WorldWideScience

Sample records for reported compromised integrity

  1. Towards a legitimate compromise?: An exploration of Integrated Reporting in the Netherlands

    NARCIS (Netherlands)

    van Bommel, K.

    2014-01-01

    Purpose – The purpose of this paper is to examine the multiplicity of views on integrated reporting and to consider the possibility of, and impediments to, reconciling these multiple rationales (“orders of worth”) and thus gain legitimacy through a compromise. This sheds light on the understanding

  2. Sustained NMDA receptor hypofunction induces compromised neural systems integration and schizophrenia-like alterations in functional brain networks.

    Science.gov (United States)

    Dawson, Neil; Xiao, Xiaolin; McDonald, Martin; Higham, Desmond J; Morris, Brian J; Pratt, Judith A

    2014-02-01

    Compromised functional integration between cerebral subsystems and dysfunctional brain network organization may underlie the neurocognitive deficits seen in psychiatric disorders. Applying topological measures from network science to brain imaging data allows the quantification of complex brain network connectivity. While this approach has recently been used to further elucidate the nature of brain dysfunction in schizophrenia, the value of applying this approach in preclinical models of psychiatric disease has not been recognized. For the first time, we apply both established and recently derived algorithms from network science (graph theory) to functional brain imaging data from rats treated subchronically with the N-methyl-D-aspartic acid (NMDA) receptor antagonist phencyclidine (PCP). We show that subchronic PCP treatment induces alterations in the global properties of functional brain networks akin to those reported in schizophrenia. Furthermore, we show that subchronic PCP treatment induces compromised functional integration between distributed neural systems, including between the prefrontal cortex and hippocampus, that have established roles in cognition through, in part, the promotion of thalamic dysconnectivity. We also show that subchronic PCP treatment promotes the functional disintegration of discrete cerebral subsystems and also alters the connectivity of neurotransmitter systems strongly implicated in schizophrenia. Therefore, we propose that sustained NMDA receptor hypofunction contributes to the pathophysiology of dysfunctional brain network organization in schizophrenia.

  3. Pulmonary, neurological and hepatic compromise in paragonimiasis: case report

    International Nuclear Information System (INIS)

    Uriza Carrasco, Alfonso Jose; Cuervo Valencia, Catalina; Valencia M, Andres Mauricio; Echeverri Toro, Lina Maria

    2011-01-01

    Paragonimiasis is a parasitic infectious disease, frequently with pulmonary abnormalities, although erratic parasite migration can compromise other organs. this disease is endemic in areas of southeast Asia, but it has been described in other tropical and subtropical regions. In this article, we report a case of indigenous patient with pulmonary abnormalities by Paragonimiasis, neurologic and hepatic abnormalities too.

  4. Fibre reinforcement in a structurally compromised endodontically treated molar: a case report

    Directory of Open Access Journals (Sweden)

    Renita Soares

    2016-05-01

    Full Text Available The reconstruction of structurally compromised posterior teeth is a rather challenging procedure. The tendency of endodontically treated teeth (ETT to fracture is considerably higher than vital teeth. Although posts and core build-ups followed by conventional crowns have been generally employed for the purpose of reconstruction, this procedure entails sacrificing a considerable amount of residual sound enamel and dentin. This has drawn the attention of researchers to fibre reinforcement. Fibre-reinforced composite (FRC, designed to replace dentin, enables the biomimetic restoration of teeth. Besides improving the strength of the restoration, the incorporation of glass fibres into composite resins leads to favorable fracture patterns because the fibre layer acts as a stress breaker and stops crack propagation. The following case report presents a technique for reinforcing a badly broken-down ETT with biomimetic materials and FRC. The proper utilization of FRC in structurally compromised teeth can be considered to be an economical and practical measure that may obviate the use of extensive prosthetic treatment.

  5. National Report presented by the Mexican United States to satisfy the compromises of the Nuclear Safety Convention

    International Nuclear Information System (INIS)

    1998-01-01

    In order to satisfy to the compromises derived of the ratification by part of the Mexican Government for the Nuclear Safety Convention it is presented this National Report which is based on the directives proposed as a result of the preparatory meetings held in the IAEA Headquarters in the city of Vienna, Austria. This National Report represents a document summary and activities realized at present in relation with the only nuclear facility in Mexico: the Nuclear Power Plant in Laguna Verde, Veracruz. This report consists of two parts: In the first one it is described how have been satisfied each one of the compromises. The second one talks about the Laws and Regulations on nuclear activities in the country. (Author)

  6. Compromise and Toleration

    DEFF Research Database (Denmark)

    Rostbøll, Christian F.

    Political compromise is akin to toleration, since both consist of an "agreement to disagree." Compromise and toleration also share a predicament of being regarded as ambiguous virtues that require of us to accept something we actually regard as wrong. However, we misunderstand the nature, justifi...... in compromise are more stringent than those for being tolerated. Still, the limits of compromise cannot be drawn to narrowly if it is to remain its value as a form of agreement that respects and embodies the differences of opinion in society.......Political compromise is akin to toleration, since both consist of an "agreement to disagree." Compromise and toleration also share a predicament of being regarded as ambiguous virtues that require of us to accept something we actually regard as wrong. However, we misunderstand the nature......, justification, and limits of compromise if we see it merely as a matter of toleration. While toleration is mainly a matter of accepting citizens' equal right to co-existence as subjects to law, political compromise includes the parties in making law – it makes them co-authors of law. Toleration entails...

  7. Democratic Respect and Compromise

    DEFF Research Database (Denmark)

    Rostbøll, Christian F.

    2017-01-01

    Compromise has attained renewed interest among political theorists writing on pluralism and disagreement. It is controversial, however, whether compromise is a mere pragmatic necessity or if it has non-instrumental value. This article argues that the reasons for compromise are inherent in the dem......Compromise has attained renewed interest among political theorists writing on pluralism and disagreement. It is controversial, however, whether compromise is a mere pragmatic necessity or if it has non-instrumental value. This article argues that the reasons for compromise are inherent...

  8. Impending Airway Compromise due to Cystic Hygroma

    Directory of Open Access Journals (Sweden)

    Itai Shavit

    2011-05-01

    Full Text Available We report on a 3-month-old infant, who arrived in the pediatric emergency department (ED with a cervical cystic hygroma causing an impending compromise of the airway. We recognize that such a lesion can rapidly progress, and the judicious use of imaging in the ED may help to avoid airway compromise and possibly fatal complications. [West J Emerg Med. 2011;12(4:368–369.

  9. Kyphoplasty for osteoporotic fractures with spinal canal compromise

    International Nuclear Information System (INIS)

    Gan Minfeng; Yang Huilin; Zou Jun; Wang Genlin; Mei Xin; Zhou Feng; Chen Liang; Jiang Weimin

    2010-01-01

    Objective: To explore the feasibility and clinical outcome of kyphoplasty in the treatment of osteoporotic fractures with canal compromise. Methods: A total of 16 patients with osteoporotic fractures with canal compromise without neurological deficit were attempted to be treated by kyphoplasty. During kyphoplasty, modified techniques including staged bone cement injection and dynamic fluoroscopic monitoring were used. Pain was measured using the self-reporting Visual Analogue pain Scale (VAS) preoperatively, postoperatively and in the final follow-up. Disability was measured using the Oswestry Disability questionnaire (ODI) preoperatively, postoperatively and in the final follow-up. The height of the compromised vertebral body, the kyphotic angle and the spinal canal compromise were measured preoperatively, postoperatively and in the final follow-up. Results: Operations were completed smoothly, with the exception of one patient with less cement leakage but without clinical symptom occurred. Relief of pain was achieved after kyphoplasty. The mean VAS score of these patients decreased from 8.1 ± 1.2 pre-operatively to 2.7 ± 0.6 post-operatively (P 0.05). In the final follow-up, the spinal canal compromise was (14.4 ± 3.1)%. Conclusion: Kyphoplasty is a relatively safe and effective method for the treatment of osteoporotic fractures with canal compromise without neurological deficit. (authors)

  10. The compromised gut in the neonate : Diagnostic and clinical aspects

    NARCIS (Netherlands)

    Schurink, Maarten

    2016-01-01

    Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease predominantly occurring in preterm infants, causing significant patient morbidity and mortality. It is characterized by loss of bowel wall integrity due to ischemia (lack of oxygen due to a compromised blood flow) and

  11. Compromises.

    Science.gov (United States)

    Sizer, Theodore R.

    1984-01-01

    Taking as examples the issues of improving students'"high order thinking skills" and arriving at more equitable teacher salaries and school budgets, the author discusses the need for compromise solutions to widespread problems. (JBM)

  12. Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma

    Science.gov (United States)

    Chaturvedi, Aashi; Hoffman, Laura M.; Jensen, Christopher C.; Lin, Yi-Chun; Grossmann, Allie H.; Randall, R. Lor; Lessnick, Stephen L.; Welm, Alana L.; Beckerle, Mary C.

    2014-01-01

    Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon presentation. Silencing of EWS/FLI in patient-derived tumor cells results in the altered expression of hundreds to thousands of genes and is accompanied by dramatic morphological changes in cytoarchitecture and adhesion. Genes encoding focal adhesion, extracellular matrix, and actin regulatory proteins are dominant targets of EWS/FLI-mediated transcriptional repression. Reexpression of genes encoding just two of these proteins, zyxin and α5 integrin, is sufficient to restore cell adhesion and actin cytoskeletal integrity comparable to what is observed when the EWS/FLI oncogene expression is compromised. Using an orthotopic xenograft model, we show that EWS/FLI-induced repression of α5 integrin and zyxin expression promotes tumor progression by supporting anchorage-independent cell growth. This selective advantage is paired with a tradeoff in which metastatic lung colonization is compromised. PMID:25057021

  13. Determining the maximum diameter for holes in the shoe without compromising shoe integrity when using a multi-segment foot model.

    Science.gov (United States)

    Shultz, Rebecca; Jenkyn, Thomas

    2012-01-01

    Measuring individual foot joint motions requires a multi-segment foot model, even when the subject is wearing a shoe. Each foot segment must be tracked with at least three skin-mounted markers, but for these markers to be visible to an optical motion capture system holes or 'windows' must be cut into the structure of the shoe. The holes must be sufficiently large avoiding interfering with the markers, but small enough that they do not compromise the shoe's structural integrity. The objective of this study was to determine the maximum size of hole that could be cut into a running shoe upper without significantly compromising its structural integrity or changing the kinematics of the foot within the shoe. Three shoe designs were tested: (1) neutral cushioning, (2) motion control and (3) stability shoes. Holes were cut progressively larger, with four sizes tested in all. Foot joint motions were measured: (1) hindfoot with respect to midfoot in the frontal plane, (2) forefoot twist with respect to midfoot in the frontal plane, (3) the height-to-length ratio of the medial longitudinal arch and (4) the hallux angle with respect to first metatarsal in the sagittal plane. A single subject performed level walking at her preferred pace in each of the three shoes with ten repetitions for each hole size. The largest hole that did not disrupt shoe integrity was an oval of 1.7cm×2.5cm. The smallest shoe deformations were seen with the motion control shoe. The least change in foot joint motion was forefoot twist in both the neutral shoe and stability shoe for any size hole. This study demonstrates that for a hole smaller than this size, optical motion capture with a cluster-based multi-segment foot model is feasible for measure foot in shoe kinematics in vivo. Copyright © 2011. Published by Elsevier Ltd.

  14. Organizational aspects of integrated reporting preparation according to international standard «Integrated reporting»

    Directory of Open Access Journals (Sweden)

    M.O. Maksymchuk

    2016-12-01

    Full Text Available Integrated Reporting is an innovative reporting for business entities, therefore the issue of the organization the preparation of this reporting is an actual. The absence of legislative regulation of integrated reporting at national level of legal documents has greatly affected the issue, because the only document, that specifies the requirements for integrated reporting is the international standard «integrated reporting». The article considers the organizational principles of integrated reporting preparation. Taking into account the requirements of the international standard «integrated reporting», the authors make the attempts to define the basic organizational stages of such reporting, that allows to introduce the integrated reporting in a structured way and logically. It is proposed on the enterprises preparing the integrated reporting to constitute the schedule of the formation of the integrated reporting. In addition, the important thing is to develop the internal policy for determining materiality by the use of the professional judgment. The appropriate internal policy is assigned to disclose the materiality process in an integrated reporting for decision-making on the inclusion or exclusion issues to be understandable for users.

  15. Compromise and Disagreement in Comtemporary Political Theory

    DEFF Research Database (Denmark)

    Rostbøll, Christian F.; Scavenius, Theresa

    Compromise and Disagreement in Contemporary Political Theory provides a critical discussion of when and to what extent compromise is the best response to pluralism and disagreement in democratic decision-making and beyond. Organized into four parts, the book begins by discussing the justification...... and limits of compromise. Part II discusses the practice of compromise and considers the ethics required for compromise as well as the institutions that facilitate compromise. Part III focuses on pluralism and connects the topic of compromise to current discussions in political theory on public reason...

  16. Integrated reporting and board features

    Directory of Open Access Journals (Sweden)

    Rares HURGHIS

    2017-02-01

    Full Text Available In the last two decades the concept of sustainability reporting gained more importance in the companies’ annual reports, a trend which is embedded also in integrated reporting. Issuing an integrated report became a necessity, because the report explains to the investors how the organization creates value over time. The governance structure, more exactly the board of directors, decides whether or not the company will issue an integrated report. Thus, are there certain features of the board that might influence the issue of an integrated report? Do the companies which issue an integrated report have certain features of the governance structure? Looking for an answer to these questions, we seek for any possible correlations between a disclosure index and the corporate governance structure characteristics, on a sample from the companies participating at the International Integrated Reporting Council Examples Database. The results highlight that only the size of the board influences the extent to which the issued integrated report is in accordance with the International Framework.

  17. 36 CFR 1011.7 - When will the Presidio Trust compromise a debt?

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false When will the Presidio Trust... Procedures To Collect Presidio Trust Debts § 1011.7 When will the Presidio Trust compromise a debt? (a... debt owed to the Presidio Trust that is not recovered as the result of a compromise will be reported to...

  18. How moral disagreement may ground principled moral compromise

    DEFF Research Database (Denmark)

    Kappel, Klemens

    2018-01-01

    In an influential article, Simon C. May forcefully argued that, properly understood, there can never be principled reasons for moral compromise (May, 2005). While there may be pragmatic reasons for compromising that involve, for instance, concern for political expediency or for stability, there a......In an influential article, Simon C. May forcefully argued that, properly understood, there can never be principled reasons for moral compromise (May, 2005). While there may be pragmatic reasons for compromising that involve, for instance, concern for political expediency or for stability......, there are properly speaking no principled reasons to compromise. My aim in the article is to show how principled moral compromise in the context of moral disagreements over policy options is possible. I argue that when we disagree, principled reasons favoring compromises or compromising can assume a more significant...... part of what makes a position all things considered best, and in this way disagreement can ground moral compromise....

  19. Wind Integration into Energy Systems with a High Share of Nuclear Power—What Are the Compromises?

    Directory of Open Access Journals (Sweden)

    Behnam Zakeri

    2015-03-01

    Full Text Available Towards low-carbon energy systems, there are countries with ongoing plans for expanding their nuclear power capacity, and simultaneously advancing the role of variable renewable energy sources (RES, namely wind and solar energy. This crossroads of capital-intensive, baseload power production and uncontrollable, intermittent RES may entail new challenges in the optimal and economic operation of power systems. This study examines this case by hourly analysis of a national-level energy system with the EnergyPLAN modeling tool, coupled with wind integration simulations (including uncertainty implemented using MATLAB. We evaluate the maximum feasible wind integration under different scenarios for nuclear power plants, energy demand, and the flexibility of energy infrastructure for a real case study (Finland. We propose wind-nuclear compromise charts to envision the impact of any mix of these two technologies on four parameters: total costs, power exchange, carbon emissions, and renewable energy integration. The results suggest that nuclear power constrains the room for maximum uptake of wind energy by a descending parabolic relationship. If nuclear power production exceeds 50% of the total power demand, wind will be unlikely to penetrate in shares over 15% of the respective demand. Moreover, we investigate the role of four flexibility options: demand side management, electrical energy storage, smart electric heating, and large-scale heat pumps (backed with thermal energy storage. Heat pumps (which are in connection with combined heat and power (CHP and district heating systems offer the highest efficiency in balancing excess power from variable RES. However, power-to-heat options offer a limited capability for absorbing excess power, as oversupply arises mainly in the periods with relatively low demand for heat. This calls for longer-term energy storage and/or other flexibility options to achieve the planned targets in wind-nuclear scenarios.

  20. Does low self-esteem predict health compromising behaviours among adolescents?

    Science.gov (United States)

    Mcgee, R; Williams, S

    2000-10-01

    It is often believed that low self-esteem is associated with such health-compromising behaviours in adolescence as substance use, early sexual activity, eating problems and suicidal ideation. Surprisingly, there is little longitudinal research addressing this issue. This longitudinal study examines the predictive association between both global and academic self-esteem from ages 9 to 13 years, and a variety of health compromising behaviours at age 15, in a large sample of young New Zealanders. Levels of global self-esteem significantly predicted adolescent report of problem eating, suicidal ideation, and multiple health compromising behaviours. Earlier levels of self-esteem were unrelated to later substance use and early sexual activity. The findings are discussed in terms of their implications for efforts to raise self-esteem among young people. Copyright 2000 The Association for Professionals in Services for Adolescents.

  1. Investigation of Integrated Reporting As a New Approach of Corporate Reporting

    Directory of Open Access Journals (Sweden)

    Ibrahim Erol

    2016-11-01

    Full Text Available When the recent history of financial, social, environmental and ethical reporting is examined, the idea that increasing expectations of shareholders and stakeholders on transparency and accountability can be met by a single report has great importance. Therefore, the integrated reporting issue after the sustainability reports is on the agenda. When we look at the development of integrated reporting and Corporate Reporting (CR, since integrated reporting has complicated theoretical background, organizations have difficulties to understand whether their report is an integrated one. So in this study we try to reveal basic principles, theoretical background and development process of integrated reporting. We look at globally the development of integrated reporting between the years 1999-2015 on Global Reporting Initiative (GRI database and prepared visual tables showing the development of Integrated Reporting (IR aiming to create positive contribute to CR literature.  In the present study; we determine that in 2012 integrated reporting is made the most, large businesses prefer integrated reporting the most, integrated reporting is made in European region the most, and financial services sector is the sector publishing integrated report the most.

  2. Energy policy - compromise or change?

    International Nuclear Information System (INIS)

    Lewitz, J.C.

    1998-01-01

    Is there a contrast between compromise and change? In the author's opinion, there is not. Society changes. Sometimes, change is brought about more easily on the basis of a compromise. A pluralistic society needs compromises in order to participate in change with convictions of its own. To reach a compromise including a large part of one's conviction, the public must be convinced. This is achieved most easily by somebody who is well informed, educated, and trained. In this respect, not only specialized knowledge counts, but also the ability to handle the language and to know how to speak, and the behavior in public. Expert knowledge is acquired at the university, in the execution of one's profession, and in advanced training. Knowledge may be enhanced, for instance, by dealing with the arguments used by the other side. This will help in arguing one's own point more effectively. Individual talks, and events at which information and knowledge are disseminated, enable persons to assume an opinion based on their comprehension. Many uniform opinions create a majority opinion. (orig.) [de

  3. 6 CFR 13.46 - Compromise or settlement.

    Science.gov (United States)

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Compromise or settlement. 13.46 Section 13.46 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.46 Compromise or settlement. (a) Parties may Make offers of compromise or settlement at any time...

  4. NEW CORPORATE REPORTING TRENDS. ANALYSIS ON THE EVOLUTION OF INTEGRATED REPORTING

    Directory of Open Access Journals (Sweden)

    Dragu Ioana

    2013-07-01

    Full Text Available The objective of this paper is to present the new corporate reporting trends of the 21st century. Integrated reporting has been launched through a common initiative of the International Integrated Reporting Committee and global accounting organizations. However, the history of integrated reports starts before the initiative of the IIRC, and goes back in time when large corporations begun to disclose sustainability and corporate social responsibility information. Further on, we claim that the initial sustainability and CSR reports that were issued separate along with the financial annual report represent the predecessors of the current integrated reports. The paper consists of a literature review analysis on the evolution of integrated reporting, from the first stage of international non-financial initiatives, up to the current state of a single integrated annual report. In order to understand the background of integrated reporting we analyze the most relevant research papers on corporate reporting, focusing on the international organizations’ perspective on non-financial reporting, in general, and integrated reporting, in particular. Based on the literature overview, we subtracted the essential information for setting the framework of the integrated reporting evolution. The findings suggest that we can delimitate three main stages in the evolution of integrated reports, namely: the non-financial reporting initiatives, the sustainability era, and the revolution of integrated reporting. We illustrate these results by presenting each relevant point in the history of integrated reporting on a time scale axis, developed with the purpose of defining the road to integrated reporting at theoretical, empirical, and practical levels. We consider the current investigation as relevant for future studies concerning integrated reports, as this is a new area of research still in its infancy. The originality of the research derives from the novelty of

  5. Cyber indicators of compromise: a domain ontology for security information and event management

    Science.gov (United States)

    2017-03-01

    heuristics, mapping, and detection. CybOX is aimed at supporting a broad range of important cyber security domains to include [31]: • Digital...REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE CYBER INDICATORS OF COMPROMISE: A DOMAIN ONTOLOGY FOR SECURITY INFORMATION AND...Distribution is unlimited. CYBER INDICATORS OF COMPROMISE: A DOMAIN ONTOLOGY FOR SECURITY INFORMATION AND EVENT MANAGEMENT Marsha D. Rowell

  6. Surgical extrusion: A reliable technique for saving compromised teeth. A 5-years follow-up case report

    Directory of Open Access Journals (Sweden)

    Jenner Argueta

    2018-06-01

    Full Text Available Aim: To present a long term follow up clinical case in which a compromised anterior tooth was saved by a surgical extrusion procedure. Summary: Although different techniques have been suggested for clinical crown lengthening in the anterior zone, some of them have limitations in terms of aesthetics and procedural requirements. The current case report demonstrates how a simplified surgical extrusion procedure was successfully performed for saving a severely damaged anterior tooth; furthermore, it is possible to apply the technique described in this case using minimum and simple armamentarium like a scalpel, elevators, forceps and splinting flexible cord. Key-learning points: Saving severely compromised anterior teeth is possible by applying surgical extrusion techniques when crown-root ratio allows it. Risk of root resorption or ankylosis is minimum. Riassunto: Obiettivo: Presentare un caso clinico con controllo a 5 anni in cui un dente anteriore compromesso è stato recuperato con una procedura di estrusione chirurgica. Riassunto: Sebbene siano state suggerite diverse tecniche per l’allungamento della corona clinica nella zona anteriore, alcune di esse presentano limitazioni in termini di estetica e competenza nelle procedure. Il presente case report dimostra come una procedura di estrusione chirurgica semplificata sia stata eseguita con successo per salvare un dente anteriore gravemente danneggiato. Va sottolineato che la tecnica descritta in questo caso può essere portata a termine utilizzando un armamentario minimo e molto semplice come un bisturi, leve, pinze e uno splintaggio flessibile. Key learning points: E’ possibile salvare elementi dentari gravemente compromessi applicando tecniche di estrusione chirurgica quando il rapporto corona-radice lo consente. Il rischio di riassorbimento della radice o anchilosi è minimo. Keywords: Crown fracture, Crown lengthening, Surgical extrusion, Surgical repositioning, Biologic width, Parole

  7. Career Compromises: Framings and Their Implications.

    Science.gov (United States)

    Gati, Itamar; Houminer, Daphna; Aviram, Tamar

    1998-01-01

    Career compromise was investigated in three framings (alternatives, aspect importance, within-aspect preference). Young adults and school counselors rated hypothetical stories. Results of four studies with different designs (Average N=106) supported the hypothesis. The alternatives framing was associated with greater compromise and decision…

  8. Taking Responsibility: The integration of Sustainability and Project Management

    NARCIS (Netherlands)

    Jasper van den Brink; Gilbert Gilbert Silvius

    2011-01-01

    Sustainability is one of the most important challenges of our time. How can we develop prosperity, without compromising the life of future generations? Companies are integrating ideas of sustainability in their marketing, corporate communications, annual reports and in their actions. Projects as

  9. Neutrophils Compromise Retinal Pigment Epithelial Barrier Integrity

    Directory of Open Access Journals (Sweden)

    Jiehao Zhou

    2010-01-01

    Full Text Available We hypothesized that neutrophils and their secreted factors mediate breakdown of the integrity of the outer blood-retina-barrier by degrading the apical tight junctions of the retinal pigment epithelium (RPE. The effect of activated neutrophils or neutrophil cell lysate on apparent permeability of bovine RPE-Choroid explants was evaluated by measuring [H] mannitol flux in a modified Ussing chamber. The expression of matrix metalloproteinase- (MMP- 9 in murine peritoneal neutrophils, and the effects of neutrophils on RPE tight-junction protein expression were assessed by confocal microscopy and western blot. Our results revealed that basolateral incubation of explants with neutrophils decreased occludin and ZO-1 expression at 1 and 3 hours and increased the permeability of bovine RPE-Choroid explants by >3-fold (P<.05. Similarly, basolateral incubation of explants with neutrophil lysate decreased ZO-1 expression at 1 and 3 hours (P<.05 and increased permeability of explants by 75%. Further, we found that neutrophils prominently express MMP-9 and that incubation of explants with neutrophils in the presence of anti-MMP-9 antibody inhibited the increase in permeability. These data suggest that neutrophil-derived MMP-9 may play an important role in disrupting the integrity of the outer blood-retina barrier.

  10. A new dimension of the entities’ financial reporting: Integrated Reporting

    Directory of Open Access Journals (Sweden)

    LAPTES Ramona

    2017-01-01

    Full Text Available Nowadays, the development strategy of big corporations is based on the principle of sustainable development, which includes both protecting the interests of all involved economic actors and minimizing the aggression on natural resources. In this context, the financial communication process in large companies has acquired new meanings, being reconsidered and taking the form of Integrated Reporting. The objective of this paper is to develop a study regarding the theory of Integrated Reporting, based on a documentary research on the reports published by the International Integrated Reporting Council and organizations such as KPMG, E&Y or ACCA. Integrated Reporting is a new practice, still under development and in expansion at international level. An integrated report tells the story of a company’s journey towards achieving its vision and provides information about its historical performance, but also about the expected one.

  11. Dental management of medically compromised patients

    Directory of Open Access Journals (Sweden)

    Sherly Horax

    2016-06-01

    Full Text Available These days, treatment in dentistry is no longer for patient without complication, but also for patient with bad medical record. With correct treatment management in handling medical condition of patient, not only for dental treatment but also their systematic disease, all the dental staff also can improve for the better quality of life of the patient. Patient with medical compromised start to realize that  keeping good oral hygiene is so important for their lives, therefore dental staff need to improve their science and technology and also for facing patient with medical compromised. This article will discuss and suggest various treatment consideration and protocol for the patient of with medical compromised.

  12. Leading practices in Integrated Reporting

    OpenAIRE

    Quattrone, Paolo; Busco, Cristiano; Frigo, Mark L; Riccaboni, Angelo

    2014-01-01

    Integrated Reporting (IR) is making the leap from promising concept to powerfulpractice. Released at the end of 2013 by the International IntegratedReporting Council (IIRC), a global coalition of regulators, investors, companies,standards setters, the accounting profession, and nongovernmental organizations(NGOs), the IR Framework has been robustly tested and piloted in25 countries. As we described in the article “Redefining Corporate Accountabilitythrough Integrated Reporting” (Strategic Fin...

  13. Data report for the integrity assessment report HNF-4589

    International Nuclear Information System (INIS)

    MCSHANE, D.S.

    1999-01-01

    Supporting data for the Integrity Assessment Report of Tanks TK-101 and TK-102. The purpose of this document is to compile supporting documentation for the Integrity Assessment Report (HNF 4589) for Tanks 101 and 102 in the 2194 Facility. This approach minimizes the size of the Integrity Assessment Report (IAR) (HNF-4589) and still provide a path to detailed information. This IAR addresses the evaluation of Tanks 101 and 102 and other existing components located in the 219-5 Waste Handling Facility

  14. Compromise in cooperative game and the VIKOR method

    Directory of Open Access Journals (Sweden)

    Opricović Serafim

    2009-01-01

    Full Text Available Five approaches in conflict resolution are distinguished, based on cooperativeness and aggressiveness in resolving conflict. Compromise based on cooperativeness is emphasized here as a solution in conflict resolution. Cooperative game theory oriented towards aiding the conflict resolution is considered and the compromise value for TU(transferable utility-game is presented. The method VIKOR could be applied to determine compromise solution of a multicriteria decision making problem with noncommensurable and conflicting criteria. Compromise is considered as an intermediate state between conflicting objectives or criteria reached by mutual concession. The applicability of the cooperative game theory and the VIKOR method for conflict resolution is illustrated.

  15. Practical use of the integrated reporting framework – an analysis of the content of integrated reports of selected companies

    Directory of Open Access Journals (Sweden)

    Monika Raulinajtys-Grzybek

    2017-09-01

    Full Text Available Practical use of the integrated reporting framework – an analysis of the content of integrated reports of selected companies The purpose of the article is to provide a research tool for an initial assessment of whether a company’s integrated reports meet the objectives set out in the IIRC Integrated Reporting Framework and its empirical verification. In particular, the research addresses whether the reports meet the goal of improving the quality of information available and covering all factors that influence the organization’s ability to create value. The article uses the theoretical output on the principles of preparing integrated reports and analyzes the content of selected integrated reports. Based on the source analysis, a research tool has been developed for an initial assessment of whether an integrated report fulfills its objectives. It consists of 42 questions that verify the coverage of the defined elements and the implementation of the guiding principles set by the IIRC. For empirical verification of the tool, a comparative analysis was carried out for reports prepared by selected companies operating in the utilities sector. Answering questions from the research tool allows a researcher to formulate conclusions about the implementation of the guiding principles and the completeness of the presentation of the content elements. As a result of the analysis of selected integrated reports, it was stated that various elements of the report are presented with different levels of accuracy in different reports. Reports provide the most complete information on performance and strategy. The information about business model and prospective data is in some cases presented without making a link to other parts of the report – e.g. risks and opportunities, financial data or capitals. The absence of such links limits the ability to claim that an integrated report meets its objectives, since a set of individual reports, each presenting

  16. Ortho-perio integrated approach in periodontally compromised patients

    Science.gov (United States)

    Ramachandra, C. S.; Shetty, Pradeep Chandra; Rege, Sanyukta; Shah, Chitrang

    2011-01-01

    It is an undisputed fact that sound and strong periodontal health is a must in patients seeking orthodontic treatment. Does this mean that we are going to deny orthodontic treatment for those adults whose number is rising, more often secondary to periodontal deterioration and pathological migration of teeth resulting in aesthetic and functional problems? Need of the hour is to have an integrated approach where in periodontal treatment precedes orthodontic treatment to restore periodontal health. Orthodontic treatment should be performed under strict plaque control measures to place the teeth in a structurally balanced and functionally efficient position. Aim of this article is to familiarize the practicing clinicians both in the field of orthodontics and periodontics with current thoughts and successful clinical techniques used in the field of periodontology to regenerate lost periodontal structures. Furthermore, it aims to integrate such techniques into the orthodontic treatment of patients with severe bone loss. PMID:22368371

  17. 22 CFR 213.25 - Standards for compromise.

    Science.gov (United States)

    2010-04-01

    ... proceedings. In evaluating the acceptability of the offer, the CFO may consider, among other factors, the... applicable exemptions available to the debtor under State and Federal law in determining the Government's ability to enforce collection. (b) USAID may compromise a claim, or recommend acceptance of a compromise...

  18. 20 CFR 255.18 - Compromise of overpayments.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Compromise of overpayments. 255.18 Section 255.18 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT... standards which the Board applies in exercising its authority under 31 U.S.C. 3711 to compromise an...

  19. 16 CFR 1.96 - Compromise of penalty.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Compromise of penalty. 1.96 Section 1.96 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE GENERAL... may compromise any penalty or proposed penalty at any time, with leave of court when necessary, taking...

  20. The effect of integrated reporting on integrated thinking between risk ...

    African Journals Online (AJOL)

    ... between strategy and the risks and opportunities faced by the organisation. For this purpose, a web-based research questionnaire was sent to high-level implementers of integrated reporting at companies listed on the Johannesburg Stock Exchange (JSE) in South Africa, where integrated reporting is a listing requirement.

  1. Firm characteristics and excellence in integrated reporting

    Directory of Open Access Journals (Sweden)

    Natasha Buitendag

    2017-02-01

    Full Text Available Background: Integrated reporting has attracted much attention in the past few years, and South Africa has taken the lead in its development worldwide. An annual survey is published by Ernst & Young regarding the quality of the integrated reports of the top 100 entities listed on the Johannesburg Stock Exchange (JSE. Aim: The study on which this article is based was aimed at determining whether the assessment of an entity’s characteristics can predetermine the quality of the integrated report generated by that entity. Setting: This article focuses on an analysis of the integrated reporting of the top 100 entities listed on JSE for the financial years ending in 2013, 2014 and 2015. Methods: Comparison of categorical variables, mixed-model repeated measures ANOVA and generalised estimating equations were applied to identify the best classificators to distinguish between excellent integrated reporting and those reports where progress could still be made. Results: The results show that the type of industry the entity finds itself in, the size and profitability of the entity, as well as the composition of the members of the board, have an effect on the quality of the integrated report. Conclusion: Our results indicated that the type of industry, size of an entity, the profitability and composition of the board of directors, all have an effect on the quality of the integrated reporting. Our evidence will assist current and prospective stakeholders in evaluating the expected quality of an entity’s integrated report, through the evaluation of certain firm characteristics.

  2. NEW CORPORATE REPORTING TRENDS. ANALYSIS ON THE EVOLUTION OF INTEGRATED REPORTING

    OpenAIRE

    Dragu Ioana; Tiron-Tudor Adriana

    2013-01-01

    The objective of this paper is to present the new corporate reporting trends of the 21st century. Integrated reporting has been launched through a common initiative of the International Integrated Reporting Committee and global accounting organizations. However, the history of integrated reports starts before the initiative of the IIRC, and goes back in time when large corporations begun to disclose sustainability and corporate social responsibility information. Further on, we claim that the ...

  3. Strained Compromises?

    DEFF Research Database (Denmark)

    Ibsen, Christian Lyhne

    The Danish version of flexicurity is not only about a balance between labour market flexibility and social security. Arguably, it is also series of more or less stable underlying compromises between social partners about the main mechanisms and aims of labour market regulation which – supposedly...... – should be focused on employment rather than jobs and competition on quality rather than on labour costs. However, most studies on Danish flexicurity have been carried out under favourable economic conditions with social partners almost naturally agreeing to the merits of the model – at least in principle...

  4. Compromised data from social media to big data

    CERN Document Server

    Redden, Joanna; Langlois, Ganaele

    2015-01-01

    There has been a data rush in the past decade brought about by online communication and, in particular, social media (Facebook, Twitter, Youtube, among others), which promises a new age of digital enlightenment. But social data is compromised: it is being seized by specific economic interests, it leads to a fundamental shift in the relationship between research and the public good, and it fosters new forms of control and surveillance. Compromised Data: From Social Media to Big Data explores how we perform critical research within a compromised social data framework. The expert, international l

  5. Flow-based Compromise Detection

    NARCIS (Netherlands)

    Hofstede, R.J.

    2016-01-01

    Brute-force attacks are omnipresent and manyfold on the Internet, and aim at compromising user accounts by issuing large numbers of authentication attempts on applications and daemons. Widespread targets of such attacks are Secure SHell (SSH) and Web applications, for example. The impact of

  6. Managing the Technology Acquisition Integration Paradox at SAP

    DEFF Research Database (Denmark)

    Henningsson, Stefan; Kude, Thomas; Popp, Karl Michael

    2016-01-01

    rests in ensuring critical speed while not compromising accuracy in the integration process. For SAP, the Product Council became a vital component in its technology acquisition capability that allows the company to retain its technological edge in the hypercompetitive software industry.......In this paper, we report on a novel approach developed by SAP AG, the German enterprise software company, for managing the integration of acquisitions of companies to access innovative technologies and related capabilities: the Product Council approach. The value of the Product Council approach...

  7. Integrated Budget Office Toolbox

    Science.gov (United States)

    Rushing, Douglas A.; Blakeley, Chris; Chapman, Gerry; Robertson, Bill; Horton, Allison; Besser, Thomas; McCarthy, Debbie

    2010-01-01

    The Integrated Budget Office Toolbox (IBOT) combines budgeting, resource allocation, organizational funding, and reporting features in an automated, integrated tool that provides data from a single source for Johnson Space Center (JSC) personnel. Using a common interface, concurrent users can utilize the data without compromising its integrity. IBOT tracks planning changes and updates throughout the year using both phasing and POP-related (program-operating-plan-related) budget information for the current year, and up to six years out. Separating lump-sum funds received from HQ (Headquarters) into separate labor, travel, procurement, Center G&A (general & administrative), and servicepool categories, IBOT creates a script that significantly reduces manual input time. IBOT also manages the movement of travel and procurement funds down to the organizational level and, using its integrated funds management feature, helps better track funding at lower levels. Third-party software is used to create integrated reports in IBOT that can be generated for plans, actuals, funds received, and other combinations of data that are currently maintained in the centralized format. Based on Microsoft SQL, IBOT incorporates generic budget processes, is transportable, and is economical to deploy and support.

  8. The emergence of integrated private reporting

    OpenAIRE

    Atkins, Jill; Solomon, A.; Norton, S. D.; Joseph, N. L.

    2015-01-01

    Purpose: Private social and environmental reporting (SER) has grown considerably in recent years, consistent with a rise in institutional investor engagement and dialogue with investee companies. We interpret the emergence of integrated private reporting through the lens of institutional logics. We frame the emergence of integrated private reporting as a merging of two hitherto separate and possibly rival institutional logics.\\ud Methodology/Approach: We interviewed 19 companies listed on the...

  9. Data report for the integrity assessment report HNF-4589

    Energy Technology Data Exchange (ETDEWEB)

    MCSHANE, D.S.

    1999-10-27

    The purpose of this document is to compile supporting documentation for the Integrity Assessment Report (HNF 4589) for Tanks 101 and 102 in the 2194 Facility. This approach minimizes the size of the Integrity Assessment Report (IAR) (HNF-4589) and still provide a path to detailed information. This IAR addresses the evaluation of Tanks 101 and 102 and other existing components located in the 219-5 Waste Handling Facility.

  10. 32 CFR 310.14 - Notification when information is lost, stolen, or compromised.

    Science.gov (United States)

    2010-07-01

    ... THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Systems of Records § 310.14... the individual of any loss, theft, or compromise (See also, § 310.50 for reporting of the breach to Senior Component Official for Privacy and the Defense Privacy Office). (1) The notification shall be made...

  11. 41 CFR 105-55.019 - Compromise of claims.

    Science.gov (United States)

    2010-07-01

    ... and a recommendation for the acceptance of the compromise offer. Justice Department approval is not... exercise the authorities in this section. (b) Unless otherwise provided by law, when the principal balance... Department of Justice. GSA will evaluate the compromise offer, using the factors set forth in § 105-55.020...

  12. The role of postoperative hematoma on free flap compromise.

    Science.gov (United States)

    Ahmad, Faisal I; Gerecci, Deniz; Gonzalez, Javier D; Peck, Jessica J; Wax, Mark K

    2015-08-01

    Hematomas may develop in the postoperative setting after free tissue transfer. When hematomas occur, they can exert pressure on surrounding tissues. Their effect on the vascular pedicle of a free flap is unknown. We describe our incidence of hematoma in free flaps and outcomes when the flap is compromised. Retrospective chart review of 1,883 free flaps performed between July 1998 and June 2014 at a tertiary referral center. Patients with free flap compromise due to hematoma were identified. Etiology, demographic data, and outcomes were evaluated. Eighty-eight (4.7%) patients developed hematomas. Twenty (22.7%) of those had flap compromise. Twelve compromises (60%) showed evidence of pedicle thrombosis. The salvage rate was 75% versus 54% in 79 flaps with compromise from other causes (P = .12). Mean time to detection of the hematoma was 35.3 hours in salvaged flaps compared to 91.6 hours in unsalvageable flaps (P = .057). Time to operating room (OR) from detection was 2.8 hours in salvageable flaps compared to 12.4 hours in nonsalvageable flaps (P = .053). The salvage rate for flaps that returned to the OR in hematomas developed rarely. When they did, 23% went on to develop flap compromise. Prompt recognition and re-exploration allowed for a high salvage rate. Vessel thrombosis predicted inability to salvage the flap. 4 © 2015 The American Laryngological, Rhinological and Otological Society, Inc.

  13. Integrated Reporting Information System -

    Data.gov (United States)

    Department of Transportation — The Integrated Reporting Information System (IRIS) is a flexible and scalable web-based system that supports post operational analysis and evaluation of the National...

  14. Orthodontic space closure using simple mechanics in compromised first molar extraction spaces: Case series

    Directory of Open Access Journals (Sweden)

    Prashant M Dhole

    2018-01-01

    Full Text Available Orthodontic treatments involving missing or compromised first permanent molars are often challenging cases to treat considering the loss of potential anchor tooth. The case series presents orthodontic treatment in three patients with mutilated/absent first permanent molars. The treatment goals were to be accomplished by extraction of compromised teeth and retention of healthy dentition. The diagnosis and problem list needed extractions to accomplish the treatment goals. The possibility of extracting compromised first permanent molars instead of other healthy teeth was considered. A setup was done to determine the final occlusion in asymmetric extraction cases. Fixed appliances were used with simple mechanics without any additional anchorage devices. Case-based retention protocols were followed. All the three patients achieved the predetermined treatment objectives of improved esthetics and healthy and stable functional occlusion. The simple and efficient mechanics and finishing techniques for comprehensive orthodontic treatment with first molar extractions presented in the report should help clinicians when treating similar patients.

  15. Combating QR-Code-Based Compromised Accounts in Mobile Social Networks.

    Science.gov (United States)

    Guo, Dong; Cao, Jian; Wang, Xiaoqi; Fu, Qiang; Li, Qiang

    2016-09-20

    Cyber Physical Social Sensing makes mobile social networks (MSNs) popular with users. However, such attacks are rampant as malicious URLs are spread covertly through quick response (QR) codes to control compromised accounts in MSNs to propagate malicious messages. Currently, there are generally two types of methods to identify compromised accounts in MSNs: one type is to analyze the potential threats on wireless access points and the potential threats on handheld devices' operation systems so as to stop compromised accounts from spreading malicious messages; the other type is to apply the method of detecting compromised accounts in online social networks to MSNs. The above types of methods above focus neither on the problems of MSNs themselves nor on the interaction of sensors' messages, which leads to the restrictiveness of platforms and the simplification of methods. In order to stop the spreading of compromised accounts in MSNs effectively, the attacks have to be traced to their sources first. Through sensors, users exchange information in MSNs and acquire information by scanning QR codes. Therefore, analyzing the traces of sensor-related information helps to identify the compromised accounts in MSNs. This paper analyzes the diversity of information sending modes of compromised accounts and normal accounts, analyzes the regularity of GPS (Global Positioning System)-based location information, and introduces the concepts of entropy and conditional entropy so as to construct an entropy-based model based on machine learning strategies. To achieve the goal, about 500,000 accounts of Sina Weibo and about 100 million corresponding messages are collected. Through the validation, the accuracy rate of the model is proved to be as high as 87.6%, and the false positive rate is only 3.7%. Meanwhile, the comparative experiments of the feature sets prove that sensor-based location information can be applied to detect the compromised accounts in MSNs.

  16. Combating QR-Code-Based Compromised Accounts in Mobile Social Networks

    Directory of Open Access Journals (Sweden)

    Dong Guo

    2016-09-01

    Full Text Available Cyber Physical Social Sensing makes mobile social networks (MSNs popular with users. However, such attacks are rampant as malicious URLs are spread covertly through quick response (QR codes to control compromised accounts in MSNs to propagate malicious messages. Currently, there are generally two types of methods to identify compromised accounts in MSNs: one type is to analyze the potential threats on wireless access points and the potential threats on handheld devices’ operation systems so as to stop compromised accounts from spreading malicious messages; the other type is to apply the method of detecting compromised accounts in online social networks to MSNs. The above types of methods above focus neither on the problems of MSNs themselves nor on the interaction of sensors’ messages, which leads to the restrictiveness of platforms and the simplification of methods. In order to stop the spreading of compromised accounts in MSNs effectively, the attacks have to be traced to their sources first. Through sensors, users exchange information in MSNs and acquire information by scanning QR codes. Therefore, analyzing the traces of sensor-related information helps to identify the compromised accounts in MSNs. This paper analyzes the diversity of information sending modes of compromised accounts and normal accounts, analyzes the regularity of GPS (Global Positioning System-based location information, and introduces the concepts of entropy and conditional entropy so as to construct an entropy-based model based on machine learning strategies. To achieve the goal, about 500,000 accounts of Sina Weibo and about 100 million corresponding messages are collected. Through the validation, the accuracy rate of the model is proved to be as high as 87.6%, and the false positive rate is only 3.7%. Meanwhile, the comparative experiments of the feature sets prove that sensor-based location information can be applied to detect the compromised accounts in MSNs.

  17. National Report presented by the Mexican United States to satisfy the compromises of the Nuclear Safety Convention; Informe Nacional que presentan los Estados Unidos Mexicanos para satisfacer los compromisos de la Convencion de Seguridad Nuclear

    Energy Technology Data Exchange (ETDEWEB)

    National Commission of Nuclear Safety and Safeguards, Mexico City (Mexico); Federal Commission for Electricity, Mexico City (Mexico)

    1998-12-31

    In order to satisfy to the compromises derived of the ratification by part of the Mexican Government for the Nuclear Safety Convention it is presented this National Report which is based on the directives proposed as a result of the preparatory meetings held in the IAEA Headquarters in the city of Vienna, Austria. This National Report represents a document summary and activities realized at present in relation with the only nuclear facility in Mexico: the Nuclear Power Plant in Laguna Verde, Veracruz. This report consists of two parts: In the first one it is described how have been satisfied each one of the compromises. The second one talks about the Laws and Regulations on nuclear activities in the country. (Author)

  18. National Report presented by the Mexican United States to satisfy the compromises of the Nuclear Safety Convention; Informe Nacional que presentan los Estados Unidos Mexicanos para satisfacer los compromisos de la Convencion de Seguridad Nuclear

    Energy Technology Data Exchange (ETDEWEB)

    National Commission of Nuclear Safety and Safeguards, Mexico City (Mexico); Federal Commission for Electricity, Mexico City (Mexico)

    1999-12-31

    In order to satisfy to the compromises derived of the ratification by part of the Mexican Government for the Nuclear Safety Convention it is presented this National Report which is based on the directives proposed as a result of the preparatory meetings held in the IAEA Headquarters in the city of Vienna, Austria. This National Report represents a document summary and activities realized at present in relation with the only nuclear facility in Mexico: the Nuclear Power Plant in Laguna Verde, Veracruz. This report consists of two parts: In the first one it is described how have been satisfied each one of the compromises. The second one talks about the Laws and Regulations on nuclear activities in the country. (Author)

  19. The integrated reporting: A presentation of the current state of art and aspects of integrated reporting that need further development

    OpenAIRE

    Morrós Ribera, Jordi

    2016-01-01

    Purpose: The purpose of this paper is to synthesise what is the emerging field of integrated reporting, with particular emphasis in the International Integrated Reporting Council, and outline a list of items for future research in this area. Design/methodology/approach: The approach is to outline a presentation of integrated reporting (IR), and make a review of the implications for the research agenda of the most important items. Findings: The need for quality researchers to address a number ...

  20. 32 CFR 310.50 - Lost, stolen, or compromised information.

    Science.gov (United States)

    2010-07-01

    ... Official for Privacy within 24 hours of discovering that a breach of personally identifiable information... Privacy Office of the breach within 48 hours upon being notified that a loss, theft, or compromise has... (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Privacy Act Violations § 310.50 Lost, stolen, or compromised...

  1. Physically Compromised and Physically Talented Children in Northeastern Slovenia

    Directory of Open Access Journals (Sweden)

    Planinšec Jurij

    2012-12-01

    Full Text Available The aim of our research was to determine the share of physically compromised and physically talented children in northeastern Slovenia. The sample comprised 621 children aged nine to eleven years, among which there were 316 girls (M=10; SD=0.8 and 305 boys (M=10; SD=0.81. In order to assess their motor skills, seven different tests were used, mostly from Eurofit test battery, which covered explosive power, repetitive power balance, eye–hand coordination, speed of simple movements, whole body coordination, and endurance. The assessment was made for each physical fitness test separately. The cut-off points for determination of physically compromised and physically talented children were set at -1SD and +1SD, respectively. The results of all physical fitness tests showed that the share of physically compromised children exceeded ten percent for both genders. The largest number of boys and girls were physically compromised with regard to endurance and balance, respectively. On the other hand, boys proved to be most physically talented with regard to endurance, and girls with regard to explosive power. Gender differences were most obvious with regard to general endurance, as 21 per cent of the boys were physically compromised as opposed to 13 per cent of the girls. As for physical talent, we observed less gender-related differences. The results indicate increasing differences in physical fitness among children from northeastern Slovenia. The implementation of curricular and extracurricular sports activities should aim at reducing the number of physically compromised children. On the other hand, it would make sense to encourage physically talented children to get involved in organized forms of exercise.

  2. Social and Environmental Reporting as a Part of the Integrated Reporting

    Directory of Open Access Journals (Sweden)

    Mihaela Turturea

    2015-01-01

    Full Text Available Social and environmental aspects, considered valuable factors in decision making process, play an important role within the nowadays complex business environment. Recent accounting literature reveals that the need for disclosing non-financial information is widely debated based on the fact that considerable decisions cannot be supported only by referring to past financial performances. This paper, organized as an empirical study, aims to provide an overall image upon social and environmental disclosures inside the integrated reports of the companies which have taken part for three consecutive years in the International Integrated Reporting Council (IIRC Pilot Programme Business Network.The research is conducted among the integrated reports issued by companies belonging to various industries, coming from France, Germany and United Kingdom. The results achieved show that companies fail to present a complete picture regarding their social and environmental performances and implicitly fail to achieve the intended purpose of the IIRC in promoting the accounting for sustainability. An overall result shows that companies coming from Germany disclose the least social and environmental aspects within integrated reports as compared to British and French organizations.

  3. Discordant results obtained with Francisella tularensis during in vitro and in vivo immunological studies are attributable to compromised bacterial structural integrity.

    Directory of Open Access Journals (Sweden)

    Anju Singh

    Full Text Available Francisella tularensis (Ft is a highly infectious intracellular pathogen and the causative agent of tularemia. Because Ft can be dispersed via small droplet-aerosols and has a very low infectious dose it is characterized as a category A Select Agent of biological warfare. Respiratory infection with the attenuated Live Vaccine Strain (LVS and the highly virulent SchuS4 strain of Ft engenders intense peribronchiolar and perivascular inflammation, but fails to elicit select pro-inflammatory mediators (e.g., TNF, IL-1β, IL-6, IL-12, and IFN-γ within the first ~72 h. This in vivo finding is discordant with the principally TH1-oriented response to Ft frequently observed in cell-based studies wherein the aforementioned cytokines are produced. An often overlooked confounding factor in the interpretation of experimental results is the influence of environmental cues on the bacterium's capacity to elicit certain host responses. Herein, we reveal that adaptation of Ft to its mammalian host imparts an inability to elicit select pro-inflammatory mediators throughout the course of infection. Furthermore, in vitro findings that non-host adapted Ft elicits such a response from host cells reflect aberrant recognition of the DNA of structurally-compromised bacteria by AIM2-dependent and -independent host cell cytosolic DNA sensors. Growth of Ft in Muller-Hinton Broth or on Muller-Hinton-based chocolate agar plates or genetic mutation of Ft was found to compromise the structural integrity of the bacterium thus rendering it capable of aberrantly eliciting pro-inflammatory mediators (e.g., TNF, IL-1β, IL-6, IL-12, and IFN-γ. Our studies highlight the profound impact of different growth conditions on host cell response to infection and demonstrate that not all in vitro-derived findings may be relevant to tularemia pathogenesis in the mammalian host. Rational development of a vaccine and immunotherapeutics can only proceed from a foundation of knowledge based upon

  4. Integrated Reporting: Who Cares?

    OpenAIRE

    Cheok, Mei-Ing

    2013-01-01

    Integrated reporting (IR) is the latest in the evolution of corporate social and environmental disclosures. It seeks the holy grail of gaining mainstream acceptance in the investment community. I investigate and compare the perceptions of the investment community (considered IR’s primary target audience), sustainability experts and internal stakeholders (report producers), using Unilever as a case study. In this research, I find that while IR can help them make better long-term investment or ...

  5. Sarcoidosis with Major Airway, Vascular and Nerve Compromise

    Directory of Open Access Journals (Sweden)

    Hiroshi Sekiguchi

    2013-01-01

    Full Text Available The present report describes a 60-year-old Caucasian woman who presented with progressive dyspnea, cough and wheeze. A computed tomography scan of the chest showed innumerable bilateral inflammatory pulmonary nodules with bronchovascular distribution and a mediastinal and hilar infiltrative process with calcified lymphadenopathy leading to narrowing of lobar bronchi and pulmonary arteries. An echocardiogram revealed pulmonary hypertension. Bronchoscopy showed left vocal cord paralysis and significant narrowing of the bilateral bronchi with mucosal thickening and multiple nodules. Transbronchial biopsy was compatible with sarcoidosis. Despite balloon angioplasty of the left lower lobe and pulmonary artery, and medical therapy with oral corticosteroids, her symptoms did not significantly improve. To the authors’ knowledge, the present report describes the first case of pulmonary sarcoidosis resulting in major airway, vascular and nerve compromise due to compressive lymphadenopathy and suspected concurrent granulomatous infiltration. Its presentation mimicked idiopathic mediastinal fibrosis.

  6. State Program Integrity Review Reports List

    Data.gov (United States)

    U.S. Department of Health & Human Services — Comprehensive state program integrity (PI) review reports (and respective follow-up review reports) provide CMS assessment of the effectiveness of the states PI...

  7. The integrated reporting: A presentation of the current state of art and aspects of integrated reporting that need further development

    Directory of Open Access Journals (Sweden)

    Jordi Morros

    2016-02-01

    Full Text Available Purpose: The purpose of this paper is to synthesise what is the emerging field of integrated reporting, with particular emphasis in the International Integrated Reporting Council, and outline a list of items for future research in this area. Design/methodology/approach: The approach is to outline a presentation of integrated reporting (IR, and make a review of the implications for the research agenda of the most important items. Findings: The need for quality researchers to address a number of pressing challenges posed by the rapid development of IR policies and practices. Research limitations/implications: The paper provide insights into issues and aspects of integrated reporting that need further development and need robust evidence to help inform improvements in policy and practice. Practical implications: Highlight how companies may benefit from integrated reporting in response to stakeholders’ calls for enhanced disclosure of environmental, social, governance and other non financial information. Social implications: The main social implication is to promote the wider public interest of improving the relevance of information for decision-making, for all stakeholders, and allow greater efficiency in the allocation of financial and other resources and in adding public value Originality/value: This paper offers a general view on a subject that is a challenge for entities oriented to the implementation of sustainability in their values and also in their reporting.

  8. THE MANAGEMENT ACCOUNTING TOOLS AND THE INTEGRATED REPORTING

    Directory of Open Access Journals (Sweden)

    Gabriel JINGA

    2015-04-01

    Full Text Available During the recent years the stakeholders are asking for other pieces of information to be published along with the financial one, such as risk reporting, intangibles, social and environmental accounting. The type of corporate reporting which incorporates the elements enumerated above is the integrated reporting. In this article, we argue that the information disclosed in the integrated reports is prepared by the management accounting, not only by the financial accounting. Thus, we search for the management accounting tools which are used by the companies which prepare integrated reports. In order to do this, we analytically reviewed all the reports available on the website of a selected company. Our results show that the company is using most of the management accounting tools mentioned in the literature review part.

  9. Compromised Agency: The Case of BabyLegs

    Directory of Open Access Journals (Sweden)

    Max Liboiron

    2017-09-01

    Full Text Available The concept of agency is ubiquitous in STS, particularly regarding cases of alternative ways of knowing and doing science such as civic, citizen, and feminist sciences, among others. Yet the focus on agency often glosses over the constraints placed on agents, particularly within asymmetrical power relations. This article follows the case of BabyLegs, a do-it-yourself monitoring tool for marine microplastic pollution, and the attempt to keep the technology open source within an intellectual property (IP system set up to privatize it. The tactics used to design BabyLegs as a feminine, silly, doll-tool to discredit the device in the eyes of an IP system that valued traditional gender roles lead to the eventual success of keeping the device open source. Yet, those same tactics also reinforced and reproduced the structures of power and essentialism they were designed to resist. I characterize this technological ambivalence as compromise, and argue that all agency exercised within asymmetrical power relations is compromised. This is not to say resistance is futile, but that agency is never pure, and this recognition lets us be more intentional in how we might compromise as practitioners of diverse scientific knowledges.

  10. Management of compromised anterior maxillary edentulous arch with symphyseal bone graft

    Directory of Open Access Journals (Sweden)

    Sunil Kumar Mishra

    2018-01-01

    Full Text Available Achieving optimal aesthetics, function and phonetics with implant-supported restorations depends largely on the amount of bone present at the site where implant has to be placed. Sometimes, patient reports with compromised conditions which makes the implant placement difficult. Today, reconstruction procedures such as autogenous bone graft and guided bone regeneration make the implant placement possible in different ridge deficient cases. This case report describes step-by-step procedure of restoring the missing maxillary right central incisor with implant-supported prostheses. In missing left central incisor region, the alveolar bony defect was corrected by autogenous bone graft obtained from symphysis region, for restoration with implant prostheses.

  11. Compromise decision support problems for hierarchical design involving uncertainty

    Science.gov (United States)

    Vadde, S.; Allen, J. K.; Mistree, F.

    1994-08-01

    In this paper an extension to the traditional compromise Decision Support Problem (DSP) formulation is presented. Bayesian statistics is used in the formulation to model uncertainties associated with the information being used. In an earlier paper a compromise DSP that accounts for uncertainty using fuzzy set theory was introduced. The Bayesian Decision Support Problem is described in this paper. The method for hierarchical design is demonstrated by using this formulation to design a portal frame. The results are discussed and comparisons are made with those obtained using the fuzzy DSP. Finally, the efficacy of incorporating Bayesian statistics into the traditional compromise DSP formulation is discussed and some pending research issues are described. Our emphasis in this paper is on the method rather than the results per se.

  12. Near-infrared spectroscopy for detection of vascular compromise in paediatric supracondylar fractures

    International Nuclear Information System (INIS)

    Skowno, Justin J; De Lima, Jonathan; Quick, Tom J; Carpenter, Eleanor C; Gibbons, Paul J; Little, David G

    2014-01-01

    Children suffering supracondylar fractures of the humerus are at risk of vascular compromise, which is currently assessed clinically, although other modalities such as angiography, pulse oximetry, Doppler ultrasound and magnetic resonance angiography have been used. We sought to ascertain whether tissue haemoglobin oxygenation (StO 2 ) measurement could distinguish between patients with and without clinical vascular compromise following supracondylar fractures of the humerus. We prospectively observed StO 2  using near-infrared spectroscopy in 29 paediatric patients with supracondylar fractures requiring operative manipulation. The injured and uninjured volar forearm compartments were monitored immediately before and after fracture reduction. The relationship between StO 2  in the injured and uninjured limb, and the presence of pre-operative vascular compromise was assessed. Seven out of 29 children presented with vascular compromise. Patients with clinical vascular compromise had significantly lower pre-reduction StO 2  (63.5% ± 15%, mean ± standard deviation), compared to those without compromise (80.9% ± 10%). StO 2  normalized following surgery in all children with vascular compromise. These improvements in muscle StO 2  were associated, in all patients, with the clinical return of pulses and resolution of neurological symptoms if present. StO 2  monitoring can identify patients with clinical vascular compromise, can identify the return of adequate perfusion following operative correction of supracondylar fractures, and may be a useful adjunct to clinical assessment. (paper)

  13. When data representation compromise data security

    DEFF Research Database (Denmark)

    Simonsen, Eivind Ortind; Dahl, Mads Ronald

    WHEN DATA REPRESENTATION COMPROMISE DATA SECURITY The workflow of transforming data into informative representations makes extensive usage of computers and software. Scientists have a conventional tradition for producing publications that include tables and graphs as data representations....... These representations can be used for multiple purposes such as publications in journals, teaching and conference material. But when created, stored and distributed in a digital form there is a risk of compromising data security. Data beyond the once used specifically to create the representation can be included...... on the internet over many years? A new legislation proposed in 2012 by the European Commission on protection of personal data will be implemented from 2015. The new law will impose sanction options ranging from a warning to a fine up to 100.000.000 EUR. We argue that this new law will lead to especially...

