WorldWideScience

Sample records for replot pause 1

  1. Model of the pathway of −1 frameshifting: Long pausing

    Directory of Open Access Journals (Sweden)

    Ping Xie

    2016-03-01

    Full Text Available It has been characterized that the programmed ribosomal −1 frameshifting often occurs at the slippery sequence on the presence of a downstream mRNA pseudoknot. In some prokaryotic cases such as the dnaX gene of Escherichia coli, an additional stimulatory signal—an upstream, internal Shine–Dalgarno (SD sequence—is also necessary to stimulate the efficient −1 frameshifting. However, the molecular and physical mechanism of the −1 frameshifting is poorly understood. Here, we propose a model of the pathway of the −1 translational frameshifting during ribosome translation of the dnaX −1 frameshift mRNA. With the model, the single-molecule fluorescence data (Chen et al. (2014 [29] on the dynamics of the shunt either to long pausing or to normal translation, the tRNA transit and sampling dynamics in the long-paused rotated state, the EF-G sampling dynamics, the mean rotated-state lifetimes, etc., are explained quantitatively. Moreover, the model is also consistent with the experimental data (Yan et al. (2015 [30] on translocation excursions and broad branching of frameshifting pathways. In addition, we present some predicted results, which can be easily tested by future optical trapping experiments.

  2. Single-molecule analysis of inhibitory pausing states of V1-ATPase.

    Science.gov (United States)

    Uner, Naciye Esma; Nishikawa, Yoshihiro; Okuno, Daichi; Nakano, Masahiro; Yokoyama, Ken; Noji, Hiroyuki

    2012-08-17

    V(1)-ATPase, the hydrophilic V-ATPase domain, is a rotary motor fueled by ATP hydrolysis. Here, we found that Thermus thermophilus V(1)-ATPase shows two types of inhibitory pauses interrupting continuous rotation: a short pause (SP, 4.2 s) that occurred frequently during rotation, and a long inhibitory pause (LP, >30 min) that terminated all active rotations. Both pauses occurred at the same angle for ATP binding and hydrolysis. Kinetic analysis revealed that the time constants of inactivation into and activation from the SP were too short to represent biochemically predicted ADP inhibition, suggesting that SP is a newly identified inhibitory state of V(1)-ATPase. The time constant of inactivation into LP was 17 min, consistent with one of the two time constants governing the inactivation process observed in bulk ATPase assay. When forcibly rotated in the forward direction, V(1) in LP resumed active rotation. Solution ADP suppressed the probability of mechanical activation, suggesting that mechanical rotation enhanced inhibitory ADP release. These features were highly consistent with mechanical activation of ADP-inhibited F(1), suggesting that LP represents the ADP-inhibited state of V(1)-ATPase. Mechanical activation largely depended on the direction and angular displacement of forced rotation, implying that V(1)-ATPase rotation modulates the off rate of ADP.

  3. A Comparative Analysis of Pausing in Child and Adult Storytelling

    Science.gov (United States)

    Redford, Melissa A.

    2012-01-01

    The goals of the current study were (1) to assess differences in child and adult pausing, and (2) to determine whether characteristics of child and adult pausing can be explained by the same language variables. Spontaneous speech samples were obtained from ten 5-year-olds and their accompanying parent using a storytelling/retelling task. Analyses of pause frequency, duration, variation in durations, and pause location indicated that pause time decreased with retelling, but not with age group except when child and adult pausing was considered in its speech and language context. The results suggest that differences in child and adult pausing reflect differences in child and adult language, not in the cognitive resources allocated to language production PMID:23772097

  4. Visual memory during pauses between successive saccades.

    Science.gov (United States)

    Gersch, Timothy M; Kowler, Eileen; Schnitzer, Brian S; Dosher, Barbara A

    2008-12-22

    Selective attention is closely linked to eye movements. Prior to a saccade, attention shifts to the saccadic goal at the expense of surrounding locations. Such a constricted attentional field, while useful to ensure accurate saccades, constrains the spatial range of high-quality perceptual analysis. The present study showed that attention could be allocated to locations other than the saccadic goal without disrupting the ongoing pattern of saccades. Saccades were made sequentially along a color-cued path. Attention was assessed by a visual memory task presented during a random pause between successive saccades. Saccadic planning had several effects on memory: (1) fewer letters were remembered during intersaccadic pauses than during maintained fixation; (2) letters appearing on the saccadic path, including locations previously examined, could be remembered; off-path performance was near chance; (3) memory was better at the saccadic target than at all other locations, including the currently fixated location. These results show that the distribution of attention during intersaccadic pauses results from a combination of top-down enhancement at the saccadic target coupled with a more automatic allocation of attention to selected display locations. This suggests that the visual system has mechanisms to control the distribution of attention without interfering with ongoing saccadic programming.

  5. Effect of Sitting Pause Times on Balance After Supine to Standing Transfer in Dim Light.

    Science.gov (United States)

    Johnson, Eric G; Albalwi, Abdulaziz A; Al-Dabbak, Fuad M; Daher, Noha S

    2017-06-01

    The risk of falling for older adults increases in dimly lit environments. Longer sitting pause times, before getting out of bed and standing during the night, may improve postural stability. The purpose of this study was to measure the effect of sitting pause times on postural sway velocity immediately after a supine to standing transfer in a dimly lit room in older adult women. Eighteen healthy women aged 65 to 75 years who were able to independently perform supine to standing transfers participated in the study. On each of 2 consecutive days, participants assumed the supine position on a mat table and closed their eyes for 45 minutes. Then, participants were instructed to open their eyes and transfer from supine to sitting, with either 2- or 30-second pause in the sitting position followed by standing. The sitting pause time order was randomized. A significant difference was observed in postural sway velocity between the 2- and 30-second sitting pause times. The results revealed that there was less postural sway velocity after 30-second than 2-second sitting pause time (0.61 ± 0.19 vs 1.22 ± 0.68, P Falls related to bathroom usage at night are the most common reported falls among older adults. In the present study, the investigators studied the effect of sitting pause times on postural sway velocity after changing position from supine to standing in a dimly lit environment. The findings showed that the mean postural sway velocity was significantly less after 30-second sitting pause time compared with 2-second sitting pause time. Postural sway velocity decreased when participants performed a sitting pause of 30 seconds before standing in a dimly lit environment. These results suggest that longer sitting pause times may improve adaptability to dimly lit environments, contributing to improved postural stability and reduced risk of fall in older adult women when getting out of bed at night.

  6. Interword and intraword pause threshold in writing.

    Science.gov (United States)

    Chenu, Florence; Pellegrino, François; Jisa, Harriet; Fayol, Michel

    2014-01-01

    Writing words in real life involves setting objectives, imagining a recipient, translating ideas into linguistic forms, managing grapho-motor gestures, etc. Understanding writing requires observation of the processes as they occur in real time. Analysis of pauses is one of the preferred methods for accessing the dynamics of writing and is based on the idea that pauses are behavioral correlates of cognitive processes. However, there is a need to clarify what we are observing when studying pause phenomena, as we will argue in the first section. This taken into account, the study of pause phenomena can be considered following two approaches. A first approach, driven by temporality, would define a threshold and observe where pauses, e.g., scriptural inactivity occurs. A second approach, linguistically driven, would define structural units and look for scriptural inactivity at the boundaries of these units or within these units. Taking a temporally driven approach, we present two methods which aim at the automatic identification of scriptural inactivity which is most likely not attributable to grapho-motor management in texts written by children and adolescents using digitizing tablets in association with Eye and Pen (©) (Chesnet and Alamargot, 2005). The first method is purely statistical and is based on the idea that the distribution of pauses exhibits different Gaussian components each of them corresponding to a different type of pause. After having reviewed the limits of this statistical method, we present a second method based on writing dynamics which attempts to identify breaking points in the writing dynamics rather than relying only on pause duration. This second method needs to be refined to overcome the fact that calculation is impossible when there is insufficient data which is often the case when working with young scriptors.

  7. Fuel Loss and Jams due to Pausing Railroad Crossings

    OpenAIRE

    Tomoeda, Akiyasu; Nishinari, Katsuhiro; Harada, Yoshiaki

    2008-01-01

    In Japan, all cars must pause before crossing the railroad for avoiding the accidents. This rule was established by a law in 1960. In fact, however, railroad crossings come to the serious bottlenecks because of this pausing rule and this bottleneck causes heavy jams. In this study, by using cellular automaton model we have investigated the traffic flow at railroad crossings in two cases: with pausing and without pausing. Moreover, the lost time due to pausing at railroad crossings have been a...

  8. Pauses in Written Composition: On the Importance of Where Writers Pause

    Science.gov (United States)

    Medimorec, Srdan; Risko, Evan F.

    2017-01-01

    Much previous research has conceptualized pauses during writing as indicators of the engagement of higher-level cognitive processes. In the present study 101 university students composed narrative or argumentative essays, while their key logging was recorded. We investigated the relation between pauses within three time intervals (300-999,…

  9. The Surgical Teams' Perception of the Effects of a Routine Intraoperative Pause.

    Science.gov (United States)

    Erestam, Sofia; Angenete, Eva; Derwinger, Kristoffer

    2016-12-01

    A pause routine may reduce stress and errors during surgery. The aim of this study was to explore how the team, divided into the different professional groups, perceived the implementation of a pause routine and its possible impact on safety. A pause routine was introduced at a University hospital operating theatre in Sweden in 2013. Questionnaires were distributed about 1 year later to all members of the operating theatre team. The questions included different perspectives of possible effects of the pause routine. A majority were positive to scheduled pauses. The surgeons often felt refreshed and at times changed their view on both anatomy and their surgical strategy. They were also perceived by other team members as improved regarding communication. All groups felt that patient safety was promoted. There were differences by profession in perception of team communication. The pause routine was well perceived by the surgical team. A majority believed that scheduled and regular pauses contribute to improved patient safety and better team communication. There were also findings of differences in communication and experience of team coherence between personnel categories that could benefit from further acknowledgement and exploration.

  10. Pauses in theatrical interpretation: delimitation of prosodic constituents

    Directory of Open Access Journals (Sweden)

    Lourenço Chacon

    2014-07-01

    Full Text Available We intend to observe the function of a linguistic resource – the pause – in theatrical interpretation. Connected to the field of speech therapy, we search for theoretical support in the Linguistics field, mainly in prosodic phonology – specifically, we highlight intonational phrase and phonological utterance, prosodic constituents –, proposing a dialogue between these fields, regarding the work with actors. In speech therapy literature, the work with actors focuses, centrally, in organic issues involved in the vocal process, such as “misuse” or “voice abuse”. To a smaller extent, we find, in this literature, researches that emphasize issues regarding interpretation and expressive resources, besides a few emphasizing the importance of linguistic resources in interpretation. Differently, in linguistics literature, the pause is approached, to a larger extent, from the phonetic perspective, related to several language levels. In this research, we analyzed audio recordings of four actors from a same theatrical group, acting the theatrical text Brutas flores, focused on these aims: (1 detect the place where pauses happen in the interpretation of a single text by four actors; (2 survey physical characteristics of length of these pauses; (3 check to what extent the length of a pause is related to the place where it happens, regarding the prosodic limits of intonational phrases (I and phonological utterance (U. We could observe that, although the interpretation is characterized by the subjectivity of the actor, the interpretation is constructed based in the possibilities offered by the prosodic organization of the text itself, being more or less flexible.We were also able to confirm, by considering the length of VVs units containing pauses, the prosodic hierarchy proposed by Nespor & Vogel, once the length of these units in U's limits was significantly higher than the length in I's limits. Thus, our results reinforce the premise that a

  11. Pauses in spontaneous written communication: a keystroke logging study

    Directory of Open Access Journals (Sweden)

    Evgeny Chukharev-Hudilainen

    2014-06-01

    Full Text Available Spontaneous writing observed in chats, instant messengers, and social media has become established as productive modes of communication and discourse genres. However, they remain understudied from the perspective of writing process research. In this paper, we present an empirical study wherein keystrokes made by chat users in a game were recorded. The distributions of the inter-key intervals were analyzed and fitted with ex-Gaussian distribution equation, and an argument for psycholinguistic interpretation of the distribution parameters is presented. This analysis leads to establishing a threshold of 500 ms for the identification of pauses in spontaneous writing. Furthermore, we demonstrate that pauses longer than 1.2 s may correspond to higher-level linguistic processing beyond a single propositional expression (functional element of the discourse.

  12. Effect of timing and duration of a single chest compression pause on short-term survival following prolonged ventricular fibrillation.

    Science.gov (United States)

    Walcott, Gregory P; Melnick, Sharon B; Walker, Robert G; Banville, Isabelle; Chapman, Fred W; Killingsworth, Cheryl R; Ideker, Raymond E

    2009-04-01

    Pauses during chest compressions are thought to have a detrimental effect on resuscitation outcome. The Guidelines 2005 have recently eliminated the post-defibrillation pause. Previous animal studies have shown that multiple pauses of increasing duration decrease resuscitation success. We investigated the effect of varying the characteristics of a single pause near defibrillation on resuscitation outcome. Part A: 48 swine were anesthetized, fibrillated for 7min and randomized. Chest compressions were initiated for 90s followed by defibrillation and then resumption of chest compressions. Four groups were studied-G2000: 40s pause beginning 20s before, and ending 20s after defibrillation, A1: a 20s pause just before defibrillation, A2: a 20s pause ending 30s prior to defibrillation, and group A3: a 10s pause ending 30s prior to defibrillation. Part B: 12 swine (Group B) were studied with a protocol identical to Part A but with no pause in chest compressions. Primary endpoint was survival to 4h. The survival rate was significantly higher for groups A1, A2, A3, and B (5/12, 7/12, 5/12, and 5/12 survived) than for the G2000 group (0/12, p<0.05). Survival did not differ significantly among groups A1, A2, A3, and B. These results suggest that the Guidelines 2005 recommendation to omit the post-shock pulse check and immediately resume chest compressions may be an important resuscitation protocol change. However, these results also suggest that clinical maneuvers further altering a single pre-shock chest compression pause provide no additional benefit.

  13. Effect of timing and duration of a single chest compression pause on short-term survival following prolonged ventricular fibrillation☆

    Science.gov (United States)

    Walcott, Gregory P.; Melnick, Sharon B.; Walker, Robert G.; Banville, Isabelle; Chapman, Fred W.; Killingsworth, Cheryl R.; Ideker, Raymond E.

    2014-01-01

    Background Pauses during chest compressions are thought to have a detrimental effect on resuscitation outcome. The Guidelines 2005 have recently eliminated the post-defibrillation pause. Previous animal studies have shown that multiple pauses of increasing duration decrease resuscitation success. We investigated the effect of varying the characteristics of a single pause near defibrillation on resuscitation outcome. Methods Part A: 48 swine were anesthetized, fibrillated for 7 min and randomized. Chest compressions were initiated for 90 s followed by defibrillation and then resumption of chest compressions. Four groups were studied—G2000: 40 s pause beginning 20 s before, and ending 20 s after defibrillation, A1: a 20 s pause just before defibrillation, A2: a 20 s pause ending 30 s prior to defibrillation, and group A3: a 10 s pause ending 30 s prior to defibrillation. Part B: 12 swine (Group B) were studied with a protocol identical to Part A but with no pause in chest compressions. Primary endpoint was survival to 4 h. Results The survival rate was significantly higher for groups A1, A2, A3, and B (5/12, 7/12, 5/12, and 5/12 survived) than for the G2000 group (0/12, p < 0.05). Survival did not differ significantly among groups A1, A2, A3, and B. Conclusions These results suggest that the Guidelines 2005 recommendation to omit the post-shock pulse check and immediately resume chest compressions may be an important resuscitation protocol change. However, these results also suggest that clinical maneuvers further altering a single pre-shock chest compression pause provide no additional benefit. PMID:19185411

  14. CDK9-dependent RNA polymerase II pausing controls transcription initiation.

    Science.gov (United States)

    Gressel, Saskia; Schwalb, Björn; Decker, Tim Michael; Qin, Weihua; Leonhardt, Heinrich; Eick, Dirk; Cramer, Patrick

    2017-10-10

    Gene transcription can be activated by decreasing the duration of RNA polymerase II pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we use a 'multi-omics' approach to demonstrate that the duration of polymerase pausing generally limits the productive frequency of transcription initiation in human cells ('pause-initiation limit'). We further engineer a human cell line to allow for specific and rapid inhibition of the P-TEFb kinase CDK9, which is implicated in polymerase pause release. CDK9 activity decreases the pause duration but also increases the productive initiation frequency. This shows that CDK9 stimulates release of paused polymerase and activates transcription by increasing the number of transcribing polymerases and thus the amount of mRNA synthesized per time. CDK9 activity is also associated with long-range chromatin interactions, suggesting that enhancers can influence the pause-initiation limit to regulate transcription.

  15. ON THE PAUSED WARMING CONTROVERSY BASED ON IPCC AR5 AND BEYOND

    Directory of Open Access Journals (Sweden)

    MIKA J.

    2014-03-01

    Full Text Available The paused warming since ca. 2002 (maybe, 1998 is not satisfactorily reflected by the IPCC WGI (2013 Report. The aim of the present study is to collect, present and discuss the key arguments of the issue, selected strictly from this valuable Report. Our study tackles three aspects: (i Symptoms of pausing, including atmospheric changes, near-surface oceans, cryosphere and geographical differences. (ii Possible reasons of the paused warming, including external forcing factors, playing rather minor role, and the enhanced ocean heat uptake. Though missing warming is 0.2 K/decade compared to the model expectations, the whole climate system integrates continuously increasing amount of heat, 95 % of which is locked in the oceans. (iii Consequences of the pausing for the three main branches of the IPCC activity. For climate science, correct simulation of the enhanced heat uptake is a challenge. Since characteristic time scale of most adaptation measures is 1-2 decades, or shorter, near-term projections may not drive adaptation until climate models become able meet this challenge. On the other hand, pausing warming does not question the need for mitigation, since it is physically unlikely, that oceans can uptake endless amount of heat. Vertical temperature gradients of the upper ocean layers already show stagnation.

  16. Using Habit Reversal to Decrease Filled Pauses in Public Speaking

    Science.gov (United States)

    Mancuso, Carolyn; Miltenberger, Raymond G.

    2016-01-01

    This study evaluated the effectiveness of simplified habit reversal in reducing filled pauses that occur during public speaking. Filled pauses consist of "uh," "um," or "er"; clicking sounds; and misuse of the word "like." After baseline, participants received habit reversal training that consisted of…

  17. Phonetic Pause Unites Phonology and Semantics against Morphology and Syntax

    Science.gov (United States)

    Sakarna, Ahmad Khalaf; Mobaideen, Adnan

    2012-01-01

    The present study investigates the phonological effect triggered by the different types of phonetic pause used in Quran on morphology, syntax, and semantics. It argues that Quranic pause provides interesting evidence about the close relation between phonology and semantics, from one side, and semantics, morphology, and syntax, from the other…

  18. Global distribution of pauses observed with satellite measurements

    Indian Academy of Sciences (India)

    Here we study the commonality and differences observed in the variability of all the pauses. We also examined how good other datasets will represent these features among (and in between) different satellite measurements, re-analysis, and model data. Hemispheric differences observed in all the pauses are also reported.

  19. Influence of pauses in irradiation on radiotherapy effect

    International Nuclear Information System (INIS)

    Skladowski, K.; Tarnawski, R.; Swierniak, A.

    1999-01-01

    The main goal of the study was demonstration, that pauses in radiotherapy of head and neck neoplasms dramatically influence on therapy results estimated as tumor control probability (TCP). The reason of this phenomenon is duplication of tumor cell proliferation during pauses in radiotherapy. This hypothesis is demonstrated on the analysis of statistical models, which parameters were estimated from the data of 1350 patients treated with radiotherapy in Center of Oncology in 1980-1989

  20. Neural correlates of the processing of unfilled and filled pauses

    OpenAIRE

    Eklund, Robert; Fransson, Peter; Ingvar, Martin

    2015-01-01

    Spontaneously produced Unfilled Pauses (UPs) andFilled Pauses (FPs) were played to subjects in an fMRI experiment. While both stimuli resulted in increased activity in the Primary Auditory Cortex, FPs, unlike UPs, also elicited modulation in the Supplementary Motor Area, Brodmann Area 6. This observation provides neurocognitive confirmation of the oft-reported difference between FPs and other kinds of speech disfluency and also could provide a partial explanation for the previously reported b...

  1. Plastid ribosome pausing is induced by multiple features and is linked to protein complex assembly

    DEFF Research Database (Denmark)

    Gawroński, Piotr; Jensen, Poul Erik; Karpinski, Stanislaw

    2018-01-01

    Many mRNAs contain pause sites that briefly interrupt the progress of translation. Specific features that induce ribosome pausing have been described; however, their individual contributions to pause-site formation, and the overall biological significance of ribosome pausing, remain largely uncle...

  2. Pauses by Student and Professional Translators in Translation Process

    Directory of Open Access Journals (Sweden)

    Rusdi Noor Rosa

    2018-01-01

    Full Text Available Translation as a process of meaning making activity requires a cognitive process one of which is realized in a pause, a temporary stop or a break indicating doing other than typing activities in a certain period of translation process. Scholars agree that pauses are an indicator of cognitive process without which there will never be any translation practices. Despite such agreement, pauses are debatable as well, either in terms of their length or in terms of the activities managed by a translator while taking pauses. This study, in particular, aims at finding out how student translators and professional translators managed the pauses in a translation process. This was a descriptive research taking two student translators and two professional translators as the participants who were asked to translate a text from English into bahasa Indonesia. The source text (ST was a historical recount text entitled ‘Early History of Yellowstone National Park’ downloaded from http://www.nezperce.com/yelpark9.html composed of 230-word long from English into bahasa Indonesia. The data were collected using Translog protocols, think aloud protocols (TAPs and screen recording. Based on the data analysis, it was found that student translators took the longest pauses in the drafting phase spent to solve the problems related to finding out the right equivalent for the ST words or terms and to solve the difficulties encountered in encoding their ST understanding in the TL; meanwhile, professional translators took the longest pauses in the pos-drafting phase spent to ensure whether their TT had been natural and whether their TT had corresponded to the prevailing grammatical rules of the TL.

  3. Profiles and Pauses: Two Practical Activities for the Writing Class

    Directory of Open Access Journals (Sweden)

    Ernest Hall

    1998-01-01

    Full Text Available Abstract : This article describes two classroom activities, "Profiling" and "Pause Analysis", that can be successfully used in ESL writing classes. "Profiling" addresses such problems as poor development of ideas, simplistic ideas, and lack of coherence in written texts. "Pause Analysis" focusses on the thinking processes that students engage in while drafting text, processes such as searching for ideas, evaluat­ing ideas, and postponing ideas. Both activities enable the instructor to assume the role of intervener in the students' writing processes, rather than evaluator of the text produced. In drawing The attention of the student write to both product and process, "Profiling" and "Pause Analysis" help them develop an awareness of the relation-ship between ideas in English expository text and the thinking pro­cesses that writers engage in while drafting such text.

  4. Global distribution of pauses observed with satellite measurements

    Indian Academy of Sciences (India)

    We present global distribution of altitudes and temperatures of these pauses observed with long-term space borne high- ... metries between northern and southern hemispheres continue up to the mesopause. We analyze ..... the mean temperature increases from the equa- .... monsoon circulation causes zonal asymmetry in.

  5. Management of paroxysmal ectopic atrial tachycardia with long sinus pauses in a teenager

    OpenAIRE

    Seshadri Balaji

    2015-01-01

    Sinus pauses in the setting of supraventricular tachycardia is rare in children. We describe an asymptomatic teen with irregular heart rate detected during an incidental exam who was found to have short runs of a slow ectopic atrial tachycardia on electrocardiogram and prolonged sinus pauses on routine ambulatory ECG. Successful catheter ablation of the ectopic atrial tachycardia led to resolution of the sinus pauses.

  6. Responsible gambling tools: pop-up messages and pauses on video lottery terminals.

    Science.gov (United States)

    Cloutier, Martin; Ladouceur, Robert; Sévigny, Serge

    2006-09-01

    The authors examined the effect of messages and pauses, presented on video lottery terminal screens, on erroneous beliefs and persistence to play. At posttest, the strength of erroneous beliefs was lower for participants who received messages conveying information about randomness in gambling as compared to those who received pauses. Pauses also diminished the strength of erroneous beliefs, and there was no difference between the effects of pauses and messages on the number of games played. The authors discuss these results in terms of the use of messages and pauses on video lottery terminals as a strategy for promoting responsible gambling.

  7. Barack Obama’s pauses and gestures in humorous speeches

    DEFF Research Database (Denmark)

    Navarretta, Costanza

    2017-01-01

    The main aim of this paper is to investigate speech pauses and gestures as means to engage the audience and present the humorous message in an effective way. The data consist of two speeches by the USA president Barack Obama at the 2011 and 2016 Annual White House Correspondents’ Association Dinner...... produced significantly more hand gestures in 2016 than in 2011. An analysis of the hand gestures produced by Barack Obama in two political speeches held at the United Nations in 2011 and 2016 confirms that the president produced significantly less communicative co-speech hand gestures during his speeches...... and they emphasise the speech segment which they follow or precede. We also found a highly significant correlation between Obama’s speech pauses and audience response. Obama produces numerous head movements, facial expressions and hand gestures and their functions are related to both discourse content and structure...

  8. Backtracking dynamics of RNA polymerase: pausing and error correction

    Science.gov (United States)

    Sahoo, Mamata; Klumpp, Stefan

    2013-09-01

    Transcription by RNA polymerases is frequently interrupted by pauses. One mechanism of such pauses is backtracking, where the RNA polymerase translocates backward with respect to both the DNA template and the RNA transcript, without shortening the transcript. Backtracked RNA polymerases move in a diffusive fashion and can return to active transcription either by diffusive return to the position where backtracking was initiated or by cleaving the transcript. The latter process also provides a mechanism for proofreading. Here we present some exact results for a kinetic model of backtracking and analyse its impact on the speed and the accuracy of transcription. We show that proofreading through backtracking is different from the classical (Hopfield-Ninio) scheme of kinetic proofreading. Our analysis also suggests that, in addition to contributing to the accuracy of transcription, backtracking may have a second effect: it attenuates the slow down of transcription that arises as a side effect of discriminating between correct and incorrect nucleotides based on the stepping rates.

  9. Comparison of pause predictions of two sequence-dependent transcription models

    International Nuclear Information System (INIS)

    Bai, Lu; Wang, Michelle D

    2010-01-01

    Two recent theoretical models, Bai et al (2004, 2007) and Tadigotla et al (2006), formulated thermodynamic explanations of sequence-dependent transcription pausing by RNA polymerase (RNAP). The two models differ in some basic assumptions and therefore make different yet overlapping predictions for pause locations, and different predictions on pause kinetics and mechanisms. Here we present a comprehensive comparison of the two models. We show that while they have comparable predictive power of pause locations at low NTP concentrations, the Bai et al model is more accurate than Tadigotla et al at higher NTP concentrations. The pausing kinetics predicted by Bai et al is also consistent with time-course transcription reactions, while Tadigotla et al is unsuited for this type of kinetic prediction. More importantly, the two models in general predict different pausing mechanisms even for the same pausing sites, and the Bai et al model provides an explanation more consistent with recent single molecule observations

  10. La pause dans la conversation en arabe marocain

    Directory of Open Access Journals (Sweden)

    Mounia TOUIAQ

    2011-11-01

    Full Text Available The work presented here focuses on how the structuring of spontaneous conversation is related to prosody. How the prosodic parameters, including the break, they fit into a logical demarcation, establishment and organization of parts of speech? To what extent are they relevant to the level of dis-course, intersubjective and interactional? Description of these data allowed us to understand different ways of structuring Moroccan spooked Arabic, prosodic point of view, but also in terms of thematic and interactional, without ever losing sight of the conversational speech is the location of enunciation issues to establish meaning. In the situation of a real conversation, the silence is an opportunity for a transfer of initiative or by speaking one or other of these contacts. On the other hand, the speaker who wishes to keep talking should avoid the use of the silent pause and use in preference to the filled pause. We hypothesize that one role of the silent pause is precisely to manage this aspect of the intersubjective and interactional space and to indicate whether a segment aims to allow the speaker to keep talking or given it to the caller.

  11. Cerebellar Nuclear Neurons Use Time and Rate Coding to Transmit Purkinje Neuron Pauses.

    Science.gov (United States)

    Sudhakar, Shyam Kumar; Torben-Nielsen, Benjamin; De Schutter, Erik

    2015-12-01

    Neurons of the cerebellar nuclei convey the final output of the cerebellum to their targets in various parts of the brain. Within the cerebellum their direct upstream connections originate from inhibitory Purkinje neurons. Purkinje neurons have a complex firing pattern of regular spikes interrupted by intermittent pauses of variable length. How can the cerebellar nucleus process this complex input pattern? In this modeling study, we investigate different forms of Purkinje neuron simple spike pause synchrony and its influence on candidate coding strategies in the cerebellar nuclei. That is, we investigate how different alignments of synchronous pauses in synthetic Purkinje neuron spike trains affect either time-locking or rate-changes in the downstream nuclei. We find that Purkinje neuron synchrony is mainly represented by changes in the firing rate of cerebellar nuclei neurons. Pause beginning synchronization produced a unique effect on nuclei neuron firing, while the effect of pause ending and pause overlapping synchronization could not be distinguished from each other. Pause beginning synchronization produced better time-locking of nuclear neurons for short length pauses. We also characterize the effect of pause length and spike jitter on the nuclear neuron firing. Additionally, we find that the rate of rebound responses in nuclear neurons after a synchronous pause is controlled by the firing rate of Purkinje neurons preceding it.

  12. Cerebellar Nuclear Neurons Use Time and Rate Coding to Transmit Purkinje Neuron Pauses

    Science.gov (United States)

    Sudhakar, Shyam Kumar; Torben-Nielsen, Benjamin; De Schutter, Erik

    2015-01-01

    Neurons of the cerebellar nuclei convey the final output of the cerebellum to their targets in various parts of the brain. Within the cerebellum their direct upstream connections originate from inhibitory Purkinje neurons. Purkinje neurons have a complex firing pattern of regular spikes interrupted by intermittent pauses of variable length. How can the cerebellar nucleus process this complex input pattern? In this modeling study, we investigate different forms of Purkinje neuron simple spike pause synchrony and its influence on candidate coding strategies in the cerebellar nuclei. That is, we investigate how different alignments of synchronous pauses in synthetic Purkinje neuron spike trains affect either time-locking or rate-changes in the downstream nuclei. We find that Purkinje neuron synchrony is mainly represented by changes in the firing rate of cerebellar nuclei neurons. Pause beginning synchronization produced a unique effect on nuclei neuron firing, while the effect of pause ending and pause overlapping synchronization could not be distinguished from each other. Pause beginning synchronization produced better time-locking of nuclear neurons for short length pauses. We also characterize the effect of pause length and spike jitter on the nuclear neuron firing. Additionally, we find that the rate of rebound responses in nuclear neurons after a synchronous pause is controlled by the firing rate of Purkinje neurons preceding it. PMID:26630202

  13. Pauses in Striatal Cholinergic Interneurons: What is Revealed by Their Common Themes and Variations?

    Directory of Open Access Journals (Sweden)

    Yan-Feng Zhang

    2017-10-01

    Full Text Available Striatal cholinergic interneurons, the so-called tonically active neurons (TANs, pause their firing in response to sensory cues and rewards during classical conditioning and instrumental tasks. The respective pause responses observed can demonstrate many commonalities, such as constant latency and duration, synchronous occurrence in a population of cells, and coincidence with phasic activities of midbrain dopamine neurons (DANs that signal reward predictions and errors. Pauses can however also show divergent properties. Pause latencies and durations can differ in a given TAN between appetitive vs. aversive outcomes in classical conditioning, initial excitation can be present or absent, and a second pause can variably follow a rebound. Despite more than 20 years of study, the functions of these pause responses are still elusive. Our understanding of pause function is hindered by an incomplete understanding of how pauses are generated. In this mini-review article, we compare pause types, as well as current key hypotheses for inputs underlying pauses that include dopamine-induced inhibition through D2-receptors, a GABA input from ventral tegmental area, and a prolonged afterhyperpolarization induced by excitatory input from the cortex or from the thalamus. We review how each of these mechanisms alone explains some but not all aspects of pause responses. These mechanisms might need to operate in specific but variable sets of sequences to generate a full range of pause responses. Alternatively, these mechanisms might operate in conjunction with an underlying control mechanism within cholinergic interneurons which could potentially provide a framework to generate the common themes and variations seen amongst pause responses.

  14. Can exposure variation be promoted in the shoulder girdle muscles by modifying work pace and inserting pauses during simulated assembly work?

    Science.gov (United States)

    Januario, Leticia Bergamin; Madeleine, Pascal; Cid, Marina Machado; Samani, Afshin; Oliveira, Ana Beatriz

    2018-01-01

    This study investigated the acute effects of changing the work pace and implementing two pause types during an assembly task. Eighteen healthy women performed a simulated task in four different conditions: 1) slow or 2) fast work pace with 3) passive or 4) active pauses every two minutes. The root mean square (RMS) and exposure variation analysis (EVA) from the trapezius and serratus anterior muscles, as well as the rate of perceived exertion (RPE) from the neck-shoulder region, were observed. Decreased RMS and RPE as well as more variable muscle activity (EVA) were observed in the slow work pace compared with the fast one. The pause types had a limited effect, but active pauses resulted in increased RMS of the clavicular trapezius. The findings revealed the importance of work pace in the reduction of perceived exertion and promotion of variation in muscle activation during assembly tasks. However, the pause types had no important effect on the evaluated outcomes. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Effect of rest-pause vs. traditional bench press training on muscle strength, electromyography, and lifting volume in randomized trial protocols.

    Science.gov (United States)

    Korak, J Adam; Paquette, Max R; Brooks, Justin; Fuller, Dana K; Coons, John M

    2017-09-01

    Rest-pause (4-s unloaded rest between repetitions) training effects on one repetition maximum (1 RM), lifting volume, and neural activation via electromyography (EMG) are currently vague in the literature and can benefit strength and conditioning professionals for resistance training programme design. Therefore, this study compared 1 RM, neural activation via (EMG), and volume differences between rest-pause vs. traditional resistance training. Trained males (N = 20) were randomly assigned to either a rest-pause or a traditional training group. Pre- and post-1 RM testing was recorded. Training sessions were completed twice a week for 4 weeks and consisted of four sets of bench press to volitional fatigue at 80% of pre-test 1 RM with a 2-min rest between sets. Total volume completed was recorded on each training day. Neural activation of the pectoralis major was measured on the first and last training days. A two-way repeated-measures ANOVA indicated both groups significantly increased their 1 RMs following the 4-week training protocol (p  .05). An independent samples t test indicated that total volume lifted was significantly higher for the rest-pause group (56,778 vs. 38,315 lbs; p < .05) throughout the protocol and independently during weeks 2, 3, and 4. While strength and neural activation changes did not differ between groups, both increased 1 RMs and the rest-pause group achieved greater increases in volume than the traditional group. If volume is the focus of training, the rest-pause method should be utilized.

  16. Backtracking dynamics of RNA polymerase: pausing and error correction

    International Nuclear Information System (INIS)

    Sahoo, Mamata; Klumpp, Stefan

    2013-01-01

    Transcription by RNA polymerases is frequently interrupted by pauses. One mechanism of such pauses is backtracking, where the RNA polymerase translocates backward with respect to both the DNA template and the RNA transcript, without shortening the transcript. Backtracked RNA polymerases move in a diffusive fashion and can return to active transcription either by diffusive return to the position where backtracking was initiated or by cleaving the transcript. The latter process also provides a mechanism for proofreading. Here we present some exact results for a kinetic model of backtracking and analyse its impact on the speed and the accuracy of transcription. We show that proofreading through backtracking is different from the classical (Hopfield–Ninio) scheme of kinetic proofreading. Our analysis also suggests that, in addition to contributing to the accuracy of transcription, backtracking may have a second effect: it attenuates the slow down of transcription that arises as a side effect of discriminating between correct and incorrect nucleotides based on the stepping rates. (paper)

  17. Absence of Non-histone Protein Complexes at Natural Chromosomal Pause Sites Results in Reduced Replication Pausing in Aging Yeast Cells

    Directory of Open Access Journals (Sweden)

    Marleny Cabral

    2016-11-01

    Full Text Available There is substantial evidence that genomic instability increases during aging. Replication pausing (and stalling at difficult-to-replicate chromosomal sites may induce genomic instability. Interestingly, in aging yeast cells, we observed reduced replication pausing at various natural replication pause sites (RPSs in ribosomal DNA (rDNA and non-rDNA locations (e.g., silent replication origins and tRNA genes. The reduced pausing occurs independent of the DNA helicase Rrm3p, which facilitates replication past these non-histone protein-complex-bound RPSs, and is independent of the deacetylase Sir2p. Conditions of caloric restriction (CR, which extend life span, also cause reduced replication pausing at the 5S rDNA and at tRNA genes. In aged and CR cells, the RPSs are less occupied by their specific non-histone protein complexes (e.g., the preinitiation complex TFIIIC, likely because members of these complexes have primarily cytosolic localization. These conditions may lead to reduced replication pausing and may lower replication stress at these sites during aging.

  18. On the biased motion of a brownian particle for the pausing time behavior of the CTRW

    International Nuclear Information System (INIS)

    Kim, K.S.

    1982-01-01

    The purpose of this paper is to discuss the biased Brownian motion with the absorbing barrier for the pausing time behavior of the CTRW (continuous-time random walk method), regarding a Brownian particle as a walker. For two pausing time density functions, the respective values for the transport averaged velocity and the dispersion are calculated as the time t becomes large. (KAERI)

  19. Integration of active pauses and pattern of muscular activity during computer work.

    Science.gov (United States)

    St-Onge, Nancy; Samani, Afshin; Madeleine, Pascal

    2017-09-01

    Submaximal isometric muscle contractions have been reported to increase variability of muscle activation during computer work; however, other types of active contractions may be more beneficial. Our objective was to determine which type of active pause vs. rest is more efficient in changing muscle activity pattern during a computer task. Asymptomatic regular computer users performed a standardised 20-min computer task four times, integrating a different type of pause: sub-maximal isometric contraction, dynamic contraction, postural exercise and rest. Surface electromyographic (SEMG) activity was recorded bilaterally from five neck/shoulder muscles. Root-mean-square decreased with isometric pauses in the cervical paraspinals, upper trapezius and middle trapezius, whereas it increased with rest. Variability in the pattern of muscular activity was not affected by any type of pause. Overall, no detrimental effects on the level of SEMG during active pauses were found suggesting that they could be implemented without a cost on activation level or variability. Practitioner Summary: We aimed to determine which type of active pause vs. rest is best in changing muscle activity pattern during a computer task. Asymptomatic computer users performed a standardised computer task integrating different types of pauses. Muscle activation decreased with isometric pauses in neck/shoulder muscles, suggesting their implementation during computer work.

  20. Quiet is the new loud: pausing and focus in child and adult Dutch.

    Science.gov (United States)

    Romøren, Anna Sara H; Chen, Aoju

    2015-03-01

    In a number of languages, prosody is used to highlight new information (or focus). In Dutch, focus is marked by accentuation, whereby focal constituents are accented and post-focal constituents are de-accented. Even if pausing is not traditionally seen as a cue to focus in Dutch, several previous studies have pointed to a possible relationship between pausing and information structure. Considering that Dutch-speaking 4 to 5 year olds are not yet completely proficient in using accentuation for focus and that children generally pause more than adults, we asked whether pausing might be an available parameter for children to manipulate for focus. Sentences with varying focus structure were elicited from 10 Dutch-speaking 4 to 5 year olds and 9 Dutch-speaking adults by means of a picture-matching game. Comparing pause durations before focal and non-focal targets showed pre-target pauses to be significantly longer when the targets were focal than when they were not. Notably, the use of pausing was more robust in the children than in the adults, suggesting that children exploit pausing to mark focus more generally than adults do, at a stage where their mastery of the canonical cues to focus is still developing.

  1. A rule-based backchannel prediction model using pitch and pause information

    NARCIS (Netherlands)

    Truong, Khiet Phuong; Poppe, Ronald Walter; Heylen, Dirk K.J.

    We manually designed rules for a backchannel (BC) prediction model based on pitch and pause information. In short, the model predicts a BC when there is a pause of a certain length that is preceded by a falling or rising pitch. This model was validated against the Dutch IFADV Corpus in a

  2. Active pauses induce more variable electromyographic pattern of the trapezius muscle activity during computer work

    DEFF Research Database (Denmark)

    Samani, Afshin; Holtermann, Andreas; Søgaard, Karen

    2009-01-01

    , with passive (relax) and active (30% maximum voluntary contraction of shoulder elevation) pauses given every 2 min at two different work paces (low/high). Bipolar SEMG from four parts of the trapezius muscle was recorded. The relative rest time was higher for the lower parts compared with the upper......The aim of this laboratory study was to evaluate effects of active and passive pauses and investigate the distribution of the trapezius surface electromyographic (SEMG) activity during computer mouse work. Twelve healthy male subjects performed four sessions of computer work for 10 min in one day...... of the trapezius (pwork with active pause compared with passive one (p

  3. Experimental pain leads to reorganisation of trapezius electromyography during computer work with active and passive pauses

    DEFF Research Database (Denmark)

    Samani, Afshin; Holtermann, Andreas; Søgaard, Karen

    2009-01-01

    The aim of this laboratory study was to investigate acute effects of experimental muscle pain on spatial electromyographic (EMG) activity of the trapezius muscle during computer work with active and passive pauses. Twelve healthy male subjects performed four sessions of computer work for 2 min...... in one day, with passive (relax) and active (30% maximum voluntary contraction of shoulder elevation) pauses given every 40 s without and with presence of experimental pain. Surface EMG signals were recorded from four parts of the trapezius. The centroid of exposure variation analysis along the time axis...... was lower during computer work with active pauses when compared with passive one in all muscle parts (P

  4. Effects of eccentric exercise on trapezius electromyography during computer work with active and passive pauses

    DEFF Research Database (Denmark)

    Samani, Afshin; Holtermann, Andreas; Søgaard, Karen

    2009-01-01

    ) and active (30% maximum voluntary contraction of shoulder elevation) pauses given every 40s over 2 days, before, immediately and 24h after eccentric exercise. Surface EMG signals were recorded from four parts of the trapezius during computer work. FINDINGS: EMG amplitude during computer work decreased......BACKGROUND: The aim of this laboratory study was to investigate the effects of eccentric exercises on the trapezius muscle spatial electromyographic (EMG) activity during computer work with active and passive pauses. METHODS: Twelve healthy male subjects performed computer work with passive (relax...... immediately after exercise (Pwork with active pauses compared with passive ones (P

  5. Effective Use of Pause Procedure to Enhance Student Engagement and Learning

    OpenAIRE

    Bachhel, Rachna; Thaman, Richa Ghay

    2014-01-01

    Introduction: Active learning strategies have been documented to enhance learning. We created an active learning environment in neuromuscular physiology lectures for first year medical students by using ‘Pause Procedure’.

  6. Effects of a metronome on the filled pauses of fluent speakers.

    Science.gov (United States)

    Christenfeld, N

    1996-12-01

    Filled pauses (the "ums" and "uhs" that litter spontaneous speech) seem to be a product of the speaker paying deliberate attention to the normally automatic act of talking. This is the same sort of explanation that has been offered for stuttering. In this paper we explore whether a manipulation that has long been known to decrease stuttering, synchronizing speech to the beats of a metronome, will then also decrease filled pauses. Two experiments indicate that a metronome has a dramatic effect on the production of filled pauses. This effect is not due to any simplification or slowing of the speech and supports the view that a metronome causes speakers to attend more to how they are talking and less to what they are saying. It also lends support to the connection between stutters and filled pauses.

  7. Theoretical evaluation of transcriptional pausing effect on the attenuation in trp leader sequence

    OpenAIRE

    Suzuki, H.; Kunisawa, T.; Otsuka, J.

    1986-01-01

    The effect of transcriptional pausing on attenuation is investigated theoretically on the basis of the attenuation control mechanism presented by Oxender et al. (Oxender, D. L., G. Zurawski, and C. Yanofsky, 1979, Proc. Natl. Acad. Sci. USA. 76:5524-5528). An extended stochastic model including the RNA polymerase pausing in the leader region is developed to calculate the probability of relative position between the RNA polymerase transcribing the trp leader sequence and the ribosome translati...

  8. Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells

    Directory of Open Access Journals (Sweden)

    Giorgio Grasselli

    2016-03-01

    Full Text Available The plasticity of intrinsic excitability has been described in several types of neurons, but the significance of non-synaptic mechanisms in brain plasticity and learning remains elusive. Cerebellar Purkinje cells are inhibitory neurons that spontaneously fire action potentials at high frequencies and regulate activity in their target cells in the cerebellar nuclei by generating a characteristic spike burst-pause sequence upon synaptic activation. Using patch-clamp recordings from mouse Purkinje cells, we find that depolarization-triggered intrinsic plasticity enhances spike firing and shortens the duration of spike pauses. Pause plasticity is absent from mice lacking SK2-type potassium channels (SK2−/− mice and in occlusion experiments using the SK channel blocker apamin, while apamin wash-in mimics pause reduction. Our findings demonstrate that spike pauses can be regulated through an activity-dependent, exclusively non-synaptic, SK2 channel-dependent mechanism and suggest that pause plasticity—by altering the Purkinje cell output—may be crucial to cerebellar information storage and learning.

  9. How long is too long? How pause features after requests affect the perceived willingness of affirmative answers

    DEFF Research Database (Denmark)

    Kohtz, Lea Susan; Niebuhr, Oliver

    2017-01-01

    willingness was found to decrease with increasing pause duration, particularly above a "tolerance threshold" of 600 ms. Refining and qualifying this replicated result, the perception experiment showed additional effects of speaking-rate context and pause quality (silence vs. breathing vs. café noise......) on perceived willingness judgments. The overall results picture is discussed with respect to the origin of the "tolerance threshold", the status of breathing in speech, and the function of pauses in communication....

  10. The history of research on the filled pause as evidence of the written language bias in linguistics (Linell, 1982).

    Science.gov (United States)

    O'Connell, Daniel C; Kowal, Sabine

    2004-11-01

    Erard's (2004) publication in the New York Times of a journalistic history of the filled pause serves as the occasion for this critical review of the past half-century of research on the filled pause. Historically, the various phonetic realizations or instantiations of the filled pause have been presented with an odd recurrent admixture of the interjection ah. In addition, the filled pause has been consistently associated with both hesitation and disfluency. The present authors hold that such a mandatory association of the filled pause with disfluency is the product of The written language bias in linguistics [Linell, 1982] and disregards much cogent evidence to the contrary. The implicit prescriptivism of well formedness--a demand derived from literacy--must be rejected; literate well formedness is not a necessary or even typical property of spontaneous spoken discourse; its structures and functions--including those of the filled pause--are very different from those of written language The recent work of Clark and Fox Tree (2002) holds promise for moving the status of the filled pause not only toward that of a conventional word, but also toward its status as an interjection. This latter development is also being fostered by lexicographers. Nonetheless, in view of ongoing research regarding the disparate privileges of occurrence and functions of filled pauses in comparison with interjections, the present authors are reluctant to categorize the filled pause as an interjection.

  11. An Investigation of the Effects of Different Types of Activities during Pauses in a Segmented Instructional Animation

    Science.gov (United States)

    Cheon, Jongpil; Chung, Sungwon; Crooks, Steven M.; Song, Jaeki; Kim, Jeakyeong

    2014-01-01

    Since the complex and transient information in instructional animations requires more cognitive resources, the segmenting principle has been proposed to reduce cognitive overload by providing smaller chunks with pauses between segments. This study examined the effects of different types of activities during pauses in a segmented animation. Four…

  12. Discrete sequence production with and without a pause: the role of cortex, basal ganglia and cerebellum

    NARCIS (Netherlands)

    Jouen, A.-L.; Verwey, Willem B.; van der Helden, J.; Scheiber, C.; Neveu, R.; Dominey, P.F.; Ventre-Dominey, J.

    2013-01-01

    Our sensorimotor experience unfolds in sequences over time. We hypothesize that the processing of movement sequences with and without a temporal pause will recruit distinct but cooperating neural processes, including cortico-striatal and cortico-cerebellar networks. We thus, compare neural activity

  13. Quiet is the New Loud : Pausing and Focus in Child and Adult Dutch

    NARCIS (Netherlands)

    Romøren, Anna Sara H; Chen, Aoju

    2015-01-01

    In a number of languages, prosody is used to highlight new information (or focus). In Dutch, focus is marked by accentuation, whereby focal constituents are accented and post-focal constituents are de-accented. Even if pausing is not traditionally seen as a cue to focus in Dutch, several previous

  14. Cues-Pause-Point Language Training: Teaching Echolalics Functional Use of Their Verbal Labeling Repertoires.

    Science.gov (United States)

    McMorrow, Martin J.; And Others

    1987-01-01

    A cues-pause-point procedure was used to train two severely retarded females to remain quiet before, during, and briefly after the presentation of questions and then to verbalize on the basis of environmental cues whose labels represented the correct responses. Echolalia was rapidly replaced by correct responding on the trained stimuli. (Author/JW)

  15. Modified pause schemes and working days for more volume flexibility in manufactering

    NARCIS (Netherlands)

    Rhijn, G.; Looze, M. de; Bosch, T.

