid proteins within the leptomeningeal and cortical arteries associated with vasculitis or perivasculitis. Here we report a patient with CAA-related inflammation who showed higher brain dysfunction that improved with steroid therapy. In cases with atypical radiological lesions like our case, cerebral biopsy with histological confirmation remains necessary for an accurate diagnosis.

  18. N 2-Ar-He compositions in fluid inclusions: Indicators of fluid source (United States)

    Norman, David I.; Musgrave, John A.


    A quadrupole mass spectrometer was used to measure bulk samples of conservative gas species N 2, Ar, and He in fluid inclusions from a variety of hydrothermal systems. Analyses of these tracer elements help determine (1) if gases extracted by bulk inclusion analyses can provide accurate measurement of N 2-Ar-He in active and fossil geothermal systems, (2) if hydrothermal fluids associated with paleogeothermal systems in a continental setting follow N 2ArHe systematics similar to th the western Pacific Rim active geothermal systems, specifically New Zealand, and (3) whether different deposit types systematically vary with regard to N 2ArHe. The N 2ArHe ratios of fluid inclusion volatiles released from recently deposited minerals from the Valles system are similar to those of present day Valles thermal waters. Those inclusion samples from deep within the Valles system, below a regional aquitard, increase in N 2. Compositions for inclusions from the Questa and Copper Flat-porphyry deposits are N 2-rich, similar to those of arc-related volcanic gases, whereas those from Taylor Creek Sn deposit appear to be mixtures of magmatic and crustal components. N 2-Ar-He ratios of the Precambrian Tribag deposit suggest a basalt source, but significant levels of self-generated He from U and Th in the inclusion fluids are also possible. Inclusions from two epithermal deposits with low-salinity inclusions have N 2-Ar-He ratios trending towards air-saturated meteoric waters (ASW), and those inclusions with higher salinities indicate minor to no ASW component. The N 2-Ar-He ratios in Fresnillo and Cochiti inclusions, which have magmatic helium isotopic ratios, indicate additions of magmatic gases to meteoric fluids. Inclusions from sediment-hosted deposits that contain hydrocarbon-bearing brines are He-rich, as are meteoric waters with a long residence time in the crust. At relevant pressure-temperature-composition conditions, Henry's Law constants of N 2, Ar, and He

  19. Spatial autocorrelation method using AR model; Kukan jiko sokanho eno AR model no tekiyo

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, H.; Obuchi, T.; Saito, T. [Iwate University, Iwate (Japan). Faculty of Engineering


    Examination was made about the applicability of the AR model to the spatial autocorrelation (SAC) method, which analyzes the surface wave phase velocity in a microtremor, for the estimation of the underground structure. In this examination, microtremor data recorded in Morioka City, Iwate Prefecture, was used. In the SAC method, a spatial autocorrelation function with the frequency as a variable is determined from microtremor data observed by circular arrays. Then, the Bessel function is adapted to the spatial autocorrelation coefficient with the distance between seismographs as a variable for the determination of the phase velocity. The result of the AR model application in this study and the results of the conventional BPF and FFT method were compared. It was then found that the phase velocities obtained by the BPF and FFT methods were more dispersed than the same obtained by the AR model. The dispersion in the BPF method is attributed to the bandwidth used in the band-pass filter and, in the FFT method, to the impact of the bandwidth on the smoothing of the cross spectrum. 2 refs., 7 figs.

  20. Construction and Identification of Recombinant Plasmids of Saccharomyces cerevisiae ARS304 and Its Flank Sequence%酿酒酵母ARS304及其侧翼序列重组质粒的构建与鉴定

    Institute of Scientific and Technical Information of China (English)

    李珺; 王馨; 张启声; 蔡禄


    ARS304 gene (S1) and its flank sequence (S2) of Saccharomyces cerevisiae were cloned by PCR, and then connected into the shuttle vector pRS405. Recombinant plasmids pRS1 and pRS2 were successfully constructed and used for electropo-ration of S. cerevisiae. Results showed that the electricity transformation rate of pRS2 was higher than that of pRS1, indicating that flank sequence could improve the autonomously replicating activity of ARS304 in S. cerevisiae.%采用PCR扩增酿酒酵母(Saccharomyces cerevisiae)Ⅲ号染色体ARS304序列(S1)及以ARS304为核心上下游延伸1 kb的侧翼序列(S2),并将目的片段分别构建到酵母整合载体pRS405中,获得重组质粒pRS1和pRS2.质粒电转化试验发现重组质粒pRS2的转化率大于pRS1,说明ARS304侧翼序列能显著提高ARS304在酿酒酵母中自主复制的能力.

  1. High Spatial Resolution 40Ar/39Ar Geochronology of Impact Melt Breccias from Apollo 17 Boulders at Stations 2, 6, and 7 (United States)

    Mercer, C. M.; Hodges, K. V.; Jolliff, B. L.; Van Soest, M. C.; Wartho, J. A.; Weirich, J. R.


    Several boulders located at the bases of the North and South Massifs were among the primary field targets of the Apollo 17 mission to the Taurus-Littrow Valley on the Moon [1]. Some boulders are polylithologic, including Boulder 1 at Station 2 and the boulders at Stations 6 and 7. These boulders were the subjects of consortium studies [2, 3] that included 40Ar/39Ar geochronology to determine the ages of distinct lithologies within each boulder [e.g., 4-6]. We report new 40Ar/39Ar data for the impact melt breccias 72255, 76315, 77075, and 77135 obtained using the UV laser ablation microprobe (UVLAMP) methods of [7]. For 72255, we obtained a preliminary isochron date ca. 3814 Ma from 22 melt analyses, which is younger than published plateau dates (e.g., 3951-3835 Ma [4, 8]). Fifteen melt analyses of 76315 yield a preliminary isochron date ca. 3850 Ma, younger than the 3900 ± 16 Ma date reported by [8]. Melt analyses of 77075 yield preliminary dates between ca. 3797-3584 Ma, possibly reflecting partial loss of 40Ar. In this case, the oldest date may provide a minimum age for the formation of melt in 77075. Finally, the UVLAMP dates for the 77135 melt range from 3810-3361 Ma and corresponding Ca/K ratios range from ca. 100-6. Electron microprobe analyses of small (ca. 10s of microns wide) pockets of K-rich materials show that both K-rich glass and K-feldspar are present. The UVLAMP dates for 77135 likely reflect spatially variable 40Ar loss, consistent with published step heating results [e.g., 6]. References: [1] Schmitt (1973) Science, 182, 681-690. [2] Ryder (1993). Catalog of Apollo 17 Rocks: Volume 1 - Stations 2 and 3 (South Massif). LPI. [3] Ryder (1993). Catalog of Apollo 17 Rocks: Volume 4 - North Massif. LPI. [4] Leich et al. (1975) The Moon, 14, 407-444. [5] Cadogan & Turner (1976). LPSC, 7, 2267-2285. [6] Stettler et al. (1978). LPSC, 9, 1113-1115. [7] Mercer et al. (2015) Sci. Adv., 1, e1400050. [8] Dalrymple & Ryder (1996). JGR, 101, 26069-26084.

  2. 75 FR 12163 - Class E Airspace; Mountain View, AR (United States)


    ... Federal Aviation Administration 14 CFR Part 71 Class E Airspace; Mountain View, AR AGENCY: Federal... proposes to amend Class E airspace at Mountain View, AR. Decommissioning of the Wilcox non-directional beacon (NDB) at Mountain View Wilcox Memorial Field Airport has made this action necessary for the...

  3. Aspects of What Makes or Breaks a Museum AR Experience

    DEFF Research Database (Denmark)

    Madsen, Claus B.; Madsen, Jacob Boesen; Morrison, Ann


    The paper critically evaluates central aspects of an iPad AR application developed for a museum context. The application is designed for children aged 8 to 12 and mixes AR and mini-game elements to convey dramatized historical events. The game has been deployed for roughly 3 months and the findin...

  4. Regulation of AR Degradation and Function by Ubiquitylation (United States)


    Identify ubiquitylation sites associated with degradation of the unliganded AR. We have used liquid chromatography followed by tandem mass spectrometry (LC...unmodified AR band in another gel slice). Protein in gel slices was then digested with trypsin (which leaves a gly-gly tag on ubiquitin-modified proteins

  5. Fenofibrate down-regulates the expressions of androgen receptor (AR) and AR target genes and induces oxidative stress in the prostate cancer cell line LNCaP

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Hu; Zhu, Chen; Qin, Chao [State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing (China); Tao, Tao [Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, Nanjing (China); Li, Jie; Cheng, Gong; Li, Pu; Cao, Qiang; Meng, Xiaoxin; Ju, Xiaobing; Shao, Pengfei; Hua, Lixin [State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing (China); Gu, Min, E-mail: [State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing (China); Yin, Changjun, E-mail: [State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing (China)


    Highlights: ► Fenofibrate induces cell cycle arrest in G1 phase and apoptosis in LNCaP cells. ► Fenofibrate reduces the expressions of androgen receptor in LNCaP cells. ► Fenofibrate induces oxidative stress in the prostate cancer cell line LNCaP. -- Abstract: Fenofibrate, a peroxisome proliferator-androgen receptor-alpha agonist, is widely used in treating different forms of hyperlipidemia and hypercholesterolemia. Recent reports have indicated that fenofibrate exerts anti-proliferative and pro-apoptotic properties. This study aims to investigate the effects of fenofibrate on the prostate cancer (PCa) cell line LNCaP. The effects of fenofibrate on LNCaP cells were evaluated by flow cytometry, reverse transcription-polymerase chain reaction, enzyme-linked immunosorbent assays, Western blot analysis, and dual-luciferase reporter assay. Fenofibrate induces cell cycle arrest in G1 phase and apoptosis in LNCaP cells, reduces the expressions of androgen receptor (AR) and AR target genes (prostate-specific antigen and TMPRSS2), and inhibits Akt phosphorylation. Fenofibrate can induce the accumulation of intracellular reactive oxygen species and malondialdehyde, and decrease the activities of total anti-oxidant and superoxide dismutase in LNCaP cells. Fenofibrate exerts an anti-proliferative property by inhibiting the expression of AR and induces apoptosis by causing oxidative stress. Therefore, our data suggest fenofibrate may have beneficial effects in fenofibrate users by preventing prostate cancer growth through inhibition of androgen activation and expression.

  6. Theoretical analysis of ion kinetic energies and DLC film deposition by CH4+Ar (He) dielectric barrier discharge plasmas

    Institute of Scientific and Technical Information of China (English)

    Liu Yan-Hong; Zhang Jia-Liang; Ma Teng-Cai; Li Jian; Liu Dong-Ping


    The kinetic energy of ions in dielectric barrier discharge plasmas are analysed theoretically using the model of binary collisions between ions and gas molecules. Langevin equation for ions in other gases, Blanc law for ions in mixed gases, and the two-temperature model for ions at higher reduced field are used to determine the ion mobility. The kinetic energies of ions in CH4 + Ar(He) dielectric barrier discharge plasma at a fixed total gas pressure and various Ar (He)concentrations are calculated. It is found that with increasing Ar (He) concentration in CH4 + Ar (He) from 20% to 83%,the CH4+ kinetic energy increases from 69.6 (43.9) to 92.1 (128.5)eV, while the Ar+ (He+) kinetic energy decreases from 97 (145.2) to 78.8 (75.5)eV. The increase of CH4+ kinetic energy is responsible for the increase of hardness of diamond-like carbon films deposited by CH4 + Ar (He) dielectric barrier discharge without bias voltage over substrates.

  7. Prediction of Chinese coal ash fusion temperatures in Ar and H{sub 2} atmospheres

    Energy Technology Data Exchange (ETDEWEB)

    Wen J. Song; Li H. Tang; Xue D. Zhu; Yong Q. Wu; Zi B. Zhu; Shuntarou Koyama [East China University of Science and Technology, Shanghai (China)


    The ash fusion temperatures (AFTs) of 21 typical Chinese coal ash samples and 60 synthetic ash samples were measured in Ar and H{sub 2} atmospheres. The computer software package FactSage was used to calculate the temperatures corresponding to different proportions of the liquid phase and predict the phase equilibria of synthetic ash samples. Empirical liquidus models were derived to correlate the AFTs under both Ar and H{sub 2} atmospheres of 60 synthetic ash samples, with their liquidus temperatures calculated by FactSage. These models were used to predict the AFTs of 21 Chinese coal ash samples in Ar and H{sub 2} atmospheres, and then the AFT differences between the atmospheres were analyzed. The results show that, for both atmospheres, there was an apparently linear correlation and good agreement between the AFTs of synthetic ash samples and the liquidus temperatures calculated by FactSage (R > 0.89, and {sigma} < 30{sup o}C). These models predict the AFTs of coal ash samples with a high level of accuracy (SE < 30{sup o}C). Because the iron oxides in coal ash samples fused under a H{sub 2} atmosphere are reduced to metallic iron and lead to changes of mineral species and micromorphology, the AFTs in a H{sub 2} atmosphere are always higher than those with an Ar atmosphere. 34 refs., 9 figs., 7 tabs.

  8. 40Ar/39Ar and (U-Th)/He model age signatures of elusive Mercurian and Venusian meteorites (United States)

    Jourdan, Fred; Eroglu, Ela


    No meteorites from Mercury and Venus have been conclusively identified so far. In this study, we develop an original approach based on extensive Monte Carlo simulations and diffusion models to explore the radiogenic argon (40Ar*) and helium (4He*) loss behavior and the range of 40Ar/39Ar and (U-Th)/He age signatures expected for a range of crystals if meteorites from these planets were ever to be found. We show that we can accurately date the crystallization age of a meteorite from both Mercury and Venus using the 40Ar/39Ar technique on clinopyroxene (± orthopyroxene) and that its 40Ar/39Ar age should match the Pb-Pb age. At the surface of Mercury, phases like albite and anorthite will exhibit a complete range of 40Ar* loss ranging from 0% to 100%, whereas merrillite and apatite will show 100% 4He* loss. By measuring the crystal size and diffusion parameters of a series of plagioclase crystals, one can inverse the 40Ar* loss value to estimate the maximum temperature experienced by a rock, and narrow down the possible pre-ejection location of the meteorite at the surface of Mercury. At the surface of Venus, plagioclase and phosphate phases will only record the age of ejection. The (U-Th)/He systematics of merrillite and apatite will be, respectively, moderately and strongly affected by 4He* loss during the transit of the meteorite from its host planet to Earth. Finally, meteorites from Mercury or Venus will each have their own 40Ar/39Ar and (U-Th)/He isotopic age and 38Arc cosmic ray exposure age signatures over a series of different crystal types, allowing to unambiguously recognize a meteorite for any of these two planets using radiogenic and cosmogenic noble gases.

  9. Comparison of Estimation Procedures for Multilevel AR(1 Models

    Directory of Open Access Journals (Sweden)

    Tanja eKrone


    Full Text Available To estimate a time series model for multiple individuals, a multilevel model may be used.In this paper we compare two estimation methods for the autocorrelation in Multilevel AR(1 models, namely Maximum Likelihood Estimation (MLE and Bayesian Markov Chain Monte Carlo.Furthermore, we examine the difference between modeling fixed and random individual parameters.To this end, we perform a simulation study with a fully crossed design, in which we vary the length of the time series (10 or 25, the number of individuals per sample (10 or 25, the mean of the autocorrelation (-0.6 to 0.6 inclusive, in steps of 0.3 and the standard deviation of the autocorrelation (0.25 or 0.40.We found that the random estimators of the population autocorrelation show less bias and higher power, compared to the fixed estimators. As expected, the random estimators profit strongly from a higher number of individuals, while this effect is small for the fixed estimators.The fixed estimators profit slightly more from a higher number of time points than the random estimators.When possible, random estimation is preferred to fixed estimation.The difference between MLE and Bayesian estimation is nearly negligible. The Bayesian estimation shows a smaller bias, but MLE shows a smaller variability (i.e., standard deviation of the parameter estimates.Finally, better results are found for a higher number of individuals and time points, and for a lower individual variability of the autocorrelation. The effect of the size of the autocorrelation differs between outcome measures.

  10. Laser fusion 40Ar/39Ar dating on young volcanic rocks.%(极)年轻火山岩激光熔蚀40Ar/39Ar定年

    Institute of Scientific and Technical Information of China (English)

    周晶; 季建清; Alan DEINO; 龚俊峰; 韩宝福; 涂继耀; 桑海清; 徐剑光


    It is extremely difficult to date young volcanic rocks.Accurate 40Ar/39Ar dating research and practice of young volcanic rocks in China put forward several notable and important points during the process of 40Ar/39 Ar dating for young volcanic rocks.Because of the low background level,small sample quantity,and high sensitivity of modem noble gas isotope mass spectrometry device,laser ablation 40Ar/39Ar dating technique has been used in depth application in volcanic rocks dating.With the laser in 40Ar/39Ar dating of young and modern volcanic rocks,the discrepancy of Nier value and initial argon isotope ratio in Quaternary samples may cause a remarkable deviation between K-Ar apparent age and 40 Ar/39 Ar apparent age.The deviation show exponential increase for samples younger than 0.2Ma,but it is not so notable for samples older than 2Ma.There out,the boundary of young and modern volcanic rocks,which is applied to 40 Ar/39 Ar system,is assigned at 0.2Ma:rocks aged 2 ~ 0.2Ma is defined as young volcanic rock,while rocks aged younger than 0.2Ma is defined as modem volcanic rock.The phenocrysts,which are from different argon isotope fractionation system,should be rejected from the sample during 40Ar/39 Ar dating.According to rock texture and grain size of mineral,the matrix should be picked with ideal grain size.In normal cases,about 0.2mm (or 60 ~ 80 mesh) is recommended; Cooling time after irradiation of fast neutron reactor should not be no more than three months,or else it may cause an error on 37 Ar measurement,and consequently on final results.As neutron-flux monitor,standards should be characteristic of high homogeneity during laser 40Ar/39Ar dating.In calibrating the international and domestic standards we have,we find that SB-778-Bi,Bern4M and BT-1 can be ideal standard samples with good homogeneity.We also find that the isochron age calculated from the laser 40Ar/39Ar data of the phenocryst and matrix,which were cooled and crystallized at the same time

  11. AR Sco: A White Dwarf Synchronar

    CERN Document Server

    Katz, J I


    The emission of the white dwarf-M dwarf binary AR Sco is driven by the rapid synchronization of its white dwarf, rather than by accretion. This requires a comparatively large magnetic field $\\sim 100$ gauss at the M dwarf and $\\sim 10^8$ gauss on the white dwarf, larger than the fields of most intermediate polars but within the range of fields of known magnetic white dwarfs. The spindown power is dissipated in the atmosphere of the M dwarf by magnetic reconnection, accelerating particles that produce the observed synchrotron radiation. The displacement of the optical maximum from conjunction may be explained either by dissipation in a bow wave as the white dwarf's magnetic field sweeps past the M dwarf or by a misaligned white dwarf's rotation axis and oblique magnetic moment. In the latter case the rotation axis precesses with a period of decades, predicting a drift in the orbital phase of maximum. Binaries whose emission is powered by synchronization may be termed synchronars, in analogy to magnetars.

  12. AR Sco: A Precessing White Dwarf Synchronar? (United States)

    Katz, J. I.


    The emission of the white dwarf–M dwarf binary AR Sco is driven by the rapid synchronization of its white dwarf, rather than by accretion. Synchronization requires a magnetic field ∼100 Gauss at the M dwarf and ∼ {10}8 Gauss at the white dwarf, larger than the fields of most intermediate polars but within the range of fields of known magnetic white dwarfs. The spindown power is dissipated in the atmosphere of the M dwarf, within the near zone of the rotating white dwarf’s field, by magnetic reconnection, accelerating particles that produce the observed synchrotron radiation. The displacement of the optical maximum from conjunction may be explained either by dissipation in a bow wave as the white dwarf’s magnetic field sweeps past the M dwarf or by a misaligned white dwarf rotation axis and oblique magnetic moment. In the latter case the rotation axis precesses with a period of decades, predicting a drift in the orbital phase of the optical maximum. Binaries whose emission is powered by synchronization may be termed synchronars, in analogy to magnetars.