  14. Integrated Sustainability Reporting at HNE Eberswalde--A Practice Report

    Science.gov (United States)

    Kräusche, Kerstin; Pilz, Stefanie

    2018-01-01

    Purpose: The purpose of this paper is to present the development of an integrated sustainability reporting. In this paper success criteria are named and empirical values when dealingwith specific challenges are formulated. The focus is on the development of criteria for reporting, the involvement of university members and quality assurance.…

  15. Tax Administration: IRS Should Evaluate the Changes to Its Offer in Compromise Program

    National Research Council Canada - National Science Library

    2002-01-01

    ...) Offer in Compromise (OIC) Program. An offer in compromise is an agreement between a taxpayer and the IRS to settle or compromise the taxpayer's tax liability for less than the full amount owed...

  16. Senior executives' perspectives of integrated reporting regulatory ...

    African Journals Online (AJOL)

    kirstam

    2014-12-09

    Dec 9, 2014 ... that integrated thinking and integrated reporting principles will have ... in response to financial, governance and other crises; heightened expectations of ... The Prince's Accounting for Sustainability Project suggests a concept.

  17. Objections to the Libertarian Stem Cell Compromise

    Directory of Open Access Journals (Sweden)

    Walter E. Block

    2010-11-01

    Full Text Available In Block (2010 I offered a compromise between the pro choice position that fervently supports stem cell research, and the pro life philosophy which bitterly opposes it. The compromise was a contest: allow would be researchers to create as many fertilized eggs as they wished. But, also, these should be offered up to would be parents to adopt all of these “children” as they wanted. If and only if there were any unadopted fetuses remaining in the laboratories of the nation would it be licit, on libertarian grounds, for research on them to take place. In the present paper I respond to several objections to this “modest proposal.”

  18. The social-financial responsible reporting – the key for integrated reporting

    Directory of Open Access Journals (Sweden)

    Iulia Jianu

    2012-08-01

    Full Text Available General purpose of financial statements is to satisfy the needs of users who are not in the position to require of the entity to prepare reports tailored to their particular information needs. Because the public is one of these users interested of social information and because the financial statement do not provide sufficient social information to satisfy these needs, the study demonstrate the need to integrate the responsible social reporting into financial reporting. In order to support this reason, taking into account the data supplied by the entities listed on the Global Reporting Initiative regarding the corporate social responsibility. The results of the study show that social indicators can be disclosed in a monetary form which reinforces the need for their integration into financial reporting and the need to define a new concept: the social – financial responsible reporting.

  19. Aspects regarding the adoption and development of integrated reporting practices

    Directory of Open Access Journals (Sweden)

    Lapteș Ramona

    2018-01-01

    Full Text Available The current economic context brings about new challenges and responsibilities that companies have to face in the communication area based on the principle of sustainable development. This refers to both- protecting the interests of all economic agents involved and minimizing the aggression on natural resources. Hence, entities’ communication process was reconsidered in the form of integrated reporting. This relatively new type of reporting is continuously under evelopment at an international level and it was better understood in practice through the Integrated Reporting Pilot Programme . This paper aims to present the integrated reporting practices of Danone, one of the members of the Pilot Programme through a case study approach. Notwithstanding the experience it should have in the integrated reporting area, o ur findings show that Danone issued a document entitled “Integrated report” only in 2016. Until this year, the firm cho se to publish two reports related to economic and social issues and sustainability, rather combined than integrated.

  20. 7 CFR 1956.68 - Compromise or adjustment without debtor's signature.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Compromise or adjustment without debtor's signature... Loan Programs and Multi-Family Housing § 1956.68 Compromise or adjustment without debtor's signature... made to obtain the debtor's signature and the date(s) of such effort. (c) The specific reasons why it...

  1. 32 CFR 842.99 - Compromise, termination, and suspension of collection.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Compromise, termination, and suspension of collection. 842.99 Section 842.99 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR... States (31 U.S.C. 3701, 3711-3719) § 842.99 Compromise, termination, and suspension of collection. This...

  2. 10 CFR 15.41 - When a claim may be compromised.

    Science.gov (United States)

    2010-01-01

    ... it has not been referred to DOJ for litigation. (b) Unless otherwise provided by law, when the... with the DOJ. The NRC will evaluate the compromise offer, using the factors set forth in this part. If an offer to compromise any debt in excess of $100,000 is acceptable to the NRC, the NRC shall refer...

  3. ClearFuels-Rentech Integrated Biorefinery Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Pearson, Joshua [Project Director

    2014-02-26

    The project Final Report describes the validation of the performance of the integration of two technologies that were proven individually on a pilot scale and were demonstrated as a pilot scale integrated biorefinery. The integrated technologies were a larger scale ClearFuels’ (CF) advanced flexible biomass to syngas thermochemical high efficiency hydrothermal reformer (HEHTR) technology with Rentech’s (RTK) existing synthetic gas to liquids (GTL) technology.

  4. Strained Compromises? Danish Flexicurity During Crisis

    DEFF Research Database (Denmark)

    Ibsen, Christian Lyhne

    2011-01-01

    The Danish concept of flexicurity in a ‘Golden Triangle’ of low job protection, high income security and high employment security is not only about a balance between labor market flexibility and social security. Arguably, it is also a series of more or less stable underlying compromises between...

  5. Taking a Bad Turn: Compromised DNA Damage Response in Leukemia

    Directory of Open Access Journals (Sweden)

    Nadine Nilles

    2017-05-01

    Full Text Available Genomic integrity is of outmost importance for the survival at the cellular and the organismal level and key to human health. To ensure the integrity of their DNA, cells have evolved maintenance programs collectively known as the DNA damage response. Particularly challenging for genome integrity are DNA double-strand breaks (DSB and defects in their repair are often associated with human disease, including leukemia. Defective DSB repair may not only be disease-causing, but further contribute to poor treatment outcome and poor prognosis in leukemia. Here, we review current insight into altered DSB repair mechanisms identified in leukemia. While DSB repair is somewhat compromised in all leukemic subtypes, certain key players of DSB repair are particularly targeted: DNA-dependent protein kinase (DNA-PK and Ku70/80 in the non-homologous end-joining pathway, as well as Rad51 and breast cancer 1/2 (BRCA1/2, key players in homologous recombination. Defects in leukemia-related DSB repair may not only arise from dysfunctional repair components, but also indirectly from mutations in key regulators of gene expression and/or chromatin structure, such as p53, the Kirsten ras oncogene (K-RAS, and isocitrate dehydrogenase 1 and 2 (IDH1/2. A detailed understanding of the basis for defective DNA damage response (DDR mechanisms for each leukemia subtype may allow to further develop new treatment methods to improve treatment outcome and prognosis for patients.

  6. Community for Data Integration 2016 annual report

    Science.gov (United States)

    Langseth, Madison L.; Hsu, Leslie; Amberg, Jon J.; Bliss, Norman; Bock, Andrew R.; Bolus, Rachel T.; Bristol, R. Sky; Chase, Katherine J.; Crimmins, Theresa M.; Earle, Paul S.; Erickson, Richard; Everette, A. Lance; Falgout, Jeff T.; Faundeen, John L.; Fienen, Michael N.; Griffin, Rusty; Guy, Michelle R.; Henry, Kevin D.; Hoebelheinrich, Nancy J.; Hunt, Randall; Hutchison, Vivian B.; Ignizio, Drew A.; Infante, Dana M.; Jarnevich, Catherine; Jones, Jeanne M.; Kern, Tim; Leibowitz, Scott; Lightsom, Francis L.; Marsh, R. Lee; McCalla, S. Grace; McNiff, Marcia; Morisette, Jeffrey T.; Nelson, John C.; Norkin, Tamar; Preston, Todd M.; Rosemartin, Alyssa; Sando, Roy; Sherba, Jason T.; Signell, Richard P.; Sleeter, Benjamin M.; Sundquist, Eric T.; Talbert, Colin B.; Viger, Roland J.; Weltzin, Jake F.; Waltman, Sharon; Weber, Marc; Wieferich, Daniel J.; Williams, Brad; Windham-Myers, Lisamarie

    2017-05-19

    The Community for Data Integration (CDI) represents a dynamic community of practice focused on advancing science data and information management and integration capabilities across the U.S. Geological Survey and the CDI community. This annual report describes the various presentations, activities, and outcomes of the CDI monthly forums, working groups, virtual training series, and other CDI-sponsored events in fiscal year 2016. The report also describes the objectives and accomplishments of the 13 CDI-funded projects in fiscal year 2016.

  7. Striking a Balance between Program Requirements and GT Principles: Writing a compromised GT proposal

    Directory of Open Access Journals (Sweden)

    Sherry L. Xie, Ph.D. Candidate

    2009-06-01

    Full Text Available Glaser’s term “compromised GT proposal” (2001, p.114 refers to the type of Grounded Theory (GT proposal that is written in order to conform to the requirements of a standardized qualitative research proposal. A GT proposal needs only to supply information on the area of interest, the data source and a statement of method to the effect that the researcher begin to collect, code and analyse the data and let the theory emerge. Thus, the proposal may only occupy “a page or two” (Glaser, 2001, p. 111. Whilst being consistent with the methodology, a GT proposal sometimes has to give way to the format specified by a PhD program or committee even though the format was not defined for a GT proposal and in some areas, conflicts with GT principles; for example, the format may require a literature review. This short paper reports on my experience of writing a compromised GT proposal as a first-time GT researcher. It describes how both Glaser’s advice on writing compromised GT research proposals and the characteristics of the substantive area of the proposed research were used to satisfy program requirements while still maintaining GT fundamentals.

  8. Securing Single Points of Compromise (SPoC)

    Energy Technology Data Exchange (ETDEWEB)

    Belangia, David Warren [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-06-25

    Securing the Single Points of Compromise that provide central services to the institution’s environment is paramount to success when trying to protect the business. (Fisk, 2014) Time Based Security mandates protection (erecting and ensuring effective controls) that last longer than the time to detect and react to a compromise. When enterprise protections fail, providing additional layered controls for these central services provides more time to detect and react. While guidance is readily available for securing the individual critical asset, protecting these assets as a group is not often discussed. Using best business practices to protect these resources as individual assets while leveraging holistic defenses for the group increases the opportunity to maximize protection time, allowing detection and reaction time for the SPoCs that is commensurate with the inherent risk of these centralized services.

  9. Development of the Conceptual Basis for Enterprise Integrated Reporting

    Directory of Open Access Journals (Sweden)

    Budko Oksana V.

    2017-09-01

    Full Text Available The aim of the article is to study the conceptual basis for integrated reporting in terms of its drafting principles, taking into account the need to satisfy the information requests of interested parties regarding the company’s value in the long run and the level of implementation of its sustainable development strategy. As a result of the study, the goals of integrated reporting are defined, with consideration for the sustainable development strategy chosen by the company, which can be achieved by accomplishing tasks, among which a special role is played by the support of integrated thinking at making decisions about creating value in the short, medium and long term. It is indicated that the basis for preparing integrated reports is the use of clearly defined principles, both in respect to their list and content. The composition of the principles specified in the International Integrated Reporting Framework (IIRF is analyzed, and it is found that some of them require clarifying (strategic focus and future orientation, or defining as part of quality characteristics or requirements (reliability, comparability, interaction with stakeholders. The list of leading (basic principles is supplemented with additional principles (synergism, neutrality, efficiency, validity, logicality, the observance of which will ensure an increase in the value and content of integrated reporting. A prospect for further research is analysis of the defined by ISIR integrated reporting structure that requires improvement in part of the list of sections and their content, and will take into account the need to provide information in the interdependence of factors of economic, environmental and social influence and financial indicators in making decisions by stakeholders.

  10. KEY PERFORMANCE INDICATORS DISCLOSURES BY THE INTEGRATED REPORTING

    Directory of Open Access Journals (Sweden)

    BOBITAN ROXANA-IOANA

    2016-02-01

    Full Text Available We are in a new era of corporate reporting where the corporate reporting landscape was changed. Institutional and small investors, financial analysts and other key stakeholders are demanding more information about long-term strategies and profitability of companies. Also, the increasing complexity of business models, growing awareness of climate change and resource scarcity and communication are expectations of the role of business in the 21st century and which the key of performance indicators (KPIs is. The companies must change the way these KPIs are being incorporated throughout the annual report and how these are linked to the company’s strategy and business model, their risks and risk mitigation, and their incentive schemes. Regarding this, integrated reporting, continue to gain momentum, the spotlight on the depth, breadth and quality of KPIs being reported will only strengthen. The aim of this discussion paper is to describe which are the most important key performance indicators in sprit of integrating reporting. A good and very known example for the integrated reporting is Philips Electronics, the Dutch healthcare and lighting company, a pioneer that embrace this concept, and the paper make an analysis of the most important key performance indicators.

  11. Alchemy or Science? Compromising Archaeology in the Deep Sea

    Science.gov (United States)

    Adams, Jonathan

    2007-06-01

    In the torrid debate between archaeology and treasure hunting, compromise is often suggested as the pragmatic solution, especially for archaeology carried out either in deep water or beyond the constraints that commonly regulate such activities in territorial seas. Both the wisdom and the need for such compromise have even been advocated by some archaeologists, particularly in forums such as the internet and conferences. This paper argues that such a compromise is impossible, not in order to fuel confrontation but simply because of the nature of any academic discipline. We can define what archaeology is in terms of its aims, theories, methods and ethics, so combining it with an activity founded on opposing principles must transform it into something else. The way forward for archaeology in the deep sea does not lie in a contradictory realignment of archaeology’s goals but in collaborative research designed to mesh with emerging national and regional research and management plans.

  12. Esthetic management of compromised ridge in the anterior maxilla, a modified prosthetic approach

    Directory of Open Access Journals (Sweden)

    R Lambodharan

    2017-01-01

    Full Text Available Replacing a missing tooth with an implant, especially in the esthetic zone has been increasing demand for the patient. Placing dental implants in the esthetic zone, especially in the compromised ridge with thin gingival thin biotype is considered to be the ultimate challenge for many dentists. This case report illustrates the implant placement in the traumatic anterior maxilla with thin gingival biotype (Class IV and a modified approach in prosthetic placement.

  13. Strained Compromises? Danish Flexicurity During Crisis

    Directory of Open Access Journals (Sweden)

    Christian Lyhne Ibsen

    2011-01-01

    Full Text Available The Danish concept of flexicurity in a `Golden Triangle´ of low job protection, high income security and high employment security is not only about a balance between labor market flexibility and social security. Arguably, it is also a series of more or less stable underlying compromises between social partners about the main mechanisms and aims of labor market regulation which - supposedly - should be focused on employment rather than jobs, and competition on quality rather than on labor costs. However, the `Golden Triangle´ - this article argues - seems in need of complementary concepts. The article therefore introduces, `centralized decentralization´ - a concept that directs our attention to forms of flexibility and security primarily for people in work. Most studies on Danish flexicurity have been carried out under favorable economic conditions. In light of the economic slump hitting Denmark in 2008, this article investigates if and how the recession challenged these compromises by comparing two rounds of case-based interviews in three metalworking companies in 2007 and 2009. It is shown that practice has indeed changed - albeit modestly - due to worsened economic circumstances. For example the case studies show that the hypothesized preference for external numerical flexibility is perhaps too crude as employers use different ways to restructure employment. Especially the examples of de facto concessionary bargaining to save jobs are important here - although the extent of concessions is modest. The evidence thus suggests that the `Golden Triangle´ flexicurity compromises are indeed strained by the economic cycle and that responses to impetus for restructuring are far more nuanced than sometimes portrayed. It is argues that more company studies across national labor markets and industrial relations institutions will enhance our understanding of the dynamics during times of restructuring.

  14. September 2016 Bayou Choctaw Subsidence Report

    Energy Technology Data Exchange (ETDEWEB)

    Moriarty, Dylan Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lord, Anna C. Snider [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-05-01

    Subsidence monitoring is a crucial component to understanding cavern integrity of salt storage caverns. This report looks at historical and current data at the Bayou Choctaw Strategic Petroleum Reserve Site. Data from the most recent land-based annual surveys, GPS, and tiltmeter indicate the subsidence rates across the site are approximately 0.0 ft./yr. Because of this, there is no evidence from the subsidence survey to suggest any of the DOE caverns have been structurally compromised.

  15. Preliminary Integrated Safety Analysis Status Report

    International Nuclear Information System (INIS)

    Gwyn, D.

    2001-01-01

    This report provides the status of the potential Monitored Geologic Repository (MGR) Integrated Safety Analysis (EA) by identifying the initial work scope scheduled for completion during the ISA development period, the schedules associated with the tasks identified, safety analysis issues encountered, and a summary of accomplishments during the reporting period. This status covers the period from October 1, 2000 through March 30, 2001

  16. COMPROMISE EFFECT ON CONSUMERS’ BEHAVIOR

    Directory of Open Access Journals (Sweden)

    Markus Surkamta Eric Santosa

    2016-09-01

    Full Text Available The way consumers think about the products they will buy determines their buying behavior. The decision to buy a particular product is obviously in accordance with the buyer’s attitude. The buyers will also feel more comfortable if their behavior meets with the approval and expectations of the people close to them. While the development of a certain attitude has no effect on subjective judgment, the effect of compromise is likely to make a contribution to its development. Since it is still unclear, this study’s main purposed is to clarify this. In addition, while an attitude is theorized as being a predictor of behavior, through behavioral intention, the study’s secondary purpose is to boost the earlier findings. Likewise, in accordance with the theory of planned behavior, the study will also examine the other predictors of behavioral intention, in relation to the behavioral intention itself. A sample consisting of a 100 respondents was compiled by using the convenience and judgment technique. The data were analyzed using Amos 16.0 and SPSS 16.0. As expected, the compromise effect had a significant influence on whether the customers’ attitude or the subjective norm was the main determinant. Likewise, the customers’ attitude, the subjective norm and perceived behavioral control were confirmed as good predictors of customers’ behavioral intentions.

  17. Integrated safety assessment report: Integrated Safety Assessment Program: Millstone Nuclear Power Station, Unit 1 (Docket No. 50-245): Draft report

    International Nuclear Information System (INIS)

    1987-04-01

    The Integrated Safety Assessment Program (ISAP) was initiated in November 1984, by the US Nuclear Regulatory Commission to conduct integrated assessments for operating nuclear power reactors. The integrated assessment is conducted in a plant-specific basis to evaluate all licensing actions, licensee initiated plant improvements and selected unresolved generic/safety issues to establish implementation schedules for each item. In addition, procedures will be established to allow for a periodic updating of the schedules to account for licensing issues that arise in the future. This report documents the review of Millstone Nuclear Power Station, Unit No. 1, operated by Northeast Nuclear Energy Company (located in Waterford, Connecticut). Millstone Nuclear Power Station, Unit No. 1, is one of two plants being reviewed under the pilot program for ISAP. This report indicates how 85 topics selected for review were addressed. This report presents the staff's recommendations regarding the corrective actions to resolve the 85 topics and other actions to enhance plant safety. The report is being issued in draft form to obtain comments from the licensee, nuclear safety experts, and the Advisory Committee for Reactor Safeguards (ACRS). Once those comments have been resolved, the staff will present its positions, along with a long-term implementation schedule from the licensee, in the final version of this report

  18. MUTUAL CONCESSIONS - SPECIFIC ELEMENT OF THE COMPROMISE/TRANSACTION CONTRACT

    Directory of Open Access Journals (Sweden)

    Georgeta-Bianca Spîrchez

    2012-11-01

    Full Text Available Given the usefulness and practical importance of the compromise contract conclusion and of the amicably dispute resolution, within the business world, we aim to analyze, in what follows, the concrete means by which these kind of settlement are achieved. Two questions become legitimate in the context of concerns about mutual concessions which the parties make in a compromise contract. These questions are the following: “What are the mutual concessions? Do mutual concessions mean equivalent concessions?” and “How mutual concessions are required to complete a valid settlement? Is the requirement of mutual concessions grounded?”

  19. Knowledge is power: averting safety-compromising events in the OR.

    Science.gov (United States)

    Catalano, Kathleen

    2008-12-01

    Surgical procedures can be unpredictable, and safety-compromising events can jeopardize patient safety. Perioperative nurses should be watchful for factors that can contribute to safety-compromising events, as well as the errors that can follow, and know how to avert them if possible. Knowledge is power and increased awareness of patient safety issues and the resources that are available to both health care practitioners and consumers can help perioperative nurses ward off patient safety problems before they occur.

  20. Vatican is lone opponent of world conference's compromises on abortion.

    Science.gov (United States)

    1994-09-07

    Three years in the making, the draft program of action of the 1994 International Conference on Population and Development sets nonbinding policy guidelines to contain the world's population at 7.27 billion in 2015. Although the Vatican was pleased to see Pakistan put forward a compromise formula developed to appease Catholic and Muslim objectors of abortion, the Church was unprepared to accept the compromise immediately and requested further discussion. The Vatican's rejection drew a strong chorus of vocal disapproval from other conference delegates. Even Iran accepted the draft as a "perfect text," while Sweden grudgingly accepted it as a "rock-bottom compromise." With no Catholic countries objecting to the compromise, the Vatican stood alone in its refusal to compromise with the rest of the world's leaders and peoples. Germany, speaking for the European Union, warned that enough concessions had already been made. The rationale for Vatican opposition was unclear since the section explicitly rejects abortion as a means of family planning and urges countries to minimize both the incidence of unsafe abortion and abortion overall by improving family planning. Prevention of unwanted pregnancies must be given highest priority and women should have ready access to compassionate counselling, with abortion never promoted as a means of family planning. Moreover, there is no longer a reference to sexual health education, a plea to governments to review their laws and policies on abortion, and a call to consider women's health rather than relying upon criminal codes and punitive measures. Participants said the Vatican objected to a phrase stating that abortions, where legal, should be safe, while the Church representative argued that any suggestion that abortion is safe contradicts church doctrine on the sanctity of life.

  1. Constraining the brachial plexus does not compromise regional control in oropharyngeal carcinoma

    International Nuclear Information System (INIS)

    Robert, Mutter W; Wolden, Suzanne L; Lee, Nancy Y; Lok, Benjamin H; Dutta, Pinaki R; Riaz, Nadeem; Setton, Jeremy; Berry, Sean L; Goenka, Anuj; Zhang, Zhigang; Rao, Shyam S

    2013-01-01

    Accumulating evidence suggests that brachial plexopathy following head and neck cancer radiotherapy may be underreported and that this toxicity is associated with a dose–response. Our purpose was to determine whether the dose to the brachial plexus (BP) can be constrained, without compromising regional control. The radiation plans of 324 patients with oropharyngeal carcinoma (OPC) treated with intensity-modulated radiation therapy (IMRT) were reviewed. We identified 42 patients (13%) with gross nodal disease <1 cm from the BP. Normal tissue constraints included a maximum dose of 66 Gy and a D 05 of 60 Gy for the BP. These criteria took precedence over planning target volume (PTV) coverage of nodal disease near the BP. There was only one regional failure in the vicinity of the BP, salvaged with neck dissection (ND) and regional re-irradiation. There have been no reported episodes of brachial plexopathy to date. In combined-modality therapy, including ND as salvage, regional control did not appear to be compromised by constraining the dose to the BP. This approach may improve the therapeutic ratio by reducing the long-term risk of brachial plexopathy

  2. Adolescent Health-Compromising Behaviors: Motivating School Counselors.

    Science.gov (United States)

    Nagel, Liza; Scherer, David G.; Lee, William

    2000-01-01

    Investigated middle and high school counselors' perceptions of adolescent health-compromising behaviors and motivations to intervene. Data from a survey based on protection motivation theory showed differences in counselors' perceptions of the severity of risk-taking behaviors. Perceptions were highly correlated with intentions to seek out…

  3. Predicting intrapartum fetal compromise using the fetal cerebro-umbilical ratio.

    Science.gov (United States)

    Sabdia, S; Greer, R M; Prior, T; Kumar, S

    2015-05-01

    The aim of this study was to explore the association between the cerebro-umbilical ratio measured at 35-37 weeks and intrapartum fetal compromise. This retrospective cross sectional study was conducted at the Mater Mothers' Hospital in Brisbane, Australia. Maternal demographics and fetal Doppler indices at 35-37 weeks gestation for 1381 women were correlated with intrapartum and neonatal outcomes. Babies born by caesarean section or instrumental delivery for fetal compromise had the lowest median cerebro-umbilical ratio 1.60 (IQR 1.22-2.08) compared to all other delivery groups (vaginal delivery, emergency delivery for failure to progress, emergency caesarean section for other reasons or elective caesarean section). The percentage of infants with a cerebro-umbilical ratio cerebro-umbilical ratio between the 10th-90th centile and 9.6% of infants with a cerebro-umbilical ratio > 90th centile required delivery for the same indication (p cerebro-umbilical ratio was associated with an increased risk of emergency delivery for fetal compromise, OR 2.03 (95% CI 1.41-2.92), p cerebro-umbilical ratio measured at 35-37 weeks is associated with a greater risk of intrapartum compromise. This is a relatively simple technique which could be used to risk stratify women in diverse healthcare settings. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. The medically compromised patient: Are dental implants a feasible option?

    Science.gov (United States)

    Vissink, A; Spijkervet, Fkl; Raghoebar, G M

    2018-03-01

    In healthy subjects, dental implants have evolved to be a common therapy to solve problems related to stability and retention of dentures as well as to replace failing teeth. Although dental implants are applied in medically compromised patients, it is often not well known whether this therapy is also feasible in these patients, whether the risk of implant failure and developing peri-implantitis is increased, and what specific preventive measures, if any, have to be taken when applying dental implants in these patients. Generally speaking, as was the conclusion by the leading review of Diz, Scully, and Sanz on placement of dental implants in medically compromised patients (J Dent, 41, 2013, 195), in a few disorders implant survival may be lower, and the risk of a compromised peri-implant health and its related complications be greater, but the degree of systemic disease control outweighs the nature of the disorder rather than the risk accompanying dental implant treatment. So, as dental implant treatment is accompanied by significant functional benefits and improved oral health-related quality of life, dental implant therapy is a feasible treatment in almost any medically compromised patient when the required preventive measures are taken and follow-up care is at a high level. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.

  5. 14 CFR 1261.414 - Compromise of claims.

    Science.gov (United States)

    2010-01-01

    ... potential income; (3) Inheritance prospects; (4) The possibility that assets have been concealed or... compromised. The practical benefits of vigorous collection of a small claim may include a demonstration to... requiring a waiver of the tax-loss-carry-back rights of the debtor. (i) Joint and several liability. When...

  6. 31 CFR 902.2 - Bases for compromise.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Bases for compromise. 902.2 Section 902.2 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FEDERAL CLAIMS... necessary to further an enforcement principle, such as the Government's willingness to pursue aggressively...

  7. B Plant low level waste system integrity assessment report

    International Nuclear Information System (INIS)

    Walter, E.J.

    1995-09-01

    This document provides the report of the integrity assessment activities for the B Plant low level waste system. The assessment activities were in response to requirements of the Washington State Dangerous Waste Regulations, Washington Administrative Code (WAC), 173-303-640. This integrity assessment report supports compliance with Hanford Federal Facility Agreement and Consent Order interim milestone target action M-32-07-T03

  8. The probable effect of integrated reporting on audit quality

    Directory of Open Access Journals (Sweden)

    Tamer A. El Nashar

    2016-06-01

    Full Text Available This paper examines a probable effect of integrated reporting on improving the audit quality of organizations. I correlate the hypothesis of this paper in relation to the current trends of protecting the economies, the financial markets and the societies. I predict an improvement of the audit quality, as a result to an estimated percentage of organizations’ reliance on the integrated reporting in their accountability perspective. I used a decision tree and a Bayes’ theorem approach, to predict the probabilities of the significant effect on improving the auditing quality. I find the overall result of this paper, indicates that the probability of organizations to rely on the integrated reporting by a significant percentage, predicts also a significant improvement in audit quality.

  9. Factors influencing treatment decision-making for maintaining or extracting compromised teeth.

    Science.gov (United States)

    Lang-Hua, Bich Hue; McGrath, Colman P J; Lo, Edward C M; Lang, Niklaus P

    2014-01-01

    To evaluate treatment decision-making with respect to maintaining periodontally compromised teeth among dentists with or without postgraduate qualifications in implant dentistry. A series of patient scenarios with varying degrees of periodontal disease levels was presented to dental practitioners. Practitioners' decision-making outcome was determined, and intention to retain the compromised teeth was analyzed in bivariate and regression analyses (accounting for postgraduate implant training, gender, years in dental practice, and implant placement experience). This study involved 30 dental practitioners with postgraduate implant qualifications (GDPP), 33 dental practitioners without postgraduate implant qualifications (GDP), and 27 practitioners undergoing training for postgraduate implant qualifications (GDPT). Variations in treatment decision-making were evident between the three groups. Differences in treatment approaches to retaining compromised teeth were apparent. Furthermore, variations in rehabilitation of extracted scenarios existed in terms of use of implant and number of implants need for rehabilitation. Accounting for dentist and practice factors in regression analyses, GDPP/GDPT were three times as likely to retain periodontally compromised upper molar, with or without pain, compared to GDP (without pain OR 3.10, 95%CI 1.04, 10.62 P = 0.04; with pain OR 3.08, 95%CI 1.09, 8.14 P = 0.03). Variations in treatment decision-making with respect to retaining periodontally compromised teeth exist between dental practitioners with and those without postgraduate training in implant dentistry. Furthermore differences in management approaches in how they would retain the teeth or rehabilitate the dental arch were apparent. © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.

  10. Orthodontic management of a periodontally compromised dentition

    Directory of Open Access Journals (Sweden)

    Prashant K Zaveri

    2016-01-01

    Full Text Available Malocclusion superimposed with severe periodontitis may present a great challenge to clinicians while providing orthodontic treatment due the episodic and site-specific nature of the disease with risk of rapid tissue breakdown. However, orthodontic treatment in such situation may contribute significantly to the overall rehabilitation both functionally and esthetically. In this article, a case report outlines a combined periodontic-orthodontic management of compromised dentition. A 37-year-old female patient with significant medical history was treated for Class II Division 1 type of malocclusion associated with spaced upper and lower anterior teeth, deep overbite, and increased overjet, superimposed with chronic generalized periodontitis and bone loss. Treatment was completed using temporary anchorage devices assisted strategically applied force and modified tandem retraction biomechanics amidst management of acute inflammatory episodes during and mucogingival complication after treatment. Affected areas healed very well after post-orthodontic periodontal treatment with minimal pocket depth, and bleeding on probing, and a healthy zone of attached gingiva at the follow up visits. The orthodontic results lead to improvement in patient's facial profile, lip posture, and correction of protrusion which addressed her main concern. One year follow-up shows good orthodontic and periodontic stability. The report highlights the importance of identifying “at risk” individuals and continuous monitoring of disease status during treatment. Despite all precautionary measures, a flare-up during the treatment can be anticipated.

  11. Organizational and methodical approaches to disclosure of income distribution in integrated reporting

    Directory of Open Access Journals (Sweden)

    Legenchyk S.F.

    2017-08-01

    Full Text Available The essence of the integrated reporting is described. Preconditions and problems when introducing the integrated reporting are presented. The information requests of integrated reporting users are described. The necessity of reflection of all types of capital, namely, natural, social, human and intellectual in the integrated reporting are revealed. The main advantages of compiling the integrated accounts for the enterprise are established: a broader perspective of consideration of the activity; the improvement of accounting policy as a result of integration of the principles of sustainable development into activity; increasing the trust of workers and consumers in the safety of technological processes and products for environment. For the wider introduction of the integrated reporting it is necessary to develop the methodological provision for accounting in accordance with the principles of sustainable development to ensure the reliability of the indices obtained; it is necessary to select the optimal list of indices that can meet the information needs of all users, in particular, investors, the state, auditors, society, creditors, consumers, employees, management personnel, academics, and the media. The main tasks and principles of compilation of the integrated reporting are presented. Orientation to the future, materiality, demand, integrity, reliability, completeness, periodicity, consistency, timeliness, interpretation, and comparability are suggested as the principles of integrated reporting. The issue of the necessity of conducting the external audit of the data verification of the integrity reporting is highlighted. The algorithm of profit distribution depending on the chosen strategy of enterprise development is proposed. When directing net profits for the development of production, the authors identify the following three strategies: insufficient upgrades, upgrades at the level of wear and the advanced renewal of non-current assets. It

  12. Fuzzy compromise: An effective way to solve hierarchical design problems

    Science.gov (United States)

    Allen, J. K.; Krishnamachari, R. S.; Masetta, J.; Pearce, D.; Rigby, D.; Mistree, F.

    1990-01-01

    In this paper, we present a method for modeling design problems using a compromise decision support problem (DSP) incorporating the principles embodied in fuzzy set theory. Specifically, the fuzzy compromise decision support problem is used to study hierarchical design problems. This approach has the advantage that although the system modeled has an element of uncertainty associated with it, the solution obtained is crisp and precise. The efficacy of incorporating fuzzy sets into the solution process is discussed in the context of results obtained for a portal frame.

  13. Integration of air quality-related planning processes : report

    International Nuclear Information System (INIS)

    2004-05-01

    Several communities in British Columbia have conducted air quality, greenhouse gas, or community energy management plans. This report explored the possibility of integrating 3 community-based air quality-related planning processes into a single process and evaluated the use of these 3 processes by local governments and First Nations in identifying and addressing air quality-related objectives, and determined to what extent they could be integrated to achieve planning objectives for air quality, greenhouse gas emissions, and energy supply and conservation. The lessons learned from 9 case studies in British Columbia were presented. The purpose of the case studies was to examine how communities handled emissions and energy related inventory and planning work, as well as their experiences with, or considerations for, an integrated process. The lessons were grouped under several key themes including organization and stakeholder involvement; messaging and focus; leadership/champions; and resources and capacity. The report also outlined a framework for an integrated planning process and provided recommendations regarding how an integrated or complementary process could be performed. A number of next steps were also offered for the provincial government to move the concept of an integrated process forward with the assistance of other partners. These included identifying the resources required to support communities engaging in an integrated process as well as discussing the series of options for provincial support with key stakeholders. refs., tabs., figs

  14. 45 CFR 1177.12 - Compromise, suspension and termination.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Compromise, suspension and termination. 1177.12 Section 1177.12 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON...) debts arising from GAO audit exceptions. ...

  15. 15 CFR 19.7 - When will Commerce entities compromise a Commerce debt?

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false When will Commerce entities compromise a Commerce debt? 19.7 Section 19.7 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce Debts § 19.7 When will Commerce entities compromise...

  16. Steam generator tubes integrity: In-service-inspection

    International Nuclear Information System (INIS)

    Comby, R.J.

    1997-01-01

    The author's approach to tube integrity is in terms of looking for flaws in tubes. The basis for this approach is that no simple rules can be fixed to adopt a universal inspection methodology because of various concepts related to experience, leak acceptance, leak before break approach, etc. Flaw specific management is probably the most reliable approach as a compromise between safety, availability and economic issues. In that case, NDE capabilities have to be in accordance with information required by structural integrity demonstration. The author discusses the types of probes which can be used to search for flaws in addition to the types of flaws which are being sought, with examples of specific analysis experiences. The author also discusses the issue of a reporting level as it relates to avoiding false calls, classifying faults, and allowing for automation in analysis

  17. The Social-Financial Responsible Reporting – The Key for Integrated Reporting

    OpenAIRE

    Iulia Jianu

    2012-01-01

    General purpose of financial statements is to satisfy the needs of users who are not in the position to require of the entity to prepare reports tailored to their particular information needs. Because the public is one of these users interested of social information and because the financial statement do not provide sufficient social information to satisfy these needs, the study demonstrate the need to integrate the responsible social reporting into financial reporting. In order to support th...

  18. Roles of Melatonin in Fetal Programming in Compromised Pregnancies

    Directory of Open Access Journals (Sweden)

    Yu-Chieh Chen

    2013-03-01

    Full Text Available Compromised pregnancies such as those associated with gestational diabetes mellitus, intrauterine growth retardation, preeclampsia, maternal undernutrition, and maternal stress may negatively affect fetal development. Such pregnancies may induce oxidative stress to the fetus and alter fetal development through the epigenetic process that may affect development at a later stage. Melatonin is an oxidant scavenger that reverses oxidative stress during the prenatal period. Moreover, the role of melatonin in epigenetic modifications in the field of developmental programming has been studied extensively. Here, we describe the physiological function of melatonin in pregnancy and discuss the roles of melatonin in fetal programming in compromised pregnancies, focusing on its involvement in redox and epigenetic mechanisms.

  19. Roles of Melatonin in Fetal Programming in Compromised Pregnancies

    Science.gov (United States)

    Chen, Yu-Chieh; Sheen, Jiunn-Ming; Tiao, Miao-Meng; Tain, You-Lin; Huang, Li-Tung

    2013-01-01

    Compromised pregnancies such as those associated with gestational diabetes mellitus, intrauterine growth retardation, preeclampsia, maternal undernutrition, and maternal stress may negatively affect fetal development. Such pregnancies may induce oxidative stress to the fetus and alter fetal development through the epigenetic process that may affect development at a later stage. Melatonin is an oxidant scavenger that reverses oxidative stress during the prenatal period. Moreover, the role of melatonin in epigenetic modifications in the field of developmental programming has been studied extensively. Here, we describe the physiological function of melatonin in pregnancy and discuss the roles of melatonin in fetal programming in compromised pregnancies, focusing on its involvement in redox and epigenetic mechanisms. PMID:23466884

  20. The impact of purchase quantity on the compromise effect: The balance heuristic

    Directory of Open Access Journals (Sweden)

    Yin-Hui Cheng

    2012-07-01

    Full Text Available Most prior research on the compromise effect has focused on single rather than multiple choices. This research investigates the potential effects of purchase quantity on the compromise effect. We propose that the share of the middle option in a trinary choice set decreases as the purchase quantity increases, because people tend to employ a balance heuristic to distribute their multiple choices among the available options to achieve a balanced state and to satisfy their variety-seeking tendency. Furthermore, we propose that the need for justification and an optimal stimulation level moderate the relationship between the number of purchase items and the compromise effect. These proposed hypotheses are supported by results from three experiments.

  1. 47 CFR 1.1915 - Exploration of compromise.

    Science.gov (United States)

    2010-10-01

    ... justification of the offer and addressing the bases for compromise at 31 CFR 902.2. Debtors will provide full.... Unless otherwise provided by law, when the principal balance of a debt, exclusive of interest, penalties... evaluate an offer, using the factors set forth in 31 CFR 902.2 and, as appropriate, refer the offer with...

  2. The GOTTHARD charge integrating readout detector: design and characterization

    International Nuclear Information System (INIS)

    Mozzanica, A; Bergamaschi, A; Dinapoli, R; Greiffenberg, D; Henrich, B; Johnson, I; Valeria, R; Schmitt, B; Xintian, S; Graafsma, H; Lohmann, M

    2012-01-01

    A charge integrating readout ASIC (Application Specific Integrated Circuit) for silicon strip sensors has been developed at PSI in collaboration with DESY. The goal of the project is to provide a charge integrating readout system able to cope with the pulsed beam of XFEL machines and at the same time to retain the high dynamic range and single photon resolution performances typical for photon counting systems. The ASIC, designed in IBM 130 nm CMOS technology, takes advantage of its three gain stages with automatic stage selection to achieve a dynamic range of 10000 12 keV photons and a noise better than 300 e.n.c.. The 4 analog outputs of the ASIC are optimized for speed, allowing frame rates higher than 1 MHz, without compromises on linearity and noise performances. This work presents the design features of the ASIC, and reports the characterization results of the chip itself.

  3. Business Excellence Assessment - from an Integrated Reporting Perspective

    Directory of Open Access Journals (Sweden)

    Valentin Burcă

    2016-01-01

    Full Text Available Economic globalization effects can easily be seen in various levels of decision process, affecting financial performance of each entity drastically. An essential variable on the decision process that is considered by managers, shareholders and stakeholders as well is the uncertainty of the economic environment that can be reduced through a flexible and up to date financial reporting model. In the light of the last evolutions of financial reporting model, standard-setters, researchers and practitioners as well, have realized the need for a change in the financial reporting regulation. Among listed entities, on which case financial transparency is essential on gaining investors trust, there has been drawn up a change in orientation concerning financial reporting model. As the focus falls now on value added potential, the new philosophy of integrated reporting has become of high interest for managers, shareholders and stakeholders as well. The paper is trying to describe this philosophy, from the perspective of business excellence models, widely spread globally nowadays. We will try to explain the integrated reporting utility on decision process by underlining the way this voluntary corporate reporting solution can give relevant information about value added potential of a reporting entity.

  4. INTEGRATION OF FINANCIAL AND NON-FINANCIAL REPORTS UNDER MANAGEMENT CONDITIONS

    Directory of Open Access Journals (Sweden)

    Mihail PRODANCIUK

    2013-02-01

    Full Text Available The paper presents the assessment of the development of integrated reports overseas and describes the stages of establishment of such a system. The form and structure of corporate reporting is developed, and is differentiated, reflecting the integrated information regarding aspects of financial and non-financial activity: statistical indicators, economical, financial and social, company strategy, future cash flows, the value of human capital, and the stability of the business model. Goals and objectives of corporate reports are determined, which consist in providing reliable information on all company activities in accordance with strategic objectives and management models. The structure of the integrated report takes into consideration the requirements of the management system, of the legislative bodies and other institutions, and is considered the basis for the development of branch reports models. Its structure will depend on the size of the legal-organizational form and the social value of the company in society. The author of the article suggests three approaches to achieving corporate reports in the section of social responsibility indicators; where each company chooses the form of reporting in accordance with the available categories that depend on the size and strategic policy. The suggested integrated reports are instrumental to the observance of the stable development doctrines and will become a tool that, in the near future, will ensure the company an effective interaction with financial markets and the stakeholders of market relations.

  5. Integration of financial and non-financial reports under management conditions

    Directory of Open Access Journals (Sweden)

    Prodanciuk Mihail

    2013-02-01

    Full Text Available The paper presents the assessment of the development of integrated reports overseas and describes the stages of establishment of such a system. The form and structure of corporate reporting is developed, and is differentiated, reflecting the integrated information regarding aspects of financial and non-financial activity: statistical indicators, economical, financial and social, company strategy, future cash flows, the value of human capital, and the stability of the business model. Goals and objectives of corporate reports are determined, which consist in providing reliable information on all company activities in accordance with strategic objectives and management models.The structure of the integrated report takes into consideration the requirements of the management system, of the legislative bodies and other institutions, and is considered the basis for the development of branch reports models. Its structure will depend on the size of the legal-organizational form and the social value of the company in society. The author of the article suggests three approaches to achieving corporate reports in the section of social responsibility indicators; where each company chooses the form of reporting in accordance with the available categories that depend on the size and strategic policy. The suggested integrated reports are instrumental to the observance of the stable development doctrines and will become a tool that, in the near future, will ensure the company an effective interaction with financial markets and the stakeholders of market relations.

  6. Methodological Bases for Describing Risks of the Enterprise Business Model in Integrated Reporting

    Directory of Open Access Journals (Sweden)

    Nesterenko Oksana O.

    2017-12-01

    Full Text Available The aim of the article is to substantiate the methodological bases for describing the business and accounting risks of an enterprise business model in integrated reporting for their timely detection and assessment, and develop methods for their leveling or minimizing and possible prevention. It is proposed to consider risks in the process of forming integrated reporting from two sides: first, risks that arise in the business model of an organization and should be disclosed in its integrated report; second, accounting risks of integrated reporting, which should be taken into account by members of the cross-sectoral working group and management personnel in the process of forming and promulgating integrated reporting. To develop an adequate accounting and analytical tool for disclosure of information about the risks of the business model and integrated reporting, their leveling or minimization, in the article a terminological analysis of the essence of entrepreneurial and accounting risks is carried out. The entrepreneurial risk is defined as an objective-subjective economic category that characterizes the probability of negative or positive consequences of economic-social-ecological activity within the framework of the business model of an enterprise under uncertainty. The accounting risk is suggested to be understood as the probability of unfavorable consequences as a result of organizational, methodological errors in the integrated accounting system, which present threat to the quality, accuracy and reliability of the reporting information on economic, social and environmental activities in integrated reporting as well as threat of inappropriate decision-making by stakeholders based on the integrated report. For the timely identification of business risks and maximum leveling of the influence of accounting risks on the process of formation and publication of integrated reporting, in the study the place of entrepreneurial and accounting risks in

  7. Simplified nonplanar wafer bonding for heterogeneous device integration

    Science.gov (United States)

    Geske, Jon; Bowers, John E.; Riley, Anton

    2004-07-01

    We demonstrate a simplified nonplanar wafer bonding technique for heterogeneous device integration. The improved technique can be used to laterally integrate dissimilar semiconductor device structures on a lattice-mismatched substrate. Using the technique, two different InP-based vertical-cavity surface-emitting laser active regions have been integrated onto GaAs without compromising the quality of the photoluminescence. Experimental and numerical simulation results are presented.

  8. The determinants of materiality disclosure in integrated corporate reporting

    OpenAIRE

    Chiara Mio; Marco Fasan

    2014-01-01

    The aim of this study is to test what drives the way in which companies disclose materiality in their Integrated Reports (IRs). Materiality is one of the main themes (and challenges) in the IR discourse, and it will probably play a central role in the actual success of the International Integrated Reporting Council framework. Companies managing to actually implement the materiality principle, will produce IRs which are concise and able to provide relevant information on the future performance...

  9. Is patient confidentiality compromised with the electronic health record?: a position paper.

    Science.gov (United States)

    Wallace, Ilse M

    2015-02-01

    In order for electronic health records to fulfill their expected benefits, protection of privacy of patient information is key. Lack of trust in confidentiality can lead to reluctance in disclosing all relevant information, which could have grave consequences. This position paper contemplates whether patient confidentiality is compromised by electronic health records. The position that confidentiality is compromised was supported by the four bioethical principles and argued that despite laws and various safeguards to protect patients' confidentiality, numerous data breaches have occurred. The position that confidentiality is not compromised was supported by virtue ethics and a utilitarian viewpoint and argued that safeguards keep information confidential and the public feels relatively safe with the electronic health record. The article concludes with an ethically superior position that confidentiality is compromised with the electronic health record. Although organizational and governmental ways of enhancing the confidentiality of patient information within the electronic health record facilitate confidentiality, the ultimate responsibility of maintaining confidentiality rests with the individual end-users and their ethical code of conduct. The American Nurses Association Code of Ethics for nurses calls for nurses to be watchful with data security in electronic communications.

  10. Saying more with less? Disclosure conciseness, completeness and balance in Integrated Reports

    NARCIS (Netherlands)

    G. Melloni (Gaia); A. Caglio (Ariela); P.M. Perego (Paolo)

    2017-01-01

    textabstractThe Integrated Reporting Framework of 2013 represents the latest international attempt to connect a firm's financial and sustainability (i.e., environmental, social and governance) performance in one company report. An Integrated Report (IR) should communicate "concisely" about how a

  11. Integrated Reporting as a Tool for Communicating with Stakeholders - Advantages and Disadvantages

    Science.gov (United States)

    Matuszyk, Iwona; Rymkiewicz, Bartosz

    2018-03-01

    Financial and non-financial reporting from the beginning of its existence is the primary source of communication between the company and a wide range of stakeholders. Over the decades it has adapted to the needs of rapidly changing business and social environment. Currently, the final link in the evolution of organizational reporting, such as integrated reporting, assumes integration and mutual connectivity to both financial and non-financial data. The main interest in the concept of integrated reporting comes from the value it contributes to the organization. Undoubtedly, the concept of integrated reporting is a milestone in the evolution of organizational reporting. It is however important to consider whether it adequately addresses the information needs of a wide range of stakeholders, and whether it is a universal tool for communication between the company and its stakeholders. The aim of the paper is to discuss the advantages and disadvantages of the concept of integrated reporting as a tool for communication with stakeholders and to further directions of its development. The article uses the research methods such as literature analysis, the content analysis of the corporate publications and comparative analysis.

  12. A lot of icing but little cake? Taking integrated reporting forward

    NARCIS (Netherlands)

    P.M. Perego (Paolo); S.P. Kennedy (Steve); G.M. Whiteman (Gail)

    2016-01-01

    textabstractIntegrated reporting has fast emerged as a new accounting practice to help firms understand how they create value and be able to effectively communicate this to external stakeholders. While insightful experiences from the early-adopters of integrated reporting start to accumulate, the

  13. Mitigating Reptile Road Mortality: Fence Failures Compromise Ecopassage Effectiveness

    Science.gov (United States)

    Baxter-Gilbert, James H.; Riley, Julia L.; Lesbarrères, David; Litzgus, Jacqueline D.

    2015-01-01

    Roadways pose serious threats to animal populations. The installation of roadway mitigation measures is becoming increasingly common, yet studies that rigorously evaluate the effectiveness of these conservation tools remain rare. A highway expansion project in Ontario, Canada included exclusion fencing and ecopassages as mitigation measures designed to offset detrimental effects to one of the most imperial groups of vertebrates, reptiles. Taking a multispecies approach, we used a Before-After-Control-Impact study design to compare reptile abundance on the highway before and after mitigation at an Impact site and a Control site from 1 May to 31 August in 2012 and 2013. During this time, radio telemetry, wildlife cameras, and an automated PIT-tag reading system were used to monitor reptile movements and use of ecopassages. Additionally, a willingness to utilize experiment was conducted to quantify turtle behavioral responses to ecopassages. We found no difference in abundance of turtles on the road between the un-mitigated and mitigated highways, and an increase in the percentage of both snakes and turtles detected dead on the road post-mitigation, suggesting that the fencing was not effective. Although ecopassages were used by reptiles, the number of crossings through ecopassages was lower than road-surface crossings. Furthermore, turtle willingness to use ecopassages was lower than that reported in previous arena studies, suggesting that effectiveness of ecopassages may be compromised when alternative crossing options are available (e.g., through holes in exclusion structures). Our rigorous evaluation of reptile roadway mitigation demonstrated that when exclusion structures fail, the effectiveness of population connectivity structures is compromised. Our project emphasizes the need to design mitigation measures with the biology and behavior of the target species in mind, to implement mitigation designs in a rigorous fashion, and quantitatively evaluate road

  14. Mitigating reptile road mortality: fence failures compromise ecopassage effectiveness.

    Directory of Open Access Journals (Sweden)

    James H Baxter-Gilbert

    Full Text Available Roadways pose serious threats to animal populations. The installation of roadway mitigation measures is becoming increasingly common, yet studies that rigorously evaluate the effectiveness of these conservation tools remain rare. A highway expansion project in Ontario, Canada included exclusion fencing and ecopassages as mitigation measures designed to offset detrimental effects to one of the most imperial groups of vertebrates, reptiles. Taking a multispecies approach, we used a Before-After-Control-Impact study design to compare reptile abundance on the highway before and after mitigation at an Impact site and a Control site from 1 May to 31 August in 2012 and 2013. During this time, radio telemetry, wildlife cameras, and an automated PIT-tag reading system were used to monitor reptile movements and use of ecopassages. Additionally, a willingness to utilize experiment was conducted to quantify turtle behavioral responses to ecopassages. We found no difference in abundance of turtles on the road between the un-mitigated and mitigated highways, and an increase in the percentage of both snakes and turtles detected dead on the road post-mitigation, suggesting that the fencing was not effective. Although ecopassages were used by reptiles, the number of crossings through ecopassages was lower than road-surface crossings. Furthermore, turtle willingness to use ecopassages was lower than that reported in previous arena studies, suggesting that effectiveness of ecopassages may be compromised when alternative crossing options are available (e.g., through holes in exclusion structures. Our rigorous evaluation of reptile roadway mitigation demonstrated that when exclusion structures fail, the effectiveness of population connectivity structures is compromised. Our project emphasizes the need to design mitigation measures with the biology and behavior of the target species in mind, to implement mitigation designs in a rigorous fashion, and quantitatively

  15. Development of Spreadsheet-Based Integrated Transaction Processing Systems and Financial Reporting Systems

    Science.gov (United States)

    Ariana, I. M.; Bagiada, I. M.

    2018-01-01

    Development of spreadsheet-based integrated transaction processing systems and financial reporting systems is intended to optimize the capabilities of spreadsheet in accounting data processing. The purpose of this study are: 1) to describe the spreadsheet-based integrated transaction processing systems and financial reporting systems; 2) to test its technical and operational feasibility. This study type is research and development. The main steps of study are: 1) needs analysis (need assessment); 2) developing spreadsheet-based integrated transaction processing systems and financial reporting systems; and 3) testing the feasibility of spreadsheet-based integrated transaction processing systems and financial reporting systems. The technical feasibility include the ability of hardware and operating systems to respond the application of accounting, simplicity and ease of use. Operational feasibility include the ability of users using accounting applications, the ability of accounting applications to produce information, and control applications of the accounting applications. The instrument used to assess the technical and operational feasibility of the systems is the expert perception questionnaire. The instrument uses 4 Likert scale, from 1 (strongly disagree) to 4 (strongly agree). Data were analyzed using percentage analysis by comparing the number of answers within one (1) item by the number of ideal answer within one (1) item. Spreadsheet-based integrated transaction processing systems and financial reporting systems integrate sales, purchases, and cash transaction processing systems to produce financial reports (statement of profit or loss and other comprehensive income, statement of changes in equity, statement of financial position, and statement of cash flows) and other reports. Spreadsheet-based integrated transaction processing systems and financial reporting systems is feasible from the technical aspects (87.50%) and operational aspects (84.17%).

  16. THE INTEGRATED REPORTING FRAMEWORK: BETWEEN CHALLENGE AND INNOVATION

    Directory of Open Access Journals (Sweden)

    Tudor OPRIȘOR

    2014-06-01

    Full Text Available Integrated Reporting has lately shown a great amount of interest for the business community, as it can offer a greater information value to all types of users. Thus, creating a proper framework for this type of reporting has been a top priority for the regulating bodies, with significant input from other interested parties. This paper aims to analyze the comments submitted to the Consultation Draft and to determine which questions gained more focus. Moreover, through this paper, we intend to reveal which types of respondents were more interested in discussing the Framework and to split them into several groups of interest. Finally, the main goal of the paper is to provide an overview on the discussions leading to the Framework’s final form and to determine how the comment letters can provide further perspectives on the implementation of Integrated Reporting.

  17. Integrated concurrent utilization quality review, Part one.

    Science.gov (United States)

    Caterinicchio, R P

    1987-01-01

    This article is the first of a two-part series which argues for the concurrent management of the appropriateness, necessity, and quality of patient care. Intensifying scrutiny by the credentialing groups, the PROs and all third-party payors underscores the vital need to implement cost-effective information systems which integrate the departmentalized functions of patient-physician profiling, DRG case-mix analyses, length of stay monitoring, pre-admission/admission and continued stay review, discharge planning, risk management, incident reporting and quality review. In the domain of physician performance regarding admitting and practice patterns, the ability to exercise concurrent utilization-quality review means early detection and prevention of events which would otherwise result in denials of payment and/or compromised patient care. Concurrent utilization-quality review must, by definition, be managerially invasive and focused; hence, it is integral to maintaining the integrity of the services and product lines offered by the provider. In fact, if PPO status is a marketing agenda, then the institutional objectives of cost-effectiveness, productivity, value, and competitiveness can only be achieved through concurrent utilization-quality review.

  18. Integer goal programming approach for finding a compromise ...

    African Journals Online (AJOL)

    In second model the cost and time spent on repairing the components are considered as two different objectives. Selective maintenance operation is used to select the repairable components and a multi-objective goal programming algorithm is proposed to obtain compromise selection of repairable components for the two ...

  19. Power, Avionics and Software - Phase 1.0:. [Subsystem Integration Test Report

    Science.gov (United States)

    Ivancic, William D.; Sands, Obed S.; Bakula, Casey J.; Oldham, Daniel R.; Wright, Ted; Bradish, Martin A.; Klebau, Joseph M.

    2014-01-01

    This report describes Power, Avionics and Software (PAS) 1.0 subsystem integration testing and test results that occurred in August and September of 2013. This report covers the capabilities of each PAS assembly to meet integration test objectives for non-safety critical, non-flight, non-human-rated hardware and software development. This test report is the outcome of the first integration of the PAS subsystem and is meant to provide data for subsequent designs, development and testing of the future PAS subsystems. The two main objectives were to assess the ability of the PAS assemblies to exchange messages and to perform audio testing of both inbound and outbound channels. This report describes each test performed, defines the test, the data, and provides conclusions and recommendations.

  20. Robust Public Key Cryptography — A New Cryptosystem Surviving Private Key Compromise

    Science.gov (United States)

    Shaik, Cheman

    A weakness of the present-day public key cryptosystems is that these cryptosystems do not survive private-key compromise attacks resulting from an internal breach of trust. In a competitive business environment, private key compromise is a common incident that voids the strength of public key cryptosystems such as RSA and ECC. Bribing corporate employees to disclose their secret keys and inadvertently disclosing secret information are among a plethora of practical attacks that occur at the implementation level. Once a breach of trust takes place and subsequently the private key is revealed, any public key cryptosystem fails to secure electronic data in Internet communications. The revealed key may be used by an attacker to decipher the intercepted data at an intermediary router. This weakness of public key cryptography calls for an additional security measure that enables encryptions to survive private key compromise attacks.

  1. The Determination of Essentiality as a Leading Principle of the Formation of Integrated Reporting

    Directory of Open Access Journals (Sweden)

    Makarenko Vita Yu.

    2018-03-01

    Full Text Available The definition of essentiality as the leading principle of formation of integrated reporting is considered. The normative basis of essentiality in the context of integrated reporting is the International standard for integrated reporting. The principle of essentiality is that the integrated report should disclose information on issues that have a significant impact on an assessment of the organization’s ability to generate value in the short, medium, and long term periods. Essential for an integrated report is information that is capable of making changes to the organization’s value creation procedure. The definition of essentiality indicates that the essential information is the one that can change the order of assessment of any particular event. Therefore, insignificant for the integrated report is the information that cannot and does not bring such changes. The lack of a clear methodology for determining the essentiality, on the one hand, facilitates application of the principle of essentiality in specific conditions, and on the other — reduces the comparability of indicators of integrated reporting.

  2. Identifying genetic relatives without compromising privacy.

    Science.gov (United States)

    He, Dan; Furlotte, Nicholas A; Hormozdiari, Farhad; Joo, Jong Wha J; Wadia, Akshay; Ostrovsky, Rafail; Sahai, Amit; Eskin, Eleazar

    2014-04-01

    The development of high-throughput genomic technologies has impacted many areas of genetic research. While many applications of these technologies focus on the discovery of genes involved in disease from population samples, applications of genomic technologies to an individual's genome or personal genomics have recently gained much interest. One such application is the identification of relatives from genetic data. In this application, genetic information from a set of individuals is collected in a database, and each pair of individuals is compared in order to identify genetic relatives. An inherent issue that arises in the identification of relatives is privacy. In this article, we propose a method for identifying genetic relatives without compromising privacy by taking advantage of novel cryptographic techniques customized for secure and private comparison of genetic information. We demonstrate the utility of these techniques by allowing a pair of individuals to discover whether or not they are related without compromising their genetic information or revealing it to a third party. The idea is that individuals only share enough special-purpose cryptographically protected information with each other to identify whether or not they are relatives, but not enough to expose any information about their genomes. We show in HapMap and 1000 Genomes data that our method can recover first- and second-order genetic relationships and, through simulations, show that our method can identify relationships as distant as third cousins while preserving privacy.

  3. Analysis of Waste Isolation Pilot Plant Samples: Integrated Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Britt, Phillip F [ORNL

    2015-03-01

    Analysis of Waste Isolation Pilot Plant Samples: Integrated Summary Report. Summaries of conclusions, analytical processes, and analytical results. Analysis of samples taken from the Waste Isolation Pilot Plant (WIPP) near Carlsbad, New Mexico in support of the WIPP Technical Assessment Team (TAT) activities to determine to the extent feasible the mechanisms and chemical reactions that may have resulted in the breach of at least one waste drum and release of waste material in WIPP Panel 7 Room 7 on February 14, 2014. This report integrates and summarizes the results contained in three separate reports, described below, and draws conclusions based on those results. Chemical and Radiochemical Analyses of WIPP Samples R-15 C5 SWB and R16 C-4 Lip; PNNL-24003, Pacific Northwest National Laboratory, December 2014 Analysis of Waste Isolation Pilot Plant (WIPP) Underground and MgO Samples by the Savannah River National Laboratory (SRNL); SRNL-STI-2014-00617; Savannah River National Laboratory, December 2014 Report for WIPP UG Sample #3, R15C5 (9/3/14); LLNL-TR-667015; Lawrence Livermore National Laboratory, January 2015 This report is also contained in the Waste Isolation Pilot Plant Technical Assessment Team Report; SRNL-RP-2015-01198; Savannah River National Laboratory, March 17, 2015, as Appendix C: Analysis Integrated Summary Report.

