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Sample records for replicate detonation conditions

  1. Critical Initiation Conditions for Gaseous Diverging Spherical Detonations

    OpenAIRE

    Desbordes, D.

    1995-01-01

    The diverging spherical detonation wave in gaseous explosives is obtained either with a point source of explosion of energy E or through the transmission of a plane detonation from a cylindrical tube of diameter d into a large volume. The mechanism of detonation initiation in both cases is based on the shock to detonation transition. The experimental critical conditions lead to an initiation criterion for detonation resulting from the competition between the expansion behind the leading shock...

  2. Shock wave reflection induced detonation (SWRID) under high pressure and temperature condition in closed cylinder

    Science.gov (United States)

    Wang, Z.; Qi, Y.; Liu, H.; Zhang, P.; He, X.; Wang, J.

    2016-09-01

    Super-knock is one of the major obstacles for improving power density in advanced internal combustion engines (ICE). This work studied the mechanism of super-knock initiation using a rapid compression machine that simulated conditions relevant to ICEs and provided excellent optical accessibility. Based on the high-speed images and pressure traces of the stoichiometric iso-octane/oxygen/nitrogen combustion under high-temperature and high-pressure conditions, it was observed that detonation was first initiated in the near-wall region as a result of shock wave reflection. Before detonation was initiated, the speed of the combustion wave front was less than that of the Chapman-Jouguet (C-J) detonation speed (around 1840 m/s). In the immediate vicinity of the initiation, the detonation speed was much higher than that of the C-J detonation.

  3. Replicating Cardiovascular Condition-Birth Month Associations

    Science.gov (United States)

    Li, Li; Boland, Mary Regina; Miotto, Riccardo; Tatonetti, Nicholas P.; Dudley, Joel T.

    2016-01-01

    Independent replication is vital for study findings drawn from Electronic Health Records (EHR). This replication study evaluates the relationship between seasonal effects at birth and lifetime cardiovascular condition risk. We performed a Season-wide Association Study on 1,169,599 patients from Mount Sinai Hospital (MSH) to compute phenome-wide associations between birth month and CVD. We then evaluated if seasonal patterns found at MSH matched those reported at Columbia University Medical Center. Coronary arteriosclerosis, essential hypertension, angina, and pre-infarction syndrome passed phenome-wide significance and their seasonal patterns matched those previously reported. Atrial fibrillation, cardiomyopathy, and chronic myocardial ischemia had consistent patterns but were not phenome-wide significant. We confirm that CVD risk peaks for those born in the late winter/early spring among the evaluated patient populations. The replication findings bolster evidence for a seasonal birth month effect in CVD. Further study is required to identify the environmental and developmental mechanisms. PMID:27624541

  4. Detonation mode and frequency analysis under high loss conditions for stoichiometric propane-oxygen

    KAUST Repository

    Jackson, Scott

    2016-03-24

    The propagation characteristics of galloping detonations were quantified with a high-time-resolution velocity diagnostic. Combustion waves were initiated in 30-m lengths of 4.1-mm inner diameter transparent tubing filled with stoichiometric propane-oxygen mixtures. Chemiluminescence from the resulting waves was imaged to determine the luminous wave front position and velocity every 83.3 μ. As the mixture initial pressure was decreased from 20 to 7 kPa, the wave was observed to become increasingly unsteady and transition from steady detonation to a galloping detonation. While wave velocities averaged over the full tube length smoothly decreased with initial pressure down to half of the Chapman-Jouguet detonation velocity (DCJ) at the quenching limit, the actual propagation mechanism was seen to be a galloping wave with a cycle period of approximately 1.0 ms, corresponding to a cycle length of 1.3-2.0 m or 317-488 tube diameters depending on the average wave speed. The long test section length of 7300 tube diameters allowed observation of up to 20 galloping cycles, allowing for statistical analysis of the wave dynamics. In the galloping regime, a bimodal velocity distribution was observed with peaks centered near 0.4 DCJ and 0.95 DCJ. Decreasing initial pressure increasingly favored the low velocity mode. Galloping frequencies ranged from 0.8 to 1.0 kHz and were insensitive to initial mixture pressure. Wave deflagration-to-detonation transition and detonation failure trajectories were found to be repeatable in a given test and also across different initial mixture pressures. The temporal duration of wave dwell at the low and high velocity modes during galloping was also quantified. It was found that the mean wave dwell duration in the low velocity mode was a weak function of initial mixture pressure, while the mean dwell time in the high velocity mode depended exponentially on initial mixture pressure. Analysis of the velocity histories using dynamical systems ideas

  5. Detonation control

    Science.gov (United States)

    Mace, Jonathan L.; Seitz, Gerald J.; Bronisz, Lawrence E.

    2016-10-25

    Detonation control modules and detonation control circuits are provided herein. A trigger input signal can cause a detonation control module to trigger a detonator. A detonation control module can include a timing circuit, a light-producing diode such as a laser diode, an optically triggered diode, and a high-voltage capacitor. The trigger input signal can activate the timing circuit. The timing circuit can control activation of the light-producing diode. Activation of the light-producing diode illuminates and activates the optically triggered diode. The optically triggered diode can be coupled between the high-voltage capacitor and the detonator. Activation of the optically triggered diode causes a power pulse to be released from the high-voltage capacitor that triggers the detonator.

  6. A summary of hydrogen-air detonation experiments

    Energy Technology Data Exchange (ETDEWEB)

    Guirao, C.M.; Knystautas, R.; Lee, J.H.

    1989-05-01

    Dynamic detonation parameters are reviewed for hydrogen-air-diluent detonations and deflagration-to-detonation transitions (DDT). These parameters include the characteristic chemical length scale, such as the detonation cell width, associated with the three-dimensional cellular structure of detonation waves, critical transmission conditions of confined detonations into unconfined environments, critical initiation energy for unconfined detonations, detonability limits, and critical conditions for DDT. The detonation cell width, which depends on hydrogen and diluent concentrations, pressure, and temperature, is an important parameter in the prediction of critical geometry-dependent conditions for the transmission of confined detonations into unconfined environments and the critical energies for the direct initiation of unconfined detonations. Detonability limits depend on both initial and boundary conditions and the limit has been defined as the onset of single head spin. Four flame propagation regimes have been identified and the criterion for DDT in a smooth tube is discussed. 108 refs., 28 figs., 5 tabs.

  7. Influence of gas detonation spraying conditions on the quality of Fe-Al intermetallic protective coatings

    Directory of Open Access Journals (Sweden)

    Senderowski C.

    2007-01-01

    Full Text Available The aim of this paper is to present generalized research results and analyses of the quality of coatings produced with self decomposing Fe-Al intermetallic powders deposited on 1045 steel in the gas detonation spraying (GDS. A number of GDS experiments has been carried out with significantly changed operational spraying parameters (the volume of the fuel gas, carrier gas, distance and the frequency of spraying which define the process energy level directly influencing the quality of the coating. On the basis of the initial results the choice of the process parameters has been made to obtain the most advantageous set of geometrical and physical-mechanical properties of the coating material and substrate. The quality of the coatings was considered by taking into account the grain morphology, chemical content, phase inhomogeneity, cohesive porosity, as well as adhesive porosity in the substrate coating joint. The coating roughness was also considered. It was found that all GDS coatings produced are built with lamellar splats which result from the GDS process transformed (changed plasticity and geometry powder particles forming the deposit. The result of the GDS spraying parameters optimization is the lack of signs of melting of the material (even in microareas while the geometry of the deposited grains is considerably changed. This phenomenon has been considered as a proof of high plasticity of the GDS formed Fe-Al intermetallic coatings.

  8. Molecular dynamics modelling of nanocarbon cluster properties under conditions close to HE detonation

    Directory of Open Access Journals (Sweden)

    Sapozhnikov F.A.

    2011-01-01

    Full Text Available We use molecular dynamics for modelling properties of carbon nanoclusters. The size of modelled carbon nanoclusters is below 5 nm, which is typical of detonation diamond nanoclusters. We have found their structural changes at P = 0 to be as follows: Diamond → Diamond core + GL-surface → sandwich-type graphite → Graphite-like liquid. In smaller clusters the transformations start at a lower temperature. Adaptive Template Analysis (ATA was used to determine the structures. We studied evaporation properties at temperatures above 5000 K. For clusters of several thousands of atoms, the simple dependence kvap ∼ e−T0/T/N1/3 (T0 is constant is quite good. It has been found out that densities of saturated vapour for clusters containing from 4000 to 8000 atoms are very close at T = 5000 K. The structure of nanoclusters was studied at nonzero pressures set by an argon environment. Calculated results suggest that the patterns for different temperatures are qualitatively similar for three pressures under study (20, 25 and 30 GPa. At T = 1000–1500 K, the initial diamond core is preserved and a thin disordered GL layer is present on the surface. At T = 2000–5000 K, graphite grains form in the sample and a thin layer of liquid is present on its surface. The sample is amorphous at 5500 K and 6000 K. The prevalence of the graphite phase at these pressures seems to come from the absence of long-range interaction in REBO-2002.