  13. Ar plasma treated polytetrafluoroethylene films for a highly efficient triboelectric generator (United States)

    Kim, Dong Yeong; Kim, Hyun Soo; Jung, Jong Hoon


    We report an Ar plasma treated polytetrafluoroethylene (PTFE) film based triboelectric device for a highly enhanced electric power generation. The plasma treatment of the PTFE in flowing Ar gas results in a sharp increase in surface roughness ( 46 nm), as compared with the as-received film ( 25 nm). In addition, the F ion content decreases whereas the O ion increases with increasing plasma reaction time. Because of the increased number of polar O ions, the surface becomes hydrophilic, as confirmed by water contact angle measurements. After the Ar plasma treatment, the PTFE based triboelectric device, which is periodically contacted with and separated from the ITO electrode, generates a 715 V open-circuit voltage and a 16 μA closed-circuit current, which are almost 79 and 32 times larger than those for as-received PTFE based device. Using the Ar plasma treated PTFE based triboelectric generator, we can turn on the 120 light emitting diodes (LEDs) without any batteries.

  14. A collisional-radiative model for low-pressure weakly magnetized Ar plasmas (United States)

    Zhu, Xi-Ming; Tsankov, Tsanko; Czarnetzki, Uwe; Marchuk, Oleksandr


    Collisional-radiative (CR) models are widely investigated in plasma physics for describing the kinetics of reactive species and for optical emission spectroscopy. This work reports a new Ar CR model used in low-pressure (0.01-10 Pa) weakly magnetized (<0.1 Tesla) plasmas, including ECR, helicon, and NLD discharges. In this model 108 realistic levels are individually studied, i.e. 51 lowest levels of the Ar atom and 57 lowest levels of the Ar ion. We abandon the concept of an ``effective level'' usually adopted in previous models for glow discharges. Only in this way the model can correctly predict the non-equilibrium population distribution of close energy levels. In addition to studying atomic metastable and radiative levels, this model describes the kinetic processes of ionic metastable and radiative levels in detail for the first time. This is important for investigation of plasma-surface interaction and for optical diagnostics using atomic and ionic line-ratios. This model could also be used for studying Ar impurities in tokamaks and astrophysical plasmas.

  15. Absorption spectra of e-beam-excited Ne, Ar, and Kr, pure and in binary mixtures. (United States)

    Levchenko, A O; Ustinovskii, N N; Zvorykin, V D


    A technique using the broadband emission of a laser plume as probe radiation is applied to record UV-visible (190-510 nm) absorption spectra of Ne, Ar, and Kr, pure and in binary mixtures under moderate e-beam excitation up to 1 MW/cm(3). In all the rare gases and mixtures, the absorption spectra show continuum related to Rg(2) (+) homonuclear ions [peaking at λ∼285, 295, and 320 nm in Ne, Ar, and Kr(Ar/Kr), respectively] and a number of atomic lines related mainly to Rg(∗)(ms) levels, where m is the lowest principal quantum number of the valence electron. In argon, a continuum related to Ar(2) (∗) (λ∼325 nm) is also recorded. There are also trains of narrow bands corresponding to Rg(2) (∗)(npπ (3)Π(g))←Rg(2) (∗)(msσ (3)Σ(u) (+)) transitions. All the spectral features mentioned above were reported in literature but have never been observed simultaneously. Although charge transfer to a homonuclear ion of the heavier additive is commonly believed to dominate in binary rare-gas mixtures, it is found in this study that in Ne/Kr mixture, the charge is finally transferred from the buffer gas Ne(2) (+) ion not to Kr(2) (+) but to heteronuclear NeKr(+) ion.

  16. Combined optical emission and resonant absorption diagnostics of an Ar-O{sub 2}-Ce-reactive magnetron sputtering discharge

    Energy Technology Data Exchange (ETDEWEB)

    El Mel, A.A. [Chimie des Interactions Plasma-Surface (ChIPS), Research Institute for Materials Science and Engineering, Université de Mons, Place du Parc 23, Mons B-7000 (Belgium); Institut des Matériaux Jean Rouxel, Université de Nantes, CNRS, 2 rue de la Houssinière B.P. 32229, Nantes Cedex 3 44322 (France); Ershov, S. [Chimie des Interactions Plasma-Surface (ChIPS), Research Institute for Materials Science and Engineering, Université de Mons, Place du Parc 23, Mons B-7000 (Belgium); Britun, N., E-mail: [Chimie des Interactions Plasma-Surface (ChIPS), Research Institute for Materials Science and Engineering, Université de Mons, Place du Parc 23, Mons B-7000 (Belgium); Ricard, A. [Université de Toulouse, UPS, INPT, LAPLACE (Laboratoire Plasma et Conversion d' Energie), 118 route de Narbonne, Toulouse Cedex 9 F-31062 (France); Konstantinidis, S. [Chimie des Interactions Plasma-Surface (ChIPS), Research Institute for Materials Science and Engineering, Université de Mons, Place du Parc 23, Mons B-7000 (Belgium); Snyders, R. [Chimie des Interactions Plasma-Surface (ChIPS), Research Institute for Materials Science and Engineering, Université de Mons, Place du Parc 23, Mons B-7000 (Belgium); Materia Nova Research Center, Parc Initialis, Avenue Copernic 1, Mons B-7000 (Belgium)


    We report the results on combined optical characterization of Ar-O{sub 2}-Ce magnetron sputtering discharges by optical emission and resonant absorption spectroscopy. In this study, a DC magnetron sputtering system equipped with a movable planar magnetron source with a Ce target is used. The intensities of Ar, O, and Ce emission lines, as well as the absolute densities of Ar metastable and Ce ground state atoms are analyzed as a function of the distance from the magnetron target, applied DC power, O{sub 2} content, etc. The absolute number density of the Ar{sup m} is found to decrease exponentially as a function of the target-to-substrate distance. The rate of this decrease is dependent on the sputtering regime, which should be due to the different collisional quenching rates of Ar{sup m} by O{sub 2} molecules at different oxygen contents. Quantitatively, the absolute number density of Ar{sup m} is found to be equal to ≈ 3 × 10{sup 8} cm{sup −3} in the metallic, and ≈ 5 × 10{sup 7} cm{sup −3} in the oxidized regime of sputtering, whereas Ce ground state densities at the similar conditions are found to be few times lower. The absolute densities of species are consistent with the corresponding deposition rates, which decrease sharply during the transition from metallic to poisoned sputtering regime. - Highlights: • Optical emission and resonant absorption spectroscopy are employed to study Ar-O{sub 2}-Ce magnetron sputtering discharges. • The density of argon metastables is found to decrease exponentially when increasing the target-to-substrate distance. • The collision-quenching rates of Ar{sup m} by O{sub 2} molecules at different oxygen contents is demonstrated. • The deposition rates of cerium and cerium oxide thin films decrease sharply during the transition from the metallic to the poisoned sputtering regime.

  17. ``Smoking From The Same Pipe": Developement of an 40Ar/39Ar Datting Intercalibration PIpette System (Invited) (United States)

    Turrin, B. D.; Swisher, C. C.; Deino, A.; Hemming, S. R.; Hodges, K.; Renne, P. R.


    The precision and accuracy of Ar isotope ratio measurements is one of the main limiting factors in the uncertainties of an 40Ar/39Ar age. Currently, it is relatively common to measure Ar isotopic ratios to a precision of 1-2‰ or better on an intralaboratory basis. This level of analytical precision equates to a comparable level of precision (1-3‰) in the calculated age, depending on the extent of atmospheric Ar contamination, importance of nucleogenic interference corrections, and other factors. However, it has become clear that improving the precision of mass spectrometry is not the only bottleneck towards improving the accuracy and precision of 40Ar/39Ar dating in general. Rather, the most urgent issue is interlaboratory reproducibility. This became obvious in a recent EARTHTIME initiative undertaken to intercalibrate two commonly used 40Ar/39Ar standards [the Fish Canyon sanidine (FCs) and the Alder Creek sanidine (ACs)]. This effort revealed variations amongst laboratories (at the 1-2% level), an order of magnitude greater than the internal analytical precisions. To address these issues, we have proposed (to NSF) to construct two identical pipette systems loaded to identical starting pressures and with identical isotopic compositions. One pipette system will travel between participating 40Ar/39Ar labs and the second system will not travel and serve as the “Master” system to test for any fractionation or undocumented depletion of the traveling pipette system. In order to ensure delivery of uniform amounts of homogenous gas, the pipette system will be computer-controlled with preprogrammed routines and lockouts to prevent compromising the reservoirs. The pipette systems will deliver three gas samples with different isotopic ratios at two different pressures/concentrations. One pipette bulb will be of atmospheric isotopic composition, and the other two pipette bulbs will have 40Ar*/39ArK ratios corresponding to co-irradiated ACs and FCs fixed by their

  18. 40Ar/39Ar geochronology and exhumation of mylonitized metamorphic complex in Changle-Nanao ductile shear zone

    Institute of Scientific and Technical Information of China (English)

    王志洪; 卢华复


    New 40Ar/39Ar plateau ages from rocks of Changle-Nanao ductile shear zone are 107.9 Ma(Mus), 108.2 Ma(Bi), 107. 1 Ma(Bi), 109. 2 Ma(Hb) and 117. 9 Ma(Bi) respectively, which are concordant with their isochron ages and record the formation age of the ductile shear zone. The similarity and apparent overlap of the cooling ages with respective closure temperatures of 5 minerals document initial rapid uplift during 107-118 Ma following the collision between the Min-Tai microcontinent and the Min-Zhe Mesozoic volcanic arc. The 40Ar/39Ar plateau ages, K-Ar date of K-feldspar and other geochronologic information suggest that the exhumation rate of the ductile shear zone is about 0.18-1.12 mm/a in the range of 107-70 Ma, which is mainly influenced by tectonic extension.

  19. Ar Ar dating of authigenic K-feldspar: Quantitative modelling of radiogenic argon-loss through subgrain boundary networks (United States)

    Mark, D. F.; Kelley, S. P.; Lee, M. R.; Parnell, J.; Sherlock, S. C.; Brown, D. J.


    We have analysed two distinct generations of authigenic K-feldspar in Fucoid Bed sandstones from An-t-Sron and Skiag Bridge, NW Highlands, Scotland, which have experienced post-growth heating to levels in excess of the predicted Ar-closure temperature. Authigenic K-feldspars show microtextural similarities to patch perthites; that is subgrains separated by dislocation-rich boundary networks that potentially act as fast diffusion pathways for radiogenic argon. The two generations of authigenic K-feldspar in the Fucoid Bed sandstones can be distinguished by different microtextural zones, bulk mineral compositions, fluid-inclusion populations, and inferred temperatures and chemistries of parent fluids. Ar-Ar age data obtained using high-resolution ultraviolet laser ablation, show that the first cementing generation is Ordovician and the second cementing generation is Silurian. Modelling of Ar diffusion using subgrain size as the effective diffusion dimension and a simplified tectono-thermal thrust model assuming transient heating of the Fucoid Beds is inconsistent with observed data. Removal of heat from the thrust zone through rapid flushing of heated fluids rather than transient heating can be invoked to explain the observed Ar-Ar ages for both generations of cement. Alternatively, Ar-diffusion modelling using overgrowth thickness as the effective diffusion dimension instead of subgrain size also yields models that are consistent with both the Fucoid Bed palaeothermal maxima and determined Ar-Ar age ages for the two generations of K-feldspar cement. Based on this alternate explanation, we propose a theoretical microtextural model that highlights fundamental differences between the microtextures of deuterically formed patch perthites and authigenic K-feldspars, explaining the apparent robustness of authigenic K-feldspar with respect to Ar-retention.

  20. Ar-40/Ar-39 age determinations for the Rotoiti eruption, New Zealand (United States)

    Flude, S.; Storey, M.


    The contemporaneous Rotoiti and Earthquake Flat ignimbrites, erupted from the Taupo Volcanic zone, New Zealand, form a distinctive tephrostratigraphic horizon in the Southern Pacific. Radioisotopic dating results for these eruptions remain controversial, with published ages ranging from 35.1 × 2.8 ka [1] to 71 × 6 ka [2], with 61.0 × 1.5 ka [3] often being cited as the most widely accepted age. These eruptions are difficult to date as their age is near the limit for various radiometric dating techniques, which are complicated by a large proportion of inherited material (xenocrysts) and a lack of phases suitable for dating. Glass-bearing plutonic blocks erupted with the Rotoiti and Earthquake Flat ignimbrites have previously been interpreted as deriving from a slowly cooled and incompletely solidified magma body that was sampled by the eruptions. They contain large vugs lined with euhedral quartz, sanidine and biotite crystals, indicating that these crystals grew in a gas or aqueous fluid rich environment and are interpreted to have formed shortly before or during eruption. Here we will present Ar-40/Ar-39 ages for sanidines and biotites extracted from vugs in lithic blocks erupted as part of the Earthquake Flat ignimbrite. We show that, even for vug-lining material, inherited ages remain a problem and are the likely source of the wide variation in published radiometric ages. Nevertheless, many of the Ar-40/Ar-39 ages are much younger than the 61 ka age [3] and are more consistent with the recent stratigraphic, C-14 and U-238/Th-230+(U-Th)/He ages that have been suggested (e.g. [4,5]). 1. Whitehead, N. & Ditchburn, R. New Zealand Journal of Geology and Geophysics 37, 381-383 (1994). 2. Ota, Y., Omura, A. & Iwata, H. New Zealand Journal of Geology and Geophysics 32, 327-331 (1989). 3. Wilson, C. J. N. et al. Quaternary Science Reviews 26, 1861-1870 (2007). 4. Molloy, C., Shane, P. & Augustinus, P. Geological Society of America Bulletin 121, 1666-1677 (2009). 5

  1. High-precision 40Ar/39Ar age for the Jehol Biota (United States)

    Chang, S.; Zhang, H.; Renne, P. R.; Fang, Y.


    Abundant fossils of the terrestrial Jehol Biota, including plants, insects, dinosaurs, birds, mammals and freshwater invertebrates, were discovered from the Yixian Formation and the overlying Jiufotang Formation in Inner Mongolia, Hebei Province and Liaoning Province, northeastern China. Because of the exceptional preservation of fossils, the Jehol Biota is one of the most important Mesozoic fossil outcrops and referred to as a "Mesozoic Pompeii". The Jehol Biota has provided a rare opportunity to address questions about the origin of birds, the evolution of feathers and flight, the early diversification of angiosperms and the timing of the radiation of placental mammals. The Tuchengzi Formation, which lies unconformably just below the Yixian Formation and consists mainly of variegated sandstones, is less fossiliferous than the two overlying formations. However, dinosaur tracks, silicified wood and compressed plants are found in this formation. A systematic 40Ar/39Ar dating of the Yixian and the Jiufotang formations was undertaken to provide a framework for understanding the timing and duration of the Jehol Biota and evolutionary events represented within it. Furthermore, determining the absolute age of the Tuchengzi Formation provides information to interpret abundant dinosaur tracks within and provide better age constrains for the beginning of the Jehol Biota. Here we present robust high-precision 40Ar/39Ar data for six tuff samples and two basalt samples collected from the Tuchengzi, the Yixian and the Jiufotang formations near the classic outcrops in western Liaoning, NE China. We obtain an age of 139.5 ± 1.0 Ma for the uppermost Tuchengzi Formation, an age of 129.7 ± 0.5 Ma for a basaltic lava from the bottom of the Yixian Formation and an age of 122.1 ± 0.3 Ma for a tuff from the base of the overlying Jiufotang Formation. Our data indicate that the Yixian Formation was deposited during the Early Cretaceous, the Barremian to early Aptian, within a time span

  2. 40Ar/(39)Ar dating of the Kapthurin Formation, Baringo, Kenya. (United States)

    Deino, Alan L; McBrearty, Sally


    The(40)Ar/(39)Ar radiometric dating technique has been applied to tuffs and lavas of the Kapthurin Formation in the Tugen Hills, Kenya Rift Valley. Two variants of the(40)Ar/(39)Ar technique, single-crystal total fusion (SCTF) and laser incremental heating (LIH) have been employed to date five marker horizons within the formation: near the base, the Kasurein Basalt at 0.61+/-0.04 Ma; the Pumice Tuff at 0.543+/-0.004 Ma; the Upper Kasurein Basalt at 0.552+/-0.015 Ma; the Grey Tuff at 0.509+/-0.009 Ma; and within the upper part of the formation, the Bedded Tuff at 0.284+/-0.012 Ma. The new, precise radiometric age determination for the Pumice Tuff also provides an age for the widespread Lake Baringo Trachyte, since the Pumice Tuff is the early pyroclastic phase of this voluminous trachyte eruption. These results establish the age of fossil hominids KNM-BK 63-67 and KNM-BK 8518 at approximately 0.510-0.512 Ma, a significant finding given that few Middle Pleistocene hominids are radiometrically dated. The Kapthurin hominids are thus the near contemporaries of those from Bodo, Ethiopia and Tanzania. A flake and core industry from lacustrine sediments in the lower part of the formation is constrained by new dates of 0.55-0.52 Ma, a period during which the Acheulian industry, characterized by handaxes, is known throughout East Africa. Points, typical of the Middle Stone Age (MSA), are found in Kapthurin Formation sediments now shown to date to between 0.509+/-0.009 Ma and 0.284+/-0.012 Ma. This date exceeds previous estimates for the age of the MSA elsewhere in East Africa by 49 ka, and establishes the age of Acheulian to MSA transition for the region. Evidence of the use of the Levallois technique for the manufacture of both small flakes and biface preforms, the systematic production of blades, and the use and processing of red ochre also occurs in this interval. The presence of blades and red ochre at this depth is important as blades signify a high degree of technical

  3. Floristics of Higher Plants in China——Report from Catalogue of Life: Higher Plants in China Database%中国高等植物编目信息系统进展

    Institute of Scientific and Technical Information of China (English)

    Li-Song WANG; Yu-Cheng ZHANG; Na-Xin XUE; Hai-Ning QIN


    Biodiversity research increasingly relies on distribution networks for dealing with large-scale primary data.Up-to-date information on biodiversity is critical for the proper management and conservation of any area. The first step towards conservation should be to compile an authoritative species inventory or checklist. Catalogue of Life:Higher Plants in China (CNPC) is an ongoing biodiversity informatics project with the aim to integrate existing higher plants inventory data, and provide access via an internet based web service to public user and the scientific com-munity. The CNPC, for the first time, provides integrated and authoritative taxonomic information on higher plant species found in China, and this database will be permanent, free and continously updated. Presently, a total of 34377 species have been included in the database. Among of them, 16 620 species are only found in China. Taxa are classified into 432 families and 3 941 genera. The CNPC will be an important source for scientists working on Chinese flora, and will play an important role in helping to achieve the targets set under the Global Strategy for Plant Conservation in the future.

  4. 200 nm-1000 nm spectra of light emitted in the impact of 40Ar10+ upon Al and Si solid surfaces

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Xiaoan; (张小安); ZHAO; Yongtao; (赵永涛); LI; Fuli; (李福利); YANG; Zhihu(杨治虎); XIAO; Guoqing(肖国青); ZHAN; Wenlong(詹文龙)


    This paper reports the measured results of the 200 nm-1000 nm characteristic spectral lines of Al, Si and Ar atoms when highly charged ions 40Ar10+ are incident upon Al and P-type Si surfaces. The ion 40Ar10+ is provided by the ECR ion source of the National Laboratory of the Heavy Ion Accelerator in Lanzhou. The results show that when the low-speed ions in the highly charged state interact with the solid surfaces, the characteristic spectral lines of the target atoms and ions spurted from the surfaces can be effectively excited. Moreover, because of the competition of the non-radiation de-excitation of the hollow atom by emitting secondary electrons with the de-excitation process by radiating photons, the spectral intensity of the characteristic spectral lines of Ar atoms on the P-type Si surface is, as a whole, greater than that of Ar atoms on the Al surface.

  5. Women and Minority Faculty in the Academic Workplace: Recruitment, Retention, and Academic Culture. ASHE-ERIC Higher Education Report, Volume 27, Number 6. Jossey-Bass Higher and Adult Education Series. (United States)

    Aguirre, Adalberto, Jr.

