WorldWideScience

Sample records for reported clear recollections

  1. Training Recollection in Healthy Older Adults: Clear Improvements on the Training Task, but Little Evidence of Transfer

    Directory of Open Access Journals (Sweden)

    Vess eStamenova

    2014-11-01

    Full Text Available Normal aging holds negative consequences for memory, in particular for the ability to recollect the precise details of an experience. With this in mind, Jennings and Jacoby (2003 developed a recollection training method using a single-probe recognition memory paradigm in which new items (i.e., foils were repeated during the test phase at increasingly long intervals. In previous reports, this method has appeared to improve older adults’ performance on several non-trained cognitive tasks. We aimed to further examine potential transfer effects of this training paradigm and to determine which cognitive functions might predict training gains. Fifty-one older adults were assigned to either recollection training (n = 30 or an active control condition (n = 21 for six sessions over two weeks. Afterward, the recollection training group showed a greatly enhanced ability to reject the repeated foils. Surprisingly, however, the training and the control groups improved to the same degree as one another in recognition accuracy (d’ on their respective training tasks. Further, despite the recollection group’s significant improvement in rejecting the repeated foils, we observed little evidence of transfer to non-trained tasks (including a temporal source memory test. Age and higher baseline scores on a measure of global cognitive function (as measured by the Montreal Cognitive Assessment tool and working memory (as measured by Digit Span Backward predicted gains made by the recollection training group members.

  2. Doyon report clears Quebec NUGs

    Energy Technology Data Exchange (ETDEWEB)

    McArthur, D.; Salaff, S.

    1997-06-01

    In mid-1995 the Parti Quebecois, then in opposition, claimed evidence of influence peddling, international drug money laundering, kickbacks and fraud in Quebec`s independent power program. It also claimed evidence of irregularities at Hydro-Quebec in its procedures for approving hydropower projects. The Liberal Quebec government of the day ordered a public inquiry, led by Quebec superior court judge Francois Doyon. He submitted the Commission`s final report in April 1997. The report exonerated Hydro-Quebec and the province`s independent power industry of any criminal wrong doing regarding their respect for legal and regulatory directives and the `ethical norms and practices` of sound business management. In its 600-plus page report, the Doyon Commission found that while there was a certain lack of administrative rigor which allowed certain Hydro-Quebec executives to put themselves in questionable conflict-of-interest situations, their actions were not illegal. The current Parti Quebecois Government accepted the report and its recommendation concerning tightening conflict-of-interest guidelines. The current Liberal opposition in the National Assembly charged that the conclusions of the Commission were a foregone conclusion since the demand for the inquiry was politically motivated right from the beginning.

  3. Pediatric spinal clear cell meningioma. Case report.

    Science.gov (United States)

    Colen, Chaim B; Rayes, Mahmoud; McClendon, Jamal; Rabah, Raja; Ham, Steven D

    2009-01-01

    In this report the authors describe a unique case of spinal clear cell meningioma in a 13-year-old girl. Clear cell meningiomas (CCMs) are not uncommon. To the authors' knowledge, 14 cases of pediatric CCM occurring in the spinal canal have been reported. Factors lending resistance to meningioma initiation and invasion are analyzed. This 13-year-old girl presented with pain radiating down her left leg. Admission MR imaging showed an inhomogeneous enhancing intradural-extramedullary mass at the L4-5 level. Resection revealed a CCM, and radiotherapy was subsequently administered. Postoperatively there has been no recurrence in > 2 years. In this paper the authors report a case of CCM and provide a comprehensive literature review on this disease. Current recommendations for its management are still debatable, especially in the pediatric population, and the authors propose an algorithm for its treatment and surveillance.

  4. Advanced ThioClear process testing. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lani, B.

    1998-03-01

    Wet scrubbing is the leading proven commercial post-combustion FGD technology available to meet the sulfur dioxide reductions required by the Clean Air Act Amendments. To reduce costs associated with wet FGD, Dravo Lime Company has developed the ThioClear process. ThioClear is an ex-situ forced oxidation magnesium-enhanced lime FGD process. ThioClear process differs from the conventional magnesium-enhanced lime process in that the recycle liquor has minimal suspended solids and the by-products are wallboard quality gypsum and magnesium hydroxide, an excellent reagent for water treatment. The process has demonstrated sulfur dioxide removal efficiencies of +95% in both a vertical spray scrubber tower and a horizontal absorber operating at gas velocities of 16 fps, respectively. This report details the optimization studies and associated economics from testing conducted at Dravo Lime Company`s pilot plant located at the Miami Fort Station of the Cincinnati Gas and Electric Company.

  5. ClearFuels-Rentech Integrated Biorefinery Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Pearson, Joshua [Project Director

    2014-02-26

    The project Final Report describes the validation of the performance of the integration of two technologies that were proven individually on a pilot scale and were demonstrated as a pilot scale integrated biorefinery. The integrated technologies were a larger scale ClearFuels’ (CF) advanced flexible biomass to syngas thermochemical high efficiency hydrothermal reformer (HEHTR) technology with Rentech’s (RTK) existing synthetic gas to liquids (GTL) technology.

  6. Clear cell sarcoma of the kidney: A case report

    Directory of Open Access Journals (Sweden)

    Dipanwita Nag

    2014-01-01

    Full Text Available Clear cell sarcoma of the kidney is a rare malignant neoplasm of childhood, known for its aggressiveness, its tendency for recurrence, and to metastasize to bone. We report the observation of 8-month-old child presenting with a large abdominal mass. Clinically, it was diagnosed as Wilm′s tumor, and left nephrectomy was done. Grossly, 10 cm × 8 cm × 3.5 cm globular, white, encapsulated, smooth mass uniformly involving the whole kidney was noted. Histologically, the tumor was diagnosed as clear cell sarcoma with renal vein showing presence of tumor embolus in lumen. The tumor was given stage-II (NWTS-5 protocol. Immunohistochemistry showed vimentin positive and cytokeratin negative tumor cells. The child is currently undergoing chemotherapy and has not yet shown any sign of bony metastasis.

  7. Mere Recollection of Food Reduces Altruistic Behavior

    Directory of Open Access Journals (Sweden)

    Okamura Yasuto

    2017-06-01

    Full Text Available The purpose of the study was twofold: Experiment 1 tested the possibility that the mere recollection of food aroused a state of hunger and that different types of food influenced the state of hunger differently; Experiment 2 tested the possibility that food cues affected altruistic behavior. In Experiment 1, 28 participants reported how hungry they felt before and after their recollection of certain foods (noodles and pudding. Results suggest that recollection of food increased hunger and that the type of food influenced the degree of hunger (F(2,54 = 31.88, p < .001, η2 = .54. In Experiment 2, 63 participants were randomly assigned to one of three recollection conditions: (1 noodles, (2 pudding, and (3 control. Participants in the two conditions described each food in detail; control group participants did not. Participants were then asked how much they would be willing to participate in an ostensible experiment. Results indicate that recollection-induced hunger reduced altruistic behavior (F(2, 60 = 4.11, p = .021, η2 = .12. Cue reactivity theory and the hierarchy of needs could explain these results.

  8. Anterior Crossbite and Crowding Correction with a Series of Clear Aligners Involving Lower Incisor Extraction: "The Clear Way" Case Report.

    Science.gov (United States)

    Bawaskar, Naval Suresh

    2015-01-01

    The Clear Aligner can be used to correct tooth movement without involving extraction, surgery, and other adjunct orthopaedic appliances. Some forms ofattachments are required with clear aligners to achieve all major types of orthodontic tooth movements. The Clear Aligner is a procedure that can be performed by a clinician with computer simulation/calculation. Since the Clear Aligner can be fabricated in steps, it is readily available to change the treatment sequence throughout the course of the treatment in cases of complex malocclusions. The patient can receive any necessary dental procedures with ease during the course of the treatment. The treatment can also be easily resumed even if the patient has not worn the aligners for a period of time. The purpose of this article is to report dental anterior crossbite correction with a series of Clear Aligners without the use of any forms of attachments. The Clear Aligner could be used as an alternative in appropriate cases for those who are reluctant with conventional appliances.

  9. Incidental context information increases recollection

    Science.gov (United States)

    Norman, Liam J.; Eacott, Madeline J.; Easton, Alexander

    2017-01-01

    The current study describes a receiver-operating characteristic (ROC) task for human participants based on the spontaneous recognition memory paradigms typically used with rodents. Recollection was significantly higher when an object was in the same location and background as at encoding, a combination used to assess episodic-like memory in animals, but not when only one of these task-irrelevant cues was present. The results show that incidentally encoded cue information can determine the degree of recollection, and opens up the possibility of assessing recollection across species in a single experimental paradigm, allowing better understanding of the cognitive and biological mechanisms at play. PMID:28202718

  10. Could masked conceptual primes increase recollection? The subtleties of measuring recollection and familiarity in recognition memory.

    Science.gov (United States)

    Taylor, Jason R; Henson, Richard N

    2012-11-01

    We begin with a theoretical overview of the concepts of recollection and familiarity, focusing, in the spirit of this special issue, on the important contributions made by Andrew Mayes. In particular, we discuss the issue of when the generation of semantically-related information in response to a retrieval cue might be experienced as recollection rather than familiarity. We then report a series of experiments in which two different types of masked prime, presented immediately prior to the test cue in a recognition memory paradigm, produced opposite effects on Remember vs. Know judgments. More specifically, primes that were conceptually related to the test item increased the incidence of Remember judgments, though only when intermixed with repetition primes (which increased the incidence of Know judgments instead, as in prior studies). One possible explanation--that the fluency of retrieval of item-context associations can be experienced as recollection, even when the source of that fluency is unknown--is counter to conventional views of recollection and familiarity, though it was anticipated by Andrew in his writings nearly two decades ago.

  11. Clear cell variant of intraosseous mucoepidermoid carcinoma: Report of a rare entity

    Directory of Open Access Journals (Sweden)

    Sujatha Varma

    2012-01-01

    Full Text Available Intraosseous mucoepidermoid carcinoma of jaw bones is a rare lesion. Abundance of clear cells in an intraosseous mucoepidermoid carcinoma may complicate its histopathologic diagnosis. It becomes extremely important to distinguish this lesion from other clear cell lesions of jaw region. Here, we report a case of clear cell variant of intraosseous mucoepidermoid carcinoma in the mandible.

  12. Clear cell variant of calcifying epithelial odontogenic tumor of maxilla: Report of a rare case.

    Science.gov (United States)

    Badrashetty, Dinesh; Rangaswamy, Shruthi; Belgode, Niranjan

    2013-09-01

    The calcifying epithelial odontogenic tumor (CEOT) is a rare benign tumor of the jaws. Pindborg's tumor having clear cells is extremely rare. Twelve central lesions have been reported of which only three cases have occurred in maxilla. Clear cell variant is a distinct entity, has more aggressive biological behavior and higher chances of recurrence. Hence it is important that presence of clear cells be included in histopathological diagnosis. Here we present a rare case of clear cell CEOT having aggressive behavior.

  13. Clear cell adenocarcinoma of the colon: A case report and review of literature

    Institute of Scientific and Technical Information of China (English)

    Koichi Soga; Ken-Ichi Mukaisho; Takanori Hattori; Hideyuki Konishi; Natsuko Tatsumi; Chika Konishi; Keimei Nakano; Naold Wakabayashi; Shoji Mitsufuji; Keisho Kataoka; Takeshi Okanoue

    2008-01-01

    A primary clear cell adenocarcinoma of the colon is arare oncologic entity.We herein report a case of such atumor of the sigmoid colon in a 71-year-old woman whowas successfully treated by an endoscopic polypecLomy in our hospital.We also reviewed the published reports regarding cases of primary clear cell tumors in the colon.

  14. Clear Lake National Wildlife Refuge : Klamath Basin National Wildlife Refuges : Annual Narrative Report : Calendar Year 1981

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Clear Lake National Wildlife Refuge outlines Refuge accomplishments during the 1981 calendar year. The report begins with a summary...

  15. Narrative report: Clear Lake National Wildlife Refuge, California: August, September, October, 1940

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Clear Lake National Wildlife Refuge outlines Refuge accomplishments from August through October of 1940. The report begins by summarizing...

  16. Recollection reduces unitised familiarity effect.

    Science.gov (United States)

    Shao, Hanyu; Opitz, Bertram; Yang, Jiongjiong; Weng, Xuchu

    2016-01-01

    Two types of encoding tasks have been employed in previous research to investigate the beneficial effect of unitisation on familiarity-based associative recognition (unitised familiarity effect), namely the compound task and the interactive imagery task. Here we show how these two tasks could differentially engage subsequent recollection-based associative recognition and consequently lead to the turn-on or turn-off of the unitised familiarity effect. In the compound task, participants studied unrelated word pairs as newly learned compounds. In the interactive imagery task, participants studied the same word pairs as interactive images. An associative recognition task was used in combination with the Remember/Know procedure to measure recollection-based and familiarity-based associative recognition. The results showed that the unitised familiarity effect was present in the compound task but was absent in the interactive imagery task. A comparison of the compound and the interactive imagery task revealed a dramatic increase in recollection-based associative recognition for the interactive imagery task. These results suggest that unitisation could benefit familiarity-based associative recognition; however, this effect will be eliminated when the memory trace formed is easily accessed by strong recollection without the need for a familiarity assessment.

  17. Aristotle on Memory and Recollection

    DEFF Research Database (Denmark)

    Bloch, David Kristian

    Twentieth-century scholarship on Aristotle's De Memoria et Reminiscentia was dominated by the view that Aristotle's theories of memory and recollection are basically very similar to ours. By means of a new critical edition of the Greek text, an essay on Aristotle's own theories and an essay on th...

  18. Incidental Context Information Increases Recollection

    Science.gov (United States)

    Ameen-Ali, Kamar E.; Norman, Liam J.; Eacott, Madeline J.; Easton, Alexander

    2017-01-01

    The current study describes a receiver-operating characteristic (ROC) task for human participants based on the spontaneous recognition memory paradigms typically used with rodents. Recollection was significantly higher when an object was in the same location and background as at encoding, a combination used to assess episodic-like memory in…

  19. ROC in animals: uncovering the neural substrates of recollection and familiarity in episodic recognition memory.

    Science.gov (United States)

    Sauvage, Magdalena M

    2010-09-01

    It is a consensus that familiarity and recollection contribute to episodic recognition memory. However, it remains controversial whether familiarity and recollection are qualitatively distinct processes supported by different brain regions, or whether they reflect different strengths of the same process and share the same support. In this review, I discuss how adapting standard human recognition memory paradigms to rats, performing circumscribed brain lesions and using receiver operating characteristic (ROC) methods contributed to solve this controversy. First, I describe the validation of the animal ROC paradigms and report evidence that familiarity and recollection are distinct processes in intact rats. Second, I report results from rats with hippocampal dysfunction which confirm this finding and lead to the conclusion that the hippocampus supports recollection but not familiarity. Finally, I describe a recent study focusing on the medial entorhinal cortex (MEC) that investigates the contribution of areas upstream of the hippocampus to recollection and familiarity.

  20. Clear cell variant of calcifying epithelial odontogenic tumor of maxilla: Report of a rare case

    Directory of Open Access Journals (Sweden)

    Dinesh Badrashetty

    2013-01-01

    Full Text Available The calcifying epithelial odontogenic tumor (CEOT is a rare benign tumor of the jaws. Pindborg′s tumor having clear cells is extremely rare. Twelve central lesions have been reported of which only three cases have occurred in maxilla. Clear cell variant is a distinct entity, has more aggressive biological behavior and higher chances of recurrence. Hence it is important that presence of clear cells be included in histopathological diagnosis. Here we present a rare case of clear cell CEOT having aggressive behavior.

  1. Effects of context on recollection and familiarity experiences are task dependent.

    Science.gov (United States)

    Tousignant, Cody; Bodner, Glen E; Arnold, Michelle M

    2015-05-01

    The influence of test context on reports of recollection and familiarity depends on how these subjective recognition experiences are conceptualized and measured. Bodner and Lindsay (2003) found that critical items elicited more remember judgments but fewer know judgments in a less (vs. more) memorable context. In contrast, Tousignant and Bodner (2012) found that independent ratings of recollection and familiarity were both higher in a less memorable context. We replicated the dissociative pattern with judgments using recollect/familiar labels (Experiment 1), and in a novel R/F/B task that added a "both" option to eliminate the mutual exclusivity between the recollect and familiar options (Experiment 2). Adding a "guess" option eliminated these context effects (Experiment 3), however whether allowing guesses "cleans up" or "desensitizes" recollection and familiarity judgments remains unclear. Determining which task variants provide appropriate measures of subjective recognition experiences will require an examination of additional dissociations and triangulation with other measures.

  2. Clear cell adenocarcinoma of a female urethra: A case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Amel Trabelsi

    2009-01-01

    Full Text Available Context : Clear cell adenocarcinoma of the urethra is an extremely rare tumour. Its histogenetic derivation remains controversial. Case report : We report a new case of clear cell adenocarcinoma of the proximal urethra in a 56-year-old woman who presented with grossly hematuria. Urethral cystoscopy revealed a tumour protruding from the posterior urethral wall at the bladder neck. Treatment consisted of urethrocystectomy with pelvic lymph node dissection. Histologically, the neoplasm consisted of clear cell adenocarcinoma of the urethra. Conclusion : It appears that female urethral adenocarcinoma has more than one tissue of origin.

  3. Earliest Recollections and Birth Order: Two Adlerian Exercises.

    Science.gov (United States)

    Parrott, Les

    1992-01-01

    Presents two exercises designed to demonstrate the influence of two Adlerian principles on personality. Includes exercises dealing with birth order and earliest recollection. Concludes that the exercises actively demonstrate major concepts for counseling courses in Adlerian psychotherapy. Reports that students rated both exercises highly, with…

  4. Clear cell odontogenic carcinoma: case report with immunohistochemical findings adding support to the challenging diagnosis

    OpenAIRE

    XAVIER, FLÁVIA CALÓ AQUINO; Rodini, Camila Oliveira; Ramalho,Luciana Maria Pedreira; Sarmento,Viviane Almeida; Nunes, Fabio Daumas

    2008-01-01

    Acesso restrito: Texto completo. p. 403-410 Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor associated with aggressive clinical behavior, metastasis, and low survival. We report a case of CCOC affecting the mandible of a 39-year-old man. The tumor presented a biphasic pattern composed of clear cell nests intermingled with eosinophilic cells and separated by collagenous stroma. Immunoreactivity to cytokeratin (CK), specifically AE1/AE3 and CK 8, 14, 18, and 19 was fou...

  5. Disordered memory awareness: recollective confabulation in two cases of persistent déjà vecu.

    Science.gov (United States)

    Moulin, Christopher J A; Conway, Martin A; Thompson, Rebecca G; James, Niamh; Jones, Roy W

    2005-01-01

    We describe two cases of false recognition in patients with dementia and diffuse temporal lobe pathology who report their memory difficulty as being one of persistent déjà vecu--the sensation that they have lived through the present moment before. On a number of recognition tasks, the patients were found to have high levels of false positives. They also made a large number of guess responses but otherwise appeared metacognitively intact. Informal reports suggested that the episodes of déjà vecu were characterised by sensations similar to those present when the past is recollectively experienced in normal remembering. Two further experiments found that both patients had high levels of recollective experience for items they falsely recognized. Most strikingly, they were likely to recollectively experience incorrectly recognised low frequency words, suggesting that their false recognition was not driven by familiarity processes or vague sensations of having encountered events and stimuli before. Importantly, both patients made reasonable justifications for their false recognitions both in the experiments and in their everyday lives and these we term 'recollective confabulation'. Thus, the patients are characterised by false recognition, overextended recollective experience, and recollective confabulation. These features are accounted for in terms of disrupted control of memory awareness and recollective states, possibly following brain damage to fronto-temporal circuits and we extend this account to normally and abnormally occurring states of déjà vu and vecu and related memory experiences.

  6. Bell's Universe: A Personal Recollection

    CERN Document Server

    Bertlmann, Reinhold A

    2016-01-01

    My collaboration and friendship with John Bell is recollected. I will explain his outstanding contributions in particle physics, in accelerator physics, and his joint work with Mary Bell. Mary's work in accelerator physics is also summarized. I recall our quantum debates, mention some personal reminiscences, and give my personal view on Bell's fundamental work on quantum theory, in particular, on the concept of contextuality and nonlocality of quantum physics. Finally, I describe the huge influence Bell had on my own work, in particular on entanglement and Bell inequalities in particle physics and their experimental verification, and on mathematical physics, where some geometric aspects of the quantum states are illustrated.

  7. Final Report on the Mississippi Project CLEAR Voice Teacher Working Conditions Survey

    Science.gov (United States)

    Berry, Barnett; Fuller, Ed

    2008-01-01

    In 2007, the state of Mississippi conducted a web-based survey of all school-based licensed educators in which they were asked to share their perceptions of the state of teacher working conditions in Mississippi. This report of the Mississippi Teacher Working Conditions Survey, Project CLEAR Voice (Cultivate Learning Environments to Accelerate…

  8. Primary clear cell carcinoma of parotid gland: Case report and review of literature.

    Science.gov (United States)

    Rodríguez, Marta Saldaña; Reija, Maria Fe García; Rodilla, Irene González

    2013-01-01

    Clear cell carcinoma (CCC) is a rare low-grade carcinoma that represents only 1% to 2% of all salivary glands tumors. The finding of a clear cell tumor in a parotid gland involves the necessity of differential diagnosis between primary clear cell parotid tumors and metastases, mainly from kidney. The biological behavior is not very aggressive and development, which is very slow, is usually asymptomatic and indeed, the tumor often reaches considerable dimensions before being diagnosed. The treatment of choice is the surgical excision. There are rare cases of local recurrence and distant metastases. The aim of this article is to report a primary CCC in the parotid gland that microscopically closely resembled a metastatic CCC of renal origin, making microscopic differentiation difficult.

  9. Clear cell adenocarcinoma of the ulterine cervix in a 15 year old girl: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Seung Joon; Kim, Jee Eun; KIm, Hyung Sik; Choi, Hye Young [Dept. of Radiology, Gachon University Gil Hospital, Incheon (Korea, Republic of)

    2013-10-15

    Cervical cancer is rare in the pediatric population. In cases of cervical cancer, adenocarcinoma is predominantly reported. Clear cell adenocarcinoma (CCAC) of the uterine cervix is a very rare tumor and accounts for only 4% of all adenocarcinomas of the uterine cervix. Risk factors and pathogenesis of this disease are not exactly revealed. The intrauterine exposure to diethylstilbestrol (DES) and associated non-steroidal estrogen during pregnancy before 18 weeks is the only known risk factor. This study reports the imaging finding of primary uterine cervical tumor in a 15-year-old girl, who was finally diagnosed with CCAC, with no maternal history of DES exposure in utero.

  10. Primary clear cell ductal adenocarcinoma of the pancreas: A case report and clinicopathologic literature review

    Directory of Open Access Journals (Sweden)

    Yashpal Modi

    2014-01-01

    Full Text Available We present a very rare, interesting case of a carcinoma of the pancreas with predominantly abundant clear cell morphology. According to the WHO classification, primary clear cell carcinoma of the pancreas is classified as a rare "miscellaneous" carcinoma. The tumor was observed in the distal body and tail of the pancreas of a 74-year-old woman. The histopathology of tumor cells showed well-defined cell membranes, clear cytoplasm, and prominent cell boundaries. Immunohistochemical (IHC staining showed positive reactions to antibodies against vimentin, cytokeratin 7 (CK-7, mucicarmine (MUC-1, periodic acid-Schiff (PAS, periodic acid-Schiff with diastase (PASD, carcinoembryonic antigen (CEA, and Carbohydrate Antigen 19-9 (CA 19-9. On the other hand, IHC staining was negative for alpha-fetoprotein (AFP, cytokeratin 20 (CK-20, HMB45, chromogranin, and synaptophysin. The patient was subsequently diagnosed with a primary solid-type pancreatic clear cell carcinoma with hepatic metastasis. Herein, we report this rare case and include a review of the current literature of this tumor.

  11. Clear cell variant of squamous cell carcinoma of skin: A report of a case

    Directory of Open Access Journals (Sweden)

    Ahmed Oluwatoyin Lawal

    2013-01-01

    Full Text Available Clear cell squamous cell carcinoma (SCC is a rare variant of SCC of skin in which ultraviolet radiation has been suggested as possible etiology. This case is that of a 62-year-old male concrete block maker/bricklayer who presented with a 6 months history of a non-healing ulcer on the left side of his face. Histology showed features of malignant epithelial neoplasm composed of islands of large oval to polyhedral malignant squamous cells with eosinophilic to amphophilic cytoplasm and vesicular nuclei and there were areas showing clear cell differentiation and isolated areas of keratin pearl formation. The lesion was also negative for periodic acid schiff, mucicarmine, and alcian blue stains but was strongly positive for AE1/AE3 (immuno-stain. This case showed an aggressive and bizarre clinical presentation but more report of cases are needed to have a better characterization of the clinical presentation and prognosis of this variant of SCC.

  12. Clear cell variant of squamous cell carcinoma of skin: A report of a case.

    Science.gov (United States)

    Lawal, Ahmed Oluwatoyin; Adisa, Akinyele Olumuyiwa; Olajide, Mofoluwaso A; Olusanya, Adeola Adenike

    2013-01-01

    Clear cell squamous cell carcinoma (SCC) is a rare variant of SCC of skin in which ultraviolet radiation has been suggested as possible etiology. This case is that of a 62-year-old male concrete block maker/bricklayer who presented with a 6 months history of a non-healing ulcer on the left side of his face. Histology showed features of malignant epithelial neoplasm composed of islands of large oval to polyhedral malignant squamous cells with eosinophilic to amphophilic cytoplasm and vesicular nuclei and there were areas showing clear cell differentiation and isolated areas of keratin pearl formation. The lesion was also negative for periodic acid schiff, mucicarmine, and alcian blue stains but was strongly positive for AE1/AE3 (immuno-stain). This case showed an aggressive and bizarre clinical presentation but more report of cases are needed to have a better characterization of the clinical presentation and prognosis of this variant of SCC.

  13. Dissociation between the neural correlates of recollection and familiarity in the striatum and hippocampus: Across-study convergence.

    Science.gov (United States)

    King, Danielle R; Chastelaine, Marianne de; Elward, Rachael L; Wang, Tracy H; Rugg, Michael D

    2017-08-10

    In tests of recognition memory, neural activity in the striatum has consistently been reported to differ according to the study status of the test item. A full understanding of the functional significance of striatal 'retrieval success' effects is impeded by a paucity of evidence concerning whether the effects differ according to the nature of the memory signal supporting the recognition judgment (recollection vs. familiarity). Here, we address this issue through an analysis of retrieval-related striatal activity in three independent fMRI studies (total N=88). Recollection and familiarity were operationalized in a different way in each study, allowing the identification of test-independent, generic recollection- and familiarity-related effects. While activity in a bilateral dorsal striatal region, mainly encompassing the caudate nucleus, was enhanced equally by recollected and 'familiar only' test items, activity in bilateral ventral striatum and adjacent subgenual frontal cortex was enhanced only in response to items that elicited successful recollection. By contrast, relative to familiar items, activity in anterior hippocampus was enhanced for both recollected and novel test items. Thus, recollection- and familiarity-driven recognition memory judgments are associated with anatomically distinct patterns of retrieval-related striatal activity, and these patterns are at least partially independent of recollection and novelty effects in the hippocampus. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Recollection and familiarity in the human thalamus.

    Science.gov (United States)

    Carlesimo, Giovanni Augusto; Lombardi, Maria Giovanna; Caltagirone, Carlo; Barban, Francesco

    2015-07-01

    Recollection and familiarity are two distinct forms of recognition memory that differ in terms of the associative richness of the memory experience. In recollection, exposure to a previously encountered item cues the recollection of a number of contextual, temporal and other associative information. In the case of familiarity, instead, the item is recognized as previously encountered, but it does not cue any associative information. According to the dual-process theory, the memory processes that underlie recollection and familiarity are qualitatively different and this distinction is reflected in the existence of different neural substrates underlying the two processes. Thus far, research has primarily focused on distinct regions of the medial temporal lobe as implicated mostly in recollection (hippocampus) or familiarity (perirhinal cortex). Aggleton and Brown (1999) suggested extending the neuroanatomical distinction to other cortical and subcortical areas of the brain, including the thalamus. In particular, they proposed the existence of two reciprocally independent neural circuits for recollection and familiarity. The former would include the hippocampus, the fornix, the mammillary bodies and the anterior thalamic nuclei. The second would involve the mesial magnocellular portion of the mediodorsal nucleus connected to the perirhinal cortex through the ventroamygdalofugal pathway. Here we review neuropsychological evidence in experimental animals and brain-damaged individuals and functional neuroimaging evidence in healthy humans that supports Aggleton and Brown's model at the level of the thalamus. The evidence substantially supports the functional relationship between recollection processes and integrity of the thalamic anterior nuclei. Additional evidence, not predicted by the model, has been provided in favour of the reliance of recollection on the integrity of the lateral portion (parvocellular) of the mediodoral nucleus. Finally, there is sparse and

  15. Skull Base Clear Cell Carcinoma, Metastasis of Renal Primary Tumor: A Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Ilson Sepúlveda

    2013-08-01

    Full Text Available We report on a patient who presented with cranial nerve VI bilateral paresis, absence of pharyngeal reflex, dysarthria, right tongue deviation, and right facial paralysis. Imaging studies showed an expansive process in the cranial base with clivus and petrous apex osteolysis. A biopsy confirmed the presence of clear cell adenocarcinoma and suspicion of renal tumor metastases. Abdominal imaging studies revealed a mass in the right kidney. Consequently, radiotherapy was performed, and the patient was enrolled in a palliative care and pain control program.

  16. Clear-cell carcinoma of the lung metastatic to the hamate: a case report.

    Science.gov (United States)

    Nissenbaum, M; Kutz, J E; Lister, G D

    1978-01-01

    Metastatic lesions of the hand are uncommon. A report of a solitary metastasis to the hamate seems not to have appeared previously in the literature. A 46-year-old factory worker presented a rare tumor, clear-cell carcinom of the lung, metastasizing to an unusual location, the hamate. The symptoms simulated sympathetic dystrophy and diagnosis was delayed because of the late appearance of radiographic changes over 6 months after symptoms first appeared. Early bone scanning in patients with chronic pain may provide useful information prior to the appearance of X-ray changes.

  17. Decoding the content of recollection within the core recollection network and beyond.

    Science.gov (United States)

    Thakral, Preston P; Wang, Tracy H; Rugg, Michael D

    2017-06-01

    Recollection - retrieval of qualitative information about a past event - is associated with enhanced neural activity in a consistent set of neural regions (the 'core recollection network') seemingly regardless of the nature of the recollected content. Here, we employed multi-voxel pattern analysis (MVPA) to assess whether retrieval-related functional magnetic resonance imaging (fMRI) activity in core recollection regions - including the hippocampus, angular gyrus, medial prefrontal cortex, retrosplenial/posterior cingulate cortex, and middle temporal gyrus - contain information about studied content and thus demonstrate retrieval-related 'reinstatement' effects. During study, participants viewed objects and concrete words that were subjected to different encoding tasks. Test items included studied words, the names of studied objects, or unstudied words. Participants judged whether the items were recollected, familiar, or new by making 'remember', 'know', and 'new' responses, respectively. The study history of remembered test items could be reliably decoded using MVPA in most regions, as well as from the dorsolateral prefrontal cortex, a region where univariate recollection effects could not be detected. The findings add to evidence that members of the core recollection network, as well as at least one neural region where mean signal is insensitive to recollection success, carry information about recollected content. Importantly, the study history of recognized items endorsed with a 'know' response could be decoded with equal accuracy. The results thus demonstrate a striking dissociation between mean signal and multi-voxel indices of recollection. Moreover, they converge with prior findings in suggesting that, as it is operationalized by classification-based MVPA, reinstatement is not uniquely a signature of recollection. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Recollections of parental rejection, self-criticism and depression in suicidality.

    Science.gov (United States)

    Campos, Rui C; Besser, Avi; Blatt, Sidney J

    2013-01-01

    The present study examines whether self-criticism and depressive symptoms mediate the relationship between recollections of parental rejection and suicidality. A community sample of 200 Portuguese adults completed, in counterbalanced order, a socio-demographic questionnaire, the short form of the Inventory for Assessing Memories of Parental Rearing Behaviour (EMBU), the Depressive Experiences Questionnaire (DEQ), the Center for Epidemiologic Studies Depression Scale (CES-D), and reports of any suicide intention and/or ideation and suicide attempts. Structural Equation Modeling (SEM) indicated that recollections of parental rejection are significantly associated with depressive symptoms and suicidality. Recollections of parental rejection are indirectly associated with depressive symptoms and suicidality through self-criticism. The association between self-criticism and suicidality is mediated by depressive symptoms. In addition to a significant direct association between recollections of parental rejection and suicidality, the final model indicated that recollections of parental rejection are significantly associated with self-criticism. That same self-criticism is significantly associated with depressive symptoms which, in turn, are significantly associated with suicidality. Individuals with recollections of parental rejection are at greater risk for suicide ideation and behavior, possibly because such experiences predispose them to intense self-criticism which is a risk factor for depression associated with suicidal ideation and behavior.

  19. Critical teaching incidents. Recollections of deaf college students.

    Science.gov (United States)

    Lang, H G; Dowaliby, F J; Anderson, H P

    1994-03-01

    In interviews with 56 deaf college students, we collected accounts of 839 "critical incidents" describing effective and ineffective teaching. From those incidents, 33 specific teaching characteristics were derived and were analyzed in relation to teacher, student, and course variables. Our primary goal was to identify the teaching characteristics underlying deaf students' recollections about their classroom learning experiences. The most frequently mentioned characteristics are similar to those found in studies of hearing college students, particularly within the domain of Teacher Affect. The teacher's ability to communicate clearly in sign language, however, was not only a characteristic unique to deaf college students but also the most frequently occurring characteristic of effective teaching in this study.

  20. A clear cell adenocarcinoma of the gallbladder with hepatoid differentiation: case report and review of literature

    Directory of Open Access Journals (Sweden)

    Zhang C

    2016-09-01

    Full Text Available Chengsheng Zhang,1,2 Wei Zhang,1,2 Dianbin Mu,1 Xuetao Shi,1 Lei Zhao1,2 1Department of Hepatobiliary Surgery, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Science, 2School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong Province, People’s Republic of China Abstract: An 80-year-old male was referred to our department for a gallbladder mass. He denied any history of alcohol consumption or cholecystitis and smoking. Hepatitis B surface antigen test and antihepatitis C antibody test were found to be negative. Serum carbohydrate antigen 19-9 (CA19-9 and carcinoembryonic antigen were elevated (CA19-9 was 59.92 U/mL and carcinoembryonic antigen was 12.64 ng/mL, whereas alpha-fetoprotein was below the normal limit (2.46 ng/mL. Computed tomography scan revealed a solid mass with measurements of 4.6×5.6×7.1 cm, which nearly filled the whole gallbladder space. Radical cholecystectomy, including segments IV B and V of the liver and lymphadenectomy, was performed. The neoplasm in gallbladder was completely resected, and the patient obtained a negative margin. Histological and immunohistochemical profile suggested a clear cell adenocarcinoma of the gallbladder with hepatoid differentiation. After reviewing the literature, we reported that this case is the first identified case of cell adenocarcinoma of the gallbladder with extensive hepatoid differentiation. However, clinical features of clear cell adenocarcinoma with hepatoid differentiation remain unclear due to the extremely rare incidence. There was no indication of adjuvant chemotherapy and no literature has been reported on the application of chemotherapy. This case showed a promising clinical outcome after curative resection, which indicated that surgical treatment could be potentially considered for suitable patients. Keywords: gallbladder, clear cell adenocarcinoma, hepatoid differentiation 

  1. The electrophysiological correlates of recent and remote recollection.

    Science.gov (United States)

    Roberts, J S; Tsivilis, D; Mayes, A R

    2013-09-01

    Research using event related potentials (ERPs) to explore recognition memory has linked late parietal old/new effects to the recollection of episodic information. In the vast majority of these studies, the retrieval phase immediately follows encoding and consequently, very little is known about the ERP correlates of long term recollection. This is despite the fact that in other areas of the memory literature there is considerable interest in consolidation theories and the way episodic memory changes over time. The present study explored the idea that consolidation and forgetting processes operating over a moderate retention interval can alter the ERP markers of recollection memory. A remember/know test probed memory for stimuli studied either 15 minutes (recent memory) or 1 week (remote memory) prior to the test phase. Results revealed an attenuated late parietal effect for remote compared to recent remember responses, a finding that remained significant even when these recognition judgments were matched for reaction time. Experiments 2a and 2b identified characteristic differences between recent and remote recognition at the behavioural level. The 1 week delay produced an overall decline in recognition confidence and a dramatic loss of episodic detail. These behavioural changes are thought to underlie the ERP effects reported in the first experiment. The results highlight that although the neural basis of memory may exhibit significant changes as the length of the retention interval increases, it is important to consider the extent to which this is a direct effect of time or an indirect effect due to changes in memory quality, such as the amount of detail that can be recollected.

  2. Clear cell variant of diffuse large B-cell lymphoma: a case report

    Directory of Open Access Journals (Sweden)

    Sahatciu-Meka Vjollca

    2011-05-01

    Full Text Available Abstract Introduction Diffuse large B-cell lymphoma is a diffuse proliferation of large neoplastic B lymphoid cells with a nuclear size equal to or exceeding the normal macrophage nuclei. We report a case of a clear cell variant of diffuse large B-cell lymphoma involving a lymph node in the neck, which was clinically suspected of being metastatic carcinoma. Case presentation A 39-year-old Caucasian ethnic Albanian man from Kosovo presented with a rapidly enlarging lymph node in his neck, but he also disclosed B symptoms and fatigue. A cytological aspirate of the lymph node revealed pleomorphic features. Our patient underwent a cervical lymph node biopsy (large excision. The mass was homogeneously fish-flesh, pale white tissue replacing almost the whole structure of the lymph node. The lymph node biopsy showed a partial alveolar growth pattern, which raised clinical suspicion that it was an epithelial neoplasm. With regard to morphological and phenotypic features, we discovered large nodules in diffuse areas, comprising large cells with slightly irregular nuclei and clear cytoplasm admixed with a few mononuclear cells. In these areas, there was high mitotic activity, and in some areas there were macrophages with tangible bodies. Staining for cytokeratins was negative. These areas had the following phenotypes: cluster designation marker 20 (CD20 positive, B-cell lymphoma (Bcl-2-positive, Bcl-6-, CD5-, CD3-, CD21+ (in alveolar patterns, prostate-specific antigen-negative, human melanoma black marker 45-negative, melanoma marker-negative, cytokeratin-7-negative and multiple myeloma marker 1-positive in about 30% of cells, and exhibited a high proliferation index marker (Ki-67, 80%. Conclusion According to the immunohistochemical findings, we concluded that this patient has a clear cell variant of diffuse large B-cell lymphoma of activated cell type, post-germinal center cell origin. Our patient is undergoing R-CHOP chemotherapy treatment.

  3. Clear cell chondrosarcoma calcaneum - a case report and review of literature.

    Science.gov (United States)

    Nagmani, Singh; Rakesh, John; Aditya, Aggarwal; Sandeep, Patel; Arjun, R H H; Debasis, Gochhait

    2015-03-01

    Chondrosarcoma is the second most common primary bone malignancy accounting for 20-25% of all bone sarcomas. However chondrosarcoma of the foot is rare with just a handful of cases being described. Among the subtypes clear cell variant is the rarest and has never been documented in the foot. We present a rare case of clear cell chondrosarcoma of the calcaneum with multiple metastases that was treated at our institute. The patient was a 62-year old male who presented to us with pain and mass in the left hindfoot with difficulty in walking for 2 years and a discharging ulcer over the lateral aspect for 4 months. Radiography showed aggressive, destructive, lytic lesion in the calcaneum with cortical breach and soft tissue invasion. Bone scan and PET-CT revealed multiple bony metastases and lung metastasis. After initial biopsy, patient underwent below knee amputation and has been in remission since the last 18 months. Given the rarity of this tumor in the calcaneum, this report highlights the importance to consider the possibility of this tumor in the calcaneum as an early diagnosis; complete metastatic workup and expeditious management can thus significantly improve prognosis.

  4. Component-Level Electronic-Assembly Repair (CLEAR) Synthetic Instrument Capabilities Assessment and Test Report

    Science.gov (United States)

    Oeftering, Richard C.; Bradish, Martin A.

    2011-01-01

    The role of synthetic instruments (SIs) for Component-Level Electronic-Assembly Repair (CLEAR) is to provide an external lower-level diagnostic and functional test capability beyond the built-in-test capabilities of spacecraft electronics. Built-in diagnostics can report faults and symptoms, but isolating the root cause and performing corrective action requires specialized instruments. Often a fault can be revealed by emulating the operation of external hardware. This implies complex hardware that is too massive to be accommodated in spacecraft. The SI strategy is aimed at minimizing complexity and mass by employing highly reconfigurable instruments that perform diagnostics and emulate external functions. In effect, SI can synthesize an instrument on demand. The SI architecture section of this document summarizes the result of a recent program diagnostic and test needs assessment based on the International Space Station. The SI architecture addresses operational issues such as minimizing crew time and crew skill level, and the SI data transactions between the crew and supporting ground engineering searching for the root cause and formulating corrective actions. SI technology is described within a teleoperations framework. The remaining sections describe a lab demonstration intended to show that a single SI circuit could synthesize an instrument in hardware and subsequently clear the hardware and synthesize a completely different instrument on demand. An analysis of the capabilities and limitations of commercially available SI hardware and programming tools is included. Future work in SI technology is also described.

  5. Serial Pancreas, Liver and Duodenal Metastasis from Renal Clear Cell Cancer: a Case Report

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Case Report In August 2004, a 76-year-old patient was referred to our hospital for progressive loss of appetite, accompanied with mild upper abdominal distention, pain, hiccups and dyspepsia over a recent 3 months period. Reviewing his disease history showed that 16 months before admission (April 2003), he was diagnosed with a recurring left renal clear cell cancer (immunohistochemical staining of tumor cells were positive for CK and Vim, but negative for SMA, HMB-45 and HHF-35, Fig. 1) 10 years after a nephrectomy due to a right renal cancer. At that time, he was treated with photodynamic therapy followed by bio-immunotherapy(interleukine-2 plus lymphokine-activated killer cells). Follow-up by an abdominal CT scan every 3 months showed significant regression of the left renal carcinoma.

  6. Veterinary Students' Recollection Methods for Surgical Procedures

    DEFF Research Database (Denmark)

    Langebaek, Rikke; Tanggaard, Lene; Berendt, Mette

    2016-01-01

    When veterinary students face their first live animal surgeries, their level of anxiety is generally high and this can affect their ability to recall the procedure they are about to undertake. Multimodal teaching methods have previously been shown to enhance learning and facilitate recall; however......, student preferences for recollection methods when translating theory into practice have not been documented. The aim of this study was to investigate veterinary students' experience with recollection of a surgical procedure they were about to perform after using multiple methods for preparation. From...... a group of 171 veterinary students enrolled in a basic surgery course, 26 students were randomly selected to participate in semi-structured interviews. Results showed that 58% of the students used a visual, dynamic method of recollection, mentally visualizing the video they had watched as part...

  7. Sexual experiences in childhood: young adults' recollections.

    Science.gov (United States)

    Larsson, IngBeth; Svedin, Carl-Göran

    2002-06-01

    Childhood sexuality and children's sexual experiences have become increasingly important to study because our knowledge on the impact of sexually abusive experiences on children's developing sexuality has increased. The main aim of this paper was to study aspects of young adults' recollections of their sexual experiences before the age of 13, solitary and shared, mutual as well as coercive. Anonymous questionnaires were answered by 269 final year, senior high-school students, mean age 18.6 years; 82.9% of the students reported solitary sexual experiences and 82.5% had mutual experiences together with another child. Most of the children had their experiences together with a same-age friend. Girls had more same-sex experiences than boys did. Thirteen percent reported coercive experiences where they had been tricked, bribed, threatened, or physically forced into participation. Some children, 8.2%, had coerced another child into participation in sexual activities. The majority thought of their childhood experiences as normal. There were also 6.3% of the respondents who had had inappropriate sexual experiences with someone at least 5 years older, the majority being girls. Gender differences were evident in several respects: girls were more often coerced, they felt more guilt, and they had far less experience of masturbation, whereas boys were somewhat more active in explorative activities on their own as well as with peers. Some kind of coercive sexual experiences appears to be part of growing up for quite a few children, although in general the years before puberty seem to be years of frequent mutual sexual exploration and experimentation.

  8. Process dissociation of familiarity and recollection in children: response deadline affects recollection but not familiarity.

    Science.gov (United States)

    Koenig, Laura; Wimmer, Marina C; Hollins, Timothy J

    2015-03-01

    According to dual-process theories, recollection (slow and associated with contextual details) and familiarity (fast and automatic) are two independent processes underlying recognition memory. An adapted version of the process dissociation paradigm was used to measure recognition memory in 5-, 7-, and 11-year-olds and adults. In Experiment 1, it was found that 5-year-olds already recollect details of items (i.e., number). Recollection increased particularly between 5 and 7 years. Familiarity differed between 5 years and adulthood. In Experiment 2, under limited response time during retrieval, recollection was eliminated in 5-year-olds and reduced across all ages, whereas familiarity was left unaffected. Together, these findings are consistent with dual-process theories of recognition memory and provide support for two processes underlying recognition memory from a developmental perspective.

  9. Early Recollections of First-Borns.

    Science.gov (United States)

    Fakouri, M. Ebrahim; Hafner, James L.

    1984-01-01

    Compared the early recollections of 50 first-borns and 98 later-borns. The first-borns mentioned significantly more nonfamily members, illness/injury, hospital/doctor's office. Later-borns mentioned significantly more siblings than did first-borns. Findings were discussed in the context of Adler's personality theory. (JAC)

  10. Recollections of My Learning and Teaching English

    OpenAIRE

    高井, 収

    2013-01-01

    This paper is a review of my memories of learning and teaching English since I started learning English in Japan. The recollections are basically discussed according to the three following domains: physical, cognitive,and affective since we perceive things by these three domains.

  11. Recollections and Reflections: The American Montessori Society

    Science.gov (United States)

    Gravel, Douglas

    2010-01-01

    In this article, the author shares some of his recollections around the birth of the American Montessori Society (AMS), beginning in the 1950s. He explains the way AMS evolved in its earliest days which reveals something of who its members are now and how they have been part of the 50-year journey. He adds that by recounting the past, members of…

  12. The recollective qualities of adolescents' and adults' narratives about a long-ago tornado.

    Science.gov (United States)

    Bauer, Patricia J; Stark, Emily N; Ackil, Jennifer K; Larkina, Marina; Merrill, Natalie; Fivush, Robyn

    2017-03-01

    The recollective qualities of autobiographical memory are thought to develop over the course of the first two decades of life. We used a 9-year follow-up test of recall of a devastating tornado and of non-tornado-related events from before and after the storm, to compare the recollective qualities of adolescents' (n = 20, ages 11 years, 11 months to 20 years, 8 months) and adults' (n = 14) autobiographical memories. At the time of the tornado, half of the adolescents had been younger than age 6. Nine years after the event, all participants provided evidence that they recall the event of the tornado. Adults also had high levels of recall of the non-tornado-related events. Adolescents recalled proportionally fewer non-tornado-related events; adolescents younger than 6 at the time of the events recalled the fewest non-tornado-related events. Relative to adolescents, adults produced longer narratives. With narrative length controlled, there were few differences in the recollective qualities of adolescents' and adults' narrative reports, especially in the case of the tornado; the recollective qualities were stronger among adolescents older at the time of the events. Overall, participants in both age groups provided evidence of the qualities of recollection that are characteristic of autobiographical memory.

  13. Clear-cell chondrosarcoma of the maxilla Report of a case

    NARCIS (Netherlands)

    Slootweg, P.J.

    1980-01-01

    Clear-cell chondrosarcoma is a variant of chondrosarcoma which is characterized by a typical histomorphology and a very slow rate of growth. A case is presented in which the tumor was located in the maxilla.

  14. Clear-cell variant urothelial carcinoma of the bladder: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Hossein Tezval

    2012-10-01

    Full Text Available Clear cell variants of transitional cell carcinomas (TCC of the bladder are extremely rare tumors. Only 6 cases have been reported until now. We report of a 67 year old man who presented with fast growing tumor disease. While initial diagnosis showed localized bladder tumor, final histopathology revealed pT4, G3, L1 urothelial carcinoma with clear cell differentiation. No more than 14 weeks after initial diagnosis the patient died from multi-organ failure after unsuccessful salvage laparotomy which showed massive tumor burden within the pelvis and peritoneal carcinosis. This case demonstrated an extremely fast tumor growth. Therefore, patients with clear cell urothelial carcinoma should be treated vigorously and without time delay. We present a case of clear cell variant of TCC which exhibited an extremely aggressive behavior. To our knowledge this is the fifth report of this rare disease.

  15. Clear & Simple

    Science.gov (United States)

    ... Cultural Respect Language Access Talking to Your Doctor Research Underway Plain Language Clear & Simple What is Clear & Simple? Clear & Simple ... schedule? A: Pretesting need not be an elaborate, time-consuming research project and depends on: How quickly you work, ...

  16. [Intra-spinal clear cell meningioma. Case report and literature review].

    Science.gov (United States)

    Tuñón-Pitalúa, M C; Molina-Olier, O; Alcalá-Cerra, G; Niño-Hernández, L M; Lozano-Tangua, C F

    2011-02-01

    Clear cell meningioma is a rare variety of meningiomas, occurring frequently at the cerebellopontine angle and spinal canal. A case of a female patient 28 years of age with a complete cauda equina syndrome was described. Magnetic resonance imaging of lumbo-sacral spine revealed a mass lesion occupying the spinal canal from L3 to S1. Subtotal resection was performed and pathological pathological examination revealed a clear cell meningioma. Radiotherapy was indicated, however, it was delayed because we discovered that the patient was pregnant. The recurrence was clinically evident at seven months and a new surgical resection previous complementary radiotherapy was necessary. A systematic review of literature was performed, exposing the behavior of clear cell meningioma in the spinal canal.

  17. A case report of the clear cell variant of gallbladder carcinoma

    Directory of Open Access Journals (Sweden)

    Ravi Maharaj

    2017-01-01

    Conclusion: In these cases, clinical case management should be personalized for increased survival with the possible incorporation of next generation sequencing approaches to guide therapeutic algorithms. We discuss this exceedingly rare case of the clear cell variant of gallbladder carcinoma in detail, highlighting some of the diagnostic, and clinical challenges.

  18. Clear Cell Carcinoma of the Breast: A Rare Breast Cancer Subtype - Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Vilma Ratti

    2015-11-01

    Full Text Available Background: Glycogen-rich clear cell breast carcinoma is a rare histological breast cancer subtype. Its prognosis may vary depending on specific clinical and pathological characteristics such as low grade, strong positivity of estrogen receptor (ER expression and early diagnosis. Case Presentation: We present the case of a 53-year-old woman with a bleeding 10-cm-diameter mass in the left breast. The histological examination showed a poorly differentiated tumor with malignant cells characterized by abundant clear cytoplasm. The diagnosis of clear cell carcinoma was based on the histological characteristics of the tumor, and a nonmammary origin was initially ruled out. The tumor was triple negative [i.e. ER, progesterone receptor (PR and HER2 negative]. Four months after the initial locoregional treatment, the patient developed lung and distant lymph node metastases. Conclusions: Glycogen-rich clear cell carcinoma of the breast is a rare tumor. Early diagnosis, absence of lymph node metastases and ER/PR positivity are associated with a better prognosis, as in other common breast cancer subtypes.

  19. Selective lesion to the entorhinal cortex leads to an impairment in familiarity but not recollection.

    Science.gov (United States)

    Brandt, Karen R; Eysenck, Michael W; Nielsen, Maria Kragh; von Oertzen, Tim J

    2016-04-01

    The present research explored the effects of selective impairment to the entorhinal cortex on the processes of familiarity and recollection. To achieve this objective, the performance of patient MR, who has a selective impairment of the left entorhinal cortex, was compared to that of age and IQ-matched controls. Four experiments tested participants' recognition memory for familiar and unfamiliar faces and words. In all experiments, participants studied lists of items and then completed an old/new recognition test in which they also made remember/know/guess judgements. A fifth experiment tested participants' priming associated with the familiarity process. MR had intact performance in both face recognition experiments as well as having intact performance in pseudoword recognition. Crucially, however, in the familiar word experiment, whilst MR performed similarly to control participants in terms of recollection, she showed a marked impairment in familiarity. Furthermore, she also demonstrated a reversed conceptual priming effect. MR's impairment is both material-specific and selective for previously encountered but not new verbal items (pseudowords). These findings provide the first clear evidence that selective impairment of the entorhinal cortex impairs the familiarity process for familiar verbal material whilst leaving recollection intact. These results suggest the entorhinal cortex does not have attributes reflective of both recollection and familiarity as previously assumed, but rather supports context-free long-term familiarity-based recognition memory.

  20. Spinal clear cell meningioma in a 3-year-old: a case report.

    Science.gov (United States)

    Balogun, James A; Halliday, William; Bouffet, Eric; Kulkarni, Abhaya V

    2013-01-01

    Clear cell meningioma (CCM) is an aggressive meningioma variant with a tendency to early recurrence posing a challenge to its treatment. Although spinal meningiomas are uncommon in children, this rare entity has been described as the most common variant of spinal meningiomas in the pediatric age group. We present the case of a 3-year-old with a confirmed lumbar spine CCM and discuss the problems encountered in the management of this disease.

  1. Test context affects recollection and familiarity ratings: implications for measuring recognition experiences.

    Science.gov (United States)

    Tousignant, Cody; Bodner, Glen E

    2012-06-01

    The binary remember/know task requires participants to dichotomize their subjective recognition experiences into those with recollection and those only with familiarity. Many variables have produced dissociative effects on remember/know judgments. In contrast, having participants make independent recollection/familiarity ratings has consistently produced parallel effects, suggesting the dissociations may be artifacts of using binary judgments. Bodner and Lindsay (2003) reported a test-list context effect with binary judgments: Increased remembering but decreased knowing for a set of critical items tested with a set of less-memorable (vs. more-memorable) items. Here we report a parallel effect of test-list context on recollection and familiarity ratings, induced by a shift in response bias. We argue that independent ratings are preferable to binary judgments because they allow participants to directly report the co-occurrence of recollection and familiarity for each item. Implications for the measurement of self-reported recognition experiences, and for accounts of recognition memory, are discussed.

  2. Familiarity and recollection in heuristic decision making.

    Science.gov (United States)

    Schwikert, Shane R; Curran, Tim

    2014-12-01

    Heuristics involve the ability to utilize memory to make quick judgments by exploiting fundamental cognitive abilities. In the current study we investigated the memory processes that contribute to the recognition heuristic and the fluency heuristic, which are both presumed to capitalize on the byproducts of memory to make quick decisions. In Experiment 1, we used a city-size comparison task while recording event-related potentials (ERPs) to investigate the potential contributions of familiarity and recollection to the 2 heuristics. ERPs were markedly different for recognition heuristic-based decisions and fluency heuristic-based decisions, suggesting a role for familiarity in the recognition heuristic and recollection in the fluency heuristic. In Experiment 2, we coupled the same city-size comparison task with measures of subjective preexperimental memory for each stimulus in the task. Although previous literature suggests the fluency heuristic relies on recognition speed alone, our results suggest differential contributions of recognition speed and recollected knowledge to these decisions, whereas the recognition heuristic relies on familiarity. Based on these results, we created a new theoretical framework that explains decisions attributed to both heuristics based on the underlying memory associated with the choice options.

  3. Case report 423: Clear-cell sarcoma plantar aspect of right foot

    Energy Technology Data Exchange (ETDEWEB)

    Sartoris, D.J.; Resnick, D.; Haghighi, P.

    1987-06-01

    The case is presented of a 65-year-old woman who developed a painful swelling of the plantar aspect of the right foot over a 3-year period. Conventional roentgenograms of the foot showed a large, soft tissue mass on the plantar aspect, with some suggestion of erosion of the adjacent metatarsals. CT studies, however, failed to confirm the presence of any bony abnormalities. At the time of the initial presentation, a biopsy was performed and approximately 3 months later the patient was treated definitely with wide excision of the mass. Histological sections showed the presence of a clear-cell sarcoma - an uncommon lesion mainly confined to the lower extremities and originating either in tendons or aponeurosis. The differential diagnosis, radiologically and clinically was described, and similarly, the differential diagnosis pathologically was also considered. The clinical, pathological and radiological aspects of clear-cell sarcoma of tendon sheath or aponeurosis were discussed in depth and the treatment and prognosis were considered. The authors stress that the importance of the case from a diagnostic imaging perspective lies in the successful use of CT in defining such a soft tissue neoplasm. The ability of CT to determine the extent of involvement of soft tissue and bone by such a lesion is important. Cross-sectional techniques, including magnetic resonance as well as CT, must be the procedure of choice in the definitive diagnosis and treatment of such lesions.

  4. Inclusion criteria for outcomes of studies not clearly reported in Cochrane systematic reviews.

    Science.gov (United States)

    Verbeek, Jos; Ijaz, Sharea; Mischke, Christina

    2017-07-01

    The objective of this study was to survey how outcomes in recent Cochrane reviews were defined and used for inclusion of studies and how this compares with guidance on preventing outcome reporting bias. A survey of Cochrane reviews. We extracted data on the outcomes and how the outcomes were used for inclusion of studies in the review. We included 52 reviews with a mean of 8.4 (standard deviation, 4.3) outcomes. Of all reviews, 47 (90%) used primary and secondary outcomes as the names for their review's outcomes but without further definition. None reported using a core outcome set. Forty reviews (77%) did not explain if they used outcomes for inclusion of studies, 8 (15%) stated that studies were included if they reported either primary or secondary outcomes, 1 (2%) reported that outcomes were not used for inclusion, and for 3 (6%), this was unclear. In a sample of Cochrane reviews, most reviews did not state if outcomes were used for inclusion of studies. Better explanation of inclusion decisions is needed to be able to understand the risk of outcome reporting bias in a review. Consistent guidance in names and definitions for different types of outcomes used in systematic reviews is needed. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Primary renal carcinoid tumor mimicking non-clear cell renal cell carcinoma: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Joo, Lee Hi; Kim, See Hyung; Kim, Mi Jeong; Choe, Mi Sun [Keimyung University School of Medicine, Dongsan Medical Center, Daegu (Korea, Republic of)

    2016-07-15

    Carcinoid tumors are neoplasms with neuroendocrine differentiation, and they are most commonly found in the gastrointestinal and respiratory systems. Primary renal carcinoid tumor has rarely been reported. Here, we present a case of primary renal carcinoid tumor manifesting as a small but a gradually enhancing mass with calcification and a cystic component.

  6. Continuing Assessment of Cleared Personnel in the Military Services. Report 2. Methodology, Analysis, and Results

    Science.gov (United States)

    1991-01-01

    contrast, the sources least likely to report information directly to the security office are dropboxes , chaplains, non-law enforcement databases...the polygraph, informants, subjects, family members, and dropboxes . Respondents were asked whether any additional sources of security-relevant...and Mean Ratings by Collateral Installation Security Managers of the Usefulness of These Sources Mean Source N Rating Dropboxes 1 10.0 Chaplains 1 10.0

  7. Clear retainer

    Directory of Open Access Journals (Sweden)

    Priyakorn Chaimongkol

    2017-01-01

    Full Text Available A clear retainer is a removable retainer that is popular in the present day. Compared with conventional fixed and removable orthodontic retainers, it is a more esthetic, comfortable, and inexpensive appliance. Although several studies have been published about clear retainers, it could be difficult to interpret the results because of the variety of study designs, sample sizes, and research methods. This article is intended to compile the content from previous studies and discuss advantages, disadvantages, fabrication, insertion, and adjustment. Moreover, the effectiveness in maintaining dental position, occlusion, retention protocols, thickness, and survival rate of clear retainers is discussed.