  9. Adaptation and Diversification of an RNA Replication System under Initiation- or Termination-Impaired Translational Conditions.

    Science.gov (United States)

    Mizuuchi, Ryo; Ichihashi, Norikazu; Yomo, Tetsuya

    2016-07-01

    Adaptation to various environments is a remarkable characteristic of life. Is this limited to extant complex living organisms, or is it also possible for a simpler self-replication system to adapt? In this study, we addressed this question by using a translation-coupled RNA replication system that comprised a reconstituted translation system and an RNA "genome" that encoded a replicase gene. We performed RNA replication reactions under four conditions, under which different components of translation were partly inhibited. We found that replication efficiency increased with the number of rounds of replication under all the tested conditions. The types of dominant mutations differed depending on the condition, thus indicating that this simple system adapted to different environments in different ways. This suggests that even a primitive self-replication system composed of a small number of genes on the early earth could have had the ability to adapt to various environments.

  10. The Influence of Initial and Boundary Conditions on Gaseous Detonation Waves.

    Science.gov (United States)

    1985-09-01

    controller. UNCLASSIFIED UNCLASSIFIED 59. Once introduced into the test volume, the fuel was mixed with initial ambient air using a multipath...agreement with the prediction. If the data of these authors are increased by an additional 10% to account for the difference in ambient pressures at DRES...i.e., w2 ;) wl). In essence, we would repeat the experiment carried out by Dabora. Havig done so, the critical condition would then be monitoreo in

  11. A Necessary Condition for Coexistence of Autocatalytic Replicators in a Prebiotic Environment

    Directory of Open Access Journals (Sweden)

    Martha A. Grover

    2013-07-01

    Full Text Available A necessary, but not sufficient, mathematical condition for the coexistence of short replicating species is presented here. The mathematical condition is obtained for a prebiotic environment, simulated as a fed-batch reactor, which combines monomer recycling, variable reaction order and a fixed monomer inlet flow with two replicator types and two monomer types. An extensive exploration of the parameter space in the model validates the robustness and efficiency of the mathematical condition, with nearly 1.7% of parameter sets meeting the condition and half of those exhibiting sustained coexistence. The results show that it is possible to generate a condition of coexistence, where two replicators sustain a linear growth simultaneously for a wide variety of chemistries, under an appropriate environment. The presence of multiple monomer types is critical to sustaining the coexistence of multiple replicator types.

  12. Numerical Optimisation in Non Reacting Conditions of the Injector Geometry for a Continuous Detonation Wave Rocket Engine

    Science.gov (United States)

    Gaillard, T.; Davidenko, D.; Dupoirieux, F.

    2015-06-01

    The paper presents the methodology and the results of a numerical study, which is aimed at the investigation and optimisation of different means of fuel and oxidizer injection adapted to rocket engines operating in the rotating detonation mode. As the simulations are achieved at the local scale of a single injection element, only one periodic pattern of the whole geometry can be calculated so that the travelling detonation waves and the associated chemical reactions can not be taken into account. Here, separate injection of fuel and oxidizer is considered because premixed injection is handicapped by the risk of upstream propagation of the detonation wave. Different associations of geometrical periodicity and symmetry are investigated for the injection elements distributed over the injector head. To analyse the injection and mixing processes, a nonreacting 3D flow is simulated using the LES approach. Performance of the studied configurations is analysed using the results on instantaneous and mean flowfields as well as by comparing the mixing efficiency and the total pressure recovery evaluated for different configurations.

  13. Standing detonation wave engine

    KAUST Repository

    Kasimov, Aslan

    2015-10-08

    A detonation engine can detonate a mixture of fuel and oxidizer within a cylindrical detonation region to produce work. The detonation engine can have a first and a second inlet having ends fluidly connected from tanks to the detonation engine. The first and second inlets can be aligned along a common axis. The inlets can be connected to nozzles and a separator can be positioned between the nozzles and along the common axis.

  14. Far Field Modeling Methods For Characterizing Surface Detonations

    Energy Technology Data Exchange (ETDEWEB)

    Garrett, A. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-10-08

    Savannah River National Laboratory (SRNL) analyzed particle samples collected during experiments that were designed to replicate tests of nuclear weapons components that involve detonation of high explosives (HE). SRNL collected the particle samples in the HE debris cloud using innovative rocket propelled samplers. SRNL used scanning electronic microscopy to determine the elemental constituents of the particles and their size distributions. Depleted uranium composed about 7% of the particle contents. SRNL used the particle size distributions and elemental composition to perform transport calculations that indicate in many terrains and atmospheric conditions the uranium bearing particles will be transported long distances downwind. This research established that HE tests specific to nuclear proliferation should be detectable at long downwind distances by sampling airborne particles created by the test detonations.

  15. Initiation of the Detonation in the Gravitationally Confined Detonation Model of Type Ia Supernovae

    Science.gov (United States)

    Seitenzahl, Ivo R.; Meakin, Casey A.; Lamb, Don Q.; Truran, James W.

    2009-07-01

    We study the initiation of the detonation in the gravitationally confined detonation (GCD) model of Type Ia supernovae (SNe Ia). In this model, ignition occurs at one or several off-center points, resulting in a burning bubble of hot ash that rises rapidly, breaks through the surface of the star, and collides at a point on the stellar surface opposite the breakout, producing a high-velocity inwardly directed flow. Initiation of the detonation occurs spontaneously in a region where the length scale of the temperature gradient extending from the flow (in which carbon burning is already occurring) into unburned fuel is commensurate to the range of critical length scales which have been derived from one-dimensional simulations that resolve the initiation of a detonation. By increasing the maximum resolution in a truncated cone that encompasses this region, beginning somewhat before initiation of the detonation occurs, we successfully simulate in situ the first gradient-initiated detonation in a whole-star simulation. The detonation emerges when a compression wave overruns a pocket of fuel situated in a Kelvin-Helmholtz cusp at the leading edge of the inwardly directed jet of burning carbon. The compression wave preconditions the temperature in the fuel in such a way that the Zel'dovich gradient mechanism can operate and a detonation ensues. We explore the dependence of the length scale of the temperature gradient on spatial resolution and discuss the implications for the robustness of this detonation mechanism. We find that the time and the location at which initiation of the detonation occurs varies with resolution. In particular, initiation of a detonation had not yet occurred in our highest resolution simulation by the time we ended the simulation because of the computational demand it required. However, it may detonate later. We suggest that the turbulent shear layer surrounding the inwardly directed jet provides the most favorable physical conditions, and

  16. Nanocarbon condensation in detonation

    Science.gov (United States)

    Bastea, Sorin

    2017-01-01

    We analyze the definition of the Gibbs free energy of a nanoparticle in a reactive fluid environment, and propose an approach for predicting the size of carbon nanoparticles produced by the detonation of carbon-rich explosives that regards their condensation as a nucleation process and takes into account absolute entropy effects of the cluster population. The results are consistent with experimental observations and indicate that such entropy considerations are important for determining chemical equilibrium states in energetic materials that contain an excess of carbon. The analysis may be useful for other applications that deal with the nucleation of nanoparticles under reactive conditions. PMID:28176827

  17. Confined Detonations and Pulse Detonation Engines

    Science.gov (United States)

    2003-01-01

    Naval Ordnance Test Station. NAVWEPS Report 7655. China Lake, CA. 7. Helman, D., R. P. Shreeve, and S. Eidelman. 1986. Detonation pulse engine. AIAA...chemical presensitisation on the initiation of the detonation wave. Acta Physicochimica URSS 7:589-96. 22. Fernandez, R., J. W. Slater, and D.E. Paxson

  18. Pulse Detonation Assessment for Alternative Fuels

    Directory of Open Access Journals (Sweden)

    Muhammad Hanafi Azami

    2017-03-01

    Full Text Available The higher thermodynamic efficiency inherent in a detonation combustion based engine has already led to considerable interest in the development of wave rotor, pulse detonation, and rotating detonation engine configurations as alternative technologies offering improved performance for the next generation of aerospace propulsion systems, but it is now important to consider their emissions also. To assess both performance and emissions, this paper focuses on the feasibility of using alternative fuels in detonation combustion. Thus, the standard aviation fuels Jet-A, Acetylene, Jatropha Bio-synthetic Paraffinic Kerosene, Camelina Bio-synthetic Paraffinic Kerosene, Algal Biofuel, and Microalgae Biofuel are all asessed under detonation combustion conditions. An analytical model accounting for the Rankine-Hugoniot Equation, Rayleigh Line Equation, and Zel’dovich–von Neumann–Doering model, and taking into account single step chemistry and thermophysical properties for a stoichiometric mixture, is applied to a simple detonation tube test case configuration. The computed pressure rise and detonation velocity are shown to be in good agreement with published literature. Additional computations examine the effects of initial pressure, temperature, and mass flux on the physical properties of the flow. The results indicate that alternative fuels require higher initial mass flux and temperature to detonate. The benefits of alternative fuels appear significant.