  4. Health and Well-Being Metrics in Business: The Value of Integrated Reporting.

    Science.gov (United States)

    Pronk, Nicolaas P; Malan, Daniel; Christie, Gillian; Hajat, Cother; Yach, Derek

    2018-01-01

    Health and well-being (HWB) are material to sustainable business performance. Yet, corporate reporting largely lacks the intentional inclusion of HWB metrics. This brief report presents an argument for inclusion of HWB metrics into existing standards for corporate reporting. A Core Scorecard and a Comprehensive Scorecard, designed by a team of subject matter experts, based on available evidence of effectiveness, and organized around the categories of Governance, Management, and Evidence of Success, may be integrated into corporate reporting efforts. Pursuit of corporate integrated reporting requires corporate governance and ethical leadership and values that ultimately align with environmental, social, and economic performance. Agreement on metrics that intentionally include HWB may allow for integrated reporting that has the potential to yield significant value for business and society alike.

  5. Integrated system checkout report

    International Nuclear Information System (INIS)

    1991-01-01

    The planning and preparation phase of the Integrated Systems Checkout Program (ISCP) was conducted from October 1989 to July 1991. A copy of the ISCP, DOE-WIPP 90--002, is included in this report as an appendix. The final phase of the Checkout was conducted from July 10, 1991, to July 23, 1991. This phase exercised all the procedures and equipment required to receive, emplace, and retrieve contact handled transuranium (CH TRU) waste filled dry bins. In addition, abnormal events were introduced to simulate various equipment failures, loose surface radioactive contamination events, and personnel injury. This report provides a detailed summary of each days activities during this period. Qualification of personnel to safely conduct the tasks identified in the procedures and the abnormal events were verified by observers familiar with the Bin-Scale CH TRU Waste Test requirements. These observers were members of the staffs of Westinghouse WID Engineering, QA, Training, Health Physics, Safety, and SNL. Observers representing a number of DOE departments, the state of new Mexico, and the Defense Nuclear Facilities Safety Board observed those Checkout activities conducted during the period from July 17, 1991, to July 23, 1991. Observer comments described in this report are those obtained from the staff member observers. 1 figs., 1 tab

  6. State-of-the-Art Report on Ethics of Research Integrity

    International Nuclear Information System (INIS)

    Kwon, Hyuk; Hahn, K. W.; Nam, Y. M.; You, B. H.; Min, B. J.

    2006-04-01

    The report briefly considers the generous ethical issues such as the background of philosophy, the issues of research ethics, the research integrity, the role of citation, the program and the code of research ethics. The report introduces the background of philosophy of science and elements of research ethics. It also considers the precedents of misconduct in research ethics and the ingredients to preserve the research integrity. Especially, the citation with obscure boundary between proper citation and plagiarism is carefully explored through several examples. Finally, the domestic ethics conditions are investigated on the research integrity and educational program on the responsible conduct of research. To compare the domestic situation, the educational program and the system of research integrity in EU and USA are deeply searched in Ch. 6 and Appendix III and V. To develop an educational program of research ethics and integrity, Nuclear Training Centre(NTC) collects and arranges the material and resource for research ethics

  7. State-of-the-Art Report on Ethics of Research Integrity

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Hyuk; Hahn, K. W.; Nam, Y. M.; You, B. H.; Min, B. J

    2006-04-15

    The report briefly considers the generous ethical issues such as the background of philosophy, the issues of research ethics, the research integrity, the role of citation, the program and the code of research ethics. The report introduces the background of philosophy of science and elements of research ethics. It also considers the precedents of misconduct in research ethics and the ingredients to preserve the research integrity. Especially, the citation with obscure boundary between proper citation and plagiarism is carefully explored through several examples. Finally, the domestic ethics conditions are investigated on the research integrity and educational program on the responsible conduct of research. To compare the domestic situation, the educational program and the system of research integrity in EU and USA are deeply searched in Ch. 6 and Appendix III and V. To develop an educational program of research ethics and integrity, Nuclear Training Centre(NTC) collects and arranges the material and resource for research ethics.

  8. Salivary changes in medically compromised patients: A clinical and biochemical study

    Directory of Open Access Journals (Sweden)

    Yehoshuva R Tummuru

    2017-01-01

    Full Text Available Introduction: Medically compromised patients require special attention when dental procedures are performed on them. These individuals may require modified or slightly altered techniques. Aims and Objectives: The present study was taken up with two main objectives. The first one being examining and recording various oral manifestations in medically compromised patients, and the second objective was to collect samples of saliva from such patients and to analyze and establish any salivary changes in such medically compromised patients. Materials and Methods: A total of 100 patients were selected for the study. These patients were divided into four groups of 25 patients each: diabetes mellitus group, chronic renal failure group, liver cirrhosis group and control group. All the selected patients were subjected to a detailed general and intra oral examinations and the relevant data was recorded on a specially designed proforma; salivary analysis was done to know the flow rate, pH, total salivary proteins, sodium, potassium, and LDH levels. Results: From the findings, it can be inferred that salivary changes namely changes in salivary pH, salivary flow rates, salivary sodium, salivary potassium, salivary total proteins, and salivary lactate dehydrogenase are significant in medically compromised patients namely uncontrolled diabetes mellitus, chronic renal failure, cirrhosis of liver compared to the control group. Conclusion: pH of saliva was elevated in chronic renal failure patients. Salivary flow rates and sodium were decreased in diabetes mellitus, chronic renal failure, and cirrhosis of liver patients. There was a significant elevation of salivary potassium in chronic renal failure patients. LDH elevation was significant in uncontrolled diabetes mellitus.

  9. Integrative Report on a culture-sensitive quality & curriculum framework

    NARCIS (Netherlands)

    Sylva, Kathy; Ereky-Stevens, Katharina; Pastori, Giulia; Slot, P.L.; Lerkkanen, Marja-Kristiina

    This report draws together research findings that support a comprehensive culture-sensitive European curriculum and quality assessment framework that can inform practice, teacher education and policy. The aim of this integrative report is to inform the development of a comprehensive,

  10. Integration of torrefaction in CHP plants – A case study

    International Nuclear Information System (INIS)

    Starfelt, Fredrik; Tomas Aparicio, Elena; Li, Hailong; Dotzauer, Erik

    2015-01-01

    Highlights: • We model the integration of a torrefaction reactor in a CHP plant. • Techno-economic analysis for the system is performed. • Flue gas integration of torrefaction show better performance. • Heat or electricity production is not compromised in the proposed system. - Abstract: Torrefied biomass shows characteristics that resemble those of coal. Therefore, torrefied biomass can be co-combusted with coal in existing coal mills and burners. This paper presents simulation results of a case study where a torrefaction reactor was integrated in an existing combined heat and power plant and sized to replace 25%, 50%, 75% or 100% of the fossil coal in one of the boilers. The simulations show that a torrefaction reactor can be integrated with existing plants without compromising heat or electricity production. Economic and sensitivity analysis show that the additional cost for integrating a torrefaction reactor is low which means that with an emission allowance cost of 37 €/ton CO 2 , the proposed integrated system can be profitable and use 100% renewable fuels. The development of subsidies will affect the process economy. The determinant parameters are electricity and fuel prices

  11. Enhancing water and fertilizer saving without compromising rice yield through integrated crop management

    NARCIS (Netherlands)

    Wardana, I.P.; Gani, A.; Abdulrachmann, S.; Bindraban, P.S.; Keulen, van H.

    2010-01-01

    Water and fertilizer scarcity amid the increasing need of rice production challenges today’s agriculture. Integrated crop management (ICM) is a combination of water, crop, and nutrient management that optimizes the synergistic interaction of these components aiming at improving resource use

  12. 26 CFR 301.6331-3 - Restrictions on levy while offers to compromise are pending.

    Science.gov (United States)

    2010-04-01

    ... are pending. 301.6331-3 Section 301.6331-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF... for Collection of Taxes § 301.6331-3 Restrictions on levy while offers to compromise are pending. Cross-reference. For provisions relating to the making of levies while an offer to compromise is pending...

  13. Integrated sequence analysis. Final report

    International Nuclear Information System (INIS)

    Andersson, K.; Pyy, P.

    1998-02-01

    The NKS/RAK subprojet 3 'integrated sequence analysis' (ISA) was formulated with the overall objective to develop and to test integrated methodologies in order to evaluate event sequences with significant human action contribution. The term 'methodology' denotes not only technical tools but also methods for integration of different scientific disciplines. In this report, we first discuss the background of ISA and the surveys made to map methods in different application fields, such as man machine system simulation software, human reliability analysis (HRA) and expert judgement. Specific event sequences were, after the surveys, selected for application and testing of a number of ISA methods. The event sequences discussed in the report were cold overpressure of BWR, shutdown LOCA of BWR, steam generator tube rupture of a PWR and BWR disturbed signal view in the control room after an external event. Different teams analysed these sequences by using different ISA and HRA methods. Two kinds of results were obtained from the ISA project: sequence specific and more general findings. The sequence specific results are discussed together with each sequence description. The general lessons are discussed under a separate chapter by using comparisons of different case studies. These lessons include areas ranging from plant safety management (design, procedures, instrumentation, operations, maintenance and safety practices) to methodological findings (ISA methodology, PSA,HRA, physical analyses, behavioural analyses and uncertainty assessment). Finally follows a discussion about the project and conclusions are presented. An interdisciplinary study of complex phenomena is a natural way to produce valuable and innovative results. This project came up with structured ways to perform ISA and managed to apply the in practice. The project also highlighted some areas where more work is needed. In the HRA work, development is required for the use of simulators and expert judgement as

  14. Integrated sequence analysis. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, K.; Pyy, P

    1998-02-01

    The NKS/RAK subprojet 3 `integrated sequence analysis` (ISA) was formulated with the overall objective to develop and to test integrated methodologies in order to evaluate event sequences with significant human action contribution. The term `methodology` denotes not only technical tools but also methods for integration of different scientific disciplines. In this report, we first discuss the background of ISA and the surveys made to map methods in different application fields, such as man machine system simulation software, human reliability analysis (HRA) and expert judgement. Specific event sequences were, after the surveys, selected for application and testing of a number of ISA methods. The event sequences discussed in the report were cold overpressure of BWR, shutdown LOCA of BWR, steam generator tube rupture of a PWR and BWR disturbed signal view in the control room after an external event. Different teams analysed these sequences by using different ISA and HRA methods. Two kinds of results were obtained from the ISA project: sequence specific and more general findings. The sequence specific results are discussed together with each sequence description. The general lessons are discussed under a separate chapter by using comparisons of different case studies. These lessons include areas ranging from plant safety management (design, procedures, instrumentation, operations, maintenance and safety practices) to methodological findings (ISA methodology, PSA,HRA, physical analyses, behavioural analyses and uncertainty assessment). Finally follows a discussion about the project and conclusions are presented. An interdisciplinary study of complex phenomena is a natural way to produce valuable and innovative results. This project came up with structured ways to perform ISA and managed to apply the in practice. The project also highlighted some areas where more work is needed. In the HRA work, development is required for the use of simulators and expert judgement as

  15. Sustainable Development Compromise[d] in the Planning of Metro Vancouver’s Agricultural Lands—the Jackson Farm Case

    Directory of Open Access Journals (Sweden)

    Meg Holden

    2013-11-01

    Full Text Available This research provides analysis of the case of the Jackson Farm development application, embedded within the particular dynamics of the municipal, regional, and provincial sustainability land use policy culture of the Metro Vancouver region, in Canada. Within a culture of appreciation of the increasing need for sustainability in land use policy, including the protection of agricultural lands at the provincial level through the Agricultural Land Reserve (ALR, to urban intensification and protection of the green zone at the regional scale, lies a political conflict that comes into focus in individual land use decisions, within municipalities struggling for autonomy. This case is neither driven strictly by “the politics of the highest bidder” nor by policy failure; the case of the Jackson Farm is instead a case of the challenges of implementing inter-governmental coordination and collaborative governance in a context of both significant sustainability policy and urban growth. The process can be seen to follow an ecological modernization agenda, seeking “win–win” alternatives rather than recognizing that typical compromises, over time, may tip the direction of development away from sustainability policy goals. Understanding the twists, turns, and eventual compromise reached in the case of the Jackson Farm brings to light the implications of the shift in the regional planning culture which may necessitate a less flexible, more structured prioritization of competing goals within plans and policies in order to meet sustainability goals. We highlight this, and present an alternative implementation process within the existing policy regime with potential to aid the specific goal of agricultural land protection.

  16. [Tuberculosis in compromised hosts].

    Science.gov (United States)

    2003-11-01

    Recent development of tuberculosis in Japan tends to converge on a specific high risk group. The proportion of tuberculosis developing particularly from the compromised hosts in the high risk group is especially high. At this symposium, therefore, we took up diabetes mellitus, gastrectomy, dialysis, AIDS and the elderly for discussion. Many new findings and useful reports for practical medical treatment are submitted; why these compromised hosts are predisposed to tuberculosis, tuberculosis diagnostic and remedial notes of those compromised hosts etc. It is an important question for the future to study how to prevent tuberculosis from these compromised hosts. 1. Tuberculosis in diabetes mellitus: aggravation and its immunological mechanism: Kazuyoshi KAWAKAMI (Department of Internal Medicine, Division of Infectious Diseases, Graduate School and Faculty of Medicine, University of the Ryukyus). It has been well documented that diabetes mellitus (DM) is a major aggravating factor in tuberculosis. The onset of this disease is more frequent in DM patients than in individuals with any underlying diseases. However, the precise mechanism of this finding remains to be fully understood. Earlier studies reported that the migration, phagocytosis and bactericidal activity of neutrophils are all impaired in DM patients, which is related to their reduced host defense to infection with extracellular bacteria, such as S. aureus and E. colli. Host defense to mycobacterial infection is largely mediated by cellular immunity, and Th1-related cytokines, such as IFN-gamma and IL-12, play a central role in this response. It is reported that serum level of these cytokines and their production by peripheral blood mononuclear cells (PBMC) are reduced in tuberculosis patients with DM, and this is supposed to be involved in the high incidence of tuberculosis in DM. Our study observed similar findings and furthermore indicated that IFN-gamma and IL-12 production by BCG-stimulated PBMC was lower

  17. Integrity assessment report of tanks TK-101 and TK-102

    Energy Technology Data Exchange (ETDEWEB)

    MCSHANE, D.S.

    1999-08-25

    This Integrity Assessment Report (IAR) is prepared by Fluor Daniel Northwest (FDNW) for Waste Management Federal Services of Hanford, Inc., (WMH), the operations contractor; Fluor Daniel Hanford (FDH), the Hanford Site Manager; and the U. S. Department of Energy (DOE), the system owner. This IAR addresses the evaluation of Tanks 101 and 102 and other existing components located in the 219-S Waste Handling Facility. This report will be included in the Part B Permit for the 2226 Laboratory and is a portion of the integrity assessment of the overall 222-5 Laboratory radioactive liquid waste disposal system. This IAR is prepared in accordance with WAC 173-303, Dangerous Waste Regulations; Section 640(2), ''Assessment of Existing Tank Systems Integrity .''

  18. Integrity assessment report of tanks TK-101 and TK-102

    International Nuclear Information System (INIS)

    MCSHANE, D.S.

    1999-01-01

    This Integrity Assessment Report (IAR) is prepared by Fluor Daniel Northwest (FDNW) for Waste Management Federal Services of Hanford, Inc., (WMH), the operations contractor; Fluor Daniel Hanford (FDH), the Hanford Site Manager; and the U. S. Department of Energy (DOE), the system owner. This IAR addresses the evaluation of Tanks 101 and 102 and other existing components located in the 219-S Waste Handling Facility. This report will be included in the Part B Permit for the 2226 Laboratory and is a portion of the integrity assessment of the overall 222-5 Laboratory radioactive liquid waste disposal system. This IAR is prepared in accordance with WAC 173-303, Dangerous Waste Regulations; Section 640(2), ''Assessment of Existing Tank Systems Integrity .''

  19. Sterile diets for the immuno-compromised: Is there a need?

    Science.gov (United States)

    Butterweck, Joseph S.

    1995-02-01

    There is a general misunderstanding in the radiation processing industry about the use of sterile diets in the medical profession. Sterile diets are used on a limited basis in hospitals that specialize in cancer treatment and organ transplants. These patients are severely immuno-compromised. There are many other patients that are immuno-compromised that do not require sterile diets. These patients may require a diet that is pathogen-free and are aslo "low-microbial diets". Nosocomial infections have become a major issue in US hospitals. The "infection control committee" is the focus group responsible to assure nosocomial infections incidence are below the hospital goals. Application of ionizing radiation to sterilize diets has not been chosen because the product is not available at a reasonable total cost. This paper will discuss the hospitals views.

  20. Methamphetamine compromises gap junctional communication in astrocytes and neurons.

    Science.gov (United States)

    Castellano, Paul; Nwagbo, Chisom; Martinez, Luis R; Eugenin, Eliseo A

    2016-05-01

    Methamphetamine (meth) is a central nervous system (CNS) stimulant that results in psychological and physical dependency. The long-term effects of meth within the CNS include neuronal plasticity changes, blood-brain barrier compromise, inflammation, electrical dysfunction, neuronal/glial toxicity, and an increased risk to infectious diseases including HIV. Most of the reported meth effects in the CNS are related to dysregulation of chemical synapses by altering the release and uptake of neurotransmitters, especially dopamine, norepinephrine, and epinephrine. However, little is known about the effects of meth on connexin (Cx) containing channels, such as gap junctions (GJ) and hemichannels (HC). We examined the effects of meth on Cx expression, function, and its role in NeuroAIDS. We found that meth altered Cx expression and localization, decreased GJ communication between neurons and astrocytes, and induced the opening of Cx43/Cx36 HC. Furthermore, we found that these changes in GJ and HC induced by meth treatment were mediated by activation of dopamine receptors, suggesting that dysregulation of dopamine signaling induced by meth is essential for GJ and HC compromise. Meth-induced changes in GJ and HC contributed to amplified CNS toxicity by dysregulating glutamate metabolism and increasing the susceptibility of neurons and astrocytes to bystander apoptosis induced by HIV. Together, our results indicate that connexin containing channels, GJ and HC, are essential in the pathogenesis of meth and increase the sensitivity of the CNS to HIV CNS disease. Methamphetamine (meth) is an extremely addictive central nervous system stimulant. Meth reduced gap junctional (GJ) communication by inducing internalization of connexin-43 (Cx43) in astrocytes and reducing expression of Cx36 in neurons by a mechanism involving activation of dopamine receptors (see cartoon). Meth-induced changes in Cx containing channels increased extracellular levels of glutamate and resulted in higher

  1. Video-Assisted versus Open Lobectomy in Patients with Compromised Lung Function: A Literature Review and Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Ruoyu Zhang

    Full Text Available It has been suggested that video-assisted (VATS lobectomy is safer than open lobectomy in patients with compromised lung function, but data regarding this are limited. We assessed acute outcomes of VATS compared to open lobectomy in these high-risk patients using a systematic literature review and meta-analysis of data.The databases PubMed and Scopus were searched for studies published between 2000 and 2013 that reported mortality and morbidity of VATS in high-risk lung cancer patients defined as having compromised pulmonary or cardiopulmonary function. Study selection, data collection and critical assessment of the included studies were performed according to the recommendations of the Cochrane Collaboration.Three case-control studies and three case series that included 330 VATS and 257 open patients were identified for inclusion. Operative mortality, overall morbidity and pulmonary morbidity were 2.5%, 39.3%, 26.2% in VATS patients and 7.8%, 57.5%, 45.5% in open lobectomy group, respectively. VATS lobectomy patients experienced significantly lower pulmonary morbidity (RR = 0.45; 95% CI, 0.30 to 0.67; p = 0.0001, somewhat reduced operative mortality (RR = 0.51; 95% CI, 0.24 to 1.06; p = 0.07, but no significant difference in overall morbidity (RR = 0.68; 95% CI, 0.41 to 1.14; p = 0.14.The existing data suggest that VATS lobectomy is associated with lower risk for pulmonary morbidity compared with open lobectomy in lung cancer patients with compromised lung function.

  2. Business Case for Integrated Reporting in the Nigerian Oil and Gas Sector

    Directory of Open Access Journals (Sweden)

    Tajudeen J. AYOOLA

    2013-03-01

    were sourced from the annual reports and stand-alone sustainability reports of the six multinational companies operating in the Nigerian oil and gas sector. The results found that efforts to address environmental, social and governance reporting (ESG were adhoc, short term and unrelated to the core activities of the corporations and as such were not integrated into their business strategies and model. Information on ESG was also duplicated over many medium in a haphazard and distorted form. The study therefore concluded that the introduction of integrated reporting will streamline performance reporting that is in line with international best practice in the sector.

  3. Auditing Litigation and Claims: Conflicts and the Compromise of Privilege

    Directory of Open Access Journals (Sweden)

    Harleen Kaur

    2013-12-01

    Full Text Available Auditing standards require an auditor to make various enquiries about liabilities in general this may entail consideration of potential litigations and claims that the audited entity may be facing. To perform this part of audit, the auditors will generally seek representation letters from lawyers of the company detailing an estimate prepared by management, confirmed by their lawyers through a representation letter, and then sent directly to the auditors. This paper reviews the implications for the auditing profession of a case that involved auditors seeking such representation letters. The case involves litigation between theWestpac Banking Corporation and 789TEN Pty Ltd. While theWestpac case confirmed the legal position of the auditor in their task of collecting evidence in order to form an opinion in Australia, it highlights a significant anomaly under the law and should place the issue of solicitor’s representation letters as audit evidence firmly on the agenda of policymakers. This issue of the compromise of legal privilege during the conduct of an audit is also not confined to Australia: other common law jurisdictions, such as the UK and the US, have also sought to clarify the position of auditors when issues of the integrity of legal privacy privilege arise.

  4. TMI-2 Vessel Investigation Project integration report

    International Nuclear Information System (INIS)

    Wolf, J.R.; Rempe, J.L.; Stickler, L.A.; Korth, G.E.; Diercks, D.R.; Neimark, L.A.; Akers, D.W.; Schuetz, B.K.; Shearer, T.L.; Chavez, S.A.; Thinnes, G.L.; Witt, R.J.; Corradini, M.L.; Kos, J.A.

    1994-03-01

    The Three Mile Island Unit 2 (TMI-2) Vessel Investigation Project (VIP) was an international effort that was sponsored by the Nuclear Energy Agency of the Organization for Economic Cooperation and Development. The primary objectives of the VIP were to extract and examine samples from the lower head and to evaluate the potential modes of failure and the margin of structural integrity that remained in the TMI-2 reactor vessel during the accident. This report presents a summary of the major findings and conclusions that were developed from research during the VIP. Results from the various elements of the project are integrated to form a cohesive understanding of the vessel's condition after the accident

  5. TMI-2 Vessel Investigation Project integration report

    Energy Technology Data Exchange (ETDEWEB)

    Wolf, J. R.; Rempe, J. L.; Stickler, L. A.; Korth, G. E.; Diercks, D. R.; Neimark, L. A.; Akers, D W; Schuetz, B. K.; Shearer, T L; Chavez, S. A.; Thinnes, G. L.; Witt, R. J.; Corradini, M L; Kos, J. A. [EG and G Idaho, Inc., Idaho Falls, ID (United States)

    1994-03-01

    The Three Mile Island Unit 2 (TMI-2) Vessel Investigation Project (VIP) was an international effort that was sponsored by the Nuclear Energy Agency of the Organization for Economic Cooperation and Development. The primary objectives of the VIP were to extract and examine samples from the lower head and to evaluate the potential modes of failure and the margin of structural integrity that remained in the TMI-2 reactor vessel during the accident. This report presents a summary of the major findings and conclusions that were developed from research during the VIP. Results from the various elements of the project are integrated to form a cohesive understanding of the vessel`s condition after the accident.

  6. Report on Integrating Activities and Models for Collaboration

    DEFF Research Database (Denmark)

    Buus, Lillian; Dirckinck-Holmfeld, Lone; Ryberg, Thomas

    This report is the deliverable for work package (WP) 28.3 “Integrated network and activities for the exchange of and collaboration between Master students, PhD students and professors” of the European Research Team (ERT) on Conditions for Productive Networked Learning Environments. The objective...... of WP28.3 is to build up an integrated network and activities for the exchange and collaboration between Master students, professional masters, PhD students and professors and to establish a virtual community around the research area of conditions for productive learning in networked learning...

  7. A Compromise Programming Model for Highway Maintenance Resources Allocation Problem

    Directory of Open Access Journals (Sweden)

    Hui Xiong

    2012-01-01

    Full Text Available This paper formulates a bilevel compromise programming model for allocating resources between pavement and bridge deck maintenances. The first level of the model aims to solve the resource allocation problems for pavement management and bridge deck maintenance, without considering resource sharing between them. At the second level, the model uses the results from the first step as an input and generates the final solution to the resource-sharing problem. To solve the model, the paper applies genetic algorithms to search for the optimal solution. We use a combination of two digits to represent different maintenance types. Results of numerical examples show that the conditions of both pavements and bridge decks are improved significantly by applying compromise programming, rather than conventional methods. Resources are also utilized more efficiently when the proposed method is applied.

  8. Metrics for Assessment of Smart Grid Data Integrity Attacks

    Energy Technology Data Exchange (ETDEWEB)

    Annarita Giani; Miles McQueen; Russell Bent; Kameshwar Poolla; Mark Hinrichs

    2012-07-01

    There is an emerging consensus that the nation’s electricity grid is vulnerable to cyber attacks. This vulnerability arises from the increasing reliance on using remote measurements, transmitting them over legacy data networks to system operators who make critical decisions based on available data. Data integrity attacks are a class of cyber attacks that involve a compromise of information that is processed by the grid operator. This information can include meter readings of injected power at remote generators, power flows on transmission lines, and relay states. These data integrity attacks have consequences only when the system operator responds to compromised data by redispatching generation under normal or contingency protocols. These consequences include (a) financial losses from sub-optimal economic dispatch to service loads, (b) robustness/resiliency losses from placing the grid at operating points that are at greater risk from contingencies, and (c) systemic losses resulting from cascading failures induced by poor operational choices. This paper is focused on understanding the connections between grid operational procedures and cyber attacks. We first offer two examples to illustrate how data integrity attacks can cause economic and physical damage by misleading operators into taking inappropriate decisions. We then focus on unobservable data integrity attacks involving power meter data. These are coordinated attacks where the compromised data are consistent with the physics of power flow, and are therefore passed by any bad data detection algorithm. We develop metrics to assess the economic impact of these attacks under re-dispatch decisions using optimal power flow methods. These metrics can be use to prioritize the adoption of appropriate countermeasures including PMU placement, encryption, hardware upgrades, and advance attack detection algorithms.

  9. Environmetal report 2016. Impulses for an integrative environmental policy

    International Nuclear Information System (INIS)

    2016-01-01

    The ecological challenges in the EU and Germany are so large that they can no longer simply be addressed using the remedial and even the technically-oriented, preventive environmental protection measures of the past. In relation to climate protection and many other fields, impacts on natural ecosystems must be substantially reduced in order to ensure that key ecosystem services remain functional. Yet, environmental policies continue to encounter stiff opposition, which is targeted at supposedly unnecessary regulatory burdens and restrictions. Opponents of environmental protection claim that environmental policies jeopardize the competitiveness of the German industrial and agricultural sectors by imposing unduly high costs. Or they bring up social issues, such as the current housing crisis or energy poverty, as arguments against an effective environmental policy. Such arguments call for nuanced assessments - and in some cases should be clearly rejected. Defusing such conflicts calls for approaches that promote compromise and that appeal to the general public. In the Environmental Report 2016, the German Advisory Council on the Environment (SRU) sets itself the task of addressing this challenge, by focusing on six key topics. What these topics all have in common is that they exhibit tensions between environmental and economic or social policy goals. The Environmental Report aims to stimulate ideas about environmental oriented reforms and approaches to managing these issues which cut across policy fields.

  10. Whatever It Takes: Health Compromising Behaviors in Female Athletes

    Science.gov (United States)

    Waldron, Jennifer J.; Krane, Vikki

    2005-01-01

    The power and performance model of sport stresses a sport ethic of doing "whatever it takes" to win (Coakley, 2004). Uncritical acceptance of this model may lead to various health-compromising behaviors. Employing achievement goal theory, we examine why female athletes may adopt the power and performance approach. An ego motivational climate and a…

  11. 241-AY Double Shell Tanks (DST) Integrity Assessment Report

    Energy Technology Data Exchange (ETDEWEB)

    JENSEN, C.E.

    1999-09-21

    This report presents the results of the integrity assessment of the 241-AY double-shell tank farm facility located in the 200 East Area of the Hanford Site. The assessment included the design evaluation and integrity examinations of the tanks and concluded that the facility is adequately designed, is compatible with the waste, and is fit for use. Recommendations including subsequent examinations. are made to ensure the continued safe operation of the tanks.

  12. 241-AN Double Shell Tanks (DST) Integrity Assessment Report

    International Nuclear Information System (INIS)

    JENSEN, C.E.

    1999-01-01

    This report presents the results of the integrity assessment of the 241-AN double-shell tank farm facility located in the 200 East Area of the Hanford Site. The assessment included the design evaluation and integrity examinations of the tanks and concluded that the facility is adequately designed, is compatible with the waste, and is fit for use. Recommendations including subsequent examinations, are made to ensure the continued safe operation of the tanks

  13. 241-AY Double Shell Tanks (DST) Integrity Assessment Report

    International Nuclear Information System (INIS)

    JENSEN, C.E.

    1999-01-01

    This report presents the results of the integrity assessment of the 241-AY double-shell tank farm facility located in the 200 East Area of the Hanford Site. The assessment included the design evaluation and integrity examinations of the tanks and concluded that the facility is adequately designed, is compatible with the waste, and is fit for use. Recommendations including subsequent examinations, are made to ensure the continued safe operation of the tanks

  14. 241-SY Double Shell Tanks (DST) Integrity Assessment Report

    International Nuclear Information System (INIS)

    JENSEN, C.E.

    1999-01-01

    This report presents the results of the integrity assessment of the 241-SY double-shell tank farm facility located in the 200 West Area of the Hanford Site. The assessment included the design evaluation and integrity examinations of the tanks and concluded that the facility is adequately designed, is compatible with the waste, and is fit for use. Recommendations including subsequent examinations, are made to ensure the continued safe operation of the tanks

  15. 241-AZ Double-Shell Tanks (DST) Integrity Assessment Report

    International Nuclear Information System (INIS)

    JENSEN, C.E.

    1999-01-01

    This report presents the results of the integrity assessment of the 241-A2 double-shell tank farm facility located in the 200 East Area of the Hanford Site. The assessment included the design evaluation and integrity examinations of the tanks and concluded that the facility is adequately designed, is compatible with the waste, and is fit for use. Recommendations including subsequent examinations, are made to ensure the continued safe operation of the tanks

  16. 241-AW Double Shell Tanks (DST) Integrity Assessment Report

    International Nuclear Information System (INIS)

    JENSEN, C.E.

    1999-01-01

    This report presents the results of the integrity assessment of the 241-AW double-shell tank farm facility located in the 200 East Area of the Hanford Site. The assessment included the design evaluation and integrity examinations of the tanks and concluded that the facility is adequately designed, is compatible with the waste, and is fit for use. Recommendations including subsequent examinations, are made to ensure the continued safe operation of the tanks

  17. 48 CFR 239.7102-2 - Compromising emanations-TEMPEST or other standard.

    Science.gov (United States)

    2010-10-01

    ... INFORMATION TECHNOLOGY Security and Privacy for Computer Systems 239.7102-2 Compromising emanations—TEMPEST or... requiring activity is responsible for providing to the contracting officer— (a) The required protections, i...

  18. A novel lung slice system with compromised antioxidant defenses

    Energy Technology Data Exchange (ETDEWEB)

    Hardwick, S.J.; Adam, A.; Cohen, G.M. (Univ. of London (England)); Smith, L.L. (Imperial Chemical Industries PLC, Cheshire (England))

    1990-04-01

    In order to facilitate the study of oxidative stress in lung tissue, rat lung slices with impaired antioxidant defenses were prepared and used. Incubation of lung slices with the antineoplastic agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) (100 {mu}M) in an amino acid-rich medium for 45 min produced a near-maximal (approximately 85%), irreversible inhibition of glutathione reductase, accompanied by only a modest (approximately 15%) decrease in pulmonary nonprotein sulfhydryls (NPSH) and no alteration in intracellular ATP, NADP{sup +}, and NADPH levels. The amounts of NADP(H), ATP, and NPSH were stable over a 4-hr incubation period following the removal from BCNU. The viability of the system was further evaluated by measuring the rate of evolution of {sup 14}CO{sub 2} from D-({sup 14}C(U))-glucose. The rates of evolution were almost identical in the compromised system when compared with control slices over a 4-hr time period. By using slices with compromised oxidative defenses, preliminary results have been obtained with paraquat, nitrofurantoin, and 2,3-dimethoxy-1,4-naphthoquinone.

  19. A novel lung slice system with compromised antioxidant defenses

    International Nuclear Information System (INIS)

    Hardwick, S.J.; Adam, A.; Cohen, G.M.; Smith, L.L.

    1990-01-01

    In order to facilitate the study of oxidative stress in lung tissue, rat lung slices with impaired antioxidant defenses were prepared and used. Incubation of lung slices with the antineoplastic agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) (100 μM) in an amino acid-rich medium for 45 min produced a near-maximal (approximately 85%), irreversible inhibition of glutathione reductase, accompanied by only a modest (approximately 15%) decrease in pulmonary nonprotein sulfhydryls (NPSH) and no alteration in intracellular ATP, NADP + , and NADPH levels. The amounts of NADP(H), ATP, and NPSH were stable over a 4-hr incubation period following the removal from BCNU. The viability of the system was further evaluated by measuring the rate of evolution of 14 CO 2 from D-[ 14 C(U)]-glucose. The rates of evolution were almost identical in the compromised system when compared with control slices over a 4-hr time period. By using slices with compromised oxidative defenses, preliminary results have been obtained with paraquat, nitrofurantoin, and 2,3-dimethoxy-1,4-naphthoquinone

  20. Technical Evaluation Report 29: Integrated Learning Management Systems

    Directory of Open Access Journals (Sweden)

    Linda Schwartz

    2004-04-01

    Full Text Available Four integrated learning management packages were reviewed: CentraOne, IntraLearn, Lyceum, and Silicon Chalk. These products provide different combinations of synchronous and asynchronous tools. The current report examines the products in relation to their specific value for distance educators and students.

  1. A libertarian perspective on the stem cell debate: compromising the uncompromisible.

    Science.gov (United States)

    Block, Walter

    2010-08-01

    The present paper attempts to forge a compromise between those who maintain that stem cell research is out-and-out murder of young helpless human beings and those who favor this practice. The compromise is predicated upon the libertarian theory of private property rights. Starting out with the premise that not only the fetus but even the fertilized egg is a human being, with all rights thereto, it offers a competition between those who fertilize eggs for research and those who wish to adopt them. If and only if the former win this competition will they be allowed to use these very young human beings for the purposes they have constructed them. This is justified on grounds of avoiding child abuse.

  2. VISA Final Report: Fully Integrated Power Electronic Systems in Automotive Electronics

    NARCIS (Netherlands)

    Waffenschmidt, E.

    2011-01-01

    This report summarizes the activities related to the public funded project “Vollintegrierte leistungselektronische Systeme in der Automobilelektronik – VISA” (Fully Integrated Power Electronic Systems in Automotive Electronics). Aim of the project is to investigate the integration of components into

  3. Anthropogenic noise compromises antipredator behaviour in European eels.

    Science.gov (United States)

    Simpson, Stephen D; Purser, Julia; Radford, Andrew N

    2015-02-01

    Increases in noise-generating human activities since the Industrial Revolution have changed the acoustic landscape of many terrestrial and aquatic ecosystems. Anthropogenic noise is now recognized as a major pollutant of international concern, and recent studies have demonstrated impacts on, for instance, hearing thresholds, communication, movement and foraging in a range of species. However, consequences for survival and reproductive success are difficult to ascertain. Using a series of laboratory-based experiments and an open-water test with the same methodology, we show that acoustic disturbance can compromise antipredator behaviour--which directly affects survival likelihood--and explore potential underlying mechanisms. Juvenile European eels (Anguilla anguilla) exposed to additional noise (playback of recordings of ships passing through harbours), rather than control conditions (playback of recordings from the same harbours without ships), performed less well in two simulated predation paradigms. Eels were 50% less likely and 25% slower to startle to an 'ambush predator' and were caught more than twice as quickly by a 'pursuit predator'. Furthermore, eels experiencing additional noise had diminished spatial performance and elevated ventilation and metabolic rates (indicators of stress) compared with control individuals. Our results suggest that acoustic disturbance could have important physiological and behavioural impacts on animals, compromising life-or-death responses. © 2014 John Wiley & Sons Ltd.

  4. Creating clones, kids & chimera: liberal democratic compromise at the crossroads.

    Science.gov (United States)

    Adams, Nathan A

    2004-01-01

    The objective of this article is to find middle ground between the supporters and opponents of biotechnology by perpetuating the existing legal compromise pertaining to the complete range of health and welfare doctrines relevant to the biotechnological industry. The author aspires neither to add to nor detract from this liberal democratic consensus, but to preserve its constitutive balance between positivism and natural law and over-regulation and under-regulation in the hopes of stabilizing new political fault lines developing around the few biotechnological innovations already grabbing headlines. The most feasible solution is to extend the existing liberal democratic compromise with respect to equal protection, reproductive rights, the First Amendment, human subject experimentation, patent law, and parental rights. This includes banning or monopolizing certain biotechnologies and extending substantive special respect to the ex vivo living human embryo. Biotechnology must not be left to regulate itself.

  5. Treatment of chest burn contracture causing respiratory compromise with island release and grafting using cross-link collagen and Integra™ bilayer dressing

    Directory of Open Access Journals (Sweden)

    Neil Doctor

    2014-04-01

    Full Text Available Post-burn skin contractures of the anterior and lateral abdomen and chest may result in respiratory compromise due to limitation of rib excursion. This case report describes a young man with respiratory compromise limiting his daily activity and function, as a result of a 90% burn sustained 6 years previously. Release of his chest and upper abdomen was achieved using “island” scar releases and a cross-linked bovine tendon collagen and glycosaminoglycan and a semi-permeable polysiloxane bilayer matrix dressing (Integra™ followed by subsequent split thickness skin graft. An immediate increase in maximal inspiratory volume was obtained intra-operatively and in the im­mediate post-operative period, and this improvement was sustained after healing of all wounds with subjective relief of the patient’s symptoms.

  6. A Planning Approach of Engineering Characteristics Based on QFD-TRIZ Integrated

    Science.gov (United States)

    Liu, Shang; Shi, Dongyan; Zhang, Ying

    Traditional QFD planning method compromises contradictions between engineering characteristics to achieve higher customer satisfaction. However, this compromise trade-off can not eliminate the contradictions existing among the engineering characteristics which limited the overall customer satisfaction. QFD (Quality function deployment) integrated with TRIZ (the Russian acronym of the Theory of Inventive Problem Solving) becomes hot research recently for TRIZ can be used to solve contradictions between engineering characteristics which construct the roof of HOQ (House of quality). But, the traditional QFD planning approach is not suitable for QFD integrated with TRIZ for that TRIZ requires emphasizing the contradictions between engineering characteristics at problem definition stage instead of compromising trade-off. So, a new planning approach based on QFD / TRIZ integration is proposed in this paper, which based on the consideration of the correlation matrix of engineering characteristics and customer satisfaction on the basis of cost. The proposed approach suggests that TRIZ should be applied to solve contradictions at the first step, and the correlation matrix of engineering characteristics should be amended at the second step, and at next step IFR (ideal final result) must be validated, then planning execute. An example is used to illustrate the proposed approach. The application indicated that higher customer satisfaction can be met and the contradictions between the characteristic parameters are eliminated.

  7. No-compromise reptation quantum Monte Carlo

    International Nuclear Information System (INIS)

    Yuen, W K; Farrar, Thomas J; Rothstein, Stuart M

    2007-01-01

    Since its publication, the reptation quantum Monte Carlo algorithm of Baroni and Moroni (1999 Phys. Rev. Lett. 82 4745) has been applied to several important problems in physics, but its mathematical foundations are not well understood. We show that their algorithm is not of typical Metropolis-Hastings type, and we specify conditions required for the generated Markov chain to be stationary and to converge to the intended distribution. The time-step bias may add up, and in many applications it is only the middle of a reptile that is the most important. Therefore, we propose an alternative, 'no-compromise reptation quantum Monte Carlo' to stabilize the middle of the reptile. (fast track communication)

  8. Would Enforcing Competition Law Compromise Industry Policy Objectives?

    OpenAIRE

    Evenett, Simon J.

    2005-01-01

    One recurring concern in the debate over the efficacy of enacting competition laws in developing countries is that its enforcement may compromise important industrial policy goals. This concern has been raised in regional fora and in multilateral organizations such as the World Trade Organization, where officials have considered the pros and cons of including competition provisions in international trade agreements. However, the concern is broader and often national debates over the merits of...

  9. Nova Scotia wind integration study : final report

    International Nuclear Information System (INIS)

    2008-01-01

    An independent study was commissioned by the Nova Scotia Department of Energy to identify and assess the impacts of integrating large scale wind power generation into Nova Scotia's electric power system. The purpose of the study was to help Nova Scotia's efforts towards building its renewable energy supply, in order to secure a local energy resource and to protect the environment. This report provided an overview of Nova Scotia's electric power sector, including organizations involved; existing generation system; existing transmission system; renewable energy standards; Nova Scotia Power integrated resource plan; and 2007 renewable energy request for proposals. The major assumptions for the study that were discussed included system parameters; system capacity reserve requirements; expansion plans to 2020; and allocation of new wind generation by zone. Wind resource data and system dispatch modeling were also presented and transmission system modeling was outlined. This included a discussion of steady state reliability requirements; inputs to the load flow model; load flow study and contingency analysis; intra-province transmission congestion; and potential impacts on system security. The report also presented an approach to impact analysis and mitigation such as the impact on greenhouse gas and other air emissions and the impact of wind energy prices on system costs. It was concluded that one of the most important factors in evaluation of the economic impact of wind power integration is the forecasted fuel prices for the thermal units. If the fuel prices had varied significantly from the forecasted values, the study economic impact results could have been quite different. 55 tabs., 64 figs., 1 appendix

  10. Buried Waste Integrated Demonstration Technology Preparedness and Status Report Guidance

    International Nuclear Information System (INIS)

    Blacker, P.B.; Bonnenberg, R.W.; Cannon, P.G.; Hyde, R.A.; Watson, L.R.

    1994-04-01

    A Technology Preparedness and Status Report is required for each Technical Task Plan funded by the Buried Waste Integrated Demonstration. This document provides guidance for the preparation of that report. Major sections of the report will include a subset of the need for the technology, objectives of the demonstration, technology description and readiness evaluation, demonstration requirements, and preparedness checklist and action plan

  11. GEOREFERENCING IN GNSS-CHALLENGED ENVIRONMENT: INTEGRATING UWB AND IMU TECHNOLOGIES

    Directory of Open Access Journals (Sweden)

    C. K. Toth

    2017-05-01

    Full Text Available Acquiring geospatial data in GNSS compromised environments remains a problem in mapping and positioning in general. Urban canyons, heavily vegetated areas, indoor environments represent different levels of GNSS signal availability from weak to no signal reception. Even outdoors, with multiple GNSS systems, with an ever-increasing number of satellites, there are many situations with limited or no access to GNSS signals. Independent navigation sensors, such as IMU can provide high-data rate information but their initial accuracy degrades quickly, as the measurement data drift over time unless positioning fixes are provided from another source. At The Ohio State University’s Satellite Positioning and Inertial Navigation (SPIN Laboratory, as one feasible solution, Ultra- Wideband (UWB radio units are used to aid positioning and navigating in GNSS compromised environments, including indoor and outdoor scenarios. Here we report about experiences obtained with georeferencing a pushcart based sensor system under canopied areas. The positioning system is based on UWB and IMU sensor integration, and provides sensor platform orientation for an electromagnetic inference (EMI sensor. Performance evaluation results are provided for various test scenarios, confirming acceptable results for applications where high accuracy is not required.

  12. Principles of treatment planning for compromised first permanent molars in mixed dentition period: A review article

    Directory of Open Access Journals (Sweden)

    Behrad Tanbakuchi

    2017-02-01

    Full Text Available Background and Aims: The first permanent molar is susceptible to caries, endodontic complications and developmental anomalies. Compromised teeth with poor prognosis could cause the clinician to face dilemmas. The aim of this review article was to assess recent guidelines on the treatment planning of compromised first permanent molars in mixed dentition period. Materials and Methods: The design of the study was based on review of literature by searching the MEDLINE, Web of science and Google scholar. Key words (permanent first molar, extraction, treatment plan were used. This search was limited to the English articles published after the year 2000. Conclusion: A number of factors influenced decision-making process regarding compromised first permanent molars including the restorative status of the tooth, dental age of the patient, degree of crowding and occlusal relationships were assessed. The ideal time for removal of these teeth was 8-9 years of age. However, the current evidence for managing compromised first permanent molars demands clinical trials.

  13. National Acid Precipitation Assessment Program: 1990 Integrated Assessment report

    International Nuclear Information System (INIS)

    1991-11-01

    The document, the 'Integrated Assessment,' is a summary of the causes and effects of acidic deposition and a comparison of the costs and effectiveness of alternative emission control scenarios. In developing the 'Integrated Assessment,' it was NAPAP's goal to produce a structured compilation of policy-relevant technical information. The Integrated Assessment is based on findings and data from a series of twenty-seven State-of-Science/Technology Reports (SOS/T) on acidic deposition published by NAPAP in 1990. The scope of the documents includes: (1) emissions, atmospheric processes and deposition; (2) effects on surface waters, forests, agricultural crops, exposed materials, human health, and visibility; and (3) control technologies, future emissions, and effects valuation

  14. Regenerative Needs Following Alveolar Ridge Preservation Procedures in Compromised and Noncompromised Extraction Sockets: A Cone Beam Computed Tomography Study.

    Science.gov (United States)

    Koutouzis, Theofilos; Lipton, David

    2016-01-01

    The aim of this study was to evaluate the necessity for additional regenerative procedures following healing of compromised and noncompromised extraction sockets with alveolar ridge preservation procedures through the use of virtual implant imaging software. The cohort was comprised of 87 consecutive patients subjected to a single maxillary tooth extraction with an alveolar ridge preservation procedure for subsequent implant placement. Patients were divided into two main groups based on the integrity of the buccal bone plate following teeth extraction. Patients in the compromised socket (CS) group (n = 52) had partial or complete buccal bone plate loss, and patients in the noncompromised socket (NCS) group (n = 35) exhibited no bone loss of their socket walls following tooth extraction. Following 4 to 6 months of healing, all patients had a cone beam computed tomography (CBCT) study. Root-formed implants were placed virtually in an ideal prosthetic position. The number of implants per group and location (anterior, premolar, molar) exhibiting exposed buccal implant surface was calculated. In the CS group, 5 out of 19 anterior implants (26.3%), 4 out of 14 premolar implants (28.5%), and 7 out of 19 molar implants (36.8%) had exposed buccal surfaces. In the NCS group, 4 out of 9 anterior implants (44.4%), 2 out of 9 premolar implants (22.2%), and 4 out of 17 molar implants (23.5%) had exposed buccal surfaces. There were no statistically significant differences for intragroup and intergroup comparisons (χ² test, P > .05). This study failed to find statistically significant differences in the frequency of implants with exposed buccal surfaces placed virtually, following treatment of compromised and noncompromised sockets. A high proportion (22% to 44%) of sites had implants that potentially needed additional regenerative procedures.

  15. Operational test report, integrated system test (ventilation upgrade)

    International Nuclear Information System (INIS)

    HARTY, W.M.

    1999-01-01

    Operational Final Test Report for Integrated Systems, Project W-030 (Phase 2 test, RECIRC and HIGH-HEAT Modes). Project W-030 provides a ventilation upgrade for the four Aging Waste Facility tanks, including upgraded vapor space cooling and filtered venting of tanks AY101, AY102, AZ101, AZ102

  16. Operational test report integrated system test (ventilation upgrade)

    Energy Technology Data Exchange (ETDEWEB)

    HARTY, W.M.

    1999-10-05

    Operational Final Test Report for Integrated Systems, Project W-030 (Phase 2 test, RECIRC and HIGH-HEAT Modes). Project W-030 provides a ventilation upgrade for the four Aging Waste Facility tanks, including upgraded vapor space cooling and filtered venting of tanks AY101, Ay102, AZ101, AZ102.

  17. Environmetal report 2016. Impulses for an integrative environmental policy; Umweltgutachten 2016. Impulse fuer eine integrative Umweltpolitik

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-08-01

    The ecological challenges in the EU and Germany are so large that they can no longer simply be addressed using the remedial and even the technically-oriented, preventive environmental protection measures of the past. In relation to climate protection and many other fields, impacts on natural ecosystems must be substantially reduced in order to ensure that key ecosystem services remain functional. Yet, environmental policies continue to encounter stiff opposition, which is targeted at supposedly unnecessary regulatory burdens and restrictions. Opponents of environmental protection claim that environmental policies jeopardize the competitiveness of the German industrial and agricultural sectors by imposing unduly high costs. Or they bring up social issues, such as the current housing crisis or energy poverty, as arguments against an effective environmental policy. Such arguments call for nuanced assessments - and in some cases should be clearly rejected. Defusing such conflicts calls for approaches that promote compromise and that appeal to the general public. In the Environmental Report 2016, the German Advisory Council on the Environment (SRU) sets itself the task of addressing this challenge, by focusing on six key topics. What these topics all have in common is that they exhibit tensions between environmental and economic or social policy goals. The Environmental Report aims to stimulate ideas about environmental oriented reforms and approaches to managing these issues which cut across policy fields.

  18. Performance Sustainability and Integrated Reporting: Empirical Evidence from Mandatory and Voluntary Adoption Contexts

    Directory of Open Access Journals (Sweden)

    Salvatore Loprevite

    2018-04-01

    Full Text Available This paper looks at the topic of regulation of integrated reporting for listed companies, with the aim of contributing to the debate on the usefulness of introducing a mandatory regime, both from the perspective of integrated performance sustainability of companies and from that of relevance of information for providers of financial capital. The study is based on empirical research carried out on a sample composed of companies operating in territories where the adoption of integrated reporting is voluntary (Europe and those operating in a country where adoption is mandatory (South Africa. The research shows that (a in voluntary regimes, levels of integrated performance achieved by companies are higher; (b mandatory regulation produces positive effects on integrated performance levels in the medium term; (c integrated performance indicators are value-relevant, though having different levels of relevance under the two regimes examined.

  19. Management of periodontally compromised patient by orthodontic treatment: Does it help esthetically and biologically?

    Directory of Open Access Journals (Sweden)

    Subhash C Rao

    2012-01-01

    Full Text Available Adults are always keen to know whether they can still opt for orthodontic treatment and they often ask the same question to the orthodontist and the orthodontist replies, it primarily depends on the health of the bone supporting the teeth. Yes, it is the bone health which is of prime importance to undergo orthodontic treatment. Here is a case report of a patient who underwent orthodontic treatment because of lower midline spacing and protrusion of the upper anteriors. The bone health of the upper and lower anteriors was compromised. At the end of the treatment, there was marked improvement in the bone level and the profile of the patient.

  20. Secretion of salivary statherin is compromised in uncontrolled diabetic patients

    Directory of Open Access Journals (Sweden)

    Masahiro Izumi

    2015-06-01

    Conclusions and general significance: The results show that synthesis and secretion of statherin is reduced in diabetics and this reduction is salivary gland specific. As compromised salivary statherin secretion leads to increased oral health risk, this study indicates that routine oral health assessment of these patients is warranted.

  1. Influence of political opposition and compromise on conservation outcomes in the Tongass National Forest, Alaska.

    Science.gov (United States)

    Beier, Colin M

    2008-12-01

    To understand how a highly contentious policy process influenced a major conservation effort, I examined the origins, compromises, and outcomes of the Alaska National Interest Lands Conservation Act of 1980 (ANILCA) for the Tongass National Forest. Tongass wilderness designation was among the most controversial issues in the ANILCA debate, and it faced strong opposition from influential lawmakers, land managers, and Alaska residents. To investigate the influence of this opposition on Tongass conservation outcomes, I conducted a gap analysis of Tongass reserves and a policy analysis of the ANILCA debate and traced the influence of specific interests through the amendments, negotiations, and resulting compromises needed to enact ANILCA. Overall, I found that Tongass reserves comprise a broadly representative cross-section of ecosystems and species habitats in southeastern Alaska. Redrawn reserve boundaries, industry subsidies, and special access regulations reflected compromises to minimize the impact of wilderness conservation on mining, timber, and local stakeholder interests, respectively. Fragmentation of the Admiralty Island National Monument-the most ecologically valuable and politically controversial reserve-resulted from compromises with Alaskan Native (indigenous peoples of Alaska) corporations and timber interests. Despite language to accommodate "reasonable access" to wilderness reserves, ongoing access limitations highlight the concerns of Alaska residents that opposed ANILCA several decades ago. More broadly, the Tongass case suggests that early and ambitious conservation action may offset strong political opposition; compromises needed to establish key reserves often exacerbate development impacts in unprotected areas; and efforts to minimize social conflicts are needed to safeguard the long-term viability of conservation measures.

  2. Diagnosis of hemodynamic compromise in patients with chronic cerebral ischemia

    International Nuclear Information System (INIS)

    Kuroda, Satoshi; Sakuragi, Mitsugi; Motomiya, Mineo; Nakagawa, Tango; Mitsumori, Kenji; Tsuru, Mitsuo; Takigawa, Shugo; Kamiyama, Hiroyasu; Abe, Hiroshi.

    1990-01-01

    To evaluate the efficacy of tests for selecting patients with hemodynamic compromise, measurement of cerebral blood volume (CBV) with 99m Tc-RBC single photon emission computed tomography (SPECT) was performed in thirteen patients with occlusive cerebrovascular disease, and was compared with results obtained by 133 Xe SPECT and acetazolamide (Diamox) test. All patients in our study suffered TIA, RIND, or minor completed stroke. Cerebral angiography demonstrated severe stenosis or occlusion in the ipsilateral internal carotid artery or middle cerebral artery, although plain CT scan or MRI revealed no or, if any, only localized infarcted lesions. Regional cerebral blood volume (rCBV) was measured with 99m Tc-RBC SPECT and regional cerebral blood flow (rCBF) was measured with 133 Xe SPECT before and after intravenous injection of 10 - 12 mg/kg acetazolamide (Diamox). Our results suggest that the ipsilateral rCBV/rCBF (mean transit time) is a more sensitive index of the cerebral perfusion reserve than the use of only rCBV or rCBF of the ipsilateral hemisphere. Also, the ipsilateral rCBV/rCBF is significantly correlated (r= -0.72) with the Diamox reactivity of rCBF, which is considered to represent the cerebral vasodilatory capacity in patients with chronic cerebral ischemia. Postoperative SPECT study revealed remarkable improvement of ipsilateral rCBV/rCBF and Diamox reactivity in four patients who underwent EC/IC bypass surgery to improve the hemodynamic compromise. In conclusion, our results suggest that the measurement of rCBV/rCBF with 133 Xe SPECT and 99m Tc-RBC SPECT is useful for detecting the hemodynamic compromise in patients with occlusive cerebrovascular disease. (author)

  3. Transient Social-Ecological Stability: the Effects of Invasive Species and Ecosystem Restoration on Nutrient Management Compromise in Lake Erie

    Directory of Open Access Journals (Sweden)

    Eric D. Roy

    2010-03-01

    Full Text Available Together, lake ecosystems and local human activity form complex social-ecological systems (SESs characterized by feedback loops and discontinuous change. Researchers in diverse fields have suggested that complex systems do not have single stable equilibria in the long term because of inevitable perturbation. During this study, we sought to address the general question of whether or not stable social-ecological equilibria exist in highly stressed and managed lacustrine systems. Using an integrated human-biophysical model, we investigated the impacts of a species invasion and ecosystem restoration on SES equilibrium, defined here as a compromise in phosphorus management among opposing stakeholders, in western Lake Erie. Our integrated model is composed of a calibrated ecological submodel representing Sandusky Bay, and a phosphorus management submodel that reflects the societal benefits and costs of phosphorus regulation. These two submodels together form a dynamic feedback loop that includes freshwater ecology, ecosystem services, and phosphorus management. We found that the invasion of dreissenid mussels decreased ecosystem resistance to eutrophication, necessitating increased phosphorus management to preserve ecosystem services and thus creating the potential for a shift in social-ecological equilibrium. Additionally, our results suggest that net benefits in the region following the invasion of dreissenids may never again reach the pre-invasion level if on-site phosphorus control is the sole management lever. Further demonstrating transient system stability, large-scale wetland restoration shifted points of management compromise to states characterized by less on-site phosphorus management and higher environmental quality, resulting in a significant increase in net benefits in the region. We conclude that lacustrine SESs are open and dynamic, and we recommend that future models of these systems emphasize site-specific perturbation over

  4. Data Integrity: Why Aren't the Data Accurate? AIR 1989 Annual Forum Paper.

    Science.gov (United States)

    Gose, Frank J.

    The accuracy and reliability aspects of data integrity are discussed, with an emphasis on the need for consistency in responsibility and authority. A variety of ways in which data integrity can be compromised are discussed. The following sources of data corruption are described, and the ease or difficulty of identification and suggested actions…

  5. Task 10 - technology development integration. Semi-annual report, April 1--September 30, 1996

    International Nuclear Information System (INIS)

    Hendrikson, J.G.; Daly, D.J.

    1997-01-01

    The Energy and Environmental Research Center (EERC), in conjunction with the Waste Policy Institute (WPI), will identify and integrate new technologies to meet site-specific environmental management (EM) requirements at contaminated sites appropriate to U.S. Department of Energy (DOE) interests. This paper briefly reports overall progress for three activities: technology management, project management, and technology integration. Work performed over the reporting period has focused on providing logistical and administrative support. In addition, six monthly WPI reports to the EERC are included as appendices. The WPI reports contained detailed information for progress in each activity

  6. Environmental performance and financial report integrity: challenges for the mining sector in Indonesia

    Science.gov (United States)

    Mayangsari, S.

    2018-01-01

    This study investigates the influence of environmental performance on the financial report integrity. The statistics used were primary data from interviews with senior members of the mining sector regarding environmental issues, as well as secondary data using Financial Report 2016. The samples were listed mining companies with semester data. Questionnaires were used to measure their perceptions of the challenges concerning climate change faced by the mining sector. The results of this research show that regulatory interventions will be critical to environmental issues. This study employed KLD as a proxy for environmental performance, correlated with other variables regarding the integrity of disclosure. The outcome indicates that environmental issues will increase the integrity of financial reports.

  7. Compromises in energy policy-Using fuzzy optimization in an energy systems model

    International Nuclear Information System (INIS)

    Martinsen, Dag; Krey, Volker

    2008-01-01

    Over the last year in Germany a great many political discussions have centered around the future direction of energy and climate policy. Due to a number of events related to energy prices, security of supply and climate change, it has been necessary to develop cornerstones for a new integrated energy and climate policy. To supplement this decision process, model-based scenarios were used. In this paper we introduce fuzzy constraints to obtain a better representation of political decision processes, in particular, to find compromises between often contradictory targets (e.g. economic, environmentally friendly and secure energy supply). A number of policy aims derived from a review of the ongoing political discussions were formulated as fuzzy constraints to explicitly include trade-offs between various targets. The result is an overall satisfaction level of about 60% contingent upon the following restrictions: share of energy imports, share of biofuels, share of CHP electricity, CO 2 reduction target and use of domestic hard coal. The restrictions for the share of renewable electricity, share of renewable heat, energy efficiency and postponement of nuclear phase out have higher membership function values, i.e. they are not binding and therefore get done on the side

  8. Autobiographical memory compromise in Alzheimer's disease: a cognitive and clinical overview.

    Science.gov (United States)

    El Haj, Mohamad; Roche, Jean; Gallouj, Karim; Gandolphe, Marie-Charlotte

    2017-12-01

    Autobiographical memory refers to memory for personal information. The compromise of autobiographical memory in Alzheimer's disease (AD) results in a loss of knowledge about events and facts that defined the patients' life, and consequently, degradation of their self-knowledge and sense of identity. The compromise of autobiographical memory in AD can be attributed to a diminished subjective experience of memory and a diminished sense of the self. Our review provides a comprehensive overview of cognitive and clinical processes that may be involved in difficulties to retrieve autobiographical memories in Alzheimer's disease. Our review also proposes a theoretical model according to which, the diminished ability to retrieve contextual information and the overgenerality of recall result in a diminished subjective experience of past and future thinking. Besides its theoretical contribution, our review proposes clinical applicability for evaluation and rehabilitation of autobiographical memory in AD.