  8. Assessing Recollection and Familiarity in Low Functioning Autism

    Science.gov (United States)

    Ni Chuileann, Susan; Quigley, Jean

    2013-01-01

    Methods to assess recollection and familiarity separately in autism spectrum disorder were recently developed and piloted (Bigham et al. in J Autism Dev Disord 40:878-889, 2010). The preliminary data obtained via these methods showed that whereas recollection was mildly impaired in high functioning autism, familiarity was spared. The current study…

  9. Composite renal cell carcinoma with clear cell renal cell carcinomatous and carcinoid tumoral elements: a first case report.

    Science.gov (United States)

    Bressenot, A; Delaunay, C; Gauchotte, G; Oliver, A; Boudrant, G; Montagne, K

    2010-02-01

    Renal endocrine tumours are extremely rare, and carcinoid tumoral elements in renal cell carcinoma have never been reported. This is the first report of a composite renal cell carcinoma containing a clear cell renal cell carcinoma associated with carcinoid tumoral elements, in a patient with synchronous metastatic disease. In the absence of specific radiological and clinical manifestations, typical morphological features as well as an immunostaining profile of neuroendocrine differentiation were identified by microscopy. Secondary nodal and liver localisations were characterised by carcinoid elements only. Despite antiangiogenic therapy, liver metastasis progressed, suggesting that adjuvant therapy cannot be based on the presence of the clear cell renal cell carcinoma component. In this context, extensive tissue sampling is recommended to reveal the endocrine component that is the most aggressive element of such a composite carcinoma.

  10. Raymond and instantons: some recollections and the use of ADHM

    CERN Document Server

    Altes, Chris P Korthals

    2016-01-01

    After the discovery of the BRST identities in 1974 Raymond spent some two years mostly on instantons. In those years we had a small group at the Centre Physique Th\\'eorique in Marseille discussing the physics and mathematics of instantons. The upshot of our discussions can be found in a set of lectures given by Raymond in Erice in 1977 and a year later in a Physics Reports volume. I present some recollections of that period; mostly how we were influenced by the twistor approach. I discuss the Atiyah-Drinfeld-Hitchin-Manin (ADHM) method to obtain instantons ("calorons") in thermal QCD following earlier work. The building blocks are a prepotential and a gauge invariant propagator. Then I will give surprisingly simple results in terms of these building blocks for the one loop vacuum response to a change in caloron parameters and some physical consequences for the effective action, in particular screening properties.

  11. Raymond and instantons: Some recollections and the use of ADHM

    Science.gov (United States)

    Korthals Altes, Chris P.

    2016-11-01

    After the discovery of the BRST identities in 1974 Raymond spent some two years mostly on instantons. In those years we had a small group at the Centre Physique Théorique in Marseille discussing the physics and mathematics of instantons. The upshot of our discussions can be found in a set of lectures given by Raymond in Erice in 1977 and a year later in a Physics Reports volume. I present some recollections of that period; mostly how we were influenced by the twistor approach. I discuss the Atiyah-Drinfeld-Hitchin-Manin (ADHM) method to obtain instantons ("calorons") in thermal QCD following earlier work. The building blocks are a prepotential and a gauge invariant propagator. Then I will give surprisingly simple results in terms of these building blocks for the one loop vacuum response to a change in caloron parameters and some physical consequences for the effective action.

  12. Raymond and instantons: Some recollections and the use of ADHM

    Directory of Open Access Journals (Sweden)

    Chris P. Korthals Altes

    2016-11-01

    Full Text Available After the discovery of the BRST identities in 1974 Raymond spent some two years mostly on instantons. In those years we had a small group at the Centre Physique Théorique in Marseille discussing the physics and mathematics of instantons. The upshot of our discussions can be found in a set of lectures given by Raymond in Erice in 1977 and a year later in a Physics Reports volume. I present some recollections of that period; mostly how we were influenced by the twistor approach. I discuss the Atiyah–Drinfeld–Hitchin–Manin (ADHM method to obtain instantons (“calorons” in thermal QCD following earlier work. The building blocks are a prepotential and a gauge invariant propagator. Then I will give surprisingly simple results in terms of these building blocks for the one loop vacuum response to a change in caloron parameters and some physical consequences for the effective action.

  13. Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma: Case report with molecular analysis

    Institute of Scientific and Technical Information of China (English)

    Marta Barisella; Andrea Lampis; Federica Perrone; Antonino Carbone

    2008-01-01

    Here we report a new case of clear cell adenocarcinoma (CCA) of the colon in a 54-year-old Caucasian man. Despite of the previous reported cases, the lesion was located in the right colon and was not associated with the conventional adenoma. We performed immunohistochemical and molecular analyses in order to explore whether the CCA had the molecular features generally associated with conventional colorectal carcinoma. The immunohistochemical and molecular analyses showed that the different morphology of CCA does not reflect a distinct biological entity but only an unusual morphological variant of intestinal carcinoma.

  14. SNOW CLEARING

    CERN Multimedia

    Groupe de Transport/Transport Group

    1999-01-01

    In order to facilitate snow-clearing operations, which commence at 4.30 every morning, drivers of CERN vehicles are kindly requested to group their cars together in the car parks. This will greatly help us in our work. Thank you for your co-operation.Transport Group / ST-HMTel. 72202

  15. The effects of healthy aging, amnestic mild cognitive impairment, and Alzheimer's disease on recollection and familiarity: a meta-analytic review.

    Science.gov (United States)

    Koen, Joshua D; Yonelinas, Andrew P

    2014-09-01

    It is well established that healthy aging, amnestic Mild Cognitive Impairment (aMCI), and Alzheimer's Disease (AD) are associated with substantial declines in episodic memory. However, there is still debate as to how two forms of episodic memory - recollection and familiarity - are affected by healthy and pathological aging. To address this issue we conducted a meta-analytic review of the effect sizes reported in studies using remember/know (RK), receiver operating characteristic (ROC) and process dissociation (PD) methods to examine recollection and familiarity in healthy aging (25 published reports), aMCI (9 published reports), and AD (5 published reports). The results from the meta-analysis revealed that healthy aging is associated with moderate-to-large recollection impairments. Familiarity was not impaired in studies using ROC or PD methods but was impaired in studies that used the RK procedure. aMCI was associated with large decreases in recollection whereas familiarity only tended to show a decrease in studies with a patient sample comprised of both single-domain and multiple-domain aMCI patients. Lastly, AD was associated with large decreases in both recollection and familiarity. The results are consistent with neuroimaging evidence suggesting that the hippocampus is critical for recollection whereas familiarity is dependent on the integrity of the surrounding perirhinal cortex. Moreover, the results highlight the relevance of method selection when examining aging, and suggest that familiarity deficits might be a useful behavioral marker for identifying individuals that will develop dementia.

  16. Recollection and familiarity in schizophrenia: a quantitative review.

    Science.gov (United States)

    Libby, Laura A; Yonelinas, Andrew P; Ranganath, Charan; Ragland, J Daniel

    2013-05-15

    Recognition memory judgments can be based on recollection of qualitative information about an earlier study event or on assessments of stimulus familiarity. Schizophrenia is associated with pronounced deficits in overall recognition memory, and these deficits are highly predictive of global functioning. However, the extent to which these deficits reflect impairments in recollection or familiarity is less well understood. In the current article, we reviewed studies that used remember-know-new, process dissociation, and receiver operating characteristic procedures to investigate recollection and familiarity in schizophrenia. We also performed a quantitative reanalysis of these study results to obtain recollection and familiarity estimates that account for methodological differences between studies. Contrary to previous conclusions that recollection is selectively impaired in schizophrenia, we found evidence for both familiarity and recollection deficits across studies, suggesting multi-focal medial temporal lobe and/or prefrontal cortex dysfunction. The familiarity deficits were more variable with frequent small-to-medium rather than medium-to-large effect sizes, suggesting that familiarity could be potentially used as a compensatory ability, whereas recollection is conceptualized as a therapeutic target for new treatment development.

  17. Mural nodules of clear cell carcinoma in a mucinous borderline tumor of the ovary: a case report.

    Science.gov (United States)

    Allende, Daniela S; Drake, Richard D; Chen, Longwen

    2010-04-13

    Mural nodules of ovarian mucinous borderline tumors are rare. In this study, we report a case of mural nodules of clear cell carcinoma in an intestinal type mucinous borderline tumor of the ovary. The patient was a 54-years-old woman presented with back and pelvic pain for 3 months. A right-sided multiloculated ovarian mass approximately 20 cm was identified on the CT scan. CA-125 was moderately elevated. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy and bilateral pelvic and para-aortic lymphadenectomy. Grossly, the right ovarian mass showed a multiloculated cystic mass with mucinous fluid. There were papillations in the internal surface and two mural nodules were seen. Microscopic examination revealed that the cystic mass was an intestinal type borderline mucinous tumor. The mural nodules showed a classic histology of clear cell carcinoma with tubulocystic and papillary growth patterns. This is an extremely rare case of mural nodules of clear cell carcinoma arising in a mucinous borderline tumor.

  18. Right frontal lobe mediation of recollection- and familiarity-based verbal recognition memory: evidence from patients with tumor resections.

    Science.gov (United States)

    Anderson, Nicole D; Davidson, Patrick S R; Mason, Warren P; Gao, Fuqiang; Binns, Malcolm A; Winocur, Gordon

    2011-12-01

    Medial-temporal, parietal, and pFC regions have been implicated in recollection and familiarity, but existing evidence from neuroimaging and patient studies is limited and conflicting regarding the role of specific regions within pFC in these memory processes. We report a study of 20 patients who had undergone resection of right frontal lobe tumors and 20 matched healthy control participants. The location and extent of lesions were traced on the patients' scans. A process dissociation procedure was employed to yield estimates of the contributions of recollection and familiarity in verbal recognition performance. Group comparisons revealed deficits in recollection but not familiarity in the patient group relative to their healthy counterparts. We found a positive relationship between estimates of familiarity and lesion sizes in the right inferior pFC (BA 11, 47) which was significant upon bootstrap resampling. These results are discussed in terms of prior work linking this area to an overextended sense of familiarity.

  19. The Everyday Moral Judge - Autobiographical Recollections of Moral Emotions.

    Science.gov (United States)

    Körner, André; Tscharaktschiew, Nadine; Schindler, Rose; Schulz, Katrin; Rudolph, Udo

    2016-01-01

    Moral emotions are typically elicited in everyday social interactions and regulate social behavior. Previous research in the field of attribution theory identified ought (the moral standard of a given situation or intended goal), goal-attainment (a goal can be attained vs. not attained) and effort (high vs. low effort expenditure) as cognitive antecedents of moral emotions. In contrast to earlier studies, mainly relying on thought experiments, we investigated autobiographical recollections of N = 312 participants by means of an online study. We analyzed a diverse range of moral emotions, i.e., admiration, anger, contempt, indignation, pride, respect, schadenfreude, and sympathy, by using a mixed-method approach. Qualitative and quantitative methods clearly corroborate the important role of ought, goal-attainment, and effort as eliciting conditions of moral emotions. Furthermore, we built categorical systems based on our participants' descriptions of real-life situations, allowing for more fine-grained distinctions between seemingly similar moral emotions. We thus identify additional prerequisites explaining more subtle differences between moral emotion clusters as they emerge from our analyses (i.e., cluster 1: admiration, pride, and respect; cluster 2: anger, contempt, and indignation; cluster 3: schadenfreude and sympathy). Results are discussed in the light of attributional theories of moral emotions, and implications for future research are derived.

  20. Investigating the relationship between implicit and explicit memory: Evidence that masked repetition priming speeds the onset of recollection.

    Science.gov (United States)

    Park, Joanne L; Donaldson, David I

    2016-06-09

    Memory theories assume that unconscious processes influence conscious remembering, but the exact nature of the relationship between implicit and explicit memory remains an open question. Within the context of episodic recognition tests research typical shows that priming impacts behavioral and neural indices of familiarity. By this account, implicit memory leads to enhanced fluency of processing, which is then attributed to 'oldness' in the context of recognition judgments. Recently, however, behavioral and neuroimaging evidence has emerged to suggest that priming can also influence recollection, suggesting that the rate of recollection increases following priming. Here, we examine the relationship between priming and recollection, using Event-Related Potentials (ERPs) to assess changes in the timecourse of processing. Participants studied a series of words, and episodic memory was assessed using a standard item recognition test, but masked repetition priming preceded half of the test cues. Results confirmed that implicit memory was engaged: priming produced robust facilitation of recognition Reaction Times (RTs), with larger effects for studied than unstudied words. Mapping onto the RT data, ERPs recorded during recognition testing over centro-parietal electrodes revealed N400-like priming effects (250-500ms) that were larger in magnitude for studied than unstudied words. More importantly, priming also had a clear impact on explicit memory, as measured by recollection-related left-parietal old/new effects. While old/new effects for unprimed trials were present during the typical 500-800ms latency interval, the old/new effects seen for primed trials were equivalent in magnitude and topography, but onset ~300ms earlier. ERPs reveal that repetition priming speeds the onset of recollection, providing a novel demonstration that unconscious memory processes can have a measureable, functional, influence on conscious remembering.

  1. Some recollections of Porton in World War 1. Commentary.

    Science.gov (United States)

    Garner, J P

    2003-06-01

    Chemical weapons now regularly feature in news reports and the threat from them has become widely recognised by the public at large. Terrorist actions such as the Tokyo subway incident in 1995, coupled with the persistent use of agents such as sulphur mustard and Sarin by the Iraqi regime over the last 20 years in the Iran/Iraq war and against the Kurds of Northern Iraq, make it easy to think that chemical weapons are a new phenomenon. This paper reminds us that many chemical agents were developed during WWI; indeed the first use of a chemical agent was the release of chlorine gas--a choking agent--by the Germans over the battlefields of Ypres in 1915. Porton Down remains at the very heart of chemicals and biological weapons research, albeit in a purely defensive capacity; few of the old buildings remain and the idyllic lifestyle in the Officer's Mess at Idmiston Manor has long since disappeared. These recollections provide a fascinating insight into scientific research at the time of World War I.

  2. Novel scenes improve recollection and recall of words.

    Science.gov (United States)

    Fenker, Daniela B; Frey, Julietta U; Schuetze, Hartmut; Heipertz, Dorothee; Heinze, Hans-Jochen; Duzel, Emrah

    2008-07-01

    Exploring a novel environment can facilitate subsequent hippocampal long-term potentiation in animals. We report a related behavioral enhancement in humans. In two separate experiments, recollection and free recall, both measures of hippocampus-dependent memory formation, were enhanced for words studied after a 5-min exposure to unrelated novel as opposed to familiar images depicting indoor and outdoor scenes. With functional magnetic resonance imaging, the enhancement was predicted by specific activity patterns observed during novelty exposure in parahippocampal and dorsal prefrontal cortices, regions which are known to be linked to attentional orienting to novel stimuli and perceptual processing of scenes. Novelty was also associated with activation of the substantia nigra/ventral tegmental area of the midbrain and the hippocampus, but these activations did not correlate with contextual memory enhancement. These findings indicate remarkable parallels between contextual memory enhancement in humans and existing evidence regarding contextually enhanced hippocampal plasticity in animals. They provide specific behavioral clues to enhancing hippocampus-dependent memory in humans.

  3. Patient recollection of airway suctioning in the ICU : routine versus a minimally invasive procedure

    NARCIS (Netherlands)

    Van de Leur, JP; Zwaveling, JH; Loef, BG; Van der Schans, CP

    Objective: Many patients have an unpleasant recollection of routine endotracheal suctioning after discharge from the Intensive Care Unit (ICU). We hypothesized that through minimally invasive airway suctioning discomfort and stress may be prevented, resulting in less recollection. Design: A

  4. Patient recollection of airway suctioning in the ICU : routine versus a minimally invasive procedure

    NARCIS (Netherlands)

    Van de Leur, JP; Zwaveling, JH; Loef, BG; Van der Schans, CP

    2003-01-01

    Objective: Many patients have an unpleasant recollection of routine endotracheal suctioning after discharge from the Intensive Care Unit (ICU). We hypothesized that through minimally invasive airway suctioning discomfort and stress may be prevented, resulting in less recollection. Design: A prospect

  5. Nonbacterial thrombotic endocarditis with embolic cerebral vascular accidents in a patient with advanced, recurrent clear cell carcinoma of the ovary: A case report.

    Science.gov (United States)

    Liang, Lusha W; Perez, Alexander R; Cangemi, Nicholas A; Young, Robert J; Makker, Vicky

    2016-04-01

    •Nonbacterial thrombotic endocarditis can occur in ovarian clear cell carcinoma.•We report on NBTE-associated embolic cerebrovascular infarcts in advanced OCCC.•Further NBTE-associated embolic events can be prevented with anticoagulant therapy.

  6. [Episodic memory in Alzheimer's disease: decline in recollection and familiarity?].

    Science.gov (United States)

    Simon, Jessica; Bastin, Christine

    2014-01-01

    According to the dual-process recognition models, the retrieval of information from long-term memory is supported by recollection and familiarity. Alzheimer's disease is consistently found to affect recollection. As for familiarity, however, no consensus has been reached so far. Some studies are in favor of an early impairment of familiarity, while others are in favor of a preservation of familiarity in the mild and moderate stages of the disease. This lack of consensus can be partly explained by methodological differences between studies. We discuss three methodological dimensions: the type of recognition test, the type of paradigm for estimating familiarity and recollection, and the nature of the material used. These differences reveal the complex nature of familiarity which would be underlied by different mechanisms that may be -selectively altered or preserved in the disease.

  7. Recollection deficiencies in patients with major depressive disorder.

    Science.gov (United States)

    Drakeford, Justine L; Edelstyn, Nicola M J; Oyebode, Femi; Srivastava, Shrikant; Calthorpe, William R; Mukherjee, Tirthankar

    2010-02-28

    Neuropsychological research suggests that recognition memory (RM) and recall memory are impaired in patients with a major depressive disorder or a dysphoric mood state. This study examines the proposal that abnormalities in recollection (a form of recall) result from a breakdown in frontal strategic memory processes involved in encoding and retrieval, and executive functions linked to reality monitoring, planning, problem-solving, reasoning and decision-making. We investigated two predictions arising from this theory. Firstly, patients diagnosed with a major depressive disorder (MDD) will display a dissociation between (deficient) recollection and (preserved) familiarity. Secondly, if recollection impairments are indicative of a breakdown in prefrontal strategic memory processes which are dependent, at least in part, on executive processes, then an explicit correlational approach predicts that recollection will be positively associated with the severity of executive dysfunction in MDD patients. The remember/know paradigm was used to investigate RM for words and neutral faces in 16 MDD patients and 16 healthy volunteers, matched for age, gender and estimates of premorbid IQ. Measures of executive function included working memory, reasoning and decision-making. Applying the Dual Process Signal Detection interpretation of the remember/know data, the MDD group displayed significant impairments in RM and recollection rates for both verbal and neutral facial memoranda. In contrast, familiarity-aware rates were preserved. There was no evidence of executive dysfunction in the patient group, and little evidence that recollection rates correlated with executive function. Furthermore, a single process signal detection approach suggested that the MDD patients displayed a reduction in sensitivity for RM and remember rates but not know responses. The criteria for detecting studied from unstudied items, and remembering from knowing, were the same in both patient and healthy

  8. Assessing Recollection and Familiarity in Autistic Spectrum Disorders: Methods and Findings

    Science.gov (United States)

    Bigham, Sally; Boucher, Jill; Mayes, Andrew; Anns, Sophie

    2010-01-01

    We hypothesise that of the two processes underlying declarative memory, recollection is impaired in high-functioning autism (HFA) whereas recollection and familiarity are impaired in low-functioning autism (LFA). Testing these hypotheses necessitates assessing recollection and familiarity separately. However, this is difficult, because both…

  9. Levels of Processing and the Cue-Dependent Nature of Recollection

    Science.gov (United States)

    Mulligan, Neil W.; Picklesimer, Milton

    2012-01-01

    Dual-process models differentiate between two bases of memory, recollection and familiarity. It is routinely claimed that deeper, semantic encoding enhances recollection relative to shallow, non-semantic encoding, and that recollection is largely a product of semantic, elaborative rehearsal. The present experiments show that this is not always the…

  10. Salmon Supplementation Studies in Idaho Rivers; Field Activities Conducted on Clear and Pete King Creeks, 2001 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Gass, Carrie; Olson, Jim M. (US Fish and Wildlife Service, idaho Fishery Resource Office, Ahsahka, ID)

    2004-11-01

    In 2001 the Idaho Fisheries Resource Office continued as a cooperator on the Salmon Supplementation Studies in Idaho Rivers (ISS) project on Pete King and Clear creeks. Data relating to supplementation treatment releases, juvenile sampling, juvenile PIT tagging, brood stock spawning and rearing, spawning ground surveys, and snorkel surveys were used to evaluate project data points and augment past data. Due to low adult spring Chinook returns to Kooskia National Fish Hatchery (KNFH) in brood year 1999 there was no smolt supplementation treatment release into Clear Creek in 2001. A 17,014 spring Chinook parr supplementation treatment (containing 1000 PIT tags) was released into Pete King Creek on July 24, 2001. On Clear Creek, there were 412 naturally produced spring Chinook parr PIT tagged and released. Using juvenile collection methods, Idaho Fisheries Resource Office staff PIT tagged and released 320 naturally produced spring Chinook pre-smolts on Clear Creek, and 16 natural pre-smolts on Pete King Creek, for minimum survival estimates to Lower Granite Dam. There were no PIT tag detections of brood year 1999 smolts from Clear or Pete King creeks. A total of 2261 adult spring Chinook were collected at KNFH. Forty-three females were used for supplementation brood stock, and 45 supplementation (ventral fin-clip), and 45 natural (unmarked) adults were released upstream of KNFH to spawn naturally. Spatial and temporal distribution of 37 adults released above the KNFH weir was determined through the use of radio telemetry. On Clear Creek, a total of 166 redds (8.2 redds/km) were observed and data was collected from 195 carcasses. Seventeen completed redds (2.1 redds/km) were found, and data was collected data from six carcasses on Pete King Creek.

  11. Discomfort and factual recollection in intensive care unit patients

    NARCIS (Netherlands)

    van de Leur, JP; van der Schans, CP; Loef, BG; Deelman, BG; Geertzen, JHB; Zwaveling, JH

    2004-01-01

    Introduction A stay in the intensive care unit (ICU), although potentially life-saving, may cause considerable discomfort to patients. However, retrospective assessment of discomfort is difficult because recollection of stressful events may be impaired by sedation and severe illness during the ICU

  12. Bruno Pontecorvo selected scientific works recollections on Bruno Pontecorvo

    CERN Document Server

    Pontecorvo, Bruno; Blokhintseva, T D; Cifarelli, L; Matveev, V A; Pokrovskaya, I G; Sapozhnikov, M G

    2013-01-01

    To celebrate the 100th anniversary of the birth of Bruno Pontecorvo, the Italian Physical Society (Società Italiana di Fisica, SIF) in Italy and the Joint Institute for Nuclear Research (JINR, Dubna) in Russia have decided to publish a new expanded edition of the volume "B. Pontecorvo Selected Scientific Works - Recollections on B. Pontecorvo" (Società Italiana di Fisica, Bologna, 1997).

  13. Assessing the Dissociability of Recollection and Familiarity in Recognition Memory

    Science.gov (United States)

    Pratte, Michael S.; Rouder, Jeffrey N.

    2012-01-01

    Recognition memory is often modeled as constituting 2 separate processes, recollection and familiarity, rather than as constituting a single process mediated by a generic latent strength. One way of stating evidence for the more complex 2-process model is to show dissociations with select manipulations, in which one manipulation affects…

  14. The Sensorimotor Contributions to Implicit Memory, Familiarity, and Recollection

    Science.gov (United States)

    Topolinski, Sascha

    2012-01-01

    The sensorimotor contributions to memory for prior occurrence were investigated. Previous research has shown that both implicit memory and familiarity draw on gains in stimulus-related processing fluency for old, compared with novel, stimuli, but recollection does not. Recently, it has been demonstrated that processing fluency itself resides in…

  15. Myth and Archetype in Recollections of Things to Come

    Directory of Open Access Journals (Sweden)

    Robert K. Anderson

    1985-01-01

    Full Text Available According to Elena Garro, "the great writer will be the one who presents the Mexican as a universal being." In her novel Recollections of Things to Come she achieves this goal primarily through an incessant infusion of mythic and archetypal motifs, elements that constitute the cornerstone of this study.

  16. Discomfort and factual recollection in intensive care unit patients

    NARCIS (Netherlands)

    van de Leur, JP; van der Schans, CP; Loef, BG; Deelman, BG; Geertzen, JHB; Zwaveling, JH

    2004-01-01

    Introduction A stay in the intensive care unit (ICU), although potentially life-saving, may cause considerable discomfort to patients. However, retrospective assessment of discomfort is difficult because recollection of stressful events may be impaired by sedation and severe illness during the ICU s

  17. Recollection- and familiarity-based decisions reflect memory strength

    Directory of Open Access Journals (Sweden)

    Martin Wiesmann

    2008-05-01

    Full Text Available We used event-related fMRI to investigate whether recollection- and familiarity-based memory judgments are modulated by the degree of visual similarity between old and new art paintings. Subjects performed a flower detection task, followed by a Remember/Know/New surprise memory test. The old paintings were randomly presented with new paintings, which were either visually similar or visually different. Consistent with our prediction, subjects were significantly faster and more accurate to reject new, visually different paintings than new, visually similar ones. The proportion of false alarms, namely remember and know responses to new paintings, was significantly reduced with decreased visual similarity. The retrieval task evoked activation in multiple visual, parietal and prefrontal regions, within which remember judgments elicited stronger activation than know judgments. New, visually different paintings evoked weaker activation than new, visually similar items in the intraparietal sulcus. Contrasting recollection with familiarity revealed activation predominantly within the precuneus, where the BOLD response elicited by recollection peaked significantly earlier than the BOLD response evoked by familiarity judgments. These findings suggest that successful memory retrieval of pictures is mediated by activation in a distributed cortical network, where memory strength is manifested by differential hemodynamic profiles. Recollection- and familiarity-based memory decisions may therefore reflect strong memories and weak memories, respectively.

  18. Narrative report: Tule Lake, Lower Klamath, Upper Klamath, and Clear Lake National Wildlife Refuges: January through April, 1954

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1954. The report begins by summarizing...

  19. Narrative report: May through August, 1958: Tule Lake, Lower Klamath, Upper Klamath, Clear Lake National Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1958. The report begins by summarizing the...

  20. Narrative report: January through April, 1959: Tule Lake, Lower Klamath, Upper Klamath, and Clear Lake National Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1959. The report begins by summarizing the...

  1. Narrative report: Tule Lake, Lower Klamath, Upper Klamath, and Clear Lake National Wildlife Refuges: September - December, 1955

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1955. The report begins by...

  2. Narrative report: May through August, 1957: Tule Lake, Lower Klamath, Upper Klamath, Clear Lake National Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1957. The report begins by summarizing the...

  3. Narrative report: Tule Lake, Lower Klamath, Upper Klamath and Clear Lake National Wildlife Refuges: September - December, 1956

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1956. The report begins by...

  4. Narrative report: Tule Lake, Lower Klamath, Upper Klamath, and Clear Lake National Wildlife Refuges: January, February, March, April, 1955

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1955. The report begins by summarizing the...

  5. Narrative report: January through April, 1957: Tule Lake, Lower Klamath, Upper Klamath, and Clear Lake National Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1957. The report begins by summarizing the...

  6. Narrative report: May through August, 1959: Tule Lake, Lower Klamath, Upper Klamath, Clear Lake National Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1959. The report begins by summarizing the...

  7. Narrative report: September through December, 1959: Tule Lake, Lower Klamath, Upper Klamath, Clear Lake, Klamath Marsh National Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1959. The report begins by...

  8. Narrative report: January through April, 1960: Tule Lake, Lower Klamath, Upper Klamath, Clear Lake, Klamath Marsh National Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1960. The report begins by summarizing the...

  9. Treatment of Cerebral Apoplectic Pseudobulbar Palsy with Consciousness-Restoring & Obstruction-Clearing Needling Technique: A Report of 300 Cases

    Institute of Scientific and Technical Information of China (English)

    JIANG Ge-li; WANG Guo-hua; WANG Hong-yun; HAN Chou-ping

    2003-01-01

    Objective: To study the therapeutic effect of treating apoplectic pscudobulbar paralysis with acupunc -ture. Method: Consciousness-restoring & obstruction -clearing needling technique and points Fengchi (GB 20),Yifeng (TE 17), Wangu (GB 12), Neiguan (PC 6),Shuigou (GV 26), Sanyinjiao (SP 6), Shanglianquan (Ex-HN), Jinjin (Ex-HN 12), Yuye (Ex-HN 13) and Baihui (GV 20) were selected to treat 300 cases of apoplectic pseudobulbar paralysis. Result: Cure: 189cases, marked effect: 71 cases, effective: 32 cases, no effect: 8 cases and the whole effective rate is 97.3%.Conclusion: Consciousness-restoring & obstruction-clea ring needling technique is effective in treating apoplectic pscudobulbar paralysis.

  10. Cognitive training-related changes in hippocampal activity associated with recollection in older adults.

    Science.gov (United States)

    Kirchhoff, Brenda A; Anderson, Benjamin A; Smith, Staci E; Barch, Deanna M; Jacoby, Larry L

    2012-09-01

    Impairments in the ability to recollect specific details of personally experienced events are one of the main cognitive changes associated with aging. Cognitive training can improve older adults' recollection. However, little is currently known regarding the neural correlates of these training-related changes in recollection. Prior research suggests that the hippocampus plays a central role in supporting recollection in young and older adults, and that age-related changes in hippocampal function may lead to age-related changes in recollection. The present study investigated whether cognitive training-related increases in older adults' recollection are associated with changes in their hippocampal activity during memory retrieval. Older adults' hippocampal activity during retrieval was examined before and after they were trained to use semantic encoding strategies to intentionally encode words. Training-related changes in recollection were positively correlated with training-related changes in activity for old words in the hippocampus bilaterally. Positive correlations were also found between training-related changes in activity in prefrontal and left lateral temporal regions associated with self-initiated semantic strategy use during encoding and training-related changes in right hippocampal activity associated with recollection during retrieval. These results suggest that cognitive training-related improvements in older adults' recollection can be supported by changes in their hippocampal activity during retrieval. They also suggest that age differences in cognitive processes engaged during encoding are a significant contributor to age differences in recollection during retrieval.

  11. Narcissism and childhood recollections: a quantitative test of psychoanalytic predictions.

    Science.gov (United States)

    Otway, Lorna J; Vignoles, Vivian L

    2006-01-01

    Different psychotherapeutic theories provide contradictory accounts of adult narcissism as the product of either parental coldness or excessive parental admiration during childhood. Yet, none of these theories has been tested systematically in a nonclinical sample. The authors compared four structural equation models predicting overt and covert narcissism among 120 United Kingdom adults. Both forms of narcissism were predicted by both recollections of parental coldness and recollections of excessive parental admiration. Moreover, a suppression relationship was detected between these predictors: The effects of each were stronger when modeled together than separately. These effects were found after controlling for working models of attachment; covert narcissism was predicted also by attachment anxiety. This combination of childhood experiences may help to explain the paradoxical combination of grandiosity and fragility in adult narcissism.

  12. Is the parietal lobe necessary for recollection in humans?

    Science.gov (United States)

    Simons, Jon S; Peers, Polly V; Hwang, David Y; Ally, Brandon A; Fletcher, Paul C; Budson, Andrew E

    2008-03-07

    An intriguing puzzle in cognitive neuroscience over recent years has been the common observation of parietal lobe activation in functional neuroimaging studies during the performance of human memory tasks. These findings have surprised scientists and clinicians because they challenge decades of established thinking that the parietal lobe does not support memory function. However, direct empirical investigation of whether circumscribed parietal lobe lesions might indeed be associated with human memory impairment has been lacking. Here we confirm using functional magnetic resonance imaging that significant parietal lobe activation is observed in healthy volunteers during a task assessing recollection of the context in which events previously occurred. However, patients with parietal lobe lesions that overlap closely with the regions activated in the healthy volunteers nevertheless exhibit normal performance on the same recollection task. Thus, although the processes subserved by the human parietal lobe appear to be recruited to support memory function, they are not a necessary requirement for accurate remembering to occur.

  13. Recollecting landscapes: landscape photography as a didactic tool

    OpenAIRE

    NOTTEBOOM, Bruno

    2011-01-01

    The paper investigates the subject of the image and its presentation by reinterpreting the rephotographic survey project Recollecting Landscapes. The aim of this project was to document a century of landscape transformation in Belgium through a series of sixty landscapes successively photographed in the early twentieth century, in 1980 and in 2003. Each stage was characterized by an explicit didactic agenda: the vulgarization of geographical and botanical aspects of the Belgian landscape by b...

  14. Processing fluency hinders subsequent recollection: An electrophysiological study

    Directory of Open Access Journals (Sweden)

    Bingbing eLi

    2015-06-01

    Full Text Available Although many behavioural studies have investigated the effect of processing fluency on subsequent recognition memory, little research has examined the neural mechanism of this phenomenon. The present study aimed to explore the electrophysiological correlates of the effects of processing fluency on subsequent recognition memory by using an event-related potential (ERP approach. The masked repetition priming paradigm was used to manipulate processing fluency in the study phase, and the R/K paradigm was utilised to investigate which recognition memory process (familiarity or recollection was affected by processing fluency in the test phase. Converging behavioural and ERP results indicated that increased processing fluency impaired subsequent recollection. Results from the analysis of ERP priming effects in the study phase indicated that increased perceptual processing fluency of object features, reflected by the N/P 190 priming effect, can hinder encoding activities, reflected by the LPC priming effect, which leads to worse subsequent recollection based recognition memory. These results support the idea that processing fluency can influence subsequent recognition memory and provide a potential neural mechanism underlying this effect. However, further studies are needed to examine whether processing fluency can affect subsequent familiarity.

  15. Impaired recollection of visual scene details in adults with autism spectrum conditions.

    Science.gov (United States)

    Cooper, Rose A; Plaisted-Grant, Kate C; Hannula, Deborah E; Ranganath, Charan; Baron-Cohen, Simon; Simons, Jon S

    2015-08-01

    Subtle memory deficits observed in autism spectrum conditions (ASC) have often been characterized as reflecting impaired recollection and it has been proposed that a relational binding deficit may underlie the recollection impairment. However, subjective recollection and relational binding have not been measured within the same task in ASC to date and it is unclear whether a relational binding deficit can provide a full account of recollection impairments in ASC. Relational memory has also not been compared with item memory when the demands of the 2 tasks are comparable. To assess recollection, relational memory, and item memory within a single task in ASC, 24 adults with ASC and 24 typically developed adults undertook a change detection memory task that assessed recollection of item-specific and spatial details. Participants studied rendered indoor and outdoor scenes and, in a subsequent recognition memory test, distinguished scenes that had not changed from those that had either undergone an item change (a different item exemplar) or a relational (spatial) change, which was followed by a subjective recollection judgment. The ASC group identified fewer item changes and spatial changes, to a similar degree, which was attributable to a specific reduction in recollection-based recognition relative to the control group. These findings provide evidence that recollection deficits in ASC may not be driven entirely by a relational binding deficit.

  16. Clear cell adenocarcinoma of the cervix in second generation young women who are without maternal exposure to diethylstilbestrol: A case report

    Directory of Open Access Journals (Sweden)

    Tanitra Tantitamit

    2017-05-01

    Full Text Available Clear cell adenocarcinoma of the cervix (CCAC is a rare type of gynecological cancer. The risk factors and pathogenesis have yet to be clearly determined. This is a case report of a 19-year-old woman, who was never exposed to DES from her mother, who had gone for an examination for vaginal bleeding. A polypoid mass measured at 3 cm presenting in her cervix was discovered. Histological diagnosis following cervical biopsy proved the tumor to be a clear cell carcinoma. The patient was then referred to our hospital. A loop electrosurgical excision procedure (LEEP was done and the pathological diagnosis was confirmed for clear cell carcinoma with a positive endocervical margin. Radical hysterectomy, pelvic lymphadenectomy and incidental appendectomy were achieved without any complications. The microscopic findings had revealed no residual tumor. The patient did not require adjuvant treatment. No sign of recurrence has been detected throughout 6 months of follow-up. We have performed the literature review on the clinical presentation, pathogenesis, pathology, diagnosis, treatment, and prognosis of this unusual tumor.

  17. Recognition Memory and the Hippocampus: A Test of the Hippocampal Contribution to Recollection and Familiarity

    Science.gov (United States)

    Jeneson, Annette; Kirwan, C. Brock; Hopkins, Ramona O.; Wixted, John T.; Squire, Larry R.

    2010-01-01

    It has been suggested that the hippocampus selectively supports recollection and that adjacent cortex in the medial temporal lobe can support familiarity. Alternatively, it has been suggested that the hippocampus supports both recollection and familiarity. We tested these suggestions by assessing the performance of patients with hippocampal…

  18. Recognition Memory: Adding a Response Deadline Eliminates Recollection but Spares Familiarity

    Science.gov (United States)

    Sauvage, Magdalena M.; Beer, Zachery; Eichenbaum, Howard

    2010-01-01

    A current controversy in memory research concerns whether recognition is supported by distinct processes of familiarity and recollection, or instead by a single process wherein familiarity and recollection reflect weak and strong memories, respectively. Recent studies using receiver operating characteristic (ROC) analyses in an animal model have…

  19. Triple dissociation in the medial temporal lobes: recollection, familiarity, and novelty.

    NARCIS (Netherlands)

    Daselaar, S.M.; Fleck, M.S.; Cabeza, R.

    2006-01-01

    Memory for past events may be based on retrieval accompanied by specific contextual details (recollection) or on the feeling that an item is old (familiarity) or new (novelty) in the absence of contextual details. There are indications that recollection, familiarity, and novelty involve different me

  20. Improving Operations Management Concept Recollection via the Zarco Experiential Learning Activity

    Science.gov (United States)

    Polito, Tony; Kros, John; Watson, Kevin

    2004-01-01

    In this study, the authors investigated the effect of Zarco, an operations management "mock factory" experiential learning activity, on student recollection of operations management concepts. Using a number of single-factor and multiple-factor analyses of variance, the authors compared the recollection of students treated with the Zarco activity…

  1. The Large Hadron Collider, a personal recollection

    CERN Document Server

    Evans, L

    2014-01-01

    The construction of the Large Hadron Collider (LHC) has been a massive endeavor spanning almost 30 years from conception to commissioning. Building the machine with the highest possible energy (7 TeV) in the existing LEP tunnel of 27 km circumference and with a tunnel diameter of only 3.8m has required considerable innovation. The first was the development of an idea first proposed by Bob Palmer at Brookhaven National Laboratory in 1978, where the two rings are integrated into a single magnetic structure. This compact 2-in-1 structure was essential for the LHC due to both the limited space available in the existing Large Electron-Positron collider tunnel and the cost. The second innovation was the bold move to use superfluid helium cooling on a massive scale, which was imposed by the need to achieve a high (8.3 T) magnetic field using an affordable Nb-Ti superconductor. In this article, no attempt is made to give a comprehensive review of the machine design. This can be found in the LHC Design Report {[}1], w...

  2. Effect of frontal lobe lesions on the recollection and familiarity components of recognition memory.

    Science.gov (United States)

    MacPherson, Sarah E; Bozzali, Marco; Cipolotti, Lisa; Dolan, Raymond J; Rees, Jeremy H; Shallice, Tim

    2008-11-01

    Single-process theories assume that familiarity is the sole influence on recognition memory with decisions being made as a continuous process. Dual-process theories claim that recognition involves both recollection and familiarity processes with recollection as a threshold process. Although, the frontal lobes of the brain play an important role in recognition memory, few studies have examined the effect of frontal lobe lesions on recollection and familiarity. In the current study, the nonverbal recognition memory of 24 patients with focal frontal lesions due to tumour or stroke was examined. Recollection and familiarity were estimated using the receiver operating characteristic (ROC) method. A secondary analysis was also conducted using standard signal detection theory methodology. Both analyses led to similar conclusions where only the familiarity component of recognition memory was impaired in frontal patients compared to healthy controls whilst the recollection-type (or variance ratio) processes remained intact.

  3. Illusory Recollection: The Compelling Subjective Remembrance of Things that Never Happened. Insights from the DRM Paradigm

    Directory of Open Access Journals (Sweden)

    Hedwige Dehon

    2012-09-01

    Full Text Available Illusory recollection is the subjective detailed feeling of remembering that sometimes accompanies false remembering of events that never happened (e.g., high confidence, “Remember” judgements, or even remembrance of precise details supposedly associated with the false event. In this review, typical illusory recollection measures obtained from laboratory studies will be depicted, with a focus on the DRM paradigm (Deese, 1959; Roediger & McDermott, 1995, one of the most largely used procedures to study memory distortion and its associated illusory recollection. The theoretical explanations of illusory recollection will be described and contrasted in light of factors affecting the phenomenon, in order to show their strengths and limits. Although the focus on the origins of illusory recollection is relatively recent, overall, this review suggests that DRM false memories can be an excellent tool to study this phenomenon under controlled conditions and to gain insights on false memories occurring in everyday life.

  4. Eye movements during the recollection of text information reflect content rather than the text itself

    DEFF Research Database (Denmark)

    Traub, Franziska; Johansson, Roger; Holmqvist, Kenneth

    Several studies have reported that spontaneous eye movements occur when visuospatial information is recalled from memory. Such gazes closely reflect the content and spatial relations from the original scene layout (e.g., Johansson et al., 2012). However, when someone has originally read a scene...... description, the memory of the physical layout of the text itself might compete with the memory of the spatial arrangement of the described scene. The present study was designed to address this fundamental issue by having participants read scene descriptions that where manipulated to be either congruent....... Recollection was performed orally while gazing at a blank screen. Results demonstrate that participant’s gaze patterns during recall more closely reflect the spatial layout of the scene than the physical locations of the text. Memory data provide evidence that mental models representing either the situation...

  5. Component-Level Electronic-Assembly Repair (CLEAR) Analysis of the Problem Reporting and Corrective Action (PRACA) Database of the International Space Station On-Orbit Electrical Systems

    Science.gov (United States)

    Oeftering, Richard C.; Bradish, Martin A.; Juergens, Jeffrey R.; Lewis, Michael J.

    2011-01-01

    The NASA Constellation Program is investigating and developing technologies to support human exploration of the Moon and Mars. The Component-Level Electronic-Assembly Repair (CLEAR) task is part of the Supportability Project managed by the Exploration Technology Development Program. CLEAR is aimed at enabling a flight crew to diagnose and repair electronic circuits in space yet minimize logistics spares, equipment, and crew time and training. For insight into actual space repair needs, in early 2008 the project examined the operational experience of the International Space Station (ISS) program. CLEAR examined the ISS on-orbit Problem Reporting and Corrective Action database for electrical and electronic system problems. The ISS has higher than predicted reliability yet, as expected, it has persistent problems. A goal was to identify which on-orbit electrical problems could be resolved by a component-level replacement. A further goal was to identify problems that could benefit from the additional diagnostic and test capability that a component-level repair capability could provide. The study indicated that many problems stem from a small set of root causes that also represent distinct component problems. The study also determined that there are certain recurring problems where the current telemetry instrumentation and built-in tests are unable to completely resolve the problem. As a result, the root cause is listed as unknown. Overall, roughly 42 percent of on-orbit electrical problems on ISS could be addressed with a component-level repair. Furthermore, 63 percent of on-orbit electrical problems on ISS could benefit from additional external diagnostic and test capability. These results indicate that in situ component-level repair in combination with diagnostic and test capability can be expected to increase system availability and reduce logistics. The CLEAR approach can increase the flight crew s ability to act decisively to resolve problems while reducing

  6. Not so close but still extremely loud: recollection of the World Trade Center terror attack and previous hurricanes moderates the association between exposure to hurricane Sandy and posttraumatic stress symptoms.

    Science.gov (United States)

    Palgi, Yuval; Shrira, Amit; Hamama-Raz, Yaira; Palgi, Sharon; Goodwin, Robin; Ben-Ezra, Menachem

    2014-05-01

    The present study examined whether recollections of the World Trade Center (WTC) terror attack and previous hurricanes moderated the relationship between exposure to Hurricane Sandy and related posttraumatic stress disorder (PTSD) symptoms. An online sample of 1000 participants from affected areas completed self-report questionnaires a month after Hurricane Sandy hit the East Coast of the United States. Participants reported their exposure to Hurricane Sandy, their PTSD symptoms, and recollections of the WTC terror attack and previous hurricanes elicited due to Hurricane Sandy. Exposure to Hurricane Sandy was related to PTSD symptoms among those with high level of recollections of the WTC terror attack and past hurricanes, but not among those with low level of recollections. The aftermath of exposure to Hurricane Sandy is related not only to exposure, but also to its interaction with recollections of past traumas. These findings have theoretical and practical implications for practitioners and health policy makers in evaluating and interpreting the impact of past memories on future natural disasters. This may help in intervention plans of social and psychological services. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Exploring recollection and familiarity impairments in Parkinson's disease.

    Science.gov (United States)

    Rodríguez, Lucía-Azahara; Algarabel, Salvador; Escudero, Joaquín

    2014-01-01

    There is conflicting evidence on whether patients diagnosed with Parkinson's disease (PD) have cognitive deficits associated with episodic memory and particularly with recognition memory. The aim of the present study was to explore whether PD patients exhibit deficits in recollection and familiarity, the two processes involved in recognition. A sample of young healthy participants (22) was tested to verify that the experimental tasks were useful estimators of recognition processes. Two further samples--one of elderly controls (16) and one of PD patients (20)--were the main focus of this research. All participants were exposed to an associative recognition test aimed at estimating recollection followed by a two-alternative forced-choice (2AFC) test designed to estimate familiarity. The analyses showed a deficit in associative recognition in PD patients and no difference between elderly controls and PD patients in the 2AFC test. By contrast, young healthy participants were better than elderly controls and PD patients in both components of recognition. Further analyses of results of the 2AFC test indicated that the measure chosen to estimate conceptual familiarity was adequate.

  8. Beta-adrenergic Blockade at Memory Encoding, but Not Retrieval, Decreases the Subjective Sense of Recollection.

    Science.gov (United States)

    Rimmele, Ulrike; Lackovic, Sandra F; Tobe, Russell H; Leventhal, Bennett L; Phelps, Elizabeth A

    2016-06-01

    Humans remember emotional events not only better but also exhibit a qualitatively distinct recollective experience-that is, emotion intensifies the subjective vividness of the memory, the sense of reliving the event, and confidence in the accuracy of the memory [Phelps, E. A., & Sharot, T. How (and why) emotion enhances the subjective sense of recollection. Current Directions in Psychological Science, 17, 147-152, 2008]. Although it has been demonstrated that activation of the beta-adrenergic system, linked to increases in stress hormone levels and physiological arousal, mediates enhanced emotional memory accuracy, the mechanism underlying the increased subjective sense of recollection is unknown. Behavioral evidence suggests that increased arousal associated with emotional events, either at encoding or retrieval, underlies their increased subjective sense of recollection. Using a double-blind, placebo-controlled, within-subject design, we showed that reducing arousal at encoding through oral intake of 80-mg of the beta-adrenergic receptor antagonist propranolol decreases the subjective sense of recollection for both negative and neutral stimuli 24 hr later. In contrast, administration of propranolol before memory retrieval did not alter the subjective sense of recollection. These results suggest that the neurohormonal changes underlying increased arousal at the time of memory formation, rather than the time of memory retrieval, modulate the subjective sense of recollection.

  9. How emotion strengthens the recollective experience: a time-dependent hippocampal process.

    Directory of Open Access Journals (Sweden)

    Tali Sharot

    Full Text Available Emotion significantly strengthens the subjective recollective experience even when objective accuracy of the memory is not improved. Here, we examine if this modulation is related to the effect of emotion on hippocampal-dependent memory consolidation. Two critical predictions follow from this hypothesis. First, since consolidation is assumed to take time, the enhancement in the recollective experience for emotional compared to neutral memories should become more apparent following a delay. Second, if the emotion advantage is critically dependent on the hippocampus, then the effects should be reduced in amnesic patients with hippocampal damage. To test these predictions we examined the recollective experience for emotional and neutral photos at two retention intervals (Experiment 1, and in amnesics and controls (Experiment 2. Emotional memories were associated with an enhancement in the recollective experience that was greatest after a delay, whereas familiarity was not influenced by emotion. In amnesics with hippocampal damage the emotion effect on recollective experience was reduced. Surprisingly, however, these patients still showed a general memory advantage for emotional compared to neutral items, but this effect was manifest primarily as a facilitation of familiarity. The results support the consolidation hypothesis of recollective experience, but suggest that the effects of emotion on episodic memory are not exclusively hippocampally mediated. Rather, emotion may enhance recognition by facilitating familiarity when recollection is impaired due to hippocampal damage.

  10. Treatment of teeth in the esthetic zone in a patient with amelogenesis imperfecta using composite veneers and the clear matrix technique: A case report

    Directory of Open Access Journals (Sweden)

    Bogosavljević Aleksandar

    2016-01-01

    Full Text Available Introduction. Restorative dental treatment of patients with a generalized form of amelogenesis imperfecta (AI remains a challenge even today. The treatment approach is multidisciplinary and includes action of several dental disciplines such as restorative, orthodontic, and prosthetic dental specialties. Case report. A 18-year-old female patent was referred to the Department of Restorative Dentistry and Periodontology at the Military Medical Academy of Belgrade, Serbia. She was diagnosed with AI and formerly had been treated for a long period of time at the Department of Pediatric Dentistry and Orthodontics. Her primary concern upon arrival was discomfort and concern for the esthetic appearance of the anterior teeth. The treatment was done with the modified clear matrix technique used in composite veneer restoration of teeth in the esthetic zone. Conclusion. Because fixed prosthetic restoration with crowns, is the final treatment of AI patients it involves severe tooth structure loss. The clear matrix method which was done in this case allowed for greater comfort, functionality, simplicity, speed, greater economic efficiency and tooth structure preservation.

  11. Sleep-related hippocampo-cortical interplay during emotional memory recollection.

    Directory of Open Access Journals (Sweden)

    Virginie Sterpenich

    2007-10-01

    Full Text Available Emotional events are usually better remembered than neutral ones. This effect is mediated in part by a modulation of the hippocampus by the amygdala. Sleep plays a role in the consolidation of declarative memory. We examined the impact of sleep and lack of sleep on the consolidation of emotional (negative and positive memories at the macroscopic systems level. Using functional MRI (fMRI, we compared the neural correlates of successful recollection by humans of emotional and neutral stimuli, 72 h after encoding, with or without total sleep deprivation during the first post-encoding night. In contrast to recollection of neutral and positive stimuli, which was deteriorated by sleep deprivation, similar recollection levels were achieved for negative stimuli in both groups. Successful recollection of emotional stimuli elicited larger responses in the hippocampus and various cortical areas, including the medial prefrontal cortex, in the sleep group than in the sleep deprived group. This effect was consistent across subjects for negative items but depended linearly on individual memory performance for positive items. In addition, the hippocampus and medial prefrontal cortex were functionally more connected during recollection of either negative or positive than neutral items, and more so in sleeping than in sleep-deprived subjects. In the sleep-deprived group, recollection of negative items elicited larger responses in the amygdala and an occipital area than in the sleep group. In contrast, no such difference in brain responses between groups was associated with recollection of positive stimuli. The results suggest that the emotional significance of memories influences their sleep-dependent systems-level consolidation. The recruitment of hippocampo-neocortical networks during recollection is enhanced after sleep and is hindered by sleep deprivation. After sleep deprivation, recollection of negative, potentially dangerous, memories recruits an alternate

  12. Sleep-related hippocampo-cortical interplay during emotional memory recollection.

    Science.gov (United States)

    Sterpenich, Virginie; Albouy, Geneviève; Boly, Mélanie; Vandewalle, Gilles; Darsaud, Annabelle; Balteau, Evelyne; Dang-Vu, Thien Thanh; Desseilles, Martin; D'Argembeau, Arnaud; Gais, Steffen; Rauchs, Géraldine; Schabus, Manuel; Degueldre, Christian; Luxen, André; Collette, Fabienne; Maquet, Pierre

    2007-10-23

    Emotional events are usually better remembered than neutral ones. This effect is mediated in part by a modulation of the hippocampus by the amygdala. Sleep plays a role in the consolidation of declarative memory. We examined the impact of sleep and lack of sleep on the consolidation of emotional (negative and positive) memories at the macroscopic systems level. Using functional MRI (fMRI), we compared the neural correlates of successful recollection by humans of emotional and neutral stimuli, 72 h after encoding, with or without total sleep deprivation during the first post-encoding night. In contrast to recollection of neutral and positive stimuli, which was deteriorated by sleep deprivation, similar recollection levels were achieved for negative stimuli in both groups. Successful recollection of emotional stimuli elicited larger responses in the hippocampus and various cortical areas, including the medial prefrontal cortex, in the sleep group than in the sleep deprived group. This effect was consistent across subjects for negative items but depended linearly on individual memory performance for positive items. In addition, the hippocampus and medial prefrontal cortex were functionally more connected during recollection of either negative or positive than neutral items, and more so in sleeping than in sleep-deprived subjects. In the sleep-deprived group, recollection of negative items elicited larger responses in the amygdala and an occipital area than in the sleep group. In contrast, no such difference in brain responses between groups was associated with recollection of positive stimuli. The results suggest that the emotional significance of memories influences their sleep-dependent systems-level consolidation. The recruitment of hippocampo-neocortical networks during recollection is enhanced after sleep and is hindered by sleep deprivation. After sleep deprivation, recollection of negative, potentially dangerous, memories recruits an alternate amygdalo

  13. Remembering “The Contract”: Recollections of Bahamians

    Directory of Open Access Journals (Sweden)

    Thompson, Tracey L.

    2012-10-01

    Full Text Available Between 1943 and 1965 an estimated 30,000 Bahamian men and women migrated temporarily to the United States on short-term contracts to work in the agricultural sector. The programme, known as the British West Indies Labor Program, was created to fill labour shortages caused when Americans left the farms to work in more profitable war industries or to serve in the armed forces during World War II. In the Bahamas the programme was sometimes referred to as “The Contract” because each worker signed a contractual agreement to work in the United States. Drawing upon oral histories collected in the early 1990s, this paper uses the recollections of former Contract workers to explore the personal, economic and social ramifications of their experiences working on the Contract.

  14. Recollection and familiarity components of recognition: effect of side of mesio-temporal damage.

    Science.gov (United States)

    Lombardi, Maria Giovanna; Fadda, Lucia; Serra, Laura; Di Paola, Margherita; Caltagirone, Carlo; Carlesimo, Giovanni Augusto

    2016-01-01

    We investigated the memory performance of three patients with unilateral mesio-temporal lobe damage with the aim of evaluating the roles of the left and right hemispheres in recollection and familiarity. Consistent with the "Material Specificity Hypothesis", the right brain-damaged individual was selectively poor on recollection and familiarity tests for faces. Conversely, left-lesioned patients were severely deficient in recollection and familiarity of verbal material but mildly deficient on visual-spatial tests. This partially unexpected finding is interpreted in light of the ability of humans to verbally recode almost any material, thus giving rise to left-hemisphere effects for nominally nonverbal stimuli.

  15. One cases report:adult clear cell sarcoma of kidney%成人肾透明细胞肉瘤1例病例报道

    Institute of Scientific and Technical Information of China (English)

    江冬梅; 王凤玮

    2015-01-01

    Clear cell sarcoma of kidney(CCSK) is a rare and malignant sarcoma, whose the origin of organization is not clear,and most reports indicated the patients is children,but not adults.The sarcoma has hard prognosis and poor sur-vival rate.CCSK is similar to other renal malignant tumors very much in clinical and histological aspects,therefore,the differential diagnosis with other renal malignant tumor is very important.Now we report a case of an adult female pa-tients who was already diagnosed with CCSK of the kidney,and state the discrimination with CCSK of kidney and Wilms’tumor.%肾透明细胞肉瘤(CCSK)是一种组织来源尚未十分清楚的罕见软组织恶性肿瘤,该病多见于儿童,成人患者罕见。成人CCSK预后极差,生存期短。 CCSK临床表现和组织形态学与多种肾恶性肿瘤相似,误诊率较高,在患者预后和治疗方面,CCSK与其他肾恶性肿瘤差别较大,因此,CCSK与其他肾恶性肿瘤的鉴别诊断对于CCSK的确诊至关重要。本文报道我院1例已确诊为CCSK的成年女性患者,简要阐述该疾病与肾透明细胞癌、肾母细胞瘤的鉴别。

  16. Collision tumor of the kidney composed of clear cell carcinoma and collecting duct carcinoma:report of a case with unusual morphology and clinical follow-up

    Institute of Scientific and Technical Information of China (English)

    Rhonda Burch-Smith; Nizar M Tannir; Erika Resetkova; Pheroze Tamboli; Priya Rao

    2014-01-01

    We report the case of a 67-year-old female who presented with a large renal mass. Gross examination of the nephrectomy specimen demonstrated a 6-cm renal mass that invaded into the renal sinus and perinephric fat. Histologic examination revealed two distinct tumor types. The first type was a conventional (clear cell) renal cell carcinoma that was of low nuclear grade and comprised the minority of the overall tumor. The second type was a high-grade collecting duct carcinoma with glandular/tubular differentiation and composed the majority of the tumor. Immunohistochemical studies demonstrated distinctive patterns of the two tumor types, thus confirming two distinct lineages. Five months postoperatively, the patient developed metastasis to the lungs and right hilar lymph node region. A fine needle aspiration of a lung nodule demonstrated a metastatic, poorly differentiated carcinoma, similar to the colecting duct carcinoma component in the kidney. Colision tumors of the kidney are rare with fewer than 10 cases reported in the literature. Our report further expands the spectrum of this rare phenomenon.

  17. Tobacco company efforts to influence the Food and Drug Administration-commissioned Institute of Medicine report clearing the smoke: an analysis of documents released through litigation.

    Directory of Open Access Journals (Sweden)

    Crystal E Tan

    Full Text Available BACKGROUND: Spurred by the creation of potential modified risk tobacco products, the US Food and Drug Administration (FDA commissioned the Institute of Medicine (IOM to assess the science base for tobacco "harm reduction," leading to the 2001 IOM report Clearing the Smoke. The objective of this study was to determine how the tobacco industry organized to try to influence the IOM committee that prepared the report. METHODS AND FINDINGS: We analyzed previously secret tobacco industry documents in the University of California, San Francisco Legacy Tobacco Documents Library, and IOM public access files. (A limitation of this method includes the fact that the tobacco companies have withheld some possibly relevant documents. Tobacco companies considered the IOM report to have high-stakes regulatory implications. They developed and implemented strategies with consulting and legal firms to access the IOM proceedings. When the IOM study staff invited the companies to provide information on exposure and disease markers, clinical trial design for safety and efficacy, and implications for initiation and cessation, tobacco company lawyers, consultants, and in-house regulatory staff shaped presentations from company scientists. Although the available evidence does not permit drawing cause-and-effect conclusions, and the IOM may have come to the same conclusions without the influence of the tobacco industry, the companies were pleased with the final report, particularly the recommendations for a tiered claims system (with separate tiers for exposure and risk, which they believed would ease the process of qualifying for a claim and license to sell products comparable to existing conventional cigarettes ("substantial equivalence" without prior regulatory approval. Some principles from the IOM report, including elements of the substantial equivalence recommendation, appear in the 2009 Family Smoking Prevention and Tobacco Control Act. CONCLUSIONS: Tobacco

  18. Algorithms for Recollection of Search Terms Based on the Wikipedia Category Structure

    Directory of Open Access Journals (Sweden)

    Stijn Vandamme

    2014-01-01

    Full Text Available The common user interface for a search engine consists of a text field where the user can enter queries consisting of one or more keywords. Keyword query based search engines work well when the users have a clear vision what they are looking for and are capable of articulating their query using the same terms as indexed. For our multimedia database containing 202,868 items with text descriptions, we supplement such a search engine with a category-based interface whose category structure is tailored to the content of the database. This facilitates browsing and offers the users the possibility to look for named entities, even if they forgot their names. We demonstrate that this approach allows users who fail to recollect the name of named entities to retrieve data with little effort. In all our experiments, it takes 1 query on a category and on average 2.49 clicks, compared to 5.68 queries on the database’s traditional text search engine for a 68.3% success probability or 6.01 queries when the user also turns to Google, for a 97.1% success probability.