    2005-01-01

    The effects of two measures to increase the volume flexibility, namely the introduction of an alternating pause scheme and the elongation of the working day, were evaluated in two manufacturing companies. Both measures led to an increase in volume output of about 16% at relatively low costs. The

  16. Automated detection of unfilled pauses in speech of healthy and brain-damaged individuals

    NARCIS (Netherlands)

    Ossewaarde, Roelant; Jonkers, Roel; Jalvingh, Fedor; Bastiaanse, Yvonne

    Automated detection of un lled pauses in speech of healthy and brain-damaged individuals Roelant Ossewaardea,b, Roel Jonkersa, Fedor Jalvingha,c, Roelien Bastiaansea aCenter for Language and Cognition, University of Groningen; bInstitute for ICT, HU University of Applied Science, Utrecht; cSt.

  17. An Exploratory Study of Pauses in Computer-Assisted EFL Writing

    Science.gov (United States)

    Xu, Cuiqin; Ding, Yanren

    2014-01-01

    The advance of computer input log and screen-recording programs over the last two decades has greatly facilitated research into the writing process in real time. Using Inputlog 4.0 and Camtasia 6.0 to record the writing process of 24 Chinese EFL writers in an argumentative task, this study explored L2 writers' pausing patterns in computer-assisted…

  18. Impact of Typical Aging and Parkinson's Disease on the Relationship among Breath Pausing, Syntax, and Punctuation

    Science.gov (United States)

    Huber, Jessica E.; Darling, Meghan; Francis, Elaine J.; Zhang, Dabao

    2012-01-01

    Purpose: The present study examines the impact of typical aging and Parkinson's disease (PD) on the relationship among breath pausing, syntax, and punctuation. Method: Thirty young adults, 25 typically aging older adults, and 15 individuals with PD participated. Fifteen participants were age- and sex-matched to the individuals with PD.…

  19. Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)

    Science.gov (United States)

    Yunusova, Yana; Graham, Naida L.; Shellikeri, Sanjana; Phuong, Kent; Kulkarni, Madhura; Rochon, Elizabeth; Tang-Wai, David F.; Chow, Tiffany W.; Black, Sandra E.; Zinman, Lorne H.; Green, Jordan R.

    2016-01-01

    Objective This study examines reading aloud in patients with amyotrophic lateral sclerosis (ALS) and those with frontotemporal dementia (FTD) in order to determine whether differences in patterns of speaking and pausing exist between patients with primary motor vs. primary cognitive-linguistic deficits, and in contrast to healthy controls. Design 136 participants were included in the study: 33 controls, 85 patients with ALS, and 18 patients with either the behavioural variant of FTD (FTD-BV) or progressive nonfluent aphasia (FTD-PNFA). Participants with ALS were further divided into 4 non-overlapping subgroups—mild, respiratory, bulbar (with oral-motor deficit) and bulbar-respiratory—based on the presence and severity of motor bulbar or respiratory signs. All participants read a passage aloud. Custom-made software was used to perform speech and pause analyses, and this provided measures of speaking and articulatory rates, duration of speech, and number and duration of pauses. These measures were statistically compared in different subgroups of patients. Results The results revealed clear differences between patient groups and healthy controls on the passage reading task. A speech-based motor function measure (i.e., articulatory rate) was able to distinguish patients with bulbar ALS or FTD-PNFA from those with respiratory ALS or FTD-BV. Distinguishing the disordered groups proved challenging based on the pausing measures. Conclusions and Relevance This study demonstrated the use of speech measures in the identification of those with an oral-motor deficit, and showed the usefulness of performing a relatively simple reading test to assess speech versus pause behaviors across the ALS—FTD disease continuum. The findings also suggest that motor speech assessment should be performed as part of the diagnostic workup for patients with FTD. PMID:26789001

  20. Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS and Frontotemporal Dementia (FTD.

    Directory of Open Access Journals (Sweden)

    Yana Yunusova

    Full Text Available This study examines reading aloud in patients with amyotrophic lateral sclerosis (ALS and those with frontotemporal dementia (FTD in order to determine whether differences in patterns of speaking and pausing exist between patients with primary motor vs. primary cognitive-linguistic deficits, and in contrast to healthy controls.136 participants were included in the study: 33 controls, 85 patients with ALS, and 18 patients with either the behavioural variant of FTD (FTD-BV or progressive nonfluent aphasia (FTD-PNFA. Participants with ALS were further divided into 4 non-overlapping subgroups--mild, respiratory, bulbar (with oral-motor deficit and bulbar-respiratory--based on the presence and severity of motor bulbar or respiratory signs. All participants read a passage aloud. Custom-made software was used to perform speech and pause analyses, and this provided measures of speaking and articulatory rates, duration of speech, and number and duration of pauses. These measures were statistically compared in different subgroups of patients.The results revealed clear differences between patient groups and healthy controls on the passage reading task. A speech-based motor function measure (i.e., articulatory rate was able to distinguish patients with bulbar ALS or FTD-PNFA from those with respiratory ALS or FTD-BV. Distinguishing the disordered groups proved challenging based on the pausing measures.This study demonstrated the use of speech measures in the identification of those with an oral-motor deficit, and showed the usefulness of performing a relatively simple reading test to assess speech versus pause behaviors across the ALS-FTD disease continuum. The findings also suggest that motor speech assessment should be performed as part of the diagnostic workup for patients with FTD.

  1. Calcium Imaging Reveals Coordinated Simple Spike Pauses in Populations of Cerebellar Purkinje Cells

    Directory of Open Access Journals (Sweden)

    Jorge E. Ramirez

    2016-12-01

    Full Text Available The brain’s control of movement is thought to involve coordinated activity between cerebellar Purkinje cells. The results reported here demonstrate that somatic Ca2+ imaging is a faithful reporter of Na+-dependent “simple spike” pauses and enables us to optically record changes in firing rates in populations of Purkinje cells in brain slices and in vivo. This simultaneous calcium imaging of populations of Purkinje cells reveals a striking spatial organization of pauses in Purkinje cell activity between neighboring cells. The source of this organization is shown to be the presynaptic gamma-Aminobutyric acid producing (GABAergic network, and blocking ionotropic gamma-Aminobutyric acid receptor (GABAARs abolishes the synchrony. These data suggest that presynaptic interneurons synchronize (inactivity between neighboring Purkinje cells, and thereby maximize their effect on downstream targets in the deep cerebellar nuclei.

  2. Study of the dark pause phenomenon in a low cost exploding wire experiment

    International Nuclear Information System (INIS)

    Bressa, R.; Chatelain, G.; Lester, M.; Pouzo, J.

    1988-01-01

    A low cost exploding wire experiment is described and several aspects of the phenomenology in this type of plasmas are researched. Plasma photographies with high time resolution are obtained with a non-expensive Kerr cell switching system. The research is centered in the study of the dark pause phenomenon and the experimental results are interpreted using a very simple model. (author). 3 refs, 12 figs

  3. Applying pause analysis to explore cognitive processes in the copying of sentences by second language users

    OpenAIRE

    Zulkifli, Putri Afzan Maria Binti

    2013-01-01

    Pause analysis is a method that investigates processes of writing by measuring the amount of time between pen strokes. It provides the field of second language studies with a means to explore the cognitive processes underpinning the nature of writing. This study examined the potential of using free handwritten copying of sentences as a means of investigating components of the cognitive processes of adults who have English as their Second Language (ESL).\\ud \\ud A series of one pilot and three ...

  4. Balloon Dilatation of Pediatric Subglottic Laryngeal Stenosis during the Artificial Apneic Pause: Experience in 5 Children

    Directory of Open Access Journals (Sweden)

    J. Lisý

    2014-01-01

    Full Text Available Introduction. Balloon dilatation is a method of choice for treatment of laryngeal stenosis in children. The aim of procedure in apneic pause is to avoid new insertion of tracheostomy cannula. Patients and Methods. The authors performed balloon dilatation of subglottic laryngeal strictures (SGS in 5 children (3 girls and 2 boys without tracheotomy. Two of them with traumatic and inflammatory SGS had a tracheal cannula removed in the past. The other 3 children with postintubation SGS had never had a tracheostomy before. The need for tracheostomy due to worsening stridor was imminent for all of them. Results. The total of seven laryngeal dilatations by balloon esophagoplasty catheter in apneic pause was performed in the 5 children. The procedure averted the need for tracheostomy placement in 4 of them (80%. Failure of dilatation in girl with traumatic stenosis and concomitant severe obstructive lung disease led to repeated tracheostomy. Conclusion. Balloon dilatation of laryngeal stricture could be done in the absence of tracheostomy in apneic pause. Dilatation averted threatening tracheostomy in all except one case. Early complication after the procedure seems to be a negative prognostic factor for the outcome of balloon dilatation.

  5. Encounter rates and swimming behavior of pause-travel and cruise larval fish predators in calm and turbulent laboratory environments

    DEFF Research Database (Denmark)

    MacKenzie, Brian; Kiørboe, Thomas

    1995-01-01

    measure of prey encounter rate in unsatiated larvae) were significantly higher in turbulent than in calm water at low food abundances for two size groups of cod. The difference in cod attack position rate between calm and turbulent water was much less when prey was more abundant. Attack position rates...... of herring larvae were higher in turbulent water than in calm water, but the difference was not significant. Interspecific differences in swimming and pausing behavior were related to differences in prey search strategy used by the two species (cod: pause-travel; herring: cruise). We used a newly developed...... search model for pause-travel predators in calm and turbulent environments to compare encounter rates for predators using cruise and pause-travel search strategies. Encounter rates for cod and herring larvae, estimated with respective search models, were similar in calm and low turbulence water; at high...

  6. Interword and intraword pause threshold in the writing of texts by children and adolescents : a methodological approach

    Directory of Open Access Journals (Sweden)

    Florence eChenu

    2014-03-01

    Full Text Available Writing words in real life involves setting objectives, imagining a recipient, translating ideas into linguistic forms, managing grapho-motor gestures, etc. Understanding writing requires observation of the processes as they occur in real time. Analysis of pauses is one of the preferred methods for accessing the dynamics of writing and is based on the idea that pauses are behavioral correlates of cognitive processes. However, there is a need to clarify what we are observing when studying pause phenomena, as we will argue in the first section. This taken into account, the study of pause phenomena can be considered following two approaches. A first approach, driven by temporality, would define a threshold and observe where pauses, e.g. scriptural inactivity occurs. A second approach, linguistically driven, would define structural units and look for scriptural inactivity at the boundaries of these units or within these units. Taking a temporally driven approach, we present two methods which aim at the automatic identification of scriptural inactivity which is most likely not attributable to grapho-motor management in texts written by children and adolescents using digitizing tablets in association with Eye and Pen© (Chesnet & Alamargot, 2005. The first method is purely statistical and is based on the idea that the distribution of pauses exhibits different Gaussian components each of them corresponding to a different type of pause. After having reviewed the limits of this statistical method, we present a second method based on writing dynamics which attempts to identify breaking points in the writing dynamics rather than relying only on pause duration. This second method needs to be refined to overcome the fact that calculation is impossible when there is insufficient data which is often the case when working with young scriptors.

  7. Pausing precarity

    NARCIS (Netherlands)

    Gloerich, I.; Dovey, M.D.S.; Rasch, M.D.

    2017-01-01

    What does it mean to be precarious, and who self-identifies as part of the precariat? Is it a political position? And if so, how can precariats start to organize themselves? In this first episode of the Zero Infinite podcast we discuss precarity, anti-austerity and work through interviews with Alex

  8. Modular Organization of the NusA- and NusG-Stimulated RNA Polymerase Pause Signal That Participates in the Bacillus subtilis trp Operon Attenuation Mechanism.

    Science.gov (United States)

    Mondal, Smarajit; Yakhnin, Alexander V; Babitzke, Paul

    2017-07-15

    The Bacillus subtilis trpEDCFBA operon is regulated by a transcription attenuation mechanism in which tryptophan-activated TRAP binds to the nascent transcript and blocks the formation of an antiterminator structure such that the formation of an overlapping intrinsic terminator causes termination in the 5' untranslated region (5' UTR). In the absence of bound TRAP, the antiterminator forms and transcription continues into the trp genes. RNA polymerase pauses at positions U107 and U144 in the 5' UTR. The general transcription elongation factors NusA and NusG stimulate pausing at both positions. NusG-stimulated pausing at U144 requires sequence-specific contacts with a T tract in the nontemplate DNA (ntDNA) strand within the paused transcription bubble. Pausing at U144 participates in a trpE translation repression mechanism. Since U107 just precedes the critical overlap between the antiterminator and terminator structures, pausing at this position is thought to participate in attenuation. Here we carried out in vitro pausing and termination experiments to identify components of the U107 pause signal and to determine whether pausing affects the termination efficiency in the 5' UTR. We determined that the U107 and U144 pause signals are organized in a modular fashion containing distinct RNA hairpin, U-tract, and T-tract components. NusA-stimulated pausing was affected by hairpin strength and the U-tract sequence, whereas NusG-stimulated pausing was affected by hairpin strength and the T-tract sequence. We also determined that pausing at U107 results in increased TRAP-dependent termination in the 5' UTR, implying that NusA- and NusG-stimulated pausing participates in the trp operon attenuation mechanism by providing additional time for TRAP binding. IMPORTANCE The expression of several bacterial operons is controlled by regulated termination in the 5' untranslated region (5' UTR). Transcription attenuation is defined as situations in which the binding of a regulatory

  9. Steady-state structural fluctuation is a predictor of the necessity of pausing-mediated co-translational folding for small proteins.

    Science.gov (United States)

    Huang, Wenxi; Liu, Wanting; Jin, Jingjie; Xiao, Qilan; Lu, Ruibin; Chen, Wei; Xiong, Sheng; Zhang, Gong

    2018-03-25

    Translational pausing coordinates protein synthesis and co-translational folding. It is a common factor that facilitates the correct folding of large, multi-domain proteins. For small proteins, pausing sites rarely occurs in the gene body, and the 3'-end pausing sites are only essential for the folding of a fraction of proteins. The determinant of the necessity of the pausings remains obscure. In this study, we demonstrated that the steady-state structural fluctuation is a predictor of the necessity of pausing-mediated co-translational folding for small proteins. Validated by experiments with 5 model proteins, we found that the rigid protein structures do not, while the flexible structures do need 3'-end pausings to fold correctly. Therefore, rational optimization of translational pausing can improve soluble expression of small proteins with flexible structures, but not the rigid ones. The rigidity of the structure can be quantitatively estimated in silico using molecular dynamic simulation. Nevertheless, we also found that the translational pausing optimization increases the fitness of the expression host, and thus benefits the recombinant protein production, independent from the soluble expression. These results shed light on the structural basis of the translational pausing and provided a practical tool for industrial protein fermentation. Copyright © 2017. Published by Elsevier Inc.

  10. A Pause-then-Cancel model of stopping: evidence from basal ganglia neurophysiology.

    Science.gov (United States)

    Schmidt, Robert; Berke, Joshua D

    2017-04-19

    Many studies have implicated the basal ganglia in the suppression of action impulses ('stopping'). Here, we discuss recent neurophysiological evidence that distinct hypothesized processes involved in action preparation and cancellation can be mapped onto distinct basal ganglia cell types and pathways. We examine how movement-related activity in the striatum is related to a 'Go' process and how going may be modulated by brief epochs of beta oscillations. We then describe how, rather than a unitary 'Stop' process, there appear to be separate, complementary 'Pause' and 'Cancel' mechanisms. We discuss the implications of these stopping subprocesses for the interpretation of the stop-signal reaction time-in particular, some activity that seems too slow to causally contribute to stopping when assuming a single Stop processes may actually be fast enough under a Pause-then-Cancel model. Finally, we suggest that combining complementary neural mechanisms that emphasize speed or accuracy respectively may serve more generally to optimize speed-accuracy trade-offs.This article is part of the themed issue 'Movement suppression: brain mechanisms for stopping and stillness'. © 2017 The Author(s).

  11. Maracatus Solar e Reis de Paus: tradição e modernidade no carnaval de rua em Fortaleza

    OpenAIRE

    Silva, Roberto Antônio de Sousa da

    2013-01-01

    Trata-se de um estudo etnográfico e comparativo dos Maracatus Solar (2006) e Reis de Paus (1960), cujo objetivo foi verificar o que existe de antigo e tradicional no novo maracatu praticado pela agremiação Solar e, em contrapartida, o que existe de novo ou moderno no velho maracatu ritualizado pela agremiação Reis de Paus. Cabe ressaltar que por meio deste estudo de caso pretendeu-se também observar etnograficamente e compreender melhor os processos de rupturas e continuidades ...

  12. Effect of Continuous Current during Pauses between Successive Strokes on the Decay of the Lightning Channel

    International Nuclear Information System (INIS)

    Aleksandrov, N.L.; Bazelyan, E.M.; Shneider, M. N.

    2000-01-01

    A one-dimensional model is used to study the dynamics of the hydrodynamic parameters of the lightning channel in the return stroke and after the pulse current is damped. The effect of the continuous residual electric current during pauses between the successive strokes on the plasma cooling in the channel is analyzed. It is shown that a continuous electric current, which is several orders of magnitude lower than the peak current in the return stroke, is capable of maintaining the channel conductivity. This effect cannot be explained merely by Joule heating but is largely governed by the fact that the turbulent heat transport is substantially suppressed. In this case, even a continuous current as low as 50-100 A is capable of maintaining the conductivity of the lightning channel at a level at which only M-components can develop in the channel rather than the dart leader of the subsequent stroke

  13. A Diagnostic Marker to Discriminate Childhood Apraxia of Speech from Speech Delay: IV. the Pause Marker Index

    Science.gov (United States)

    Shriberg, Lawrence D.; Strand, Edythe A.; Fourakis, Marios; Jakielski, Kathy J.; Hall, Sheryl D.; Karlsson, Heather B.; Mabie, Heather L.; McSweeny, Jane L.; Tilkens, Christie M.; Wilson, David L.

    2017-01-01

    Purpose: Three previous articles provided rationale, methods, and several forms of validity support for a diagnostic marker of childhood apraxia of speech (CAS), termed the pause marker (PM). Goals of the present article were to assess the validity and stability of the PM Index (PMI) to scale CAS severity. Method: PM scores and speech, prosody,…

  14. A Diagnostic Marker to Discriminate Childhood Apraxia of Speech from Speech Delay: II. Validity Studies of the Pause Marker

    Science.gov (United States)

    Shriberg, Lawrence D.; Strand, Edythe A.; Fourakis, Marios; Jakielski, Kathy J.; Hall, Sheryl D.; Karlsson, Heather B.; Mabie, Heather L.; McSweeny, Jane L.; Tilkens, Christie M.; Wilson, David L.

    2017-01-01

    Purpose: The purpose of this 2nd article in this supplement is to report validity support findings for the Pause Marker (PM), a proposed single-sign diagnostic marker of childhood apraxia of speech (CAS). Method: PM scores and additional perceptual and acoustic measures were obtained from 296 participants in cohorts with idiopathic and…

  15. Interventions for Echolalic Behaviour for Children with Autism: A Review of Verbal Prompts and the Cues Pause Point Procedure.

    Science.gov (United States)

    Kavon, Nicole M.; McLaughlin, T. F.

    1995-01-01

    This paper examines behavior interventions for echolalic behavior in children with autism, including verbal prompting (focusing on the echolalic behavior itself) and the cues-pause-point procedure (which employs the child's prerequisite skills to teach correct verbal responses). A review of the literature indicated that both techniques were…

  16. A Diagnostic Marker to Discriminate Childhood Apraxia of Speech from Speech Delay: I. Development and Description of the Pause Marker

    Science.gov (United States)

    Shriberg, Lawrence D.; Strand, Edythe A.; Fourakis, Marios; Jakielski, Kathy J.; Hall, Sheryl D.; Karlsson, Heather B.; Mabie, Heather L.; McSweeny, Jane L.; Tilkens, Christie M.; Wilson, David L.

    2017-01-01

    Purpose: The goal of this article (PM I) is to describe the rationale for and development of the Pause Marker (PM), a single-sign diagnostic marker proposed to discriminate early or persistent childhood apraxia of speech from speech delay. Method: The authors describe and prioritize 7 criteria with which to evaluate the research and clinical…

  17. Prediction of Audience Response from Spoken Sequences, Speech Pauses and Co-speech Gestures in Humorous Discourse by Barack Obama

    DEFF Research Database (Denmark)

    Navarretta, Costanza

    2017-01-01

    president mocks himself, his collaborators, political adversary and the press corps making the audience react with cheers, laughter and/or applause. The results of the prediction experiment demonstrate that information about spoken sequences, pauses and co-speech gestures by Obama can be used to predict...

  18. An Investigation of Read Speech of Arabic Students Learning Turkish as a Second Language in Terms of Stress and Pause

    Science.gov (United States)

    Derman, Serdar; Bardakçi, Mehmet; Öztürk, Mustafa Serkan

    2017-01-01

    Suprasegmental features are essential in conveying meaning; however, they are one of the neglected topics in teaching Turkish as a foreign/second language. This paper aims to examine read speech by Arabic students learning Turkish as a second language and describe their read speech in terms of stress and pause. Within this framework, 34 Syrian…

  19. Filled pause refinement based on the pronunciation probability for lecture speech.

    Directory of Open Access Journals (Sweden)

    Yan-Hua Long

    Full Text Available Nowadays, although automatic speech recognition has become quite proficient in recognizing or transcribing well-prepared fluent speech, the transcription of speech that contains many disfluencies remains problematic, such as spontaneous conversational and lecture speech. Filled pauses (FPs are the most frequently occurring disfluencies in this type of speech. Most recent studies have shown that FPs are widely believed to increase the error rates for state-of-the-art speech transcription, primarily because most FPs are not well annotated or provided in training data transcriptions and because of the similarities in acoustic characteristics between FPs and some common non-content words. To enhance the speech transcription system, we propose a new automatic refinement approach to detect FPs in British English lecture speech transcription. This approach combines the pronunciation probabilities for each word in the dictionary and acoustic language model scores for FP refinement through a modified speech recognition forced-alignment framework. We evaluate the proposed approach on the Reith Lectures speech transcription task, in which only imperfect training transcriptions are available. Successful results are achieved for both the development and evaluation datasets. Acoustic models trained on different styles of speech genres have been investigated with respect to FP refinement. To further validate the effectiveness of the proposed approach, speech transcription performance has also been examined using systems built on training data transcriptions with and without FP refinement.

  20. R A Cowley, the "Golden Hour," the "Momentary Pause," and the "Third Space".

    Science.gov (United States)

    Clark, David E

    2017-12-01

    R Adams Cowley (1917-1991), the Baltimore thoracic and trauma surgeon, was an outstanding politician and promoter of emergency medical services. His skills included the effective use of language, for example, identifying the critical time immediately after injury as a "golden hour," and describing shock as a "momentary pause in the act of death." Conversely, Cowley avoided the tendency of some contemporaries to justify massive crystalloid infusion by invoking a "third space." Cowley is often assumed to have originated the first two phrases, but, in fact, their histories go back at least to the 19th century and illustrate the development of surgical science. The "third space" is often assumed to have originated with Cowley's contemporary, Tom Shires (1925-2007), but, in fact, neither of them used the phrase to describe Shires' controversial theories about an extracellular fluid deficit after trauma. Reviewing the actual etymology of these terms may help clarify the history of the underlying scientific ideas and enable more effective communication in the future.

  1. Counting to ten milliseconds: low-anger, but not high-anger, individuals pause following negative evaluations.

    Science.gov (United States)

    Robinson, Michael D; Wilkowski, Benjamin M; Meier, Brian P; Moeller, Sara K; Fetterman, Adam K

    2012-01-01

    Low-anger individuals are less reactive, both emotionally and behaviourally, to a large variety of situational primes to anger and aggression. Why this is so, from an affective processing perspective, has been largely conjectural. Four studies (total N=270) sought to link individual differences in anger to tendencies exhibited in basic affective processing tasks. On the basis of motivational factors and considerations, it was hypothesised that negative evaluations would differentially activate a psychological alarm system at low levels of anger, resulting in a pause that should be evident in the speed of making subsequent evaluations. Just such a pattern was evident in all studies. By contrast, high-anger individuals did not pause following their negative evaluations. In relation to this affective processing tendency, at least, dramatically different effects were observed among low- versus high-anger individuals. Implications for the personality-processing literature, theories of trait anger, and fast-acting regulatory processes are discussed.

  2. Dwell-Time Distribution, Long Pausing and Arrest of Single-Ribosome Translation through the mRNA Duplex.

    Science.gov (United States)

    Xie, Ping

    2015-10-09

    Proteins in the cell are synthesized by a ribosome translating the genetic information encoded on the single-stranded messenger RNA (mRNA). It has been shown that the ribosome can also translate through the duplex region of the mRNA by unwinding the duplex. Here, based on our proposed model of the ribosome translation through the mRNA duplex we study theoretically the distribution of dwell times of the ribosome translation through the mRNA duplex under the effect of a pulling force externally applied to the ends of the mRNA to unzip the duplex. We provide quantitative explanations of the available single molecule experimental data on the distribution of dwell times with both short and long durations, on rescuing of the long paused ribosomes by raising the pulling force to unzip the duplex, on translational arrests induced by the mRNA duplex and Shine-Dalgarno(SD)-like sequence in the mRNA. The functional consequences of the pauses or arrests caused by the mRNA duplex and the SD sequence are discussed and compared with those obtained from other types of pausing, such as those induced by "hungry" codons or interactions of specific sequences in the nascent chain with the ribosomal exit tunnel.

  3. Supplementary Motor Area Activation in Disfluency Perception : An fMRI Study of Listener Neural Responses to Spontaneously Produced Unfilled and Filled Pauses

    OpenAIRE

    Eklund, Robert; Ingvar, Martin

    2016-01-01

    Spontaneously produced Unfilled Pauses (UPs) and Filled Pauses (FPs) were played to subjects in an fMRI experiment. For both stimuli increased activity was observed in the Primary Auditory Cortex (PAC). However, FPs, but not UPs, elicited modulation in the Supplementary Motor Area (SMA), Brodmann Area 6. Our results provide neurocognitive confirmation of the alleged difference between FPs and other kinds of speech disfluency and could also provide a partial explanation for the previously repo...

  4. TbRGG2 facilitates kinetoplastid RNA editing initiation and progression past intrinsic pause sites.

    Science.gov (United States)

    Ammerman, Michelle L; Presnyak, Vladimir; Fisk, John C; Foda, Bardees M; Read, Laurie K

    2010-11-01

    TbRGG2 is an essential kinetoplastid RNA editing accessory factor that acts specifically on pan-edited RNAs. To understand the mechanism of TbRGG2 action, we undertook an in-depth analysis of edited RNA populations in TbRGG2 knockdown cells and an in vitro examination of the biochemical activities of the protein. We demonstrate that TbRGG2 down-regulation more severely impacts editing at the 5' ends of pan-edited RNAs than at their 3' ends. The initiation of editing is reduced to some extent in TbRGG2 knockdown cells. In addition, TbRGG2 plays a post-initiation role as editing becomes stalled in TbRGG2-depleted cells, resulting in an overall decrease in the 3' to 5' progression of editing. Detailed analyses of edited RNAs from wild-type and TbRGG2-depleted cells reveal that TbRGG2 facilitates progression of editing past intrinsic pause sites that often correspond to the 3' ends of cognate guide RNAs (gRNAs). In addition, noncanonically edited junction regions are either absent or significantly shortened in TbRGG2-depleted cells, consistent with impaired gRNA transitions. Sequence analysis further suggests that TbRGG2 facilitates complete utilization of certain gRNAs. In vitro RNA annealing and in vivo RNA unwinding assays demonstrate that TbRGG2 can modulate RNA-RNA interactions. Collectively, these data are consistent with a model in which TbRGG2 facilitates initiation and 3' to 5' progression of editing through its ability to affect gRNA utilization, both during the transition between specific gRNAs and during usage of certain gRNAs.

  5. Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.

    Directory of Open Access Journals (Sweden)

    Xiao P Peng

    2018-01-01

    Full Text Available Smc5/6, a member of the conserved SMC family of complexes, is essential for growth in most organisms. Its exact functions in a mitotic cell cycle are controversial, as chronic Smc5/6 loss-of-function alleles produce varying phenotypes. To circumvent this issue, we acutely depleted Smc5/6 in budding yeast and determined the first cell cycle consequences of Smc5/6 removal. We found a striking primary defect in replication of the ribosomal DNA (rDNA array. Each rDNA repeat contains a programmed replication fork barrier (RFB established by the Fob1 protein. Fob1 removal improves rDNA replication in Smc5/6 depleted cells, implicating Smc5/6 in the management of programmed fork pausing. A similar improvement is achieved by removing the DNA helicase Mph1 whose recombinogenic activity can be inhibited by Smc5/6 under DNA damage conditions. DNA 2D gel analyses further show that Smc5/6 loss increases recombination structures at RFB regions; moreover, mph1∆ and fob1∆ similarly reduce this accumulation. These findings point to an important mitotic role for Smc5/6 in restraining recombination events when protein barriers in rDNA stall replication forks. As rDNA maintenance influences multiple essential cellular processes, Smc5/6 likely links rDNA stability to overall mitotic growth.

  6. Adolescent girls in Denmark use oral contraceptives at an increasingly young age, and with more pauses and shifts

    DEFF Research Database (Denmark)

    Løkkegaard, Ellen; Nielsen, A. K.

    2014-01-01

    was to describe the use of hormonal contraceptives among the Danish adolescent female population, focusing on age, period and cohort effects and including types of hormonal contraceptives. MATERIAL AND METHODS: All women aged 14-50 years during the 1995-2012 period were identified through the Central Person...... Register. Furthermore, the National Registry of Medicinal Products Statistics provided information on redeemed prescriptions for hormonal contraceptives characterised by Anatomical-Therapeutic-Chemical (ATC) classification codes. RESULTS: At the age of 17 years, more than 50% of the Danish adolescent......, adolescent girls have more pauses and shifts between types of hormonal contraceptives. Since 2010 there has been a shift toward use of second generation oral contraceptives away from third and fourth generation contraceptives. CONCLUSION: Adolescent girls tend to initiate their use of oral contraceptives...

  7. GSK3β is involved in the relief of mitochondria pausing in a Tau-dependent manner.

    Directory of Open Access Journals (Sweden)

    María Llorens-Martín

    Full Text Available Mitochondrial trafficking deficits have been implicated in the pathogenesis of several neurological diseases, including Alzheimer's disease (AD. The Ser/Thre kinase GSK3β is believed to play a fundamental role in AD pathogenesis. Given that GSK3β substrates include Tau protein, here we studied the impact of GSK3β on mitochondrial trafficking and its dependence on Tau protein. Overexpression of GSK3β in neurons resulted in an increase in motile mitochondria, whereas a decrease in the activity of this kinase produced an increase in mitochondria pausing. These effects were dependent on Tau proteins, as Tau (-/- neurons did not respond to distinct GSK3β levels. Furthermore, differences in GSK3β expression did not affect other parameters like mitochondria velocity or mitochondria run length. We conclude that GSK3B activity regulates mitochondrial axonal trafficking largely in a Tau-dependent manner.

  8. Postreinforcement Pause Duration Varies within a Session and with a Variable Response Requirement but Not as a Function of Prior Revolutions

    Science.gov (United States)

    Belke, Terry W.

    2011-01-01

    The current study examined the variables that influence postreinforcement pause (PRP) duration in rats when wheel running serves as the reinforcing consequence. The relationship between revolutions and PRP duration when revolutions were manipulated within a session and the effect of changing the response requirement from fixed to variable on PRP…

  9. A Diagnostic Marker to Discriminate Childhood Apraxia of Speech from Speech Delay: III. Theoretical Coherence of the Pause Marker with Speech Processing Deficits in Childhood Apraxia of Speech

    Science.gov (United States)

    Shriberg, Lawrence D.; Strand, Edythe A.; Fourakis, Marios; Jakielski, Kathy J.; Hall, Sheryl D.; Karlsson, Heather B.; Mabie, Heather L.; McSweeny, Jane L.; Tilkens, Christie M.; Wilson, David L.

    2017-01-01

    Purpose: Previous articles in this supplement described rationale for and development of the pause marker (PM), a diagnostic marker of childhood apraxia of speech (CAS), and studies supporting its validity and reliability. The present article assesses the theoretical coherence of the PM with speech processing deficits in CAS. Method: PM and other…

  10. A Comparison between the Occurrence of Pauses, Repetitions and Recasts under Conditions of Face-to-Face and Computer-Mediated Communication: A Preliminary Study

    Science.gov (United States)

    Cabaroglu, Nese; Basaran, Suleyman; Roberts, Jon

    2010-01-01

    This study compares pauses, repetitions and recasts in matched task interactions under face-to-face and computer-mediated conditions. Six first-year English undergraduates at a Turkish University took part in Skype-based voice chat with a native speaker and face-to-face with their instructor. Preliminary quantitative analysis of transcripts showed…

  11. Physiologic effects of alveolar recruitment and inspiratory pauses during moderately-high-frequency ventilation delivered by a conventional ventilator in a severe lung injury model.

    Directory of Open Access Journals (Sweden)

    Ricardo Luiz Cordioli

    Full Text Available To investigate whether performing alveolar recruitment or adding inspiratory pauses could promote physiologic benefits (VT during moderately-high-frequency positive pressure ventilation (MHFPPV delivered by a conventional ventilator in a porcine model of severe acute respiratory distress syndrome (ARDS.Prospective experimental laboratory study with eight pigs. Induction of acute lung injury with sequential pulmonary lavages and injurious ventilation was initially performed. Then, animals were ventilated on a conventional mechanical ventilator with a respiratory rate (RR = 60 breaths/minute and PEEP titrated according to ARDS Network table. The first two steps consisted of a randomized order of inspiratory pauses of 10 and 30% of inspiratory time. In final step, we removed the inspiratory pause and titrated PEEP, after lung recruitment, with the aid of electrical impedance tomography. At each step, PaCO2 was allowed to stabilize between 57-63 mmHg for 30 minutes.The step with RR of 60 after lung recruitment had the highest PEEP when compared with all other steps (17 [16,19] vs 14 [10, 17]cmH2O, but had lower driving pressures (13 [13,11] vs 16 [14, 17]cmH2O, higher P/F ratios (212 [191,243] vs 141 [105, 184] mmHg, lower shunt (23 [20, 23] vs 32 [27, 49]%, lower dead space ventilation (10 [0, 15] vs 30 [20, 37]%, and a more homogeneous alveolar ventilation distribution. There were no detrimental effects in terms of lung mechanics, hemodynamics, or gas exchange. Neither the addition of inspiratory pauses or the alveolar recruitment maneuver followed by decremental PEEP titration resulted in further reductions in VT.During MHFPPV set with RR of 60 bpm delivered by a conventional ventilator in severe ARDS swine model, neither the inspiratory pauses or PEEP titration after recruitment maneuver allowed reduction of VT significantly, however the last strategy decreased driving pressures and improved both shunt and dead space.

  12. Effect of duration of the pause single-phase auto-reclosing on electro-power transmission capacitance

    Directory of Open Access Journals (Sweden)

    Krasil'nikova Tatyana

    2017-01-01

    Full Text Available This paper discusses the problem associated with accidents in the aerial line (AL ultra-high voltage (UHV due to its big length. In lines with a voltage of 500-1150 kV the overwhelming proportion of trips (98% is caused by single-phase short circuit (SPSC. A substantial portion (70% single-phase short circuits is erratic arc accidents which can be successfully eliminated in a high-speed auto-reclosing (HSAR or single-phase auto-reclosing (SPAR. Success single-phase auto-reclosing (SPAR at liquidation by single-phase short circuit (SPSC, on the one hand, is determined by the characteristics of the secondary arc current, and on the other hand the effectiveness of ways to reduce secondary arc current and recovery voltage development. The minimum dead time, at a HSAR it is usually taken as 0.5 s., at single-phase autoreclosing (SPAR it depends on the current value of the arc support is in the range of 0.5-3.0 s. The article shows high efficiency of use single-phase auto reclosing (SPAR at liquidation SPSC in a single-chain AL voltage of 500 kV, the dependence of the bandwidth of transmission in maintaining the dynamic stability from the length of the pause SPAR.

  13. Safety first: oilfield jobs sometimes go begging, but smart recruits pause for some training

    Energy Technology Data Exchange (ETDEWEB)

    Mowers, J.

    2000-05-01

    Occupational health and safety training available to prospective oilfield workers through the Petroleum Industry Training Service is discussed. The pre-employment program at PITS has been developed by the Canadian Association of Oilwell Drilling Contractors; about 240 students go through the program in an ordinary year. Training is done at the Nisku Campus of PITS and a second rig is waiting on standby for training at the site of the Leduc discovery near Devon. With both rigs in action, PITS will have the capacity to train up to 1,000 new hands a year. The course is also offered in Calgary where PITS is headquartered. The training is rigorous and hands-on; when not on the rig floor, students learn about off-the-rig jobs, such as mixing mud, packing gel, greasing, and digging ditches, in addition to more traditional 'book learning' about hydrogen sulphide, workplace hazardous materials, standard first aid and CPR. In addition to the pre-employment health and safety course, PITS also offers pre-employment programs for operators of production sites, including hands-on experience with an oil battery and gas plant at the Nisku campus. The pre-employment programs are supplementary to some 120 specialized course offered by PITS at Calgary and at numerous colleges and field locations.

  14. StpA and Hha stimulate pausing by RNA polymerase by promoting DNA-DNA bridging of H-NS filaments.

    Science.gov (United States)

    Boudreau, Beth A; Hron, Daniel R; Qin, Liang; van der Valk, Ramon A; Kotlajich, Matthew V; Dame, Remus T; Landick, Robert

    2018-06-20

    In enterobacteria, AT-rich horizontally acquired genes, including virulence genes, are silenced through the actions of at least three nucleoid-associated proteins (NAPs): H-NS, StpA and Hha. These proteins form gene-silencing nucleoprotein filaments through direct DNA binding by H-NS and StpA homodimers or heterodimers. Both linear and bridged filaments, in which NAPs bind one or two DNA segments, respectively, have been observed. Hha can interact with H-NS or StpA filaments, but itself lacks a DNA-binding domain. Filaments composed of H-NS alone can inhibit transcription initiation and, in the bridged conformation, slow elongating RNA polymerase (RNAP) by promoting backtracking at pause sites. How the other NAPs modulate these effects of H-NS is unknown, despite evidence that they help regulate subsets of silenced genes in vivo (e.g. in pathogenicity islands). Here we report that Hha and StpA greatly enhance H-NS-stimulated pausing by RNAP at 20°C. StpA:H-NS or StpA-only filaments also stimulate pausing at 37°C, a temperature at which Hha:H-NS or H-NS-only filaments have much less effect. In addition, we report that both Hha and StpA greatly stimulate DNA-DNA bridging by H-NS filaments. Together, these observations indicate that Hha and StpA can affect H-NS-mediated gene regulation by stimulating bridging of H-NS/DNA filaments.

  15. How laser damage resistance of HfO2/SiO2 optical coatings is affected by embedded contamination caused by pausing the deposition process

    Science.gov (United States)

    Field, Ella; Bellum, John; Kletecka, Damon

    2015-07-01

    Reducing contamination is essential for producing optical coatings with high resistance to laser damage. One aspect of this principle is to make every effort to limit long interruptions during the coating's deposition. Otherwise, contamination may accumulate during the pause and become embedded in the coating after the deposition is restarted, leading to a lower laser-induced damage threshold (LIDT). However, pausing a deposition is sometimes unavoidable, despite our best efforts. For example, a sudden hardware or software glitch may require hours or even overnight to solve. In order to broaden our understanding of the role of embedded contamination on LIDT, and determine whether a coating deposited under such non-ideal circumstances could still be acceptable, this study explores how halting a deposition overnight impacts the LIDT, and whether ion cleaning can be used to mitigate any negative effects on the LIDT. The coatings investigated are a beam splitter design for high reflection at 1054 nm and high transmission at 527 nm, at 22.5° angle of incidence in S-polarization. LIDT tests were conducted in the nanosecond regime.

  16. The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.

    Directory of Open Access Journals (Sweden)

    Karen S Hathcock

    Full Text Available T cell development occurs in the thymus and is critically dependent on productive TCRβ rearrangement and pre-TCR expression in DN3 cells. The requirement for pre-TCR expression results in the arrest of thymocytes at the DN3 stage (β checkpoint, which is uniquely permissive for V-DJβ recombination; only cells expressing pre-TCR survive and develop beyond the DN3 stage. In addition, the requirement for TCRβ rearrangement and pre-TCR expression enforces suppression of TCRβ rearrangement on a second allele, allelic exclusion, thus ensuring that each T cell expresses only a single TCRβ product. However, it is not known whether pre-TCR expression is essential for allelic exclusion or alternatively if allelic exclusion is enforced by developmental changes that can occur in the absence of pre-TCR. We asked if thymocytes that were differentiated without pre-TCR expression, and therefore without pause at the β checkpoint, would suppress all V-DJβ rearrangement. We previously reported that premature CD28 signaling in murine CD4(-CD8(- (DN thymocytes supports differentiation of CD4(+CD8(+ (DP cells in the absence of pre-TCR expression. The present study uses this model to define requirements for TCRβ rearrangement and allelic exclusion. We demonstrate that if cells exit the DN3 developmental stage before TCRβ rearrangement occurs, V-DJβ rearrangement never occurs, even in DP cells that are permissive for D-Jβ and TCRα rearrangement. These results demonstrate that pre-TCR expression is not essential for thymic differentiation to DP cells or for V-DJβ suppression. However, the requirement for pre-TCR signals and the exclusion of alternative stimuli such as CD28 enforce a developmental "pause" in early DN3 cells that is essential for productive TCRβ rearrangement to occur.

  17. Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle

    Directory of Open Access Journals (Sweden)

    Gabriele Büchel

    2017-12-01

    Full Text Available MYC proteins bind globally to active promoters and promote transcriptional elongation by RNA polymerase II (Pol II. To identify effector proteins that mediate this function, we performed mass spectrometry on N-MYC complexes in neuroblastoma cells. The analysis shows that N-MYC forms complexes with TFIIIC, TOP2A, and RAD21, a subunit of cohesin. N-MYC and TFIIIC bind to overlapping sites in thousands of Pol II promoters and intergenic regions. TFIIIC promotes association of RAD21 with N-MYC target sites and is required for N-MYC-dependent promoter escape and pause release of Pol II. Aurora-A competes with binding of TFIIIC and RAD21 to N-MYC in vitro and antagonizes association of TOP2A, TFIIIC, and RAD21 with N-MYC during S phase, blocking N-MYC-dependent release of Pol II from the promoter. Inhibition of Aurora-A in S phase restores RAD21 and TFIIIC binding to chromatin and partially restores N-MYC-dependent transcriptional elongation. We propose that complex formation with Aurora-A controls N-MYC function during the cell cycle.

  18. R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters.

    Science.gov (United States)

    Chen, Liang; Chen, Jia-Yu; Zhang, Xuan; Gu, Ying; Xiao, Rui; Shao, Changwei; Tang, Peng; Qian, Hao; Luo, Daji; Li, Hairi; Zhou, Yu; Zhang, Dong-Er; Fu, Xiang-Dong

    2017-11-16

    R-loop, a three-stranded RNA/DNA structure, has been linked to induced genome instability and regulated gene expression. To enable precision analysis of R-loops in vivo, we develop an RNase-H-based approach; this reveals predominant R-loop formation near gene promoters with strong G/C skew and propensity to form G-quadruplex in non-template DNA, corroborating with all biochemically established properties of R-loops. Transcription perturbation experiments further indicate that R-loop induction correlates to transcriptional pausing. Interestingly, we note that most mapped R-loops are each linked to a nearby free RNA end; by using a ribozyme to co-transcriptionally cleave nascent RNA, we demonstrate that such a free RNA end coupled with a G/C-skewed sequence is necessary and sufficient to induce R-loop. These findings provide a topological solution for RNA invasion into duplex DNA and suggest an order for R-loop initiation and elongation in an opposite direction to that previously proposed. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Glycogen synthase kinase-3beta and the p25 activator of cyclin dependent kinase 5 increase pausing of mitochondria in neurons.

    Science.gov (United States)

    Morel, M; Authelet, M; Dedecker, R; Brion, J P

    2010-06-02

    The complex bi-directional axoplasmic transport of mitochondria is essential for proper metabolic functioning of neurons and is controlled by phosphorylation. We have investigated by time-lapse imaging the effects of increased expression of glycogen synthase kinase-3beta (GSK-3beta) and of the p25 activator of cyclin dependent kinase 5 on mitochondria movements in mammalian cortical neurons and in PC12 cells. Both GSK-3beta and p25 increased the stationary behaviour of mitochondria in PC12 and in neurons, decreased their anterograde transport but did not affect the intrinsic velocities of mitochondria. The microtubule-associated tau proteins were more phosphorylated in GSK-3beta and p25 transfected neurons, but ultrastructural observation showed that these cells still contained microtubules and nocodazole treatment further reduced residual mitochondria movements in GSK-3beta or p25 transfected neurons, indicating that microtubule disruption was not the primary cause of increased mitochondrial stationary behaviour in GSK-3beta or p25 transfected neurons. Our results suggest that increased expression of GSK-3beta and p25 acted rather by decreasing the frequency of mitochondrial movements driven by molecular motors and that GSK-3beta and p25 might regulate these transports by controlling the time that mitochondria spend pausing, rather than their velocities. Copyright 2010 IBRO. Published by Elsevier Ltd. All rights reserved.

  20. TTaPP: Together Take a Pause and Ponder: A Critical Thinking Tool for Exploring the Public/Private Lives of Patients.

    Science.gov (United States)

    Kuhnel, Leslie

    2018-01-01

    The broad use of social networking and user-generated content has increased the online footprint of many individuals. A generation of healthcare professionals have grown up with online search activities as part of their everyday lives. Sites like Facebook, Twitter, and Instagram have given the public new ways to share intimate details about their public and private lives and the lives of their friends and families. As a result, careproviders have the ability to find out more about their patients with just the tap of a key or the click of a mouse. This type of online searching for patient information is known as patient-targeted googling or PTG. This article provides an overview of the emergence of PTG, identifies the potential benefits and possible pitfalls of engaging in PTG, and explores current ethical frameworks that guide decisions about PTG. The article describes the development of a critical thinking tool developed by the Behavioral Health Ethics Committee at CHI Health, that can serve as a best-practice model for other hospitals and health systems. Called TTaPP (Together Take a Pause and Ponder), this tool is designed to help healthcare professionals across settings practice collaborative critical thinking skills as they consider the ethical questions of whether or not to engage in PTG. Finally, this article suggests areas for further study, including ways to prompt collaboration and appropriate documentation by maximizing electronic medical records systems, exploring the effectiveness of the TTaPP tool as a way to promote a culture of collaborative critical thinking practices, and the attitudes of patients and the public regarding PTG. Copyright 2018 The Journal of Clinical Ethics. All rights reserved.

  1. Young children pause on phrase boundaries in self-paced music listening: The role of harmonic cues.

    Science.gov (United States)

    Kragness, Haley E; Trainor, Laurel J

    2018-05-01

    Proper segmentation of auditory streams is essential for understanding music. Many cues, including meter, melodic contour, and harmony, influence adults' perception of musical phrase boundaries. To date, no studies have examined young children's musical grouping in a production task. We used a musical self-pacing method to investigate (1) whether dwell times index young children's musical phrase grouping and, if so, (2) whether children dwell longer on phrase boundaries defined by harmonic cues specifically. In Experiment 1, we asked 3-year-old children to self-pace through chord progressions from Bach chorales (sequences in which metrical, harmonic, and melodic contour grouping cues aligned) by pressing a computer key to present each chord in the sequence. Participants dwelled longer on chords in the 8th position, which corresponded to phrase endings. In Experiment 2, we tested 3-, 4-, and 7-year-old children's sensitivity to harmonic cues to phrase grouping when metrical regularity cues and melodic contour cues were misaligned with the harmonic phrase boundaries. In this case, 7 and 4 year olds but not 3 year olds dwelled longer on harmonic phrase boundaries, suggesting that the influence of harmonic cues on phrase boundary perception develops substantially between 3 and 4 years of age in Western children. Overall, we show that the musical dwell time method is child-friendly and can be used to investigate various aspects of young children's musical understanding, including phrase grouping and harmonic knowledge. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  2. Effects of transcription ability and transcription mode on translation: Evidence from written compositions, language bursts and pauses when students in grades 4 to 9, with and without persisting dyslexia or dysgraphia, compose by pen or by keyboard

    Directory of Open Access Journals (Sweden)

    Scott F. Beers

    2017-06-01

    Full Text Available This study explored the effects of transcription on translation products and processes of adolescent students in grades 4 to 9 with and without persisting specific language disabilities in written language (SLDs—WL. To operationalize transcription ability (handwriting and spelling and transcription mode (by pen on digital tablet or by standard US keyboard, diagnostic groups contrasting in patterns of transcription ability were compared while composing autobiographical (personal narratives by handwriting or by keyboarding: Typically developing students (n=15, students with dyslexia (impaired word reading and spelling, n=20, and students with dysgraphia (impaired handwriting, n=19. They were compared on seven outcomes: total words composed, total composing time, words per minute, percent of spelling errors, average length of pauses, average number of pauses per minute, and average length of language bursts. They were also compared on automaticity of transcription modes—writing the alphabet from memory by handwriting or keyboarding (they could look at keys. Mixed ANOVAs yielded main effects for diagnostic group on percent of spelling errors, words per minute, and length of language burst. Main effects for transcription modes were found for automaticity of writing modes, total words composed, words per minute, and length of language bursts; there were no significant interactions. Regardless of mode, the dyslexia group had more spelling errors, showed a slower rate of composing, and produced shorter language bursts than the typical group. The total number of words, total time composing, words composed per minute, and pauses per minute were greater for keyboarding than handwriting, but length of language bursts was greater for handwriting. Implications of these results for conceptual models of composing and educational assessment practices are discussed.