  19. Slurry Erosion Performance Study of Detonation Gun-Sprayed WC-10Co-4Cr Coatings on CF8M Steel Under Hydro-Accelerated Conditions

    Science.gov (United States)

    Bhandari, Sanjeev; Singh, Harpreet; Kumar, Harmesh; Rastogi, Vikas

    2012-09-01

    In the current investigation, cermet coatings (WC-10Co-4Cr) were deposited on CF8M steel by detonation gun (D-gun) thermal spraying process. Subsequently, the slurry erosion behaviors of the coated and bare steels were investigated using a high-speed erosion test rig. Slurry collected from an actual hydro power plant was used as the abrasive media. Effects of concentration (ppm), average particle sizes and rotational speed on the slurry erosion behaviors of coated and bare steels under different experimental conditions were studied. The analysis of eroded samples was done using SEM and stylus profilometry. Signatures of microcutting, fracture of well-bonded WC grains, and fragmentations were observed on the eroded surface of WC-10Co-4Cr coating, while signatures of formation of plowing, lips, shearing of platelet, formation of crater, and micro-cutting were observed on the eroded surface of CF8M steel.

  20. Detonation Wave Profile

    Energy Technology Data Exchange (ETDEWEB)

    Menikoff, Ralph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-12-14

    The Zel’dovich-von Neumann-Doering (ZND) profile of a detonation wave is derived. Two basic assumptions are required: i. An equation of state (EOS) for a partly burned explosive; P(V, e, λ). ii. A burn rate for the reaction progress variable; d/dt λ = R(V, e, λ). For a steady planar detonation wave the reactive flow PDEs can be reduced to ODEs. The detonation wave profile can be determined from an ODE plus algebraic equations for points on the partly burned detonation loci with a specified wave speed. Furthermore, for the CJ detonation speed the end of the reaction zone is sonic. A solution to the reactive flow equations can be constructed with a rarefaction wave following the detonation wave profile. This corresponds to an underdriven detonation wave, and the rarefaction is know as a Taylor wave.

  1. Characterization of Infectivity-Enhanced Conditionally Replicating Adenovectors for Prostate Cancer Radiovirotherapy

    OpenAIRE

    Oneal, Michael J.; Trujillo, Miguel A; Davydova, Julia; McDonough, Samantha; Yamamoto, Masato; Morris, John C.

    2012-01-01

    Prostate cancer (PCa) is the second most commonly diagnosed and sixth leading cause of cancer death in American men and one for which no curative therapy exists after metastasis. To meet this need for novel therapies, our laboratory has previously generated conditionally replicating adenovirus (CRAd) vectors expressing the sodium iodide symporter (hNIS). This virus transduced PCa cells and induced functional NIS expression, allowing for noninvasive tumor imaging and combination therapy with r...

  2. Turbulent deflagrations, autoignitions, and detonations

    KAUST Repository

    Bradley, Derek

    2012-09-01

    Measurements of turbulent burning velocities in fan-stirred explosion bombs show an initial linear increase with the fan speed and RMS turbulent velocity. The line then bends over to form a plateau of high values around the maximum attainable burning velocity. A further increase in fan speed leads to the eventual complete quenching of the flame due to increasing localised extinctions because of the flame stretch rate. The greater the Markstein number, the more readily does flame quenching occur. Flame propagation along a duct closed at one end, with and without baffles to increase the turbulence, is subjected to a one-dimensional analysis. The flame, initiated at the closed end of the long duct, accelerates by the turbulent feedback mechanism, creating a shock wave ahead of it, until the maximum turbulent burning velocity for the mixture is attained. With the confining walls, the mixture is compressed between the flame and the shock plane up to the point where it might autoignite. This can be followed by a deflagration to detonation transition. The maximum shock intensity occurs with the maximum attainable turbulent burning velocity, and this defines the limit for autoignition of the mixture. For more reactive mixtures, autoignition can occur at turbulent burning velocities that are less than the maximum attainable one. Autoignition can be followed by quasi-detonation or fully developed detonation. The stability of ensuing detonations is discussed, along with the conditions that may lead to their extinction. © 2012 by Pleiades Publishing, Ltd.

  3. Sensitized Liquid Hydrazine Detonation Studies

    Science.gov (United States)

    Rathgeber, K. A.; Keddy, C. P.; Bunker, R. L.

    1999-01-01

    Vapor-phase hydrazine (N2H4) is known to be very sensitive to detonation while liquid hydrazine is very insensitive to detonation, theoretically requiring extremely high pressures to induce initiation. A review of literature on solid and liquid explosives shows that when pure explosive substances are infiltrated with gas cavities, voids, and/or different phase contaminants, the energy or shock pressure necessary to induce detonation can decrease by an order of magnitude. Tests were conducted with liquid hydrazine in a modified card-gap configuration. Sensitization was attempted by bubbling helium gas through and/or suspending ceramic microspheres in the liquid. The hydrazine was subjected to the shock pressure from a 2 lb (0.9 kg) Composition C-4 explosive charge. The hydrazine was contained in a 4 in. (10.2 cm) diameter stainless steel cylinder with a 122 in(sup 3) (2 L) volume and sealed with a polyethylene cap. Blast pressures from the events were recorded by 63 high speed pressure transducers located on three radial legs extending from 4 to 115 ft (1.2 to 35.1 in) from ground zero. Comparison of the neat hydrazine and water baseline tests with the "sensitized" hydrazine tests indicates the liquid hydrazine did not detonate under these conditions.

  4. Detonation command and control

    Science.gov (United States)

    Mace, Jonathan L.; Seitz, Gerald J.; Echave, John A.; Le Bas, Pierre-Yves

    2015-11-10

    The detonation of one or more explosive charges and propellant charges by a detonator in response to a fire control signal from a command and control system comprised of a command center and instrumentation center with a communications link therebetween. The fire control signal is selectively provided to the detonator from the instrumentation center if plural detonation control switches at the command center are in a fire authorization status, and instruments, and one or more interlocks, if included, are in a ready for firing status. The instrumentation and command centers are desirably mobile, such as being respective vehicles.

  5. Detonation command and control

    Energy Technology Data Exchange (ETDEWEB)

    Mace, Jonathan L.; Seitz, Gerald J.; Echave, John A.; Le Bas, Pierre-Yves

    2016-05-31

    The detonation of one or more explosive charges and propellant charges by a detonator in response to a fire control signal from a command and control system comprised of a command center and instrumentation center with a communications link there between. The fire control signal is selectively provided to the detonator from the instrumentation center if plural detonation control switches at the command center are in a fire authorization status, and instruments, and one or more interlocks, if included, are in a ready for firing status. The instrumentation and command centers are desirably mobile, such as being respective vehicles.

  6. Transient heat transfer properties in a pulse detonation combustor

    OpenAIRE

    Fontenot, Dion G.

    2011-01-01

    Approved for public release; distribution is unlimited. The heat transfer along the axis of a pulse detonation combustor has been characterized for various frequencies and fill fractions at 2.5 atmospheres of pressure for chamber refresh conditions. In a pulse detonation combustor, a supersonic detonation wave is the method for transforming chemical energy into mechanical energy and the wave propagates much faster than the subsonic flames in devices such as rockets and ramjets. The flow...