    In an attempt to address the need for substantive comparisons in the minority university faculty population, this monograph examines the relative differences in minority groups in the faculty population when the data permit comparisons. The report also examines research on the status of women faculty members. The discussion assembles a large…

  6. The development of AR book for computer learning (United States)

    Phadung, Muneeroh; Wani, Najela; Tongmnee, Nur-aiynee


    Educators need to provide the alternative educational tools to foster learning outcomes of students. By using AR technology to create exciting edutainment experiences, this paper presents how augmented reality (AR) can be applied in the education. This study aims to develop the AR book for tenth grade students (age 15-16) and evaluate its quality. The AR book was developed based on ADDIE framework processes to provide computer learning on software computer knowledge. The content was accorded with the current Thai education curriculum. The AR book had 10 pages in three topics (the first was "Introduction," the second was "System Software" and the third was "Application Software"). Each page contained markers that placed virtual objects (2D animation and video clip). The obtained data were analyzed in terms of average and standard deviation. The validity of multimedia design of the AR book was assessed by three experts in multimedia design. A five-point Likert scale was used and the values were X¯ =4 .84 , S.D. = 1.27 which referred to very high. Moreover, three content experts, who specialize in computer teaching, evaluated the AR book's validity. The values determined by the experts were X¯ =4 .69 , S.D. = 0.29 which referred to very high. Implications for future study and education are discussed.

  7. Single-electron detachment cross sections in H{sup {minus}}+Ar

    Energy Technology Data Exchange (ETDEWEB)

    Kvale, T.J.; Sen, A.; Matulioniene, A.S.R.; Fang, X. [Univ. of Toledo, OH (United States)


    Measurements of absolute cross sections for the single electron detachment ({sigma}{sub -1,0}) in collisions between H{sup -} and Ar in the energy range 5-50 keV are reported. A well-collimated H{sup -} ion beam is directed toward an Ar gas target and all three of the exiting scattered beam components (i.e. H{sup 0}, H{sup +} and H{sup -}) are measured simultaneously. Using the closure relation among the collision beam components, (H{sup 0}, H{sup -} and H{sup +}) the neutral detection efficiencies are determined at each energy and thereby we are able to report absolute single detachment cross sections. The single detachment cross sections {sigma}{sub -1,0} exhibit a broad maximum with a value of 1.78 x 10{sup -15} cm{sup 2} at an impact energy of 25 keV.

  8. Nicotine induced CpG methylation of Pax6 binding motif in StAR promoter reduces the gene expression and cortisol production

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Tingting [Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071 (China); Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland (United States); Chen, Man; Liu, Lian [Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071 (China); Cheng, Huaiyan [Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland (United States); Yan, You-E [Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071 (China); Feng, Ying-Hong, E-mail: [Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland (United States); Wang, Hui, E-mail: [Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071 (China); Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071 (China)


    Steroidogenic acute regulatory protein (StAR) mediates the rate-limiting step in the synthesis of steroid hormones, essential to fetal development. We have reported that the StAR expression in fetal adrenal is inhibited in a rat model of nicotine-induced intrauterine growth retardation (IUGR). Here using primary human fetal adrenal cortex (pHFAC) cells and a human fetal adrenal cell line NCI-H295A, we show that nicotine inhibits StAR expression and cortisol production in a dose- and time-dependent manner, and prolongs the inhibitory effect on cells proliferating over 5 passages after termination of nicotine treatment. Methylation detection within the StAR promoter region uncovers a single site CpG methylation at nt -377 that is sensitive to nicotine treatment. Nicotine-induced alterations in frequency of this point methylation correlates well with the levels of StAR expression, suggesting an important role of the single site in regulating StAR expression. Further studies using bioinformatics analysis and siRNA approach reveal that the single CpG site is part of the Pax6 binding motif (CGCCTGA) in the StAR promoter. The luciferase activity assays validate that Pax6 increases StAR gene expression by binding to the glucagon G3-like motif (CGCCTGA) and methylation of this site blocks Pax6 binding and thus suppresses StAR expression. These data identify a nicotine-sensitive CpG site at the Pax6 binding motif in the StAR promoter that may play a central role in regulating StAR expression. The results suggest an epigenetic mechanism that may explain how nicotine contributes to onset of adult diseases or disorders such as metabolic syndrome via fetal programming. -- Highlights: Black-Right-Pointing-Pointer Nicotine-induced StAR inhibition in two human adrenal cell models. Black-Right-Pointing-Pointer Nicotine-induced single CpG site methylation in StAR promoter. Black-Right-Pointing-Pointer Persistent StAR inhibition and single CpG methylation after nicotine termination

  9. Raising aspirations: increasing the participation of students with Autistic Spectrum Disorders (Social Communication Difficulties) in Higher Education: report of the HEFCE strand two disability ASPIHE project


    Blamires, M.; Gee, S; HEFCE strand two disability


    The Higher Education Funding Council for England (HEFCE) funded a Social Communication and Understanding Project in Higher Education (ASPIHE) for a period of two years during 2000-2002. This was a strand two disability project, which aimed to promote and disseminate existing expertise and good practice across the higher education community. The focus was on support for students in higher education who have difficulties in social understanding and communication. This largely consists of studen...

  10. Symptoms of Allergic Rhinitis in Women during Early Pregnancy Are Associated with Higher Prevalence of Allergic Rhinitis in Their Offspring

    Directory of Open Access Journals (Sweden)

    Miwa Shinohara


    Results: Offspring whose mothers had any AR symptoms during early pregnancy showed a significantly higher adjusted odds ratio for the onset of AR in offspring than those whose mothers had no symptoms during pregnancy (adjusted Odds Ratio: 6.26, p=0.036. However, the symptoms of AR during late pregnancy showed no effects on the odds ratio. In contrast, the presence or absence of AR symptoms during early or late pregnancy showed no association with the prevalence of food allergy, atopic dermatitis or asthma in offspring. Conclusions: Our results suggest the presence of possible epigenetic mechanisms regulating the onset of AR in humans presumably through increased organ-specific hypersensitivity.

  11. Hyperon production in Ar+KCl collisions at 1.76A GeV



    We present transverse momentum spectra, rapidity distribution and multiplicity of Lambda-hyperons measured with the HADES spectrometer in the reaction Ar(1.76A GeV)+KCl. The yield of Xi- is calculated from our previously reported Xi-/(Lambda+Sigma0) ratio and compared to other strange particle multiplicities. Employing a strangeness balance equation the multiplicities of the yet unmeasured charged Sigma hyperons can be estimated. Finally a statistical hadronization model is used to fit the yi...

  12. Physical and optical limitations using ArF-excimer and Er:YAG lasers for PRK (United States)

    Semchishen, Vladimir A.; Mrochen, Michael; Seiler, Theo


    The Erbium:YAG laser emitting at a wavelength of 2,94 micrometer have been promised as an alternative laser for the ArF-excimer laser (193 nm) in photorefractive keratectomy (PRK). This report discusses the limitations of laser parameters such as wavelength, energy density and pulse duration for the ablation of the cornea. In addition, the melting process during ablation on the corneal surface roughness may play a role.

  13. Jurassic cooling ages in Paleozoic to early Mesozoic granitoids of northeastern Patagonia: 40Ar/39Ar, 40K-40Ar mica and U-Pb zircon evidence (United States)

    Martínez Dopico, Carmen I.; Tohver, Eric; López de Luchi, Mónica G.; Wemmer, Klaus; Rapalini, Augusto E.; Cawood, Peter A.


    U-Pb SHRIMP zircon crystallization ages and Ar-Ar and K-Ar mica cooling ages for basement rocks of the Yaminué and Nahuel Niyeu areas in northeastern Patagonia are presented. Granitoids that cover the time span from Ordovician to Early Triassic constitute the main outcrops of the western sector of the Yaminué block. The southern Yaminué Metaigneous Complex comprises highly deformed Ordovician and Permian granitoids crosscut by undeformed leucogranite dikes (U-Pb SHRIMP zircon age of 254 ± 2 Ma). Mica separates from highly deformed granitoids from the southern sector yielded an Ar-Ar muscovite age of 182 ± 3 Ma and a K-Ar biotite age of 186 ± 2 Ma. Moderately to highly deformed Permian to Early Triassic granitoids made up the northern Yaminué Complex. The Late Permian to Early Triassic (U-Pb SHRIMP zircon age of 252 ± 6 Ma) Cabeza de Vaca Granite of the Yaminué block yielded Jurassic mica K-Ar cooling ages (198 ± 2, 191 ± 1, and 190 ± 2 Ma). At the boundary between the Yaminué and Nahuel Niyeu blocks, K-Ar muscovite ages of 188 ± 3 and 193 ± 5 Ma were calculated for the Flores Granite, whereas the Early Permian Navarrete granodiorite, located in the Nahuel Niyeu block, yielded a K-Ar biotite age of 274 ± 4 Ma. The Jurassic thermal history is not regionally uniform. In the supracrustal exposures of the Nahuel Niyeu block, the Early Permian granitoids of its western sector as well as other Permian plutons and Ordovician leucogranites located further east show no evidence of cooling age reset since mica ages suggest cooling in the wake of crystallization of these intrusive rocks. In contrast, deeper crustal levels are inferred for Permian-Early Triassic granitoids in the Yaminué block since cooling ages for these rocks are of Jurassic age (198-182 Ma). Jurassic resetting is contemporaneous with the massive Lower Jurassic Flores Granite, and the Marifil and Chon Aike volcanic provinces. This intraplate deformational pulse that affected northeastern

  14. Infrared absorption spectroscopy of the COAr complex (United States)

    McKellar, A. R. W.; Zeng, Y. P.; Sharpe, S. W.; Wittig, C.; Beaudet, R. A.


    The rotation-vibration spectrum of the weakly bound complex COAr has been studied in the 2140 cm -1 region of the fundamental band of CO. Data were obtained from two different experiments: first, a pulsed slit-jet supersonic expansion and a tunable diode laser source; and second a long-path low-temperature static gas cell and a Fourier transform spectrometer. The low rotational temperature and narrow line width of the jet expansion data were complementary to the higher J-values and broad coverage of the static cell data. The observed spectrum was approximately that of a T-shaped near-prolate asymmetric rotor molecule. About 370 transitions were assigned to 6 perpendicular subbands with K = 3-2, 2-1, 1-0, 0-1, 1-2, and 2-3. No parallel (Δ K = 0) subbands were observed. The observed B rotational constant of the complex in its ground state, 0.0691 cm -1, corresponds to an effective intermolecular separation of about 3.850 Å. The observed A rotational constant of about 2.47 cm -1 is not too far from the overlineB value of the CO monomer, 1.92 cm -1, as expected for the approximately T-shaped effective geometry of the complex.

  15. A Survey on Web-based AR Applications

    CERN Document Server

    Parhizkar, Behrang; Lashkari, Arash Habibi; Bartaripou, Mohammad Mehdi; Babae, Hossein Reza


    Due to the increase of interest in Augmented Reality (AR), the potential uses of AR are increasing also. It can benefit the user in various fields such as education, business, medicine, and other. Augmented Reality supports the real environment with synthetic environment to give more details and meaning to the objects in the real word. AR refers to a situation in which the goal is to supplement a user's perception of the real-world through the addition of virtual objects. This paper is an attempt to make a survey of web-based Augmented Reality applications and make a comparison among them.

  16. A Survey on Web-based AR Applications

    Directory of Open Access Journals (Sweden)

    Behrang Parhizkar


    Full Text Available Due to the increase of interest in Augmented Reality (AR, the potential uses of AR are increasing also. It can benefit the user in various fields such as education, business, medicine, and other. Augmented Reality supports the real environment with synthetic environment to give more details and meaning to the objects in the real word. AR refers to a situation in which the goal is to supplement a user's perception of the real-world through the addition of virtual objects. This paper is an attempt to make a survey of web-based Augmented Reality applications and make a comparison among them.

  17. Dating slate belts using 40Ar/39Ar geochronology and zircon ages from crosscutting plutons: A case study from east-central Maine, USA (United States)

    Ghanem, Hind; Kunk, Michael J.; Ludman, Allan; Bish, David L.; Wintsch, Robert P.


    We report the ages of cleavage development in a normally intractable lower greenschist facies slate belt, the Central Maine-Aroostook-Matapedia belt in east-central Maine. We have attacked this problem by identifying the minimum ages of muscovite in a regional Acadian cleavage (S1) and in a local ductile fault zone cleavage (S2) using 40Ar/39Ar geochronology and the ages of crosscutting plutons. Our success stems from the regional low-grade metamorphism of the rocks in which each crystallization event preserves a40Ar/39Ar crystallization age and not a cooling age. Evidence for recrystallization via a pressure solution mechanism comes from truncations of detrital, authigenic, and in some rocks S1 muscovite and chlorite grains by new cleavage-forming muscovite and chlorite grains. Low-blank furnace age spectra from meta-arkosic and slaty rocks climb from moderate temperature Devonian age-steps dominated by cleavage-forming muscovite to Ordovician age-steps dominated by a detrital muscovite component. S1- and S2-cleaved rocks were hornfelsed by granitoids of ∼407 and 377 Ma, respectively. The combination of these minimum ages with the maximum metamorphic crystallization ages establishes narrow constraints on the timing of these two cleavage-forming events, ∼410 Ma (S1) and ∼380 Ma (S2). These two events coincide in time with a change in the plate convergence kinematics from the arrival of the Avalon terrane (Acadian orogeny), to a right-lateral transpression arrival of the Meguma terrane in the Neoacadian orogeny.

  18. Mass Spectrometric and Langmuir Probe Measurements in Inductively Coupled Plasmas in Ar, CHF3/Ar and CHF3/Ar/O2 Mixtures (United States)

    Kim, J. S.; Rao, M. V. V. S.; Cappelli, M. A.; Sharma, S. P.; Meyyappan, M.; Arnold, Jim (Technical Monitor)


    Absolute fluxes and energy distributions of ions in inductively coupled plasmas of Ar, CHF3/Ar, and CHF3/Ar/O2 have been measured. These plasmas were generated in a Gaseous Electronics Conference (GEC) cell modified for inductive coupling at pressures 10-50 mTorr and 100-300 W of 13.56 MHz radio frequency (RF) power in various feedgas mixtures. In pure Ar plasmas, the Ar(+) flux increases linearly with pressure as well as RF-power. Total ion flux in CHF3 mixtures decreases with increase in pressure and also CHF3 concentration. Relative ion fluxes observed in the present studies are analyzed with the help of available cross sections for electron impact ionization and charge-exchange ion-molecule reactions. Measurements of plasma potential, electron and ion number densities, electron energy distribution function, and mean electron energy have also been made in the center of the plasma with a RF compensated Langmuir probe. Plasma potential values are compared with the mean ion energies determined from the measured ion energy distributions and are consistent. Electron temperature, plasma potential, and mean ion energy vary inversely with pressure, but increase with CHF3 content in the mixture.

  19. (40)Ar/(39)Ar Age of Hornblende-Bearing R Chondrite LAP 04840 (United States)

    Righter, K.; Cosca, M.


    Chondrites have a complex chronology due to several variables affecting and operating on chondritic parent bodies such as radiogenic heating, pressure and temperature variation with depth, aqueous alteration, and shock or impact heating. Unbrecciated chondrites can record ages from 4.56 to 4.4 Ga that represent cooling in small parent bodies. Some brecciated chondrites exhibit younger ages (much less than 4 to 4.4 Ga) that may reflect the age of brecciation, disturbance, or shock and impact events (much less than 4 Ga). A unique R chondrite was recently found in the LaPaz Icefield of Antarctica - LAP 04840. This chondrite contains approximately 15% hornblende and trace amounts of biotite, making it the first of its kind. Studies have revealed an equigranular texture, mineral equilibria yielding equilibration near 650-700 C and 250-500 bars, hornblende that is dominantly OH-bearing (very little Cl or F), and high D/H ratios. To help gain a better understanding of the origin of this unique sample, we have measured the (40)Ar/(39)Ar age (LAP 04840 split 39).

  20. Characterization of novel StAR (steroidogenic acute regulatory protein mutations causing non-classic lipoid adrenal hyperplasia.

    Directory of Open Access Journals (Sweden)

    Christa E Flück

    Full Text Available CONTEXT: Steroidogenic acute regulatory protein (StAR is crucial for transport of cholesterol to mitochondria where biosynthesis of steroids is initiated. Loss of StAR function causes lipoid congenital adrenal hyperplasia (LCAH. OBJECTIVE: StAR gene mutations causing partial loss of function manifest atypical and may be mistaken as familial glucocorticoid deficiency. Only a few mutations have been reported. DESIGN: To report clinical, biochemical, genetic, protein structure and functional data on two novel StAR mutations, and to compare them with published literature. SETTING: Collaboration between the University Children's Hospital Bern, Switzerland, and the CIBERER, Hospital Vall d'Hebron, Autonomous University, Barcelona, Spain. PATIENTS: Two subjects of a non-consanguineous Caucasian family were studied. The 46,XX phenotypic normal female was diagnosed with adrenal insufficiency at the age of 10 months, had normal pubertal development and still has no signs of hypergonodatropic hypogonadism at 32 years of age. Her 46,XY brother was born with normal male external genitalia and was diagnosed with adrenal insufficiency at 14 months. Puberty was normal and no signs of hypergonadotropic hypogonadism are present at 29 years of age. RESULTS: StAR gene analysis revealed two novel compound heterozygote mutations T44HfsX3 and G221S. T44HfsX3 is a loss-of-function StAR mutation. G221S retains partial activity (∼30% and is therefore responsible for a milder, non-classic phenotype. G221S is located in the cholesterol binding pocket and seems to alter binding/release of cholesterol. CONCLUSIONS: StAR mutations located in the cholesterol binding pocket (V187M, R188C, R192C, G221D/S seem to cause non-classic lipoid CAH. Accuracy of genotype-phenotype prediction by in vitro testing may vary with the assays employed.

  1. La indagació en l’educació superior. Implicació i corresponsabilitat en l’acte d’ensenyar i aprendre a la universitat Investigation in higher education. Involvement and joint responsibility for university teaching and learning La indagación en la educación superior. Implicación y corresponsabilidad en el acto de enseñar y aprender en la universidad

    Directory of Open Access Journals (Sweden)

    Anna Forés Miravalles


    université dans la perspective d’impliquer les étudiants en expériences d’apprentissage que favorisent la compression et la signification suppose conditions pédagogiques clés, sans lesquelles la recherche est difficile. Créer un processus de recherche dans l’enseignement supérieur implique : d’envisager des conceptions éducatives qui favorisent des expériences d’apprentissage originales; et de développer des stratégies didactiques ainsi que des évaluations de recherche afin que les étudiant(es sentent qu’ils font partie du processus d’enseignement et d’apprentissage et qu’ils trouvent un espace pour développer leur propre travail et leur propre créativité, tout en s’attribuant et en attribuant aux autres l’autorité pour enseigner et apprendre.A key challenge will be faced by universities in the EHEA process is the need to consider more and more students as an actors, creators and responsibles for their own learning and less as a container and applicator information. This means involving the students in genuine research process to facilitate the development of their capacities and competences for searching, selecting, analysing, contrasting and critically interpreting information. The main actions involved in investigation are "to ask” and “to research” to gain knowledge. From this perspective, the role of university lecturers involves a series of essential educational approaches, without which it is difficult to investigate. The creation of an inquiry process in higher education entails the proposal of designs that foster genuine learning experiences, and the development of teaching strategies and investigative assessments. Thus, students can feel part of the teaching and learning process and find a space to develop their authorship and creativity. They can both claim and attribute to others the authority to teach and to learn.Un reto fundamental que tendrán que encarar las universidades en el proceso de construcción del EEES es la

  2. The Thermo Scientific HELIX-SFT noble gas mass spectrometer: (preliminary) performance for 40Ar/39Ar geochronology (United States)

    Barfod, D. N.; Mark, D. F.; Morgan, L. E.; Tomkinson, T.; Stuart, F.; Imlach, J.; Hamilton, D.