  19. Is there a recognition memory deficit in Parkinson's disease? Evidence from estimates of recollection and familiarity.

    Science.gov (United States)

    Weiermann, Brigitte; Stephan, Marianne A; Kaelin-Lang, Alain; Meier, Beat

    2010-03-01

    There is conflicting evidence whether Parkinson's disease (PD) is associated with impaired recognition memory and which of its underlying processes, namely recollection and familiarity, is more affected by the disease. The present study explored the contribution of recollection and familiarity to verbal recognition memory performance in 14 nondemented PD patients and a healthy control group with two different methods: (i) the word-frequency mirror effect, and (ii) Remember/Know judgments. Overall, recognition memory of patients was intact. The word-frequency mirror effect was observed both in patients and controls: Hit rates were higher and false alarm rates were lower for low-frequency compared to high-frequency words. However, Remember/Know judgments indicated normal recollection, but impaired familiarity. Our findings suggest that mild to moderate PD patients are selectively impaired at familiarity whereas recollection and overall recognition memory are intact.

  20. Out-of-season recollection of drug use for seasonal IgE-mediated rhinitis

    DEFF Research Database (Denmark)

    Bodtger, Uffe; Malling, Hans-Jørgen; Poulsen, Lars K.

    2005-01-01

    The history of seasonal, IgE-mediated (allergic) rhinitis is often obtained postseasonally as a retrospective assessment. It is not known whether recollected drug use is representative for the in-seasonal medication history....

  1. The role of the human hippocampus in familiarity-based and recollection-based recognition memory.

    Science.gov (United States)

    Wixted, John T; Squire, Larry R

    2010-12-31

    The ability to recognize a previously encountered stimulus is dependent on the structures of the medial temporal lobe and is thought to be supported by two processes, recollection and familiarity. A focus of research in recent years concerns the extent to which these two processes depend on the hippocampus and on the other structures of the medial temporal lobe. One view holds that the hippocampus is important for both processes, whereas a different view holds that the hippocampus supports only the recollection process and the perirhinal cortex supports the familiarity process. One approach has been to study patients with hippocampal lesions and to contrast old/new recognition (which can be supported by familiarity) to free recall (which is supported by recollection). Despite some early case studies suggesting otherwise, several group studies have now shown that hippocampal patients exhibit comparable impairments on old/new recognition and free recall. These findings suggest that the hippocampus is important for both recollection and familiarity. Neuroimaging studies and Receiver Operating Characteristic analyses also initially suggested that the hippocampus was specialized for recollection, but these studies involved a strength confound (strong memories have been compared to weak memories). When steps are taken to compare strong recollection-based memories with strong familiarity-based memories, or otherwise control for memory strength, evidence for a familiarity signal (as well as a recollection signal) is evident in the hippocampus. These findings suggest that the functional organization of the medial temporal lobe is probably best understood in terms unrelated to the distinction between recollection and familiarity.

  2. Compressed Recollection As a Constituent of “Talk” As a Hypergenre

    Directory of Open Access Journals (Sweden)

    Olga Petrovna Kormazina

    2015-11-01

    Full Text Available The article is devoted to the speech genre "recollection" that is described as a constituent of the hypergenre "talk"; the last is viewed by the author as a complex genre unity associated with natural communication. It is a tradition in linguistics while describing the recollection to point to its typological features – narrative character, which presupposes long retention of initiative by one speaker and, consequently, the great extension of replicas. The author singles out the "compressed recollection" and defines it as a short ascertaining message about some fact of the past, which might be deployed into a complete narrative. The transcribed records of Primorsky Region inhabitants' live speech in situations of family and companion communication made the material for this research; in particular, talks of 20 informants aged from 11 to 85 were recorded in 2013-2015. The compressed recollection is characterized in three aspects. A semantic aspect indicates to its main proposition types: proposition of event, proposition of object, ascertaining proposition. A communicative-pragmatic aspect uncovers its main functions: illustration of the author's words, appeal to the collocutor's memory, introduction of a new thematic fragment, introduction of a new sub-theme including. A structuralillocutionary aspect focuses on the compressed recollection as initial and reaction replicas in the dialogue. The set of diverse features verifies the notion of compressed recollection as a constituent of the hypergenre "talk".

  3. Working (And Sparring) With Luis: Some Personal Recollections

    Science.gov (United States)

    Pripstein, Moishe

    2011-04-01

    Luis Alvarez was the most remarkable physicist I have ever worked with. As a member of his bubble chamber group at the Lawrence Radiation Laboratory in Berkeley and subsequently as a leader of that group for several years, I could appreciate his outstanding attributes as a physicist and his forceful and colorful personality. Each day at the lab seemed exciting. Although he created the largest research group in particle physics in the world at the time, Luis was an ardent foe of group-think, which he characterized as ``intellectual phase-lock''. He had an uncanny intuition about physics and technology, coupled with an insatiable curiosity about the world around him. He is justly renowned as a member of the Inventors Hall of Fame for his myriad inventions and as a Nobel Laureate in physics for his contributions to particle physics through his development of the hydrogen bubble chamber technique, leading to the discovery of a large number of resonance states. However, it was his wide-ranging curiosity which led him to one of his finest achievements, while working with his son Walter - developing the asteroid impact theory as the explanation of the extinction of the dinosaurs. I will offer some personal recollections of Luis and the group in this period, including some of his other intriguing efforts which illustrate the breadth of his interests, pertaining to the Kennedy assassination and x-raying the pyramids, among them. All in all, a brilliant and most unusual scientist and stimulating colleague.

  4. Spectrally tunable magnetic nanoparticles designed for distribution/recollection applications

    Science.gov (United States)

    McDowall, Nicholas B.; Wilkins, James R.; Carroll, Kyler J.; Edwards, Jarrod D.; Nelson, Jean D.; Carpenter, Everett E.; Glaspell, Garry P.

    2010-05-01

    The comprehensive goal of this research is the synthesis and characterization of nanomaterials that are spectrally tunable in terms of their electromagnetic signal, are robust, magnetic (allowing their piloted movement), and have the potential to be functionalized for the detection of CBRNE threats. Various chemical methods were utilized for synthesis of magnetic (iron) and luminescent rare earth (RE) components, and their mixtures. Effects of integrating an iron core into RE luminescent lattices (excited by UV, emit in the VIS) were investigated. The determination of the optimum balances between magnetic and luminescent components such that the magnetism was maximized while maintaining acceptable fluorescence integrity will be discussed. The emphasis of this work is focused on developing a distributed sensor suitable for use in the terrestrial environment. The robust properties of using a RE luminescent shell would allow the particles to be resistant to photobleaching. Additionally the chemical stability of the RE shell would allow operation in a variety of pH conditions. The magnetic core will ultimately allow the distributed particles to be recollected.

  5. Neurophysiological evidence for a recollection impairment in amnesia patients that leaves familiarity intact.

    Science.gov (United States)

    Addante, Richard James; Ranganath, Charan; Olichney, John; Yonelinas, Andrew P

    2012-11-01

    In several previous behavioral studies, we have identified a group of amnestic patients that, behaviorally, appear to exhibit severe deficits in recollection with relative preservation of familiarity-based recognition. However, these studies have relied exclusively on behavioral measures, rather than direct measures of physiology. Event-related potentials (ERPs) have been used to identify putative neural correlates of familiarity- and recollection-based recognition memory, but little work has been done to determine the extent to which these ERP correlates are spared in patients with relatively specific memory disorders. ERP studies of recognition in healthy subjects have indicated that recollection and familiarity are related to a parietal old-new effect characterized as a late positive component (LPC) and an earlier mid-frontal old-new effect referred to as an 'FN400', respectively. Here, we sought to determine the extent to which the putative ERP correlates of recollection and familiarity are intact or impaired in these patients. We recorded ERPs in three amnestic patients and six age matched controls while they made item recognition and source recognition judgments. The current patients were able to discriminate between old and new items fairly well, but showed nearly chance-level performance at source recognition. Moreover, whereas control subjects exhibited ERP correlates of memory that have been linked to recollection and familiarity, the patients only exhibited the mid-frontal FN400 ERP effect related to familiarity-based recognition. The results show that recollection can be severely impaired in amnesia even when familiarity-related processing is relatively spared, and they also provide further evidence that ERPs can be used to distinguish between neural correlates of familiarity and recollection.

  6. Clear cell chondrosarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, R.; David, R.; Cierney, G. III

    1985-01-01

    The clinical, radiologic, and histopathologic features of three cases of clear cell chondrosarcoma are described. On radiographs, this rather benign-appearing tumor resembles a chondroblastoma when it occurs at the end of a long bone, and may occasionally show a calcified matrix. However, it has distinctive tumor cells with a centrally placed vesicular nucleus surrounded by clear cytoplasm. The lesion has a low-grade malignancy and is amenable to en bloc surgical resection, which results in a much better prognosis than that of conventional chondrosarcoma.

  7. Snow-clearing operations

    CERN Multimedia

    EN Department

    2010-01-01

    To facilitate snow clearing operations, which commence at 4.30 in the morning, all drivers of CERN cars are kindly requested to park them together in groups. This will help us greatly assist us in our work. Thank-you for your help. Transport Group / EN-HE Tel. 72202

  8. Recollection, not familiarity, decreases in healthy ageing: Converging evidence from four estimation methods.

    Science.gov (United States)

    Koen, Joshua D; Yonelinas, Andrew P

    2016-01-01

    Although it is generally accepted that ageing is associated with recollection impairments, there is considerable disagreement surrounding how healthy ageing influences familiarity-based recognition. One factor that might contribute to the mixed findings regarding age differences in familiarity is the estimation method used to quantify the two mnemonic processes. Here, this issue is examined by having a group of older adults (N = 39) between 40 and 81 years of age complete remember/know (RK), receiver-operating characteristic (ROC) and process dissociation (PD) recognition tests. Estimates of recollection, but not familiarity, showed a significant negative correlation with chronological age. Inconsistent with previous findings, the estimation method did not moderate the relationship between age and estimates of recollection and familiarity. In a final analysis, recollection and familiarity were estimated as latent factors in a confirmatory factor analysis that modelled the covariance between measures of free recall and recognition, and the results converged with the results from the RK, PD and ROC tasks. These results are consistent with the hypothesis that episodic memory declines in older adults are primary driven by recollection deficits, and also suggest that the estimation method plays little to no role in age-related decreases in familiarity.

  9. Recollection is a continuous process: Evidence from plurality memory receiver operating characteristics.

    Science.gov (United States)

    Slotnick, Scott D; Jeye, Brittany M; Dodson, Chad S

    2016-01-01

    Is recollection a continuous/graded process or a threshold/all-or-none process? Receiver operating characteristic (ROC) analysis can answer this question as the continuous model and the threshold model predict curved and linear recollection ROCs, respectively. As memory for plurality, an item's previous singular or plural form, is assumed to rely on recollection, the nature of recollection can be investigated by evaluating plurality memory ROCs. The present study consisted of four experiments. During encoding, words (singular or plural) or objects (single/singular or duplicate/plural) were presented. During retrieval, old items with the same plurality or different plurality were presented. For each item, participants made a confidence rating ranging from "very sure old", which was correct for same plurality items, to "very sure new", which was correct for different plurality items. Each plurality memory ROC was the proportion of same versus different plurality items classified as "old" (i.e., hits versus false alarms). Chi-squared analysis revealed that all of the plurality memory ROCs were adequately fit by the continuous unequal variance model, whereas none of the ROCs were adequately fit by the two-high threshold model. These plurality memory ROC results indicate recollection is a continuous process, which complements previous source memory and associative memory ROC findings.

  10. Total Quality Management in Higher Education: Clearing the Hurdles. A Survey on Strategies for Implementing Quality Management Practices in Higher Education. A GOAL/QPC Application Report.

    Science.gov (United States)

    Seymour, Daniel

    Based on a survey of Quality Management (QM) practitioners at 21 colleges, this study presents the 10 most difficult implementation hurdles to QM in higher education and a set of hurdle-clearing strategies. The hurdles are: (1) lack of time to implement QM; (2) perception that QM is something for janitorial and housing staffs but not applicable to…

  11. Total Quality Management in Higher Education: Clearing the Hurdles. A Survey on Strategies for Implementing Quality Management Practices in Higher Education. A GOAL/QPC Application Report.

    Science.gov (United States)

    Seymour, Daniel

    Based on a survey of Quality Management (QM) practitioners at 21 colleges, this study presents the 10 most difficult implementation hurdles to QM in higher education and a set of hurdle-clearing strategies. The hurdles are: (1) lack of time to implement QM; (2) perception that QM is something for janitorial and housing staffs but not applicable to…

  12. Preliminary report on mercury geochemistry of placer gold dredge tailings, sediments, bedrock, and waters in the Clear Creek restoration area, Shasta County, California

    Science.gov (United States)

    Ashley, Roger P.; Rytuba, James J.; Rogers, Ronald; Kotlyar, Boris B.; Lawler, David

    2002-01-01

    Clear Creek, one of the major tributaries of the upper Sacramento River, drains the eastern Trinity Mountains. Alluvial plain and terrace gravels of lower Clear Creek, at the northwest edge of the Sacramento Valley, contain placer gold that has been mined since the Gold Rush by various methods including dredging. In addition, from the 1950s to the 1980s aggregate-mining operations removed gravel from the lower Clear Creek flood plain. Since Clear Creek is an important stream for salmon production, a habitat restoration program is underway to repair damage from mining and improve conditions for spawning. This program includes using dredge tailings to fill in gravel pits in the flood plain, raising the concern that mercury lost to these tailings in the gold recovery process may be released and become available to biota. The purposes of our study are to determine concentrations and speciation of mercury in sediments, tailings, and water in the lower Clear Creek area, and to determine its mobility. Mercury concentrations in bedrock and unmined gravels both within and above the mined area are low, and are taken to represent background concentrations. Bulk mercury values in flood-plain sediments and dry tailings are elevated to several times these background concentrations. Mercury in sediments and tailings is associated with fine size fractions. Although methylmercury levels are generally low in sediments, shallow ponds in the flood plain may have above-normal methylation potential. Stream waters in the area show low mercury and methylmercury levels. Ponds with elevated methylmercury in sediments have more methylmercury in their waters as well. One seep in the area is highly saline, and enriched in mercury, lithium, and boron, similar to connate waters that are expelled along thrust faults to the south on the west side of the Sacramento Valley. This occurrence suggests that mercury in waters may at least in part be from sources other than placer mining.

  13. [Influence of survival processing and delay on recollection and familiarity in recognition].

    Science.gov (United States)

    Munetsugu, Tetsuya; Horiuchi, Takashi

    2015-08-01

    The survival processing effect is a robust memory phenomenon of memory whereby encouraging participants to judge words for relevance to a survival situation produces better recall than other processing tasks such as semantic or self-reference tasks (Nairne, Thompson, & Pandeirada, 2007). The present study separated memory performance into recollection and familiarity, and estimated the contribution of these two factors to the survival processing effect as adaptive memory by using a recognition test based on the dual-process signal detection model. This study also examined the long-term persistence of the effect by delay manipulation (immediate, after a week, after five weeks) of the recognition test. Under delayed conditions (after a week and five weeks), survival processing advantage occurred on recollection, but semantic processing had no effect. In contrast, for familiarity, there was no significant difference between survival and semantic processing. These findings suggest that the survival processing effect mainly relies on recollection.

  14. Mercury Geochemistry of Gold Placer Tailings, Sediments, Bedrock, and Waters in the Lower Clear Creek Area, Shasta County, California - Report of Investigations, 2001-2003

    Science.gov (United States)

    Ashley, Roger P.; Rytuba, James J.

    2008-01-01

    Clear Creek, one of the major tributaries of the upper Sacramento River, drains the eastern Trinity Mountains. Alluvial plain and terrace gravels of lower Clear Creek, at the northwest edge of the Sacramento Valley, contain placer gold that has been mined since the Gold Rush by various methods including hydraulic mining and dredging. In addition, from the 1950s to the 1980s aggregate-mining operations removed gravel from the lower Clear Creek flood plain. Since Clear Creek is an important stream for salmon production, a habitat restoration program is underway to repair damage from mining and improve conditions for spawning. This program includes moving dredge tailings to increase the area of spawning gravel and to fill gravel pits in the flood plain, raising the concern that mercury lost to these tailings in the gold recovery process may be released and become available to biota. The purposes of our study are to identify sources, transport, and dispersal of mercury in the lower Clear Creek area and identify environments in which bioavailable methylmercury is produced. Analytical data acquired include total mercury and methylmercury concentrations in sediments, tailings, and water. Mercury concentrations in bedrock and unmined gravels in and around the mined area are low and are taken to represent background concentrations. Bulk mercury values in placer mining tailings range from near-background in coarse dry materials to more than 40 times background in sands and silts exposed to mercury in sluices. Tailings are entrained in flood-plain sediments and active stream sediments; consequently, mercury concentrations in these materials range from background to about two to three times background. Mercury in sediments and tailings is associated with fine size fractions. The source of most of this mercury is historical gold mining in the Clear Creek watershed. Although methylmercury levels are low in most of these tailings and sediments, flood-plain sediment in shallow

  15. The Development of Recollection and Familiarity in Childhood and Adolescence: Evidence from the Dual-Process Signal Detection Model

    Science.gov (United States)

    Ghetti, Simona; Angelini, Laura

    2008-01-01

    Two experiments examined the development of recollection (recalling qualitative details about an event) and familiarity (recognizing the event) using the dual-process signal detection model. In Experiment 1 (n = 117; ages 6, 8, 10, 14, and 18 years), recollection improved from childhood to adolescence after semantic encoding but not after…

  16. Age-related changes in neural activity associated with familiarity, recollection and false recognition.

    Science.gov (United States)

    Duarte, Audrey; Graham, Kim S; Henson, Richard N

    2010-10-01

    Older adults often exhibit elevated false recognition for events that never occurred, while simultaneously experiencing difficulty in recognizing events that actually occurred. It has been proposed that reduced recollection in conjunction with an over-reliance on familiarity may contribute to this pattern of results. This explanation is somewhat inconsistent, however, with recent evidence suggesting that familiarity and associated neural activity are reduced in healthy aging. Alternatively, given that illusory memory may be based, in part, on veridical memory processes (recollection/familiarity), one might predict that older adults exhibit enhanced false alarm rates because the neural signatures associated with true recognition (hits) and false recognition (false alarms) are less distinguishable in old than in young adults. Here, we used event-related fMRI to measure the effects of aging on neural activity associated with recollection, familiarity and familiarity-based false alarms for objects in young and older adults. Compared to young adults, older adults exhibited elevated false alarm rates and impaired behavioral indices of recollection and familiarity. Imaging data showed that older adults exhibited reduced recollection effects in the left parietoccipital cortex. Furthermore, while similar regions in frontal, parietal, lateral and inferior temporal cortices contributed to familiarity-based true and false recognition, reduced familiarity-related activity in frontal and inferior temporal regions in the older adults resulted in decreased differentiation between true and false recognition effects in this group. Our results suggest that reductions in neural activity associated with both recollection and familiarity for studied items may contribute to elevated false recognition in older adults, via reduced differentiation between the neural activity associated with true and false memory.

  17. Differential effects of stress-induced cortisol responses on recollection and familiarity-based recognition memory.

    Science.gov (United States)

    McCullough, Andrew M; Ritchey, Maureen; Ranganath, Charan; Yonelinas, Andrew

    2015-09-01

    Stress-induced changes in cortisol can impact memory in various ways. However, the precise relationship between cortisol and recognition memory is still poorly understood. For instance, there is reason to believe that stress could differentially affect recollection-based memory, which depends on the hippocampus, and familiarity-based recognition, which can be supported by neocortical areas alone. Accordingly, in the current study we examined the effects of stress-related changes in cortisol on the processes underlying recognition memory. Stress was induced with a cold-pressor test after incidental encoding of emotional and neutral pictures, and recollection and familiarity-based recognition memory were measured one day later. The relationship between stress-induced cortisol responses and recollection was non-monotonic, such that subjects with moderate stress-related increases in cortisol had the highest levels of recollection. In contrast, stress-related cortisol responses were linearly related to increases in familiarity. In addition, measures of cortisol taken at the onset of the experiment showed that individuals with higher levels of pre-learning cortisol had lower levels of both recollection and familiarity. The results are consistent with the proposition that hippocampal-dependent memory processes such as recollection function optimally under moderate levels of stress, whereas more cortically-based processes such as familiarity are enhanced even with higher levels of stress. These results indicate that whether post-encoding stress improves or disrupts recognition memory depends on the specific memory process examined as well as the magnitude of the stress-induced cortisol response.

  18. Biological and Physical Inventory of Clear Creek, Orofino Creek, and the Potlatch River, Tributary Streams of the Clearwater River, Idaho, 1984 Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, David B.

    1985-05-01

    Clear Creek, Orofino Creek, and Potlatch Creek, three of the largest tributaries of the lower Clearwater River Basin, were inventoried during 1984. The purpose of the inventory was to identify where anadromous salmonid production occurs and to recommend enhancement alternatives to increase anadromous salmonid habitat in these streams. Anadromous and fluvial salmonids were found in all three drainages. The lower reach of Clear Creek supported a low population of rainbow-steelhead, while the middle reach supported a much greater population of rainbow-steelhead. Substantial populations of cutthroat trout were also found in the headwaters of Clear Creek. Rainbow-steelhead and brook trout were found throughout Orofino Creek. A predominant population of brook trout was found in the headwaters while a predominant population of rainbow-steelhead was found in the mainstem and lower tributaries of Orofino Creek. Rainbow-steelhead and brook trout were also found in the Potlatch River. Generally, the greatest anadromous salmonid populations in the Potlatch River were found within the middle reach of this system. Several problems were identified which would limit anadromous salmonid production within each drainage. Problems affecting Clear Creek were extreme flows, high summer water temperature, lack of riparian habitat, and high sediment load. Gradient barriers prevented anadromous salmonid passage into Orofino Creek and they are the main deterrent to salmonid production in this system. Potlatch River has extreme flows, high summer water temperature, a lack of riparian habitat and high sediment loads. Providing passage over Orofino Falls is recommended and should be considered a priority for improving salmonid production in the lower Clearwater River Basin. Augmenting flows in the Potlatch River is also recommended as an enhancement measure for increasing salmonid production in the lower Clearwater River Basin. 18 refs., 5 figs., 85 tabs.

  19. Clearing the Big Smog

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Beijing is trying to clean up its sky with a new standard for vehicle emissions From March 1,Beijing has imple- mented a new stricter vehicle emission standard that could lead to cleaner air,but also force thousands of cars off the road. StandardⅣ,the latest in a series of measures aimed at clearing the per- sistent smog,will match the current standard of the European Union. All the new light petro vehicles that are on sale in the Beijing market shall

  20. The Cult of 'Krazy Kat': Memory and Recollection in the Age of Mechanical Reproduction

    Directory of Open Access Journals (Sweden)

    Aaron Humphrey

    2017-06-01

    Full Text Available George Herriman’s comic strip 'Krazy Kat' has been discussed in mythic terms for more than half a century. This article argues that much of this ‘mythology’ has not been founded on the material itself, but rather on memories and recollections of readers and critics. Using Walter Benjamin’s notions of cult value and exhibition value, this article investigates the historical circumstances that shaped the most prominent of these recollections to show how writers like Gilbert Seldes and E. E. Cummings shaped the myth of 'Krazy Kat' to create an ‘aura’ of genius around a work that was largely inaccessible to most readers.

  1. Episodic feeling-of-knowing relies on noncriterial recollection and familiarity: Evidence using an online remember-know procedure.

    Science.gov (United States)

    Isingrini, Michel; Sacher, Mathilde; Perrotin, Audrey; Taconnat, Laurence; Souchay, Céline; Stoehr, Hélène; Bouazzaoui, Badiâa

    2016-04-01

    We examined the hypothesis that feeling-of-knowing judgments rely on recollection as well as on familiarity prompted by the cue presentation. A remember-know-no memory procedure was combined with the episodic FOK procedure employing a cue-target pair memory task. The magnitude of FOK judgments and FOK accuracy were examined as a function of recollection, familiarity, or the "no memory" option. Results showed that the proportion of R and K responses was similar. FOK accuracy and magnitude of FOK judgments were higher for R and K responses than for N responses. FOK accuracy related to R and K responses were above chance level, but FOK was not accurate in the "no memory" condition. Finally, both FOK magnitude and FOK accuracy were related more to recollection than to familiarity. These results support the hypothesis that both recollection and familiarity are determinants of the FOK process, although they suggest that recollection has a stronger influence.

  2. Narrative report: Klamath Basin National Wildlife Refuges: Tule Lake, Lower Klamath, and Clear Lake in California, Upper Klamath and Klamath Forest in Oregon: January - April, 1962

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1962. The report begins by summarizing the...

  3. Narrative report: Klamath Basin National Wildlife Refuges: Tule Lake, Lower Klamath, and Clear Lake in California, Upper Klamath and Klamath Forest in Oregon: January - April, 1963

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1963. The report begins by summarizing the...

  4. Narrative report: January - April, 1961: Tule Lake, Lower Klamath, Clear Lake, Upper Klamath, and Klamath Forest National Wildlife Refuges, California and Oregon

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from January through April of 1961. The report begins by summarizing the...

  5. Narrative report: Klamath Basin National Wildlife Refuges: Tule Lake, Lower Klamath, and Clear Lake in California, Upper Klamath and Klamath Forest in Oregon: September - December, 1962

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from September through December of 1962. The report begins by...

  6. Narrative report: May - August, 1961: Tule Lake, Lower Klamath, Clear Lake, Upper Klamath and Klamath Forest National Wildlife Refuges, California and Oregon

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1961. The report begins by summarizing the...

  7. Klamath Basin National Wildlife Refuges: Tule Lake, Lower Klamath, Clear Lake, Upper Klamath, Klamath Forest, and Bear Valley National Wildlife Refuges: Annual narrative report: Calendar year 1987

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Klamath Basin NWRs outlines Refuge accomplishments during the 1987 calendar year. The report begins with a summary of the year's...

  8. Narrative report: Klamath Basin National Wildlife Refuges: Tule Lake*, Lower Klamath*, and Clear Lake* in California, Upper Klamath* and Klamath Forest* in Oregon: 1971

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments during the 1971 calendar year. The report begins by summarizing the...

  9. Narrative report: Klamath Basin National Wildlife Refuges: Tule Lake*, Lower Klamath*, and Clear Lake* in California, Upper Klamath* and Klamath Forest* in Oregon: 1969

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments during the 1969 calendar year. The report begins by summarizing the...

  10. Klamath Basin National Wildlife Refuges: Tule Lake, Lower Klamath, Clear Lake, Upper Klamath, Klamath Forest, and Bear Valley National Wildlife Refuges: Annual narrative report: Calendar year 1980

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Klamath Basin National Wildlife Refuges outlines Refuge accomplishments during the 1980 calendar year. The report begins with an...

  11. Narrative report of the Tule Lake, Lower Klamath, Upper Klamath, and Clear Lake National Wildlife Refuges: Period of May 1 to August 31, 1948

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments from May through August of 1948. The report begins by summarizing the...

  12. Klamath Basin National Wildlife Refuges: Tule Lake, Lower Klamath, Clear Lake, Upper Klamath, Klamath Forest, and Bear Valley National Wildlife Refuges: Annual narrative report: Calendar year 1983

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Klamath Basin NWRs outlines Refuge accomplishments during the 1983 calendar year. The report begins with a summary of the year's...

  13. Klamath Basin National Wildlife Refuges: Tule Lake, Lower Klamath, Clear Lake, Upper Klamath, and Klamath Forest National Wildlife Refuges: Annual narrative report: Calendar year 1978

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Klamath Basin National Wildlife Refuges outlines Refuge accomplishments during the 1978 calendar year. The report begins with an...

  14. Klamath Basin National Wildlife Refuges: Tule Lake, Lower Klamath, Clear Lake, Upper Klamath, and Klamath Forest National Wildlife Refuges: Annual narrative report: Calendar year 1977

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Klamath Basin National Wildlife Refuges outlines Refuge accomplishments during the 1977 calendar year. The report begins with an...

  15. Narrative report: Klamath Basin National Wildlife Refuges: Tule Lake, Lower Klamath, and Clear Lake in California, Upper Klamath and Klamath Forest in Oregon: 1965

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Tule Lake National Wildlife Refuge outlines Refuge accomplishments during the 1965 calendar year. The report begins by summarizing the...

  16. Clear cell carcinoma derived from an endometriosis focus in a scar after a caesarean section--a case report and literature review.

    Science.gov (United States)

    Dobrosz, Zuzanna; Paleń, Piotr; Stojko, Rafał; Właszczuk, Paweł; Niesłuchowska-Hoxha, Anna; Piechuta-Kośmider, Ilona

    2014-10-01

    Endometriosis is defined as the occurrence of endometrial glands and endometrial stromal cells outside their typical localization within the uterus. Malignant transformation of endometriosis foci in a scar after a caesarean section (cc) is very rare--until 2013 (in a span of 40 years), about 40 such cases have been described. In our article, we describe a case of a 42-year-old woman with a tumour localized in a scar after a caesarean section. The tumour was diagnosed as clear cell carcinoma derived from an endometriosis focus. The long time interval--17 years in average (from 3 to 39 years) between the surgery (cesarean section in most cases) and the tumor diagnosis is characteristic. In the case we describe, the patient was diagnosed 16 years after the endometriosis focus in the scar had arised. Even though endometriosis is a benign lesion, it has many features distinctive for invasive carcinoma; it may itself undergo a malignant transformation as well as increase the risk of endometrial carcinoma or clear cell ovarian carcinoma. Maybe in future, more exhaustive studies will allow establishing a therapeutic protocol in patients with extra-ovarian malignant transformation of endometriosis foci.

  17. Perceived recollection of frequent exposure to foods in childhood is associated with adulthood liking.

    Science.gov (United States)

    Wadhera, Devina; Capaldi Phillips, Elizabeth D; Wilkie, Lynn M; Boggess, May M

    2015-06-01

    Food preferences and habits learned at a young age can influence adulthood dietary patterns and weight, but the mechanism remains to be elucidated. We investigated the effect of perceived recollections of early food experiences on current liking for those foods by 670 college students. We showed that the perceived recollection of frequent consumption of foods in childhood was significantly related to current liking for the vast majority of the foods, including nutritious foods such as vegetables. Similarly, parental encouragement and modeling was positively related with current liking, even for foods that were disliked in childhood. Additionally, perceived recollections of parental restriction or forced consumption were significantly negatively related with current liking. Lastly, we demonstrated that perceived recollections by college students of childhood eating practices were in moderate agreement with those of their parents, lending credibility to the retrospective survey methodology in determining long-term effects of exposure on current food habits. These findings show that the perceived recalled frequency of consumption of foods is one determinant of the food preferences of adults, demonstrating a long-term effect of frequency of exposure, a finding consistent with experimentally controlled short-term studies. Frequent exposure to foods in childhood could be a simple and effective way for parents and caregivers to instill healthy eating habits in children.

  18. Individual differences in forced-choice recognition memory: partitioning contributions of recollection and familiarity.

    Science.gov (United States)

    Migo, Ellen M; Quamme, Joel R; Holmes, Selina; Bendell, Andrew; Norman, Kenneth A; Mayes, Andrew R; Montaldi, Daniela

    2014-01-01

    In forced-choice recognition memory, two different testing formats are possible under conditions of high target-foil similarity: Each target can be presented alongside foils similar to itself (forced-choice corresponding; FCC), or alongside foils similar to other targets (forced-choice noncorresponding; FCNC). Recent behavioural and neuropsychological studies suggest that FCC performance can be supported by familiarity whereas FCNC performance is supported primarily by recollection. In this paper, we corroborate this finding from an individual differences perspective. A group of older adults were given a test of FCC and FCNC recognition for object pictures, as well as standardized tests of recall, recognition, and IQ. Recall measures were found to predict FCNC, but not FCC performance, consistent with a critical role for recollection in FCNC only. After the common influence of recall was removed, standardized tests of recognition predicted FCC, but not FCNC performance. This is consistent with a contribution of only familiarity in FCC. Simulations show that a two-process model, where familiarity and recollection make separate contributions to recognition, is 10 times more likely to give these results than a single-process model. This evidence highlights the importance of recognition memory test design when examining the involvement of recollection and familiarity.

  19. Information presentation format moderates the unconscious-thought effect: The role of recollection.

    Science.gov (United States)

    Abadie, Marlène; Waroquier, Laurent; Terrier, Patrice

    2016-09-01

    The unconscious-thought effect occurs when distraction improves complex decision-making. In two experiments using the unconscious-thought paradigm, we investigated the effect of presentation format of decision information (i) on memory for decision-relevant information and (ii) on the quality of decisions made after distraction, conscious deliberation or immediately. We used the process-dissociation procedure to measure recollection and familiarity. The two studies showed that presenting information blocked per criterion led participants to recollect more decision-relevant details compared to a presentation by option. Moreover, a Bayesian meta-analysis of the two studies provided strong evidence that conscious deliberation resulted in better decisions when the information was presented blocked per criterion and substantial evidence that distraction improved decision quality when the information was presented blocked per option. Finally, Study 2 revealed that the recollection of decision-relevant details mediated the effect of presentation format on decision quality in the deliberation condition. This suggests that recollection contributes to conscious deliberation efficacy.

  20. Childrens' Recollections of the Falklands Crisis: A Small-Scale Exploration.

    Science.gov (United States)

    McKelvey, Joyce

    1984-01-01

    Children in Great Britain were asked about their recollections of the Falklands crisis six months after it ended. Children recalled facts, sequences of events, their feelings, and media coverage of the war. Implications of these findings on what is seen as normal and the formation of nationalistic attitudes are discussed. (Author/IS)

  1. Disregarding Familiarity during Recollection Attempts: Content-Specific Recapitulation as a Retrieval Orientation Strategy

    Science.gov (United States)

    Gray, Stephen J.; Gallo, David A.

    2015-01-01

    People can use a content-specific recapitulation strategy to trigger memories (i.e., mentally reinstating encoding conditions), but how people deploy this strategy is unclear. Is recapitulation naturally used to guide all recollection attempts, or is it only used selectively, after retrieving incomplete information that requires additional…

  2. Recollection-Dependent Memory for Event Duration in Large-Scale Spatial Navigation

    Science.gov (United States)

    Brunec, Iva K.; Ozubko, Jason D.; Barense, Morgan D.; Moscovitch, Morris

    2017-01-01

    Time and space represent two key aspects of episodic memories, forming the spatiotemporal context of events in a sequence. Little is known, however, about how temporal information, such as the duration and the order of particular events, are encoded into memory, and if it matters whether the memory representation is based on recollection or…

  3. Recognition Errors Suggest Fast Familiarity and Slow Recollection in Rhesus Monkeys

    Science.gov (United States)

    Basile, Benjamin M.; Hampton, Robert R.

    2013-01-01

    One influential model of recognition posits two underlying memory processes: recollection, which is detailed but relatively slow, and familiarity, which is quick but lacks detail. Most of the evidence for this dual-process model in nonhumans has come from analyses of receiver operating characteristic (ROC) curves in rats, but whether ROC analyses…

  4. How FlAsH got its sparkle: historical recollections of the biarsenical-tetracysteine tag.

    Science.gov (United States)

    Griffin, B Albert; Adams, Stephen R; Tsien, Roger Y

    2015-01-01

    The biarsenical-tetracysteine tagging system was the first of (and inspiration for) the now numerous methods for site-specifically labeling proteins in living cells with small molecules such as fluorophores. This historical recollection describes its conception and the trial-and-error chemical development required to become a versatile technique.

  5. Consciousness CLEARS the mind.

    Science.gov (United States)

    Grossberg, Stephen

    2007-11-01

    A full understanding of consciousness requires that we identify the brain processes from which conscious experiences emerge. What are these processes, and what is their utility in supporting successful adaptive behaviors? Adaptive Resonance Theory (ART) predicted a functional link between processes of Consciousness, Learning, Expectation, Attention, Resonance and Synchrony (CLEARS), including the prediction that "all conscious states are resonant states". This connection clarifies how brain dynamics enable a behaving individual to autonomously adapt in real time to a rapidly changing world. The present article reviews theoretical considerations that predicted these functional links, how they work, and some of the rapidly growing body of behavioral and brain data that have provided support for these predictions. The article also summarizes ART models that predict functional roles for identified cells in laminar thalamocortical circuits, including the six layered neocortical circuits and their interactions with specific primary and higher-order specific thalamic nuclei and nonspecific nuclei. These predictions include explanations of how slow perceptual learning can occur without conscious awareness, and why oscillation frequencies in the lower layers of neocortex are sometimes slower beta oscillations, rather than the higher-frequency gamma oscillations that occur more frequently in superficial cortical layers. ART traces these properties to the existence of intracortical feedback loops, and to reset mechanisms whereby thalamocortical mismatches use circuits such as the one from specific thalamic nuclei to nonspecific thalamic nuclei and then to layer 4 of neocortical areas via layers 1-to-5-to-6-to-4.

  6. Multiple chromophobe and clear cell renal cancer in a patient affected by Birt-Hogg-Dubè syndrome: a case report.

    Science.gov (United States)

    Castellucci, Roberto; Marchioni, Michele; Valenti, Sergio; Sortino, Giuseppe; Borgonovo, Giulio; Pesenti, Nicola; Vismara, Alberto C A; Circo, Maria C; Sessa, Barbara; Micheli, Emanuele; Lembo, Antonino

    2017-04-28

    Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant characterized by the presence of fibrofolliculomas and/or trichodiscomas, pulmonary cysts, spontaneous pneumothorax, and renal tumors. The syndrome is linked to mutations in the FLCN gene, which is preferentially expressed in the skin, kidney, and lung. The aim of our paper is to describe a case of multiple bilateral renal cancer in a patient affected by BHDS. Patient subjected to enucleoresection seven kidney tumors discovered right after ultrasound performed for other reasons. Definitive histologic examination were as follows: multifocal type chromophobe renal cell carcinoma and clear cell. After 1 month, the patient was readmitted for spontaneous pneumothorax. After about a year, the patient was again subjected to resection of multiple renal tumors left. Histological examination proved that it was multifocal renal cell carcinoma, clear cell varieties. The genome analysis highlighted positive for mutation c. 1379_1380 of FLCN gene, BHDS gene. Currently, the patient is under close follow-up. After 1 year, the chest computed tomography (CT) confirmed the presence of minute air bubbles scattered on both sides. Instead, the abdominal CT was positive for a small round lesion 6 mm exophytic. The BHDS is a rare syndrome whose management is extremely complex both in terms of oncological and functional. Kidney tumors associated with BHDS usually have a favorable clinical course. Present evidence suggests a close follow-up of the carriers of the genetic mutation patients whether or not they have expressed the lesions of disease given the high rate of recurrence of renal lesions.

  7. Retrieval orientation and the control of recollection: an fMRI study.

    Science.gov (United States)

    Morcom, Alexa M; Rugg, Michael D

    2012-12-01

    This study used event-related fMRI to examine the impact of the adoption of different retrieval orientations on the neural correlates of recollection. In each of two study-test blocks, participants encoded a mixed list of words and pictures and then performed a recognition memory task with words as the test items. In one block, the requirement was to respond positively to test items corresponding to studied words and to reject both new items and items corresponding to the studied pictures. In the other block, positive responses were made to test items corresponding to pictures, and items corresponding to words were classified along with the new items. On the basis of previous ERP findings, we predicted that in the word task, recollection-related effects would be found for target information only. This prediction was fulfilled. In both tasks, targets elicited the characteristic pattern of recollection-related activity. By contrast, nontargets elicited this pattern in the picture task, but not in the word task. Importantly, the left angular gyrus was among the regions demonstrating this dissociation of nontarget recollection effects according to retrieval orientation. The findings for the angular gyrus parallel prior findings for the "left-parietal" ERP old/new effect and add to the evidence that the effect reflects recollection-related neural activity originating in left ventral parietal cortex. Thus, the results converge with the previous ERP findings to suggest that the processing of retrieval cues can be constrained to prevent the retrieval of goal-irrelevant information.

  8. Treatment of teeth in the esthetic zone in a patient with amelogenesis imperfecta using composite veneers and the clear matrix technique: A case report

    OpenAIRE

    Bogosavljević Aleksandar; Mišina Vanja; Jordačević Jovana; Abazović Milka; Dukić Smiljka; Ristić Ljubiša; Daković Dragana

    2016-01-01

    Introduction. Restorative dental treatment of patients with a generalized form of amelogenesis imperfecta (AI) remains a challenge even today. The treatment approach is multidisciplinary and includes action of several dental disciplines such as restorative, orthodontic, and prosthetic dental specialties. Case report. A 18-year-old female patent was referred to the Department of Restorative Dentistry and Periodontology at the Military Medical Academy of Belg...

  9. BAP1 is overexpressed in black compared with white patients with Mx-M1 clear cell renal cell carcinoma: A report from the cancer genome atlas.

    Science.gov (United States)

    Paulucci, David J; Sfakianos, John P; Yadav, Shalini Singh; Badani, Ketan K

    2016-06-01

    Incidence of renal cell carcinoma (RCC) is higher in Black patients with disease-specific and overall survival being lower compared with White patients even though renal tumors among Black patients are more likely to be localized. These disparities have been attributed to higher rates of obesity and hypertension, lower rates of nephrectomy, and a lack of access to quality health care. With scant genomic evidence to account for these disparities, the present study sought to compare BAP1 expression between Black and White patients with clear cell RCC (ccRCC); a gene that inhibits tumor progression when overexpressed and results in poor clinical outcomes when silenced. The cancer genome atlas dataset was used to identify 58 (9.9%) Black and 529 (90.9%) White patients with ccRCC with an initial pathologic diagnosis from 1998 to 2013. BAP1 expression was compared using a Mann-Whitney U test. The association between BAP1 expression and pathologic stage, American Joint Committee on Cancer (AJCC) stage, and Fuhrman grade was assessed for the overall cohort and stratified by race. The association between BAP1 expression and overall survival was assessed using Cox proportion hazards models adjusting for Fuhrman grade, pathologic stage, and the presence of pathologic metastases for the overall cohort and stratified by race. The level of BAP1 expression was significantly higher in Black vs. White patients with ccRCC (10.5 vs. 10.3; P<.001). For the overall cohort, increasing BAP1 expression was associated with decreasing pathologic stage (β =-0.25, P = .004) and decreasing AJCC stage (β =-0.029, P = .006). For Black patients, increasing BAP1 expression was associated with decreasing AJCC stage (β =-0.79, P = .016), decreasing Fuhrman grade (β =-0.55, P = .011), and a decreased risk of pathologic metastases (odds ratio [OR] = 0.83, P = .038). For White patients, increasing BAP1 expression was associated with decreasing pathologic stage (β =-0.20, P = .026). BAP1 is

  10. Verochka Zingan or recollections from the Physics Department of the Moscow University

    Science.gov (United States)

    Gaina, Alex; Gaina, Danielle A.

    The author recollects his studentship during 70-th years at the Physics Department of the Moscow University. He was graduated from the theoretical Physics Department in 1977. The Rectors of the University that times were I.G. Petrovskii, R.V. Khokhlov and A.A. Logunov. The dean of the Physics Department was V.S. Fursov. As a particular event a meet with the former prime-minister of the USSR A.N. Kosygin is reported. Between professors mentioned throughout the recollections are A.I.Kitaigorodskii, Ya. B. Zel'dovich, D.D. Ivanenko, A.A. Sokolov, A.A. Vlasov, V.B. Braginsky, I.M. Ternov, L.A. Artsimovich, E.P. Velikhov and other, including that which became University professors later. A great number of colleagues from the Physics, Chemistry, Phylological and Historical Departments of the Moscow University are mentioned. Particularly, the students which entered the group 113 in 1971 and finished the group 601 in 1977 are listed. The recollections include 5 parts. Persons cited throughout the paper: A.N. Kosygin, A.S. Golovin, V. Kostyukevich, I.M. Ternov, E.G. Pozdnyak, A. N. Matveev, V.P. Elyutin, V.V. Kerzhentsev, 113 academic group (1971), V. Topala, E.A. Marinchuk, P.Paduraru, A.I. Kitaygorodski, A. Leahu, S. Berzan, B. Ursu, I. Coanda (Koade), M. Stefanovici, O. Bulgaru, A. Iurie-Apostol, A.S. Davydov, M.I. Kaganov, I.M. Lifshitz, Ya. B. Zel'dovich, A.Zhukov, A.I. Buzdin, N.S. Perov, V. Dolgov, P. Vabishchevich, A.A. Samarskii, V. Makarov, Irina Kamenskih, A.A. Arsen'ev, L.A. Artsimovich, A.A. Tyapkin, B.M. Pontecorvo, D.I. Blokhintsev, I.G. Petrovskii, R.V. Khokhlov, V.N. Rudenko, A.A. Sokolov, D.D. Ivanenko (Iwanenko), A.A. Vlasov, V.N. Ponomarev, N.N. Bogolyubov, N.N. Bogolyubov (Jr), V.Ch. Zhukovskii, Tamara Tarasova, Zarina Radzhabova (Malovekova), V.Malovekov, Tatiana Shmeleva, Alexandra C.Nicolescu, Tatiana Nicolescu, Rano Mahkamova, Miriam Yandieva, Natalia Germaniuk (Grigor'eva), E. Grigor'ev, A. Putro, Elena Nikiforova, B. Kostrykin, Galia Laufer, K

  11. Clean energy clear opportunity : a report on the human resources best practices and recommendations raised during the 2010 Canada-United States clean energy dialogue forum

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    Since American and Canadian electricity markets are significantly integrated, neither country can afford to act in isolation on issues of electricity generation, transmission and use. This document presented a report on the human resources best practices and recommendations raised during the 2010 Canada-United States clean energy dialogue forum, with particular reference to the electricity sector workforce. Experts from government, electricity companies, educational institutions and industry associations attended the forum and identified several best practices and offered recommendations. Best practices were reported under the following 2 headings: in the face of a labour shortage; and in the face of new technologies and infrastructure. Some of the best practices under a labour shortage situation include engaging in strategic workforce planning; creating a culture of safety; promoting opportunities in the electricity sector; appealing to the interests and values of young people; enhancing workforce diversity; and transferring knowledge from senior workers to younger employees. In the face of new technologies and infrastructure, the best practices include the creation of operating and safety standards for new technologies; providing access to quality training programs; improving the availability of educational resources; and managing skills assessment and development. It was concluded that Canada and the United States are neighbours and trade partners and that over the coming years, they have the opportunity to become each other's best allies in the pursuit of clean energy objectives.

  12. Are lung imaging reporting and data system categories clear to radiologists? A survey of the Korean Society of Thoracic Radiology members on ten difficult -to classify scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Han, Dae Hee; Ahn, Myeong Im [Dept. of Radiology, Seoul St. Mary' s Hospital, College of Medicine, The Catholic University of Korea, Seoul (Korea, Republic of); Goo, Jin Mo [Dept. of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul (Korea, Republic of); Chong, Se Min [Dept. of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul (Korea, Republic of)

    2017-04-15

    To evaluate possible variability in chest radiologists' interpretations of the Lung Imaging Reporting and Data System (Lung-RADS) on difficult-to-classify scenarios. Ten scenarios of difficult-to-classify imaginary lung nodules were prepared as an online survey that targeted Korean Society of Thoracic Radiology members. In each question, a description was provided of the size, consistency, and interval change (new or growing) of a lung nodule observed using annual repeat computed tomography, and the respondent was instructed to choose one answer from five choices: category 2, 3, 4A, or 4B, or 'un-categorizable.' Consensus answers were established by members of the Korean Imaging Study Group for Lung Cancer. Of the 420 answers from 42 respondents (excluding multiple submissions), 310 (73.8%) agreed with the consensus answers; eleven (26.2%) respondents agreed with the consensus answers to six or fewer questions. Assigning the imaginary nodules to categories higher than the consensus answer was more frequent (16.0%) than assigning them to lower categories (5.5%), and the agreement rate was below 50% for two scenarios. When given difficult-to-classify scenarios, chest radiologists showed large variability in their interpretations of the Lung-RADS categories, with high frequencies of disagreement in some specific scenarios.

  13. Unusual clear cell variant of epithelioid mesothelioma.

    Science.gov (United States)

    Dessy, E; Falleni, M; Braidotti, P; Del Curto, B; Panigalli, T; Pietra, G G

    2001-12-01

    Clear cell mesothelioma is an extremely rare neoplasm of the pleura, which can easily be mistaken for a metastasis of clear cell carcinoma to the pleura. We report here the histochemical, immunohistochemical, and ultrastructural aspects of a new case of clear cell pleural mesothelioma in a 52-year-old man with no known asbestos exposure. He was admitted to the hospital for recurrent pleural effusion, which was negative for neoplastic cells at the cytologic examination. A partial decortication of the right pleura was performed. The morphologic, immunohistochemical, and ultrastructural features reported for this case are consistent with the diagnosis of clear cell mesothelioma. The differential diagnosis and immunohistochemical features in comparison with other clear cell neoplasms are discussed.

  14. Electrophysiological indices of memory for temporal order in early childhood: implications for the development of recollection.

    Science.gov (United States)

    Riggins, Tracy; Miller, Neely C; Bauer, Patricia J; Georgieff, Michael K; Nelson, Charles A

    2009-03-01

    The ability to recall contextual details associated with an event begins to develop in the first year of life, yet adult levels of recall are not reached until early adolescence. Dual-process models of memory suggest that the distinct retrieval process that supports the recall of such contextual information is recollection. In the present investigation, we used both behavioral and electrophysiological measures to assess the development of memory for contextual details, as indexed by memory for temporal order, in early childhood. Results revealed age-related improvements in memory for temporal order despite similar levels of memory for the individual items themselves. Furthermore, this pattern of recall was associated with specific components in the electrophysiological response. Consistent with electrophysiological research in adults, distributed, positive-going activity late in the waveform was associated with increases in recall of contextual details and the development of recollective processes.

  15. Reconstructing intimate violence: the structure and content of recollections of violent events.

    Science.gov (United States)

    Eisikovits, Zvi; Winstok, Zeev

    2002-05-01

    The purpose of this article is to explore the structure and content of recollections of violent events among cohabiting partners. The authors used qualitative methodology to examine 48 in-depth interviews. Content analysis of the interviews yielded two parallel and interrelated continua: One represented the life circumstances (staying in spite of violence) impinging on the recollections; the other dealt with the content of the memories of violent events. These two interacted according to a series of structural features. Both men and women living in violent relationships described a contextual variation ranging from choosing to stay to being prevented from leaving. The memory of violence was constructed in a manner meant to achieve coherence with the appropriate context.

  16. Do you remember proposing marriage to the Pepsi machine? False recollections from a campus walk.

    Science.gov (United States)

    Seamon, John G; Philbin, Morgan M; Harrison, Liza G

    2006-10-01

    During a campus walk, participants were given familiar or bizarre action statements (e.g., "Check the Pepsi machine for change" vs. "Propose marriage to the Pepsi machine") with instructions either to perform the actions or imagine performing the actions (Group 1) or to watch the experimenter perform the actions or imagine the experimenter performing the actions (Group 2). One day later, some actions were repeated, along with new actions, on a second walk. Two weeks later, the participants took a recognition test for actions presented during the first walk, and they specified whether a recognized action was imagined or performed. Imagining themselves or the experimenter performing familiar or bizarre actions just once led to false recollections of performance for both types of actions. This study extends previous research on imagination inflation by demonstrating that these false performance recollections can occur in a natural, real-life setting following just one imagining.

  17. Differential Effects of Stress-induced Cortisol Responses on Recollection and Familiarity-based Recognition Memory

    OpenAIRE

    McCullough, Andrew M.; Ritchey, Maureen; Ranganath, Charan; Yonelinas, Andrew

    2015-01-01

    Stress-induced changes in cortisol can impact memory in various ways. However, the precise relationship between cortisol and recognition memory is still poorly understood. For instance, there is reason to believe that stress could differentially affect recollection-based memory, which depends on the hippocampus, and familiarity-based recognition, which can be supported by neocortical areas alone. Accordingly, in the current study we examined the effects of stress-related changes in cortisol o...

  18. Does Harm Avoidance mediate effects of recollected parental bonding on mental distress in adulthood?

    DEFF Research Database (Denmark)

    Stenbæk, D S; Jensen, C G; Holst, K K

    2014-01-01

    Adverse early life conditions such as perceived low quality of parental bonding increase vulnerability to stress and psychopathology in adulthood. However, the mechanisms by which perceptions of parental bonding translate into vulnerability are unclear and remain sparsely investigated in healthy ...... populations. We proposed a model, in which the personality trait Harm Avoidance would mediate effects of recollected parental bonding during the first sixteen years of life on measures of perceived stress and mental distress severity in adulthood....

  19. Impaired familiarity with preserved recollection after anterior temporal-lobe resection that spares the hippocampus.

    Science.gov (United States)

    Bowles, Ben; Crupi, Carina; Mirsattari, Seyed M; Pigott, Susan E; Parrent, Andrew G; Pruessner, Jens C; Yonelinas, Andrew P; Köhler, Stefan

    2007-10-09

    It is well established that the medial-temporal lobe (MTL) is critical for recognition memory. The MTL is known to be composed of distinct structures that are organized in a hierarchical manner. At present, it remains controversial whether lower structures in this hierarchy, such as perirhinal cortex, support memory functions that are distinct from those of higher structures, in particular the hippocampus. Perirhinal cortex has been proposed to play a specific role in the assessment of familiarity during recognition, which can be distinguished from the selective contributions of the hippocampus to the recollection of episodic detail. Some researchers have argued, however, that the distinction between familiarity and recollection cannot capture functional specialization within the MTL and have proposed single-process accounts. Evidence supporting the dual-process view comes from demonstrations that selective hippocampal damage can produce isolated recollection impairments. It is unclear, however, whether temporal-lobe lesions that spare the hippocampus can produce selective familiarity impairments. Without this demonstration, single-process accounts cannot be ruled out. We examined recognition memory in NB, an individual who underwent surgical resection of left anterior temporal-lobe structures for treatment of intractable epilepsy. Her resection included a large portion of perirhinal cortex but spared the hippocampus. The results of four experiments based on three different experimental procedures (remember-know paradigm, receiver operating characteristics, and response-deadline procedure) indicate that NB exhibits impaired familiarity with preserved recollection. The present findings thus provide a crucial missing piece of support for functional specialization in the MTL.

  20. Recollection and familiarity in aging individuals with mild cognitive impairment and Alzheimer's disease: a literature review.

    Science.gov (United States)

    Schoemaker, Dorothee; Gauthier, Serge; Pruessner, Jens C

    2014-09-01

    Memory impairment is a central cognitive symptom in mild cognitive impairment (MCI) and Alzheimer Disease (AD). Recognition tasks are often used to characterize and define the nature of memory deficits. Dual-process theories posit that familiarity and recollection are independently involved in the recognition of previously encountered material and both contribute to successful recognition. Recent evidence indicates that there is a double dissociation in the neuronal substrates of those two processes. More precisely, it has been suggested that perirhinal and entorhinal areas are selectively involved in familiarity-based recognition, while the hippocampus is associated with recollection. Interestingly, these regions are among the first to be targeted by neurofibrillary tangles, one of AD's neuropathological hallmarks. Impairment in recognition performance can occur in the very early stages of AD, such as MCI. To define the nature of recognition impairment in these clinical populations, we reviewed the current literature on familiarity and recollection performance in individuals with MCI and AD. Together with clinical features, methodological factors are taken into consideration in the interpretation of findings.

  1. [Effects of recollection and familiarity on recognition memory in the Concealed Information Test].

    Science.gov (United States)

    Zaitsu, Wataru; Shibuya, Yusuke

    2013-08-01

    The effects of recollection and familiarity on recognition memory in the Concealed Information Test (CIT) were investigated. In the learning phase, participants encoded 20 words that were presented in one of four frames on a personal computer screen. Next, in the recognition test, the participants were divided into "Remember judgment (Recollection)" or "Know judgment (Familiarity)" groups, based on their Remember/Know judgment when recognizing learned items. In the CIT phase, physiological responses to questions about learned (i.e., critical) and non-learned (i.e., non-critical) items were measured and recorded. The results indicated that there was a deceleration of respiration speed (RS), an increase in skin conductance response (SCR), and a drop in heart rate in responses to critical items for both groups. Furthermore, the effect sizes of RS and SCR were greater in the "Remember judgment" group compared to the "Know judgment" group. These results suggest that critical response patterns are generated by recollection and familiarity. However, the more vividly participants recognized critical items the larger were the magnitudes of RS and SCR response patterns.

  2. The relationship between recollection, knowledge transfer, and student attitudes towards chemistry

    Science.gov (United States)

    Odeleye, Oluwatobi Omobonike

    Certain foundational concepts, including acid-base theory, chemical bonding and intermolecular forces (IMFs), appear throughout the undergraduate chemistry curriculum. The level of understanding of these foundational concepts influences the ability of students to recognize the relationships between sub-disciplines in chemistry. The purpose of this study was to investigate the relationship between student attitudes towards chemistry and their abilities to recollect and transfer knowledge of IMFs, a foundational concept, to their daily lives as well as to other classes. Data were collected using surveys, interviews and classroom observations, and analyzed using qualitative methods. The data show that while most students were able to function at lower levels of thinking by providing a definition of IMFs, majority were unable to function at higher levels of thinking as evidenced by their inability to apply their knowledge of IMFs to their daily lives and other classes. The results of this study suggest a positive relationship between students' abilities to recollect knowledge and their abilities to transfer that knowledge. The results also suggest positive relationships between recollection abilities of students and their attitudes towards chemistry as well as their transfer abilities and attitudes towards chemistry. Recommendations from this study include modifications of pedagogical techniques in ways that facilitate higher-level thinking and emphasize how chemistry applies not only to daily life, but also to other courses.

  3. Déjà vu experiences in healthy subjects are unrelated to laboratory tests of recollection and familiarity for word stimuli

    Directory of Open Access Journals (Sweden)

    Akira Robert O'Connor

    2013-11-01

    Full Text Available Recent neuropsychological and neuroscientific research suggests that people who experience more déjà vu display characteristic patterns in normal recognition memory. We conducted a large individual differences study (n = 206 to test these predictions using recollection and familiarity parameters recovered from a standard memory task. Participants reported déjà vu frequency and a number of its correlates, and completed a recognition memory task analogous to a Remember-Know procedure. The individual difference measures replicated an established correlation between déjà vu frequency and frequency of travel, and recognition performance showed well-established word frequency and accuracy effects. Contrary to predictions, no relationships were found between déjà vu frequency and recollection or familiarity memory parameters from the recognition test. We suggest that déjà vu in the healthy population reflects a mismatch between errant memory signalling and memory monitoring processes not easily characterised by standard recognition memory task performance.

  4. Xp11 translocation renal cell carcinoma morphologically mimicking clear cell-papillary renal cell carcinoma in an adult patient: report of a case expanding the morphologic spectrum of Xp11 translocation renal cell carcinomas.

    Science.gov (United States)

    Parihar, Asmita; Tickoo, Satish K; Kumar, Sunil; Arora, Vinod Kumar

    2015-05-01

    Xp11 translocation renal cell carcinoma (RCC) is a relatively rare tumor mainly affecting children and adolescents. It shows significant morphological overlap with the 2 most common adult renal tumors, which are the clear cell (conventional) RCC and papillary RCC. We describe case of a young adult female who presented with right flank pain and abdominal mass. Radiological investigations showed features suggestive of renal cell carcinoma in the right kidney. Histopathological findings while suggestive of Xp11 carcinoma, showed significant overlap with the recently described entity clear cell papillary RCC. TFE3 immunohistochemistry confirmed the tumor to be Xp11 translocation RCC. The patient had an aggressive course with lymph node metastasis. In this report, we discuss differential diagnosis and the diagnostic challenges of Xp11 translocation RCC in adults.