  7. Study on Premixed Gas Detonation Wave Propagation under Different Initial Conditions%不同初始条件下预混气体爆轰波传播研究

    Institute of Scientific and Technical Information of China (English)

    曲忠伟; 林谋金

    2013-01-01

    为了研究预混气体爆轰波的传播速度与初始压力、温度、预混气体密度等因素之间的关系,首先分析了丙烷和空气的混合气体爆轰波的传播速度与各影响因素的关系,利用自制的方形激波管,通过实验测试了预混气体的爆轰波传播特性,然后采用定性矩阵的分析手段来定性分析各个初始条件对爆轰波传播速度的影响,结合定量的实验和定性的分析可以看出,预混气体爆轰波的传播速度与初始条件(ρ、T、C、P)之间定量的影响结果和定性的分析是一致的。该手段验证了实验结果,为研究未知初始条件的影响提供了一种方法,对于爆轰波传播机理的深入研究具有重要意义。%In order to study relationship among premixed gas detonation wave propagation velocity and the initial pressure , temperature , premixed gas density and other factors ,relationship among propane , oxygen and air mixed gas detonation wave propagation velocity and each factor was firstly analyzed .The premixed gas detonation wave propagation characteristics were tested by experiment using home -made square shock tube , and then influence of various initial conditions (ρ、T、C、P ) on propagation velocity of detonation was qualitatively analyzed using qualitative matrix .On the basis of quantitative experiments and qualitative analysis , it was showed that the quali-tative result of the premixed gas detonation wave propagation velocity and the initial conditions is consistent with qualitative analysis .The method validated the experimental results , providing a reference to study of influnece of unknown initial conditions , which has important significance for detonation wave propagation mechanism study in deep.

  8. Model of non-ideal detonation of condensed high explosives

    Science.gov (United States)

    Smirnov, E. B.; Kostitsin, O. V.; Koval, A. V.; Akhlyustin, I. A.

    2016-11-01

    The Zeldovich-Neumann-Doering theory of ideal detonation allows one to describe adequately the detonation of charges with near-critical diameter. For smaller diameters, detonation velocity can differ significantly from an ideal value expected based on equilibrium chemical thermodynamics. This difference is quite evident when using non-ideal explosives; in certain cases, this value can be up to one third of ideal detonation velocity. Numerical simulation of these systems is a very labor-consuming process because one needs to compute the states inside the chemical reaction zone, as well as to obtain data on the equation of state of high-explosive detonation products mixture and on the velocity of chemical reaction; however, these characteristics are poorly studied today. For practical purposes, one can use the detonation shock dynamics model based on interrelation between local velocity of the front and its local curvature. This interrelation depends on both the equation of state of explosion products, and the reaction velocity; but the explicit definition of these characteristics is not needed. In this paper, experimental results are analyzed. They demonstrate interrelation between the local curvature of detonation front and the detonation velocity. Equation of detonation front shape is found. This equation allows us to predict detonation velocity and shape of detonation wave front in arbitrary geometry by integrating ordinary differential equation for the front shape with a boundary condition at the charge edge. The results confirm that the model of detonation shock dynamics can be used to describe detonation processes in non-ideal explosives.

  9. Initiation of the detonation in the gravitationally confined detonation model of Type Ia supernovae

    CERN Document Server

    Seitenzahl, Ivo R; Lamb, Don Q; Truran, James W

    2009-01-01

    We study the initiation of the detonation in the gravitationally confined detonation (GCD) model of Type Ia supernovae (SNe Ia). Initiation of the detonation occurs spontaneously in a region where the length scale of the temperature gradient extending from a flow (in which carbon burning is already occurring) into unburned fuel is commensurate to the range of critical length scales which have been derived from 1D simulations that resolve the initiation of a detonation. By increasing the maximum resolution in a truncated cone that encompasses this region, beginning somewhat before initiation of the detonation occurs, we successfully simulate in situ the first gradient-initiated detonation in a whole-star simulation. The detonation emerges when a compression wave overruns a pocket of fuel situated in a Kelvin-Helmholtz cusp at the leading edge of the inwardly directed jet of burning carbon. The compression wave pre-conditions the temperature in the fuel in such a way that the Zel'dovich gradient mechanism can o...

  10. Detonability of white dwarf plasma: turbulence models at low densities

    Science.gov (United States)

    Fenn, D.; Plewa, T.

    2017-06-01

    We study the conditions required to produce self-sustained detonations in turbulent, carbon-oxygen degenerate plasma at low densities. We perform a series of three-dimensional hydrodynamic simulations of turbulence driven with various degrees of compressibility. The average conditions in the simulations are representative of models of merging binary white dwarfs. We find that material with very short ignition times is abundant in case turbulence is driven compressively. This material forms contiguous structures that persist over many ignition times, and that we identify as prospective detonation kernels. Detailed analysis of prospective kernels reveals that these objects are centrally condensed and their shape is characterized by low curvature, supportive of self-sustained detonations. The key characteristic of the newly proposed detonation mechanism is thus high degree of compressibility of turbulent drive. The simulated detonation kernels have sizes notably smaller than the spatial resolution of any white dwarf merger simulation performed to date. The resolution required to resolve kernels is 0.1 km. Our results indicate a high probability of detonations in such well-resolved simulations of carbon-oxygen white dwarf mergers. These simulations will likely produce detonations in systems of lower total mass, thus broadening the population of white dwarf binaries capable of producing Type Ia supernovae. Consequently, we expect a downward revision of the lower limit of the total merger mass that is capable of producing a prompt detonation. We review application of the new detonation mechanism to various explosion scenarios of single, Chandrasekhar-mass white dwarfs.

  11. Conditionally replicating adenovirus prevents pluripotent stem cell–derived teratoma by specifically eliminating undifferentiated cells

    Directory of Open Access Journals (Sweden)

    Kaoru Mitsui

    2015-01-01

    Full Text Available Incomplete abolition of tumorigenicity creates potential safety concerns in clinical trials of regenerative medicine based on human pluripotent stem cells (hPSCs. Here, we demonstrate that conditionally replicating adenoviruses that specifically target cancers using multiple factors (m-CRAs, originally developed as anticancer drugs, may also be useful as novel antitumorigenic agents in hPSC-based therapy. The survivin promoter was more active in undifferentiated hPSCs than the telomerase reverse transcriptase (TERT promoter, whereas both promoters were minimally active in differentiated normal cells. Accordingly, survivin-responsive m-CRA (Surv.m-CRA killed undifferentiated hPSCs more efficiently than TERT-responsive m-CRAs (Tert.m-CRA; both m-CRAs exhibited efficient viral replication and cytotoxicity in undifferentiated hPSCs, but not in cocultured differentiated normal cells. Pre-infection of hPSCs with Surv.m-CRA or Tert.m-CRA abolished in vivo teratoma formation in a dose-dependent manner following hPSC implantation into mice. Thus, m-CRAs, and in particular Surv.m-CRAs, represent novel antitumorigenic agents that could facilitate safe clinical applications of hPSC-based regenerative medicine.

  12. Application of conditionally replicating adenoviruses in tumor early diagnosis technology, gene-radiation therapy and chemotherapy.

    Science.gov (United States)

    Li, Shun; Ou, Mengting; Wang, Guixue; Tang, Liling

    2016-10-01

    Conditionally replicating adenoviruses (CRAds), or known as replication-selective adenoviruses, were discovered as oncolytic gene vectors several years ago. They have a strong ability of scavenging tumor and lesser toxicity to normal tissue. CRAds not only have a tumor-killing ability but also can combine with gene therapy, radiotherapy, and chemotherapy to induce tumor cell apoptosis. In this paper, we review the structure of CRAds and CRAd vectors and summarize the current application of CRAds in tumor detection as well as in radiotherapy and suicide gene-mediating chemotherapy. We also propose further research strategies that can improve the application value of CRAds, including enhancing tumor destruction effect, further reducing toxic effect, reducing immunogenicity, constructing CRAds that can target tumor stem cells, and trying to use mesenchymal stem cells (MSCs) as the carriers for oncolytic adenoviruses. As their importance to cancer diagnosis, gene-radiation, and chemotherapy, CRAds may play a considerable role in clinical diagnosis and various cancer treatments in the future.

  13. Pulsating reverse detonation models of Type Ia supernovae. I. Detonation ignition

    OpenAIRE

    Bravo Guil, Eduardo; García Senz, Domingo

    2009-01-01

    Observational evidences point to a common explosion mechanism of Type Ia supernovae based on a delayed detonation of a white dwarf. Although several scenarios have been proposed and explored by means of one, two, and three-dimensional simulations, the key point still is the understanding of the conditions under which a stable detonation can form in a destabilized white dwarf. One of the possibilities that have been invoked is that an inefficient deflagration leads to the pulsation of a Chandr...