  9. The role of hypoxia-induced factor in the regulation of oxygen homeostasis during reparative regeneration in compromised microcirculation

    Directory of Open Access Journals (Sweden)

    S. G. Izmaylov

    2017-01-01

    Full Text Available The aim of the present review is to find an answer to the clinically important question on the mechanisms regulating the activity of reparative regeneration in hypoxic conditions and potential ways to modify this process. In the recent studies, compensated hypoxia is characterized as a trigger for the regeneration, with the central regulating factor being the member of the cytokine family, hypoxia-inducible factor-1 (HIF-1. Changes in the concentration of this protein modulates cell migration, angiogenesis and epithelialmesenchymal integration; it also stimulates the proliferation of endothelial cells and fibroblasts, playing a  major role in the stimulation of wound healing, especially with compromised microcirculation, for example, diabetes mellitus. 

  10. Apotemnophilia or body integrity identity disorder: a case report review.

    Science.gov (United States)

    Bou Khalil, Rami; Richa, Sami

    2012-12-01

    Apotemnophilia or body integrity identity disorder (BIID) denotes a syndrome in which a person is preoccupied with the desire to amputate a healthy limb. In this report, we review the available case reports in the literature in order to enhance psychiatrists' and physicians' comprehension of this disorder. A search for the case reports available via MEDLINE was done since the first case report published by Money et al in 1977 till May 2011, using the following terms: apotemnophilia, self-demand amputation, body integrity identity disorder, and BIID. In all, 14 case reports were found relevant to our search. The desire to amputate one's healthy limb seems to be related to a major disturbance in the person's perception of one's own identity, where limb amputation can relieve temporarily the patient's feeling of distress without necessarily and uniformly adjusting the patient's own identity misperception. More investigations are needed in this domain in order to develop noninvasive treatment strategies that approach this aspect of the patient's distress within a globalist perspective. In addition, the health professionals' awareness regarding this disorder is required to ensure professional management of patients' suffering.

  11. Post-fine-needle aspiration biopsy communication and the integrated and standardized cytopathology report.

    Science.gov (United States)

    Pitman, Martha B; Black-Schaffer, W Stephen

    2017-06-01

    Communication between cytopathologists and patients and their care team is a critical component of accurate and timely patient management. The most important single means of communication for the cytopathologist is through the cytopathology report. Implementation of standardized terminology schemes and structured, templated reporting facilitates the ability of the cytopathologist to provide a comprehensive and integrated report. Cytopathology has been among the pathology subspecialties that have led the way in developing standardized reporting, beginning with the 1954 Papanicolaou classification scheme for cervical-vaginal cytology and continuing through the Bethesda systems for gynecological cytology and several nongynecological cytology systems. The effective reporting of cytopathology necessarily becomes more complex as it addresses increasingly sophisticated management options, requiring the integration of information from a broader range of sources. In addition to the complexity of information inputs, a wider spectrum of consumers of these reports is emerging, from patients themselves to primary care providers to subspecialized disease management experts. Both these factors require that the reporting cytopathologist provide the integration and interpretation necessary to translate diverse forms of information into meaningful and actionable reports that will inform the care team while enabling the patient to meaningfully participate in his or her own care. To achieve such broad and focused communications will require first the development of standardized and integrated reports and ultimately the involvement of cytopathologists in the development of the clinical informatics needed to treat all these items of information as structured data elements with flexible reporting operators to address the full range of patient and patient care needs. Cancer Cytopathol 2017;125(6 suppl):486-93. © 2017 American Cancer Society. © 2017 American Cancer Society.

  12. A modeling ontology for integrating vulnerabilities into security requirements conceptual foundations

    NARCIS (Netherlands)

    Elahi, G.; Yu, E.; Zannone, N.; Laender, A.H.F.; Castano, S.; Dayal, U.; Casati, F.; Palazzo Moreira de Oliveira, J.

    2009-01-01

    Vulnerabilities are weaknesses in the requirements, design, and implementation, which attackers exploit to compromise the system. This paper proposes a vulnerability-centric modeling ontology, which aims to integrate empirical knowledge of vulnerabilities into the system development process. In

  13. Report: Recommendation to Strengthen Management Integrity Processes Affecting Recovery Act Activities

    Science.gov (United States)

    Report #09-X-0145, April 27, 2009. The EPA OIG has completed a review of the Agency’s Fiscal Year (FY) 2009 Management Integrity guidance for reporting on internal control reviews and preparing the annual assurance letters sent to the Administrator.

  14. Iran. Nuclear crisis: the continuous compromise?

    International Nuclear Information System (INIS)

    Cherief, Hamza

    2016-01-01

    The author comments and discusses the content and implications of the Joint Comprehensive Plan of Action which has been adopted in July 2015 by the Republic of Iran and the members of the E3/EU+3 group. According to this text, a flexible normative and institutional framework is defined, according to which negotiation must prevail on the reinstatement of economic sanctions. While significantly lowering objectives related to non proliferation, this plan aims (through various arrangements which are discussed by the author) at maintaining Iran under the threshold of nuclear power. The author also comments various aspects related to the implementation of this Plan of Action, and outlines that they rely on the search for a continuous compromise: negotiations and involvement of international bodies are foreseen before application of sanctions

  15. A method for identifying compromised clients based on DNS traffic analysis

    DEFF Research Database (Denmark)

    Stevanovic, Matija; Pedersen, Jens Myrup; D’Alconzo, Alessandro

    2017-01-01

    DNS is widely abused by Internet criminals in order to provide reliable communication within malicious network infrastructure as well as flexible and resilient hosting of malicious content. This paper presents a novel detection method that can be used for identifying potentially compromised clien...

  16. Online Learning Integrity Approaches: Current Practices and Future Solutions

    Science.gov (United States)

    Lee-Post, Anita; Hapke, Holly

    2017-01-01

    The primary objective of this paper is to help institutions respond to the stipulation of the Higher Education Opportunity Act of 2008 by adopting cost-effective academic integrity solutions without compromising the convenience and flexibility of online learning. Current user authentication solutions such as user ID and password, security…

  17. How do current public integrated reports align with the

    NARCIS (Netherlands)

    Hurks, P.; Langendijk, H.P.A.J.; Nandram, K.

    2015-01-01

    This paper examines empirically the current practice with regard to integrated reporting according to the IR Framework among the 104 original participants (companies) of the IIRC Pilot program. We made a selection with respect to these 104 participants based on organization’s stipulation that they

  18. Live attenuated S. Typhimurium vaccine with improved safety in immuno-compromised mice.

    Directory of Open Access Journals (Sweden)

    Balamurugan Periaswamy

    Full Text Available Live attenuated vaccines are of great value for preventing infectious diseases. They represent a delicate compromise between sufficient colonization-mediated adaptive immunity and minimizing the risk for infection by the vaccine strain itself. Immune defects can predispose to vaccine strain infections. It has remained unclear whether vaccine safety could be improved via mutations attenuating a vaccine in immune-deficient individuals without compromising the vaccine's performance in the normal host. We have addressed this hypothesis using a mouse model for Salmonella diarrhea and a live attenuated Salmonella Typhimurium strain (ssaV. Vaccination with this strain elicited protective immunity in wild type mice, but a fatal systemic infection in immune-deficient cybb(-/-nos2(-/- animals lacking NADPH oxidase and inducible NO synthase. In cybb(-/-nos2(-/- mice, we analyzed the attenuation of 35 ssaV strains carrying one additional mutation each. One strain, Z234 (ssaV SL1344_3093, was >1000-fold attenuated in cybb(-/-nos2(-/- mice and ≈100 fold attenuated in tnfr1(-/- animals. However, in wt mice, Z234 was as efficient as ssaV with respect to host colonization and the elicitation of a protective, O-antigen specific mucosal secretory IgA (sIgA response. These data suggest that it is possible to engineer live attenuated vaccines which are specifically attenuated in immuno-compromised hosts. This might help to improve vaccine safety.

  19. Acute gastrointestinal compromise in neonates with congenital diaphragmatic hernia prior to repair.

    Science.gov (United States)

    Fox, Catherine; Stewart, Michael; King, Sebastian K; Patel, Neil

    2016-12-01

    Congenital diaphragmatic hernia (CDH) affects 1 in 3000 live births. Modern management strategies include delayed repair of the diaphragm to permit pre-operative optimization of cardiorespiratory status. We describe a cohort of neonates in whom early emergency operative intervention was required for potentially fatal intestinal compromise. A retrospective review was performed of all neonatal CDH patients managed at a tertiary center in an 8-year period (2005-2012). A total of 126 CDH patients were managed during the 8-year period. Five neonates (male - 1; gestation 37+4-39+7; birth weight 2.9-3.7kg; left CDH - 5) required emergency operative intervention for presumed gastrointestinal compromise. All five neonates demonstrated systemic hypotension despite inotropic support, raised serum lactate (>2mmol/L), and abnormal radiographic findings. Operative intervention occurred within 3days of birth (1-3days). Findings included gastric volvulus, jejunal volvulus, and perforated caecum. All patients underwent primary diaphragmatic repair without a patch. Temporary ileostomy was required in 1 patient. All patients remain alive. Gastrointestinal compromise is a rare, but potentially catastrophic, complication of CDH. Emergency operative intervention may be required in a select cohort of patients. Early deterioration following birth should alert clinicians to the possibility of significant intestinal pathology. Level IV case series with no comparison group. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Parental care compromises feeding in the pumpkinseed ( Lepomis gibbosus)

    Science.gov (United States)

    Zięba, G.; Dukowska, M.; Przybylski, M.; Fox, M. G.; Smith, C.

    2018-04-01

    Providing parental care is potentially costly. Costs can arise through elevated energy expenditure or from an increased risk of mortality. A cost of parental care can also occur because a parent is compromised in their ability to forage. We used pumpkinseed Lepomis gibbosus, a fish with an alternative male mating strategy, to test whether parental males differed in their feeding in comparison with females and cuckolder males. To address this question, we examined the stomach contents of female, cuckolder male, and parental male pumpkinseed during the breeding season over an entire diel cycle. We showed that parental males had a lower total weight of food in their stomachs in comparison with females, while cuckolder males did not. Parental males also had a lower weight and number of chironomids in their stomachs. The temporal pattern of feeding of parental males diverged from that of females, and they had a lower probability of pupal chironomids in their stomachs, which implies spatial segregation in foraging. Parental males had a greater probability of conspecific eggs in their stomachs than females, while the probability of egg cannibalism did not differ between cuckolder males and females. Overall, these finding meet predictions in accordance with an assumption that parental care and territoriality can compromise feeding.

  1. 7 CFR 4290.1710 - Secretary's authority to collect or compromise claims.

    Science.gov (United States)

    2010-01-01

    ... BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL BUSINESS INVESTMENT COMPANY (âRBICâ) PROGRAM Financial Assistance for RBICs (Leverage) Miscellaneous § 4290.1710... consideration as he or she deems reasonable, collect or compromise all claims relating to obligations he or she...

  2. Solar thermal repowering systems integration. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Dubberly, L. J.; Gormely, J. E.; McKenzie, A. W.

    1979-08-01

    This report is a solar repowering integration analysis which defines the balance-of-plant characteristics and costs associated with the solar thermal repowering of existing gas/oil-fired electric generating plants. Solar repowering interface requirements for water/steam and salt or sodium-cooled central receivers are defined for unit sizes ranging from 50 MWe non-reheat to 350 MWe reheat. Finally balance-of-plant cost estimates are presented for each of six combinations of plant type, receiver type and percent solar repowering.

  3. CLINICAL CASE OF TREATMENT WITH RIBOSOMAL COMPLEX IN CHILD WITH COMPROMISED IMMUNITY

    Directory of Open Access Journals (Sweden)

    A.A. Alekseeva

    2011-01-01

    Full Text Available The leading pathology in children is acute respiratory infections (ARI according to the expert data of WHO. The incidence of prolonged and recurrent types of ARI increases during recent years. Patients with these diseases subsequently form the group of children with compromised immunity. Immunogens and immunomodulators are the drugs of nonspecific prophylaxis which are used for the prevention of ARI. The group of bacterial immunomodulators is big but most well-studied systemic drug from this group is Ribomunyl. Ribosomal complex is effective and safe in pediatric practice. The article presents the clinical case of treatment with ribosomal complex in immunocompronised child with allergic pathology.Key words: children with compromised immunity, allergy, acute respiratory infections, treatment.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (2: 211–215

  4. Integrated reporting – innovation in accounting paradigms

    Directory of Open Access Journals (Sweden)

    Mirosława Kwiecień

    2016-07-01

    Full Text Available The article is an introduction to the issues and results of a new trend in interdisciplinary research, which is integrated reporting. „Violated balance”, characteristic of contemporary global economy, forces us to seek solutions oriented to symbiosis between economic, social and environmental progress, which is the basis for fundamental changes in mental models that determine the way the economic organization oper-ates. On the basis of literature studies, as well as management (of innovation, knowledge, etc. science studies and research on changes in legal regulations of accounting, one can venture to say that the change in accounting paradigms is an innovation which stems from legal requirements. Legislation stimulates conceptuality, including information management, standardization of accounting, etc. Innovation theory refers to technological, organizational and market changes, so a question ariseswhether this theory can be applied to accounting practices as well? In this way an idea emerged for inves-tigating the question if the implementation of legal regulations such as International Financial Reporting Standards (IFRS or the standards of the Global Reporting Initiative (GRI is a manifestation of the inno-vation theory in the development of accounting systems, especially in reporting.

  5. Integrated safety assessment report, Haddam Neck Plant (Docket No. 50-213): Integrated Safety Assessment Program: Draft report

    International Nuclear Information System (INIS)

    1987-07-01

    The integrated assessment is conducted on a plant-specific basis to evaluate all licensing actions, licensee initiated plant improvements and selected unresolved generic/safety issues to establish implementation schedules for each item. Procedures allow for a periodic updating of the schedules to account for licensing issues that arise in the future. The Haddam Neck Plant is one of two plants being reviewed under the pilot program. This report indicates how 82 topics selected for review were addressed, and presents the staff's recommendations regarding the corrective actions to resolve the 82 topics and other actions to enhance plant safety. 135 refs., 4 figs., 5 tabs

  6. Compromised Rivers: Understanding Historical Human Impacts on Rivers in the Context of Restoration

    Directory of Open Access Journals (Sweden)

    Ellen Wohl

    2005-12-01

    Full Text Available A river that preserves a simplified and attractive form may nevertheless have lost function. Loss of function in these rivers can occur because hydrologic and geomorphic processes no longer create and maintain the habitat and natural disturbance regimes necessary for ecosystem integrity. Recognition of compromised river function is particularly important in the context of river restoration, in which the public perception of a river's condition often drives the decision to undertake restoration as well as the decision about what type of restoration should be attempted. Determining the degree to which a river has been altered from its reference condition requires a knowledge of historical land use and the associated effects on rivers. Rivers of the Front Range of the Colorado Rocky Mountains in the United States are used to illustrate how historical land uses such as beaver trapping, placer mining, tie drives, flow regulation, and the construction of transportation corridors continue to affect contemporary river characteristics. Ignorance of regional land use and river history can lead to restoration that sets unrealistic goals because it is based on incorrect assumptions about a river's reference condition or about the influence of persistent land-use effects.

  7. 17D yellow fever vaccine elicits comparable long-term immune responses in healthy individuals and immune-compromised patients

    NARCIS (Netherlands)

    Wieten, R. W.; Goorhuis, A.; Jonker, E. F. F.; de Bree, G. J.; de Visser, A. W.; van Genderen, P. J. J.; Remmerswaal, E. B. M.; ten Berge, I. J. M.; Visser, L. G.; Grobusch, M. P.; van Leeuwen, E. M. M.

    2016-01-01

    The 17D live attenuated yellow fever (YF) vaccine is contra-indicated in immune-compromised individuals and may elicit a suboptimal immunologic response. The aim of this study is to assess whether long-term immune responses against the YF vaccine are impaired in immune-compromised patients. Fifteen

  8. Heavy Cigarette Smokers in a Chinese Population Display a Compromised Permeability Barrier

    Science.gov (United States)

    Xin, Shujun; Ye, Li; Lv, Chengzhi; Elias, Peter M.

    2016-01-01

    Cigarette smoking is associated with various cutaneous disorders with defective permeability. Yet, whether cigarette smoking influences epidermal permeability barrier function is largely unknown. Here, we measured skin biophysical properties, including permeability barrier homeostasis, stratum corneum (SC) integrity, SC hydration, skin surface pH, and skin melanin/erythema index, in cigarette smokers. A total of 99 male volunteers were enrolled in this study. Smokers were categorized as light-to-moderate (hydration and skin melanin/erythema index on the dorsal hand, forehead, and cheek. Basal transepidermal water loss (TEWL) and barrier recovery rates were assessed on the forearm. A Skin-pH-Meter pH900 was used to measure skin surface pH. Our results showed that heavy cigarette smokers exhibited delayed barrier recovery after acute abrogation (1.02% ± 13.06 versus 16.48% ± 6.07), and barrier recovery rates correlated negatively with the number of daily cigarettes consumption (p = 0.0087). Changes in biophysical parameters in cigarette smokers varied with body sites. In conclusion, heavy cigarette smokers display compromised permeability barrier homeostasis, which could contribute, in part, to the increased prevalence of certain cutaneous disorders characterized by defective permeability. Thus, improving epidermal permeability barrier should be considered for heavy cigarette smokers. PMID:27437403

  9. Evaluation of instant cup noodle, irradiated for immuno-compromised patients

    International Nuclear Information System (INIS)

    Lee, Ji-Hye; Kim, Jae-Kyung; Park, Jae-Nam; Yoon, Young-Min; Sung, Nak-Yun; Kim, Jae-Hun; Song, Beom-Seok; Yook, Hong-Sun; Kim, Byeong-Keun; Lee, Ju-Woon

    2012-01-01

    In the present study, initial microbial load of instant cup noodle (ICN) was investigated and gamma irradiation applied to develop immuno-compromised patients food for their safe consumption. The initial microbial population of dried vegetable and meat, and noodle was below the detection limit (1 log CFU/g); however, that of seasoning powder was just above 4 log CFU/g. Moreover, rehydrated-ICN with water at 100 °C still show above 3 log CFU/g of microbial load, which indicates the need for an additional process to control microbial safety of the seasoning powder. The total aerobic bacteria in seasoning powder and rehydrated-ICN could be controlled with 17 kGy gamma irradiation. This result referred 17 kGy gamma irradiation could reach ‘practical sterility’ of ICN. The overall difference in sensory properties between the non-irradiated and irradiated ICN was insignificant. Thus, gamma irradiation could improve the microbial quality of ICN, and reduce the risk of infection posed by the seasoning powder, without any adverse effects on their sensory quality. These results suggest that gamma-irradiated ICN can be used as a snack food for immuno-compromised patients.

  10. Evaluation of instant cup noodle, irradiated for immuno-compromised patients

    Science.gov (United States)

    Lee, Ji-Hye; Kim, Jae-Kyung; Park, Jae-Nam; Yoon, Young-Min; Sung, Nak-Yun; Kim, Jae-Hun; Song, Beom-Seok; Yook, Hong-Sun; Kim, Byeong-Keun; Lee, Ju-Woon

    2012-08-01

    In the present study, initial microbial load of instant cup noodle (ICN) was investigated and gamma irradiation applied to develop immuno-compromised patients food for their safe consumption. The initial microbial population of dried vegetable and meat, and noodle was below the detection limit (1 log CFU/g); however, that of seasoning powder was just above 4 log CFU/g. Moreover, rehydrated-ICN with water at 100 °C still show above 3 log CFU/g of microbial load, which indicates the need for an additional process to control microbial safety of the seasoning powder. The total aerobic bacteria in seasoning powder and rehydrated-ICN could be controlled with 17 kGy gamma irradiation. This result referred 17 kGy gamma irradiation could reach 'practical sterility' of ICN. The overall difference in sensory properties between the non-irradiated and irradiated ICN was insignificant. Thus, gamma irradiation could improve the microbial quality of ICN, and reduce the risk of infection posed by the seasoning powder, without any adverse effects on their sensory quality. These results suggest that gamma-irradiated ICN can be used as a snack food for immuno-compromised patients.

  11. THE VALUE OF INTEGRITY IN THE REPORTS OF WORK

    Directory of Open Access Journals (Sweden)

    Simona-Roxana ULMAN

    2015-03-01

    Full Text Available The most important aim of this paper is to identify the main general ethical values conducting to personal integrity, to build the general ethical values pyramid and, so, helping to improve the reports of labor for having positive results on the economic field. In this context, the human psychological development theory thorough by Maslow is exploited as example for the building of a human values hierarchy necessary to the individual as a social being to engage in normal interactions with the others. These general values are an imperative for the person’s integration in society, also contributing to his belonging society’s welfare and to its performance.

  12. Differential diagnosis of the signal-compromised lunate in MRI

    International Nuclear Information System (INIS)

    Schmitt, R.; Christopoulos, G.; Coblenz, G.; Froehner, S.; Brunner, H.; Kalb, K.; Krimmer, H.; Lanz, U.

    2005-01-01

    Purpose: To define both the underlying pathology and diagnostic criteria in lunates presenting with conspicuous signal pattern in MRI. Materials and Methods: The retrospective evaluation of 2940 MRI examinations revealed 203 patients with signal alterations of the lunate. All MRI examinations were performed on 1.5-Tesla platforms using dedicated surface coils and an intravenous contrast agent. To establish a definitive diagnosis, a total of 252 MRI examinations (49 follow-ups), 22 CT examinations and 4 arthroscopic studies were obtained in addition to the obligatory conventional radiographs. Results: Incorporating all clinical data, radiographs and MRI examinations succeeded in assigning a diagnosis in 136 signal-compromised lunates (67.0%), whereas additional diagnostic procedures or follow-up examinations were required for the definitive diagnosis in 57 cases (33.0%). The most frequent entities were 51 cases of Kienboeck's disease (25.1%), 47 cases of ulnolunate-(triquetral) impaction syndromes (23.2%) and 44 cases of intra-osseous ganglion cysts (21.7%). Other pathologies included 23 degenerative, 19 traumatic and 10 inflammatory changes as well as 9 congenital conditions. For MRI assessment of the altered lunate, the most important parameters were location and morphology as well as involvement of the articular and osseous structures of the carpus. Conclusion: The lunate may be affected by different pathological states of the wrist. In total, only one quarter of the signal-compromised lunate represented Kienboeck's disease. (orig.)

  13. Integrated radwaste treatment system. Final report

    International Nuclear Information System (INIS)

    Baker, M.N.; Houston, H.M.

    1997-10-01

    In May 1988, the West Valley Demonstration Project (WVDP) began pretreating liquid high-level radioactive waste (HLW). This HLW was produced during spent nuclear fuel reprocessing operations that took place at the Western New York Nuclear Service Center from 1966 to 1972. Original reprocessing operations used plutonium/uranium extraction (PUREX) and thorium extraction (THOREX) processes to recover usable isotopes from spent nuclear fuel. The PUREX process produced a nitric acid-based waste stream, which was neutralized by adding sodium hydroxide to it. About two million liters of alkaline liquid HLW produced from PUREX neutralization were stored in an underground carbon steel tank identified as Tank 8D-2. The THOREX process, which was used to reprocess one core of mixed uranium-thorium fuel, resulted in about 31,000 liters of acidic waste. This acidic HLW was stored in an underground stainless steel tank identified as Tank 8D-4. Pretreatment of the HLW was carried out using the Integrated Radwaste Treatment System (IRTS), from May 1988 until May 1995. This system was designed to decontaminate the liquid HLW, remove salts from it, and encapsulate the resulting waste into a cement waste form that achieved US Nuclear Regulatory Commission (NRC) criteria for low-level waste (LLW) storage and disposal. A thorough discussion of IRTS operations, including all systems, subsystems, and components, is presented in US Department of Energy (DOE) Topical Report (DOE/NE/44139-68), Integrated Radwaste Treatment System Lessons Learned from 2 1/2 Years of Operation. This document also presents a detailed discussion of lessons learned during the first 2 1/2 years of IRTS operation. This report provides a general discussion of all phases of IRTS operation, and presents additional lessons learned during seven years of IRTS operation

  14. Vitrification Facility integrated system performance testing report

    International Nuclear Information System (INIS)

    Elliott, D.

    1997-01-01

    This report provides a summary of component and system performance testing associated with the Vitrification Facility (VF) following construction turnover. The VF at the West Valley Demonstration Project (WVDP) was designed to convert stored radioactive waste into a stable glass form for eventual disposal in a federal repository. Following an initial Functional and Checkout Testing of Systems (FACTS) Program and subsequent conversion of test stand equipment into the final VF, a testing program was executed to demonstrate successful performance of the components, subsystems, and systems that make up the vitrification process. Systems were started up and brought on line as construction was completed, until integrated system operation could be demonstrated to produce borosilicate glass using nonradioactive waste simulant. Integrated system testing and operation culminated with a successful Operational Readiness Review (ORR) and Department of Energy (DOE) approval to initiate vitrification of high-level waste (HLW) on June 19, 1996. Performance and integrated operational test runs conducted during the test program provided a means for critical examination, observation, and evaluation of the vitrification system. Test data taken for each Test Instruction Procedure (TIP) was used to evaluate component performance against system design and acceptance criteria, while test observations were used to correct, modify, or improve system operation. This process was critical in establishing operating conditions for the entire vitrification process

  15. Nucleotide excision repair : a multi-step mechanism required to maintain genome integrity

    NARCIS (Netherlands)

    Moser, Jill

    2010-01-01

    DNA is continuously exposed to exogenous and genotoxic insults including ionizing and ultraviolet radiation as well as chemical agents. DNA damage can compromise the integrity of the genome and have potentially deleterious effects. Ultraviolet light (UV) can induce the formation of helix distorting

  16. Integral Fast Reactor Program annual progress report, FY 1994

    International Nuclear Information System (INIS)

    Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, J.J.

    1994-12-01

    This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1994. Technical accomplishments are presented in the following areas of the IFR technology development activities: metal fuel performance; pyroprocess development; safety experiments and analyses; core design development; fuel cycle demonstration; and LMR technology R ampersand D

  17. Large-scale building integrated photovoltaics field trial. First technical report - installation phase

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This report summarises the results of the first eighteen months of the Large-Scale Building Integrated Photovoltaic Field Trial focussing on technical aspects. The project aims included increasing awareness and application of the technology, raising the UK capabilities in application of the technology, and assessing the potential for building integrated photovoltaics (BIPV). Details are given of technology choices; project organisation, cost, and status; and the evaluation criteria. Installations of BIPV described include University buildings, commercial centres, and a sports stadium, wildlife park, church hall, and district council building. Lessons learnt are discussed, and a further report covering monitoring aspects is planned.

  18. Value Creation Reporting: Answering the Question ‘Value to Whom’ according to the International Integrated Reporting Framework

    Directory of Open Access Journals (Sweden)

    Soner Gokten

    2017-06-01

    Full Text Available Value Creation Reporting: Answering the Question ‘Value to Whom’ according to the International Integrated Reporting Framework The principal function of integrated reporting is the reporting of value and this phenomenon seems the most philosophical part of the International Framework. This paper discusses what the value concept refers to in the Framework: Value to investors, value to society or value to present and future generations? In this sense, we try to answer this question by highlighting the dynamics of capital formations according to interrelations between capitals and demonstrating the value creation process in the short, medium, and longer term. We show that (1 „profit” is the result of short term value creation, which indicates the „value to value chain stakeholders”, (2 „expected fair value of equity” represents the „value to investors” and (3 „longer term value” represents the „value to society” according to the International Framework. Additionally, we touch on the inadequacies of the current Framework and suggest future research opportunities within the scope of value creation reporting. To our knowledge, this study is the first to provide a detailed framework on the dynamics of capitals usage and it attempts to show the intersection of accounting and finance in terms of value creation reporting.

  19. Buried waste integrated demonstration fiscal year 1992 close-out report

    International Nuclear Information System (INIS)

    Cannon, P.G.; Kostelnik, K.M.; Owens, K.J.

    1993-02-01

    The mission of the Buried Waste Integrated Demonstration Program (BWID) is to support the development and demonstration of a suite of technologies that when integrated with commercially-available baseline technologies form a comprehensive remediation system for the effective and efficient remediation of buried waste disposed of throughout the US Department of Energy complex. To accomplish this mission of identifying technological solutions for remediation deficiencies, the Office of Technology Development initiated the BWID at the Idaho National Engineering Laboratory in fiscal year (FY)-91. This report summarizes the activities of the BWID Program during FY-92

  20. Corporate Disclosure, Materiality, and Integrated Report: An Event Study Analysis

    OpenAIRE

    Maria Cleofe Giorgino; Enrico Supino; Federico Barnabè

    2017-01-01

    Within the extensive literature investigating the impacts of corporate disclosure in supporting the sustainable growth of an organization, few studies have included in the analysis the materiality issue referred to the information being disclosed. This article aims to address this gap, exploring the effect produced on capital markets by the publication of a recent corporate reporting tool, Integrated Report (IR). The features of this tool are that it aims to represent the multidimensional imp...

  1. Progress Report 15, December 1979-April 1980, and proceedings of the fifteenth Project Integration Meeting

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    Progress made by the Low-Cost Solar Array Project during the period December 1979 to April 1980 is reported. Reports on project analysis and integration; technology development in silicon material, large-area silicon sheet and encapsulation; production process and equipment development; engineering; and operations are included. Also, a report on, and copies of visual presentations made at, the Project Integration Meeting held April 2 and 3, 1980, are included.

  2. Happenstance and compromise: a gendered analysis of students' computing degree course selection

    Science.gov (United States)

    Lang, Catherine

    2010-12-01

    The number of students choosing to study computing at university continues to decline this century, with an even sharper decline in female students. This article presents the results of a series of interviews with university students studying computing courses in Australia that uncovered the influence of happenstance and compromise on course choice. This investigation provides an insight into the contributing factors into the continued downturn of student diversity in computing bachelor degree courses. Many females interviewed made decisions based on happenstance, many males interviewed had chosen computing as a compromise course, and family helped in the decision-making to a large degree in both genders. The major implication from this investigation is the finding that students of both genders appear to be socialised away from this discipline, which is perceived as a support or insurance skill, not a career in itself, in all but the most technical-oriented (usually male) student.

  3. Integral Fast Reactor Program. Annual progress report, FY 1992

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

    1993-06-01

    This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1992. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R&D.

  4. Is ridge preservation/augmentation at periodontally compromised extraction sockets safe? A retrospective study.

    Science.gov (United States)

    Kim, Jung-Ju; Ben Amara, Heithem; Schwarz, Frank; Kim, Hae-Young; Lee, Jung-Won; Wikesjö, Ulf M E; Koo, Ki-Tae

    2017-10-01

    This study aimed to evaluate the safety of ridge preservation/augmentation procedures when performed at compromised extraction sockets. Patients subject to ridge preservation/augmentation at periodontally compromised sockets at Seoul National University Dental Hospital (SNUDH) were evaluated in a chart review. Tooth extractions due to acute infection were not included in our study as chronically formed lesions are the only lesions that can be detected from radiographic images. If inflammatory symptoms persisted following ridge preservation/augmentation and antimicrobial and anti-inflammatory therapy, the patient was categorized as a re-infection case and implanted biomaterial removed. Of 10,060 patients subject to tooth extractions at SNUDH, 2011 through 2015, 297 cases meeting inclusion criteria were reviewed. The severity and type of lesions were not specific because extracting data was only done by radiographic images and chart records. The review identified eight patients exhibiting inflammatory symptoms that required additional antimicrobial and anti-inflammatory therapy. Within this group, re-infection occurred in two patients requiring biomaterials removal. The final safety rate for the ridge preservation/augmentation was 99.3%. None of the demographic factors, systemic conditions or choice of biomaterial affected the safety of ridge preservation/augmentation. Alveolar ridge preservation/augmentation at periodontally compromised sockets appears safe following thorough removal of infectious source. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. Outcomes of Soft Tissue Reconstruction for Traumatic Lower Extremity Fractures with Compromised Vascularity.

    Science.gov (United States)

    Badash, Ido; Burtt, Karen E; Leland, Hyuma A; Gould, Daniel J; Rounds, Alexis D; Azadgoli, Beina; Patel, Ketan M; Carey, Joseph N

    2017-10-01

    Traumatic lower extremity fractures with compromised arterial flow are limb-threatening injuries. A retrospective review of 158 lower extremities with traumatic fractures, including 26 extremities with arterial injuries, was performed to determine the effects of vascular compromise on flap survival, successful limb salvage and complication rates. Patients with arterial injuries had a larger average flap surface area (255.1 vs 144.6 cm2, P = 0.02) and a greater number of operations (4.7 vs 3.8, P = 0.01) than patients without vascular compromise. Patients presenting with vascular injury were also more likely to require fasciotomy [odds ratio (OR): 6.5, confidence interval (CI): 2.3-18.2] and to have a nerve deficit (OR: 16.6, CI: 3.9-70.0), fracture of the distal third of the leg (OR: 2.9, CI: 1.15-7.1) and intracranial hemorrhage (OR: 3.84, CI: 1.1-12.9). After soft tissue reconstruction, patients with arterial injuries had a higher rate of amputation (OR: 8.5, CI: 1.3-53.6) and flap failure requiring a return to the operating room (OR: 4.5, CI: 1.5-13.2). Arterial injury did not correlate with infection or overall complication rate. In conclusion, arterial injuries resulted in significant complications for patients with lower extremity fractures requiring flap coverage, although limb salvage was still effective in most cases.

  6. Corporate corruption of the environment: sustainability as a process of compromise.

    Science.gov (United States)

    Nyberg, Daniel; Wright, Christopher

    2013-09-01

    A key response to environmental degradation, climate change and declining biodiversity has been the growing adoption of market principles in an effort to better value the social good of nature. Through concepts such as 'natural capitalism' and 'corporate environmentalism', nature is increasingly viewed as a domain of capitalist endeavour. In this article, we use convention theory and a pluralist understanding of social goods to investigate how the social good of the environment is usurped by the alternate social good of the market. Through analysis of interviews with sustainability managers and corporate documentation, we highlight how organizational actors employ compromise to temporally settle disputes between competing claims about environmental activities. Our findings contribute to an understanding of the processes of empirically grounded critique and the under-theorized concept of compromise between social goods. Rather than protecting the environment, the corporate promotion of sustainability facilitates the corruption of the social good of the environment and its conversion into a market commodity. © London School of Economics and Political Science 2013.

  7. Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells.

    Directory of Open Access Journals (Sweden)

    Zsuzsanna A Dunai

    Full Text Available For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner. Necroptosis, a type of programmed necrosis is defined as a death receptor-initiated process under caspase-compromised conditions. The process requires the kinase activity of receptor-interacting protein kinase 1 and 3 (RIPK1 and RIPK3 and mixed lineage kinase domain-like protein (MLKL, as a substrate of RIPK3. The further downstream events remain elusive. We applied known inhibitors to characterize the contributing enzymes in necroptosis and their effect on cell viability and different cellular functions were detected mainly by flow cytometry. Here we report that staurosporine, the classical inducer of intrinsic apoptotic pathway can induce necroptosis under caspase-compromised conditions in U937 cell line. This process could be hampered at least partially by the RIPK1 inhibitor necrotstin-1 and by the heat shock protein 90 kDa inhibitor geldanamycin. Moreover both the staurosporine-triggered and the classical death ligand-induced necroptotic pathway can be effectively arrested by a lysosomal enzyme inhibitor CA-074-OMe and the recently discovered MLKL inhibitor necrosulfonamide. We also confirmed that the enzymatic role of poly(ADP-ribosepolymerase (PARP is dispensable in necroptosis but it contributes to membrane disruption in secondary necrosis. In conclusion, we identified a novel way of necroptosis induction that can facilitate our understanding of the molecular mechanisms of necroptosis. Our results shed light on alternative application of staurosporine, as a possible anticancer therapeutic agent. Furthermore, we showed that the CA-074-OMe has a target in the signaling pathway leading to necroptosis. Finally, we could differentiate necroptotic and secondary necrotic processes based on participation of PARP enzyme.

  8. Safety and Efficacy of Alginate Adhesion Barrier Gel in Compromised Intestinal Anastomosis

    NARCIS (Netherlands)

    Chaturvedi, A.; Yauw, S.T.K.; Lomme, R.M.L.M.; Hendriks, T.; Goor, H. van

    2017-01-01

    BACKGROUND: For any anti-adhesive barrier developed for abdominal surgery, the use under conditions in which anastomotic healing is compromised needs to be investigated. The current study evaluates the effect of a new ultrapure alginate gel on early healing of high-risk anastomoses in the ileum and

  9. Integral Fast Reactor Program annual progress report, FY 1991

    International Nuclear Information System (INIS)

    1992-06-01

    This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1991. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R ampersand D

  10. Integral Fast Reactor Program. Annual progress report, FY 1993

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

    1994-10-01

    This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1993. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R and D.

  11. Integral Fast Reactor Program. Annual progress report, FY 1993

    International Nuclear Information System (INIS)

    Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

    1994-10-01

    This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1993. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R and D

  12. A Commentary on "Integrated Reporting: A Review of Developments and Their Implications for the Accounting Curriculum"

    Science.gov (United States)

    Kamp-Roelands, Nancy

    2013-01-01

    In this commentary, Kamp-Roelands states that it was very encouraging to observe that the Association of Chartered Certified Accountants (ACCA) recognises that responding to "Integrated Reporting" initiatives requires an "integrated approach" to accounting education. That change in financial reporting standards put pressure on…

  13. Alberta immigrant integration into the petroleum industry : final research report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-02-15

    Alberta is in the midst of a labour shortage, especially in the petroleum industry. Traditionally, the petroleum industry has secured employees by hiring them away from competitors, service providers, other geographic locations, or other industries, mostly by escalating worker compensation. However, this is no longer seen to be a sustainable solution due to higher industry costs and inflation. A good opportunity exists for Alberta's oil and gas industry to address worker demand and minimize the negative impacts associated with current and future labour concerns by increasing the participation of workers who are under-represented in the workforce, such as Aboriginals, women, and internationally trained workers. This report presented the details of a project called the Alberta immigrant integration into the petroleum industry project in order to determine the tools, resources and support processes needed by petroleum industry employers to increase the employment and retention of internationally trained workers already living in Alberta into the upstream petroleum industry. The report outlined the gaps in information, tools, resources and services that were preventing the petroleum industry from taking advantage of the skills and experience offered by Alberta's labour pool of internationally trained workers in any significant way. The report also presented an overview of strategic priorities and recommended activities, duly endorsed by stakeholders, in order to improve the recruitment and integration of internationally trained workers into the petroleum industry workforce. It was concluded that employers who develop the skills and capability to effectively recruit and integrate internationally trained workers into their workforce will have a clear advantage in the competition for skilled employees. 3 refs., 2 figs.

  14. A fuzzy compromise programming approach for the Black-Litterman portfolio selection model

    Directory of Open Access Journals (Sweden)

    Mohsen Gharakhani

    2013-01-01

    Full Text Available In this paper, we examine advanced optimization approach for portfolio problem introduced by Black and Litterman to consider the shortcomings of Markowitz standard Mean-Variance optimization. Black and Litterman propose a new approach to estimate asset return. They present a way to incorporate the investor’s views into asset pricing process. Since the investor’s view about future asset return is always subjective and imprecise, we can represent it by using fuzzy numbers and the resulting model is multi-objective linear programming. Therefore, the proposed model is analyzed through fuzzy compromise programming approach using appropriate membership function. For this purpose, we introduce the fuzzy ideal solution concept based on investor preference and indifference relationships using canonical representation of proposed fuzzy numbers by means of their correspondingα-cuts. A real world numerical example is presented in which MSCI (Morgan Stanley Capital International Index is chosen as the target index. The results are reported for a portfolio consisting of the six national indices. The performance of the proposed models is compared using several financial criteria.

  15. Integrating ergonomic knowledge into engineering design processes

    DEFF Research Database (Denmark)

    Hall-Andersen, Lene Bjerg

    Integrating ergonomic knowledge into engineering design processes has been shown to contribute to healthy and effective designs of workplaces. However, it is also well-recognized that, in practice, ergonomists often have difficulties gaining access to and impacting engineering design processes...... employed in the same company, constituted a supporting factor for the possibilities to integrate ergonomic knowledge into the engineering design processes. However, the integration activities remained discrete and only happened in some of the design projects. A major barrier was related to the business...... to the ergonomic ambitions of the clients. The ergonomists’ ability to navigate, act strategically, and compromise on ergonomic inputs is also important in relation to having an impact in the engineering design processes. Familiarity with the engineering design terminology and the setup of design projects seems...

  16. Hawaii Integrated Biofuels Research Program: Final Subcontract Report, Phase III

    Energy Technology Data Exchange (ETDEWEB)

    1992-05-01

    This report is a compilation of studies done to develop an integrated set of strategies for the production of energy from renewable resources in Hawaii. Because of the close coordination between this program and other ongoing DOE research, the work will have broad-based applicability to the entire United States.

  17. Osseous pseudo-myelomatose compromise, in leukemia chronic lymphoid

    International Nuclear Information System (INIS)

    Martinez Betancur, Octavio; Lopez de Goenaga, Maria Ines

    2000-01-01

    It was described a case of chronic lymphocytic leukemia in a 75 year old man, with pseudomyelomatosis osteolytic lesions in the skull, excluding other potential causes of osteolytic lesions in the clinical context of malignant lymphoproliferative neoplasm. The real frequency of osseous compromise in chronic lymphocytic leukemia is 10%. Lesions are defined as generalized osteoporosis and osteolysis with lacunar aspect, similar to myeloma lesions. Because histopathology in lymphoproliferative neoplasms may be similar, it might be difficult to diagnose chronic lymphocytic leukemia certainly, if the clinical manifestations are not considered. Differential diagnosis with other lymphoproliferative neoplasm is based basically in absolute lymphocytosis greater than 10 X 109/L, with lymphocytes with mature appearance

  18. Compromised Cerebral Blood Flow(CBF) in Congestive Heart Failure (CHB): non-invasive quantification with {sup 99m}Tc-ECD radionuclide angiography

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Seung; Kim, Jae Joong; Lim, Ki Chun; Lee, Hee Kyung; Moon, Dae Hyuk [Ulsan University College of Medicine, Seoul (Korea, Republic of)

    2002-07-01

    Recent reports revealed that cerebral metabolism in CHF was abnormally deranged and proposed as a potential marker of disease severity. Since deranged cerebral metabolism in CHF may result from compromised cerebral perfusion, quantification of CHF may be useful for accurate risk stratification of CHF. Therefore, we investigated whether CHF in patients with CHF is compromised and correlated with clinical parameters. Fifteen patients (M/F:11/5, 45{+-}9yr) with CHF (LVEF<40%) and 7 healthy controls (M/F:5/2, 41{+-}8yr) were prospectively studied. All patients underwent radionuclide angiography including cerebral hemispheres and aortic arch using {sup 99m}Tc-ECD. Global CBF was measured non-invasively by the application of Patlak graphical plot analysis. All patients were also evaluated using a standardized protocol that included echocardiography and clinical evaluation. Global CBF (40.3{+-}5.2 ml/min/100g) of the patients with CHF were significantly lower than those (49.7{+-}2.4 ml/min/100g) of controls (p<0.01). Global CBF were correlated with NYHA functional class (r=-0.617, p=0.43), but not correlated with other clinical parameters such as age (r=-0.463, p=0.082), duration (r=0.237, p>0.1), systolic BP (r=-0.063, p>0.5), LVEF (r=-0.13, p>0.1), LV dimension(r=0.139, p>0.5), and PV pressure gradients (r=0.072, p>0.5). Cerebral perfusion of the patients with CHF was compromised and not correlated with cardiopulmonary hemodynamic parameters.

  19. What does materiality mean to integrated reporting preparers? An empirical exploration

    OpenAIRE

    Lai, Alessandro; Melloni, Gaia; Stacchezzini, Riccardo

    2017-01-01

    Purpose—This paper seeks to understand how the principle of materiality gets implemented in integrated reporting contexts. Design/methodology/approach—Drawing on an interpretation of materiality as a social construction, this research explores the meaning that practitioners attach to the principle during their implementation of it. Following an existing framework for exploring materiality in corporate reporting, this study investigates the meaning by focusing on who participates in determinin...

  20. Integrating Neuropsychology and Brain Imaging for a Referral of Possible Pseudodementia: A Case Report.

    Science.gov (United States)

    Tanner, J J; Mellott, E; Dunne, E M; Price, C C

    2015-01-01

    The study aimed to highlight the importance of interdisciplinary collaboration and the value for combining normative neuropsychological and neuroradiological measures for clinical purposes. We present the case of "CL," a 65-year-old, right-handed, Caucasian female referred for a neuropsychological evaluation of memory difficulties and depression with the rule-out of pseudodementia. A brain magnetic resonance imaging (MRI) scan was conducted within 24 hours of the neuropsychology exam. Mood measures showed elevated depression and apathy symptoms. The neuropsychological profile showed variable effort, intact comprehension but compromised confrontation naming and verbal memory deficits. Using normative references from 20 female age- and education-matched healthy control peers, CL showed significantly reduced temporal cortex thickness with reduced bilateral hippocampal, right amygdala, and right caudate volumes. Combined data were supportive of a diagnosis of semantic dementia. Examining neuropsychological profiles in combination with neuroimaging standardized metrics relative to peers improved case conceptualization. Standard measures of effort and malingering examined alone and without MRI for the diagnosis of pseudodementia have questionable validity and rationale. We additionally discuss the advantages and limitations/challenges for integrating neuropsychological assessments with normative based MRI brain metrics.

  1. Information and analytical support of integrated reporting: evaluation of the stakeholders’ influence on the change of the created value

    Directory of Open Access Journals (Sweden)

    Yu. V. Novozhilova

    2017-01-01

    Full Text Available Information and analytical support of integrated reporting needs constant improvement, depending on the growing needs of the stakeholders. The main objective of integrated reporting is to explain how the organization creates value over time. The stakeholders play a key role in the process of value creation. Firms accumulate stakeholders’ resources and transform them, thereby meeting the needs of the parties and achieving their own goals. Building relationships with their stakeholders, organization establishes impact leverage to create value. Thus, the created value depends on the successful interaction with stakeholders. Therefore, the article is devoted to problem of information and analytical support of integrated reporting to the evaluation of created value, which is influenced by the stakeholders. The article emphasizes that an integrated quantitative measurement of value change is a complex and unresolved currently task. Integrated evaluation - a systematic analytical study, in the course of which is given summarizing evaluation of the effectiveness company. Such assessment activity is important and has a multi-purpose orientation under market conditions. The annual reports of companies are practically no integrated indicators characterizing created value. The author believes that integrated reporting should become a platform for the realization of the possibility of an integrated assessment of the created value. The results of the study are the development the methods of computation the “integrated index overall impact by the stakeholders on the company’s created value” and its testing on the example of the annual reports of the organization, which discloses information on the level of international best practice. The methodology of the research bases on such methods as analysis, synthesis, abstraction, simulation, comprehensive approach to knowledge, logical methods of research. Private indicators for the computation the

  2. CORPORATE GOVERNANCE IN THE INTEGRATED REPORTING FRAMEWORK: DISCLOSURE OF BRAZILIAN COMPANIES PARTICIPANTS IN THE PILOT PROJECT

    Directory of Open Access Journals (Sweden)

    Ana Cristina Silva Abreu

    2016-07-01

    Full Text Available This paper analyzes how Brazilian companies adhered the IIRC’s framework for integrated reporting, regarding the content element of corporate governance. The 2013 annual reporting of each company were analyzed consonants to the IIRC's framework using qualitative analysis. Categories were created for adherence of information provided by companies and applied content analysis for this purpose. Results suggest that the framework, although not being adopted integrally by the companies, was used as guide for their disclosure practices. Among other observed results for each of framework topics, BRF S.A, CPFL Energia and Itaú Unibanco disclosure practices featured as examples of adherence for the IIRC model and the inherent principles integrated in the report.

  3. International piping integrity research group (IPIRG) program final report

    International Nuclear Information System (INIS)

    Schmidt, R.; Wilkowski, G.; Scott, P.; Olsen, R.; Marschall, C.; Vieth, P.; Paul, D.

    1992-04-01

    This is the final report of the International Piping Integrity Research Group (IPIRG) Programme. The IPIRG Programme was an international group programme managed by the U.S. Nuclear Regulatory Commission and funded by a consortium of organizations from nine nations: Canada, France, Italy, Japan, Sweden, Switzerland, Taiwan, the United Kingdom, and the United states. The objective of the programme was to develop data needed to verify engineering methods for assessing the integrity of nuclear power plant piping that contains circumferential defects. The primary focus was an experimental task that investigated the behaviour of circumferentially flawed piping and piping systems to high-rate loading typical of seismic events. To accomplish these objectives a unique pipe loop test facility was designed and constructed. The pipe system was an expansion loop with over 30 m of 406-mm diameter pipe and five long radius elbows. Five experiments on flawed piping were conducted to failure in this facility with dynamic excitation. The report: provides background information on leak-before-break and flaw evaluation procedures in piping; summarizes the technical results of the programme; gives a relatively detailed assessment of the results from the various pipe fracture experiments and complementary analyses; and, summarizes the advances in the state-of-the-art of pipe fracture technology resulting from the IPIRG Program

  4. International Piping Integrity Research Group (IPIRG) Program. Final report

    International Nuclear Information System (INIS)

    Wilkowski, G.; Schmidt, R.; Scott, P.

    1997-06-01

    This is the final report of the International Piping Integrity Research Group (IPIRG) Program. The IPIRG Program was an international group program managed by the U.S. Nuclear Regulatory Commission and funded by a consortium of organizations from nine nations: Canada, France, Italy, Japan, Sweden, Switzerland, Taiwan, the United Kingdom, and the United States. The program objective was to develop data needed to verify engineering methods for assessing the integrity of circumferentially-cracked nuclear power plant piping. The primary focus was an experimental task that investigated the behavior of circumferentially flawed piping systems subjected to high-rate loadings typical of seismic events. To accomplish these objectives a pipe system fabricated as an expansion loop with over 30 meters of 16-inch diameter pipe and five long radius elbows was constructed. Five dynamic, cyclic, flawed piping experiments were conducted using this facility. This report: (1) provides background information on leak-before-break and flaw evaluation procedures for piping, (2) summarizes technical results of the program, (3) gives a relatively detailed assessment of the results from the pipe fracture experiments and complementary analyses, and (4) summarizes advances in the state-of-the-art of pipe fracture technology resulting from the IPIRG program

  5. International Piping Integrity Research Group (IPIRG) Program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Wilkowski, G.; Schmidt, R.; Scott, P. [and others

    1997-06-01

    This is the final report of the International Piping Integrity Research Group (IPIRG) Program. The IPIRG Program was an international group program managed by the U.S. Nuclear Regulatory Commission and funded by a consortium of organizations from nine nations: Canada, France, Italy, Japan, Sweden, Switzerland, Taiwan, the United Kingdom, and the United States. The program objective was to develop data needed to verify engineering methods for assessing the integrity of circumferentially-cracked nuclear power plant piping. The primary focus was an experimental task that investigated the behavior of circumferentially flawed piping systems subjected to high-rate loadings typical of seismic events. To accomplish these objectives a pipe system fabricated as an expansion loop with over 30 meters of 16-inch diameter pipe and five long radius elbows was constructed. Five dynamic, cyclic, flawed piping experiments were conducted using this facility. This report: (1) provides background information on leak-before-break and flaw evaluation procedures for piping, (2) summarizes technical results of the program, (3) gives a relatively detailed assessment of the results from the pipe fracture experiments and complementary analyses, and (4) summarizes advances in the state-of-the-art of pipe fracture technology resulting from the IPIRG program.

  6. Comment on "Compromised birth outcomes and infant mortality among racial and ethnic groups"

    NARCIS (Netherlands)

    Van der Veen, WJ

    Frisbie, Forbes, and Pullum (1996) show that it is meaningful to account for low birth weight, preterm delivery, and intrauterine growth-retardation when analyzing differences in compromised birth outcomes and infant mortality among racial and ethnic groups. I compare their findings for the 1987

  7. System Integration of Distributed Power for Complete Building Systems: Phase 2 Report

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, R.

    2003-12-01

    This report describes NiSource Energy Technologies Inc.'s second year of a planned 3-year effort to advance distributed power development, deployment, and integration. Its long-term goal is to design ways to extend distributed generation into the physical design and controls of buildings. NET worked to meet this goal through advances in the implementation and control of combined heat and power systems in end-user environments and a further understanding of electric interconnection and siting issues. The specific objective of work under this subcontract is to identify the system integration and implementation issues of DG and develop and test potential solutions to these issues. In addition, recommendations are made to resolve identified issues that may hinder or slow the integration of integrated energy systems into the national energy picture.

  8. Report of study group 4.3 ''pipeline integrity management and safety''

    Energy Technology Data Exchange (ETDEWEB)

    Clavel, P.

    2000-07-01

    This report highlights the Pipeline integrity Management methods being implemented by gas companies. These aim at maintaining the current high safety level, prevent major hazards, ensure the integrity of the pipeline and protect people and environment in the vicinity of the pipeline in the most cost effective way. It should be noticed that Pipeline Integrity Management aspects, technical and organisational, are included in the more general framework of the Safety Management System. Currently, more and more gas companies implement such a system on the basis of standards like ISO 9000 and so on. In this way, the report shows how practices of Pipeline Integrity Management are continually developing in order to adapt to their environment, and to improve performance. Past experience and imminent developments show that Pipeline Integrity Management is a flexible and efficient approach to improve safety in the long term. Consequently, Pipeline Integrity Management Systems are, under the control of authorities, the best alternative to additional safety regulations. Within the context of deregulation of the European markets and globalization Pipeline Integrity Management appears to be a tool to promote the gas industry in the eyes of the authorities, the market regulators and the customers (industrialists,...). (author)

  9. Integrated Safety and Security Risk Assessment Methods: A Survey of Key Characteristics and Applications

    NARCIS (Netherlands)

    Chockalingam, Sabarathinam; Hadziosmanovic, D.; Pieters, Wolter; Texeira, Andre; van Gelder, Pieter

    2016-01-01

    Over the last years, we have seen several security incidents that compromised system safety, of which some caused physical harm to people. Meanwhile, various risk assessment methods have been developed that integrate safety and security, and these could help to address the corresponding threats by

  10. PIMR: Parallel and Integrated Matching for Raw Data.

    Science.gov (United States)

    Li, Zhenghao; Yang, Junying; Zhao, Jiaduo; Han, Peng; Chai, Zhi

    2016-01-02

    With the trend of high-resolution imaging, computational costs of image matching have substantially increased. In order to find the compromise between accuracy and computation in real-time applications, we bring forward a fast and robust matching algorithm, named parallel and integrated matching for raw data (PIMR). This algorithm not only effectively utilizes the color information of raw data, but also designs a parallel and integrated framework to shorten the time-cost in the demosaicing stage. Experiments show that compared to existing state-of-the-art methods, the proposed algorithm yields a comparable recognition rate, while the total time-cost of imaging and matching is significantly reduced.

  11. Informatics in radiology: web-based preliminary reporting system for radiology residents with PACS integration.

    Science.gov (United States)

    O'Connell, Timothy; Chang, Debra

    2012-01-01

    While on call, radiology residents review imaging studies and issue preliminary reports to referring clinicians. In the absence of an integrated reporting system at the training sites of the authors' institution, residents were typing and faxing preliminary reports. To partially automate the on-call resident workflow, a Web-based system for resident reporting was developed by using the free open-source xAMP Web application framework and an open-source DICOM (Digital Imaging and Communications in Medicine) software toolkit, with the goals of reducing errors and lowering barriers to education. This reporting system integrates with the picture archiving and communication system to display a worklist of studies. Patient data are automatically entered in the preliminary report to prevent identification errors and simplify the report creation process. When the final report for a resident's on-call study is available, the reporting system queries the report broker for the final report, and then displays the preliminary report side by side with the final report, thus simplifying the review process and encouraging review of all of the resident's reports. The xAMP Web application framework should be considered for development of radiology department informatics projects owing to its zero cost, minimal hardware requirements, ease of programming, and large support community.

  12. Morgellons: contested illness, diagnostic compromise and medicalisation.

    Science.gov (United States)

    Fair, Brian

    2010-05-01

    The case of Morgellons illustrates how the emergence of a new medically contested illness intersected with and impacted on the diagnostic processes of an existing uncontested psychiatric condition, Delusional Parasitosis (DP). More specifically, the sociopolitical processes at play in the contested illness, Morgellons, dubiously reflect patient empowerment, as well the resilience and power of medical jurisdiction. This research offers insights into the contested illness and medicalisation literatures, and aims to bridge these two approaches towards the relationship between patient empowerment and medical authority, which I do through the notion of doctor-patient compromise. The data for this research come from a comprehensive qualitative analysis of Morgellons discourse through four key sources: the pro-Morgellons website Morgellons.org; the anti-Morgellons website Morgellonswatch.com; the popular media's portrayal of Morgellons; and the DP and Morgellons articles published in peer-reviewed medical journals, as made available on PubMed.

  13. Report of the Integrated Program Planning Activity for the DOE Fusion Energy Sciences Program

    International Nuclear Information System (INIS)

    None

    2000-01-01

    This report of the Integrated Program Planning Activity (IPPA) has been prepared in response to a recommendation by the Secretary of Energy Advisory Board that, ''Given the complex nature of the fusion effort, an integrated program planning process is an absolute necessity.'' We, therefore, undertook this activity in order to integrate the various elements of the program, to improve communication and performance accountability across the program, and to show the inter-connectedness and inter-dependency of the diverse parts of the national fusion energy sciences program. This report is based on the September 1999 Fusion Energy Sciences Advisory Committee's (FESAC) report ''Priorities and Balance within the Fusion Energy Sciences Program''. In its December 5,2000, letter to the Director of the Office of Science, the FESAC has reaffirmed the validity of the September 1999 report and stated that the IPPA presents a framework and process to guide the achievement of the 5-year goals listed in the 1999 report. The National Research Council's (NRC) Fusion Assessment Committee draft final report ''An Assessment of the Department of Energy's Office of Fusion Energy Sciences Program'', reviewing the quality of the science in the program, was made available after the IPPA report had been completed. The IPPA report is, nevertheless, consistent with the recommendations in the NRC report. In addition to program goals and the related 5-year, 10-year, and 15-year objectives, this report elaborates on the scientific issues associated with each of these objectives. The report also makes clear the relationships among the various program elements, and cites these relationships as the reason why integrated program planning is essential. In particular, while focusing on the science conducted by the program, the report addresses the important balances between the science and energy goals of the program, between the MFE and IFE approaches, and between the domestic and international aspects

  14. Addressing diversity in schools through dialogue and compromise

    DEFF Research Database (Denmark)

    Olsen, Tore Vincents

    2018-01-01

    This article evaluates a decentralized Danish model for dealing with cultural and religious diversity at individual schools. This evaluation is based upon normative theories of toleration, recognition and domination and examines whether the model implies compromise with the (liberal) educational...... values stipulated in the national legislation. The model, reconstructed from government publications, is based on reaching accommodation through dialogue between school staff and parents/students, with the pragmatic aim of facilitating the participation of students in everyday school activities....... The model is noteworthy because it appears to break with the widespread ‘retreat from multiculturalism’ predicated on the defence of liberal values, and because properly dealing with diversity at schools is important for ensuring students’ well-being and academic success....

  15. JAPC Compact Simulator evolution to latest integration

    International Nuclear Information System (INIS)

    Nabeta, T.; Nakayama, Y.