  5. The management of clear cell sarcoma

    NARCIS (Netherlands)

    Kuiper, DR; Hoekstra, HJ; Veth, RPH; Wobbes, T

    2003-01-01

    Clear cell sarcoma is a rare soft tissue tumour, constituting approximately 1% of all soft tissue sarcomas. Prognosis is reported to be poor due to the great propensity to metastasise regionally and distantly. In this paper, we report the surgical experience of two university hospitals. Both disease

  6. Clear cell myoepithelial carcinoma ex pleomorphic adenoma

    Directory of Open Access Journals (Sweden)

    Nikhil R Rabade

    2014-01-01

    Full Text Available Pleomorphic adenoma is the most common epithelial neoplasm of lacrimal gland. A clear cell myoepithelial carcinoma arising in the background of pleomorphic adenoma is common in the salivary glands but very rare in the lacrimal glands. We report the case of a 27 year old man whose lacrimal gland pleomorphic adenoma recurred several times over a period of four years and ultimately evolved into a clear cell myoepithelial carcinoma ex pleomorphic adenoma.

  7. Media Language, Clear or Obscure

    DEFF Research Database (Denmark)

    Jakobsen, Bjarne le Fevre; Ejstrup, Michael

    2015-01-01

    Abstract— Be clear, not obscure. One of the four maxims for optimal communication is that it is essential to develop proficiency in being concise and clear. The question is whether this is really a good idea in all contexts. There is some evidence to the contrary. Undoubtedly, we have many contex...... for the survival of free speech....

  8. Encoding-related brain activity dissociates between the recollective processes underlying successful recall and recognition: a subsequent-memory study.

    Science.gov (United States)

    Sadeh, Talya; Maril, Anat; Goshen-Gottstein, Yonatan

    2012-07-01

    The subsequent-memory (SM) paradigm uncovers brain mechanisms that are associated with mnemonic activity during encoding by measuring participants' neural activity during encoding and classifying the encoding trials according to performance in the subsequent retrieval phase. The majority of these studies have converged on the notion that the mechanism supporting recognition is mediated by familiarity and recollection. The process of recollection is often assumed to be a recall-like process, implying that the active search for the memory trace is similar, if not identical, for recall and recognition. Here we challenge this assumption and hypothesize - based on previous findings obtained in our lab - that the recollective processes underlying recall and recognition might show dissociative patterns of encoding-related brain activity. To this end, our design controlled for familiarity, thereby focusing on contextual, recollective processes. We found evidence for dissociative neurocognitive encoding mechanisms supporting subsequent-recall and subsequent-recognition. Specifically, the contrast of subsequent-recognition versus subsequent-recall revealed activation in the Parahippocampal cortex (PHc) and the posterior hippocampus--regions associated with contextual processing. Implications of our findings and their relation to current cognitive models of recollection are discussed. Copyright © 2012 Elsevier Ltd. All rights reserved.

  9. When expectation meets experience: parents' recollections of and experiences with a child diagnosed with hearing loss soon after birth.

    Science.gov (United States)

    Gilliver, Megan; Ching, Teresa Y C; Sjahalam-King, Jessica

    2013-12-01

    To examine parents' recollections of and their experiences with bringing up a child diagnosed with hearing loss at a very young age. Based on the analysis of informal parent discussion groups, four open-ended questions were formulated to solicit information about parents' expectations following diagnosis, as well as experiences and challenges when raising a child with a hearing loss. Forty parents of children, aged between three to five years, who were diagnosed with hearing loss before the age of three years. Parents' responses revealed strong support for early intervention, high expectations for their child's development, and desire for information tailored to individual needs. Parents also reported anxiety relating to their perceptions of the significance of consistent device usage on their child's development. Further concerns arose from their observations of the difficulties experienced by their child in real-world environments despite consistent device usage, and their perception of their child's language delay despite early intervention. The findings point to a need to support parents to form realistic expectations based on current knowledge. Implications for clinicians to provide improved management of children with hearing loss are discussed.

  10. WHEN EXPECTATION MEETS EXPERIENCE: PARENTS’ RECOLLECTIONS OF AND EXPERIENCES WITH A CHILD DIAGNOSED WITH HEARING LOSS SOON AFTER BIRTH

    Science.gov (United States)

    Gilliver, Megan; Ching, Teresa YC; Sjahalam-King, Jessica

    2013-01-01

    Objective To examine parents’ recollections of and their experiences with bringing up a child diagnosed with hearing loss at a very young age. Design Based on the analysis of informal parent discussion groups, four open-ended questions were formulated to solicit information about parents’ expectations following diagnosis, as well as experiences and challenges when raising a child with a hearing loss. Study Sample Forty parents of children, aged between three to five years, who were diagnosed with hearing loss before the age of three years. Results Parents’ responses revealed strong support for early intervention, high expectations for their child’s development, and desire for information tailored to individual needs. Parents also reported anxiety relating to their perceptions of the significance of consistent device usage on their child’s development. Further concerns arose from their observations of the difficulties experienced by their child in real-world environments despite consistent device usage, and their perception of their child’s language delay despite early intervention. Conclusions The findings point to a need to support parents to form realistic expectations based on current knowledge. Implications for clinicians to provide improved management of children with hearing loss are discussed. PMID:24350690

  11. Students’ Digital Photography Behaviors during a Multiday Environmental Science Field Trip and Their Recollections of Photographed Science Content

    Directory of Open Access Journals (Sweden)

    Victor R. Lee

    2014-01-01

    Full Text Available Taking photographs to document the experiences of an educational field trip is becoming a common activity for teachers and students alike. Considering the regular creation of photographic artifacts, our goal in this paper is to explore students’ picture taking behavior and their recollections of science content associated with their photographs. In this study, we partnered with a class of fifth-grade students in the United States and provided each student with a digital camera to document their experiences during an environmental science field trip at a national park. We report the frequency of photography behaviors according to which activities were most often documented by the students and specifically that students tended to document more of their experiences when they were in outdoor, natural spaces rather than inside of visitor centers or museums. Also, through an analysis of students’ comments about the science content captured in their photographs we observe that students’ comments about photographs of the outdoors tended to show greater depth and complexity than those that were taken in indoor, museum-like spaces.

  12. Clear cell odontogenic carcinoma: A rare case

    Directory of Open Access Journals (Sweden)

    Garima Jain

    2015-01-01

    Full Text Available Clear cell odontogenic carcinoma is a rare neoplasm with very few cases reported in the literature. We report a case of a 50-year-old female patient with the malignancy at a less common location. Diagnosis was given based on the histopathologic findings. The demographic data and understanding for this tumor needs to be strengthened by reporting all new cases, which are diagnosed, in literature.

  13. Resting-state functional connectivity of ventral parietal regions associated with attention reorienting and episodic recollection

    Directory of Open Access Journals (Sweden)

    Sander M Daselaar

    2013-02-01

    Full Text Available In functional neuroimaging studies, ventral parietal cortex (VPC is recruited by very different cognitive tasks. Explaining the contributions VPC to these tasks has become a topic of intense study and lively debate. Perception studies frequently find VPC activations during tasks involving attention-reorienting, and memory studies frequently find them during tasks involving episodic recollection. According to the Attention to Memory (AtoM model, both phenomena can be explained by the same VPC function: bottom-up attention. Yet, a recent functional MRI (fMRI meta-analysis suggested that attention-reorienting activations are more frequent in anterior VPC, whereas recollection activations are more frequent in posterior VPC. Also, there is evidence that anterior and posterior VPC regions have different functional connectivity patterns. To investigate these issues, we conducted a resting-state functional connectivity analysis using as seeds the center-of-mass of attention-reorienting and recollection activations in the meta-analysis, which were located in the supramarginal gyrus (SMG, around the temporo-parietal junction—TPJ and in the angular gyrus (AG, respectively. The SMG seed showed stronger connectivity with ventrolateral prefrontal cortex (VLPFC and occipito-temporal cortex, whereas the AG seed showed stronger connectivity with the hippocampus and default network regions. To investigate whether these connectivity differences were graded or sharp, VLPFC and hippocampal connectivity was measured in VPC regions traversing through the SMG and AG seeds. The results showed a graded pattern: VLPFC connectivity gradually decreases from SMG to AG, whereas hippocampal connectivity gradually increases from SMG to AG. Importantly, both gradients showed an abrupt break when extended beyond VPC borders. This finding suggests that functional differences between SMG and AG are more subtle than previously thought. These connectivity differences can be

  14. Media Language, Clear or Obscure

    DEFF Research Database (Denmark)

    Jakobsen, Bjarne le Fevre; Ejstrup, Michael

    2015-01-01

    Abstract— Be clear, not obscure. One of the four maxims for optimal communication is that it is essential to develop proficiency in being concise and clear. The question is whether this is really a good idea in all contexts. There is some evidence to the contrary. Undoubtedly, we have many contex...... for the survival of free speech....... growth in diversity, means that media need to be very cognizant of the stringency with which they handle the advice to be linguistically clear and concise. The need to pay great attention to situational awareness is highly visible and intrusive. Attention to situational awareness seems to be crucial...

  15. Forest clearing and regional landsliding

    Science.gov (United States)

    Montgomery, D.R.; Schmidt, K.M.; Greenberg, H.M.; Dietrich, W.E.

    2000-01-01

    The influence of forest clearing on landsliding is central to longstanding concern over the effects of timber harvesting on slope stability. Here we document a strong topographic control on shallow landsliding by combining unique ground-based landslide surveys in an intensively monitored study area with digital terrain modeling using high-resolution laser altimetry and a coarser resolution regional study of 3224 landslides. As predicted by our digital terrain-based model, landslides occur disproportionately in steep, convergent topography. In terrain predicted to be at low risk of slope failure, a random model performs equally well to our mechanism-based model. Our monitoring shows that storms with 24 hr rainfall recurrence intervals of less than 4 yr triggered landslides in the decade after forest clearing and that conventional monitoring programs can substantially underestimate the effects of forest clearing. Our regional analysis further substantiates that forest clearing dramatically accelerates shallow landsliding in steep terrain typical of the Pacific Northwest.

  16. Formula Recollection through a WORLDLY recognized mnemonic technique

    Science.gov (United States)

    Schunicht, Shannon

    2010-03-01

    This discovery directly resulted from this author's head injury- (19 days unconsciousness). Beginning with some essential Brain Facts to explain how this remarkable discovery was devised: Right hemisphere => Spatial/musical Left hemisphere => Language/Logic This authors education: 2 ea BA degrees (language requirement) and a hole in the head (right hemisphere) may be spied on attendance verify such. The damaged right hemisphere accentuates this author's left hemisphere coupled with 2ea BA degrees that require a language ('83 BA a/Spanish & '94 BA w/Latin). Physical survival may be attributed to US Army RANGER training who Never say die! 10-82, 11-82, & 13 83 Recovery came having to learn EVERYTHING all over again, as I was reported having displayed upon awakening from the extended unconsciousness (19 days). Studies were difficult without a memory, but simple because I had always been forced to learn EVERYTHING MYSELF by mother who was a kindergarten teacher! The residual deficit continues to plague this author: Out of Sight is truly Out of mind! Even for a student whose memory is NOT disabled, memory is difficult. The ``nut's & bolts'' of this presentation are essentially having each Vowel represent a Mathematical operation. A: multiplication => @ O: division => Over I: sUbraction => mInus U: addition => plUs E => => => Equals Most constants and variables are indeed consonants, e.g. c = speed of light z = altitude

  17. An animal model of amnesia that uses Receiver Operating Characteristics (ROC) analysis to distinguish recollection from familiarity deficits in recognition memory.

    Science.gov (United States)

    Eichenbaum, H; Fortin, N; Sauvage, M; Robitsek, R J; Farovik, A

    2010-07-01

    Here we review our development of an animal model of episodic memory and amnesia that employs a signal detection analyses to characterize recognition memory performance in rats. This approach aims to distinguish episodic recollection of studied items from mere familiarity for recently experienced stimuli, and then to examine the neural basis of these memory processes. Our findings on intact animals indicate that it is possible to distinguish independent components of recognition that are associated with features of recollection and familiarity in humans. Furthermore, we have found that damage limited to the hippocampus results in a selective deficit in recollection and not familiarity. Also, aging and prefrontal damage result in a similar pattern of impaired recollection and spared familiarity. However, whereas the recollection deficit following hippocampal damage can be attributed to the forgetting of studied materials, the impairment following prefrontal damage is due to false alarms, likely reflecting a deficit in source monitoring.

  18. Optical clearing at cellular level

    Science.gov (United States)

    Kinnunen, Matti; Bykov, Alexander V.; Tuorila, Juho; Haapalainen, Tomi; Karmenyan, Artashes V.; Tuchin, Valery V.

    2014-07-01

    Strong light scattering in tissues and blood reduces the usability of many optical techniques. By reducing scattering, optical clearing enables deeper light penetration and improves resolution in several optical imaging applications. We demonstrate the usage of optical tweezers and elastic light scattering to study optical clearing [one of the major mechanisms-matching of refractive indices (RIs)] at the single particle and cell level. We used polystyrene spheres and human red blood cells (RBCs) as samples and glycerol or glucose water solutions as clearing agents. Optical tweezers kept single microspheres and RBCs in place during the measurement of light scattering patterns. The results show that optical clearing reduces the scattering cross section and increases g. Glucose also decreased light scattering from a RBC. Optical clearing affected the anisotropy factor g of 23.25-μm polystyrene spheres, increasing it by 0.5% for an RI change of 2.2% (20% glycerol) and 0.3% for an RI change of 1.1% (13% glucose).

  19. Recollection of episodic memory within the medial temporal lobe: behavioural dissociations from other types of memory.

    Science.gov (United States)

    Easton, Alexander; Eacott, Madeline J

    2010-12-31

    In recent years there has been significant debate about whether there is a single medial temporal lobe memory system or dissociable systems for episodic and other types of declarative memory. In addition there has been a similar debate over the dissociability of recollection and familiarity based processes in recognition memory. Here we present evidence from recent work using episodic memory tasks in animals that allows us to explore these issues in more depth. We review studies that demonstrate triple dissociations within the medial temporal lobe, with only the hippocampal system being necessary for episodic memory. Similarly we review behavioural evidence for a dissociation in a task of episodic memory in rats where animals with lesions of the fornix are only impaired at recollection of the episodic memory, not recognition within the same trial. This work, then, supports recent models of dissociable neural systems within the medial temporal lobe but also raises questions for future investigation about the interactions of these medial temporal lobe memory systems with other structures. Copyright © 2009 Elsevier B.V. All rights reserved.

  20. On failed intersubjectivity: Recollections of loneliness experiences in offspring of Holocaust survivors.

    Science.gov (United States)

    Wiseman, Hadas

    2008-07-01

    Intergenerational consequences of extensive trauma experienced by parents for the loneliness experienced by their children were explored in 52 adults (26 men and 26 women) who grew up in Holocaust survivor families. These adults, children of mothers who had survived Nazi concentration camps, were recruited from a random nonclinical Israeli sample. A narrative analysis of their recollected accounts of loneliness in childhood and adolescence yielded 4 major categories of loneliness experiences in the context of growing up in Holocaust survivor families: (a) echoes of parental intrusive traumatic memories; (b) echoes of parental numbing and detachment; (c) perceived parents' caregiving style; and (d) social comparison with other families, in particular the lack of grandparents. The echoes of the parental trauma in the recollected loneliness accounts are conceptualized as representing a sense of failed intersubjectivity in these interpersonal processes. The experiences of not being understood by others, not understanding others, and the lack of shared understanding involved in failed intersubjectivity are discussed and related to the importance of opening lines of communication between survivors and their descendents.

  1. True Memory, False Memory, and Subjective Recollection Deficits after Focal Parietal Lobe Lesions

    Science.gov (United States)

    Drowos, David B.; Berryhill, Marian; André, Jessica M.; Olson, Ingrid R.

    2010-01-01

    Objective There is mounting evidence that the posterior parietal cortex (PPC) plays an important role in episodic memory. We previously found that patients with PPC damage exhibit retrieval-related episodic memory deficits. Our objective was to assess whether parietal lobe damage affects episodic memory on a different task: the Deese-Roediger-McDermott (DRM) false-memory paradigm. Method Two patients with bilateral PPC damage and matched controls were tested. In Experiment 1, the task was to remember words; in Experiment 2 the task was to remember pictures of common objects. Prior studies have shown that normal participants have high levels of false memory to words, low levels to pictures. Results The patients exhibited significantly lower levels of false memory to words. The patients' false memories were accompanied by reduced levels of recollection, as tested by a Remember/Know procedure. It is unlikely that a failure of gist processing accounts for these results, as patients accurately remembered thematic elements of short vignettes, but failed to remember details. These results support the view that portions of the PPC play a critical role in objective and subjective aspects of recollection. PMID:20604621

  2. Typography and color: effects of salience and fluency on conscious recollective experience.

    Science.gov (United States)

    Wehr, Thomas; Wippich, Werner

    2004-12-01

    Within one experiment the central assumptions of the distinctiveness/fluency account of recollective experience were tested and contrasted with predictions of processing theory. To manipulate perceptual salience, the typography of words was varied. Effects of conceptual salience were induced by a variation of word color. In the study phase participants generated different word or object images according to presented words. To manipulate perceptual and conceptual fluency one test group underwent a priming procedure in the test phase, consisting of a recognition test, whereby some primes were identical to the target words typographically or by color and others were not. Additionally, all participants were asked to make judgments of recollective experience (remember, know, guess) after the old/new decisions. The results of the data analyses confirm the distinctiveness/fluency account. Words written in an unusual typography or color were judged significantly more often as "remembered" than normal words. The priming procedure uncovered some effects of fluency on reaction times: old/new decisions took less time if prime and target words were perceptually or conceptually identical.

  3. Clear Thinking about Alternative Therapies

    Science.gov (United States)

    ... for a multilevel marketing organization (known as “pyramid marketing”) 15 | Clear Thinking about Alternative Therapies Look before you leap n Don’t make your decision in a vacuum. Contact a variety of sources to get reliable, objective information about any alternative therapy you are considering. ...

  4. Clear plastic cups: a childhood choking hazard.

    Science.gov (United States)

    Weiss, R L; Goldstein, M N; Dharia, A; Zahtz, G; Abramson, A L; Patel, M

    1996-11-01

    The disposable plastic beverage cup is not usually regarded as hazardous to young children. Certain varieties of these products however, are manufactured from a brittle, clear plastic that easily cracks and fragments. While most conscientious parents keep their children safe from peanuts, balloons, and other known choking hazards, a child can surreptitiously bite a cup edge and aspirate the fragment. We report two cases of foreign body aspiration involving clear plastic cups that went undetected one of which remained 21 months following a negative rigid bronchoscopy. Diagnostic difficulties are related to the transparency and radiolucency of these objects. When suspicious of foreign body aspiration in children, otolaryngologists should inquire about the availability of clear plastic cups in the household and be mindful of the diagnostic pitfalls. Further investigations including CT scanning and repeat bronchoscopy may be helpful in cases of suspected missed foreign bodies. An educational campaign aimed at prevention and placement of product package warning labels should be established.

  5. Familiarity and Recollection Produce Distinct Eye Movement, Pupil and Medial Temporal Lobe Responses when Memory Strength Is Matched

    Science.gov (United States)

    Kafkas, Alexandros; Montaldi, Daniela

    2012-01-01

    Two experiments explored eye measures (fixations and pupil response patterns) and brain responses (BOLD) accompanying the recognition of visual object stimuli based on familiarity and recollection. In both experiments, the use of a modified remember/know procedure led to high confidence and matched accuracy levels characterising strong familiarity…

  6. The Development of Father-Child Attachment: Associations between Adult Attachment Representations, Recollections of Childhood Experiences and Caregiving

    Science.gov (United States)

    McFarland-Piazza, Laura; Hazen, Nancy; Jacobvitz, Deborah; Boyd-Soisson, Erin

    2012-01-01

    The association between fathers' adult attachment representations and their recollections of childhood experiences with their caregiving quality with their eight-month-old infants and with father-infant attachment classification was examined in a longitudinal study of 117 fathers and their infants. Sensitive caregiving was related to…

  7. Two types of recollection-based monitoring in younger and older adults: Recall-to-reject and the distinctiveness heuristic.

    Science.gov (United States)

    Gallo, David A; Bell, Deborah M; Beier, Jonathan S; Schacter, Daniel L

    2006-08-01

    People often use recollection to avoid false memories. At least two types of recollection-based monitoring processes can be identified in the literature. Recall-to-reject is based on the recall of logically inconsistent information (which disqualifies the false event from having occurred), whereas the distinctiveness heuristic is based on the failure to recall to-be-expected information (which is diagnostic of non-occurrence). We attempted to investigate these hypothetical monitoring processes in a single task, as a first step at delineating the functional relationship between them. By design, participants could reject familiar lures by (1) recalling them from a to-be-excluded list (recall-to-reject) or (2) realising the absence of expected picture recollections (the distinctiveness heuristic). Both manipulations reduced false recognition in young adults, suggesting that these two types of monitoring were deployed on the same test. In contrast, older adults had limited success in reducing false recognition with either manipulation, indicating deficits in recollection-based monitoring processes. Depending on how a retrieval task is structured, attempts to use one monitoring process might interfere with another, especially in older adults.

  8. Recollections of Parent Characteristics and Attachment Patterns for College Women of Intact vs. Non-Intact Families

    Science.gov (United States)

    Kilmann, Peter R.; Carranza, Laura V.; Vendemia, Jennifer M. C.

    2006-01-01

    This study contrasted offsprings' attachment patterns and recollections of parent characteristics in two college samples: 147 females from intact biological parents and 157 females of parental divorce. Secure females from intact or non-intact families rated parents positively, while insecure females rated parents as absent, distant, and demanding.…

  9. Understanding Foreign Future and Deconstructing Polish Past: The Experiences of Schooling under a Communist Rule Recollected by Contemporary Polish Migrants

    Science.gov (United States)

    Pustulka, Paula; Slusarczyk, Magdalena

    2016-01-01

    The article elaborates on the recollections of schooling under the communist rule in Poland as presented in biographical interviews with contemporary Polish migrants living in the United Kingdom, Germany, and Norway. An analysis of childhood and schooling nexus is elicited on two platforms, specifically as (1) interviewees' first-hand experiences…

  10. Resting-state functional connectivity of ventral parietal regions associated with attention reorienting and episodic recollection

    Science.gov (United States)

    Daselaar, S. M.; Huijbers, W.; Eklund, K.; Moscovitch, M.; Cabeza, R.

    2013-01-01

    In functional neuroimaging studies, ventral parietal cortex (VPC) is recruited by very different cognitive tasks. Explaining the contributions of VPC to these tasks has become a topic of intense study and lively debate. Perception studies frequently find VPC activations during tasks involving attention-reorienting, and memory studies frequently find them during tasks involving episodic recollection. According to the Attention to Memory (AtoM) model, both phenomena can be explained by the same VPC function: bottom-up attention. Yet, a recent functional MRI (fMRI) meta-analysis suggested that attention-reorienting activations are more frequent in anterior VPC, whereas recollection activations are more frequent in posterior VPC. Also, there is evidence that anterior and posterior VPC regions have different functional connectivity patterns. To investigate these issues, we conducted a resting-state functional connectivity analysis using as seeds the center-of-mass of attention-reorienting and recollection activations in the meta-analysis, which were located in the supramarginal gyrus (SMG, around the temporo-parietal junction—TPJ) and in the angular gyrus (AG), respectively. The SMG seed showed stronger connectivity with ventrolateral prefrontal cortex (VLPFC) and occipito-temporal cortex, whereas the AG seed showed stronger connectivity with the hippocampus and default network regions. To investigate whether these connectivity differences were graded or sharp, VLPFC and hippocampal connectivity was measured in VPC regions traversing through the SMG and AG seeds. The results showed a graded pattern: VLPFC connectivity gradually decreases from SMG to AG, whereas hippocampal connectivity gradually increases from SMG to AG. Importantly, both gradients showed an abrupt break when extended beyond VPC borders. This finding suggests that functional differences between SMG and AG are more subtle than previously thought. These connectivity differences can be explained by

  11. The art of thinking clearly

    CERN Document Server

    Dobelli, Rolf

    2013-01-01

    The Art of Thinking Clearly by world-class thinker and entrepreneur Rolf Dobelli is an eye-opening look at human psychology and reasoning — essential reading for anyone who wants to avoid “cognitive errors” and make better choices in all aspects of their lives. Have you ever: Invested time in something that, with hindsight, just wasn’t worth it? Or continued doing something you knew was bad for you? These are examples of cognitive biases, simple errors we all make in our day-to-day thinking. But by knowing what they are and how to spot them, we can avoid them and make better decisions. Simple, clear, and always surprising, this indispensable book will change the way you think and transform your decision-making—work, at home, every day. It reveals, in 99 short chapters, the most common errors of judgment, and how to avoid them.

  12. Writing clear animal activity proposals.

    Science.gov (United States)

    Pinson, David M

    2011-06-01

    Although IACUC-related topics are frequently discussed in the literature, there is little published information about how to write animal activity proposals. In this article, the author discusses key considerations in the writing and review of animal activity proposals. The author then describes a framework for developing and writing clear animal activity proposals that highlight animal welfare concerns. Though these recommendations are aimed at individuals writing and reviewing research proposals, the framework can be modified for other types of animal activity proposals.

  13. The effects of unitization on the contribution of familiarity and recollection processes to associative recognition memory: evidence from event-related potentials.

    Science.gov (United States)

    Zheng, Zhiwei; Li, Juan; Xiao, Fengqiu; Broster, Lucas S; Jiang, Yang; Xi, Mingjing

    2015-03-01

    Familiarity and recollection are two independent cognitive processes involved in recognition memory. It is traditionally believed that both familiarity and recollection can support item recognition, whereas only recollection can support associative recognition. Here, using a standard associative recognition task, we examined whether associative retrieval of unitized associations involved differential patterns of familiarity and recollection processes relative to non-unitized associations. The extent of engagement of familiarity and recollection processes during associative retrieval was estimated by using event-related potentials (ERPs). Twenty participants studied compound words and unrelated word pairs during encoding. Subsequently, they were asked to decide whether a presented word pair was intact, rearranged, or a new pair while electroencephalogram (EEG) was recorded. ERP results showed that compound words evoked a significant early frontal old/new effect (associated with familiarity) between ERPs to intact and rearranged word pairs, whereas this effect disappeared for the unrelated word pairs. In addition, the left parietal old/new effect (associated with recollection) between ERPs to intact and rearranged word pairs was greater for compounds than for unrelated word pairs. These findings suggest that unitization enhances the contribution of both familiarity and recollection processes to associative recognition.

  14. Key features of human episodic recollection in the cross-episode retrieval of rat hippocampus representations of space.

    Directory of Open Access Journals (Sweden)

    Eduard Kelemen

    2013-07-01

    Full Text Available Neurophysiological studies focus on memory retrieval as a reproduction of what was experienced and have established that neural discharge is replayed to express memory. However, cognitive psychology has established that recollection is not a verbatim replay of stored information. Recollection is constructive, the product of memory retrieval cues, the information stored in memory, and the subject's state of mind. We discovered key features of constructive recollection embedded in the rat CA1 ensemble discharge during an active avoidance task. Rats learned two task variants, one with the arena stable, the other with it rotating; each variant defined a distinct behavioral episode. During the rotating episode, the ensemble discharge of CA1 principal neurons was dynamically organized to concurrently represent space in two distinct codes. The code for spatial reference frame switched rapidly between representing the rat's current location in either the stationary spatial frame of the room or the rotating frame of the arena. The code for task variant switched less frequently between a representation of the current rotating episode and the stable episode from the rat's past. The characteristics and interplay of these two hippocampal codes revealed three key properties of constructive recollection. (1 Although the ensemble representations of the stable and rotating episodes were distinct, ensemble discharge during rotation occasionally resembled the stable condition, demonstrating cross-episode retrieval of the representation of the remote, stable episode. (2 This cross-episode retrieval at the level of the code for task variant was more likely when the rotating arena was about to match its orientation in the stable episode. (3 The likelihood of cross-episode retrieval was influenced by preretrieval information that was signaled at the level of the code for spatial reference frame. Thus key features of episodic recollection manifest in rat hippocampal

  15. Medial temporal lobe function and recognition memory: a novel approach to separating the contribution of recollection and familiarity.

    Science.gov (United States)

    Song, Zhuang; Jeneson, Annette; Squire, Larry R

    2011-11-02

    Human neuroimaging studies of recognition memory have often been interpreted to mean that the hippocampus supports recollection but not familiarity. This interpretation is complicated by the fact that recollection-based decisions are typically associated with stronger memories than familiarity-based decisions. Some studies of source memory controlled for this difference in memory strength and found that hippocampal activity during learning predicted subsequent item memory strength while recollection-based memory (performance on source memory questions) was held at chance. This result suggests that the hippocampus is important for familiarity. However, a difficulty with this approach is that when source memory is assessed by asking specific, task-relevant source memory questions, participants who fail to answer the prescribed questions might nevertheless have available other (task-irrelevant) source information. Accordingly, successful item memory could still be associated with recollection. The present study used a novel method to assess item memory and source memory. Instead of responding to specific source questions, participants rated their source memory strength based on any information about the learning episode that was available to them. When subsequent source memory strength was held constant at the lowest possible level, we identified regions bilaterally in hippocampus, as well as in perirhinal cortex, where activity during learning increased as subsequent item memory increased in strength. In addition, activity in cortical regions (including prefrontal cortex) was related to source memory success independently of item memory strength. These findings suggest that activity in the hippocampus is related to the encoding of familiarity-based item memory, independent of subsequent recollection-based success.

  16. Field test of the Cognitive Interview: enhancing the recollection of actual victims and witnesses of crime.

    Science.gov (United States)

    Fisher, R P; Geiselman, R E; Amador, M

    1989-10-01

    The Cognitive Interview was tested in the field to enhance the recollection of actual victims and witnesses of crime. The technique is based on laboratory-tested principles of memory retrieval, knowledge representation, and communication. Seven experienced detectives from the Metro-Dade Police Department were trained to use the technique and were compared with 9 untrained detectives. Before and after training, all detectives tape-recorded interviews with victims and witnesses of crime. The trained detectives elicited 47% more information after than before training, and 63% more information than did the untrained detectives. Overall collaboration rates (94%) were extremely high and were equivalent for pre- and posttrained interviews. Because the Cognitive Interview reliably enhances memory and is easily learned and administered, it should be useful for a variety of investigative interviews.

  17. [Effects of recollecting autobiographical memories on the emotional well-being of older adults].

    Science.gov (United States)

    Westerhof, G J; Lamers, S M A; de Vries, D R S L

    2010-02-01

    This experiment examined the effect of different ways of recollecting autobiographical memories on emotional well-being. Participants between 65 and 80 years old (N = 70) were instructed to write about a memory from their life when they were 15 to 30 years old. They were asked to do this in a narrative way about a positive memory, in a narrative way about a negative memory or in an interpretative way about a negative memory. We also examined whether spontaneous reminiscence types in everyday life moderate the effects of the experimental manipulation on emotional well-being. Narrating positive memories is more favourable for negative affect than narrating or interpreting negative memories. There is no moderating role for everyday reminiscence types, even though these are related to emotional well-being. Manipulated and spontaneous reminiscence are therefore different. This is a favourable finding for reminiscence interventions, because they can stimulate positive memories, no matter how older people are used to memorize their past.

  18. Ion clearing in an ERL

    Science.gov (United States)

    Hoffstaetter, Georg H.; Liepe, Matthias

    2006-02-01

    The rest-gas in the beam-pipe of a particle accelerator is readily ionized by effects like collisions, synchrotron radiation and field emission. Positive ions are attracted to electron beams and create a nonlinear potential in the vicinity of the beam which can lead to beam halo, particle loss, optical errors or transverse and longitudinal instabilities. In an energy recovery linac (ERL) where beam-loss has to be minimal, and where beam positions and emittances have to be very stable in time, these ion effects have to be avoided. Here we investigate three measures of avoiding ion accumulation: (a) A long gap between linac bunch trains that allows ions to drift out of the beam region, a measure regularly applied in linacs; (b) a short ion clearing gap in the beam that leads to a time varying beam potential and produces large excited oscillations of ions around the electron beam, a measure regularly applied in storage rings; (c) Clearing electrodes that create a sufficient voltage to draw ions out of the beam potential, a measure used for DC electron beams and for antiproton beams. For the parameters of the X-ray ERL planned at Cornell University we show that method (a) cannot be applied, method (b) is technically cumbersome, and (c) should be most easily applicable.

  19. Central Clearing of OTC Derivatives

    DEFF Research Database (Denmark)

    Cont, Rama; Kokholm, Thomas

    2014-01-01

    is determined by the tradeoff between multilateral netting across dealers on one hand and bilateral netting across asset classes on the other hand. We find this tradeoff to be sensitive to assumptions on heterogeneity of asset classes in terms of `riskyness' of the asset class as well as correlation...... classes are realistically taken into account. We argue that empirically plausible specifications of model parameters lead to the conclusion that central clearing does reduce interdealer exposures: the gain from multilateral netting in a CCP overweighs the loss of netting across asset classes in bilateral...... netting agreements. When a CCP exists for interest rate derivatives, adding a CCP for credit derivatives is shown to decrease overall exposures. These findings are shown to be robust to the statistical assumptions of the model as well as the choice of risk measure used to quantify exposures....

  20. Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland.

    Science.gov (United States)

    Arik, Deniz; Dündar, Emine; Yilmaz, Evrim; Sivrikoz, Cumhur

    2017-10-06

    Water-clear cell adenoma of the parathyroid gland is a rare neoplasm that consists of cells with abundant clear-pink cytoplasm. There have only been 19 cases reported in the English literature. Here we report a case of water-clear cell adenoma of the mediastinal parathyroid gland. A 70-year-old male patient presented to the hospital with back pain and a mediastinal mass 6 cm in size was detected. After excision and microscopic evaluation, uniform, large clear cells with fine cytoplasmic vacuolization, without nuclear atypia, and arranged in solid and acinar patterns were revealed. The cells formed nests that were separated by fine fibrovascular septae and stained positively with anti-parathyroid hormone. To the best of our knowledge, this has not been previously reported in this location. In the differential diagnosis of clear cell lesions of the mediastinum, water-clear cell parathyroid adenoma should be considered.

  1. Optical clearing of vaginal tissues

    Science.gov (United States)

    Chang, Chun-Hung; Myers, Erinn M.; Kennelly, Michael J.; Fried, Nathaniel M.

    2017-02-01

    Near-IR laser energy in conjunction with applied tissue cooling is being investigated for thermal remodeling of endopelvic fascia during minimally invasive treatment of female stress urinary incontinence. Previous simulations of light transport, heat transfer, and tissue thermal damage have shown that a transvaginal approach is more feasible than a transurethral approach. However, undesirable thermal insult to vaginal wall was predicted. This study explores whether an optical clearing agent (OCA) can improve optical penetration depth and completely preserve vaginal wall during subsurface treatment of endopelvic fascia. Several OCA mixtures were tested, and 100% glycerol was found to be optimal. Optical transmission studies, optical coherence tomography, reflection spectroscopy, and computer simulations of thermal damage to tissue using glycerol were performed. The OCA produced a 61% increase in optical transmission through porcine vaginal wall at 37 °C after 30 min. Monte Carlo (MC) light transport, heat transfer, and Arrhenius integral thermal damage simulations were performed. MC model showed improved energy deposition in endopelvic fascia using OCA. Without OCA, 62, 37, and 1% of energy was deposited in vaginal wall, endopelvic fascia, and urethral wall, compared with 50, 49, and 1% with OCA. Use of OCA also yielded 0.5 mm increase in treatment depth, allowing potential thermal tissue remodeling at 3 mm depth.

  2. Malignant Clear Cell Hidradenoma of the Breast

    Science.gov (United States)

    Rahal, Ahmad K.; Reddy, Pavan S; Kallail, K. James

    2017-01-01

    A 58-year-old female had a mass in the right breast palpable beneath the areola. A mammogram revealed a 1.5-centimeter soft tissue density that was confirmed with a subsequent ultrasound. The patient underwent a core needle biopsy which was initially reported as a moderately differentiated invasive ductal carcinoma. Immunohistochemical analysis revealed negative staining for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor (HER2), mammaglobin, and gross cystic disease fluid protein 15 (GCDFP-15). A wide local excision of the mass was performed. The pathology report stated the tumor had an infiltrative growth pattern with a desmoplastic stromal response with enhanced epithelial atypia consistent with malignant transformation of a nodular clear cell hidradenoma. Clear cell hidradenoma is a very rare tumor originating from the sweat gland and has a propensity for the face and extremities. The malignant variant of this tumor is extremely rare and has been reported to originate from the breast in few cases. This case represents the difficulty in diagnosing this tumor along with the radiographic and histologic features that can distinguish this malignancy from other entities.

  3. The tangled trail from Topeka to Houston: the Menninger Clinic-mid-1999 to mid-2003: a personal recollection.

    Science.gov (United States)

    McKelvey, John

    2011-01-01

    This article traces many of the key events during the move of the Menninger Clinic from Topeka, Kansas, to Houston, Texas, and the affiliation with the Baylor College of Medicine and the Methodist Hospital in Houston. It is based on the personal recollections of John McKelvey, who was involved, in some form, in almost all aspects of the decision to move, the selection of the Houston location, the affiliation negotiations, and the final implementation of the relocation.

  4. Electrophysiological Correlates of Familiarity and Recollection in Associative Recognition: Contributions of Perceptual and Conceptual Processing to Unitization.

    Science.gov (United States)

    Li, Bingcan; Mao, Xinrui; Wang, Yujuan; Guo, Chunyan

    2017-01-01

    It is generally accepted that associative recognition memory is supported by recollection. In addition, recent research indicates that familiarity can support associative memory, especially when two items are unitized into a single item. Both perceptual and conceptual manipulations can be used to unitize items, but few studies have compared these two methods of unitization directly. In the present study, we investigated the effects of familiarity and recollection on successful retrieval of items that were unitized perceptually or conceptually. Participants were instructed to remember either a Chinese two-character compound or unrelated word-pairs, which were presented simultaneously or sequentially. Participants were then asked to recognize whether word-pairs were intact or rearranged. Event-related potential (ERP) recordings were performed during the recognition phase of the study. Two-character compounds were better discriminated than unrelated word-pairs and simultaneous presentation was found to elicit better discrimination than sequential presentation for unrelated word-pairs only. ERP recordings indicated that the early intact/rearranged effects (FN400), typically associated with familiarity, were elicited in compound word-pairs with both simultaneous and sequential presentation, and in simultaneously presented unrelated word-pairs, but not in sequentially presented unrelated word-pairs. In contrast, the late positive complex (LPC) effects associated with recollection were elicited in all four conditions. Together, these results indicate that while the engagement of familiarity in associative recognition is affected by both perceptual and conceptual unitization, conceptual unitization promotes a higher level of unitization (LOU). In addition, the engagement of recollection was not affected by unitized manipulations. It should be noted, however, that due to experimental design, the effects presented here may be due to semantic rather than episodic memory and

  5. Recognition memory strength is predicted by pupillary responses at encoding while fixation patterns distinguish recollection from familiarity.

    Science.gov (United States)

    Kafkas, Alexandros; Montaldi, Daniela

    2011-10-01

    Thirty-five healthy participants incidentally encoded a set of man-made and natural object pictures, while their pupil response and eye movements were recorded. At retrieval, studied and new stimuli were rated as novel, familiar (strong, moderate, or weak), or recollected. We found that both pupil response and fixation patterns at encoding predict later recognition memory strength. The extent of pupillary response accompanying incidental encoding was found to be predictive of subsequent memory. In addition, the number of fixations was also predictive of later recognition memory strength, suggesting that the accumulation of greater visual detail, even for single objects, is critical for the creation of a strong memory. Moreover, fixation patterns at encoding distinguished between recollection and familiarity at retrieval, with more dispersed fixations predicting familiarity and more clustered fixations predicting recollection. These data reveal close links between the autonomic control of pupil responses and eye movement patterns on the one hand and memory encoding on the other. Moreover, the data illustrate quantitative as well as qualitative differences in the incidental visual processing of stimuli, which are differentially predictive of the strength and the kind of memory experienced at recognition.

  6. Linking University Students’ Willingness to Learn to Their Recollections of Motivation at Secondary School

    Directory of Open Access Journals (Sweden)

    Julia Gorges

    2013-11-01

    Full Text Available This study investigated the role of recollected school-based motivation on university students’ willingness to use new learning opportunities. Following Eccles’ expectancy-value theory, willingness to learn was conceptualized as task value, which has been found to predict task choice in previous empirical studies. Based on three motivational theories, we suggest two broad motivational dimensions for an economic description of motivational orientations, inward and outward, that should differentially predict the formation of task value. German university students (N = 1580 were asked about their task value for receiving their instructions in English as a foreign language at university and, retrospectively, their motivation in English language class at secondary school. Principal components analysis and confirmatory factor analyses of motivational variables yielded a two-factor solution supporting the differentiation between inward and outward motivational orientation. Inward motivational orientation at school was positively linked to students’ task value in adulthood, even if the individual’s self-concept of ability was controlled. The effects of outward motivation were rather small and tended to be counterproductive. Our findings suggest a complex interplay between past and present motivation and self-concept of ability underlying one’s willingness to learn and to participate in education.

  7. Anticipation of novelty recruits reward system and hippocampus while promoting recollection.

    Science.gov (United States)

    Wittmann, Bianca C; Bunzeck, Nico; Dolan, Raymond J; Düzel, Emrah

    2007-10-15

    The dopaminergic midbrain, which comprises the substantia nigra and ventral tegmental area (SN/VTA), plays a central role in reward processing. This region is also activated by novel stimuli, raising the possibility that novelty and reward have shared functional properties. It is currently unclear whether functional aspects of reward processing in the SN/VTA, namely, activation by unexpected rewards and cues that predict reward, also characterize novelty processing. To address this question, we conducted an fMRI experiment during which subjects viewed symbolic cues that predicted either novel or familiar images of scenes with 75% validity. We show that SN/VTA was activated by cues predicting novel images as well as by unexpected novel images that followed familiarity-predictive cues, an 'unexpected novelty' response. The hippocampus, a region implicated in detecting and encoding novel stimuli, showed an anticipatory novelty response but differed from the response profile of SN/VTA in responding at outcome to expected and 'unexpected' novelty. In a behavioral extension of the experiment, recollection increased relative to familiarity when comparing delayed recognition memory for anticipated novel stimuli with unexpected novel stimuli. These data reveal commonalities in SN/VTA responses to anticipating reward and anticipating novel stimuli. We suggest that this anticipatory response codes a motivational exploratory novelty signal that, together with anticipatory activation of the hippocampus, leads to enhanced encoding of novel events. In more general terms, the data suggest that dopaminergic processing of novelty might be important in driving exploration of new environments.

  8. Preserved hippocampal novelty responses following anterior temporal-lobe resection that impairs familiarity but spares recollection.

    Science.gov (United States)

    Bowles, Ben; O'Neil, Edward B; Mirsattari, Seyed M; Poppenk, Jordan; Köhler, Stefan

    2011-08-01

    Although it is well established that the integrity of the medial temporal lobe (MTL) is critical for declarative memory, the functional organization of the MTL remains a matter of intense debate. One issue that has received little consideration so far is whether the hippocampus can function normally in the presence of a lesion to perirhinal cortex that produces noticeable memory impairments. This question is intriguing as the MTL forms a hierarchical system, in which perirhinal cortex represents one of the critical nodes in the reciprocal projections between neocortical association areas and the hippocampus. Here, we used functional magnetic resonance imaging to examine whether NB, an individual who underwent surgical resection of the left anterior temporal lobe that included large aspects of perirhinal and entorhinal cortex but spared the hippocampus, exhibits intact hippocampal novelty responses to auditory sentences. Our results revealed such evidence in NB's left and right hippocampus. They complement previous behavioral work in NB, indicating that recollective processes considered to rely on hippocampal integrity are also preserved. Further analyses revealed intact novelty responses in structures that provide neuroanatomical input to the hippocampus, including remaining perirhinal cortex and surgically spared parahippocampal cortex. These findings point to viable neuroanatomical mechanisms as to how functional integrity in the hippocampus may be maintained in the face of widespread, but incomplete removal of its input structures.

  9. [Clear cell carcinoma of the parotid gland].

    Science.gov (United States)

    Mazouzi, A; Benjelloun, H; Benchekroun, N; Acharki, A; Benider, A

    2005-06-01

    Clear cell carcinomas of the parotid gland are hardly reported only fifty cases are known. They are characterized by a proliferation of acinic epithelial cells and of clear myo epithelial cells. What makes them remarkable is a slow process of evolution. Three cases which were treated in the Ibn Rochd center of oncology are gathered from the 1999-2003 period into a review in order to discover the epidemic and anatomopathological characteristics of these tumours. The goal of study is to contribute to a best knowledge of the clinical features, pare clinical, anatomopathological and therapeutic characteristic of this tumour. Two men, aged of 62 and 71 and a 82-years-old-woman were concerned. Growing cervical mass was the most revealing symptom. The diagnosis was established by the parotid biopsy in 2 cases and after surgery in the third case. The treatment consisted in a total parotidectomy with conservation of the facial nerve and postoperative radiation at the extend of 65 Gy for the first patient. After 12 months the patient is still alive. As for the two other patients, given the extend of advancement of the tumour, palliative treatment was decided. It resulted in stabilization of the disease and a receding of 22 months for one patient and no trace of the second one because of a loss of the evolutionary pursuit. With an in-depth analysis we can notice that clear cell carcinomas of the parotid gland are rare and mostly occur to old patients. Immunohistochemistry is the essential first step to sort these tumour with other salivary ones. Basic treatment is surgery. Radiation therapy linked to surgery seems to improve the local control of the disease. The prognosis remains relatively good despite discusses. Because of the few published cases, it's hard to analyze these tumours.

  10. When a Cleared Rape Is Not Cleared: A Multilevel Study of Arrest and Exceptional Clearance.

    Science.gov (United States)

    Walfield, Scott M

    2016-05-01

    As rape remains one of the most underreported and least likely to be cleared of the violent crimes, it is of paramount importance to understand the factors associated with the likelihood of a case being cleared by law enforcement. This study uses data from the National Incident-Based Reporting System (NIBRS) and the Law Enforcement Management and Administrative Statistics (LEMAS), and a multilevel modeling approach to examine the relationship between victim, offender, incident, and police department characteristics contrasting the two types of clearance: arrest and exceptional clearance. The latter occurs due to reasons outside of law enforcement's control and despite being considered cleared, the offender is not arrested, charged, nor turned over for prosecution. Of the 16,231 cleared rapes in 238 departments, nearly half (47%) results in exceptional clearance when the victim refuses to cooperate or when prosecution is declined. Incident-level variables have a greater effect on the likelihood of exceptional clearance than victim and offender variables. The department explained a nontrivial amount of variation in the dependent variable, as 37% of the variance in type of clearance was between-department variation. Implications for future research on exceptional clearance and NIBRS are discussed.

  11. The role of the prefrontal cortex in familiarity and recollection processes during verbal and non-verbal recognition memory: an rTMS study.

    Science.gov (United States)

    Turriziani, Patrizia; Smirni, Daniela; Oliveri, Massimiliano; Semenza, Carlo; Cipolotti, Lisa

    2010-08-01

    Neuroimaging and lesion studies have documented the involvement of the frontal lobes in recognition memory. However, the precise nature of prefrontal contributions to verbal and non-verbal memory and to familiarity and recollection processes remains unclear. The aim of the current rTMS study was to investigate for the first time the role of the DLPFC in encoding and retrieval of non-verbal and verbal memoranda and its contribution to recollection and familiarity processes. Recollection and familiarity processes were studied using the ROC and unequal variance signal detection methodologies. We found that rTMS delivered over left and right DLPFC at encoding resulted in material specific laterality effects with a disruption of recognition of verbal and non-verbal memoranda. Interestingly, rTMS over DLPFCs at encoding significantly affected both recollection and familiarity. However, at retrieval rTMS did not affect recollection and familiarity. Our results suggest that DLPFC has a degree of functional specialisation and plays an important role in the encoding of verbal and non-verbal memoranda.

  12. Old processes, new perspectives: Familiarity is correlated with (not independent of) recollection and is more (not equally) variable for targets than for lures.

    Science.gov (United States)

    Moran, Rani; Goshen-Gottstein, Yonatan

    2015-06-01

    According to dual-process models of memory, recognition is subserved by two processes: recollection and familiarity. Many variants of these models assume that recollection and familiarity make stochastically independent contributions to performance in recognition tasks and that the variance of the familiarity signal is equal for targets and for lures. Here, we challenge these 'common-currency' assumptions. Using a model-comparison approach, featuring the Continuous Dual Process (CDP; Wixted & Mickes, 2010) model as the protagonist, we show that when these assumptions are relaxed, the model's fits to individual participants' data improve. Furthermore, our analyses reveal that across items, recollection and familiarity show a positive correlation. Interestingly, this across-items correlation was dissociated from an across-participants correlation between the sensitivities of these processes. We also find that the familiarity signal is significantly more variable for targets than for lures. One striking theoretical implication of these findings is that familiarity-rather than recollection, as most models assume-may be the main contributor responsible for one of the most influential findings of recognition memory, that of subunit zROC slopes. Additionally, we show that erroneously adopting the common-currency assumptions, introduces severe biases to estimates of recollection and familiarity.

  13. [Recollections of the development of clinical cytology at Merkur University Hospital].

    Science.gov (United States)

    Crepinko, Inga

    2011-09-01

    My recollections of the development of clinical cytology at Merkur University Hospital cover a 30-year period, from 1955 to 1985, and succession of generations. The beginning is always exciting, pervaded by youthful enthusiasm, while memories are quite nostalgic. That is how I also felt at the "Ruzdić's" medical biochemistry laboratory. The founders of clinical cytology at Merkur University Hospital were the clinicians Erik Hauptmann (hematologist), Zdenko Skrabalo (endocrinologist) and Zvonimir Singer (gynecologist, cytogeneticist), with great contribution by Ibrahim Ruzdić (biochemist). As the first head of cytology laboratory at University Department of Medicine, I realized what was crucial for such a successful development of clinical cytology at our Hospital; it was so because new technologies were continuously introduced in agreement with clinicians, along with the basic routine cytodiagnosis, while paying special attention to staff education (postgraduate study in clinical cytology since 1967; residency in cytology since 1974; education of cytotechnologists since 1968). A number of MS theses and doctoral dissertations have been defended at our cytology laboratories. The Section of Cytology (now Croatian Society of Clinical Cytologists, Croatian Medical Association) was founded in 1970, owing to the efforts invested by E. Hauptmann. Clinical cytologists from Merkur University Hospital contributed to the foundation of the Association of Clinical Cytologists of the then Yugoslavia and organized their first congress in 1979; in 1972, we were adopted members of the EFCS, while Z. Singer and I. Crepinko are IAC members. I wish that written memories help remember the foundation and development of clinical cytology at Merkur University Hospital because we should not forget that every future has its origin.

  14. Literature and Cinema from "Adaptation" to Re-creation: Coping with the Complexity of Human Recollection

    Directory of Open Access Journals (Sweden)

    Carlo Testa

    2012-12-01

    Full Text Available Early 20th-century avant-gardes put a premium on the notion of "originality" and so created a cultural context in which "adaptation" -- in particular, lit-to cinema adaptation -- later came to be construed by film theory as a kind of derivative, inferior notion. This article offers the proof, based on work on the little-known original Russian sources, that none other than Èizenshtein opined differently, so much so that he preferred to argue instead for the use of the term "re-creation"; and that later semiotic theory, especially thanks to Iurii Lotman, provides us with the tools to develop the "re-creation" concept fully. In the process of re-creation, which is always a process of cultural re-contextualization, the original literary complexity lost in the transmutation must be made up in specific cinematic ways, in order to offer a final re-created artefact worthy of recollection by human society. In times of an overburdened human ability to remember historic sufferings, re-created artefacts that lose information vis-a-vis the original will be quite justly forgotten. On this basis, the article concludes with an elaboration on contemporary Italian cinema -- especially some commercially successful noirs -- drawn from literature (or rather, books of fiction and pinpoints the nature of one of that type of cinema's recurrent shortcomings. The essential defect of such films is identified in their inability to make up by cinematic means for the loss of complexity which they endure in the transition from one medium to another. This is all the more true when, as in the case of the noirs examined here, complexity is already scant in the original books in the first place.

  15. 17 CFR 39.4 - Procedures for implementing derivatives clearing organization rules and clearing new products.

    Science.gov (United States)

    2010-04-01

    ... derivatives clearing organization rules and clearing new products. 39.4 Section 39.4 Commodity and Securities... implementing derivatives clearing organization rules and clearing new products. (a) Request for approval of... of § 40.6 of this chapter. (c) Acceptance of new products for clearing. (1) A dormant...

  16. Production and perception of clear speech

    Science.gov (United States)

    Bradlow, Ann R.

    2003-04-01

    When a talker believes that the listener is likely to have speech perception difficulties due to a hearing loss, background noise, or a different native language, she or he will typically adopt a clear speaking style. Previous research has established that, with a simple set of instructions to the talker, ``clear speech'' can be produced by most talkers under laboratory recording conditions. Furthermore, there is reliable evidence that adult listeners with either impaired or normal hearing typically find clear speech more intelligible than conversational speech. Since clear speech production involves listener-oriented articulatory adjustments, a careful examination of the acoustic-phonetic and perceptual consequences of the conversational-to-clear speech transformation can serve as an effective window into talker- and listener-related forces in speech communication. Furthermore, clear speech research has considerable potential for the development of speech enhancement techniques. After reviewing previous and current work on the acoustic properties of clear versus conversational speech, this talk will present recent data from a cross-linguistic study of vowel production in clear speech and a cross-population study of clear speech perception. Findings from these studies contribute to an evolving view of clear speech production and perception as reflecting both universal, auditory and language-specific, phonological contrast enhancement features.

  17. Doctor talk: physicians' use of clear verbal communication.

    Science.gov (United States)

    Howard, Tera; Jacobson, Kara L; Kripalani, Sunil

    2013-08-01

    Low health literacy negatively affects processes and outcomes of care. Physicians do not routinely use communication techniques recommended for use with low health literate patients. This study was conducted to compare the self-reported and actual use of clear verbal communication among medical residents and to identify characteristics associated with clear communication. Residents self-assessed their communication behaviors and then completed a low health literacy standardized patient encounter. Answers on the self-assessment were compared with behaviors observed in the standardized patient encounter. Residents (N = 82) reported frequent use of techniques recommended for clear verbal communication, including plain language (88%) and teach-back (48%). However, during the standardized patient encounter, they used an average of 2 jargon terms per minute, and only 22% used teach-back. No resident characteristics consistently predicted better communication. In conclusion, the study found that medical residents used clear communication techniques infrequently and tended to overestimate the clarity with which they communicate.

  18. Neural processing of recollection, familiarity and priming at encoding: evidence from a forced-choice recognition paradigm.

    Science.gov (United States)

    Meng, Yingfang; Ye, Xiaohong; Gonsalves, Brian D

    2014-10-17

    The distinction between neural mechanisms of explicit and implicit expressions of memory has been well studied at the retrieval stage, but less at encoding. In addition, dissociations obtained in many studies are complicated by methodological difficulties in obtaining process-pure measures of different types of memory. In this experiment, we applied a subsequent memory paradigm and a two-stage forced-choice recognition test to classify study ERP data into four categories: subsequent remembered (later retrieved accompanied by detailed information), subsequent known (later retrieved accompanied by a feeling of familiarity), subsequent primed (later retrieved without conscious awareness) and subsequent forgotten (not retrieved). Differences in subsequent memory effects (DM effects) were measured by comparing ERP waveform associated with later memory based on recollection, familiarity or priming with ERP waveform for later forgotten items. The recollection DM effect involved a robust sustained (onset at 300 ms) prefrontal positive-going DM effect which was right-lateralized, and a later (onset at 800 ms) occipital negative-going DM effect. Familiarity involved an earlier (300-400 ms) prefrontal positive-going DM effect and a later (500-600 ms) parietal positive-going DM effect. Priming involved a negative-going DM effect which onset at 600 ms, mainly distributed over anterior brain sites. These results revealed a sequence of components that represented cognitive processes underlying the encoding of verbal information into episodic memory, and separately supported later remembering, knowing and priming.

  19. Overlap between the neural correlates of cued recall and source memory: evidence for a generic recollection network?

    Science.gov (United States)

    Hayama, Hiroki R.; Vilberg, Kaia L.

    2012-01-01

    Recall of a studied item and retrieval of its encoding context (source memory) both depend upon recollection of qualitative information about the study episode. The present study investigated whether recall and source memory engage overlapping neural regions. Subjects (N=18) studied a series of words which were presented either to the left or right of fixation. fMRI data were collected during a subsequent test phase in which three-letter word stems were presented, two-thirds of which could be completed by a study item. Instructions were to use each stem as a cue to recall a studied word and, when recall was successful, to indicate the word’s study location. When recall failed, the stem was to be completed with the first word to come to mind. Relative to stems for which recall failed, word stems eliciting successful recall were associated with enhanced activity in a variety of cortical regions, including bilateral parietal, posterior midline, and parahippocampal cortex. Activity in these regions was enhanced when recall was accompanied by successful rather than unsuccessful source retrieval. It is proposed that the regions form part of a ‘recollection network’ in which activity is graded according to the amount of information retrieved about a study episode. PMID:22288393

  20. Masked repetition priming hinders subsequent recollection but not familiarity: A behavioral and event-related potential study.

    Science.gov (United States)

    Li, Bingbing; Wang, Wei; Gao, Chuanji; Guo, Chunyan

    2016-10-01

    The present study used the masked repetition priming paradigm in the study phase and the R/K paradigm in the test phase to investigate whether repetition priming can hinder recognition memory and which recognition process (familiarity or recollection) is hindered. Event-related potentials (ERPs) in the study and test phase were recorded to explore the temporal course of how repetition priming hinders subsequent recognition memory and which old/new effect (FN400 or LPC) is affected. Converging behavioral and ERP results indicated that masked repetition priming hindered subsequent recollection but not familiarity. The analysis of ERP priming effects in the study phase indicated that primed words were associated with less negative N400 and less positive LPC compared to unprimed words. The analysis of the priming effect as a function of subsequent memory revealed that only the LPC priming effect was predictive of priming effect on subsequent memory, which suggested that the "prediction-error" account might be a possible explanation of how repetition priming affects subsequent recognition memory.

  1. An overview of botanical clearing technique.

    Science.gov (United States)

    Gardner, R O

    1975-03-01

    Clearing techniques are outlined with reference to their action on the chemical constituents of plant tissue. The most general technique would include pretreatment with solvents, dissolution of protoplasm, dissolution of other substances, bleaching, infiltration with a dense fluid, and staining. Extensive chemical changes go on during these steps and may prevent satisfactory clearing, an important example being the discoloration of phenolic compounds. Rational design of clearing methods for the chemically distinct cell types and tissue seems a likely future development.