  3. Genome-wide analysis of KAP1, the 7SK snRNP complex, and RNA polymerase II

    Directory of Open Access Journals (Sweden)

    Ryan P. McNamara

    2016-03-01

    Full Text Available The transition of RNA polymerase II (Pol II from transcription initiation into productive elongation in eukaryotic cells is regulated by the P-TEFb kinase, which phosphorylates the C-terminal domain of paused Pol II at promoter-proximal regions. Our recent study found that P-TEFb (in an inhibited state bound to the 7SK snRNP complex interacts with the KAP1/TRIM28 transcriptional regulator, and that KAP1 and the 7SK snRNP co-occupy most gene promoters containing paused Pol II. Here we provide a detailed experimental description and analysis of the ChIP-seq datasets that have been deposited into Gene Expression Omnibus (GEO: GS72622, so that independent groups can replicate and expand upon these findings. We propose these datasets would provide valuable information for researchers studying mechanisms of transcriptional regulation including Pol II pausing and pause release. Keywords: P-TEFb/7SK snRNP, KAP1, RNA polymerase II, ChIP-seq, Transcription elongation

  4. Validação de método para determinação das impurezas cascas e paus em café torrado e moído

    Directory of Open Access Journals (Sweden)

    Lumena Cunha Mendes

    Full Text Available Resumo A determinação de impurezas do café torrado e moído faz parte das análises que contribuem para assegurar o controle da qualidade do produto. O objetivo deste trabalho foi validar o procedimento metodológico de microscopia para detecção e quantificação das impurezas cascas e paus em café torrado e moído. O método baseou-se no princípio da extração de gordura do café com solvente orgânico, eliminação do pó fino por peneiração e determinação por catação pelo uso de microscópio estereoscópico. Setenta amostras de café torrado e moído coletadas em estabelecimentos comerciais de Belo Horizonte, MG, tiveram as análises duplicadas por três analistas, totalizando 420 determinações, com os resultados expressos em porcentagens das impurezas cascas e paus. Os coeficientes de variação em condições de repetibilidade variaram de 7,0% a 27,9%, sendo considerados satisfatórios para microscopia. O fator analista tem forte influência nos parâmetros de precisão e exatidão do método. O método mostrou-se preciso a partir da concentração de 0,2% de impurezas. A exatidão do método foi satisfatória com a recuperação estando numa faixa aceitável. As incertezas variaram com a faixa de concentração de impurezas e tenderam a ser inversamente proporcionais. O método foi considerado adequado para análise destas impurezas do café torrado e moído e tem potencial para ser indicado nos procedimentos de fiscalização.

  5. New insights into transcription fidelity: thermal stability of non-canonical structures in template DNA regulates transcriptional arrest, pause, and slippage.

    Science.gov (United States)

    Tateishi-Karimata, Hisae; Isono, Noburu; Sugimoto, Naoki

    2014-01-01

    The thermal stability and topology of non-canonical structures of G-quadruplexes and hairpins in template DNA were investigated, and the effect of non-canonical structures on transcription fidelity was evaluated quantitatively. We designed ten template DNAs: A linear sequence that does not have significant higher-order structure, three sequences that form hairpin structures, and six sequences that form G-quadruplex structures with different stabilities. Templates with non-canonical structures induced the production of an arrested, a slipped, and a full-length transcript, whereas the linear sequence produced only a full-length transcript. The efficiency of production for run-off transcripts (full-length and slipped transcripts) from templates that formed the non-canonical structures was lower than that from the linear. G-quadruplex structures were more effective inhibitors of full-length product formation than were hairpin structure even when the stability of the G-quadruplex in an aqueous solution was the same as that of the hairpin. We considered that intra-polymerase conditions may differentially affect the stability of non-canonical structures. The values of transcription efficiencies of run-off or arrest transcripts were correlated with stabilities of non-canonical structures in the intra-polymerase condition mimicked by 20 wt% polyethylene glycol (PEG). Transcriptional arrest was induced when the stability of the G-quadruplex structure (-ΔG°37) in the presence of 20 wt% PEG was more than 8.2 kcal mol(-1). Thus, values of stability in the presence of 20 wt% PEG are an important indicator of transcription perturbation. Our results further our understanding of the impact of template structure on the transcription process and may guide logical design of transcription-regulating drugs.

  6. Time to pause before the next step

    International Nuclear Information System (INIS)

    Siemon, R.E.

    1998-01-01

    Many scientists, who have staunchly supported ITER for years, are coming to realize it is time to further rethink fusion energy's development strategy. Specifically, as was suggested by Grant Logan and Dale Meade, and in keeping with the restructuring of 1996, a theme of better, cheaper, faster fusion would serve the program more effectively than ''demonstrating controlled ignition...and integrated testing of the high-heat-flux and nuclear components required to utilize fusion energy...'' which are the important ingredients of ITER's objectives. The author has personally shifted his view for a mixture of technical and political reasons. On the technical side, he senses that through advanced tokamak research, spherical tokamak research, and advanced stellarator work, scientists are coming to a new understanding that might make a burning-plasma device significantly smaller and less expensive. Thus waiting for a few years, even ten years, seems prudent. Scientifically, there is fascinating physics to be learned through studies of burning plasma on a tokamak. And clearly if one wishes to study burning plasma physics in a sustained plasma, there is no other configuration with an adequate database on which to proceed. But what is the urgency of moving towards an ITER-like step focused on burning plasma? Some of the arguments put forward and the counter arguments are discussed here

  7. Com quantos paus se faz uma canoa?

    Directory of Open Access Journals (Sweden)

    Mariângela Andrade Paraizo

    1996-10-01

    Full Text Available Neste texto, pretendo trabalhar com o conto /tA terceira margem do rio", no contexto do livro Primeiras Estórias, de João Guimarães Rosa, confrontando-o com ofilme de Nelson Pereira dos Santos e a música de Milton Nascimento e Caetano Veloso, ambos com o mesmo nome. Os três trabalhos nos mostram o efeito de repetição no processo narrativo.

  8. A time to pause and ponder

    DEFF Research Database (Denmark)

    Daugbjerg, Peer; Spencer, Christopher

    @bolton.ac.uk) will build on his work with teacher educators, self-reflection as professional development and practice (Spencer, 2015). This study considers how to maintain and continue to develop professional skills and knowledge, where teacher educators systematically reflect on among other things...... Thyself: Self-Reflection and Judgement of the Teachers of Teachers” (presentation to the ‘Reflective Learning and Teaching for Thinking’ TIG @ ETEN 2015 http://www.jeten-online.org/index.php/jeten/article/view/91/116...

  9. Menafsir Dekonstruksi Derida dalam Sosok Paus Fransiskus

    Directory of Open Access Journals (Sweden)

    Frederikus Fios

    2014-10-01

    Full Text Available Jacques Derida is a phenomenal philosopher through his philosophy of deconstruction theory. Derida showed systematically the death of structuralism. His speech shocked the world of academics in France and almost all of America and Europe. Deconstruction is a new way of reading the text, by shifting the core of a text to the side, and put the idea on the edge (the unnoticed, hidden ideas to the center or importance. Derida rejected dichotomous, binary opposition, bipolarity, thinking model or ways of thinking that one is privileging and marginalizing other ideas. Derida thought the model that would proclaim democratic, open, and dynamic diversity that would make room for multiple interpretations of meaning or open horizon that tolerate differences in interpretation of a text. What was conceptualized by Derida is found legitimacy in practical adequacy in the figure of Pope Francis, the Catholic Church's highest leader. Francis shows a deconstructive way to lead contemporary Catholic Church. Francis has opened a new, broader, and other meaning in looking the praxis of the Church. He does not prioritize elitist lifestyle, yet puts a simple and frugal lifestyle. He changes conservative theology into progressive-liberal theology. He realized Church needs not theology but a living testimony of a good, caring, generous, compassion life that does not use religion for immoral behavior, dehumanization, and corruption. Derida did philosophical deconstruction, Francis did spiritual-leadership deconstruction. What unites both of them is a word called "deconstruction".  

  10. A Pause in the Impatience of Things

    DEFF Research Database (Denmark)

    du Gay, Paul

    2017-01-01

    This chapter argues that “speed,” or lack thereof, lies at the heart of much that has been written about bureaucracy generally, and about Max Weber’s theory of bureaucracy in particular. On the one hand, within sociology and social theory, Weber is regarded as one of the chief critics of bureaucr...

  11. A Time to Pause and Ponder

    DEFF Research Database (Denmark)

    Daugbjerg, Peer; Spencer, Christopher

    2018-01-01

    In this paper the authors share experiences from teacher education in the UK and Denmark. They apply methodologies for supporting teacher students from initial exposure to the classroom setting, through training programmes and into the early stages of their professional work. They use Frankl...

  12. Evidence that yeast SGS1, DNA2, SRS2, and FOB1 interact to maintain rDNA stability

    International Nuclear Information System (INIS)

    Tao Weitao; Budd, Martin; Campbell, Judith L.

    2003-01-01

    We and others have proposed that faulty processing of arrested replication forks leads to increases in recombination and chromosome instability in Saccharomyces cerevisiae. Now we use the ribosomal DNA locus, which is a good model for all stages of DNA replication, to test this hypothesis. We showed previously that DNA replication pausing at the ribosomal DNA replication fork barrier (RFB) is accompanied by the occurrence of double-strand breaks near the RFB. Both pausing and breakage are elevated in the hypomorphic dna2-2 helicase mutant. Deletion of FOB1 suppresses the elevated pausing and DSB formation. Our current work shows that mutation inactivating Sgs1, the yeast RecQ helicase ortholog, also causes accumulation of stalled replication forks and DSBs at the rDNA RFB. Either deletion of FOB1, which suppresses fork blocking and certain types of rDNA recombination, or an increase in SIR2 gene dosage, which suppresses rDNA recombination, reduces the number of forks persisting at the RFB. Although dna2-2 sgs1Δ double mutants are conditionally lethal, they do not show enhanced rDNA defects compared to sgs1Δ alone. However, surprisingly, the dna2-2 sgs1Δ lethality is suppressed by deletion of FOB1. On the other hand, the dna2-2 sgs1Δ lethality is only partially suppressed by deletion of rad51Δ. We propose that the replication-associated defects that we document in the rDNA are characteristic of similar events occurring either stochastically throughout the genome or at other regions where replication forks move slowly or stall, such as telomeres, centromeres, or replication slow zones

  13. Evidence that yeast SGS1, DNA2, SRS2, and FOB1 interact to maintain rDNA stability

    Energy Technology Data Exchange (ETDEWEB)

    Tao Weitao; Budd, Martin; Campbell, Judith L

    2003-11-27

    We and others have proposed that faulty processing of arrested replication forks leads to increases in recombination and chromosome instability in Saccharomyces cerevisiae. Now we use the ribosomal DNA locus, which is a good model for all stages of DNA replication, to test this hypothesis. We showed previously that DNA replication pausing at the ribosomal DNA replication fork barrier (RFB) is accompanied by the occurrence of double-strand breaks near the RFB. Both pausing and breakage are elevated in the hypomorphic dna2-2 helicase mutant. Deletion of FOB1 suppresses the elevated pausing and DSB formation. Our current work shows that mutation inactivating Sgs1, the yeast RecQ helicase ortholog, also causes accumulation of stalled replication forks and DSBs at the rDNA RFB. Either deletion of FOB1, which suppresses fork blocking and certain types of rDNA recombination, or an increase in SIR2 gene dosage, which suppresses rDNA recombination, reduces the number of forks persisting at the RFB. Although dna2-2 sgs1{delta} double mutants are conditionally lethal, they do not show enhanced rDNA defects compared to sgs1{delta} alone. However, surprisingly, the dna2-2 sgs1{delta} lethality is suppressed by deletion of FOB1. On the other hand, the dna2-2 sgs1{delta} lethality is only partially suppressed by deletion of rad51{delta}. We propose that the replication-associated defects that we document in the rDNA are characteristic of similar events occurring either stochastically throughout the genome or at other regions where replication forks move slowly or stall, such as telomeres, centromeres, or replication slow zones.

  14. Grain size dependent optical band gap of CdI2 films

    Indian Academy of Sciences (India)

    Unknown

    absorption data near band edge can be fitted to an indirect band gap of 3 eV. The dependence of band gap ... while to carry out the optical studies on CdI2 films in order to .... replotted as (αhν)1/2 vs hν to determine indirect gap as shown in the ...

  15. Monaural and binaural response properties of neurons in the inferior colliculus of the rabbit: effects of sodium pentobarbital.

    Science.gov (United States)

    Kuwada, S; Batra, R; Stanford, T R

    1989-02-01

    1. We studied the effects of sodium pentobarbital on 22 neurons in the inferior colliculus (IC) of the rabbit. We recorded changes in the sensitivity of these neurons to monaural stimulation and to ongoing interaural time differences (ITDs). Monaural stimuli were tone bursts at or near the neuron's best frequency. The ITD was varied by delivering tones that differed by 1 Hz to the two ears, resulting in a 1-Hz binaural beat. 2. We assessed a neuron's ITD sensitivity by calculating three measures from the responses to binaural beats: composite delay, characteristic delay (CD), and characteristic phase (CP). To obtain the composite delay, we first derived period histograms by averaging, showing the response at each stimulating frequency over one period of the beat frequency. Second, the period histograms were replotted as a function of their equivalent interaural delay and then averaged together to yield the composite delay curve. Last, we calculated the composite peak or trough delay by fitting a parabola to the peak or trough of this composite curve. The composite delay curve represents the average response to all frequencies within the neuron's responsive range, and the peak reflects the interaural delay that produces the maximum response. The CD and CP were estimated from a weighted fit of a regression line to the plot of the mean interaural phase of the response versus the stimulating frequency. The slope and phase intercept of this regression line yielded estimates of CD and CP, respectively. These two quantities are thought to reflect the mechanism of ITD sensitivity, which involves the convergence of phase-locked inputs on a binaural cell. The CD estimates the difference in the time required for the two inputs to travel from either ear to this cell, whereas the CP reflects the interaural phase difference of the inputs at this cell. 3. Injections of sodium pentobarbital at subsurgical dosages (less than 25 mg/kg) almost invariably altered the neuron's response

  16. 15 YEARS ON AND TIME FOR A REFLECTIVE PAUSE?

    African Journals Online (AJOL)

    EEASA turned 15 years old in 1997 - not an unim- portant event in the life of a voluntary association. Its activities have exceeded many of the dreams of its founders and it has much to be proud of. Nevertheless, with growing environmental education linkages between the countries of sub-saharan. Afuca, a major new ...

  17. World natural gas supply and demand: Brief pause in production

    International Nuclear Information System (INIS)

    Coccia, G.

    1993-01-01

    With reference to the 1992 CEDIGAZ (Centre International sur le Gas Naturel et tous Hydrocarbures Gazeux) report on world natural gas supply and demand, this paper assesses current market and production trends in this industry. The slight drop in production in 1992, the first which has which has occurred after many consecutive years of steady increases, is ascribed to ownership disputes among the former-USSR republics and major changes in the organizational structure of the former-USSR's natural gas industry. Strong increases in demand are forecasted due to expected strong population growth and increased industrialization to take place in China and India. Price trends in natural gas should remain steady as a result of plentiful supplies of this fuel and coal, a major competitor. The use of relatively clean natural gas is suggested as a practical alternative to energy taxes now being proposed as a means for the reduction of greenhouse gas emissions

  18. Pause med trombocytaggregationshaemmere hos kirurgiske patienter med kardiel stent

    DEFF Research Database (Denmark)

    Johansen, Mathias; Afshari, Arash; Kristensen, Billy

    2010-01-01

    Dual antiplatelet therapy with aspirin and clopidogrel is increasingly used for secondary prevention of cardiovascular events in patients with percutaneous coronary intervention. Anesthesiologists and surgeons are faced with the challenge of managing these patients prior to a surgical procedure...

  19. Pause med trombocytaggregationshaemmere hos kirurgiske patienter med kardiel stent

    DEFF Research Database (Denmark)

    Johansen, Mathias; Afshari, Arash; Kristensen, Billy

    2010-01-01

    Dual antiplatelet therapy with aspirin and clopidogrel is increasingly used for secondary prevention of cardiovascular events in patients with percutaneous coronary intervention. Anesthesiologists and surgeons are faced with the challenge of managing these patients prior to a surgical procedure. ....... Premature discontinuation of antiplatelet therapy constitutes a substantial risk of stent thrombosis, myocardial infarction and death. Continuing therapy increases the risk of bleeding. We provide the latest evidence on this topic for patients awaiting non-cardiac surgery....

  20. CERN Council pauses for effect (LHC approval a step nearer)

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    Aweek of intense diplomatic activity which had high level telephones ringing across Europe culminated in an imaginative and unexpected move on 24 June, when delegates adjourned the 100th session of CERN's governing body, Council, to be reconvened at a later date. On the Council table was the vote for CERN's next major machine, now universally agreed as the world focus of particle physics research for the start of the 21st century, the LHC proton-proton collider, to be built in CERN's 27-kilometre LEP tunnel, and the largest and most complex scientific joint effort ever undertaken in Europe

  1. Ready, Steady … Pause: Integrating ICT into Shanghai Preschools

    Science.gov (United States)

    Dong, Chuanmei; Newman, Linda

    2016-01-01

    Western research over the last decade has shown that early childhood (EC) teachers' perspectives on the role of Information and Communication Technologies (ICT) in the early years strongly shape young children's experiences in educational settings and affect the integration of ICT into the classroom. The research in China is scant however. This…

  2. CHD1 regulates cell fate determination by activation of differentiation-induced genes

    DEFF Research Database (Denmark)

    Baumgart, Simon J; Najafova, Zeynab; Hossan, Tareq

    2017-01-01

    The coordinated temporal and spatial activation of gene expression is essential for proper stem cell differentiation. The Chromodomain Helicase DNA-binding protein 1 (CHD1) is a chromatin remodeler closely associated with transcription and nucleosome turnover downstream of the transcriptional start...... site (TSS). In this study, we show that CHD1 is required for the induction of osteoblast-specific gene expression, extracellular-matrix mineralization and ectopic bone formation in vivo. Genome-wide occupancy analyses revealed increased CHD1 occupancy around the TSS of differentiation-activated genes....... Furthermore, we observed that CHD1-dependent genes are mainly induced during osteoblast differentiation and are characterized by higher levels of CHD1 occupancy around the TSS. Interestingly, CHD1 depletion resulted in increased pausing of RNA Polymerase II (RNAPII) and decreased H2A.Z occupancy close...

  3. Single-Molecule Analysis of the Rotation of F1-ATPase under High Hydrostatic Pressure

    Science.gov (United States)

    Okuno, Daichi; Nishiyama, Masayoshi; Noji, Hiroyuki

    2013-01-01

    F1-ATPase is the water-soluble part of ATP synthase and is an ATP-driven rotary molecular motor that rotates the rotary shaft against the surrounding stator ring, hydrolyzing ATP. Although the mechanochemical coupling mechanism of F1-ATPase has been well studied, the molecular details of individual reaction steps remain unclear. In this study, we conducted a single-molecule rotation assay of F1 from thermophilic bacteria under various pressures from 0.1 to 140 MPa. Even at 140 MPa, F1 actively rotated with regular 120° steps in a counterclockwise direction, showing high conformational stability and retention of native properties. Rotational torque was also not affected. However, high hydrostatic pressure induced a distinct intervening pause at the ATP-binding angles during continuous rotation. The pause was observed under both ATP-limiting and ATP-saturating conditions, suggesting that F1 has two pressure-sensitive reactions, one of which is evidently ATP binding. The rotation assay using a mutant F1(βE190D) suggested that the other pressure-sensitive reaction occurs at the same angle at which ATP binding occurs. The activation volumes were determined from the pressure dependence of the rate constants to be +100 Å3 and +88 Å3 for ATP binding and the other pressure-sensitive reaction, respectively. These results are discussed in relation to recent single-molecule studies of F1 and pressure-induced protein unfolding. PMID:24094404

  4. Is rapid automatized naming related to reading and mathematics for the same reason(s)? A follow-up study from kindergarten to Grade 1.

    Science.gov (United States)

    Georgiou, George K; Tziraki, Niki; Manolitsis, George; Fella, Argyro

    2013-07-01

    We examined (a) what rapid automatized naming (RAN) components (articulation time and/or pause time) predict reading and mathematics ability and (b) what processing skills involved in RAN (speed of processing, response inhibition, working memory, and/or phonological awareness) may explain its relationship with reading and mathematics. A sample of 72 children were followed from the beginning of kindergarten until the end of Grade 1 and were assessed on measures of RAN, general cognitive ability, speed of processing, attention, working memory, phonological awareness, reading, and mathematics. The results indicated that pause time was the critical component in both the RAN-reading and RAN-mathematics relationships and that it shared most of its predictive variance in reading and mathematics with speed of processing and working memory. Our findings further suggested that, unlike the relationship between RAN and reading fluency in Grade 1, there is nothing in the RAN task that is uniquely related to math. Copyright © 2013 Elsevier Inc. All rights reserved.

  5. A Function for the hnRNP A1/A2 Proteins in Transcription Elongation.

    Science.gov (United States)

    Lemieux, Bruno; Blanchette, Marco; Monette, Anne; Mouland, Andrew J; Wellinger, Raymund J; Chabot, Benoit

    2015-01-01

    The hnRNP A1 and A2 proteins regulate processes such as alternative pre-mRNA splicing and mRNA stability. Here, we report that a reduction in the levels of hnRNP A1 and A2 by RNA interference or their cytoplasmic retention by osmotic stress drastically increases the transcription of a reporter gene. Based on previous work, we propose that this effect may be linked to a decrease in the activity of the transcription elongation factor P-TEFb. Consistent with this hypothesis, the transcription of the reporter gene was stimulated when the catalytic component of P-TEFb, CDK9, was inhibited with DRB. While low levels of A1/A2 stimulated the association of RNA polymerase II with the reporter gene, they also increased the association of CDK9 with the repressor 7SK RNA, and compromised the recovery of promoter-distal transcription on the Kitlg gene after the release of pausing. Transcriptome analysis revealed that more than 50% of the genes whose expression was affected by the siRNA-mediated depletion of A1/A2 were also affected by DRB. RNA polymerase II-chromatin immunoprecipitation assays on DRB-treated and A1/A2-depleted cells identified a common set of repressed genes displaying increased occupancy of polymerases at promoter-proximal locations, consistent with pausing. Overall, our results suggest that lowering the levels of hnRNP A1/A2 elicits defective transcription elongation on a fraction of P-TEFb-dependent genes, hence favoring the transcription of P-TEFb-independent genes.

  6. A Function for the hnRNP A1/A2 Proteins in Transcription Elongation.

    Directory of Open Access Journals (Sweden)

    Bruno Lemieux

    Full Text Available The hnRNP A1 and A2 proteins regulate processes such as alternative pre-mRNA splicing and mRNA stability. Here, we report that a reduction in the levels of hnRNP A1 and A2 by RNA interference or their cytoplasmic retention by osmotic stress drastically increases the transcription of a reporter gene. Based on previous work, we propose that this effect may be linked to a decrease in the activity of the transcription elongation factor P-TEFb. Consistent with this hypothesis, the transcription of the reporter gene was stimulated when the catalytic component of P-TEFb, CDK9, was inhibited with DRB. While low levels of A1/A2 stimulated the association of RNA polymerase II with the reporter gene, they also increased the association of CDK9 with the repressor 7SK RNA, and compromised the recovery of promoter-distal transcription on the Kitlg gene after the release of pausing. Transcriptome analysis revealed that more than 50% of the genes whose expression was affected by the siRNA-mediated depletion of A1/A2 were also affected by DRB. RNA polymerase II-chromatin immunoprecipitation assays on DRB-treated and A1/A2-depleted cells identified a common set of repressed genes displaying increased occupancy of polymerases at promoter-proximal locations, consistent with pausing. Overall, our results suggest that lowering the levels of hnRNP A1/A2 elicits defective transcription elongation on a fraction of P-TEFb-dependent genes, hence favoring the transcription of P-TEFb-independent genes.

  7. Breathing response of the tegu lizard to 1-4% CO2 in the mouth and nose or inspired into the lungs.

    Science.gov (United States)

    Ballam, G O

    1985-12-01

    This study investigated the influence on ventilation of elevated CO2 in the nasal and buccal cavities (NaBuCO2) vs the effect of elevated CO2 levels inspired into the lungs (LuCO2). Separate gas sources were used to independently alter NaBuCO2 and LuCO2. As little as 1% NaBuCO2 or LuCO2 significantly increased the pause duration between the active expiratory-inspiratory cycles. Elevated NaBuCO2 caused minor changes in tidal volume, mean inspiratory and expiratory flow, and inspiratory and expiratory durations with a significant reduction in total ventilation. Elevated LuCO2 had little effect on inspiratory or expiratory durations but unlike CO2 in the upper airways, significantly increased tidal volume and mean inspiratory and expiratory flows. This study demonstrates that the increased pause duration seen in the tegu lizard to elevated environmental CO2 is due to a receptor response in the buccal or nasal cavities and also to elevated CO2 concentrations inspired into the lungs. Sensitivity of the ventilatory responses to CO2 in the upper airways is well within a physiologically relevant range.

  8. Ire1 mediated mRNA splicing in a C-terminus deletion mutant of Drosophila Xbp1.

    Directory of Open Access Journals (Sweden)

    Dina S Coelho

    Full Text Available The Unfolded Protein Response is a homeostatic mechanism that permits eukaryotic cells to cope with Endoplasmic Reticulum (ER stress caused by excessive accumulation of misfolded proteins in the ER lumen. The more conserved branch of the UPR relies on an ER transmembrane enzyme, Ire1, which, upon ER stress, promotes the unconventional splicing of a small intron from the mRNA encoding the transcription factor Xbp1. In mammals, two specific regions (the hydrophobic region 2--HR2--and the C-terminal translational pausing site present in the Xbp1unspliced protein mediate the recruitment of the Xbp1 mRNA-ribosome-nascent chain complex to the ER membrane, so that Xbp1 mRNA can be spliced by Ire1. Here, we generated a Drosophila Xbp1 deletion mutant (Excision101 lacking both HR2 and C-terminal region, but not the Ire1 splicing site. We show that Ire1-dependent splicing of Xbp1 mRNA is reduced, but not abolished in Excision101. Our results suggest the existence of additional mechanisms for ER membrane targeting of Xbp1 mRNA that are independent of the C-terminal domain of Drosophila Xbp1unspliced.

  9. The 1 × 1 m hypersonic wind tunnel Kochel/Tullahoma 1940-1960

    Science.gov (United States)

    Eckardt, Dietrich

    2015-03-01

    Peenemünde and Cape Canaveral mark cornerstones of space history. Kochel in Southern Germany and Tullahoma in Tennessee, USA also belong in this category. The technically unique Kochel wind tunnel was part of the German long-distance missile development strategy, planned and prepared in secret before the beginning of World War II. A 57 MW closed-circuit wind tunnel facility with 1 × 1 m measuring section was planned for continuous-flow simulation at high Mach numbers Ma 7-10. In the early 1940 s a site beside the Walchensee Power Station at Kochel am See in Upper Bavaria, Germany was chosen to provide the required altitude difference of 200 m for the hydraulic turbine drives. The preparatory activities for the erection of this impressive hypersonic wind tunnel facility were pushed ahead until an enforced temporary pause in September 1944. In early May 1945 US troops occupied the area and, in due course, scientists of General Arnold's Scientific Advisory Group, the `von Kármán team', ordered the transfer to the USA of available equipment, design materials and other paperwork. Here, at the Arnold Engineering Development Center (AEDC) Tullahoma, TN this `Tunnel A' was built to begin operation around 1957. The testing was conducted on the Mach 7 experimental aircraft X-15, space shuttle developments and still secret investigations on unmanned hypersonic vehicles.

  10. LabVIEW Task Manager v. 1.10.0

    Energy Technology Data Exchange (ETDEWEB)

    2016-12-21

    LabVIEW Task Manager is a debugging tool for use during code development in the National Instruments (NI) LabVIEW® IDE. While providing a dynamic & big-picture view of running code, an expandable/collapsible tree diagram displays detailed information (both static and dynamic) on all VIs in memory, belonging to a selected project/target. It allows for interacting with single or multiple selected VIs at a time, providing significant benefits while troubleshooting, and has the following features: Look & Feel similar to Windows® Task Manager; Selection of project/target; Lists all VIs in memory, grouped by class/library; Searches for and enumerates clones in memory; DropIn VI for including dynamically referenced clones (Clone Beacon); 'Refresh Now' (F5) re-reads all VIs in memory and adds new ones to the tree; Displays VI name, owning class/library, state, path, data size & code size; Displays VI FP Behavior, Reentrant?, Reentrancy Type, Paused? & Highlight?; Sort by any column, including by library name; Filter by item types vi, ctl, and vit/ctt; Filter out vi.lib and global VIs; Tracking of, and ability to toggle, execution highlighting on multiple selected VIs; Tracking of paused VIs with ability to Pause/Resume/TogglePause multiple selected VIs; DropIn VI for pausing on a condition; If a clone initiates a pause, a different pause symbol is used for all clones of that same reentrant original VI; Select multiple VIs and open or close their FPs or BDs; Double Click a VI from the tree to bring the BD (first choice) or FP to front, if already open; and Select multiple top-level VIs and Abort them.

  11. Sick sinus syndrome in HCN1-deficient mice.

    Science.gov (United States)

    Fenske, Stefanie; Krause, Stefanie C; Hassan, Sami I H; Becirovic, Elvir; Auer, Franziska; Bernard, Rebekka; Kupatt, Christian; Lange, Philipp; Ziegler, Tilman; Wotjak, Carsten T; Zhang, Henggui; Hammelmann, Verena; Paparizos, Christos; Biel, Martin; Wahl-Schott, Christian A

    2013-12-17

    Sinus node dysfunction (SND) is a major clinically relevant disease that is associated with sudden cardiac death and requires surgical implantation of electric pacemaker devices. Frequently, SND occurs in heart failure and hypertension, conditions that lead to electric instability of the heart. Although the pathologies of acquired SND have been studied extensively, little is known about the molecular and cellular mechanisms that cause congenital SND. Here, we show that the HCN1 protein is highly expressed in the sinoatrial node and is colocalized with HCN4, the main sinoatrial pacemaker channel isoform. To characterize the cardiac phenotype of HCN1-deficient mice, a detailed functional characterization of pacemaker mechanisms in single isolated sinoatrial node cells, explanted beating sinoatrial node preparation, telemetric in vivo electrocardiography, echocardiography, and in vivo electrophysiology was performed. On the basis of these experiments we demonstrate that mice lacking the pacemaker channel HCN1 display congenital SND characterized by bradycardia, sinus dysrhythmia, prolonged sinoatrial node recovery time, increased sinoatrial conduction time, and recurrent sinus pauses. As a consequence of SND, HCN1-deficient mice display a severely reduced cardiac output. We propose that HCN1 stabilizes the leading pacemaker region within the sinoatrial node and hence is crucial for stable heart rate and regular beat-to-beat variation. Furthermore, we suggest that HCN1-deficient mice may be a valuable genetic disease model for human SND.

  12. 1 GR PHOLOGIC L N LYSIS OF EDITORI L LE D P R GR PHS OF ...

    African Journals Online (AJOL)

    Tracie1

    defines language as the expression and communication of emotions or ideas between human beings by means of speech and hearing, the sounds ... we speak, we make use of pauses of tone, gestures and facial expression but when we ...

  13. Enrichment of HP1a on Drosophila chromosome 4 genes creates an alternate chromatin structure critical for regulation in this heterochromatic domain.

    Directory of Open Access Journals (Sweden)

    Nicole C Riddle

    2012-09-01

    Full Text Available Chromatin environments differ greatly within a eukaryotic genome, depending on expression state, chromosomal location, and nuclear position. In genomic regions characterized by high repeat content and high gene density, chromatin structure must silence transposable elements but permit expression of embedded genes. We have investigated one such region, chromosome 4 of Drosophila melanogaster. Using chromatin-immunoprecipitation followed by microarray (ChIP-chip analysis, we examined enrichment patterns of 20 histone modifications and 25 chromosomal proteins in S2 and BG3 cells, as well as the changes in several marks resulting from mutations in key proteins. Active genes on chromosome 4 are distinct from those in euchromatin or pericentric heterochromatin: while there is a depletion of silencing marks at the transcription start sites (TSSs, HP1a and H3K9me3, but not H3K9me2, are enriched strongly over gene bodies. Intriguingly, genes on chromosome 4 are less frequently associated with paused polymerase. However, when the chromatin is altered by depleting HP1a or POF, the RNA pol II enrichment patterns of many chromosome 4 genes shift, showing a significant decrease over gene bodies but not at TSSs, accompanied by lower expression of those genes. Chromosome 4 genes have a low incidence of TRL/GAGA factor binding sites and a low T(m downstream of the TSS, characteristics that could contribute to a low incidence of RNA polymerase pausing. Our data also indicate that EGG and POF jointly regulate H3K9 methylation and promote HP1a binding over gene bodies, while HP1a targeting and H3K9 methylation are maintained at the repeats by an independent mechanism. The HP1a-enriched, POF-associated chromatin structure over the gene bodies may represent one type of adaptation for genes embedded in repetitive DNA.

  14. Feasibility and safety of adenosine cardiovascular magnetic resonance in patients with MR conditional pacemaker systems at 1.5 Tesla.

    Science.gov (United States)

    Klein-Wiele, Oliver; Garmer, Marietta; Urbien, Rhyan; Busch, Martin; Kara, Kaffer; Mateiescu, Serban; Grönemeyer, Dietrich; Schulte-Hermes, Michael; Garbrecht, Marc; Hailer, Birgit

    2015-12-22

    Cardiovascular Magnetic Resonance (CMR) with adenosine stress is a valuable diagnostic tool in coronary artery disease (CAD). However, despite the development of MR conditional pacemakers CMR is not yet established in clinical routine for pacemaker patients with known or suspected CAD. A possible reason is that adenosine stress perfusion for ischemia detection in CMR has not been studied in patients with cardiac conduction disease requiring pacemaker therapy. Other than under resting conditions it is unclear whether MR safe pacing modes (paused pacing or asynchronous mode) can be applied safely because the effect of adenosine on heart rate is not precisely known in this entity of patients. We investigate for the first time feasibility and safety of adenosine stress CMR in pacemaker patients in clinical routine and evaluate a pacing protocol that considers heart rate changes under adenosine. We retrospectively analyzed CMR scans of 24 consecutive patients with MR conditional pacemakers (mean age 72.1 ± 11.0 years) who underwent CMR in clinical routine for the evaluation of known or suspected CAD. MR protocol included cine imaging, adenosine stress perfusion and late gadolinium enhancement. Pacemaker indications were sinus node dysfunction (n = 18) and second or third degree AV block (n = 6). Under a pacing protocol intended to avoid competitive pacing on the one hand and bradycardia due to AV block on the other no arrhythmia occurred. Pacemaker stimulation was paused to prevent competitive pacing in sinus node dysfunction with resting heart rate >45 bpm. Sympatho-excitatory effect of adenosine led to a significant acceleration of heart rate by 12.3 ± 8.3 bpm (p pacemakers. Heart rate response to adenosine has to be considered for the choice of pacing modes during CMR.

  15. CHD1 regulates cell fate determination by activation of differentiation-induced genes.

    Science.gov (United States)

    Baumgart, Simon J; Najafova, Zeynab; Hossan, Tareq; Xie, Wanhua; Nagarajan, Sankari; Kari, Vijayalakshmi; Ditzel, Nicholas; Kassem, Moustapha; Johnsen, Steven A

    2017-07-27

    The coordinated temporal and spatial activation of gene expression is essential for proper stem cell differentiation. The Chromodomain Helicase DNA-binding protein 1 (CHD1) is a chromatin remodeler closely associated with transcription and nucleosome turnover downstream of the transcriptional start site (TSS). In this study, we show that CHD1 is required for the induction of osteoblast-specific gene expression, extracellular-matrix mineralization and ectopic bone formation in vivo. Genome-wide occupancy analyses revealed increased CHD1 occupancy around the TSS of differentiation-activated genes. Furthermore, we observed that CHD1-dependent genes are mainly induced during osteoblast differentiation and are characterized by higher levels of CHD1 occupancy around the TSS. Interestingly, CHD1 depletion resulted in increased pausing of RNA Polymerase II (RNAPII) and decreased H2A.Z occupancy close to the TSS, but not at enhancer regions. These findings reveal a novel role for CHD1 during osteoblast differentiation and provide further insights into the intricacies of epigenetic regulatory mechanisms controlling cell fate determination. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  16. MDV-1 variant of Qβ RNA. Final report

    International Nuclear Information System (INIS)

    Gordon, M.P.

    1981-01-01

    MDV-1 is a variant of Qβ RNA which consists of complementary plus (+) and minus (-) strands. The sequences of these strands are well established. MDV-1 is an active template in replication reactions. High-resolution polyacrylamide gel electrophoresis was used to locate sites of replication inhibition in the molecule induced by irradiation of (+) and (-) MDV-1 RNA templates with 254 nanometer (uv) light at a dose of 2500 Jm -2 . Presumably, this inhibition was caused by uridine hydrates and pyrimidine cyclobutane dimers. Each of the ten inhibition sites identified corresponds to regions in the template which contain two or more pyrimidines. Dose-response studies showed that the uv-induced inactivation of the template activity of MDV-1 RNA closely paralleled the formation of uridine hydrates when replication occurred at 12 0 C. At higher temperatures, the template activity of MDV-1 appeared to be less sensitive to uv light. Since pre-incubation of irradiated MDV-1 at 37 0 for 35 min did not affect replication inhibition at 12 0 C, inhibition of replication at 37 0 C does not appear to be due to dehydration of uridine hydrate at the higher temperature. Pauses in nucleic acid synthesis, attributed to kinetic modulators, were observed in a number of systems and were proposed to play a role in the regulation of nucleic acid synthesis. The results reported here suggest that some photolesions might mimic such modulators. The replication of (+) MDV-1 RNA was also inhibited at specific sites by kethoxal, semicarbazide, and methoxyamine. These sites were near some of the sites at which uv-induced replication inhibition occurred. These results suggested that some regions of the (+) MDV-1 molecule are structurally exposed to modification by uv and base-specific chemicals, and were consistent with some features of a computer-generated model of the secondary structure of (+) MDV-1 RNA

  17. The Aversive Agent Lithium Chloride Suppresses Phasic Dopamine Release Through Central GLP-1 Receptors.

    Science.gov (United States)

    Fortin, Samantha M; Chartoff, Elena H; Roitman, Mitchell F

    2016-02-01

    Unconditioned rewarding stimuli evoke phasic increases in dopamine concentration in the nucleus accumbens (NAc) while discrete aversive stimuli elicit pauses in dopamine neuron firing and reductions in NAc dopamine concentration. The unconditioned effects of more prolonged aversive states on dopamine release dynamics are not well understood and are investigated here using the malaise-inducing agent lithium chloride (LiCl). We used fast-scan cyclic voltammetry to measure phasic increases in NAc dopamine resulting from electrical stimulation of dopamine cell bodies in the ventral tegmental area (VTA). Systemic LiCl injection reduced electrically evoked dopamine release in the NAc of both anesthetized and awake rats. As some behavioral effects of LiCl appear to be mediated through glucagon-like peptide-1 receptor (GLP-1R) activation, we hypothesized that the suppression of phasic dopamine by LiCl is GLP-1R dependent. Indeed, peripheral pretreatment with the GLP-1R antagonist exendin-9 (Ex-9) potently attenuated the LiCl-induced suppression of dopamine. Pretreatment with Ex-9 did not, however, affect the suppression of phasic dopamine release by the kappa-opioid receptor agonist, salvinorin A, supporting a selective effect of GLP-1R stimulation in LiCl-induced dopamine suppression. By delivering Ex-9 to either the lateral or fourth ventricle, we highlight a population of central GLP-1 receptors rostral to the hindbrain that are involved in the LiCl-mediated suppression of NAc dopamine release.

  18. The impact of language co-activation on L1 and L2 speech fluency.

    Science.gov (United States)

    Bergmann, Christopher; Sprenger, Simone A; Schmid, Monika S

    2015-10-01

    Fluent speech depends on the availability of well-established linguistic knowledge and routines for speech planning and articulation. A lack of speech fluency in late second-language (L2) learners may point to a deficiency of these representations, due to incomplete acquisition. Experiments on bilingual language processing have shown, however, that there are strong reasons to believe that multilingual speakers experience co-activation of the languages they speak. We have studied to what degree language co-activation affects fluency in the speech of bilinguals, comparing a monolingual German control group with two bilingual groups: 1) first-language (L1) attriters, who have fully acquired German before emigrating to an L2 English environment, and 2) immersed L2 learners of German (L1: English). We have analysed the temporal fluency and the incidence of disfluency markers (pauses, repetitions and self-corrections) in spontaneous film retellings. Our findings show that learners to speak more slowly than controls and attriters. Also, on each count, the speech of at least one of the bilingual groups contains more disfluency markers than the retellings of the control group. Generally speaking, both bilingual groups-learners and attriters-are equally (dis)fluent and significantly more disfluent than the monolingual speakers. Given that the L1 attriters are unaffected by incomplete acquisition, we interpret these findings as evidence for language competition during speech production. Copyright © 2015. Published by Elsevier B.V.

  19. Blinks, saccades, and fixation pauses during vigilance task performance. II., Gender and time of day.

    Science.gov (United States)

    1996-03-01

    As operators are required to spend more time monitoring computer controlled devices in future systems, it is critical to define the task and situational factors (i.e., fatigue) that may impact vigilance and performance. Aspects of the gaze system can...

  20. A time to pause and ponder - will to meaning in education

    DEFF Research Database (Denmark)

    Daugbjerg, Peer; Spencer, Christopher

    Worries about the effect of trade and globalisation on the workforce are “a staple of politics in the US and Europe” (Financial Times 2016). There would appear to be a general global movement towards isolation and protectionism (see Brexit, Trump, Putin). Europa was the battle field for conflicts...

  1. Acute ischemic heart disease and interventional cardiology: a time for pause

    Directory of Open Access Journals (Sweden)

    Brophy James M

    2006-10-01

    Full Text Available Abstract Background A major change has occurred in the last few years in the therapeutic approach to patients presenting with all forms of acute coronary syndromes. Whether or not these patients present initially to tertiary cardiac care centers, they are now routinely referred for early coronary angiography and increasingly undergo percutaneous revascularization. This practice is driven primarily by the angiographic image and technical feasibility. Concomitantly, there has been a decline in expectant or ischemia-guided medical management based on specific clinical presentation, response to initial treatment, and results of noninvasive stratification. This 'tertiarization' of acute coronary care has been fuelled by the increasing sophistication of the cardiac armamentarium, the peer-reviewed publication of clinical studies purporting to show the superiority of invasive cardiac interventions, and predominantly supporting (non-peer-reviewed editorials, newsletters, and opinion pieces. Discussion This review presents another perspective, based on a critical reexamination of the evidence. The topics addressed are: reperfusion treatment of ST-elevation myocardial infarction; the indications for invasive intervention following thrombolysis; the role of invasive management in non-ST-elevation myocardial infarction and unstable angina; and cost-effectiveness and real world considerations. A few cases encountered in recent practice in community and tertiary hospitals are presented for illustrative purposes The numerous and far-reaching scientific, economic, and philosophical implications that are a consequence of this marked change in clinical practice as well as healthcare, decisional and conflict of interest issues are explored. Summary The weight of evidence does not support the contemporary unfocused broad use of invasive interventional procedures across the spectrum of acute coronary clinical presentations. Excessive and unselective recourse to these procedures has deleterious implications for the organization of cardiac health care and undesirable economic, scientific and intellectual consequences. It is suggested that there is need for a new equilibrium based on more refined clinical risk stratification in the treatment of patients who present with acute coronary syndromes.

  2. Role of transcription pausing in the control of the pyrE attenuator in Escherichia coli

    DEFF Research Database (Denmark)

    Andersen, J. T.; Jensen, Kaj Frank; Poulsen, Peter

    1991-01-01

    Expression of the Escherichia coli pyrE gene is regulated by transcription attenuation in the intercistronic orfE–pyrE region and modulated by the distance between the transcribing RNA polymerase and the leading ribosome as a function of the supply of UTP and GTP. In this communication we show...

  3. From brief gaps to very long pauses: temporal isolation does not benefit serial recall.

    Science.gov (United States)

    Nimmo, Lisa M; Lewandowsky, Stephan

    2005-12-01

    Theoretical explanations of short-term memory for serial order can be classified on the basis of whether or not they invoke time as a causal variable. According to time-based accounts, such as temporal distinctiveness theories, there is an intimate link between time and memory. Event-based theories, by contrast, postulate processes such as interference or rehearsal to account for seemingly temporal phenomena in short-term memory. We report an experiment that examined whether extended temporal isolation benefits serial recall performance. Regardless of whether the participants were quiet or performed articulatory suppression during list presentation, temporal isolation did not benefit memory even if items were separated from their neighbors by up to 7 sec. These findings challenge time-based theories of short-term memory.

  4. Victoria Law School Ten Years On—A Time to Pause and Reflect

    Directory of Open Access Journals (Sweden)

    Andrew Clarke

    2013-11-01

    Full Text Available On 4 November 2010, a large and distinguished audience assembled at the Queen Street Campus of Victoria University to celebrate the tenth anniversary of the founding of Victoria Law School. This Foreword records the diverse achievements of Victoria Law School over the past decade.

  5. Victoria Law School Ten Years On—A Time to Pause and Reflect

    OpenAIRE

    Andrew Clarke

    2013-01-01

    On 4 November 2010, a large and distinguished audience assembled at the Queen Street Campus of Victoria University to celebrate the tenth anniversary of the founding of Victoria Law School. This Foreword records the diverse achievements of Victoria Law School over the past decade.

  6. Revising Lecture Notes: How Revision, Pauses, and Partners Affect Note Taking and Achievement

    Science.gov (United States)

    Luo, Linlin; Kiewra, Kenneth A.; Samuelson, Lydia

    2016-01-01

    Note taking has been categorized as a two-stage process: the recording of notes and the review of notes. We contend that note taking might best involve a three-stage process where the missing stage is revision. This study investigated the benefits of revising lecture notes and addressed two questions: First, is revision more effective than…

  7. Tracking the Mind during Writing: Immediacy, Delayed, and Anticipatory Effects on Pauses and Writing Rate

    Science.gov (United States)

    Maggio, Severine; Lete, Bernard; Chenu, Florence; Jisa, Harriet; Fayol, Michel

    2012-01-01

    This study examines the dynamics of cognitive processes during writing. Participants were 5th, 7th and 9th graders ranging in age from 10 to 15 years. They were shown a short silent video composed of clips illustrating conflictual situations between people in school, and were invited to produce a narrative text. Three chronometric measures of word…

  8. Press learning: The potential of podcasting through pause, record, play and stop

    Directory of Open Access Journals (Sweden)

    Tara Brabazon

    2016-09-01

    Full Text Available Podcasts are entering their second decade. However, this article does not present a chronological narrative of this history or focus groups exploring their effectiveness. Instead, this paper probes the enlivening capacity of podcasting when inserted into the much wider discourse of sonic media. My research probes the impact on teaching and learning when cutting away four of our five senses to focus on auditory culture, sonic media, hearing and listening. This research shows the value of ‘blind listening,’ cutting away the eyes and visual literacy, to activate more complex modes of learning.

  9. Introduction to the contributions of the Symposium "Practice Research in Discussion: a pause for reflection"

    NARCIS (Netherlands)

    Dijkum, van C.; Reijmerink, W.; Wagemakers, A.