  14. Detonation safety of blasting caps

    Institute of Scientific and Technical Information of China (English)

    谢兴华; 彭小圣

    2002-01-01

    By means of researching into sympathetic detonation of blasting detonators in air, the regular patterns are concluded from blasting detonators interaction with the shock loading. The aerial distribution of initiating ability of detonators looks like a butterfly. The initiating ability mainly consists of shock wave, explosive gases and fliers. But fundamental questions remain. When does shock wave take the leading role? When and how does the explosive gases or the fliers take function? For those questions, there is less quantitative research. Through the theoretic deduction of the overpressure, the energy calculation of fliers and the experiment of sympathetic detonation of detonators, we can learn the sympathetic detonation distances of several kinds of detonators and make an inquiry into the lateral initiating regulations of detonators. So, we can provide the base data for the research into no sympathetic detonation of herd blasting detonators and then control the detonation between them. Then we can make full use of detonators and reduce the frequency of accidents caused by detonators.

  15. shRNA-armed conditionally replicative adenoviruses: a promising approach for cancer therapy

    Science.gov (United States)

    Zhang, Jie; Ding, Meng; Xu, Kai; Mao, Lijun; Zheng, Junian

    2016-01-01

    The small-interfering RNAs (siRNAs) have been employed to knockdown the expression of cancer-associated genes and shown some promise in cancer therapy. However, synthetic siRNA duplexes or plasmid mediated delivery of siRNAs have several problems, such as short half-life, low transfection efficiency and cytotoxicity associated with transfection. Conditionally replicating adenovirus (CRAds) as the delivery vector for short hairpin RNAs (shRNAs) could overcome these limitations and have shown augmented anti-tumor effects in experimental studies and preclinical trials. In this review, we summarize recent progress in the development of CRAds-shRNA for cancer treatment. Combination of CRAds-shRNA with chemotherapeutics, radiation, dendritic cells, monoclonal antibodies and small-molecule inhibitors will be necessary to eradicate cancer cells and cancer stem cells and achieve superior outcomes. The use of CRAd platform for efficient delivery of shRNAs and foreign genes will open a new avenue for cancer therapy. PMID:26980708

  16. Type Ia Supernova Explosion: Gravitationally Confined Detonation

    CERN Document Server

    Plewa, T; Lamb, D

    2004-01-01

    We present a new mechanism for Type Ia supernova explosions in massive white dwarfs. The proposed scenario follows from relaxing the assumption of symmetry in the model and involves a detonation created in an unconfined environment. The explosion begins with an essentially central ignition of stellar material initiating a deflagration. This deflagration results in the formation of a buoyantly-driven bubble of hot material that reaches the stellar surface at supersonic speeds. The bubble breakout forms a strong pressure wave that laterally accelerates fuel-rich outer stellar layers. This material, confined by gravity to the white dwarf, races along the stellar surface and is focused at the location opposite to the point of the bubble breakout. These streams of nuclear fuel carry enough mass and energy to trigger a detonation just above the stellar surface. The flow conditions at that moment support a detonation that will incinerate the white dwarf and result in an energetic explosion. The stellar expansion fol...

  17. Detonations and deflagrations in cosmological phase transitions

    CERN Document Server

    Megevand, Ariel

    2009-01-01

    We study the steady state motion of bubble walls in cosmological phase transitions. Taking into account the boundary and continuity conditions for the fluid variables, we calculate numerically the wall velocity as a function of the nucleation temperature, the latent heat, and a friction parameter. We determine regions in the space of these parameters in which detonations and/or deflagrations are allowed. In order to apply the results to a physical case, we calculate these quantities in a specific model, which consists of an extension of the Standard Model with singlet scalar fields. We also obtain analytic approximations for deflagrations and detonations.

  18. Effect of prill structure on detonation performance of ANFO

    Energy Technology Data Exchange (ETDEWEB)

    Salyer, Terry R [Los Alamos National Laboratory; Short, Mark [Los Alamos National Laboratory; Kiyanda, Charles B [Los Alamos National Laboratory; Morris, John S [Los Alamos National Laboratory; Zimmerly, Tony [EMRTC NMT

    2010-01-01

    While the effects of charge diameter, fuel mix ratio, and temperature on ANFO detonation performance are substantial, the effects of prill type are considerable as well as tailorable. Engineered AN prills provide a means to improve overall performance, primarily by changing the material microstructure through the addition of features designed to enhance hot spot action. To examine the effects of prill type (along with fuel mix ratio and charge diameter) on detonation performance, a series of precision, large-scale, ANFO front-curvature rate-stick tests was performed. Each shot used standard No. 2 diesel for the fuel oil and was essentially unconfined with cardboard confinement. Detonation velocities and front curvatures were measured while actively maintaining consistent shot temperatures. Based on the experimental results, DSD calibrations were performed to model the detonation performance over a range of conditions, and the overall effects of prill microstructure were examined and correlated with detonation performance.

  19. Environmentally Benign Stab Detonators

    Energy Technology Data Exchange (ETDEWEB)

    Gash, A

    2005-12-21

    Many energetic systems can be activated via mechanical means. Percussion primers in small caliber ammunition and stab detonators used in medium caliber ammunition are just two examples. Current medium caliber (20-60mm) munitions are detonated through the use of impact sensitive stab detonators. Stab detonators are very sensitive and must be small, as to meet weight and size limitations. A mix of energetic powders, sensitive to mechanical stimulus, is typically used to ignite such devices. Stab detonators are mechanically activated by forcing a firing pin through the closure disc of the device and into the stab initiating mix. Rapid heating caused by mechanically driven compression and friction of the mixture results in its ignition. The rapid decomposition of these materials generates a pressure/temperature pulse that is sufficient to initiate a transfer charge, which has enough output energy to detonate the main charge. This general type of ignition mix is used in a large variety of primers, igniters, and detonators.[1] Common primer mixes, such as NOL-130, are made up of lead styphnate (basic) 40%, lead azide (dextrinated) 20%, barium nitrate 20%, antimony sulfide 15%, and tetrazene 5%.[1] These materials pose acute and chronic toxicity hazards during mixing of the composition and later in the item life cycle after the item has been field functioned. There is an established need to replace these mixes on toxicity, health, and environmental hazard grounds. This effort attempts to demonstrate that environmentally acceptable energetic solgel coated flash metal multilayer nanocomposites can be used to replace current impact initiated devices (IIDs), which have hazardous and toxic components. Successful completion of this project will result in IIDs that include innocuous compounds, have sufficient output energy for initiation, meet current military specifications, are small, cost competitive, and perform as well as or better than current devices. We expect flash

  20. Numerical study of nonequilibrium plasma assisted detonation initiation in detonation tube

    Science.gov (United States)

    Zhou, Siyin; Wang, Fang; Che, Xueke; Nie, Wansheng

    2016-12-01

    Nonequilibrium plasma has shown great merits in ignition and combustion nowadays, which should be especially useful for hypersonic propulsion. A coaxial electrodes configuration was established to investigate the effect of alternating current (AC) dielectric barrier discharge nonequilibrium plasma on the detonation initiation process in a hydrogen-oxygen mixture. A discharge simulation-combustion simulation loosely coupled method was used to simulate plasma assisted detonation initiation. First, the dielectric barrier discharge in the hydrogen-oxygen mixture driven by an AC voltage was simulated, which takes 17 kinds of particles (including positively charged particles, negatively charged particles, and neutral particles) and 47 reactions into account. The temporal and spatial characteristics of the discharge products were obtained. Then, the discharge products were incorporated into the combustion model of a detonation combustor as the initial conditions for the later detonation initiation simulation. Results showed that the number density distributions of plasma species are different in space and time, and develop highly nonuniformly from high voltage electrode to grounded electrode at certain times. All the active species reach their highest concentration at approximately 0.6T (T denotes a discharge cycle). Compared with the no plasma case, the differences of flowfield shape mainly appear in the early stage of the deflagration to detonation transition process. None of the sub-processes (including the very slow combustion, deflagration, over-driven detonation, detonation decay, and propagation of a self-sustained stable detonation wave) have been removed by the plasma. After the formation of a C-J detonation wave, the whole flowfield remains unchanged. With the help of plasma, the deflagration to detonation transition (DDT) time and distance are reduced by about 11.6% and 12.9%, respectively, which should be attributed to the active particles effect of

  1. Detonation Jet Engine. Part 2--Construction Features

    Science.gov (United States)

    Bulat, Pavel V.; Volkov, Konstantin N.