    1999-01-01

    This paper describes the evolution of JAPC compact simulator from the first installation in 1988 until recent integration with SIMULATE-3 engineering code core model and extended simulation for Mid-loop operation and severe accidents. JAPC Compact Simulator has an advanced super compact rotating panel design. Three plants, Tokai 2 (GE BWR 5), Tsuruga 1 (GE BWR 2), Tsuruga 2 (MHI PWR 4-Loop) are simulated. The simulator has been used for training of operator and engineering personnel, and has continuously been upgraded to follow normal plant modifications as well as development in modeling and computer technology. The integration of SIMULATE-3 core model is, to our knowledge, the first integration of a real design code into a training simulator. SIMULATE-3 has been successfully integrated into the simulator and run in real time, without compromising the accuracy of SIMULATE-3. The code has been modified to also handle mid-loop operation and severe accidents. (author)

  16. The diagnostic role of abdominal CT imaging findings in adults intussusception: Focused on the vascular compromise

    International Nuclear Information System (INIS)

    Park, Sung Bin; Ha, Hyun Kwon; Kim, Ah Young; Lee, Seung Soo; Kim, Hye Jin; Park, Beom Jin; Jin, Yong Hyun; Park, Seong Ho; Kim, Kyoung Won

    2007-01-01

    Intussusception is defined as telescoping of one segment of the gastrointestinal tract into an adjacent one. Unlike that in children, adult intussusception is a relatively rare condition. More than 90% of patients with adult intussusception have been reported to have an organic cause, with benign or malignant tumors for accounting for approximately 65% of the cases. In general, the diagnosis is easily made by means of computed tomography (CT) or magnetic resonance (MR) imaging. The imaging appearance of a bowel-within-bowel configuration with or without contained fat and mesenteric vessels, is pathognomonic. As the intussusceptum enters into the intussuscipiens, the mesentery is carried forward and trapped between the overlapping layers of bowel. The twisting or severe constriction of the mesenteric vessels may result in vascular compromise with subsequent edematous thickening of the involved bowel. In these circumstances, ischemic necrosis may develop if timely intervention is not undertaken. Therefore, determination of the presence or absence of intestinal necrosis in intussusception is important in patient management. On CT, the presence of well-known diagnostic CT criteria for strangulated obstruction (especially severe engorgement or twisting of the mesenteric vessels) as well as evidence of loss of the layered pattern, accumulation of extraluminal fluid collection, and bowel perforation, may suggest the diagnosis of intestinal necrosis. CT and MR imaging are limited in determining the primary disease causing intussusception. However, CT and MR provide excellent pre-operative evaluation, including the possible extension and/or dissemination of a malignant tumor. CT and MR imaging may also be useful in suggesting the presence of vascular compromise

  17. Depressive symptoms and compromised parenting in low-income mothers of infants and toddlers: distal and proximal risks.

    Science.gov (United States)

    Beeber, Linda S; Schwartz, Todd A; Martinez, Maria I; Holditch-Davis, Diane; Bledsoe, Sarah E; Canuso, Regina; Lewis, Virginia S

    2014-08-01

    Low-income mothers develop depressive symptoms at higher rates than the general population, adding to the existing risk that economic hardship places on their infants and toddlers. Emphasizing a few key intervention targets, an approach that is especially relevant to mothers when depressive symptoms compromise their energy and concentration, can improve interventions with populations facing adversity. The goal of this study was to identify contextual risk factors that significantly contributed to depressive symptoms and that, in combination with depressive symptoms, were associated with compromised parenting. Using baseline data from 251 ethnically diverse mothers from six Early Head Start programs in the Northeastern and Southeastern US, who were recruited for a clinical trial of an in-home intervention, Belsky's ecological framework of distal to proximal levels of influence was used to organize risk factors for depressive symptoms in hierarchical regression models. Under stress, mothers of toddlers reported more severe depressive symptoms than mothers of infants, supporting the need for depressive symptom screening and monitoring past the immediate postpartum period. Multivariate models revealed intervention targets that can focus depression prevention and intervention efforts, including helping mothers reduce chronic day-to-day stressors and conflicts with significant others, and to effectively handle challenging toddler behaviors, especially in the face of regional disciplinary norms. Presence of a live-in partner was linked to more effective parenting, regardless of participants' depressive symptom severity. © 2014 Wiley Periodicals, Inc.

  18. Management and design of hospital pens relative to behavior of the compromised dairy cow: A questionnaire survey of Iowa dairy farms

    DEFF Research Database (Denmark)

    Fogsgaard, Katrine Kop; Herskin, Mette S.; Gorden, Patrick J.

    2016-01-01

    on best prac-tices for housing and management of compromised cows. The purpose of this study was to providedescriptive information about management and husbandry practices of compromised cows on dairyfarms in Iowa. A questionnaire-based survey was designed to examine demographic information, designand...

  19. Does social desirability compromise self-reports of physical activity in web-based research?

    Directory of Open Access Journals (Sweden)

    Göritz Anja S

    2011-04-01

    Full Text Available Abstract Background This study investigated the relation between social desirability and self-reported physical activity in web-based research. Findings A longitudinal study (N = 5,495, 54% women was conducted on a representative sample of the Dutch population using the Marlowe-Crowne Scale as social desirability measure and the short form of the International Physical Activity Questionnaire. Social desirability was not associated with self-reported physical activity (in MET-minutes/week, nor with its sub-behaviors (i.e., walking, moderate-intensity activity, vigorous-intensity activity, and sedentary behavior. Socio-demographics (i.e., age, sex, income, and education did not moderate the effect of social desirability on self-reported physical activity and its sub-behaviors. Conclusions This study does not throw doubt on the usefulness of the Internet as a medium to collect self-reports on physical activity.

  20. Effect of reinforcement with resin composite on fracture strength of structurally compromised roots.

    Science.gov (United States)

    Fukui, Yuji; Komada, Wataru; Yoshida, Keiichi; Otake, Shiho; Okada, Daizo; Miura, Hiroyuki

    2009-09-01

    This study was aimed at evaluating the fracture resistance of structurally compromised roots restored with four different post and core systems. Thirty-two bovine roots were uniformly shaped to simulate human mandibular premolar roots. The roots were divided into four groups based on the type of restoration: cemented cast post and core (Group MC), resin composite build-up (Group CR), resin composite and prefabricated glass fiber post build-up (Group FRC), and thick-layer dual-cured resin composite-reinforced small-diameter tapered cast post and core (Group CRM). After a static loading test, the failure mode and fracture resistance were recorded. Group CRM (719.38+/-196.73 N) exhibited a significantly high fracture resistance compared with the other groups (Group MC: 429.56+/-82.43 N; Group CR: 349.56+/-66.21 N; Group FRC: 398.94+/-112.71 N; pCRM exhibited better mechanical properties for structurally compromised roots with no ferrules, although all types of restorations showed non-restorable fracture modes.

  1. A Trusted Autonomic Architecture to Safeguard Cyber-Physical Control Leaf Nodes and Protect Process Integrity

    OpenAIRE

    Chiluvuri, Nayana Teja

    2015-01-01

    Cyber-physical systems are networked through IT infrastructure and susceptible to malware. Threats targeting process control are much more safety-critical than traditional computing systems since they jeopardize the integrity of physical infrastructure. Existing defence mechanisms address security at the network nodes but do not protect the physical infrastructure if network integrity is compromised. An interface guardian architecture is implemented on cyber-physical control leaf nodes to mai...

  2. Relationship between Lower Tendency to Deceive in Aging and Inhibitory Compromise.

    Science.gov (United States)

    El Haj, Mohamad; Antoine, Pascal

    2018-01-01

    Deception can be associated with a heterogeneous network of concepts such as exaggeration, misleading, white lies, and faking. This paper assesses the tendency to deceive in aging. Our main aim was to assess whether older adults would demonstrate a low tendency to deceive. A total of 42 older adults (mean age 67.64 years, SD 7.87) and 45 younger adults (mean age 21.71 years, SD 2.66) were administered a deception scale including items such as "I sometimes tell lies if I have to" or "I never take things that don't belong to me." Participants were also administered an inhibition task. The results demonstrated a low tendency to deceive and low inhibition in older adults compared with younger ones. The low tendency to deceive in the older adults was significantly correlated with their diminished inhibitory ability. The low tendency to deceive in aging seems to be related to a difficulty in inhibiting an honest response. Since inhibitory compromise has been considered mainly to trigger negative consequences for cognition, the present paper illustrates how this age-related compromise can be associated with positive social outcomes, i.e., a low tendency to deceive. © 2017 S. Karger AG, Basel.

  3. Report Focuses on Integrity and Accessibility of Research Data

    Science.gov (United States)

    Showstack, Randy

    2009-08-01

    Rapid advances in digital technologies and enormous increases in the amount of data generated by research projects and a variety of instruments and sensors are providing new research opportunities. These advances, however, also can present challenges for ensuring that digital technologies are not used inappropriately and for managing an increasing amount of data, according to a new report issued by the U.S. National Academy of Sciences, National Academy of Engineering, and Institute of Medicine on 22 July. The new report, entitled “Ensuring the integrity, accessibility, and stewardship of research data in the digital age,” provides general principles and recommendations about the handling of research data. The report notes that the development of policies, standards, and infrastructure “is a critically important task” that will require a sustained effort from stakeholders including researchers, research institutions and sponsors, and professional societies and journals.

  4. Integrated seismic design of structure and control systems

    CERN Document Server

    Castaldo, Paolo

    2014-01-01

    The structural optimization procedure presented in this book makes it possible to achieve seismic protection through integrated structural/control system design. In particular, it is explained how slender structural systems with a high seismic performance can be achieved through inclusion of viscous and viscoelastic dampers as an integral part of the system. Readers are provided with essential introductory information on passive structural control and passive energy dissipation systems. Dynamic analyses of both single and multiple degree of freedom systems are performed in order to verify the achievement of pre-assigned performance targets, and it is explained how the optimal integrated design methodology, also relevant to retrofitting of existing buildings, should be applied. The book illustrates how structural control research is opening up new possibilities in structural forms and configurations without compromising structural performance.

  5. Subliminal food images compromise superior working memory performance in women with restricting anorexia nervosa.

    Science.gov (United States)

    Brooks, Samantha J; O'Daly, Owen G; Uher, Rudolf; Schiöth, Helgi B; Treasure, Janet; Campbell, Iain C

    2012-06-01

    Prefrontal cortex (PFC) is dysregulated in women with restricting anorexia nervosa (RAN). It is not known whether appetitive non-conscious stimuli bias cognitive responses in those with RAN. Thirteen women with RAN and 20 healthy controls (HC) completed a dorsolateral PFC (DLPFC) working memory task and an anterior cingulate cortex (ACC) conflict task, while masked subliminal food, aversive and neutral images were presented. During the DLPFC task, accuracy was higher in the RAN compared to the HC group, but superior performance was compromised when subliminal food stimuli were presented: errors positively correlated with self-reported trait anxiety in the RAN group. These effects were not observed in the ACC task. Appetitive activation is intact and anxiogenic in women with RAN, and non-consciously interacts with working memory processes associated with the DLPFC. This interaction mechanism may underlie cognitive inhibition of appetitive processes that are anxiety inducing, in people with AN. Copyright © 2012 Elsevier Inc. All rights reserved.

  6. NEMS integrating module documentation report

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-14

    The National Energy Modeling System (NEMS) is a computer modeling system that produces a general equilibrium solution for energy supply and demand in the US energy markets. The model achieves a supply and demand balance in the end-use demand regions, defined as the nine Census Divisions, by solving for the prices of each energy type such that the quantities producers are willing to supply equal the quantities consumers wish to consume. The system reflects market economics, industry structure, and energy policies and regulations that influence market behavior. The NEMS Integrating Module is the central integrating component of a complex modeling system. As such, a thorough understanding of its role in the modeling process can only be achieved by placing it in the proper context with respect to the other modules. To that end, this document provides an overview of the complete NEMS model, and includes brief descriptions of the modules with which the Integrating Module interacts. The emphasis and focus, however, is on the structure and function of the Integrating Module of NEMS.

  7. Political crisіs and compromise as the casual determinants in the process of political decisions making

    Directory of Open Access Journals (Sweden)

    Shkuro Anton Sergiyovich

    2013-12-01

    Full Text Available There is a risk of certain ineffective results in the system of political decisions making. That’s why we should pay a special attention to the criteria of political crisis evaluation. Today the problem of national politics lies only in an adequate raising of questions about the way out of the political crisis using the mechanism of compromise achieving. The article is about the fundamental role of the crisis and the compromise and about their influence on the formation of the strategic development of policy.

  8. Integral Monitored Retrievable Storage (MRS) Facility conceptual design report

    International Nuclear Information System (INIS)

    1985-09-01

    This report presents a summary design description of the Conceptual Design for an Integral Monitored Retrievable Storage (MRS) Facility, as prepared by The Ralph M. Parsons Company under an A-E services contract with the Richland Operations Office of the Department of Energy. More detailed design requirements and design data are set forth in the Basis for Design and Design Report, bound under separate cover and available for reference by those desiring such information. The design data provided in this Design Report Executive Summary, the Basis for Design, and the Design Report include contributions by the Waste Technology Services Division of Westinghouse Electric Corporation (WEC), which was responsible for the development of the waste receiving, packaging, and storage systems, and Golder Associates Incorporated (GAI), which supported the design development with program studies. The MRS Facility design requirements, which formed the basis for the design effort, were prepared by Pacific Northwest Laboratory for the US Department of Energy, Richland Operations Office, in the form of a Functional Design Criteria (FDC) document, Rev. 4, August 1985. 9 figs., 6 tabs

  9. Rapport fra to konferencer om Integrated Reporting og Integrated Thinking

    DEFF Research Database (Denmark)

    Pontoppidan, Caroline Aggestam; Sonnerfeldt, Amanda

    2017-01-01

    I løbet af de sidste to måneder af 2016, havde vi mulighed for at deltage i to konferencer, med fokus på at udvikle og fremme ‘Integrated Reporting’ (IR) og ‘Integrated Thinking’. Denne artikel søger at videregive nogle af de interessante emner og spørgsmål, der blev drøftet ved disse to begivenh......I løbet af de sidste to måneder af 2016, havde vi mulighed for at deltage i to konferencer, med fokus på at udvikle og fremme ‘Integrated Reporting’ (IR) og ‘Integrated Thinking’. Denne artikel søger at videregive nogle af de interessante emner og spørgsmål, der blev drøftet ved disse...

  10. NRC integrated program for the resolution of Unresolved Safety Issues A-3, A-4 and A-5 regarding steam generator tube integrity: Final report

    International Nuclear Information System (INIS)

    1988-09-01

    This report presents the results of the NRC integrated program for the resolution of Unresolved Safety Issues (USIs) A-3, A-4, and A-5 regarding steam generator tube integrity. A generic risk assessment is provided and indicates that risk from steam generator tube rupture (SGTR) events is not a significant contributor to total risk at a given site, nor to the total risk to which the general public is routinely exposed. This finding is considered to be indicative of the effectiveness of licensee programs and regulatory requirements for ensuring steam generator tube integrity in accordance with 10 CFR 50, Appendices A and B. This report also identifies a number of staff-recommended actions that the staff finds can further improve the effectiveness of licensee programs in ensuring the integrity of steam generator tubes and in mitigating the consequences of an SGTR. As part of the integrated program, the staff issued Generic Letter 85-02 encouraging licensees of pressurized water reactors (PWRs) to upgrade their programs, as necessary, to meet the intent of the staff-recommended actions; however, such actions do not constitute NRC requirements. In addition, this report describes a number of ongoing staff actions and studies involving steam generator issues which are being pursued to provide added assurance that risk from SGTR events will continue to be small. 146 refs., 5 figs., 11 tabs

  11. Integrated Science Assessment (ISA) for Sulfur Oxides – Health Criteria (Final Report, Sep 2008)

    Science.gov (United States)

    EPA announced the availability of the final report, Integrated Science Assessment (ISA) for Sulfur Oxides – Health Criteria final assessment. This report represents a concise synthesis and evaluation of the most policy-relevant science and will ultimately provide the scien...

  12. Integrated Data Base Program: a status report

    International Nuclear Information System (INIS)

    Notz, K.J.; Klein, J.A.

    1984-06-01

    The Integrated Data Base (IDB) Program provides official Department of Energy (DOE) data on spent fuel and radioactive waste inventories, projections, and characteristics. The accomplishments of FY 1983 are summarized for three broad areas: (1) upgrading and issuing of the annual report on spent fuel and radioactive waste inventories, projections, and characteristics, including ORIGEN2 applications and a quality assurance plan; (2) creation of a summary data file in user-friendly format for use on a personal computer and enhancing user access to program data; and (3) optimizing and documentation of the data handling methodology used by the IDB Program and providing direct support to other DOE programs and sites in data handling. Plans for future work in these three areas are outlined. 23 references, 11 figures

  13. Missouri River Scaphirhynchus albus (pallid sturgeon) effects analysis—Integrative report 2016

    Science.gov (United States)

    Jacobson, Robert B.; Annis, Mandy L.; Colvin, Michael E.; James, Daniel A.; Welker, Timothy L.; Parsley, Michael J.

    2016-07-15

    The Missouri River Pallid Sturgeon Effects Analysis was designed to carry out three components of an assessment of how Missouri River management has affected, and will affect, population dynamics of endangered Scaphirhynchus albus (pallid sturgeon): (1) collection of reliable scientific information, (2) critical assessment and synthesis of available data and analyses, and (3) analysis of the effects of actions on listed species and their habitats. This report is a synthesis of the three components emphasizing development of lines of evidence relating potential future management actions to pallid sturgeon population dynamics. We address 21 working management hypotheses that emerged from an expert opinion-based filtering process.The ability to quantify linkages from abiotic changes to pallid sturgeon population dynamics is compromised by fundamental information gaps. Although a substantial foundation of pallid sturgeon science has been developed during the past 20 years, our efforts attempt to push beyond that understanding to provide predictions of how future management actions may affect pallid sturgeon responses. For some of the 21 hypotheses, lines of evidence are limited to theoretical deduction, inference from sparse empirical datasets, or expert opinion. Useful simulation models have been developed to predict the effects of management actions on survival of drifting pallid sturgeon free embryos in the Yellowstone and Upper Missouri River complex (hereafter referred to as the “upper river”), and to assess the effects of flow and channel reconfigurations on habitat availability in the Lower Missouri River, tributaries, and Mississippi River downstream of Gavins Point Dam (hereafter referred to as the “lower river”). A population model also has been developed that can be used to assess sensitivity of the population to survival of specific life stages, assess some hypotheses related to stocking decisions, and explore a limited number of management

  14. The role of dentists on medically compromised children’s oral and dental prophylaxis in Hospital

    Directory of Open Access Journals (Sweden)

    Roosje Rosita Oewen

    2008-12-01

    Full Text Available Background: One of dentist’s main roles is to coordinate the management of medically compromised children. The term of medically compromised refers to those children who have medical conditions which affect the dental treatment or manifest as a specific oral and dental problem. Patient’s visit to Special Care for Dentistry Clinic Dr. Hasan Sadikin Hospital Bandung showed a remarkable increase. From under 10 new visit in 2003, now July–December 2008 showed 81 new visit. Purpose: This paper discusses several medical problems (cardiovascular, hematology, respiratory system, and genetic disorder in children and the role of dentist in the treatment of those patients in the hospital. Review: The increase of attention by all level to these medically compromised children in the hospital also increases the dentist’s role in supporting the prognosis of the disease and patient’s quality of life. The most important effort is oral and dental prophylaxis to prevent oral pathology which is caused by the manifestation of disease as well as the side effects of treatment. Conclusion: It is, concluded that role of the dentist in managing these patients is giving preventive efforts and dental treatment that may be improve patient’s quality of life. The preventive effort and dental treatment is customize according to the patients condition. Nevertheless, cooperation from the dentist and other professional is needed in treating these patients.

  15. Review of the integrated thermal and nonthermal treatment system studies. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    This report contains a review and evaluation of three systems analysis studies performed by LITCO on integrated thermal treatment systems and integrated nonthermal treatment systems for the remediation of mixed low-level waste stored throughout the US Department of Energy weapons complex. The review was performed by an independent team of nine researchers from the Energy and Environmental Research Center, Science Applications International Corporation, the Waste Policy Institute, and Virginia Tech. The three studies reviewed were as follows: Integrated Thermal Treatment System Study, Phase 1 -- issued July 1994; Integrated Thermal Treatment System Study, Phase 2 -- issued February 1996; and Integrated Nonthermal Treatment System Study -- drafted March 1996. The purpose of this review was to (1) determine whether the assumptions of the studies were adequate to produce an unbiased review of both thermal and nonthermal systems, (2) to identify the critical areas of the studies that would benefit from further investigation, and (3) to develop a standard template that could be used in future studies to assure a sound application of systems engineering.

  16. Review of the integrated thermal and nonthermal treatment system studies. Topical Report

    International Nuclear Information System (INIS)

    Durrani, H.A.; Schmidt, L.J.; Erickson, T.A.; Sondreal, E.A.; Erjavec, J.; Steadman, E.N.; Fabrycky, W.J.; Wilson, J.S.; Musich, M.A.

    1996-07-01

    This report analyzes three systems engineering (SE) studies performed on integrated thermal treatment systems (ITTSs) and integrated nonthermal treatment systems (INTSs) for the remediation of mixed low-level waste (MLLW) stored throughout the US Department of Energy (DOE) weapons complex. The review was performed by an independent team of nine researchers from the Energy and Environmental Research Center (EERC), Science Applications International Corporation (SAIC), the Waste Policy Institute (WPI), and Virginia Tech (VT). The three studies reviewed were as follows: Integrated Thermal Treatment System Study, Phase 1--issued July 1994; Integrated Thermal Treatment System Study, Phase 2--issued February 1996; and Integrated Nonthermal Treatment System Study--drafted March 1996. The purpose of this review was to (1) determine whether the assumptions taken in the studies might bias the resulting economic evaluations of both thermal and nonthermal systems, (2) identify the critical areas of the studies that would benefit from further investigation, and (3) develop a standard template that could be used in future studies to produce sound SE applications

  17. Review of the integrated thermal and nonthermal treatment system studies. Final report

    International Nuclear Information System (INIS)

    1996-10-01

    This report contains a review and evaluation of three systems analysis studies performed by LITCO on integrated thermal treatment systems and integrated nonthermal treatment systems for the remediation of mixed low-level waste stored throughout the US Department of Energy weapons complex. The review was performed by an independent team of nine researchers from the Energy and Environmental Research Center, Science Applications International Corporation, the Waste Policy Institute, and Virginia Tech. The three studies reviewed were as follows: Integrated Thermal Treatment System Study, Phase 1 -- issued July 1994; Integrated Thermal Treatment System Study, Phase 2 -- issued February 1996; and Integrated Nonthermal Treatment System Study -- drafted March 1996. The purpose of this review was to (1) determine whether the assumptions of the studies were adequate to produce an unbiased review of both thermal and nonthermal systems, (2) to identify the critical areas of the studies that would benefit from further investigation, and (3) to develop a standard template that could be used in future studies to assure a sound application of systems engineering

  18. Capacity for Preferences: Respecting Patients with Compromised Decision-Making.

    Science.gov (United States)

    Wasserman, Jason Adam; Navin, Mark Christopher

    2018-05-01

    When a patient lacks decision-making capacity, then according to standard clinical ethics practice in the United States, the health care team should seek guidance from a surrogate decision-maker, either previously selected by the patient or appointed by the courts. If there are no surrogates willing or able to exercise substituted judgment, then the team is to choose interventions that promote a patient's best interests. We argue that, even when there is input from a surrogate, patient preferences should be an additional source of guidance for decisions about patients who lack decision-making capacity. Our proposal builds on other efforts to help patients who lack decision-making capacity provide input into decisions about their care. For example, "supported," "assisted," or "guided" decision-making models reflect a commitment to humanistic patient engagement and create a more supportive process for patients, families, and health care teams. But often, they are supportive processes for guiding a patient toward a decision that the surrogate or team believes to be in the patient's medical best interests. Another approach holds that taking seriously the preferences of such a patient can help surrogates develop a better account of what the patient's treatment choices would have been if the patient had retained decision-making capacity; the surrogate then must try to integrate features of the patient's formerly rational self with the preferences of the patient's currently compromised self. Patients who lack decision-making capacity are well served by these efforts to solicit and use their preferences to promote best interests or to craft would-be autonomous patient images for use by surrogates. However, we go further: the moral reasons for valuing the preferences of patients without decision-making capacity are not reducible to either best-interests or (surrogate) autonomy considerations but can be grounded in the values of liberty and respect for persons. This has

  19. Steam generator tube integrity program: Phase II, Final report

    Energy Technology Data Exchange (ETDEWEB)

    Kurtz, R.J.; Bickford, R.L.; Clark, R.A.; Morris, C.J.; Simonen, F.A.; Wheeler, K.R.

    1988-08-01

    The Steam Generator Tube Integrity Program (SGTIP) was a three phase program conducted for the US Nuclear Regulatory Commission (NRC) by Pacific Northwest Laboratory (PNL). The first phase involved burst and collapse testing of typical steam generator tubing with machined defects. The second phase of the SGTIP continued the integrity testing work of Phase I, but tube specimens were degraded by chemical means rather than machining methods. The third phase of the program used a removed-from-service steam generator as a test bed for investigating the reliability and effectiveness of in-service nondestructive eddy-current inspection methods and as a source of service degraded tubes for validating the Phase I and Phase II data on tube integrity. This report describes the results of Phase II of the SGTIP. The object of this effort included burst and collapse testing of chemically defected pressurized water reactor (PWR) steam generator tubing to validate empirical equations of remaining tube integrity developed during Phase I. Three types of defect geometries were investigated: stress corrosion cracking (SCC), uniform thinning and elliptical wastage. In addition, a review of the publicly available leak rate data for steam generator tubes with axial and circumferential SCC and a comparison with an analytical leak rate model is presented. Lastly, nondestructive eddy-current (EC) measurements to determine accuracy of defect depth sizing using conventional and alternate standards is described. To supplement the laboratory EC data and obtain an estimate of EC capability to detect and size SCC, a mini-round robin test utilizing several firms that routinely perform in-service inspections was conducted.

  20. Steam generator tube integrity program: Phase II, Final report

    International Nuclear Information System (INIS)

    Kurtz, R.J.; Bickford, R.L.; Clark, R.A.; Morris, C.J.; Simonen, F.A.; Wheeler, K.R.

    1988-08-01

    The Steam Generator Tube Integrity Program (SGTIP) was a three phase program conducted for the US Nuclear Regulatory Commission (NRC) by Pacific Northwest Laboratory (PNL). The first phase involved burst and collapse testing of typical steam generator tubing with machined defects. The second phase of the SGTIP continued the integrity testing work of Phase I, but tube specimens were degraded by chemical means rather than machining methods. The third phase of the program used a removed-from-service steam generator as a test bed for investigating the reliability and effectiveness of in-service nondestructive eddy-current inspection methods and as a source of service degraded tubes for validating the Phase I and Phase II data on tube integrity. This report describes the results of Phase II of the SGTIP. The object of this effort included burst and collapse testing of chemically defected pressurized water reactor (PWR) steam generator tubing to validate empirical equations of remaining tube integrity developed during Phase I. Three types of defect geometries were investigated: stress corrosion cracking (SCC), uniform thinning and elliptical wastage. In addition, a review of the publicly available leak rate data for steam generator tubes with axial and circumferential SCC and a comparison with an analytical leak rate model is presented. Lastly, nondestructive eddy-current (EC) measurements to determine accuracy of defect depth sizing using conventional and alternate standards is described. To supplement the laboratory EC data and obtain an estimate of EC capability to detect and size SCC, a mini-round robin test utilizing several firms that routinely perform in-service inspections was conducted

  1. Study of flood defense structural measures priorities using Compromise Programming technique

    Science.gov (United States)

    Lim, D.; Jeong, S.

    2017-12-01

    Recent climate change of global warming has led to the frequent occurrence of heavy regional rainfalls. As such, inundation vulnerability increases in urban areas with high population density due to the low runoff carrying capacity. This study selects a sample area (Janghang-eup, the Republic of Korea), which is one of the most vulnerable areas to flooding, analyzing the urban flood runoff model (XP-SWMM) and using the MCDM (Multi-Criteria Decision Making) technique to establish flood protection structural measures. To this end, we compare the alternatives and choose the optimal flood defense measure: our model is utilized with three flood prevention structural measures; (i) drainage pipe construction; (ii) water detention; and (iii) flood pumping station. Dividing the target area into three small basins, we propose flood evaluations for an inundation decrease by studying the flooded area, the maximum inundation depth, the damaged residential area, and the construction cost. In addition, Compromise Programming determines the priority of the alternatives. As a consequent, this study suggests flood pumping station for Zone 1 and drainage pipe construction for Zone 2 and Zone 3, respectively, as the optimal flood defense alternative. Keywords : MCDM; Compromise Programming; Urban Flood Prevention; This research was supported by a grant [MPSS-DP-2013-62] through the Disaster and Safety Management Institute funded by Ministry of Public Safety and Security of Korean government.

  2. Chronic implantation of cuff electrodes on the pelvic nerve in rats is well tolerated and does not compromise afferent or efferent fibre functionality

    Science.gov (United States)

    Crook, J. J.; Brouillard, C. B. J.; Irazoqui, P. P.; Lovick, T. A.

    2018-04-01

    Objective. Neuromodulation of autonomic nerve activity to regulate physiological processes is an emerging field. Vagal stimulation has received most attention whereas the potential of modulate visceral function by targeting autonomic nerves within the abdominal cavity remains under-exploited. Surgery to locate intra-abdominal targets is inherently more stressful than for peripheral nerves. Electrode leads risk becoming entrapped by intestines and loss of functionality in the nerve-target organ connection could result from electrode migration or twisting. Since nociceptor afferents are intermingled with similar-sized visceral autonomic fibres, stimulation may induce pain. In anaesthetised rats high frequency stimulation of the pelvic nerve can suppress urinary voiding but it is not known how conscious animals would react to this procedure. Our objective therefore was to determine how rats tolerated chronic implantation of cuff electrodes on the pelvic nerve, whether nerve stimulation would be aversive and whether nerve-bladder functionality would be compromised. Approach. We carried out a preliminary de-risking study to investigate how conscious rats tolerated chronic implantation of electrodes on the pelvic nerve, their responsiveness to intermittent high frequency stimulation and whether functionality of the nerve-bladder connection became compromised. Main results. Implantation of cuff electrodes was well-tolerated. The normal diurnal pattern of urinary voiding was not disrupted. Pelvic nerve stimulation (up to 4 mA, 3 kHz) for 30 min periods evoked mild alerting at stimulus onset but no signs of pain. Stimulation evoked a modest (nerve temperature but the functional integrity of the nerve-bladder connection, reflected by contraction of the detrusor muscle in response to 10 Hz nerve stimulation, was not compromised. Significance. Chronic implantation of cuff electrodes on the pelvic nerve was found to be a well-tolerated procedure in rats and high frequency

  3. The Swiss approach to finding compromises in nuclear waste governance

    Energy Technology Data Exchange (ETDEWEB)

    Kuppler, Sophie; Grunwald, Armin [Karlsruhe Institute of Technology (Germany). Inst. for Technology Assessment and Systems Analysis

    2015-07-01

    In Switzerland, a new site selection procedure is being implemented since 2008. This procedure, which is laid down in a 'sectoral plan', shows strong elements of public participation and transparency and can be considered a step away from the classical 'decide-announce-defend' approach in decision-making. This procedure tends towards a more governance-oriented approach based on ideas of 'civility' of decision-making. Despite this renewal, the Swiss case clearly shows that any kind of selection process has to be considered as a 'working compromise', which needs to be adapted when new challenges emerge.

  4. The Swiss approach to finding compromises in nuclear waste governance

    International Nuclear Information System (INIS)

    Kuppler, Sophie; Grunwald, Armin

    2015-01-01

    In Switzerland, a new site selection procedure is being implemented since 2008. This procedure, which is laid down in a 'sectoral plan', shows strong elements of public participation and transparency and can be considered a step away from the classical 'decide-announce-defend' approach in decision-making. This procedure tends towards a more governance-oriented approach based on ideas of 'civility' of decision-making. Despite this renewal, the Swiss case clearly shows that any kind of selection process has to be considered as a 'working compromise', which needs to be adapted when new challenges emerge.

  5. Integrated Reporting and Assurance of Sustainability Information: An Experimental Study on Professional Investors’ Information Processing

    NARCIS (Netherlands)

    Reimsbach, D.; Hahn, R.; Gürtürk, A.

    2018-01-01

    Sustainability-related non-financial information is increasingly deemed value relevant. Against this background, two recent trends in non-financial reporting are frequently discussed: integrated reporting and assurance of sustainability information. Using an established framework of information

  6. Understanding Youth's Health-Compromising Behaviors in Germany: An Application of the Risk-Behavior Framework.

    Science.gov (United States)

    Hazard, Barbara P.; Lee, Che-Fu

    1999-01-01

    Analyzed the health-compromising behaviors of German youth using responses of 2,330 seventh, eighth, and ninth graders from the German Youth Study. Smoking and drinking are not seen by these students as health-threatening behaviors, but as socially appealing behaviors. Discusses implications for health education. (SLD)

  7. Resale Price Maintenance Under the Hong Kong Competition Ordinance—An Uneasy Compromise

    OpenAIRE

    Mark Jephcott; Adelaide Luke; Lisa Geary; Molly Herron

    2015-01-01

    However, the compromise position reached in the Guideline provides relatively little in terms of legal certainty as to the circumstances in which RPM may be acceptable. Mark Jephcott, Adelaide Luke, Lisa Geary, & Molly Herron (Herbert Smith Freehills)

  8. A monitor for the laboratory evaluation of control integrity in digital control systems operating in harsh electromagnetic environments

    Science.gov (United States)

    Belcastro, Celeste M.; Fischl, Robert; Kam, Moshe

    1992-01-01

    This paper presents a strategy for dynamically monitoring digital controllers in the laboratory for susceptibility to electromagnetic disturbances that compromise control integrity. The integrity of digital control systems operating in harsh electromagnetic environments can be compromised by upsets caused by induced transient electrical signals. Digital system upset is a functional error mode that involves no component damage, can occur simultaneously in all channels of a redundant control computer, and is software dependent. The motivation for this work is the need to develop tools and techniques that can be used in the laboratory to validate and/or certify critical aircraft controllers operating in electromagnetically adverse environments that result from lightning, high-intensity radiated fields (HIRF), and nuclear electromagnetic pulses (NEMP). The detection strategy presented in this paper provides dynamic monitoring of a given control computer for degraded functional integrity resulting from redundancy management errors, control calculation errors, and control correctness/effectiveness errors. In particular, this paper discusses the use of Kalman filtering, data fusion, and statistical decision theory in monitoring a given digital controller for control calculation errors.

  9. U.S. Department of Energy integrated manufacturing & processing predoctoral fellowships. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Petrochenkov, Margaret

    2003-03-31

    The objective of this program was threefold: to create a pool of PhDs trained in the integrated approach to manufacturing and processing, to promote academic interest in the field, and to attract talented professionals to this challenging area of engineering. It was anticipated that the program would result in the creation of new manufacturing methods that would contribute to improved energy efficiency, to better utilization of scarce resources, and to less degradation of the environment. Emphasis in the competition was on integrated systems of manufacturing and the integration of product design with manufacturing processes. Research addressed such related areas as aspects of unit operations, tooling and equipment, intelligent sensors, and manufacturing systems as they related to product design. This is the final report to close out the contract.

  10. KEY PERFORMANCE INDICATORS. A CASE STUDY ON THE INTEGRATED REPORTS OF AN IT COMPANY

    Directory of Open Access Journals (Sweden)

    GORGAN CĂTĂLINA

    2014-06-01

    Full Text Available Our analysis relies on the 2011 integrated report published by SAP, a European IT company included in the International Integrated Reporting Committee (IIRC Pilot Programme Business Network. The research methodology used is the analysis of the content as we search for a number of selected characteristics in the report and also for a set of key performance indicators (KPI. We use as references the guide provided by DVFA (Society of Investment Professionals in Germany and EFFAS (European Federation of Financial Analysts Societies – EFFAS (2010 for the software industry. The aim of our study is to analyse the way in which an IT company applies the guidelines recognised by the European Commission to identify and communicate the material nonfinancial information, in order to assess the organization’s abilities to create value on a short, medium and long term.

  11. Monolithic microwave integrated circuits: Interconnections and packaging considerations

    Science.gov (United States)

    Bhasin, K. B.; Downey, A. N.; Ponchak, G. E.; Romanofsky, R. R.; Anzic, G.; Connolly, D. J.

    1984-01-01

    Monolithic microwave integrated circuits (MMIC's) above 18 GHz were developed because of important potential system benefits in cost reliability, reproducibility, and control of circuit parameters. The importance of interconnection and packaging techniques that do not compromise these MMIC virtues is emphasized. Currently available microwave transmission media are evaluated to determine their suitability for MMIC interconnections. An antipodal finline type of microstrip waveguide transition's performance is presented. Packaging requirements for MMIC's are discussed for thermal, mechanical, and electrical parameters for optimum desired performance.

  12. Monolithic microwave integrated circuits: Interconnections and packaging considerations

    Science.gov (United States)

    Bhasin, K. B.; Downey, A. N.; Ponchak, G. E.; Romanofsky, R. R.; Anzic, G.; Connolly, D. J.

    Monolithic microwave integrated circuits (MMIC's) above 18 GHz were developed because of important potential system benefits in cost reliability, reproducibility, and control of circuit parameters. The importance of interconnection and packaging techniques that do not compromise these MMIC virtues is emphasized. Currently available microwave transmission media are evaluated to determine their suitability for MMIC interconnections. An antipodal finline type of microstrip waveguide transition's performance is presented. Packaging requirements for MMIC's are discussed for thermal, mechanical, and electrical parameters for optimum desired performance.

  13. Naturkraft integration at Kaarstoe. Mapping study report 6 march 2009

    Energy Technology Data Exchange (ETDEWEB)

    Odland, Oeystein; Hoeie, Hans; Aanestad, Per; Hauge, Bjoern I.; Solvang, Svein; Boee, Stein Espen; Lervik, Steinar; Kristiansen, Arild

    2007-07-01

    Gassco is engaged in three different studies and projects related to reduce CO{sub 2} emissions at Kaarstoe; 1. Gassnova's CO{sub 2} capture, transport and storage projects at Kaarstoe and Mongstad (the CO{sub 2} Transportation Network), where Gassco role is to mature the transportation facilities of the project. An investment decision is planned for second half of 2009. 2. The Kaarstoe Flue Gas Capture pre-feasibility study initiated by the MPE to Gassco as operator of Gassled in connection with approval of the Kaarstoe Expansion Project 2010, to evaluate the potential of capturing the CO{sub 2} emissions at the Kaarstoe gas processing plant, and reported to the MPE 3 March 2009, and 3. This Naturkraft Integration Mapping Study initiated by MPE to meet the requirements set out by the letter to Gassco dated 3 December 2008 to evaluate possibilities to integrate existing Naturkraft's power plant with the Kaarstoe gas processing plant. In this Naturkraft Integration Study report Gassco has identified potential degrees of integration and resulting impact with respect to performance of both the Naturkraft power plant and the Kaarstoe gas processing plant. A major concern related to operations of the Kaarstoe gas processing plant is the regularity and availability issues related to natural gas and NGL export. The value of the petroleum transported over Kaarstoe on any day exceeds 200 million NOK. In addition also significant oil production will be shut down if the Kaarstoe gas processing plant is not operating. Hence the regularity of energy supply including steam is of utmost importance. The integration between Naturkraft and the gas processing plant is based on supplying energy (i.e. fuel gas, steam, heat and electricity) from Naturkraft's existing power plant, and therefore must be based on predictable and steady operations of the Naturkraft power plant. Naturkraft has only been in operation for a few weeks from the start-up of the power plant 1

  14. Integral Monitored Retrievable Storage (MRS) Facility conceptual design report

    International Nuclear Information System (INIS)

    1985-09-01

    The Basis for Design established the functional requirements and design criteria for an Integral Monitored Retrievable Storage (MRS) facility. The MRS Facility design, described in this report, is based on those requirements and includes all infrastructure, facilities, and equipment required to routinely receive, unload, prepare for storage, and store spent fuel (SF), high-level waste (HLW), and transuranic waste (TRU), and to decontaminate and return shipping casks received by both rail and truck. The facility is complete with all supporting facilities to make the MRS Facility a self-sufficient installation

  15. Conflicting perspectives compromising discussions on cardiopulmonary resuscitation.

    LENUS (Irish Health Repository)

    Groarke, J

    2010-09-01

    Healthcare professionals, patients and their relatives are expected to discuss resuscitation together. This study aims to identify the differences in the knowledge base and understanding of these parties. Questionnaires examining knowledge and opinion on resuscitation matters were completed during interviews of randomly selected doctors, nurses and the general public. 70% doctors, 24% nurses and 0% of a public group correctly estimated survival to discharge following in-hospital resuscitation attempts. Deficiencies were identified in doctor and nurse knowledge of ethics governing resuscitation decisions. Public opinion often conflicts with ethical guidelines. Public understanding of the nature of cardiopulmonary arrests and resuscitation attempts; and of the implications of a \\'Do Not Attempt Resuscitation (DNAR)\\' order is poor. Television medical dramas are the primary source of resuscitation knowledge. Deficiencies in healthcare professionals\\' knowledge of resuscitation ethics and outcomes may compromise resuscitation decisions. Educational initiatives to address deficiencies are necessary. Parties involved in discussion on resuscitation do not share the same knowledge base reducing the likelihood of meaningful discussion. Public misapprehensions surrounding resuscitation must be identified and corrected during discussion.

  16. 76 FR 17843 - Intent To Compromise Claim Against the District of Columbia Public Schools

    Science.gov (United States)

    2011-03-31

    ... District of Columbia Public Schools (DCPS) now pending before the Office of Administrative Law Judges (OALJ... DEPARTMENT OF EDUCATION Intent To Compromise Claim Against the District of Columbia Public Schools... Application for Review of this PDL with the Office of Administrative Law Judges (OALJ) on September 10, 2007...

  17. Low-Cost Solar Array Project. Progress report 12, January-April 1979 and proceedings of the 12th Project Integration Meeting

    Energy Technology Data Exchange (ETDEWEB)

    1979-01-01

    This report describes progress made by the Low-Cost Solar Array Project during the period January through April 1979. It includes reports on project analysis and integration; technology development in silicon material, large-area sheet silicon, and encapsulation; production process and equipment development; engineering and operations, and a discussion of the steps taken to integrate these efforts. It includes a report on, and copies of viewgraphs presented at the Project Integration Meeting held April 4-5, 1979.

  18. Small intestine epithelial barrier function is compromised in pigs with low feed intake at weaning.

    NARCIS (Netherlands)

    Spreeuwenberg, M.A.; Verdonk, J.M.; Gaskins, H.R.; Verstegen, M.W.A.

    2001-01-01

    Compromising alterations in gastrointestinal architecture are common during the weaning transition of pigs. The relation between villous atrophy and epithelial barrier function at weaning is not well understood. This study evaluated in vitro transepithelial transport by Ussing metabolic chambers,

  19. Integrated care: an Information Model for Patient Safety and Vigilance Reporting Systems.

    Science.gov (United States)

    Rodrigues, Jean-Marie; Schulz, Stefan; Souvignet, Julien

    2015-01-01

    Quality management information systems for safety as a whole or for specific vigilances share the same information types but are not interoperable. An international initiative tries to develop an integrated information model for patient safety and vigilance reporting to support a global approach of heath care quality.

  20. Heat stress and reduced plane of nutrition decreases intestinal integrity and function in pigs.

    Science.gov (United States)

    Pearce, S C; Mani, V; Weber, T E; Rhoads, R P; Patience, J F; Baumgard, L H; Gabler, N K

    2013-11-01

    Heat stress can compromise intestinal integrity and induce leaky gut in a variety of species. Therefore, the objectives of this study were to determine if heat stress (HS) directly or indirectly (via reduced feed intake) increases intestinal permeability in growing pigs. We hypothesized that an increased heat-load causes physiological alterations to the intestinal epithelium, resulting in compromised barrier integrity and altered intestinal function that contributes to the overall severity of HS-related illness. Crossbred gilts (n=48, 43±4 kg BW) were housed in constant climate controlled rooms in individual pens and exposed to 1) thermal neutral (TN) conditions (20°C, 35-50% humidity) with ad libitum intake, 2) HS conditions (35°C, 20-35% humidity) with ad libitum feed intake, or 3) pair-fed in TN conditions (PFTN) to eliminate confounding effects of dissimilar feed intake. Pigs were sacrificed at 1, 3, or 7 d of environmental exposure and jejunum samples were mounted into modified Ussing chambers for assessment of transepithelial electrical resistance (TER) and intestinal fluorescein isothiocyanate (FITC)-labeled lipopolysaccharide (LPS) permeability (expressed as apparent permeability coefficient, APP). Further, gene and protein markers of intestinal integrity and stress were assessed. Irrespective of d of HS exposure, plasma endotoxin levels increased 45% (Pwarm summer months.

  1. 1998 interim 242-A Evaporator tank system integrity assessment report

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, C.E.

    1998-07-02

    This Integrity Assessment Report (IAR) is prepared by Fluor Daniel Northwest (FDNW) under contract to Lockheed-Martin Hanford Company (LMHC) for Waste Management Hanford (WMH), the 242-A Evaporator (facility) operations contractor for Fluor Daniel Hanford, and the US Department of Energy, the system owner. The contract specifies that FDNW perform an interim (5 year) integrity assessment of the facility and prepare a written IAR in accordance with Washington Administrative Code (WAC) 173-303-640. The WAC 173-303 defines a treatment, storage, or disposal (TSD) facility tank system as the ``dangerous waste storage or treatment tank and its ancillary equipment and containment.`` This integrity assessment evaluates the two tank systems at the facility: the evaporator vessel, C-A-1 (also called the vapor-liquid separator), and the condensate collection tank, TK-C-100. This IAR evaluates the 242-A facility tank systems up to, but not including, the last valve or flanged connection inside the facility perimeter. The initial integrity assessment performed on the facility evaluated certain subsystems not directly in contact with dangerous waste, such as the steam condensate and used raw water subsystems, to provide technical information. These subsystems were not evaluated in this IAR. The last major upgrade to the facility was project B-534. The facility modifications, as a result of project B-534, were evaluated in the 1993 facility interim integrity assessment. Since that time, the following upgrades have occurred in the facility: installation of a process condensate recycle system, and installation of a package steam boiler to provide steam for the facility. The package boiler is not within the scope of the facility TSD.

  2. 1998 interim 242-A Evaporator tank system integrity assessment report

    International Nuclear Information System (INIS)

    Jensen, C.E.

    1998-01-01

    This Integrity Assessment Report (IAR) is prepared by Fluor Daniel Northwest (FDNW) under contract to Lockheed-Martin Hanford Company (LMHC) for Waste Management Hanford (WMH), the 242-A Evaporator (facility) operations contractor for Fluor Daniel Hanford, and the US Department of Energy, the system owner. The contract specifies that FDNW perform an interim (5 year) integrity assessment of the facility and prepare a written IAR in accordance with Washington Administrative Code (WAC) 173-303-640. The WAC 173-303 defines a treatment, storage, or disposal (TSD) facility tank system as the ''dangerous waste storage or treatment tank and its ancillary equipment and containment.'' This integrity assessment evaluates the two tank systems at the facility: the evaporator vessel, C-A-1 (also called the vapor-liquid separator), and the condensate collection tank, TK-C-100. This IAR evaluates the 242-A facility tank systems up to, but not including, the last valve or flanged connection inside the facility perimeter. The initial integrity assessment performed on the facility evaluated certain subsystems not directly in contact with dangerous waste, such as the steam condensate and used raw water subsystems, to provide technical information. These subsystems were not evaluated in this IAR. The last major upgrade to the facility was project B-534. The facility modifications, as a result of project B-534, were evaluated in the 1993 facility interim integrity assessment. Since that time, the following upgrades have occurred in the facility: installation of a process condensate recycle system, and installation of a package steam boiler to provide steam for the facility. The package boiler is not within the scope of the facility TSD

  3. Integrated Site Model Process Model Report

    International Nuclear Information System (INIS)

    Booth, T.

    2000-01-01

    The Integrated Site Model (ISM) provides a framework for discussing the geologic features and properties of Yucca Mountain, which is being evaluated as a potential site for a geologic repository for the disposal of nuclear waste. The ISM is important to the evaluation of the site because it provides 3-D portrayals of site geologic, rock property, and mineralogic characteristics and their spatial variabilities. The ISM is not a single discrete model; rather, it is a set of static representations that provide three-dimensional (3-D), computer representations of site geology, selected hydrologic and rock properties, and mineralogic-characteristics data. These representations are manifested in three separate model components of the ISM: the Geologic Framework Model (GFM), the Rock Properties Model (RPM), and the Mineralogic Model (MM). The GFM provides a representation of the 3-D stratigraphy and geologic structure. Based on the framework provided by the GFM, the RPM and MM provide spatial simulations of the rock and hydrologic properties, and mineralogy, respectively. Functional summaries of the component models and their respective output are provided in Section 1.4. Each of the component models of the ISM considers different specific aspects of the site geologic setting. Each model was developed using unique methodologies and inputs, and the determination of the modeled units for each of the components is dependent on the requirements of that component. Therefore, while the ISM represents the integration of the rock properties and mineralogy into a geologic framework, the discussion of ISM construction and results is most appropriately presented in terms of the three separate components. This Process Model Report (PMR) summarizes the individual component models of the ISM (the GFM, RPM, and MM) and describes how the three components are constructed and combined to form the ISM

  4. Design of energy efficient optical networks with software enabled integrated control plane

    DEFF Research Database (Denmark)

    Wang, Jiayuan; Yan, Ying; Dittmann, Lars

    2015-01-01

    energy consumption by proposing a new integrated control plane structure utilising Software Defined Networking technologies. The integrated control plane increases the efficiencies of exchanging control information across different network domains, while introducing new possibilities to the routing...... methods and the control over quality of service (QoS). The structure is defined as an overlay generalised multi-protocol label switching (GMPLS) control model. With the defined structure, the integrated control plane is able to gather information from different domains (i.e. optical core network......'s) routing behaviours. With the flexibility of the routing structure, results show that the energy efficiency of the network can be improved without compromising the QoS for delay/blocking sensitive services....

  5. Advanced medical life support procedures in vitally compromised children by a helicopter emergency medical service.

    NARCIS (Netherlands)

    Gerritse, B.M.; Schalkwijk, A.; Pelzer, B.J.; Scheffer, G.J.; Draaisma, J.M.T.

    2010-01-01

    BACKGROUND: To determine the advanced life support procedures provided by an Emergency Medical Service (EMS) and a Helicopter Emergency Medical Service (HEMS) for vitally compromised children. Incidence and success rate of several procedures were studied, with a distinction made between procedures

  6. Community for Data Integration 2014 annual report

    Science.gov (United States)

    Langseth, Madison L.; Chang, Michelle Y.; Carlino, Jennifer; Birch, Daniella D.; Bradley, Joshua; Bristol, R. Sky; Conzelmann, Craig; Diehl, Robert H.; Earle, Paul S.; Ellison, Laura E.; Everette, Anthony L.; Fuller, Pamela L.; Gordon, Janice M.; Govoni, David L.; Guy, Michelle R.; Henkel, Heather S.; Hutchison, Vivian B.; Kern, Tim; Lightsom, Frances L.; Long, Joseph W.; Longhenry, Ryan; Preston, Todd M.; Smith, Stan W.; Viger, Roland J.; Wesenberg, Katherine; Wood, Eric C.

    2015-10-02

    The U.S. Geological Survey (USGS) researches Earth science to help address complex issues affecting society and the environment. In 2006, the USGS held the first Scientific Information Management Workshop to bring together staff from across the organization to discuss the data and information management issues affecting the integration and delivery of Earth science research and investigate the use of “communities of practice” as mechanisms to share expertise about these issues. Out of this effort emerged the Council for Data Integration, which was conceived as an official organizational function that would help guide data integration activities and formalize communities of practice into working groups; however, by 2009 it became evident that many members of the Council for Data Integration had an interest in developing data integration solutions and sharing expertise in a less formal, grassroots manner, which transformed the Council into a Community for Data Integration (CDI). As of 2014, the CDI represents a dynamic community of practice focused on advancing science data and information management and integration capabilities across the USGS and the CDI community.

  7. 28 CFR 0.163 - Approval by Solicitor General of action on compromise offers in certain cases.

    Science.gov (United States)

    2010-07-01

    ... advice from the Solicitor General that the principles of law involved do not require appellate review in... JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Authority To Compromise and Close Civil Claims and...

  8. Contribution of Regional White Matter Integrity to Visuospatial Construction Accuracy, Organizational Strategy, and Memory for a Complex Figure in Abstinent Alcoholics.

    Science.gov (United States)

    Rosenbloom, Margaret J; Sassoon, Stephanie A; Pfefferbaum, Adolf; Sullivan, Edith V

    2009-12-01

    Visuospatial construction ability as used in drawing complex figures is commonly impaired in chronic alcoholics, but memory for such information can be enhanced by use of a holistic drawing strategy during encoding. We administered the Rey-Osterrieth Complex Figure Test (ROCFT) to 41 alcoholic and 38 control men and women and assessed the contribution of diffusion tensor imaging (DTI) measures of integrity of selected white matter tracts to ROCFT copy accuracy, copy strategy, and recall accuracy. Although alcoholics copied the figure less accurately than controls, a more holistic strategy at copy was associated with better recall in both groups. Greater radial diffusivity, reflecting compromised myelin integrity, in occipital forceps and external capsule was associated with poorer copy accuracy in both groups. Lower FA, reflecting compromised fiber microstructure in the inferior cingulate bundle, which links frontal and medial temporal episodic memory systems, was associated with piecemeal copy strategy and poorer immediate recall in the alcoholics. The correlations were generally modest and should be considered exploratory. To the extent that the inferior cingulate was relatively spared in alcoholics, it may have provided an alternative pathway to the compromised frontal system for successful copy strategy and, by extension, aided recall.

  9. Corporate Disclosure, Materiality, and Integrated Report: An Event Study Analysis

    Directory of Open Access Journals (Sweden)

    Maria Cleofe Giorgino

    2017-11-01

    Full Text Available Within the extensive literature investigating the impacts of corporate disclosure in supporting the sustainable growth of an organization, few studies have included in the analysis the materiality issue referred to the information being disclosed. This article aims to address this gap, exploring the effect produced on capital markets by the publication of a recent corporate reporting tool, Integrated Report (IR. The features of this tool are that it aims to represent the multidimensional impact of the organization’s activity and assumes materiality as a guiding principle of the report drafting. Adopting the event study methodology associated with a statistical significance test for categorical data, our results verify that an organization’s release of IR is able to produce a statistically significant impact on the related share prices. Moreover, the term “integrated” assigned to the reports plays a significant role in the impact on capital markets. Our findings have beneficial implications for both researchers and practitioners, adding new evidence for the IR usefulness as a corporate disclosure tool and the effect of an organization’s decision to disclose material information.

  10. Integrated Transport Planning Framework Involving Combined Utility Regret Approach

    DEFF Research Database (Denmark)

    Wang, Yang; Monzon, Andres; Di Ciommo, Floridea

    2014-01-01

    Sustainable transport planning requires an integrated approach involving strategic planning, impact analysis, and multicriteria evaluation. This study aimed at relaxing the utility-based decision-making assumption by newly embedding anticipated-regret and combined utility regret decision mechanisms...... in a framework for integrated transport planning. The framework consisted of a two-round Delphi survey, integrated land use and transport model for Madrid, and multicriteria analysis. Results show that (a) the regret-based ranking has a similar mean but larger variance than the utility-based ranking does, (b......) the least-regret scenario forms a compromise between the desired and the expected scenarios, (c) the least-regret scenario can lead to higher user benefits in the short term and lower user benefits in the long term, (d) the utility-based, the regret-based, and the combined utility- and regret...

  11. A Pirate too Needs to be Heard: Procedural Compromises in Online Copyright Infringement Cases in the UK

    Directory of Open Access Journals (Sweden)

    Poorna Mysoor

    2014-08-01

    Full Text Available Online copyright infringement is one of the toughest challenges the content industry has faced in the twenty first century. Article 8(3 of the Information Society Directive, implemented under section 97A of the UK Copyright, Designs and Patents Act, 1988, provides an injunctive remedy in response to such online infringement. Given the elusive nature of the website operators and the sheer number of their users, rights owners have turned to the Internet Service Providers (ISPs to implement the injunctions granted under section 97A to block websites with infringing content. In their battle to keep pace with online infringers, the UK courts have permitted significant compromises to the procedures while granting these injunctive blocking orders. One of the pioneers in this line of cases in the UK is the Pirate Bay case (TPB case, which ruled as a matter of law that the procedure under Section 97A does not require the alleged infringers to be made parties to those proceedings. TPB case also marks the trend of the ISPs consenting to an order of injunction, and not defending the proceedings. This has resulted in the absence of any adverse party in the proceedings under section 97A. This threatens the basic tenets of procedural fairness and propriety, having adverse consequences on both the substantive and procedural aspects, evident in the cases that followed TPB case. This article examines the aspects of the judgment in TPB case that led to these procedural compromises, whether it had any basis in the pre-existing case law, what the nature of an injunction under section 97A is and how the subsequent line of cases have followed TPB case as a precedent. It further explores the adverse consequences of the procedural compromises and whether any safeguards are available against such compromises.

  12. The effect of dietary adaption on cranial morphological integration in capuchins (order Primates, genus Cebus.

    Directory of Open Access Journals (Sweden)

    Jana Makedonska

    Full Text Available A fundamental challenge of morphology is to identify the underlying evolutionary and developmental mechanisms leading to correlated phenotypic characters. Patterns and magnitudes of morphological integration and their association with environmental variables are essential for understanding the evolution of complex phenotypes, yet the nature of the relevant selective pressures remains poorly understood. In this study, the adaptive significance of morphological integration was evaluated through the association between feeding mechanics, ingestive behavior and craniofacial variation. Five capuchin species were examined, Cebus apella sensu stricto, Cebus libidinosus, Cebus nigritus, Cebus olivaceus and Cebus albifrons. Twenty three-dimensional landmarks were chosen to sample facial regions experiencing high strains during feeding, characteristics affecting muscular mechanical advantage and basicranial regions. Integration structure and magnitude between and within the oral and zygomatic subunits, between and within blocks maximizing modularity and within the face, the basicranium and the cranium were examined using partial-least squares, eigenvalue variance, integration indices compared inter-specifically at a common level of sampled population variance and cluster analyses. Results are consistent with previous findings reporting a relative constancy of facial and cranial correlation patterns across mammals, while covariance magnitudes vary. Results further suggest that food material properties structure integration among functionally-linked facial elements and possibly integration between the face and the basicranium. Hard-object-feeding capuchins, especially C. apella s.s., whose faces experience particularly high biomechanical loads are characterized by higher facial and cranial integration especially compared to C. albifrons, likely because morphotypes compromising feeding performance are selected against in species relying on obdurate fallback

  13. Hydro-environmental management of groundwater resources: A fuzzy-based multi-objective compromise approach

    Science.gov (United States)

    Alizadeh, Mohammad Reza; Nikoo, Mohammad Reza; Rakhshandehroo, Gholam Reza

    2017-08-01

    Sustainable management of water resources necessitates close attention to social, economic and environmental aspects such as water quality and quantity concerns and potential conflicts. This study presents a new fuzzy-based multi-objective compromise methodology to determine the socio-optimal and sustainable policies for hydro-environmental management of groundwater resources, which simultaneously considers the conflicts and negotiation of involved stakeholders, uncertainties in decision makers' preferences, existing uncertainties in the groundwater parameters and groundwater quality and quantity issues. The fuzzy multi-objective simulation-optimization model is developed based on qualitative and quantitative groundwater simulation model (MODFLOW and MT3D), multi-objective optimization model (NSGA-II), Monte Carlo analysis and Fuzzy Transformation Method (FTM). Best compromise solutions (best management policies) on trade-off curves are determined using four different Fuzzy Social Choice (FSC) methods. Finally, a unanimity fallback bargaining method is utilized to suggest the most preferred FSC method. Kavar-Maharloo aquifer system in Fars, Iran, as a typical multi-stakeholder multi-objective real-world problem is considered to verify the proposed methodology. Results showed an effective performance of the framework for determining the most sustainable allocation policy in groundwater resource management.

  14. Location Does Not Have to Be Destiny: Student Evaluation and Integrity Controls in a Management Accounting Class

    Science.gov (United States)

    Goldwater, Paul M.; Fogarty, Timothy J.