    2015-01-01

    In 2011, the Amsterdam University of Applied Science (HvA), the Dutch Organization of Methodology in the Social sciences (NOSMO), and the Alumni Circle Adult Education of Amsterdam University (ACA) organized a symposium about practice-oriented research. An onset to this symposium was that

  10. Never Say No... How the Brain Interprets the Pregnant Pause in Conversation.

    Directory of Open Access Journals (Sweden)

    Sara Bögels

    Full Text Available In conversation, negative responses to invitations, requests, offers, and the like are more likely to occur with a delay-conversation analysts talk of them as dispreferred. Here we examine the contrastive cognitive load 'yes' and 'no' responses make, either when relatively fast (300 ms after question offset or delayed (1000 ms. Participants heard short dialogues contrasting in speed and valence of response while having their EEG recorded. We found that a fast 'no' evokes an N400-effect relative to a fast 'yes'; however, this contrast disappeared in the delayed responses. 'No' responses, however, elicited a late frontal positivity both if they were fast and if they were delayed. We interpret these results as follows: a fast 'no' evoked an N400 because an immediate response is expected to be positive--this effect disappears as the response time lengthens because now in ordinary conversation the probability of a 'no' has increased. However, regardless of the latency of response, a 'no' response is associated with a late positivity, since a negative response is always dispreferred. Together these results show that negative responses to social actions exact a higher cognitive load, but especially when least expected, in immediate response.

  11. Speech and Pause Characteristics Associated with Voluntary Rate Reduction in Parkinson's Disease and Multiple Sclerosis

    Science.gov (United States)

    Tjaden, Kris; Wilding, Greg

    2011-01-01

    The primary purpose of this study was to investigate how speakers with Parkinson's disease (PD) and Multiple Sclerosis (MS) accomplish voluntary reductions in speech rate. A group of talkers with no history of neurological disease was included for comparison. This study was motivated by the idea that knowledge of how speakers with dysarthria…

  12. Highly sensitive magneto-motive photoacoustic and ultrasound (PAUS) imaging with cyclic excitations

    International Nuclear Information System (INIS)

    Arnal, B; Wei, C-W; Li, J; Gao, X; O’Donnell, M

    2016-01-01

    Highly specific molecular imaging with photoacoustics (PA) must suppress background endogenous signals while maintaining signals from target nanoagents. Magneto-motive PA was introduced to perform motion-based background suppression using a low frequency magnetic field. Previous studies show suppression based on displacement magnitude can suffer if significant physiological motion is present. This limitation can be overcome using cyclic magneto-motive PA (cmmPA), where multiple cycles of an ac magnetic field are used and the coherence of detected displacements is the retrieved information. In this paper, we show a method to enhance the magnetic response of an electromagnet specifically for cmmPA. Several magnetic frequencies were tested and a simple model is proposed to describe displacement frequency dependence. By choosing optimal parameters based on this model, we show that the technique can detect a low number of tagged cells using either US-based or PA-based displacement estimation. In addition, robustness to physiological motion is demonstrated in a moving phantom. (paper)

  13. Improved Predictions of Drug-Drug Interactions Mediated by Time-Dependent Inhibition of CYP3A.

    Science.gov (United States)

    Yadav, Jaydeep; Korzekwa, Ken; Nagar, Swati

    2018-05-07

    Time-dependent inactivation (TDI) of cytochrome P450s (CYPs) is a leading cause of clinical drug-drug interactions (DDIs). Current methods tend to overpredict DDIs. In this study, a numerical approach was used to model complex CYP3A TDI in human-liver microsomes. The inhibitors evaluated included troleandomycin (TAO), erythromycin (ERY), verapamil (VER), and diltiazem (DTZ) along with the primary metabolites N-demethyl erythromycin (NDE), norverapamil (NV), and N-desmethyl diltiazem (NDD). The complexities incorporated into the models included multiple-binding kinetics, quasi-irreversible inactivation, sequential metabolism, inhibitor depletion, and membrane partitioning. The resulting inactivation parameters were incorporated into static in vitro-in vivo correlation (IVIVC) models to predict clinical DDIs. For 77 clinically observed DDIs, with a hepatic-CYP3A-synthesis-rate constant of 0.000 146 min -1 , the average fold difference between the observed and predicted DDIs was 3.17 for the standard replot method and 1.45 for the numerical method. Similar results were obtained using a synthesis-rate constant of 0.000 32 min -1 . These results suggest that numerical methods can successfully model complex in vitro TDI kinetics and that the resulting DDI predictions are more accurate than those obtained with the standard replot approach.

  14. Studio 1:1

    Index Scriptorium Estoniae

    2011-01-01

    Projekteerimis- ja disainistuudiost STUDIO 1:1 (Eindhoven), mis tegeleb avaliku ruumi loomise ja selle kasutamise kujundamisega. Projektidest "Linnulinn - linn lindude segakogukonna jaoks" ja ICT kogemuskeskus "De Verdieping"

  15. WOOD 1:1

    DEFF Research Database (Denmark)

    2013-01-01

    Report from 1:1 workshop at Virserum Konsthall in May 2013 with a team of Master's students from Royal Academy of Fine Arts, School of Architecture, Dpt. 3.......Report from 1:1 workshop at Virserum Konsthall in May 2013 with a team of Master's students from Royal Academy of Fine Arts, School of Architecture, Dpt. 3....

  16. Effects of Imagined Interactions and Rehearsal on Speaking Performance

    Science.gov (United States)

    Choi, Charles W.; Honeycutt, James M.; Bodie, Graham D.

    2015-01-01

    Imagined interactions (IIs) constitute a type of social cognition that can reduce fear of communication. Through the mental preparation enabled by IIs, an individual can reduce disfluencies and mitigate the anxiety that arises from a speech. Study 1 indicated that rehearsal influences the reduction of silent pauses but not vocalized pauses. In…

  17. resources 1..1

    Indian Academy of Sciences (India)

    http://www.ias.ac.in/jgenet/OnlineResources/90/e34.pdf. Morinha F., Carvalho M., Ferro A., Guedes-Pinto H., Rodrigues R. and Bastos E. 2011 Molecular sexing and analysis of CHD1-Z and. CHD1-W sequence variations in wild common quail (Coturnix c. coturnix) and domesticated Japanese quail (Coturnix c. japonica).

  18. A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules

    International Nuclear Information System (INIS)

    Iimori, Makoto; Ozaki, Kanako; Chikashige, Yuji; Habu, Toshiyuki; Hiraoka, Yasushi; Maki, Takahisa; Hayashi, Ikuko; Obuse, Chikashi; Matsumoto, Tomohiro

    2012-01-01

    Mal3 is a fission yeast homolog of EB1, a plus-end tracking protein (+ TIP). We have generated a mutation (89R) replacing glutamine with arginine in the calponin homology (CH) domain of Mal3. Analysis of the 89R mutant in vitro has revealed that the mutation confers a higher affinity to microtubules and enhances the intrinsic activity to promote the microtubule-assembly. The mutant Mal3 is no longer a + TIP, but binds strongly the microtubule lattice. Live cell imaging has revealed that while the wild type Mal3 proteins dissociate from the tip of the growing microtubules before the onset of shrinkage, the mutant Mal3 proteins persist on microtubules and reduces a rate of shrinkage after a longer pausing period. Consequently, the mutant Mal3 proteins cause abnormal elongation of microtubules composing the spindle and aster. Mal3 is phosphorylated at a cluster of serine/threonine residues in the linker connecting the CH and EB1-like C-terminal motif domains. The phosphorylation occurs in a microtubule-dependent manner and reduces the affinity of Mal3 to microtubules. We propose that because the 89R mutation is resistant to the effect of phosphorylation, it can associate persistently with microtubules and confers a stronger stability of microtubules likely by reinforcing the cylindrical structure. -- Highlights: ► We characterize a mutation (mal3-89R) in fission yeast homolog of EB1. ► The mutation enhances the activity to assemble microtubules. ► Mal3 is phosphorylated in a microtubule-dependent manner. ► The phosphorylation negatively regulates the Mal3 activity.

  19. A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules

    Energy Technology Data Exchange (ETDEWEB)

    Iimori, Makoto; Ozaki, Kanako [Graduate School of Biostudies, Kyoto University, Kitashirakawa-Oiwake cho, Sakyo ku, Kyoto, 606-8502 (Japan); Chikashige, Yuji [Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, Kobe, 651-2492 (Japan); Habu, Toshiyuki [Graduate School of Biostudies, Kyoto University, Kitashirakawa-Oiwake cho, Sakyo ku, Kyoto, 606-8502 (Japan); Radiation Biology Center, Kyoto University, Yoshida-Konoe cho, Sakyo ku, Kyoto, 606-8501 (Japan); Hiraoka, Yasushi [Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, Kobe, 651-2492 (Japan); Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, 565-0871 (Japan); Maki, Takahisa; Hayashi, Ikuko [Graduate School of Nanobioscience, Yokohama City University, Tsurumi, Yokohama, 230-0045 (Japan); Obuse, Chikashi [Graduate School of Life Science, Hokkaido University, Sapporo 001-0021 (Japan); Matsumoto, Tomohiro, E-mail: tmatsumo@house.rbc.kyoto-u.ac.jp [Graduate School of Biostudies, Kyoto University, Kitashirakawa-Oiwake cho, Sakyo ku, Kyoto, 606-8502 (Japan); Radiation Biology Center, Kyoto University, Yoshida-Konoe cho, Sakyo ku, Kyoto, 606-8501 (Japan)

    2012-02-01

    Mal3 is a fission yeast homolog of EB1, a plus-end tracking protein (+ TIP). We have generated a mutation (89R) replacing glutamine with arginine in the calponin homology (CH) domain of Mal3. Analysis of the 89R mutant in vitro has revealed that the mutation confers a higher affinity to microtubules and enhances the intrinsic activity to promote the microtubule-assembly. The mutant Mal3 is no longer a + TIP, but binds strongly the microtubule lattice. Live cell imaging has revealed that while the wild type Mal3 proteins dissociate from the tip of the growing microtubules before the onset of shrinkage, the mutant Mal3 proteins persist on microtubules and reduces a rate of shrinkage after a longer pausing period. Consequently, the mutant Mal3 proteins cause abnormal elongation of microtubules composing the spindle and aster. Mal3 is phosphorylated at a cluster of serine/threonine residues in the linker connecting the CH and EB1-like C-terminal motif domains. The phosphorylation occurs in a microtubule-dependent manner and reduces the affinity of Mal3 to microtubules. We propose that because the 89R mutation is resistant to the effect of phosphorylation, it can associate persistently with microtubules and confers a stronger stability of microtubules likely by reinforcing the cylindrical structure. -- Highlights: Black-Right-Pointing-Pointer We characterize a mutation (mal3-89R) in fission yeast homolog of EB1. Black-Right-Pointing-Pointer The mutation enhances the activity to assemble microtubules. Black-Right-Pointing-Pointer Mal3 is phosphorylated in a microtubule-dependent manner. Black-Right-Pointing-Pointer The phosphorylation negatively regulates the Mal3 activity.

  20. Agrosearch 1 Vol. 1

    African Journals Online (AJOL)

    nutrient index and to determine the variability existing among soil physicochemical ... The area has an altitude of 140 m above sea level. ... Soil pH was determined in distilled water (at the ratio of 1:2:5) and in KCl solution according to. Mclean ...

  1. 1-1-3

    African Journals Online (AJOL)

    tertiary hyperparathyroidism with severe metabolic bone disease. Five patients presented with rapidly progressing calciphylaxis. Three patients had grossly elevated serum calcium levels (l was comatose and 1 was confused) and an emergency parathyroidectomy was performed in these patients. Other symptoms were ...

  2. A Faculty Development Session or Resident as Teacher Session for Didactic and Clinical Teaching Techniques; Part 1 of 2: Engaging Learners with Effective Didactic Teaching

    Directory of Open Access Journals (Sweden)

    Megan Boysen-Osborn

    2016-07-01

    Full Text Available Audience: This workshop is intended for faculty members in an emergency medicine (or other residency program, but is also appropriate for chief residents and medical student educators, including basic science faculty. Introduction: Faculty development sessions are required by the Accreditation Council for Graduate Medical Education and enhance the learning environment within residency programs. Resident as teacher sessions are important in helping residents transition from junior learners to supervisors of medical students and junior residents. Part I of this two-part workshop introduces learners to effective techniques to engaging learners during didactic sessions. Objectives: By the end of this workshop, the learner will: 1 describe eight teaching techniques that encourage active learning during didactic sessions; 2 plan a didactic session using at least one of eight new teaching techniques for didactic instruction. Methods: This educational session is uses several blended instructional methods, including team-based learning (classic and modified, the flipped classroom, audience response systems, pause procedures in order to demonstrate effective didactic teaching techniques.

  3. Funtional MRI of cerebral motor cortex: comparison between 1.0 T and 1.5 T

    International Nuclear Information System (INIS)

    Jang, Hyun Jung; Yu, In Kyu; Song, In Chan; Han, Moon Hee; Lee, Heung Kyu; Chang, Kee Hyun

    1997-01-01

    To evaluate the feasibility of functional MR imaging(fMRI) with a 1.0 T scanner, fMRI of normal cerebral motor cortex at 1.0 T was compared with that at 1.5 T. FMRI of bilateral cerebral motor cortices (left, seven; right, six) was performed in seven healthy male volunteers aged 26-34 (mean 29) years,with BOLD contrast at both 1.0 T and 1.5 T units(Siemens MR scanners). Using both these systems,two-dimensional(2D) FLASH images were obtained with TR/TE of 90/56, flip angle of 40 deg, matrix size 128 * 128, slice thickness of 5mm, and FOV 23cm. A sequence consisting of five-image-off phase(rest phase) followed by five-image-on phase(activation with finger movement) was repeated four times without pause at a single plane. The same study was perfomed for the contralateral motor cortex in each volunteer. Using the z-test, activation images were obtained for the signal difference between on-and off-phases (p<0.05) and were then superimposed on 2D FLASH anatomic images at the same plane. Percentage changes of signal intensities(PCSIs) and numbers of activated pixels were compared, using the non-paramatric t-test, and periodicity of signal changes was compared, using the Mentel-Haenszel Chi-square test. Mean PCSIs at 1.5 T and 1.0 T in the left motor cortex were 3.13 ±1.20% and 1.43±0.56%, respectively(p=0.009),and in the right, 1.78±0.95% and 1.34±0.28%, respectively(p=0.32). The mean number of activated pixels at 1.5 T and 1.0 T in the left cortex was 21.14±10.67 and 19.86±11.36, respectively (p=0.83), and in the right, 22.5±6.47 and 16.8±8.47, respectively (p=0.22). At 1.5 T, periodicity of signal changes was seen in the left cortex in six of seven volunteers, and in the right cortex, in four of six. At 1.0 T, all showed periodicity (left:p=0.32;right:p=0.14). PCSIs in the dominant hemispheres were significantly higher at 1.5 T, but no other indicators showed significant differences between 1.0 T and 1.5 T. Acceptable fMRI can therefore be carried out with a 1

  4. Juba teine "1+1 = 1"

    Index Scriptorium Estoniae

    2004-01-01

    15. III Okupatsioonimuuseumis toimuva "1+1=1" teise ürituse kavast. Presentatsioonide õhtu keskendub konkreetse ruumikogemuse vahendamisele kunstis (helis, slaidi-installatsioonis, tänava-aktsioonis, skulptuuris, videos, filmis). Esinevad Cevdet Erek, Andres Lõo, Andres Kurg (arhitektuur ja interjöörid Marko Raadi filmis "Agent Sinikael") jt.

  5. Decreasing Echolalia of the Instruction "Say" during Echoic Training through Use of the Cues-Pause-Point Procedure

    Science.gov (United States)

    Valentino, Amber L.; Shillingsburg, M. Alice; Conine, Daniel E.; Powell, Nicole M.

    2012-01-01

    Echolalia is common in children with autism and may interfere with the development of functional language. Given the variety of vocal stimuli included in teaching language to children with autism, it is possible that discrimination between instructions and targeted responses may not always occur. Thus, children may engage in very high rates of…

  6. Operation of a quadripole probe on magnetospheric satellite (GEOS experiment). Contribution to cold plasma behaviour study near equatorial plasma pause

    International Nuclear Information System (INIS)

    Decreau-Prior, P.

    1983-06-01

    This thesis is concerned with the exploitation of GEOS Satellite RF quadripole probe measurements, GEOS satellites have explored magnetosphere on the geostationary orbit and around it. Results a low to qualify the instrument in magnetospheric plasma (previously, it had been used only in ionosphere). Furthermore existence, outside the outer plasmasphere, of a cold population (from 0,4 to 8 eV) with medium density (from 2 to 50 particles cm -3 ) is shown. This population had been ignored until then, by in situ particle measure experiment. So, new perspectives on coupling nature of the explored region with ionosphere, and with plasma sheet, more particularly because the temperature measured at the equator is on an average, clearly higher than in high ionosphere the principal source of magnetospheric cold plasma [fr

  7. Life's pregnant pause of pain: pregnant women's experiences of pelvic girdle pain related to daily life: a Swedish interview study.

    Science.gov (United States)

    Elden, Helen; Lundgren, Ingela; Robertson, Eva

    2013-03-01

    Pelvic girdle pain (PGP) is a universally disabling condition affecting three of 10 pregnant women. Qualitative studies on the subject are lacking. To describe pregnant women's experiences of PGP as related to daily life. In all, 27 women with PGP participating in a randomised controlled study were interviewed during 2010-2011. Qualitative content analysis was used. Five main categories emerged: PGP affects the ability to cope with everyday life; Coping with motherhood; Relationships between partners often reached the breaking point; Questioning one's identity as defined by profession and work, and Lessons learned from living with PGP. The categories illustrate how women's everyday lives were interrupted. Their inability to meet their own and others' expectations put a strain on their lives causing disappointment, sadness and frustration. It made them question and doubt their roles and identities as mothers, partners and professionals, and kept them from looking forward to future pregnancies, in the absence of effective treatment for PGP. Knowledge gained was that women with PGP should seek help immediately, listen to their bodies, and acknowledge their limitations. PGP severely affects pregnant women's everyday lives. There appears to be a lack of knowledge and awareness in general, as well as among caregivers and employers of PGP that needs to be highlighted and rectified. There is also a great need to learn how to support those suffering from it. Appropriate support during this important and rare phase in a woman's life is highly warranted. Copyright © 2012 Elsevier B.V. All rights reserved.

  8. Children with Dyslexia Are Slow Writers Because They Pause More Often and Not Because They Are Slow at Handwriting Execution

    Science.gov (United States)

    Sumner, Emma; Connelly, Vincent; Barnett, Anna L.

    2013-01-01

    It is commonly assumed that children with dyslexia are slower at handwriting than other children. However, evidence of slow handwriting in children with dyslexia is very mixed. Thirty-one children with dyslexia, aged 9 years, were compared to both age-matched children and younger spelling-ability matched children. Participants completed an…

  9. Cardiohemodynamic and electrophysiological effects of a selective EP4 receptor agonist ONO--AE1--329 in the halothane-anesthetized dogs.

    Science.gov (United States)

    Nomura, Hiroaki; Nakamura, Yuji; Cao, Xin; Honda, Atsushi; Katagi, Jun; Ohara, Hiroshi; Izumi-Nakaseko, Hiroko; Satoh, Yoshioki; Ando, Kentaro; Sugiyama, Atsushi

    2015-08-15

    Cardiovascular effects of a highly selective prostaglandin E2 type 4 (EP4) receptor agonist ONO-AE1-329 were assessed with the halothane-anesthetized dogs (n=6). ONO-AE1-329 was intravenously infused in three escalating doses of 0.3, 1 and 3ng/kg/min for 10min with a pause of 20min between the doses. The low dose of 0.3ng/kg/min significantly increased maximum upstroke velocity of left ventricular pressure by 18% at 20min, indicating increase of ventricular contractility. The middle dose of 1ng/kg/min significantly decreased total peripheral resistance by 24% and left ventricular end-diastolic pressure by 32% at 10min, indicating dilation of arteriolar resistance vessels and venous capacitance ones, respectively; and increased cardiac output by 25% at 10min in addition to the change induced by the low dose. The high dose of 3ng/kg/min increased heart rate by 34% at 10min; decreased mean blood pressure by 14% at 10min and atrioventricular nodal conduction time by 13% at 5min; and shortened left ventricular systolic period by 8% at 10min and electromechanical coupling defined as an interval from completion of repolarization to the start of ventricular diastole by 39% at 10min in addition to the changes induced by the middle dose. No significant change was detected in a ventricular repolarization period. These results indicate that ONO-AE1-329 may possess a similar cardiovascular profile to typical phosphodiesterase 3 inhibitors as an inodilator, and suggest that EP4 receptor stimulation can become an alternative strategy for the treatment of congestive heart failure. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Educational Modelling Language 1.1 (EML 1.1)

    NARCIS (Netherlands)

    Koper, Rob; Vogten, Hubert; Martens, Harrie

    2003-01-01

    Package contains the EML 1.1 dtd, schema and documentation as is created for the Edubox Player. It is slightly different from IMS Learning Design and provides an intermediate solution between EML 1.0 and IMD Learning Design. The Edubox Player 3.x works on EML 1.1. This package is stored for

  11. CHAPTER 1

    African Journals Online (AJOL)

    Dr Olaleye

    an ordered pair of real numbers (x, y) called its. Cartesian ... Denotes A1 X A2 X - - - Am = { ( a1, a2, - - - am)/ ai ϵAi and i=1, 2, - - -, m }. Subsets of .... Using Matrices to denote Cartesian Products of the set. G = { T, I, Z } The table of the Cartesian product G X. G is the table of first phyla generation of nine different families. X. T.

  12. CHAPTER 1

    African Journals Online (AJOL)

    Dr Olaleye

    1Non-steroidal drugs, cigarettes, alcohol usage,. Helicobacter pylori, and stress have been shown to contribute to gastric ulcer formation (Mózsik, and Jávor,. 1988 ... E-mail: chinedukwa1@gmail.com. Tel: +234-8053601577. Date Received: March, 2015. Date Accepted:, May, 2015. 2011). Many of the anti-ulcer drugs in ...

  13. Supplementary 1

    Indian Academy of Sciences (India)

    moj

    The name and origin of studied oily sunflower genotypes under well watered and water stressed conditions over two years. No. Name. Origin. Research centre No. Name. Origin. Research centre. 1 H100A/83HR4 France. ASGROW. 51 RHA265. France. ASGROW. 2 H209A/LC1064 France. ASGROW. 52 PM1-3. USA.

  14. CHAPTER 1

    African Journals Online (AJOL)

    Dr Olaleye

    while 53.2% engaged in moderate physical fitness 1-2 days a week but less than 30 minutes per day. Only few (26.1%) received .... physical activity such as brisk walking and cycling lasting for at least 30 min/day, to be observed at ..... (2011): Exposing women to workplace stress factors as a risk factor for developing arterial ...

  15. CHAPTER 1

    African Journals Online (AJOL)

    Dr Olaleye

    Apoptosis plays an important role in the treatment of cancer, as it is a common target of many treatment schemes. We aim to investigate the expression of and relationship between PD-1, PD-L1 and PD-L2 in OSCC. This is important because there are now immunotherapies that target the cell programmed death pathway.

  16. The influence of emotion regulation, attribution prompts, and delay, on response aggressiveness in antisocial boys. [IF 1.3

    OpenAIRE

    Orobio de Castro, B.; Bosch, J.D.; Veerman, J.W.; Koops, W.

    2003-01-01

    Boys with aggressive behavior problems are frequently taught to "stop and think" before they act. In provocative situations, pausing to monitor their own feelings, to consider the feelings of others, or to delay their response is believed to reduce aggressive behavior. This study aimed to test these assumptions. Thirty-two highly aggressive boys in special education and 31 normal comparison boys were presented vignettes concerning provocation by a peer and given specific cognitive assignments...

  17. ASC-1

    DEFF Research Database (Denmark)

    Jakimoski, Goce; Khajuria, Samant

    2011-01-01

    uses leak extraction from diÆerent AES rounds to compute the key material that is XOR-ed with the message to compute the ciphertext. Unlike LEX, the ASC-1 operates in a CFB fashion to compute an authentication tag over the encrypted message. We argue that ASC-1 is secure by reducingits (IND-CCA , INT......The goal of the modes of operation for authenticated encryption is to achieve faster encryption and message authentication by performing both the encryption and the message authentication in a single pass as opposed to the traditional encrypt-then-mac approach, which requires two passes....... Unfortunately, the use of a block cipher as a building block limits the performance of the authenticated encryption schemes to at most one message block per block cipher evaluation. In this paper, we propose the authenticated encryption scheme ASC-1 (Authenticating Stream Cipher One). Similarly to LEX, ASC-1...

  18. CCR1

    African Journals Online (AJOL)

    inflammatory protein II; Bioinformatics; Protease digestion; HEK293 cells; Radioligand binding. Tropical ... development of many diseases. ... diseases, antagonism of CCR1 has become an ..... importance of molecular conformation in terms of.

  19. 1Facu

    African Journals Online (AJOL)

    USER

    2014-12-02

    Dec 2, 2014 ... This study aimed to assess financial feasibility of traditional small-scale ... enterprises that received microcredit from local commercial bank could repay fully principal and ..... accounting for 96.1% of the total investment.

  20. CHAPTER 1

    African Journals Online (AJOL)

    Dr Olaleye

    1Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, Olabisi ... 2Department of Medicine, Endocrinology unit, Olabisi Onabanjo University Teaching .... mellitus who received medical care from endocrinology clinic.

  1. 1/N

    International Nuclear Information System (INIS)

    Coleman, S.

    1980-03-01

    There exist families of field theories with symmetry group SO(N) (or SU(N)) that become simpler as N becomes larger. More precisely, the solutions to these theories possess an expansion in powers of 1/N. This expansion is the subject of these lectures. The 1/N expansion can be used to analyze model field theories. The 1/N expansion is developed for phi 4 theory and applied to two two-dimensional models with similar combinatoric structures, the Gross-Neveu model and the CP/sup N-1/ model. These models display (in the leading 1/N approximation) such interesting phenomena as asymptotic freedom, dynamical symmetry breaking, dimensional transmutation, and non-perturbative confinement. It is possible that the 1/N expansion, with N the number of colors, might fruitfully be applied to quantum chromodynamics. Unfortunately, it is not possible to make a decisive test of the approximation, because no one knows how to compute even the first term in the expansion in closed form. However, it is possible to argue that this first term, whatever its detailed form, has many properties that are also shared by the real world, and which are otherwise underived from field theory. These include the saturation of scattering amplitudes by an infinite number of narrow resonances, the essential feature of dual-resonance models

  2. RHM 1(1).indb

    African Journals Online (AJOL)

    mike

    Research in Hospitality Management 2011, 1(1): 43–52 ... Innovating concepts are becoming ever ... hospitality industry the concept of employer branding as ... Keywords: employer branding, hospitality industry, human resources management, strategy ..... is not much evidence on employer branding beyond cases.

  3. RHM 1(1).indb

    African Journals Online (AJOL)

    mike

    Research in Hospitality Management 2011, 1(1): 31–35. Printed in South ... perspective of tourism, this research examines the branding strategies of Qatar. To the Qatari, the ... and attempt to present the case of this country through broad description ... In this paper, the dreamland concept forms a framework for reflecting on ...

  4. author's correction 1..1

    Indian Academy of Sciences (India)

    J. Genet. 89, e25Ye29 (http://www.ias.ac.in/jgenet/OnlineResources/90/e25.pdf). In table 1, for locus Aaz1, the core motif should be (ACAT)8 ATAAA(TG)6 and not (ACAT)8. Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement in smoking behaviour. Maria Angelica Ehara Watanabe, Sandra Odebrechet ...

  5. 1+1 Gaudin Model

    Directory of Open Access Journals (Sweden)

    Andrei V. Zotov

    2011-07-01

    Full Text Available We study 1+1 field-generalizations of the rational and elliptic Gaudin models. For sl(N case we introduce equations of motion and L-A pair with spectral parameter on the Riemann sphere and elliptic curve. In sl(2 case we study the equations in detail and find the corresponding Hamiltonian densities. The n-site model describes n interacting Landau-Lifshitz models of magnets. The interaction depends on position of the sites (marked points on the curve. We also analyze the 2-site case in its own right and describe its relation to the principal chiral model. We emphasize that 1+1 version impose a restriction on a choice of flows on the level of the corresponding 0+1 classical mechanics.

  6. Osborne 1

    CERN Multimedia

    1981-01-01

    The Osborne 1 Released by the Osborne Computer Corporation is considered to be the first true portable, full-featured computer intended for a larger audience than companies. It includes all the components required to be a completely useful and operational computer system. Indeed the Osborne 1 was cost $ 1,795which is now $ 4,773. Another attractive point was that it was sold with several software, which, sold separately, cost almost the same price as the machine. However this computer has some disadvantages like its weight (11 kg) or its tiny screen that could display only a little character per lines and sized the average size of a phone screen . Another problem was that the computer was a bit prone to overheating.

  7. Kjemi 1

    DEFF Research Database (Denmark)

    Brandt, Harald; Hushovd, Odd T.

    Kemi 1 er en lærebog til den gymnasiale kemiundervisning i Norge (VG2, studieforberedende) tilsvarende det danske kemi B-niveau i det almene gymnasium (stx). Lærebogen er et del af af et bogsystem med tilhørende netsted til elever og online-lærervejledning (lokus.no).......Kemi 1 er en lærebog til den gymnasiale kemiundervisning i Norge (VG2, studieforberedende) tilsvarende det danske kemi B-niveau i det almene gymnasium (stx). Lærebogen er et del af af et bogsystem med tilhørende netsted til elever og online-lærervejledning (lokus.no)....

  8. POLX-1

    International Nuclear Information System (INIS)

    Ras, H.

    1991-03-01

    The capabilities of the POLX-1 code which was developed for the purpose of generating polynomial fits to neutron few-group cross sections as functions of soluble boron concentration, fuel temperature, moderator density and exposure in the reactor core are described. The effects of extracting removable burnable poison rods and the insertion of control rods are also parameterized as functions of the core conditions. Input data requirements and the format of the output file generated by POLX-1 are also described. 14 refs

  9. RHM 1(1).indb

    African Journals Online (AJOL)

    mike

    Do social media display correct conventional hotel ratings? Wouter Hensens*1, Miemie .... tourists are satisfied and delighted to spread positive word of mouth about the destination (World Tourism Organisation,. 2004). Such claims go hand in ...

  10. CHAPTER 1

    African Journals Online (AJOL)

    Dr Olaleye

    A Biometric Study of Some Reproductive Components of the. Male Domestic Local Breed Cat (Felis catus domestica) in. Northwest Nigeria. *1M.A Umaru;2 A. Bello; ... and security test for new drugs (Elcock and Schoning,. 1984). Little information is available regarding the morphology and biometry of the male genitalia of ...

  11. Appendix 1

    African Journals Online (AJOL)

    Blyth's Reed Warbler x Marsh Warbler hybrid Acrocephalus dumetorum x A. palustris ............1. Number of .... in May 2009 when the finding date was given as “in December. 2005” ...... worn, brown wing feathers would not be replaced until the ...

  12. CHAPTER 1

    African Journals Online (AJOL)

    Dr Olaleye

    2001-02-01

    Feb 1, 2001 ... research and financial institutions; acquiring famous faculty; multidisciplinary science replacing single disciplines; and .... patents issued for the fiscal year 2007 (Market Research ... is reducible to one of three categories –war, crises, or ..... ccismay042700.html> The Graduate School of International.

  13. Slide 1

    Indian Academy of Sciences (India)

    Game Theory · Strategic Form Games (Normal Form Games) · Example : Prisoner's Dilemma · Dominant Strategy Equilibrium · Nash Equilibrium · Nash's Theorem · Slide 17 · Slide 18 · Example 1: Mechanism Design Fair Division of a Cake · Example 2: Mechanism Design Truth Elicitation through an Indirect Mechanism.

  14. 1. Editorial

    African Journals Online (AJOL)

    Sitwala

    At 6.2 , Zambia has one of the highest fertility rates in the world and yet over 50% of women deliver at. 1 home being ... nutrients especially in the resource poor nations. Several factors ... population, this is equal to 12% of the increase in. 8.

  15. CHAPTER 1

    African Journals Online (AJOL)

    Dr Olaleye

    1Department of Physiotherapy, Faculty of College Allied Health Sciences, Bayero University, Kano, Nigeria ... motor recovery on QoL of Nigerian stroke survivors in the acute and sub-acute stages of recovery is .... instruments include the World Health Organization .... Preedly VR and Ronald R Watson (eds) Handbook of.

  16. Book 1

    African Journals Online (AJOL)

    was associated with high consumption of legumes and the use of kerosene in cooking stoves. ... maternal occupation (OR=15.4; CI 1.78-132.8), and educational attainment ... establishment of community genetic services particularly those related to .... Social class 2,3 (Teachers, ..... Janeiro, Brazil: Prevalence and associ-.

  17. Slide 1

    Indian Academy of Sciences (India)

    Projected Rainfall (Weighted Mean CDF; A1B scenario) · Slide 18 · Imprecise Probability · Bounds for Probability of Drought · Slide 21 · Possibility Distribution of GCMs and Scenarios · Mahanadi River Basin - Streamflow · Projections for future monsoon inflows to Hirakud Reservoir · Slide 25 · Rule curve for adaptive policies.

  18. CHAPTER 1

    African Journals Online (AJOL)

    Dr Olaleye

    Department of Biological Sciences, College of Science, Engineering and Technology Minnesota State University,. Mankato, MN 56001 .... in a cage that is placed on a receiver plate connected to a computer. Each telemetry device is assigned a code and hence could be used for different animals at a given time. Fig. 1: Total ...

  19. Danida1

    DEFF Research Database (Denmark)

    Henriksen, Mogens

    1996-01-01

    At the request of Danish Ministry of Foreign Affairs, Department TSA.4, electrical testing of possibly damaged cables has been evaluated. This matter concerns three different types of cable, which are10 km 30(36) kV XLPE armoured submarine power cable, 1-phase15 km 30(36) kV XLPE armoured...

  20. CHAPTER 1

    African Journals Online (AJOL)

    Dr Olaleye

    interviewer administered questionnaire containing a 47- point knowledge scale were used for data collection. Data were analysed ... FMOH guidelines. The contraceptives ever dispensed by respondents included: male condoms (96.1%), female condoms (4.3%), .... every wrong response had zero mark. Maximum.

  1. CASE 1

    African Journals Online (AJOL)

    Guest

    Introduction. In Nigerians bladder calculi account for 44.4%2 while in North America, they account for 5%1 urinary calculi 2 .Infection and bladder foreign bodies seem to be predisposing. Giant vesical calculus may be defined as a stone in the urinary bladder weighing more than 100g. Giant vesical stones are universally ...

  2. dad1

    Indian Academy of Sciences (India)

    PRAKASH

    (Moharikar et al 2006) and yeast (Madeo et al 2002; Del. Carratore et al 2002; Herker .... DAD1 mutation in animal cells (Tanaka et al 1997), and may therefore function as a ... follow its expression during UV-C induced apoptotic-like cell death.

  3. CHAPTER 1

    African Journals Online (AJOL)

    Dr Olaleye

    Pregnancy outcome in different clinical phenotypes of antiphospholipid syndrome. Lupus Jan 19(1):58-64. Christensson A., Ekberg J., Grubb A., Ekberg H.,. Lindstrom V and Lilja H. (2003). Serum cystatin C is a more sensitive and more accurate marker of glomerular filtration rate than enzymatic measurements of creatinine ...

  4. Slide 1

    Indian Academy of Sciences (India)

    Table of contents. Slide 1 · Slide 2 · Slide 3 · Slide 4 · Slide 5 · Slide 6 · Slide 7 · Slide 8 · Slide 9 · Slide 10 · Slide 11 · Slide 12 · Slide 13 · Slide 14 · Slide 15 · Slide 16 · Slide 17.

  5. Datablock: 1

    Indian Academy of Sciences (India)

    2017-05-17

    May 17, 2017 ... Sum formula. C24 H66 Mo5 N6 ... PLAT250_ALERT_2_C Large U3/U1 Ratio for Average U(i,j) Tensor .... 3.9 Note .... to identify outliers and unusual parameters, but every test has its limitations and alerts that are not important.

  6. CHAPTER 1

    African Journals Online (AJOL)

    Dr Olaleye

    Methods: Fifty-five (55) male albino rats (250-300g) were randomly divided in a blinded fashion into 5 oral treatment groups as follow: Group I (control, n=5) received 10% ethanol (1 ...... cannabis use in adolescence: 10-year follow-up study.

  7. Panel 1

    DEFF Research Database (Denmark)

    Homøe, Preben; Kværner, Kari; Casey, Janet R

    2017-01-01

    Objective To create a literature review between 2011 and June 1, 2015, on advances in otitis media (OM) epidemiology and diagnosis (including relevant audiology studies). Data Sources Electronic search engines (PubMed, EMBASE, and Cochrane Library) with a predefined search strategy. Review Methods...

  8. Piezo1

    Science.gov (United States)

    Gottlieb, Philip A.; Sachs, Frederick

    2012-01-01

    Piezo ion channels have been found to be essential for mechanical responses in cells. These channels were first shown to exist in Neuro2A cells, and the gene was identified by siRNAs that diminished the mechanical response. Piezo channels are approximately 2500 amino acids long, have between 24–32 transmembrane regions, and appear to assemble into tetramers and require no other proteins for activity. They have a reversal potential around 0 mV and show voltage dependent inactivation. The channel is constitutively active in liposomes, indicating that no cytoskeletal elements are required. Heterologous expression of the Piezo protein can create mechanical sensitivity in otherwise insensitive cells. Piezo1 currents in outside-out patches were blocked by the extracellular MSC inhibitor peptide GsMTx4. Both enantiomeric forms of GsMTx4 inhibited channel activity in a manner similar to endogenous mechanical channels. Piezo1 can adopt a tonic (non-inactivating) form with repeated stimulation. The transition to the non-inactivating form generally occurs in large groups of channels, indicating that the channels exist in domains, and once the domain is compromised, the members simultaneously adopt new properties. Piezo proteins are associated with physiological responses in cells, such as the reaction to noxious stimulus of Drosophila larvae. Recent work measuring cell crowding, shows that Piezo1 is essential for the removal of extra cells without apoptosis. Piezo1 mutations have also been linked to the pathological response of red blood cells in a genetic disease called Xerocytosis. These finding suggest that Piezo1 is a key player in cells’ responses to mechanical stimuli. PMID:22790400

  9. Slide 1

    Indian Academy of Sciences (India)

    Table of contents. Slide 1 · Slide 2 · Membrane Phospholipids · Slide 4 · NAE and NAPE · Biological and Pharmacological properties · Slide 7 · Slide 8 · Slide 9 · Slide 10 · Slide 11 · Slide 12 · Slide 13 · Slide 14 · Slide 15 · Slide 16 · Slide 17 · Slide 18 · Slide 19 · Slide 20 · Slide 21 · Slide 22 · Slide 23 · Slide 24 · Slide 25.

  10. Slide 1

    Indian Academy of Sciences (India)

    Table of contents. Slide 1 · Matsyagandhya A case of genetic disorder · Slide 3 · Slide 4 · Slide 5 · Slide 6 · Slide 7 · Active Site with Molybdopterin Ligation · Disadvantage of a Chemist to Model the Cofactor · Slide 10 · Slide 11 · Slide 12 · Active Site Investigation · Slide 14 · Slide 15 · Slide 16 · Slide 17 · Slide 18 · Slide 19.

  11. RECONS-1

    International Nuclear Information System (INIS)

    Mueller, E.Z.

    1991-03-01

    The capabilities and input data requirements of the data processing program RECONS-1 which can be used as a stand-alone code, or as a module of an overall reactor calculational package, to generate microscopic and macroscopic few-group LWR assembly (nodal) cross section data from a pretabulated library of quadratic polynomials are described. RECONS-1 is intended for applications in which a microscopic reactor depletion model is adopted. The polynomial library is required to have a specific format which is designed to represent assembly data as a function of the physical conditions to be encountered during the normal operating history of an LWR. These conditions include the global reactor soluble boron concentration (for PWRs), the local exposure, average fuel temperature and average moderator density of each assembly/node. Provision is also made for adjustments to the nodewise cross sections to account for the presence of control rod clusters and/or the withdrawal of removable burnable absorber rods at any point during the operating history of a reactor. All these facilities as well as others which might be incorporated by the user of RECONS-1 are discussed in some detail. Possible future enhancements are also discussed. 11 refs

  12. Pentacene on Au(111), Ag(111) and Cu(111): From physisorption to chemisorption.

    Science.gov (United States)

    Lu, Meng-Chao; Wang, Rong-Bin; Yang, Ao; Duhm, Steffen

    2016-03-09

    We measured the electronic and the molecular surface structure of pentacene deposited on the (111)-surfaces of coinage metals by means of ultraviolet photoelectron spectroscopy (UPS) and low-energy electron diffraction (LEED). Pentacene is almost flat-lying in monolayers on all three substrates and highly ordered on Au(111) and on Cu(111). On Ag(111), however, weak chemisorption leads to almost disordered monolayers, both, at room temperature and at 78 K. On Cu(111) pentacene is strongly chemisorbed and the lowest unoccupied molecular orbital becomes observable in UPS by a charge transfer from the substrate. On Ag(111) and Cu(111) multilayers adopt a tilted orientation and a high degree of crystallinity. On Au(111), most likely, also in multilayers the molecular short and long axes are parallel to the substrate, leading to a distinctively different electronic structure than on Ag(111) and Cu(111). Overall, it could be demonstrated that the substrate not only determines the geometric and electronic characteristics of molecular monolayer films but also plays a crucial role for multilayer film growth.

  13. Slide 1

    Indian Academy of Sciences (India)

    Table of contents. Slide 1 · Slide 2 · Slide 3 · Slide 4 · Slide 5 · Slide 6 · Slide 7 · Immunology of VL · Slide 9 · Slide 10 · Slide 11 · Slide 12 · Slide 13 · Slide 14 · Strategies To Design Drugs · Slide 16 · Slide 17 · Slide 18 · Slide 19 · Slide 20 · Slide 21 · Slide 22 · Slide 23 · Slide 24 · Slide 25 · Slide 26 · Slide 27 · Slide 28.

  14. Forsmark 1

    International Nuclear Information System (INIS)

    Fredell, J.; Henriksson, T.

    1981-12-01

    ASEA-ATOM carried out an experiment in Forsmark 1 in 1978, in conjunction with discharge test, by means of the safety/relief valves. The tests have been carried out for the case of single valve actuation (SVA), multiple valve actuations (MVA) and consecutive valve actuations (CVA). During MVA tests, up to 12 valves have been used. One of the aims of the experiment was to confirm the operation of the new design of mitigator of the discharge pipes and another was to survey the pressure oscillations in the pool and the vibratory behaviour of the structures and components. The results of these measurements are presented in a number of reports. This report contains an abstract of the results of the measurements presented in these reports. This report also describes the theoretical background and comparisons between test and theoretical results. It is clear that very good agreement has been established between earlier steam discharge experiments, using a mitigator of the type fitted in Forsmark 1, and this experiment. This is based on the fact the amplitude, frequency and distribution of the pressure oscillations in the condensation pool are basically equal to the values predicted by calculations based on the earlier experiments. The low maximum acceleration amplitudes predicted by the beam type structural model have been confirmed, but the frequency content of the response is not very well represented by this type of model. The shell-beam finite element model of the structure gives better agreement with the measured frequency. (author)

  15. 1-(Benzyloxynaphthalene

    Directory of Open Access Journals (Sweden)

    Perumal Venkatesan

    2011-08-01

    Full Text Available In the title compound, C17H14O, the dihedral angle between the naphthyl ring system and the benzyl group is 83.22 (4°. Both of these moieties are planar, with mean deviations from their least-squares planes, defined by the naphthyl ring C atoms and the O atom, and the phenyl ring C atoms and the benzyl α-C atom, of 0.0176 (1 and 0.0024 (13 Å, respectively. The crystal structure is stabilized by C—H...π and π–π interactions [centroid–centroid distance = 3.7817 (10 Å].

  16. 1-Benzylimidazolium hexafluorophosphate–1-benzylimidazole (1/1

    Directory of Open Access Journals (Sweden)

    Qing-Xiang Liu

    2008-02-01

    Full Text Available In the title compound, C10H11N2+·PF6−·C10H10N2, the H atom involved in protonation is disordered equally between the cation and the neutral molecule. The dihedral angle between the phenyl and imidazole rings is 82.6 (2°. In the crystal structure, there are head-to-tail π–π stacking interactions between imidazole rings; the interplanar separation is 3.295 (1 Å and the centroid–centroid separation is 3.448 (3 Å. In the centrosymmetric anion, two F atoms are disordered over two positions; the refined site-occupancy factors are 0.855 (11 and 0.145 (11.

  17. Effects of a prostagrandin EP4-receptor agonist ONO-AE1-329 on the left ventricular pressure-volume relationship in the halothane-anesthetized dogs.

    Science.gov (United States)

    Honda, Atsushi; Nakamura, Yuji; Ohara, Hiroshi; Cao, Xin; Nomura, Hiroaki; Katagi, Jun; Wada, Takeshi; Izumi-Nakaseko, Hiroko; Ando, Kentaro; Sugiyama, Atsushi

    2016-03-15

    Cardiac effects of a prostagrandin EP4-receptor agonist ONO-AE1-329 were assessed in the halothane-anesthetized dogs under the monitoring of left ventricular pressure-volume relationship, which were compared with those of clinically recommended doses of dopamine, dobutamine and milrinone (n=4-5 for each treatment). ONO-AE1-329 was intravenously administered in doses of 0.3, 1 and 3 ng/kg/min for 10 min with a pause of 20 min. Dopamine in a dose of 3 µg/kg/min for 10 min, dobutamine in a dose of 1 µg/kg/min for 10 min and milrinone in a dose of 5 µg/kg/min for 10 min followed by 0.5 µg/kg/min for 10 min were intravenously administered. Low dose of ONO-AE1-329 increased the stroke volume. Middle dose of ONO-AE1-329 increased the cardiac output, left ventricular end-diastolic volume, ejection fraction, maximum upstroke/downstroke velocities of the left ventricular pressure and external work, but decreased the end-systolic pressure and internal work besides the change by the low dose. High dose of ONO-AE1-329 increased the heart rate and maximum elastance, but decreased the end-systolic volume besides the changes by the middle dose. Dopamine, dobutamine and milrinone exerted essentially similar cardiac effects to ONO-AE1-329, but they did not significantly change the end-diastolic volume, end-systolic volume, stroke volume, ejection fraction, end-systolic pressure, maximum elastance, external work or internal work. Thus, EP4-receptor stimulation by ONO-AE1-329 may have potential to better promote the passive ventricular filling than the conventional cardiotonic drugs, which could become a candidate of novel therapeutic strategy for the treatment of heart failure with preserved ejection fraction. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Proceedings of the Annual Conference of the Military Testing Association (27th) Held in San Diego, California on 21-25 October 1985. Volume 1

    Science.gov (United States)

    1985-10-25

    speeded test to be distracted or pause to ask a question of the proctor. Extraordinarily long response times should be identified and omitted from the...actual navigation: if only relevant information is presented, irrelevant information cannot be distracting . Much research (Wittig & Petersen, 1979) has...likelihood +hat a s’- ole soldie wil defect a -, articular t~e -.4 ehicle under sorre situation, specifyinig distance. atimcsoh’eric cond~tions

  19. CH{sub 4} dehydrogenation on Cu(1 1 1), Cu@Cu(1 1 1), Rh@Cu(1 1 1) and RhCu(1 1 1) surfaces: A comparison studies of catalytic activity

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Riguang; Duan, Tian [Key Laboratory of Coal Science and Technology of Ministry of Education and Shanxi Province, Taiyuan University of Technology, Taiyuan 030024, Shanxi (China); Ling, Lixia [Key Laboratory of Coal Science and Technology of Ministry of Education and Shanxi Province, Taiyuan University of Technology, Taiyuan 030024, Shanxi (China); Research Institute of Special Chemicals, Taiyuan University of Technology, Taiyuan 030024, Shanxi (China); Wang, Baojun, E-mail: wangbaojun@tyut.edu.cn [Key Laboratory of Coal Science and Technology of Ministry of Education and Shanxi Province, Taiyuan University of Technology, Taiyuan 030024, Shanxi (China)

    2015-06-30

    Highlights: • Adsorbed Rh atom on Cu catalyst exhibits better catalytic activity for CH{sub 4} dehydrogenation. • The adsorbed Rh atom is the reaction active center for CH{sub 4} dehydrogenation. • The morphology of Cu substrate has negligible effect on CH{sub 4} dehydrogenation. - Abstract: In the CVD growth of graphene, the reaction barriers of the dehydrogenation for hydrocarbon molecules directly decide the graphene CVD growth temperature. In this study, density functional theory method has been employed to comparatively probe into CH{sub 4} dehydrogenation on four types of Cu(1 1 1) surface, including the flat Cu(1 1 1) surface (labeled as Cu(1 1 1)) and the Cu(1 1 1) surface with one surface Cu atom substituted by one Rh atom (labeled as RhCu(1 1 1)), as well as the Cu(1 1 1) surface with one Cu or Rh adatom (labeled as Cu@Cu(1 1 1) and Rh@Cu(1 1 1), respectively). Our results show that the highest barrier of the whole CH{sub 4} dehydrogenation process is remarkably reduced from 448.7 and 418.4 kJ mol{sup −1} on the flat Cu(1 1 1) and Cu@Cu(1 1 1) surfaces to 258.9 kJ mol{sup −1} on RhCu(1 1 1) surface, and to 180.0 kJ mol{sup −1} on Rh@Cu(1 1 1) surface, indicating that the adsorbed or substituted Rh atom on Cu catalyst can exhibit better catalytic activity for CH{sub 4} complete dehydrogenation; meanwhile, since the differences for the highest barrier between Cu@Cu(1 1 1) and Cu(1 1 1) surfaces are smaller, the catalytic behaviors of Cu@Cu(1 1 1) surface are very close to the flat Cu(1 1 1) surface, suggesting that the morphology of Cu substrate does not obviously affect the dehydrogenation of CH{sub 4}, which accords with the reported experimental observations. As a result, the adsorbed or substituted Rh atom on Cu catalyst exhibit a better catalytic activity for CH{sub 4} dehydrogenation compared to the pure Cu catalyst, especially on Rh-adsorbed Cu catalyst, we can conclude that the potential of synthesizing high-quality graphene with the

  20. SU-G-JeP1-06: Correlation of Lung Tumor Motion with Tumor Location Using Electromagnetic Tracking

    Energy Technology Data Exchange (ETDEWEB)

    Muccigrosso, D; Maughan, N; Parikh, P [Washington University School of Medicine, Saint Louis, MO (United States); Schultejans, H; Bera, R [Lindbergh High School, St. Louis, MO (United States)

    2016-06-15

    Purpose: It is well known that lung tumors move with respiration. However, most measurements of lung tumor motion have studied long treatment times with intermittent imaging; those populations may not necessarily represent conventional LINAC patients. We summarized the correlation between tumor motion and location in a multi-institutional trial with electromagnetic tracking, and identified the patient cohort that would most benefit from respiratory gating. Methods: Continuous electromagnetic transponder data (Varian Medical, Seattle, WA) of lung tumor motion was collected from 14 patients (214 total fractions) across 3 institutions during external beam radiation therapy in a prospective clinical trial (NCT01396551). External intervention from the clinician, such as couch shifts, instructed breath-holds, and acquisition pauses, were manually removed from the 10 Hz tracking data according to recorded notes. The average three-dimensional displacement from the breathing cycle’s end-expiratory to end-inhalation phases (peak-to-peak distance) of the transponders’ isocenter was calculated for each patient’s treatment. A weighted average of each isocenter was used to assess the effects of location on motion. A total of 14 patients were included in this analysis, grouped by their transponders’ location in the lung: upper, medial, and lower. Results: 8 patients had transponders in the upper lung, and 3 patients each in the medial lobe and lower lung. The weighted average ± standard deviation of all peak-to-peak distances for each group was: 1.04 ± 0.39 cm in the lower lung, 0.56 ± 0.14 cm in the medial lung, and 0.30 ± 0.06 cm in the upper lung. Conclusion: Tumors in the lower lung are most susceptible to excessive motion and daily variation, and would benefit most from continuous motion tracking and gating. Those in the medial lobe might be at moderate risk. The upper lobes have limited motion. These results can guide different motion management strategies

  1. 30 CFR 1.1 - Official emblem.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Official emblem. 1.1 Section 1.1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND OMB CONTROL NUMBERS... OFFICIAL EMBLEM § 1.1 Official emblem. The following emblem is established and shall be used as the...