    The Thermo Scientific HELIX-platform Split Flight Tube (HELIX-SFT) noble gas mass spectrometer is specifically designed for simultaneous collection of helium isotopes. The high mass spur houses a switchable 1011 - 1012 Ω resistor Faraday cup and the low mass spur a digital pulse-counting secondary electron multiplier (SEM). We have acquired the HELIX-SFT with the specific intention to measure argon isotopes for 40Ar/39Ar geochronology. This contribution will discuss preliminary performance (resolution, reproducibility, precision etc.) with respect to measuring argon isotope ratios for 40Ar/39Ar dating of geological materials. We anticipate the greatest impact for 40Ar/39Ar dating will be increased accuracy and precision, especially as we approach the techniques younger limit. Working with Thermo Scientific we have subtly modified the source, alpha and collector slits of the HELIX-SFT mass spectrometer to improve its resolution for resolving isobaric interferences at masses 36 to 40. The enhanced performance will allow for accurate and precise measurement of argon isotopes. Preliminary investigations show that we can obtain a valley resolution of >700 and >1300 (compared to standard HELIX-SFT specifications of >400 and >700) for the high and low mass spurs, respectively. The improvement allows for full resolution of hydrocarbons (C3+) at masses 37 - 40 and almost full resolution at mass 36. The HELIX-SFT will collect data in dual collection mode with 40Ar+ ion beams measured using the switchable 1011 - 1012 Ω resistor Faraday cup and 39Ar through 36Ar measured using the SEM. The HELIX-SFT requires Faraday-SEM inter-calibration but negates the necessity to inter-calibrate multiple electron multipliers. We will further present preliminary data from the dating of mineral standards: Alder Creek sanidine, Fish Canyon sanidine and Mount Dromedary biotite (GA1550).

  3. Single-crystal 40Ar/39Ar incremental heating reveals bimodal sanidine ages in the Bishop Tuff (United States)

    Andersen, N. L.; Jicha, B. R.; Singer, B. S.


    The 650 km3 Bishop Tuff (BT) is among the most studied volcanic deposits because it is an extensive marker bed deposited just after the Matuyama-Brunhes boundary. Reconstructions of the vast BT magma reservoir from which high-silica rhyolite erupted have long influenced thinking about how large silicic magma systems are assembled, crystallized, and mixed. Yet, the longevity of the high silica rhyolitic melt and exact timing of the eruption remain controversial due to recent conflicting 40Ar/39Ar sanidine vs. SIMS and ID-TIMS U-Pb zircon dates. We have undertaken 21 40Ar/39Ar incremental heating ages on 2 mm BT sanidine crystals from pumice in 3 widely separated outcrops of early-erupted fall and flow units. Plateau ages yield a bimodal distribution: a younger group has a mean of 766 ka and an older group gives a range between 772 and 782 ka. The younger population is concordant with the youngest ID-TIMS and SIMS U-Pb zircon ages recently published, as well as the astronomical age of BT in marine sediment. Of 21 crystals, 17 yield older, non-plateau, steps likely affected by excess Ar that would bias traditional 40Ar/39Ar total crystal fusion ages. The small spread in older sanidine ages, together with 25+ kyr of pre-eruptive zircon growth, suggest that the older sanidines are not partially outgassed xenocrysts. A bimodal 40Ar/39Ar age distribution implies that some fraction of rhyolitic melt cooled below the Ar closure temperature at least 10 ky prior to eruption. We propose that rapid "thawing" of a crystalline mush layer released older crystals into rhyolitic melt from which sanidine also nucleated and grew immediately prior to the eruption. High precision 40Ar/39Ar dating can thus provide essential information on thermo-physical processes at the millenial time scale that are critical to interpreting U-Pb zircon age distributions that are complicated by large uncertainties associated with zircon-melt U-Th systematics.

  4. A Study of Compound Solar Eruption in NOAA AR11429 (United States)

    Zhang, Jie; Dhakal, Suman Kumar


    We analyze and report a compound eruption process associated with an M8.4 flare occurred on March 10, 2012 in NOAA AR 11429. In the main phase of the flare, there were two major peaks in GOES X-ray at ~17:20 UT and ~ 17:40 UT respectively. We found that the two flare peaks, separated by about 20 minutes, corresponded to two individual erupting magnetic flux bundles from the same active region and along the same magnetic polarity inversion line. The erupting features were seen as a hot channel-like structure of a temperature of ~ 10 MK in coronal images obtained from SDO AIA 131 A passband. We believe that each erupting feature is originated from an individual magnetic flux bundle. Prior to the onset of the eruption, the magnetic structure of the source region likely contains a double decker configuration, i.e., a coherent flux bundle lies above another coherent flux bundle. The upper bundle became unstable and started to erupt. Shortly after, the lower bundle started to accelerate and merged with the upper bundle, forming a single CME as seen in coronagraph images. This study demonstrates that complex magnetic configuration could form in the corona and result in a compound solar eruption that involves energy release in different magnetic structures. We will discuss the physical processes that inter-connect multiple magnetic structure in an active region.

  5. RadNet Air Data From Little Rock, AR (United States)

    This page presents radiation air monitoring and air filter analysis data for Little Rock, AR from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  6. H- Beam Stripping Loss at Background Partial Pressure of Ar

    Institute of Scientific and Technical Information of China (English)

    Hu Chundong; Wang Shaohu; Hu Liqun


    It has been observed that H- current could be improved by adding Ar to H2 plasma.But due to a slower pumping speed for Ar with the existing pumping scheme, the tank pressure will increase quickly during the length of a beam pulse. Since H- stripping loss depends on the tank pressure and gas species, part of the H- beam can be converted to H0 and then H0 can be converted into H+ with background H2 and Ar gas thickness. Therefore, the H- beam current,measured by a Faraday cup, situated at a distance L from GG (ground grid), will decrease because it will be converted into a H+ current. This gives a ratio of the Faraday cup net current to the H- beam current before stripping at background partial pressure of Ar.

  7. AR Ser: photometric observations of a Blazhko star (United States)

    Bonnardeau, Michel; Hambsch, Franz-Josef


    Photometric observations in 2010-2014 of the RR Lyrae star AR Serpentis are presented and analysed. Two Blazhko modulations of comparable amplitude are detected, with the periods 89 and 108 days, and with evidence for irregularities.

  8. Effect of Ar{sup +} irradiation on the behaviour of carbon nanotube transistor

    Energy Technology Data Exchange (ETDEWEB)

    Woo, Yun Sung; Roth, Siegmar [Max-Planck Institute for Solid State Research, Heisenbergstrasse 1, 70569 Stuttgart (Germany); Osvath, Z.; Vertesy, G.; Biro, L.P. [Research Institute for Technical Physics and Materials Science, 125 Budapest, P.O. Box 49 (Hungary)


    The characteristics of carbon nanotube field effect transistor are investigated after the whole device is irradiated with Ar{sup +} ions. The resistance become much higher due to the electron scattering at vacancies produced by Ar{sup +} irradiation. In addition, the subthreshold slop, S, (dV{sub G}/d(log I{sub D})) increases and the Schottky barrier height decreases after the irradiation, which imply the interface states generated within the band gap of the semiconducting single walled carbon nanotube. Therefore, we suggest a way that makes a transparent contact for electron transport by manipulating the vacancy formation at the interface between nanotube and metal leads. (copyright 2006 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  9. Nanoscale ripple formation in Co/Si(100) thin films with Ar{sup +} beam etching

    Energy Technology Data Exchange (ETDEWEB)

    Arranz, M A [Fac. Ciencias Quimicas, Universidad de Castilla-La Mancha, Camilo Jose Cela 10, 13071, Ciudad Real (Spain); Colino, Jose M, E-mail: HiguelAngel.Arranz@uclm.e [Instituto de Nanociencia, NanotecnologIa y Materiales Moleculares, UCLM, Campus de la Fabrica de Armas, 45071 Toledo (Spain)


    We have investigated the formation of nanoscale ripples on etched Co/Si(100) films with Ar{sup +} beam in grazing incidence. Topography and dimensions of those nanoscale patterns were characterized by means of atomic force microscopy. Polycrystalline cobalt thin films were deposited by d.c. magnetron sputtering onto Si(100) wafers and, later transferred in situ to a process chamber for the production of ripples. Their average width, W{sub d}, and separation between them, i.e. their periodicity {Lambda}, were found to monotonously increase first with the etching time and, finally, reach saturation values for long irradation times (around 30 min). The same Ar{sup +} beam etching applied on thicker Co films resulted in much wider and higher ripples, providing a more defined nanostructure for ulterior uniaxial magnetic anisotropy measurements. These changes in the ripple dimensions on increasing the Co film thickness are discussed in terms of the surface roughness in the as-deposited film.

  10. The emission spectra of Ar, Kr and Xe + TEA (United States)

    Suzuki, Masayo; Strock, Pierre; Sauli, Fabio; Charpak, Georges


    The emission spectra of Ar, Kr and Xe + 6% TEA gas mixtures are measured by using a single wire proportional counter as the emission source. Asymmetric emission bands are observed in the range of 270 to 350 nm, which can be attributed to the radiative deexcitation of excited TEA molecules. For the practical application of optical readout of avalanche chambers, the Ar + 2.0% TEA + 20% isobutane gas mixture is also examined, and nearly the same emission band is observed.

  11. Effect of Ar bubbling during plasma electrolytic oxidation of AZ31B magnesium alloy in silicate electrolyte (United States)

    Lee, Junghoon; Kim, Yonghwan; Chung, Wonsub


    Argon gas was bubbled during plasma electrolytic oxidation (PEO) treatment of magnesium alloy in a silicate solution. The appearance of arcs and plasma discharging was locally concentrated on the magnesium alloy surface and phase fraction of Mg2SiO4 in the oxide layer was increased due to Argon gas bubbling. The higher energy density of the Ar plasma atmosphere is believed to contribute to the effective formation of the high temperature phase (Mg2SiO4), particularly in the inner layer. Furthermore, the PEO treated Mg alloy with Ar bubbling showed improved corrosion resistance by a change of open pores structure.

  12. 40Ar-39Ar and U-Pb ages of metadiorite from the East Kunlun Orogenic Belt: Evidence for Early-Paleozoic magmatic zone and excess argon in amphibole minerals

    Institute of Scientific and Technical Information of China (English)


    Single-grain zircon U-Pb and amphibole 40Ar-39Ar dating have beenconducted on a deformed and metamorphosed diorite in the East Kunlun Orogenic Belt, which intruded into the middle Proterozoic Kuhai Group exposed in the south of Xiangride region, Dulan County, NW Qinghai Province. The zircon gives a concordant U-Pb age of (446.5±9.1) Ma. The amphibole yields Ar plateau age of (488.0±1.2) Ma and an isochronal age of (488.9±5.6) Ma. Age results of both stepwise released Ar and conventional K-Ar analysis are remarkably higher than that of zircon U-Pb, suggesting that the amphibole contains excess argon and the amphibole plateau age cannot be taken as the timing of metamorphism or deformation. The zircon age is interpreted to be crystallization age of the diorite pluton, which suggests that an Early-Paleozoic magmatic zone indeed existed in the East Kunlun Orogenic Belt stretching along the region south to the Golmud, Normuhong and Xiangride.

  13. Ars Moriendi: Coping with death in the Late Middle Ages. (United States)

    Espi Forcén, Fernando; Espi Forcén, Carlos


    The Ars moriendi was a book written in the early 15th century with the goal of assisting friars in their work of helping the dying. The aim of our study was to review the current literature on the Ars Moriendi concerning the field of medicine, to analyze the psychological mechanisms for coping with death anxiety within Ars Moriendi, and to explore parallels between the strategies used in the medieval book and in contemporary literature about death and dying. A review of literature using Pubmed, EMBASE, JSTOR, Project MUSE, and the New York Public Library was undertaken first. The primary source was then interpreted from a medical/psychological point of view. Seven articles were selected by literature review. These works comment on the importance of the Ars Moriendi in its historical context and explore the possibility of retrieving the principles of the text in contemporary society. The original text of Ars Moriendi, the primary source, presents death as a relief from the sufferings of earthly life and a gateway to eternal glory. According to the author, a good death implied the triumph over five demonic temptations in agonizing people: a lack of faith, despair, impatience, pride and greed. Analyzed from a modern psychiatric perspective, the Ars Moriendi offers descriptions of behavioral manifestations compatible with delirium, mood and anxiety disorders that characterize people with terminal illnesses. Moreover, we also explored parallels between the strategies used to cope with death anxiety in the Late Middle Ages and in contemporary society.

  14. A system for field gas-extraction of 85Kr, 39Ar and 81Kr using SuperPhobic membrane contactors (United States)

    Burk, L.; Suckow, A.; Cook, P.; Mathouchanh, E.


    Radioactive noble gas isotopes are established tools for assessing groundwater movement and transport processes on time scales of decades (85Kr), centuries (39Ar) and many millenia (81Kr). While the atomic trap trace analysis (ATTA) technology promises small sample sizes for these isotopes, field gas extraction will remain the method of choice for several years to come. Recently CSIRO obtained decommissioned radiocarbon gas proportional counters and targets to use them for 85Kr. We aim for a sample size of 50μL Kr corresponding to the gas extracted from 500-1000L water. Flinders University and CSIRO have developed a field-deployable extraction system for large volume gas-extraction in the field. It uses two membrane contactors (MEMBRANA SuperPhobic 4x13) allowing flow rates of up to 50L/min in serial mode. Switching to parallel flow through both contactors is possible, allowing even higher water flow rates. The system automatically logs water temperature, water pressure, water flow rate, gas pressure of the sample, vacuum pressure at the contactor and all valve states, using an Endress + Hauser RSG40 Memograph M. The use of SuperPhobic contactors results in ten times less water in the gas fraction than reported for earlier systems. With the two contactors in serial configuration, gas extraction efficiencies, determined for O2, N2 and Ar, are better than 95% at 5L/min water flow. They are still above 80% for flow rates up to 20L/min in parallel configuration for O2, N2 and Ar. No measurable isotopic fractionation of the target isotope ratios of argon and krypton is to be expected at these high extraction efficiencies.

  15. Chemical studies of L chondrites. III - Mobile trace elements and Ar-40/Ar-39 ages (United States)

    Huston, T. J.; Lipschutz, M. E.


    Radiochemical neutron activation analysis has been used to determine the content of the mobile trace elements Ag, Au, Bi, Cd, Co, Cs, Ga, In, Rb, Se, Te, Tl, and Zn, in L4-6 chondrites with undisturbed Ar-40 release patterns or patterns showing some 4.4-4.6 Gyr plateau disturbance that indicates some shock-induced loss. The mean concentrations are significantly lower in 16 chondrites with disturbed patterns than in 4 with undisturbed ones, consistent with shock-induced mobilization. Significantly lower mean concentrations of nearly all trace elements in 26 strongly shocked chondrites than in 14 mildly shocked ones indicate loss in shock-formed FeS-Fe eutectic and/or by means of vaporization during cooling of shock-heated collisional debris.

  16. The search for Ar in the lunar atmosphere using the Lunar Reconnaissance Orbiter's LAMP instrument. (United States)

    Cook, J. C.; Stern, S. A.; Feldman, P. D.; Gladstone, R.; Retherford, K. D.; Greathouse, T. K.; Grava, C.


    The Apollo 17 mass spectrometer, LACE, first measured mass 40 particles in the lunar atmosphere, and over a nine-month period, detected variations correlated with the lunar day (Hoffman et al., 1973, LPSC, 4, 2865). LACE detected a high particle density at dusk (0.6-1.0x104 cm-3), decreasing through the lunar night to a few hundred cm-3, then increasing rapidly before dawn to levels 2-4 times greater than at dusk. No daytime measurements were made due to instrument saturation. Given the LACE measurements' periodic nature, and the Ar abundance in lunar regolith samples (Kaiser, 1972, EPSL, 13, 387), it was concluded that mass 40 was likely due to Ar. Benna et al. (2014, LPSC, 45, 1535) recently reported that the Neutral Mass Spectrometer (NMS) aboard LADEE also detected Ar (mass 40) with similar diurnal profiles. We report on UV spectra of the lunar atmosphere as obtained by the Lunar Reconnaissance Orbiter (LRO). Aboard LRO is the UV-spectrograph, LAMP (Lyman Alpha Mapping Project), spanning the spectral range 575 to 1965 Å. LAMP is typically oriented toward the surface and has been mapping the Moon since September 2009. LAMP also observes the tenuous lunar atmosphere when the surface is in darkness, but the atmospheric column below LRO is illuminated. We have previously used nadir oriented twilight observations to examine the sparse lunar atmosphere (Feldman et al., 2012, Icarus, 221, 854; Cook et al., 2013, Icarus, 225, 681; Stern et al., 2013, Icarus, 226, 1210; Cook & Stern 2014, Icarus, 236, 48). In Cook et al., 2013, we reported an upper limit for Ar of 2.3x104 cm-3. Since then, we have collected additional data and refined our search method by focusing on the regions (near equator) and local times (dawn and dusk) where Ar has been reported previously. We have carefully considered effective area calibration and g-factor accuracies and find these to be unlikely explanations for the order of magnitude differences. We will report new results, which provide much

  17. 40Ar/39Ar geochronology of the Faku tectonites: Implications for the tectonothermal evolution of the Faku block, northern Liaoning

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Xiaohui; WANG; Hui; LI; Tiesheng


    For lack of reliable isotopic chronological data, the metamorphic rock series in the Faku region of northern Liaoning has long been regarded as the platform basement. Recent studies reveal that these deformed and metamorphosed rocks, with a variety of protoliths of plutonic intrusions and supracrustal volcanic and sedimentary rocks, were genetically related to later ductile shearing events, and they, together with the syntectonic intrusions, constituted the large-scale Faku tectonites. In this paper, we report new 40Ar/39Ar data on hornblende, biotite, and K-feldspar from typical granitic mylonites in this suite of tectonites. The plateau age 256 Ma of FK53 hornblende and the high-temperature plateau age 262 Ma of Fk51-1 biotite should represent the cooling ages when the granites, formed as a result of Paleozoic oceanic crustal subduction beneath the continental crust or collision of multiple micro-continental blocks, were exhumed into shallow crustal levels. The plateau age 231 Ma of FK51-1 boitite and the apparent age 227 Ma of Fk51-2 K-feldspar are interpreted to record the time of ductile deformation occurring under greenschist facies conditions, i.e. the formation age of the Faku tectonites, while the age gradient from 197 Ma to 220 Ma of Fk51-2 K-feldspar probably record the subsequent stable uplift-cooling process. The tectonic exhumation event indicated by the plateau age 180 Ma of Fk51-2 K-feldspar may be associated with the onset of paleo-Pacific subduction beneath the North China plate. In addition, the U-Pb dating of FK54 zircon from later-intruded granite yields the age of crystallization of this super-unit intrusion at 159 Ma, thus establishing an upper limit for the formation age of the Faku tectonites, while the plateau age 125 Ma of Fk54 K-feldspar most likely corresponds to the rapid cooling and tectonic denudation event associated with the final collision between the Siberian plate and the North China plate. These isotopic ages provide important

  18. Non-Adiabatic Dynamics of ICN-(Ar)n and BrCN-(Ar)n (United States)

    Opoku-Agyeman, Bernice; McCoy, Anne B.


    We investigate the dynamics of the photodissociation of ICN-(Ar)n and BrCN-(Ar)n following electronic excitation to states that dissociate into X- + CN and X* + CN- (X = I or Br) using classical dynamics approaches. Observations made from previous experiments and calculations of these anions demonstrated that non-adiabatic effects are important in the photodissociation process and are reflected in the branching ratios of the photoproducts. The addition of an argon atom is expected to shift the relative energies of these excited states, thereby altering the product branching. Interestingly, experimental studies show that electronically exciting ICN- solvated with even a single argon atom leads to a small fraction of the products recombine to form ICN-.a In this study, the dynamics are carried out using classical mechanics, treating the non-adiabatic effect with a surface hopping algorithm. We assess the accuracy of this approach by first calculating the branching ratios for the bare anions and comparing the results to those from quantum dynamics calculations.a,b Once the results from both the quantum and classical dynamics are shown to be consistent, the classical dynamics simulations are extended to the argon solvated anions. S. Case, E. M. Miller, J. P. Martin, Y. J. Lu, L. Sheps, A. B. McCoy, and W. C. Lineberger, Angew. Chem., Int. Ed. 51, 2651 (2012). B. Opoku-Agyeman, A. S. Case, J. H. Lehman, W. Carl Lineberger and A. B. McCoy, J. Chem Phys. 141, 084305 (2014). J. C. Tully, J. Chem Phys. 93, 1061 (1990).

  19. Combined U-Th/He and 40Ar/39Ar geochronology of post-shield lavas from the Mauna Kea and Kohala volcanoes, Hawaii

    Energy Technology Data Exchange (ETDEWEB)

    Aciego, S.M.; Jourdan, F.; DePaolo, D.J.; Kennedy, B.M.; Renne, P.R.; Sims, K.W.W.