  2. Intelligibility of Clear Speech: Effect of Instruction

    Science.gov (United States)

    Lam, Jennifer; Tjaden, Kris

    2013-01-01

    Purpose: The authors investigated how clear speech instructions influence sentence intelligibility. Method: Twelve speakers produced sentences in habitual, clear, hearing impaired, and overenunciate conditions. Stimuli were amplitude normalized and mixed with multitalker babble for orthographic transcription by 40 listeners. The main analysis…

  3. Impact of efalizumab on patient-reported outcomes in high-need psoriasis patients: results of the international, randomized, placebo-controlled Phase III Clinical Experience Acquired with Raptiva (CLEAR trial [NCT00256139

    Directory of Open Access Journals (Sweden)

    Shumack Stephen

    2005-12-01

    Full Text Available Abstract Background Chronic psoriasis can negatively affect patients' lives. Assessing the impact of treatment on different aspects of a patient's health-related quality of life (HRQOL is therefore important and relevant in trials of anti-psoriasis agents. The recombinant humanized IgG1 monoclonal antibody efalizumab targets multiple T-cell-dependent steps in the immunopathogenesis of psoriasis. Efalizumab has demonstrated safety and efficacy in several clinical trials, and improves patients' quality of life. Objective: To evaluate the impact of efalizumab on HRQOL and other patient-reported outcomes in patients with moderate to severe plaque psoriasis, including a large cohort of High-Need patients for whom at least 2 other systemic therapies were unsuitable because of lack of efficacy, intolerance, or contraindication. Methods A total of 793 patients were randomized in a 2:1 ratio to receive efalizumab 1 mg/kg/wk (n = 529 or placebo (n = 264 for 12 weeks. The study population included 526 High-Need patients (342 efalizumab, 184 placebo. The treatment was evaluated by patients using the HRQOL assessment tools Short Form-36 (SF-36 and Dermatology Life Quality Index (DLQI. Other patient-reported assessments included the Psoriasis Symptom Assessment (PSA, a visual analog scale (VAS for itching, and the Patient's Global Psoriasis Assessment (PGPA. Results Efalizumab was associated with improvements at Week 12 from baseline in patient-reported outcomes, both in the total study population and in the High-Need cohort. Among all efalizumab-treated patients, the DLQI improved by 5.7 points from baseline to Week 12, relative to an improvement of 2.3 points for placebo patients (P P Conclusion A 12-week course of efalizumab improved HRQOL and other patient-reported outcomes in patients with moderate to severe plaque psoriasis. The benefits of efalizumab therapy in High-Need patients were similar to those observed in the total study population, indicating

  4. SNOW CLEARING SERVICE WINTER 2001-2002

    CERN Multimedia

    ST-HM Group; Tel. 72202

    2001-01-01

    As usual at this time of the year, the snowing clearing service, which comes under the control of the Transport Group (ST-HM), is preparing for the start of snow-clearing operations (timetable, stand-by service, personnel responsible for driving vehicles and machines, preparation of useful and necessary equipment, work instructions, etc.) in collaboration with the Cleaning Service (ST-TFM) and the Fire Brigade (TIS-FB). The main difficulty for the snow-clearing service is the car parks, which cannot be properly cleared because of the presence of CERN and private vehicles parked there overnight in different parts of the parking areas. The ST-HM Transport Group would therefore like to invite you to park vehicles together in order to facilitate the access of the snow ploughs, thus allowing the car parks to be cleared more efficiently before the personnel arrives for work in the mornings.

  5. 养阴润肠方治疗慢性传输型便秘32例%Therapeutic Efficacy of Yin-nourishing and Intestine-clearing Prescription in Treatment of Slow Transit Constipation: A Report of 32 Cases

    Institute of Scientific and Technical Information of China (English)

    吴本升; 陈玉根; 吴霜; 侯孝涛

    2012-01-01

    Objective To observe the therapeutic efficacy of yin-nourishing and intestine-clearing prescription (YNICP) in the treatment of slow transit constipation (STC). Methods A total of 32 STC patients were treated with YNICP for 3 treatment courses (each course was 7 d). The therapeutic efficacies were assessed based on the scores of Patient Assessment of Constipation Quality of Life (PAC-QOL) questionnaire and Cleveland Clinic Constipation Scoring (CCCS) system before treatment, after 2 and 3 treatment courses, and one month after drug withdrawal. Results Of 32 patients, 17 were cured, 8 showed marked response, 4 showed response, and 3 showed no response, with an overall response rate of 90. 6%. The PAC-QOL questionnaire revealed that the patients had significantly decreased scores on physiological condition, anxiety, and satisfaction and total scores after 2 and 3 treatment courses and one month after drug withdrawal (P<0. 01) and significantly decreased scores on psychological state after 3 treatment courses and one month after drug withdrawal (P<0. 01). The CCCS system showed that the patients had significantly decreased scores after 2 and 3 treatment courses and one month after drug withdrawal (P<0. 01). Conclusion YNICP can effectively adjust the whole physical condition and improve the quality of life in the treatment of STC.%目的 观察养阴润肠方治疗慢性传输型便秘临床疗效.方法 符合纳入标准的32例慢性传输型便秘患者,使用养阴润肠方治疗3个疗程,每个疗程7 d,分别记录治疗前、2个疗程后、3个疗程后、停药1个月后便秘患者生活质量自评量表(patient assessment of constipation quality of life questionnaire,PAC-QOL)评分及Cleveland便秘评分.结果 治疗结束时治愈17例,显效8例,有效4例,无效3例,总有效率为90.6%.治疗前后PAC-QOL比较,在治疗2个疗程后、3个疗程后、停药1个月后,生理积分、担忧度积分、满意度积分、总分均显著减少(P<0

  6. Breast cancer survivors` recollection of their quality of life: Identifying determinants of recall bias in a longitudinal population-based trial.

    Science.gov (United States)

    Lindberg, Patricia; Netter, Petra; Koller, Michael; Steinger, Brunhilde; Klinkhammer-Schalke, Monika

    2017-01-01

    The recollections of survivors of breast cancer are an important source of information about the disease for their family, friends, and newly diagnosed patients. So far, little is known about these memories. This study investigated how accurately survivors of breast cancer remember their past quality of life (QoL) during the disease and if this memory is modified by women`s present QoL and negative affect. The longitudinal population-based study included 133 survivors of breast cancer (response rate 80%). Participants were asked for their present QoL and to recall their baseline QoL (EORTC QLQ-C30, QLQ-BR23) that had been assessed about seven years ago before discharge from hospital. The dependent variable was recall bias in ten QoL dimensions. Present QoL and negative affect (PANAS) were investigated as predictor variables. Overall, baseline QoL was retrospectively underrated on seven out of ten scales whereas no significant overestimation was found. In multiple linear regression analyses, controlling for confounders, a stronger underrating of QoL was significantly predicted by a lower present QoL on nine out of ten scales and by higher negative affect on six scales. Survivors of breast cancer tend to underestimate their past QoL during the disease when asked about seven years later. Lower present QoL and higher negative affect contribute to this recall bias. This needs to be considered when interpreting retrospectively reported QoL data. Results are discussed in relation to theory of change or stability and mood congruency theory.

  7. High Altitude Clear Air Turbulence Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Air Force Flight Dynamics Laboratory conducted the High Altitude Clear Air Turbulence Project in the mid 1960s with the intention of better understanding air...

  8. CO2 efflux from cleared mangrove peat.

    Directory of Open Access Journals (Sweden)

    Catherine E Lovelock

    Full Text Available BACKGROUND: CO(2 emissions from cleared mangrove areas may be substantial, increasing the costs of continued losses of these ecosystems, particularly in mangroves that have highly organic soils. METHODOLOGY/PRINCIPAL FINDINGS: We measured CO(2 efflux from mangrove soils that had been cleared for up to 20 years on the islands of Twin Cays, Belize. We also disturbed these cleared peat soils to assess what disturbance of soils after clearing may have on CO(2 efflux. CO(2 efflux from soils declines from time of clearing from ∼10,600 tonnes km(-2 year(-1 in the first year to 3000 tonnes km(2 year(-1 after 20 years since clearing. Disturbing peat leads to short term increases in CO(2 efflux (27 umol m(-2 s(-1, but this had returned to baseline levels within 2 days. CONCLUSIONS/SIGNIFICANCE: Deforesting mangroves that grow on peat soils results in CO(2 emissions that are comparable to rates estimated for peat collapse in other tropical ecosystems. Preventing deforestation presents an opportunity for countries to benefit from carbon payments for preservation of threatened carbon stocks.

  9. 76 FR 16587 - Risk Management Requirements for Derivatives Clearing Organizations

    Science.gov (United States)

    2011-03-24

    ... COMMISSION 17 CFR Part 39 RIN 3038-AC98 Risk Management Requirements for Derivatives Clearing Organizations... Principle D (Risk Management) and would establish a related reporting requirement under Core Principle J... Exchange Act (CEA) \\4\\ to establish a comprehensive regulatory framework to reduce risk,...

  10. 75 FR 77576 - General Regulations and Derivatives Clearing Organizations

    Science.gov (United States)

    2010-12-13

    ... Flexibility Act B. Paperwork Reduction Act 1. Information Provided by Reporting Entities/Persons 2...). \\6\\ See 17 CFR part 39, app. A. \\7\\ See 7 U.S.C. 7a-1(c)(2). Section 8a(5) of the CEA authorizes the... procedures,'' ``key personnel,'' ``stress test,'' and ``systemically important derivatives clearing...

  11. Multifocal Rhizopus microsporus lung infection following brush clearing

    Directory of Open Access Journals (Sweden)

    Artsiom V. Tsyrkunou

    2014-10-01

    Full Text Available We report a case of pulmonary Rhizopus microsporus infection in a patient with untreated diabetes following brush clearing. The patient was successfully treated with a combined medical and surgical approach with complete resolution of the lung lesions and remains asymptomatic at 11-month follow-up.

  12. Global horizontal irradiance clear sky models : implementation and analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Stein, Joshua S.; Hansen, Clifford W.; Reno, Matthew J.

    2012-03-01

    Clear sky models estimate the terrestrial solar radiation under a cloudless sky as a function of the solar elevation angle, site altitude, aerosol concentration, water vapor, and various atmospheric conditions. This report provides an overview of a number of global horizontal irradiance (GHI) clear sky models from very simple to complex. Validation of clear-sky models requires comparison of model results to measured irradiance during clear-sky periods. To facilitate validation, we present a new algorithm for automatically identifying clear-sky periods in a time series of GHI measurements. We evaluate the performance of selected clear-sky models using measured data from 30 different sites, totaling about 300 site-years of data. We analyze the variation of these errors across time and location. In terms of error averaged over all locations and times, we found that complex models that correctly account for all the atmospheric parameters are slightly more accurate than other models, but, primarily at low elevations, comparable accuracy can be obtained from some simpler models. However, simpler models often exhibit errors that vary with time of day and season, whereas the errors for complex models vary less over time.

  13. Evaluation of Clear Sky Models for Satellite-Based Irradiance Estimates

    Energy Technology Data Exchange (ETDEWEB)

    Sengupta, M.; Gotseff, P.

    2013-12-01

    This report describes an intercomparison of three popular broadband clear sky solar irradiance model results with measured data, as well as satellite-based model clear sky results compared to measured clear sky data. The authors conclude that one of the popular clear sky models (the Bird clear sky model developed by Richard Bird and Roland Hulstrom) could serve as a more accurate replacement for current satellite-model clear sky estimations. Additionally, the analysis of the model results with respect to model input parameters indicates that rather than climatological, annual, or monthly mean input data, higher-time-resolution input parameters improve the general clear sky model performance.

  14. Shanghai Clearing House to Roll out Renminbi-denominated Copper Clearing Operations in Free Trade Zone

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>Clearing House Financial Markets Co.,Ltd.(Shanghai Clearing House)General Manager Xie Zhong told the media recently at the briefing of the international symposium of"Reform Deepening and Mechanism Innovation of the Post-crisis Kerb Market",Shanghai Clearing House will explore the feasibility of carrying out bond business in

  15. Clear cell carcinoma of the female genital tract (not everything is as clear as it seems).

    Science.gov (United States)

    Offman, Saul L; Longacre, Teri A

    2012-09-01

    Clear cell carcinoma has a storied history in the female genital tract. From the initial designation of ovarian clear cell adenocarcinoma as "mesonephroma" to the linkage between vaginal clear cell carcinoma and diethylstilbestrol exposure in utero, gynecologic tract clear cell tumors have puzzled investigators, posed therapeutic dilemmas for oncologists, and otherwise presented major differential diagnostic challenges for pathologists. One of the most common errors in gynecologic pathology is misdiagnosis of clear cell carcinoma, on both frozen section and permanent section. Given the poor response to platinum-based chemotherapy for advanced-stage disease and increased risk of thromboembolism, accurate diagnosis of clear cell carcinoma is important in the female genital tract. This review (1) presents the clinical and pathologic features of female genital tract clear cell carcinomas; (2) highlights recent molecular developments; (3) identifies areas of potential diagnostic confusion; and (4) presents solutions for these diagnostic problems where they exist.

  16. Clear cell odontogenic carcinoma of maxilla: A diagnostic challenge

    Directory of Open Access Journals (Sweden)

    Fouzia Siraj

    2016-01-01

    Full Text Available Clear cell odontogenic carcinoma (CCOC is a rare odontogenic tumor which occurs mostly in the mandible. It is primarily seen in fifth to seventh decades with a female predilection. We report a case of CCOC in the maxillary arch of a 66-year-old woman. Morphologic examination along with histochemical and immunohistochemical markers led to the establishment of the diagnosis. It is important to diagnose this entity and differentiate it from other clear cell tumors in the head and neck region as it is a locally aggressive tumor with a propensity for regional, nodal, and distant metastasis.

  17. Acoustic characteristics of clearly spoken English fricatives.

    Science.gov (United States)

    Maniwa, Kazumi; Jongman, Allard; Wade, Travis

    2009-06-01

    Speakers can adopt a speaking style that allows them to be understood more easily in difficult communication situations, but few studies have examined the acoustic properties of clearly produced consonants in detail. This study attempts to characterize the adaptations in the clear production of American English fricatives in a carefully controlled range of communication situations. Ten female and ten male talkers produced fricatives in vowel-fricative-vowel contexts in both a conversational and a clear style that was elicited by means of simulated recognition errors in feedback received from an interactive computer program. Acoustic measurements were taken for spectral, amplitudinal, and temporal properties known to influence fricative recognition. Results illustrate that (1) there were consistent overall style effects, several of which (consonant duration, spectral peak frequency, and spectral moments) were consistent with previous findings and a few (notably consonant-to-vowel intensity ratio) of which were not; (2) specific acoustic modifications in clear productions of fricatives were influenced by the nature of the recognition errors that prompted the productions and were consistent with efforts to emphasize potentially misperceived contrasts both within the English fricative inventory and based on feedback from the simulated listener; and (3) talkers differed widely in the types and magnitude of all modifications.

  18. Hardwood Sprout Development on Cleared Sites

    Science.gov (United States)

    Frank W. Woods; John T. Cassady; Charles X Grano; Robert L. Johnson

    1961-01-01

    Clearing forest land of undesirable vegetation, with a view to obtaining desirable trees, is becoming increasingly common in the South. Bulldozers and other heavy equipment are generally used in such efforts. Success is measured largely by the degree to which recovery of the unwanted plants is prevented or slowed. This Occasional Paper contains three articles on the...

  19. Clearing and settlement of exchange traded derivatives

    OpenAIRE

    John McPartland

    2009-01-01

    Derivatives are a class of financial instruments that derive their value from some underlying commodity, security, index, or other asset. Futures and options are common forms of derivatives. This article explains how clearing and settlement systems for exchange traded derivatives work.

  20. Plant Histology: Clearing and the Optical Section.

    Science.gov (United States)

    Freeman, H. E.

    1985-01-01

    Clearing is a simple and rapid technique in which 75 percent lactic acid is used to remove pigments and cytoplasmic contents of fresh leaves, enabling microscopic view of various internal leaf layers. Procedures for using the technique (which helps students gain a more thorough understanding of plant anatomy) are given. (DH)

  1. Odontogenic ghost cell tumour with clear cell components: clear cell odontogenic ghost cell tumour?

    Science.gov (United States)

    Yoon, Jung Hoon; Ahn, Sang Gun; Kim, Su Gwan; Kim, Jin

    2004-07-01

    A case of odontogenic ghost cell tumour (OGCT) with clear cell components was encountered in the mandible of a 63-year-old man. The tumour revealed ameloblastomatous-type epithelial components accompanied by clusters of ghost cells and dentinoid juxtaposed to the odontogenic epithelium. In addition, some areas of the tumour tissue showed sheets and islands of clear, glycogen containing epithelial cells, which were separated by a thin fibrous connective tissue stroma. Both ameloblastic and clear cells exhibited positive immunoreactivities for cytokeratin 19 and AE1/3. It is not known whether this tumour represents a clear cell change of a pre-existing OGCT or a separate and distinct neoplasm derived de novo from the odontogenic epithelium. This tumour was given the term 'clear cell OGCT' because it captures the clear cell components, which is one of the most prominent distinguishing features of the tumour.

  2. Perceived gender in clear and conversational speech

    Science.gov (United States)

    Booz, Jaime A.

    Although many studies have examined acoustic and sociolinguistic differences between male and female speech, the relationship between talker speaking style and perceived gender has not yet been explored. The present study attempts to determine whether clear speech, a style adopted by talkers who perceive some barrier to effective communication, shifts perceptions of femininity for male and female talkers. Much of our understanding of gender perception in voice and speech is based on sustained vowels or single words, eliminating temporal, prosodic, and articulatory cues available in more naturalistic, connected speech. Thus, clear and conversational sentence stimuli, selected from the 41 talkers of the Ferguson Clear Speech Database (Ferguson, 2004) were presented to 17 normal-hearing listeners, aged 18 to 30. They rated the talkers' gender using a visual analog scale with "masculine" and "feminine" endpoints. This response method was chosen to account for within-category shifts of gender perception by allowing nonbinary responses. Mixed-effects regression analysis of listener responses revealed a small but significant effect of speaking style, and this effect was larger for male talkers than female talkers. Because of the high degree of talker variability observed for talker gender, acoustic analyses of these sentences were undertaken to determine the relationship between acoustic changes in clear and conversational speech and perceived femininity. Results of these analyses showed that mean fundamental frequency (fo) and f o standard deviation were significantly correlated to perceived gender for both male and female talkers, and vowel space was significantly correlated only for male talkers. Speaking rate and breathiness measures (CPPS) were not significantly related for either group. Outcomes of this study indicate that adopting a clear speaking style is correlated with increases in perceived femininity. Although the increase was small, some changes associated

  3. Cellulose Degradation by Cellulose-Clearing and Non-Cellulose-Clearing Brown-Rot Fungi

    OpenAIRE

    Highley, Terry L.

    1980-01-01

    Cellulose degradation by four cellulose-clearing brown-rot fungi in the Coniophoraceae—Coniophora prasinoides, C. puteana, Leucogyrophana arizonica, and L. olivascens—is compared with that of a non-cellulose-clearing brown-rot fungus, Poria placenta. The cellulose- and the non-cellulose-clearing brown-rot fungi apparently employ similar mechanisms to depolymerize cellulose; most likely a nonenzymatic mechanism is involved.

  4. Roadmap-Based Level Clearing of Buildings

    KAUST Repository

    Rodriguez, Samuel

    2011-01-01

    In this paper we describe a roadmap-based approach for a multi-agent search strategy to clear a building or multi-story environment. This approach utilizes an encoding of the environment in the form of a graph (roadmap) that is used to encode feasible paths through the environment. The roadmap is partitioned into regions, e.g., one per level, and we design region-based search strategies to cover and clear the environment. We can provide certain guarantees within this roadmap-based framework on coverage and the number of agents needed. Our approach can handle complex and realistic environments where many approaches are restricted to simple 2D environments. © 2011 Springer-Verlag.

  5. CLEARING MAGNET DESIGN FOR APS-U

    Energy Technology Data Exchange (ETDEWEB)

    Abliz, M.; Grimmer, J.; Jaski, Y.; Westferro, F.; Ramanathan, M.

    2017-06-25

    The Advanced Photon Source is in the process of developing an upgrade (APS-U) of the storage ring. The upgrade will be converting the current double bend achromat (DBA) lattice to a multi-bend achromat (MBA) lattice. In addition, the storage ring will be operated at 6 GeV and 200 mA with regular swap-out injection to keep the stored beam current constant [1]. The swap-out injection will take place with beamline shutters open. For radiation safety to ensure that no electrons can exit the storage ring, a passive method of protecting the beamline and containing the electrons inside the storage ring is proposed. A clearing magnet will be located in all beamline front ends inside the storage ring tunnel. This article will discuss the features and design of the clearing magnet scheme for APS-U.

  6. Internet compromise clears way for WSIS agreement

    CERN Multimedia

    Ermert, M

    2003-01-01

    A working group under the leadership of United Nations Secretary General Kofi Annan himself will try to resolve the deep differences on the question of Internet governance, officials said here. The group, whose exact membership wasn't immediately clear, is to propose a solution to the controversial issue that has given negotiators at the World Summit of the Information Society (WSIS) a headache (1/2 page).

  7. Optical clearing of muscle with propylene glycol

    Science.gov (United States)

    Oliveira, Luís; Lage, Armindo; Clemente, Manuel Pais; Tuchin, Valery V.

    2010-02-01

    Skeletal muscle presents an internal fibrous structure. The existence of muscle fibers surrounded by interstitial fluid originates an internal step refractive index profile that causes light scattering. One way to minimize this effect inside a muscle is to perform an optical clearing treatment, using an adequate solution that presents a refractive index higher than the interstitial fluid. We have studied muscle spectral transmittance during sample immersion in propylene glycol. With the collection of transmittance spectra registered during a period of 20 minutes of immersion we could represent spectral transmittance evolution for several wavelengths and verify that the tissue samples have become more translucent. The optical clearing effect created in the tissue samples was characterized by an increase of 45% above the natural transmittance and the variations observed in tissue mass, pH and global refractive index. We also identified the initial mechanisms of agent diffusion into the tissue and consequent tissue dehydration from the spectral transmittance evolution. The histological analysis of variations caused in the internal structure of the tissues permitted to better explain the optical clearing effect created. Considering a mathematical model developed in previous studies, we could estimate the amount of agent that was inserted into the tissue samples.

  8. Clear-cell variant of calcifying epithelial odontogenic tumor (Pindborg tumor) in the mandible

    Institute of Scientific and Technical Information of China (English)

    Ching-Yi Chen; Chung-Wei Wu; Wen-Chen Wang; Li-Min Lin; Yuk-Kwan Chen

    2013-01-01

    We present an uncommon case (female patient aged 59 years) of the clear-cell variant of calcifying epithelial odontogenic tumor (CEOT) (also known as Pindborg tumor) in the mandible. The clinical characteristics and probable origins of the clear tumor cells of previously reported cases of clear-cell variant of intraosseous CEOT are also summarized and discussed.

  9. The Nordic power market: Are there alternatives to expensive clearing?; Alternativer til kostbar clearing?

    Energy Technology Data Exchange (ETDEWEB)

    Nerdrum, Per Kaare; Poulsson, Christian

    2003-07-01

    The Enron scandal of 2002 has set focus on counter party risk in the Nordic power market and is an important cause of increased clearing of bilateral financial power contracts. The article discusses whether expensive clearing is always the best tool for dealing with counter party risk.

  10. CHINA'S WORST OIL LEAK CLEARED EXPENSIVELY

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Eight days and nights of clean-up efforts after the worst oil leak ever in Chinese waters, the aftermath of a collision between two foreign ships happening at 9:35 pm on December 7 about 8 nautical miles away from the mouth of the Pearl River and near the Danjiang Island, have finally paid off. So far, hundreds of tons of waste oil and polluted water have been cleared up. A large area of oil spills has been cleaned thanks to the prompt and proper operation launched just two hours after the accident.

  11. A gap clearing kicker for Main Injector

    CERN Document Server

    Kourbanis, I; Biggs, J; Brown, B; Capista, D; Jensen, C C; Krafczyk, G E; Morris, D K; Scott, D; Seiya, K; Ward, S R; Wu, G; Yang, M -J

    2012-01-01

    Fermilab Main Injector has been operating at high Beam Power levels since 2008 when multi-batch slip stacking became operational. In order to maintain and increase the beam power levels the localized beam loss due to beam left over in the injection kicker gap during slip stacking needs to be addressed. A set of gap clearing kickers that kick any beam left in the injection gap to the beam abort have been built. The kickers were installed in the summer of 2009 and became operational in November of 2010. The kicker performance and its effect on the beam losses will be described.

  12. Incidentally detected clear cell renal cell carcinoma with rhabdoid differentiation

    Directory of Open Access Journals (Sweden)

    Venkatesh Krishnamoorthy

    2016-01-01

    Full Text Available Renal cell carcinoma with rhabdoid differentiation (RCC-R has an aggressive biologic behavior and poor prognosis. A recent consensus statement of the International Society of Urological Pathology (ISUP proposed a nucleolar grading system (ISUP grade for RCC to replace Fuhrman system and recommended reporting the presence of rhabdoid differentiation and considering tumors with rhabdoid differentiation to be ISUP Grade 4. We report a case of incidentally detected clear cell RCC-R in a 52-year-old man. This is one of the earliest cases of RCC-R (pT1b detected and first such case from Indian subcontinent.

  13. Cerebellar clear cell ependymoma in a 10 year old girl

    Energy Technology Data Exchange (ETDEWEB)

    Thinzar Aye Nyein; Moon, Ah Rim; Hwang, Sun Chul; Hong, Hyun Sook; Lee, A Leum; Chang, Kee Hyun; Kim, Hee Kyung; Chin, Su Sie [Soonchunhyang University Bucheon Hospital, Bucheon (Korea, Republic of); Park, Ji Sang [Soonchunhyang University Gumi Hospital, Gumi (Korea, Republic of)

    2016-01-15

    Clear cell ependymoma (CCE) is a histological rare variant (1–5%) of ependymoma, which is distinguished from other histological subtypes by the presence of fusiform cells arrayed radially around small blood vessels. These alleged perivascular pseudorosettes are significant characteristic features of ependymomas. About 95% of infratentorial ependymomas are found in the fourth ventricle and the remainder occurs as cerebellopontine angle lesions. In previous reports, the cerebellum is found to be a rare location for ependymoma. In this study we report one case of CCE originating from the cerebellar hemisphere, showing unusual morphology on 3T MRI.

  14. Incidentally detected clear cell renal cell carcinoma with rhabdoid differentiation.

    Science.gov (United States)

    Krishnamoorthy, Venkatesh; Gowda, Kiran Krishne; Rao, Raman Narayana

    2016-01-01

    Renal cell carcinoma with rhabdoid differentiation (RCC-R) has an aggressive biologic behavior and poor prognosis. A recent consensus statement of the International Society of Urological Pathology (ISUP) proposed a nucleolar grading system (ISUP grade) for RCC to replace Fuhrman system and recommended reporting the presence of rhabdoid differentiation and considering tumors with rhabdoid differentiation to be ISUP Grade 4. We report a case of incidentally detected clear cell RCC-R in a 52-year-old man. This is one of the earliest cases of RCC-R (pT1b) detected and first such case from Indian subcontinent.

  15. The PLUTO experiment at DORIS (DESY) and the discovery of the gluon (A recollection)

    Energy Technology Data Exchange (ETDEWEB)

    Stella, Bruno R. [Rome-3 Univ. (Italy). Dipt. di Fisica; Istituto Nazionale di Fisica Nucleare, Rome (Italy); Meyer, Hans-Juergen

    2010-08-15

    With the aim of determining the contribution of the PLUTO experiment at the DORIS e{sup +}e{sup -} storage ring to the discovery of the gluon, as members of this former collaboration we have reconsidered all the scientific material produced by PLUTO in 1978 and the first half of 1979. It is clear that the experiment demonstrated the main decay of the Y(9.46 GeV) resonance to be mediated by 3 gluons, by providing evidence for the agreement of this hypothesis with average values and differential distributions of all possible experimental variables and by excluding all other possible alternative models. Moreover PLUTO measured in June 1979 the matrix element of the 3-gluon decay to be quantitatively as expected by QCD (even after hadronization) and, having checked the possibility to correctly trace the gluons' directions, demonstrated the spin 1 nature of the gluon by excluding spin 0 and spin 1/2. The hadronization of the gluon like a quark jet, hypothesized in the 3-gluon jet Monte Carlo simulation, was compatible with the topological data at this energy and was shown to be an approximation at 10% level for the multiplicity ({approx} < p {sub vertical} {sub stroke} {sub vertical} {sub stroke} {sub >}{sup -1}); the right expected gluon fragmentation was needed for the inclusive distributions; this was the first experimental study of (identified) gluon jets. In the following measurements at the PETRA storage ring, these results were confirmed by PLUTO and by three contemporaneous experiments by evidencing at higher energies the gluon radiation (''bremsstrahlung''), the softer one, by jet broadening, and the hard one, by the emission of (now clearly visible) gluon jets by quarks. The gluon's spin 1 particle nature was also confirmed. The PLUTO results on Y decays had been confirmed both by contemporaneous experiments at DORIS (partially) and later (also partially) were confirmed by more sophisticated detectors. (orig.)

  16. Comparative properties of optically clear epoxy encapsulants

    Science.gov (United States)

    Edwards, Maury; Zhou, Yan

    2001-12-01

    Three epoxy systems were evaluated for physical dn optical properties. The three systems chosen for the study were selected on the basis of their optical clarity, color and chemistry. Three distinctly different chemistries were chosen, aromatic epoxy-amine cured. Aromatic epoxy- anhydride cured and cycloaliphatic epoxy-anhydride cured. All three systems remained optically clear and water-white after full cure. The three selected systems were tested for physical properties, adhesion and light transmission properties. Light transmission was measured after thermal and humidity exposure. Adhesion was measured after humidity exposure only. Both of the epoxy-anhydride systems performed well in optical properties but poorer in adhesion as compared to the epoxy-amine system. The aromatic epoxy- amine system discolored badly during thermal exposure at 100 C. Data generated from this work will be used in selecting clear encapsulating materials for photonics applications. No single system offers optimal performance in all areas. The best compromise material is the aromatic epoxy-anhydride system.

  17. An unusual case of clear cell meningioma

    Directory of Open Access Journals (Sweden)

    Deb Prabal

    2009-01-01

    Full Text Available Clear-cell meningioma (CCM is an uncommon, aggressive variant of meningioma, usually affecting younger females and having predilection for infratentorial locations. We present a rare case of recurrent supratentorial CCM in a 58-year-old male. Ten years back, he had an intra-axial tumor in the left occipital lobe, which was managed by surgical excision and radiotherapy. Currently, the patient presented with sudden severe headache along with speech and vision disturbances. Neuroimaging revealed an extra-axial parietooccipital tumor, with intratumoural bleed. Histopathology of both tumors showed features of CCM, immunopositive for epithelial membrane antigen (EMA and vimentin. This case illustrates multiple unusual features of a rare variant of meningioma in the form of affection of an adult age group, supratentorial location, recurrence, and intratumoral bleed. It also highlights the importance of incorporating immunohistochemistry in the diagnostic workup, to exclude CCM mimics, each having distinctive biological behavior, and prognostic outcome, and warranting different therapeutic protocols.

  18. EBM, HTA, and CER: clearing the confusion.

    Science.gov (United States)

    Luce, Bryan R; Drummond, Michael; Jönsson, Bengt; Neumann, Peter J; Schwartz, J Sanford; Siebert, Uwe; Sullivan, Sean D

    2010-06-01

    The terms evidence-based medicine (EBM), health technology assessment (HTA), comparative effectiveness research (CER), and other related terms lack clarity and so could lead to miscommunication, confusion, and poor decision making. The objective of this article is to clarify their definitions and the relationships among key terms and concepts. This article used the relevant methods and policy literature as well as the websites of organizations engaged in evidence-based activities to develop a framework to explain the relationships among the terms EBM, HTA, and CER. This article proposes an organizing framework and presents a graphic demonstrating the differences and relationships among these terms and concepts. More specific terminology and concepts are necessary for an informed and clear public policy debate. They are even more important to inform decision making at all levels and to engender more accountability by the organizations and individuals responsible for these decisions.

  19. The PLUTO experiment at DORIS (DESY) and the discovery of the gluon (A Recollection)

    CERN Document Server

    Stella, Bruno R

    2010-01-01

    With the aim of determining the contribution of the PLUTO experiment at the DORIS e+e- storage ring to the discovery of the gluon, as members of this former collaboration we have reconsidered all the scientific material produced by PLUTO in 1978 and the first half of 1979. It is clear that the experiment demonstrated the main decay of the Y(9.46 GeV) resonance to be mediated by 3 gluons, by providing evidence for the agreement of this hypothesis with average values and differential distributions of all possible experimental variables and by excluding all other possible alternative models. Moreover PLUTO measured in June 1979 the matrix element of the 3-gluon decay to be quantitatively as expected by QCD (even after hadronization) and, having checked the possibility to correctly trace the gluons' directions, demonstrated the spin 1 nature of the gluon by excluding spin 0 and spin 1/2. The hadronization of the gluon like a quark jet, hypothesized in the 3-gluon jet Monte Carlo simulation, was compatible with th...

  20. Eye movements during the recollection of text information reflect content rather than the text itself

    DEFF Research Database (Denmark)

    Traub, Franziska; Johansson, Roger; Holmqvist, Kenneth

    Several studies have reported that spontaneous eye movements occur when visuospatial information is recalled from memory. Such gazes closely reflect the content and spatial relations from the original scene layout (e.g., Johansson et al., 2012). However, when someone has originally read a scene...

  1. Historical report of radiation protection at GEND

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    The information presented in this report was collected in response to a request by the GEND Plant Manager in November 1989. Included are a basic description of early operations, significant HP activities, unusual events, and a summary of environmental releases of radioactivity since plant start up in 1957. The bulk of this information was taken from microfilm records and personal recollection by John Holliday, GEND Health Physicist 1957 - 1985, under contract No. R-00162-X.

  2. MI Gap Clearing Kicker Magnet Design Review

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Chris; /Fermilab

    2008-10-01

    The kicker system requirements were originally conceived for the NOvA project. NOvA is a neutrino experiment located in Minnesota. To achieve the desired neutrino flux several upgrades are required to the accelerator complex. The Recycler will be used as a proton pre-injector for the Main Injector (MI). As the Recycler is the same size as the MI, it is possible to do a single turn fill ({approx}11 {micro}sec), minimizing the proton injection time in the MI cycle and maximizing the protons on target. The Recycler can then be filled with beam while the MI is ramping to extract beam to the target. To do this requires two new transfer lines. The existing Recycler injection line was designed for 10{pi} pbar beams, not the 20{pi} proton beams we anticipate from the Booster. The existing Recycler extraction line allows for proton injection through the MI, while we want direct injection from the Booster. These two lines will be decommissioned. The new injection line from the MI8 line into the Recycler will start at 848 and end with injection kickers at RR104. The new extraction line in the RR30 straight section will start with a new extraction kicker at RR232 and end with new MI injection kickers at MI308. Finally, to reduce beam loss activation in the enclosure, a new gap clearing kicker will be used to extract uncaptured beam created during the slip stack injection process down the existing dump line. It was suggested that the MI could benefit from this type of system immediately. This led to the early installation of the gap clearing system in the MI, followed by moving the system to Recycler during NOvA. The specifications also changed during this process. Initially the rise and fall time requirements were 38 ns and the field stability was {+-}1%. The 38 ns is based on having a gap of 2 RF buckets between injections. (There are 84 RF buckets that can be filled from the Booster for each injection, but 82 would be filled with beam. MI and Recycler contain 588 RF buckets

  3. Clear Channel Assessment in Integrated Medical Environments

    Directory of Open Access Journals (Sweden)

    Hara Shinsuke

    2008-01-01

    Full Text Available Abstract Complementary WLAN and WPAN technologies as well as other wireless technologies will play a fundamental role in the medical environments to support ubiquitous healthcare delivery. This paper investigates clear channel assessment (CCA and its impact on the coexistence of WLAN (IEEE 802.11 high rate direct sequence spread spectrum (HR/DSSS PHY and WPAN (IEEE 802.15.4b in the 2.4 GHz industrial, scientific, and medical (ISM band. We derived closed-form expressions of both energy-based CCA and feature-based CCA. We qualified unequal sensing abilities between them and termed this inequality asymmetric CCA, which is different from the traditional "hidden node" or "exposed node" issues in the homogeneous network. The energy-based CCA was considered in the considered integrated medical environment because the 2.4 GHz ISM band is too crowded to apply feature-based CCA. The WPAN is oversensitive to the 802.11 HR/DSSS signals and the WLAN is insensitive to the 802.15.4b signals. Choosing an optimal CCA threshold requires some prior knowledge of the underlying signals. In the integrated medical environment we considered here, energy-based CCA can effectively avoid possible packet collisions when they are close within the "heterogeneous exclusive CCA range" (HECR. However, when they are separated beyond the HECR, WPAN can still sense the 802.11 HR/DSSS signals, but WLAN loses its sense to the 802.15.4b signals. The asymmetric CCA leads to WPAN traffic in a position secondary to WLAN traffic.

  4. Clear Channel Assessment in Integrated Medical Environments

    Directory of Open Access Journals (Sweden)

    Bin Zhen

    2008-03-01

    Full Text Available Complementary WLAN and WPAN technologies as well as other wireless technologies will play a fundamental role in the medical environments to support ubiquitous healthcare delivery. This paper investigates clear channel assessment (CCA and its impact on the coexistence of WLAN (IEEE 802.11 high rate direct sequence spread spectrum (HR/DSSS PHY and WPAN (IEEE 802.15.4b in the 2.4 GHz industrial, scientific, and medical (ISM band. We derived closed-form expressions of both energy-based CCA and feature-based CCA. We qualified unequal sensing abilities between them and termed this inequality asymmetric CCA, which is different from the traditional “hidden node” or “exposed node” issues in the homogeneous network. The energy-based CCA was considered in the considered integrated medical environment because the 2.4 GHz ISM band is too crowded to apply feature-based CCA. The WPAN is oversensitive to the 802.11 HR/DSSS signals and the WLAN is insensitive to the 802.15.4b signals. Choosing an optimal CCA threshold requires some prior knowledge of the underlying signals. In the integrated medical environment we considered here, energy-based CCA can effectively avoid possible packet collisions when they are close within the “heterogeneous exclusive CCA range” (HECR. However, when they are separated beyond the HECR, WPAN can still sense the 802.11 HR/DSSS signals, but WLAN loses its sense to the 802.15.4b signals. The asymmetric CCA leads to WPAN traffic in a position secondary to WLAN traffic.

  5. Just a Collection of Recollections: Clinical Ethics Consultation and the Interplay of Evaluating Voices.

    Science.gov (United States)

    Bartlett, Virginia L; Bliton, Mark J; Finder, Stuart G

    2016-12-01

    Despite increased attention to the question of how best to evaluate clinical ethics consultations and emphasis on external evaluation (Hastings Center Report, ASBH Quality Attestation Process), there has been little sustained focus on how we, as clinicians, make sense of and learn from our own experiences in the midst of any one consultation. Questions of how we evaluate the request for, unfolding of, and conclusion of any specific ethics consultation are often overlooked, along with the underlying question of whether it is possible to give an accurate account of clinical ethics consultants' experience as experienced by ethics consultants. Before the challenge of submitting one's accounts or case reports for review and evaluation from others (at one's local institution or in the broader field), there is an underlying challenge of understanding and evaluating our own accounts. To highlight this crucial and deeply challenging dimension of actual clinical ethics practice, we present an account of a complex consultation, explicitly constructed to engage the reader in the unfolding experience of the consultant by emphasizing the multiple perspectives unfolding within the consultant's experience. Written in script format, the three perspectives presented-prototypical clinically descriptive account; didactically reflective and self-evidentiary account often seen in journal presentations; highly self-critical reflective account emphasizing uncertainties inherent to clinical ethics practice-reflect different manners for responding to the ways actual clinical involvement in ethics consultation practice accentuates and refocuses the question of how to understand and evaluate our own work, as well as that of our colleagues.

  6. Recollections of pressure to eat during childhood, but not picky eating, predict young adult eating behavior.

    Science.gov (United States)

    Ellis, Jordan M; Galloway, Amy T; Webb, Rose Mary; Martz, Denise M; Farrow, Claire V

    2016-02-01

    Picky eating is a childhood behavior that vexes many parents and is a symptom in the newer diagnosis of Avoidant/Restrictive Food Intake Disorder (ARFID) in adults. Pressure to eat, a parental controlling feeding practice aimed at encouraging a child to eat more, is associated with picky eating and a number of other childhood eating concerns. Low intuitive eating, an insensitivity to internal hunger and satiety cues, is also associated with a number of problem eating behaviors in adulthood. Whether picky eating and pressure to eat are predictive of young adult eating behavior is relatively unstudied. Current adult intuitive eating and disordered eating behaviors were self-reported by 170 college students, along with childhood picky eating and pressure through retrospective self- and parent reports. Hierarchical regression analyses revealed that childhood parental pressure to eat, but not picky eating, predicted intuitive eating and disordered eating symptoms in college students. These findings suggest that parental pressure in childhood is associated with problematic eating patterns in young adulthood. Additional research is needed to understand the extent to which parental pressure is a reaction to or perhaps compounds the development of problematic eating behavior.

  7. MODIS Collection 6 Clear Sky Restoral (CSR): Filtering Cloud Mast 'Not Clear' Pixels

    Science.gov (United States)

    Meyer, Kerry G.; Platnick, Steven Edward; Wind, Galina; Riedi, Jerome

    2014-01-01

    Correctly identifying cloudy pixels appropriate for the MOD06 cloud optical and microphysical property retrievals is accomplished in large part using results from the MOD35 1km cloud mask tests (note there are also two 250m subpixel cloud mask tests that can convert the 1km cloudy designations to clear sky). However, because MOD35 is by design clear sky conservative (i.e., it identifies "not clear" pixels), certain situations exist in which pixels identified by MOD35 as "cloudy" are nevertheless likely to be poor retrieval candidates. For instance, near the edge of clouds or within broken cloud fields, a given 1km MODIS field of view (FOV) may in fact only be partially cloudy. This can be problematic for the MOD06 retrievals because in these cases the assumptions of a completely overcast homogenous cloudy FOV and 1-dimensional plane-parallel radiative transfer no longer hold, and subsequent retrievals will be of low confidence. Furthermore, some pixels may be identified by MOD35 as "cloudy" for reasons other than the presence of clouds, such as scenes with thick smoke or lofted dust, and should therefore not be retrieved as clouds. With such situations in mind, a Clear Sky Restoral (CSR) algorithm was introduced in C5 that attempts to identify pixels expected to be poor retrieval candidates. Table 1 provides SDS locations for CSR and partly cloudy (PCL) pixels.

  8. Clear cell renal cell tumors: Not all that is "clear" is cancer.

    Science.gov (United States)

    Williamson, Sean R; Cheng, Liang

    2016-07-01

    Continued improvement of our understanding of the clinical, histologic, and genetic features of renal cell tumors has progressively evolved renal tumor classification, revealing an expanding array of distinct tumor types with different implications for prognosis, patient counseling, and treatment. Although clear cell renal cell carcinoma is unequivocally the most common adult renal tumor, there is growing evidence that some "clear cell" renal neoplasms, such as exemplified by multilocular cystic clear cell renal neoplasm of low malignant potential (formerly multilocular cystic renal cell carcinoma), do not have the same potential for insidious progression and metastasis, warranting reclassification as low malignant potential tumors or benign neoplasms. Still other novel tumor types such as clear cell papillary renal cell carcinoma have been more recently recognized, which similarly have shown a conspicuous absence of aggressive behavior to date, suggesting that these too may be recategorized as noncancerous or may be premalignant neoplasms. This importance for prognosis is increasingly significant in the modern era, in which renal masses are increasingly found incidentally by imaging techniques at a small tumor size, raising consideration for less aggressive management options guided by renal mass biopsy diagnosis, including imaging surveillance, tumor ablation, or partial nephrectomy.

  9. Halopeplis amplexicauis (Vahl Ung.-Sternb (Chenopodiaceae Family. Re-collection in Zarqa of Jordan

    Directory of Open Access Journals (Sweden)

    Fakher J. Aukour

    2013-06-01

    Full Text Available Halopeplis amplexicaulis is an annual halophytic species that is widespread in salty habitats throughout the countries of the Mediterranean. This species is a Naturalized exotic. In Jordan it was reported that this species was dominant in Wadi Araba, Wadi Rum, Eastern Desert, Shaumari and Al-Azraq Oasis, in the desert (saharo-arabian around the Dead Sea region, and Abar al Hazim. This species might be considered as invader one in such chorotype area, in that it is distributed in the Mediterranean Woodlands and Shrub lands, Deserts and extreme deserts. as the study area considered a dry habit, and on account of its special edaphic and water requirements, it is rare to see this species in such habitat.

  10. Revisiting optical clearing with dimethyl sulfoxide (DMSO)

    Science.gov (United States)

    Bui, Albert K.; McClure, R. Anthony; Chang, Jennell; Stoianovici, Charles; Hirshburg, Jason; Yeh, Alvin T.; Choi, Bernard

    2009-01-01

    Functional optical characterization of disease progression and response to therapy suffers from loss of spatial resolution and imaging depth due to scattering. Here we report on the ability of dimethyl sulfoxide (DMSO) alone to reduce the optical scattering of skin. We observed a three-fold reduction in the scattering of skin with topical DMSO application. With an in vivo window chamber model, we observed a three-fold increase in light transmittance through the preparation and enhanced visualization of subsurface microvasculature. Collectively, our data demonstrate the potential of DMSO alone to mitigate effects of scattering, which we expect will improve molecular imaging studies. PMID:19226579

  11. Reasons for Divorce and Recollections of Premarital Intervention: Implications for Improving Relationship Education.

    Science.gov (United States)

    Scott, Shelby B; Rhoades, Galena K; Stanley, Scott M; Allen, Elizabeth S; Markman, Howard J

    2013-06-01

    The study presents findings from interviews of 52 divorced individuals who received the Prevention and Relationship Enhancement Program (PREP) while engaged to be married. Using both quantitative and qualitative methods, the study sought to understand participant reasons for divorce (including identification of the "final straw") in order to understand if the program covered these topics effectively. Participants also provided suggestions based on their premarital education experiences so as to improve future relationship education efforts. The most commonly reported major contributors to divorce were lack of commitment, infidelity, and conflict/arguing. The most common "final straw" reasons were infidelity, domestic violence, and substance use. More participants blamed their partners than blamed themselves for the divorce. Recommendations from participants for the improvement of premarital education included receiving relationship education before making a commitment to marry (when it would be easier to break-up), having support for implementing skills outside of the educational setting, and increasing content about the stages of typical marital development. These results provide new insights into the timing and content of premarital and relationship education.

  12. Clear Cell Adenocarcinoma of the Urethra: Review of the Literature

    Directory of Open Access Journals (Sweden)

    Anthony Kodzo-Grey Venyo

    2015-01-01

    Full Text Available Background. Clear cell adenocarcinoma of the urethra (CCAU is extremely rare and a number of clinicians may be unfamiliar with its diagnosis and biological behaviour. Aims. To review the literature on CCAU. Methods. Various internet databases were used. Results/Literature Review. (i CCAU occurs in adults and in women in the great majority of cases. (ii It has a particular association with urethral diverticulum, which has been present in 56% of the patients; is indistinguishable from clear cell adenocarcinoma of the female genital tract but is not associated with endometriosis; and probably does not arise by malignant transformation of nephrogenic adenoma. (iii It is usually, readily distinguished from nephrogenic adenoma because of greater cytological a-typicality and mitotic activity and does not stain for prostate-specific antigen or prostatic acid phosphatase. (iv It has been treated by anterior exenteration in women and cystoprostatectomy in men and at times by radiotherapy; chemotherapy has rarely been given. (v CCAU is aggressive with low 5-year survival rates. (vi There is no consensus opinion of treatment options that would improve the prognosis. Conclusions. Few cases of CCAU have been reported. Urologists, gynaecologists, pathologists, and oncologists should report cases of CCAU they encounter and enter them into a multicentric trial to determine the best treatment options that would improve the prognosis.

  13. Medical Marijuana: Clearing Away the Smoke

    Science.gov (United States)

    Grant, Igor; Atkinson, J. Hampton; Gouaux, Ben; Wilsey, Barth

    2012-01-01

    Recent advances in understanding of the mode of action of tetrahydrocannabinol and related cannabinoid in-gredients of marijuana, plus the accumulating anecdotal reports on potential medical benefits have spurred increasing re-search into possible medicinal uses of cannabis. Recent clinical trials with smoked and vaporized marijuana, as well as other botanical extracts indicate the likelihood that the cannabinoids can be useful in the management of neuropathic pain, spasticity due to multiple sclerosis, and possibly other indications. As with all medications, benefits and risks need to be weighed in recommending cannabis to patients. We present an algorithm that may be useful to physicians in determining whether cannabis might be recommended as a treatment in jurisdictions where such use is permitted. PMID:22629287

  14. Differences in regeneration between hurricane damaged and clear-cut mangrove stands 25 years after clearing

    OpenAIRE

    Ferwerda, J.G.; Ketner, P.; McGuiness, K.A.

    2007-01-01

    The effect of human disturbance on mangrove forest may be substantially different from the effects of natural disturbances. This paper describes differences in vegetation composition and structure of five vegetation types in two mangrove areas near Darwin, Australia, 25 years after disturbance. The vegetation in clear-felled forest showed more adult Avicennia marina than in the hurricane-affected forest, and a virtual absence of A. marina juveniles and saplings. This indicates that A. marina ...

  15. The Dissociation of Recollection from Familiarity in the Condition of Conceptual-similarity%语义相似性下回忆和熟悉性的分离

    Institute of Scientific and Technical Information of China (English)

    王晓娜; 李琦; 郭春彦

    2011-01-01

    Results from cognitive, neuropsychological and neuroimaging studies of human memory indicate that recognition memory performance reflected two distinct memory processes: recollection and familiarity. Recollection involved the retrieval of specific details associated with something recognized; familiarity was an assessment of the overall similarity between a test item and all study-list information in memory. Previous ERP studies of the recollection and familiarity suggested that: during 300 500ms, FN400 ERP old new effect was related to familiarity, and during the 400- 800ms, the parietal ERP old new effect was related to recollection. However, this hypothes~s had not yet to be confirmed. The purpose of our studies was to explore the dissociation of recoUection from familiarity. Using Event-related Potentials, the present study adopted Chinese characters as stimuli. Subjects were seventeen undergraduate students in which three subjects were rejected because of lacking of the humor of superposition. The size of statistical sample was fourteen, in which there were eight girls and six boys. The average age of the sample was twenty point one years old. All the subjects were right-handed with normal vision or corrected visual acuity. All the subjects had no history of mental illness or history of brain diseases. We gave the certain degree of compensation to subjects after the experiment. This study adopted a "study-test" pattern and the material of Chinese characters to explore the dissociation of recollection from familiarity in condition of conceptual-similarity using event-related potential (ERPs) measurements. The task of the studying phase was to remember the words that appeared on the screen, but not pressing any key. There were three types of words in the testing stage including old words, similar words (conceptualsimilarity with old words) and new words (not conceptual-similarity with old words). The task of the testing phase was to make old

  16. CLEARS An Education and Research Tool for Computational Semantics

    CERN Document Server

    Milward, D; Maier, Hans J; Pinkal, M; Milward, David; Konrad, Karsten; Maier, Holger; Pinkal, Manfred

    1996-01-01

    The CLEARS (Computational Linguistics Education and Research for Semantics) tool provides a graphical interface allowing interactive construction of semantic representations in a variety of different formalisms, and using several construction methods. CLEARS was developed as part of the FraCaS project which was designed to encourage convergence between different semantic formalisms, such as Montague-Grammar, DRT, and Situation Semantics. The CLEARS system is freely available on the WWW from http://coli.uni-sb.de/~clears/clears.html

  17. Identifying fly puparia by clearing technique: application to forensic entomology.

    Science.gov (United States)

    Sukontason, Kabkaew L; Ngern-Klun, Radchadawan; Sripakdee, Duanghatai; Sukontason, Kom

    2007-10-01

    In forensic investigations, immature stages of the fly (egg, larva, or puparia) can be used as entomological evidence at death scenes, not only to estimate the postmortem interval (PMI), analyze toxic substances, and to determine the manner of death but also to indicate the movement of a corpse in homicide cases. Of these immature stages, puparia represent the longest developmental time, which makes them of useful. However, in order for forensic entomologists to use puparia effectively, it is crucial that they are able to accurately identify the species of fly found in a corpse. Typically, these puparia are similar in general appearance, being coarctate and light brown to dark brown in color, which makes identification difficult. In this study, we report on the clearing technique used to pale the integument of fly puparia, thereby allowing observation of the anterior end (second to fourth segments) and the profile of the posterior spiracle, which are important clues for identification. We used puparia of the blowfly, Chrysomya megacephala (F.), as the model species in this experiment. With placement in a 20% potassium hydroxide solution daily and mounting on a clearing medium (Permount(R), New Jersey), the profile of the posterior spiracle could be clearly examined under a light microscope beginning on the fifth day after pupation, and the number of papillae in the anterior spiracle could be counted easily starting from the ninth day. Comparison of morphological features of C. megacephala puparia with those of other blowflies (Chrysomya nigripes [Aubertin], Chrysomya rufifacies [Macquart], Chrysomya villeneuvi [Patton], Lucilia cuprina [Wiedemann], and Hemipyrellia ligurriens [Wiedemann]) and a housefly (Musca domestica L.) revealed that the anterior ends and the profiles of the posterior spiracles had markedly distinguishing characteristics. Morphometric analysis of the length and width of puparia, along with the length of the gaps between the posterior spiracles

  18. Recollections of David Marr.

    Science.gov (United States)

    Nishihara, H K

    2012-01-01

    David Marr came to MIT's Artificial Intelligence (AI) Lab in the early 1970s and energized the study of vision at the intersection of computer science, psychology, and neuroscience. As one of his first graduate students, I had the privilege of getting to know him and working with him during that heady period of AI research.

  19. Recollections of Stanley Mandelstam

    Science.gov (United States)

    Chew, Geoffrey

    2017-01-01

    This article is based upon the audio recording taken on September 9th 2016 by my children. I thank Chee Hok Lim for writing the first transcript in the World Scientific format and Ling-Lie Chau for comments and footnotes.

  20. 77 FR 66196 - Self-Regulatory Organizations; Options Clearing Corporation; Order Approving Proposed Rule Change...

    Science.gov (United States)

    2012-11-02

    ... JRFQR with ``Form 1'' of the International Financial Reporting Standards. OCC proposes to replace... Financial Reporting Standards. OCC Rule 310, through cross-references to interpretive provisions of OCC Rule... Relating to Financial Reporting by Canadian Clearing Members October 26, 2012. I. Introduction On...

  1. 77 FR 58194 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Proposed...

    Science.gov (United States)

    2012-09-19

    ..., through cross-references to interpretive provisions of OCC Rule 306--Financial Reports and OCC Rule 308... reporting of certain financial liabilities to U.S. Generally Accepted Accounting Principles. Canadian... Change Relating to Financial Reporting by Canadian Clearing Members September 13, 2012. Pursuant...

  2. Luminous efficacy of global solar radiation for clear skies

    Energy Technology Data Exchange (ETDEWEB)

    Robledo, L. [Universidad Politecnica de Madrid (Spain). Departamento de Sistemas Inteligentes Aplicados; Soler, A. [Universidad Politecnica de Madrid (Spain). Facultad de Ciencias Ambientales

    2000-11-01

    The luminous efficacy of global solar radiation for clear skies has been modeled using solar elevation as the only independent parameter. In the present work, two types of models are developed. On the one hand, polynomial models similar to those presented by other authors are produced, and on the other, a non-polynomial model for the luminous efficacy of global solar radiation is reported, as obtained from the ratio between the corresponding illuminance and irradiance models. This last mentioned model offers an accuracy to predict global illuminance similar to that obtained with the polynomial models. However, the model for the global efficacy obtained from illuminance and irradiance models has, among others, the advantage of its mathematical coherence, and its formulation uses a more definite function than the polynomial models. (author)

  3. Renal Clear Cell Sarcoma - Anaplastic Variant: A Rare Entity.

    Science.gov (United States)

    Walke, Vaishali Atmaram; Shende, Nitin Y; Kumbhalkar, D T

    2017-01-01

    Clear Cell Sarcoma of Kidney (CCSK) is known for its morphologic diversity, aggressive behaviour, tendency to recur and metastasis to bone. Amongst the various morphologic subtypes, anaplastic CCSK is associated with worse prognosis. Here, we report a case of this rare variant of CCSK. A five-year-old boy presented with history of lump and pain in abdomen since one week. The Computed Tomography (CT) scan revealed a large mass occupying the middle and inferior pole of right kidney. The clinical impression was Wilms tumour. Nephrectomy specimen was received and the diagnosis of CCSK anaplastic variant was offered only after excluding the differentials and after performing ancillary tests such as Immunohistochemistry (IHC). Thus, this case emphasizes the diagnostic challenges on morphology and the essential role of IHC in arriving at a definitive diagnosis, because failure to do so may deprive the child from optimal treatment.

  4. Clear cell chondrosarcoma mimicking chondroblastoma in a skeletally immature patient

    Energy Technology Data Exchange (ETDEWEB)

    Cannon, Christopher P. [Department of Orthopaedic Surgery, Madigan Army Medical Center, Ft. Lewis, WA (United States); Nelson, Scott D. [Department of Pathology and Laboratory Medicine, University of California, Los Angeles School of Medicine, CA (United States); Seeger, Leanne L. [Department of Radiological Sciences, University of California, CA (United States); Eckardt, Jeffrey J. [Department of Orthopaedic Surgery, University of California, Los Angeles School of Medicine, CA (United States)

    2002-06-01

    We report the case of a clear cell chondrosarcoma (CCCS) occurring in the femoral head of a 14-year-old skeletally immature boy. Radiographic examination revealed a well-defined, osteolytic lesion in the epiphysis of the femoral head. Given the patient's age and the radiographic appearance of the lesion, chondroblastoma was high on the differential diagnosis. A frozen section was performed at the time of open biopsy was felt to be consistent with either chondroblastoma or CCCS. CCCS in a skeletally immature patient was felt to be unlikely, so curettage and bone grafting was performed. Final pathology review, however, confirmed the diagnosis of CCCS. The patient was taken back to surgery 4 weeks later for a wide resection and hemiarthroplasty. (orig.)

  5. Solubility determination from clear points upon solvent addition

    NARCIS (Netherlands)

    Reus, M.A.; Heijden, A.E.D.M. van der; Horst, J.H. ter

    2015-01-01

    A method is described for determining the solubility of multicomponent crystalline compounds from clear points upon sample dilution at a constant temperature. Clear points are established by continuously adding a solvent mixture to a suspension of known composition until a clear solution appears. Fo

  6. Clear Cell Sarcoma of Gluteal Region Malignant Melanoma of Soft Parts

    Directory of Open Access Journals (Sweden)

    Haren V. Oza

    2013-04-01

    Full Text Available Clear cell sarcoma (CCS is described as variant of sarcoma characterized by prominent clear cells showing features similar to malignant melanoma of soft parts. This neoplasm was first described by Dr. Franz m. Enzinger. Primary CCS usually arises in deeper soft tissues, in association with fascia, tendons, or aponeuroses. Clear cell sarcoma (CCS is a rare malignant tumor with a propensity for slow progressive invasion. It is a tumor derived from Melanoblast like cell. They occur most commonly in the extremities, with a predilection for young females. Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts and conventional malignant melanoma may demonstrate significant morphologic overlap at the light microscopic and ultra structural level. The tumor is very rare and can pose clinical challenges in early diagnosis. This case report demonstrates an unusual site of occurrence for clear cell sarcoma. [Natl J Med Res 2013; 3(2.000: 193-195

  7. Global ballast water management and the "same location" concept: a clear term or a clear issue?

    Science.gov (United States)

    David, Matej; Gollasch, Stephan; Pavliha, Marko

    2013-03-01

    The United Nations recognized the transfer of harmful organisms and pathogens across natural barriers as one of the four greatest pressures to the world's oceans and seas, causing global environmental changes, while also posing a threat to human health, property, and resources. Ballast water transferred by vessels was recognized as a prominent vector of such species and was regulated by the International Convention for the Control and Management of Ship's Ballast Water and Sediments (2004). Permanent exceptions from ballast water management requirements may apply when the uptake and discharge of ballast water occur at the "same location." However, the "same location" concept may be interpreted differently, e.g., a port basin, a port, an anchorage, or a larger area even with more ports inside. Considering that the Convention is nearing the beginning of enforcement, national authorities all around the world will soon be exposed to applications for exceptions. Here we consider possible effects of different interpretations of the "same location" concept. We have considered different possible extensions of the same location through environmental, shipping, and legal aspects. The extension of such areas, and the inclusion of more ports, may compromise the Convention's main purpose. We recommend that "same location" mean the smallest practicable unit, i.e., the same harbor, mooring, or anchorage. An entire smaller port, possibly also including the anchorage, could be considered as same location. For larger ports with a gradient of environmental conditions, "same location" should mean a terminal or a port basin. We further recommend that IMO consider the preparation of a guidance document to include concepts, criteria, and processes outlining how to identify "same location," which limits should be clearly identified.