  2. Metabolism of 1-fluoro-1,1,2-trichloroethane, 1,2-dichloro-1,1-difluoroethane, and 1,1,1-trifluoro-2-chloroethane.

    Science.gov (United States)

    Yin, H; Jones, J P; Anders, M W

    1995-03-01

    1-Fluoro-1,1,2-trichloroethane (HCFC-131a), 1,2-dichloro-1,1-difluoroethane (HCFC-132b), and 1,1,1-trifluoro-2-chloroethane (HCFC-133a) were chosen as models for comparative metabolism studies on 1,1,1,2-tetrahaloethanes, which are under consideration as replacements for ozone-depleting chlorofluorocarbons (CFCs). Male Fischer 344 rats were given 10 mmol/kg ip HCFC-131a or HCFC-132b or exposed by inhalation to 1% HCFC-133a for 2 h. Urine collected in the first 24 h after exposure was analyzed by 19F NMR and GC/MS and with a fluoride-selective ion electrode for the formation of fluorine-containing metabolites. Metabolites of HCFC-131a included 2,2-dichloro-2-fluoroethyl glucuronide, 2,2-dichloro-2-fluoroethyl sulfate, dichlorofluoroacetic acid, and inorganic fluoride. Metabolites of HCFC-132b were characterized as 2-chloro-2,2-difluoroethyl glucuronide, 2-chloro-2,2-difluoroethyl sulfate, chlorodifluoroacetic acid, chlorodifluoroacetaldehyde hydrate, chlorodifluoroacetaldehyde-urea adduct, and inorganic fluoride. HCFC-133a was metabolized to 2,2,2-trifluoroethyl glucuronide, trifluoroacetic acid, trifluoroacetaldehyde hydrate, trifluoroacetaldehyde-urea adduct, inorganic fluoride, and a minor, unidentified metabolite. With HCFC-131a and HCFC-132b, glucuronide conjugates of 2,2,2-trihaloethanols were the major urinary metabolites, whereas with HCFC-133a, a trifluoroacetaldehyde-urea adduct was the major urinary metabolite. Analysis of metabolite distribution in vivo indicated that aldehydic metabolites increased as fluorine substitution increased in the order HCFC-131a < HCFC-132b < HCFC-133a. With NADPH-fortified rat liver microsomes, HCFC-133a and HCFC-132b were biotransformed to trifluoroacetaldehyde and chlorodifluoroacetaldehyde, respectively, whereas HCFC-131a was converted to dichlorofluoroacetic acid. No covalently bound metabolites were detected by 19F NMR spectroscopy.(ABSTRACT TRUNCATED AT 250 WORDS)

  3. 26 CFR 1.72-1 - Introduction.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Introduction. 1.72-1 Section 1.72-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.72-1 Introduction. (a) General...

  4. 45 CFR 1220.1-1 - Introduction.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Introduction. 1220.1-1 Section 1220.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE PAYMENT OF VOLUNTEER LEGAL EXPENSES General § 1220.1-1 Introduction. Section 419 of the Domestic Volunteer...

  5. 26 CFR 1.545-1 - Definition.

    Science.gov (United States)

    2010-04-01

    ... TAXES (CONTINUED) Personal Holding Companies § 1.545-1 Definition. (a) Undistributed personal holding company income is the amount which is subject to the personal holding company tax imposed under section... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Definition. 1.545-1 Section 1.545-1 Internal...

  6. 26 CFR 1.556-1 - Definition.

    Science.gov (United States)

    2010-04-01

    ... TAXES (CONTINUED) Foreign Personal Holding Companies § 1.556-1 Definition. Undistributed foreign personal holding company income is the amount which is to be included in the gross income of the United... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Definition. 1.556-1 Section 1.556-1 Internal...

  7. 26 CFR 1.801-1 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... TAXES Life Insurance Companies § 1.801-1 Definitions. (a) Life insurance company. The term life.... For the definition of an “insurance company”, see paragraph (b) of this section. In determining... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Definitions. 1.801-1 Section 1.801-1 Internal...

  8. 26 CFR 1.165-1 - Losses.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Losses. 1.165-1 Section 1.165-1 Internal Revenue... (CONTINUED) Itemized Deductions for Individuals and Corporations § 1.165-1 Losses. (a) Allowance of deduction. Section 165(a) provides that, in computing taxable income under section 63, any loss actually sustained...

  9. Transportin-1-dependent YB-1 nuclear import

    International Nuclear Information System (INIS)

    Mordovkina, Daria A.; Kim, Ekaterina R.; Buldakov, Ilya A.; Sorokin, Alexey V.; Eliseeva, Irina A.; Lyabin, Dmitry N.; Ovchinnikov, Lev P.

    2016-01-01

    The DNA/RNA-binding protein YB-1 (Y-box binding protein 1) performs multiple functions both in the cytoplasm and the nucleus of the cell. Generally localized to the cytoplasm, under certain conditions YB-1 is translocated to the nucleus. Here we report for the first time a transport factor that mediates YB-1 nuclear import – transportin-1. The YB-1/transportin-1 complex can be isolated from HeLa cell extract. Nuclear import of YB-1 and its truncated form YB-1 (1-219) in in vitro transport assay was diminished in the presence of a competitor substrate and ceased in the presence of transportin-1 inhibitor M9M. Inhibitors of importin β1 had no effect on YB-1 transport. Furthermore, transport of YB-1 (P201A/Y202A) and YB-1 (1–219) (P201A/Y202A) bearing inactivating mutations in the transportin-1-dependent nuclear localization signal was practically abolished. Together, these results indicate that transportin-1 mediates YB-1 nuclear translocation. - Highlights: • Transportin-1 mediates YB-1 nuclear import. • YB-1 nuclear translocation is diminished in the presence of transportin-1 inhibitors. • Mutations in the PY motif of YB-1 NLS prevent its translocation to the nucleus.

  10. H1N1 influenza (Swine flu)

    Science.gov (United States)

    Swine flu; H1N1 type A influenza ... The H1N1 virus is now considered a regular flu virus. It is one of the three viruses included in the regular (seasonal) flu vaccine . You cannot get H1N1 flu virus from ...

  11. Carboxylesterase 1 genes

    DEFF Research Database (Denmark)

    Rasmussen, Henrik Berg; Madsen, Majbritt Busk

    2018-01-01

    The carboxylesterase 1 gene (CES1) encodes a hydrolase that metabolizes commonly used drugs. The CES1-related pseudogene, carboxylesterase 1 pseudogene 1 (CES1P1), has been implicated in gene exchange with CES1 and in the formation of hybrid genes including the carboxylesterase 1A2 gene (CES1A2...

  12. 1 CFR 5.1 - Publication policy.

    Science.gov (United States)

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication... Federal Register shall publish a serial publication called the Federal Register to contain the following...

  13. 1 CFR 9.1 - Publication required.

    Science.gov (United States)

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication required. 9.1 Section 9.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER THE UNITED STATES GOVERNMENT MANUAL § 9.1 Publication required. The Director of the Federal Register shall...

  14. 1 CFR 10.1 - Publication required.

    Science.gov (United States)

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special edition...

  15. 48 CFR 1.602-1 - Authority.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Authority. 1.602-1 Section... ACQUISITION REGULATIONS SYSTEM Career Development, Contracting Authority, and Responsibilities 1.602-1 Authority. (a) Contracting officers have authority to enter into, administer, or terminate contracts and...

  16. 16 CFR 1.1 - Policy.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Policy. 1.1 Section 1.1 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE GENERAL PROCEDURES Industry... substantial or novel question of fact or law and there is no clear Commission or court precedent; or (2) The...

  17. USEEIO v1.1 - Matrices

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset provides the basic building blocks for the USEEIO v1.1 model and life cycle results per $1 (2013 USD) demand for all goods and services in the model in...

  18. The analysis of the basketball coach speech during the moments of game and pause in relation to the performance in competition

    Directory of Open Access Journals (Sweden)

    Jorge Lorenzo

    2013-01-01

    Full Text Available En el ámbito de la competición deportiva profesional, el entrenador es una parte fundamental en la dirección de un equipo y más concretamente en la dirección de partido. Durante la competición, la gestión de los tiempos de pausa y tiempos muertos así como la conducta del entrenador durante los mismos es un aspecto a analizar en el rendimiento deportivo. Es por esto que se hace necesario conocer algunos de los comportamientos que resultan más frecuentes por parte de los entrenadores y que están más relacionados con un rendimiento positivo de sus jugadores. Para ello se ha realizado un estudio de 7 casos de entrenadores expertos en los que se ha observado su comportamiento verbal durante 4 partidos. Se ha centrado en el contenido de la información únicamente a nivel verbal, en su significado. Los datos que se han obtenido en el estudio muestran una mayor cantidad de información elaborada durante las pausas de los partidos y un mayor contenido táctico con respecto a los momentos de juego. Por otro lado, existe una relación entre un mayor número de preguntas y un menor número de instrucciones psicológicas cuando el marcador es adverso, mientras que en el caso de victoria, no existe una relación directa con ninguna categoría. El resto de categorías del discurso no se ven influenciadas directamente por el resultado, por lo que no se puede hablar de una relación directa e inmediata entre las conductas verbales del entrenador durante las pausas y el resultado del partido, salvo en momentos puntuales.

  19. Hyper-regulation of pyr-gene expression in Escherichia coli cells with slow ribosomes. Evidence for RNA polymerase pausing in vivo

    DEFF Research Database (Denmark)

    Jensen, Kaj Frank

    1988-01-01

    UTP-modulated attenuation of transcription is involved in regulating the synthesis of pyrimidine nucleotides in Escherichia coli. Thus, expression of two genes, pyrBI and pyrE, was shown to be under this type of control. The genes encode the two subunits of aspartate transcarbamylase and orotate...... transcription should terminate or continue into the structural genes. This paper described a study of pyrBI and pyrE gene regulation in cells where the ribosomes move slowly as a result of mutation in rpsL. It appears that expression of the two genes is hyper-regulated by the UTP pool in this type of cells...

  20. Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle

    DEFF Research Database (Denmark)

    Büchel, Gabriele; Carstensen, Anne; Mak, Ka-Yan

    2017-01-01

    MYC proteins bind globally to active promoters and promote transcriptional elongation by RNA polymerase II (Pol II). To identify effector proteins that mediate this function, we performed mass spectrometry on N-MYC complexes in neuroblastoma cells. The analysis shows that N-MYC forms complexes...

  1. Le détour, la pause et l'optimalité. Essai sur la distance et ses apports au transport et à l'urbanisme

    OpenAIRE

    L'HOSTIS, Alain

    2014-01-01

    La distance est un élément central pour la compréhension et pour l'action sur la ville et les territoires dans leurs liens avec les transports. Pourtant la distance n'a pas été considérée dans toutes ses potentialités dans les disciplines qui abordent la spatialité, c'est-à-dire la géographie, l'économie, la psychologie et la sociologie, et qui constituent les principaux gisements de savoirs académiques mobilisés par les spécialistes de l'urbanisme, de l'aménagement et des transports. L'inves...

  2. Le détour, la pause et l'optimalité, Essai sur la distance et ses apports au transport et à l'urbanisme

    OpenAIRE

    L'Hostis , Alain

    2014-01-01

    Distance is a central element in the understanding and for the action on cities, on territories and on transport. However, distance has not been considered at its full potential in the disciplines that care about spatiality, namely geography, economy, psychology and sociology, and that constitute the main corpus used by the specialists of urbanism, spatial planning and transport.The investigation exposed in this memoir shows that the geographical interpretation of the mathematical properties ...

  3. The chemistry of 1,1-dithiolates

    DEFF Research Database (Denmark)

    Henriksen, Lars; Autrup, Herman

    1970-01-01

    The reaction of dipotassium 2-nitroethylene-1,1-dithiolate (III) with α-halogeno aldehydes or ketones leads to derivatives of 3-nitro-thiophene-2-thiols. These reactions proceed by an acid catalyzed cyclization of the initially formed 1-(acylmethylthio)-2-nitroethylene-1-thiolates (IV). The infra...

  4. Smooth muscle fatigue due to repeated urinary bladder neurostimulation: an in vivo study.

    Science.gov (United States)

    Bross, S; Schumacher, S; Scheepe, J R; Seif, C; Jünemann, K P; Alken, P

    1999-01-01

    The presented study investigates the influence of different pause lengths between two consecutive stimulations of the S3 roots on intravesical pressure during bladder neurostimulation. In eight male foxhounds (aged 7-18 months), laminectomy and placement of a modified Brindley electrode were performed. In four series with different pause lengths between two consecutive stimulations (1, 3, 5, and 15 min), the maximum intravesical pressure was measured during stimulation. The changes in intravesical pressure were registered in these four series, each series with six stimulations. A 15-min interval elapsed before the commencement of each series. In the series with a pause length of 15 min, the consecutive stimulations did not result in significant changes in maximum intravesical pressure. In the 5-min series, a significant decrease in intravesical pressure was not observed after the third stimulation. In the 3-min series, a significant decrease was seen at almost every stimulation (average decrease of 3.8% per stimulation) and in the 1-min series, a significant decrease was also observed at almost every stimulation (average decrease of 5.9% per stimulation). The results of repeated bladder neurostimulation demonstrate that the maximum intravesical pressure is dependent on the pause length between two consecutive stimulations. The detrusor muscle showed reversible and short-lived signs of fatigue. This implies the importance of a minimum 5-min interval between two subsequent stimulations. A pause length <5 min leads to a falsification of the results and thus to lower validity of the investigation.

  5. The Escherichia coli Tus-Ter replication fork barrier causes site-specific DNA replication perturbation in yeast.

    Science.gov (United States)

    Larsen, Nicolai B; Sass, Ehud; Suski, Catherine; Mankouri, Hocine W; Hickson, Ian D

    2014-04-07

    Replication fork (RF) pausing occurs at both 'programmed' sites and non-physiological barriers (for example, DNA adducts). Programmed RF pausing is required for site-specific DNA replication termination in Escherichia coli, and this process requires the binding of the polar terminator protein, Tus, to specific DNA sequences called Ter. Here, we demonstrate that Tus-Ter modules also induce polar RF pausing when engineered into the Saccharomyces cerevisiae genome. This heterologous RF barrier is distinct from a number of previously characterized, protein-mediated, RF pause sites in yeast, as it is neither Tof1-dependent nor counteracted by the Rrm3 helicase. Although the yeast replisome can overcome RF pausing at Tus-Ter modules, this event triggers site-specific homologous recombination that requires the RecQ helicase, Sgs1, for its timely resolution. We propose that Tus-Ter can be utilized as a versatile, site-specific, heterologous DNA replication-perturbing system, with a variety of potential applications.

  6. Technetium (tin) ethane-1-hydroxy-1, 1-diphosphonate complexes

    International Nuclear Information System (INIS)

    Brand, J.A.G.M.

    1981-10-01

    The aim of this thesis is to establish the experimental conditions for the optimal preparation of the sup(99m)Tc(Sn)EHDP bone scanning agent. The pH and the concentrations of EHDP (ethane-1-hydroxy-1,1-disodium diphosphonate) and of Sn(II) may affect the yield and the biodistribution of the radiopharmacon. The investigation of the influence of these parameters is the subject of this investigation. (Auth.)

  7. The chemistry of 1,1-dithiolates

    DEFF Research Database (Denmark)

    Henriksen, L.; Autrup, Herman

    1972-01-01

    A series of thieno[3,2-e]-3,4-dihydro-1,2,3-triazin-4-ones (V) and thieno[3,4-e]-3,4-dihydro-1,2,3-triazin-4-ones (VI) were prepared by diazotation of 3-aminothiophene-2-carboxamides (III) and 4-amino-thiophene-3-carboxamides (IV), respectively, both obtained by cyclization of 2-cyanoethylene-1,1...

  8. Pandemic influenza A (H1N1)

    African Journals Online (AJOL)

    ... in Port Shepstone, South Africa. Introduction. Influenza A (H1N1) 2009 'swine flu' variant is currently a global pandemic.1 The infection associated with this virus is usually a mild, self-limiting illness. However, it may progress to severe pneumonia requiring intensive care unit (ICU) therapy in 31% of patients.2 This may.

  9. USEEIOv1.1 - openLCA

    Data.gov (United States)

    U.S. Environmental Protection Agency — This is a version of the full USEEIO v1.1 model in the openLCA schema serialized as JSON-LD that can be imported into openLCA software (www.openlca.org) v1.5 and...

  10. Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressants in Pregnancy and Congenital Anomalies

    DEFF Research Database (Denmark)

    Jordan, Sue; Morris, Joan K.; Davies, Gareth I.

    2016-01-01

    of LMP, separately and together, odds ratios with 95% confidence intervals (ORs, 95%CI) for all major anomalies were estimated. We also explored: pausing or discontinuing SSRIs preconception, confounding, high dose regimens, and, in Wales, diagnosis of depression. Results were combined in meta...... of anomalies and severe CHD was reduced when SSRI prescriptions were stopped or paused preconception, and increased when >1 prescription was recorded, but differences were not statistically significant. The dose-response relationship between severe CHD and SSRI dose (meta-regression OR 1.49, 1...... importance, justifying modifications to preconception care....

  11. Current Status of TRR-1/M1

    International Nuclear Information System (INIS)

    Sittichai, Chaiyut

    2000-01-01

    In 1961, the first Thai Research Reactor, TRR-1, having power of 1 MW was established. It was located at Office of Atomic Energy for Peace (OAEP) in Bangkok. TRR-1 was completely commissioned in June 1962. Plate typed high-enriched uranium (HEU) and U 3 O 8 -Al were used as fuel. Light water used as moderator and coolant. During 1975-1977, TRR-1 was shut down for modification. The reactor core and control system were disassembled and replaced by TRIGA Mark III. It is a circular hexagonal core typed reactor designed by General Atomics Company (GA). Afterwards, TRR-1 was officially renamed to Thai Research Reactor 1/Modification 1 (TRR-1/M1). TRR-1/M1 is a multipurpose reactor with nominal power of 2 MW. This swimming pool typed reactor uses low-enriched uranium (LEU) as fuel and light water as coolant and moderator. To date, the reactor has been operated with core No.12 that released power 1135 MWD to serve the user. The reactor has been serving for various kinds of utilization, for example, to produce radioisotope, neutron beam experiments and reactor physics experiments. This report explains in detail regarding operational experience and current status of this reactor, for example, reactor operation and reactor utilization. (author)

  12. Kinetics study of antimony adsorption on Si(1 1 1)

    International Nuclear Information System (INIS)

    Lapena, L.; Mueller, P.; Quentel, G.; Guesmi, H.; Treglia, G.

    2003-01-01

    In this paper, we use mass spectrometry (MS) and reflection high-energy electron (RHEED) to study the kinetics of adsorption of Sb on Si(1 1 1) surface and its relation to the corresponding surface structure. At high temperature (T>800 deg. C) all the impinging Sb 4 molecules completely dissociate at the silicon surface and a 2D gas of Sb monomers reversibly adsorbs on the (1x1) surface. At low temperature (T 4 molecules act as precursors and can be partially reflected or desorbed while a 2D stable layer of Sb monomers irreversibly adsorbs. The surface continuously shifts from a blurred (7x7) surface to a (1x1) structure near completion of the 2D layer. In the intermediate range (600 deg. C< T<800 deg. C) provided that the coverage is large enough (θ ∼ 2/3) the condensation of the 2D gas leads to a 2D (5√3 x 5√3) reconstruction. We show that introducing the formation of a condensed phase in a kinetics model allows us to reproduce our experimental data. Finally, we determine the adsorption geometry from ab initio calculations: Sb is adsorbed on top positions, somewhat passivating the Si surface dangling bonds

  13. PODAAC-DYNTO-1D1M1

    Data.gov (United States)

    National Aeronautics and Space Administration — The absolute dynamic topography data (similar to sea level but with respect to the geoid) are on monthly 1 degree grids. These data were generated to help support...

  14. Cloning and tissue expression of cytochrome P450 1B1 and 1C1 ...

    African Journals Online (AJOL)

    Cytochrome P450 1 (CYP1) is widely used as an indicator of exposure to environmental contaminants. In the study, two full-length complementary DNAs encode for CYP1B1 and CYP1C1 were cloned from medaka liver exposed to 500 ppb β-naphthoflavone for 24 h. CYP1B1, having 1984 bp, contains an open reading ...

  15. Density functional study of hypophosphite adsorption on Ni (1 1 1) and Cu (1 1 1) surfaces

    International Nuclear Information System (INIS)

    Zeng Yue; Liu Shubin; Ou Lihui; Yi Jianlong; Yu Shanci; Wang Huixian; Xiao Xiaoming

    2006-01-01

    Surface structures and electronic properties of hypophosphite, H 2 PO 2 - , molecularly adsorbed on Ni(1 1 1) and Cu(1 1 1) surfaces are investigated in this work by density functional theory at B3LYP/6-31++g(d, p) level. We employ a four-metal-atom cluster as the simplified model for the surface and have fully optimized the geometry and orientation of H 2 PO 2 - on the metal cluster. Six stable orientations have been discovered on both Ni (1 1 1) and Cu (1 1 1) surfaces. The most stable orientation of H 2 PO 2 - was found to have its two oxygen atoms interact the surface with two P-O bonds pointing downward. Results of the Mulliken population analysis showed that the back donation from 3d orbitals of the transition metal substrate to the unfilled 3d orbital of the phosphorus atom in H 2 PO 2 - and 4s orbital's acceptance of electron donation from one lone pair of the oxygen atom in H 2 PO 2 - play very important roles in the H 2 PO 2 - adsorption on the transition metals. The averaged electron configuration of Ni in Ni 4 cluster is 4s 0.63 4p 0.02 3d 9.35 and that of Cu in Cu 4 cluster is 4s 1.00 4p 0.03 3d 9.97 . Because of this subtle difference of electron configuration, the adsorption energy is larger on the Ni surface than on the Cu surface. The amount of charge transfers due to above two donations is larger from H 2 PO 2 - to the Ni surface than to the Cu surface, leading to a more positively charged P atom in Ni n H 2 PO 2 - than in Cu n H 2 PO 2 - . These results indicate that the phosphorus atom in Ni n H 2 PO 2 - complex is easier to be attacked by a nucleophile such as OH - and subsequent oxidation of H 2 PO 2 - can take place more favorably on Ni substrate than on Cu substrate

  16. 2+1 gravity for genus >1

    International Nuclear Information System (INIS)

    Nelson, J.E.; Regge, T.

    1991-01-01

    We analysed the algebra of observables for the simple case of a genus 1 initial data surface Σ 2 for 2+1 De Sitter gravity. Here we extend the analysis to higher genus. We construct for genus 2 the group of automorphisms H of the homotopy group π 1 induced by the mapping class group. The group H induces a group D of canonical transformations on the algebra of observables which is related to the braid group for 6 threads. (orig.)

  17. Verification report for SIMREP 1.1

    International Nuclear Information System (INIS)

    Tarapore, P.S.

    1987-06-01

    SIMREP 1.1 is a discrete event computer simulation of repository operations in the surface waste-handling facility. The logic for this model is provided by Fluor Technology, Inc., the Architect/Engineer of the salt repository. The verification methods included a line-by-line review of the code, a detailed examination of a generated trace of all simulated events over a given period of operations, and a comparison of the simulation output results with expected values. SIMREP 1.1 performs in the required manner under the given range of input conditions

  18. VANDAL user guide. V. 1.1

    International Nuclear Information System (INIS)

    Unsworth, M.D.

    1989-02-01

    This document forms Volume 1.1 of the VANDAL User Guide and is intended to provide all the information necessary to define and run a case study. Information is given on the data to be specified, on the structure of the input data files and on how to execute the system. There are three related volumes to this, they are: Volume 1.2 - Input and Execution Appendices; Volume 2.1 - Ouput and Error Messages; and Volume 2.2 - PRA Output Analysis. (author)

  19. Chemical and electrical passivation of Si(1 1 1) surfaces

    International Nuclear Information System (INIS)

    Tian Fangyuan; Yang Dan; Opila, Robert L.; Teplyakov, Andrew V.

    2012-01-01

    This paper compares the physical and chemical properties of hydrogen-passivated Si(1 1 1) single crystalline surfaces prepared by two main chemical preparation procedures. The modified RCA cleaning is commonly used to prepare atomically flat stable surfaces that are easily identifiable spectroscopically and are the standard for chemical functionalization of silicon. On the other hand electronic properties of these surfaces are sometimes difficult to control. A much simpler silicon surface preparation procedure includes HF dipping for a short period of time. This procedure yields an atomically rough surface, whose chemical identity is not well-defined. However, the surfaces prepared by this approach often exhibit exceptionally attractive electronic properties as determined by long charge carrier lifetimes. This work utilizes infrared spectroscopy and X-ray photoelectron spectroscopy to investigate chemical modification of the surfaces prepared by these two different procedures with PCl 5 (leading to surface chlorination) and with short- and long-alkyl-chain alkenes (1-decene and 1-octodecene, respectively) and follows the electronic properties of the starting surfaces produced by measuring charge-carrier lifetimes.

  20. Chemical and electrical passivation of Si(1 1 1) surfaces

    Science.gov (United States)

    Tian, Fangyuan; Yang, Dan; Opila, Robert L.; Teplyakov, Andrew V.

    2012-01-01

    This paper compares the physical and chemical properties of hydrogen-passivated Si(1 1 1) single crystalline surfaces prepared by two main chemical preparation procedures. The modified RCA cleaning is commonly used to prepare atomically flat stable surfaces that are easily identifiable spectroscopically and are the standard for chemical functionalization of silicon. On the other hand electronic properties of these surfaces are sometimes difficult to control. A much simpler silicon surface preparation procedure includes HF dipping for a short period of time. This procedure yields an atomically rough surface, whose chemical identity is not well-defined. However, the surfaces prepared by this approach often exhibit exceptionally attractive electronic properties as determined by long charge carrier lifetimes. This work utilizes infrared spectroscopy and X-ray photoelectron spectroscopy to investigate chemical modification of the surfaces prepared by these two different procedures with PCl5 (leading to surface chlorination) and with short- and long-alkyl-chain alkenes (1-decene and 1-octodecene, respectively) and follows the electronic properties of the starting surfaces produced by measuring charge-carrier lifetimes.

  1. 26 CFR 303.1-1 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... TAXES UNDER THE TRADING WITH THE ENEMY ACT § 303.1-1 Definitions. (a) General. When used in this part... vested property or liable or charged with liability for internal revenue tax in connection with such... successor in interest by inheritance, devise, bequest, or operation of law, of such owner. (f) Trading With...

  2. Ciencias 1. (Science 1). [Student's Workbook].

    Science.gov (United States)

    Raposo, Lucilia

    Ciencias 1 is the first in a series of science books designed for elementary Portuguese-speaking students. The book contains five sections divided into 43 lessons. The five sections are (1) Matter, (2) The Human Body, (3) Weather, (4) Solids, Liquids, and Gases, and (5) Living Things. Pictorial presentations and picture exercises are included for…

  3. Release Notes for Whisper-1.1

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Forrest B. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rising, Michael Evan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Alwin, Jennifer Louise [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-04-27

    Whisper is a statistical analysis package developed in 2014 to support nuclear criticality safety (NCS) validation [1-3]. It uses the sensitivity profile data for an application as computed by MCNP6 [4-6] along with covariance files [7,8] for the nuclear data to determine a baseline upper-subcritical-limit (USL) for the application. Whisper version 1.0 was first developed and used at LANL in 2014 [3]. During 2015-2016, Whisper was updated to version 1.1 [9] and is to be included with the upcoming release of MCNP6.2. This document describes the Whisper-1.1 package that will be included with the MCNP6.2 release during 2017. Specific details are provided on the computer systems supported, the software quality assurance (SQA) procedures, installation, and testing. This document does not address other important topics, such as the importance of sensitivity-uncertainty (SU) methods to NCS validation, the theory underlying SU methodology, tutorials on the usage of MCNP-Whisper, practical approaches to using SU methodology to support and extend traditional validation, etc. There are over 50 documents included with Whisper-1.1 and available in the MCNP Reference Collection on the MCNP website (mcnp.lanl.gov) that address all of those topics and more. In this document, however, a complete bibliography of relevant MCNP-Whisper references is provided.

  4. Antiviral Prophylaxis and H1N1

    Centers for Disease Control (CDC) Podcasts

    2011-07-14

    Dr. Richard Pebody, a consultant epidemiologist at the Health Protection Agency in London, UK, discusses the use of antiviral post-exposure prophylaxis and pandemic H1N1.  Created: 7/14/2011 by National Center for Emerging Zoonotic and Infectious Diseases (NCEZID).   Date Released: 7/18/2011.

  5. 26 CFR 302.1-1 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... TAXES UNDER THE INTERNATIONAL CLAIMS SETTLEMENT ACT, AS AMENDED AUGUST 9, 1955 § 302.1-1 Definitions. (a...” includes the officer in whom property is vested pursuant to title II of the International Claims Settlement... claiming an interest in vested property or liable or charged with liability for internal revenue tax in...

  6. 26 CFR 1.535-1 - Definition.

    Science.gov (United States)

    2010-04-01

    ... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Corporations Used to Avoid Income Tax on Shareholders § 1.535-1 Definition. (a) The accumulated earnings tax is imposed by section 531 on the accumulated taxable income. Accumulated taxable...

  7. 26 CFR 1.150-1 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... is the purpose investment). (B) Recycling of certain payments under purpose investments. A conduit... for all purposes of sections 103 and 141 through 150. (2) Effective date—(i) In general. Except as... obligor on a purpose investment (as defined in § 1.148-1). For example, if an issuer invests proceeds in a...

  8. General Relativity in (1 + 1) Dimensions

    Science.gov (United States)

    Boozer, A. D.

    2008-01-01

    We describe a theory of gravity in (1 + 1) dimensions that can be thought of as a toy model of general relativity. The theory should be a useful pedagogical tool, because it is mathematically much simpler than general relativity but shares much of the same conceptual structure; in particular, it gives a simple illustration of how gravity arises…

  9. Investigation of the pulsed electrochemical deposition of ZnO

    International Nuclear Information System (INIS)

    Dunkel, Christian; Lüttich, Franziska; Graaf, Harald; Oekermann, Torsten; Wark, Michael

    2012-01-01

    The influence of pulse parameters on the morphology of ZnO prepared by pulsed cathodic electrodeposition from oxygen-saturated aqueous ZnCl 2 solution on ITO (indium tin oxide)/glass substrates was investigated. It was found that the ratio between the pulse and the pause duration has a crucial influence on the crystal growth, reaching the highest density of the films with pause/pulse-ratios between 0.25 and 1. Longer pauses cause an Ostwald-like ripening of the ZnO crystals and therewith a strong change in the crystal morphology from roundly shaped to hexagonal. Also the hydrophilicity of the substrate resulting from pre-treatment has a crucial influence on the deposited films, leading to films only consisting of few large and separately grown ZnO crystals for highly hydrophilic substrates and an increasing fraction of small densely grown ZnO crystals with increasing hydrophobicity.

  10. 1-Methoxy-1,1-diphenylbut-2-yne

    Directory of Open Access Journals (Sweden)

    Nadine Seidel

    2018-04-01

    Full Text Available In the title compound, C17H16O, the phenyl rings are twisted relative to each other at an angle of 85.9 (1°. The crystal structure features weak C—H...π interactions, which connect the molecules into a three-dimensional supramolecular network.

  11. Type 1 Diabetes Facts

    Science.gov (United States)

    ... Affiliates JDRF Celebrity Ambassadors JDRF Logo Usage Contact Us Donate Events More Type 1 Diabetes Facts Type 1 diabetes (T1D) is an autoimmune ... about Insulin and T1D Learn More What Is Diabetes? Causes of T1D The Complexity of Diagnosing ... US CAREERS NEWSROOM FOR RESEARCHERS © JDRF 2018 • Privacy Policy • ...

  12. PODAAC-QSNON-L1CA1

    Data.gov (United States)

    National Aeronautics and Space Administration — This dataset contains geo-located and averaged Level 1B Sigma-0 measurements and wind retrievals from the SeaWinds on QuikSCAT platform, initiated in the months...

  13. Theophylline–gentisic acid (1/1

    Directory of Open Access Journals (Sweden)

    Srinivasulu Aitipamula

    2009-09-01

    Full Text Available In the title 1:1 cocrystal, C7H8N4O2·C7H6O4, the anti-asthmatic drug theophylline (systematic name: 1,3-dimethyl-7H-purine-2,6-dione and a non-steroidal anti-inflammatory drug, gentisic acid (systematic name: 2,5-dihydroxybenzoic acid crystallize together, forming two-dimensional hydrogen-bonded sheets involving N—H...O and O—H...N hydrogen bonds. The overall crystal packing features π–π stacking interactions [centroid–centroid distance = 3.348 (1 Å]. The cocrystal described herein belongs to the class of pharmaceutical cocrystals involving two active pharmaceutical ingredients which has been relatively unexplored to date.

  14. G1SST, 1km blended SST

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A daily, global Sea Surface Temperature (SST) data set is produced at 1-km (also known as ultra-high resolution) by the JPL ROMS (Regional Ocean Modeling System)...

  15. Type 1 diabetes

    Science.gov (United States)

    Insulin-dependent diabetes; Juvenile onset diabetes; Diabetes - type 1; High blood sugar - type 1 diabetes ... Type 1 diabetes can occur at any age. It is most often diagnosed in children, adolescents, or young adults. Insulin is ...

  16. Prism. Volume 1, Number 1, December 2009

    Science.gov (United States)

    2009-12-01

    strategy, regional security affairs, and global strategic problems. This is the authoritative , official U.S. Department of Defense edition of PRISM...suffer from illiteracy, poor health, and extreme poverty PRISM 1, no. 1 FRoM the FIeld | 89 The country’s maternal mortality and female illiteracy rates...problems. This is the authoritative , official U.S. Department of Defense edition of PRISM. Any copyrighted portions of this journal may not be

  17. SPARK Version 1.1 user manual

    International Nuclear Information System (INIS)

    Weissenburger, D.W.

    1988-01-01

    This manual describes the input required to use Version 1.1 of the SPARK computer code. SPARK 1.1 is a library of FORTRAN main programs and subprograms designed to calculate eddy currents on conducting surfaces where current flow is assumed zero in the direction normal to the surface. Surfaces are modeled with triangular and/or quadrilateral elements. Lorentz forces produced by the interaction of eddy currents with background magnetic fields can be output at element nodes in a form compatible with most structural analysis codes. In addition, magnetic fields due to eddy currents can be determined at points off the surface. Version 1.1 features eddy current streamline plotting with optional hidden-surface-removal graphics and topological enhancements that allow essentially any orientable surface to be modeled. SPARK also has extensive symmetry specification options. In order to make the manual as self-contained as possible, six appendices are included that present summaries of the symmetry options, topological options, coil options and code algorithms, with input and output examples. An edition of SPARK 1.1 is available on the Cray computers at the National Magnetic Fusion Energy Computer Center at Livermore, California. Another more generic edition is operational on the VAX computers at the Princeton Plasma Physics Laboratory and is available on magnetic tape by request. The generic edition requires either the GKS or PLOT10 graphics package and the IMSL or NAG mathematical package. Requests from outside the United States will be subject to applicable federal regulations regarding dissemination of computer programs. 22 refs

  18. SPARK Version 1. 1 user manual

    Energy Technology Data Exchange (ETDEWEB)

    Weissenburger, D.W.

    1988-01-01

    This manual describes the input required to use Version 1.1 of the SPARK computer code. SPARK 1.1 is a library of FORTRAN main programs and subprograms designed to calculate eddy currents on conducting surfaces where current flow is assumed zero in the direction normal to the surface. Surfaces are modeled with triangular and/or quadrilateral elements. Lorentz forces produced by the interaction of eddy currents with background magnetic fields can be output at element nodes in a form compatible with most structural analysis codes. In addition, magnetic fields due to eddy currents can be determined at points off the surface. Version 1.1 features eddy current streamline plotting with optional hidden-surface-removal graphics and topological enhancements that allow essentially any orientable surface to be modeled. SPARK also has extensive symmetry specification options. In order to make the manual as self-contained as possible, six appendices are included that present summaries of the symmetry options, topological options, coil options and code algorithms, with input and output examples. An edition of SPARK 1.1 is available on the Cray computers at the National Magnetic Fusion Energy Computer Center at Livermore, California. Another more generic edition is operational on the VAX computers at the Princeton Plasma Physics Laboratory and is available on magnetic tape by request. The generic edition requires either the GKS or PLOT10 graphics package and the IMSL or NAG mathematical package. Requests from outside the United States will be subject to applicable federal regulations regarding dissemination of computer programs. 22 refs.

  19. User Manual for Whisper-1.1

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Forrest B. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rising, Michael Evan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Alwin, Jennifer Louise [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-01-26

    Whisper is a statistical analysis package developed in 2014 to support nuclear criticality safety (NCS) validation [1-3]. It uses the sensitivity profile data for an application as computed by MCNP6 [4-6] along with covariance files [7,8] for the nuclear data to determine a baseline upper-subcritical-limit (USL) for the application. Whisper version 1.0 was first developed and used at LANL in 2014 [3]. During 2015- 2016, Whisper was updated to version 1.1 and is to be included with the upcoming release of MCNP6.2. This document describes the user input and options for running whisper-1.1, including 2 perl utility scripts that simplify ordinary NCS work, whisper_mcnp.pl and whisper_usl.pl. For many detailed references on the theory, applications, nuclear data & covariances, SQA, verification-validation, adjointbased methods for sensitivity-uncertainty analysis, and more – see the Whisper – NCS Validation section of the MCNP Reference Collection at mcnp.lanl.gov. There are currently over 50 Whisper reference documents available.

  20. User Manual for Whisper-1.1

    International Nuclear Information System (INIS)

    Brown, Forrest B.; Rising, Michael Evan; Alwin, Jennifer Louise

    2017-01-01

    Whisper is a statistical analysis package developed in 2014 to support nuclear criticality safety (NCS) validation [1-3]. It uses the sensitivity profile data for an application as computed by MCNP6 [4-6] along with covariance files [7,8] for the nuclear data to determine a baseline upper-subcritical-limit (USL) for the application. Whisper version 1.0 was first developed and used at LANL in 2014 [3]. During 2015- 2016, Whisper was updated to version 1.1 and is to be included with the upcoming release of MCNP6.2. This document describes the user input and options for running whisper-1.1, including 2 perl utility scripts that simplify ordinary NCS work, whisper_mcnp.pl and whisper_usl.pl. For many detailed references on the theory, applications, nuclear data & covariances, SQA, verification-validation, adjointbased methods for sensitivity-uncertainty analysis, and more - see the Whisper - NCS Validation section of the MCNP Reference Collection at mcnp.lanl.gov. There are currently over 50 Whisper reference documents available.

  1. Boes Skov 1 Udgravningsberetning

    DEFF Research Database (Denmark)

    Løvschal, Mette; Søndergaard, Louise; Vinter, Michael

    2018-01-01

    . Aktivitetsområdet rummer flere keramikrige gruber, ildsteder samt en kogestensgrube. På baggrund af keramikken kan oldtidsagrene og grubekomplekset dateres til omtrent den samme periode: yngre bronzealder-førromersk jernalder med en koncentration i førromersk jernalder periode 1. Aktivitetsområdet er tegnet i 1......:10 til 1:50, oversigtskortene er 1:75 til 1:250 og enkelte øvrige anlæg er tegnet i 1:20....

  2. Reinforcement of drinking by running: effect of fixed ratio and reinforcement time1

    Science.gov (United States)

    Premack, David; Schaeffer, Robert W.; Hundt, Alan

    1964-01-01

    Rats were required to complete varying numbers of licks (FR), ranging from 10 to 300, in order to free an activity wheel for predetermined times (CT) ranging from 2 to 20 sec. The reinforcement of drinking by running was shown both by an increased frequency of licking, and by changes in length of the burst of licking relative to operant-level burst length. In log-log coordinates, instrumental licking tended to be a linear increasing function of FR for the range tested, a linear decreasing function of CT for the range tested. Pause time was implicated in both of the above relations, being a generally increasing function of both FR and CT. PMID:14120150

  3. Process and device for change of catalyst in tube reactors

    International Nuclear Information System (INIS)

    Fedders, H.; Cremer, P.; Erben, R.

    1985-01-01

    The change of catalyst in narrow reactor tubes with a height: diameter ratio of at least 30:1 is done by the catalyst filling being driven out against the force of gravity using a pulsating liquid flow. Pauses in the flow of between 0.1 to 1 sec between flow periods of 2 to 20 secs are useful. (orig./PW) [de

  4. Determination of taste receptor type 1 member 1 (TAS1R1) gene ...

    African Journals Online (AJOL)

    Jane

    2011-10-10

    Oct 10, 2011 ... 1Institute of Cellular and Molecular Biology, College of Life Science, Xuzhou Normal University, ... TAS1R1 and TAS1R3 form an L-amino acid sensor, ... 0.5 × TBE buffer (89 mM tris–borate, 2 mM EDTA, pH 8.3) for 2 h at.

  5. Cardiomyopathy from 1,1-Difluoroethane Inhalation.

    Science.gov (United States)

    Kumar, Suwen; Joginpally, Tejaswini; Kim, David; Yadava, Mrinal; Norgais, Konchok; Laird-Fick, Heather S

    2016-10-01

    Consumer aerosol products can be inhaled for their psychoactive effects, but with attendant adverse health effects including "sudden sniffing death." Cardiomyopathy has rarely been described in association with 1,1-difluoroethane (DFE), a common aerosol propellant. We report a 33-year-old male who developed acute myocardial injury and global hypokinesis along with rhabdomyolysis, acute kidney injury, and fulminant hepatitis after 2 days' nearly continuous huffing. Workup for other causes, including underlying coronary artery disease, was negative. His cardiac function improved over time. The exact mechanism of DFE's effects is uncertain but may include catecholamine-induced cardiomyopathy, coronary vasospasm, or direct cellular toxicity.

  6. Rwanda Journal - Vol 1, No 1 (2016)

    African Journals Online (AJOL)

    Investigation of quasi periodic signals of X-Ray bursts from neutron star AXP 1E2259+586 using Fourier analysis techniques · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. S Ally, N.T. Jiwaji ...

  7. 8 CFR 1.1 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... prior to March 1, 2003. Unless otherwise specified, references after that date mean the Director of the... Service forms by one whose remuneration, if any, is nominal and who does not hold himself out as qualified... Office means Executive Office for Immigration Review. (o) The terms director or district director prior...

  8. 1-[1-(4-Nitrophenylethylidene]thiosemicarbazide

    Directory of Open Access Journals (Sweden)

    Yu-Feng Ding

    2008-09-01

    Full Text Available The title compound, C9H10N4O2S, was prepared by the reaction of 1-(4-nitrophenylethanone and thiosemicarbazide in ethanol at 367 K. There are weak intermolecular N—H...S and N—H...O hydrogen-bonding interactions in the crystal structure involving the amine and nitrile groups, respectively, as donors.

  9. 44 CFR 1.1 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... Manual No. 1140.1, “The Formulation, Drafting, Clearance, and Publication of Federal Register Documents... and procedures incorporate those provisions of section 4 of the Administrative Procedure Act (APA) (5 U.S.C. 553) which FEMA will follow. This part and internal FEMA Manuals implement Executive Order...

  10. Mizan 1.1, post-print

    African Journals Online (AJOL)

    eliasn

    B, LL.M, Lecturer in Law, St. Mary's. University College. 1 “The Law of Lagos” Resolution in M. Hamalengwa and others (eds) The ..... would mean that the Court would lose its independence from the AU and possible from the political concerns ...

  11. 26 CFR 1.6001-1 - Records.

    Science.gov (United States)

    2010-04-01

    ... substantiation of traveling and other business expenses of employees, see § 1.162-17. (c) Exempt organizations... business of farming, and individuals whose gross income includes salaries, wages, or similar compensation... respect to the tax imposed by section 511 on unrelated business income of certain exempt organizations...

  12. Annual report 2002. 1.1.-21.1.2002

    International Nuclear Information System (INIS)

    Pillar, V.

    2003-01-01

    In this Annual report of the Slovak Electric, plc (Slovenske elektrarne, a.s.) the results of operation in 2002 for the period from January 1 to January 21 are presented. It is unusual for a year to be considered as a matter of a few days, however, this is the case given the events at Slovak Electric, joint stock company which as of 21. 1. 2002 was dissolved and from which three new joint stock companies were established. Further proof of this is the annual report for 2002, which details the economic performance of the company during these 21 days, and the quantity of electricity and heat it generated and supplied to consumers. I am pleased to be able to state that this period of far-reaching changes during which the division of Slovak Electric, joint stock company into the new Slovak Electric, joint stock company, Slovak Electricity Transmission System, joint stock company and Heat Plant Kosice, joint stock company took place, did not cause any problems for Slovak consumers of electricity and heat. During the mentioned 21 January days of 2002, the sources of Slovak Electric generated 836,751 MWh of electricity, which represents 107 percent of the planned generation. The net profit for this period was 742,920 thousand crowns, the main influence being, of course, its short duration. As our economists have confirmed, the most important fact with a significant impact on net profit can be considered to be the amount of deferred taxes, which totalled 1,026,789 thou. Sk. With respect to the dissolution of the company, the company will apply 50 % tax depreciation from annual depreciation, which will, however, be reflected in the results of the newly established company - SE, a.s., as in the subsequent 344 day period its tax deductible depreciation will fall. It is clear that in the forthcoming period, in addition to this, many financial issues remain to be resolved by the management connected with the new form of the business, price, and management relationships within

  13. CYP1A1, CYP1A2, SULT1A1 AND SULT1E1 ALLELIC POLYMORPHISM IN CASE OF GENITAL ENDOMETRIOSIS

    Directory of Open Access Journals (Sweden)

    Konstantin Sergeevich Kublinskiy

    2016-02-01

    Up-to-date molecular and genetic analyses reveal that women predisposed to genital endometriosis possess Allele G and Genotypes AG and GG of the polymorphic option A-4889G of the CYP1A1 gene and Allele A and Genotypes CA and AA of the polymorphic option C-734A of the CYP1A2 gene. The polymorphism of the promoter regions of the SULT1A1 (G-638A and SULT1E1 (C-174T genes is not associated with genital endometriosis in women.