    Late Quaternary, post-shield lavas from the Mauna Kea and Kohala volcanoes on the Big Island of Hawaii have been dated using the {sup 40}Ar/{sup 39}Ar and U-Th/He methods. The objective of the study is to compare the recently demonstrated U-Th/He age method, which uses basaltic olivine phenocrysts, with {sup 40}Ar/{sup 39}Ar ages measured on groundmass from the same samples. As a corollary, the age data also increase the precision of the chronology of volcanism on the Big Island. For the U-Th/He ages, U, Th and He concentrations and isotopes were measured to account for U-series disequilibrium and initial He. Single analyses U-Th/He ages for Hamakua lavas from Mauna Kea are 87 {+-} 40 ka to 119 {+-} 23 ka (2{sigma} uncertainties), which are in general equal to or younger than {sup 40}Ar/{sup 39}Ar ages. Basalt from the Polulu sequence on Kohala gives a U-Th/He age of 354 {+-} 54 ka and a {sup 40}Ar/{sup 39}Ar age of 450 {+-} 40 ka. All of the U-Th/He ages, and all but one spurious {sup 40}Ar/{sup 39}Ar ages conform to the previously proposed stratigraphy and published {sup 14}C and K-Ar ages. The ages also compare favorably to U-Th whole rock-olivine ages calculated from {sup 238}U - {sup 230}Th disequilibria. The U-Th/He and {sup 40}Ar/{sup 39}Ar results agree best where there is a relatively large amount of radiogenic {sup 40}Ar (>10%), and where the {sup 40}Ar/{sup 36}Ar intercept calculated from the Ar isochron diagram is close to the atmospheric value. In two cases, it is not clear why U-Th/He and {sup 40}Ar/{sup 39}Ar ages do not agree within uncertainty. U-Th/He and {sup 40}Ar/{sup 39}Ar results diverge the most on a low-K transitional tholeiitic basalt with abundant olivine. For the most alkalic basalts with negligible olivine phenocrysts, U-Th/He ages were unattainable while {sup 40}Ar/{sup 39}Ar results provide good precision even on ages as low as 19 {+-} 4 ka. Hence, the strengths and weaknesses of the U-Th/He and {sup 40}Ar/{sup 39}Ar methods are

  20. Combined U-Th/He and 40Ar/ 39Ar geochronology of post-shield lavas from the Mauna Kea and Kohala volcanoes, Hawaii (United States)

    Aciego, S. M.; Jourdan, F.; DePaolo, D. J.; Kennedy, B. M.; Renne, P. R.; Sims, K. W. W.


    Late Quaternary, post-shield lavas from the Mauna Kea and Kohala volcanoes on the Big Island of Hawaii have been dated using the 40Ar/ 39Ar and U-Th/He methods. The objective of the study is to compare the recently demonstrated U-Th/He age method, which uses basaltic olivine phenocrysts, with 40Ar/ 39Ar ages measured on groundmass from the same samples. As a corollary, the age data also increase the precision of the chronology of volcanism on the Big Island. For the U-Th/He ages, U, Th and He concentrations and isotopes were measured to account for U-series disequilibrium and initial He. Single analyses U-Th/He ages for Hamakua lavas from Mauna Kea are 87 ± 40 to 119 ± 23 ka (2 σ uncertainties), which are in general equal to or younger than 40Ar/ 39Ar ages. Basalt from the Polulu sequence on Kohala gives a U-Th/He age of 354 ± 54 ka and a 40Ar/ 39Ar age of 450 ± 40 ka. All of the U-Th/He ages, and all but one spurious 40Ar/ 39Ar ages conform to the previously proposed stratigraphy and published 14C and K-Ar ages. The ages also compare favorably to U-Th whole rock-olivine ages calculated from 238U- 230Th disequilibria. The U-Th/He and 40Ar/ 39Ar results agree best where there is a relatively large amount of radiogenic 40Ar (>10%), and where the 40Ar/ 36Ar intercept calculated from the Ar isochron diagram is close to the atmospheric value. In two cases, it is not clear why U-Th/He and 40Ar/ 39Ar ages do not agree within uncertainty. U-Th/He and 40Ar/ 39Ar results diverge the most on a low-K transitional tholeiitic basalt with abundant olivine. For the most alkalic basalts with negligible olivine phenocrysts, U-Th/He ages were unattainable while 40Ar/ 39Ar results provide good precision even on ages as low as 19 ± 4 ka. Hence, the strengths and weaknesses of the U-Th/He and 40Ar/ 39Ar methods are complimentary for basalts with ages of order 100-500 ka.

  1. Detecting harmonic signals in a noisy time-series: the z-domain Autoregressive (AR-z) spectrum (United States)

    Ding, Hao; Chao, Benjamin F.


    We develop a new method referred to as the AR-z spectrum for detecting harmonic signals with exponential decay/growth contained in a noisy time-series by extending the autoregressive (AR) method of Chao & Gilbert. The method consists of (i) `blindly' forcing one 2nd-order AR fit to the signal content in the frequency domain for any chosen frequency whether or not there is truly a signal; (ii) finding the corresponding AR (complex-conjugate pair of) poles in the complex z-domain; (iii) converting the pole locations into the corresponding complex frequencies of the harmonic signals via the Prony's relation and (iv) constructing the Lorentzian power spectrum in the z-domain, conceptually constituting the analytical continuation of the spectrum from the (real) frequency domain to the complex z-domain, where a true harmonic signal is manifested as a Lorentzian peak. The AR-z spectrum can be further enhanced by forming the product spectrum from multiple records as available. We apply the AR-z spectral method to detect and to estimate the complex frequencies of the Earth's normal-modes of free oscillation using superconducting gravimeter records after recent large earthquakes. Specifically we show examples of detection and precise estimation of the frequencies and Q values of the split singlets of the spheroidal modes 0S2, 2S1, 1S2 and 0S0, and report the mode couplings manifested by the gravimeter recording of the toroidal modes 0T2, 0T3 and 0T4. The AR-z spectrum proves to be highly sensitive for harmonic signal of decaying sinusoids in comparison to the conventional Fourier-based spectrum, particularly when the signal in question is weak and where high spectral resolution is desired.

  2. Effects of Ar/O{sub 2} gas ratio on ZnO films prepared by using ion beam deposition

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Myoung; Jeon, Juwon; Jeon, Daewoo; Sahoo, Trilochan; Lee, Mihee; Lee, Ruda; Jang, Leewoon; Ju, Jinwoo; Lee, Inhwan [Chonbuk National University, Jeonju (Korea, Republic of); Jo, Youngje; Kwak, Joonseop [Sunchon National University, Suncheon (Korea, Republic of)


    ZnO films were grown on (0001) sapphire substrates by using ion beam deposition. The effects of Ar/O{sub 2} gas ratio in the ion gun on the properties of the ZnO films were investigated. The films were deposited using various Ar/O{sub 2} gas ratios at room temperature (RT) and 400 .deg. C. All the ZnO films grown at RT showed a smooth and homogeneous surface with compressive strain. For an Ar/O{sub 2} gas ratio of 7/3, the ZnO film showed the lowest surface roughness and strain among the samples. At a higher substrate temperature of 400 .deg. C, the morphologies and the structural properties were more sensitive to the Ar/O{sub 2} gas ratios. Photoluminescence measurements showed that the samples deposited at RT exhibited strong deep level emissions in the visible range and near band edge emissions. On the other hand, the films prepared at 400 .deg. C displayed weaker defect related emissions. The present work suggests that the Ar/O{sub 2} gas ratio affects the stoichiometry and, thus, the structural and optical properties of the ZnO films.

  3. Exhumation history of the NW Indian Himalaya revealed by fission track and 40Ar/39Ar ages (United States)

    Schlup, M.; Steck, A.; Carter, A.; Cosca, M.; Epard, J.-L.; Hunziker, J.


    New fission track and Ar/Ar geochronological data provide time constraints on the exhumation history of the Himalayan nappes in the Mandi (Beas valley) - Tso Morari transect of the NW Indian Himalaya. Results from this and previous studies suggest that the SW-directed North Himalayan nappes were emplaced by detachment from the underthrusted upper Indian crust by 55. Ma and metamorphosed by ca. 48-40. Ma. The nappe stack was subsequently exhumed to shallow upper crustal depths (Elsevier Ltd.

  4. Exhumation history of the NW Indian Himalaya revealed by fission track and 40Ar/39Ar ages (United States)

    Schlup, Micha; Steck, Albrecht; Carter, Andrew; Cosca, Michael; Epard, Jean-Luc; Hunziker, Johannes


    New fission track and Ar/Ar geochronological data provide time constraints on the exhumation history of the Himalayan nappes in the Mandi (Beas valley) — Tso Morari transect of the NW Indian Himalaya. Results from this and previous studies suggest that the SW-directed North Himalayan nappes were emplaced by detachment from the underthrusted upper Indian crust by 55 Ma and metamorphosed by ca. 48–40 Ma. The nappe stack was subsequently exhumed to shallow upper crustal depths (

  5. Detection of a noble gas molecular ion, 36ArH+, in the Crab Nebula. (United States)

    Barlow, M J; Swinyard, B M; Owen, P J; Cernicharo, J; Gomez, H L; Ivison, R J; Krause, O; Lim, T L; Matsuura, M; Miller, S; Olofsson, G; Polehampton, E T


    Noble gas molecules have not hitherto been detected in space. From spectra obtained with the Herschel Space Observatory, we report the detection of emission in the 617.5- and 1234.6-gigahertz J = 1-0 and 2-1 rotational lines of (36)ArH(+) at several positions in the Crab Nebula, a supernova remnant known to contain both molecular hydrogen and regions of enhanced ionized argon emission. Argon-36 is believed to have originated from explosive nucleosynthesis in massive stars during core-collapse supernova events. Its detection in the Crab Nebula, the product of such a supernova event, confirms this expectation. The likely excitation mechanism for the observed (36)ArH(+) emission lines is electron collisions in partially ionized regions with electron densities of a few hundred per centimeter cubed.

  6. Students and teachers as developers of visual designs with AR for visual arts education

    DEFF Research Database (Denmark)

    Buhl, Mie


    Students and teachers as developers of visual learning designs with AR for visual arts education. This paper reports from a project where communication students collaborated with art teacher educators and art student teachers about developing visual digital designs for learning which involved...... mobile technology and Augmented Reality (AR). The project exemplified a strategy for visual learning design where diverse stakeholders’ competences were involved throughout the design process. Visual arts education in Denmark is challenged by the national curricula’s requirement of integrating digital...... technology in visual learning processes. Since 1984, information technology has been mandatory in the school subject as well as in teacher education (ref.). Still, many digital resources such as Photoshop and Paint, offer remediating more traditional means for pictorial production, which give rise...

  7. Engaging Our School Teachers: an Augmented Reality (AR Approach to Continuous Professional Development

    Directory of Open Access Journals (Sweden)

    Debbie Holley


    Full Text Available Currently, teachers in the UK learn about behaviour management strategies from theoretical perspectives when training, through discussions with mentors, and by trial and error at their schools. Existing literature mainly focuses on such issues from the ‘adult’ viewpoint, not the voice of the child. This paper reports on work-in-progress developing a range of Augmented Reality (AR resources for these issues, drawing upon co-design research workshops with children from a Year 6 class (aged 10 in a UK Primary School. Our research informs approaches to classroom management by encouraging reflection and analysis of ‘critical incidents’ identified by the pupils, and explored by teachers in workshops through the medium of AR, giving a reality previously uncaptured in more traditional approaches. Our final resources will be a set of Open Education Resources (OER, offered to the wider community for reuse/repurposing for educational settings through a Creative Commons (cc licence.

  8. Electronic structure modification of the KTaO3 single-crystal surface by Ar+ bombardment (United States)

    Wadehra, Neha; Tomar, Ruchi; Halder, Soumyadip; Sharma, Minaxi; Singh, Inderjit; Jena, Nityasagar; Prakash, Bhanu; De Sarkar, Abir; Bera, Chandan; Venkatesan, Ananth; Chakraverty, S.


    Oxygen vacancies play an important role in controlling the physical properties of a perovskite oxide. We report alterations in the electronic properties of a cubic perovskite oxide, namely, KTaO3, as a function of oxygen vacancies. The conducting surface of the KTaO3 single-crystal substrate has been realized via Ar+ irradiation. The band gap changes as a function of conductivity which is controlled by irradiation time, indicating the formation of defect states. Kelvin probe force microscopy suggests a sharp increase in the work function upon Ar+ irradiation for a short period of time followed by a monotonic decrease, as we increase the irradiation time. Our experimental findings along with theoretical simulations suggest a significant surface dipole contribution and an unusual change in the electronic band line-up of KTaO3 due to oxygen vacancies.

  9. The mass of sup 3 sup 2 Ar and sup 3 sup 3 Ar for fundamental tests

    CERN Document Server

    Blaum, K; Beck, D; Bollen, G; Herfurth, F; Kellerbauer, A G; Kluge, H J; Sauvan, E; Schwarz, S


    Masses of the short-lived radionuclides sup 3 sup 2 Ar (T sub 1 sub / sub 2 = 98 ms) sup 3 sup 3 Ar (T sub 1 sub / sub 2 = 173 ms) have been determined with the Penning trap mass spectrometer ISOLTRAP. Relative uncertainties of 6.0 x 10 sup - sup 8 (delta m = 1.8 keV) and 1.4 x 10 sup - sup 8 (delta m = 0.44 keV), respectively, have been achieved. At present, these new mass data serve as the most stringent test of the quadratic form of the isobaricmultiplet mass equation IMME. Furthermore, the improved accuracy for the mass of sup 3 sup 2 Ar yields a better constraint on scalar contributions to the weak interaction. New mass values have also been measured for sup 4 sup 4 Ar and sup 4 sup 5 Ar, and a 20 sigma deviation for sup 4 sup 4 Ar from the literature value was found and interpreted.

  10. HXeI and HXeH in Ar, Kr, and Xe matrices: experiment and simulation. (United States)

    Zhu, Cheng; Niimi, Keisuke; Taketsugu, Tetsuya; Tsuge, Masashi; Nakayama, Akira; Khriachtchev, Leonid


    Experimental and theoretical studies of HXeI and HXeH molecules in Ar, Kr, and Xe matrices are presented. HXeI exhibits the H-Xe stretching bands at 1238.0 and 1239.0 cm(-1) in Ar and Kr matrices, respectively, that are blue-shifted from the HXeI band observed in a Xe matrix (1193 cm(-1)) by 45 and 46 cm(-1). These shifts are larger than those observed previously for HXeCl (27 and 16 cm(-1)) and HXeBr (37 and 23 cm(-1)); thus, the matrix effect is stronger for less stable molecules. The results for HXeI are qualitatively different from all previous results on noble-gas hydrides with respect to the frequency order between Ar and Kr matrices. For previously studied HXeCl, HXeBr, and HXeCCH, the H-Xe stretching frequency is reliably (by >10 cm(-1)) higher in an Ar matrix than in a Kr matrix. In contrast, the H-Xe stretching frequency of HXeI in an Ar matrix is slightly lower than that in a Kr matrix. HXeH absorbs in Ar and Kr matrices at 1203.2 and 1192.1 cm(-1) (the stronger band for a Kr matrix), respectively. These bands are blue-shifted from the stronger band of HXeH in a Xe matrix (1166 cm(-1)) by 37 and 26 cm(-1), and this frequency order is the same as observed for HXeCl, HXeBr, and HXeCCH but different from HXeI. The present hybrid quantum-classical simulations successfully describe the main experimental findings. For HXeI in the 〈110〉 (double substitution) site, the order of the H-Xe stretching frequencies (ν(Xe) matrices from a Xe matrix are well predicted (30 and 34 cm(-1)). Both in the theory and experiment, the order of the H-Xe stretching frequencies differs from the case of HXeCl, which suggests the adequate theoretical description of the matrix effect. For HXeH in the 〈100〉 (single substitution) site, the order of the frequencies is ν(Xe) matrices with respect to a Xe matrix (36 and 23 cm(-1)) are in a good agreement with the experiments. The present calculations predict an increase of the H-Xe stretching frequencies in the noble-gas matrices

  11. Characterization of the optical properties of hydrophobic coatings and realization of high performance AR coatings with dust- and water-repellent properties (United States)

    Bruynooghe, S.; Spinzig, S.; Fliedner, M.; Hsu, G. J.


    Hydrophobic coatings enable the manufacture of easy-to-clean surfaces having dust- and water-repellent properties. In this work, a hydrophobic coating is deposited as a top layer on an antireflective (AR) multilayer system comprising a MgF2 upper layer to produce low reflectance optical surfaces at a normal incident angle in the visible spectrum with dust- and water-repellent properties for applications in precision optics. We report on the preparation and characterization of the optical properties of hydrophobic coatings deposited using a vacuum evaporation process and a commercially available water repellent substance. By means of a grazing incidence X-ray reflectometer it is shown that the hydrophobic coating can be considered, from an optical point of view, as two adjacent thin layers having specific thicknesses and densities. In fact, the hydrophobic layer is one monolayer comprising molecular chains with anchoring groups responsible for the chemical bond with the substrate material and functional groups responsible for the water- and oil-repellent properties. Optical constants are determined using a spectroscopic ellipsometer and are taken into account in the final multilayer system design. High performance AR coatings having an average reflectance of 0.14% at 7° incident angle in the 400-680nm spectral range together with a pleasing purple-red reflex color are produced. Coated lenses exhibit an excellent abrasion resistance, environmental stability, resistance to cleaning agents, homogeneity and water repellence with contact angles against water higher than 110°.

  12. Coexistence of Two- and Three-dimensional Shubnikov-de Haas Oscillations in Ar^+ -irradiated KTaO_3

    Energy Technology Data Exchange (ETDEWEB)

    Harashima, S.; Bell, C.; Kim, M.; Yajima, T.; Hikita, Y.; Hwang, H.Y.


    We report the electron doping in the surface vicinity of KTaO{sub 3} by inducing oxygen-vacancies via Ar{sup +}-irradiation. The doped electrons have high mobility (> 10{sup 4} cm{sup 2}/Vs) at low temperatures, and exhibit Shubnikov-de Haas oscillations with both two- and three-dimensional components. A disparity of the extracted in-plane effective mass, compared to the bulk values, suggests mixing of the orbital characters. Our observations demonstrate that Ar{sup +}-irradiation serves as a flexible tool to study low dimensional quantum transport in 5d semiconducting oxides.

  13. Optical Emission Spectroscopic Studies of ICP Ar Plasma

    Institute of Scientific and Technical Information of China (English)

    QI Xuelian; REN Chunsheng; ZHANG Jian; MA Tengcai


    The ion line of 434.8 nm and atom line of 419.8 nm of Ar plasma produced by an inductively coupled plasma (ICP) were measured by optical emission spectroscopy and the influences from the working gas pressure, radio-frequency (RF) power and different positions in the discharge chamber on the line intensities were investigated in this study. It was found that the intensity of Ar atom line increased firstly and then saturated with the increase of the pressure. The line intensity of Ar+, on the other hand, reached a maximum value and then decreased along with the pressure. The intensity of the line in an RF discharge also demonstrated a jumping mode and a hysteresis phenomenon with the RF power. When the RF power increased to 400 W, the discharge jumped from the E-mode to the H-mode where the line intensity of Ar atom demonstrated a sudden increase, while the intensity of Ar+ ion only changed slightly. If the RF power decreased from a high value, e.g., 1000 W, the discharge would jump from the H-mode back to the E-mode at a power of 300 W. At this time the intensities of Ar and Ar+ lines would also decrease sharply. It was also noticed in this paper that the intensity of the ion line depended on the detective location in the chamber, namely at the bottom of the chamber the line was more intense than that in the middle of the chamber, but less intense than at the top, which is considered to be related to the capacitance coupling ability of the ICP plasma in different discharge areas.

  14. Diboson Interference Resurrection arXiv

    CERN Document Server

    Panico, Giuliano; Wulzer, Andrea

    High-energy diboson processes at the LHC are potentially powerful indirect probes of heavy new physics, whose effects can be encapsulated in higher-dimensional operators or in modified Standard Model couplings. An obstruction however comes from the fact that leading new physics effects often emerge in diboson helicity amplitudes that are anomalously small in the Standard Model. As such, the formally leading Standard Model/New Physics interference contribution cancels in inclusive measurements. This paper describes a solution to this problem.