  8. Optimized optical clearing method for imaging central nervous system

    Science.gov (United States)

    Yu, Tingting; Qi, Yisong; Gong, Hui; Luo, Qingming; Zhu, Dan

    2015-03-01

    The development of various optical clearing methods provides a great potential for imaging entire central nervous system by combining with multiple-labelling and microscopic imaging techniques. These methods had made certain clearing contributions with respective weaknesses, including tissue deformation, fluorescence quenching, execution complexity and antibody penetration limitation that makes immunostaining of tissue blocks difficult. The passive clarity technique (PACT) bypasses those problems and clears the samples with simple implementation, excellent transparency with fine fluorescence retention, but the passive tissue clearing method needs too long time. In this study, we not only accelerate the clearing speed of brain blocks but also preserve GFP fluorescence well by screening an optimal clearing temperature. The selection of proper temperature will make PACT more applicable, which evidently broaden the application range of this method.

  9. Hemosiderotic clear-cell acanthoma: A pigmented mimicker

    Directory of Open Access Journals (Sweden)

    Leonardo Bugatti

    2011-01-01

    Full Text Available The authors report on a case of a 65-year-old man with pigmented clear-cell acanthoma located on the right thigh. Dermoscopy disclosed a peculiar picture consisting of diffuse black pigmentation with a superficial greyish veil in the central portion, dotted-to-globular dark red-black structures mainly located at the periphery with a homogenous regular reticular arrangement; peripheral translucid desquamation. Dermoscopic features are correlated with the histology, where hemosiderin deposits present in a sheet-like arrangement in the perivascular papillary dermis and in a band-like disposition in the reticular dermis at the base of the lesion can account for the pigmented picture. The lesion arose on a trauma-prone skin site; thus the authors believe that traumatic irritation may be responsible for the clinical and dermoscopic pictures, giving rise to a reaction similar in a way to the Auspitz′s sign provocated by trauma for psoriasis. Red blood cells extravasation from extremely superficialized capillaries may have led to hemosiderin deposition in the papillary and the reticular dermis.

  10. The Clearing: Heidegger’s Lichtung and The Big Scrub

    Directory of Open Access Journals (Sweden)

    Rob Garbutt

    2010-02-01

    Full Text Available Clearings make settlement possible. Whether on a small scale using an axe and other hand implements to make way for a dwelling and a garden, or on a large scale with a chain strung between two D9 bulldozers in preparation for a major agribusiness development, the process of clearing creates spaces for installing something new. This paper uses the idea of (the clearing, as practice, process, outcome and metaphor, to examine the installation of the locals in a settler society. Using Lismore on the far-north coast of New South Wales, Australia, as a case example, the particular work of clearing that is discussed here is a practice that enables a form of colonisation and settlement that distances itself from its history of migration. This is a history of settler locals who were 'always here', and a colonial form of clearing clears the land and the mind of troubling pasts and of troubling presences. For the locals within a place, then, clearing manages and simplifies a complex set of social and material relations, histories and identities. Using Anthony Appiah's concept the 'space clearing gesture', the paper concludes with a reflection on the space in which the idea of "the clearing" and this paper appears. Do places, in this instance rural places, provide a type of clearing in which certain ideas might appear that may not appear elsewhere? If situatedness matters then the diversity of places where thinking is done is important for our ecology of thought, and in connection with this, perhaps what 'rural cultural studies' does is clear a particular type of space for thinking.

  11. The Clearing : Heidegger’s Lichtung and the big scrub

    Directory of Open Access Journals (Sweden)

    Garbutt, Rob

    2010-01-01

    Full Text Available Clearings make settlement possible. Whether on a small scale using an axe and other hand implements to make way for a dwelling and a garden, or on a large scale with a chain strung between two D9 bulldozers in preparation for a major agribusiness development, the process of clearing creates spaces for installing something new. This paper uses the idea of (the clearing, as practice, process, outcome and metaphor, to examine the installation of the locals in a settler society. Using Lismore on the far-north coast of New South Wales, Australia, as a case example, the particular work of clearing that is discussed here is a practice that enables a form of colonisation and settlement that distances itself from its history of migration. This is a history of settler locals who were 'always here', and a colonial form of clearing clears the land and the mind of troubling pasts and of troubling presences. For the locals within a place, then, clearing manages and simplifies a complex set of social and material relations, histories and identities.Using Anthony Appiah's concept the 'space clearing gesture', the paper concludes with a reflection on the space in which the idea of "the clearing" and this paper appears. Do places, in this instance rural places, provide a type of clearing in which certain ideas might appear that may not appear elsewhere? If situatedness matters then the diversity of places where thinking is done is important for our ecology of thought, and in connection with this, perhaps what 'rural cultural studies' does is clear a particular type of space for thinking.

  12. A New Type of distributed Enamel based Clearing Electrode

    CERN Document Server

    Kroyer, T; Caspers, Friedhelm; Hellmond, P; Métral, E; Wendel, J C; Zimmermann, F

    2007-01-01

    Clearing electrodes can be used for electron cloud (EC) suppression in high intensity particle accelerators. In this paper the use of low and highly resistive layers on a dielectric substrate are examined. The beam coupling impedance of such a structure is evaluated. Furthermore the clearing efficiency as well as technological issues are discussed.

  13. 75 FR 63113 - Financial Resources Requirements for Derivatives Clearing Organizations

    Science.gov (United States)

    2010-10-14

    ... participants, thus contributing to the financial integrity of the futures and options markets as a whole. This... the derivatives clearing organization's rules; and (vi) Any other financial resource deemed acceptable...) may include: (i) The derivatives clearing organization's own capital; and (ii) Any other...

  14. Glycogen-rich clear cell carcinoma of the breast

    DEFF Research Database (Denmark)

    Sørensen, Flemming Brandt; Paulsen, S M

    1987-01-01

    The light microscopic, immunohistochemical and ultrastructural features of a clear cell carcinoma of the breast have been studied. Both intraductal and invasive components were found. Histochemistry showed large amounts of intracytoplasmic glycogen and sparse neutral mucin in the tumour. The tumo...... was classified as a mucin-containing variant of glycogen-rich, clear cell carcinoma of the breast....

  15. Behind the money market: clearing and settling money market instruments

    OpenAIRE

    David L. Mengle

    1992-01-01

    When a money market instrument is traded, the clearing and settlement process establishes the change in ownership. Because the process involves both costs and risks, money market participants have developed means of making clearing and settlement more efficient and less risky.

  16. 18 CFR 367.1840 - Account 184, Clearing accounts.

    Science.gov (United States)

    2010-04-01

    ... ACT Balance Sheet Chart of Accounts Deferred Debits § 367.1840 Account 184, Clearing accounts. This account must include undistributed balances in clearing accounts at the date of the balance sheet... accounts. 367.1840 Section 367.1840 Conservation of Power and Water Resources FEDERAL ENERGY...

  17. ClearPEM: prototype PET device dedicated to breast imaging

    CERN Multimedia

    Joao Varela

    2009-01-01

    Clinical trials have begun in Portugal on a new breast imaging system (ClearPEM) using positron emission tomography (PET). The system, developed by a Portuguese consortium in collaboration with CERN and laboratories participating in the Crystal Clear collaboration, will detect even the smallest tumours and thus help avoid unnecessary biopsies.

  18. The Effectiveness of Clear Speech as a Masker

    Science.gov (United States)

    Calandruccio, Lauren; Van Engen, Kristin; Dhar, Sumitrajit; Bradlow, Ann R.

    2010-01-01

    Purpose: It is established that speaking clearly is an effective means of enhancing intelligibility. Because any signal-processing scheme modeled after known acoustic-phonetic features of clear speech will likely affect both target and competing speech, it is important to understand how speech recognition is affected when a competing speech signal…

  19. 75 FR 78185 - Information Management Requirements for Derivatives Clearing Organizations

    Science.gov (United States)

    2010-12-15

    ... for information concerning all other DCOs (including clearing organizations registered as DCOs but... organization, including information relating to trade and clearing details, in the form and manner and within... COMMISSION 17 CFR Parts 1, 21, and 39 RIN 3038-AC98 Information Management Requirements for Derivatives...

  20. 76 FR 14471 - Clearing Agency Standards for Operation and Governance

    Science.gov (United States)

    2011-03-16

    ... Operation and Governance; Proposed Rule #0;#0;Federal Register / Vol. 76, No. 51 / Wednesday, March 16, 2011... Standards for Operation and Governance AGENCY: Securities and Exchange Commission. ACTION: Proposed rule... clearing agencies and standards for the operation and governance of clearing agencies. The proposed...

  1. A simple formula for determining globally clear skies

    Energy Technology Data Exchange (ETDEWEB)

    Long, C.N.; George, A.T.; Mace, G.G. [Penn State Univ., University Park, PA (United States)] [and others

    1996-04-01

    Surface measurements to serve as {open_quotes}ground truth{close_quotes} are of primary importance in the development of retrieval algorithms using satellite measurements to predict surface irradiance. The most basic algorithms of this type deal with clear sky (i.e., cloudless) top-to-surface shortwave (SW) transfer, serving as a necessary prerequisite towards treating both clear and cloudy conditions. Recently, atmosphere SW cloud forcing to infer the possibility of excess atmospheric absorption (compared with model results) in cloudy atmospheres. The surface component of this ratio relies on inferring the expected clear sky SW irradiance to determine the effects of clouds on the SW energy budget. Solar renewable energy applications make use of clear and cloud fraction climatologies to assess solar radiation resources. All of the above depend to some extent on the identification of globally clear sky conditions and the attendant measurements of downwelling SW irradiance.

  2. Clear cell hepatocellular carcinoma: Back to the basics for diagnosis

    Directory of Open Access Journals (Sweden)

    Puja Sakhuja

    2015-01-01

    Full Text Available Hepatocellular carcinoma (HCC is a common cancer world-wide with a higher incidence in Asia. Clear cell variant of HCC (CCHCC has a frequency ranging from 0.4% to 37%. The presence of 90-100% clear cells is rare. In the present case, a 35-year-old female patient presented with fever and a large abdominal mass in the right hypochondrium. Histology of the tumor revealed >95% clear cells and after taking multiple sections from different areas of tumor only few scattered cells with eosinophilic cytoplasm were found. Immunohistochemistry with Hep Par 1, Glypican 3 and polyclonal carcinoembryonic antigen were negative as were all other markers for metastatic clear cell tumors. Histological diagnosis was based on routine H and E sections showing a histological pattern of architecture with thickened trabeculae. We describe a rare case of CCHCC with >95% clear cells and no immunoreactivity in tumor cells in a non-cirrhotic liver.

  3. A study of metalized electrode self-clearing in electroactive polymer (EAP) based actuators

    Science.gov (United States)

    Ahmed, Saad; Ounaies, Zoubeida

    2016-04-01

    Electroactive polymer (EAP) based technologies have shown promise in areas such as artificial muscles, actuator, aerospace, medical and soft robotics. Still challenges remain such as low induced forces and defects-driven electrical breakdown, which impede the practical implementation of this technology. Multilayered or stacked configuration can address the low induced force issue whereas self-clearing can be a technique to improve breakdown limit of EAP based actuators. Self-clearing refers to the partial local breakdown of dielectric medium due to the presence of impurities, which in turn results in the evaporation of some of the metalized electrode. After this evaporation, the impurity is cleared and any current path would be safely cut off, which means the actuator continues to perform. It is a widely studied concept in the capacitor community, while it has not been studied much for EAP technologies. In this paper we report a systematic approach to precondition a silver-metalized electroactive polymer (EAP), more specifically P(VDF-TrFE-CTFE) terpolymer, using self-clearing concept. First, we show improvement in the dielectric breakdown strength of EAP based unimorph actuators after pre-clearing the impurities using low electric field (lower than dielectric breakdown of the terpolymer). Inspired by this improvement, we used Weibull statistics to systematically estimate the self-clearing/ preconditioning field needed to clear the defects. Then electrical breakdown experiments are conducted with and without preconditioning the samples to investigate its effect on the breakdown strength of the sample.

  4. Molecular basis for optical clearing of collagenous tissues

    Science.gov (United States)

    Hirshburg, Jason M.; Ravikumar, Krishnakumar M.; Hwang, Wonmuk; Yeh, Alvin T.

    2010-09-01

    Molecular interactions of optical clearing agents were investigated using a combination of molecular dynamics (MD) simulations and optical spectroscopy. For a series of sugar alcohols with low to high optical clearing potential, Raman spectroscopy and integrating sphere measurements were used to quantitatively characterize tissue water loss and reduction in light scattering following agent exposures. The rate of tissue water loss was found to correlate with agent optical clearing potential, but equivalent tissue optical clearing was measured in native and fixed tissue in vitro, given long-enough exposure times to the polyol series. MD simulations showed that the rate of tissue optical clearing correlated with the preferential formation of hydrogen bond bridges between agent and collagen. Hydrogen bond bridge formation disrupts the collagen hydration layer and facilitates replacement by a chemical agent to homogenize tissue refractive index. However, the reduction in tissue light scattering did not correlate with the agent index of refraction. Our results suggest that a necessary property of optical clearing agents is hyperosmolarity to tissue, but that the most effective agents with the highest rates of optical clearing are a subset with the highest collagen solubilities.

  5. One Clear Image? Challenging Simplicity in Place Branding

    DEFF Research Database (Denmark)

    Ren, Carina Bregnholm; Blichfeldt, Bodil Stilling

    2011-01-01

    Unique selling points! Simplicity sells! One clear identity! One clear image! These are some of the place branding mantras of today. In this paper, this “simplicity trend” is critically examined and challenged by raising the question whether clear images and simplicity are truly the only options...... in destination branding. After a short introduction and discussion of the underlying assumptions of destination branding strategy, an illustrative case is used to demonstrate how tourism stakeholders create several different “versions” of the tourist destination through a multiplicity of discursive, performative...

  6. Clear-PEM, a dedicated PET camera for mammography

    CERN Document Server

    Lecoq, P

    2002-01-01

    Preliminary results suggest that Positron Emission Mammography (PEM) can offer a noninvasive method for the diagnosis of breast cancer. Metabolic images from PEM contain unique information not available from conventional morphologic imaging techniques and aid in expeditiously establishing the diagnosis of cancer. A dedicated machine seems to offer better perspectives in terms of position resolution and sensitivity. This paper describes the concept of Clear-PEM, the system presently developed by the Crystal Clear Collaboration at CERN for an evaluation of this approach. This device is based on new crystals introduced by the Crystal Clear as well as on modern data acquisition techniques developed for the large experiments in high energy physics experiments.

  7. Clear cell sarcoma: A case mimicking primary cutaneous malignant melanoma

    Directory of Open Access Journals (Sweden)

    Rodriguez-Martin M

    2009-01-01

    Full Text Available Clear cell sarcoma (CCS is a recently described variant of sarcoma characterized by prominent clear cells showing features similar to clear cell melanoma. This neoplasm was first described by Dr. Franz M. Erzinger. Primary CCS usually arises in deeper soft tissues, in association with fascia, tendons, or aponeuroses. Characteristic translocation t(12;22 (q13;q12 has been considered pathognomonic for CCS. Prognosis is related to tumor size. An early recognition and initial radical surgery is the key to a favourable outcome. We present a patient with an unusual neoplasm that resembled malignant melanoma.

  8. Molecular Air Data Clear Air Turbulence Sensor: MADCAT Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Clear air turbulence (CAT), often referred to as "air pockets," is attributed to Kelvin-Helmholtz instabilities at altitudes generally above 18,000ft, often in the...

  9. CBFS: high performance feature selection algorithm based on feature clearness.

    Directory of Open Access Journals (Sweden)

    Minseok Seo

    Full Text Available BACKGROUND: The goal of feature selection is to select useful features and simultaneously exclude garbage features from a given dataset for classification purposes. This is expected to bring reduction of processing time and improvement of classification accuracy. METHODOLOGY: In this study, we devised a new feature selection algorithm (CBFS based on clearness of features. Feature clearness expresses separability among classes in a feature. Highly clear features contribute towards obtaining high classification accuracy. CScore is a measure to score clearness of each feature and is based on clustered samples to centroid of classes in a feature. We also suggest combining CBFS and other algorithms to improve classification accuracy. CONCLUSIONS/SIGNIFICANCE: From the experiment we confirm that CBFS is more excellent than up-to-date feature selection algorithms including FeaLect. CBFS can be applied to microarray gene selection, text categorization, and image classification.

  10. An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma

    National Research Council Canada - National Science Library

    Hakimi, A Ari; Reznik, Ed; Lee, Chung-Han; Creighton, Chad J; Brannon, A Rose; Luna, Augustin; Aksoy, B Arman; Liu, Eric Minwei; Shen, Ronglai; Lee, William; Chen, Yang; Stirdivant, Steve M; Russo, Paul; Chen, Ying-Bei; Tickoo, Satish K; Reuter, Victor E; Cheng, Emily H; Sander, Chris; Hsieh, James J

    2016-01-01

    .... We performed metabolomic profiling on 138 matched clear cell renal cell carcinoma (ccRCC)/normal tissue pairs and found that ccRCC is characterized by broad shifts in central carbon metabolism, one-carbon metabolism, and antioxidant response...

  11. Reconstruction of Clear-PEM data with STIR

    CERN Document Server

    Martins, M V; Rodrigues, P; Trindade, A; Oliveira, N; Correia, M; Cordeiro, H; Ferreira, N C; Varela, J; Almeida, P

    2006-01-01

    The Clear-PEM scanner is a device based on planar detectors that is currently under development within the Crystal Clear Collaboration, at CERN. The basis for 3D image reconstruction in Clear-PEM is the software for tomographic image reconstruction (STIR). STIR is an open source object-oriented library that efficiently deals with the 3D positron emission tomography data sets. This library was originally designed for the traditional cylindrical scanners. In order to make its use compatible with planar scanner data, new functionalities were introduced into the library's framework. In this work, Monte Carlo simulations of the Clear-PEM scanner acquisitions were used as input for image reconstruction with the 3D OSEM algorithm available in STIR. The results presented indicate that dual plate PEM data can be accurately reconstructed using the enhanced STIR framework.

  12. Molecular Air Data Clear Air Turbulence Sensor: MADCAT Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Clear air turbulence (CAT), often referred to as "air pockets," is attributed to Kelvin-Helmholtz instabilities at altitudes usually above 18,000ft, often without...

  13. Does clear cell carcinoma of stomach exist? Clinicopathological and prognostic significance of clear cell changes in gastric adenocarcinomas.

    Science.gov (United States)

    Kim, Joo-Yeon; Park, Do Youn; Kim, Gwang Ha; Jeon, Tae-Yong; Lauwers, Gregory Y

    2014-07-01

    In contrast to clear cell carcinomas developing in other organs (e.g. ovary and uterus), gastric adenocarcinomas with clear cell features are not well characterized. We evaluated a series of 762 gastric adenocarcinomas for the presence of clear cell changes; and investigated the nature of the changes using several histochemical and immunohistochemical markers, their association with various clinicopathological features, and their prognostic significance. Clear cell changes were observed in 8.5% (n = 65) of gastric cancers. Cases with clear cell changes (GCC) were associated significantly with older age, intestinal type histology, body/fundic location, greater depth of invasion, lymph node metastases and lymphovascular invasion. An increasing proportion of clear cell changes indicated a worsening prognosis, and was identified as an independent marker of poor prognosis using the Cox proportional hazard model (hazard ratio, 0.462; P = 0.003). Of 62 GCCs subjected to special staining, 35 cases (55.6%) displayed cytoplasmic accumulation of glycogen, while 21 (33.3%) contained mucin. GCCs showing glycogen accumulation expressed AFP, glypican-3 and CD10 more commonly than those with mucin, which commonly expressed Muc5AC and Muc6. Clear cell gastric adenocarcinoma is a unique subgroup of gastric cancer which, although heterogeneous, has a poor prognosis. © 2014 John Wiley & Sons Ltd.

  14. Coastal sediment elevation change following anthropogenic mangrove clearing

    Science.gov (United States)

    Hayden, Heather L.; Granek, Elise F.

    2015-11-01

    Coastal mangrove forests along tropical shorelines serve as an important interface between land and sea. They provide a physical buffer protecting the coastline from erosion and act as sediment "traps" catching terrestrial sediment, thus preventing smothering of subtidal coral reefs. Coastal development that removes mangrove habitat may impact adjacent nearshore coral reefs through sedimentation and nutrient loading. We examined differences in sediment elevation change between patches of open-coast intact and anthropogenically cleared red mangroves (Rhizophora mangle) on the east side of Turneffe Atoll, Belize, to quantify changes following mangrove clearing. Samples were collected over a 24 month period at five study sites, each containing paired intact (+mangrove) and cleared (-mangrove) plots. Five sediment elevation pins were deployed in each plot: behind areas cleared of mangroves (-mangrove) and behind adjacent intact mangroves (+mangrove). Sediment elevation increased at intact mangrove sites (M = +3.83 mm, SE = 0.95) whereas cleared mangrove areas suffered elevation loss (M = -7.30 mm, SE = 3.38). Mangroves inshore of partial or continuous gaps in the adjacent fringing reefs had higher rates of elevation loss (M = -15.05 mm) than mangroves inshore of continuous fringing reefs (M = -1.90 mm). Our findings provide information on potential effects of mangrove clearing and the role of offshore habitat characteristics on coastal sediment trapping and maintenance of sediment elevation by mangroves. With implications for coastline capacity to adjust to sea level rise, these findings are relevant to management of coastal fringing mangrove forests across the Caribbean.

  15. 78 FR 62719 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Advance...

    Science.gov (United States)

    2013-10-22

    ... as a systemically important financial market utility by the Financial Stability Oversight Council on July 18, 2012. See Financial Stability Oversight Council 2012 Annual Report, Appendix A, http://www...(n)(1)(i). I. Clearing Agency's Statement of the Terms of Substance of the Advance Notice...

  16. Levels of Evidence in Cosmetic Surgery: Analysis and Recommendations Using a New CLEAR Classification

    Directory of Open Access Journals (Sweden)

    Eric Swanson, MD

    2013-11-01

    Conclusions: The CLEAR classification considers methodological factors in evaluating study reliability. A prospective study among consecutive patients meeting eligibility criteria, with a reported inclusion rate, the use of contemporaneous controls when indicated, and consideration of confounders is a realistic goal. Such measures are likely to improve study quality.

  17. Charles Dickens' A Tale of Two Cities: a case report of posttraumatic stress disorder.

    Science.gov (United States)

    Huber, Thomas J; te Wildt, Bert T

    2005-01-01

    In posttraumatic stress disorder, a traumatic event is persistently re-experienced in the form of intrusive recollections, dreams or dissociative flashback episodes; cues to the event lead to distress and are avoided, and there are persistent symptoms of increased arousal. While this diagnostic concept has been widely discussed and its existence questioned, a novel written by Charles Dickens long before it was included in any diagnostic system can be viewed as an early case report of posttraumatic stress disorder.

  18. Establishment of a clean chemistry laboratory at JAERI. Clean laboratory for environmental analysis and research (CLEAR)

    Energy Technology Data Exchange (ETDEWEB)

    Hanzawa, Yukiko; Magara, Masaaki; Watanabe, Kazuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment] [and others

    2003-02-01

    The JAERI has established a facility with a cleanroom: the Clean Laboratory for Environmental Analysis and Research (CLEAR). This report is an overview of the design, construction and performance evaluation of the CLEAR in the initial stage of the laboratory operation in June 2001. The CLEAR is a facility to be used for analyses of ultra trace amounts of nuclear materials in environmental samples for the safeguards, for the CTBT verification and for researches on environmental sciences. One of the special features of the CLEAR is that it meets double requirements of a cleanroom and for handling of nuclear materials. As another feature of the CLEAR, much attention was paid to the construction materials of the cleanroom for trace analysis of metal elements using considerable amounts of corrosive acids. The air conditioning and purification system, specially designed experimental equipment to provide clean work surfaces, utilities and safety systems are also demonstrated. The potential contamination from the completed cleanroom atmosphere during the analytical procedure was evaluated. It can be concluded that the CLEAR has provided a suitable condition for reliable analysis of ultra trace amounts of nuclear materials and other heavy elements in environmental samples. (author)

  19. On the impact of self-clearing on electroactive polymer (EAP) actuators

    Science.gov (United States)

    Ahmed, Saad; Ounaies, Zoubeida; Lanagan, Michael T.

    2017-10-01

    Electroactive polymer (EAP)-based actuators have large potential for a wide array of applications; however, their practical implementation is still a challenge because of the requirement of high driving voltage, which most often leads to premature defect-driven electrical breakdown. Polymer-based capacitors have the ability to clear defects with partial electrical breakdown and subsequent removal of a localized electrode section near the defect. In this study, this process, which is known as self-clearing, is adopted for EAP technologies. We report a methodical approach to self-clear an EAP, more specifically P(VDF-TrFE-CTFE) terpolymer, to delay premature defect-driven electrical breakdown of the terpolymer actuators at high operating electric fields. Breakdown results show that electrical breakdown strength is improved up to 18% in comparison to a control sample after self-clearing. Furthermore, the electromechanical performance in terms of blocked force and free displacement of P(VDF-TrFE-CTFE) terpolymer-based bending actuators are examined after self-clearing and precleared samples show improved blocked force, free displacement and maximum sustainable electric field compared to control samples. The study demonstrates that controlled self-clearing of EAPs improves the breakdown limit and reliability of the EAP actuators for practical applications without impeding their electromechanical performance.

  20. Establishment of a clean chemistry laboratory at JAERI. Clean laboratory for environmental analysis and research (CLEAR)

    Energy Technology Data Exchange (ETDEWEB)

    Hanzawa, Yukiko; Magara, Masaaki; Watanabe, Kazuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment] [and others

    2003-02-01

    The JAERI has established a facility with a cleanroom: the Clean Laboratory for Environmental Analysis and Research (CLEAR). This report is an overview of the design, construction and performance evaluation of the CLEAR in the initial stage of the laboratory operation in June 2001. The CLEAR is a facility to be used for analyses of ultra trace amounts of nuclear materials in environmental samples for the safeguards, for the CTBT verification and for researches on environmental sciences. One of the special features of the CLEAR is that it meets double requirements of a cleanroom and for handling of nuclear materials. As another feature of the CLEAR, much attention was paid to the construction materials of the cleanroom for trace analysis of metal elements using considerable amounts of corrosive acids. The air conditioning and purification system, specially designed experimental equipment to provide clean work surfaces, utilities and safety systems are also demonstrated. The potential contamination from the completed cleanroom atmosphere during the analytical procedure was evaluated. It can be concluded that the CLEAR has provided a suitable condition for reliable analysis of ultra trace amounts of nuclear materials and other heavy elements in environmental samples. (author)

  1. Clearing the Cosmic Fog - The Most Distant Galaxy Ever Measured

    Science.gov (United States)

    2010-10-01

    A European team of astronomers using ESO's Very Large Telescope (VLT) has measured the distance to the most remote galaxy so far. By carefully analysing the very faint glow of the galaxy they have found that they are seeing it when the Universe was only about 600 million years old (a redshift of 8.6). These are the first confirmed observations of a galaxy whose light is clearing the opaque hydrogen fog that filled the cosmos at this early time. The results were presented at an online press conference with the scientists on 19 October 2010, and will appear in the 21 October issue of the journal Nature. "Using the ESO Very Large Telescope we have confirmed that a galaxy spotted earlier using Hubble is the most remote object identified so far in the Universe" [1], says Matt Lehnert (Observatoire de Paris) who is lead author of the paper reporting the results. "The power of the VLT and its SINFONI spectrograph allows us to actually measure the distance to this very faint galaxy and we find that we are seeing it when the Universe was less than 600 million years old." Studying these first galaxies is extremely difficult. By the time that their initially brilliant light gets to Earth they appear very faint and small. Furthermore, this dim light falls mostly in the infrared part of the spectrum because its wavelength has been stretched by the expansion of the Universe - an effect known as redshift. To make matters worse, at this early time, less than a billion years after the Big Bang, the Universe was not fully transparent and much of it was filled with a hydrogen fog that absorbed the fierce ultraviolet light from young galaxies. The period when the fog was still being cleared by this ultraviolet light is known as the era of reionisation [2]. Despite these challenges the new Wide Field Camera 3 on the NASA/ESA Hubble Space Telescope discovered several robust candidate objects in 2009 [3] that were thought to be galaxies shining in the era of reionisation. Confirming the

  2. Functional imaging in bulk tissue specimens using optical emission tomography: fluorescence preservation during optical clearing

    Science.gov (United States)

    Sakhalkar, H. S.; Dewhirst, M.; Oliver, T.; Cao, Y.; Oldham, M.

    2007-04-01

    Optical emission computed tomography (optical-ECT) is a technique for imaging the three-dimensional (3D) distribution of fluorescent probes in biological tissue specimens with high contrast and spatial resolution. In optical-ECT, functional information can be imaged by (i) systemic application of functional labels (e.g. fluorophore labelled proteins) and/or (ii) endogenous expression of fluorescent reporter proteins (e.g. red fluorescent protein (RFP), green fluorescent protein (GFP)) in vivo. An essential prerequisite for optical-ECT is optical clearing, a procedure where tissue specimens are made transparent to light by sequential perfusion with fixing, dehydrating and clearing agents. In this study, we investigate clearing protocols involving a selection of common fixing (4% buffered paraformaldehyde (PFA), methanol and ethanol), dehydrating (methanol and ethanol) and clearing agents (methyl salicylate and benzyl-alcohol-benzyl-benzoate (BABB)) in order to determine a 'fluorescence friendly' clearing procedure. Cell culture experiments were employed to optimize the sequence of chemical treatments that best preserve fluorescence. Texas red (TxRed), fluorescein isothiocyanate (FITC), RFP and GFP were tested as fluorophores and fluorescent reporter proteins of interest. Fluorescent and control cells were imaged on a microscope using a DSred2 and FITC filter set. The most promising clearing protocols of cell culture experiments were applied to whole xenograft tumour specimens, to test their effectiveness in large unsectioned samples. Fluorescence of TxRed/FITC fluorophores was not found to be significantly affected by any of the test clearing protocols. RFP and GFP fluorescence, however, was found to be significantly greater when cell fixation was in ethanol. Fixation in either PFA or methanol resulted in diminished fluorescence. After ethanol fixation, the RFP and GFP fluorescence proved remarkably robust to subsequent exposure to either methyl salicylate or BABB

  3. Diagnosis of clear sky ultraviolet radiation for Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Lemus Deschamps, L. [Bureau of Meteorology Research Centre (Australia); Galindo, I.; Solano, R.; Elizalde, A.T.; Fonseca, J. [Centro Universitario de Investigaciones en Ciencias del Ambiente, University of Colima (Mexico)

    2002-07-01

    A discrete-ordinate radiative transfer model is employed to develop a regional clear sky ultraviolet (UV) diagnosis system. The clear sky UV radiation, weighted by the spectral sensitivity of human skin is calculated using the Total Ozone Mapping Spectrometer (TOMS) data sets. Examples of the geographical clear sky UV Index distributions are presented and the model results are compared with surface UV measurements from University of Colima for 1999. [Spanish] Utilizando un modelo de transferencia de radiacion de ordenadas discretas se desarrolla un sistema para el diagnostico de la distribucion de radiacion ultravioleta para cielo despejado en la Republica Mexicana. La radiacion para cielo despejado se obtiene utilizando la respuesta espectral de la piel humana y los datos de satelite de ozono total registrados por el espectrometro TOMS. Se presentan ejemplos del Indice de radiacion ultravioleta (UV Index) calculados con el modelo y se comparan con las mediciones en superficie obtenidas en la Universidad de Colima durante 1999.

  4. Stiffness of RBC optical confinement affected by optical clearing

    Science.gov (United States)

    Grishin, Oleg V.; Fedosov, Ivan V.; Tuchin, Valery V.

    2017-03-01

    In vivo optical trapping is a novel applied direction of an optical manipulation, which enables one to noninvasive measurement of mechanical properties of cells and tissues in living animals directly. But an application area of this direction is limited because strong scattering of many biological tissues. An optical clearing enables one to decrease the scattering and therefore increase a depth of light penetration, decrease a distortion of light beam, improve a resolution in imaging applications. Now novel methods had appeared for a measurement an optical clearing degree at a cellular level. But these methods aren't applicable in vivo. In this paper we present novel measurement method of estimate of the optical clearing, which are based on a measurement of optical trap stiffness. Our method may be applicable in vivo.

  5. Mines and human casualties: a robotics approach toward mine clearing

    Science.gov (United States)

    Ghaffari, Masoud; Manthena, Dinesh; Ghaffari, Alireza; Hall, Ernest L.

    2004-10-01

    An estimated 100 million landmines which have been planted in more than 60 countries kill or maim thousands of civilians every year. Millions of people live in the vast dangerous areas and are not able to access to basic human services because of landmines" threats. This problem has affected many third world countries and poor nations which are not able to afford high cost solutions. This paper tries to present some experiences with the land mine victims and solutions for the mine clearing. It studies current situation of this crisis as well as state of the art robotics technology for the mine clearing. It also introduces a survey robot which is suitable for the mine clearing applications. The results show that in addition to technical aspects, this problem has many socio-economic issues. The significance of this study is to persuade robotics researchers toward this topic and to peruse the technical and humanitarian facets of this issue.

  6. Roadside and hydro line vegetation clearing: know your legal obligations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    This paper is intended to remind people of the negative impacts that vegetation-clearing activities have on nesting birds. Roadside and hydro line vegetation clearing affect the habitats and breeding grounds of migratory birds. It is urgent that responsibility be assumed for clearing activities and that greater care be taken protect these birds from negative consequences. Risk could be reduced by stopping vegetation clearance during nesting season. Moreover, project proponents have legal obligations under federal legislation that protects migratory birds. It is an offence to capture, injure, hurt or kill a migratory bird or remove, damage or destroy a migratory bird nest or eggs without a permit and for legitimate purposes. Offences against the Migratory Birds Convention Act, 1994, are punishable by fine.

  7. Study on application of optical clearing technique in skin diseases

    Science.gov (United States)

    Shan, Hao; Liang, Yanmei; Wang, Jingyi; Li, Yan

    2012-11-01

    So far, the study of the optical clearing is almost always about healthy tissue. However, the ultimate goal is to detect diseases for clinical application. Optical clearing on diseased skins is explored. The effect is evaluated by applying a combined liquid paraffin and glycerol mixed solution on several kinds of diseased skins in vitro. Scanning experiments from optical coherence tomography show that it has different effects among fibroma, pigmented nevus, and seborrheic keratosis. Based on the results, we conclude that different skin diseases have different compositions and structures, and their optical parameters and biological characteristics should be different, which implies that the optical clearing technique may have selectivity and may not be suitable for all kinds of skin diseases.

  8. Clear cell colitis: A form of microscopic colitis in children

    Institute of Scientific and Technical Information of China (English)

    Jan J(o)zefczuk; Bogdan Marian Wozniewicz

    2008-01-01

    AIM: To describe a new clinical and pathological subtype of microscopic colitis in children.METHODS: A selected group of children with abdominal pain, constipation and/or diarrhoea showing discrete or no macroscopic abnormalities on endoscopy was described.RESULTS: Multiple biopsies of colon showed large mononuclear clear cells in lamina propria of mucous membrane provided that good quality histological sections were performed and observed under a higher magnification. Otherwise, they could be misinterpreted as artefacts. Their presence in routine histology might suggest a systemic storage disease (Whipple's disease), and neuronal intestine dysplasia.Using immunohistochemical staining and electron microscopy we confirmed their origin from CD68 positive mononuclear macrophages.CONCLUSION: The presence of large clear cells is a constant microscopic feature. Failure of transient large bowel stationary macrophages plays a role in the pathogenesis of this benign microscopic clear cell colitis,sometimes coexisting with allergy.

  9. Tropospheric haze and colors of the clear daytime sky.

    Science.gov (United States)

    Lee, Raymond L

    2015-02-01

    To casual observers, haze's visible effects on clear daytime skies may seem mundane: significant scattering by tropospheric aerosols visibly (1) reduces the luminance contrast of distant objects and (2) desaturates sky blueness. However, few published measurements of hazy-sky spectra and chromaticities exist to compare with these naked-eye observations. Hyperspectral imaging along sky meridians of clear and hazy skies at one inland and two coastal sites shows that they have characteristic colorimetric signatures of scattering and absorption by haze aerosols. In addition, a simple spectral transfer function and a second-order scattering model of skylight reveal the net spectral and colorimetric effects of haze.

  10. Epidermization in the esophageal mucosa: unusual epithelial changes clearly detected by Lugol's staining.

    Science.gov (United States)

    Nakanishi, Y; Ochiai, A; Shimoda, T; Yamaguchi, H; Tachimori, Y; Kato, H; Watanabe, H; Hirohashi, S

    1997-05-01

    A 58-year-old Japanese man with superficial esophageal cancer accompanied by unusual epithelial changes, including esophageal mucosal epidermization, is reported. Staining with Lugol's iodine clearly showed irregular unstained lesions, which could not be seen clearly macroscopically, in the resected specimen. Histologic examination of the irregular unstained areas showed definite granular and horny layers regarded as epidermization, acanthosis with slight nuclear enlargement, and epithelial atrophy. The immunohistochemical staining patterns of keratins in the epidermized and atrophic lesions were similar to those in the epidermis, and the keratin staining patterns of the acanthotic lesion were similar to those of the oral epithelium.

  11. Quantitative assessment of hyaline cartilage elasticity during optical clearing using optical coherence elastography

    Science.gov (United States)

    Liu, Chih-Hao; Singh, Manmohan; Li, Jiasong; Han, Zhaolong; Wu, Chen; Wang, Shang; Idugboe, Rita; Raghunathan, Raksha; Zakharov, Valery P.; Sobol, Emil N.; Tuchin, Valery V.; Twa, Michael; Larin, Kirill V.

    2015-03-01

    We report the first study on using optical coherence elastography (OCE) to quantitatively monitor the elasticity change of the hyaline cartilage during the optical clearing administrated by glucose solution. The measurement of the elasticity is verified using uniaxial compression test, demonstrating the feasibility of using OCE to quantify the Young's modulus of the cartilage tissue. As the results, we found that the stiffness of the hyaline cartilage increases during the optical clearing of the tissue. This study might be potentially useful for the early detection of osteoarthritis disease.

  12. Notes on recollection and extended distribution of Rhynchotechum alternifolium C.B.Clarke (Gesneriaceae in Eastern Himalaya, Bhutan

    Directory of Open Access Journals (Sweden)

    Nripemo Odyuo

    2017-05-01

    Full Text Available Rhynchotechum alternifolium C.B.Clarke, a Gesneriaceae plant taxon earlier known from India and Myanmar, is reported here as an extended distribution to Bhutan. In India, earlier it was reported from Arunachal Pradesh, Assam, Manipur and Nagaland. The last observation of this taxon was in 1962 from Myanmar. During recent field exploration (2015, it is once again reported from Nagaland. Based on herbaria records, it is also recorded from Sikkim Himalaya. Brief taxonomic description along with photographic illustration and distribution map of the taxon is provided. Further investigation is required in the eastern Himalaya and North-eastern region of India to ascertain its present population status as well as IUCN status for conservation point of view.INTERNATIONAL JOURNAL OF ENVIRONMENTVolume-6, Issue-2, Mar-May 2017, Page: 1-8

  13. Marketing Strategies of United Kingdom Universities during Clearing and Adjustment

    Science.gov (United States)

    Mogaji, Emmanuel

    2016-01-01

    Purpose: The clearing system in the UK enables students without a university place after exam results have been announced to find suitable vacancies, as it is important for universities to fill their vacancies as any shortfall loses them a lot of money. The purpose of this paper is to examine marketing strategies adopted by UK universities on…

  14. Focus on Assignments: Keep Directions Clear and Simple.

    Science.gov (United States)

    Katz, Bruce; Klink, William

    1994-01-01

    At a Maryland middle school, teachers and students were asked how teachers routinely give medium-term and long-term assignments. Results showed that students, teachers, and parents would benefit from clearly written performance standards. The school's science fair assignment sheet specifies student and parent responsibilities, project completion…

  15. Clear Speech Variants: An Acoustic Study in Parkinson's Disease

    Science.gov (United States)

    Lam, Jennifer; Tjaden, Kris

    2016-01-01

    Purpose: The authors investigated how different variants of clear speech affect segmental and suprasegmental acoustic measures of speech in speakers with Parkinson's disease and a healthy control group. Method: A total of 14 participants with Parkinson's disease and 14 control participants served as speakers. Each speaker produced 18 different…

  16. Clearing the Fog from the Undergraduate Course in Linear Algebra

    Science.gov (United States)

    Scott, Damon

    2007-01-01

    For over a decade it has been a common observation that a "fog" passes over the course in linear algebra once abstract vector spaces are presented. See [2, 3]. We show how this fog may be cleared by having the students translate "abstract" vector-space problems to isomorphic "concrete" settings, solve the "concrete" problem either by hand or with…

  17. 31 CFR 50.12 - Clear and conspicuous disclosure.

    Science.gov (United States)

    2010-07-01

    ... INSURANCE PROGRAM Disclosures as Conditions for Federal Payment § 50.12 Clear and conspicuous disclosure. (a... circumstances of the disclosure. See § 50.17 for model forms. (b)(1) Description of premium. An insurer may..., consistent with the definition of an act of terrorism as amended by the Terrorism Risk Insurance...

  18. The Search for Durable Exterior Clear Coatings for Wood

    Directory of Open Access Journals (Sweden)

    Philip D. Evans

    2015-11-01

    Full Text Available The goal of a durable exterior clear coating has eluded generations of coatings technologists, despite long-standing desire amongst the public for such a coating. The journey towards this goal initially focused on modifications to coating formulation, but took a completely different direction when it was found that a UV-transparent silicone clear coating on wood modified with chromic acid met consumer expectations of coating durability. This finding sparked world-wide interest in wood pre-treatments as a way of enhancing the durability of clear coatings. This interest initially focused on transition metal compounds, but has now shifted in the direction of organic and inorganic photostabilizers or even more drastic pre-treatments. Pre-treatments that dimensionally stabilize wood, protect it from microbial degradation and photostabilize lignin, when combined with flexible, photostable, coatings provide the next way-stop on the journey towards achieving the goal of durable exterior clear coatings for wood. This paper reviews this journey, drawing upon our research and that of other groups who have focused on this elusive goal.

  19. Marketing Strategies of United Kingdom Universities during Clearing and Adjustment

    Science.gov (United States)

    Mogaji, Emmanuel

    2016-01-01

    Purpose: The clearing system in the UK enables students without a university place after exam results have been announced to find suitable vacancies, as it is important for universities to fill their vacancies as any shortfall loses them a lot of money. The purpose of this paper is to examine marketing strategies adopted by UK universities on…

  20. Does gently clearing the nasal passage affect odor identification?

    Directory of Open Access Journals (Sweden)

    Mitchell G. Spring

    2014-12-01

    Full Text Available Identifying scents in a wine’s bouquet is considered one of the most important steps in the process of wine tasting. An individual’s ability to successfully do this is dependent on the sense of smell; thus, altering the nasal microenvironment could have a powerful effect on the wine tasting experience. In the present study, we examined olfactory performance in healthy participants who cleared their nasal cavity before odorant presentations. Fifty undergraduate participants were assessed with a standardized test of olfaction requiring the recognition of a battery of odors. Half of these participants cleared mucus from their nasal cavities (by gently blowing their noses prior to the assessment. No difference was found in performance between those who cleared their nasal passages and those who did not. Further, data were not different than known population data from the test. These data suggest that gently clearing the nasal cavity before presentation of odorants bears no effect on the ability to perceive those odor qualities.

  1. Generalized clearness index frequency curves for the Russian Federation

    Science.gov (United States)

    Frid, S. E.; Popel, O. S.; Lisitskaya, N. V.; Kiseleva, S. V.

    2017-05-01

    Actinometric data of World Radiation Data Center and NASA POWER were used to get daily clearness index frequencies for Russia. The results obtained provide the opportunity to estimate more accurately the output of various types of solar power plants. Frequencies determined using the data sources indicated correlate well and differ from universal dependences that were recommended earlier for the entire globe.

  2. Seeing Clearly (A Cup of Health with CDC)

    Centers for Disease Control (CDC) Podcasts

    2014-05-08

    If you’re not seeing the world as clearly as you used to, you might be among the millions of people suffering from vision impairment. In this podcast, Dr. John Crews discusses ways to take care of your eyes.  Created: 5/8/2014 by MMWR.   Date Released: 5/8/2014.

  3. 19 CFR 4.60 - Vessels required to clear.

    Science.gov (United States)

    2010-04-01

    ... contiguous country otherwise than by sea. (c) Vessels which will merely transit the Panama Canal without transacting any business there shall not be required to be cleared because of such transit. (d) In the event... hours after clearance to the port director who shall note the fact of detention on the certificate...

  4. Skin optical clearing for improvement of laser tattoo removal

    Science.gov (United States)

    Genina, Elina A.; Bashkatov, Alexey N.; Gavrilova, Anna A.; Pravdin, Alexander B.; Tuchin, Valery V.; Yaroslavsky, Ilya V.; Altshuler, Gregory B.

    2007-06-01

    The removal of tattoo pigments by laser energy is effected through a process of selective photothermolysis. Dehydration and optical immersion based on refractive index matching of scattering centers with that of surrounding matter through introduction of an exogenous index-matching agent can improve laser tattoo removal by providing increased efficiency of laser delivery to embedded ink particles and enabling the use of shorter wavelength visible lasers more effective on certain inks. Effectiveness of a method of accelerating penetration of the index-matching compounds by enhancing skin permeability through creating a lattice of micro-zones of limited thermal damage in the stratum corneum was studied. As optical clearing agents 100% and 88%-aqueous glycerol solutions were used. The effect of stratum corneum perforation on the rate of the immersion clearing of skin was studied. Dynamics of refractive index alteration of glycerol solution during its interaction with skin samples was monitored. Improvement of tattoo visualization was observed. The results of the experiments have shown that the lattice of island damage method the is effective for transepidermal delivery of optical clearing agents and could be used successfully in in vivo conditions for the enhancement of optical clearing of treated skin area and as enabling improvement of laser tattoo removal.

  5. Treatment results and prognostic factors of clear cell ovarian carcinomas and ovarian carcinomas with clear cell component

    Directory of Open Access Journals (Sweden)

    M. D. Ahmedova

    2012-01-01

    Full Text Available The most important prognostic factors for clear cell carcinoma (CCC are clinical and morphological signs and clinical stage of the disease. Analyses of 5-year survival in patients with I stage of CCC is 69 %, in II stage – 55 %, in III stage – 14 % and in IV stage – 4 % patients. We analyzed distant results of treatment of 71 patients with CCC and of 25 patients with mixed malignant ovaries neoplasm with obligatory clear cell component taking into consideration main clinical and morphological sings of disease. On the base of performed reseal we revealed that morphological structure of the tumors and stage of the disease exerted heist influence on the exponent of survival of the patients with clear CCC ovaries neoplasm. Besides, there is a correlation between exponent of patients’ survival and radicalized of surgery, character of tumor growth, differentiation degree, cell anaplasia and mitotic activity of tumor cells.

  6. The potential of clear-sky carbon dioxide satellite retrievals

    Directory of Open Access Journals (Sweden)

    R. R. Nelson

    2015-12-01

    Full Text Available Since the launch of the Greenhouse Gases Observing Satellite (GOSAT in 2009, retrieval algorithms designed to infer the column-averaged dry-air mole fraction of carbon dioxide (XCO2 from hyperspectral near-infrared observations of reflected sunlight have been greatly improved. They now generally include the scattering effects of clouds and aerosols, as early work found that absorption-only retrievals, which neglected these effects, often incurred unacceptably large errors, even for scenes with optically thin cloud or aerosol layers. However, these "full-physics" retrievals tend to be computationally expensive and may incur biases from trying to deduce the properties of clouds and aerosols when there are none present. Additionally, algorithms are now available that can quickly and effectively identify and remove most scenes in which cloud or aerosol scattering plays a significant role. In this work, we test the hypothesis that non-scattering, or "clear-sky", retrievals may perform as well as full-physics retrievals for sufficiently clear scenes. Clear-sky retrievals could potentially avoid errors and biases brought about by trying to infer properties of clouds and aerosols when none are present. Clear-sky retrievals are also desirable because they are orders of magnitude faster than full-physics retrievals. Here we use a simplified version of the Atmospheric Carbon Observations from Space (ACOS XCO2 retrieval algorithm that does not include the scattering and absorption effects of clouds or aerosols. It was found that for simulated Orbiting Carbon Observatory-2 (OCO-2 measurements, the clear-sky retrieval had errors comparable to those of the full-physics retrieval. For real GOSAT data, the clear-sky retrieval had nearly indistinguishable error characteristics over land, but roughly 30–60 % larger errors over ocean, depending on filtration level, compared to the full-physics retrieval. In general, the clear-sky retrieval had XCO2 root

  7. Clear-air radar observations of the atmospheric boundary layer

    Science.gov (United States)

    Ince, Turker

    2001-10-01

    This dissertation presents the design and operation of a high-resolution frequency-modulated continuous-wave (FM- CW) radar system to study the structure and dynamics of clear-air turbulence in the atmospheric boundary layer (ABL). This sensitive radar can image the vertical structure of the ABL with both high spatial and temporal resolutions, and provide both qualitative information about the morphology of clear-air structures and quantitative information on the intensity of fluctuations in refractive-index of air. The principles of operation and the hardware and data acquisition characteristics of the radar are described in the dissertation. In October 1999, the radar participated in the Cooperative Atmosphere-Surface Exchange Study (CASES'99) Experiment to characterize the temporal structure and evolution of the boundary-layer features in both convective and stable conditions. The observed structures include clear-air convection, boundary layer evolution, gravity waves, Kelvin-Helmholtz instabilities, stably stratified layers, and clear-air turbulence. Many of the S-band radar images also show high- reflectivity returns from Rayleigh scatterers such as insects. An adaptive median filtering technique based on local statistics has, therefore, been developed to discriminate between Bragg and Rayleigh scattering in clear-air radar observations. The filter is tested on radar observations of clear air convection with comparison to two commonly used image processing techniques. The dissertation also examines the statistical mean of the radar-measured C2n for clear-air convection, and compares it with the theoretical predictions. The study also shows that the inversion height, local thickness of the inversion layer, and the height of the elevated atmospheric layers can be estimated from the radar reflectivity measurements. In addition, comparisons to the radiosonde-based height estimates are made. To examine the temporal and spatial structure of C2n , the dissertation

  8. Clear cell ovarian cancer and endometriosis: is there a relationship?

    Directory of Open Access Journals (Sweden)

    Maria Szubert

    2016-07-01

    Full Text Available Introduction: Ovarian clear cell carcinoma is a rare type of ovarian cancer. In recent years, issues of the common genetic origin of endometriosis and ovarian clear cell carcinoma have been raised. Aim of this study was to evaluate the prevalence of this type of cancer, risk factors, prognosis and its potential aetiological association with endometriosis. Material and methods: In a retrospective study, we analysed histopathological data of patients operated in the First Department of Gynaecology and Obstetrics (MU, Lodz due to ovarian cancer in 2004-2014. Among the 394 patients operated on for ovarian cancer, clear cell carcinoma was found in 0.02% (9/394. Menstrual history, parity, comorbidities, data from physical examination, operational protocols and histopathological diagnoses were analysed. Follow-up was obtained from 77.8% of patients. Statistical analysis was performed using Microsoft Excel 2013. Results: The mean age of patients at diagnosis was 57.6 years; the BMI in the study group was 27.2; the majority of patients were multiparous (77.8%. Clear cell carcinoma was detected mostly at stage Ia (n = 4. The concentration of Ca125 in the study group had an average of 142.75 U/ml and a median of 69.3 U/ml. The coexistence of endometriosis could not be clinically or histologically confirmed amongst our patients. The most common comorbidity in the study group was hypertension. Conclusions : In our clinical material, ovarian clear cell carcinoma is a rare histopathological specimen with a prognostic value comparable to that of serous ovarian cancer. Due to the rarity of this histopathological subtype, proving a cause-and-effect relationship between it and endometriosis can only be elucidated through statistical studies of the entire population.

  9. 17 CFR 17.00 - Information to be furnished by futures commission merchants, clearing members and foreign brokers.

    Science.gov (United States)

    2010-04-01

    ... products, the full date must be reported. For other options and futures, this field is used to report the... merchants, clearing members and foreign brokers. (a) Special accounts—reportable futures and options... quantity of exchanges of futures for commodities or for derivatives positions and the number of...

  10. Recuerdo, evocación, promesa. Contextos sentimentales del ajuar de camino = Recollection, Evocation, Promise. Sentimental Contexts of Travel Objects in the Modern Age.

    Directory of Open Access Journals (Sweden)

    Carmen Abad-Zardoya

    2016-12-01

    Full Text Available ResumenEn la Edad Moderna el viaje se consideraba poco más que un cúmulo de males necesarios para la consecución de un fin. Los objetos de camino cumplían funciones que iban más allá de cubrir una necesidad básica o de proporcionar pequeños lujos. Estrechamente vinculados a la identidad individual, algunos objetos funcionaron como soportes emocionales, imprescindibles para sobrellevar la rutina o sobreponerse a los momentos difíciles. A través de una selección de artículos de camino del siglo XVIII, rastreados en inventarios, testamentos y colecciones, se propone  una reflexión acerca de las expectativas que se depositaron en ellos, condensadas en tres ideas conductoras: recuerdo, evocación y promesa. AbstractTravel was considered along the Modern Age not much more than a cumulation of necessary evils which served to the consecution of a purpose. Travel equipment fulfilled therefore functions which went well beyond the coverage of basic needs or little luxuries. Some of these objects, closely linked to individual identities, functioned  as emotional supports, indispensable to bear daily routine or to overcome difficult moments. Through a selection of 18th –century  travel objects located in various  inventories, testaments and museum collections, I propose here a  general reflection on the different expectations which were deposited  on these objects using the  three key-concepts  recollection, evocation and promise.

  11. Does an information leaflet about surgical site infection (SSI) improve recollection of information and satisfaction of patients? A randomized trial in patients scheduled for digestive surgery.

    Science.gov (United States)

    Merle, Véronique; Marini, Hélène; Rongère, Julie; Tavolacci, Marie-Pierre; Scotté, Michel; Czernichow, Pierre

    2011-06-01

    A previous study suggested that most surgical patients do not remember having received information about surgical site infection (SSI). In other fields, written information has been suggested to improve patient satisfaction and recollection of information. Our objective was to assess if providing patients with written information about SSI, in addition to oral information, could influence patient satisfaction, recall of information, and opinion regarding SSI. A total of 207 patients scheduled for digestive surgery at a university hospital were randomized between usual oral information about SSI, plus an information leaflet about SSI (group O/L), or usual oral information alone (group O). Patients were interviewed 5 weeks after surgery to assess their recall and satisfaction regarding information, opinion regarding SSI, and declared intention of seeking legal action in case of SSI. Surgeons and interviewer were blinded to patients' group allocation. Recruitment occurred between October 2005 and August 2006. Of the original 207 patients, 161 patients (O/L=87, O=74) underwent operation and were interviewed as scheduled. Satisfaction was higher in group O/L (67% vs. O: 43%; P=0.003). The recall of having received information (O/L: 39% vs. O: 31%; P=0.29), was similar between the two groups. Judging SSI as always preventable was more frequent in group O/L (28% vs. O: 9%; P=0.004) with a trend toward a more frequent intention of seeking legal action (O/L: 10% vs. O: 3%; P=0.055). The leaflet did not improve patient recall of information about SSI, but it was associated with an increased level of satisfaction. The association between the leaflet and judging SSI as always preventable was unexpected.

  12. Remembering the Sea: Personal and Communal Recollections of Maritime Life in Jizan and the Farasan Islands, Saudi Arabia

    Science.gov (United States)

    Agius, Dionisius A.; Cooper, John P.; Semaan, Lucy; Zazzaro, Chiara; Carter, Robert

    2016-08-01

    People create narratives of their maritime past through the remembering and forgetting of seafaring experiences, and through the retention and disposal of maritime artefacts that function mnemonically to evoke or suppress those experiences. The sustenance and reproduction of the resulting narratives depends further on effective media of intergenerational transmission; otherwise, they are lost. Rapid socio-economic transformation across Saudi Arabia in the age of oil has disrupted longstanding seafaring economies in the Red Sea archipelago of the Farasan Islands, and the nearby mainland port of Jizan. Vestiges of wooden boatbuilding activity are few; long-distance dhow trade with South Asia, the Arabian-Persian Gulf and East Africa has ceased; and a once substantial pearling and nacre (mother of pearl) collection industry has dwindled to a tiny group of hobbyists: no youth dive today. This widespread withdrawal from seafaring activity among many people in these formerly maritime-oriented communities has diminished the salience of such activity in cultural memory, and has set in motion narrative creation processes, through which memories are filtered and selected, and objects preserved, discarded, or lost. This paper is a product of the encounter of the authors with keepers of maritime memories and objects in the Farasan Islands and Jizan. An older generation of men recall memories of their experiences as boat builders, captains, seafarers, pearl divers and fishermen. Their recounted memories are inscribed, and Arabic seafaring terms recorded. The extent of the retention of maritime material cultural items as memorials is also assessed, and the rôle of individual, communal and state actors in that retention is considered. Through this reflection, it becomes clear that the extra-biological memory and archive of the region's maritime past is sparse; that intergenerational transmission is failing; that the participation of state agencies in maritime heritage creation

  13. Bathymetry of Clear Creek Reservoir, Chaffee County, Colorado, 2016

    Science.gov (United States)

    Kohn, Michael S.; Kinzel, Paul J.; Mohrmann, Jacob S.

    2017-03-06

    To better characterize the water supply capacity of Clear Creek Reservoir, Chaffee County, Colorado, the U.S. Geological Survey, in cooperation with the Pueblo Board of Water Works and Colorado Mountain College, carried out a bathymetry survey of Clear Creek Reservoir. A bathymetry map of the reservoir is presented here with the elevation-surface area and the elevation-volume relations. The bathymetry survey was carried out June 6–9, 2016, using a man-operated boat-mounted, multibeam echo sounder integrated with a Global Positioning System and a terrestrial survey using real-time kinematic Global Navigation Satellite Systems. The two collected datasets were merged and imported into geographic information system software. The equipment and methods used in this study allowed water-resource managers to maintain typical reservoir operations, eliminating the need to empty the reservoir to carry out the survey.

  14. Clear sky atmosphere at cm-wavelengths from climatology data

    CERN Document Server

    Lew, Bartosz

    2015-01-01

    We utilise ground-based, balloon-born and satellite climatology data to reconstruct site and season-dependent vertical profiles of precipitable water vapour (PWV). We use these profiles to numerically solve radiative transfer through the atmosphere, and derive atmospheric brightness temperature ($T_{\\rm atm}$) and optical depth ($\\tau$) at the centimetre wavelengths. We validate the reconstruction by comparing the model column PWV, with photometric measurements of PWV, performed in the clear sky conditions towards the Sun. Based on the measurements, we devise a selection criteria to filter the climatology data to match the PWV levels to the expectations of the clear sky conditions. We apply the reconstruction to the location of the Polish 32-metre radio telescope, and characterise $T_{\\rm atm}$ and $\\tau$ year-round, at selected frequencies. We also derive the zenith distance dependence for these parameters, and discuss shortcomings of using planar, single-layer, and optically thin atmospheric model approxima...

  15. Effects of Mixing on Hopper Sedimentation in Clearing Mixtures

    DEFF Research Database (Denmark)

    Hjelmager Jensen, Jacob; Saremi, Sina

    2015-01-01

    and settling in high-concentration mixtures were examined theoretically. Analytical solutions for clearance of excess concentrations were derived for the limiting cases of (1) still-water clearance and (2) clearance when the amount of turbulence is abundant. When examining these analytical solutions......Hopper sedimentation is the result of precipitation of typically fine sediment from a homogenous, high-concentration mixture, which is not completely deficient of turbulence. If hopper sedimentation or loading is accomplished through a single-inflow system, or if the irregularity of the inflow...... concentrations is pronounced or simply terminated, then the hopper mixture will clear. Whereas turbulent mixing is redundant, when the mixture is homogeneous, it may take an active role when the mixture is clearing. The role of turbulence on hopper sedimentation has been the focus of several studies...