    2016-01-01

    We present the most relevant works on jet engine design that utilize thermodynamic cycle of detonative combustion. Detonation engines of various concepts, pulse detonation, rotational and engine with stationary detonation wave, are reviewed. Main trends in detonation engine development are discussed. The most important works that carried out…

  2. Pulsating reverse detonation models of Type Ia supernovae. I: Detonation ignition

    CERN Document Server

    Bravo, Eduardo

    2009-01-01

    Observational evidences point to a common explosion mechanism of Type Ia supernovae based on a delayed detonation of a white dwarf. Although several scenarios have been proposed and explored by means of one, two, and three-dimensional simulations, the key point still is the understanding of the conditions under which a stable detonation can form in a destabilized white dwarf. One of the possibilities that have been invoked is that an inefficient deflagration leads to the pulsation of a Chandrasekhar-mass white dwarf, followed by formation of an accretion shock around a carbon-oxygen rich core. The accretion shock confines the core and transforms kinetic energy from the collapsing halo into thermal energy of the core, until an inward moving detonation is formed. This chain of events has been termed Pulsating Reverse Detonation (PRD). In this work we explore the robustness of the detonation ignition for different PRD models characterized by the amount of mass burned during the deflagration phase, M_defl. The ev...

  3. THE DETONATION MECHANISM OF THE PULSATIONALLY ASSISTED GRAVITATIONALLY CONFINED DETONATION MODEL OF Type Ia SUPERNOVAE

    Energy Technology Data Exchange (ETDEWEB)

    Jordan, G. C. IV; Graziani, C.; Weide, K.; Norris, J.; Hudson, R.; Lamb, D. Q. [Flash Center for Computational Science, University of Chicago, Chicago, IL 60637 (United States); Fisher, R. T. [Department of Physics, University of Massachusetts Dartmouth, 285 Old Westport Road, North Dartmouth, MA 02740 (United States); Townsley, D. M. [Department of Physics and Astronomy, University of Alabama, Tuscaloosa, AL 35487 (United States); Meakin, C. [Steward Observatory, University of Arizona, Tucson, AZ 85721 (United States); Reid, L. B. [NTEC Environmental Technology, Subiaco WA 6008 (Australia)

    2012-11-01

    We describe the detonation mechanism composing the 'pulsationally assisted' gravitationally confined detonation (GCD) model of Type Ia supernovae. This model is analogous to the previous GCD model reported in Jordan et al.; however, the chosen initial conditions produce a substantively different detonation mechanism, resulting from a larger energy release during the deflagration phase. The resulting final kinetic energy and {sup 56}Ni yields conform better to observational values than is the case for the 'classical' GCD models. In the present class of models, the ignition of a deflagration phase leads to a rising, burning plume of ash. The ash breaks out of the surface of the white dwarf, flows laterally around the star, and converges on the collision region at the antipodal point from where it broke out. The amount of energy released during the deflagration phase is enough to cause the star to rapidly expand, so that when the ash reaches the antipodal point, the surface density is too low to initiate a detonation. Instead, as the ash flows into the collision region (while mixing with surface fuel), the star reaches its maximally expanded state and then contracts. The stellar contraction acts to increase the density of the star, including the density in the collision region. This both raises the temperature and density of the fuel-ash mixture in the collision region and ultimately leads to thermodynamic conditions that are necessary for the Zel'dovich gradient mechanism to produce a detonation. We demonstrate feasibility of this scenario with three three-dimensional (3D), full star simulations of this model using the FLASH code. We characterized the simulations by the energy released during the deflagration phase, which ranged from 38% to 78% of the white dwarf's binding energy. We show that the necessary conditions for detonation are achieved in all three of the models.

  4. The Detonation Mechanism of the Pulsationally Assisted Gravitationally Confined Detonation Model of Type Ia Supernovae

    Science.gov (United States)

    Jordan, G. C., IV; Graziani, C.; Fisher, R. T.; Townsley, D. M.; Meakin, C.; Weide, K.; Reid, L. B.; Norris, J.; Hudson, R.; Lamb, D. Q.

    2012-11-01

    We describe the detonation mechanism composing the "pulsationally assisted" gravitationally confined detonation (GCD) model of Type Ia supernovae. This model is analogous to the previous GCD model reported in Jordan et al.; however, the chosen initial conditions produce a substantively different detonation mechanism, resulting from a larger energy release during the deflagration phase. The resulting final kinetic energy and 56Ni yields conform better to observational values than is the case for the "classical" GCD models. In the present class of models, the ignition of a deflagration phase leads to a rising, burning plume of ash. The ash breaks out of the surface of the white dwarf, flows laterally around the star, and converges on the collision region at the antipodal point from where it broke out. The amount of energy released during the deflagration phase is enough to cause the star to rapidly expand, so that when the ash reaches the antipodal point, the surface density is too low to initiate a detonation. Instead, as the ash flows into the collision region (while mixing with surface fuel), the star reaches its maximally expanded state and then contracts. The stellar contraction acts to increase the density of the star, including the density in the collision region. This both raises the temperature and density of the fuel-ash mixture in the collision region and ultimately leads to thermodynamic conditions that are necessary for the Zel'dovich gradient mechanism to produce a detonation. We demonstrate feasibility of this scenario with three three-dimensional (3D), full star simulations of this model using the FLASH code. We characterized the simulations by the energy released during the deflagration phase, which ranged from 38% to 78% of the white dwarf's binding energy. We show that the necessary conditions for detonation are achieved in all three of the models.

  5. Environmentally Benign Stab Detonators

    Science.gov (United States)

    2006-07-11

    a mixture of lead azide, lead styphnate , barium nitrate, antimony sulfides, and tetracene) mJ millijoule (10–3 J) FINAL REPORT PP...initiating mix (NOL-130) and transfer charge of current stab detonators contain hazardous materials such as lead azide, lead styphnate , and barium nitrate...tetracene) and heavy metal constituents (e.g., lead styphnate , lead azide, barium nitrate, and antimony sulfides) present in the NOL-130 initiating

  6. ABOUT THE DETONATION ENGINE

    Directory of Open Access Journals (Sweden)

    Bulat Pavel Viktorovich

    2014-01-01

    Full Text Available The research objects of this study are new principles of gas turbine and rocket engines working process organization, based on the oscillatory motion of shock and detonation waves. Purpose is to identify the state of level technology, describe the subject area, state the direction of research and formulate the main problems hindering the implementation of wave technology into mass production. The results presented in the study can be recommended for developers of aircraft engines, power and technological turbo-machinery.

  7. Detonation propagation in a high loss configuration

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, Scott I [Los Alamos National Laboratory; Shepherd, Joseph E [CALTECH

    2009-01-01

    This work presents an experimental study of detonation wave propagation in tubes with inner diameters (ID) comparable to the mixture cell size. Propane-oxygen mixtures were used in two test section tubes with inner diameters of 1.27 mm and 6.35 mm. For both test sections, the initial pressure of stoichiometric mixtures was varied to determine the effect on detonation propagation. For the 6.35 mm tube, the equivalence ratio {phi} (where the mixture was {phi} C{sub 3}H{sub 8} + 50{sub 2}) was also varied. Detonations were found to propagate in mixtures with cell sizes as large as five times the diameter of the tube. However, under these conditions, significant losses were observed, resulting in wave propagation velocities as slow as 40% of the CJ velocity U{sub CJ}. A review of relevant literature is presented, followed by experimental details and data. Observed velocity deficits are predicted using models that account for boundary layer growth inside detonation waves.

  8. Detonation Properties of Bromonitromethane

    Science.gov (United States)

    Davis, Lloyd L.; Sheffield, Stephen A.; Engelke, Ray

    1999-06-01

    Bromonitromethane (CH_2BrNO_2)(BrNM) is chemically similar to nitromethane (NM), with one hydrogen atom replaced by bromine. It is a liquid explosive with an initial density of 2.009 g/cm^3. We have shown its sensitivity to shock to be similar to neat NM. However, its performance (CJ pressure) appears to be about twice that of NM. The sound speed of BrNM was measured to be 1.16 km/s and was used in the Universal Liquid Hugoniot (R. W. Woolfolk, M. Cowperthwaite and R. Shaw, Thermochimica Acta, 5), 409 (1983). to predict the unreacted Hugoniot. Shock Hugoniot measurements were shown to be consistent with this prediction. In addition, we report the BrNM detonation velocity, failure diameter in brass, and diameter effect curve. Detonation wave profiles obtained using VISAR to record the interface particle velocity between the detonating BrNM and a polymethyl methacrylate (PMMA) window have also been measured. There are interesting features in these measurements that may provide information about the reactions occurring in the BrNM and/or the effect of the confinement.

  9. Vascular endothelial growth factor promoter-based conditionally replicative adenoviruses effectively suppress growth of malignant pleural mesothelioma.