  15. Spectroscopic observation of (N2)2 dimers in free icosahedral N2 and Ar-N2 clusters

    CERN Document Server

    Doronin, Yu S; Samovarov, V N; Vakula, V L


    Supersonic-jet luminescence spectroscopy was applied to study vibronic transitions in icosahedral N2 and Ar-N2 clusters having from 100 to 400 particles per cluster. In the case of mixed Ar-N2 clusters, the w->X transitions were observed to occur in single N2 molecules in an Ar environment, that is very much in the same way as in Ar-N2 bulk samples. In N2 clusters, however, a band series was detected which was never observed earlier. In the spectra of Ar-N2 clusters, this new series coexisted with the 'bulk' w->X transitions. Our analysis demonstrated that the series should be assigned to emission of van der Waals (N2)2 dimers from inside clusters. Earlier, such dimers were only observed in molecular beams and gaseous nitrogen, this paper reports their observation in the solid phase of nitrogen suggesting that they may be the basic building blocks of small N2 clusters. Our results can be of interest from the viewpoint of producing polymeric nitrogen since (N2)2 dimers can be considered to be a starting specie...

  16. The effect of Gi-protein inactivation on basal, and β1- and β2AR-stimulated contraction of myocytes from transgenic mice overexpressing the β2-adrenoceptor


    Gong, Haibin; Adamson, Dawn L; Ranu, Hardeep K; Koch, Walter J.; Heubach, Jürgen F; Ravens, Ursula; Zolk, Oliver; Harding, Sian E


    The atria and ventricles of transgenic mice (TGβ2) with cardiac overexpression of the human β2-adrenoceptor (β2AR) were initially reported to show maximum contractility in the absence of β-AR stimulation. However, we have previously observed a different phenotype in these mice, with myocytes showing normal contractility but reduced βAR responses. We have investigated the roles of cyclic AMP and Gi in basal and βAR function in these myocytes.ICI 118,551 at inverse agonist concentrations decrea...

  17. Army Reserve (AR) Educational Assistance (EA) Study (United States)


    NAME(S) AND ADDRESS(ES) US Army TRADOC Analysis Center Ft. Lee, VA 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/ MONITORING AGENCY NAME(S...Programs REAP: Reserve Education Assistance Program; MGIB-SR: Montgomery GI Bill – Selected Reserve; SRK: Selected Reserve Kicker ; OFF: Officer; EM

  18. RBS-channeling study of radiation damage in Ar{sup +} implanted CuInSe{sub 2} crystals

    Energy Technology Data Exchange (ETDEWEB)

    Yakushev, Michael V., E-mail: [Department of Physics, SUPA, Strathclyde University, Glasgow G4 0NG (United Kingdom); Ural Federal University, Ekaterinburg 620002 (Russian Federation); Institute of Solid State Chemistry of the Urals Branch of RAS, Ekaterinburg 620990 (Russian Federation); Volkov, Vladimir A. [Ural Federal University, Ekaterinburg 620002 (Russian Federation); Mursakulov, Niyazi N.; Sabzaliyeva, Chimnaz E. [Institute of Physics, National Academy of Sciences of Azerbaijan, H.Cavid ave., 33, AZ-1143 Baku (Azerbaijan); Martin, Robert W. [Department of Physics, SUPA, Strathclyde University, Glasgow G4 0NG (United Kingdom)


    Chalcopyrite solar cells are reported to have a high tolerance to irradiation by high energy electrons or ions, but the origin of this is not well understood. This work studies the evolution of damage in Ar{sup +}-bombarded CuInSe{sub 2} single crystal using Rutherford backscattering/channeling analysis. Ar{sup +} ions of 30 keV were implanted with doses in the range from 10{sup 12} to 3 × 10{sup 16} cm{sup −2} at room temperature. Implantation was found to create two layers of damage: (1) on the surface, caused by preferential sputtering of Se and Cu atoms; (2) at the layer of implanted Ar, possibly consisting of stacking faults and dislocation loops. The damage in the second layer was estimated to be less than 2% of the theoretical prediction suggesting efficient healing of primary implantation defects.

  19. Smooth YBa2Cu3O7-x thin films prepared by pulsed laser deposition in O2/Ar atmosphere

    DEFF Research Database (Denmark)

    Kyhle, Anders; Skov, Johannes; Hjorth, Søren


    We report on pulsed laser deposition of YBa2Cu3O7-x in a diluted O2/Ar gas resulting in thin epitaxial films which are almost outgrowth-free. Films were deposited on SrTiO3 or MgO substrates around 800-degrees-C at a total chamber pressure of 1.0 mbar, varying the argon partial pressure from 0 to 0.......6 mbar. The density of boulders and outgrowths usual for laser deposited films varies strongly with Ar pressure: the outgrowth density is reduced from 1.4 x 10(7) to 4.5 x 10(5) cm-2 with increasing Ar partial pressure, maintaining a critical temperature T(c,zero) almost-equal-to 90 K and a transport...... critical current density J(c)(77 K) greater-than-or-equal-to 10(6) A/cm2 by extended oxygenation time during cool down....


    Institute of Scientific and Technical Information of China (English)



    Apart from the sample related factors, error control in both the measurement and afterward data processing is the key element in dating Quaternary geological samples by 40At/39Ar technique. Signals are usually linear or quadratic polynomial fitted. The adjusted value error will not be calculated via the error of coefficients in whatever the fitting equation, but will be obtained through a suitable procedure so as to be in harmony with the errors of the measured data. The error reduction in discrimination Correction coefficient D) , together with the error control in the measured Ar,will effectively cut down the Ar error caused by this correction. Errors in the 40Ar measurement,in the 36Ar measurement, in the calculated 36ArCa, in the calculated 36Arair, and finally in the calculated 39ArK, are all non-neglected sources of and will all be propagated into the calculated 40Arrad error. Samples with more atmospheric argon contamination and over-irradiation in younger rocks will cause more contribution of relative errors from 39ArK to 40Atrad. The fractional error in correction coefficient a is also an important source of errors when samples are irradiated in reactors with higher thermal neutron ratio and without Cd shielding. When using standard with ages older than lOOMa, the relative error of measured Rs keeps the same while that of decay constant and of standard age will be one to several times magnified ( compared to the error of Rs and the amplification factors respectively when standard age is less than 100Ma) will be one to several times magnified(compared to the amplification factor when standard age is less than 100Ma) and then be propagated into the relative error of J value and therefore increases the influence of these two sources to the error in J.%除了样品因素外,第四纪地质样品40Ar/39Ar测年的关键在于测试和年龄计算中的误差控制.信号强度(随测量时刻)的拟合值可以采用最小二乘法进行直线或二次多项

  1. High Resolution AR5 Simulations of Climate Change for Mesoamerica using WRF (United States)

    Rowe, C. M.; Oglesby, R. J.; Hays, C.


    Mesoamerica (the countries from Mexico to Colombia) has been identified by IPCC as a low-latitude, developing region at considerable risk to climate change. Furthermore, the complex topography of the region, and interactions with adjacent tropical oceans, makes understanding of potential climate change from global climate models alone very problematic. The real need, however, for making these extremely computationally-demanding model simulations is to better define local and regional climate change effects so as to better identify and quantify impacts and associated vulnerabilities. This is an essential precursor to developing robust adaptation strategies. Previously, we made simulations with the WRF regional climate model forced by the NCAR CCSM global climate model to make scenarios based on IPCC AR4. With the recent release of the CMIP global model runs for IPCC AR5, opportunity has been provided to update the previous simulations. From a technical perspective, two key advancements have taken place: 1) The global simulations for AR5 feature models that are significantly improved and are run at higher resolution, and 2) Enhancements to computational resources means that we can run WRF at very high resolution for much more of Mesoamerica. In particular, the mountainous area simulated at 4 km resolution has been expanded greatly; also Jamaica and Hispanola are also now included. The experiment strategy includes simulations for 2006-2010 ('control') and 2056-2060 ('climate change scenario'), under the IPCC A1B emission scenario. The runs are underway as of this writing (expected completion November 2011). First results will be presented at the meeting, with focus on both how they differ from the earlier AR4 simulations, and on key implications for the Mesoamerican region.

  2. Synergy between Prkdc and Trp53 regulates stem cell proliferation and GI-ARS after irradiation. (United States)

    Gurley, Kay E; Ashley, Amanda K; Moser, Russell D; Kemp, Christopher J


    Ionizing radiation (IR) is one of the most widely used treatments for cancer. However, acute damage to the gastrointestinal tract or gastrointestinal acute radiation syndrome (GI-ARS) is a major dose-limiting side effect, and the mechanisms that underlie this remain unclear. Here we use mouse models to explore the relative roles of DNA repair, apoptosis, and cell cycle arrest in radiation response. IR induces DNA double strand breaks and DNA-PK mutant Prkdc(scid/scid) mice are sensitive to GI-ARS due to an inability to repair these breaks. IR also activates the tumor suppressor p53 to trigger apoptotic cell death within intestinal crypt cells and p53 deficient mice are resistant to apoptosis. To determine if DNA-PK and p53 interact to govern radiosensitivity, we compared the response of single and compound mutant mice to 8 Gy IR. Compound mutant Prkdc(scid/scid)/Trp53(-/-)mice died earliest due to severe GI-ARS. While both Prkdc(scid/scid) and Prkdc(scid/scid)/Trp53(-/-)mutant mice had higher levels of IR-induced DNA damage, particularly within the stem cell compartment of the intestinal crypt, in Prkdc(scid/scid)/Trp53(-/-)mice these damaged cells abnormally progressed through the cell cycle resulting in mitotic cell death. This led to a loss of Paneth cells and a failure to regenerate the differentiated epithelial cells required for intestinal function. IR-induced apoptosis did not correlate with radiosensitivity. Overall, these data reveal that DNA repair, mediated by DNA-PK, and cell cycle arrest, mediated by p53, cooperate to protect the stem cell niche after DNA damage, suggesting combination approaches to modulate both pathways may be beneficial to reduce GI-ARS. As many cancers harbor p53 mutations, this also suggests targeting DNA-PK may be effective to enhance sensitivity of p53 mutant tumors to radiation.

  3. 40Ar/39Ar dating of the Honghuaqiao Formation in SE China (United States)

    Chang, S.; Zhang, H.; Hemming, S. R.; Mesko, G. T.; Fang, Y.


    The Jehol Biota, defined as the characteristic Eosestheria-Ephemeropsis-Lycoptera assemblage (Grabau, 1923, Bulletin of the Geological Survey of China), is widely distributed in eastern and central Asia (Li et al., 1982, Acta Geologica Sinica; Chen, 1988, Acta Palaeontologica Sinica). Abundant and varied fossils of the terrestrial Jehol Biota, including plants, insects, dinosaurs, birds, mammals, and freshwater invertebrates, have been discovered from the Dabeigou, the Yixian and the Jiufotang Formations (or their correlative strata) in northeast China from the Liaoning and Hebei Provinces and Inner Mongolia (Chen and Jin, 1999, Acta Palaeontologica Sinica). In addition, strata that may be correlative with the classic Jehol fossil-bearing formations have been identified extensively in central and eastern China, the Korean Peninsula, Mongolia, and Siberia. In the past three decades mollusk, conchostracan, ostracod, insect, fish, and plant fossils from localities in southeastern China, interpreted as related to the Jehol biota of the northeast, have been found (Mateer and Chen, 1986, Cretaceous Research; Li, 2003, Chinese Science Bulletin; Chen, Li and Batten, 2007, Geological Journal). However, a detailed correlation between the classic Jehol outcrops and the more recently found localities to the South and West has yet to emerge. Volcanic rocks from the Honghuaqiao fossil-bearing Formation in Tuzhou City of eastern Anhui Province, southeastern China provide an excellent opportunity to rectify this situation. Preliminary results of a pilot study suggest that the Honghuaqiao Formation is equivalent to the Longwanshan Formation of Anhui Province, southeastern China and the Yixian Formation, northeastern China (Chang et al., 2009, AGU abstract). Initial 40Ar/39Ar results indicate that conchostracans from the upper Honghuaqiao Formation are approximately 130 Ma. Our ongoing work aims to establish a high-resolution chronostratigraphy for Tuzhou City in Anhui Province

  4. Measurement of the attenuation length of argon scintillation light in the ArDM LAr TPC

    CERN Document Server

    Calvo, J; Crivelli, P; Daniel, M; DiLuise, S; Gendotti, A; Horikawa, S; Molina-Bueno, L; Montes, B; Mu, W; Murphy, S; Natterer, G; Ngyuen, K; Periale, L; Quan, Y; Radics, B; Regenfus, C; Romero, L; Rubbia, A; Santorelli, R; Sergiampietri, F; Viant, T; Wu, S


    We report on a measurement of the attenuation length for the scintillation light in the tonne size liquid argon target of the ArDM dark matter experiment. The data was recorded in the first underground operation of the experiment in single-phase operational mode. The results were achieved by comparing the light yield spectra from 39-Ar and 83m-Kr to a description of the ArDM setup with a model of full light ray tracing. A relatively low value close to 0.5 m was found for the attenuation length of the liquid argon bulk to its own scintillation light. We interpret this result as a presence of optically active impurities in the liquid argon which are not filtered by the installed purification systems. We also present analyses of the argon gas employed for the filling and discuss cross sections in the vacuum ultraviolet of various molecules in respect to purity requirements in the context of large liquid argon installations.

  5. Kinetic Energy and Angular Distributions of He and Ar Atoms Evaporating from Liquid Dodecane. (United States)

    Patel, Enamul-Hasan; Williams, Mark A; Koehler, Sven P K


    We report both kinetic energy and angular distributions for He and Ar atoms evaporating from C12H26. All results were obtained by performing molecular dynamics simulations of liquid C12H26 with around 10-20 noble gas atoms dissolved in the liquid and by subsequently following the trajectories of the noble gas atoms after evaporation from the liquid. Whereas He evaporates with a kinetic energy distribution of (1.05 ± 0.03) × 2RT (corrected for the geometry used in experiments: (1.08 ± 0.03) × 2RT, experimentally obtained value: (1.14 ± 0.01) × 2RT), Ar displays a kinetic energy distribution that better matches a Maxwell-Boltzmann distribution at the temperature of the liquid ((0.99 ± 0.04) × 2RT). This behavior is also reflected in the angular distributions, which are close to a cosine distribution for Ar but slightly narrower, especially for faster atoms, in the case of He. This behavior of He is most likely due to the weak interaction potential between He and the liquid hydrocarbon.

  6. {sup 40}Ar-{sup 39}Ar dating of terrestrial and exterrestrial materials. Basalts from the Japan Sea floor, Deccan Plateau and meteorites from Antarctica

    Energy Technology Data Exchange (ETDEWEB)

    Kaneoka, Ichiro [Tokyo Univ. (Japan). Earthquake Research Inst.; Takigami, Yutaka


    Through a series of {sup 40}Ar-{sup 39}Ar dating for terrestrial and exterrestrial samples, the results for basalts from the Japan Sea floor, Deccan Plateau and for meteorites from Antarctica give significant information concerning their formation histories. {sup 40}Ar-{sup 39}Ar ages of basalts from the Japan Sea floor give a constraint that the Japan Sea floor was formed at least 20 Ma. {sup 40}Ar-{sup 39}Ar ages for dyke samples from the Deccan Plateau indicate a possibility for the occurrence of a little younger ages than that of the main plateau formations by a few million years. Meteorites collected from Antarctica show some variable {sup 40}Ar-{sup 39}Ar ages reflecting their different thermal histories. (author).

  7. Experimental Probe to the Isospin-Dependent Properties of Hot Nuclei in Reactions 40Ar+112,124 Sn at 30 MeV/u

    Institute of Scientific and Technical Information of China (English)

    肖志刚; 靳根明; 吴和宇; 魏志勇; 王宏伟; 段利敏; 柳永英; 李祖玉; 张保国; 诸永泰; 王素芳; 卢朝晖; 朱海东; 胡荣江


    Protons are emitted in a greater quantity in a neutron-deficient system 40Ar+112Sn while triton emissions are greater in a neutron-rich system 40Ar+124Sn at an incident energy of 30 MeV/u. Similar to neutrons, proton emission provides a dominant contribution to neutralize the system N/Z in the decay process of the hot nuclei.The emission of hydrogen isotopes with high energies is much enhanced in the 112Sn system. The original temperature of the hot nuclei in the 40Ar+112Sn reaction is 5.8+0.3 MeV, about 0.7 MeV higher than 5.1+0.3MeV as in the 40Ar+124Sn reaction.

  8. Shuyu Capsules Relieve Premenstrual Syndrome Depression by Reducing 5-HT3AR and 5-HT3BR Expression in the Rat Brain (United States)

    Li, Fang; Feng, Jizhen; Gao, Dongmei; Wang, Jieqiong; Song, Chunhong; Wei, Sheng


    The effects of the Shuyu capsule on 5-HT3AR and 5-HT3BR expression in a rat model of premenstrual syndrome (PMS) depression and on 5-HT3AR and 5-HT3BR expression and hippocampal neuron 5-HT3 channel current were investigated, to elucidate its mechanism of action against PMS depression. PMS depression model rats were divided into depression and Shuyu- and fluoxetine-treated groups, which were compared to control rats for frontal lobe and hippocampal 5-HT3AR and 5-HT3BR expression and behavior. The depressed model rats displayed symptoms of depression, which were reduced in treated and normal control rats. Frontal lobe and hippocampal 5-HT3AR and 5-HT3BR levels were significantly higher in the model versus the control group and were significantly lower in the Shuyu group. As compared to control rats, the 5-HT3R channel current in the model group was significantly higher; the 5-HT3R channel current in hippocampal neurons treated with serum from Shuyu group rats was significantly lower than that in those treated with model group serum. Thus, PMS depression may be related to 5-HT3AR and 5-HT3BR expression and increased 5-HT3 channel current. Shuyu capsules rectified abnormal 5-HT3AR and 5-HT3BR expression and 5-HT3 channel current changes in a rat model; this finding may provide insight into treating PMS depression.

  9. Higher Education: Use of New Data Could Help Improve Oversight of Distance Education. Report to Congressional Requesters. GAO-12-39 (United States)

    Scott, George A.


    As the largest provider of financial aid in higher education, with about $134 billion in Title IV funds provided to students in fiscal year 2010, the Department of Education (Education) has a considerable interest in distance education. Distance education--that is, offering courses by the Internet, video, or other forms outside the classroom--has…

  10. Brief Report: Higher Stage of Disease is associated with Bilateral Mastectomy among Patients with Breast Cancer: A Population-Based Survey (United States)

    Freedman, Rachel A.; Kouri, Elena M.; West, Dee W.; Rosenberg, Shoshana; Partridge, Ann H.; Lii, Joyce; Keating, Nancy L.


    Background The reasons for increasing rates of bilateral mastectomy for unilateral breast cancer are incompletely understood and associations of disease stage with bilateral surgery have been inconsistent. We examined associations of clinical and sociodemographic factors, including stage, with surgery type and reconstruction receipt among women with breast cancer. Patients/Methods We surveyed a diverse population-based sample of women from northern California cancer registries with stage 0–III breast cancer diagnosed during 2010–2011 (participation rate=68.5%). Using multinomial logistic regression, we examined factors associated with bilateral and unilateral mastectomy (vs. breast conservation [BCS]), adjusting for tumor and sociodemographic characteristics. In a second model, we examined factors associated with reconstruction for mastectomy-treated patients. Results Among 487 participants, 58% had BCS, 32% had unilateral mastectomy, and 10% underwent bilateral mastectomy. In adjusted analyses, women with stage III (vs. stage 0) cancers had higher odds of bilateral mastectomy (odds ratio [O.R]=8.28; 95% Confidence Interval=2.32–29.50); women with stage II and III (vs. stage 0) disease had higher odds of unilateral mastectomy. Higher (vs. lower) income was also associated with bilateral mastectomy, while age ≥60 (vs. mastectomy-treated patients (n=206), bilateral mastectomy, unmarried status, higher education and income were all associated with reconstruction (Psmastectomy despite a lack of clear medical benefit, raising concern for over-treatment. Our findings highlight the need for interventions to assure women are making informed surgical decisions. PMID:26410475

  11. The Impact of ERASMUS on European Higher Education: Quality, Openness and Internationalisation; Final Report by the consortium of CHEPS, INCHER-Kassel and ECOTEC

    NARCIS (Netherlands)

    Vossensteyn, Johan J.; Beerkens-Soo, M.; Cremonini, Leon; Antonowitsch, Dominic; Epping, Elisabeth


    This study explores the impact of the ERASMUS programme on quality improvement in European higher education in particular in the areas of teaching, research, student services and the openness to society with a focus at the institutional and system level. The study puts an emphasis on the

  12. Energy Costs and Energy Conservation Programs in Colleges and Universities: 1972-73, 1974-75. Higher Education Panel Reports, Number 31. (United States)

    Atelsek, Frank J.; Gomberg, Irene L.