  14. 6,6'-(1E,1'E-((1R,2R-1,2-Diphenylethane-1,2-diylbis(azan-1-yl-1-ylidenebis(methan-1-yl-1-ylidenebis(2-tert-butyl-4-((trimethylsilylethynylphenol

    Directory of Open Access Journals (Sweden)

    David Díaz Díaz

    2013-03-01

    Full Text Available Functionalizable salen derivative, 6,6'-(1E,1'E-((1R,2R-1,2-diphenylethane-1,2-diylbis(azan-1-yl-1-ylidenebis(methan-1-yl-1-ylidenebis(2-tert-butyl-4-((trimethylsilyl ethyn-ylphenol (3, was synthesized by condensation between (1R,2R-1,2-diphenylethane-1,2-diamine (2 and 3-tert-butyl-2-hydroxy-5-((trimethylsilylethynyl benzaldehyde (1 under refluxing conditions. The title compound was characterized by 1H-NMR, 13C-NMR, FT-IR, high-resolution mass spectrometry, optical rotation and melting point determination.

  15. Computation of principal stresses and stress intensity of a nozzle on a spherical pressure vessel

    International Nuclear Information System (INIS)

    Sun, B.C.; Lyow, B.L.; Koplik, B.

    1993-01-01

    This paper presents a Stress Computation Table that systematically computes the local stresses at various locations of the sphere-nozzle intersection. The six components of external loading are: radial load, two overturning moments, two horizontal shear forces, and a torsional moment. The radial and overturning moments induce local membrane and bending stresses in both the circumferential and meridional directions of the sphere around the nozzle. The shear forces and torsional moment produce local shear stresses. In addition, the shear forces induce local membrane and bending stresses around the nozzle. The local stress factors from each external loading component are taken from recent publications by Lyow, Sun and Koplik who have studied this subject through the use of the finite element method. These factors are a function of the nozzle-sphere geometrical parameters, beta, β, (nozzle radius/sphere radius) and gamma, γ, (sphere radius/thickness), with the beta value ranging from 0.1 to 0.5, and the gamma value ranging from 10 to 100. The Stress Table summarizes all the normal and shear stresses at eight different locations around the nozzle, and finally the principal stresses and stress intensity are computed. The stress factor plots from previous publications are replotted in this paper to provide a handy reference as well as consistency. A numerical sample employing a FORTRAN program is also given. (author)

  16. Critical N = (1, 1) general massive supergravity

    Science.gov (United States)

    Deger, Nihat Sadik; Moutsopoulos, George; Rosseel, Jan

    2018-04-01

    In this paper we study the supermultiplet structure of N = (1, 1) General Massive Supergravity at non-critical and critical points of its parameter space. To do this, we first linearize the theory around its maximally supersymmetric AdS3 vacuum and obtain the full linearized Lagrangian including fermionic terms. At generic values, linearized modes can be organized as two massless and 2 massive multiplets where supersymmetry relates them in the standard way. At critical points logarithmic modes appear and we find that in three of such points some of the supersymmetry transformations are non-invertible in logarithmic multiplets. However, in the fourth critical point, there is a massive logarithmic multiplet with invertible supersymmetry transformations.

  17. ORCID implementation in Invenio 1.1

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    We present an extension to the Invenio 1.1 software for semi-automatically harvesting ORCID IDs of users and allowing them to upload publications to their respective ORCID profile. This extension was created in the context of the Join2 initiative, however, it can easily be adapted to other Invenio instances because it is only loosely coupled with Invenio itself. It opens its own local webserver to handle the additional endpoints, and calls Invenio API functions and command line programs to interact with the database. We also present a recommended workflow for successfully harvesting ORCID ID in an institution. The implementation is realised in well-documented Python 2.6 and Go and will be published as Free Software.

  18. Test OPTRAN 1-1 results

    International Nuclear Information System (INIS)

    Martinson, Z.R.

    1982-01-01

    The objective of the OPT 1-1 Test Series was to evaluate the extent of damage and the threshold for failure during simulated BWR anticipated transients. Four power transient tests with progressively higher power levels were performed with preirradiated fuel rods at power ramp rates as high as 550 kW/m per second. Six separately shrouded fuel rods fabricated by the General Electric Co., and preirradiated in the Monticello BWR to burnups of about 5000 to 23,000 MWd/t were tested, four at a time. Four of the fuel rods were of typical GE 8 x 8 design, except for fuel length (0.75 m). Two of the rods included design modifications to improve their PCI-resistant characteristics. A lengthy fuel conditioning preceded the transient testing of the fuel rods

  19. Main: 1FK1 [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available Molecule: Non-Specific Lipid Transfer Protein; Chain: A Lipid Transport G.W.Han, J.Y.Lee, H.K.Song, D.H.Shin....Kim, J.Choe, D.Lim, H.J.Moon, S.W.Suh Structural Basis Of Non-Specific Lipid Binding In Mai...y; @=28-120.|PDB; 1MZM; X-ray; @=28-120.|MaizeDB; 25447; -.|InterPro; IPR003612;

  20. CO adsorption on PdGa(1 0 0), (1 1 1) and (1{sup ¯}1{sup ¯}1{sup ¯}) surfaces: A DFT study

    Energy Technology Data Exchange (ETDEWEB)

    Bechthold, P.; Ardhengi, J.S.; Juan, A., E-mail: cajuan@uns.edu.ar; González, E.A.; Jasen, P.V.

    2014-10-01

    Graphical abstract: - Highlights: • CO adsorption is top on Pd sites for all surfaces. • Our results agree with TDS peak at 210 K for PdGa (1{sup ¯}1{sup ¯}1{sup ¯}) attributed to CO-Pd bond. • Pd-CO bond is formed at expenses of metal-metal bond. No Ga-CO interaction is found. • A back-donation for all surfaces was detected. After adsorption Pd PDOS shift towards lower energies. • IR frequencies for the C-O adsorbed presents a red shift compared to gas phase. - Abstract: CO adsorption on (1 0 0), (1 1 1) and (1{sup ¯}1{sup ¯}1{sup ¯}) planes is analyzed using density functional theory (DFT) calculations. Changes in the electronic structure of these surfaces and CO bond after adsorption are also addressed here. CO is located on Pd atop geometry with a tilted configuration of 7.8° in the (1 0 0) plane, while in the (1 1 1) and (1{sup ¯}1{sup ¯}1{sup ¯}) are perpendicular to the surface. No direct interaction of CO with Ga is detected. The overlap population (OP) of Pd-Pd and Pd-Ga bond decreases as the new Pd-CO bond is formed. In all cases, the C-O bond length changes less than 1% compared to the vacuum but its strength decrease about 50% as determined by the changes in the OP. The effect of CO is limited to its first Pd neighbor. Analysis of orbital interaction reveals that Pd-CO bond mainly involves s-s and s-p orbitals with less participation of Pd 4d orbitals. Computed CO vibration frequencies after adsorption shows a red shift from vacuum towards 1972.9, 1990.4 and 1988.6 cm{sup −1} on (1 0 0), (1 1 1) and (1{sup ¯}1{sup ¯}1{sup ¯}) planes respectively, following the same trend that experimental data on the PdGa intermetallic compound.

  1. Vitamin B1

    Science.gov (United States)

    ... Prize Alfred Nobel's Life and Work Teachers' Questionnaire Vitamin B1 - About The Chicken Farm educational game and ... the game window. Reading: "Christian Eijkman, Beriberi and Vitamin B1" - Who was Eijkman and why did he ...

  2. Adisa & Adekoya (1)

    African Journals Online (AJOL)

    USER

    Ife Journal of Science vol. 18, no. 1 (2016) ... 1 Department of Applied Geology, Federal University of Technology Akure, Nigeria. 2 Department of .... Adisa and Adekoya: Statistical Analysis of Stream Sediment Geochemical Data. 40. 40. ' 5 0.

  3. Melaminium nitrate–melamine–water (1/1/1

    Directory of Open Access Journals (Sweden)

    Farook Adam

    2010-11-01

    Full Text Available In the crystal structure of the title salt, C3H7N6+·NO3−·C3H6N6·H2O, the asymmetric unit consists of two neutral melamine (1,3,5-triazine-2,4,6-triamine molecules, two melaminium cations, two nitrate anions and two solvent water molecules. One of the nitrate anions is disordered over two sets of positions, with a refined occupancy ratio of 0.909 (3:0.091 (3. The cations and neutral molecules are approximately planar, with maximum deviations of 0.018 (2, 0.024 (2, 0.019 (2 and 0.007 (2 Å for each, respectively. In the crystal structure, melaminium cations and netural melamine molecules self-assemble via N—H...N hydrogen bonds to form a supramolecular hexagonal-shaped motif. In addition, the nitrate anions and water molecules are connected by N—H...O hydrogen bonds to form a three-dimensional network.

  4. Diabetes, Type 1

    OpenAIRE

    Riazi, Afsane; Bradley, Clare

    2007-01-01

    This chapter provides an overview of the role of psychological stress in Type 1 diabetes. Studies relating to stress and Type 1 diabetes onset and control, as well as the evidence relating to stress management training in people with Type 1 diabetes are discussed.

  5. Preparation of 1-bromoheptacosane

    International Nuclear Information System (INIS)

    Hernandez, L.; Hernandez, A.; Gonzalez, J.C.

    1996-01-01

    Alkybromides are ones of the main organic precursors for fatty acids and alcohols labelling with Carbon 1-14. In this work the preparation of 1-bromoheptacosane by bromodescarboxylation of 1-octacosanoic acid is described. The synthesis yielded 80.5% of final product and more than 97% of chemical purity. Clean-up procedure modifications and spectral data bromoheptacosane are also reported

  6. The First Digit 1

    Indian Academy of Sciences (India)

    IAS Admin

    1075. RESONANCE | December 2013. GENERAL | ARTICLE. Table 2. The first digits distri- bution according to Benford's law. First Frequency. Digit. 1. 30.1 %. 2. 17.6 %. 3. 12.4 %. 4. 9.7 %. 5. 7.9 %. 6. 6.7 %. 7. 5.8 %. 8. 5.1 %. 9. 4.5 % ...

  7. Porcine SLITRK1

    DEFF Research Database (Denmark)

    Larsen, Knud Erik; Momeni, Jamal; Farajzadeh, Leila

    2014-01-01

    The membrane protein SLITRK1 functions as a developmentally regulated stimulator of neurite outgrowth and variants in this gene have been implicated in Tourette syndrome. In the current study we have cloned and characterized the porcine SLITRK1 gene. The genomic organization of SLITRK1 lacks...

  8. supp1.doc

    Indian Academy of Sciences (India)

    hexa decane]-2'(7'),4',6',8'-tetraene-2,5,13',15'-tetrone (cis-3a). Pale pink solid, mp: 118-120 oC; Rf = 0.23 (60% ethylacetate: petroleum ether); IR (KBr): 1196, 1352, 1715, 2961, 3235 cm-1; 1H NMR (500 MHz, CDCl3): δ 2.86 (d, 1H, J = 18.3 ...

  9. On the 1-nucleolus

    OpenAIRE

    Estévez-Fernández, M.A.; Borm, Peter; Fiestras; Mosquera; Sanchez

    2017-01-01

    This paper analyzes the 1-nucleolus and, in particular, its relation to the nucleolus. It is seen that, contrary to the nucleolus, the 1-nucleolus can be computed in polynomial time due to a characterization using a combination of standard bankruptcy rules for associated bankruptcy problems. Sufficient conditions on a compromise stable game are derived such that the 1-nucleolus and the nucleolus coincide.

  10. Spot 1 Spot 2

    Indian Academy of Sciences (India)

    2011-08-23

    M)[17]. Gel Idx/Pos. 137/F12. Plate [#] Name. [1] T056P10. Rank. Protein Name. Accession No. Protein. Protein. Total Ion. Total Ion. Score. Score. Score. C. I. %. C. I. %. 1. Serum albumin OS=Mus musculus GN=Alb PE=1 SV= ...

  11. The E1 proteins

    International Nuclear Information System (INIS)

    Bergvall, Monika; Melendy, Thomas; Archambault, Jacques

    2013-01-01

    E1, an ATP-dependent DNA helicase, is the only enzyme encoded by papillomaviruses (PVs). It is essential for replication and amplification of the viral episome in the nucleus of infected cells. To do so, E1 assembles into a double-hexamer at the viral origin, unwinds DNA at the origin and ahead of the replication fork and interacts with cellular DNA replication factors. Biochemical and structural studies have revealed the assembly pathway of E1 at the origin and how the enzyme unwinds DNA using a spiral escalator mechanism. E1 is tightly regulated in vivo, in particular by post-translational modifications that restrict its accumulation in the nucleus. Here we review how different functional domains of E1 orchestrate viral DNA replication, with an emphasis on their interactions with substrate DNA, host DNA replication factors and modifying enzymes. These studies have made E1 one of the best characterized helicases and provided unique insights on how PVs usurp different host-cell machineries to replicate and amplify their genome in a tightly controlled manner. - Highlights: • The papillomavirus E1 helicase orchestrates replication of the viral DNA genome. • E1 assembles into a double-hexamer at the viral origin with the help of E2. • E1 interacts with cellular DNA replication factors. • E1 unwinds DNA using a spiral escalator mechanism. • Nuclear accumulation of E1 is regulated by post-translational modifications

  12. L = ± 1 stellarator

    International Nuclear Information System (INIS)

    Kikuchi, T.; Shiina, S.; Saito, K.; Gesso, H.; Aizawa, M.; Kawakami, I.

    1985-01-01

    We report the magnetic field configuration of helical magnetic axis stellarator. The magnetic field configuration is composed of large l=1 field and small l=-1 and l=0(bumpy) fields. The large l=1 field (combined with the small l=-1 field) is used to form helical magnetic axis with the helical curvature much larger than the toroidal curvature, which provides the high limiting values of β. The small l=-1 field, furthermore, as well as the large l=1 field reduces the Pfirsch-Schlueter currents by combining with l=0 field. Therefore, the large l=1 field and the combination of three field components may be favourable for the increase of limiting β value

  13. Prokineticin1 and pregnancy.

    Science.gov (United States)

    Alfaidy, Nadia

    2016-06-01

    Prokineticin 1 (PROK1), also called EG-VEGF, is a peptide of 86 amino acids with multiple biological functions. PROK1 acts via two G-protein coupled receptors: PROKR1 PROKR2. PROK1 is highly expressed in the placenta. This article reports the expression and the role of PROK1 during normal and pathological pregnancies: (i) during early pregnancy, PROK1 exhibits a peak of placental expression shortly before the establishment of the feto-maternal circulation; (ii) its receptors, PROKR1 PROKR2 are highly expressed in human placenta; (iii) its expression is increased by hypoxia; (iv) PROK1 inhibits extravillous trophoblasts migration and invasion and increases their proliferation and survival; (v) PROK1 is also a pro-angiogenic placental factor that increases microvascular placental endothelial cells proliferation, migration, invasion, and permeability. Circulating PROK1 levels are five times higher in pregnant women during the first trimester compared to the second and third trimesters. Also, its serum levels are higher in patients with preeclampsia (PE) and in patients with isolated intra-uterine growth restriction (IUGR). In mice, maintaining high level of PROK1 beyond its normal period of production (>10.5dpc) reproduces symptoms of PE. To date, our results demonstrated that PROK1 is a central factor of human placentation with direct roles both in the control of trophoblast invasion and villous growth. Thus, a failure in the expression of PROK1 and/or its receptor during pregnancy may contribute to the development of PE and/or IUGR. Besides theses original findings, we also report a direct role of this factor in parturition. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  14. ITER EDA Newsletter. Vol. 1, No. 1

    International Nuclear Information System (INIS)

    1992-11-01

    After the ITER Engineering Design Activities (EDA) Agreement and Protocol 1 had been signed by the four ITER parties on July 21, 1992 and had entered into force, the ITER Council suggested at its first meeting (Vienna, September 10-11, 1992) that the publication of the ITER Newsletter be continued during the EDA with assistance of the International Atomic Energy Agency. This suggestion was supported by the Agency and subsequently the ITER office in Vienna assumed its responsibilities for planning and executing activities related to the publication of the Newsletter. The ITER EDA Newsletter is planned to be a monthly publication aimed at disseminating broad information and understanding, including the description of the personal and institutional involvements in the ITER project in addition to technical facts about it. The responsibility for the Newsletter rests with the ITER council. In this first issue the signing of the ITER EDA Activities and Protocol 1 is reported. The EDA organizational structure is described. This issue also reports on the first ITER EDA council meeting, the opening of the ITER EDA NAKA Co-Centre, the first meeting of the ITER Technical Advisory Committee, activities of special working groups, an ITER Technical Meeting, as well as ''News in Brief'' and ''Coming Events''

  15. 1-Methylpiperazine-1,4-diium dipicrate

    Directory of Open Access Journals (Sweden)

    Grzegorz Dutkiewicz

    2011-02-01

    Full Text Available In the crystal structure of the title compound [systematic name: 1-methylpiperazine-1,4-diium bis(2,4,6-trinitrophenolate], C5H14N22+·2C6H2N3O7−, the ionic components are connected by relatively strong N—H...O hydrogen bonds into centrosymmetric six-membered conglomerates, which comprise two dications and four anions. Besides Coulombic interactions, only weak C—H...O interactions and some stacking between picrates (separation between the planes of ca. 3.4 Å but only a small overlapping can be identified between these `building blocks' of the crystal structure. The piperazine ring adopts a chair conformation with the methyl substituent in the equatorial position. In the picrate anions, the twist angles of the nitro groups depend on their positions relative to the phenolate O atom: it is much smaller for the NO2 groups para to the C—O− group [15.23 (9and 3.92 (14°] than for the groups in the ortho positions [28.76 (13–39.84 (11°].

  16. Thermochemistry of 1,1,3,3-tetramethylguanidine and 1,1,3,3-tetramethylguanidinium nitrate

    International Nuclear Information System (INIS)

    Vitorino, Joana; Agapito, Filipe; Piedade, M. Fátima M.; Bernardes, Carlos E.S.; Diogo, Hermínio P.; Leal, João P.

    2014-01-01

    Graphical abstract: - Highlights: • The enthalpy of formation of 1,1,3,3-tetramethylguanidinium nitrate was determined by combustion calorimetry. • The cohesive energy of liquid 1,1,3,3-tetramethylguanidinium nitrate was evaluated. • The crystal structure of 1,1,3,3-tetramethylguanidinium nitrate was determined by single crystal X-ray diffraction. • Δ f H m o (l/g) of 1,1,3,3-tetramethylguanidine (tmg) were obtained by solution and Calvet calorimetry. • Δ f H m o (g) calculated by the W1-F12 procedure was in excellent agreement with the corresponding experimental value. - Abstract: Considerable efforts have recently been made to investigate how the structure of protic ionic liquids determines some of their most important properties for technological applications (e.g. low vapour pressure, conductivity). In contrast, the assessment of cohesive energies (which are also linked to those properties) based on thermodynamic results is still practically unexplored. This problem is addressed here for 1,1,3,3-tetramethylguanidinium nitrate, [Htmg][NO 3 ], through a combination of experimental and computational chemistry results at the reference temperature of 298.15 K. The standard molar enthalpies of formation, Δ f H m o ([Htmg][NO 3 ],cr)=-(311.8±2.3)kJ·mol -1 , and fusion, Δ fus H m o ([Htmg][NO 3 ])=16.2±3.8kJ·mol -1 , of solid 1,1,3,3-tetramethylguanidinium nitrate (form I polymorph) were obtained by combustion and differential scanning calorimetry, respectively. From these results Δ f H m o ([Htmg][NO 3 ],l)=-(295.6±4.4)kJ·mol -1 could be derived. Also determined were the standard molar enthalpies of formation, Δ f H m o (tmg, l)=7.7±2.8kJ·mol -1 , and vaporisation, Δ vap H m o (tmg,l)=50.0±1.2kJ·mol -1 , of 1,1,3,3-tetramethylguanidine, by reaction solution and Calvet-drop microcalorimetry, respectively, leading to Δ f H m o (tmg,g)=57.7±3.0kJ·mol -1 . This result is in excellent agreement with Δ f H m o (tmg,g)=58.4±4.0kJ·mol -1

  17. Z physics at LEP 1. Vol. 1

    International Nuclear Information System (INIS)

    Altarelli, G.; Kleiss, R.; Verzegnassi, C.

    1989-01-01

    The contents of this final report from the Workshop on Z Physics at LEP can be divided into two parts. The first part, comprising Vols. 1 and 2, is a relatively concise but fairly complete handbook on the physics of e + e - annihilation near the Z peak (with normal LEP luminosity and unpolarized beams, appropriate for the first phase of LEP operation). The second part (Vol. 3) is devoted to a review of the existing Monte Carlo event generators for LEP physics. A special effort has been made to co-ordinate the different parts of this report, with the aim of achieving a systematic and balanced review of the subject, rather than having simply a collection of separate contributions. (orig.)

  18. ALG1-CDG

    DEFF Research Database (Denmark)

    Ng, Bobby G; Shiryaev, Sergey A; Rymen, Daisy

    2016-01-01

    of ALG1-CDG from 32 families and add 26 new mutations. Pathogenicity of each mutation was confirmed based on its inability to rescue impaired growth or hypoglycosylation of a standard biomarker in an alg1-deficient yeast strain. Using this approach we could not establish a rank order comparison......Congenital disorders of glycosylation (CDG) arise from pathogenic mutations in over 100 genes leading to impaired protein or lipid glycosylation. ALG1 encodes a β1,4 mannosyltransferase that catalyzes the addition of the first of nine mannose moieties to form a dolichol-lipid linked oligosaccharide...... intermediate required for proper N-linked glycosylation. ALG1 mutations cause a rare autosomal recessive disorder termed ALG1-CDG. To date 13 mutations in 18 patients from 14 families have been described with varying degrees of clinical severity. We identified and characterized 39 previously unreported cases...

  19. Diabetes mellitus type 1

    OpenAIRE

    Desta, Semere Tekeste

    2017-01-01

    Høgskulen på Vestlandet Avdeling for helsefag for sykepleiere Tittel: Diabetes type 1 Bakgrunn for val av tema: I 2000 var det ca. 130 000 personer i Norge med diabetes, av disse hadde ca. 20 000 diabetes type 1. I dag er det ca. 230 000 personer som har diabetes i Norge. Av disse ca. 28 000 type 1 diabetes. Tallet viser hvor alvorlig sykdommen er, fordi det har vært og fortsatt er, en økning av antall diabetikere i Norge. Type 1 diabetes kan komme i alle aldersgrupper, men vanligvis...

  20. Determination of taste receptor type 1 member 1 (TAS1R1) gene ...

    African Journals Online (AJOL)

    In this article, the objective was to investigate variations in goat TAS1R1 gene and their associations with growth traits in 317 goats by PCR-SSCP and DNA sequencing methods. The results showed two novel single nucleotide polymorphisms (SNPs): HM449123:g. [T3974C, C4037T]. In detail, two different alleles, A and B, ...

  1. 2-[1-(1-Naphthyl-1H-1,2,3-triazol-4-yl]pyridine

    Directory of Open Access Journals (Sweden)

    Ulrich S. Schubert

    2009-05-01

    Full Text Available In the crystal structure of the title compound, C17H12N4, the angle between the naphthalene and 1H-1,2,3-triazole ring systems is 71.02 (4° and that between the pyridine and triazole rings is 8.30 (9°.

  2. HIV-1 envelope glycoprotein

    Science.gov (United States)

    Caulfield, Michael; Cupo, Albert; Dean, Hansi; Hoffenberg, Simon; King, C. Richter; Klasse, P. J.; Marozsan, Andre; Moore, John P.; Sanders, Rogier W.; Ward, Andrew; Wilson, Ian; Julien, Jean-Philippe

    2017-08-22

    The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron microscopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention.

  3. Excavation of LSS1

    CERN Multimedia

    CERN PhotoLab

    1972-01-01

    Excavation of the long straight-section LSS1 by an Alpine boring machine. View of the connection chamber, in the background, the roofs of the enlarged sections (8.5 m and 6 m). On the right, the access tunnel to PP1.

  4. Arginase-1 deficiency.

    Science.gov (United States)

    Sin, Yuan Yan; Baron, Garrett; Schulze, Andreas; Funk, Colin D

    2015-12-01

    Arginase-1 (ARG1) deficiency is a rare autosomal recessive disorder that affects the liver-based urea cycle, leading to impaired ureagenesis. This genetic disorder is caused by 40+ mutations found fairly uniformly spread throughout the ARG1 gene, resulting in partial or complete loss of enzyme function, which catalyzes the hydrolysis of arginine to ornithine and urea. ARG1-deficient patients exhibit hyperargininemia with spastic paraparesis, progressive neurological and intellectual impairment, persistent growth retardation, and infrequent episodes of hyperammonemia, a clinical pattern that differs strikingly from other urea cycle disorders. This review briefly highlights the current understanding of the etiology and pathophysiology of ARG1 deficiency derived from clinical case reports and therapeutic strategies stretching over several decades and reports on several exciting new developments regarding the pathophysiology of the disorder using ARG1 global and inducible knockout mouse models. Gene transfer studies in these mice are revealing potential therapeutic options that can be exploited in the future. However, caution is advised in extrapolating results since the lethal disease phenotype in mice is much more severe than in humans indicating that the mouse models may not precisely recapitulate human disease etiology. Finally, some of the functions and implications of ARG1 in non-urea cycle activities are considered. Lingering questions and future areas to be addressed relating to the clinical manifestations of ARG1 deficiency in liver and brain are also presented. Hopefully, this review will spark invigorated research efforts that lead to treatments with better clinical outcomes.

  5. DNM1 encephalopathy

    DEFF Research Database (Denmark)

    von Spiczak, Sarah; Helbig, Katherine L; Shinde, Deepali N

    2017-01-01

    patients (7 previously published) with DNM1 mutations. We compared mutation data to known functional data and undertook biomolecular modeling to assess the effect of the mutations on protein function. RESULTS: We identified 19 patients with de novo mutations in DNM1 and a sibling pair who had an inherited...

  6. Diabetes Type 1

    Science.gov (United States)

    Diabetes means your blood glucose, or blood sugar, levels are too high. With type 1 diabetes, your pancreas does not make insulin. Insulin is ... kidneys, nerves, and gums and teeth. Type 1 diabetes happens most often in children and young adults ...

  7. PGM1 deficiency

    DEFF Research Database (Denmark)

    Voermans, N C; Preisler, N; Madsen, K L

    2017-01-01

    Mutations in PGM1 (phosphoglucomutase 1) cause Glycogen Storage Disease type XIV, which is also a congenital disorder of protein N-glycosylation. It presents throughout life as myopathy with additional systemic symptoms. We report the effect of oral galactose treatment during five months in a pat...

  8. 1- 4 Falodun

    African Journals Online (AJOL)

    DR. AMIN

    45.3. 2.31 (dd, J = 7.5, 12.8). CH2. 9. 70.7. 5.62 m. CH. 10. 122.9. 5.09 m. CH. 11. 131.2. -. C. 12. 25.5. 1.71 s. CH3. 13. 27.8. 1.30 s. CH3. 14. 16.8. 1.59 s. CH3. 15. 18.2. 1.70 s. CH3. CH3CO. 171.4. -. CH3. CH3CO. 20.2. 1.89 s. CH3. Organisms. Concentrations of seed extracts (mg/ml). 2.5. 5. 10. 20. 25. 50. 100. 200. E.coli.

  9. Type 1 Tyrosinaemia

    LENUS (Irish Health Repository)

    Mannion, MA

    2016-06-01

    Tyrosinaemia type 1 (TYR1, OMIM# 276700) is a rare autosomal recessive disease that results from an enzyme defect that leads to a deficiency in fumarylacetoacetase (FAH)1. We present 3 cases of TYR1 in the Irish population over a 9 year period, the only cases known to have been diagnosed in Ireland since 1989. The common presenting symptom was hypoglycaemia and the diagnosis was made by the identification of the pathognomonic biomarker succinylacetone on urine organic acid analysis. We discuss the clinical presentation, biochemical and genetic results including one novel mutation. We also highlight the importance of early initiation of Nitisinone (NTBC), which reduces the complications of TYR1 and the incidence of liver transplantation in this population2.

  10. Open Praxis, volumen 1 issue 1

    Directory of Open Access Journals (Sweden)

    Editor Open Praxis

    2007-01-01

    Full Text Available Table of Contents - A Study on the Importance of Fostering Trust in a Distance Learning Community Sónia Sousa, David Lamas & Brian Hudson (1-10 - Teacher Upgrading through Distance Education in a South African Context C. G. Kruger & Prof. E. J. Spamer (11-19 - An Investigation into Delivery of On-Line Courses within an Early Childhood Teacher Education Distance Programme in New Zealand Susan E. Smart (20-29 - Transnational Online Project Management Curriculum Model for Engineering Students Enrique Benimeli Bofarull, Anke Muendler, Peter Haber (30-39 - China Rural Distance Education and Construction of the New Countryside Li Fanghong & Zeng Yichun (40-46 - E-Learning in Japan: Steam Locomotive on Shinkansen Ali E. Ozkul, Ph.D. & Kumiko Aoki, Ph.D.  (47-55 - Widening Access to Higher Education: Open and Distance Learning in Higher Education Setting in Indonesia Paulina Pannen (56-65 - Research and Development of a Costing Toolkit for Distance, Flexible and ICT-Based Education for Teacher Development in Africa Frank R J Banks (66-75 - Fostering E-Learning in Medical Education: The Eurovacc Team Experience Guilherme Andrade Marson, Nathalie Debard, Jean-Pierre Kraehenbuhl, Pascal Py, Yan Cornneille, Laurent Richard, Alain Meystre (76-86 - Program Upgrading Teachers in Education Irene Hardy de Gómez (87-95 - ICT based learning strategies for Educating nomads Yogesh Kulkarni & Dr. Madhav Gaikwad (96-102 - Information and Communication Technology and Distance Education in Brazil Marta de Campos Maia & Fernando de Souza Meirelles (103-112 - ICDE’s interview with Susan D’Antoni, UNESCO International Institute for Educational Planning (IIEP (113-117 - ICDE Task Force Open Educational Resources – Inquiry Results (118-125 - 22nd ICDE – World Conference on Distance Education: Facts and figures (126-131

  11. Communication in Mainstream Classrooms: A Matter of Courtesy.

    Science.gov (United States)

    Holcomb, Thomas K.; Foster, Susan

    1992-01-01

    These communication guidelines, for mainstream teachers whose classes include deaf students, stress courtesy. Specific guidelines include (1) maintain visual lines of communication, (2) attend to the speaker (not the interpreter), (3) use pauses to let the interpreter catch up, (4) recognize speakers, and (5) foster a relaxed atmosphere. (DB)

  12. Temporal Analysis of English and Spanish Narratives.

    Science.gov (United States)

    de Johnson, Teresa H.; O'Connell, Daniel C.

    In order to ascertain the effect of different demands on cognitive processes as reflected in speech rate, pause and hesitation phenomena, 90 young men, 45 native speakers of English (U.S.A.) and 45 native speakers of Spanish (Mexico), were asked to retell a story presented in one of three ways: (1) film plus narration; (2) film only; (3) narration…

  13. The Study of the Phenomenon of Hesitation as a Cognitive Process in Iranian French Learners' Oral Production

    Science.gov (United States)

    Rahmatian, Rouhollah; Mehrabi, Marzieh; Safa, Parivash; Golfam, Arsalan

    2014-01-01

    Hesitation, when speaking a foreign language, is studied through its components: beginnings, pauses, and repetitions. This paper aims to identify, through the study of this phenomenon, vulnerable zones among Iranian learners when they speak French. A case study of 30 adult learners shows that hesitation is not random and at different levels (A1 to…

  14. SPOKES: Evaluation Report and Executive Summary

    Science.gov (United States)

    Tracey, Louise; Chambers, Bette; Bywater, Tracey; Elliott, Louise

    2016-01-01

    The SPOKES (Supporting Parents on Kids Education in Schools) programme is a ten-week intervention for parents designed to help struggling readers in Year 1. The programme teaches parents strategies to support their children's reading such as listening to children read, pausing to let them work out words, and praising them when they concentrate and…

  15. A comparative study of the adsorption and hydrogenation of acrolein on Pt(1 1 1), Ni(1 1 1) film and Pt Ni Pt(1 1 1) bimetallic surfaces

    Science.gov (United States)

    Murillo, Luis E.; Chen, Jingguang G.

    In this study we have investigated the reaction pathways for the decomposition and hydrogenation of acrolein (CH 2dbnd CH-CH dbnd O) on Ni/Pt(1 1 1) surfaces under ultra-high vacuum (UHV) conditions using temperature programmed desorption (TPD) and high-resolution electron energy loss spectroscopy (HREELS). While gas-phase hydrogenation products are not observed from clean Pt(1 1 1), the subsurface Pt-Ni-Pt(1 1 1), with Ni residing below the first layer of Pt, is active for the self-hydrogenation of the C dbnd O bond to produce unsaturated alcohol (2-propenol) and the C dbnd C bond to produce saturated aldehyde (propanal), with the latter being the main hydrogenation product without the consecutive hydrogenation to saturated alcohol. For a thick Ni(1 1 1) film prepared on Pt(1 1 1), the self-hydrogenation yields for both products are lower than that from the Pt-Ni-Pt(1 1 1) surface. The presence of pre-adsorbed hydrogen further enhances the selectivity toward C dbnd O bond hydrogenation on the Pt-Ni-Pt(1 1 1) surface. In addition, HREELS studies of the adsorption of the two hydrogenation products, 2-propenol and propanal, are performed on the Pt-Ni-Pt(1 1 1) surface to identify the possible surface intermediates during the reaction of acrolein. The results presented here indicate that the hydrogenation activity and selectivity of acrolein on Pt(1 1 1) can be significantly modified by the formation of the bimetallic surfaces.

  16. Quantum confinement effects in low-dimensional systems

    Indian Academy of Sciences (India)

    2015-06-03

    Jun 3, 2015 ... Quantum confinement effects in low-dimensional systems. Figure 5. (a) Various cuts of the three-dimensional data showing energy vs. momen- tum dispersion relations for Ag film of 17 ML thickness on Ge(111). (b) Photo- emission intensity maps along ¯M– ¯ – ¯K direction. (c) Substrate bands replotted ...

  17. Spacelab Life Sciences-1

    Science.gov (United States)

    Dalton, Bonnie P.; Jahns, Gary; Meylor, John; Hawes, Nikki; Fast, Tom N.; Zarow, Greg

    1995-01-01

    This report provides an historical overview of the Spacelab Life Sciences-1 (SLS-1) mission along with the resultant biomaintenance data and investigators' findings. Only the nonhuman elements, developed by Ames Research Center (ARC) researchers, are addressed herein. The STS-40 flight of SLS-1, in June 1991, was the first spacelab flown after 'return to orbit', it was also the first spacelab mission specifically designated as a Life Sciences Spacelab. The experiments performed provided baseline data for both hardware and rodents used in succeeding missions.

  18. A Distributed Tier-1

    DEFF Research Database (Denmark)

    Fischer, Lars; Grønager, Michael; Kleist, Josva

    2008-01-01

    The Tier-1 facility operated by the Nordic DataGrid Facility (NDGF) differs significantly from other Tier-1s in several aspects: firstly, it is not located at one or a few premises, but instead is distributed throughout the Nordic countries; secondly, it is not under the governance of a single...... organization but instead is a meta-center built of resources under the control of a number of different national organizations. We present some technical implications of these aspects as well as the high-level design of this distributed Tier-1. The focus will be on computing services, storage and monitoring....

  19. Niobium ore OKA-1

    International Nuclear Information System (INIS)

    Steger, H.F.; Bowman, W.S.

    1981-01-01

    A 287-kg sample of a niobium ore, OKA-1, from Oka, Quebec, was prepared as a compositional reference material. OKA-1 was ground to minus 74 μm, blended in one lot, tested for homogeneity by X-ray fluorescence and chemical methods and bottled in 200-g units. In a 'free-choice' round-robin analytical program, 22 laboratories contributed results for niobium in each of two bottles of OKA-1. A statistical analysis of the data gave a recommended value of 0.37 +- 0.01% for niobium

  20. A distributed Tier-1

    Science.gov (United States)

    Fischer, L.; Grønager, M.; Kleist, J.; Smirnova, O.

    2008-07-01

    The Tier-1 facility operated by the Nordic DataGrid Facility (NDGF) differs significantly from other Tier-1s in several aspects: firstly, it is not located at one or a few premises, but instead is distributed throughout the Nordic countries; secondly, it is not under the governance of a single organization but instead is a meta-center built of resources under the control of a number of different national organizations. We present some technical implications of these aspects as well as the high-level design of this distributed Tier-1. The focus will be on computing services, storage and monitoring.

  1. THE E1 PROTEINS

    OpenAIRE

    Bergvall, Monika; Melendy, Thomas; Archambault, Jacques

    2013-01-01

    E1, an ATP-dependent DNA helicase, is the only enzyme encoded by papillomaviruses (PVs). It is essential for replication and amplification of the viral episome in the nucleus of infected cells. To do so, E1 assembles into a double-hexamer at the viral origin, unwinds DNA at the origin and ahead of the replication fork and interacts with cellular DNA replication factors. Biochemical and structural studies have revealed the assembly pathway of E1 at the origin and how the enzyme unwinds DNA usi...

  2. Linac 1, inner structure

    CERN Multimedia

    1968-01-01

    This photo shows the inner structure of Linac 1. As injector to the PS, and later to the Booster, Linac 1 accelerated protons to 50 MeV, but it has also accelerated heavier ions. Fitted with a 520 keV RFQ pre-injector (instead of the original Cockcroft-Walton generator), it delivered protons and heavy ions to LEAR, from 1982 to 1992. After 33 years of faithful service, Linac 1 was dismantled in 1992 to make room for Linac 3 (Pb ions).

  3. 1H-indoles

    Indian Academy of Sciences (India)

    J. Chem. Sci. Vol. 127, No. 3, March 2015, pp. 439–445. c Indian Academy of Sciences. ... impairment; structure activity relationship; cross selectivity; pharmacokinetic profile. 1. ... 5-HT6R belongs to serotonin super family and they are exclu-.

  4. 3+1 Pariisis

    Index Scriptorium Estoniae

    2000-01-01

    Pariisis Arhitektuurigaleriis La Galerie d'Architecture näitus "4 Architectures", kuhu on valitud arhitektuuribürood neljast riigist: 3+1 arhitektid Eestist, Archis Lätist, Private Ideology Leedust, White arkitekter Rootsist.

  5. Volume 9 Number 1

    African Journals Online (AJOL)

    OLUWOLE

    Agro-Science Journal of Tropical Agriculture, Food, Environment and Extension. Volume 9 Number 1 ... of persistent dumping of cheap subsidized food imports from developed ... independence of the inefficiency effects in the two estimation ...

  6. 1 - 5_Bunza

    African Journals Online (AJOL)

    DR. AMINU

    2014-06-01

    Jun 1, 2014 ... ketoacidosis, or hyperosmolar coma (David, 2001). As the disease progresses ... diabetes develop nephropathy, but in type 2 diabetes a considerably smaller ..... in type 2 diabetic patients: A cross-sectional study of frequency,.

  7. Mark 1 Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Mark I Test Facility is a state-of-the-art space environment simulation test chamber for full-scale space systems testing. A $1.5M dollar upgrade in fiscal year...

  8. C2H4ArF2 1,1-Difluoroethane - argon (1/1)

    Science.gov (United States)

    Demaison, J.

    This document is part of Part 1 of Subvolume D 'Asymmetric Top Molecules' of Volume 29 'Molecular Constants Mostly from Microwave, Molecular Beam, and Sub-Doppler Laser Spectroscopy' of Landolt-Börnstein - Group II 'Molecules and Radicals'.

  9. Contaminant Candidate List 1

    Data.gov (United States)

    U.S. Environmental Protection Agency — CCL 1 is a list of contaminants that are currently not subject to any proposed or promulgated national primary drinking water regulations, that are known or...

  10. Class 1 Areas

    Data.gov (United States)

    U.S. Environmental Protection Agency — A "Class 1" area is a geographic area recognized by the EPA as being of the highest environmental quality and requiring maximum protection. Class I areas are areas...

  11. Reference: IDRSZMFER1 [PLACE

    Lifescience Database Archive (English)

    Full Text Available tial involvement of the IDRS cis-element in the developmental and environmental regulation of the AtFer1 ferritin gene from Arabidopsis. Planta. 217: 709-716 (2003) PubMed: 12728319 ...

  12. September 1, 2013

    African Journals Online (AJOL)

    Osondu

    2013-09-01

    Sep 1, 2013 ... the trend and dynamics of soil properties under them. This study ... based on average values of soil properties for the three sampled depths revealed a degradation of organic matter ..... relation to growth and wood quality of.

  13. Probability 1/e

    Science.gov (United States)

    Koo, Reginald; Jones, Martin L.

    2011-01-01

    Quite a number of interesting problems in probability feature an event with probability equal to 1/e. This article discusses three such problems and attempts to explain why this probability occurs with such frequency.

  14. Type 1 diabetes

    DEFF Research Database (Denmark)

    Green, Anders; Kyvik, Kirsten Ohm

    2001-01-01

    Prediction of Type 1 diabetes at individual level is relevant for any possible intervention before clinical disease develops. Currently available markers of Type 1 diabetes include genetic specificities and immune markers, in addition to a positive family history. This chapter reviews the measures...... and methods of importance in predicting Type 1 diabetes. Based on numerical examples it is demonstrated that available markers have a low level of performance, even when combined. Even so, combined marker information may allow for the identification of the large majority of the general population who...... is at very low disease risk. The impact at population level of predicting Type 1 diabetes varies between societies because the performance of markers depends on levels of disease risk and distribution of markers within a population. The incorporation of the influence of non-genetic etiological factors may...

  15. Supplementary 1..2

    Indian Academy of Sciences (India)

    (A) Low-magnification images show eGFP::Orco (Green) localization ... A 1999 Drosophila melanogaster chemosensory and muscle development: Identificaion and ... allele of scalloped of a new locus, SG18.1, in a Gal4 enhancer trap screen.

  16. Technology in L1

    DEFF Research Database (Denmark)

    Elf, Nikolaj Frydensbjerg; Hanghøj, Thorkild; Skaar, Håvard

    2015-01-01

    In recent decades, several Scandinavian research projects have had an explicit focus on how technology intervenes in L1 (or so-called Mother Tongue Education) practices in Swedish, Norwegian and Danish educational contexts, and how this may impact on understanding of the subject. There is currently......-of-school literacy practices. A final finding is the emphasis on teacher uncertainty regarding how and why to integrate technology within existing paradigms of the subject. This calls for further research on how technology may be justified in L1 practice, including various forms of teacher education....... no systematic overview of the documented possibilities and challenges related to the use of technology in L1. At the same time, there is terminological confusion in use of ‘technology’ and related concepts in L1. Finally, there is a general lack of critical reflection on the relation between technological...

  17. Formation of TRAPPIST-1

    Science.gov (United States)

    Ormel, C. W.; Liu, B.; Schoonenberg, D.

    2017-09-01

    We present a model for the formation of the recently-discovered TRAPPIST-1 planetary system. In our scenario planets form in the interior regions, by accretion of mm to cm-size particles (pebbles) that drifted from the outer disk. This scenario has several advantages: it connects to the observation that disks are made up of pebbles, it is efficient, it explains why the TRAPPIST-1 planets are ˜Earth mass, and it provides a rationale for the system's architecture.

  18. Type 1 diabetes

    OpenAIRE

    Atkinson, Mark A; Eisenbarth, George S; Michels, Aaron W

    2013-01-01

    Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge of lifelong insulin administration. Agents that show promise for averting debilitating disease-associated complications have also been identifi...

  19. RFQ1 diagnostic devices

    International Nuclear Information System (INIS)

    Chidley, B.G.; Arbique, G.M.; de Jong, M.S.; McMichael, G.E.; Michel, W.L.; Smith, B.H.

    1991-01-01

    The diagnostic devices in use on RFQ1 will be described. They consist of a double-slit emittance-measuring unit, a 45 degree deflection energy-analysis magnet, parametric current transformers, optical beam sensors, beam-stop current monitors, and an x-ray end-point analyzer. All of these devices are able to operate up to the full output current of RFQ1 (75 mA cw at 0.6 MeV)

  20. 41 CFR 101-1.104-1 - Publication.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Publication. 101-1.104-1 Section 101-1.104-1 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation System § 101-1.104-1...

  1. aflatoxina b1

    Directory of Open Access Journals (Sweden)

    A. Valdivia

    2004-01-01

    Full Text Available Con el objetivo de probar que la suplementación dietética de ácido elágico (AE o N-Acetilcisteína (NAC en pollos de engorda, atenúa los efectos de una intoxicación aguda por la aflatoxina B1 (AFB1, se intoxicaron con AFB1 pura, tres grupos de diez pollos cada uno (3.0 mb/kg pc, IP. Otros tres grupos recibieron solamente el vehículo (aceite de maíz 2.0 ml/kg pc, IP. Cuatro días antes se administró un alimento testigo, o bien, la misma dieta adicionada con AE (2.5 g/kg o NAC (200 mg/kg pc/6 h. A las 24 horas de la administración de AFB1, se cuantificaron las concentraciones hepáticas de glutatión (GSH, de actividad enzimática específica de la transferasa de glutatión (GST, alanina aminotransferasa, aspartato aminotransferasa y de proteínas hepáticas totales. Los resultados mostraron que NAC atenúa el impacto negativo de la AFB1 sobre el crecimiento corporal y al igual que AE, incrementa la GST y revierte parcialmente los efectos de AFB1 sobre GSH, lo cual sugiere que ambas sustancias pudieran conferir un efecto protector de las aves

  2. Gaia DR1 documentation

    Science.gov (United States)

    van Leeuwen, F.; de Bruijne, J. H. J.; Arenou, F.; Comoretto, G.; Eyer, L.; Farras Casas, M.; Hambly, N.; Hobbs, D.; Salgado, J.; Utrilla Molina, E.; Vogt, S.; van Leeuwen, M.; Abreu, A.; Altmann, M.; Andrei, A.; Babusiaux, C.; Bastian, U.; Biermann, M.; Blanco-Cuaresma, S.; Bombrun, A.; Borrachero, R.; Brown, A. G. A.; Busonero, D.; Busso, G.; Butkevich, A.; Cantat-Gaudin, T.; Carrasco, J. M.; Castañeda, J.; Charnas, J.; Cheek, N.; Clementini, G.; Crowley, C.; Cuypers, J.; Davidson, M.; De Angeli, F.; De Ridder, J.; Evans, D.; Fabricius, C.; Findeisen, K.; Fleitas, J. M.; Gracia, G.; Guerra, R.; Guy, L.; Helmi, A.; Hernandez, J.; Holl, B.; Hutton, A.; Klioner, S.; Lammers, U.; Lecoeur-Taïbi, I.; Lindegren, L.; Luri, X.; Marinoni, S.; Marrese, P.; Messineo, R.; Michalik, D.; Mignard, F.; Montegriffo, P.; Mora, A.; Mowlavi, N.; Nienartowicz, K.; Pancino, E.; Panem, C.; Portell, J.; Rimoldini, L.; Riva, A.; Robin, A.; Siddiqui, H.; Smart, R.; Sordo, R.; Soria, S.; Turon, C.; Vallenari, A.; Voss, H.

    2017-12-01

    We present the first Gaia data release, Gaia DR1, consisting of astrometry and photometry for over 1 billion sources brighter than magnitude 20.7 in the white-light photometric band G of Gaia. The Gaia Data Processing and Analysis Consortium (DPAC) processed the raw measurements collected with the Gaia instruments during the first 14 months of the mission, and turned these into an astrometric and photometric catalogue. Gaia DR1 consists of three parts: an astrometric data set which contains the positions, parallaxes, and mean proper motions for about 2 million of the brightest stars in common with the Hipparcos and Tycho-2 catalogues (the primary astrometric data set) and the positions for an additional 1.1 billion sources (the secondary astrometric data set). The primary set forms the realisation of the Tycho-Gaia Astrometric Solution (TGAS). The second part of Gaia DR1 is the photometric data set, which contains the mean G-band magnitudes for all sources. The third part consists of the G-band light curves and the characteristics of 3000 Cepheid and RR Lyrae stars observed at high cadence around the south ecliptic pole. The positions and proper motions in the astrometric data set are given in a reference frame that is aligned with the International Celestial Reference Frame (ICRF) to better than 0.1 mas at epoch J2015.0, and non-rotating with respect to the ICRF to within 0.03 mas yr^-1. For the primary astrometric data set, the typical standard error for the positions and parallaxes is about 0.3 mas, while for the proper motions the typical standard error is about 1 mas yr^-1. Whereas it has been suggested in Gaia Collaboration et al. (2016a) that a systematic component of ∼0.3 mas should be 'added' (in quadrature) to the parallax uncertainties, Brown (2017) clarifies that reported parallax standard errors already include local systematics as a result of the calibration of the TGAS parallax uncertainties by comparison to Hipparcos parallaxes. For the subset of

  3. [Universal electrogustometer EG-1].