  16. Experimental characterization of the Clear-PEM scanner spectrometric performance

    Science.gov (United States)

    Bugalho, R.; Carriço, B.; Ferreira, C. S.; Frade, M.; Ferreira, M.; Moura, R.; Ortigão, C.; Pinheiro, J. F.; Rodrigues, P.; Rolo, I.; Silva, J. C.; Trindade, A.; Varela, J.

    2009-10-01

    In the framework of the Clear-PEM project for the construction of a high-resolution and high-specificity scanner for breast cancer imaging, a Positron Emission Mammography tomograph has been developed and installed at the Instituto Português de Oncologia do Porto hospital. The Clear-PEM scanner is mainly composed by two planar detector heads attached to a robotic arm, trigger/data acquisition electronics system and computing servers. The detector heads hold crystal matrices built from 2 × 2 × 20 mm3 LYSO:Ce crystals readout by Hamamatsu S8550 APD arrays. The APDs are optically coupled to both ends of the 6144 crystals in order to extract the DOI information for each detected event. Each one of 12288 APD's pixels is read and controlled by Application Specific Integrated Circuits water-cooled by an external cooling unit. The Clear-PEM frontend boards innovative design results in a unprecedented integration of the crystal matrices, APDs and ASICs, making Clear-PEM the PET scanner with the highest number of APD pixels ever integrated so far. In this paper, the scanner's main technical characteristics, calibration strategies and the first spectrometric performance evaluation in a clinical environment are presented. The first commissioning results show 99.7% active channels, which, after calibration, have inter-pixel and absolute gain distributions with dispersions of, respectively, 12.2% and 15.3%, demonstrating that despite the large number of channels, the system is uniform. The mean energy resolution at 511 keV is of 15.9%, with a 8.8% dispersion, and the mean CDOI-1 is 5.9%/mm, with a 7.8% dispersion. The coincidence time resolution, at 511 keV, for a energy window between 400 and 600 keV, is 5.2 ns FWHM.

  17. Decomposition of Market Clearing Price in Electricity Markets

    Science.gov (United States)

    Wachi, Tsunehisa; Fukutome, Suguru; Chen, Luonan; Makino, Yoshinori

    This paper aims to develop a novel methodology to decompose MCP (market clearing price) in a single price auction market with AC transmission network. Specifically, we first formulate the auction market as a nonlinear optimization problem, and then propose an algorithm to decompose MCP into various factors, such as bidding curves, generations, transmission congestion, voltage limitations and other constraints. Several numerical simulations have been used to demonstrate the effectiveness of our approach.

  18. Experimental characterization of the Clear-PEM scanner spectrometric performance

    Energy Technology Data Exchange (ETDEWEB)

    Bugalho, R; Carrico, B; Ferreira, C S; Frade, M; Ferreira, M; Moura, R; Ortigao, C; Pinheiro, J F; Rodrigues, P; Rolo, I; Silva, J C; Trindade, A; Varela, J [Laboratorio de Instrumentacao e Fisica Experimental de Particulas (LIP), Av. Elias Garcia 14-1, 1000-149 Lisboa (Portugal)], E-mail: frade@lip.pt

    2009-10-15

    In the framework of the Clear-PEM project for the construction of a high-resolution and high-specificity scanner for breast cancer imaging, a Positron Emission Mammography tomograph has been developed and installed at the Instituto Portugues de Oncologia do Porto hospital. The Clear-PEM scanner is mainly composed by two planar detector heads attached to a robotic arm, trigger/data acquisition electronics system and computing servers. The detector heads hold crystal matrices built from 2 x 2 x 20 mm{sup 3} LYSO:Ce crystals readout by Hamamatsu S8550 APD arrays. The APDs are optically coupled to both ends of the 6144 crystals in order to extract the DOI information for each detected event. Each one of 12288 APD's pixels is read and controlled by Application Specific Integrated Circuits water-cooled by an external cooling unit. The Clear-PEM frontend boards innovative design results in a unprecedented integration of the crystal matrices, APDs and ASICs, making Clear-PEM the PET scanner with the highest number of APD pixels ever integrated so far. In this paper, the scanner's main technical characteristics, calibration strategies and the first spectrometric performance evaluation in a clinical environment are presented. The first commissioning results show 99.7% active channels, which, after calibration, have inter-pixel and absolute gain distributions with dispersions of, respectively, 12.2% and 15.3%, demonstrating that despite the large number of channels, the system is uniform. The mean energy resolution at 511 keV is of 15.9%, with a 8.8% dispersion, and the mean C{sub DOI}{sup -1} is 5.9%/mm, with a 7.8% dispersion. The coincidence time resolution, at 511 keV, for a energy window between 400 and 600 keV, is 5.2 ns FWHM.

  19. A Case of Hyalinizing Clear Cell Carcinoma, So-Called Clear Cell Carcinoma, Not Otherwise Specified, of the Minor Salivary Glands of the Buccal Mucosa

    Directory of Open Access Journals (Sweden)

    Takahiro Yamanishi

    2015-01-01

    Full Text Available Hyalinizing clear cell carcinoma (HCCC, so-called clear cell carcinoma, not otherwise specified (CCC (NOS, of the salivary glands is a rare and low-grade malignant tumor. We report a case of HCCC so-called CCC (NOS (referred to as HCCC of the minor salivary gland of the buccal mucosa. A 52-year-old woman had presented with a gradually growing and indolent mass in the right buccal mucosa for about two years. The first biopsy histopathologically suggested the possibility of malignancy derived from the minor salivary glands. A month later, she visited our hospital. The tumor measured approximately 1.5 cm in diameter and was elastic hard, smooth, and well movable. Image examinations demonstrated internal homogeneity of the lesion, which had a smooth margin, in the right buccal mucosa. Complete tumor resection followed by covering with a polyglycolic acid sheet and fibrin glue spray was performed without surgical flap reconstruction. Histopathological findings revealed proliferating tumor cells with clear cytoplasm surrounded by hyalinizing stroma in the submucosal minor salivary glands. Immunohistochemical stains revealed these tumor cells to be positive for epithelial cell markers but negative for myoepithelial ones. These findings confirmed the diagnosis of HCCC. Good wound healing and no evidence of local recurrence and metastasis have been shown since surgery.

  20. Type 2 diabetes and impaired glucose tolerance are associated with word memory source monitoring recollection deficits but not simple recognition familiarity deficits following water, low glycaemic load, and high glycaemic load breakfasts.

    Science.gov (United States)

    Lamport, Daniel J; Lawton, Clare L; Mansfield, Michael W; Moulin, Chris A J; Dye, Louise

    2014-01-30

    It has been established that type 2 diabetes, and to some extent, impaired glucose tolerance (IGT), are associated with general neuropsychological impairments in episodic memory. However, the effect of abnormalities in glucose metabolism on specific retrieval processes such as source monitoring has not been investigated. The primary aim was to investigate the impact of type 2 diabetes and IGT on simple word recognition (familiarity) and complex source monitoring (recollection). A secondary aim was to examine the effect of acute breakfast glycaemic load manipulations on episodic memory. Data are presented from two separate studies; (i) 24 adults with type 2 diabetes and 12 controls aged 45-75years, (ii) 18 females with IGT and 47 female controls aged 30-50years. Controls were matched for age, IQ, BMI, waist circumference, and depression. Recognition of previously learned words and memory for specifically which list a previously learned word had appeared in (source monitoring) was examined at two test sessions during the morning after consumption of low glycaemic load, high glycaemic load and water breakfasts according to a counterbalanced, crossover design. Type 2 diabetes (p<0.05) and IGT (p<0.01) were associated with significant source monitoring recollection deficits but not impairments in familiarity. Impairments were only observed in the late postprandial stage at the second test session. These impairments were not attenuated by the breakfast glycaemic load manipulations. Isolated source monitoring recollection deficits indicate that abnormalities in glucose metabolism are not detrimental for global episodic memory processes. This enhances our understanding of how metabolic disorders are associated with memory impairments. © 2013.

  1. Hand-Assisted Laparoscopic Hepatectomy for Primary Clear Cell Hepatocellular Carcinoma of the Liver

    Directory of Open Access Journals (Sweden)

    Kazutoshi Kida

    2012-05-01

    Full Text Available We report a case of primary clear cell hepatocellular carcinoma of the liver (PCCCL for which we performed hand-assisted laparoscopic hepatectomy. A 71-year-old female with hepatitis C infection and diabetes mellitus was admitted to our department for a hepatic tumor with gallstone. Abdominal computed tomography revealed a tumor 25 mm in diameter on the surface in segment 5 of the liver. The imaging results suggested small hepatocellular carcinoma located on the surface in segment 5 of the liver, and we performed laparoscopic surgery aiming at a minimally invasive procedure. We performed laparoscopic cholecystectomy and hand-assisted laparoscopic hepatectomy. Histopathological findings showed moderately differentiated hepatocellular carcinoma, and as the proportion of clear cells was 75%, the tumor was diagnosed as PCCCL. This is the first report of hand-assisted laparoscopic hepatectomy for PCCCL. Laparoscopic hepatectomy is a useful minimally invasive surgical procedure when the tumor is located on the surface of the liver.

  2. Using clear aligner therapy to correct malocclusion with crowding and an open bite.

    Science.gov (United States)

    Harnick, David J

    2012-01-01

    Clear aligner therapy (CAT) has been used successfully to correct minor spacing and crowding. It generally has not been indicated in more complicated malocclusions such as skeletal discrepancies and open bites; however, recent advances in technology and practitioner expertise now allow the use of CAT in these situations. This case report demonstrates the use of a CAT system (Invisalign) to correct a Class II malocclusion with crowding and an open bite tendency.

  3. Accuracy of the ABC/2 score for intracerebral hemorrhage: Systematic review and analysis of MISTIE, CLEAR-IVH, CLEAR III

    Science.gov (United States)

    Webb, Alastair JS; Ullman, Natalie L; Morgan, Tim C; Muschelli, John; Kornbluth, Joshua; Awad, Issam A; Mayo, Stephen; Rosenblum, Michael; Ziai, Wendy; Zuccarrello, Mario; Aldrich, Francois; John, Sayona; Harnof, Sagi; Lopez, George; Broaddus, William C; Wijman, Christine; Vespa, Paul; Bullock, Ross; Haines, Stephen J; Cruz-Flores, Salvador; Tuhrim, Stan; Hill, Michael D; Narayan, Raj; Hanley, Daniel F

    2015-01-01

    Background and Purpose The ABC/2 score estimates intracerebral hemorrhage (ICH) volume, yet validations have been limited by small samples and inappropriate outcome measures. We determined accuracy of the ABC/2 score calculated at a specialized Reading Center (RC-ABC) or local site (site-ABC) versus the reference-standard CT-based planimetry (CTP). Methods In MISTIE-II, CLEAR-IVH and CLEAR-III trials, ICH volume was prospectively calculated by CTP, RC-ABC and site-ABC. Agreement between CTP and ABC/2 was defined as an absolute difference up to 5ml and relative difference within 20%. Determinants of ABC/2 accuracy were assessed by logistic regression. Results In 4369 scans from 507 patients, CTP was more strongly correlated with RC-ABC (r2=0.93) than site-ABC (r2=0.87). Although RC-ABC overestimated CTP-based volume on average (RC-ABC=15.2cm3, CTP=12.7cm3), agreement was reasonable when categorised into mild, moderate and severe ICH (kappa 0.75, p<0.001). This was consistent with overestimation of ICH volume in 6/8 previous studies. Agreement with CTP was greater for RC-ABC (84% within 5ml; 48% of scans within 20%) than for site-ABC (81% within 5ml; 41% within 20%). RC-ABC had moderate accuracy for detecting ≥ 5ml change in CTP volume between consecutive scans (sensitivity 0.76, specificity 0.86) and was more accurate with smaller ICH, thalamic haemorrhage and homogeneous clots. Conclusions ABC/2 scores at local or central sites are sufficiently accurate to categorise ICH volume and assess eligibility for the CLEAR III and MISTIE III studies, and moderately accurate for change in ICH volume. However, accuracy decreases with large, irregular or lobar clots. Clinical Trial Registration MISTIE-II NCT00224770; CLEAR-III NCT00784134; www.clinicaltrials.gov PMID:26243227

  4. A pilot study comparing opaque, weighted bottles with conventional, clear bottles for infant feeding.

    Science.gov (United States)

    Ventura, Alison K; Pollack Golen, Rebecca

    2015-02-01

    It is hypothesized that the visual and weight cues afforded by bottle-feeding may lead mothers to overfeed in response to the amount of liquid in the bottle. The aim of the present pilot study was to test this hypothesis by comparing mothers' sensitivity and responsiveness to infant cues and infants' intakes when mothers use opaque, weighted bottles (that remove visual and weight cues) compared to conventional, clear bottles to feed their infants. We also tested the hypothesis that mothers' pressuring feeding style would moderate the effect of bottle type. Formula-feeding dyads (N = 25) visited our laboratory on two separate days. Mothers fed their infants from a clear bottle one day and an opaque, weighted bottle on the other; bottle-order was counterbalanced across the two days. Infant intake was assessed by weighing each bottle before and after the feeding. Maternal sensitivity and responsiveness to infant cues was objectively assessed using the Nursing Child Assessment Feeding Scale. Mothers were significantly more responsive to infant cues when they used opaque compared to clear bottles (p = .04). There was also a trend for infants to consume significantly less formula when fed from opaque compared to clear bottles (p = .08). Mothers' pressuring feeding style moderated the effect of bottle type on maternal responsiveness to infant cues (p = .02) and infant intake (p = .03). Specifically, mothers who reported higher levels of pressuring feeding were significantly more responsive to their infants' cues (p = .02) and fed their infants significantly less formula when using opaque versus clear bottles (p = .01); no differences were seen for mothers who reported lower levels of pressuring feeding. This study highlights a simple, yet effective intervention for improving the bottle-feeding practices of mothers who have pressuring feeding styles.

  5. Temporal co-registration for TROPOMI cloud clearing

    Directory of Open Access Journals (Sweden)

    I. Genkova

    2012-03-01

    Full Text Available The TROPOspheric Monitoring Instrument (TROPOMI is anticipated to provide high-quality and timely global atmospheric composition information through observations of atmospheric constituents such as ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide, methane, formaldehyde and aerosol properties. The methane and the aerosol retrievals require very precise cloud clearing, which is difficult to achieve at the TROPOMI spatial resolution (7 by 7 km and without thermal IR measurements. The TROPOMI carrier – the Sentinel 5 Precursor (S5P, does not include a cloud imager, thus it is planned to fly the S5P mission in a constellation with an instrument yielding an accurate cloud mask. The cloud imagery data will be provided by the US NPOESS Preparatory Project (NPP mission, which will have the Visible Infrared Imager Radiometer Suite (VIIRS on board (Scalione, 2004. This paper investigates the temporal co-registration requirements for suitable time differences between the VIIRS measurements of clouds and the TROPOMI methane and aerosol measurements, so that the former could be used for cloud clearing. The temporal co-registration is studied using Meteosat Second Generation (MSG Spinning Enhanced Visible and Infrared Imager (SEVIRI data with 15 min temporal resolution (Veefkind, 2008b, and with data from the Geostationary Operational Environmental Satellite – 10 (GOES-10 having 1 min temporal resolution. The aim is to understand and assess the relation between the amount of allowed cloud contamination and the required time difference between the two satellites' overflights. Quantitative analysis shows that a time difference of approximately 5 min is sufficient (in most conditions to use the cloud information from the first instrument for cloud clearing in the retrievals using data from the second instrument. In recent years the A-train constellation demonstrated the benefit of flying satellites in formation. Therefore this study's findings will be

  6. The definition of IVM is clear-variations need defining.

    Science.gov (United States)

    De Vos, Michel; Smitz, Johan; Thompson, Jeremy G; Gilchrist, Robert B

    2016-11-01

    Oocyte in vitro maturation (IVM) is currently defined as the maturation in vitro of immature cumulus-oocyte complexes collected from antral follicles. This is the original definition as first described by Pincus and Enzmann and then by Edwards many decades ago, and this clear and unambiguous definition has served us well ever since. In an attempt to clarify apparent differences among clinicians, the following revised definition of IVM was recently proposed: 'The retrieval of oocytes from small and intermediate sized follicles in an ovary before the largest follicle has surpassed 13 mm in mean diameter'. As such, this proposed definition should encompass the use of hCG triggering. To change the clear and long-serving definition of IVM to fit varying clinical practices requires a compelling justification based on solid scientific and clinical grounds. We are of the opinion that the proposed revised definition of IVM is counterintuitive as it includes protocols that are intended to mature oocytes in vivo The proposed definitions are cumbersome and indeed further complicate the situation. It is not scientifically rational to base the definition on follicular size, and the definition ignores the vast corporate knowledge acquired from the many decades and >6000 publications in animal research that universally practices IVM as per the existing definition. Furthermore, such a definition can lead to false results in interpreting the follow-up of children conceived using IVM. Hence, we see no rationale to change the existing definition of IVM. However, we agree that variations on IVM require alternative nomenclature-these definitions need to be intuitive and need to clearly distinguish themselves from the existing long-standing definition of IVM. This would help to clarify the recent confusion within the clinical ART community as to what is and what is not, IVM.

  7. Hot Dry Rock resources of the Clear Lake area, California

    Energy Technology Data Exchange (ETDEWEB)

    Burns, K.L.; Potter, R.M. [Los Alamos National Lab., NM (United States); Peake, R.A. [California Energy Commission, CA (United States)

    1995-01-01

    The Hot Dry Rock resources of the Clear Lake area of northern California are hot, large and areally uniform. The geological situation is special, probably overlying a slabless window caused by interaction between tectonic plates. Consequent magmatic processes have created a high-grade resource, in which the 300{degree}C isotherm is continuous, subhorizontal, and available at the shallow depth of 2.4 to 4.7 km over an area of 800 km{sup 2}. The region is very favorable for HDR development.

  8. A giant benign clear cell hidradenoma on the anterior trunk

    Directory of Open Access Journals (Sweden)

    Damlanur Sakiz

    2011-10-01

    Full Text Available Clear cell hidroadenoma (CCA is a uncommon variant of bening cutaneous adnexial tumors. These tumors are clinically asymptomatic, solitary dermal nodules. they occur most frequently on the scalp, face, abdomen and the extremities. Growth is slow and malignant change is rare. 45- year-old woman presented us with a nodule with a central ulceration and a minimal hemoragic discharge on her anterior abdomen wall which had begun 4 years ago as a small nodular asymptomatic lesion. On dermatological examination there was a 6.5x4x5 cm non-tender, soft reddish purple nodule with lobular appearence and ulceration. In the laboratory investigations, all the hematologic and biochemical tests were normal. A CT scan demonstrated a cyctic tumor with lobulated countour with contrast enhancement. The lesion excised totally. In histopathological examination the tumor was composed of biphasic  smaller dark polygonal cells and larger clera cells and coarse nuclear chromatine. There were duct like structures. Immunohistochemical investigation was done for the suspicion of malignancy. Cytoplasm of clear cells and duct like structures showed PAS positive and d-Pas resistant staining. There was a positive reactivity to epithelial membrane antigen and carcinoembrionic antigen. The mitotic index in Ki 67 examination was low. All these findings confirmed the diagnosis of bening CCA. 

  9. Environment of deposition of Clear Fork Formation: Yoakum County, Texas

    Energy Technology Data Exchange (ETDEWEB)

    Moore, B.K.

    1987-05-01

    The Clear Fork Formation is Permian (Leonardian) in age and constitutes a major oil-bearing unit in the Permian basin of west Texas. In Yoakum County, west Texas, the upper Clear Fork carbonates record a subtidal upward-shoaling sequence of deposition. A small bryozoan-algal patch reef is situated within these carbonates near the southern edge of the North Basin platform. The reef is completely dolomitized, but paramorphic replacement has facilitated a study of the paleoecology, lateral variations, and community succession within this buildup. Build-ups of this type are scarcely known in strata of Permian age. The reef was apparently founded on a coquina horizon at the base of the buildup. The reef apparently had a low-relief, dome-shaped morphology. The trapping and binding of sediment by bryozoa appear to have been the main constructional process. A significant role was also played by encrusting forams and the early precipitation of submarine cements, both of which added rigidity to the structure. The reef also contains a low-diversity community of other invertebrates. Algal constituents predominate at the basinward edge of the buildup. The reef was formed entirely subaqueously on a broad, relatively shallow tropical marine carbonate shelf environment. An understanding of the lithofacies distribution and paragenesis within this sequence will provide information on porosity variations and the nature and distribution of permeability barriers. Such information is useful in reservoir modeling studies and for secondary recovery techniques in shelf-edge carbonate reservoirs of this type.

  10. Code Generation for Embedded Software for Modeling Clear Box Structures

    Directory of Open Access Journals (Sweden)

    V. Chandra Prakash

    2011-09-01

    Full Text Available Cleanroom software Engineering (CRSE recommended that the code related to the Application systems be generated either manually or through code generation models or represents the same as a hierarchy of clear box structures. CRSE has even advocated that the code be developed using the State models that models the internal behavior of the systems. No framework has been recommended by any Author using which the Clear boxes are designed using the code generation methods. Code Generation is one of the important quality issues addressed in cleanroom software engineering. It has been investigated that CRSE can be used for life cycle management of the embedded systems when the hardware-software co-design is in-built as part and parcel of CRSE by way of adding suitable models to CRSE and redefining the same. The design of Embedded Systems involves code generation in respect of hardware and Embedded Software. In this paper, a framework is proposed using which the embedded software is generated. The method is unique that it considers various aspects of the code generation which includes Code Segments, Code Functions, Classes, Globalization, Variable propagation etc. The proposed Framework has been applied to a Pilot project and the experimental results are presented.

  11. Primary abdominal wall clear cell carcinoma arising from incisional endometriosis

    Institute of Scientific and Technical Information of China (English)

    Burcu Gundogdu; Isin Ureyen; Gunsu Kimyon; Hakan Turan; Nurettin Boran; Gokhan Tulunay; Dilek Bulbul; Taner Turan; M Faruk Kose

    2013-01-01

    A 49 year-old patient with the complaint of a mass located in the caesarean scar was admitted. There was a fixed mass 30í30 mm in diameter with regular contour located at the right corner of the pfannenstiel incision. Computed tomography revealed a (40í50í50) mm solid mass lesion with margins that cannot be distinguished from the uterus, bladder and small intestines and a heterogeneous mass lesion (50í45í55) mm in diameter, located in the right side of the anterior abdominal wall. Cytoreductive surgery including total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed. Final pathology was clear cell carcinoma. Clear cell carcinoma arising from an extraovarian endometriotic focus was diagnosed and the patient received 6 cycles paclitaxel-carboplatin chemotherapy as adjuvant treatment. The patient who was lost to follow-up applied to our clinic 2 years after surgery with a recurrent mass in the left inguinal region. After 3 cycles of chemotherapy, the patient's tumoral mass in the left inguinal region was excised. The result of the pathology was carcinoma metastasis. It is decided that the following treatment of the patient should be palliative radiation therapy. The patient who underwent palliative radiation therapy died of disease after 4 months of the second operation.

  12. MODIS Observations of Enhanced Clear Sky Reflectance Near Clouds

    Science.gov (United States)

    Varnai, Tamas; Marshak, Alexander

    2009-01-01

    Several recent studies have found that the brightness of clear sky systematically increases near clouds. Understanding this increase is important both for a correct interpretation of observations and for improving our knowledge of aerosol-cloud interactions. However, while the studies suggested several processes to explain the increase, the significance of each process is yet to be determined. This study examines one of the suggested processes three-dimensional (3-D) radiative interactions between clouds and their surroundings by analyzing a large dataset of MODIS (Moderate Resolution Imaging Spectroradiometer) observations over the Northeast Atlantic Ocean. The results indicate that 3-D effects are responsible for a large portion of the observed increase, which extends to about 15 km away from clouds and is stronger (i) at shorter wavelengths (ii) near optically thicker clouds and (iii) near illuminated cloud sides. This implies that it is important to account for 3-D radiative effects in the interpretation of solar reflectance measurements over clear regions in the vicinity of clouds.

  13. APLIKASI SIX SIGMA PADA PRODUK CLEAR FILE DI PERUSAHAAN STATIONARY

    Directory of Open Access Journals (Sweden)

    Desy Emilasari

    2007-01-01

    Full Text Available This paper describes the application of the Six Sigma methods is used in order to improve quality in manufacturing company that produce stationary product. DMAIC approach is utilized to analyze and improve 'Pocket Clear File' product since this product has more variability and defects. Quality improvement also monitor the process that influenced pocket defect in Bag Making, Kami-ire, Karidome, and Pocket after Karidome Inspections section. Determining of Six Sigma project is based in process and defect type in each section. FMEA also gave the recommendation for quality improvement we need to evaluate the final result of the improvement since some of them were not working properly. Abstract in Bahasa Indonesia : Paper ini menggambarkan bagaimana aplikasi metode Six Sigma digunakan untuk melakukan perbaikan kualitas pada perusahaan manufaktur yang memproduksi produk stationary. Pendekatan DMAIC dipakai untuk menganalisa dan melakukan perbaikan produk 'Pocket Clear File' karena tingginya variabilitas dan cacat dibanding produk lain. Perbaikan kualitas juga memperhatikan proses yang mempengaruhi terjadinya cacat pocket pada section Bag Making, Kami-ire, Karidome, dan Pocket after Karidome Inspection. Penentuan proyek Six Sigma didasarkan atas proses dan jenis cacat pada setiap section. Pendekatan FMEA mampu memberi rekomendasi perbaikan kualitas. Evaluasi dari hasil perbaikan penting untuk dilakukan karena beberapa implementasi perbaikan kualitas tidak berjalan sesuai dengan rencana. kata kunci: six sigma, DMAIC, perusahaan stationary.

  14. Statistical functions and relevant correlation coefficients of clearness index

    Science.gov (United States)

    Pavanello, Diego; Zaaiman, Willem; Colli, Alessandra; Heiser, John; Smith, Scott

    2015-08-01

    This article presents a statistical analysis of the sky conditions, during years from 2010 to 2012, for three different locations: the Joint Research Centre site in Ispra (Italy, European Solar Test Installation - ESTI laboratories), the site of National Renewable Energy Laboratory in Golden (Colorado, USA) and the site of Brookhaven National Laboratories in Upton (New York, USA). The key parameter is the clearness index kT, a dimensionless expression of the global irradiance impinging upon a horizontal surface at a given instant of time. In the first part, the sky conditions are characterized using daily averages, giving a general overview of the three sites. In the second part the analysis is performed using data sets with a short-term resolution of 1 sample per minute, demonstrating remarkable properties of the statistical distributions of the clearness index, reinforced by a proof using fuzzy logic methods. Successively some time-dependent correlations between different meteorological variables are presented in terms of Pearson and Spearman correlation coefficients, and introducing a new one.

  15. Genetic characteristics of the non-clear cell renal cancer

    Directory of Open Access Journals (Sweden)

    D. S. Mikhaylenko

    2016-01-01

    Full Text Available Renal cancer (RC is one of the most frequent diseases in oncological urology; the most common form of RC is the clear cell carcinoma. However, percentage of less-studied non-clear cell RC (nccRC reaches up to 25 % of cases suggesting further studying, improvement of diagnosis and treatment of these tumors. The key events of carcinogenesis are genetic alterations including chromosomal aberrations and point mutations in proto-oncogenes and tumor suppressor genes. This review describes cytogenetic aberrations in the context of nccRC diversity according to the current ISUP classification. Translocation variants of nccRC (MiT-RC were characterized separately as particular cases of the chromosome rearrangements involving MiT gene family (TFE3, TFEB, MITF. In addition, the main nccRC hereditary forms caused by germinal mutations in the genes FLCN, FH, and MET, as well as recent studies of sporadic tumors with using the next generation sequencing techniques were reviewed. These experiments were designed to search for somatic mutations throughout the tumor genome or exom and revealed the different mutational profiles of I/II papillary RC subtypes, chromophobe carcinoma versus oncocytoma. The review may be informative for oncologists, urologists, geneticists and specialists in related sciences. 

  16. Dishonest deed, clear conscience: when cheating leads to moral disengagement and motivated forgetting.

    Science.gov (United States)

    Shu, Lisa L; Gino, Francesca; Bazerman, Max H

    2011-03-01

    People routinely engage in dishonest acts without feeling guilty about their behavior. When and why does this occur? Across four studies, people justified their dishonest deeds through moral disengagement and exhibited motivated forgetting of information that might otherwise limit their dishonesty. Using hypothetical scenarios (Studies 1 and 2) and real tasks involving the opportunity to cheat (Studies 3 and 4), the authors find that one's own dishonest behavior increased moral disengagement and motivated forgetting of moral rules. Such changes did not occur in the case of honest behavior or consideration of the dishonest behavior of others. In addition, increasing moral saliency by having participants read or sign an honor code significantly reduced unethical behavior and prevented subsequent moral disengagement. Although dishonest behavior motivated moral leniency and led to forgetting of moral rules, honest behavior motivated moral stringency and diligent recollection of moral rules.

  17. Temporal co-registration for TROPOMI cloud clearing

    Directory of Open Access Journals (Sweden)

    I. Genkova

    2011-10-01

    Full Text Available The TROPOspheric Monitoring Instrument (TROPOMI is planed for launch in 2014 on board of the Sentinel 5 Precursor (S5P and is anticipated to provide high-quality and timely information on the global atmospheric composition for climate and air quality applications. TROPOMI will observe key atmospheric constituents such as ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide, methane, formaldehyde and aerosol properties. The retrieval algorithms for the anticipated products require cloud information on a pixel basis. Most of them will use the cloud properties derived from TROPOMI's own measurements, such as the O2 A-band measurements. However, the methane and the aerosol retrievals require very precise cloud clearing, which is difficult to achieve at the TROPOMI spatial resolution (7 × 7 km2 and without thermal IR measurements. The current payload of the Sentinel 5 Precursor (S-5P does not include a cloud imager, thus it is planned to fly the S5P mission in a constellation with another instrument yielding an accurate cloud mask. The cloud imagery data will be provided by the US NPOESS Preparatory Project (NPP mission which will have the Visible Infrared Imager Radiometer Suite (VIIRS on board (Scalione, 2004. VIIRS will have 22 bands in the VIS and IR spectral ranges, and will deliver data with two spatial resolutions: imagery resolution bands with a nominal pixel size of 370 m at nadir, and moderate resolution bands with nominal pixel size 740 m at nadir. The instrument is combining fine spatial resolution with high-accuracy calibration similar or superior to AVHRR.

    This paper presents results from investigating the temporal co-registration requirements for suitable time differences between the VIIRS measurements of clouds and the TROPOMI methane and aerosol measurements, so that the former could be used for cloud clearing. The temporal co-registration is studied using Meteosat Second Generation (MSG Spinning

  18. Use of Digital Image Technology to 'Clearly' Depict Global Change

    Science.gov (United States)

    Molnia, B. F.; Carbo, C. L.

    2014-12-01

    Earth is dynamic and beautiful. Understanding why, when, how, and how fast its surface changes yields information and serves as a source of inspiration. The artistic use of geoscience information can inform the public about what is happening to their planet in a non-confrontational and apolitical way. While individual images may clearly depict a landscape, photographic comparisons are necessary to clearly capture and display annual, decadal, or century-scale impacts of climate and environmental change on Earth's landscapes. After years of effort to artistically communicate geoscience concepts with unenhanced individual photographs or pairs of images, the authors have partnered to maximize this process by using digital image enhancement technology. This is done, not to manipulate the inherent artistic content or information content of the photographs, but to insure that the comparative photo pairs produced are geometrically correct and unambiguous. For comparative photography, information-rich historical photographs are selected from archives, websites, and other sources. After determining the geographic location from which the historical photograph was made, the original site is identified and eventually revisited. There, the historical photos field of view is again photographed, ideally from the original location. From nearly 250 locations revisited, about 175 pairs have been produced. Every effort is made to reoccupy the original historical site. However, vegetation growth, visibility reduction, and co-seismic level change may make this impossible. Also, inherent differences in lens optics, camera construction, and image format may result in differences in the geometry of the new photograph when compared to the old. Upon selection, historical photos are cleaned, contrast stretched, brightness adjusted, and sharpened to maximize site identification and information extraction. To facilitate matching historical and new images, digital files of each are overlain in

  19. Clear-cell meningioma; CT and MR imaging findings in two cases involving the spinal canal and cerebellopontine angle

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Ki Bong; Lim, Myung Kwan; Kim, Hyung Jin; Suh, Chang Hae; Park, Hyung Chun; Kim, Eun Young; Han, Hye Seung [Inha University Hospital College of Medicine, Incheon (Korea, Republic of)

    2002-06-01

    Clear-cell meningioma is a rare subtype of meningioma which occurs at a younger age and has a higher recurrence rate than other subtypes. We report two cases of clear-cell meningioma, one in the thoracolumbar spinal canal and the other in the cerebellopontine angle. Though the CT and MR imaging findings were not different from those of ordinary meningioma, after surgical removal the condition recurred repeatedly in the patient with spinal canal involvement.

  20. Clear-Cell Meningioma: CT and MR Imaging Findings in Two Cases Involving the Spinal Canal and Cerebellopontine Angle

    Science.gov (United States)

    Yu, Ki Bong; Kim, Hyung Jin; Suh, Chang Hae; Park, Hyung Chun; Kim, Eun Young; Han, Hye Seung

    2002-01-01

    Clear-cell meningioma is a rare subtype of meningioma which occurs at a younger age and has a higher recurrence rate than other subtypes. We report two cases of clear-cell meningioma, one in the thoracolumbar spinal canal and the other in the cerebellopontine angle. Though the CT and MR imaging findings were not different from those of ordinary meningioma, after surgical removal the condition recurred repeatedly in the patient with spinal canal involvement. PMID:12087202

  1. Old-new ERP effects and remote memories: the late parietal effect is absent as recollection fails whereas the early mid-frontal effect persists as familiarity is retained

    Science.gov (United States)

    Tsivilis, Dimitris; Allan, Kevin; Roberts, Jenna; Williams, Nicola; Downes, John Joseph; El-Deredy, Wael

    2015-01-01

    Understanding the electrophysiological correlates of recognition memory processes has been a focus of research in recent years. This study investigated the effects of retention interval on recognition memory by comparing memory for objects encoded four weeks (remote) or 5 min (recent) before testing. In Experiment 1, event related potentials (ERPs) were acquired while participants performed a yes-no recognition memory task involving remote, recent and novel objects. Relative to correctly rejected new items, remote and recent hits showed an attenuated frontal negativity from 300–500 ms post-stimulus. This effect, also known as the FN400, has been previously associated with familiarity memory. Recent and remote recognition ERPs did not differ from each other at this time-window. By contrast, recent but not remote recognition showed increased parietal positivity from around 500 ms post-stimulus. This late parietal effect (LPE), which is considered a correlate of recollection-related processes, also discriminated between recent and remote memories. A second, behavioral experiment confirmed that remote memories unlike recent memories were based almost exclusively on familiarity. These findings support the idea that the FN400 and LPE are indices of familiarity and recollection memory, respectively and show that remote and recent memories are functionally and anatomically distinct. PMID:26528163

  2. The palm oil supply chain, deforestation and peat clearing

    Science.gov (United States)

    Boucher, D. H.

    2013-12-01

    The palm oil industry has expanded rapidly in the last two decades, particularly in Indonesia. A considerable amount of this expansion has been at the expense of forests and peatlands, resulting in considerable greenhouse gas emissions. Now the industry is faced with two new challenges. There is a possible oversupply on the global market due to recent expansion and the time lag between clearing and new production coming on line, which may depress prices considerably. Furthermore, there is increasing pressure to reduce the industry's impact on climate and biodiversity, exemplified by the commitment by the businesses of the Consumer Goods Forum to eliminate deforestation from their supply chains by 2020. This presentation will examine the interaction between these two challenges and its implications for the industry, in both southeast Asia and new regions of expansion, and how this interaction could transform the industry's mode of expansion in the coming decade.

  3. Proposal for a project agreement with ISTC - Crystal Clear Collaboration

    CERN Document Server

    2001-01-01

    This document concerns a project agreement with the ISTC entitled "Development of the Detector Production Technology for a New Generation of Positron Emission Tomographs to be used in Medecine and Pharmacology" to be executed in co-operation with the Crystal Clear Collaboration. For the reasons set out in this document, the Finance Committee is invited to agree to the negotiation of a project agreement with ISTC for a total amount of 775 000 US dollars. The European Union party in ISTC will co-fund the project up to a total of 525 000 US dollars. CERN's contribution will not exceed 250 000 US dollars. At the present rate of exchange this is equivalent to approximately 430 000 Swiss francs

  4. Use of clear lake as standard reflectors for atmospheric measurement

    Science.gov (United States)

    Ahern, F. J.; Goodenough, D. G.; Jain, S. C.; Rao, V. R.; Rochon, G.

    1977-01-01

    A method is proposed for using clear lakes as dark backgrounds against which the atmospheric path radiance can be determined from satellite observations. If the path radiance can be determined to sufficient accuracy, the atmospheric extinction can be inferred with suitable radiative transfer models. An extensive program of observation was made to determine the magnitude and variability of the various contributors to the total radiance observed by a satellite. It is shown that the volume and surface reflectance contributions (in the absence of sunglint) are small, constant, and can be modeled accurately enough to make these an insignificant source of error. The sunglint radiance observed in this investigation may be a significant source of error. It is shown that atmospheric extinction can be inferred from the path radiance observation after systematic differences between the model and observations are removed.

  5. Estimation of clear sky hourly global solar radiation in Iraq

    Energy Technology Data Exchange (ETDEWEB)

    Al-Jumaily, Kais J.; Al-Zuhairi, Munya F.; Mahdi, Zahraa S. [Department of Atmospheric Sciences, College of Science, Al-Mustansiriyah University, Baghdad (Iraq)

    2012-07-01

    The availability of hourly solar radiation data is very important for applications utilizing solar energy and for climate and environmental aspects. The aim of this work is to use a simple model for estimating hourly global solar radiation under clear sky condition in Iraq. Calculations were compared with measurements obtained from local station in Baghdad city and from Meteosat satellite data for different locations in Iraq. The statistical test methods of the mean bias error (MBE), root mean square error (RMSE) and t-test were used to evaluate the performance of the model. Results indicated that a fairly good agreement exists between calculated and measured values for all locations in Iraq. Since the model is independent of any meteorological variable, it would be of a practical use for rural areas where no meteorological data are available.

  6. An Immune Atlas of Clear Cell Renal Cell Carcinoma.

    Science.gov (United States)

    Chevrier, Stéphane; Levine, Jacob Harrison; Zanotelli, Vito Riccardo Tomaso; Silina, Karina; Schulz, Daniel; Bacac, Marina; Ries, Carola Hermine; Ailles, Laurie; Jewett, Michael Alexander Spencer; Moch, Holger; van den Broek, Maries; Beisel, Christian; Stadler, Michael Beda; Gedye, Craig; Reis, Bernhard; Pe'er, Dana; Bodenmiller, Bernd

    2017-05-04

    Immune cells in the tumor microenvironment modulate cancer progression and are attractive therapeutic targets. Macrophages and T cells are key components of the microenvironment, yet their phenotypes and relationships in this ecosystem and to clinical outcomes are ill defined. We used mass cytometry with extensive antibody panels to perform in-depth immune profiling of samples from 73 clear cell renal cell carcinoma (ccRCC) patients and five healthy controls. In 3.5 million measured cells, we identified 17 tumor-associated macrophage phenotypes, 22 T cell phenotypes, and a distinct immune composition correlated with progression-free survival, thereby presenting an in-depth human atlas of the immune tumor microenvironment in this disease. This study revealed potential biomarkers and targets for immunotherapy development and validated tools that can be used for immune profiling of other tumor types. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  7. An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma.

    Science.gov (United States)

    Hakimi, A Ari; Reznik, Ed; Lee, Chung-Han; Creighton, Chad J; Brannon, A Rose; Luna, Augustin; Aksoy, B Arman; Liu, Eric Minwei; Shen, Ronglai; Lee, William; Chen, Yang; Stirdivant, Steve M; Russo, Paul; Chen, Ying Bei; Tickoo, Satish K; Reuter, Victor E; Cheng, Emily H; Sander, Chris; Hsieh, James J

    2016-01-11

    Dysregulated metabolism is a hallmark of cancer, manifested through alterations in metabolites. We performed metabolomic profiling on 138 matched clear cell renal cell carcinoma (ccRCC)/normal tissue pairs and found that ccRCC is characterized by broad shifts in central carbon metabolism, one-carbon metabolism, and antioxidant response. Tumor progression and metastasis were associated with metabolite increases in glutathione and cysteine/methionine metabolism pathways. We develop an analytic pipeline and visualization tool (metabolograms) to bridge the gap between TCGA transcriptomic profiling and our metabolomic data, which enables us to assemble an integrated pathway-level metabolic atlas and to demonstrate discordance between transcriptome and metabolome. Lastly, expression profiling was performed on a high-glutathione cluster, which corresponds to a poor-survival subgroup in the ccRCC TCGA cohort. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. A Qualitative and Quantitative Evaluation of 8 Clear Sky Models.

    Science.gov (United States)

    Bruneton, Eric

    2016-10-27

    We provide a qualitative and quantitative evaluation of 8 clear sky models used in Computer Graphics. We compare the models with each other as well as with measurements and with a reference model from the physics community. After a short summary of the physics of the problem, we present the measurements and the reference model, and how we "invert" it to get the model parameters. We then give an overview of each CG model, and detail its scope, its algorithmic complexity, and its results using the same parameters as in the reference model. We also compare the models with a perceptual study. Our quantitative results confirm that the less simplifications and approximations are used to solve the physical equations, the more accurate are the results. We conclude with a discussion of the advantages and drawbacks of each model, and how to further improve their accuracy.

  9. All-clear for gourmets: truffles not radioactive

    Science.gov (United States)

    Büntgen, U.; Jäggi, M.; Stobbe, U.; Tegel, W.; Sproll, L.; Eikenberg, J.; Egli, S.

    2016-02-01

    Although ranging among the most expensive gourmet foods, it remains unclear whether Burgundy truffles (Tuber aestivum) accumulate radioactivity at a harmful level comparable to other fungal species. Here, we measure the 137Cs in 82 T. aestivum fruit bodies from Switzerland, Germany, France, Italy, and Hungary. All tested specimens reveal insignificant radiocaesium concentrations, thus providing an all-clear for many truffle hunters and cultivators in large parts of Europe as well as the subsequent chain of dealers and customers from around the world. Our results are particularly relevant in the light of ongoing efforts to cultivate Burgundy truffles, as well as the fact that several forest ecosystems are still highly contaminated with 137Cs, for which mushrooms are one of the main pathways to human diets.

  10. Clear Cell Adenocarcinoma Arising from Abdominal Wall Endometriosis

    Directory of Open Access Journals (Sweden)

    Thouraya Achach

    2008-01-01

    Full Text Available Endometriosis is a frequent benign disorder. Malignancy arising in extraovarian endometriosis is a rare event. A 49-year-old woman is presented with a large painful abdominal wall mass. She underwent a myomectomy, 20 years before, for uterus leiomyoma. Computed tomography suggested that this was a desmoid tumor and she underwent surgery. Histological examination showed a clear cell adenocarcinoma associated with endometriosis foci. Pelvic ultrasound, computed tomography, and endometrial curettage did not show any malignancy or endometriosis in the uterus and ovaries. Adjuvant chemotherapy was recommended, but the patient was lost to follow up. Six months later, she returned with a recurrence of the abdominal wall mass. She was given chemotherapy and then she was reoperated.

  11. Impacts of roads and linear clearings on tropical forests.

    Science.gov (United States)

    Laurance, William F; Goosem, Miriam; Laurance, Susan G W

    2009-12-01

    Linear infrastructure such as roads, highways, power lines and gas lines are omnipresent features of human activity and are rapidly expanding in the tropics. Tropical species are especially vulnerable to such infrastructure because they include many ecological specialists that avoid even narrow (forest edges, as well as other species that are susceptible to road kill, predation or hunting by humans near roads. In addition, roads have a major role in opening up forested tropical regions to destructive colonization and exploitation. Here, we synthesize existing research on the impacts of roads and other linear clearings on tropical rainforests, and assert that such impacts are often qualitatively and quantitatively different in tropical forests than in other ecosystems. We also highlight practical measures to reduce the negative impacts of roads and other linear infrastructure on tropical species.

  12. Temporal variation of clear-water scour at compound Abutments

    Directory of Open Access Journals (Sweden)

    Aminuddin Ab. Ghani

    2016-12-01

    Full Text Available Most of actual abutments in rivers are built on foundation, while there is limited number of study available on the effects of the foundation on the local scour. In this study, temporal variation of local scour around compound abutment was investigated experimentally under clear-water conditions. The results showed that a suitable level of foundation is able to decrease the scour depth and increase scour time during the flood events. The trend of temporal scour depth at compound pier and abutment is similar. The scour depth develops to top of foundation quickly, and then the foundation postpones the scour development (lag–time. Duration of lag–time depends on the foundation level, velocity ratio (U/Uc and foundation dimension. This study highlights that proper design of foundation level increases duration of scouring and provides enough time to treat bridge foundation after the flood events.

  13. Short imidazolium chains effectively clear fungal biofilm in keratitis treatment.

    Science.gov (United States)

    Liu, Lihong; Wu, Hong; Riduan, Siti Nurhanna; Ying, Jackie Y; Zhang, Yugen

    2013-01-01

    Fungal keratitis is a leading cause of ocular morbidity throughout the world. However, current therapies against fungal keratitis are often ineffective. Herein, we have developed the amphiphilic main-chain imidazolium polymer (PIM-45) and oligomer (IBN-1) materials that can efficiently inhibit the growth of fungi with low minimal inhibition concentration (MIC) values and clear the fungal biofilm, while displaying minimal hemolysis. In vivo keratitis treatment indicates that topical solutions of these polyimidazolium salts (PIMSs) are safe and as effective as that of amphotericin B, the most commonly used agent for the treatment of Candida albicans (C. albicans) keratitis. Compared to the costly and unstable amphotericin B and fluconazole, PIM-45 and IBN-1 are easy to prepare, inexpensive and stable. They can be stored in phosphate-buffered saline (PBS) solutions with long shelf life for routine topical use.

  14. Electricity market clearing with improved dispatch of stochastic production

    DEFF Research Database (Denmark)

    Morales González, Juan Miguel; Zugno, Marco; Pineda, Salvador;

    2014-01-01

    In this paper, we consider an electricity market that consists of a day-ahead and a balancing settlement, and includes a number of stochastic producers. We first introduce two reference procedures for scheduling and pricing energy in the day-ahead market: on the one hand, a conventional network......-constrained auction purely based on the least-cost merit order, where stochastic generation enters with its expected production and a low marginal cost; on the other, a counterfactual auction that also accounts for the projected balancing costs using stochastic programming. Although the stochastic clearing procedure...... attains higher market efficiency in expectation than the conventional day-ahead auction, it suffers from fundamental drawbacks with a view to its practical implementation. In particular, it requires flexible producers (those that make up for the lack or surplus of stochastic generation) to accept losses...

  15. Temperature gradients and clear-air turbulence probabilities

    Science.gov (United States)

    Bender, M. A.; Panofsky, H. A.; Peslen, C. A.

    1976-01-01

    In order to forecast clear-air turbulence (CAT) in jet aircraft flights, a study was conducted in which the data from a special-purpose instrument aboard a Boeing 747 jet airliner were compared with satellite-derived radiance gradients, conventional temperature gradients from analyzed maps, and temperature gradients obtained from a total air temperature sensor on the plane. The advantage of making use of satellite-derived data is that they are available worldwide without the need for radiosonde observations, which are scarce in many parts of the world. Major conclusions are that CAT probabilities are significantly higher over mountains than flat terrain, and that satellite radiance gradients appear to discriminate between CAT and no CAT better than conventional temperature gradients over flat lands, whereas the reverse is true over mountains, the differences between the two techniques being not large over mountains.

  16. Estrategia de redes sociales para la marca Clean&Clear

    OpenAIRE

    González Alzáibar, Gabriela

    2014-01-01

    Aquest treball és una proposta d'estratègia de xarxes socials per la marca Clean&Clear, que pertany al grup Johnson&Johnson. El treball constitueix una estratègia que té en compte tots els aspectes rellevants, per tant, es podria aplicar de forma immediata. Amb la intenció de dissenyar aquesta estratègia, s'analitza la situació actual de la marca a l'entorn social, així com la situació de la seva competència. Posteriorment, s’estudia el target i la penetració de les xarxes socials a Espanya p...

  17. Clear cell sarcoma (malignant melanoma of soft parts) and sentinel lymph node biopsy.

    Science.gov (United States)

    Picciotto, Franco; Zaccagna, Alessandro; Derosa, Giovanni; Pisacane, Alberto; Puiatti, Paolo; Colombo, Enrico; Dardano, Fabrizio; Ottinetti, Antonio

    2005-01-01

    Clear cell sarcoma of the tendons and aponeuroses is an aggressive, rare soft tissue tumour that occurs predominantly in the extremities of young adults. Although it appears to be histogenetically related to melanoma, its clinical behaviour resembles soft tissue sarcoma. Prognosis is reported to be poor due to the great propensity of regional and distant metastases. The risk of metastases to regional lymph nodes is very high. We describe a case of clear cell sarcoma of the hand and evaluate the feasibility of the sentinel lymph node biopsy (SLNB) technique in this kind of tumour. Up to now, there are no reports that describe the use of SLNB in clear cell sarcoma. The SLNB technique was carried out with success and the sentinel lymphnode was easily identified. Histological examination of the lymphnode allowed identification of metastatic cells and thus provide for radical lymphadenectomy. We maintain that SLNB can be successfully used for this type of tumour although this result should be evaluated and confirmed by larger case studies.

  18. The utility of using immunohistochemistry in the differentiation of metastatic, cutaneous clear cell renal cell carcinoma and clear cell hidradenoma.

    Science.gov (United States)

    Velez, Moises J; Thomas, Courtney L; Stratton, Jason; Bergfeld, Wilma; Weaver, Joshua

    2017-04-04

    Clear cell hidradenoma and cutaneous clear cell renal cell carcinoma (CCRCC) overlap morphologically. The distinction may be difficult in a patient with a history of CCRCC, presenting with a cutaneous nodule, potentially leading to an erroneous diagnosis. We investigated the usefulness of napsin A and paired box gene 8 (PAX-8) with previously studied markers epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), vimentin and cluster of differentiation marker 10 (CD10) in differentiating CCRCC from hidradenoma. We evaluated hidradenomas and cutaneous CCRCCs for immunohistochemical expression of napsin A, PAX-8, EMA, CEA, vimentin and CD10. PAX-8 was expressed in all CCRCCs (8/8) while negative in hidradenomas. Napsin A was negative in both hidradenomas (0/12) and CCRCCs (0/10). EMA showed membranous reactivity in 11 of 12 hidradenomas and 8 of 10 CCRCCs; and highlighted ductal epithelium in 1 of 12 hidradenomas and cystic areas in 4 of 10 CCRCCs. CD10 showed ductal expression in 3 of 12 hidradenomas and membranous staining in 8 of 9 CCRCCs. CEA highlighted ductal epithelium in 11 of 12 hidradenomas while absent in CCRCCs (0/10). Vimentin highlighted neoplastic cells in 8 of 8 CCRCCs and failed to stain the hidradenomas (0/12). A conservative immunohistochemical panel including PAX-8, vimentin and CEA allow for easy distinction of CCRCC from hidradenoma, whereas napsin A added no additional value. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  19. Vegetation change in large clearings: Patterns in the Chilean matorral.

    Science.gov (United States)

    Fuentes, Eduardo R; Hoffmann, Alicia J; Poiani, Aldo; Alliende, María C

    1986-09-01

    Previous studies have shown that in Chile the so called mature matorral can have the form of either a continuous matrix of shrubs (wet sites) or of multispecific clumps of shrubs (dry sites). After clearing, sites are known to be initially covered by annuals and then byBaccharis spp. orAcacia caven shrubs. Further vegetation changes are still not documented. In the first part of this contribution we show evidence indicating that the "seed rain" of plants dispersed by birds is important only around bird perches and that in general "seed shadows" of mature matorral shrubs are small. These results suggest that late recolonization of cleared areas occurs by a slow diffusion process in which the presence of perching sites for birds plays a significant role. Then we exhibit results regarding the importance of seasonal droughts and European rabbits in explaining transitions between the various types of plant cover. Here we conclude that nursing by older shrubs and not by rocks or fallen branches, is a requirement to insure the survival of seedlings belonging to mature matorral shrubs. Nurses are important regarding both summer desiccation and herbivory. These nurse effects seem to be more important at dry sites where rabbits are also more numerous, than at wet sites where conditions seem somewhat milder and vegetation change could be faster. In the last part we discuss a scheme of vegetation change that incorporates these processes and explains the relation between them, the vegetation types and the recolonization of wet and dry areas. Finally, a brief mention is made to the difference between these processes and the comparable ones in the California chaparral.

  20. Endogenous Market-Clearing Prices and Reference Point Adaptation

    Science.gov (United States)

    Dragicevic, Arnaud Z.

    When prices depend on the submitted bids, i.e. with endogenous market-clearing prices in repeated-round auction mechanisms, the assumption of independent private values that underlines the property of incentive-compatibility is to be brought into question; even if these mechanisms provide active involvement and market learning. In its orthodox view, adaptive bidding behavior imperils incentive-compatibility. We relax the assumption of private values' independence in the repeated-round auctions, when the market-clearing prices are made public at the end of each round. Instead of using game-theory learning models, we introduce a behavioral model that shows that bidders bid according to the anchoring-and-adjustment heuristic, which neither ignores the rationality and incentive-compatibility constraints, nor rejects the posted prices issued from others' bids. Bidders simply weight information at their disposal and adjust their discovered value using reference points encoded in the sequential price weighting function. Our model says that bidders and offerers are sincere boundedly rational utility maximizers. It lies between evolutionary dynamics and adaptive heuristics and we model the concept of inertia as high weighting of the anchor, which stands for truthful bidding and high regard to freshly discovered preferences. Adjustment means adaptive rule based on adaptation of the reference point in the direction of the posted price. It helps a bidder to maximize her expected payoff, which is after all the only purpose that matters to rationality. The two components simply suggest that sincere bidders are boundedly rational. Furthermore, by deviating from their anchor in the direction of the public signal, bidders operate in a correlated equilibrium. The correlation between bids comes from the commonly observed history of play and each bidder's actions are determined by the history. Bidders are sincere if they have limited memory and confine their reference point adaptation

  1. Sediment properties and CO2 efflux from intact and cleared temperate mangrove forests

    Science.gov (United States)

    Bulmer, R. H.; Lundquist, C. J.; Schwendenmann, L.

    2015-10-01

    Temperate mangrove forests in New Zealand have increased in area over recent decades. Expansion of temperate mangroves in New Zealand is associated with perceived loss of other estuarine habitats, and decreased recreational and amenity values, resulting in clearing of mangrove forests. In the tropics, changes in sediment characteristics and carbon efflux have been reported following mangrove clearance. This is the first study in temperate mangrove (Avicennia marina) forests investigating the impact of clearing on sediment CO2 efflux and associated biotic and abiotic factors. Sediment CO2 efflux rates from intact (168.5 ± 45.8 mmol m-2 d-1) and cleared (133.9 ± 37.2 mmol m-2 d-1) mangrove forests in New Zealand are comparable to rates measured in tropical mangrove forests. We did not find a significant difference in sediment CO2 efflux rates between intact and cleared temperate mangrove forests. Pre-shading the sediment for more than 30 min prior to dark chamber measurements was found to have no significant effect on sediment CO2 efflux. This suggests that the continuation of photosynthetic CO2 uptake by biofilm communities was not occurring after placement of dark chambers. Rather, above-ground mangrove biomass, sediment temperature and chlorophyll a concentration were the main factors explaining the variability in sediment CO2 efflux in intact mangrove forests. The main factors influencing sediment CO2 efflux in cleared mangrove forest sites were sediment organic carbon concentration, nitrogen concentration and sediment grain size. Our results show that greater consideration should be given regarding the rate of carbon released from mangrove forest following clearance and the relative contribution to global carbon emissions.

  2. Clear cell myoepithelioma of palate with emphasis on clinical and histological differential diagnosis.

    Science.gov (United States)

    Nair, Bindu J; Vivek, Velayudhannair; Sivakumar, Trivandrum T; Joseph, Anna P; Varun, Babyamma Raghavanpillai; Mony, Vinod

    2014-03-27

    Myoepitheliomas account for less than 1% of all salivary gland tumors and mostly occur in the parotid gland and palate. A 58-year old male patient reported to the Outpatient Department of PMS College of Dental Science and Research (Kerala, India) with a slow growing painless swelling on the palate for 4 years. Pleomorphic adenoma, basal cell adenoma, myoepithelioma, cyst adenoma, lipoma, neurofibroma, neurilemmoma and leiomyoma were considered. Histopathology revealed a thinly encapsulated tumor composed mainly of sheets of clear cells mixed with cells having eosinophilic cytoplasm. Histopathological differential diagnosis included pleomorphic adenoma, oncocytoma, oncocytic hyperplasia, sebaceous adenoma, malignant salivary gland neoplasms and metastatic lesions from kidney and thyroid. Myoepitheliomas mostly occur in the parotid gland and palatal region and various histological types of myoepithelioma are described. Myoepitheliomas of the palate are rare with clear cell variant even rarer.

  3. Contract Pricing: Threshold for Analysis of Subcontract Proposals Not Clear

    Science.gov (United States)

    1992-03-01

    packages, valued at $255 million. If the 3Contract Pricing: Inadequate Subcontract Evaluations Often Lead to Higher Government Costo (GAO/NSIAD-9l-16 1, Apr...report. Other major contributors to this report are listed in appendix III . Sincerely yours, Paul F. Math Director, Research, Development, Acquisition...subcontractor cost or See comment 2. pricing data. FAR 15.804-2(a)(1)( iii ) states that any subcontract expected to exceed $100,000 _l/ requires the submission

  4. Quantifying changes in the rates of forest clearing in Indonesia from 1990 to 2005 using remotely sensed data sets

    Science.gov (United States)

    Hansen, Matthew C.; Stehman, Stephen V.; Potapov, Peter V.; Arunarwati, Belinda; Stolle, Fred; Pittman, Kyle

    2009-07-01

    Timely and accurate data on forest change within Indonesia is required to provide government, private and civil society interests with the information needed to improve forest management. The forest clearing rate in Indonesia is among the highest reported by the United Nations Food and Agriculture Organization (FAO), behind only Brazil in terms of forest area lost. While the rate of forest loss reported by FAO was constant from 1990 through 2005 (1.87 Mha yr-1), the political, economic, social and environmental drivers of forest clearing changed at the close of the last century. We employed a consistent methodology and data source to quantify forest clearing from 1990 to 2000 and from 2000 to 2005. Results show a dramatic reduction in clearing from a 1990s average of 1.78 Mha yr-1 to an average of 0.71 Mha yr-1 from 2000 to 2005. However, annual forest cover loss indicator maps reveal a near-monotonic increase in clearing from a low in 2000 to a high in 2005. Results illustrate a dramatic downturn in forest clearing at the turn of the century followed by a steady resurgence thereafter to levels estimated to exceed 1 Mha yr-1 by 2005. The lowlands of Sumatra and Kalimantan were the site of more than 70% of total forest clearing within Indonesia for both epochs; over 40% of the lowland forests of these island groups were cleared from 1990 to 2005. The method employed enables the derivation of internally consistent, national-scale changes in the rates of forest clearing, results that can inform carbon accounting programs such as the Reducing Emissions from Deforestation and Forest Degradation in Developing Countries (REDD) initiative.