    A survey was initiated at the request of the U.S. Office of Education and the Energy Task Force to: (1) measure the increase in energy expenditures since the OPEC oil embargo of 1973-74; (2) assess changes in energy consumption over a two-year period; and (3) examine some of the specific conservation practices of higher education institutions.…

  13. 1994 AASL Research Grant Award Interim Report: The Information Search Process: A Study of Cognitive Strategies for Teaching Higher-Level Thinking Skills. (United States)

    Garland, Kathleen


    Provides a summary of a research project that is investigating how increased involvement by the library media specialist in teaching specific cognitive strategies affect students' achievement and satisfaction with their learning. Higher-level thinking skills, learning processes, students' use of information, teaching strategies, and teachers'…

  14. Higher Education: Improved Tax Information Could Help Families Pay for College. Report to the Committee on Finance, U.S. Senate. GAO-12-560 (United States)

    White, James R.; Scott, George A.


    The federal government provides billions of dollars in assistance each year to students and families through federal student aid programs authorized under Title IV of the Higher Education Act of 1965 and through tax expenditures, such as credits and deductions. GAO was asked to (1) describe the size and distribution of Title IV student aid and tax…

  15. Assessing Critical Thinking in Higher Education: Current State and Directions for Next-Generation Assessment. Research Report. ETS RR-14-10 (United States)

    Liu, Ou Lydia; Frankel, Lois; Roohr, Katrina Crotts


    Critical thinking is one of the most important skills deemed necessary for college graduates to become effective contributors in the global workforce. The first part of this article provides a comprehensive review of its definitions by major frameworks in higher education and the workforce, existing assessments and their psychometric qualities,…

  16. Planning Our Future. A Staff Background Paper on Long-Range Enrollment and Facilities Planning in California Public Higher Education. Commission Report 89-15. (United States)

    Knutsen, Kirk L.

    A background paper on long-range enrollment and facilities planning in California's public segments of higher education is designed to: (1) establish a policy framework within which the Postsecondary Education Commission can examine and assess the planning processes of the segments; and (2) describe the processes, identifying major differences…

  17. A Review of the Ford Foundation Study Titled: "State Higher Education Systems and College Completion." Research Report No. 93-06R. (United States)

    Morris, Cathy; Brann, Herman I.

    In November 1992, the Ford Foundation published a study entitled "State Higher Education Systems and College Completion," which argued that states that relied heavily on community colleges in their postsecondary educational system, such as California, Florida, Illinois, Indiana, and Wisconsin, were not efficient in producing bachelor degree (BA)…

  18. Assessing Digital Information Literacy in Higher Education: A Review of Existing Frameworks and Assessments with Recommendations for Next-Generation Assessment. Research Report. ETS RR-16-32 (United States)

    Sparks, Jesse R.; Katz, Irvin R.; Beile, Penny M.


    Digital information literacy (DIL)--generally defined as the ability to obtain, understand, evaluate, and use information in a variety of digital technology contexts--is a critically important skill deemed necessary for success in higher education as well as in the global networked economy. To determine whether college graduates possess the…

  19. Multinucleon transfer reactions in the 40Ar+208Pb system (United States)

    Mijatović, T.; Szilner, S.; Corradi, L.; Montanari, D.; Pollarolo, G.; Fioretto, E.; Gadea, A.; Goasduff, A.; Malenica, D. Jelavić; Mǎrginean, N.; Milin, M.; Montagnoli, G.; Scarlassara, F.; Soić, N.; Stefanini, A. M.; Ur, C. A.; Valiente-Dobón, J. J.


    We measured multinucleon transfer reactions in the 40Ar+208Pb system at an energy close to the Coulomb barrier, by employing the PRISMA magnetic spectrometer. We extracted differential and total cross sections of the different transfer channels, with a careful investigation of the total kinetic energy loss distributions. Comparisons between different systems having the same 208Pb target and with projectiles going from neutron-poor to neutron-rich nuclei, i.e., 40Ca, 58Ni, and 40Ar, as well as between the data and GRAZING calculations have been carried out. The neutron-rich (stable) 40Ar beam allowed us to get access to the channels involving proton pickup, whose behavior in connection with the production of neutron-rich heavy partner has been outlined.

  20. Analysis of Intensity Fluctuations of SASE using the AR Model

    CERN Document Server

    Kato, Ryukou; Isoyama, Goro; Kashiwagi, Shigeru; Okamoto, C; Suemine, Shoji; Yamamoto, Tamotsu


    We are conducting experimental study on Self-Amplified Spontaneous Emission (SASE) in the far-infrared region using the L-band linac at the Institute of Scientific and Industrial Research (ISIR), Osaka University. The intensity of SASE fluctuates intrinsically because the number of coherent optical pulses generated in an electron bunch is limited. In the actual system, however, another factor producing intensity fluctuations also shows up, which is instability of the linac. Generally speaking, it is difficult to distinguish contributions of these two factors in measured intensity fluctuations. We have applied the autoregressive (AR) model, which is one of the techniques of statistical analysis, to exclude contributions of linac instability from measured data. In the AR model, the present data can be expressed with a linear combination of the past data plus white noise. In the analysis, contributions of the linac instability are identified with the AR model and can be subtracted from the measured data of SASE,...

  1. Effects of AR Antagonist on Myocardial α1-AR Density and VERP-D after Myocardial Infarction

    Institute of Scientific and Technical Information of China (English)

    Zhang Jingmin; Wu Wei; Fang Chang; Zhang Yan; Wang Jingfeng


    Objectives To investigate the effects of adrenergic receptor antagonist ( metoprolol or prazosin) on myocardial α1-AR density and the changes of ventricular effective refractory period dispersion (VERP-D) in rabbits after myocardial infarction.Methods twenty-four adult male New Zealand rabbits were divided into four groups at random: control group ( n = 6 ); MI with placebo group ( n = 6 ); MI with metoprolol group (n = 6 ) ; MI with prazosin group (n = 6 ). The rabbits received corresponding drugs for seven days, beginning at the first day after MI and myocardial α1-AR density were measured and meanwhile, myocardial β-AR was also measured.Results In the placebo group, the density of ventricular α1-AR was increased in comparison with control group ( α1 -AR in normal region 36.9 ± 0.2 vs 27.3 ±0.9 fmol mg-1 Pro-1 ,p <0.01; α1-AR in ischemic region 33.0±0.9 vs 26.6 ±0.4 fmol mg-1 pro-1 P <0.01). In the metoprolol group, it was also increased in comparison with control group( α1-AR in normal region 44.7 ±1.5 vs 27.3 ±0.9 fmol mg-1 pro-1 ,P <0.01; α1-AR in ischemic region 33.6 ± 0.5 vs 26.6 ± 0.4 fmol mg-1pro-1 , P < 0.01 ). Meanwhile the density of ventricular α1-AR in normal region in the metoprolol group was increased in comparison with placebo group (44.7 ±1.5 vs 36.9 ±0.2 fmol mg-1 pro-1,P<0.01). While it decreased in the prazosin group in comparison with control group ( α1-AR in normal region 22.5 ± 0.6 vs27.3 ±0.9 fmol mg-1pro-1 ,P <0.01; α1-AR in ischemic region 20.9 ±0.4 vs 26.6 ±0.4 fmol mg-1 pro-1,P <0.01 ). VERP-D was increased after MI(P <0.01 ).After treatment with metoprolol or prazosin, VERP-D was decreased ( P < 0.01 ). Conclusions After acute MI, α1-AR of ventricular myocardium was upregulated, which may be accompanied by its activitation.The density of myocardial α1-AR became upregulated more dramatically treated with metoprolol and downregulated with prazosin. When treated with metoprolol or prazosin

  2. Defect production in Ar irradiated graphene membranes under different initial applied strains

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Asencio, J., E-mail: [Dept. Física Aplicada, Facultad de Ciencias, Fase II, Universidad de Alicante, Alicante E-036090 (Spain); Ruestes, C.J.; Bringa, E. [CONICET and Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, Mendoza 5500 (Argentina); Caturla, M.J. [Dept. Física Aplicada, Facultad de Ciencias, Fase II, Universidad de Alicante, Alicante E-036090 (Spain)


    Highlights: • Defects in graphene membranes are formed due to 140 eV Ar ions irradiation using MD. • Different initial strains are applied, which influence the type and number of defects. • Mono-vacancies, di-vacancies and tri-vacancies production behaves linearly with dose. • The total number of defects under compression is slightly higher than under tension. - Abstract: Irradiation with low energy Ar ions of graphene membranes gives rise to changes in the mechanical properties of this material. These changes have been associated to the production of defects, mostly isolated vacancies. However, the initial state of the graphene membrane can also affect its mechanical response. Using molecular dynamics simulations we have studied defect production in graphene membranes irradiated with 140 eV Ar ions up to a dose of 0.075 × 10{sup 14} ions/cm{sup 2} and different initial strains, from −0.25% (compressive strain) to 0.25% (tensile strain). For all strains, the number of defects increases linearly with dose with a defect production of about 80% (80 defects every 100 ions). Defects are mostly single vacancies and di-vacancies, although some higher order clusters are also observed. Two different types of di-vacancies have been identified, the most common one being two vacancies at first nearest neighbours distance. Differences in the total number of defects with the applied strain are observed which is related to the production of a higher number of di-vacancies under compressive strain compared to tensile strain. We attribute this effect to the larger out-of-plane deformations of compressed samples that could favor the production of defects in closer proximity to others.

  3. A model for meteoritic and lunar 40Ar/39Ar age spectra: Addressing the conundrum of multi-activation energies (United States)

    Boehnke, P.; Harrison, T. Mark; Heizler, M. T.; Warren, P. H.


    Results of whole-rock 40Ar/39Ar step-heating analyses of extra-terrestrial materials have been used to constrain the timing of impacts in the inner solar system, solidification of the lunar magma ocean, and development of planetary magnetic fields. Despite the importance of understanding these events, the samples we have in hand are non-ideal due to mixed provenance, isotopic disturbances from potentially multiple heating episodes, and laboratory artifacts such as nuclear recoil. Although models to quantitatively assess multi-domain, diffusive 40Ar* loss have long been applied to terrestrial samples, their use on extra-terrestrial materials has been limited. Here we introduce a multi-activation energy, multi-diffusion domain model and apply it to 40Ar/39Ar temperature-cycling, step-heating data for meteoritic and lunar samples. We show that age spectra of extra-terrestrial materials, the Jilin chondrite (K-4) and Apollo 16 lunar breccia (67514 , 43), yielding seemingly non-ideal behavior commonly interpreted as either laboratory artifacts or localized shock heating of pyroxene, are meaningful and can be understood in context of the presence of multi-diffusion domains containing multiple activation energies. Internally consistent results from both the meteoritic and lunar samples reveal high-temperature/short duration thermal episodes we interpret as due to moderate shock heating.

  4. Development of a low-level Ar-37 calibration standard

    CERN Document Server

    Williams, R M; Bowyer, T W; Day, A R; Fuller, E S; Haas, D A; Hayes, J C; Hoppe, E W; Humble, P H; Keillor, M E; LaFerriere, B D; Mace, E K; McIntyre, J I; Miley, H S; Myers, A W; Orrell, J L; Overman, C T; Panisko, M E; Seifert, A


    Argon-37 is an environmental signature of an underground nuclear explosion. Producing and quantifying low-level Ar-37 standards is an important step in the development of sensitive field measurement instruments. This paper describes progress at Pacific Northwest National Laboratory in developing a process to generate and quantify low-level Ar-37 standards, which can be used to calibrate sensitive field systems at activities consistent with soil background levels. This paper presents a discussion of the measurement analysis, along with assumptions and uncertainty estimates.

  5. Adsorption of Ar on a nonuniform MgO surface (United States)

    Hinman, D. C.; Halsey, G. D.


    Data are presented for the adsorption of Ar and N2 on a strongly heterogeneous MgO surface at 84 K and for Ar at a range of temperatures between 130 and 250 K. The high-temperature data are analyzed according to a model which separates the contributions to the potential into bulk and surface terms, providing a method for the determination of the surface area from parameters characteristic of the bulk material. A solid-gas energy parameter and parameters indicating the strength of the impurity sites are also evaluated.

  6. Interatomic scattering in energy dependent photoelectron spectra of Ar clusters

    Energy Technology Data Exchange (ETDEWEB)

    Patanen, M.; Benkoula, S.; Nicolas, C.; Goel, A. [Synchrotron SOLEIL, L’Orme des Merisiers, Saint-Aubin, BP 48, 91192 Gif-sur-Yvette Cedex (France); Antonsson, E. [Synchrotron SOLEIL, L’Orme des Merisiers, Saint-Aubin, BP 48, 91192 Gif-sur-Yvette Cedex (France); Physikalische und Theoretische Chemie Institut für Chemie und Biochemie, Fachbereich Biologie, Chemie, Pharmazie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin (Germany); Neville, J. J. [Synchrotron SOLEIL, L’Orme des Merisiers, Saint-Aubin, BP 48, 91192 Gif-sur-Yvette Cedex (France); Department of Chemistry, University of New Brunswick, Fredericton, New Brunswick E3B 6E2 (Canada); Miron, C., E-mail: [Synchrotron SOLEIL, L’Orme des Merisiers, Saint-Aubin, BP 48, 91192 Gif-sur-Yvette Cedex (France); Extreme Light Infrastructure - Nuclear Physics (ELI-NP), ‘Horia Hulubei’ National Institute for Physics and Nuclear Engineering, 30 Reactorului Street, RO-077125 Măgurele, Jud. Ilfov (Romania)


    Soft X-ray photoelectron spectra of Ar 2p levels of atomic argon and argon clusters are recorded over an extended range of photon energies. The Ar 2p intensity ratios between atomic argon and clusters’ surface and bulk components reveal oscillations similar to photoelectron extended X-ray absorption fine structure signal (PEXAFS). We demonstrate here that this technique allows us to analyze separately the PEXAFS signals from surface and bulk sites of free-standing, neutral clusters, revealing a bond contraction at the surface.

  7. β-delayed Multi-particle Emission From 31Ar

    Institute of Scientific and Technical Information of China (English)

    A. A. Ciemny; J. Du´enas-Daz; V. Dunin; J. M. Espino; A. Estrade; F. Farinon; A. Fomichev; H. Geisse; A. Gorshkov; G. Kami´nski; O. Kiselev; C. Mazzocchi; R. Kn¨obe; S. Krupko; M. Kuich; Yu. A. Litvinov; G. Marquinez-Dur´an; I. Martel; I. Mukha; C. Nociforo; A. K. Ord´uz; S. Pietri; W. Dominik; A. Prochazka; A. M. S´anchez-Ben´ıtez; H. Simon; B. Sitar; R. Slepnev; M. Stanoiu; P. Strmen; I. Szarka; M. Takechi; Y. Tanaka; Z. Janas; H. Weick; J. S. Winfield; M. Pf¨utzner; M. Pomorski; L. Acosta; S. Baraeva; E. Casarejos


    The β+ decay of 31Ar was investigated in an experiment at the GSI-FRS spectrometer. The ions of interest have been produced in the fragmentation of a 36Ar beam at 880 MeV/nucleon and implanted in a time projection chamber with optical readout. In addition to β-delayed one and two proton emission, for the first time the emission ofβ-delayed 3 protons has been observed. The branching ratio for this decay mode is found to be (0.07 ± 0.02)%.

  8. Carbon dioxide and the stomatal control of water balance and photosynthesis in higher plants. Progress report, July 1, 1990--June 30, 1992

    Energy Technology Data Exchange (ETDEWEB)


    Research continued into the investigation of the effects of carbon dioxide on stomatal control of water balance and photosynthesis in higher plants. Topics discussed this period include a method of isolating a sufficient number of guard cell chloroplasts for biochemical studies by mechanical isolation of epidermal peels; the measurement of stomatal apertures with a digital image analysis system; development of a high performance liquid chromatography method for quantification of metabolites in guard cells; and genetic control of stomatal movements in Pima cotton. (CBS)

  9. Transcriptional and posttranscriptional regulation of Bacillus sp. CDB3 arsenic-resistance operon ars1

    Directory of Open Access Journals (Sweden)

    Xuefei Yu


    Full Text Available Bacillus sp. CDB3 possesses a novel eight-gene ars cluster (ars1, arsRYCDATorf7orf8 with some unusual features in regard to expression regulation. This study demonstrated that the cluster is a single operon but can also produce a short three-gene arsRYC transcript. A hairpin structure formed by internal inverted repeats between arsC and arsD was shown to diminish the expression of the full operon, thereby probably acting as a transcription attenuator. A degradation product of the arsRYC transcript was also identified. Electrophoretic mobility shift analysis demonstrated that ArsR interacts with the ars1 promoter forming a protein-DNA complex that could be impaired by arsenite. However, no interaction was detected between ArsD and the ars1 promoter, suggesting that the CDB3 ArsD protein may not play a regulatory role. Compared to other ars gene clusters, regulation of the Bacillus sp. CDB3 ars1 operon is more complex. It represents another example of specific mRNA degradation in the transporter gene region and possibly the first case of attenuator-mediated regulation of ars operons.

  10. Thermal plasma properties for Ar-Al, Ar-Fe and Ar-Cu mixtures used in welding plasmas processes: I. Net emission coefficients at atmospheric pressure (United States)

    Cressault, Y.; Gleizes, A.


    This article is devoted to the calculation of the net emission coefficient (NEC) of Ar-Al, Ar-Fe and Ar-Cu mixtures at atmospheric pressure for arc welding processes. The results are given in data tables for temperatures between 3 kK and 30 kK, for five plasma thicknesses (0, 0.5, 1, 2, 5 mm) and ten concentrations of metallic vapours (pure gas, 0.01%, 0.1%, 1%, 5%, 10%, 25%, 50%, 75% and pure metal vapours in mass proportions). The results are in good agreement with most of the works published on the subject for such mixtures. They highlight the influence of three parameters on the radiation of the plasma: the NEC is directly related to temperature and inversely related to plasma radius and is highly sensitive to the presence of metal vapours. Finally, numerical data are supplied in tables in order to develop accurate computational modelling of welding arc and to estimate both qualitatively and quantitatively the influence of each metallic vapour on the size and on the shape of the weld pool.

  11. Comparative evaluation of the IPCC AR5 CMIP5 versus the AR4 CMIP3 model ensembles for regional precipitation and their extremes over South America (United States)

    Tolen, J.; Kodra, E. A.; Ganguly, A. R.


    The assertion that higher-resolution experiments or more sophisticated process models within the IPCC AR5 CMIP5 suite of global climate model ensembles improves precipitation projections over the IPCC AR4 CMIP3 suite remains a hypothesis that needs to be rigorously tested. The questions are particularly important for local to regional assessments at scales relevant for the management of critical infrastructures and key resources, particularly for the attributes of sever precipitation events, for example, the intensity, frequency and duration of extreme precipitation. Our case study is South America, where precipitation and their extremes play a central role in sustaining natural, built and human systems. To test the hypothesis that CMIP5 improves over CMIP3 in this regard, spatial and temporal measures of prediction skill are constructed and computed by comparing climate model hindcasts with the NCEP-II reanalysis data, considered here as surrogate observations, for the entire globe and for South America. In addition, gridded precipitation observations over South America based on rain gage measurements are considered. The results suggest that the utility of the next-generation of global climate models over the current generation needs to be carefully evaluated on a case-by-case basis before communicating to resource managers and policy makers.

  12. Alignment of Ar+ Ions Produced After Resonant Auger Decay of Ar* 2p5 3d Resonances (United States)

    Meyer, M.; Marquette, A.; Grum-Grzhimailo, A.; Flesch, R.; Rühl, E.