    Science.gov (United States)

    Pleskacz, Witold A; Wałkanis, Andrzej; Rapiejko, Piotr; Jurkiewicz, Dariusz

    2009-01-01

    Electrogustometry has been used as a clinical tool for diagnosis and assessment of a variety of conditions. Since the lack of versatile electrogustometer for research and diagnosis, the new electrogustometer EG-1 was developed in 2006. It was done in cooperation between Warsaw University of Technology and Military Institute of Medicine in Warsaw. EG-1 allows quantitative estimation of taste perception threshold using both static and impulse electrogustometry with bipolar electrode. It is a fully autonomous, battery powered and portable instrument. Because of small size and weight, it can be easily placed in any environment. Microprocessor controlled measurement system and user-friendly interface (LCD display with simple keyboard) make EG-1 electrogustometer very handy and flexible in operation. Data obtained during measurements is stored in the internal device memory. After taste examinations measurement data can be transferred to a personal computer via inbuilt USB port for further analysis and storage. EG-1 can generate three predefined variously shaped current impulses: sinus-, saw- and rectangle-shaped. There is an optional possibility of creating own shapes of stimulus puls by the user. The electrical parameters of generated pulses are as follow: current amplitude 1-2000 microA regulated with 1 microA step, stimulus frequency 0(DC)-500 Hz regulated with 5 Hz step, controlable fulfillment factor and signal rise time (optional for automatic measurements). The operator can trigger the stimuli via a hand switch on the bipolar electrode (with gold-plated endings), via keyboard or via additional independent hand switch. Three years of experience collected during EG-1 exploitation allowed to design a new version of electrogustometer EG-2 with a touch panel and color graphical display.

  4. Polymorphisms of UGT1A1*6, UGT1A1*27 & UGT1A1*28 in three major ethnic groups from Malaysia.

    Science.gov (United States)

    Teh, L K; Hashim, H; Zakaria, Z A; Salleh, M Z

    2012-08-01

    Genetic polymorphisms of uridine diphosphate glucuronyltransferase 1A1 (UGT1A1) have been associated with a wide variation of responses among patients prescribed with irinotecan. Lack of this enzyme is known to be associated with a high incidence of severe toxicity. The objective of this study was to investigate the prevalence of three different variants of UGT1A1 (UGT1A1*6, UGT1A1*27 and UGT1A1*28), which are associated with reduced enzyme activity and increased irinotecan toxicity, in the three main ethnic groups in Malaysia (Malays, Chinese and Indians). A total of 306 healthy unrelated volunteers were screened for UGT1A1*28, UGT1A1*6 and UGT1A1*27. Blood samples (5 ml) were obtained from each subject and DNA was extracted. PCR based methods were designed and validated for detection of UGT1A1*, UUGT1A1*27 and UUGT1A1*28. Direct DNA sequencing was performed to validate the results of randomly selected samples. Malays and Indian have two-fold higher frequency of homozygous of UGT1A1*28 (7TA/7TA) which was 8 and 8.8 per cent, respectively compared to the Chinese (4.9%). However, the distribution of UGT1A1*6 and UGT1A1*27 showed no significant differences among them. UGT1A1*27 which has not been detected in Caucasian and African American population, was found in the Malaysian Malays (3.33%) and Malaysian Chinese (2.0%). There was interethnic variability in the frequency of UGT1A1*28 in the Malaysian population. Our results suggest that genotyping of UUGT1A1*6, UGT1A1*28 and UGT1A1*27 need to be performed before patients are prescribed with irinotecan due to their high prevalence of allelic variant which could lead to adverse drug reaction.

  5. Vogtle 1 - ODSCC

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, E.; O' Brien, T.; Leblanc, S.G.; Smith, T.; Mullins, R. [Southern Nuclear (United States)

    2011-07-01

    In the spring of 2008, refueling outage 1R14, Vogtle Electric Generating Plant Unit 1, a 4-loop Westinghouse PWR with Model F Steam Generators and thermally treated Alloy 600 tubes, performed tube pulls to confirm Outside Diameter Stress Corrosion Cracking (ODSCC) at the top of the tubesheet (TTS). During the previous outage, 1R13, Vogtle performed a planned full chemical cleaning of all steam generators. The 1R14 inspection showed a reduction in ODSCC from 1R13 which suggests a reduction in ODSCC initiation with respect to new degradation. At the time of the tube pull, Vogtle had been in-service for approximately 18.4 effective full power years, operated with 18 month fuel cycles, and had a hot leg temperature of 325 C (618 F). The inspections performed to detect this degradation were done with +Point at the TTS {+-} 3 inch (76 mm). The inspections and tube pull process were performed by Westinghouse Field Services. Similarly, respective laboratory analyses were performed by Westinghouse Chemistry Diagnostics and Materials Engineering, at the Science and Technology Center, Churchill, PA, U.S. In addition to examining the pulled tubes from Vogtle, archived tube samples were examined to compare grain structure and manufacturing process heat treatment effectiveness. (authors)

  6. SFR 1 Vault Database

    International Nuclear Information System (INIS)

    Savage, David; Stenhouse, Mike

    2002-04-01

    SKB is carrying out a safety assessment of the operational SFR 1 repository under the auspices of the 'SAFE' (Safety Assessment of Final Repository for Radioactive Operational Waste) project. SKI in turn, is carrying out its own review of SFR 1. The work presented here is a compilation of physical and chemical data for the SFR 1 repository which will be used in radionuclide transport and assessment calculations by SKI. This compilation has focused on the repository itself (engineered barriers plus near-field rock). Data have been compiled for the following: Physical properties (porosity, hydraulic conductivity, bulk density, effective diffusivity); Sorption of radionuclides (on concrete, sand, bentonite, sand-bentonite, and rock); Radionuclide solubility. In addition, issues affecting gas generation at SFR I have been reviewed and placed in context with research conducted for the SFL 3-5 repository

  7. ATF-1 torsatron studies

    International Nuclear Information System (INIS)

    Lyon, J.F.; Carreras, B.A.; Charlton, L.A.

    1983-01-01

    The main advances in the ORNL Stellarator Program since the 1982 IAEA Conference have been: (1) engineering design of the ATF-1 torsatron; (2) extension of 3-D MHD equilibrium and stability studies and calculations of helical axis configurations; (3) study of stable equilibria with greater than or equal to 8% and direct access to the second stability regime; (4) 3-D Monte Carlo and analytic transport calculations which show a large reduction in transport at low collisionality for the absolute value of e phi'/T' greater than or equal to 1; (5) calculation of ambipolar electric fields; and (b) calculation of well confined ion drift surfaces in the ergodic field region outside the last closed flux surface

  8. ATG16L1

    DEFF Research Database (Denmark)

    Salem, Mohammad; Ammitzboell, Mette; Nys, Kris

    2015-01-01

    Genetic variations in the autophagic pathway influence genetic predispositions to Crohn disease. Autophagy, the major lysosomal pathway for degrading and recycling cytoplasmic material, constitutes an important homeostatic cellular process. Of interest, single-nucleotide polymorphisms in ATG16L1...... (autophagy-related 16-like 1 [S. cerevisiae]), a key component in the autophagic response to invading pathogens, have been associated with an increased risk of developing Crohn disease. The most common and well-studied genetic variant of ATG16L1 (rs2241880; leading to a T300A conversion) exhibits a strong...... association with risk for developing Crohn disease. The rs2241880 variant plays a crucial role in pathogen clearance, resulting in imbalanced cytokine production, and is linked to other biological processes, such as the endoplasmic reticulum stress/unfolded protein response. In this review, we focus...

  9. Fatigue 󈨛. Volume 1,

    Science.gov (United States)

    1987-06-01

    277 FATIGUE 87 da/dn (m/ ciclo ) 10 - 07 10 - 08 10 - 0 9 R=0.5 S* • -Long Crack 10-10 e Smax = 195 MPa *Smax = 205 MPa 1Smax = 225 MPa 0.5 1 5 10 AK...MPa/m) Figure 1 Crack growth rate vs stress intensity factor range 10 . da/dn (m/ ciclo ) i0 - ° 09 i0-o -Long crack 10 . ° Smax = 10 Pa 10 Smax...120 NPa Smax = 145 NlPa 0.5 I 10 AKN~~)50 Figure 2 Crack growth rate vs stress intensity factor range 278 FATIGUE 87 da/dn (m/ ciclo ) 10- 10- 0 7 % 10

  10. BIOTECHNOLOGY BIOPRODUCTS "HEALING-1"

    Directory of Open Access Journals (Sweden)

    S. I. Artiukhova

    2014-01-01

    Full Text Available Summary. The article presents data on the development of technology and qualitative research, bio-products «Healing-1». One of the promising directions in food biotechnology is the development of new integrated starter-based consortia of microorganisms, which have higher activity compared with cultures prepared using pure cultures. So it was interesting studies on the development of new biotechnology and bio-based microbial consortium of lactic acid bacteria. Based on the analysis of biotechnological properties of native cultures created a new consortium of microorganisms containing lactic acid streptococci and bacilli, allowing the maximum extent possible to implement the physiological, biochemical and technological potential of microorganisms. Scientifically substantiated and experimentally developed a new biotechnology production of bioproducts «Healing-1», obtained on the basis of microbial consortium with broad spectrum antimicrobial activity. Experimentally investigated quality parameters of organic food «Healing-1» using a new microbial consortium as freshly prepared and during storage. Found that antagonistic activity of microflora bio «Healing-1» with respect to pathogenic and conditionally pathogenic bacteria, as well as its resistance to substances in the gastrointestinal tract of man is more pronounced compared to bioproducts obtained using a separate starter, members of the microbial consortium. It should be noted a more pronounced synthesis of exopolysaccharides in bioproduct «Healing-1», which leads to increased viscosity of the system and improves the consistency of bio. New bioproducts have good organoleptic characteristics and contain a high number of viable cells of lactic acid bacteria. High stability and survival of lactic acid bacteria during storage. In the study of attacked proteins bioproducts digestive proteinases «in vitro» found that the fermentation of milk microbial consortium increases the digestibility

  11. 26 CFR 1.985-1 - Functional currency.

    Science.gov (United States)

    2010-04-01

    ... the currency used in keeping its books and records (as defined in § 1.989(a)-1(d)). The dollar shall... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Functional currency. 1.985-1 Section 1.985-1...) INCOME TAXES Export Trade Corporations § 1.985-1 Functional currency. (a) Applicability and effective...

  12. Opgavesamling Biokemi 1

    DEFF Research Database (Denmark)

    Bjergegaard, Charlotte

    Opgavesamling til bachelorkurset LKEB10077 Biokemi 1. Opgaverne er et supplement til forelæsninger og øvelser og har til formål at støtte op om indlæringen af biokemien. Der er inkluderet ret grundige løsninger til de enkelte opgaver.......Opgavesamling til bachelorkurset LKEB10077 Biokemi 1. Opgaverne er et supplement til forelæsninger og øvelser og har til formål at støtte op om indlæringen af biokemien. Der er inkluderet ret grundige løsninger til de enkelte opgaver....

  13. Diabetes mellitus type 1

    OpenAIRE

    Tøraasen, Lisa Vangen; Al-Sultan, Zainab

    2014-01-01

    Bacheloroppgave i sykepleie, 2014 Hvert år blir rundt 600 nordmenn diagnostisert med sykdommen diabetes type 1, og Norge er et av landene i verden med størst andel av barnediabetes. I dag er det 15 000- 20 000 personer i Norge som har diabetes type 1, og antall barn som får diabetes har fordoblet seg de siste 30 årene (Diabetesforbundet, 2014). Problemstillingen vår gikk ut på hvordan sykepleiere kan veilede og undervise ungdom med nyoppdaget diabetes type på sykehus. Ut i fra litteraturst...

  14. Diabetes mellitus type 1

    OpenAIRE

    Tøraasen, Lisa Vangen; Al-Sultan, Zainab

    2014-01-01

    Hvert år blir rundt 600 nordmenn diagnostisert med sykdommen diabetes type 1, og Norge er et av landene i verden med størst andel av barnediabetes. I dag er det 15 000- 20 000 personer i Norge som har diabetes type 1, og antall barn som får diabetes har fordoblet seg de siste 30 årene (Diabetesforbundet, 2014). Problemstillingen vår gikk ut på hvordan sykepleiere kan veilede og undervise ungdom med nyoppdaget diabetes type på sykehus. Ut i fra litteraturstudiet har vi arbeidet oss frem for å ...

  15. Fessenheim 1, 1989

    International Nuclear Information System (INIS)

    Tarby, S.; Naudet, R.; Montane, C.; Gras, P.

    1990-01-01

    10 years after the preservice inspection in 1979, French legislation required the Fessenheim 1 900 MW reactor unit to undergo specific inspections necessitating a long-duration shut-down. EDF, the French Electricity Board, decided to take advantage of the shut-down to make major improvements to safety, fire detection and fire-fighting systems. Fessenheim 1 was shut down on April 7th 1989 and reconnected to the grid on October 14th in the same year. The overall operation was brought to a successful conclusion. This paper reviews the objectives and preparatives for the operation, describes the key phases and summarizes the main benefits

  16. 3-Ethylindan-1-one

    Directory of Open Access Journals (Sweden)

    Marcel Sonneck

    2017-11-01

    Full Text Available The title compound, C11H12O, has been prepared as a side product in the attempted room-temperature synthesis of (E-1-phenylpent-2-en-1-one. The molecular structure consists of an approximately planar indanone core (r.m.s. deviation = 0.042 Å with the ethyl group protruding from this plane. In the crystal, centrosymmetrically related molecules are linked into dimers by pairs of C—H...O hydrogen bonds, forming rings of R22(10 graph-set motif. The dimers are further connected by C—H...π interactions into chains running parallel to [-101].

  17. Dark U (1)

    International Nuclear Information System (INIS)

    Chang, Chia-Feng; Ma, Ernest; Yuan, Tzu-Chiang

    2015-01-01

    In this talk we will explore the possibility of adding a local U(1) dark sector to the standard model with the Higgs boson as a portal connecting the visible standard model sector and the dark one. We will discuss existing experimental constraint on the model parameters from the invisible width of Higgs decay. Implications of such a dark U(1) sector on phenomenology at the Large Hardon Collider will be addressed. In particular, detailed results for the non-standard signals of multi-lepton-jets that arise from this simple dark sector will be presented. (paper)

  18. Microelectronic systems 1 checkbook

    CERN Document Server

    Vears, R E

    2013-01-01

    Microelectronic Systems 1 Checkbook provides coverage of the Business and Technician Education Council level 1 unit in Microelectronic Systems. However, it can be regarded as a basic textbook in microelectronic systems for a much wider range of studies. Each topic considered in the text is presented in a way that assumes the reader has little prior knowledge of electronics. The aim of the book is to provide an introduction to the concept of systems, to differentiate analogue and digital systems, and to describe the nature of microprocessor-controlled systems. An introduction to programming is

  19. Alpha1-antitrypsin deficiency

    DEFF Research Database (Denmark)

    Stolk, Jan; Seersholm, Niels; Kalsheker, Noor

    2006-01-01

    The Alpha One International Registry (AIR), a multinational research program focused on alpha1-antitrypsin (AAT) deficiency, was formed in response to a World Health Organization recommendation. Each of the nearly 20 participating countries maintains a national registry of patients with AAT defic...

  20. HIV-1 vaccines

    Science.gov (United States)

    Excler, Jean-Louis; Robb, Merlin L; Kim, Jerome H

    2014-01-01

    The development of a safe and effective preventive HIV-1 vaccine remains a public health priority. Despite scientific difficulties and disappointing results, HIV-1 vaccine clinical development has, for the first time, established proof-of-concept efficacy against HIV-1 acquisition and identified vaccine-associated immune correlates of risk. The correlate of risk analysis showed that IgG antibodies against the gp120 V2 loop correlated with decreased risk of HIV infection, while Env-specific IgA directly correlated with increased risk. The development of vaccine strategies such as improved envelope proteins formulated with potent adjuvants and DNA and vectors expressing mosaics, or conserved sequences, capable of eliciting greater breadth and depth of potentially relevant immune responses including neutralizing and non-neutralizing antibodies, CD4+ and CD8+ cell-mediated immune responses, mucosal immune responses, and immunological memory, is now proceeding quickly. Additional human efficacy trials combined with other prevention modalities along with sustained funding and international collaboration remain key to bring an HIV-1 vaccine to licensure. PMID:24637946

  1. Sampler bias -- Phase 1

    International Nuclear Information System (INIS)

    Blanchard, R.J.

    1995-01-01

    This documents Phase 1 determinations on sampler induced bias for four sampler types used in tank characterization. Each sampler, grab sampler or bottle-on-a-string, auger sampler, sludge sampler and universal sampler, is briefly discussed and their physical limits noted. Phase 2 of this document will define additional testing and analysis to further define Sampler Bias

  2. DISCERNMENT IN 1 THESSALONIANS

    African Journals Online (AJOL)

    This article analyses Paul's use of δοκιμάζειν in 1 Thessalonians 5:21 within the context of .... Pauline thinking” and functions as a “translation of the Christ-event into ... 6 Job 12:11; 23:10, with the meaning of “to separate, distinguish, discern,.

  3. Gentilly 1: decontamination program

    International Nuclear Information System (INIS)

    Le, H.; Denault, P.

    1985-01-01

    The Gentilly 1 station, a 250-MW(e) light-water-cooled and heavy-water-moderated nuclear reactor, is being decommissioned to a static state (variant of stage 1) condition by Atomic Energy of Canada Limited (AECL). The scope of the decontamination program at the Gentilly 1 site includes the fuel pool and associated systems, the decontamination center, the laundry, the feedwater pumps and piping systems, the service building ventilation and drainage systems, and miscellaneous floor and wall areas. After an extensive literature review for acceptable decontamination methods, it was decided that the decontamination equipment used at Gentilly 1 during the program would include a hydrolaser, a scarifier, chipping hammers, a steam cleaner, an ultrasonic bath, and cutting tools. In addition, various foams, acids, detergents, surfactants, and abrasives are used alone and in tandem with the above equipment. This paper highlights the result of these decontaminations, their effectiveness, and the recommendation for future application. The methodology in performing these operations are also presented

  4. Synthesis de 1-dotriacotanol

    International Nuclear Information System (INIS)

    Hernandez, L.; Gonzalez, J.C.

    1996-01-01

    In order to prepare isotopic labeled long chain aliphatic primary alcohol's, the synthesis overall yielding and chemical purity of 1-dotriacotanol were 41% and 98%, respectively. This procedure is very useful for carbon-14 and tritium labeling at Beta position of saturated fatty alcohol's

  5. IDEA papers no. 1

    International Nuclear Information System (INIS)

    Garrigues, P.

    2002-04-01

    The Information network on the Economic Development in Aquitaine (IDEA) aims to collect and spread the environmental information concerning the Aquitaine, in order to implement an observatory of the regional environment and of the sustainable development. The IDEA paper no. 1 provides information such as, meeting, Internet addresses and programs, for the month of April 2002. (A.L.B.)

  6. The First Digit 1

    Indian Academy of Sciences (India)

    IAS Admin

    RESONANCE | December 2013. GENERAL | ARTICLE. The First Digit 1. Tanya Kaushal Srivastava. Keywords. Random numbers, unpredict- able, equidistribution, Weyl cri- terion, absorptive property. Tanya Kaushal Srivastava is a BS-MS student at the. Department of Mathemat- ics, IISER Mohali and is a. KVPY fellow.

  7. JOS JOURNAL 1

    African Journals Online (AJOL)

    1 syndrome of congenital anomalies. These syndromes include Holt-Oram syndrome, Down's syndrome, Fanconi Polycytemia, Meckel syndrome, Lawrence Moon Biedl syndrome,. Patau's syndrome and klippel-Trenaunay syndrome. There may also be associated cleft palate, hearing difficulties, renal anomalies, other. 3.

  8. NUMBER 1.pmd

    African Journals Online (AJOL)

    daddy

    TGFâR1 or TGFâR2.2 This abnormality of the protein leads to variable clinical problems particularly affecting the skeletal, ocular, and cardiovascular systems. Nearly 50 percent of patients have to undergo aortic surgery in their lifetime resulting in reconstruction or replacement of the aortic root or total of this vessel's parts.3.

  9. supplementary1.doc

    Indian Academy of Sciences (India)

    Electrochemical preparation of Nitrogen doped Graphene Quantum Dots and their Size-dependent Electrocatalytic Activity for Oxygen Reduction. Dhanraj B. Shindea, Vishal M. Dhavalea, Sreekumar Kurungota* and Vijayamohanan K. Pillaib*. Cyclic voltammetry of different size N-GQDs: Figure S1. Cyclic voltammetry study ...

  10. Krigsfanger under 1. Verdenskrig

    DEFF Research Database (Denmark)

    Krabbe Meyer, Mette Kia

    2016-01-01

    Hvem er de små uniformerede mænd, der stavrer ud af skovbrynet? Nogle med krykker, andre med sygeplejersker eller nydeligt klædte kvinder under armen? Det er krigsfanger, der under 1. Verdenskrig, blev sendt til Danmark for at blive restitueret. Krigsfangelejrene skulle understøtte Danmarks status...

  11. county_1m

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — This is a raster grid dataset (1-Meter Resolution) of the ground points derived from the acquired LiDAR. The Light Detection and Ranging (LiDAR) DEM dataset is a...

  12. JCSC Supporting Information(1).

    Indian Academy of Sciences (India)

    #18, Phase-III, Jeedimetla, ... TLC or HPLC routinely checked for the purity of all compounds. ... 1H-NMR (400 MHz) and 13C-NMR (100 MHz) spectra were recorded in CDCl3 or DMSO using Bruker instrument and Mass spectra were ...

  13. Paper 1: Wastewater characterisation

    African Journals Online (AJOL)

    drinie

    1998). Research is directed on quantifying the C, N and P fractions in the secondary ... and prefermented wastewater, applicable for a basic in-line APT and other prefermenter ... representative composite samples, and from these samples the ... Constituents in true solution (dissolved) (particle size < 1 nm);. • not visible by ...

  14. U(1) problem

    Energy Technology Data Exchange (ETDEWEB)

    McDougall, N.A. (Oxford Univ. (UK). Dept. of Theoretical Physics)

    1984-08-23

    The resolution of the U(1) problem requires the quark condensates to have a specific THETA dependence. We show that the required THETA dependence arises naturally upon application of the index theorem during the calculation of the dynamically generated quark mass.

  15. 1, 2, 3 ... FAIR !

    International Nuclear Information System (INIS)

    Sturm, C.; Sharkov, B.; Stoecker, H.

    2010-01-01

    The Facility for Antiproton and Ion Research FAIR at Darmstadt/Germany will provide worldwide unique accelerator and experimental facilities allowing for a large variety of unprecedented forefront research in hadron, nuclear, atomic and plasma physics and applied sciences. The start version of FAIR, the so called Modularized Start Version includes a basic accelerator as well as three experimental modules - 1, 2, 3 FAIR!

  16. JOS JOURNAL 1

    African Journals Online (AJOL)

    Manga, S.B , Ameh I.G. , Bashir, S. , Muazu, A.G . Danjuma, B , Ibrahim, M. L .,. 4. 5. Abdullahi, K . and Mawak, J . 1. Department of Microbiology, Usmanu Danfodiyo ..... controlled, possibly by aggressive health education and enforcement of compulsory typhoid sensitivity testing for appropriate choice of drugs and effective.

  17. supp1.doc

    Indian Academy of Sciences (India)

    Supporting Information. Salts and cocrystals of Theobromine and their phase transformations in water. PALASH SANPHUI and ASHWINI NANGIA*. School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, Gachibowli, Central University P.O., Hyderabad 500 046, India. Table S1. Hydrogen bonds in crystal ...

  18. Status of PNPP-1

    International Nuclear Information System (INIS)

    Correa, F.S.

    1989-01-01

    The mothballing of the first Philippine Nuclear Power Plant (PNPP-1) in Bagac, Bataan started 1 May 1986 following the change of leadership in the Philippine government. The plant was 98% complete and preoperation was completed in 1985 while awaiting license to load the core. The short term plant lay-up program was implemented first with the objectives of placing the plant in ''CORE LOAD READINESS'' in which 17 systems were placed under the WET lay-up mode of preservation, 59 major components under the DRY lay-up mode, and 46 systems were in operation to support the short term preservation programs. As of the end of Dec 1988 there are 110 systems mothballed, 39 systems still in operation to support the preservation requirements (mostly air-conditioning/ventilating systems, rain water system and electrical/lighting system) and four (4) systems undergoing mothball entry after it was determined not needed to support preservation activities. 94 of the 110 systems are permanent plant systems, the rest auxiliary/ancilliary systems. The nuclear fuels (1 initial core and 1 reload) are still in the plant. (ELC)

  19. 1 - 5_Bunza

    African Journals Online (AJOL)

    DR. AMINU

    2014-06-01

    Jun 1, 2014 ... Diabetic nephropathy is a common phenomenon in patients with diabetes. Its prevalence risk ... ketoacidosis, or hyperosmolar coma (David, 2001). As ..... Haffner, S.M, Stern, M.p, Gruber, M.k, Hazuda, H.P,. Mitchel, M.D,and ...

  20. Type 1 narcolepsy

    DEFF Research Database (Denmark)

    Degn, Matilda; Kornum, Birgitte Rahbek

    2015-01-01

    Type 1 narcolepsy is a sleep disorder characterized by excessive daytime sleepiness with unintentional sleep attacks and cataplexy. The disorder is caused by a loss of hypocretinergic neurons in the brain. The specific loss of these neurons in narcolepsy is thought to result from an autoimmune...

  1. 1 ONLINE RESOURCES

    Indian Academy of Sciences (India)

    Navya

    Trends Ecol. Evol. 13,. 241. http://dx.doi.org/10.1016/S0169-5347(98)01390-1. Mellado-Ortega E. and Hornero-Méndez D. 2012 Isolation and identification of lutein esters, including their regioisomers, in tritordeum (x Tritordeum Ascherson et Graebner) grains: evidence for a preferential xanthophyll acyltransferase activity.

  2. 1,3-Dinitrosoimidazolidine

    Directory of Open Access Journals (Sweden)

    Augusto Rivera

    2012-08-01

    Full Text Available The title compound, C3H6N4O2, exhibits partial disorder with the refined occupancy ratios of the two components being 0.582 (5:0.418 (5. In the major component, the nitroso groups have a relative syn spatial arrangement [O=N...N=O pseudo-torsion angle = 1.1 (4°], whereas the other component has an anti disposition [177.6 (1°]. The N—N=O moieties are almost coplanar with a dihedral angle of 5.3 (3°, while in the minor occupied set of atoms, this angle is 8 (1°. In both components, the imidazolidine ring adopts a twisted conformation on the C—C bond and the crystal structure shows the strain of this ring according to the N—CH2—CH2—N torsion angles [25.9 (5 and −23.8 (7°]. In the crystal, molecules are linked by weak C—H...O hydrogen bonds.

  3. Editorial 9 (1

    Directory of Open Access Journals (Sweden)

    Jana Dlouhá

    2014-05-01

    [1] A further issue which will be comprised of regional sustainability case studies (working title "Social learning processes for regional sustainable development", see here is still under preparation. Shorter examples of regional development highlighting the roles of its actors are welcome to be included in non-research sections or into the related database.

  4. On Euclidean connections for su(1,1), suq(1,1) and the algebraic approach to scattering

    International Nuclear Information System (INIS)

    Ionescu, R.A.

    1994-11-01

    We obtain a general Euclidean connection for su(1,1) and suq(1,1) algebras. Our Euclidean connection allows an algebraic derivation for the S matrix. These algebraic S matrices reduce to the known ones in suitable circumstances. Also, we obtain a map between su(1,1) and su q (1,1) representations. (author). 8 refs

  5. Liquid-air partition coefficients of 1,1-difluoroethane (HFC152a), 1,1,1-trifluoroethane (HFC143a), 1,1,1,2-tetrafluoroethane (HFC134a), 1,1,1,2,2-pentafluoroethane (HFC125) and 1,1,1,3,3-pentafluoropropane (HFC245fa).

    Science.gov (United States)

    Ernstgård, Lena; Lind, Birger; Andersen, Melvin E; Johanson, Gunnar

    2010-01-01

    Blood-air and tissue-blood coefficients (lambda) are essential to characterize the uptake and disposition of volatile substances, e.g. by physiologically based pharmacokinetic (PBPK) modelling. Highly volatile chemicals, including many hydrofluorocarbons (HFC) have low solubility in liquid media. These characteristics pose challenges for determining lambda values. A modified head-space vial equilibrium method was used to determine lambda values for five widely used HFCs. The method is based on automated head-space gas chromatography and injection of equal amount of chemical in two head-space vials with identical air phase volumes but different volumes of the liquid phase. The liquids used were water (physiological saline), fresh human blood, and olive oil. The average lambda values (n = 8) were as follows: 1,1-difluoroethane (HFC152a) - 1.08 (blood-air), 1.11 (water-air) and 5.6 (oil-air); 1,1,1-trifluoroethane (HFC143a) - 0.15, 0.15 and 1.90; 1,1,1,2-tetrafluoroethane (HFC134a) - 0.36, 0.35 and 3.5; 1,1,1,2,2-pentafluoroethane (HFC125) - 0.083, 0.074 and 1.71; and 1,1,1,3,3-pentafluoropropane (HFC245fa) - 0.62, 0.58 and 12.1. The lambda values appeared to be concentration-independent in the investigated range (2-200 ppm). In spite of the low lambda values, the method errors were modest, with coefficients of variation of 9, 11 and 10% for water, blood and oil, respectively.

  6. CYP7B1

    DEFF Research Database (Denmark)

    Roos, P; Svenstrup, K; Danielsen, E R

    2014-01-01

    UNLABELLED: The SPG5A subtype of Hereditary Spastic Paraplegia (HSP) is a rare autosomal recessive neurodegenerative disorder caused by mutations in the CYP7B1 gene, which encodes a steroid cytochrome P450 7α-hydroxylase. This enzyme provides the primary metabolic route for neurosteroids. Clinica......UNLABELLED: The SPG5A subtype of Hereditary Spastic Paraplegia (HSP) is a rare autosomal recessive neurodegenerative disorder caused by mutations in the CYP7B1 gene, which encodes a steroid cytochrome P450 7α-hydroxylase. This enzyme provides the primary metabolic route for neurosteroids.......945_947 dupGGC p.A316AA). CONCLUSION: SPG5A could be characterized as a predominantly pure HSP. MRS showing elevated mI/Cr ratio in the white matter may be indicative of SPG5A....

  7. Vozy formule 1

    OpenAIRE

    Zbožínek, Adam

    2009-01-01

    Tato práce uvádí základní pravidla a předpoklady pro konstrukci a použití vozů formule 1. Hlavní zaměření je na aerodynamiku, která je nejdůležitější disciplínou v tomto motoristickém sportu, dále je tato práce zaměřena na základní faktory týkající se motoru vozu, kol, nové technologie KERS a provedení volantu. This work shows basic rules and conditions for construction and use of cars formula 1. The main part of this work focus on the aerodynamics which is the most important discipline of...

  8. Heat Roadmap Europe 1

    DEFF Research Database (Denmark)

    Connolly, David; Mathiesen, Brian Vad; Østergaard, Poul Alberg

    2012-01-01

    Heat Roadmap Europe (Pre-study 1) investigates the role of district heating in the EU27 energy system by mapping local conditions across Europe, identifying the potential for district heating expansion, and subsequently simulating the potential resource in an hourly model of the EU27 energy system....... In 2010, approximately 12% of the space heating demand in Europe is met by district heating, but in this study four alternative scenarios are considered for the EU27 energy system: 1. 2010 with 30% district heating 2. 2010 with 50% district heating 3. 2030 with 30% district heating 4. 2050 with 50......% district heating These scenarios are investigated in two steps. Firstly, district heating replaces individual boilers by converting condensing power plants to combined heat and power plants (CHP) to illustrate how district heating improves the overall efficiency of the energy system. In the second step...

  9. Evaluation report no.1

    International Nuclear Information System (INIS)

    1995-06-01

    This document, which is the first evaluation report from the French National Evaluation Commission about research on radioactive waste management, was sent to the French Government on June 30, 1995. The Commission was created in January 1994 and started its investigations on April 1994. The evaluation concerns the three axes of the 91-1381 law from December 30, 1991 (1 - separation-transmutation and minimization of wastes, 2 - underground disposal, 3 - choices for conditioning, storage and disposal). The document has been written after hearing of the principal French research organisms. The report focusses on the necessity for a scientific and technical coordination between all the organisms concerned, for a consistent and open analysis of all research topics. This implies a compatibility between schedules and specifications, and with the 15 years allowed by the law. (J.S.). 15 figs., 14 tabs., 4 annexes., 1 glossary

  10. Photospheric oscillations. Pt. 1

    International Nuclear Information System (INIS)

    Fossat, E.; Ricort, G.

    1975-01-01

    Intensity fluctuations in the wings of the Fraunhofer line Na D 1 5896 have been recorded for about two hundred hours at the focus of the Nice coude refractor, using a sodium optical resonance device. Because of the large beam aperture available, records have been made on circular apertures from 22'' up to 32' diameter (the whole sun). The principal results from the analysis of these date are: As shown by White and Cha, the five-minute oscillation has a gaussian random character with a mean lifetime of about 20 min. Its two-dimensional spatial power spectrum is roughly gaussian for every temporal frequency between 2 and 6 MHz. The width of this gaussian spectrum is near 5 x 10 -5 km -1 (i.e. π = 20,000 km). (orig./BJ) [de

  11. Summary: after LS1

    International Nuclear Information System (INIS)

    Pojer, M.; Schmidt, R.

    2012-01-01

    After LS1 the energy will be about 6.5 TeV. The physics potential of LHC is determined by the integrated luminosity useful for the experiments and not only by the peak luminosity. The integrated luminosity is determined by the peak luminosity, the luminosity decay and the efficiency of operation (availability). In this session two of these parameters are addressed, the peak luminosity and the availability. In this paper peak luminosity is discussed through the performance potential of the injectors and through the global performance reach of LHC after LS1. LHC availability is tackled through the issues of the reliability of the magnet powering and of the beam system and of the occurrence of quenches

  12. AAU-BOT1

    DEFF Research Database (Denmark)

    Svendsen, Mads Sølver; Helbo, Jan; Hansen, Michael Rygaard

    2009-01-01

    This paper describes the development of the humanoid robot AAU-BOT1. The purpose of the robot is to investigate human-like walking and in this connection, test prosthetic limbs. AAU-BOT1 has been designed with modularity in mind making it possible to replace, e.g. the lower leg to test transfemoral...... or transtibial prosthesis or orthosis. Recorded motion data from a male test person, along with approximated inertial and mass properties, were used to determine necessary joint torques in human walking which was used as design parameters for the robot. The robot has 19 degrees of freedom (DoF), 17 actuated...... at Aalborg University and supported by the Department of Health Sciences and Technology (HST). To further reduce the cost, the robot uses off-the-shelf hardware which also reduced the time from idea to practical implementation. The result is a low-cost humanoid robot fully assembled and equipped with sensors...

  13. DISP1 code

    International Nuclear Information System (INIS)

    Vokac, P.

    1999-12-01

    DISP1 code is a simple tool for assessment of the dispersion of the fission product cloud escaping from a nuclear power plant after an accident. The code makes it possible to tentatively check the feasibility of calculations by more complex PSA3 codes and/or codes for real-time dispersion calculations. The number of input parameters is reasonably low and the user interface is simple enough to allow a rapid processing of sensitivity analyses. All input data entered through the user interface are stored in the text format. Implementation of dispersion model corrections taken from the ARCON96 code enables the DISP1 code to be employed for assessment of the radiation hazard within the NPP area, in the control room for instance. (P.A.)

  14. Improving surface smoothness and photoluminescence of CdTe(1 1 1)A on Si(1 1 1) substrates grown by molecular beam epitaxy using Mn atoms

    International Nuclear Information System (INIS)

    Wang, Jyh-Shyang; Tsai, Yu-Hsuan; Chen, Chang-Wei; Dai, Zi-Yuan; Tong, Shih-Chang; Yang, Chu-Shou; Wu, Chih-Hung; Yuan, Chi-Tsu; Shen, Ji-Lin

    2014-01-01

    Highlights: • CdTe(1 1 1)A epilayers were grown on Si(1 1 1) substrates by molecular beam epitaxy. • We report an enhanced growth using Mn atoms. • The significant improvements in surface quality and optical properties were found. - Abstract: This work demonstrates an improvement of the molecular beam epitaxial growth of CdTe(1 1 1)A epilayer on Si(1 1 1) substrates using Mn atoms. The reflection high-energy electron diffraction patterns show that the involvement of some Mn atoms in the growth of CdTe(1 1 1)A is even more effective than the use of a buffer layer with a smooth surface for forming good CdTe(1 1 1)A epilayers. 10 K Photoluminescence spectra show that the incorporation of only 2% Mn significantly reduced the intensity of defect-related emissions and considerably increased the integral intensity of exciton-related emissions by a large factor of about 400

  15. 2009 H1N1 Flu Vaccine Facts

    Science.gov (United States)

    ... of this page please turn Javascript on. Feature: Flu 2009 H1N1 Flu Vaccine Facts Past Issues / Fall 2009 Table of ... the H1N1 flu vaccine. 1 The 2009 H1N1 flu vaccine is safe and well tested. Clinical trials ...

  16. 26 CFR 1.1201-1 - Alternative tax.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Alternative tax. 1.1201-1 Section 1.1201-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Wash Sales of Stock Or Securities § 1.1201-1 Alternative tax. (a) Corporations—(1) In...

  17. 48 CFR 1.105-1 - Publication and code arrangement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Publication and code arrangement. 1.105-1 Section 1.105-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Purpose, Authority, Issuance 1.105-1 Publication and code...

  18. 26 CFR 1.267(b)-1 - Relationships.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Relationships. 1.267(b)-1 Section 1.267(b)-1...) INCOME TAXES Items Not Deductible § 1.267(b)-1 Relationships. (a) In general. (1) The persons referred to... partnership separately. Therefore, if the other person and a partner are within any one of the relationships...

  19. 41 CFR 300-1.1 - What is the FTR?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What is the FTR? 300-1.1 Section 300-1.1 Public Contracts and Property Management Federal Travel Regulation System GENERAL INTRODUCTION 1-THE FEDERAL TRAVEL REGULATION (FTR) § 300-1.1 What is the FTR? The FTR is the regulation...

  20. 26 CFR 1.11-1 - Tax on corporations.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Tax on corporations. 1.11-1 Section 1.11-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Tax on Corporations § 1.11-1 Tax on corporations. (a) Every corporation, foreign or domestic, is liable to the tax...

  1. 26 CFR 1.381(c)(5)-1 - Inventories.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Inventories. 1.381(c)(5)-1 Section 1.381(c)(5)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Insolvency Reorganizations § 1.381(c)(5)-1 Inventories. (a) Carryover requirement—(1...

  2. Muons in UA1

    International Nuclear Information System (INIS)

    Dijk, A.L. van.

    1991-01-01

    In the years 1987-1989 the experiment ('UA1'), which is described in this thesis, has focused on measurements with muons. These particles can be considered as a part of the 'fingerprint' of interesting reactions. In the practice of 'UA1', recognizing this 'fingerprint' represents a puzzle because many (often more than hundred particles are produced in a collision between a proton and an anti-proton. In the experiment the properties (charge, energy, direction) of these particles are measured and subsequently the events are reconstructed. This results in several event samples corresponding to specific production mechanisms. The first part (ch. 1-5) of this thesis deals with the muon trigger of the UA1 experiment. This is a computer system that, directly after a measurement, reconstructs an event and checks for the presence of muons. If no muon is found the event is not considered anymore. In the other cases, the event is kept and written to magnetic tape. These tapes are for further analysis. The necessity of a trigger follows from the fact that per second more than 250.000 interactions occur and only about 10 can be saved on tape. For this reason a trigger system is of critical importance: all events not written to tape are lost. In ch. 2 the experiment and in ch. 4 the ideas and constraints of the trigger are explained. Ch. 4 discusses the construction and functioning of the muon trigger and ch. 5 presents the performance. The second part of this thesis (ch.'s 6 and 7) contain the physics analysis results from data collected with muon trigger. These results are explicitly obtained from events containing two muons. The theory is briefly reviewed and a discussion is given of the data and the way the selections are done. Finally the J/Ψ and Γ samples and the cross sections of b-quark production are given. (author). 57 refs.; 60 figs.; 8 tabs

  3. Spacetime extensions Pt. 1

    International Nuclear Information System (INIS)

    Racz, I.

    1991-09-01

    The problem of the existence of local extensions of spacetime is considered. It is shown that for a spacetime including an incomplete inextendible non-coiling causal geodesic curve there exists a particular C k (resp. C k- ) local extension provided that the curvature and its covariant derivatives are well behaved up to order k + 1 (resp. k) along a family of causal geodetics (around the chosen one). (R.P.) 15 refs

  4. RESTAURANT No. 1

    CERN Multimedia

    2002-01-01

    Customers are kindly requested to note the modified opening times of restaurant no. 1 from Monday, February 4 to Sunday, March 3, 2002 : from Monday to Friday 07h00 - 23h00 Saturday / Sunday 08h00 - 21h00 Hot meals will be served between 11h30 and 14h00, then from 18h00 to 19h30. Restaurant Supervisory Committee, tel. 77551

  5. UOA1: Hardware Manual

    Energy Technology Data Exchange (ETDEWEB)

    Wolfers, G.; Sanchez, E.

    2012-07-01

    The UOA1 is a versatile printed circuit board which can be configured to accommodate up to four analogue signal channels of either electrical to optical or optical to electrical converters. A charge-balance voltage to frequency technique is used for the conversion. The board can be adapted to different electrical input or output range and the full scale frequency can be adjusted to provide the best accuracy-to bandwidth compromise for each application. (Author)

  6. Indico 1.0

    International Nuclear Information System (INIS)

    Lopez, J B Gonzalez; Avilés, A; Baron, T; Ferreira, P; Kolobara, B; Pugh, M A; Resco, A; Trzaskoma, J P

    2014-01-01

    Indico has evolved into the main event organization software, room booking tool and collaboration hub for CERN. The growth in its usage has only accelerated during the past 9 years, and today Indico holds more that 215,000 events and 1,100,000 files. The growth was also substantial in terms of functionalities and improvements. In the last year alone, Indico has matured considerably in 3 key areas: enhanced usability, optimized performance and additional features, especially those related to meeting collaboration. Along the course of 2012, much activity has centred around consolidating all this effort and investment into 'version 1.0', recently released in 2013.Version 1.0 brings along new features, such as the Microsoft Exchange calendar synchronization for participants, many new and clean interfaces (badges and poster generation, list of contributions, abstracts, etc) and so forth. But most importantly, it brings a message: Indico is now stable, consolidated and mature after more than 10 years of non-stop development. This message is addressed not only to CERN users but also to the many organisations, in or outside HEP, which have already installed the software, and to others who might soon join this community. In this document, we describe the current state of the art of Indico, and how it was built. This does not mean that the Indico software is complete, far from it! We have plenty of new ideas and projects that we are working on and which we have shared during CHEP 2013.

  7. Point 1 Updates

    CERN Multimedia

    Inigo-Golfin, J.

    The ATLAS experimental area is located in Point 1, just across the main CERN entrance, in the commune of Meyrin. There people are ever so busy to finish the different infrastructures for ATLAS. Not only has Civil Engineering finished the construction of the USA15 technical cavern, but the excavation of the main UX15 cavern has resumed below the machine tunnel, after a brief halt to allow the construction of the UJ-caverns for the power converters of the LHC machine. The excavation work should end in August 2002. The UX15 hand-over to ATLAS is expected in April 2003. On the surface civil engineering is starting to complete the last two surface buildings (SDX1 and SH1), once the services (cooling pipes, ventilation ducts and the largest item, the lift modules and its lift of course) in the shaft PX15 have been completed. But the civil engineering is not all. A lot more is under way. The site installation of the steel structures in the caverns is to begin in Autumn, along with all the cooling pipes, airconditi...

  8. Indico 1.0

    CERN Document Server

    Lopez, J B Gonzalez; Baron, T; Ferreira, P; Kolobara, B; Pugh, M A; Resco, A; Trzaskoma, J P

    2014-01-01

    Indico has evolved into the main event organization software, room booking tool and collaboration hub for CERN. The growth in its usage has only accelerated during the past 9 years, and today Indico holds more that 215,000 events and 1,100,000 files. The growth was also substantial in terms of functionalities and improvements. In the last year alone, Indico has matured considerably in 3 key areas: enhanced usability, optimized performance and additional features, especially those related to meeting collaboration. Along the course of 2012, much activity has centred around consolidating all this effort and investment into 'version 1.0', recently released in 2013.Version 1.0 brings along new features, such as the Microsoft Exchange calendar synchronization for participants, many new and clean interfaces (badges and poster generation, list of contributions, abstracts, etc) and so forth. But most importantly, it brings a message: Indico is now stable, consolidated and mature after more than 10 years of non-stop de...

  9. Vitiligo - Part 1*

    Science.gov (United States)

    Tarlé, Roberto Gomes; do Nascimento, Liliane Machado; Mira, Marcelo Távora; de Castro, Caio Cesar Silva

    2014-01-01

    Vitiligo is a chronic stigmatizing disease, already known for millennia, which mainly affects melanocytes from epidermis basal layer, leading to the development of hypochromic and achromic patches. Its estimated prevalence is 0.5% worldwide. The involvement of genetic factors controlling susceptibility to vitiligo has been studied over the last decades, and results of previous studies present vitiligo as a complex, multifactorial and polygenic disease. In this context, a few genes, including DDR1, XBP1 and NLRP1 have been consistently and functionally associated with the disease. Notwithstanding, environmental factors that precipitate or maintain the disease are yet to be described. The pathogenesis of vitiligo has not been totally clarified until now and many theories have been proposed. Of these, the autoimmune hypothesis is now the most cited and studied among experts. Dysfunction in metabolic pathways, which could lead to production of toxic metabolites causing damage to melanocytes, has also been investigated. Melanocytes adhesion deficit in patients with vitiligo is mainly speculated by the appearance of Köebner phenomenon, recently, new genes and proteins involved in this deficit have been found. PMID:24937821

  10. UA1 prototype detector

    CERN Multimedia

    1980-01-01

    Prototype of UA1 central detector inside a plexi tube. The UA1 experiment ran at CERN's Super Proton Synchrotron and made the Nobel Prize winning discovery of W and Z particles in 1983. The UA1 central detector was crucial to understanding the complex topology of proton-antiproton events. It played a most important role in identifying a handful of Ws and Zs among billions of collisions. The detector was essentially a wire chamber - a 6-chamber cylindrical assembly 5.8 m long and 2.3 m in diameter, the largest imaging drift chamber of its day. It recorded the tracks of charged particles curving in a 0.7 Tesla magnetic field, measuring their momentum, the sign of their electric charge and their rate of energy loss (dE/dx). Atoms in the argon-ethane gas mixture filling the chambers were ionised by the passage of charged particles. The electrons which were released drifted along an electric field shaped by field wires and were collected on sense wires. The geometrical arrangement of the 17000 field wires and 6...

  11. AMF 1 Site Science

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Mark Alan [Rutgers Univ., New Brunswick, NJ (United States)

    2016-08-18

    This report documents progress on DOE Grant# DE-FG02-08ER64531 funded by the Department of Energy’s Atmospheric Systems Research (ASR) program covering the period between its inception in 2008 and its conclusion in 2014. The Atmospheric Radiation Measurement (ARM) Program’s Mobile Facility #1 (AMF#1) is a collection of state-of-the art atmospheric sensing systems including remote and in situ instrumentation designed to characterize the atmospheric column above and in the immediate vicinity of the deployment location. The grant discussed in this report funded the activities of the AMF#1 Site Scientist Team. Broad responsibilities of this team included examining new deployment sites and recommending instrument deployment configurations; data quality control during the early stages of deployments and for certain instruments through the course of the deployment; scientific outreach in the host country or location (particularly international deployments); scientific research oriented toward basic questions about cloud physics and radiation transfer in the deployment region; and training of Ph.D. students to conduct future research relevant to the Atmospheric Systems Research (ASR) program.

  12. Responding for sucrose and wheel-running reinforcement: effect of pre-running.

    Science.gov (United States)

    Belke, Terry W

    2006-01-10

    Six male albino Wistar rats were placed in running wheels and exposed to a fixed interval 30-s schedule that produced either a drop of 15% sucrose solution or the opportunity to run for 15s as reinforcing consequences for lever pressing. Each reinforcer type was signaled by a different stimulus. To assess the effect of pre-running, animals were allowed to run for 1h prior to a session of responding for sucrose and running. Results showed that, after pre-running, response rates in the later segments of the 30-s schedule decreased in the presence of a wheel-running stimulus and increased in the presence of a sucrose stimulus. Wheel-running rates were not affected. Analysis of mean post-reinforcement pauses (PRP) broken down by transitions between successive reinforcers revealed that pre-running lengthened pausing in the presence of the stimulus signaling wheel running and shortened pauses in the presence of the stimulus signaling sucrose. No effect was observed on local response rates. Changes in pausing in the presence of stimuli signaling the two reinforcers were consistent with a decrease in the reinforcing efficacy of wheel running and an increase in the reinforcing efficacy of sucrose. Pre-running decreased motivation to respond for running, but increased motivation to work for food.