  5. Childhood to adolescence: dust and gas clearing in protoplanetary disks

    Science.gov (United States)

    Brown, Joanna Margaret

    Disks are ubiquitous around young stars. Over time, disks dissipate, revealing planets that formed hidden by their natal dust. Since direct detection of young planets at small orbital radii is currently impossible, other tracers of planet formation must be found. One sign of disk evolution, potentially linked to planet formation, is the opening of a gap or inner hole in the disk. In this thesis, I have identified and characterized several cold disks with large inner gaps but retaining massive primordial outer disks. While cold disks are not common, with ~5% of disks showing signs of inner gaps, they provide proof that at least some disks evolve from the inside-out. These large gaps are equivalent to dust clearing from inside the Earth's orbit to Neptune's orbit or even the inner Kuiper belt. Unlike more evolved systems like our own, the central star is often still accreting and a large outer disk remains. I identified four cold disks in Spitzer 5-40 μm spectra and modeled these disks using a 2-D radiative transfer code to determine the gap properties. Outer gap radii of 20-45 AU were derived. However, spectrophotometric identification is indirect and model-dependent. To validate this interpretation, I observed three disks with a submillimeter interferometer and obtained the first direct images of the central holes. The images agree well with the gap sizes derived from the spectrophotometry. One system, LkH&alpha 330, has a very steep outer gap edge which seems more consistent with gravitational perturbation rather than gradual processes, such as grain growth and settling. Roughly 70% of cold disks show CO v=1&rarr 0 gas emission from the inner 1 AU and therefore are unlikely to have evolved due to photoevaporation. The derived rotation temperatures are significantly lower for the cold disks than disks without gaps. Unresolved (sub)millimeter photometry shows that cold disks have steeper colors, indicating that they are optically thin at these wavelengths, unlike

  6. Prisoner's Dilemma: Reflections and Recollections.

    Science.gov (United States)

    Rapoport, Anatol

    1995-01-01

    Traces the roots of social trap situations and describes a parasitism-symbiosis model, showing that when each organism attempts to maximize its survival potential without regard for the other's, neither does as well as when they behave collectively. Discusses a model social trap situation, "Prisoner's Dilemma" ("PD") and a…

  7. Andrew A. Benson: personal recollections.

    Science.gov (United States)

    Nonomura, Arthur; Lorimer, George; Holtz, Barry; Vacquier, Victor; Biel, Karl Y; Govindjee

    2016-03-01

    Andrew A. Benson, one of the greatest and much loved scientists of our century, passed away on January 16, 2015; he was born on September 24, 1917. A grand celebration of his life was held on February 6, 2015, in California. Here, we present one of his photographs and key excerpts from what was said then, and soon thereafter.

  8. Eye movements predict recollective experience.

    Directory of Open Access Journals (Sweden)

    Tali Sharot

    Full Text Available Previously encountered stimuli can bring to mind a vivid memory of the episodic context in which the stimulus was first experienced ("remembered" stimuli, or can simply seem familiar ("known" stimuli. Past studies suggest that more attentional resources are required to encode stimuli that are subsequently remembered than known. However, it is unclear if the attentional resources are distributed differently during encoding and recognition of remembered and known stimuli. Here, we record eye movements while participants encode photos, and later while indicating whether the photos are remembered, known or new. Eye fixations were more clustered during both encoding and recognition of remembered photos relative to known photos. Thus, recognition of photos that bring to mind a vivid memory for the episodic context in which they were experienced is associated with less distributed overt attention during encoding and recognition. The results suggest that remembering is related to encoding of a few distinct details of a photo rather than the photo as a whole. In turn, during recognition remembering may be trigged by enhanced memory for the salient details of the photos.

  9. My recollections as a physicist

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, Yung-su

    1997-03-01

    This presentation is a talk presented by the author at a Physics Symposium of the 50th anniversary of the Taiwan University, in December 1996. The author describes how he became a physicist, and then presents a brief outline of his professional career, most of which has centered at Stanford Linear Accelerator Center. He was involved in the discovery of the {tau} lepton, and in studies of CP violation through decay of the {tau}, in addition to studies of semileptonic decay of t, B, D, K, and {pi}.

  10. Flavio Baroncelli: A Personal Recollection

    Directory of Open Access Journals (Sweden)

    Mikael M. Karlsson

    2008-03-01

    Full Text Available Flavio Baroncelli was a formidable philosopher, albeit an unusual—and even "disquieting"—one. His work is well known in Italy, but little known in other countries. The obvious explanation for this is that Flavio wrote and published almost exclusively in Italian. And that was no accident, for he knew English well and could easily have written much more in English in order to raise his international profile. But for Flavio, the Italian language was a basic philosophical instrument. He employed a great deal of straightforward (and clever analytical argument. But he also argued (like Nietzsche by means of humor, irony, story-telling and various forms of linguistic artistry. For this, he needed Italian, in which language he was a master craftsman.

  11. Julian Schwinger — Personal Recollections

    Science.gov (United States)

    Martin, Paul C.

    We're gathered here today to salute Julian Schwinger, a towering figure of the golden age of physics — and a kind and gentle human being. Even at our best universities, people with Julian's talent and his passion for discovery and perfection are rare — so rare that neither they nor the rest of us know how to take best advantage of their genius. The failure to find a happier solution to this dilemma in recent years has concerned many of us. It should not becloud the fact that over their lifetimes, few physicists, if any, have surmounted this impedance mismatch more effectively than Julian, conveying not only knowledge but lofty values and aspirations directly and indirectly to thousands of physicists…

  12. Two photon physics. Personal recollection

    CERN Document Server

    Ginzburg, Ilya F

    2015-01-01

    The term two--photon processes is used for the reactions in which some system of particles is produced in collision of two photons, either real or virtual. In the study of these processes our main goal was to suggest approach, allowing to extract from the data information on proper two--photon process separating it from mechanism which responsible for the production of photons. Here I present my view for history of two--photon physics. I don't try to give complete review, concentrating mainly on works of our team (which cover essential part of the topic) and some colleagues. My citation is strongly incomplete. I cite here only papers which were essential in our understanding of the problems. The choice of presented details is the result of my discussions with Gleb Kotkin and Valery Serbo. 1. Prehistory. 2. Two photon processes at e^+e^- colliders. 3. Photon colliders. 4. Notes on physical program.

  13. Recollections of My Young Days

    Science.gov (United States)

    MITSUOKA, Tomotari

    2013-01-01

    I was bashful by nature. In elementary school, I was enthusiastic about painting pictures, posters, and calligraphy, and making butterfly specimens and models. When I entered the middle school of Seikei Gakuen, I was fortunate to have good teachers and friends. Prof. Kusatao Nakamura taught us the “Preciousness of the pureness of heart”, which is the principle of my life. After World War II, school classes reopened. I was deeply moved by the lecture of botany by Prof. Fumio Maekawa, and had a notion that I should like to make research my lifework. I went to high school and had the worries of my life. During that time, it was the book Gakusei ni atau by Prof. Eijirou Kawai, and a speech by Prof. Tadao Yanaihara, that sustained my heart. In 1953, I entered the postgraduate course of the University of Tokyo, and received the guidance of Prof. Yuichi Ochi. This matter was decisive for my life. First of all, I developed a new medium, BL agar, for culturing intestinal bacteria, and then I discovered that Bifidus bacteria was one of the predominant organisms in human adults. This discovery became the basis of my research until today. For two years from 1964, I studied abroad in Germany and made good friends, to whom I owe an inestimable debt of gratitude. After returning to Japan, I discovered a number of rules governing the intestinal ecosystem. Thus, a new interdisciplinary field, intestinal bacteriology, was established. Subsequently, I discovered the health effects of fermented milks and oligosaccharides and proposed “biogenics”. I firmly believe that the fruit of creation is granted as a result of endeavoring with a pure heart. PMID:24936370

  14. Freedom of Speech: A Clear and Present Need to Teach. ERIC Report.

    Science.gov (United States)

    Boileau, Don M.

    1983-01-01

    Presents annotations of 21 documents in the ERIC system on the following subjects: (1) theory of freedom of speech; (2) theorists; (3) research on freedom of speech; (4) broadcasting and freedom of speech; and (5) international questions of freedom of speech. (PD)

  15. Targeting U. S. Technologies: A Trend Analysis of Cleared Industry Reporting

    Science.gov (United States)

    2013-01-01

    do not constitute facts nor provide proof, nor do they represent empirically based certainty or knowledge. Some analytical judgments are based...Greece Holy See Hungary Iceland Ireland Italy Kosovo Latvia Liechtenstein Lithuania Luxembourg Macedonia Malta Moldova Monaco Montenegro Netherlands

  16. Young Children's Oral Language Proficiency and Reading Ability in Spanish and English. CLEAR Technical Report Series.

    Science.gov (United States)

    Padilla, Amado M.; And Others

    Seventy-one subjects (22 English monolinguals, 23 Spanish monolinguals, and one bilingual group comprised of 19 Spanish-dominant and 7 English-dominant bilinguals) were assessed by means of the Woodcock-Johnson Psycho-Educational Battery and the Woodcock-Johnson Language Proficiency Battery at the beginning of kindergarten and first grade. These…

  17. Freedom of Speech: A Clear and Present Need to Teach. ERIC Report.

    Science.gov (United States)

    Boileau, Don M.

    1983-01-01

    Presents annotations of 21 documents in the ERIC system on the following subjects: (1) theory of freedom of speech; (2) theorists; (3) research on freedom of speech; (4) broadcasting and freedom of speech; and (5) international questions of freedom of speech. (PD)

  18. Bridge Pressure Flow Scour at Clear Water Threshold Condition

    Institute of Scientific and Technical Information of China (English)

    GUO Junke; KERENYI Kornel; PAGAN-ORTIZ Jorge E; FLORA Kevin

    2009-01-01

    Bridge pressure flow scour at clear water threshold condition is studied theoretically and experimentally. The flume experiments reveal that the measured scour profiles under a bridge are more or less 2-dimensional; all the measured scour profiles can be described by two similarity equations, where the horizontal distance is scaled by the deck width while the local scour by the maximum scour depth; the maximum scour position is located just under the bridge about 15% deck width from the downstream deck edge; the scour begins at about one deck width upstream the bridge while the deposition occurs at about 2.5 deck widths downstream the bridge; and the maximum scour depth decreases with increas-ing sediment size, but increases with deck inundation. The theoretical analysis shows that: bridge scour can be divided into three cases, i.e. downstream unsubmerged, partially submerged, and totally submerged. For downstream unsubmerged flows, the maximum bridge scour depth is an open-channel problem where the conventional methods in terms of critical velocity or bed shear stress can be applied; for partially and totally submerged flows, the equilibrium maximum scour depth can be described by a scour and an inundation similarity number, which has been confirmed by experiments with two decks and two sediment sizes. For application, a design and field evaluation procedure with examples is presented, including the maximum scour depth and scour profile.

  19. Clearing Unexploded Ordnance: Bayesian Methodology for Assessing Success

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, K K.

    2005-10-30

    The Department of Defense has many Formerly Used Defense Sites (FUDS) that are slated for transfer for public use. Some sites have unexploded ordnance (UXO) that must be cleared prior to any land transfers. Sites are characterized using geophysical sensing devices and locations are identified where possible UXO may be located. In practice, based on the analysis of the geophysical surveys, a dig list of N suspect locations is created for a site that is possibly contaminated with UXO. The suspect locations on the dig list are often assigned into K bins ranging from ``most likely to contain UXO" to ``least likely to be UXO" based on signal discrimination techniques and expert judgment. Usually all dig list locations are sampled to determine if UXO is present before the site is determined to be free of UXO. While this method is 100% certain to insure no UXO remains in the locations identified by the signal discrimination and expert judgment, it is very costly. This paper proposes a statistical Bayesian methodology that may result in digging less than 100% of the suspect locations to reach a pre-defined tolerable risk, where risk is defined in terms of a low probability that any UXO remains in the unsampled dig list locations. Two important features of a Bayesian approach are that it can account for uncertainties in model parameters and that it can handle data that becomes available in stages. The results from each stage of data can be used to direct the subsequent digs.

  20. Energy Efficient Clear Channel Assessment for LR-WPAN

    Directory of Open Access Journals (Sweden)

    Praveen Kaushik

    2011-05-01

    Full Text Available IEEE 802.15.4 LR-WPAN is a specification for low-cost, low-powered and low data rate transmission. This standard uses CSMA/CA protocol for contention resolution. One of the tasks performed by CSMA/CA algorithm is Clear Channel Assessment (CCA, used to find the status (IDLE or BUSY of the channel. There are three operating modes to perform CCA. As per the standard CCA mode 2 and 3 are based on carrier sensing where as CCA mode 1 is based on Energy Detection Threshold (EDThreshold. CCA in most of the WPAN is based on carrier sense. EDThreshold dependent CCA mode 1 is more advantageous in case of energy constraint networks, as minimum energy is consumed in channel allocation using EDThreshold. This property of EDThreshold is utilized in CCA for LR- WPAN and is implemented in NS2. Simulation results of EDThreshold based mode 1 CCA indicate that number of packets dropped decreases, network as well as node throughput increases and energy consumption is also less when compared to Carrier Sense Threshold (CSThreshold based mode 1 CCA. It is also observed from the results that MAC_PACKET_ERROR is also acceptable, that is, less than 1%.

  1. A crystal-clear zebrafish for in vivo imaging.

    Science.gov (United States)

    Antinucci, Paride; Hindges, Robert

    2016-01-01

    The larval zebrafish (Danio rerio) is an excellent vertebrate model for in vivo imaging of biological phenomena at subcellular, cellular and systems levels. However, the optical accessibility of highly pigmented tissues, like the eyes, is limited even in this animal model. Typical strategies to improve the transparency of zebrafish larvae require the use of either highly toxic chemical compounds (e.g. 1-phenyl-2-thiourea, PTU) or pigmentation mutant strains (e.g. casper mutant). To date none of these strategies produce normally behaving larvae that are transparent in both the body and the eyes. Here we present crystal, an optically clear zebrafish mutant obtained by combining different viable mutations affecting skin pigmentation. Compared to the previously described combinatorial mutant casper, the crystal mutant lacks pigmentation also in the retinal pigment epithelium, therefore enabling optical access to the eyes. Unlike PTU-treated animals, crystal larvae are able to perform visually guided behaviours, such as the optomotor response, as efficiently as wild type larvae. To validate the in vivo application of crystal larvae, we performed whole-brain light-sheet imaging and two-photon calcium imaging of neural activity in the retina. In conclusion, this novel combinatorial pigmentation mutant represents an ideal vertebrate tool for completely unobstructed structural and functional in vivo investigations of biological processes, particularly when imaging tissues inside or between the eyes.

  2. Clear antismudge unimolecular coatings of diblock copolymers on glass plates.

    Science.gov (United States)

    Macoretta, Danielle; Rabnawaz, Muhammad; Grozea, Claudia M; Liu, Guojun; Wang, Yu; Crumblehulme, Alison; Wyer, Martin

    2014-12-10

    Two poly[3-(triisopropyloxysilyl)propyl methacrylate]-block-poly[2-(perfluorooctyl)ethyl methacrylate] (PIPSMA-b-PFOEMA) samples and one poly(perfluoropropylene oxide)-block-poly-[3-(triisopropyloxysilyl)propyl methacrylate] (PFPO-b-PIPSMA) sample were synthesized, characterized, and used to coat glass plates. These coatings were formed by evaporating a dilute polymer solution containing HCl, which catalyzed PIPSMA's sol-gel chemistry. Polymer usage was minimized by targeting at diblock copolymer unimolecular (brush) layers that consisted of a sol-gelled grafted PIPSMA layer and an oil- and water-repellant fluorinated surface layer. Investigated is the effect of varying the catalyst amount, polymer amount, as well as block copolymer type and composition on the structure, morphology, and oil- and water-repellency of the coatings. Under optimized conditions, the prepared coatings were optically clear and resistant to writing by a permanent marker. The marker's trace was the faintest on PFPO-b-PIPSMA coatings. In addition, the PFPO-b-PIPSMA coatings were far more wear-resistant than the PIPSMA-b-PFOEMA coatings.

  3. Clearing the way for reducing emissions from tropical deforestation

    Energy Technology Data Exchange (ETDEWEB)

    Skutsch, M. [Department of Technology and Sustainable Development, University of Twente, P.O. Box 217, 7500 AE Enschede (Netherlands); Bird, N. [Joanneum Research, Elizabethstrasse 5/1, A-8010 Graz (Austria); Trines, E. [Gramserweg 2, 3711 AW Austerlitz (Netherlands); Dutschke, M. [Biocarbon, Badstrasse 41, 77652 Offenburg (Germany); Frumhoff, P. [Union of Concerned Scientists, 2 Brattle Square, Cambridge, MA 02238-9105 (United States); De Jong, B.H.J. [El Colegio de la Frontera Sur, Unidad Villahermosa, Carr. Vhsa-Reforma Km. 15.5, C.P. 86280, Ra Guineo 2da Secc, Villahermosa, Tabasco (Mexico); Van Laak, P. [ITC, Department of Natural Resources, P.O. Box 6, 7500 AA Enschede (Netherlands); Masera, O. [Centro de Investigaciones en Ecosistemas, UNAMAP 27-3 Xangari 58089, Morelia, Michoacan (Mexico); Murdiyarso, D. [Center for International Forestry Research, Jl. CIFOR, Situ Gede Sindangbarang, Bogor 16680 (Indonesia)

    2007-06-15

    Carbon emissions from tropical deforestation account for about 25% of all anthropogenic carbon dioxide emissions but cannot be credited under current climate change agreements. In the discussions around the architecture of the post-2012 climate regime, the possibility of including credits for reduced emissions from deforestation arises. The paper reviews two approaches for this, compensated reductions (CR) as proposed by Santilli et al. and the Joint Research Centre proposal that combine voluntary commitments by non-Annex I countries to reduce emissions from deforestation with carbon market financing. Both approaches have the clear advantages of simplicity and the possibility of fitting to an evolving greenhouse gas emission reduction regime. The authors consider the strengths and limitations of each proposal and build upon them to address several implementation challenges and options for improvement. Given the urgency of avoiding dangerous climate change, the timely development of technically sound, politically acceptable, cost-effective and practicable measures to reduce emissions from deforestation and forest degradation is essential. These two approaches take us a step closer to this goal, but they need to be refined rapidly to enable this goal to be realised.

  4. Report

    Directory of Open Access Journals (Sweden)

    Akin Aydogan

    2012-01-01

    Full Text Available Introduction. Gossypiboma (GP is a term used to express the mass resulting from forgotten cotton sponge in operations. Rarely, a transmural migration may occur into the gastrointestinal lumen without creating any defect by GP. Laparotomy or endoscopic removal may be required, by the way it can be taken out of the body itself by intestinal ways. In this study, we reported a case of mechanical intestinal obstruction causing GP. Case. The fifty-one-year-old female patient admitted to the emergency department with the complaints of mechanical intestinal obstruction and had a history of open cholecystectomy 20 years ago. There were the findings of intestinal obstruction in abdominal plain radiography and computerized tomography. The sponge that obstructed the lumen completely 40 cm proximal to the ileocecal valve was identified in the laparotomy with the diagnosis of brid ileus. The small intestine was closed over double-fold after removal of sponge. Transmural migration of abdominal-remained sponge was thought to be occurred without creating a defect after cholecystectomy. Postoperatively, the patient was discharged without having any problems at 4th day of hospitalization. Conclusion. Although it is a rare situation in routine clinical practice, GP should be considered as a differential diagnosis in the patients who had a diagnosis of mechanical intestinal obstruction, and laparotomy was applied before. As GP may lead to situations which cause mortality, all precautions should be taken to prevent it.

  5. Pediatric intracranial clear cell meningioma associated with a germline mutation of SMARCE1: a novel case.

    Science.gov (United States)

    Raffalli-Ebezant, Helen; Rutherford, Scott A; Stivaros, Stavros; Kelsey, Anna; Smith, Miriam; Evans, D Gareth; Kilday, John-Paul

    2015-03-01

    Intracranial clear cell meningioma (CCM) represents a rare and potentially more aggressive subgroup of meningioma that is observed more frequently in children and adolescents. Despite its characterization as a histological entity, there is little evidence identifying tumorigenic etiologies. Recently, a novel mutation in SMARCE1, encoding a subunit of the SWI/SNF chromatin remodeling complex, was identified in a cohort of spinal CCMs. To date, no intracranial CCM has been subjected to analysis. We report the case of an isolated intracranial CCM in a 14-year-old girl. Gross total resection was achieved following a two-stage approach with no evidence of tumor recurrence 8 months following presentation. Exon sequencing identified a germline mutation in SMARCE1, which was also present in tumor DNA. Extensive literature review confirmed our study is the first to seek and report a genetic anomaly for childhood intracranial CCMs outside of the NF2 gene locus, and the first to make an association between a germline SMARCE1 mutation and childhood intracranial CCMs. Together with the previous description of SMARCE1 mutations in spinal CCMs, our report suggests that SMARCE1 aberrations may be implicated in establishing a clear cell histology irrespective of meningioma location. We would advocate that, where feasible, genetic sequencing is performed on future new cases of childhood neuraxial CCMs and includes interrogation of the SMARCE1 gene.

  6. NOAA AVHRR Clear-Sky Products over Oceans (ACSPO): Sea Surface Temperature, Clear Sky Radiances, and Aerosol Optical Depth for the Global Ocean, 2011 - present (NCEI Accession 0072979)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The AVHRR Clear-Sky Processor over Oceans, jointly developed between NESDIS STAR and OSDPD, produces AVHRR clear-sky products over oceans. ACSPO generates output...

  7. Gene expression profile of renal cell carcinoma clear cell type

    Directory of Open Access Journals (Sweden)

    Marcos F. Dall’Oglio

    2010-08-01

    Full Text Available PURPOSE: The determination of prognosis in patients with renal cell carcinoma (RCC is based, classically, on stage and histopathological aspects. The metastatic disease develops in one third of patients after surgery, even in localized tumors. There are few options for treating those patients, and even the new target designed drugs have shown low rates of success in controlling disease progression. Few studies used high throughput genomic analysis in renal cell carcinoma for determination of prognosis. This study is focused on the identification of gene expression signatures in tissues of low-risk, high-risk and metastatic RCC clear cell type (RCC-CCT. MATERIALS AND METHODS: We analyzed the expression of approximately 55,000 distinct transcripts using the Whole Genome microarray platform hybridized with RNA extracted from 19 patients submitted to surgery to treat RCC-CCT with different clinical outcomes. They were divided into three groups (1 low risk, characterized by pT1, Fuhrman grade 1 or 2, no microvascular invasion RCC; (2 high risk, pT2-3, Fuhrman grade 3 or 4 with, necrosis and microvascular invasion present and (3 metastatic RCC-CCT. Normal renal tissue was used as control. RESULTS: After comparison of differentially expressed genes among low-risk, high-risk and metastatic groups, we identified a group of common genes characterizing metastatic disease. Among them Interleukin-8 and Heat shock protein 70 were over-expressed in metastasis and validated by real-time polymerase chain reaction. CONCLUSION: These findings can be used as a starting point to generate molecular markers of RCC-CCT as well as a target for the development of innovative therapies.

  8. Managed Clearings: an Unaccounted Land-cover in Urbanizing Regions

    Science.gov (United States)

    Singh, K. K.; Madden, M.; Meentemeyer, R. K.

    2016-12-01

    Managed clearings (MC), such as lawns, public parks and grassy transportation medians, are a common and ecologically important land cover type in urbanizing regions, especially those characterized by sprawl. We hypothesize that MC is underrepresented in land cover classification schemes and data products such as NLCD (National Land Cover Database) data, which may impact environmental assessments and models of urban ecosystems. We visually interpreted and mapped fine scale land cover with special attention to MC using 2012 NAIP (National Agriculture Imagery Program) images and compared the output with NLCD data. Areas sampled were 50 randomly distributed 1*1km blocks of land in three cities of the Char-lanta mega-region (Atlanta, Charlotte, and Raleigh). We estimated the abundance of MC relative to other land cover types, and the proportion of land-cover types in NLCD data that are similar to MC. We also assessed if the designations of recreation, transportation, and utility in MC inform the problem differently than simply tallying MC as a whole. 610 ground points, collected using the Google Earth, were used to evaluate accuracy of NLCD data and visual interpretation for consistency. Overall accuracy of visual interpretation and NLCD data was 78% and 58%, respectively. NLCD data underestimated forest and MC by 14.4km2 and 6.4km2, respectively, while overestimated impervious surfaces by 10.2km2 compared to visual interpretation. MC was the second most dominant land cover after forest (40.5%) as it covered about 28% of the total area and about 13% higher than impervious surfaces. Results also suggested that recreation in MC constitutes up to 90% of area followed by transportation and utility. Due to the prevalence of MC in urbanizing regions, the addition of MC to the synthesis of land-cover data can help delineate realistic cover types and area proportions that could inform ecologic/hydrologic models, and allow for accurate prediction of ecological phenomena.

  9. DISCRIMINATING BETWEEN CLOUDY, HAZY, AND CLEAR SKY EXOPLANETS USING REFRACTION

    Energy Technology Data Exchange (ETDEWEB)

    Misra, Amit K.; Meadows, Victoria S. [Astronomy Department, University of Washington, Seattle, WA 98195 (United States)

    2014-11-01

    We propose a method to distinguish between cloudy, hazy, and clear sky (free of clouds and hazes) exoplanet atmospheres that could be applicable to upcoming large aperture space- and ground-based telescopes such as the James Webb Space Telescope (JWST) and the European Extremely Large Telescope (E-ELT). These facilities will be powerful tools for characterizing transiting exoplanets, but only after a considerable amount of telescope time is devoted to a single planet. A technique that could provide a relatively rapid means of identifying haze-free targets (which may be more valuable targets for characterization) could potentially increase the science return for these telescopes. Our proposed method utilizes broadband observations of refracted light in the out-of-transit spectrum. Light refracted through an exoplanet atmosphere can lead to an increase of flux prior to ingress and subsequent to egress. Because this light is transmitted at pressures greater than those for typical cloud and haze layers, the detection of refracted light could indicate a cloud- or haze-free atmosphere. A detection of refracted light could be accomplished in <10 hr for Jovian exoplanets with JWST and <5 hr for super-Earths/mini-Neptunes with E-ELT. We find that this technique is most effective for planets with equilibrium temperatures between 200 and 500 K, which may include potentially habitable planets. A detection of refracted light for a potentially habitable planet would strongly suggest the planet was free of a global cloud or haze layer, and therefore a promising candidate for follow-up observations.

  10. Magnetogram Forecast: An All-Clear Space Weather Forecasting System

    Science.gov (United States)

    Barghouty, Nasser; Falconer, David

    2015-01-01

    Solar flares and coronal mass ejections (CMEs) are the drivers of severe space weather. Forecasting the probability of their occurrence is critical in improving space weather forecasts. The National Oceanic and Atmospheric Administration (NOAA) currently uses the McIntosh active region category system, in which each active region on the disk is assigned to one of 60 categories, and uses the historical flare rates of that category to make an initial forecast that can then be adjusted by the NOAA forecaster. Flares and CMEs are caused by the sudden release of energy from the coronal magnetic field by magnetic reconnection. It is believed that the rate of flare and CME occurrence in an active region is correlated with the free energy of an active region. While the free energy cannot be measured directly with present observations, proxies of the free energy can instead be used to characterize the relative free energy of an active region. The Magnetogram Forecast (MAG4) (output is available at the Community Coordinated Modeling Center) was conceived and designed to be a databased, all-clear forecasting system to support the operational goals of NASA's Space Radiation Analysis Group. The MAG4 system automatically downloads nearreal- time line-of-sight Helioseismic and Magnetic Imager (HMI) magnetograms on the Solar Dynamics Observatory (SDO) satellite, identifies active regions on the solar disk, measures a free-energy proxy, and then applies forecasting curves to convert the free-energy proxy into predicted event rates for X-class flares, M- and X-class flares, CMEs, fast CMEs, and solar energetic particle events (SPEs). The forecast curves themselves are derived from a sample of 40,000 magnetograms from 1,300 active region samples, observed by the Solar and Heliospheric Observatory Michelson Doppler Imager. Figure 1 is an example of MAG4 visual output

  11. Effect of mechanical optical clearing on near-infrared spectroscopy.

    Science.gov (United States)

    Idelson, Christopher R; Vogt, William C; King-Casas, Brooks; LaConte, Stephen M; Rylander, Christopher G

    2015-08-01

    Near-infrared Spectroscopy (NIRS) is a broadly utilized technology with many emerging applications including clinical diagnostics, sports medicine, and functional neuroimaging, to name a few. For functional brain imaging NIR light is delivered at multiple wavelengths through the scalp and skull to the brain to enable spatial oximetry measurements. Dynamic changes in brain oxygenation are highly correlated with neural stimulation, activation, and function. Unfortunately, NIRS is currently limited by its low spatial resolution, shallow penetration depth, and, perhaps most importantly, signal corruption due to light interactions with superficial non-target tissues such as scalp and skull. In response to these issues, we have combined the non-invasive and rapidly reversible method of mechanical tissue optical clearing (MOC) with a commercially available NIRS system. MOC utilizes a compressive loading force on tissue, causing the lateral displacement of blood and water, while simultaneously thinning the tissue. A MOC-NIRS Breath Hold Test displayed a ∼3.5-fold decrease in the time-averaged standard deviation between channels, consequentially promoting greater channel agreement. A Skin Pinch Test was implemented to negate brain and muscle activity from affecting the recorded signal. These results displayed a 2.5-3.0 fold increase in raw signal amplitude. Existing NIRS instrumentation has been further integrated within a custom helmet device to provide a uniform force distribution across the NIRS sensor array. These results showed a gradual decrease in time-averaged standard deviation among channels with an increase in applied pressure. Through these experiments, and the development of the MOC-NIRS helmet device, MOC appears to provide enhancement of NIRS technology beyond its current limitations.

  12. A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry

    Directory of Open Access Journals (Sweden)

    Shin-ichi Nakatsuka

    2012-01-01

    Full Text Available Carcinomas rarely arise from the urethral diverticulum. In this report, we present a case of clear cell adenocarcinoma arising from the urethral diverticulum. A 42-year-old woman complained of bloody discharge and lower back pain. Imaging studies showed a tumor involving the region surrounding the urethra and cystourethroscopy showed papillary and villous tumors in the urethral diverticula. Cytology of the urine sediment showed papillary or spherical clusters of atypical cells, some of which had clear abundant cytoplasm and formed mirror ball-like clusters, suggesting adenocarcinoma. Although histological diagnosis was indeterminate by biopsy and transurethral resection (TUR because of absence of stromal invasion, surgically resected specimen via cysturethrectomy revealed that the tumor was clear cell carcinoma. Urinary cytological findings and immunohistochemical analysis for CD15, Ki-67, and p53 might be useful for accurate diagnosis of clear cell adenocarcinoma that arises from the urethral diverticulum when sufficient materials are not available by biopsy and TUR.

  13. Super-Resolution Mapping of Neuronal Circuitry With an Index-Optimized Clearing Agent

    Directory of Open Access Journals (Sweden)

    Meng-Tsen Ke

    2016-03-01

    Full Text Available Super-resolution imaging deep inside tissues has been challenging, as it is extremely sensitive to light scattering and spherical aberrations. Here, we report an optimized optical clearing agent for high-resolution fluorescence imaging (SeeDB2. SeeDB2 matches the refractive indices of fixed tissues to that of immersion oil (1.518, thus minimizing both light scattering and spherical aberrations. During the clearing process, fine morphology and fluorescent proteins were highly preserved. SeeDB2 enabled super-resolution microscopy of various tissue samples up to a depth of >100 μm, an order of magnitude deeper than previously possible under standard mounting conditions. Using this approach, we demonstrate accumulation of inhibitory synapses on spine heads in NMDA-receptor-deficient neurons. In the fly medulla, we found unexpected heterogeneity in axon bouton orientations among Mi1 neurons, a part of the motion detection circuitry. Thus, volumetric super-resolution microscopy of cleared tissues is a powerful strategy in connectomic studies at synaptic levels.

  14. Chronic lymphocytic lymphoma and concomitant renal cell carcinoma (Clear Cell Type: Review of the literature

    Directory of Open Access Journals (Sweden)

    Burak Uz

    2016-01-01

    Full Text Available In the present report, a 73 years-old male patient who developed clear cell type renal cell carcinoma (RCC 5 years after the diagnosis of chronic lymphocytic lymphoma (CLL and plausible explanations for this association were discussed by the authors. The incidence of CLL and RCC occurring in the same patient is higher than that expected in the general population. Various explicative hypotheses of this concurrence include treatment-related development of a second malignancy, immunomodulatory mechanisms, viral aetiology, cytokine (interleukin 6 release from a tumor, and common genetic mutations. Further investigations are warranted.

  15. Flight Tests of the DELICAT Airborne LIDAR System for Remote Clear Air Turbulence Detection

    Directory of Open Access Journals (Sweden)

    Vrancken Patrick

    2016-01-01

    Full Text Available An important aeronautics application of lidar is the airborne remote detection of Clear Air Turbulence which cannot be performed with onboard radar. We report on a DLR-developed lidar system for the remote detection of such turbulent areas in the flight path of an aircraft. The lidar, consisting of a high-power UV laser transmitter and a direct detection system, was installed on a Dutch research aircraft. Flight tests executed in 2013 demonstrated the performance of the lidar system to detect local subtle variations in the molecular backscatter coefficient indicating the turbulence some 10 to 15 km ahead.

  16. [Clear-cell sarcoma of the kidney: about a paediatric case].

    Science.gov (United States)

    Namaoui, R Y; Castex, M P; Vial, J; Galinier, P; Rubie, H; Laprie Mazieres, A; Le Mandat, A; Brousset, P; Delsol-Tahou, M

    2010-06-01

    Clear-cell sarcoma of the kidney (CCSK) is a rare malignant tumor of childhood, known for its aggressiveness, its tendency to recurrence and to metastasis to bone. We report an observation of a child of 48 months carrying a large abdominal mass. The diagnosis of the SCCR was made on biopsy, since imaging remained uncertain as to the renal origin of the mass. Indeed, our observation underlines the difficulty of its diagnosis. Excepting the morphological aspect, there is no criterion for its recognition. Its prognosis has been improved by the new treatments.

  17. 77 FR 6335 - Protection of Cleared Swaps Customer Contracts and Collateral; Conforming Amendments to the...

    Science.gov (United States)

    2012-02-07

    ... merchants (``FCMs'') and derivatives clearing organizations (``DCOs'') regarding the treatment of cleared... the rules or bylaws of a derivatives clearing organization require that such transactions, along with the money, securities, and other property margining, guaranteeing or securing such transactions,...

  18. Acanthosis Nigricans associated with clear-cell renal cell carcinoma

    Science.gov (United States)

    Narvaez, Margarita Rosa Aveiga; Reis, Paola Vasconcellos Soares; Gomes, Augusto Cesar Marins; Paraskevopoulos, Daniela Kallíope de Sá; Santana, Frederico; Fugita, Oscar Eduardo Hidetoshi

    2016-01-01

    Acanthosis nigricans (AN), an entity recognized since the 19th century, is a dermatopathy associated with insulin-resistant conditions, endocrinopathies, drugs, chromosome abnormalities and neoplasia. The latter, also known as malignant AN, is mostly related to abdominal neoplasms. Malignant AN occurs frequently among elderly patients. In these cases, the onset is subtle, and spreading involves the flexural regions of the body, particularly the axillae, palms, soles, and mucosa. Gastric adenocarcinoma is the most frequent associated neoplasia, but many others have been reported. Renal cell carcinoma (RCC), although already reported, is rarely associated with malignant AN. The authors report the case of a woman who was being treated for depression but presented a long-standing and marked weight loss, followed by darkening of the neck and the axillary regions. Physical examination disclosed a tumoral mass in the left flank and symmetrical, pigmented, velvety, verrucous plaques on both axillae, which is classical for AN. The diagnostic work-up disclosed a huge renal mass, which was resected and further diagnosed as a RCC. The post-operative period was uneventful and the skin alteration was evanescent at the first follow-up consultation. The authors call attention to the association of AN with RCC. PMID:27284539

  19. Madeleine Leininger: claroscuro trascultural Madeleine Leininger: Clear and dark transcultural

    Directory of Open Access Journals (Sweden)

    David Fornons Fontdevila

    2010-09-01

    Full Text Available A principios de la década de los años 60, Madeleine Leininger conceptualiza y funda la Enfermería transcultural, pero a pesar de la vigencia y reconocimiento que actualmente posee la enfermería transcultural, ésta no se escapa de un territorio claro-oscuro de contradicciones y dicciones. ¿Qué concepto de cultura utiliza Madeleine Leininger? ¿Qué consecuencias implica su transculturalidad? En el artículo se debate la particularidad conceptual utilizada por Leininger. Así mismo se propone cambiar terminológicamente y conceptualmente significados y significantes como la etnoenfermería y los conceptos de transculturalidad que a ella refieren. Para evitar los determinismos culturales se considera más correcto hablar de las identidades culturales, propias e individuales. La enfermería debe establecer un diálogo transcultural con las identidades culturales, con las medicinas y enfermerías transculturales. Un diálogo en igualdad, no sin por ello renunciar a la riqueza y eficiencia de la enfermería y de la medicina occidentales.At the beginning of the decade of the 60s, Madeleine Leininger conceptualizes and founds the nursing transcultural, but in spite of the current force and recognition that nowadays possesses the nursing transcultural, this does not escape of a clear - dark territory of contradictions and dictions. What concept of culture does Madeleine Leininger use? What consequences does it imply her transculturality? In the article the conceptual particularity used by Leininger is debated. Likewise it proposes to change the term and conceptual important and significant as the etno-infirmary and the concepts of transcultural that recount her. To avoid the cultural determinisms it is more correct to speak about the cultural, own and individual identities. The nursing must establish a dialog transcultural with the cultural identities, with the medicines and transcultural nursing. A dialog in equality, not without for it to resign

  20. Stony Brook's Graduate Courses in Clear, Vivid, Conversational Communication

    Science.gov (United States)

    Bass, E.

    2011-12-01

    Graduate students in the sciences at Stony Brook University are taking for-credit courses to learn to communicate more effectively about science with people outside their disciplines, including public officials, the press, students, potential funders and employers, colleagues in other fields, and the general public. Five Communicating Science courses are offered; two more will be added in January, 2012. The courses are offered by the School of Journalism and developed by the Center for Communicating Science (CCS). This interdisciplinary center was founded in 2009, with the participation of Alan Alda, the actor, writer, director and longtime advocate for science, who is a Visiting Professor at Stony Brook. At the core of the program are three 1-credit (14-hour) modules that rely on experiential learning, repeated practice and immediate, interactive feedback. In Distilling Your Message, students practice speaking clearly, vividly and conversationally about their work at different levels of complexity and formality to different audiences, using storytelling techniques where appropriate. In Writing for the Public, they extend these skills into writing. In Improvisation for Scientists, the most unconventional of the courses, students play improvisational theater games to help themselves connect more directly, personally and responsively with their audiences. In their first two semesters, the courses are expected to serve about 90 students, taking a total of about 180 credits. Most of the courses have filled quickly, mixing master's and doctoral students from more than a dozen fields, including marine and atmospheric sciences. Three to six credits of Communicating Science courses are required for students in two programs, an MA in Marine Conservation and Policy and an Advanced Certificate in Health Communications. The content and methods of the courses are based largely on lessons learned from evaluations of all-day workshops that CCS has conducted for more than 250

  1. Environmental Assessment for Clear AFS Grid Tie-in and Heat Plant, Clear Air Force Station, Alaska

    Science.gov (United States)

    2013-07-01

    The equipment used would not produce greater noise volumes than other activities typical for the area. The CHPP operation produces a constant drone ...purposes of this report, geologic resources include geology, topography , and soils. Prime farmland is protected under the Farmland Protection Policy Act...pollutants emitted into the atmosphere, the size and topography of the air basin (in particular, features such as mountains or valleys which may inhibit

  2. Clear sky visibility has decreased over land globally from 1973 to 2007.

    Science.gov (United States)

    Wang, Kaicun; Dickinson, Robert E; Liang, Shunlin

    2009-03-13

    Visibility in the clear sky is reduced by the presence of aerosols, whose types and concentrations have a large impact on the amount of solar radiation that reaches Earth's surface. Here we establish a global climatology of inverse visibilities over land from 1973 to 2007 and interpret it in terms of changes in aerosol optical depth and the consequent impacts on incident solar radiation. The aerosol contribution to "global dimming," first reported in terms of strong decreases in measured incident solar radiation up to the mid-1980s, has monotonically increased over the period analyzed. Since that time, visibility has increased over Europe, consistent with reported European "brightening," but has decreased substantially over south and east Asia, South America, Australia, and Africa, resulting in net global dimming over land.

  3. Unusual Ultrasound Presentation of Testicular Metastasis from Renal Clear Cell Carcinoma

    Science.gov (United States)

    Dell’Atti, Lucio

    2016-01-01

    Testicular metastases from renal clear cell carcinoma (RCC) are extremely uncommon. To the best of our knowledge, only 32 cases have been reported in the literature. We report a rare case of testicular metastasis from RCC. A 69-year-old patient presented with discomfort and pain in his left testis. He had undergone laparoscopic left radical nephrectomy at another institution. Scrotal ultrasonography revealed a non-palpable lesion at the upper pole of the left testis with hypoechoic aspect, highly suspicious for malignancy. We performed a left inguinal orchiectomy. The testicular lesion was diagnosed as a metastasis from RCC. After orchiectomy, a computed tomography of the chest and abdomen revealed no other metastatic lesions. The patient remains free of clinical recurrence after 20 months without adjuvant therapy.

  4. Clear Cell Atypical Fibroxanthoma: Clinicopathological Study of 6 Cases and Review of the Literature With Special Emphasis on the Differential Diagnosis.

    Science.gov (United States)

    Tardío, Juan C; Pinedo, Fernando; Aramburu, José Antonio; Martínez-González, Miguel Á; Arias, Dolores; Khedaoui, Radia; Suárez-Massa, Dolores; Santonja, Carlos

    2016-08-01

    Atypical fibroxanthoma (AFX) is an uncommon dermal-based neoplasm arising on the sun-damaged skin of elderly people. Clear cell AFX is a rare variant with only 12 cases reported until the present date, all of them as case reports, except for 1 small series of 3 cases. The authors report 6 new cases and review the literature with special emphasis on the differential diagnosis. The clear cell variant represents 5% of AFX from their files. Histopathologically, it consists of sheets of epithelioid, pleomorphic cells, intermixed with a varying number of giant multinucleated and spindle cells, the latter arranged in a fascicular pattern. All cell types predominantly exhibit a clear, microvacuolated cytoplasm with well-demarcated cell borders. The clinical and immunohistochemical features of this variant are similar to those of the classic type. Clear cell AFX must be differentiated from other cutaneous clear cell neoplasms, some of them with an aggressive clinical behavior, including clear cell melanoma, primary cutaneous and metastatic clear cell carcinomas, clear cell sarcoma, pleomorphic liposarcoma, tumor of perivascular epithelioid cells, and distinctive dermal clear cell mesenchymal neoplasm. The clinical presentation and immunohistochemical profile play a key role in the differential diagnosis.

  5. A survey of clearing techniques for 3D imaging of tissues with special reference to connective tissue.

    Science.gov (United States)

    Azaripour, Adriano; Lagerweij, Tonny; Scharfbillig, Christina; Jadczak, Anna Elisabeth; Willershausen, Brita; Van Noorden, Cornelis J F

    2016-08-01

    For 3-dimensional (3D) imaging of a tissue, 3 methodological steps are essential and their successful application depends on specific characteristics of the type of tissue. The steps are 1° clearing of the opaque tissue to render it transparent for microscopy, 2° fluorescence labeling of the tissues and 3° 3D imaging. In the past decades, new methodologies were introduced for the clearing steps with their specific advantages and disadvantages. Most clearing techniques have been applied to the central nervous system and other organs that contain relatively low amounts of connective tissue including extracellular matrix. However, tissues that contain large amounts of extracellular matrix such as dermis in skin or gingiva are difficult to clear. The present survey lists methodologies that are available for clearing of tissues for 3D imaging. We report here that the BABB method using a mixture of benzyl alcohol and benzyl benzoate and iDISCO using dibenzylether (DBE) are the most successful methods for clearing connective tissue-rich gingiva and dermis of skin for 3D histochemistry and imaging of fluorescence using light-sheet microscopy.

  6. 78 FR 62846 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing...

    Science.gov (United States)

    2013-10-22

    ... Supplemental Liquidity Deposits to Its Clearing Fund Designed To Increase Liquidity Resources To Meet Its Liquidity Needs October 15, 2013. On March 21, 2013, National Securities Clearing Corporation (``NSCC...'') to provide for supplemental liquidity deposits to its Clearing Fund (the ``NSCC Clearing Fund'')...

  7. Measuring the effects of topically applied skin optical clearing agents and modeling the effects and consequences for laser therapies

    Science.gov (United States)

    Verkruysse, Wim; Khan, Misbah; Choi, Bernard; Svaasand, Lars O.; Nelson, J. Stuart

    2005-04-01

    Human skin prepared with an optical clearing agent manifests reduced scattering as a result of de-hydration and refractive index matching. This has potentially large effects for laser therapies of several skin lesions such as port wine stain, hair removal and tattoo removal. With most topically applied clearing agents the clearing effect is limited because they penetrate poorly through the intact superficial skin layer (stratum corneum). Agent application modi other than topical are impractical and have limited the success of optical clearing in laser dermatology. In recent reports, however, a mixture of lipofylic and hydrofylic agents was shown to successfully penetrate through the intact stratum corneum layer which has raised new interest in this field. Immediately after application, the optical clearing effect is superficial and, as the agent diffuses through the skin, reduced scattering is manifested in deeper skin layers. For practical purposes as well as to maximize therapeutic success, it is important to quantify the reduced scattering as well as the trans-cutaneous transport dynamics of the agent. We determined the time and tissue depth resolved effects of optically cleared skin by inserting a microscopic reflector array in the skin. Depth dependent light intensity was measured by quantifying the signal of the reflector array with optical coherence tomography. A 1-dimensional mass diffusion model was used to estimate a trans-cutaneous transport diffusion constant for the clearing agent mixture. The results are used in Monte Carlo modeling to determine the optimal time of laser treatment after topical application of the optical clearing agent.

  8. A Synchronous Pancreatic Metastasis from Renal Clear Cell Carcinoma, with Unusual CT Characteristics, Completely Regressed after Therapy with Sunitinib

    Directory of Open Access Journals (Sweden)

    Salvatore Lauro

    2014-01-01

    Full Text Available We present a case report of a 75-years-old woman affected by renal clear cell carcinoma with a synchronous pancreatic metastasis and a metachronous lung metastasis. This case has two peculiarities. First the pancreatic metastasis was treated just with medical therapy, that is, Sunitinib, instead of the surgical therapy that is mostly considered. Secondly, the pancreatic lesion showed different characteristics on the computed tomography scan compared to the usual pancreatic metastases from renal clear cell carcinoma. The pancreatic metastasis totally regressed after medical treatment and nowadays, four years after the diagnosis, the patient is disease-free.

  9. CLEAR Landscape Change Module: No Increased Restoration and Protection, UTM Zone 15N NAD83, Coastal Louisiana Ecosystem Assessment and Restoration (2007), [CLEAR_Output_NIA_012307_final

    Data.gov (United States)

    Louisiana Geographic Information Center — The Coastal Louisiana Ecosystem Assessment and Restoration (CLEAR) Framework is an integrated ecosystem forecasting system, designed to simulate ecological change...

  10. Final Radiological Assessment of External Exposure for CLEAR-Line Americium Recovery Operations

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Adam C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Belooussova, Olga N. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hetrick, Lucas Duane [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-11-12

    Los Alamos National Laboratory is currently planning to implement an americium recovery program. The americium, ordinarily isotopically pure 241Am, would be extracted from existing Pu materials, converted to an oxide and shipped to support fabrication of americium oxide-beryllium neutron sources. These operations would occur in the currently proposed Chloride Extraction and Actinide Recovery (CLEAR) line of glove boxes. This glove box line would be collocated with the currently-operational Experimental Chloride Extraction Line (EXCEL). The focus of this document is to provide an in-depth assessment of the currently planned radiation protection measures and to determine whether or not further design work is required to satisfy design-goal and ALARA requirements. Further, this document presents a history of americium recovery operations in the Department of Energy and high-level descriptions of the CLEAR line operations to provide a basis of comparison. Under the working assumptions adopted by this study, it was found that the evaluated design appears to mitigate doses to a level that satisfies the ALARA-in-design requirements of 10 CFR 835 as implemented by the Los Alamos National Laboratory procedure P121. The analyses indicate that extremity doses would also meet design requirements. Dose-rate calculations were performed using the radiation transport code MCNP5 and doses were estimated using a time-motion study developed in consort with the subject matter expert. A copy of this report and all supporting documentation are located on the Radiological Engineering server at Y:\\Rad Engineering\\2013 PROJECTS\\TA-55 Clear Line.

  11. Effects of a new type of clear overlay retainer on occlusal contacts.

    Science.gov (United States)

    Kim, Kyoung Yeon; Ahn, Hyo-Won; Kim, Seong-Hun; Nelson, Gerald

    2017-05-01

    The popularity of clear overlay retainers (CORs) has increased recently because of their advantages such as better esthetics, cost effectiveness, easy fabrication, and good compliance. However, a deficiency in posterior occlusal settling is a reported limitation of CORs. The aim of this study was to evaluate the posterior occlusal contact changes in a new type of clear orthodontic retainer called Oral-treaper (OTP), which consists of three layers and has stronger mechanical characteristics than do conventional retainers. Three patients who completed fixed orthodontic treatment received OTP as a removable retainer. Cast models were fabricated after the removal of fixed appliances (T1) and after 4 to 11 months of using the retainers (T2). We evaluated all the cast models to compare the post-orthodontic settling pattern during the use of the OTPs. The depth of occlusal contacts was evaluated using color maps. The OTP did not prevent vertical settling in all patients but resulted in an improvement in posterior occlusal contact points.

  12. Optical clearing of skin enhanced with hyaluronic acid for increased contrast of optoacoustic imaging

    Science.gov (United States)

    Liopo, Anton; Su, Richard; Tsyboulski, Dmitri A.; Oraevsky, Alexander A.

    2016-08-01

    Enhanced delivery of optical clearing agents (OCA) through skin may improve sensitivity of optical and optoacoustic (OA) methods of imaging, sensing, and monitoring. This report describes a two-step method for enhancement of light penetration through skin. Here, we demonstrate that topical application of hyaluronic acid (HA) improves skin penetration of hydrophilic and lipophilic OCA and thus enhances their performance. We examined the OC effect of 100% polyethylene and polypropylene glycols (PPGs) and their mixture after pretreatment by HA, and demonstrated significant increase in efficiency of light penetration through skin. Increased light transmission resulted in a significant increase of OA image contrast in vitro. Topical pretreatment of skin for about 30 min with 0.5% HA in aqueous solution offers effective delivery of low molecular weight OCA such as a mixture of PPG-425 and polyethylene glycol (PEG)-400. The developed approach of pretreatment by HA prior to application of clearing agents (PEG and PPG) resulted in a ˜47-fold increase in transmission of red and near-infrared light and significantly enhanced contrast of OA images.

  13. Preliminary juvenile Lost River and shortnose sucker investigations in Clear Lake, California--2011 pilot study summary

    Science.gov (United States)

    Burdick, Summer M.; Rasmussen, Josh

    2012-01-01

    Poor recruitment appears to limit the recovery of Lost River and shortnose sucker populations in Clear Lake Reservoir, California, but the cause is unknown. Adult suckers migrate up Willow Creek and its tributaries to spawn in some years, but low flow in Willow Creek may inhibit spawning migrations in other years. It is unclear whether spawning is successful, larvae survive, or juveniles persist to adulthood. Environmental variables associated with successful spawning or young-of-year survival have not been identified and early life history for these populations is poorly understood. The U.S. Geological Survey in cooperation with the U.S. Fish and Wildlife Service and Ruby Pipeline L.L.C. Corporation (El Paso, Tex.) initiated a study in 2011 to better understand juvenile sucker life history in Clear Lake Reservoir, and to identify constraints in the early life history that may limit recruitment to the adult spawning populations. This is a report on the 2011 pilot study for this project.

  14. Clear air boundary layer spaced antenna wind measurement with the Multiple Antenna Profiler (MAPR

    Directory of Open Access Journals (Sweden)

    S. A. Cohn

    Full Text Available Spaced antenna (SA wind measurement techniques are applied to Multiple Antenna Profiler (MAPR data to evaluate its performance in clear air conditions. MAPR is a multiple antenna 915 MHz wind profiler developed at the National Center for Atmospheric Research (NCAR and described in Cohn et al. (1997, designed to make high resolution wind measurements. Previous reported measurements with MAPR were restricted to precipitation because of low signal to noise (SNR and signal to ground-clutter (SCR ratios. By using a standard pulse-coding technique and upgrading the profiler control software, increases in average power and SNR were achieved, making routine measurements in clear air possible. Comparison of winds measured by MAPR and by a sonic anemometer on a nearby 300 m tower show correlation coefficients in the range of R2 = 0.75 – 0.80, and an average absolute error of ~ 1.4 m s - 1 . This compares favorably with the agreement typically found in wind profiler comparisons. We also consider the use of the parameter ah , which is related to the value of the cross-correlation function at its zero crossing. This parameter is a data quality indicator and possibly a key component in a ground clutter removal technique.

    Key words. Meteorology and atmospheric dynamics (mesoscale meteorology; instruments and techniques – Radio science (remote sensing

  15. Piloted "Well Clear" Performance Evaluation of Detect-and-Avoid Systems with Suggestive Guidance

    Science.gov (United States)

    Mueller, Eric R.; Santiago, Confesor; Watza, Spencer

    2016-01-01

    This study evaluated the performance of four prototype unmanned aircraft detect-and-avoid (DAA) display configurations, each with different informational elements driven by alerting and guidance algorithms. Sixteen unmanned aircraft pilots flew each combination of the display configurations, with half being given zero DAA surveillance sensor uncertainty and the other half experiencing errors that were comparable, and in some cases slightly better than, errors that were measured in DAA system flight tests. The displays that showed intruder alert information in altitude and heading bands had significantly fewer losses of well clear compared with alternative displays that lacked that information. This difference was significant from a statistical and practical perspective: those losses that did occur lasted for shorter periods and did not penetrate as far into the geometric "separation cylinder" as those in the non-banded displays. A modest level of DAA surveillance sensor uncertainty did not affect the proportion of losses of well clear or their severity. It is recommended that DAA traffic displays implement a band-type display in order to improve the safety of UAS operations in the National Airspace System. Finally, this report provides pilot response time distributions for responding to DAA alerts.

  16. Application of the Lighthill-Ford Theory of Spontaneous Imbalance to Clear-Air Turbulence Forecasting

    Science.gov (United States)

    Williams, Pd; Knox, Ja; McCann, Dw

    2009-09-01

    A new method of clear-air turbulence (CAT) forecasting based on the Lighthill-Ford theory of spontaneous imbalance and emission of inertia-gravity waves has been derived and applied on episodic and seasonal time scales. A scale analysis of this shallow-water theory for midlatitude synoptic-scale flows identifies advection of relative vorticity as the leading-order source term. Examination of leading- and second-order terms elucidates previous, more empirically inspired CAT forecast diagnostics. Application of the Lighthill-Ford theory to the Upper Mississippi and Ohio Valleys CAT outbreak of 9 March 2006 results in good agreement with pilot reports of turbulence. Application of Lighthill-Ford theory to CAT forecasting for the 3 November 2005-26 March 2006 period using 1-h forecasts of the Rapid Update Cycle (RUC) 2 1500 UTC model run leads to superior forecasts compared to the current operational version of the Graphical Turbulence Guidance (GTG1) algorithm, the most skillful operational CAT forecasting method in existence. The results suggest that major improvements in CAT forecasting could result if the methods presented herein become operational. Reference Knox, J.A., D.W. McCann, and P.D. Williams, 2008: Application of the Lighthill-Ford Theory of Spontaneous Imbalance to Clear-Air Turbulence Forecasting. J. Atmos. Sci., 65, 3292-3304.

  17. Clear cell renal cell carcinoma with hemangioblastoma-like features: A recently described pattern with unusual immunohistochemical profile

    Directory of Open Access Journals (Sweden)

    Sankalp Sancheti

    2015-01-01

    Full Text Available The diagnosis of clear cell renal cell carcinoma may sometimes pose challenges because of the presence of uncharacteristic morphology, varied immunophenotypic patterns and due to lack of molecular or genetic determinants. More often, the morphological variations can be easily overlooked in routine practice and a more common diagnosis is usually put forward. Solid, acinar and alveolar are the common patterns described in the literature. We report a recently described pattern of clear cell renal cell carcinoma which has hemangioblastoma-like morphology and an unusual immunoprofile. In our case, the tumor showed a diffuse hemangioblastoma-like pattern and diffuse positivity for Alpha-inhibin on immunohistochemistry. A thorough literature search, extensive sampling and an expanded immunohistochemistry panel revealed a clear cell renal cell carcinoma component. Presence of renal vein thrombosis and focal necrosis were other helpful features in discerning the malignant nature of tumor.

  18. Clear felling and burning effects on soil nitrogen transforming bacteria and actinomycetes population in Chittagong University campus, Bangladesh

    Institute of Scientific and Technical Information of China (English)

    S.M.Sirajul Haque; Rahima Ferdoshi; Sohag Miah; M.Nural Anwar

    2012-01-01

    The effect of forests clear felling and associated burning on the population of soil nitrogen transforming bacteria and actinomycetes are reported at three pair sites of Chittagong University campus,Bangladesh in monsoon tropical climate.Clear felled area or burnt site and 15-21 year mixed plantation of native and exotic species,situated side by side on low hill having Typic Dystrochrepts soil was represented at each pair site.At all the three pair sites,clear felled area or burnt site showed very significantly (p≤0.001) lower population of actinomycetes,Rhizobium,Nitrosomonas,Nitrobacter and ammonifying as well as denitrifying bacteria compared to their adjacent mixed plantation.From environmental consideration,this finding has implication in managing natural ecosystem.

  19. Metastatic clear cell carcinoma of the kidney: therapeutic role of bevacizumab.

    Science.gov (United States)

    Bukowski, Ronald M

    2010-03-26

    The biology and pathogenesis of clear cell carcinoma of the kidney has been extensively investgated, and the role of von Hipple-Landau gene inactivation and tumor associated angiogenesis is now recognized. Development of vascular endothelial growth factor inhibitors and phase 3 clinical trials utilizing this class of agents has produced a new treatment paradigm for patients with metastatic renal cell carcinoma (RCC). One of the active regimens identified is the combination of bevacizumab and interferon-α. Recently published reports provided evidence of the clinical and biologic activity of this therapy. The current manuscript reviews the background and rationale for the activity of bevacizumab in RCC, and results from recent clinical trials with this agent alone or in combination with targeted agents or cytokines. The role of this therapy in contrast to other targeted agents is reviewed, and the potential utility as well as questions raised by recent studies are discussed.

  20. Water Vapour Absorption in the Clear Atmosphere of an exo-Neptune

    CERN Document Server

    Fraine, Jonathan; Benneke, Björn; Knutson, Heather; Jordán, Andrés; Espinoza, Néstor; Madhusudhan, Nikku; Wilkins, Ashlee; Todorov, Kamen

    2014-01-01

    Transmission spectroscopy to date has detected atomic and molecular absorption in Jupiter-sized exoplanets, but intense efforts to measure molecular absorption in the atmospheres of smaller (Neptune-sized) planets during transits have revealed only featureless spectra. From this it was concluded that the majority of small, warm planets evolve to sustain high mean molecular weights, opaque clouds, or scattering hazes in their atmospheres, obscuring our ability to observe the composition of these atmospheres. Here we report observations of the transmission spectrum of HAT-P-11b (~4 Earth radii) from the optical to the infrared. We detected water vapour absorption at 1.4 micrometre wavelength. The amplitude of the water absorption (approximately 250 parts-per- million) indicates that the planetary atmosphere is predominantly clear down to ~1 mbar, and sufficiently hydrogen-rich to exhibit a large scale height. The spectrum is indicative of a planetary atmosphere with an upper limit of ~700 times the abundance of...