    Science.gov (United States)

    Harada, Akiko; Uchino, Junji; Harada, Taishi; Nakagaki, Noriaki; Hisasue, Junko; Fujita, Masaki; Takayama, Koichi

    2017-01-01

    Malignant mesothelioma (MM) incidence is increasing drastically worldwide as an occupational disease resulting from asbestos exposure. However, no curative treatment for MM of advanced stage is available. Thus, new therapeutic approaches for MM are required. Because malignant pleural mesothelioma (MPM) cells spread along the pleural surface in most patients, MPM can be targeted using intrapleural therapeutic approaches. In this study, we investigated the effectiveness of the intrapleural instillation of a replication-competent adenovirus as an oncolytic agent against MPM. We constructed a vascular endothelial growth factor promoter-based conditionally replicative adenovirus (VEGF-CRAd) that replicates exclusively in VEGF-expressing cells. All of the MM cell lines that we tested expressed VEGF mRNA, and VEGF-CRAd selectively replicated in these MM cells and exerted a direct concentration-dependent oncolytic effect in vitro. Furthermore, our in vivo studies showed that pre-infection of MM cells with VEGF-CRAd potently suppressed MPM tumor formation in nude mice, and that intrapleural instillation of VEGF-CRAd prolonged the survival time of tumor-bearing mice. Our results indicate that VEGF-CRAd exerts an oncolytic effect on MM cells and that intrapleural instillation of VEGF-CRAd is safe and might represent a promising therapeutic strategy for MPM. © 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

  10. Simulating sympathetic detonation using the hydrodynamic models and constitutive equations

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bo Hoon; Kim, Min Sung; Yoh, Jack J. [Dept. of Mechanical and Aerospace Engineering, Seoul National University, Seoul (Korea, Republic of); Sun, Tae Boo [Hanwha Corporation Defense Rand D Center, Daejeon (Korea, Republic of)

    2016-12-15

    A Sympathetic detonation (SD) is a detonation of an explosive charge by a nearby explosion. Most of times it is unintended while the impact of blast fragments or strong shock waves from the initiating donor explosive is the cause of SD. We investigate the SD of a cylindrical explosive charge (64 % RDX, 20 % Al, 16 % HTPB) contained in a steel casing. The constitutive relations for high explosive are obtained from a thermo-chemical code that provides the size effect data without the rate stick data typically used for building the rate law and equation of state. A full size SD test of eight pallet-packaged artillery shells is performed that provides the pressure data while the hydrodynamic model with proper constitutive relations for reactive materials and the fragmentation model for steel casing is conducted to replicate the experimental findings. The work presents a novel effort to accurately model and reproduce the sympathetic detonation event with a reduced experimental effort.

  11. Semiconductor bridge (SCB) detonator

    Science.gov (United States)

    Bickes, Jr., Robert W.; Grubelich, Mark C.

    1999-01-01

    The present invention is a low-energy detonator for high-density secondary-explosive materials initiated by a semiconductor bridge igniter that comprises a pair of electrically conductive lands connected by a semiconductor bridge. The semiconductor bridge is in operational or direct contact with the explosive material, whereby current flowing through the semiconductor bridge causes initiation of the explosive material. Header wires connected to the electrically-conductive lands and electrical feed-throughs of the header posts of explosive devices, are substantially coaxial to the direction of current flow through the SCB, i.e., substantially coaxial to the SCB length.

  12. The propagation of detonation waves in non-ideal condensed-phase explosives confined by high sound-speed materials

    Science.gov (United States)

    Schoch, Stefan; Nikiforakis, Nikolaos; Lee, Bok Jik

    2013-08-01

    Highly non-ideal condensed-phase explosives used by the mining industry have a strong detonation velocity dependence on the charge dimension. Detonation velocities can be as low as one third of the theoretically calculated ideal detonation velocity in charge radii close to the failure radius. Under these detonation conditions the flow in the confiner can become subsonic, a flow condition under which classical shock-polar analysis is not applicable. This restriction prohibits the use of popular engineering models like detonation shock dynamics and Wood-Kirkwood type models under these confinement conditions. In addition, it has been found in the literature that subsonic flow in the confiner will increase the influence of the confining material on the detonation performance. In this work, we use a multi-phase model coupled to an elastic-plastic model (for the representation of a confiner) to explore the interaction of detonations under these confiner conditions. An ammonium nitrate based mining emulsion is investigated in aluminium and steel confinement of finite and infinite thickness representing the confiner as either a fluid or an elastic-plastic material. It is found that the presence of elastic waves is negligible close to ideal detonation conditions, but is important close to the failure radius and in detonation conditions with subsonic flow in the confiner. High sound-speed confiners support the detonation through energy transport ahead of the detonation front if desensitisation effects are negligible. The detonation front profiles are found to remain convex even in the most non-ideal detonation conditions, and the detonation front curvature only becomes concave in a localised region close to the confiner edge.

  13. Direct initiation of gaseous detonation via radiative heating of microparticles volumetrically suspended in the gas

    Science.gov (United States)

    Efremov, V. P.; Ivanov, M. F.; Kiverin, A. D.; Yakovenko, I. S.

    2015-11-01

    We propose a new conceptual approach for direct detonation initiation in the gaseous mixtures seeded with micro particles via the radiative heating from the external energy source. The basic mechanisms of energy absorption, ignition and detonation formation are analyzed numerically on the example of hydrogen-oxygen mixture. Obtained data is very promising and allows us to formulate conditions for the source power to ignite detonation in certain system geometry.

  14. Development and testing of pulsed and rotating detonation combustors

    Science.gov (United States)

    St. George, Andrew C.

    Detonation is a self-sustaining, supersonic, shock-driven, exothermic reaction. Detonation combustion can theoretically provide significant improvements in thermodynamic efficiency over constant pressure combustion when incorporated into existing cycles. To harness this potential performance benefit, countless studies have worked to develop detonation combustors and integrate these devices into existing systems. This dissertation consists of a series of investigations on two types of detonation combustors: the pulse detonation combustor (PDC) and the rotating detonation combustor (RDC). In the first two investigations, an array of air-breathing PDCs is integrated with an axial power turbine. The system is initially operated with steady and pulsed cold air flow to determine the effect of pulsed flow on turbine performance. Various averaging approaches are employed to calculate turbine efficiency, but only flow-weighted (e.g., mass or work averaging) definitions have physical significance. Pulsed flow turbine efficiency is comparable to steady flow efficiency at high corrected flow rates and low rotor speeds. At these conditions, the pulse duty cycle expands and the variation of the rotor incidence angle is constrained to a favorable range. The system is operated with pulsed detonating flow to determine the effect of frequency, fill fraction, and rotor speed on turbine performance. For some conditions, output power exceeds the maximum attainable value from steady constant pressure combustion due to a significant increase in available power from the detonation products. However, the turbine component efficiency estimated from classical thermodynamic analysis is four times lower than the steady design point efficiency. Analysis of blade angles shows a significant penalty due to the detonation, fill, and purge processes simultaneously imposed on the rotor. The latter six investigations focus on fundamental research of the RDC concept. A specially-tailored RDC data

  15. Influence of Turbulent Fluctuations on Detonation Propagation

    CERN Document Server

    Maxwell, Brian McN; Lau-Chapdelaine, Sebastien S M; Falle, Sam A E G; Sharpe, Gary J; Radulescu, Matei I

    2016-01-01

    The present study addresses the reaction zone structure and burning mechanism of unstable detonations. Experiments investigated mainly two-dimensional methane-oxygen cellular detonations in a thin channel geometry. The sufficiently high temporal resolution permitted to determine the PDF of the shock distribution, a power-law with an exponent of -3, and the burning rate of unreacted pockets from their edges - through surface turbulent flames with a speed approximately 3-7 times larger than the laminar one at the local conditions. Numerical simulations were performed using a novel Large Eddy Simulation method where the reactions due to both auto-ignition and turbulent transport and treated exactly at the sub-grid scale in a reaction-diffusion formulation. The model is an extension of Kerstein & Menon's Linear Eddy Model for Large Eddy Simulation to treat flows with shock waves and rapid gasdynamic transients. The two-dimensional simulations recovered well the amplification of the laminar flame speed owing t...

  16. Multi-Dimensional Double Detonation of Sub-Chandrasekhar Mass White Dwarfs

    CERN Document Server

    Moll, Rainer

    2013-01-01

    Using 2D and 3D simulation, we study the "robustness" of the double detonation scenario for Type Ia supernovae, in which a detonation in the helium shell of a carbon-oxygen white dwarf induces a secondary detonation in the underlying core. We find that a helium detonation cannot easily descend into the core unless it commences (artificially) well above the hottest layer calculated for the helium shell in current presupernova models. Compressional waves induced by the sliding helium detonation, however, robustly generate hot spots which trigger a detonation in the core. Our simulations show that this is true even for non-axisymmetric initial conditions. If the helium is ignited at multiple points, the internal waves can pass through one another or be reflected, but this added complexity does not defeat the generation of the hot spot. The ignition of very low-mass helium shells depends on whether a thermonuclear runaway can simultaneously commence in a sufficiently large region.