    2012-01-01

    As accounting education transitions to more distance-learning formats, the integrity of student evaluation continues to serve as an obstacle to adoption. Greater technological possibilities will be opposed if faculty members believe that testing is compromised. This article investigates whether students taking exams remotely (and under no…

  15. Integration of metabolome data with metabolic networks reveals reporter reactions

    DEFF Research Database (Denmark)

    Çakir, Tunahan; Patil, Kiran Raosaheb; Önsan, Zeynep Ilsen

    2006-01-01

    Interpreting quantitative metabolome data is a difficult task owing to the high connectivity in metabolic networks and inherent interdependency between enzymatic regulation, metabolite levels and fluxes. Here we present a hypothesis-driven algorithm for the integration of such data with metabolic...... network topology. The algorithm thus enables identification of reporter reactions, which are reactions where there are significant coordinated changes in the level of surrounding metabolites following environmental/genetic perturbations. Applicability of the algorithm is demonstrated by using data from...... is measured. By combining the results with transcriptome data, we further show that it is possible to infer whether the reactions are hierarchically or metabolically regulated. Hereby, the reported approach represents an attempt to map different layers of regulation within metabolic networks through...

  16. November 2016 West Hackberry Subsidence Report

    Energy Technology Data Exchange (ETDEWEB)

    Moriarty, Dylan Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lord, Anna C. Snider [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-02-01

    Subsidence monitoring is a critical component to understanding the cavern integrity of salt storage caverns. This report looks at historical and recent data from two of the three West Hackberry dome cavern operators. DOE SPR and LA Storage are coordinating subsidence surveys to create a comprehensive understanding of ground movement above the dome. Data from annual level and rod surveys, GPS, and tiltmeter data show the sites are experiencing typical ground movement. The highest subsidence rate is seen in the middle of the DOE SPR site at just under one inch per year with less ground movement around the edge of the site. A GPS and tiltmeter instrument in the northeast areas of the DOE SPR site has not seen any trend change since the devices were installed in 2013. Comparison between recent ground movement data and historical trends suggest that there is no reason to believe that any DOE SPR or LA Storage caverns have been structurally compromised.

  17. Buried waste integrated demonstration Fiscal Year 1993 close-out report

    International Nuclear Information System (INIS)

    Owens, K.J.; Hyde, R.A.

    1994-04-01

    The Buried Waste Integrated Demonstration (BWID) supports the applied research, development, demonstration, and evaluation of a multitude of advanced technologies. These technologies are being integrated to form a comprehensive remediation system for the effective and efficient remediation of buried waste. These efforts are identified and coordinated in support of the U.S. Department of Energy Environmental Restoration and Waste Management needs and objectives. BWID works with universities and private industry to develop these technologies, which are being transferred to the private sector for use nationally and internationally. A public participation policy has been established to provide stakeholders with timely and accurate information and meaningful opportunities for involvement in the technology development and demonstration process. To accomplish this mission of identifying technological solutions for remediation deficiencies, the Office of Technology Development initiated BWID at the Idaho National Engineering Laboratory. This report summarizes the activities of the BWID program during FY-93

  18. Low plasma cortisol and fecal cortisol metabolite measures as indicators of compromised welfare in domestic horses (Equus caballus.

    Directory of Open Access Journals (Sweden)

    Jodi Pawluski

    Full Text Available The hypothalamic-pituitary-adrenal (HPA axis response to chronic stress is far from straight forward, particularly with regards to animal welfare. There are reports of no effect as well as both decreases and increases in cortisol after chronic stressors. Therefore, the first aim of the present study was to determine how measures of compromised welfare, such as chronic pain and haematological anomalies, related to cortisol levels in domestic horses (Equus caballus. Domestic horses are an informative model to investigate the impact of chronic stress (due to environment, pain, work, housing conditions… on the HPA axis. The second aim was to determine whether levels of fecal cortisol metabolites (FCM may be used as an indicator of welfare measures. The present study used fifty-nine horses (44 geldings and 15 mares, from three riding centres in Brittany, France. The primary findings show that horses whose welfare was clearly compromised (as indicated by an unusual ears backward position, presence of vertebral problems or haematological anomalies, e.g. anaemia also had lower levels of both FCM and plasma cortisol. This work extends our previous findings showing that withdrawn postures, indicators of depressive-like behavior in horses, are associated with lower plasma cortisol levels. We also found that evening plasma cortisol levels positively correlated with FCM levels in horses. Future research aims to determine the extent to which factors of influence on welfare, such as living conditions (e.g. single stalls versus group housing in pasture or paddocks, early life factors, and human interaction, act as mediators of cortisol levels in horses.

  19. Integrated approach towards the application of horizontal wells to improve waterflooding performance. Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Kelkar, M.; Liner, C.; Kerr, D.

    1995-05-01

    This annual report describes the progress during the second year of the project on Integrated Approach Towards the Application of Horizontal Wells to Improve Waterflooding Performance. This project is funded under the Department of Energy`s Class I program which is targeted towards improving the reservoir performance of mature oil fields located in fluvial-dominated deltaic deposits. The project involves an integrated approach to characterize the reservoir followed by the drilling of horizontal injection wells to improve production performance. The type of data we have integrated include cross bore hole seismic surveys, geological interpretation based on logs and cores, and engineering information. This report covers the second phase of the project which includes a detailed reservoir description of the field by integrating all the available information, followed by flow simulation of the Self Unit under various operating conditions. Based on an examination of the various operating parameters, we observed that the best possible solution to improve the Self Unit performance is to recomplete and stimulate most of the wells followed by an increase in the water injection rate. Drilling of horizontal injection well, although helpful in improving the performance, was not found to be economically feasible. The proposed reservoir management plan will be implemented shortly.

  20. Clustering of health-compromising behavior and delinquency in adolescents and adults in the Dutch population

    NARCIS (Netherlands)

    van Nieuwenhuijzen, Maroesjka; Junger, Marianne; Klein Velderman, Mariska; Wiefferink, Karin H.; Paulussen, Theo W. G. M.; Hox, Joop; Reijneveld, Sijmen A.

    Objective. This study investigates the clustering of a broad range of health-compromising and delinquent behaviors. We examine whether these behaviors belong to a single but broad cluster. 'risk-taking behavior', and whether the nature and degree of clustering in adolescents differs from that in

  1. How to Integrate HIV and Sexual and Reproductive Health Services in Namibia, the Epako Clinic Case Study

    Directory of Open Access Journals (Sweden)

    Tomas Zapata

    2017-07-01

    Full Text Available Introduction: During the past two decades, HIV and Sexual and Reproductive Health services in Namibia have been provided in silos, with high fragmentation. As a consequence of this, quality and efficiency of services in Primary Health Care has been compromised.  Methods: We conducted an operational research (observational pre-post study in a public health facility in Namibia. A health facility assessment was conducted before and after the integration of health services. A person-centred integrated model was implemented to integrate all health services provided at the health facility in addition to HIV and Sexual and Reproductive Health services. Comprehensive services are provided by each health worker to the same patients over time (longitudinality, on a daily basis (accessibility and with a good external referral system (coordination. Prevalence rates of time flows and productivity were done.  Results: Integrated services improved accessibility, stigma and quality of antenatal care services by improving the provider-patient communication, reducing the time that patients stay in the clinic in 16% and reducing the waiting times in 14%. In addition, nurse productivity improved 85% and the expected time in the health facility was reduced 24% without compromising the uptake of TB, HIV, outpatient, antenatal care or first visit family planning services. Given the success on many indicators resulting from integration of services, the goal of this paper was to describe “how” health services have been integrated, the “process” followed and presenting some “results” from the integrated clinic.  Conclusions: Our study shows that HIV and SRH services can be effectively integrated by following the person-centred integrated model. Based on the Namibian experience on “how” to integrate health services and the “process” to achieve it, other African countries can replicate the model to move away from the silo approach and contribute to

  2. Body integrity identity disorder: deranged body processing, right fronto-parietal dysfunction, and phenomenological experience of body incongruity.

    Science.gov (United States)

    Giummarra, Melita J; Bradshaw, John L; Nicholls, Michael E R; Hilti, Leonie M; Brugger, Peter

    2011-12-01

    Body integrity identity disorder (BIID) is characterised by profound experience of incongruity between the biological and desired body structure. The condition manifests in "non-belonging" of body parts, and the subsequent desire to amputate, paralyse or disable a limb. Little is known about BIID; however, a neuropsychological model implicating right fronto-parietal and insular networks is emerging, with potential disruption to body representation. We argue that, as there is scant systematic research on BIID published to date and much of the research is methodologically weak, it is premature to assume that the only process underlying bodily experience that is compromised is body representation. The present review systematically investigates which aspects of neurological processing of the body, and sense of self, may be compromised in BIID. We argue that the disorder most likely reflects dysregulation in multiple levels of body processing. That is, the disunity between self and the body could arguably come about through congenital and/or developmental disruption of body representations, which, together with altered multisensory integration, may preclude the experience of self-attribution and embodiment of affected body parts. Ulimately, there is a need for official diagnostic criteria to facilitate epidemiological characterisation of BIID, and for further research to systematically investigate which aspects of body representation and processing are truly compromised in the disorder.

  3. DefenseLink.mil - Special Report - Military Integration

    Science.gov (United States)

    Commemorates 60 Years Of Armed Forces Integration WASHINGTON, Aug. 6, 2008 – Marking the 60th anniversary of the integration of the armed services is a reminder of "how far we've come toward living up to , Aug. 6, 2008 - As the Defense Department commemorated 60 years of integration, President Harry S

  4. Towards mesoscience the principle of compromise in competition

    CERN Document Server

    Li, Jinghai

    2014-01-01

    This brief is devoted to providing a complete outline of meso-science by briefing the relevant contents from the published book and by updating evidences and concepts of meso-science. The importance of meso-science in solving various problems in energy, resource, and the environment is introduced.  The whole evolutionary development of the EMMS principle is reviewed to show how a simple idea on the customized modeling of particle clustering in gas-solid systems was developed, verified, extended, and finally generalized into the common principle of compromise in competition between dominant mechanisms for all mesoscale phenomena in science and engineering, leading to the proposition of meso-science. More importantly, updates on the concept of meso-science and perspectives are presented, along with new insights and findings from after the publication of the original book. In this way, we hope to help readers more easily familiarize themselves with meso-science, and to trigger interest and attention to this int...

  5. Data And Informatics Working Group On Virtual Data Integration Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    Williams, D. N. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Palanisamy, G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dam, K. K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-10-13

    This report is the outcome of a workshop that was commissioned by the Department of Energy’s Climate and Environmental Sciences Division (CESD) to examine current and future data infrastructure requirements that would be foundational to achieving CESD’s scientific mission goals. Over the past several years, data volumes in CESD disciplines have risen sharply to unprecedented levels (tens of petabytes). So too has the complexity and diversity of the research data (simulation, observation, and reanalysis) needing to be captured, stored, verified, analyzed, and integrated. With the trends of increased data volume (in the hundreds of petabytes), more complex analysis processes, and growing crossdisciplinary collaborations, it is timely to investigate whether the CESD community has the right computational and data support to realize the full scientific potential from its data collections. In recognition of the challenges, a partnership is forming across CESD and with national and international agencies to investigate the viability of creating an integrated, collaborative data infrastructure: a virtual laboratory. The overarching goal of this report is to identify the community’s key data technology requirements and high-priority development needs for sustaining and growing their scientific discovery potential. The report also aims to map these requirements to existing solutions and to identify gaps in current services, tools, and infrastructure that will need to be addressed in the short, medium, and long term so as not to impede scientific progress

  6. Annual Report of the Integrated Status and Effectiveness Monitoring Program: Fiscal Year 2008

    Energy Technology Data Exchange (ETDEWEB)

    Terraqua, Inc. (Wauconda, WA)

    2009-07-20

    This document was created as an annual report detailing the accomplishments of the Integrated Status and Effectiveness Monitoring Program (ISEMP) in the Upper Columbia Basin in fiscal year 2008. The report consists of sub-chapters that reflect the various components of the program. Chapter 1 presents a report on programmatic coordination and accomplishments, and Chapters 2 through 4 provide a review of how ISEMP has progressed during the 2008 fiscal year in each of the pilot project subbasins: the John Day (Chapter 2), Wenatchee/Entiat (Chapter 3) and Salmon River (Chapter 4). Chapter 5 presents a report on the data management accomplishments in 2008.

  7. The Role of Technical Advances in the Adoption and Integration of Patient-Reported Outcomes in Clinical Care

    Science.gov (United States)

    Jensen, Roxanne E.; Rothrock, Nan E.; DeWitt, Esi Morgan; Spiegel, Brennan; Tucker, Carole A.; Crane, Heidi M.; Forrest, Christopher B.; Patrick, Donald L.; Fredericksen, Rob; Shulman, Lisa M.; Cella, David; Crane, Paul K.

    2016-01-01

    Background Patient-reported outcomes (PROs) are gaining recognition as key measures for improving the quality of patient care in clinical care settings. Three factors have made the implementation of PROs in clinical care more feasible: increased use of modern measurement methods in PRO design and validation, rapid progression of technology (e.g., touch screen tablets, Internet accessibility, and electronic health records (EHRs)), and greater demand for measurement and monitoring of PROs by regulators, payers, accreditors, and professional organizations. As electronic PRO collection and reporting capabilities have improved, the challenges of collecting PRO data have changed. Objectives To update information on PRO adoption considerations in clinical care, highlighting electronic and technical advances with respect to measure selection, clinical workflow, data infrastructure, and outcomes reporting. Methods Five practical case studies across diverse healthcare settings and patient populations are used to explore how implementation barriers were addressed to promote the successful integration of PRO collection into the clinical workflow. The case studies address selecting and reporting of relevant content, workflow integration, pre-visit screening, effective evaluation, and EHR integration. Conclusions These case studies exemplify elements of well-designed electronic systems, including response automation, tailoring of item selection and reporting algorithms, flexibility of collection location, and integration with patient health care data elements. They also highlight emerging logistical barriers in this area, such as the need for specialized technological and methodological expertise, and design limitations of current electronic data capture systems. PMID:25588135

  8. Community for Data Integration 2013 Annual Report

    Science.gov (United States)

    Chang, Michelle Y.; Carlino, Jennifer; Barnes, Christopher; Blodgett, David L.; Bock, Andrew R.; Everette, Anthony L.; Fernette, Gregory L.; Flint, Lorraine E.; Gordon, Janice M.; Govoni, David L.; Hay, Lauren E.; Henkel, Heather S.; Hines, Megan K.; Holl, Sally L.; Homer, Collin G.; Hutchison, Vivian B.; Ignizio, Drew A.; Kern, Tim J.; Lightsom, Frances L.; Markstrom, Steven L.; O'Donnell, Michael S.; Schei, Jacquelyn L.; Schmid, Lorna A.; Schoephoester, Kathryn M.; Schweitzer, Peter N.; Skagen, Susan K.; Sullivan, Daniel J.; Talbert, Colin; Warren, Meredith Pavlick

    2015-01-01

    The U.S. Geological Survey (USGS) conducts earth science to help address complex issues affecting society and the environment. In 2006, the USGS held the first Scientific Information Management Workshop to bring together staff from across the organization to discuss the data and information management issues affecting the integration and delivery of earth science research and investigate the use of “communities of practice” as mechanisms to share expertise about these issues. Out of this effort emerged the Council for Data Integration, which was conceived as an official organizational function that would help guide data integration activities and formalize communities of practice into working groups. However by 2009, it became apparent that many members of the council had an interest in developing data integration solutions and sharing expertise in a less formal grassroots perspective, thus transforming the “Council” into a “Community” for Data Integration (CDI). Today, the CDI represents a dynamic community of practice focused on advancing science data and information management and integration capabilities across the USGS and the CDI community.

  9. Building "Nuestra América:" national sovereignty and regional integration in the americas

    Directory of Open Access Journals (Sweden)

    Renata Keller

    2013-12-01

    Full Text Available This article explores the history of regional integration in the Americas, drawing lessons from the diverse ways that people have sought to unite the hemisphere. It begins at the point when most of the modern nation-states of Latin America came into being: the nineteenth-century wars for independence. From there, it traces various attempts at regional integration, keeping in mind three fundamental questions: How does regional integration compromise sovereignty? Does it have to? Is it worth sacrificing sovereignty to increase integration? The article concludes that while every attempt at regional integration in the Americas has required the participants to voluntarily sacrifice some measure of their sovereignty, the most successful efforts have been those that either kept the sacrifice to a minimum or offered significant enough rewards to offset the loss of sovereignty.

  10. Isolated adrenal paracoccidioidomycosis: Case report

    International Nuclear Information System (INIS)

    Uribe Castro, Jorge Ricardo; Quintana, Humberto; Puentes, Alix Sofia and others

    2011-01-01

    Even though paracoccidioidomycosis has a relatively high prevalence in Latin America in a systemic form, isolated cases, especially compromising the adrenal glands, are uncommon, with only two reported cases. In this article, we report the case of a 55 year-old male with clinical manifestations of adrenal insufficiency. The only imaging finding was the presence of bilateral adrenal masses. The biopsy showed Paracoccidioides brasiliensis infection.

  11. Quantum dash based single section mode locked lasers for photonic integrated circuits.

    Science.gov (United States)

    Joshi, Siddharth; Calò, Cosimo; Chimot, Nicolas; Radziunas, Mindaugas; Arkhipov, Rostislav; Barbet, Sophie; Accard, Alain; Ramdane, Abderrahim; Lelarge, Francois

    2014-05-05

    We present the first demonstration of an InAs/InP Quantum Dash based single-section frequency comb generator designed for use in photonic integrated circuits (PICs). The laser cavity is closed using a specifically designed Bragg reflector without compromising the mode-locking performance of the self pulsating laser. This enables the integration of single-section mode-locked laser in photonic integrated circuits as on-chip frequency comb generators. We also investigate the relations between cavity modes in such a device and demonstrate how the dispersion of the complex mode frequencies induced by the Bragg grating implies a violation of the equi-distance between the adjacent mode frequencies and, therefore, forbids the locking of the modes in a classical Bragg Device. Finally we integrate such a Bragg Mirror based laser with Semiconductor Optical Amplifier (SOA) to demonstrate the monolithic integration of QDash based low phase noise sources in PICs.

  12. 'Compromise position' image alignment to accommodate independent motion of multiple clinical target volumes during radiotherapy: A high risk prostate cancer example.

    Science.gov (United States)

    Rosewall, Tara; Yan, Jing; Alasti, Hamideh; Cerase, Carla; Bayley, Andrew

    2017-04-01

    Inclusion of multiple independently moving clinical target volumes (CTVs) in the irradiated volume causes an image guidance conundrum. The purpose of this research was to use high risk prostate cancer as a clinical example to evaluate a 'compromise' image alignment strategy. The daily pre-treatment orthogonal EPI for 14 consecutive patients were included in this analysis. Image matching was performed by aligning to the prostate only, the bony pelvis only and using the 'compromise' strategy. Residual CTV surrogate displacements were quantified for each of the alignment strategies. Analysis of the 388 daily fractions indicated surrogate displacements were well-correlated in all directions (r 2  = 0.95 (LR), 0.67 (AP) and 0.59 (SI). Differences between the surrogates displacements (95% range) were -0.4 to 1.8 mm (LR), -1.2 to 5.2 mm (SI) and -1.2 to 5.2 mm (AP). The distribution of the residual displacements was significantly smaller using the 'compromise' strategy, compared to the other strategies (p 0.005). The 'compromise' strategy ensured the CTV was encompassed by the PTV in all fractions, compared to 47 PTV violations when aligned to prostate only. This study demonstrated the feasibility of a compromise position image guidance strategy to accommodate simultaneous displacements of two independently moving CTVs. Application of this strategy was facilitated by correlation between the CTV displacements and resulted in no geometric excursions of the CTVs beyond standard sized PTVs. This simple image guidance strategy may also be applicable to other disease sites that concurrently irradiate multiple CTVs, such as head and neck, lung and cervix cancer. © 2016 The Royal Australian and New Zealand College of Radiologists.

  13. Buried Waste Integrated Demonstration fiscal Year 1994 close-out report

    International Nuclear Information System (INIS)

    Owen, K.J.

    1995-07-01

    The Buried Waste integrated Demonstration (BWID) supports the applied research, development, demonstration, and evaluation of a multitude of advanced technologies. These technologies are being integrated to form a comprehensive remediation system for the effective and efficient remediation of buried waste. These efforts are identified and coordinated in support of the US Department of Energy Environmental Restoration and Waste Management needs and objectives. BWID works with universities and private industry to develop these technologies, which are being transferred to the private sector for use nationally and internationally. A public participation policy has been established to provide stakeholders with timely and accurate information and meaningful opportunities for involvement in the technology development and demonstration process. To accomplish this mission of identifying technological solutions for remediation deficiencies, the Department of Energy Office of Technology Development initiated BMD at the Idaho National Engineering Laboratory. This report summarizes the activities of the BWID program during Fiscal Year 1994. In Fiscal Year 1995, these activities are transitioning into the Landfill Stabilization Focus Area

  14. Quarterly Report 11 for the Period October 1978 - December 1978 and Proceedings of the 11th Project Integration Meeting

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-10-01

    This report describes progress made by the Low-Cost Solar Array Project during the period October through December 1978. It includes task reports on silicon material processing, large-area silicon sheet development, encapsulation mate3rials testing and development, Project engineering and operations, and manufacturing techniques, plus the steps taken to integrate these efforts. it also includes a report on and copies of viewgraphs presented at the Project Integration Meeting held December 13-14, 1978.

  15. Transient inhibition of cell proliferation does not compromise self-renewal of mouse embryonic stem cells

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Ruoxing [Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406 (United States); Guo, Yan-Lin, E-mail: yanlin.guo@usm.edu [Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406 (United States)

    2012-10-01

    Embryonic stem cells (ESCs) have unlimited capacity for self-renewal and can differentiate into various cell types when induced. They also have an unusual cell cycle control mechanism driven by constitutively active cyclin dependent kinases (Cdks). In mouse ESCs (mESCs). It is proposed that the rapid cell proliferation could be a necessary part of mechanisms that maintain mESC self-renewal and pluripotency, but this hypothesis is not in line with the finding in human ESCs (hESCs) that the length of the cell cycle is similar to differentiated cells. Therefore, whether rapid cell proliferation is essential for the maintenance of mESC state remains unclear. We provide insight into this uncertainty through chemical intervention of mESC cell cycle. We report here that inhibition of Cdks with olomoucine II can dramatically slow down cell proliferation of mESCs with concurrent down-regulation of cyclin A, B and E, and the activation of the Rb pathway. However, mESCs display can recover upon the removal of olomoucine II and are able to resume normal cell proliferation without losing self-renewal and pluripotency, as demonstrated by the expression of ESC markers, colony formation, embryoid body formation, and induced differentiation. We provide a mechanistic explanation for these observations by demonstrating that Oct4 and Nanog, two major transcription factors that play critical roles in the maintenance of ESC properties, are up-regulated via de novo protein synthesis when the cells are exposed to olomoucine II. Together, our data suggest that short-term inhibition of cell proliferation does not compromise the basic properties of mESCs. -- Highlights: Black-Right-Pointing-Pointer Inhibition of Cdks slows down mESCs proliferation. Black-Right-Pointing-Pointer mESCs display remarkable recovery capacity from short-term cell cycle interruption. Black-Right-Pointing-Pointer Short-term cell cycle interruption does not compromise mESC self-renewal. Black

  16. Transient inhibition of cell proliferation does not compromise self-renewal of mouse embryonic stem cells

    International Nuclear Information System (INIS)

    Wang, Ruoxing; Guo, Yan-Lin

    2012-01-01

    Embryonic stem cells (ESCs) have unlimited capacity for self-renewal and can differentiate into various cell types when induced. They also have an unusual cell cycle control mechanism driven by constitutively active cyclin dependent kinases (Cdks). In mouse ESCs (mESCs). It is proposed that the rapid cell proliferation could be a necessary part of mechanisms that maintain mESC self-renewal and pluripotency, but this hypothesis is not in line with the finding in human ESCs (hESCs) that the length of the cell cycle is similar to differentiated cells. Therefore, whether rapid cell proliferation is essential for the maintenance of mESC state remains unclear. We provide insight into this uncertainty through chemical intervention of mESC cell cycle. We report here that inhibition of Cdks with olomoucine II can dramatically slow down cell proliferation of mESCs with concurrent down-regulation of cyclin A, B and E, and the activation of the Rb pathway. However, mESCs display can recover upon the removal of olomoucine II and are able to resume normal cell proliferation without losing self-renewal and pluripotency, as demonstrated by the expression of ESC markers, colony formation, embryoid body formation, and induced differentiation. We provide a mechanistic explanation for these observations by demonstrating that Oct4 and Nanog, two major transcription factors that play critical roles in the maintenance of ESC properties, are up-regulated via de novo protein synthesis when the cells are exposed to olomoucine II. Together, our data suggest that short-term inhibition of cell proliferation does not compromise the basic properties of mESCs. -- Highlights: ► Inhibition of Cdks slows down mESCs proliferation. ► mESCs display remarkable recovery capacity from short-term cell cycle interruption. ► Short-term cell cycle interruption does not compromise mESC self-renewal. ► Oct4 and Nanog are up-regulated via de novo synthesis by cell cycle interruption.

  17. Dealing with surplus emissions in the climate negotiations after Copenhagen: What are the options for compromise?

    International Nuclear Information System (INIS)

    Elzen, Michel den; Roelfsema, Mark; Slingerland, Stephan

    2010-01-01

    This paper analyses the environmental and financial consequences of various strategies of dealing with surplus emission allowances in the aftermath of the Copenhagen Accord. This topic remains relevant, in particular, with respect to the Russian negotiation position, as this country is the largest holder of surplus emissions. It is concluded that not addressing the surplus problem is not a feasible negotiation option, as the sheer size of the surpluses would jeopardise the environmental integrity of any future agreement. Cancelling surpluses against Russia's will, though viable, is not desirable, as it might well lead to this country opting out of this climate treaty. Three options for compromise have been selected and analysed here: (1) stricter targets for Annex I countries; (2) strategic reserve for Russia; (3) institutionalising optimal banking. It is concluded that, whereas option 1 is environmentally the best, in the present political context it is probably less feasible. The other two options, although environmentally suboptimal, seem politically more favourable. Our analysis suggests that maximal revenues for surplus-holding countries arise by releasing only a limited amount of surplus credits to the market. The institutionalisation of this effect could be a key lever to a politically feasible agreement on surplus emissions.

  18. The Immediate Aesthetic and Functional Restoration of Maxillary Incisors Compromised by Periodontitis Using Short Implants with Single Crown Restorations: A Minimally Invasive Approach and Five-Year Follow-Up

    Directory of Open Access Journals (Sweden)

    Mauro Marincola

    2015-01-01

    Full Text Available The functional and aesthetic restoration of teeth compromised due to aggressive periodontitis presents numerous challenges for the clinician. Horizontal bone loss and soft tissue destruction resulting from periodontitis can impede implant placement and the regeneration of an aesthetically pleasing gingival smile line, often requiring bone augmentation and mucogingival surgery, respectively. Conservative approaches to the treatment of aggressive periodontitis (i.e., treatments that use minimally invasive tools and techniques have been purported to yield positive outcomes. Here, we report on the treatment and five-year follow-up of patient suffering from aggressive periodontitis using a minimally invasive surgical technique and implant system. By using the methods described herein, we were able to achieve the immediate aesthetic and functional restoration of the maxillary incisors in a case that would otherwise require bone augmentation and extensive mucogingival surgery. This technique represents a conservative and efficacious alternative to the aesthetic and functional replacement of teeth compromised due to aggressive periodontitis.

  19. White Matter Microstructural Compromise Is Associated With Cognition But Not Posttraumatic Stress Disorder Symptoms in Military Veterans With Traumatic Brain Injury.

    Science.gov (United States)

    Sorg, Scott F; Schiehser, Dawn M; Bondi, Mark W; Luc, Norman; Clark, Alexandra L; Jacobson, Mark W; Frank, Lawrence R; Delano-Wood, Lisa

    2016-01-01

    To investigate white matter microstructure compromise in Veterans with a history of traumatic brain injury (TBI) and its possible contribution to posttraumatic stress disorder (PTSD) symptomatology and neuropsychological functioning via diffusion tensor imaging. Thirty-eight Veterans with mild (n = 33) and moderate (n = 5) TBI and 17 military control participants without TBI completed neuropsychological testing and psychiatric screening and underwent magnetic resonance imaging an average of 4 years following their TBI event(s). Fractional anisotropy (FA) and diffusivity measures were extracted from 9 white matter tracts. Compared with military control participants, TBI participants reported higher levels of PTSD symptoms and performed worse on measures of memory and psychomotor-processing speed. Traumatic brain injury was associated with lower FA in the genu of the corpus callosum and left cingulum bundle. Fractional anisotropy negatively correlated with processing speed and/or executive functions in 7 of the 8 tracts. Regional FA did not correlate with memory or PTSD symptom ratings. Results suggest that current PTSD symptoms are independent of TBI-related white matter alterations, as measured by diffusion tensor imaging. In addition, white matter microstructural compromise may contribute to reduced processing speed in our sample of participants with history of neurotrauma. Findings of the current study add insight into the factors associated with complicated recovery from mild to moderate TBI.

  20. Compromises produced by the dialectic between self-verification and self-enhancement.

    Science.gov (United States)

    Morling, B; Epstein, S

    1997-12-01

    Three studies of people's reactions to evaluative feedback demonstrated that the dialectic between self-enhancement and self-verification results in compromises between these 2 motives, as hypothesized in cognitive-experiential self-theory. The demonstration was facilitated by 2 procedural improvements: Enhancement and verification were established by calibrating evaluative feedback against self appraisals, and degree of enhancement and of verification were varied along a continuum, rather than categorically. There was also support for the hypotheses that processing in an intuitive-experiential mode favors enhancement and processing in an analytical-rational mode favors verification in the kinds of situations investigated.

  1. Externe verslaggeving How do current public Integrated Reports align with the IR Framework?

    NARCIS (Netherlands)

    Hurks, P.; Langendijk, H.P.A.J.; Nandram, K.

    2016-01-01

    This paper examines empirically the current practice with regard to integrated reporting according to the IR Framework among the 104 original participants (companies) of the IIRC Pilot program. We made a selection with respect to these 104 participants based on organization’s stipulation that they

  2. Wind integration in Alberta

    International Nuclear Information System (INIS)

    Frost, W.

    2007-01-01

    This presentation described the role of the Alberta Electric System Operator (AESO) for Alberta's interconnected electric system with particular reference to wind integration in Alberta. The challenges of wind integration were discussed along with the requirements for implementing the market and operational framework. The AESO is an independent system operator that directs the reliable operation of Alberta's power grid; develops and operates Alberta's real-time wholesale energy market to promote open competition; plans and develops the province's transmission system to ensure reliability; and provides transmission system access for both generation and load customers. Alberta has over 280 power generating station, with a total generating capacity of 11,742 MW, of which 443 is wind generated. Since 2004, the AESO has been working with industry on wind integration issues, such as operating limits, need for mitigation measures and market rules. In April 2006, the AESO implemented a temporary 900 MW reliability threshold to ensure reliability. In 2006, a Wind Forecasting Working Group was created in collaboration with industry and the Canadian Wind Energy Association in an effort to integrate as much wind as is feasible without compromising the system reliability or the competitive operation of the market. The challenges facing wind integration include reliability issues; predictability of wind power; the need for dispatchable generation; transmission upgrades; and, defining a market and operational framework for the large wind potential in Alberta. It was noted that 1400 MW of installed wind energy capacity can be accommodated in Alberta with approved transmission upgrades. figs

  3. Dynamic Reactive Power Compensation of Large Scale Wind Integrated Power System

    DEFF Research Database (Denmark)

    Rather, Zakir Hussain; Chen, Zhe; Thøgersen, Paul

    2015-01-01

    wind turbines especially wind farms with additional grid support functionalities like dynamic support (e,g dynamic reactive power support etc.) and ii) refurbishment of existing conventional central power plants to synchronous condensers could be one of the efficient, reliable and cost effective option......Due to progressive displacement of conventional power plants by wind turbines, dynamic security of large scale wind integrated power systems gets significantly compromised. In this paper we first highlight the importance of dynamic reactive power support/voltage security in large scale wind...... integrated power systems with least presence of conventional power plants. Then we propose a mixed integer dynamic optimization based method for optimal dynamic reactive power allocation in large scale wind integrated power systems. One of the important aspects of the proposed methodology is that unlike...

  4. 7 CFR 3.12 - Reporting of consumer debts.

    Science.gov (United States)

    2010-01-01

    ... and Compromise of Claims § 3.12 Reporting of consumer debts. (a) Notice. In demand letters to debtors... the delinquent consumer debt to credit reporting agencies after 60 days; (2) The specific information... credit bureaus. (d) Stay of disclosure. Agencies shall not disclose a delinquent debt to a credit...

  5. The effect of sports on level of community integration as reported by persons with spinal cord injury.

    Science.gov (United States)

    Hanson, C S; Nabavi, D; Yuen, H K

    2001-01-01

    The purpose of this study was to determine whether participation in sports by persons with spinal cord injuries (SCIs) affected level of community integration as defined by the World Health Organization and as measured by the Craig Handicap Assessment and Reporting Technique (CHART). Forty-eight participants were recruited from a camp for persons with physical disabilities as well as from SCI support groups. Participants were divided into groups of athletes (n = 30) and nonathletes (n = 18) on the basis of their self-reported level of sports participation. Athletes scored significantly higher on four of five subsections of the CHART (physical independence, mobility, occupation, social integration), indicating greater levels of community integration than nonathletes. These findings extend the literature outlining the physical and psychological benefits of sports. Occupational therapists have a unique opportunity to use the occupation of sports to integrate the roots of the profession with the cultural demands of society.

  6. A stiffly accurate integrator for elastodynamic problems

    KAUST Repository

    Michels, Dominik L.

    2017-07-21

    We present a new integration algorithm for the accurate and efficient solution of stiff elastodynamic problems governed by the second-order ordinary differential equations of structural mechanics. Current methods have the shortcoming that their performance is highly dependent on the numerical stiffness of the underlying system that often leads to unrealistic behavior or a significant loss of efficiency. To overcome these limitations, we present a new integration method which is based on a mathematical reformulation of the underlying differential equations, an exponential treatment of the full nonlinear forcing operator as opposed to more standard partially implicit or exponential approaches, and the utilization of the concept of stiff accuracy which ensures that the efficiency of the simulations is significantly less sensitive to increased stiffness. As a consequence, we are able to tremendously accelerate the simulation of stiff systems compared to established integrators and significantly increase the overall accuracy. The advantageous behavior of this approach is demonstrated on a broad spectrum of complex examples like deformable bodies, textiles, bristles, and human hair. Our easily parallelizable integrator enables more complex and realistic models to be explored in visual computing without compromising efficiency.

  7. Phelan-McDermid syndrome data network: Integrating patient reported outcomes with clinical notes and curated genetic reports.

    Science.gov (United States)

    Kothari, Cartik; Wack, Maxime; Hassen-Khodja, Claire; Finan, Sean; Savova, Guergana; O'Boyle, Megan; Bliss, Geraldine; Cornell, Andria; Horn, Elizabeth J; Davis, Rebecca; Jacobs, Jacquelyn; Kohane, Isaac; Avillach, Paul

    2017-09-01

    The heterogeneity of patient phenotype data are an impediment to the research into the origins and progression of neuropsychiatric disorders. This difficulty is compounded in the case of rare disorders such as Phelan-McDermid Syndrome (PMS) by the paucity of patient clinical data. PMS is a rare syndromic genetic cause of autism and intellectual deficiency. In this paper, we describe the Phelan-McDermid Syndrome Data Network (PMS_DN), a platform that facilitates research into phenotype-genotype correlation and progression of PMS by: a) integrating knowledge of patient phenotypes extracted from Patient Reported Outcomes (PRO) data and clinical notes-two heterogeneous, underutilized sources of knowledge about patient phenotypes-with curated genetic information from the same patient cohort and b) making this integrated knowledge, along with a suite of statistical tools, available free of charge to authorized investigators on a Web portal https://pmsdn.hms.harvard.edu. PMS_DN is a Patient Centric Outcomes Research Initiative (PCORI) where patients and their families are involved in all aspects of the management of patient data in driving research into PMS. To foster collaborative research, PMS_DN also makes patient aggregates from this knowledge available to authorized investigators using distributed research networks such as the PCORnet PopMedNet. PMS_DN is hosted on a scalable cloud based environment and complies with all patient data privacy regulations. As of October 31, 2016, PMS_DN integrates high-quality knowledge extracted from the clinical notes of 112 patients and curated genetic reports of 176 patients with preprocessed PRO data from 415 patients. © 2017 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.

  8. Management of periodontally compromised mandibular molar with Hemisectioning: A case report

    Directory of Open Access Journals (Sweden)

    Bandu Napte

    2014-01-01

    Full Text Available Introduction: Hemisection involves sectioning of a periodontally involved mandibular molar so as to remove the involved root and save the remaining tooth. This procedure helps in saving a tooth which otherwise would have been deemed for extraction. Hemisection refers to removal or separation of root with its accompanying crown portion of two-rooted teeth, most commonly mandibular molars. Method: In this case report, an advanced Endo-Perio lesion on a left mandibular first molar was successfully treated by root-canal treatment and hemisection. This procedure helps preserve the tooth structure, alveolar bone and promote cost savings over other treatment options. Conclusion: Hemisection is a treatment option for saving a mandibular molar which is in advanced stage of periodontal disease of one root. Removal of the affected root will help in retaining the remaining tooth structure.

  9. Life-threatening systemic toxicity and airway compromise from a common European adder bite to the tongue

    DEFF Research Database (Denmark)

    Hoegberg, L C G; Jessen, C L; Lambertsen, K

    2009-01-01

    , pharyngeal and facial oedema compromised the airway, leading to respiratory failure, concomitant with circulatory failure related to hypoxaemia and systemic toxic effects. Acute tracheotomy secured the airway, and two doses of antivenom successfully treated the systemic, toxic effects. The reaction...

  10. Thiamine absorption is not compromised in folate-deficient rats

    International Nuclear Information System (INIS)

    Walzem, R.L.; Clifford, A.J.

    1988-01-01

    Thiamine absorption and excretion were assessed in rats with severe folate deficiency (FD) by determining the fate of oral 3 H-labeled and intravenous 14 C-labeled thiamine over a 6-h test period. Thiamine status was evaluated in these same rats by measuring transketolase activity levels of blood before (TKA) and after (TPPE) addition of thiamine pyrophosphate to the incubation mixture of the assay procedure. Two additional experiments assessed active transport of thiamine and the effect of dietary succinylsulfathiazole (SST) on TKA and TPPE in rats with moderate FD. Intestinal absorption in general and thiamine absorption in particular and thiamine status were unaltered in rats with severe FD. Inanition associated with severe FD may impair thiamine status. Thiamine absorption by active transport was not compromised in FD, and dietary succinylsulfathiazole did not affect thiamine status

  11. 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells.

    Science.gov (United States)

    Bauer, Matthias R; Joerger, Andreas C; Fersht, Alan R

    2016-09-06

    The tumor suppressor p53 has the most frequently mutated gene in human cancers. Many of p53's oncogenic mutants are just destabilized and rapidly aggregate, and are targets for stabilization by drugs. We found certain 2-sulfonylpyrimidines, including one named PK11007, to be mild thiol alkylators with anticancer activity in several cell lines, especially those with mutationally compromised p53. PK11007 acted by two routes: p53 dependent and p53 independent. PK11007 stabilized p53 in vitro via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. Unstable p53 was reactivated by PK11007 in some cancer cell lines, leading to up-regulation of p53 target genes such as p21 and PUMA. More generally, there was cell death that was independent of p53 but dependent on glutathione depletion and associated with highly elevated levels of reactive oxygen species and induction of endoplasmic reticulum (ER) stress, as also found for the anticancer agent PRIMA-1(MET)(APR-246). PK11007 may be a lead for anticancer drugs that target cells with nonfunctional p53 or impaired reactive oxygen species (ROS) detoxification in a wide variety of mutant p53 cells.

  12. Resources from waste : integrated resource management phase 1 study report

    International Nuclear Information System (INIS)

    Corps, C.; Salter, S.; Lucey, P.; O'Riordan, J.

    2008-01-01

    Integrated resource management (IRM) of municipal waste streams and water systems requires a structured analysis of options that consider environmental aspects such as greenhouse gases, carbon taxes and credits. Each option's inputs and outputs are assessed to determine the net highest and best use and value. IRM focuses on resource recovery and extracting maximum value. It considers the overall net impact on the taxpayer and requires the integration of liquid and solid waste streams to maximize values for recovering energy in the form of biofuels, heat, minerals, water and reducing electricity demand. IRM is linked to water management through reuse of treated water for groundwater recharge and to offset potable water use for non-potable purposes such as irrigation, including potential commercial use, which contributes to maintaining or improving the health of watersheds. This report presented a conceptual design for the application of IRM in the province of British Columbia (BC) and analyzed its potential contribution to the provincial climate change agenda. The report discussed traditional waste management, the IRM approach, and resource recovery technology and opportunities. The business case for IRM in BC was also outlined. It was concluded that IRM has the potential to be a viable solution to water, solid and liquid waste management that should be less expensive, result in fewer environmental impacts, and provide greater flexibility than traditional approaches to waste management. 63 refs., 17 tabs., 21 figs., 10 appendices

  13. Independent peer review panel report on the integrated nonthermal treatment systems study and the comparison of integrated thermal and integrated nonthermal treatment systems for mixed low level waste

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    The US Department of Energy`s (DOE) Office of Environmental Management (EM) Office of Science and Technology (OST) has conducted studies of integrated thermal treatment systems and integrated nonthermal treatment systems (INTS) for treating contact handled, alpha and non-alpha mixed low level radioactive waste (MLLW). The MLLW in the DOE complex consists of a wide variety of organic and inorganic solids and liquids contaminated with radioactive substances. Treatment systems are needed to destroy organic material and stabilize residues prior to land disposal. In May 1996 the Deputy Assistant Secretary for OST appointed an Independent Peer Review Panel to: (1) review and comment on the INTS Study; (2) make recommendations on the most promising thermal and nonthermal treatment systems; (3) make recommendations on research and development necessary to prove the performance of nonthermal and thermal technologies; and (4) review and comment on the preliminary draft of the ITTS/INTS Comparison Report. This report presents the primary conclusions and recommendations based on the review of the INTS study and the comparison report. System selection, overviews, comparisons, cost estimations and sensitivity analyses, and recommended R and D engineering needs are then described and discussed.

  14. Independent peer review panel report on the integrated nonthermal treatment systems study and the comparison of integrated thermal and integrated nonthermal treatment systems for mixed low level waste

    International Nuclear Information System (INIS)

    1996-08-01

    The US Department of Energy's (DOE) Office of Environmental Management (EM) Office of Science and Technology (OST) has conducted studies of integrated thermal treatment systems and integrated nonthermal treatment systems (INTS) for treating contact handled, alpha and non-alpha mixed low level radioactive waste (MLLW). The MLLW in the DOE complex consists of a wide variety of organic and inorganic solids and liquids contaminated with radioactive substances. Treatment systems are needed to destroy organic material and stabilize residues prior to land disposal. In May 1996 the Deputy Assistant Secretary for OST appointed an Independent Peer Review Panel to: (1) review and comment on the INTS Study; (2) make recommendations on the most promising thermal and nonthermal treatment systems; (3) make recommendations on research and development necessary to prove the performance of nonthermal and thermal technologies; and (4) review and comment on the preliminary draft of the ITTS/INTS Comparison Report. This report presents the primary conclusions and recommendations based on the review of the INTS study and the comparison report. System selection, overviews, comparisons, cost estimations and sensitivity analyses, and recommended R and D engineering needs are then described and discussed

  15. Integrated Reporting: A Review of Developments and Their Implications for the Accounting Curriculum

    Science.gov (United States)

    Owen, Gareth

    2013-01-01

    Integrated reporting (IR) is a major development in a number of sustainability-related accounting initiatives and, if widely adopted, will require significant developments in professional and university accounting curricula. These will include: a strategic rather than operational or transactional focus; longer- rather than short-term outlook;…

  16. Integrated dry NO{sub x}/SO{sub 2} emissions control system: integrated system test report

    Energy Technology Data Exchange (ETDEWEB)

    Smith, R.A.; Muzio, L.J. [Fossil Energy Research Corp., Laguna Hills, CA (United States); Hunt, T. [Public Service Co. of Colorado, Denver, CO (United States)

    1997-04-01

    The DOE sponsored Integrated Dry NO{sub x}/SO{sub 2} Emissions Control System Program, is a Clean Coal Technology III demonstration, being conducted by Public Service Company of Colorado. The test site is Arapahoe Generating Station Unit 4, a 100 MWe, down-fired utility boiler burning a low-sulfur Western coal. The project goal is to demonstrate up to 70 percent reductions in NO{sub x} and SO{sub 2} emissions through the integration of: (1) down-fired low NO{sub x} burners with overfire air; (2) Selective Non-Catalytic Reduction (SNCR) for additional NO{sub x} removal; and (3) Dry Sorbent Injection (DSI) and duct humidification for SO{sub 2} removal. This report documents the final phase of the test program, in which the overall performance of the integrated system was evaluated. Previous testing has shown that the goal of 70 percent NO{sub x} removal was easily achieved with the combination of low-NO{sub x} burners, overfire air, and urea-based SNCR. Similarly, the ability of the sodium-based DSI system to achieve 70 percent SO{sub 2} removal was also demonstrated previously. The integrated tests demonstrated the synergistic benefit of operating the SNCR and sodium-based DSI systems concurrently. With the automatic control system set to limit the NH{sub 3} emissions to less than 8 ppm, the NO{sub 2} emissions from the sodium-based DSI system were reduced by nominally 50 percent compared to operation with the DSI system alone. Comparably, the combined operation reduced NH{sub 3} emissions, as reflected by a higher urea injection rate for a fixed NH{sub 3} emission limit. With combined DSI and SNCR operation, an ammonia odor problem was encountered around the Unit 4 ash silo (this did not occur with the SNCR system operated alone at comparable NH{sub 3} slip levels). This odor problem is attributed to the sodium changing the rate at which NH{sub 3} is released from the ash when it is wetted for truck transport to the disposal site.

  17. Using Emergence Theory-Based Curriculum to Teach Compromise Skills to Students with Autistic Spectrum Disorders

    Science.gov (United States)

    Fein, Lance; Jones, Don

    2015-01-01

    This study addresses the compromise skills that are taught to students diagnosed with autistic spectrum disorders (ASD) and related social and communication deficits. A private school in the southeastern United States implemented an emergence theory-based curriculum to address these skills, yet no formal analysis was conducted to determine its…

  18. Evaluation of stream ecological integrity using litter decomposition and benthic invertebrates

    Energy Technology Data Exchange (ETDEWEB)

    Castela, Jose [Departamento de Zoologia and IMAR-CIC, Universidade de Coimbra, Largo Marques de Pombal, 3004-517 Coimbra (Portugal)], E-mail: jcccastela@gmail.com; Ferreira, Veronica [Departamento de Zoologia and IMAR-CIC, Universidade de Coimbra, Largo Marques de Pombal, 3004-517 Coimbra (Portugal)], E-mail: veronica@ci.uc.pt; Graca, Manuel A.S. [Departamento de Zoologia and IMAR-CIC, Universidade de Coimbra, Largo Marques de Pombal, 3004-517 Coimbra (Portugal)], E-mail: mgraca@ci.uc.pt

    2008-05-15

    Biomonitoring programs to access the ecological integrity of freshwaters tend to rely exclusively on structural parameters. Here we evaluated stream ecological integrity using (a) benthic macroinvertebrate derived metrics and a biotic index as measures of structural integrity and (b) oak litter decomposition and associated fungal sporulation rates as measures of functional integrity. The study was done at four sites (S1, S2, S3 and S4) along a downstream increasing phosphorus and habitat degradation gradient in a small stream. The biotic index, invertebrate metrics, invertebrate and fungal communities' structure and sporulation rates discriminated upstream and downstream sites. Decomposition rates classified sites S4 and S2 as having a compromised ecosystem functioning. Although both functional and structural approaches gave the same results for the most impacted site (S4), they were complementary for moderately impacted sites (S2 and S3), and we therefore support the need for incorporating functional measures in evaluations of stream ecological integrity. - This study supports the need for incorporating functional measures in evaluations of stream ecological integrity.

  19. Evaluation of stream ecological integrity using litter decomposition and benthic invertebrates

    International Nuclear Information System (INIS)

    Castela, Jose; Ferreira, Veronica; Graca, Manuel A.S.

    2008-01-01

    Biomonitoring programs to access the ecological integrity of freshwaters tend to rely exclusively on structural parameters. Here we evaluated stream ecological integrity using (a) benthic macroinvertebrate derived metrics and a biotic index as measures of structural integrity and (b) oak litter decomposition and associated fungal sporulation rates as measures of functional integrity. The study was done at four sites (S1, S2, S3 and S4) along a downstream increasing phosphorus and habitat degradation gradient in a small stream. The biotic index, invertebrate metrics, invertebrate and fungal communities' structure and sporulation rates discriminated upstream and downstream sites. Decomposition rates classified sites S4 and S2 as having a compromised ecosystem functioning. Although both functional and structural approaches gave the same results for the most impacted site (S4), they were complementary for moderately impacted sites (S2 and S3), and we therefore support the need for incorporating functional measures in evaluations of stream ecological integrity. - This study supports the need for incorporating functional measures in evaluations of stream ecological integrity

  20. Gpr124 is essential for blood-brain barrier integrity in central nervous system disease.

    Science.gov (United States)

    Chang, Junlei; Mancuso, Michael R; Maier, Carolina; Liang, Xibin; Yuki, Kanako; Yang, Lu; Kwong, Jeffrey W; Wang, Jing; Rao, Varsha; Vallon, Mario; Kosinski, Cynthia; Zhang, J J Haijing; Mah, Amanda T; Xu, Lijun; Li, Le; Gholamin, Sharareh; Reyes, Teresa F; Li, Rui; Kuhnert, Frank; Han, Xiaoyuan; Yuan, Jenny; Chiou, Shin-Heng; Brettman, Ari D; Daly, Lauren; Corney, David C; Cheshier, Samuel H; Shortliffe, Linda D; Wu, Xiwei; Snyder, Michael; Chan, Pak; Giffard, Rona G; Chang, Howard Y; Andreasson, Katrin; Kuo, Calvin J

    2017-04-01

    Although blood-brain barrier (BBB) compromise is central to the etiology of diverse central nervous system (CNS) disorders, endothelial receptor proteins that control BBB function are poorly defined. The endothelial G-protein-coupled receptor (GPCR) Gpr124 has been reported to be required for normal forebrain angiogenesis and BBB function in mouse embryos, but the role of this receptor in adult animals is unknown. Here Gpr124 conditional knockout (CKO) in the endothelia of adult mice did not affect homeostatic BBB integrity, but resulted in BBB disruption and microvascular hemorrhage in mouse models of both ischemic stroke and glioblastoma, accompanied by reduced cerebrovascular canonical Wnt-β-catenin signaling. Constitutive activation of Wnt-β-catenin signaling fully corrected the BBB disruption and hemorrhage defects of Gpr124-CKO mice, with rescue of the endothelial gene tight junction, pericyte coverage and extracellular-matrix deficits. We thus identify Gpr124 as an endothelial GPCR specifically required for endothelial Wnt signaling and BBB integrity under pathological conditions in adult mice. This finding implicates Gpr124 as a potential therapeutic target for human CNS disorders characterized by BBB disruption.

  1. Optimizing Maxillary Aesthetics of a Severe Compromised Tooth through Orthodontic Movement and Dental Implants

    Directory of Open Access Journals (Sweden)

    Rafael Scaf de Molon

    2014-01-01

    Full Text Available Treatment of severe compromised tooth in the maxillary anterior area still poses great challenge to the clinicians. Several treatment modalities have been proposed to restore the function and aesthetics in teeth with advanced periodontal disease. The present study aims to report a case of traumatic injury of a left-maxillary central incisor with ridge preservation, orthodontic movement, and implant therapy. A 45-year-old woman underwent the proposed treatment for her left central incisor: basic periodontal therapy, xenogenous bone graft, and guided bone regeneration (GBR. Six months after the graft procedure, orthodontic movement by means of alignment and leveling was made and a coronal displacement of the gingival margin and vertical bone apposition could be observed after 13 months of active movement. Afterwards, a dental implant was placed followed by a connective tissue graft and immediate provisionalization of the crown. In conclusion, orthodontic movement was effective to improve the gingival tissue and alveolar bone prior to implant placement favoring the aesthetic results. Six years postoperatively, the results revealed height and width alveolar bone gain indicating that the treatment proposed was able to restore all the functional and aesthetic parameters.

  2. The integrated management for renal replacement therapy in Portugal.

    Science.gov (United States)

    Coelho, Anabela P; Sá, Helena O; Diniz, José A; Dussault, Gilles

    2014-01-01

    Portugal was the first European country to introduce an integrated management of end-stage renal disease (IM ESRD). This new program integrates various dialysis services and products, which are reimbursed at a fixed rate/patient/week called "comprehensive price payment." This initiative restructured the delivery of dialysis services, the monitoring of outcomes, and the funding of renal replacement therapy. This article described the implementation of a new model of comprehensive provision of hemodialysis (HD) services and aimed to assess its impact on dialysis care. Quality assessments and reports of patient satisfaction, produced by the Ministry of Health since 2008, as well as national registries and reports, provided the data for this review. Indicators of HD services in all continental facilities show positive results that have successively improved along the period of 2009-2011, in spite of an average annual growth of 3% of the population under HD treatment. Mortality rates for HD patients were 12.7%, 12%, and 11%, respectively in 2009, 2010, and 2011; annual hospitalization rates were 4.9%, 3.8%, and 4.4% for the same years; key performance indicators showed averages above the reference values such as hemoglobin, serum phosphorus, eKt/V, water quality, number of days of hospitalization per patient per year, and number of weekly dialysis sessions. The financing analysis of IM ESRD demonstrates a sustained control of global costs, without compromising quality. The IM ERSD program is an innovative and quality-driven approach that benefits both dialysis patients and providers, contributing toward the rationalization of service provision and the efficient use of resources. © 2013 International Society for Hemodialysis.

  3. Managing Campus Energy: Compromising between Rapid Needs and Environmental Requirement

    Science.gov (United States)

    Ambariyanto, Ambariyanto; Utama, Yos J.; Purwanto

    2018-02-01

    The utilization of energy, especially electricity at Diponegoro University campus continues to increase in line with the development of the university. This increase has a direct impact on the increased costs to be paid by the university. Some of the causes of increased utilization of electrical energy is the construction of new buildings to meet the needs, increased learning activities and education, research activities in the laboratory, and various other activities. On the other hand, the increase of energy utilization is considered not good from the environment point of view, especially the utilization of electrical energy coming from non sustainable resources. Efforts to compromise on both are to develop policies in developing environmentally friendly buildings, efficiency in utilization of electrical energy, and development of sustainable energy sources.

  4. CO2-driven compromises to marine life along the Chilean coast

    Science.gov (United States)

    Mayol, E.; Ruiz-Halpern, S.; Duarte, C. M.; Castilla, J. C.; Pelegrí, J. L.

    2010-12-01

    CO2-driven compromises to marine life were examined along the Chilean sector of the Humboldt Current System, a particularly vulnerable hypoxic and upwelling area, applying the Respiration index (RI = log10 pO2) and the pH-dependent aragonite saturation (Ω) to delineate the water masses where aerobic and calcifying organisms are stressed. There was a remarkable negative relationship between oxygen concentration and pH or pCO2 in the studied area, with the subsurface hypoxic Equatorial Subsurface Waters extending from 100 m to about 300 m depth and supporting elevated pCO2 values. The RI reached a minimum at about 200 m depth and decreased towards the Equator. Increased pCO2 in the hypoxic water layer reduced the RI values by as much as 0.59 RI units, with the upper water layer that presents conditions suitable for aerobic life (RI>0.7) declining by half between 42° S and 28° S. The intermediate waters hardly reached those stations closer to the equator so that the increased pCO2 lowered pH and the saturation of aragonite. A significant fraction of the water column along the Chilean sector of the Humboldt Current System suffers from CO2-driven compromises to biota, including waters corrosive to calcifying organisms, stress to aerobic organisms or both. The habitat free of CO2-driven stresses was restricted to the upper mixed layer and to small water parcels at about 1000 m depth. pCO2 acts as a hinge connecting respiratory and calcification challenges expected to increase in the future, resulting in a spread of the challenges to aerobic organisms.

  5. Natural Tooth Pontic: An Instant Esthetic Option for Periodontally Compromised Teeth—A Case Series

    Directory of Open Access Journals (Sweden)

    Rishi Raj

    2016-01-01

    Full Text Available Sudden tooth loss in the esthetic zone of the maxillary or mandibular anterior region can be due to trauma, periodontal disease, or endodontic failure. The treatment options for replacing the missing tooth can vary between removable prosthesis, tooth-supported prosthesis, and implant-supported prosthesis. Irrespective of the final treatment, the first line of management would be to provisionally restore the patient’s esthetic appearance at the earliest, while functionally stabilizing the compromised arch. Using the patient’s own natural tooth as a pontic offers the benefits of being the right size, shape, and color and provides exact repositioning in its original intraoral three-dimensional position. Additionally, using the patient’s platelet concentrate (platelet rich fibrin facilitates early wound healing and preservation of alveolar ridge shape following tooth extraction. The abutment teeth can also be preserved with minimal or no preparation, thus keeping the technique reversible, and can be completed at the chair side thereby avoiding laboratory costs. This helps the patient better tolerate the effect of tooth loss psychologically. The article describes a successful, immediate, and viable technique for rehabilitation of three different patients requiring replacement of a single periodontally compromised tooth in an esthetic region.

  6. Can Neglected Tropical Diseases Compromise Human Wellbeing in Sex-, Age-, and Trait-Specific Ways?

    Directory of Open Access Journals (Sweden)

    David C Geary

    2016-04-01

    Full Text Available Traits that facilitate competition for reproductive resources or that influence mate choice have evolved to signal resilience to infectious disease and other stressors. As a result, the dynamics of competition and choice can, in theory, be used to generate predictions about sex-, age-, and trait-specific vulnerabilities for any sexually reproducing species, including humans. These dynamics and associated vulnerabilities are reviewed for nonhuman species, focusing on traits that are compromised by exposure to parasites. Using the same approach, sex-, age-, and trait-specific vulnerabilities to parasitic disease are illustrated for children's and adolescent's physical growth and fitness. Suggestions are then provided for widening the assessment of human vulnerabilities to include age-appropriate measures of behavioral (e.g., children's play and cognitive (e.g., language fluency traits. These are traits that are likely to be compromised by infection in age- and sex-specific ways. Inclusion of these types of measures in studies of neglected tropic diseases has the potential to provide a more nuanced understanding of how these diseases undermine human wellbeing and may provide a useful means to study the efficacy of associated treatments.

  7. Prosthodontic decision-making relating to dentitions with compromised molars: the perspective of Swedish General Dental Practitioners.

    Science.gov (United States)

    Korduner, E-K; Collin Bagewitz, I; Vult von Steyern, P; Wolf, E

    2016-12-01

    The aim of this investigation was to study the clinical prosthodontic decision-making process relating to dentitions with compromised molars among Swedish general dental practitioners (GDPs). Eleven Swedish GDPs were purposively selected, and all agreed to participate. Then, in-depth, semi-structured interviews were conducted and covered treatment considerations concerning two authentic patient cases, initially with complete dental arches, and later, a final treatment based on a shortened dental arch (SDA) was discussed. The cases involved patients with compromised teeth situated mainly in the molar regions. One patient suffered from extensive caries and the other from severe periodontal disease. Qualitative content analysis was used to analyse the data. In the systematic analysis, two main categories were identified: holistic and functional approach. Among the interviewed GDPs, focus was put on patients' needs, background history and motivation for treatment as well as the preservation of molar support. Within the limitations of this study, the following can be concluded: keeping a dental arch with molars seems to be important to Swedish general dental practitioners. The SDA concept does not seem to have a substantial impact on the prosthodontic decision-making relating to dentitions with compromised molars. The dentist's experiences, as well as colleagues' or consulting specialist advice together with aetiological factors and the patient's individual situation, influence the decision-making more than the SDA concept. The conflicting results in the prosthetic decision-making process concerning the relevance of age and the need for molar support need further investigation, for example based on decisions made in the dentist's own clinical practice. © 2016 John Wiley & Sons Ltd.