  13. Transformation of 1,1,1-trichloroethane in an anaerobic packed-bed reactor at various concentrations of 1,1,1-trichloroethane, acetate and sulfate

    NARCIS (Netherlands)

    deBest, JH; Jongema, H; Weijling, A; Doddema, HJ; Janssen, DB; Harder, W

    Biotransformation of 1,1,1-trichloroethane (CH3CCl3) was observed in an anaerobic packed-bed reactor under conditions of both sulfate reduction and methanogenesis. Acetate (1 mM) served as an electron donor. CH3CCl3 was completely converted up to the highest investigated concentration of 10 mu M.

  14. Characterisation of polymers, 1

    CERN Document Server

    Crompton, Roy

    2008-01-01

    This essential guide to Polymer Characterisation is a complete compendium of methodologies that have evolved for the determination of the chemical composition of polymers. This 478-page book gives an up-to-date and thorough exposition of the state-of-the-art theories and availability of instrumentation needed to effect chemical and physical analysis of polymers. This is supported by approximately 1200 references. Volume 1 covers the methodology used for the determination of metals, non-metals and organic functional groups in polymers, and for the determination of the ratio in which different m

  15. Nonlocal N=1 supersymmetry

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, Tetsuji [Research and Education Center for Natural Sciences, Keio University,Hiyoshi 4-1-1, Yokohama, Kanagawa 223-8521 (Japan); Department of Physics, Tokyo Institute of Technology,Tokyo 152-8551 (Japan); Mazumdar, Anupam [Consortium for Fundamental Physics, Physics Department, Lancaster University,Lancaster LA1 4YB (United Kingdom); Kapteyn Astronomical Institute, University of Groningen,9700 AV Groningen (Netherlands); Noumi, Toshifumi [Institute for Advanced Study, Hong Kong University of Science and Technology,Clear Water Bay (Hong Kong); Department of Physics, Kobe University,Kobe 657-8501 (Japan); Yamaguchi, Masahide [Department of Physics, Tokyo Institute of Technology,Tokyo 152-8551 (Japan)

    2016-10-05

    We construct N=1 supersymmetric nonlocal theories in four dimension. We discuss higher derivative extensions of chiral and vector superfields, and write down generic forms of Kähler potential and superpotential up to quadratic order. We derive the condition in which an auxiliary field remains non-dynamical, and the dynamical scalars and fermions are free from the ghost degrees of freedom. We also investigate the nonlocal effects on the supersymmetry breaking and find that supertrace (mass) formula is significantly modified even at the tree level.

  16. ISR Intersection 1

    CERN Multimedia

    CERN PhotoLab

    1974-01-01

    The experimental apparatus used at intersection 1 by the CERN-Bologna Collaboration (experiment R105). It consists of two almost identical magnetic spectrometers centered at 90 degrees on opposite sides of the intersection region. In each spectrometer one can see magnetostrictive wire spark chambers, a magnet, more chambers and various hodoscopes of scintillation counters. Gas Cerenkov counters (almost invisible in the picture) are located in the gap of each magnet. On the left hand side, a matrix of 119 lead glass Cerenkov counters is located behind some concrete and iron shielding.

  17. Pig PON1

    DEFF Research Database (Denmark)

    Larsen, Knud Erik; Farajzadeh, Leila; Kristensen, Kaja Kjaer

    2018-01-01

    Atherosclerosis is an inflammatory disease promoted by oxidized low density lipoprotein (LDL). High density lipoprotein (HDL) is an important antioxidant, protecting LDL and itself from oxidation and by detoxifying the hydroperoxides from oxidized LDL. Paraoxonase, encoded by the PON1 gene......, is an enzyme involved in oxidant defense by hydrolyzing oxidized lipids, including oxLDL, and in detoxification of organophosphate pesticides. Aging is the major risk factor for developing atherosclerosis and as paraoxonase is responsible for the antioxidant effect of HDL, aging might be accompanied...

  18. Frameworks in CS1

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Caspersen, Michael Edelgaard

    2002-01-01

    In this paper we argue that introducing object-oriented frameworks as subject already in the CS1 curriculum is important if we are to train the programmers of tomorrow to become just as much software reusers as software producers. We present a simple, graphical, framework that we have successfull...... point for introducing graphical user interface frameworks such as Java Swing and AWT as the students are not overwhelmed by all the details of such frameworks right away but given a conceptual road-map and practical experience that allow them to cope with the complexity....

  19. S1 new

    Indian Academy of Sciences (India)

    DMSO Release. ATRi Release. Only EdU. Only ATRi. *. *. *. n.s. n.s. B. 0. 10. 20. 30. 40. 50. 60. 15 mins 20 mins 30 mins 40 mins 60 mins. % o. f p. R a d. 1. 7 p o s tiv e c e lls. HU + DMSO. HU + ATRi. *. *. *. *. n.s. 0. 0. 20. 30. 40. 50. 60. 70. 80. 2 h Treatment. 24 h Treatment γ. H. 2. A. X. P o s i t i v e. N u c l e i. HU+DMSO ...

  20. IUPHAR Review 1

    DEFF Research Database (Denmark)

    Harmar, Anthony J; Fahrenkrug, Jan; Gozes, Illana

    2012-01-01

    in the control of circadian rhythms, learning and memory, anxiety and responses to stress and brain injury. Recent genetic studies also implicate the VPAC(2) receptor in susceptibility to schizophrenia and the PAC(1) receptor in post-traumatic stress disorder. In the periphery, VIP and PACAP play important roles...... in the control of immunity and inflammation, the control of pancreatic insulin secretion, the release of catecholamines from the adrenal medulla and as co-transmitters in autonomic and sensory neurons. This article, written by members of the NC-IUPHAR subcommittee on receptors for VIP and PACAP, confirms...

  1. Viability Assessment Volume 1

    International Nuclear Information System (INIS)

    1998-01-01

    Since May 1996, under its draft Civilian Radioactive Waste Management Program Plan (DOE 1996), DOE has been carrying out a 5-year program of work to support the decision in 2001 by the Secretary of Energy on whether or not to recommend the site to the President. Part of this program was to address major unresolved technical issues and to complete an assessment of the viability of the Yucca Mountain site by 1998. Affirming the DOE plans, Congress directed DOE in the 1997 Energy and Water Development Appropriations Act to provide a viability assessment of the Yucca Mountain site to Congress and the President. This Viability Assessment (VA) document is the DOE report to Congress and the President. They are expected to use the VA to make an informed decision about program direction and funding. Drawing on 15 years of scientific investigation and design work at Yucca Mountain, the VA summarizes a large technical basis of field investigations, laboratory tests, models, analyses, and engineering, described in cited references. The VA identifies the major uncertainties relevant to the technical defensibility of DOE analyses and designs, the DOE approach to managing these uncertainties, and the status of work toward the site recommendation and LA. The VA also identifies DOE plans for the remaining work, and the estimated costs of completing an LA and constructing and operating a repository. The attention to uncertainties is important because DOE must evaluate how the repository will perform during the next 10,000 years or longer. Uncertainties exist because of variability in the natural (geologic and hydrologic) systems at Yucca Mountain and because of imperfect scientific understanding of the natural processes that might affect the repository system. This is Volume 1 and it covers, Introduction and Site Characteristics, includes a high-level summary of the results of the VA and some additional background information. (The overview is bound separately.) Section 1 of Volume

  2. Post LS1 schedule

    CERN Document Server

    Lamont, M

    2014-01-01

    The scheduling limits for a typical long year taking into account technical stops, machine development, spe- cial physics runs are presented. An attempt is then made to outline a ten year post LS1 schedule taking into account the disparate requirements outlined in the previous talks in this session. The demands on the planned long shutdowns and the impact of these demands on their proposed length will be discussed. The option of using ion running as a pre-shutdown cool-down period will be addressed.

  3. Frameworks in CS1

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Caspersen, Michael Edelgaard

    2002-01-01

    point for introducing graphical user interface frameworks such as Java Swing and AWT as the students are not overwhelmed by all the details of such frameworks right away but given a conceptual road-map and practical experience that allow them to cope with the complexity.......In this paper we argue that introducing object-oriented frameworks as subject already in the CS1 curriculum is important if we are to train the programmers of tomorrow to become just as much software reusers as software producers. We present a simple, graphical, framework that we have successfully...

  4. R806 (part 1)

    CERN Multimedia

    CERN PhotoLab

    1976-01-01

    R806 was designed by the BNL-CERN-Syracuse-Yale Collaboration (Bill Willis spokesman) to study large transverse momentum phenomena, and installed in intersection 8 of the ISR. The main detectors were Lithium foil transition radiation detectors to identify electrons and liquid argon calorimeters to measure the energy of the electrons and photons (among the first such calorimeters to be used in an experiment). In part 1 there were two modules, top and bottom of the horizontal beam pipe; the black vertical pipe contains the cryogenics (LN2 and Lar) and is connected to the two modules with the horizontal piping.

  5. Telemetry Standards, Part 1

    Science.gov (United States)

    2015-07-01

    IMAGE FRAME RATE (R-x\\ IFR -n) PRE-TRIGGER FRAMES (R-x\\PTG-n) TOTAL FRAMES (R-x\\TOTF-n) EXPOSURE TIME (R-x\\EXP-n) SENSOR ROTATION (R-x...0” (Single frame). “1” (Multi-frame). “2” (Continuous). Allowed when: When R\\CDT is “IMGIN” IMAGE FRAME RATE R-x\\ IFR -n R/R Ch 10 Status: RO...the settings that the user wishes to modify. Return Value The impact : A partial IHAL <configuration> element containing only the new settings for

  6. ejesm.v10i1.1

    African Journals Online (AJOL)

    USER

    2017-01-16

    Jan 16, 2017 ... Ethiopian Journal of Environmental Studies & Management 10(1): 1 – 10, 2017. ... 1 million, some identified modern sources had also made little impact ..... bottlenecks and logistics. .... Table 1: Trends in Nigerian Stock Market.

  7. Universal graphs at $\\aleph_{\\omega_1+1}$

    OpenAIRE

    Davis, Jacob

    2016-01-01

    Starting from a supercompact cardinal we build a model in which $2^{\\aleph_{\\omega_1}}=2^{\\aleph_{\\omega_1+1}}=\\aleph_{\\omega_1+3}$ but there is a jointly universal family of size $\\aleph_{\\omega_1+2}$ of graphs on $\\aleph_{\\omega_1+1}$. The same technique will work for any uncountable cardinal in place of $\\omega_1$.

  8. ATLAS Point 1 Construction

    CERN Multimedia

    Inigo-Golfin, J

    After 3 years of work in point 1, a number of surface buildings have already been completed and handed over to CERN (the control, the gas and the cooling and ventilation buildings) and, probably more appealing to the public, 60,000 m3 of earth have already been excavated from underground. At present, the technical cavern USA15 and its access shaft are almost finished, leaving only the main cavern and the liaison galleries to be completed in the coming year and a half. The main cavern has been excavated down to the radiation limit and its walls and vault will presently be concreted (see below the picture of the section of the vault with the impressive shell of 1.2 m thickness). The excavation of the bench (27 vertical metres to go yet!) will proceed from August, when some additional civil engineering work in the LHC tunnel will be undertaken. Needless to say many different services are necessary around the detector, both for its installation and future operation for physics. To that end much of the heavy...

  9. (E-1-Phenylethanone semicarbazone

    Directory of Open Access Journals (Sweden)

    Hoong-Kun Fun

    2009-08-01

    Full Text Available In the title compound, C9H11N3O, the benzene ring is disordered over two positions with refined occupancies of 0.922 (5 and 0.078 (5. The program PLATON [Spek (2009. Acta Cryst. D65, 148–155] recommends the solution in the space group C2/m with a = 7.3050 (3, b = 6.6745 (2, c = 18.3853 (6 Å and β = 96.986 (2°. However, the large number of non-extinct reflections needed to be ignored if C2/m is chosen suggested that the space group is incorrect, even though the R values are lower than that for P21/c. The semicarbazone group is essentially planar, with a maximum deviation of 0.046 (1 Å for one of the N atoms. The mean plane of the semicarbazone group forms dihedral angles of 33.61 (8 and 39.1 (9° with the benzene ring of the major and minor components, respectively. In the crystal structure, molecules are linked by intermolecular N—H...O hydrogen bonds into extended chains along the c axis. The crystal structure is further stabilized by weak intermolucular C—H...π interactions.

  10. The Spartan 1 mission

    Science.gov (United States)

    Cruddace, Raymond G.; Fritz, G. G.; Shrewsberry, D. J.; Brandenstein, D. J.; Creighton, D. C.; Gutschewski, G.; Lucid, S. W.; Nagel, J. M.; Fabian, J. M.; Zimmerman, D.

    1989-01-01

    The first Spartan mission is documented. The Spartan program, an outgrowth of a joint Naval Research Laboratory (NRL)/National Aeronautics and Space Administration (NASA)-Goddard Space Flight Center (GSFC) development effort, was instituted by NASA for launching autonomous, recoverable payloads from the space shuttle. These payloads have a precise pointing system and are intended to support a wide range of space-science observations and experiments. The first Spartan, carrying an NRL X-ray astronomy instrument, was launched by the orbiter Discovery (STS51G) on June 20, 1985 and recovered successfully 45 h later, on June 22. During this period, Spartan 1 conducted a preprogrammed series of observations of two X-ray sources: the Perseus cluster of galaxies and the center of our galaxy. The mission was successful from both on engineering and a scientific viewpoint. Only one problem was encountered, the attitude control system (ACS) shut down earlier than planned because of high attitude control system gas consumption. A preplanned emergency mode then placed Spartan 1 into a stable, safe condition and allowed a safe recovery. The events are described of the mission and presents X-ray maps of the two observed sources, which were produced from the flight data.

  11. ATLAS Data Challenge 1

    CERN Document Server

    Poulard, G

    2003-01-01

    In 2002 the ATLAS experiment started a series of Data Challenges (DC) of which the goals are the validation of the Computing Model, of the complete software suite, of the data model, and to ensure the correctness of the technical choices to be made. A major feature of the first Data Challenge (DC1) was the preparation and the deployment of the software required for the production of large event samples for the High Level Trigger (HLT) and physics communities, and the production of those samples as a world-wide distributed activity. The first phase of DC1 was run during summer 2002, and involved 39 institutes in 18 countries. More than 10 million physics events and 30 million single particle events were fully simulated. Over a period of about 40 calendar days 71000 CPU-days were used producing 30 Tbytes of data in about 35000 partitions. In the second phase the next processing step was performed with the participation of 56 institutes in 21 countries (~ 4000 processors used in parallel). The basic elements of ...

  12. Genetic regulation of IL1RL1 methylation and IL1RL1-a protein levels in asthma.

    Science.gov (United States)

    Dijk, F Nicole; Xu, Chengjian; Melén, Erik; Carsin, Anne-Elie; Kumar, Asish; Nolte, Ilja M; Gruzieva, Olena; Pershagen, Goran; Grotenboer, Neomi S; Savenije, Olga E M; Antó, Josep Maria; Lavi, Iris; Dobaño, Carlota; Bousquet, Jean; van der Vlies, Pieter; van der Valk, Ralf J P; de Jongste, Johan C; Nawijn, Martijn C; Guerra, Stefano; Postma, Dirkje S; Koppelman, Gerard H

    2018-03-01

    Interleukin-1 receptor-like 1 ( IL1RL1 ) is an important asthma gene. (Epi)genetic regulation of IL1RL1 protein expression has not been established. We assessed the association between IL1RL1 single nucleotide polymorphisms (SNPs), IL1RL1 methylation and serum IL1RL1-a protein levels, and aimed to identify causal pathways in asthma.Associations of IL1RL1 SNPs with asthma were determined in the Dutch Asthma Genome-wide Association Study cohort and three European birth cohorts, BAMSE (Children/Barn, Allergy, Milieu, Stockholm, an Epidemiological survey), INMA (Infancia y Medio Ambiente) and PIAMA (Prevention and Incidence of Asthma and Mite Allergy), participating in the Mechanisms of the Development of Allergy study. We performed blood DNA IL1RL1 methylation quantitative trait locus (QTL) analysis (n=496) and (epi)genome-wide protein QTL analysis on serum IL1RL1-a levels (n=1462). We investigated the association of IL1RL1 CpG methylation with asthma (n=632) and IL1RL1-a levels (n=548), with subsequent causal inference testing. Finally, we determined the association of IL1RL1-a levels with asthma and its clinical characteristics (n=1101). IL1RL1 asthma-risk SNPs strongly associated with IL1RL1 methylation (rs1420101; p=3.7×10 -16 ) and serum IL1RL1-a levels (p=2.8×10 -56 ). IL1RL1 methylation was not associated with asthma or IL1RL1-a levels. IL1RL1-a levels negatively correlated with blood eosinophil counts, whereas there was no association between IL1RL1-a levels and asthma.In conclusion, asthma-associated IL1RL1 SNPs strongly regulate IL1RL1 methylation and serum IL1RL1-a levels, yet neither these IL1RL1- methylation CpG sites nor IL1RL1-a levels are associated with asthma. Copyright ©ERS 2018.

  13. Epitaxial growth of lithium fluoride on the (1 1 1) surface of CaF 2

    Science.gov (United States)

    Klumpp, St; Dabringhaus, H.

    1999-08-01

    Growth of lithium fluoride by molecular beam epitaxy on the (1 1 1) surface of calcium fluoride crystals was studied by TEM and LEED for crystal temperatures from 400 to 773 K and impinging lithium fluoride fluxes from 3×10 11 to 3×10 14 cm -2 s -1. Growth starts, usually, at the steps on the (1 1 1) surface of CaF 2. For larger step distances and at later growth stages also growth on the terraces between the steps is found. Preferably, longish, roof-like crystallites are formed, which can be interpreted by growth of LiF(2 0 1¯)[0 1 0] parallel to CaF 2(1 1 1)[ 1¯ 0 1]. To a lesser extent square crystallites, i.e. growth with LiF(0 0 1), and, rarely, three-folded pyramidal crystallites, i.e. growth with LiF(1 1 1) parallel to CaF 2(1 1 1), are observed. While the pyramidal crystallites show strict epitaxial orientation with LiF[ 1¯ 0 1]‖CaF 2[ 1¯ 0 1] and LiF[ 1¯ 0 1]‖CaF 2[11], only about 80% of the square crystallites exhibit an epitaxial alignment, where LiF[1 0 0]‖CaF 2[ 1¯ 0 1] is preferred to LiF[1 1 0]‖CaF 2[ 1¯ 0 1]. The epitaxial relationships are discussed on the basis of theoretically calculated adsorption positions of the lithium fluoride monomer and dimer on the terrace and at the steps of the CaF 2(1 1 1) surface.

  14. 26 CFR 1.102-1 - Gifts and inheritances.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Gifts and inheritances. 1.102-1 Section 1.102-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Items Specifically Excluded from Gross Income § 1.102-1 Gifts and inheritances...

  15. 26 CFR 1.502-1 - Feeder organizations.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Feeder organizations. 1.502-1 Section 1.502-1...) INCOME TAXES (CONTINUED) Exempt Organizations § 1.502-1 Feeder organizations. (a) In the case of an organization operated for the primary purpose of carrying on a trade or business for profit, exemption is not...

  16. 26 CFR 1.1311(a)-1 - Introduction.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Introduction. 1.1311(a)-1 Section 1.1311(a)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Readjustment of Tax Between Years and Special Limitations § 1.1311(a)-1 Introduction. (a...

  17. 26 CFR 1.860F-1 - Qualified liquidations.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Qualified liquidations. 1.860F-1 Section 1.860F-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Real Estate Investment Trusts § 1.860F-1 Qualified liquidations. A plan of...

  18. 26 CFR 1.860-1 - Deficiency dividends.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Deficiency dividends. 1.860-1 Section 1.860-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Real Estate Investment Trusts § 1.860-1 Deficiency dividends. Section 860 allows a qualified...

  19. 26 CFR 1.166-1 - Bad debts.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Bad debts. 1.166-1 Section 1.166-1 Internal... TAXES (CONTINUED) Itemized Deductions for Individuals and Corporations § 1.166-1 Bad debts. (a... shall be allowed in respect of bad debts owed to the taxpayer. For this purpose, bad debts shall...

  20. 26 CFR 1.998-1.1000 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 10 2010-04-01 2010-04-01 false [Reserved] 1.998-1.1000 Section 1.998-1.1000 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Domestic International Sales Corporations §§ 1.998-1.1000 [Reserved] ...

  1. 26 CFR 1.162-1 - Business expenses.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Business expenses. 1.162-1 Section 1.162-1...) INCOME TAXES (CONTINUED) Itemized Deductions for Individuals and Corporations § 1.162-1 Business expenses. (a) In general. Business expenses deductible from gross income include the ordinary and necessary...

  2. 26 CFR 1.61-1 - Gross income.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Gross income. 1.61-1 Section 1.61-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Definition of Gross Income, Adjusted Gross Income, and Taxable Income § 1.61-1 Gross...

  3. 26 CFR 1.501(a)-1 - Exemption from taxation.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Exemption from taxation. 1.501(a)-1 Section 1.501(a)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Exempt Organizations § 1.501(a)-1 Exemption from taxation. (a) In...

  4. 26 CFR 1.382-1T - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false [Reserved] 1.382-1T Section 1.382-1T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Insolvency Reorganizations § 1.382-1T [Reserved] ...

  5. 26 CFR 1.73-1 - Services of child.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Services of child. 1.73-1 Section 1.73-1...) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.73-1 Services of child. (a) Compensation for personal services of a child shall, regardless of the provisions of State law relating to who...

  6. 26 CFR 1.761-1 - Terms defined.

    Science.gov (United States)

    2010-04-01

    ... TAXES Definitions § 1.761-1 Terms defined. (a) Partnership. The term partnership means a partnership as... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Terms defined. 1.761-1 Section 1.761-1 Internal... means a member of a partnership. (c) Partnership agreement. For the purposes of subchapter K, a...

  7. Asymmetric oxidation of 1,3-dithianes to 1,3-dithiane 1-oxides

    OpenAIRE

    Yoshihiko, Watanabe; Yojiro, Ono; Yoshio, Ueno; Takeshi, Toru

    1998-01-01

    Oxidation of 2-(1-hydroxy-1-methylethyl)-1,3-dithiane with the Sharpless reagent has been examined under various reaction conditions. Oxidation of 2-(1-hydroxy-1-methylethyl)-1,3-dithiane with Ti(OPri)4-diethyl L-(+)-tartrate-tert-butyl hydroperoxide (1:2:1.5) in CH2Cl2 in the presence of 4 A molecular sieves gives (1S,2S)-2-(1-hydroxy-1-methylethyl)-1,3-dithiane 1-oxide with high trans selectivity and with moderate enantioselectivity. The enantioselectivity depends upon the substituent at t...

  8. Type 1 autoimmune pancreatitis.

    Science.gov (United States)

    Zen, Yoh; Bogdanos, Dimitrios P; Kawa, Shigeyuki

    2011-12-07

    Before the concept of autoimmune pancreatitis (AIP) was established, this form of pancreatitis had been recognized as lymphoplasmacytic sclerosing pancreatitis or non-alcoholic duct destructive chronic pancreatitis based on unique histological features. With the discovery in 2001 that serum IgG4 concentrations are specifically elevated in AIP patients, this emerging entity has been more widely accepted. Classical cases of AIP are now called type 1 as another distinct subtype (type 2 AIP) has been identified. Type 1 AIP, which accounts for 2% of chronic pancreatitis cases, predominantly affects adult males. Patients usually present with obstructive jaundice due to enlargement of the pancreatic head or thickening of the lower bile duct wall. Pancreatic cancer is the leading differential diagnosis for which serological, imaging, and histological examinations need to be considered. Serologically, an elevated level of IgG4 is the most sensitive and specific finding. Imaging features include irregular narrowing of the pancreatic duct, diffuse or focal enlargement of the pancreas, a peri-pancreatic capsule-like rim, and enhancement at the late phase of contrast-enhanced images. Biopsy or surgical specimens show diffuse lymphoplasmacytic infiltration containing many IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis. A dramatic response to steroid therapy is another characteristic, and serological or radiological effects are normally identified within the first 2 or 3 weeks. Type 1 AIP is estimated as a pancreatic manifestation of systemic IgG4-related disease based on the fact that synchronous or metachronous lesions can develop in multiple organs (e.g. bile duct, salivary/lacrimal glands, retroperitoneum, artery, lung, and kidney) and those lesions are histologically identical irrespective of the organ of origin. Several potential autoantigens have been identified so far. A Th2-dominant immune reaction and the activation of regulatory T-cells are assumed

  9. Type 1 autoimmune pancreatitis

    Directory of Open Access Journals (Sweden)

    Zen Yoh

    2011-12-01

    Full Text Available Abstract Before the concept of autoimmune pancreatitis (AIP was established, this form of pancreatitis had been recognized as lymphoplasmacytic sclerosing pancreatitis or non-alcoholic duct destructive chronic pancreatitis based on unique histological features. With the discovery in 2001 that serum IgG4 concentrations are specifically elevated in AIP patients, this emerging entity has been more widely accepted. Classical cases of AIP are now called type 1 as another distinct subtype (type 2 AIP has been identified. Type 1 AIP, which accounts for 2% of chronic pancreatitis cases, predominantly affects adult males. Patients usually present with obstructive jaundice due to enlargement of the pancreatic head or thickening of the lower bile duct wall. Pancreatic cancer is the leading differential diagnosis for which serological, imaging, and histological examinations need to be considered. Serologically, an elevated level of IgG4 is the most sensitive and specific finding. Imaging features include irregular narrowing of the pancreatic duct, diffuse or focal enlargement of the pancreas, a peri-pancreatic capsule-like rim, and enhancement at the late phase of contrast-enhanced images. Biopsy or surgical specimens show diffuse lymphoplasmacytic infiltration containing many IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis. A dramatic response to steroid therapy is another characteristic, and serological or radiological effects are normally identified within the first 2 or 3 weeks. Type 1 AIP is estimated as a pancreatic manifestation of systemic IgG4-related disease based on the fact that synchronous or metachronous lesions can develop in multiple organs (e.g. bile duct, salivary/lacrimal glands, retroperitoneum, artery, lung, and kidney and those lesions are histologically identical irrespective of the organ of origin. Several potential autoantigens have been identified so far. A Th2-dominant immune reaction and the activation of

  10. Uniaxial Compression of Cellular Materials at a 10-1 s-1 Strain Rate Simultaneously with Synchrotron X-ray Computed Tomographic Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Patterson, Brian M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-03-01

    The topic is presented as a series of slides. Motivation for the work included the following: X-ray tomography is a fantastic technique for characterizing a material’s starting structure as well as for non-destructive, in situ experiments to investigate material response; 3D X-ray tomography is needed to fully characterize the morphology of cellular materials; and synchrotron micro-CT can capture 3D images without pausing experiment. Among the conclusions reached are these: High-rate radiographic and tomographic imaging (0.25 s 3D frame rate) using synchrotron CT can capture full 3D images of hyper-elastic materials at a 10-2 strain rate; dynamic true in situ uniaxial loading can be accurately captured; the three stages of compression can be imaged: bending, buckling, and breaking; implementation of linear modeling is completed; meshes have been imported into LANL modeling codes--testing and validation is underway and direct comparison and validation between in situ data and modeled mechanical response is possible.

  11. Is the Routine Check Nephrostogram Following Percutaneous Antegrade Ureteric Stent Placement Necessary?

    International Nuclear Information System (INIS)

    Soh, Keng Chuan; Tay, Kiang Hiong; Tan, Bien Soo; MM Htoo, Austin; HG Lo, Richard; Lin, Shueh En

    2008-01-01

    Our aim was to review our experience with percutaneous antegrade ureteric stent (PAUS) placement and to determine if the routinely conducted check nephrostogram on the day following ureteric stent placement was necessary. Retrospective review of patients who had undergone PAUS placement between January 2004 and December 2005 was performed. There were 83 subjects (36 males, 47 females), with a mean age of 59.9 years (range, 22-94 years). Average follow-up duration was 7.1 months (range, 1-24 months). The most common indications for PAUS placement were ureteric obstruction due to metastatic disease (n = 56) and urinary calculi (n = 34). Technical success was 93.2% (96/103 attempts), with no major immediate procedure-related complications or mortalities. The Bard 7Fr Urosoft DJ Stent was used in more than 95% of the cases. Eighty-one of 89 (91.0%) check nephrostograms demonstrated a patent ureteric stent with resultant safety catheter removal. Three check nephrostograms revealed distal stent migration requiring repositioning by a goose-snare, while five others showed stent occlusion necessitating permanent external drainage by nephrostomy drainage catheter reinsertion. Following PAUS placement, the serum creatinine level improved or stabilized in 82% of patients. The serum creatinine outcome difference between the groups with benign and malignant indications for PAUS placement was not statistically significant (p = 0.145) but resolution of hydronephrosis was significantly better (p = 0.008) in patients with benign indications. Percutaneous antegrade ureteric stent placement is a safe and effective means of relief for ureteric obstruction. The check nephrostogram following ureteric stent placement was unnecessary in the majority of patients

  12. BACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia

    Directory of Open Access Journals (Sweden)

    Zhengrong Zhang

    2017-09-01

    Full Text Available Schizophrenia is a chronic psychiatric disorder with a lifetime prevalence of about 1% in the general population. Recent studies have shown that Neuregulin-1 (Nrg1 is a candidate gene for schizophrenia. At least 15 alternative splicing of NRG1 isoforms all contain an extracellular epidermal growth factor (EGF-like domain, which is sufficient for Nrg1 biological activity including the formation of myelin sheaths and the regulation of synaptic plasticity. It is known that Nrg1 can be cleaved by β-secretase (BACE1 and the resulting N-terminal fragment (Nrg1-ntf binds to receptor tyrosine kinase ErbB4, which activates Nrg1/ErbB4 signaling. While changes in Nrg1 expression levels in schizophrenia still remain controversial, understanding the BACE1-cleaved Nrg1-ntf and Nrg1/ErbB4 signaling in schizophrenia neuropathogenesis is essential and important. In this review paper, we included three major parts: (1 Nrg1 structure and cleavage pattern by BACE1; (2 BACE1-dependent Nrg1 cleavage associated with schizophrenia in human studies; and (3 Animal studies of Nrg1 and BACE1 mutations with behavioral observations. Our review will provide a better understanding of Nrg1 in schizophrenia and a potential strategy for using BACE1 cleavage of Nrg1 as a unique biomarker for diagnosis, as well as a new therapeutic target, of schizophrenia.

  13. LGBTQ Youth Part 1.

    Science.gov (United States)

    Perron, Tracy; Kartoz, Connie; Himelfarb, Chaya

    2017-03-01

    In order to provide holistic care, school nurses must be culturally competent by being sensitive to health disparities experienced by students in at-risk populations. Despite the growing acceptance toward gender and sexual minorities, LGBTQ youth remain an at-risk population in our communities and our schools. School nurses as well as school counselors, social workers, and psychologists can increase their cultural competence in caring for this group of students by increasing their understanding of appropriate terminology and risks associated with this vulnerable group. This article is Part 1 of a two-article series designed to increase school nurses' abilities to advocate and care for LGBTQ youth in school settings. This first article provides information regarding proper terminology and current percentages of youth who identify as LGBTQ and concludes with implications for school nurses, including resources for nurses, school staff, and families.

  14. Curiosities at c=1

    International Nuclear Information System (INIS)

    Ginsparg, P.

    1988-01-01

    We consider conformal field theories on a torus with central charge c=1, and in particular models based upon modding out string propagation on the SU(2) group manifold by its finite subgroups. We find that the partition functions for these models coincide with the continuum limit partition functions of a recently introduced class of RSOS models, defined in terms of the extended Dynkin diagrams of simply-laced Lie algebras, thus giving an alternative interpretation for the primary fields in these latter theories. Three of the models have no massless moduli and thus do not lie on the same line of critical points with the rest. The particular correspondence between simply-laced Lie algebras and finite subgroups of SU(2) that emerges coincides with that which has already appeared in other mathematical contexts. (orig.)

  15. Frameworks in CS1

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Caspersen, Michael Edelgaard

    2002-01-01

    point for introducing graphical user interface frameworks such as Java Swing and AWT as the students are not overwhelmed by all the details of such frameworks right away but given a conceptual road-map and practical experience that allow them to cope with the complexity.......In this paper we argue that introducing object-oriented frameworks as subject already in the CS1 curriculum is important if we are to train the programmers of tomorrow to become just as much software reusers as software producers. We present a simple, graphical, framework that we have successfully...... used to introduce the principles of object-oriented frameworks to students at the introductory programming level. Our framework, while simple, introduces central abstractions such as inversion of control, event-driven programming, and variability points/hot-spots. This has provided a good starting...

  16. The H1 detector

    International Nuclear Information System (INIS)

    Cozzika, G.

    1992-11-01

    The H1 detector presently operating at the HERA e-p collider is described. A general overview of the detector is given with particular emphasis on the calorimeters, the main element of which is a liquid Argon calorimeter enclosed within a large radius solenoid. Calorimetry in the proton direction, close to the beam-pipe is provided by a copper-silicon pad hadronic calorimeter. In the electron direction a lead-scintillator electromagnetic calorimeter closes the solid angle between the rear part of the liquid Argon calorimeter and the beam-pipe. An iron limited streamer tube tail catcher using the return yoke of the solenoid as absorber completes the calorimetry of the detector. The hardware triggers derived from the calorimeters are also described and some performance details of the calorimeters are given

  17. Moessbauer experiments, ch. 1

    International Nuclear Information System (INIS)

    Maring, K.W.

    1977-01-01

    The magnetic properties of iron base alloys have been investigated as a function of the concentrations of the sp-elements Al, Si, Ga, Ge, As, Sn, and Sb. An extensive description of the Moessbauer Effect Spectroscopy (MES) technique is given. The results of MES experiments at room temperature for FeX alloys (X stands for one of the sp-elements) and impurity concentrations of 1, 3 and 5 a/o are presented. Through temperature dependant measurements the hyperfine fields H ((m,n)T) at iron nuclei in different surroundings are obtained. The change of the Curie temperature of the various dilute iron-base alloys, with respect to pure iron, as a function of the impurity concentration is investigated. Average magnetic hyperfine fields and isomer shifts measured at 119 Sn nuclei in Fe 119 Sn are discussed

  18. Petroleum resources assessment 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    This report consists of two articles. (1) Petroleum resources assessment of the Okinawa Trough: The hydrocarbon potential has been evaluated for the Tertiary strata in the northwestern margin of the Okinawa Trough on the basis of the pale-ontological, petrological, geochemical data from two wells (Nikkan 8-9 and JDZ 7-3), and geophysical data. (2) Petroliferous basin analysis in Jinju area (2): Petroleum geological studies such as stratigraphy, sedimentology, petrology and organic geochemistry were carried out in the Gyeongsang Supergroup, Junju area. Based on lithofacies and rock color, the sequence can be divided into seven formations which can be organized into two groups (Sindong Group: Nagdong, Hasandong and Jinju formations in ascending order; Hayang Group: Chilgog, Silla Conglomerate, Haman and Jindong formations). (author). 57 refs.

  19. Criticality handbook. Pt. 1

    International Nuclear Information System (INIS)

    Heinicke, W.; Krug, H.; Thomas, W.; Weber, W.; Gmal, B.

    1985-12-01

    The GRS Criticality Handbook is intended as a source of information on criticality problems for the persons concerned in industry, authorities, or research laboratories. It is to serve as a guide allowing quick and appropriate evaluation of criticality problems during design or erection of nuclear installations. This present issue replaces the one published in 1979, presenting revised and new data in a modified construction, but within the framework of the proven basic structure of the Handbook. Some fundamental knowledge is required of criticality problems and the relevant terms and definitions of nuclear safety, in order to fully deploy the information given. Part 1 of the Handbook therefore first introduces terminology and definitions, followed by experimental methods and calculation models for criticality calculations. The next chapters deal with the function and efficiency of neutron reflectors and neutron absorbers, measuring methods for criticality monitoring, organisational safety measures, and criticality accidents and their subsequent analysis. (orig./HP) [de

  20. Overview of EHN1

    CERN Multimedia

    1982-01-01

    The beams enter from the bottom of the photo. Starting from left (Jura side)three experiments lay upstream of the European Hybrid Spectrometer (EHS), NA20, NA25 (with a small HOlographic Bubble Chamber, HOBC) and NA24. The EHS houses NA21, NA22 and NA23 with the Rapid Cycling Bubble Chamber RCBC, NA26, NA27 with the HOlographic LExan Bubble Chamber, HOLEBC. Along the beam line most at the right (H8) lays the NA3 setup, while downstream one sees the assembly of the GAMS detector (blue) of the CERN/USSR experiment NA12. At the centre run the beam H2/E2 for the FRAMM experiments NA1 (now completed), NA7 and NA29, and the beam H6 for NA30 and NA11.

  1. NCAM1 Polysialylation

    Directory of Open Access Journals (Sweden)

    Mohadeseh Mehrabian

    2016-11-01

    Full Text Available Much confusion surrounds the physiological function of the cellular prion protein (PrPC. It is, however, anticipated that knowledge of its function will shed light on its contribution to neurodegenerative diseases and suggest ways to interfere with the cellular toxicity central to them. Consequently, efforts to elucidate its function have been all but exhaustive. Building on earlier work that uncovered the evolutionary descent of the prion founder gene from an ancestral ZIP zinc transporter, we recently investigated a possible role of PrPC in a morphogenetic program referred to as epithelial-to-mesenchymal transition (EMT. By capitalizing on PrPC knockout cell clones in a mammalian cell model of EMT and using a comparative proteomics discovery strategy, neural cell adhesion molecule-1 emerged as a protein whose upregulation during EMT was perturbed in PrPC knockout cells. Follow-up work led us to observe that PrPC regulates the polysialylation of the neural cell adhesion molecule NCAM1 in cells undergoing morphogenetic reprogramming. In addition to governing cellular migration, polysialylation modulates several other cellular plasticity programs PrPC has been phenotypically linked to. These include neurogenesis in the subventricular zone, controlled mossy fiber sprouting and trimming in the hippocampal formation, hematopoietic stem cell renewal, myelin repair and maintenance, integrity of the circadian rhythm, and glutamatergic signaling. This review revisits this body of literature and attempts to present it in light of this novel contextual framework. When approached in this manner, a coherent model of PrPC acting as a regulator of polysialylation during specific cell and tissue morphogenesis events comes into focus.

  2. 40 CFR 721.10086 - Ethane, 2-(difluoromethoxy)-1,1,1-trifluoro-.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Ethane, 2-(difluoromethoxy)-1,1,1... Specific Chemical Substances § 721.10086 Ethane, 2-(difluoromethoxy)-1,1,1-trifluoro-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as ethane, 2...

  3. Decommissioning of NPP A-1

    International Nuclear Information System (INIS)

    Anon

    2009-01-01

    In this presentation the Operation history of A1 NPP, Project 'Decommissioning of A1 NPP' - I stage, Project 'Decommissioning of A1 NPP ' - II stage and Next stages of Project 'Decommissioning of A1 NPP ' are discussed.

  4. Polarity driven morphology of CeO2(1 0 0) islands on Cu(1 1 1)

    International Nuclear Information System (INIS)

    Stetsovych, O.; Beran, J.; Dvořák, F.; Mašek, K.; Mysliveček, J.; Matolín, V.

    2013-01-01

    Thin ceria films supported by metal substrates represent important model systems for reactivity studies in heterogeneous catalysis. Here we report the growth study of the polar CeO 2 (1 0 0) phase as part of a mixed CeO 2 (1 1 1)–CeO 2 (1 0 0) thin film supported by Cu(1 1 1). The two ceria phases grow on different areas of the substrate, what allows a reliable growth characterization of the CeO 2 (1 0 0) islands on Cu(1 1 1). Scanning tunneling microscopy measurements reveal CeO 2 (1 0 0) to grow in the form of highly dispersed three dimensional (3D) islands on a CeO 2 (1 0 0) interfacial layer. The CeO 2 (1 0 0) islands exhibit a 2 × 2 surface reconstruction. The presence of the surface reconstruction together with the highly dispersed growth of CeO 2 (1 0 0) islands corresponds to the requirement for compensation of the surface dipole moment on the CeO 2 (1 0 0). CeO 2 (1 0 0) islands are further characterized by reflection high energy electron diffraction yielding their epitaxial relations with respect to the Cu(1 1 1) substrate. The growth of well characterized CeO 2 (1 0 0) islands supported by Cu(1 1 1) represents a starting point for developing a novel template for structure-related reactivity studies of ceria based model catalysts.

  5. Closed expressions for $\\int_{0}^{1} t^{-1} log^{n-1}t log^{p}(1 - t) dt$

    CERN Document Server

    Kölbig, Kurt Siegfried

    1982-01-01

    Closed expressions for the integral integral /sub 0//sup 1/ t/sup -1/ log/sup n-1/t log/sup p/(1-t)dt, whose general form is given elsewhere, are listed for n=1(1)9, p=1(1)9. A formula is derived which allows an easy evaluation of these expressions by formula manipulation on a computer. The majority of the above expressions are given in a microfiche supplement to the paper.

  6. 26 CFR 1.1021-1 - Sale of annuities.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Sale of annuities. 1.1021-1 Section 1.1021-1...) INCOME TAXES Basis Rules of General Application § 1.1021-1 Sale of annuities. In the case of a transfer for value of an annuity contract to which section 72(g) and paragraph (a) of § 1.72-10 apply, the...

  7. MELLITUS TIPO 1

    Directory of Open Access Journals (Sweden)

    Luciana Vládia Carvalhêdo Fragoso

    2010-01-01

    Full Text Available Investigación de carácter cualitativo, con el objetivo de comprender las experiencias cotidianas de los adolescentes con diabetes tipo 1. Los sujetos del estudio son 14 adolescentes atendidos en una clínica para la diabetes en Fortaleza, Ceará, Brasil, de junio a octubre de 2008. La recolección de los datos se hizo a través de entrevistas semi-estructuradas y se organizaron de acuerdo al análisis de contenido de Morse y Field. Se observó que el descubrimiento de la diabetes fue un momento difícil para los adolescentes debido a los cambios que tuvieron que hacer como el control terapéutico. Hacer una dieta adecuada es muy difícil como consecuencia de estímulos internos y externos a que están sometidos y a las dificultades financieras. Los adolescentes tienen el apoyo de la familia y amigos para su tratamiento diario. Además, les gusta el servicio realizado por los profesionales de salud de la clínica. Sin embargo, hay mucho que mejorar como enfermeras en la valorización de las experiencias de la vida de los adolescentes con diabetes, como la identificación de factores que interfieren en el control metabólico.

  8. Quenches after LS1

    International Nuclear Information System (INIS)

    Verweij, A.P.

    2012-01-01

    In this paper I will give an overview of the different types of quenches that occur in the LHC, followed by an estimate of the number of quenches that we can expect after LS1. Beam-induced quenches and false triggering of the QPS will be the main cause of those quenches that cause a beam dump. Possibly in total up to 10-20 per year. After consolidation of the 13 kA joints, the approach for the BLM settings can be less conservative than in 2010-2012 in order to maximize beam time. This will cause some quenches but, anyhow, a beam.induced quench is not more risky than a quench provoked by false triggering. It is not easy to predict the number of BLM triggered beam dumps, needed to avoid magnet quenches, because it is not sure how to scale beam losses and UFO's from 3.5 TeV to 6.5 TeV, and it is not sure if the thresholds at 3.5 TeV are correct. Quench events will be much more massive (ex: RB quench at 6 kA → 2 MJ, RB quench at 11 kA → 6-20 MJ), and as a result cryo recuperation much longer. There will also be more ramp induced quenches after a FPA in other circuits due to higher ramp rates and smaller temperature margins (mutual coupling)

  9. B1 Aerogels

    DEFF Research Database (Denmark)

    Duer, Karsten; Svendsen, Sv Aa Højgaard

    1996-01-01

    , engineering and architectural basis which will support the appropriate use of aerogels in windows, solar collectors and passive solar applications, with the aim of saving or producing thermal energy for use in buildings".This objective is in very good agreement with the general scope of task 18 but where Task...... of aerogel as a material for window applications3. Construction of an aerogel DGU and measurement of key performance parameters. The goal for the aerogel DGU was to reach a Total Solar Energy Transmittance above 0.75 and a U-value below 0.5 W/m²K. These are values that can not be simultaneously reached......The report summarizes the work that has been carried out within the project "B1 AEROGELS" as a part of the IEA SH&CP Task 18 "Advanced Glazing and Associated Materials For Solar And Building Applications".By providing at the same time thermal insulation and transparency the silica aerogel is a very...

  10. A comparative study on GM (1,1) and FRMGM (1,1) model in forecasting FBM KLCI

    Science.gov (United States)

    Ying, Sah Pei; Zakaria, Syerrina; Mutalib, Sharifah Sakinah Syed Abd

    2017-11-01

    FTSE Bursa Malaysia Kuala Lumpur Composite Index (FBM KLCI) is a group of indexes combined in a standardized way and is used to measure the Malaysia overall market across the time. Although composite index can give ideas about stock market to investors, it is hard to predict accurately because it is volatile and it is necessary to identify a best model to forecast FBM KLCI. The objective of this study is to determine the most accurate forecasting model between GM (1,1) model and Fourier Residual Modification GM (1,1) (FRMGM (1,1)) model to forecast FBM KLCI. In this study, the actual daily closing data of FBM KLCI was collected from January 1, 2016 to March 15, 2016. GM (1,1) model and FRMGM (1,1) model were used to build the grey model and to test forecasting power of both models. Mean Absolute Percentage Error (MAPE) was used as a measure to determine the best model. Forecasted value by FRMGM (1,1) model do not differ much than the actual value compare to GM (1,1) model for in-sample and out-sample data. Results from MAPE also show that FRMGM (1,1) model is lower than GM (1,1) model for in-sample and out-sample data. These results shown that FRMGM (1,1) model is better than GM (1,1) model to forecast FBM KLCI.

  11. 26 CFR 1.280B-1 - Demolition of structures.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Demolition of structures. 1.280B-1 Section 1... (CONTINUED) INCOME TAXES Items Not Deductible § 1.280B-1 Demolition of structures. (a) In general. Section 280B provides that, in the case of the demolition of any structure, no deduction otherwise allowable...

  12. 26 CFR 1.642(e)-1 - Depreciation and depletion.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Depreciation and depletion. 1.642(e)-1 Section 1... (CONTINUED) INCOME TAXES Estates, Trusts, and Beneficiaries § 1.642(e)-1 Depreciation and depletion. An estate or trust is allowed the deductions for depreciation and depletion, but only to the extent the...

  13. 26 CFR 1.832-1 - Gross income.

    Science.gov (United States)

    2010-04-01

    ..., except that in the case of a mutual fire insurance company described in § 1.831-1 the amount of single... TAXES Other Insurance Companies § 1.832-1 Gross income. (a) Gross income as defined in section 832(b)(1... approved by the National Convention of Insurance Commissioners, as well as the gain derived from the sale...

  14. 26 CFR 1.3-1 - Application of optional tax.

    Science.gov (United States)

    2010-04-01

    ..., appropriate to his number of exemptions, provided for cases in which a joint return is filed. (c) Use of tax... in the case of a joint return (including the return of a surviving spouse) and lesser income... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Application of optional tax. 1.3-1 Section 1.3-1...

  15. 26 CFR 1.678(d)-1 - Renunciation of power.

    Science.gov (United States)

    2010-04-01

    ... (CONTINUED) INCOME TAXES Grantors and Others Treated As Substantial Owners § 1.678(d)-1 Renunciation of power. Section 678(a) does not apply to a power which has been renounced or disclaimed within a reasonable time... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Renunciation of power. 1.678(d)-1 Section 1.678...

  16. 26 CFR 1.615-1 - Pre-1970 exploration expenditures.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Pre-1970 exploration expenditures. 1.615-1 Section 1.615-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME... before January 1, 1970) for ascertaining the existence, location, extent, or quality of any deposit of...

  17. (H1N1) Influenza in Saurashtra, India

    African Journals Online (AJOL)

    Mexico in April, 2009,[1] and then in United States (US).[2,3]. This was originally ... duration of hospital stay of such patients was 2‑32 days. All admitted A (H1N1) .... Because of limited resources, only 2009 A (H1N1) influenza virus was tested ...

  18. 1 CFR 6.1 - Index to daily issues.

    Science.gov (United States)

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Index to daily issues. 6.1 Section 6.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER INDEXES AND ANCILLARIES § 6.1 Index to daily issues. Each daily issue of the Federal Register shall be appropriately indexed. ...

  19. 41 CFR 60-1.1 - Purpose and application.

    Science.gov (United States)

    2010-07-01

    ... obligations under the equal opportunity clause regardless of whether or not his contract contains a “Disputes... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Purpose and application. 60-1.1 Section 60-1.1 Public Contracts and Property Management Other Provisions Relating to Public...

  20. 1 CFR 18.1 - Original and copies required.

    Science.gov (United States)

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Original and copies required. 18.1 Section 18.1... PROCESSING OF DOCUMENTS PREPARATION AND TRANSMITTAL OF DOCUMENTS GENERALLY § 18.1 Original and copies... agency submitting a document to be filed and published in the Federal Register shall send an original and...