    Fluorescence spectra have been recorded in the wavelength region 300 nm fluo) 3d excitation of atomic Ar using monochromatic synchrotron light. The radiative emission is characterized by strong transitions from Ar+ 3p4 (1S, 1D, 3P) nl ionic states. It is mainly assigned to processes of the type 3p4 4d --> 3p4 4p and 3p4 4p --> 3p4 4s. In addition, we have analyzed the degree of polarization of the fluorescence lines and we have determined the alignment of the Ar+ ions, which are produced after the resonant Auger decay. In comparison to investigations based on photoelectron spectroscopy, the spectral analysis of the fluorescence provides complementary information about the electronic relaxation during the resonant Auger process and, in particular, it allows one to examine directly the remaining ion.

  13. Fiscal Profiles, 2010: The Seventeenth in a Series of Factbooks about the Financing of California Higher Education. Report 10-22 (United States)

    California Postsecondary Education Commission, 2010


    This report contains and analyzes statistical information about the financing of California postsecondary education from the 1965-66 fiscal year through 2010-11. CPEC (California Postsecondary Education Commission) compiles, analyzes, and disseminates this information to provide policymakers with comprehensive and comparable financial data that…

  14. Distance Education in European Higher Education--The Potential. Report 3 (of 3) of the IDEAL (Impact of Distance Education on Adult Learning Project. Extended Version (United States)

    Owusu-Boampong, Angela; Holmberg, Carl


    This report is the third in a series published by the IDEAL (Impact of Distance Education on Adult Learning) project. The IDEAL project ran from October 2013 to September 2015 with financial support from the EU Lifelong Learning Programme. The project aims to: (1) offer insights on the needs of adult learners to both policymakers and distance…

  15. Distance Education in European Higher Education--The Students. Report 2 (of 3) of the IDEAL (Impact of Distance Education on Adult Learning) Project (United States)

    Schneller, Chripa; Holmberg, Carl


    This report is the second in a series published by the IDEAL (Impact of Distance Education on Adult Learning) project. The IDEAL project ran from October 2013 to September 2015 with financial support from the EU Lifelong Learning Programme. The project aims to: (1) offer insights on the needs of adult learners to both policymakers and distance…

  16. Distance Education in European Higher Education--The Offer. Report 1 (of 3) of the IDEAL (Impact of Distance Education on Adult Learning) Project (United States)

    Schneller, Chripa; Holmberg, Carl


    This report is the first in a series published by the IDEAL (Impact of Distance Education on Adult Learning) project. The IDEAL project ran from October 2013 to September 2015 with financial support from the EU Lifelong Learning Programme. The project aims to: (1) offer insights on the needs of adult learners to both policymakers and distance…

  17. Report of the Task Force on Student Financial Aid. Expanding Opportunities for Higher Education for the Commonwealth: Quality, Access, and Choice [with] Recommendations of Chancellor Franklyn G. Jenifer. (United States)

    Massachusetts State Board of Regents of Higher Education, Boston.

    The Task Force on Student Financial Aid was formed to recommend ways in which Massachusetts' student aid programs might be modified in light of nationwide trends of rising college costs, reduced availability of federal student assistance, and a decline in the ability of many families to pay for college. The first chapter of the task force report,…

  18. Student Loans in Higher Education: 2. Asia. Report of an IIEP Educational Forum. IIEP Dissemination Programme, Educational Forum Series, No. 2. (United States)

    Woodhall, Maureen

    This report summarizes an educational forum organized by the International Institute for Educational Planning (IIEP) and held in Genting, Malaysia on November 6-8, 1990, to discuss the experience of student loans in Australia, the People's Republic of China, Hong Kong, India, Indonesia, Japan, Malaysia, the Philippines, Singapore, and Thailand. In…

  19. Characterization of the ars Gene Cluster from Extremely Arsenic-Resistant Microbacterium sp. Strain A33▿ † (United States)

    Achour-Rokbani, Asma; Cordi, Audrey; Poupin, Pascal; Bauda, Pascale; Billard, Patrick


    The arsenic resistance gene cluster of Microbacterium sp. A33 contains a novel pair of genes (arsTX) encoding a thioredoxin system that are cotranscribed with an unusual arsRC2 fusion gene, ACR3, and arsC1 in an operon divergent from arsC3. The whole ars gene cluster is required to complement an Escherichia coli ars mutant. ArsRC2 negatively regulates the expression of the pentacistronic operon. ArsC1 and ArsC3 are related to thioredoxin-dependent arsenate reductases; however, ArsC3 lacks the two distal catalytic cysteine residues of this class of enzymes. PMID:19966021

  20. Harmonic-seeded remote laser emissions in N2-Ar, N2-Xe and N2-Ne mixtures: a comparative study

    CERN Document Server

    Ni, Jielei; Zhang, Haisu; Jing, Chenrui; Yao, Jinping; Xu, Huailiang; Zeng, Bin; Li, Guihua; Zhang, Chaojin; Chin, See Leang; Cheng, Ya; Xu, Zhizhan


    We report on the investigation on harmonic-seeded remote laser emissions at 391 nm wavelength from strong-field ionized nitrogen molecules in three different gas mixtures, i.e., N2-Ar, N2-Xe and N2-Ne. We observed a decrease in the remote laser intensity in the N2-Xe mixture because of the decreased clamped intensity in the filament; whereas in the N2-Ne mixture, the remote laser intensity slightly increases because of the increased clamped intensity within the filament. Remarkably, although the clamped intensity in the filament remains nearly unchanged in the N2-Ar mixture because of the similar ionization potentials of N2 and Ar, a significant enhancement of the lasing emission is realized in the N2-Ar mixture. The enhancement is attributed to the stronger third harmonic seed, and longer gain medium due to the extended filament.

  1. Higher Education: An International Perspective. (United States)

    Phelps, Richard P.; Dietrich, Greta L.; Phillips, Gabriele; McCormack, Kevin A.

    This report provides a review of higher education systems in selected developed countries and compares higher education in the United States and other countries. The report draws on data from the Indicators of National Education Systems Project of the Centre for Educational Research and Innovation (CERI) of the Organisation for Economic…

  2. Alu Sx repeat-induced homozygous deletion of the StAR gene causes lipoid congenital adrenal hyperplasia. (United States)

    Eiden-Plach, Antje; Nguyen, Huy-Hoang; Schneider, Ursula; Hartmann, Michaela F; Bernhardt, Rita; Hannemann, Frank; Wudy, Stefan A


    Lipoid congenital adrenal hyperplasia (Lipoid CAH) is the most severe form of the autosomal recessive disorder CAH. A general loss of the steroid biosynthetic activity caused by defects in the StAR gene manifests as life-threatening primary adrenal insufficiency. We report a case of Lipoid CAH caused by a so far not described homozygous deletion of the complete StAR gene and provide diagnostic results based on a GC-MS steroid metabolomics and molecular genetic analysis. The patient presented with postnatal hypoglycemia, vomiting, adynamia, increasing pigmentation and hyponatremia. The constellation of urinary steroid metabolites suggested Lipoid CAH and ruled out all other forms of CAH or defects of aldosterone biosynthesis. After treatment with sodium supplementation, hydrocortisone and fludrocortisone the child fully recovered. Molecular genetic analysis demonstrated a homozygous 12.1 kb deletion in the StAR gene locus. The breakpoints of the deletion are embedded into two typical genomic repetitive Alu Sx elements upstream and downstream of the gene leading to the loss of all exons and regulatory elements. We established deletion-specific and intact allele-specific PCR methods and determined the StAR gene status of all available family members over three generations. This analysis revealed that one of the siblings, who died a few weeks after birth, carried the same genetic defect. Since several Alu repeats at the StAR gene locus increase the probability of deletions, patients with typical symptoms of lipoid CAH lacking evidence for the presence of both StAR alleles should be analyzed carefully for this kind of disorder.

  3. Thermal History of the Felsite Unit, Geysers Geothermal Field, From Thermal Modeling of 40Ar/39Ar Incremental Heating Data

    Energy Technology Data Exchange (ETDEWEB)

    T. M. Harrison (U of California); G. B. Dalrymple (Oregon State U); J. B. Hulen (U of Utah); M. A. Lanphere; M. Grove; O. M. Lovera


    An Ar-40/Ar-39 and U-Pb study was performed of the Geysers plutonic complex of the Geysers Geothermal Field in California. Sixty-nine ion microprobe spot analyses of zircons from four granite samples from the plutonic complex that underlies the Geysers geothermal field yielded Pb-207/Pb-206 vs. U-238/Pb-206 concordia ages ranging from 1.13 {+-} 0.04 Ma to 1.25 {+-} 0.04 Ma. The U-Pb ages coincide closely with Ar-40/Ar-39 age spectrum plateau and ''terminal'' ages from coexisting K-feldspars and with the eruption ages of overlying volcanic rocks. The data indicate that the granite crystallized at 1.18 Ma and had cooled below 350 C by {approximately}0.9-1.0 Ma. Interpretation of the feldspar Ar-40/Ar-39 age data using multi-diffusion domain theory indicates that post-emplacement rapid cooling was succeeded either by slower cooling from 350-300 C between 1.0 and 0.4 Ma or transitory reheating to 300-350 C at about 0.4-0.6 Ma. Heat flow calculations constrained with K-feldspar thermal histories and the pre sent elevated regional heal flow anomaly demonstrate that appreciable heat input from sources external to the known Geysers plutonic complex is required to maintain the geothermal system. This requirement is satisfied by either a large, underlying, convecting magma chamber (now solidified) emplaced at 1.2 Ma or episodic intrusion of smaller bodies from 1.2-0.6 Ma.

  4. Late Paleozoic deformation and exhumation in the Sierras Pampeanas (Argentina): 40Ar/39Ar-feldspar dating constraints (United States)

    Löbens, Stefan; Oriolo, Sebastián; Benowitz, Jeff; Wemmer, Klaus; Layer, Paul; Siegesmund, Siegfried


    Systematic 40Ar/39Ar feldspar data obtained from the Sierras Pampeanas are presented, filling the gap between available high- (>~300 °C) and low-temperature (Pie de Palo regions, whereas the Sierras de San Luis and the Sierra de Comechingones regions record exhumation during the Carboniferous. Comparison between new and available data points to a Carboniferous tectonic event in the Sierras Pampeanas, which represents a key period to constrain the early evolution of the proto-Andean margin of Gondwana. This event was probably transtensional and played a major role during the evolution of the Paganzo Basin as well as during the emplacement of alkaline magmatism in the retroarc.

  5. Shock tube study of the reaction H plus O2 plus Ar yields HO2 plus Ar (United States)

    Jachimowski, C. J.; Houghton, W. M.


    Rate coefficient data for the recombination reaction H + 02 + Ar yields H02 + Ar have been determined from studies of lean hydrogen-oxygen mixtures behind incident shock waves over the temperature range of 948 to 1125 K. Hydroxyl radical concentration profiles were measured by ultraviolet absorption spectroscopy, and rate data were obtained through analysis of induction time and exponential growth parameter data. Analysis of the data yielded a rate coefficient which was generally lower than most of the more recent values obtained from shock tube studies. The effect of boundary layer formation on the conditions behind the shock was also examined and found to be negligible.

  6. Vector Magnetic Field Measurement of NOAA AR 10197

    Institute of Scientific and Technical Information of China (English)

    Hong-Fei Liang; Hai-Juan Zhao; Fu-Yuan Xiang


    A set of two-dimensional Stokes spectral data of NOAA AR 10197 obtained by the Solar Stokes Spectral Telescope (S3T) at the Yunnan Observatory are qualitatively analyzed.The three components of the vector magnetic field, the strength H, inclination γ and azimuth x, are derived. Based on the three components, we contour the distributions of the longitudinal magnetic field and transverse magnetic field. The active region (AR) has two different magnetic polarities apparent in the longitudinal magnetic map due to projection effect. There is a basic agreement on the longitudinal magnetic fields between the S3T and SOHO/MDI magnetograms, with a correlation coefficient ρBl = 0.911. The transverse magnetic field of the AR has a radial distribution from a center located in the southwest of the AR. It is also found that the transverse magnetic fields obtained by Huairou Solar Observing Station (HRSOS) have a similar radial distribution. The distributions of transverse magnetic field obtained by S3T and HRSOS have correlation coefficients, ρAzimu = 0.86 and ρBt = 0.883,in regard to the azimuthal angle and intensity.

  7. Pulsed electric field (PEF)research at USDA, ARS, ERRC (United States)

    This article summarizes the effects of pulsed electric fields on the microbiological safety and quality aspects of various liquid food matrices, obtained at USDA, ARS, Eastern Regional Research Center under CRIS Project No. 1935-41420-013-00D, Processing Intervention Technologies for Enhancing the S...

  8. Analizando las intenciones profundas del "Ars poetica" de Horacio

    Directory of Open Access Journals (Sweden)

    Óscar Velásquez


    Full Text Available El "Arte Poética" de Horacio ha sido interpretada muy diversamente, pero es conveniente tener en cuenta su estilo epistolar, que la distancia a la vez del tratado de tipo filosófico y de la libertad de la sátira. Se propone en este estudio que de todos modos el AP es una obra que se articula en base a una idea fundamental, a saber, la de "forma", de la que surgen los conceptos de 'materia temática' y 'acción', especialmente la épica y el drama. El amplio espacio, por otra parte, concedido al arte, como sería natural en una poética,se debería explicar por el hecho de que el "ars" es de un cierto modo la "forma" que da realidad al verdadero poeta. (Horace's "Ars Poetica" has been interpreted in many ways, but it is important to consider its epistolary style, which sets it apart from the philosophical essay and from the free-style satyre. This study proposes that "Ars Poetica" is articulated upon a fundamental notion, that of "form", from which the concepts of 'thematic matter' and 'action' emerge, especially epic and drama. The relevance given to art, on the other hand, is explained by the fact that "ars" is somehow the "form" that shapes the real poet.


    NARCIS (Netherlands)



    A canonical form for AR 2-D systems representations is introduced. This yields a method for computing the system trajectories by means of a line-by-line recursion, and displays some relevant information about the system structure such as the choice of inputs and initial conditions.

  10. Interacting with Visual Poems through AR-Based Digital Artwork (United States)

    Lin, Hao-Chiang Koong; Hsieh, Min-Chai; Liu, Eric Zhi-Feng; Chuang, Tsung-Yen


    In this study, an AR-based digital artwork called "Mind Log" was designed and evaluated. The augmented reality technique was employed to create digital artwork that would present interactive poems. A digital poem was generated via the interplay between a video film and a text-based poem. This artwork was created following a rigorous design flow,…

  11. Global properties of the white dwarf pulsar AR Scorpii

    CERN Document Server

    Franzon, B


    In view of the new recent observation and measurement of the fast-rotating and highly-magnetized white dwarf AR Sco \\cite{Marsh:2016uhc}, we determine bounds for its radius, magnetic fields, moment of inertia and gravitational wave (GW) emission by using observations of the luminosity, as well the rotation frequency $\

  12. Big data computing: Building a vision for ARS information management (United States)

    Improvements are needed within the ARS to increase scientific capacity and keep pace with new developments in computer technologies that support data acquisition and analysis. Enhancements in computing power and IT infrastructure are needed to provide scientists better access to high performance com...

  13. Professor Oberth and Dr. von Braun at ARS Banquet (United States)


    Dr. Wernher von Braun holds the coveted Hermarn Oberth award presented to him by Professor Oberth during the banquet hosted by the Alabama Section of the American Rocket Society (ARS), on October 19, 1961. The Oberth award was given for outstanding technical contributions to the field of astronautics or for the promotion and advancement of astronautical sciences.

  14. Electron Scattering by Ar Atoms in a Laser Field

    Institute of Scientific and Technical Information of China (English)

    ZHANG Sheng-Hai; QIAN Xing-Zhong; JIANG Yu-Hai; SUN Jin-Feng


    The differentialcross sections of electron-Ar atom scattering for free-free transition with one and two photons absorption in the presence of CO2 laser field is obtained by the second Born approximation, the direction of laser polarization being perpendicular to the change of electron momentum. Compared with the more recent available experimental data, the present results are very good.

  15. Mälestusi "Ars Fennica'st" / Eha Komissarov

    Index Scriptorium Estoniae

    Komissarov, Eha, 1947-


    Ars Fennica 2008. aasta nominentide Tea Mäkipää, Seppo Renvalli, Maria Dunckeri, Katrīna Neiburga (Läti) ja Mark Raidpere näitus Kumu Kunstimuuseumis 26. aprillini. Preemiaga pärjati Mark Raidpere ekspositsioon

  16. Ars Fennica - isikliku ja poliitilise vahel / Janar Ala

    Index Scriptorium Estoniae

    Ala, Janar, 1979-


    2008. aasta Ars Fennica kunstiauhinna kandidaatide tööde näitus Kumu Kunstimuuseumis kuni 26. aprillini. Läti kunstniku Katrina Neiburga, soomlaste Seppo Renvalli, Maria Dunckeri ja Tea Mäkipää ning Mark Raidpere näitusel eksponeeritud töödest

  17. Mälestusi "Ars Fennica'st" / Eha Komissarov

    Index Scriptorium Estoniae

    Komissarov, Eha, 1947-


    Ars Fennica 2008. aasta nominentide Tea Mäkipää, Seppo Renvalli, Maria Dunckeri, Katrīna Neiburga (Läti) ja Mark Raidpere näitus Kumu Kunstimuuseumis 26. aprillini. Preemiaga pärjati Mark Raidpere ekspositsioon

  18. Near-contact Binaries IZ Monocerotis and AR Draconis (United States)

    Yang, Yuan-Gui; Dai, Hai-Feng; Zhou, Zheng; Li, Qun


    We present multi-color photometric observations for two neglected near-contact binaries, IZ Mon (P=0\\_\\_AMP\\_\\_fd;77980) and AR Dra (P=0\\_\\_AMP\\_\\_fd;67584). By the aid of the updated W-D analysis code, the photometric solutions were deduced from the multi-color light curves (LCs). IZ Mon is a semi-detached binary with a mass ratio of q=0.388(+/- 0.002), while AR Dra is a detached star with a mass ratio of q=0.652(+/- 0.002). The asymmetric LCs of IZ Mon were modeled by a hot spot on the secondary’s surface, which may be attributed to mass transfer from the primary. Based on all collected eclipse times for two systems, we constructed their timing residual curves. The orbital period for IZ Mon may be continuously decreasing at a rate of {dP}/{dt}=-2.06(+/- 0.04) {days} {{yr}}-1, which may result from mass and angular momentum loss from the central system. For AR Dra, there exists a cyclic variation with a period of {P}3=104.9(+/- 2.9) {yr} due to light-time orbit effect via the presence of the third body, whose mass is more than 0.28(+/- 0.02) {M}⊙ . Finally, two near-contact binaries, IZ Mon and AR Dra, will evolve into contact binaries.

  19. Multi-particle emission in the decay of $^{31}$Ar

    CERN Document Server

    Koldste, G T; Borge, M.J.G.; Briz, J.A.; Carmona-Gallardo, M.; Fraile, L.M.; Fynbo, H.O.U.; Giovinazzo, J.; Grann, B.D.; Johansen, J.G.; Jokinen, A.; Jonson, B.; Kurturkian-Nieto, T.; Kusk, J.H.; Nilsson, T.; Perea, A.; Pesudo, V.; Picado, E.; Riisager, K.; Saastamoinen, A.; Tengblad, O.; Thomas, J.C.; Van de Walle, J.


    A multi-hit capacity setup was used to study the decay of the dripline nucleus 31Ar, produced at the ISOLDE facility at CERN. A spectroscopic analysis of the beta-delayed three-proton decay of 31Ar is presented for the first time together with a quantitative analysis of the beta-delayed two-proton-gamma-decay. A new method for determination of the spin of low-lying levels in the beta-proton-daughter 30S using proton-proton angular correlations is presented and used for the level at 5.2 MeV, which is found to be either a 3+ or 4+ level, with the data pointing towards the 3+. The half-life of 31Ar is found to be 15.1(3) ms. An improved analysis of the Fermi beta-strength gives a total measured branching for the beta-3p-decay of 3.60(44) %, which is lower than the theoretical value found to be 4.24(43) %. Finally the strongest gamma-transitions in the decay of 33Ar are shown including a line at 4734(3) keV associated to the decay of the IAS, which has not previously been identified.

  20. The ARS Culture Collection and Developments in Biotechnology (United States)

    The ARS Culture Collection (NRRL) has played a prominent role in the development of biotechnology since its founding in 1940 when the Northern Regional Research Laboratory opened. Early discoveries included selection of production strains for penicillin, dextran blood extender, xanthan gum and the v...