  8. Idaho National Laboratory Integrated Safety Management System FY 2012 Effectiveness Review and Declaration Report

    Energy Technology Data Exchange (ETDEWEB)

    Farren Hunt

    2012-12-01

    Idaho National Laboratory (INL) performed an Annual Effectiveness Review of the Integrated Safety Management System (ISMS), per 48 Code of Federal Regulations (CFR) 970.5223 1, “Integration of Environment, Safety and Health into Work Planning and Execution.” The annual review assessed Integrated Safety Management (ISM) effectiveness, provided feedback to maintain system integrity, and identified target areas for focused improvements and assessments for fiscal year (FY) 2013. Results of the FY 2012 annual effectiveness review demonstrated that the INL’s ISMS program was significantly strengthened. Actions implemented by the INL demonstrate that the overall Integrated Safety Management System is sound and ensures safe and successful performance of work while protecting workers, the public, and environment. This report also provides several opportunities for improvement that will help further strengthen the ISM Program and the pursuit of safety excellence. Demonstrated leadership and commitment, continued surveillance, and dedicated resources have been instrumental in maturing a sound ISMS program. Based upon interviews with personnel, reviews of assurance activities, and analysis of ISMS process implementation, this effectiveness review concludes that ISM is institutionalized and is “Effective”.

  9. Integrated environmental control and monitoring in the intelligent workplace. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    This project involved the design and engineering of the control and monitoring of environmental quality - visual, thermal, air - in the Intelligent Workplace. The research objectives were to study the performance of the individual systems, to study the integration issues related to each system, to develop a control plan, and to implement and test the integrated systems in a real setting. In this project, a control strategy with related algorithms for distributed sensors, actuators, and controllers for negotiating central and individual control of HVAC, lighting, and enclosure was developed in order to maximize user comfort, and energy and environmental effectiveness. The goal of the control system design in the Intelligent Workplace is the integration of building systems for optimization of occupant satisfaction, organizational flexibility, energy efficiency and environmental effectiveness. The task of designing this control system involves not only the research, development and demonstration of state-of-the-art mechanical and electrical systems, but also their integration. The ABSIC research team developed functional requirements for the environmental systems considering the needs of both facility manager and the user. There are three levels of control for the environmental systems: scheduled control, sensor control, and user control. The challenges are to achieve the highest possible levels of energy effectiveness simultaneously with the highest levels of user satisfaction. The report describes the components of each system, their implementation in the Intelligent Workplace and related control and monitoring issues.

  10. The Role Of Grenelle II In Corporate Social Responsibility Integrated Reporting

    Directory of Open Access Journals (Sweden)

    Radoslaw Wolniak

    2013-12-01

    Full Text Available There is in the paper, the analysis of the Grenelle II act from Corporate Social Responsibility reporting point of view. France has long been an important global champion of corporate sustainability reporting. While this trend has advanced the integration of CSR into business practices, the increasing number of regulations has also made it more complicated and costly for international companies to create reports that fulfill the differing requirements of each foreign law. The Grenelle 2 law adopted in July 2010, implements the Grenelle 1 goals. It sets specific objectives, strategic, incentives and regulations. This Act aims at forcing companies to progress in reporting their environmental and social information: there is no sanction (such as fines, requirements are on a “comply or explain” basis and the implementation is progressive. The main advantage of such an Grenelle II Act is a beginning and will have to be rewritten and improved, taking into account the international movement – is to shift minds regarding CSR. CSR and extra-financial information has nothing to do with communication anymore: it is clearly a strategic and management process, facilitated by the reporting process.

  11. Modelling of Operative Report Documents for Data Integration into an openEHR-Based Enterprise Data Warehouse.

    Science.gov (United States)

    Haarbrandt, Birger; Wilschko, Andreas; Marschollek, Michael

    2016-01-01

    In order to integrate operative report documents from two operating room management systems into a data warehouse, we investigated the application of the two-level modelling approach of openEHR to create a shared data model. Based on the systems' analyses, a template consisting of 13 archetypes has been developed. Of these 13 archetypes, 3 have been obtained from the international archetype repository of the openEHR foundation. The remaining 10 archetypes have been newly created. The template was evaluated by an application system expert and through conducting a first test mapping of real-world data from one of the systems. The evaluation showed that by using the two-level modelling approach of openEHR, we succeeded to represent an integrated and shared information model for operative report documents. More research is needed to learn about the limitations of this approach in other data integration scenarios.

  12. Chronic Lymphocytic Leukemia as an Unusual Cause of Rapid Airway Compromise

    Directory of Open Access Journals (Sweden)

    Adrian R. Bersabe

    2017-01-01

    Full Text Available Chronic Lymphocytic Leukemia (CLL is the most prevalent form of non-Hodgkin’s lymphoma (NHL in Western countries predominantly affecting adults over the age of 65. CLL is commonly indolent in nature but can present locally and aggressively at extranodal sites. Although CLL may commonly present with cervical lymphadenopathy, manifestation in nonlymphoid regions of the head and neck is not well described. CLL causing upper airway obstruction is even more uncommon. We describe a case of a patient with known history of CLL and stable lymphocytosis that developed an enlarging lymphoid base of tongue (BOT mass resulting in rapid airway compromise.

  13. The European directive on renewable electricity: conflicts and compromises

    International Nuclear Information System (INIS)

    Rowlands, I.H.

    2005-01-01

    As part of its efforts to increase the use of renewable energy in Europe, a Directive regarding renewable electricity was agreed by the European Union in 2001. The purpose of this article is to examine this Directive, examining how the discussions surrounding its content unfolded. The investigation focuses upon three contentious issues that were debated during the Directive's development: the definition of 'renewable', the national targets for renewable electricity (their levels, as well as whether they should be 'binding' or 'indicative') and the questions associated with harmonisation (whether one Union-wide 'support scheme' for renewable electricity should be in place, and, if so, what it should be). During the 5 years that the Directive was negotiated, many intra-Union conflicts were eventually resolved, at least temporarily, by compromises. Nevertheless, some difficult decisions regarding the promotion of renewable electricity in the European Union still have to be taken

  14. Enhanced susceptibility to predation in corals of compromised condition.

    Science.gov (United States)

    Bright, Allan J; Cameron, Caitlin M; Miller, Margaret W

    2015-01-01

    The marine gastropod, Coralliophila abbreviata, is an obligate corallivore that causes substantial mortality in Caribbean Acropora spp. Considering the imperiled status of Acropora cervicornis and A. palmata, a better understanding of ecological interactions resulting in tissue loss may enable more effective conservation strategies. We examined differences in susceptibility of A. cervicornis to C. abbreviata predation based on coral tissue condition. Coral tissue condition was a strong determinant of snail prey choice, with snails preferring A. cervicornis fragments that were diseased or mechanically damaged over healthy fragments. In addition, snails always chose fragments undergoing active predation by another snail, while showing no preference for a non-feeding snail when compared with an undisturbed prey fragment. These results indicate that the condition of A. cervicornis prey influenced foraging behavior of C. abbreviata, creating a potential feedback that may exacerbate damage from predation in coral populations compromised by other types of disturbance.

  15. Promoting equity through integrated early child development and nutrition interventions.

    Science.gov (United States)

    Black, Maureen M; Dewey, Kathryn G

    2014-01-01

    Sustainable development, a foundation of the post-2015 global agenda, depends on healthy and productive citizens. The origins of adult health begin early in life, stemming from genetic-environmental interactions that include adequate nutrition and opportunities for responsive learning. Inequities associated with inadequate nutrition and early learning opportunities can undermine children's health and development, thereby compromising their productivity and societal contributions. Transactional theory serves as a useful framework for examining the associations that link early child development and nutrition because it emphasizes the interplay that occurs between children and the environment, mediated through caregiver interactions. Although single interventions targeting early child development or nutrition can be effective, there is limited evidence on the development, implementation, evaluation, and scaling up of integrated interventions. This manuscript introduces a special edition of papers on six topics central to integrated child development/nutrition interventions: (1) review of integrated interventions; (2) methods and topics in designing integrated interventions; (3) economic considerations related to integrated interventions; (4) capacity-building considerations; (5) examples of integrated interventions; and (6) policy implications of integrated interventions. Ensuring the health and development of infants and young children through integrated child development/nutrition interventions promotes equity, a critical component of sustainable development. © 2014 New York Academy of Sciences.

  16. Integrated System Health Management (ISHM) Technology Demonstration Project Final Report

    Science.gov (United States)

    Mackey, Ryan; Iverson, David; Pisanich, Greg; Toberman, Mike; Hicks, Ken

    2006-01-01

    Integrated System Health Management (ISHM) is an essential capability that will be required to enable upcoming explorations mission systems such as the Crew Exploration Vehicle (CEV) and Crew Launch Vehicle (CLV), as well as NASA aeronautics missions. However, the lack of flight experience and available test platforms have held back the infusion by NASA Ames Research Center (ARC) and the Jet Propulsion Laboratory (JPL) of ISHM technologies into future space and aeronautical missions. To address this problem, a pioneer project was conceived to use a high-performance aircraft as a low-cost proxy to develop, mature, and verify the effectiveness of candidate ISHM technologies. Given the similarities between spacecraft and aircraft, an F/A-18 currently stationed at Dryden Flight Research Center (DFRC) was chosen as a suitable host platform for the test bed. This report describes how the test bed was conceived, how the technologies were integrated on to the aircraft, and how these technologies were matured during the project. It also describes the lessons learned during the project and a forward path for continued work.

  17. Integrity and moral residue: nurses as participants in a moral community.

    Science.gov (United States)

    Hardingham, Lorraine B

    2004-07-01

    This paper will examine the concepts of integrity and moral residue as they relate to nursing practice in the current health care environment. I will begin with my definition and conception of ethical practice, and, based on that, will go on to argue for the importance of recognizing that nurses often find themselves in the position of compromising their moral integrity in order to maintain their self-survival in the hospital or health care environment. I will argue that moral integrity is necessary to a moral life, and is relational in nature. When integrity is threatened, the result is moral distress, moral residue, and in some cases, abandonment of the profession. The solution will require more than teaching bioethics to nursing students and nurses. It will require changes in the health care environment, organizational culture and the education of nurses, with an emphasis on building a moral community as an environment in which to practise ethically.

  18. Steam generator tube integrity program. Semiannual report, August 1995--March 1996

    International Nuclear Information System (INIS)

    Diercks, D.R.; Bakhtiari, S.; Chopra, O.K.

    1997-04-01

    This report summarizes work performed by Argonne National Laboratory on the Steam Generator Tube Integrity Program from the inception of that program in August 1995 through March 1996. The program is divided into five tasks, namely (1) Assessment of Inspection Reliability, (2) Research on ISI (in-service-inspection) Technology, (3) Research on Degradation Modes and Integrity, (4) Development of Methodology and Technical Requirements for Current and Emerging Regulatory Issues, and (5) Program Management. Under Task 1, progress is reported on the preparation of and evaluation of nondestructive evaluation (NDE) techniques for inspecting a mock-up steam generator for round-robin testing, the development of better ways to correlate burst pressure and leak rate with eddy current (EC) signals, the inspection of sleeved tubes, workshop and training activities, and the evaluation of emerging NDE technology. Under Task 2, results are reported on closed-form solutions and finite element electromagnetic modeling of EC probe response for various probe designs and flaw characteristics. Under Task 3, facilities are being designed and built for the production of cracked tubes under aggressive and near-prototypical conditions and for the testing of flawed and unflawed tubes under normal operating, accident, and severe accident conditions. In addition, crack behavior and stability are being modeled to provide guidance on test facility design, to develop an improved understanding of the expected rupture behavior of tubes with circumferential cracks, and to predict the behavior of flawed and unflawed tubes under severe accident conditions. Task 4 is concerned with the cracking and failure of tubes that have been repaired by sleeving, and with a review of literature on this subject

  19. Czech Republic : Report on Vision and Strategy for an Integrated Revenue Administration

    OpenAIRE

    World Bank

    2009-01-01

    This report is a result of the mission of the World Bank to the Czech Republic during November 17 to 27, 2008 for providing advisory service to the Government of the Czech Republic for the design and development of a modern, integrated revenue authority. Earlier, between February and April 2008, a World Bank mission had reviewed the draft merger plan prepared by the Ministry of Finance of ...

  20. Orientation of handle for successful prosthetic treatment in patients with an anatomic compromise after a maxillectomy.

    Science.gov (United States)

    Sumita, Yuka I; Hattori, Mariko; Elbashti, Mahmoud E; Taniguchi, Hisashi

    2017-05-01

    This clinical technique provides a key procedure for successful prosthetic treatment in patients with an anatomical compromise after a maxillectomy. When making a preliminary impression, the clinician must keep the handle of the stock tray parallel to the patient's interpupillary line extraorally to maintain the correct position of the tray and to make a record of the inclination of the occlusal plane. This simple consideration during this first step of making a preliminary impression can be an important guide for both dentists and dental technicians. Information about the correct positioning of the tray and the inclination of the occlusal plane obtained by using a stock tray handle will greatly reduce the stress experienced by dentists, dental technicians, and patients during the fabrication of the prosthesis and will ultimately lead to successful prosthetic treatment in patients with anatomic compromise resulting from a maxillectomy. Copyright © 2016 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  1. Methodology for dimensional variation analysis of ITER integrated systems

    International Nuclear Information System (INIS)

    Fuentes, F. Javier; Trouvé, Vincent; Cordier, Jean-Jacques; Reich, Jens

    2016-01-01

    Highlights: • Tokamak dimensional management methodology, based on 3D variation analysis, is presented. • Dimensional Variation Model implementation workflow is described. • Methodology phases are described in detail. The application of this methodology to the tolerance analysis of ITER Vacuum Vessel is presented. • Dimensional studies are a valuable tool for the assessment of Tokamak PCR (Project Change Requests), DR (Deviation Requests) and NCR (Non-Conformance Reports). - Abstract: The ITER machine consists of a large number of complex systems highly integrated, with critical functional requirements and reduced design clearances to minimize the impact in cost and performances. Tolerances and assembly accuracies in critical areas could have a serious impact in the final performances, compromising the machine assembly and plasma operation. The management of tolerances allocated to part manufacture and assembly processes, as well as the control of potential deviations and early mitigation of non-compliances with the technical requirements, is a critical activity on the project life cycle. A 3D tolerance simulation analysis of ITER Tokamak machine has been developed based on 3DCS dedicated software. This integrated dimensional variation model is representative of Tokamak manufacturing functional tolerances and assembly processes, predicting accurate values for the amount of variation on critical areas. This paper describes the detailed methodology to implement and update the Tokamak Dimensional Variation Model. The model is managed at system level. The methodology phases are illustrated by its application to the Vacuum Vessel (VV), considering the status of maturity of VV dimensional variation model. The following topics are described in this paper: • Model description and constraints. • Model implementation workflow. • Management of input and output data. • Statistical analysis and risk assessment. The management of the integration studies based on

  2. Methodology for dimensional variation analysis of ITER integrated systems

    Energy Technology Data Exchange (ETDEWEB)

    Fuentes, F. Javier, E-mail: FranciscoJavier.Fuentes@iter.org [ITER Organization, Route de Vinon-sur-Verdon—CS 90046, 13067 St Paul-lez-Durance (France); Trouvé, Vincent [Assystem Engineering & Operation Services, rue J-M Jacquard CS 60117, 84120 Pertuis (France); Cordier, Jean-Jacques; Reich, Jens [ITER Organization, Route de Vinon-sur-Verdon—CS 90046, 13067 St Paul-lez-Durance (France)

    2016-11-01

    Highlights: • Tokamak dimensional management methodology, based on 3D variation analysis, is presented. • Dimensional Variation Model implementation workflow is described. • Methodology phases are described in detail. The application of this methodology to the tolerance analysis of ITER Vacuum Vessel is presented. • Dimensional studies are a valuable tool for the assessment of Tokamak PCR (Project Change Requests), DR (Deviation Requests) and NCR (Non-Conformance Reports). - Abstract: The ITER machine consists of a large number of complex systems highly integrated, with critical functional requirements and reduced design clearances to minimize the impact in cost and performances. Tolerances and assembly accuracies in critical areas could have a serious impact in the final performances, compromising the machine assembly and plasma operation. The management of tolerances allocated to part manufacture and assembly processes, as well as the control of potential deviations and early mitigation of non-compliances with the technical requirements, is a critical activity on the project life cycle. A 3D tolerance simulation analysis of ITER Tokamak machine has been developed based on 3DCS dedicated software. This integrated dimensional variation model is representative of Tokamak manufacturing functional tolerances and assembly processes, predicting accurate values for the amount of variation on critical areas. This paper describes the detailed methodology to implement and update the Tokamak Dimensional Variation Model. The model is managed at system level. The methodology phases are illustrated by its application to the Vacuum Vessel (VV), considering the status of maturity of VV dimensional variation model. The following topics are described in this paper: • Model description and constraints. • Model implementation workflow. • Management of input and output data. • Statistical analysis and risk assessment. The management of the integration studies based on

  3. 2014 Strategic Petroleum Reserve Bryan Mound Well Integrity Grading Report.

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, Barry L; Lord, David; Lord, Anna C. Snider; Bettin, Giorgia; Sobolik, Steven R.; Rudeen, David Keith; Eldredge, Lisa L. (FFPO); Wynn, Karen (FFPO); Checkai, Dean (FFPO); Osborne, Gerad (FFPO); Moore, Darryl (FFPO)

    2015-04-01

    This report summarizes the work performed in the prioritization of cavern access wells for remediation and monitoring at the Bryan Mound Strategic Petroleum Reserve site. The grading included consideration of all 47 wells at the Bryan Mound site, with each well receiving a separate grade for remediation and monitoring. Numerous factors affecting well integrity were incorporated into the grading including casing survey results, cavern pressure history, results from geomechanical simulations, and site geologic factors. The factors and grading framework used here are the same as those used in developing similar well remediation and monitoring priorities at the Big Hill Strategic Petroleum Reserve Site.

  4. 2013 strategic petroleum reserve big hill well integrity grading report.

    Energy Technology Data Exchange (ETDEWEB)

    Lord, David L.; Roberts, Barry L.; Lord, Anna C. Snider; Bettin, Giorgia; Sobolik, Steven Ronald; Park, Byoung Yoon; Rudeen, David Keith; Eldredge, Lisa; Wynn, Karen; Checkai, Dean; Perry, James Thomas

    2014-02-01

    This report summarizes the work performed in developing a framework for the prioritization of cavern access wells for remediation and monitoring at the Big Hill Strategic Petroleum Reserve site. This framework was then applied to all 28 wells at the Big Hill site with each well receiving a grade for remediation and monitoring. Numerous factors affecting well integrity were incorporated into the grading framework including casing survey results, cavern pressure history, results from geomechanical simulations, and site geologic factors. The framework was developed in a way as to be applicable to all four of the Strategic Petroleum Reserve sites.

  5. Progress Report 16 for the period April-September 1980, and the proceedings of the 16th Project Integration Meeting

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, R.R.

    1980-01-01

    Progress made by the Low-Cost Solar Array Project during the period April to September 1980, is reported in detail. Progress on project analysis and integration; technology development in silicon material, large-area silicon sheet and encapsulation; production process and equipment development; engineering, and operations is described. A report on, and copies of visual presentations made at, the Project Integration Meeting held September 24 and 25, 1980 are included.

  6. Navigating safety necessary compromises and trade-offs : theory and practice

    CERN Document Server

    Amalberti, René

    2013-01-01

    Managing safety in a professional environment requires constant negotiation with other competitive dimensions of risk management (finances, market and political drivers, manpower and social crisis). This is obvious, although generally not said in safety manuals. The book provides a unique vision of how to best find these compromises, starting with lessons learnt from natural risk management by individuals, then applying them to the craftsman industry, complex industrial systems (civil aviation, nuclear energy) and public services (like transportation and medicine). It offers a unique, illustrated, easy to read and scientifically based set of original concepts and pragmatic methods to revisit safety management and adopt a successful system vision. As such, and with illustrations coming from many various fields (aviation, fishing, nuclear, oil, medicine), it potentially covers a broad readership.

  7. Tract-Specific Analyses of Diffusion Tensor Imaging Show Widespread White Matter Compromise in Autism Spectrum Disorder

    Science.gov (United States)

    Shukla, Dinesh K.; Keehn, Brandon; Muller, Ralph-Axel

    2011-01-01

    Background: Previous diffusion tensor imaging (DTI) studies have shown white matter compromise in children and adults with autism spectrum disorder (ASD), which may relate to reduced connectivity and impaired function of distributed networks. However, tract-specific evidence remains limited in ASD. We applied tract-based spatial statistics (TBSS)…

  8. Integrated digital superconducting logic circuits for the quantum synthesizer. Report

    International Nuclear Information System (INIS)

    Buchholz, F.I.; Kohlmann, J.; Khabipov, M.; Brandt, C.M.; Hagedorn, D.; Balashov, D.; Maibaum, F.; Tolkacheva, E.; Niemeyer, J.

    2006-11-01

    This report presents the results, which were reached in the framework of the BMBF cooperative plan ''Quantum Synthesizer'' in the partial plan ''Integrated Digital Superconducting Logic Circuits''. As essential goal of the plan a novel instrument on the base of quantum-coherent superconducting circuits should be developed. which allows to generate praxis-relevant wave forms with quantum accuracy, the quantum synthesizer. The main topics of development of the reported partial plan lied at the one hand in the development of integrated, digital, superconducting circuit in rapid-single-flux (RSFQ) quantum logics for the pattern generator of the quantum synthesizer, at the other hand in the further development of the fabrication technology for the aiming of high circuit complexity. In order to fulfil these requirements at the PTB a new design system was implemented, based on the software of Cadence. Together with the required RSFQ extensions for the design of digital superconducting circuits was a platform generated, on which the reachable circuit complexity is exclusively limited by the technology parameters of the available fabrication technology: Physical simulations are with PSCAN up to a complexity of more than 1000 circuit elements possible; furthermore VHDL allows the verification of arbitrarily large circuit architectures. In accordance for this the production line at the PTB was brought to a level, which allows in Nb/Al-Al x O y /Nb SIS technology implementation the fabrication of highly integrable RSFQ circuit architectures. The developed and fabricated basic circuits of the pattern generator have proved correct functionality and reliability in the measuring operation. Thereby for the circular RSFQ shift registers a key role as local memories in the construction of the pattern generator is devolved upon. The registers were realized with the aimed bit lengths up to 128 bit and with reachable signal-processing speeds of above 10 GHz. At the interface RSFQ

  9. Left Ventricular Gene Expression Profile of Healthy and Cardiovascular Compromised Rat Models Used in Air Pollution Studies

    Science.gov (United States)

    The link between pollutant exposure and cardiovascular disease (CVD) has prompted mechanistic research with animal models of CVD. We hypothesized that the cardiac gene expression patterns of healthy and genetically compromised, CVD-prone rat models, with or without metabolic impa...

  10. Results of endoscopic surgery and intralesional steroid therapy for airway compromise due to tracheobronchial Wegener's granulomatosis

    Directory of Open Access Journals (Sweden)

    S. A. R. Nouraei

    2008-04-01

    Full Text Available Background: Upper airway compromise due to tracheobronchial stenosis commonly occurs in patients with Wegener's Granulomatosis (WG. There is at present no consensus on the optimal management of this life-threatening condition. Objective: To assess the results of laryngo-tracheo-bronchoscopy, intralesional steroid therapy, laser surgery, and dilatation in managing obstructive tracheobronchial WG. Methods: Records of eighteen previously-untreated stridulous patients with obstructive tracheobronchial WG, treated between 2004 and 2006 were prospectively recorded on an airway database and retrospectively reviewed. Information about patient and lesion characteristics and treatment details were recorded. Treatment progress was illustrated using a timeline plot, and intervention-free intervals were calculated with actuarial analysis. Results: There were nine males and the average age at presentation was 40 (16 years [range 13–74]. There were thirteen patients with tracheal, and five patients with tracheal and bronchial lesions. The average tracheal lesion height was 8 (3 mm, located 23 (9 mm below the glottis. There were 1, 10 and 7 Myer-Cotton grade I, II and III lesions respectively. Mean intervention-free interval following minimally-invasive treatment was 26 (2.8 months. Following endobronchial therapy the median intervention-free interval was 22 months (p>0.8 vs. tracheal lesions. No patient required a tracheostomy or endoluminal stenting. Conclusions: Intralesional steroid therapy and conservative endoluminal surgery is an effective strategy for treating airway compromise due to active tracheal and bronchial WG, obviating the need for airway bypass or stenting. We recommend the combination of endotracheal dilatation, conservative laser surgery and steroid therapy as the standard of care for treating airway compromise due to obstructive tracheobronchial WG.

  11. Commonly Employed African Neonatal Skin Care Products Compromise Epidermal Function in Mice.

    Science.gov (United States)

    Man, Mao-Qiang; Sun, Richard; Man, George; Lee, Dale; Hill, Zelee; Elias, Peter M

    2016-09-01

    Neonatal mortality is much higher in the developing world than in developed countries. Infections are a major cause of neonatal death, particularly in preterm infants, in whom defective epidermal permeability barrier function facilitates transcutaneous pathogen invasion. The objective was to determine whether neonatal skin care products commonly used in Africa benefit or compromise epidermal functions in murine skin. After twice-daily treatment of 6- to 8-week-old hairless mice with each skin care product for 3 days, epidermal permeability barrier function, skin surface pH, stratum corneum hydration, and barrier recovery were measured using a multiprobe adapter system physiology monitor. For products showing some benefits in these initial tests, the epidermal permeability barrier homeostasis was assessed 1 and 5 hours after a single application to acutely disrupted skin. All of the skin care products compromised basal permeability barrier function and barrier repair kinetics. Moreover, after 3 days of treatment, most of the products also reduced stratum corneum hydration while elevating skin surface pH to abnormal levels. Some neonatal skin care products that are widely used in Africa perturb important epidermal functions, including permeability barrier homeostasis in mice. Should these products have similar effects on newborn human skin, they could cause a defective epidermal permeability barrier, which can increase body fluid loss, impair thermoregulation, and contribute to the high rates of neonatal morbidity and mortality seen in Africa. Accordingly, alternative products that enhance permeability barrier function should be identified, particularly for use in preterm infants. © 2016 Wiley Periodicals, Inc.

  12. Consequences of early extraction of compromised first permanent molar: a systematic review.

    Science.gov (United States)

    Saber, Afnan M; Altoukhi, Doua H; Horaib, Mariam F; El-Housseiny, Azza A; Alamoudi, Najlaa M; Sabbagh, Heba J

    2018-04-05

    The aim of this study was to systematically review the literature to determine the sequelae of early extraction of compromised first permanent molars (FPMs) with regard to the skeletal and dental development of 5- to 15-year-old children. Meta-analysis was conducted when applicable. Our research protocol included a search strategy, inclusion/exclusion criteria, and a data extraction plan. The search engines used were PubMed, Scopus, and Science Direct. Study selection was performed independently by three reviewers. Articles published from 1960 to 2017 were reviewed based on inclusion and exclusion criteria. Meta-analysis was performed to compare space closure between upper and lower arches. Eleven studies fulfilled the inclusion criteria. The consequences were decrease in post extraction space, accelerated development and eruption of second permanents molars (SPMs) and third molars, a decrease in caries and/or fillings on the proximal surfaces of adjacent teeth, lingual tipping and retrusion of incisors, and counter clockwise rotation of the occlusal plane. There were several consequences of early extraction of FPMs, which were related to skeletal and dental development. Our systematic review suggests that comprehensive evaluation of the compromised FPMs should be performed before planning an extraction. The ideal time for FPM extraction is when the SPM is at the early bifurcation stage in order to achieve complete closure of the extraction space by the SPM. Benefits should be weighed over the risks to decrease the risk of unfavorable outcomes as much as possible. However, due to the limited evidence on the outcomes and variables that influence them, high-quality prospective studies are needed.

  13. Compromised Global and Regional Cerebral Blood Flow in Congestive Heart Failure

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J. S.; Kim, J. J.; Im, K. C.; Moon, D. H. [College of Medicine, Univ. of Ulsan, Seoul (Korea, Republic of)

    2003-07-01

    It has been known that cerebral perfusion is maintained in patients with congestive heart failure (CHF) by a complex series of compensatory mechanisms. However cognitive impairment is a common problem experienced by patients with CHF and may result from deranged cerebral perfusion. We prospectively investigated the global and regional CBF of patients with CHF and compared the results with that of normal controls. Thirty two patients (M/F: 22/10, 4211 yr) with CHF (LVEF=218.1%) and 10 healthy controls (M/F: 6/4, 398 yr) were prospectively studied. No patients had cerebrovascular disease or other disease affecting cognitive function. All patients and normal controls underwent radionuclide angiography including cerebral hemispheres and aortic arch, and brain perfusion SPECT using Tc-99m ECD. Global CBF was measured non-invasively by the application of Patlak plot graphical analysis. Quantitative rCBF images were obtained from SPECT image using global CBF values, regional/global count ratios, and Lassen's linearization correction algorithm. Difference of regional CBF between CHF and normal control were assessed using a SPM99 without global count normalization (uncorrected p<0.0001, extent threshold>100 voxels). Global CBF (41.54.7 ml/min/100g) of the patients with CHF were significantly lower than those (49.15.7 ml/min/100g) of controls (p<0.001). Regional CBF was significantly decreased in frontal, temporal and parietal neocortex of both cerebral hemispheres compared to normal controls. Regional rCBF of basal ganglia, thalamus, and brain stem were preserved, even though global CBF was variably compromised. Our study show that global CBF is significantly decreased in CHF and regional CBF of frontal, parietal and temporal neocortex is compromised preferentially. Further studies would be needed to investigate the relationship of rCBF change and cognitive impairment in patients with CHF.

  14. β-Cell Ca(2+) dynamics and function are compromised in aging.

    Science.gov (United States)

    Barker, Christopher J; Li, Luosheng; Köhler, Martin; Berggren, Per-Olof

    2015-01-01

    Defects in pancreatic β-cell function and survival are key components in type 2 diabetes (T2D). An age-dependent deterioration in β-cell function has also been observed, but little is known about the molecular mechanisms behind this phenomenon. Our previous studies indicate that the regulation of cytoplasmic free Ca(2+) concentration ([Ca(2+)]i) may be critical and that this is dependent on the proper function of the mitochondria. The [Ca(2+)]i dynamics of the pancreatic β-cell are driven by an interplay between glucose-induced influx of extracellular Ca(2+) via voltage-dependent Ca(2+) channels and the inositol 1,4,5-trisphosphate (Ins(1,4,5)P3)-mediated liberation of Ca(2+) from intracellular stores. Our previous work has indicated a direct relationship between disruption of Ins(1,4,5)P3-mediated Ca(2+) regulation and loss of β-cell function, including disturbed [Ca(2+)]i dynamics and compromised insulin secretion. To investigate these processes in aging we used three mouse models, a premature aging mitochondrial mutator mouse, a mature aging phenotype (C57BL/6) and an aging-resistant phenotype (129). Our data suggest that age-dependent impairment in mitochondrial function leads to modest changes in [Ca(2+)]i dynamics in mouse β-cells, particularly in the pattern of [Ca(2+)]i oscillations. These changes are driven by modifications in both PLC/Ins(1,4,5)P3-mediated Ca(2+) mobilization from intracellular stores and decreased β-cell Ca(2+) influx over the plasma membrane. Our findings underscore an important concept, namely that even relatively small, time-dependent changes in β-cell signal-transduction result in compromised insulin release and in a diabetic phenotype. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Space reactor electric systems: system integration studies, Phase 1 report

    International Nuclear Information System (INIS)

    Anderson, R.V.; Bost, D.; Determan, W.R.; Harty, R.B.; Katz, B.; Keshishian, V.; Lillie, A.F.; Thomson, W.B.

    1983-01-01

    This report presents the results of preliminary space reactor electric system integration studies performed by Rockwell International's Energy Systems Group (ESG). The preliminary studies investigated a broad range of reactor electric system concepts for powers of 25 and 100 KWe. The purpose of the studies was to provide timely system information of suitable accuracy to support ongoing mission planning activities. The preliminary system studies were performed by assembling the five different subsystems that are used in a system: the reactor, the shielding, the primary heat transport, the power conversion-processing, and the heat rejection subsystems. The subsystem data in this report were largely based on Rockwell's recently prepared Subsystem Technology Assessment Report. Nine generic types of reactor subsystems were used in these system studies. Several levels of technology were used for each type of reactor subsystem. Seven generic types of power conversion-processing subsystems were used, and several levels of technology were again used for each type. In addition, various types and levels of technology were used for the shielding, primary heat transport, and heat rejection subsystems. A total of 60 systems were studied

  16. World Small Hydropower Development Report

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Heng; Esser, Lara [ICSGP (China); Masera, Diego [UNIDO, Vienna (Austria)

    2013-07-01

    Currently, small hydropower plants with a capacity of 10 MW, exist in 148 countries or territories worldwide. Four other countries have been identified with resource potential. This report aims to identify the development status and resource potential of small hydro in various countries, territories and regions throughout the world. Working with experts at the ground level to compile and share existing information, experiences and challenges, one comprehensive report was created. Decision-makers, stakeholders and potential investors clearly need this comprehensive information to more effectively promote small hydropower as a renewable and rural energy source for sustainable development and to overcome the existing development barriers. The findings of this report show that small hydropower potential globally is approximated at almost 173 GW. The figure is arrived by totaling data from a wide range of sources with potential compromise of data integrity to varying degrees. For example, research data on economically feasible potential were more readily available in developed countries than those in the least developed or developing countries. More than half of the world's known hydropower potential is located in Asia, around one third can be found in Europe and the Americas. It is possible in the future that more small hydropower potential might be identified both on the African and American continents. The installed small hydropower capacity (up to 10 MW) is estimated to be 75 GW in 2011/2012. The report provides detailed data for each country/region, including recommendations on the national, regional and international level.

  17. World Small Hydropower Development Report

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Heng; Esser, Lara (ICSGP (China)); Masera, Diego (UNIDO, Vienna (Austria))

    2013-07-01

    Currently, small hydropower plants with a capacity of 10 MW, exist in 148 countries or territories worldwide. Four other countries have been identified with resource potential. This report aims to identify the development status and resource potential of small hydro in various countries, territories and regions throughout the world. Working with experts at the ground level to compile and share existing information, experiences and challenges, one comprehensive report was created. Decision-makers, stakeholders and potential investors clearly need this comprehensive information to more effectively promote small hydropower as a renewable and rural energy source for sustainable development and to overcome the existing development barriers. The findings of this report show that small hydropower potential globally is approximated at almost 173 GW. The figure is arrived by totaling data from a wide range of sources with potential compromise of data integrity to varying degrees. For example, research data on economically feasible potential were more readily available in developed countries than those in the least developed or developing countries. More than half of the world's known hydropower potential is located in Asia, around one third can be found in Europe and the Americas. It is possible in the future that more small hydropower potential might be identified both on the African and American continents. The installed small hydropower capacity (up to 10 MW) is estimated to be 75 GW in 2011/2012. The report provides detailed data for each country/region, including recommendations on the national, regional and international level.

  18. Enhanced susceptibility to predation in corals of compromised condition

    Directory of Open Access Journals (Sweden)

    Allan J. Bright

    2015-09-01

    Full Text Available The marine gastropod, Coralliophila abbreviata, is an obligate corallivore that causes substantial mortality in Caribbean Acropora spp. Considering the imperiled status of Acropora cervicornis and A. palmata, a better understanding of ecological interactions resulting in tissue loss may enable more effective conservation strategies. We examined differences in susceptibility of A. cervicornis to C. abbreviata predation based on coral tissue condition. Coral tissue condition was a strong determinant of snail prey choice, with snails preferring A. cervicornis fragments that were diseased or mechanically damaged over healthy fragments. In addition, snails always chose fragments undergoing active predation by another snail, while showing no preference for a non-feeding snail when compared with an undisturbed prey fragment. These results indicate that the condition of A. cervicornis prey influenced foraging behavior of C. abbreviata, creating a potential feedback that may exacerbate damage from predation in coral populations compromised by other types of disturbance.

  19. EPA Issues November 15, 2010 Memorandum: Integrated Reporting and Listing Decisions Related to Ocean Acidification

    Science.gov (United States)

    The memorandum provides information to assist regions and states in preparing and reviewing Integrated Reports related to ocean acidification (OA) impacts under Sections 303(d), 305(b) and 314 of the Clean Water Act (CWA).

  20. Operational test report for LERF Basin 242AL-44 integrity test

    International Nuclear Information System (INIS)

    Galioto, T.M.

    1994-01-01

    This operational test report documents the results of LERF operational testing per operational test procedure (OTP) TFPE-WP-0231, ''LERF Basin Integrity Testing.'' The primary purpose of the OTP was to resolve test exceptions generated as a result of TFPE-WP-0184. The TOP was prepared and performed in accordance with WHC-SD-534-OTP-002, ''Operational Test Plan for the 242-A Evaporator Upgrades and the Liquid Effluent Retention Facility.'' WHC-S-086, ''Specification for Operational Testing of the Liquid Effluent Retention Facility, Basin Integrity Testing,'' identified the test requirements and acceptance criteria. The completed, signed-off test procedure is contained in Appendix A. The test log is contained in Appendix B. Section 2.1 describes all the test exceptions written during performance of the Operational Test Procedure. The test revisions generated during the testing are discussed in Section 2.2. The dispositioned test exception forms are contained in Appendix C

  1. Compromised epidermal barrier stimulates Harderian gland activity and hypertrophy in ACBP-/- mice

    DEFF Research Database (Denmark)

    Sørensen, Signe Bek; Neess, Ditte; Dixen, Karen

    2015-01-01

    of the eye lid. We show that disruption of the Acbp gene leads to a significant enlargement of this gland with hypertrophy of the acinar cells and increased de novo synthesis of monoalkyl diacylglycerol, the main lipid species produced by the gland. Mice with conditional targeting of the Acbp gene......Acyl-CoA binding protein (ACBP) is a small, ubiquitously expressed intracellular protein that binds C14-C22 acyl-CoA esters with very high affinity and specificity. We have recently shown that targeted disruption of the Acbp gene leads to a compromised epidermal barrier and that this causes delayed...

  2. MHD Technology Transfer, Integration and Review Committee. Seventh semi-annual status report, April 1991--September 1991

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-01

    This seventh semi-annual status report of the MHD Technology Transfer, Integration and Review Committee (TTIRC) summarizes activities of the TTIRC during the period April 1991 through September 1991. It includes a summary and minutes of the General Committee meeting, progress summaries of ongoing POC contracts, discussions pertaining to technical integration issues in the POC program, and planned activities for the next six months. The meeting included test plan with Western coal, seed regeneration economics, power management for the integrated topping cycle and status of the Clean Coal Technology Proposal activities. Appendices cover CDIF operations HRSR development, CFFF operations etc.

  3. HyPEP FY-07 Report: System Integration Model Development

    Energy Technology Data Exchange (ETDEWEB)

    C. H. Oh; E. S. Kim; S. R. Sherman; R. Vilim

    2007-04-01

    The integrated system of a Very High Temperature Gas-Cooled Reactor (VHTR) and a High Temperature Steam Electrolysis (HTSE) process is one of systems being investigated by the U.S. Department of Energy and Idaho National Laboratory. This system will produce hydrogen by utilizing a highly efficient VHTR with an outlet temperature of 900 °C and supplying necessary energy and electricity to the HTSE process for electrolysis of high temperature steam. This report includes a description of five configurations including an indirect parallel cycle, an indirect serial cycle, a direct serial cycle, a steam combined cycle, and a reheat cycle. HYSYS simulations were performed for each of these configurations coupled to a HTSE process. Final results are presented along with parametric studies and process optimization.

  4. 'Compromise position' image alignment to accommodate independent motion of multiple clinical target volumes during radiotherapy: A high risk prostate cancer example

    International Nuclear Information System (INIS)

    Rosewall, Tara; Alasti, Hamideh; Bayley, Andrew; Yan, Jing

    2017-01-01

    Inclusion of multiple independently moving clinical target volumes (CTVs) in the irradiated volume causes an image guidance conundrum. The purpose of this research was to use high risk prostate cancer as a clinical example to evaluate a 'compromise' image alignment strategy. The daily pre-treatment orthogonal EPI for 14 consecutive patients were included in this analysis. Image matching was performed by aligning to the prostate only, the bony pelvis only and using the 'compromise' strategy. Residual CTV surrogate displacements were quantified for each of the alignment strategies. Analysis of the 388 daily fractions indicated surrogate displacements were well-correlated in all directions (r 2 = 0.95 (LR), 0.67 (AP) and 0.59 (SI). Differences between the surrogates displacements (95% range) were −0.4 to 1.8 mm (LR), −1.2 to 5.2 mm (SI) and −1.2 to 5.2 mm (AP). The distribution of the residual displacements was significantly smaller using the 'compromise' strategy, compared to the other strategies (p 0.005). The 'compromise' strategy ensured the CTV was encompassed by the PTV in all fractions, compared to 47 PTV violations when aligned to prostate only. This study demonstrated the feasibility of a compromise position image guidance strategy to accommodate simultaneous displacements of two independently moving CTVs. Application of this strategy was facilitated by correlation between the CTV displacements and resulted in no geometric excursions of the CTVs beyond standard sized PTVs. This simple image guidance strategy may also be applicable to other disease sites that concurrently irradiate multiple CTVs, such as head and neck, lung and cervix cancer.

  5. Development of a conceptual framework toward an integrated transportation system : final report, April 10, 2009.

    Science.gov (United States)

    2009-04-10

    This report documents research on the conceptual framework of an integrated transportation system with a prototype application under the framework. Three levels of control are involved in this framework: at the global level (an entire transportation ...

  6. Managing forest and marginal agricultural land for multiple tradeoffs : compromising on economic, carbon and structural biodiversity objectives

    NARCIS (Netherlands)

    Krcmar, E.; Kooten, van G.C.; Vertinsky, I.

    2005-01-01

    In this paper, we use compromise programming to solve a multiple-objective land use and forest management planning model. Long- and short- (`fast¿) term carbon uptake, maintenance of structural diversity, and economic (net returns to forestry and agriculture) objectives are simultaneously achieved

  7. THE IMPACT OF THE BUSINESS AND ORGANIZATIONAL SIZE OF A COMPANY ALONG WITH GRI AND CSR ADOPTION ON INTEGRATING SUSTAINABILITY REPORTING PRACTICES

    Directory of Open Access Journals (Sweden)

    Tiron-Tudor Adriana

    2012-07-01

    Full Text Available This paper intends to investigate the correlation between the business and organizational size of companies as well as GRI and CSR practices adoption, and the level of sustainability disclosure. The correlation is highlighted through SPSS statistic analysis and determination of an econometric model between a dependent variable - sustainability information disclosure - and five independent ones- sales, number of employees, GRI and CSR policies and ultimately reporting period/year -. We use the Deloitte Sustainability Scorecard for measuring the sustainability reporting practices. Our sample comprises companies that adopted integrated reporting for the period 2009-2010. Sample selection was made on the basis that sustainability reports are incorporated within the integrated reports. We assume to obtain a high correlation between the business and organizational size of companies, GRI and/or CSR polities and the level of sustainability information disclosed in our integrated reports.

  8. Integrated reporting with CSR practices

    DEFF Research Database (Denmark)

    Lueg, Klarissa; Lueg, Rainer; Andersen, Karina

    2016-01-01

    : We find that the family-owned EGE follows a strategy of “enlightened shareholder value”, in which CSR is an essential value driver. This strategy fostered IR with guidelines and standards for CSR. The CSR practices appeared to be helpful for integrating measureable plans to the strategy...

  9. Which Statistic Should Be Used to Detect Item Preknowledge When the Set of Compromised Items Is Known?

    Science.gov (United States)

    Sinharay, Sandip

    2017-09-01

    Benefiting from item preknowledge is a major type of fraudulent behavior during educational assessments. Belov suggested the posterior shift statistic for detection of item preknowledge and showed its performance to be better on average than that of seven other statistics for detection of item preknowledge for a known set of compromised items. Sinharay suggested a statistic based on the likelihood ratio test for detection of item preknowledge; the advantage of the statistic is that its null distribution is known. Results from simulated and real data and adaptive and nonadaptive tests are used to demonstrate that the Type I error rate and power of the statistic based on the likelihood ratio test are very similar to those of the posterior shift statistic. Thus, the statistic based on the likelihood ratio test appears promising in detecting item preknowledge when the set of compromised items is known.

  10. European wind power integration study. Periodic report 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-12-31

    This periodic report no. 1 describes the work done in the Danish part of the European Wind Power Integration Study in the period until 1.4.1991. The R and D project was initiated January 1, 1989 upon prior establishment of registration equipment at 7 wind farms and at the Tjaereborg turbine. ELSAM and the meteorological service centre in Karup (VTC-Karup) have supplied data for the task. Wind Predictability, Potential and Benefits, Wind Farm - Grid Interface, Distribution System Strength, Wind Farm Cost and Operation, and Co-generation Wind Turbines/Other renewables were measured and modelled. The statistical distribution of the wind speed variations (changes in wind speed from one period of time to another) has been established with great certainty in the report. The wind speed variations follow a Weibull distribution, irrespective of the time intervals with which the data are considered. Duration curves and power distributions for the 7 wind farms have been estimated. Registration equipment for one-minute measurements was chosen in order to clarify the short-term variations in the wind power production. The possibility of working out production forecasts, to be applied in the daily load dispatching, were to be assessed for the total amount of wind power production in Jutland and Funen. The report has examined whether it would be possible to have only one wind measurement and then let it be `guiding` for the total wind farm production. Some simulations are to be carried out in the attempt to set up guidelines for the connection between the strength of distribution systems and the requirements which must be made to the wind farms which are to be places in the system. (EG)

  11. Coordinating for Arctic Conservation: Implementing Integrated Arctic Biodiversity Monitoring, Data Management and Reporting

    Science.gov (United States)

    Gill, M.; Svoboda, M.

    2012-12-01

    Arctic ecosystems and the biodiversity they support are experiencing growing pressure from various stressors (e.g. development, climate change, contaminants, etc.) while established research and monitoring programs remain largely uncoordinated, lacking the ability to effectively monitor, understand and report on biodiversity trends at the circumpolar scale. The maintenance of healthy arctic ecosystems is a global imperative as the Arctic plays a critical role in the Earth's physical, chemical and biological balance. A coordinated and comprehensive effort for monitoring arctic ecosystems is needed to facilitate effective and timely conservation and adaptation actions. The Arctic's size and complexity represents a significant challenge towards detecting and attributing important biodiversity trends. This demands a scaled, pan-arctic, ecosystem-based approach that not only identifies trends in biodiversity, but also identifies underlying causes. It is critical that this information be made available to generate effective strategies for adapting to changes now taking place in the Arctic—a process that ultimately depends on rigorous, integrated, and efficient monitoring programs that have the power to detect change within a "management" time frame. To meet these challenges and in response to the Arctic Climate Impact Assessment's recommendation to expand and enhance arctic biodiversity monitoring, the Conservation of Arctic Flora and Fauna (CAFF) Working Group of the Arctic Council launched the Circumpolar Biodiversity Monitoring Program (CBMP). The CBMP is led by Environment Canada on behalf of Canada and the Arctic Council. The CBMP is working with over 60 global partners to expand, integrate and enhance existing arctic biodiversity research and monitoring efforts to facilitate more rapid detection, communication and response to significant trends and pressures. Towards this end, the CBMP has established three Expert Monitoring Groups representing major Arctic

  12. Self-reported Improvement in Side Effects and Quality of Life With Integrative Medicine in Breast Cancer Patients.

    Science.gov (United States)

    Hack, Carolin C; Hackl, Janina; Hüttner, Nina B M; Langemann, Hanna; Schwitulla, Judith; Dietzel-Drentwett, Svenja; Fasching, Peter A; Beckmann, Matthias W; Theuser, Anna-Katharin

    2018-05-01

    Although the demand from patients for integrative medicine is increasing, complementary medicine services are still quite heterogeneous and have not been incorporated into clinical routine. The aim of this study was to systematically evaluate improvements in side effects and quality of life associated with a hospital-based integrative medicine program in the modern breast cancer patient care setting. In a cross-sectional study, integrative health counseling and treatment were evaluated in women with breast cancer. Over a 15-month period, data for 75 patients from an integrative medicine consultancy service with standardized operating procedures were collected at the University Breast Center for Franconia. At baseline, the patients answered a questionnaire on their medical history, symptoms, and the treatment goals they were hoping to achieve with integrative medicine. In the follow-up, patient-reported outcomes related to side effects of conventional cancer treatment and patients' quality of life were analyzed. Among 60 patients with the therapy goal of reducing the side effects of conventional treatment, 46 (76.7%) were successful. Among 57 patients hoping to improve disease-related quality of life, 46 (82%) reported success. Whereas patients with metastatic disease achieved a reduction in the side effects of conventional therapy, quality-of-life improvements were predominantly achieved by patients with a good treatment prognosis. Breast cancer patients benefit from the counseling and treatment provided with integrative medicine in all phases of tumor disease. Integrative treatment services should be included as part of patient care in clinical routine work to offer patients the maximum quality of care and safety with complementary therapies.

  13. Integrating Neuropsychology and Brain Imaging for a Referral of Possible Pseudodementia: A Case Report

    OpenAIRE

    Tanner, J.J.; Mellott, E.; Dunne, E.M.; Price, C.C.

    2015-01-01

    We present the case of “CL,” a 65 year-old, right-handed, Caucasian female referred for a neuropsychological evaluation of memory difficulties and depression with the rule out of pseudodementia. Mood measures showed elevated depression and apathy symptoms. The neuropsychological profile showed variable effort, intact comprehension but compromised confrontation naming and verbal memory deficits. A brain magnetic resonance imaging (MRI) scan was conducted within 24 hours of the neuropsychology ...

  14. A pilot study for the integration of cytometry reports in digital cytology telemedicine applications.

    Science.gov (United States)

    Giansanti, Daniele; Cerroni, Fabio; Amodeo, Rachele; Filoni, Marco; Giovagnoli, Maria Rosaria

    2010-01-01

    Up to date, tele-pathology in the three different forms of application, "dynamic", "static" and "virtual microscopy" has been mainly based on tele-hystology remote consulting. Today the diffusion of specialized WAN connections is guiding the research of new applications of tele-pathology. A specific analysis has been conducted, focused on digital cytology, in the biomedical laboratory of Sant'Andrea Hospital to investigate the technologies potentially useful to integrate in the LAN/WAN for telemedicine applications. Among the possible tools useful to be integrated in the LAN/WAN for telemedicine applications, the cytometry equipment available in the technical unity of cytometry has been considered important. The study finally provides a proposal for a tele-consulting architecture for the integration of cytometry reports both in the hospital LAN and the WAN for possible cooperative diagnosis and second opinion support.

  15. A pilot study for the integration of cytometry reports in digital cytology telemedicine applications

    Directory of Open Access Journals (Sweden)

    Daniele Giansanti

    2010-06-01

    Full Text Available Up to date, tele-pathology in the three different forms of application, "dynamic", "static" and "virtual microscopy" has been mainly based on tele-hystology remote consulting. Today the diffusion of specialized WAN connections is guiding the research of new applications of tele-pathology. A specific analysis has been conducted, focused on digital cytology, in the biomedical laboratory of Sant'Andrea Hospital to investigate the technologies potentially useful to integrate in the LAN/WAN for telemedicine applications. Among the possible tools useful to be integrated in the LAN/WAN for telemedicine applications, the cytometry equipment available in the technical unity of cytometry has been considered important. The study finally provides a proposal for a tele-consulting architecture for the integration of cytometry reports both in the hospital LAN and the WAN for possible cooperative diagnosis and second opinion support.

  16. Annular pigment band on the posterior capsule following blunt ocular trauma: a case report

    Directory of Open Access Journals (Sweden)

    Harrison Rosalind J

    2005-06-01

    Full Text Available Abstract Background To report an unusual case of annular pigment band on the posterior capsule following blunt ocular trauma. Case presentation We describe an annular pigment band on the posterior capsule following blunt ocular trauma in a 28-year old male patient. Repeat examinations revealed no evidence of other signs of blunt ocular trauma or pigment dispersion syndrome in either eye. Conclusion The annular pigment band in this case corresponds to the adherence of the hyaloideocapsulare ligament to the posterior capsule and reconfirms its rare visualization in the living eye. This finding may be an isolated sign of blunt ocular trauma and a compromised integrity of the vitreolenticular interface should be strongly suspected. We recommend careful documentation in context of future cataract surgery in these eyes.

  17. 2015 Strategic Petroleum Reserve Bayou Choctaw Well Integrity Grading Report.

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, Barry L; Lord, David; Lord, Anna C. Snider; Bettin, Giorgia; Park, Byoung; Rudeen, D.K.; Eldredge, L.L.; Wynn, K.; Checkai, D.; Osborne, G.; Moore, D.

    2015-10-01

    This report summarizes the work performed in the prioritization of cavern access wells for remediation and monitoring at the Bayou Choctaw Strategic Petroleum Reserve site. The grading included consideration of all 15 wells at the Bayou Choctaw site, with each active well receiving a separate grade for remediation and monitoring. Numerous factors affecting well integrity were incorporated into the grading including casing survey results, cavern pressure history, results from geomechanical simulations, and site geologic factors. The factors and grading framework used here are the same as those used in developing similar well remediation and monitoring priorities at the Big Hill, Bryan Mound, and West Hackberry Strategic Petroleum Reserve Sites.

  18. 2015 Strategic Petroleum Reserve West Hackberry Well Integrity Grading Report.

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, Barry L; Lord, David; Lord, Anna C. Snider; Bettin, Giorgia; Sobolik, Steven R.; Rudeen, David Keith; Eldredge, Lisa L. (FFPO); Wynn, Karen (FFPO); Checkai, Dean (FFPO); Osborne, Gerad (FFPO); Moore, Darryl (FFPO)

    2015-04-01

    This report summarizes the work performed in the prioritization of cavern access wells for remediation and monitoring at the West Hackberry Strategic Petroleum Reserve site. The grading included consideration of all 31 wells at the West Hackberry site, with each well receiving a separate grade for remediation and monitoring. Numerous factors affecting well integrity were incorporated into the grading including casing survey results, cavern pressure history, results from geomechanical simulations, and site geologic factors. The factors and grading framework used here are the same as those used in developing similar well remediation and monitoring priorities at the Big Hill and Bryan Mound Strategic Petroleum Reserve Sites.

  19. Neglecting legumes has compromised human health and sustainable food production.

    Science.gov (United States)

    Foyer, Christine H; Lam, Hon-Ming; Nguyen, Henry T; Siddique, Kadambot H M; Varshney, Rajeev K; Colmer, Timothy D; Cowling, Wallace; Bramley, Helen; Mori, Trevor A; Hodgson, Jonathan M; Cooper, James W; Miller, Anthony J; Kunert, Karl; Vorster, Juan; Cullis, Christopher; Ozga, Jocelyn A; Wahlqvist, Mark L; Liang, Yan; Shou, Huixia; Shi, Kai; Yu, Jingquan; Fodor, Nandor; Kaiser, Brent N; Wong, Fuk-Ling; Valliyodan, Babu; Considine, Michael J

    2016-08-02

    The United Nations declared 2016 as the International Year of Pulses (grain legumes) under the banner 'nutritious seeds for a sustainable future'. A second green revolution is required to ensure food and nutritional security in the face of global climate change. Grain legumes provide an unparalleled solution to this problem because of their inherent capacity for symbiotic atmospheric nitrogen fixation, which provides economically sustainable advantages for farming. In addition, a legume-rich diet has health benefits for humans and livestock alike. However, grain legumes form only a minor part of most current human diets, and legume crops are greatly under-used. Food security and soil fertility could be significantly improved by greater grain legume usage and increased improvement of a range of grain legumes. The current lack of coordinated focus on grain legumes has compromised human health, nutritional security and sustainable food production.

  20. IT risk management disclosure in the integrated reports of the top 40 listed companies on the JSE limited

    Directory of Open Access Journals (Sweden)

    Ben Marx

    2017-07-01

    Full Text Available Information Technology (IT has become an integral part of virtually all modern day organisations. The advent of IT has given rise to numerous benefits which increase productivity and efficiency in the workplace, however, IT also brings with it significant risks that can have an impact on an organisation’s ability to function as a going concern. Organisations, especially those listed on the Johannesburg Stock Exchange (JSE, are required to submit an Integrated Report (IR on an annual basis in which they indicate how they used the resources at their disposal to create value for the organisation and its stakeholders during the year under review. The IR is also a forward-looking document, as opposed to the traditional, backward-looking reports. The purpose of this paper is to determine to what extent IT Risk and IT Risk Management are disclosed in the IR’s of the Top 40 Listed Companies on the JSE. It further aims to determine whether IT Risks are included as material risk in the entity’s risk statements of the Integrated Report, and whether proper explanations are provided on how the materiality of the risks are determined and dealt with. This is done by means of an empirical study consisting of a content analysis of the IRs of the Top 40 listed companies on the JSE. The results of the analysis indicates that more than half of the companies included IT risk as part of their material risks and outlined appropriate and detailed processes that were followed by the company to manage those IT risks. The findings of the study accordingly support the need for communicating significant risks and the management thereof to stakeholders as part of the integrated nature of governance of entities. However, it is disconcerting that some companies are not doing this, and accordingly are not realising the need for communicating significant matters to their stakeholders and the value that informative and credible reporting will bring to an entity

  1. Sterilization of freeze dried manila clam (Ruditapea philippinarum) porridge for immuno-compromised patients

    Energy Technology Data Exchange (ETDEWEB)

    Song, Beom Seok; Park, Jae Nam [Team for Radiation Food Science and Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup (Korea, Republic of)

    2017-02-15

    This study was conducted to evaluate the combined effect of gamma irradiation and different conditions (vacuum packaging, antioxidant and freezing) on the microbiological and sensory characteristics of freeze dried Manila clam porridge (MCP) for immuno-compromised patient food. McP can be sterilized at 1 kGy to 10 kGy. the initial counts of total aerobic bacteria and yeast molds in the non-irradiated MCP were 2.4±0.5 and 1.2±0.3 log CFU g{sup -}'1, respectively, but gamma irradiation significantly decreased the total aerobic bacteria to below the detection limit (1 log CFU g{sup -1}) (5 kGy). Moreover, gamma irradiation effectively eliminated yeasts/molds at dose below than 1 kGy. However, gamma irradiation accelerated the increase of lipid oxidation and therefore, decreased the sensory characteristics of MCP as irradiation dose increased. to improve the sensory qualities of gamma irradiated MCP, combination treatment (vacuum packaging, 0.1% vitamin c) were applied. there was no significant difference in the overall acceptance scores between the combined-treatment sample (5.6 points) and the non-irradiated samples (6.0). the results indicate that combination treatment (vacuum packaging, 0.1% vitamin c) may help to maintain the quality of MCP. therefore, it considered that irradiation of MCP with combined treatment and this is an effective method for the consumption as a special purpose food such as for space travel or immuno-compromised patients.

  2. Sterilization of freeze dried manila clam (Ruditapea philippinarum) porridge for immuno-compromised patients

    International Nuclear Information System (INIS)

    Song, Beom Seok; Park, Jae Nam

    2017-01-01

    This study was conducted to evaluate the combined effect of gamma irradiation and different conditions (vacuum packaging, antioxidant and freezing) on the microbiological and sensory characteristics of freeze dried Manila clam porridge (MCP) for immuno-compromised patient food. McP can be sterilized at 1 kGy to 10 kGy. the initial counts of total aerobic bacteria and yeast molds in the non-irradiated MCP were 2.4±0.5 and 1.2±0.3 log CFU g"-'1, respectively, but gamma irradiation significantly decreased the total aerobic bacteria to below the detection limit (1 log CFU g"-"1) (5 kGy). Moreover, gamma irradiation effectively eliminated yeasts/molds at dose below than 1 kGy. However, gamma irradiation accelerated the increase of lipid oxidation and therefore, decreased the sensory characteristics of MCP as irradiation dose increased. to improve the sensory qualities of gamma irradiated MCP, combination treatment (vacuum packaging, 0.1% vitamin c) were applied. there was no significant difference in the overall acceptance scores between the combined-treatment sample (5.6 points) and the non-irradiated samples (6.0). the results indicate that combination treatment (vacuum packaging, 0.1% vitamin c) may help to maintain the quality of MCP. therefore, it considered that irradiation of MCP with combined treatment and this is an effective method for the consumption as a special purpose food such as for space travel or immuno-compromised patients

  3. Cerebral hematocrit decreases with hemodynamic compromise in carotid artery occlusion: a PET study.

    Science.gov (United States)

    Yamauchi, H; Fukuyama, H; Nagahama, Y; Katsumi, Y; Okazawa, H

    1998-01-01

    This study investigated whether in patients with internal carotid artery occlusion the regional cerebral hematocrit correlates with cerebral hemodynamics or metabolic state and, if so, how the regional cerebral hematocrit changes in the hemodynamically compromised region. We used positron emission tomography to study seven patients with unilateral internal carotid artery occlusion and no cortical infarction in the chronic stage. The distributions of red blood cell and plasma volumes were assessed using oxygen-15-labeled carbon monoxide and copper-62-labeled human serum albumin-dithiosemicarbazone tracers, respectively. The calculated hematocrit value was compared with the hemodynamic and metabolic parameters measured with the oxygen-15 steady-state technique. In the cerebral cortex, the value of the cerebral hematocrit varied but was correlated with the hemodynamic and metabolic status. Stepwise regression analysis revealed that the large vessel hematocrit, the cerebral metabolic rate of oxygen, and the cerebral blood flow or the oxygen extraction fraction accounted for a significant proportion of variance of the cerebral hematocrit. The oxygen extraction fraction and the cerebral metabolic rate of oxygen negatively correlated with the cerebral hematocrit, whereas the cerebral blood flow correlated positively: patients with reduced blood supply relative to metabolic demand (decreased blood flow with increased oxygen extraction fraction) showed low hematocrit values. In carotid artery occlusion in the chronic stage, regional cerebral hematocrit may vary according to cerebral hemodynamics and metabolic status. Regional cerebral hematocrit may decrease with hemodynamic compromise unless oxygen metabolism concomitantly decreases.

  4. Case Study: Converting Paper-based Case Report Forms to an Electronic Format (e-CRF) with ACASI Self-Report Integration.

    Science.gov (United States)

    Mierzwa, Stan; Souidi, Samir; Akello, Carolyne; Etima, Juliane; Ssebagala, Richard; Nolan, Monica; Kabwigu, Samuel; Nakablito, Clemensia

    2017-01-01

    This paper will discuss the integration of electronic Case Report Forms (e-CRFs) into an already existing Android-based Audio Computer-Assisted Self-Interview (ACASI) software solution that was developed for a public health project in Kampala, Uganda, the technical outcome results, and lessons learned that may be useful to other projects requiring or considering such a technology solution. The developed product can function without a connection to the Internet and allows for synchronizing collected data once connectivity is possible. Previously, only paper-based CRFs were utilized at the Uganda project site. A subset or select group of CRFs were targeted for integration with ACASI in order to test feasibility and success. Survey volume, error rate, and acceptance of the system, as well as the operational and technical design of the solution, will be discussed.

  5. Treatment of malpositioned periodontally compromised teeth by an interdisciplinary approach - A case report

    OpenAIRE

    Sonali Deshmukh; Sanket Agarkar; Amrita Kishore

    2009-01-01

    The traditional orthodontic patient-base of adolescents has changed dramatically over the last 20 years. Adult patients now comprise a very large percentage of the orthodontic patient base. These patients bring with them unique challenges to the provision of aesthetic treatment. Gingival aesthetics, for a long time the exclusive concern of the periodontist, has now become one of the chief aesthetic challenges presented to the practicing orthodontist. This report illustrates the interdisciplin...

  6. Establishment of normal gut microbiota is compromised under excessive hygiene conditions.

    Directory of Open Access Journals (Sweden)

    Bettina Schmidt

    Full Text Available BACKGROUND: Early gut colonization events are purported to have a major impact on the incidence of infectious, inflammatory and autoimmune diseases in later life. Hence, factors which influence this process may have important implications for both human and animal health. Previously, we demonstrated strong influences of early-life environment on gut microbiota composition in adult pigs. Here, we sought to further investigate the impact of limiting microbial exposure during early life on the development of the pig gut microbiota. METHODOLOGY/PRINCIPAL FINDINGS: Outdoor- and indoor-reared animals, exposed to the microbiota in their natural rearing environment for the first two days of life, were transferred to an isolator facility and adult gut microbial diversity was analyzed by 16S rRNA gene sequencing. From a total of 2,196 high-quality 16S rRNA gene sequences, 440 phylotypes were identified in the outdoor group and 431 phylotypes in the indoor group. The majority of clones were assigned to the four phyla Firmicutes (67.5% of all sequences, Proteobacteria (17.7%, Bacteroidetes (13.5% and to a lesser extent, Actinobacteria (0.1%. Although the initial maternal and environmental microbial inoculum of isolator-reared animals was identical to that of their naturally-reared littermates, the microbial succession and stabilization events reported previously in naturally-reared outdoor animals did not occur. In contrast, the gut microbiota of isolator-reared animals remained highly diverse containing a large number of distinct phylotypes. CONCLUSIONS/SIGNIFICANCE: The results documented here indicate that establishment and development of the normal gut microbiota requires continuous microbial exposure during the early stages of life and this process is compromised under conditions of excessive hygiene.

  7. Improved efficiency in clinical workflow of reporting measured oncology lesions via PACS-integrated lesion tracking tool.

    Science.gov (United States)

    Sevenster, Merlijn; Travis, Adam R; Ganesh, Rajiv K; Liu, Peng; Kose, Ursula; Peters, Joost; Chang, Paul J

    2015-03-01

    OBJECTIVE. Imaging provides evidence for the response to oncology treatment by the serial measurement of reference lesions. Unfortunately, the identification, comparison, measurement, and documentation of several reference lesions can be an inefficient process. We tested the hypothesis that optimized workflow orchestration and tight integration of a lesion tracking tool into the PACS and speech recognition system can result in improvements in oncologic lesion measurement efficiency. SUBJECTS AND METHODS. A lesion management tool tightly integrated into the PACS workflow was developed. We evaluated the effect of the use of the tool on measurement reporting time by means of a prospective time-motion study on 86 body CT examinations with 241 measureable oncologic lesions with four radiologists. RESULTS. Aggregated measurement reporting time per lesion was 11.64 seconds in standard workflow, 16.67 seconds if readers had to register measurements de novo, and 6.36 seconds for each subsequent follow-up study. Differences were statistically significant (p workflow-integrated lesion management tool, especially for patients with multiple follow-up examinations, reversing the onetime efficiency penalty at baseline registration.

  8. [A multi-measure analysis of the similarity, attraction, and compromise effects in multi-attribute decision making].

    Science.gov (United States)

    Tsuzuki, Takashi; Matsui, Hiroshi; Kikuchi, Manabu

    2012-12-01

    In multi-attribute decision making, the similarity, attraction, and compromise effects warrant specific investigation as they cause violations of principles in rational choice. In order to investigate these three effects simultaneously, we assigned 145 undergraduates to three context effect conditions. We requested them to solve the same 20 hypothetical purchase problems, each of which had three alternatives described along two attributes. We measured their choices, confidence ratings, and response times. We found that manipulating the third alternative had significant context effects for choice proportions and confidence ratings in all three conditions. Furthermore, the attraction effect was the most prominent with regard to choice proportions. In the compromise effect condition, although the choice proportion of the third alternative was high, the confidence rating was low and the response time was long. These results indicate that the relationship between choice proportions and confidence ratings requires further theoretical investigation. They also suggest that a combination of experimental and modeling studies is imperative to reveal the mechanisms underlying the context effects in multi-attribute, multi-alternative decision making.

  9. Content and Language Integrated Learning in the Netherlands: Teachers' Self-Reported Pedagogical Practices

    Science.gov (United States)

    van Kampen, Evelyn; Admiraal, Wilfried; Berry, Amanda

    2018-01-01

    In recent years, a surging uptake of content and language integrated learning (CLIL) has permeated the European context. This article presents the outcomes of a study about the self-reported pedagogical practices of CLIL teachers in the Netherlands. To investigate these teachers' pedagogies, a questionnaire was designed, validated and,…

  10. Arsenic promotes centrosome abnormalities and cell colony formation in p53 compromised human lung cells

    International Nuclear Information System (INIS)

    Liao Weiting; Lin Pinpin; Cheng, T.-S.; Yu, H.-S.; Chang, Louis W.

    2007-01-01

    Epidemiological evidence indicated that residents, especially cigarette smokers, in arseniasis areas had significantly higher lung cancer risk than those living in non-arseniasis areas. Thus, an interaction between arsenic and cigarette smoking in lung carcinogenesis was suspected. p53 dysfunction or mutation in lung epithelial cells was frequently observed in cigarette smokers. Our present study was to explore the differential effects by arsenic on H1355 cells (human lung adenocarcinoma cell line with mutation in p53), BEAS-2B (immortalized lung epithelial cell with functional p53) and pifithrin-α-treated BEAS-2B cells (p53-inhibited cells). These cells were treated with different doses of sodium arsenite (0, 0.1, 1, 5 and 10 μM) for 48 h. A greater reduction in cell viability was observed in the BEAS-2B cells vs. p53 compromised cells (H1355 or p53-inhibited BEAS-2B). Similar observation was also made on 7-day cell survival (growth) study. TUNEL analysis confirmed that there was indeed a significantly reduced arsenite-induced apoptosis found in p53-compromised cells. Centrosomal abnormality has been attributed to eventual chromosomal missegregation, aneuploidy and tumorigenesis. In our present study, reduced p21 and Gadd45a expressions and increased centrosomal abnormality (atopic and multiple centrosomes) were observed in both arsenite-treated H1355 and p53-inhibited BEAS-2B cells as compared with similarly treated BEAS-2B cells. Increased anchorage-independent growth (colony formation) of BEAS-2B cells co-treated with pifithrin-α and 5 μM sodium arsenite was also observed in soft agar. Our present investigation demonstrated that arsenic would act specifically on p53 compromised cells (either with p53 dysfunction or inhibited) to induce centrosomal abnormality and colony formation. These findings provided strong evidence on the carcinogenic promotional role of arsenic, especially under the condition of p53 dysfunction

  11. The effect of integrated reporting on integrated thinking between risk ...

    African Journals Online (AJOL)

    IIRC (2013b: 3), integrated thinking takes into account the connectivity and ... historical information and provides investors and other stakeholders with .... in the disclosure of risks and opportunities by using a sample of the top 100 JSE-.

  12. FY 2012 Lightweight Materials Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-04-15

    The FY 2012 Annual Progress Report for Lightweight Materials provides a detailed description of the activities and technical accomplishments which focuses on the development and validation of advanced materials and manufacturing technologies to significantly reduce light and heavy duty vehicle weight without compromising other attributes such as safety, performance, recyclability, and cost.

  13. Integrated Safety and Security Risk Assessment Methods: A Survey of Key Characteristics and Applications

    OpenAIRE

    Chockalingam, Sabarathinam; Hadziosmanovic, Dina; Pieters, Wolter; Teixeira, Andre; van Gelder, Pieter

    2017-01-01

    Over the last years, we have seen several security incidents that compromised system safety, of which some caused physical harm to people. Meanwhile, various risk assessment methods have been developed that integrate safety and security, and these could help to address the corresponding threats by implementing suitable risk treatment plans. However, an overarching overview of these methods, systematizing the characteristics of such methods, is missing. In this paper, we conduct a systematic l...

  14. Steam generator tube integrity program: Annual report, August 1995--September 1996. Volume 2

    International Nuclear Information System (INIS)

    Diercks, D.R.; Bakhtiari, S.; Kasza, K.E.; Kupperman, D.S.; Majumdar, S.; Park, J.Y.; Shack, W.J.

    1998-02-01

    This report summarizes work performed by Argonne National Laboratory on the Steam Generator Tube Integrity Program from the inception of the program in August 1995 through September 1996. The program is divided into five tasks: (1) assessment of inspection reliability, (2) research on ISI (inservice-inspection) technology, (3) research on degradation modes and integrity, (4) tube removals from steam generators, and (5) program management. Under Task 1, progress is reported on the preparation of facilities and evaluation of nondestructive evaluation techniques for inspecting a mock-up steam generator for round-robin testing, the development of better ways to correlate failure pressure and leak rate with eddy current (EC) signals, the inspection of sleeved tubes, workshop and training activities, and the evaluation of emerging NDE technology. Results are reported in Task 2 on closed-form solutions and finite-element electromagnetic modeling of EC probe responses for various probe designs and flaw characteristics. In Task 3, facilities are being designed and built for the production of cracked tubes under aggressive and near-prototypical conditions and for the testing of flawed and unflawed tubes under normal operating, accident, and severe-accident conditions. Crack behavior and stability are also being modeled to provide guidance for test facility design, develop an improved understanding of the expected rupture behavior of tubes with circumferential cracks, and predict the behavior of flawed and unflawed tubes under severe accident conditions. Task 4 is concerned with the acquisition of tubes and tube sections from retired steam generators for use in the other research tasks. Progress on the acquisition of tubes from the Salem and McGuire 1 nuclear plants is reported

  15. Tracheostomy in neurologically compromised paediatric patients: role of starplasty.

    Science.gov (United States)

    Gupta, A; Stokken, J; Krakovitz, P; Malhotra, P; Anne, S

    2015-10-01

    Starplasty tracheostomy is an alternative to traditional tracheostomy. This paper reviews neurologically compromised paediatric patients with tracheostomies and discusses the role of starplasty tracheostomy. A retrospective review was conducted of paediatric patients with a neurological disorder who underwent tracheostomy between 1997 and 2011. Forty-eight patients, with an average age of 7.3 years, were identified. The most common indications for tracheostomy were: ventilator dependence (39.6 per cent), an inability to tolerate secretions or recurrent aspiration pneumonia (33.3 per cent), and upper respiratory obstruction or hypotonia (12.5 per cent). The most common underlying neurological diagnosis was cerebral palsy. There were no early complications. Eighteen (43 per cent) of 42 patients with follow up experienced at least 1 delayed complication. Only 12 patients (28.6 per cent) were decannulated. Patients with primary neurological diagnoses have low rates of decannulation; starplasty tracheostomy should be considered for these patients. Patients with seizure disorder or acute neurological injury tended to have a higher short-term decannulation rate; traditional tracheostomy is recommended in these patients.

  16. Treatment of malpositioned periodontally compromised teeth by an interdisciplinary approach - A case report

    Directory of Open Access Journals (Sweden)

    Sonali Deshmukh

    2009-01-01

    Full Text Available The traditional orthodontic patient-base of adolescents has changed dramatically over the last 20 years. Adult patients now comprise a very large percentage of the orthodontic patient base. These patients bring with them unique challenges to the provision of aesthetic treatment. Gingival aesthetics, for a long time the exclusive concern of the periodontist, has now become one of the chief aesthetic challenges presented to the practicing orthodontist. This report illustrates the interdisciplinary approach in a patient requiring periodontic, orthodontic and prosthodontic treatment.

  17. Process integration and waste heat recovery in Lithuanian and Danish industry. Final report phase 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-08-01

    The present document forms the Final Report for the first phase of the project `Process Integration and Waste Heat Recovery in Lithuanian and Danish Industry`. The project is carried out in the period 1995-1998 in a co-operation between the COWI offices in Lyngby and Vilnius, The Technical University of Denmark (Institute for Energetics), Kaunas University of Technology (CIPAI) and Vilnius Technical University, financed by The Danish Ministry of Energy`s EFP-95-programme, Lithuanian Energy Agency as well as the participants. The first phase of the project has comprised the establishment of the CIPAI centre (Centre for Industrial Process Analysis and Integration) at Kaunas University of Technology, training and knowledge transfer as well as elaboration of 6 industrial case-studies within the area of `Process Integration and waste Heat Recovery`. The second phase of the project has comprised R and D activities in this area in order to present general conclusions from the project as well as to present new and improved methods and tools for PI-analysis. The aim of the Final Report for the first phase of the project is to summarise project activities and the achieved results from case-studies and from the operation of the CIPAI-centre in general. (au)

  18. Retrotracheal Extraskeletal Ewing's Sarcoma: Case Report and Discussion on Airway Management.

    Science.gov (United States)

    Van Der Meer, Graeme; Linkhorn, Hannah; Gruber, Maayan; Mahadevan, Murali; Barber, Colin

    2017-03-01

    Extraskeletal Ewing's sarcoma is a rare tumor, and the management of airway compromise in case of cervical Ewing's sarcoma has not been established. This report describes the case of a patient with retrotracheal Ewing's sarcoma and discusses a successful approach to airway management. A 12-year-old male presented with a 2-week history of sore throat and sleep-disordered breathing and 48 hours of stridor. Imaging confirmed a retrotracheal soft tissue mass with airway compromise. A planned and controlled approach to his airway management resulted in a secure airway prior to definitive treatment.

  19. Integrating sustainable development into the Fourth Assessment Report of the Intergovernmental Panel on Climate Change

    International Nuclear Information System (INIS)

    Najam, Adil; Rahman, Atiq A.; Huq, Saleemul; Sokona, Youba

    2003-01-01

    This paper reviews how sustainable development was treated in prior assessment reports of the Intergovernmental Panel on Climate Change (IPCC) and presents proposals on how it might be integrated into the forthcoming Fourth Assessment Report (AR4). There has been a steady, but slow, increase in the exposure and treatment of sustainable development in each subsequent IPCC assessment. However, much more remains to be done if the mandate provided in the United Nations Framework Convention on Climate Change (UNFCCC) is to be met. The paper argues that the AR4 can take three practical steps in making the integration more complete. First, at the conceptual level, equity concerns should be made a more pervasive, even central, focus of the AR4. Second, at the analytical level, the examination of alternative development pathways begun during the TAR process needs to be continued and expanded. Third, at the operational level, the AR4 should deal with sustainable development in all its chapters rather than relegating it to a peripheral few, should broaden the base of expertise reflected in its panels of authors and reviewers, and should commission a companion special report on climate change and sustainable development

  20. Generic safety evaluation report regarding integrity of BWR scram system piping

    International Nuclear Information System (INIS)

    1981-08-01

    Safety concerns associated with postulated pipe breaks in the boiling water reactor (BWR) scram system were identified during the staff's continuing investigation of the Browns Ferry Unit 3 control rod partial insertion failure on June 28, 1980. This report includes an evaluation of the licensing basis for the BWR scram discharge volume (SDV) piping and an assessment of the potential for the SDV piping to fail while in service. A discussion of the means available for mitigation an unlikely SDV system failure is provided. Generic recommendations are made to improve mitigation capability and ensure that system integrity is maintained in service

  1. Autophagy Deficiency Compromises Alternative Pathways of Respiration following Energy Deprivation in Arabidopsis thaliana.

    Science.gov (United States)

    Barros, Jessica A S; Cavalcanti, João Henrique F; Medeiros, David B; Nunes-Nesi, Adriano; Avin-Wittenberg, Tamar; Fernie, Alisdair R; Araújo, Wagner L

    2017-09-01

    Under heterotrophic conditions, carbohydrate oxidation inside the mitochondrion is the primary energy source for cellular metabolism. However, during energy-limited conditions, alternative substrates are required to support respiration. Amino acid oxidation in plant cells plays a key role in this by generating electrons that can be transferred to the mitochondrial electron transport chain via the electron transfer flavoprotein/ubiquinone oxidoreductase system. Autophagy, a catabolic mechanism for macromolecule and protein recycling, allows the maintenance of amino acid pools and nutrient remobilization. Although the association between autophagy and alternative respiratory substrates has been suggested, the extent to which autophagy and primary metabolism interact to support plant respiration remains unclear. To investigate the metabolic importance of autophagy during development and under extended darkness, Arabidopsis ( Arabidopsis thaliana ) mutants with disruption of autophagy ( atg mutants) were used. Under normal growth conditions, atg mutants showed lower growth and seed production with no impact on photosynthesis. Following extended darkness, atg mutants were characterized by signatures of early senescence, including decreased chlorophyll content and maximum photochemical efficiency of photosystem II coupled with increases in dark respiration. Transcript levels of genes involved in alternative pathways of respiration and amino acid catabolism were up-regulated in atg mutants. The metabolite profiles of dark-treated leaves revealed an extensive metabolic reprogramming in which increases in amino acid levels were partially compromised in atg mutants. Although an enhanced respiration in atg mutants was observed during extended darkness, autophagy deficiency compromises protein degradation and the generation of amino acids used as alternative substrates to the respiration. © 2017 American Society of Plant Biologists. All Rights Reserved.

  2. A Study on Integrated Control Network for Multiple Automation Services-1st year report

    Energy Technology Data Exchange (ETDEWEB)

    Hyun, D.H.; Park, B.S.; Kim, M.S.; Lim, Y.H.; Ahn, S.K. [Korea Electric Power Research Institute, Taejon (Korea)

    2002-07-01

    This report describes the development of Integrated and Intelligent Gateway which is under developed. The network operating technique in this report can identifies the causes of the communication faults and can avoid communication network faults in advance. Utility companies spend large financial investment and time for supplying the stabilized power. Since this is deeply related to the reliability of Automation Systems, it is natural to employ Fault-Tolerant communication network for Automation Systems. Use of the network system developed in this report is not limited in DAS. It can be expandable to the many kinds of data services for customer. Thus this report suggests the direction of the communication network development. This 1st year report is composed of following contents, 1) The introduction and problems of DAS. 2) The configuration and functions of IIG. 3) The protocols. (author). 27 refs., 73 figs., 6 tabs.

  3. Integrated Nuclear-Renewable Energy Systems: Foundational Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    Bragg-Sitton, Shannon [Idaho National Lab. (INL), Idaho Falls, ID (United States); Boardman, Richard [Idaho National Lab. (INL), Idaho Falls, ID (United States); Ruth, Mark [National Renewable Energy Lab. (NREL), Golden, CO (United States); Zinaman, Owen [National Renewable Energy Lab. (NREL), Golden, CO (United States); Forsberg, Charles [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Collins, John [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-08-01

    The U.S. Department of Energy (DOE) recognizes the need to transform the energy infrastructure of the U.S. and elsewhere to systems that can drastically reduce environmental impacts in an efficient and economically viable manner while utilizing both hydrocarbon resources and clean energy generation sources. Thus, DOE is supporting research and development that could lead to more efficient utilization of clean energy generation sources, including renewable and nuclear options. A concept being advanced by the DOE Offices of Nuclear Energy (NE) and Energy Efficiency and Renewable Energy (EERE) is tighter coupling of nuclear and renewable energy sources in a manner that produces new energy currency for the combined electricity grid, industrial manufacturing, and the transportation energy sectors. This integration concept has been referred to as a “hybrid system” that is capable of providing the right type of energy, at the right time, in the right place. At the direction of DOE-NE and DOE-EERE leadership, project leads at Idaho National Laboratory (INL), National Renewable Energy Laboratory (NREL) and Massachusetts Institute of Technology (MIT) have identified and engaged stakeholders in discussing integrated energy systems that would optimize renewable and nuclear energy integration on a region-by-region basis. Subsequent work will entail conduct of technical, economic, environmental and socio-political evaluations of the leading integrated system options based on a set of criteria established with stakeholder input. The Foundational Workshop for Integrated Nuclear – Renewable Energy Systems was organized around the following objectives: 1. Identify and refine priority region-specific opportunities for integrated nuclear-renewable energy systems in the U.S.; 2. Select Figures of Merit (FOM) to rank and prioritize candidate systems; 3. Discuss enabling technology development needs; 4. Identify analysis requirements, capabilities and gaps to estimate FOM for

  4. Integrated Nuclear-Renewable Energy Systems: Foundational Workshop Report

    International Nuclear Information System (INIS)

    2014-01-01

    The U.S. Department of Energy (DOE) recognizes the need to transform the energy infrastructure of the U.S. and elsewhere to systems that can drastically reduce environmental impacts in an efficient and economically viable manner while utilizing both hydrocarbon resources and clean energy generation sources. Thus, DOE is supporting research and development that could lead to more efficient utilization of clean energy generation sources, including renewable and nuclear options. A concept being advanced by the DOE Offices of Nuclear Energy (NE) and Energy Efficiency and Renewable Energy (EERE) is tighter coupling of nuclear and renewable energy sources in a manner that produces new energy currency for the combined electricity grid, industrial manufacturing, and the transportation energy sectors. This integration concept has been referred to as a ''hybrid system'' that is capable of providing the right type of energy, at the right time, in the right place. At the direction of DOE-NE and DOE-EERE leadership, project leads at Idaho National Laboratory (INL), National Renewable Energy Laboratory (NREL) and Massachusetts Institute of Technology (MIT) have identified and engaged stakeholders in discussing integrated energy systems that would optimize renewable and nuclear energy integration on a region-by-region basis. Subsequent work will entail conduct of technical, economic, environmental and socio-political evaluations of the leading integrated system options based on a set of criteria established with stakeholder input. The Foundational Workshop for Integrated Nuclear - Renewable Energy Systems was organized around the following objectives: 1. Identify and refine priority region-specific opportunities for integrated nuclear-renewable energy systems in the U.S.; 2. Select Figures of Merit (FOM) to rank and prioritize candidate systems; 3. Discuss enabling technology development needs; 4. Identify analysis requirements, capabilities and gaps to

  5. Safety and Efficacy of Alginate Adhesion Barrier Gel in Compromised Intestinal Anastomosis.

    Science.gov (United States)

    Chaturvedi, Ankit A; Yauw, Simon T K; Lomme, Roger M L M; Hendriks, Thijs; van Goor, Harry

    For any anti-adhesive barrier developed for abdominal surgery, the use under conditions in which anastomotic healing is compromised needs to be investigated. The current study evaluates the effect of a new ultrapure alginate gel on early healing of high-risk anastomoses in the ileum and compares this with the gold standard used in clinical practice. In 75 adult male Wistar rats, a 5 mm ileal segment was resected and continuity was restored by construction of an inverted anastomosis. Rats were divided randomly into a control group and groups receiving either alginate gel or a sodium hyaluronate carboxymethylcellulose (HA/CMC) film around the anastomosis (n = 25 each). Carprofen, given in a daily dose of 1.25 mg/kg, was used to compromise anastomotic healing. At day three, animals were killed and scored for signs of anastomotic leakage and the presence of adhesions. The incidence of adhesion formation was 95% in the HA/CMC film group, which was significantly higher than in the controls (64%, p = 0.010) and the alginate gel group (52%, p = 0.004). The adhesion score was nearly 40% lower in the alginate gel group compared with the HA/CMC film group. The incidence of ileal leakage in the HA/CMC film group (92%) was significantly higher than in the controls (68%, p = 0.016). Leakage rate did not differ between the alginate gel and control groups. There was no significant difference between groups in either incision bursting pressure or incision breaking strength. Ultrapure alginate gel does not interfere with repair of ileal anastomoses constructed under conditions in which chances of anastomotic dehiscence are high. The alginate gel performs better than the HA/CMC film.

  6. Report on the Audit of the Procurement of the Combined Arms Training-Integrated Evaluation System

    Science.gov (United States)

    1990-05-23

    This is our final report on the Audit of the Procurement of the Combined Arms Training-Integrated Evaluation System (CATIES). We made the audit from...January through September 1989 in response to a Hotline complaint alleging irregularities in the procurement of CATIES. The audit objectives were to

  7. Phenotypic compromises in a long-distance migrant during the transition from migration to reproduction in the High Arctic

    NARCIS (Netherlands)

    Vezina, Francois; Williams, Tony D.; Piersma, Theunis; Morrison, R. I. Guy; Dawson, Alistair

    1. Seasonal carry-over effects may be important structuring components of avian life-history cycles. However, little is known on physiological transitions between stages and on phenotypic compromises that may be made at such time to improve fitness. 2. We studied postmigratory body remodelling in

  8. Identifying compromised systems through correlation of suspicious traffic from malware behavioral analysis

    Science.gov (United States)

    Camilo, Ana E. F.; Grégio, André; Santos, Rafael D. C.

    2016-05-01

    Malware detection may be accomplished through the analysis of their infection behavior. To do so, dynamic analysis systems run malware samples and extract their operating system activities and network traffic. This traffic may represent malware accessing external systems, either to steal sensitive data from victims or to fetch other malicious artifacts (configuration files, additional modules, commands). In this work, we propose the use of visualization as a tool to identify compromised systems based on correlating malware communications in the form of graphs and finding isomorphisms between them. We produced graphs from over 6 thousand distinct network traffic files captured during malware execution and analyzed the existing relationships among malware samples and IP addresses.

  9. Status report on SHARP coupling framework.

    Energy Technology Data Exchange (ETDEWEB)

    Caceres, A.; Tautges, T. J.; Lottes, J.; Fischer, P.; Rabiti, C.; Smith, M. A.; Siegel, A.; Yang, W. S.; Palmiotti, G.

    2008-05-30

    This report presents the software engineering effort under way at ANL towards a comprehensive integrated computational framework (SHARP) for high fidelity simulations of sodium cooled fast reactors. The primary objective of this framework is to provide accurate and flexible analysis tools to nuclear reactor designers by simulating multiphysics phenomena happening in complex reactor geometries. Ideally, the coupling among different physics modules (such as neutronics, thermal-hydraulics, and structural mechanics) needs to be tight to preserve the accuracy achieved in each module. However, fast reactor cores in steady state mode represent a special case where weak coupling between neutronics and thermal-hydraulics is usually adequate. Our framework design allows for both options. Another requirement for SHARP framework has been to implement various coupling algorithms that are parallel and scalable to large scale since nuclear reactor core simulations are among the most memory and computationally intensive, requiring the use of leadership-class petascale platforms. This report details our progress toward achieving these goals. Specifically, we demonstrate coupling independently developed parallel codes in a manner that does not compromise performance or portability, while minimizing the impact on individual developers. This year, our focus has been on developing a lightweight and loosely coupled framework targeted at UNIC (our neutronics code) and Nek (our thermal hydraulics code). However, the framework design is not limited to just using these two codes.

  10. Challenges of Integrated Water Resources Management in Indonesia

    Directory of Open Access Journals (Sweden)

    Mohamad Ali Fulazzaky

    2014-07-01

    Full Text Available The increased demands for water and land in Indonesia as a consequence of the population growth and economic development has reportedly have been accelerated from the year to year. The spatial and temporal variability of human induced hydrological changes in a river basin could affect quality and quantity of water. The challenge is that integrated water resources management (IWRM should cope with complex issues of water in order to maximize the resultant economic and social welfare in an equitable manner, without compromising the sustainability of vital ecosystems. Even though the government of Indonesia has adopted new paradigm for water resources management by the enactment of Law No. 7/2004 on water resources, the implementation of IWRM may face the technical and managerial challenges. This paper briefly reviews the implementation of IWRM and related principles and provides an overview of potential water-related issues and progress towards implementation of IWRM in Indonesia. The availability of water and a broader range of water-related issues are identified. The recommended actions for improving the future IWRM are suggested. Challenges to improve the capacity buildings of IWRM related to enabling environment, institutional frameworks and management instruments are verified to contribute to the future directions for efficient problem-solving ability.

  11. Protecting Privacy of Shared Epidemiologic Data without Compromising Analysis Potential

    Directory of Open Access Journals (Sweden)

    John Cologne

    2012-01-01

    Full Text Available Objective. Ensuring privacy of research subjects when epidemiologic data are shared with outside collaborators involves masking (modifying the data, but overmasking can compromise utility (analysis potential. Methods of statistical disclosure control for protecting privacy may be impractical for individual researchers involved in small-scale collaborations. Methods. We investigated a simple approach based on measures of disclosure risk and analytical utility that are straightforward for epidemiologic researchers to derive. The method is illustrated using data from the Japanese Atomic-bomb Survivor population. Results. Masking by modest rounding did not adequately enhance security but rounding to remove several digits of relative accuracy effectively reduced the risk of identification without substantially reducing utility. Grouping or adding random noise led to noticeable bias. Conclusions. When sharing epidemiologic data, it is recommended that masking be performed using rounding. Specific treatment should be determined separately in individual situations after consideration of the disclosure risks and analysis needs.

  12. Protecting Privacy of Shared Epidemiologic Data without Compromising Analysis Potential

    International Nuclear Information System (INIS)

    Cologne, J.; Nakashima, E.; Funamoto, S.; Grant, E.J.; Chen, Y.; Hiroaki Katayama, H.

    2012-01-01

    Objective. Ensuring privacy of research subjects when epidemiologic data are shared with outside collaborators involves masking (modifying) the data, but over masking can compromise utility (analysis potential). Methods of statistical disclosure control for protecting privacy may be impractical for individual researchers involved in small-scale collaborations. Methods. We investigated a simple approach based on measures of disclosure risk and analytical utility that are straightforward for epidemiologic researchers to derive. The method is illustrated using data from the Japanese Atomic-bomb Survivor population. Results. Masking by modest rounding did not adequately enhance security but rounding to remove several digits of relative accuracy effectively reduced the risk of identification without substantially reducing utility. Grouping or adding random noise led to noticeable bias. Conclusions. When sharing epidemiologic data, it is recommended that masking be performed using rounding. Specific treatment should be determined separately in individual situations after consideration of the disclosure risks and analysis needs

  13. Phenotypic compromises in a long-distance migrant during the transition from migration to reproduction in the High Arctic

    NARCIS (Netherlands)

    Vézina, F.; Williams, T.D.; Piersma, T.; Morrison, R.I.G.

    2012-01-01

    1. Seasonal carry-over effects may be important structuring components of avian life-history cycles. However, little is known on physiological transitions between stages and on phenotypic compromises that may be made at such time to improve fitness.
    2. We studied postmigratory body remodelling in

  14. An integrated fiber and stone basket device for use in Thulium fiber laser lithotripsy

    Science.gov (United States)

    Wilson, Christopher R.; Hutchens, Thomas C.; Hardy, Luke A.; Irby, Pierce B.; Fried, Nathaniel M.

    2014-03-01

    The Thulium fiber laser (TFL) is being explored as an alternative laser lithotripter to the Holmium:YAG laser. The TFL's superior near-single mode beam profile enables higher power transmission through smaller fibers with reduced proximal fiber tip damage. Recent studies have also reported that attaching hollow steel tubing to the distal fiber tip decreases fiber degradation and burn-back without compromising stone ablation rates. However, significant stone retropulsion was observed, which increased with pulse rate. In this study, the hollow steel tip fiber design was integrated with a stone basket to minimize stone retropulsion during ablation. A device was constructed consisting of a 100-μm-core, 140-μm-OD silica fiber outfitted with 5-mm-long stainless steel tubing at the distal tip, and integrated with a 1.3-Fr (0.433-mm-OD) disposable nitinol wire basket, to form an overall 1.9-Fr (0.633-mm- OD) integrated device. This compact design may provide several potential advantages including increased flexibility, higher saline irrigation rates through the ureteroscope working channel, and reduced fiber tip degradation compared to separate fiber and stone basket manipulation. TFL pulse energy of 31.5 mJ with 500 μs pulse duration and pulse rate of 500 Hz was delivered through the integrated fiber/basket device in contact with human uric acid stones, ex vivo. TFL stone ablation rates measured 1.5 +/- 0.2 mg/s, comparable to 1.7 +/- 0.3 mg/s (P > 0.05) using standard bare fiber tips separately with a stone basket. With further development, this device may be useful for minimizing stone retropulsion, thus enabling more efficient TFL lithotripsy at higher pulse rates.

  15. Identifying and Embedding Common Indicators of Compromise in Virtual Machines for Lab-Based Incident Response Education

    Science.gov (United States)

    2015-09-01

    as an ever more popular method of exploiting hosts. Because the Internet is used for things like ecommerce , trading, voting, government, services...HTTP hypertext transfer protocol IE Internet Explorer IMAP Internet message access protocol IOC indicators of compromise IP Internet protocol MD5...notification of detection. These questions not only deal with how an incident is detected, but with the detection system itself. Things like whether

  16. W-026 acceptance test report system integration equipment (SIE)(submittal {number_sign} 018.6.A)

    Energy Technology Data Exchange (ETDEWEB)

    Watson, T.L.

    1997-01-27

    Acceptance testing of the System Integration Equipment (SIE) at Hanford was performed in two stages. The first was inconclusive, and resulted in a number of findings. These finding. are summarized as part of this report. The second stage of testing addressed these findings, and performed full system testing per the approved test procedure. This report includes summaries of all testing, results and finding.. Although the SIE did not in some cases perform as required for plant operations, it did perform per the system specification. (These discrepancies were noted and are addressed elsewhere.) Following testing, the system was formaLLy accepted. Documentation of this acceptance is incLuded in this report.

  17. Joint Integration Office Independent Review Committee annual report, 1985

    International Nuclear Information System (INIS)

    1986-08-01

    Comprised of seven persons with extensive experience in the issues of nuclear waste, the Independent Review Committee (IRC) provides independent and objective review of Defense Transuranic Waste Program (DTWP) activities managed by the Joint Integration Office (JIO), formerly the Defense Transuranic Waste Lead Organization (TLO). The Committee is ensured a broad, interdisciplinary perspective since its membership includes representatives from the fields of nuclear engineering, nuclear waste transportation, industrial quality control, systems and environmental engineering and state and local government. The scope of IRC activities includes overall review of specific TLO plans, projects and activities, and technical review of particular research and development projects. The Committee makes specific suggestions and recommendations based upon expertise in the field of TRU Waste Management. The IRC operates as a consulting group, under an independent charter providing objective review of program activities. This report summarizes the 12 major topics reviewed by the committee during 1985

  18. Compromised careers: the occupational transition of immigration and resettlement.

    Science.gov (United States)

    Suto, Melinda

    2009-01-01

    Work is a significant occupational transition that occurs with immigration and resettlement. Problems finding work and regaining economic capital are multi-factorial, differentiated by gender and mediated by specific contexts. Surprisingly, past education and work experience are unreliable predictors of successful employment outcomes. Critical theory and ethnographic concepts informed the methodological approach. Data were generated primarily through in-depth interviews, conducted in English, with 14 well-educated women who immigrated to Canada as adults and sought employment in their professions. The thematic findings were analyzed using Bourdieu's [7] concepts of capital, field and habitus. The theme Compromised Careers describes the downward occupational (work) mobility that occurs despite expectations that education, credentials and work experience are transferable to desirable employment. A devaluation of foreign qualifications and no relevant Canadian work experience function with gendered responsibilities, less social support, and time spent in resettlement activities to create negative work trajectories. The role that federal policies and professional organizations play is examined to reveal the tension between individuals' efforts to find employment and institutional barriers that impede these actions. A critical inquiry approach examined the ruling relations to show how power and privilege function in relation to migrants' occupational transitions.

  19. Mixed waste focus area integrated technical baseline report. Phase I, Volume 2: Revision 0

    International Nuclear Information System (INIS)

    1996-01-01

    This document (Volume 2) contains the Appendices A through J for the Mixed Waste Focus Area Integrated Technical Baseline Report Phase I for the Idaho National Engineering Laboratory. Included are: Waste Type Managers' Resumes, detailed information on wastewater, combustible organics, debris, unique waste, and inorganic homogeneous solids and soils, and waste data information. A detailed list of technology deficiencies and site needs identification is also provided

  20. The impact of clinical trial monitoring approaches on data integrity and cost--a review of current literature.

    Science.gov (United States)

    Olsen, Rasmus; Bihlet, Asger Reinstrup; Kalakou, Faidra; Andersen, Jeppe Ragnar

    2016-04-01

    Monitoring is a costly requirement when conducting clinical trials. New regulatory guidance encourages the industry to consider alternative monitoring methods to the traditional 100 % source data verification (SDV) approach. The purpose of this literature review is to provide an overview of publications on different monitoring methods and their impact on subject safety data, data integrity, and monitoring cost. The literature search was performed by keyword searches in MEDLINE and hand search of key journals. All publications were reviewed for details on how a monitoring approach impacted subject safety data, data integrity, or monitoring costs. Twenty-two publications were identified. Three publications showed that SDV has some value for detection of not initially reported adverse events and centralized statistical monitoring (CSM) captures atypical trends. Fourteen publications showed little objective evidence of improved data integrity with traditional monitoring such as 100 % SDV and sponsor queries as compared to reduced SDV, CSM, and remote monitoring. Eight publications proposed a potential for significant cost reductions of monitoring by reducing SDV without compromising the validity of the trial results. One hundred percent SDV is not a rational method of ensuring data integrity and subject safety based on the high cost, and this literature review indicates that reduced SDV is a viable monitoring method. Alternative methods of monitoring such as centralized monitoring utilizing statistical tests are promising alternatives but have limitations as stand-alone tools. Reduced SDV combined with a centralized, risk-based approach may be the ideal solution to reduce monitoring costs while improving essential data quality.

  1. Integrated Advanced Microwave Sounding Unit-A (AMSU-A). Performance Verification Report: Final Comprehensive Performance Test Report, P/N 1331720-2TST, S/N 105/A1

    Science.gov (United States)

    Platt, R.

    1999-01-01

    This is the Performance Verification Report, Final Comprehensive Performance Test (CPT) Report, for the Integrated Advanced Microwave Sounding Unit-A (AMSU-A). This specification establishes the requirements for the CPT and Limited Performance Test (LPT) of the AMSU-1A, referred to here in as the unit. The sequence in which the several phases of this test procedure shall take place is shown.

  2. 2009 Integrated Biorefinery Platform Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, John [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2009-12-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the U.S. Department of Energy Biomass Program‘s Integrated Biorefinery (IBR) platform review meeting, held on February 18–19, 2009, at the Westin National Harbor, National Harbor, Maryland.

  3. Integrated Disease Surveillance and Response Reporting

    African Journals Online (AJOL)

    Post-intervention assessment on the groups was done.We analysed ... statistically significant (χ = 16.31;df= 1;p< 0.0000) in the intervention group. Conclusion: The study ..... staff; Nurses, Midwives, Environmental. Health Officers ... may also be found at other tiers of healthcare delivery. .... Performance of Integrated Disease.

  4. Integrated thermal treatment systems study. Internal review panel report

    International Nuclear Information System (INIS)

    Cudahy, J.; Escarda, T.; Gimpel, R.

    1995-04-01

    The U.S. Department of Energy (DOE) Office of Technology Development (OTD) commissioned two studies to evaluate nineteen thermal treatment technologies for treatment of DOE mixed low-level waste. These studies were called the Integrated Thermal Treatment System (ITTS) Phase I and Phase II. With the help of the DOE Office of Environmental Management (EM) Mixed Waste Focus Group, OTD formed an ITTS Internal Review Panel to review and comment on the ITTS studies. This Panel was composed of scientists and engineers from throughout the DOE complex, the U.S. Environmental Protection Agency, the California EPA, and private experts. The Panel met from November 15-18, 1994 to review the ITTS studies and to make recommendations on the most promising thermal treatment systems for DOE mixed low-level wastes and on research and development necessary to prove the performance of the technologies. This report describes the findings and presents the recommendations of the Panel

  5. Accomplishments and Compromises in Prediction Research for World Records and Best Performances in Track and Field and Swimming

    Science.gov (United States)

    Liu, Yuanlong; Paul, Stanley; Fu, Frank H.

    2012-01-01

    The conductors of this study reviewed prediction research and studied the accomplishments and compromises in predicting world records and best performances in track and field and swimming. The results of the study showed that prediction research only promises to describe the historical trends in track and field and swimming performances, to study…

  6. Promoting integrity of shift report by applying ISBAR principles among nursing students in clinical placement

    Directory of Open Access Journals (Sweden)

    Pang Weng Ian

    2017-01-01

    Full Text Available Shift report is an essential method for nursing staff to carry out health care communication. The most important purpose of the shift report is to ensure the safety of patients and to provide continuous care. Nursing students are inadequate of clinical experience and rational organization during patient care. They may not be able to handle the critically ill patients and pass the messages to the following nursing staff. ISBAR (Identify, Situation, Background, Assessment and Recommendation tool is increasingly being utilized as a format for structured shift report communication. In this study, a scale of ISBAR principles is designed to provide students with self-assessment and teachers with evaluation, in a way to improve nursing students’ self-awareness of shift report. Hopefully, with the use of the scale of ISBAR, nursing students are able to complete shift report in systemic integrity and orderliness during clinical placement.

  7. A Commentary on "Integrated Reporting: A Review of Developments and Their Implications for the Accounting Curriculum"

    Science.gov (United States)

    Correa Ruiz, Carmen

    2013-01-01

    In this commentary, Correa Ruiz notes that from his analysis, Owen (2013) identified the essential elements to be included in a modern professional accounting curriculum, described how Association of Chartered Certified Accountants (ACCA) has embedded "Integrated Reporting" in its curriculum, and discussed future curriculum development,…

  8. Reporting on the ‘ever closer union’: narrative framing in national news medias and resistance to EU integration

    Directory of Open Access Journals (Sweden)

    Andrew Anzur CLEMENT

    2015-06-01

    Full Text Available The implementation of the EU’s integrative policies has resulted in relatively recent resistance to the integration process. Said popular politicization challenges further prospects for integration as it brings layers of identities to clash. A national identity persists within Member States, which views that boundaries should rest on the state level. This conflicts with the supranational identity implied by EU integration as it often necessitates the removal of national barriers. It is argued that this clash becomes activated through the manner in which news is reported in national medias. From this, a model is unpacked, positing the employment of narrative formats that frame events and issues with European aspects in national terms. Thus, media portrays national identity as conflicting legitimately with supranational integration, suggesting resistance to the EU project as the appropriate stance if the clash is to be resolved. Finally, possible application of the model is discussed.

  9. Integrated plant safety assessment. Systematic evaluation program, Big Rock Point Plant (Docket No. 50-155). Final report

    International Nuclear Information System (INIS)

    1984-05-01

    The Systematic Evaluation Program was initiated in February 1977 by the U.S. Nuclear Regulatory Commission to review the designs of older operating nuclear reactor plants to reconfirm and document their safety. The review provides (1) an assessment of how these plants compare with current licensing safety requirements relating to selected issues, (2) a basis for deciding how these differences should be resolved in an integrated plant review, and (3) a documented evaluation of plant safety when the supplement to the Final Integrated Plant Safety Assessment Report has been issued. This report documents the review of the Big Rock Point Plant, which is one of ten plants reviewed under Phase II of this program. This report indicates how 137 topics selected for review under Phase I of the program were addressed. It also addresses a majority of the pending licensing actions for Big Rock Point, which include TMI Action Plan requirements and implementation criteria for resolved generic issues. Equipment and procedural changes have been identified as a result of the review

  10. ACCOUNTING – THE REZULT OF A COMPROMISE BETWEEN EXPECTATIONS AND EXIGENCIES

    Directory of Open Access Journals (Sweden)

    Mihaela TULVINSCHI

    2017-12-01

    Full Text Available Current concerns in the field of accounting are circumscribed to the need to perfect a unanimously accepted accounting language to be included in the application, as uniformly as possible, of the principles and accounting treatments as a basis in making financial statements. This approach is complicated and implies an extraordinary dynamics. The objective of the article is to investigate whether, in the current economic environment, accounting is able to issue an objective message to meet the expectations and exigencies of all users of financial information. Accounting can provide only a single representation of reality, and the information produced by accounting can only be a compromise between the respect for accounting principles and the care for reflecting economic reality. Accounting is an information system that quantifies, processes and transmits financial information about an economic entity. It establishes the link between economic activities and decision-makers.

  11. INEL integrated spent nuclear fuel consolidation task team report

    International Nuclear Information System (INIS)

    Henry, R.N.; Clark, J.H.; Chipman, N.A.

    1994-01-01

    This document describes a draft plan and schedule to consolidate spent nuclear fuel (SNF) and special nuclear material (SNW) from aging storage facilities throughout the Idaho National Engineering Laboratory (INEL) to the Idaho Chemical Processing Plant (ICPP) in a safe, cost-effective, and expedient manner. A fully integrated and resource-loaded schedule was developed to achieve consolidation as soon as possible. All of the INEL SNF and SNM management task, projects, and related activities from fiscal year 1994 to the end of the consolidation period are logic-tied and integrated with each other. The schedule and plan are presented to initiate discussion of their implementation, which is expected to generate alternate concepts that can be evaluated using the methodology described in this report. Three perturbations to consolidating SNF as soon as possible are also explored. If the schedule is executed as proposed, the new and on-going consolidation activities will require about 6 years to complete and about $25.3M of additional funding. Reduced annual operating costs are expected to recover the additional investment in about 6.4 years. The total consolidation program as proposed will cost about $66.8M and require about 6 years to recover via reduced operating costs from retired SNF/SNM storage facilities. Detailed schedules and cost estimates for the Test Reactor Area Materials Test Reactor canal transfers are included as an example of the level of detail that is typical of the entire schedule (see Appendix D). The remaining work packages for each of the INEL SNF consolidation transfers are summarized in this document. Detailed cost and resource information is available upon request for any of the SNF consolidation transfers

  12. Rule-based Information Integration

    NARCIS (Netherlands)

    de Keijzer, Ander; van Keulen, Maurice

    2005-01-01

    In this report, we show the process of information integration. We specifically discuss the language used for integration. We show that integration consists of two phases, the schema mapping phase and the data integration phase. We formally define transformation rules, conversion, evolution and

  13. Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity.

    Science.gov (United States)

    Sojka, Stephen; Amin, Nirav M; Gibbs, Devin; Christine, Kathleen S; Charpentier, Marta S; Conlon, Frank L

    2014-08-01

    The identification and characterization of the cellular and molecular pathways involved in the differentiation and morphogenesis of specific cell types of the developing heart are crucial to understanding the process of cardiac development and the pathology associated with human congenital heart disease. Here, we show that the cardiac transcription factor CASTOR (CASZ1) directly interacts with congenital heart disease 5 protein (CHD5), which is also known as tryptophan-rich basic protein (WRB), a gene located on chromosome 21 in the proposed region responsible for congenital heart disease in individuals with Down's syndrome. We demonstrate that loss of CHD5 in Xenopus leads to compromised myocardial integrity, improper deposition of basement membrane, and a resultant failure of hearts to undergo cell movements associated with cardiac formation. We further report that CHD5 is essential for CASZ1 function and that the CHD5-CASZ1 interaction is necessary for cardiac morphogenesis. Collectively, these results establish a role for CHD5 and CASZ1 in the early stages of vertebrate cardiac development. © 2014. Published by The Company of Biologists Ltd.

  14. Surgical manipulation compromises leukocyte mobilisation responses and inflammation after experimental cerebral ischaemia in mice

    Directory of Open Access Journals (Sweden)

    Adam eDenes

    2014-01-01

    Full Text Available Acute brain injury results in peripheral inflammatory changes, although the impact of these processes on neuronal death and neuroinflammation is currently unclear. To facilitate the translation of experimental studies to clinical benefit, it is vital to characterize the mechanisms by which acute brain injury induces peripheral inflammatory changes, and how these are affected by surgical manipulation in experimental models. Here we show that in mice, even mild surgical manipulation of extracranial tissues induced marked granulocyte mobilisation (300% and systemic induction of cytokines. However, intracranial changes induced by craniotomy, or subsequent induction of focal cerebral ischaemia were required to induce egress of CXCR2-positive granulocytes from the bone marrow. CXCR2 blockade resulted in reduced mobilisation of granulocytes from the bone marrow, caused an unexpected increase in circulating granulocytes, but failed to effect brain injury induced by cerebral ischaemia. We also demonstrate that isoflurane anaesthesia interferes with circulating leukocyte responses, which could contribute to the reported vascular and neuroprotective effects of isoflurane. In addition, no immunosuppression develops in the bone marrow after experimental stroke. Thus, experimental models of cerebral ischaemia are compromised by surgery and anaesthesia in proportion to the severity of surgical stress and overall tissue injury. Understanding the inherent confounding effects of surgical manipulation and development of new models of cerebral ischaemia with minimal surgical intervention could facilitate better understanding of interactions between inflammation and brain injury.

  15. Umami Increases Consumer Acceptability, and Perception of Sensory and Emotional Benefits without Compromising Health Benefit Perception.

    Science.gov (United States)

    Miyaki, Takashi; Retiveau-Krogmann, Annlyse; Byrnes, Erin; Takehana, Shunji

    2016-02-01

    This study was undertaken to understand how consumers in the United States perceive umami-rich products, specifically low sodium chicken noodle soup. Results suggest that the addition of monosodium l-glutamate (MSG) at a concentration of 0.1% to 0.5%, alone or in synergy with 5'-ribonucleotides of inosine monophosphate (IMP) at 0.1% not only increases consumer acceptance but also positively impacts other aspects of consumer perception. Regardless of concentration of MSG and IMP, samples enhanced in umami compounds were perceived as more savory, flavorful, and less bland while providing a more homemade, fresh, and healthy wholesome taste than a control sample. From a functional and emotional benefit standpoint, when consuming umami-rich samples, consumers reported feeling significantly higher general satisfaction (they felt more content, relaxed, satisfied, less disappointed, dissatisfied…) and heightened positive emotions (happy, excited, indulgent…) than under the control condition. The feeling of being healthy while consuming the dish was not compromised. Last, when asked how they would feel if serving the soup sample to their family or friends, consumers projected feeling more positively under the umami-rich conditions (more happy, competent, loving, less dissatisfied or disappointed) compared to the control condition. © 2015 Institute of Food Technologists®

  16. Final Report: RPP-WTP Semi-Integrated Pilot Plant

    International Nuclear Information System (INIS)

    Duignan, M. R.; Adamson, D. J.; Calloway, T. B.; Fowley, M. D.; Qureshi, Z. H.; Steimke, J. L.; Williams, M. R.; Zamecnik, J. R.

    2005-01-01

    In August 2004 the last of the SIPP task testing ended--a task that formally began with the issuance of the RPP-WTP Test Specification in June 2003. The planning for the task was a major effort in itself and culminated with the input of all stakeholders, DOE, Bechtel National, Inc., Washington Group International, in October 2003 at Hanford, WA (Appendix A). This report documents the activities carried out as a result of that planning. Campaign IV, the fourth and final step towards the Semi-Integrated Pilot Plant (SIPP) task, conducted by the Savannah River National Laboratory (SRNL) at the Savannah River Site, was to take the several recycle streams produced in Campaign III, the third step of the task, and combine them with other simulated recycle and chosen waste streams. (Campaign III was fed recycles from Campaign II, as Campaign II was fed by Campaign I.) The combined stream was processed in a fashion that mimicked the pretreatment operations of the DOE River Protection Project--Waste Treatment and Immobilization Plant (RPP-WTP) with the exception of the Ion Exchange Process. The SIPP task is considered semi-integrated because it only deals with the pretreatment operations of the RPP-WTP. That is, the pilot plant starts by receiving waste from the tank farm and ends when waste is processed to the point of being sent for vitrification. The resulting pretreated LAW and HLW simulants produced by the SIPP were shipped to VSL (Vitreous State Laboratory) and successfully vitrified in pilot WTP melters. Within the SIPP task these steps are referred to as Campaigns and there were four Campaigns in all. Campaign I, which is completely different than other campaigns, subjected a simulant of Hanford Tank 241-AY-102/C-106 (AY102) waste to cross-flow ultrafiltration only and in that process several important recycle streams were produced as a result of washing the simulant and cleaning the cross-flow filter. These streams were fed to subsequent campaigns and that work was

  17. Final Report: RPP-WTP Semi-Integrated Pilot Plant

    Energy Technology Data Exchange (ETDEWEB)

    Duignan, M. R.; Adamson, D. J.; Calloway, T. B.; Fowley, M. D.; Qureshi, Z. H.; Steimke, J. L.; Williams, M. R.; Zamecnik, J. R.

    2005-06-01

    In August 2004 the last of the SIPP task testing ended--a task that formally began with the issuance of the RPP-WTP Test Specification in June 2003. The planning for the task was a major effort in itself and culminated with the input of all stakeholders, DOE, Bechtel National, Inc., Washington Group International, in October 2003 at Hanford, WA (Appendix A). This report documents the activities carried out as a result of that planning. Campaign IV, the fourth and final step towards the Semi-Integrated Pilot Plant (SIPP) task, conducted by the Savannah River National Laboratory (SRNL) at the Savannah River Site, was to take the several recycle streams produced in Campaign III, the third step of the task, and combine them with other simulated recycle and chosen waste streams. (Campaign III was fed recycles from Campaign II, as Campaign II was fed by Campaign I.) The combined stream was processed in a fashion that mimicked the pretreatment operations of the DOE River Protection Project--Waste Treatment and Immobilization Plant (RPP-WTP) with the exception of the Ion Exchange Process. The SIPP task is considered semi-integrated because it only deals with the pretreatment operations of the RPP-WTP. That is, the pilot plant starts by receiving waste from the tank farm and ends when waste is processed to the point of being sent for vitrification. The resulting pretreated LAW and HLW simulants produced by the SIPP were shipped to VSL (Vitreous State Laboratory) and successfully vitrified in pilot WTP melters. Within the SIPP task these steps are referred to as Campaigns and there were four Campaigns in all. Campaign I, which is completely different than other campaigns, subjected a simulant of Hanford Tank 241-AY-102/C-106 (AY102) waste to cross-flow ultrafiltration only and in that process several important recycle streams were produced as a result of washing the simulant and cleaning the cross-flow filter. These streams were fed to subsequent campaigns and that work was

  18. Macronutrient manipulations of cheese resulted in lower energy content without compromising its satiating capacity

    DEFF Research Database (Denmark)

    Hansen, Thea Toft; Sjödin, Anders Mikael; Ritz, Christian

    2018-01-01

    Manipulation of food’s macronutrient composition in order to reduce energy content without compromising satiating capacity may be helpful in body weight control. For cheeses, substituting fat with protein may provide such opportunity. We aimed at examining the acute effect of cheeses with different...... macronutrient compositions on accumulated energy intake and subjective appetite sensation. A total of thirty-nine normal-weight (average BMI 24·4 kg/m2) men and women completed the partly double-blind, randomised crossover study with high-protein/low-fat (HP/LF, 696 kJ), high-protein/high-fat (HP/HF, 976 k...

  19. UAS-NAS Integrated Human in the Loop: Test Environment Report

    Science.gov (United States)

    Murphy, Jim; Otto, Neil; Jovic, Srba

    2015-01-01

    The desire and ability to fly Unmanned Aircraft Systems (UAS) in the National Airspace System (NAS) is of increasing urgency. The application of unmanned aircraft to perform national security, defense, scientific, and emergency management are driving the critical need for less restrictive access by UAS to the NAS. UAS represent a new capability that will provide a variety of services in the government (public) and commercial (civil) aviation sectors. The growth of this potential industry has not yet been realized due to the lack of a common understanding of what is required to safely operate UAS in the NAS. NASA's UAS Integration in the NAS Project is conducting research in the areas of Separation Assurance/Sense and Avoid Interoperability (SSI), Human Systems Integration (HSI), and Communication to support reducing the barriers of UAS access to the NAS. This research was broken into two research themes namely, UAS Integration and Test Infrastructure. UAS Integration focuses on airspace integration procedures and performance standards to enable UAS integration in the air transportation system, covering Sense and Avoid (SAA) performance standards, command and control performance standards, and human systems integration. The focus of the Test Infrastructure theme was to enable development and validation of airspace integration procedures and performance standards, including the execution of integrated test and evaluation. In support of the integrated test and evaluation efforts, the Project developed an adaptable, scalable, and schedulable relevant test environment incorporating live, virtual, and constructive elements capable of validating concepts and technologies for unmanned aircraft systems to safely operate in the NAS. To accomplish this task, the Project planned to conduct three integrated events: a Human-in-the-Loop simulation and two Flight Test series that integrated key concepts, technologies and/or procedures in a relevant air traffic environment. Each of

  20. CT-morphological characterization of respiratory syncytial virus (RSV) pneumonia in immune-compromised adults

    International Nuclear Information System (INIS)

    Mayer, J.L.; Kauczor, H.U.; Lehners, N.; Egerer, G.; Heussel, C.P.

    2014-01-01

    Characterization and follow-up evaluation of chest CT of RSV pneumonia in immune-compromised adults during a seasonal epidemic. Retrospective analysis of 132 chest CT examinations of 51 adult immune-compromised patients (29 m/22f, diameter 58 years) with clinical signs of pneumonia and positive RSV test in winter 2011/2012. Two experienced chest radiologists evaluated the morphology (bronchial wall thickening, tree-in-bud, nodules, halo, ground-glass opacities, consolidations, pleural fluid) of the CT scans by consensus. Pathological findings were in 86 % of the chest CT scans: Areas of ground-glass attenuation in 64 %, consolidations in 56 %, nodules in 55 % (diameter 8 mm in maximal diameter, with halo in 71 %), pleural fluid in 44 % (diameter 2 cm), tree-in-bud in 36 %, bronchial wall thickening in 27 % and more than one morphological finding in 72 %. There were no pathological CT findings in 14 % of patients with clinical symptoms of pneumonia because these patients did not undergo follow-up. Radiological progression was found in 45 % of patients and regression in 33 % in follow-up examinations. In 37 % an additional examination of the paranasal sinuses was performed and showed sinusitis in 63 % of cases. 90 % of the patients had sinusitis as well as pneumonia. In addition to RSV, a further pathogenic agent was found in bronchoalveolar lavage of five patients (Aspergillus spec., herpes simplex virus, Pseudomonas aeruginosa). The most characteristic signs in chest CT scans were at the beginning of pneumonia with nodules and tree-in-bud often combined with bronchial wall thickening. The following CT scans showed characteristic but not pathognomonic chest CT findings of RSV pneumonia. These morphological findings should be recognized seasonally (winter) especially at the beginning of the case of pneumonia. RSV-associated additional sinusitis is probably common and should be noticed.

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