  17. A gasdynamic gun driven by gaseous detonation

    Science.gov (United States)

    Li, Jinping; Chen, Hong; Zhang, Shizhong; Zhang, Xiaoyuan; Yu, Hongru

    2016-01-01

    A gasdynamic gun driven by gaseous detonation was developed to address the disadvantages of the insufficient driving capability of high-pressure gas and the constraints of gunpowder. The performance of this gasdynamic gun was investigated through experiments and numerical simulations. Much more powerful launching capability was achieved by this gun relative to a conventional high-pressure gas gun, owing to the use of the chemical energy of the driver gas. To achieve the same launching condition, the initial pressure required for this gun was an order of magnitude lower than that for a gun driven by high-pressure H2. Because of the presence of the detonation, however, a more complex internal ballistic process of this gun was observed. Acceleration of projectiles for this gun was accompanied by a series of impulse loads, in contrast with the smooth acceleration for a conventional one, which indicates that this gun should be used conditionally. The practical feasibility of this gun was verified by experiments. The experiments demonstrated the convenience of taking advantage of the techniques developed for detonation-driven shock tubes and tunnels.

  18. A two dimensional theory for two phase detonation of liquid films.

    Science.gov (United States)

    Rao, C. S. R.; Sichel, M.; Nicholls, J. A.

    1972-01-01

    A theory for the propagation of detonations through tubes coated with a thin fuel film is developed. Vaporization is assumed as the rate limiting process dominating the detonation structure. Inclusion of the boundary layer displacement effect resulted in better agreement between computed and measured propagation speed, pressure ratio, and reaction zone length than was obtained in an earlier theory in which this effect was neglected. New film detonation data is presented covering a wide range of fuel air ratios. A general Chapman-Jouguet condition is formulated for film detonations, and use of the plane of complete film vaporization as the Chapman-Jouguet plane is justified in the case of thin films.

  19. Detonation in supersonic radial outflow

    KAUST Repository

    Kasimov, Aslan R.

    2014-11-07

    We report on the structure and dynamics of gaseous detonation stabilized in a supersonic flow emanating radially from a central source. The steady-state solutions are computed and their range of existence is investigated. Two-dimensional simulations are carried out in order to explore the stability of the steady-state solutions. It is found that both collapsing and expanding two-dimensional cellular detonations exist. The latter can be stabilized by putting several rigid obstacles in the flow downstream of the steady-state sonic locus. The problem of initiation of standing detonation stabilized in the radial flow is also investigated numerically. © 2014 Cambridge University Press.

  20. Double-Front Detonation Waves

    Science.gov (United States)

    Gubin, S. A.; Sumskoi, S. I.; Victorov, S. B.

    According to the theory of detonation, in a detonation wave there is a sound plane, named Chapman-Jouguet (CJ) plane. There are certain stationary parameters for this plane. In this work the possibility of the second CJ plane is shown. This second CJ plane is stationary as well. The physical mechanism of non-equilibrium transition providing the existence of the second CJ plane is presented. There is a non-equilibrium state, when the heat is removed from the reaction zone and the heat capacity decreases sharply. As a result of this non-equilibrium state, the sound velocity increases, and the local supersonic zone with second sonic plane (second CJ plane) appears. So the new mode of detonation wave is predicted. Equations describing this mode of detonation are presented. The exact analytical solution for the second CJ plane parameters is obtained. The example of double-front detonation in high explosive (TNT) is presented. In this double-front structure "nanodiamond-nanographite" phase transition takes place in condensed particles of detonation products.

  1. Investigations on multicycle spray detonations

    Institute of Scientific and Technical Information of China (English)

    LI Mu; YAN Chuanjun; ZHENG Longxi; WANG Zhiwu; QIU Hua

    2007-01-01

    Experimental investigations were carried out on a 50-I.D. Multicycle pulse detonation engine (PDE) model, and liquid fuel (gasoline) was used. The average of pressure peak, as measured by piezoelectricity pressure transducer, increased versus distance to thrust wall before fully-developed detonation came into being. According to the pressure history, the pressure in detonation tube would not rise abruptly until the flame front advanced a certain distance downstream the spark. Just at that moment, two compression waves spreading to opposite direction were formed. One was enforced by combustion and became detonation rapidly. The other was weakened because of obstacles and insufficiency of fuel. Two methods were used to determine the induction length of two-phase detonation wave through the pressure history. Ignition delay time was found to be longer than deflagration-to-detonation transition (DDT) time, and the sum of the two would change little as cycle frequency increased. So they could be the most important factors controlling two-phase PDE frequency. Filling process and blowdown process were also analyzed.

  2. A note on the detonation of TNT

    Directory of Open Access Journals (Sweden)

    M. P. Murgai

    1953-01-01

    Full Text Available Whenever a non-reactive shock passes .through a system which is capable of undergoing an exothermic reaction, the high temperature and pressure in the shock front may start the chemical reaction, and it is possible that the heat evolved, under suitable conditions, map support the wave, and a self sustained stable shock propagate through the system. This shock wave maintained by the heat of the reaction constitutes a stable detonation wave. The equations of conservation of mass, momentum and energy, across the wave give the well known Rankine Huginiot equation. The formulation of an equation of state leaves the conditions behind the pure shook wave undetermined

  3. Diminishing detonator effectiveness through electromagnetic effects

    Energy Technology Data Exchange (ETDEWEB)

    Schill, Jr, Robert A.

    2016-09-20

    An inductively coupled transmission line with distributed electromotive force source and an alternative coupling model based on empirical data and theory were developed to initiate bridge wire melt for a detonator with an open and a short circuit detonator load. In the latter technique, the model was developed to exploit incomplete knowledge of the open circuited detonator using tendencies common to all of the open circuit loads examined. Military, commercial, and improvised detonators were examined and modeled. Nichrome, copper, platinum, and tungsten are the detonator specific bridge wire materials studied. The improvised detonators were made typically made with tungsten wire and copper (.about.40 AWG wire strands) wire.

  4. Detonator assembly for oil well perforating gun

    Energy Technology Data Exchange (ETDEWEB)

    Regalbuto, J.A.

    1981-02-18

    A safe/arm detonator assembly for use with an oil well perforating gun assembly has 2 housing members isolated from well-bore fluid which are rotatable from a safe position wherein a detonator and a booster are held out of alignment, to an armed position wherein the detonator and booster are moved into alignment. The detonator assembly is further arranged to be installed in a well perforating gun assembly such that the gun assembly may be transported with the detonator assembly in the safe position, and rotated to the armed position at the well site without disassembling the gun assembly. A safety pin may protrude from one of the housing members across a cavity between the members to cover and protect the booster from accidental detonation when the detonator assembly is in the safe position. The detonator and booster cavities may be held aligned by a detent ball. 16 claims.

  5. Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates

    Directory of Open Access Journals (Sweden)

    Liang Hong-Erh

    2009-07-01

    Full Text Available Abstract Background Conditional knockout mice are a useful tool to study the function of gene products in a tissue-specific or inducible manner. Classical approaches to generate targeting vectors for conditional alleles are often limited by the availability of suitable restriction sites. Furthermore, plasmid-based targeting vectors can only cover a few kB of DNA which precludes the generation of targeting vectors where the two loxP sites are placed far apart. These limitations have been overcome in the recent past by using homologous recombination of bacterial artificial chromosomes (BACs in Escherichia coli to produce large targeting vector containing two different loxP-flanked selection cassettes so that a single targeting event is sufficient to introduce loxP-sites a great distances into the mouse genome. However, the final targeted allele should be free of selection cassettes and screening for correct removal of selection cassettes can be a laborious task. Therefore, we developed a new strategy to rapidly identify ES cells containing the desired allele. Results Using BAC recombineering we generated a single targeting vector which contained two different selection cassettes that were flanked by loxP-loxP sites or by FRT-FRT/loxP sites so that they could be deleted sequentially by Cre- and FLPe-recombinases, respectively. Transfected ES cells were first selected in the presence of both antibiotics in vitro before correctly targeted clones were identified by Southern blot. After transfection of a Cre recombinase expression plasmid ES cell clones were selected on replicate plates to identify those clones which maintained the FRT-FRT/loxP flanked cassette and lost the loxP-loxP flanked cassette. Using this strategy facilitated the identification of ES cell clones containing the desired allele before blastocyst injection. Conclusion The strategy of ES cell cultures in replicate plates proved to be very efficient in identifying ES cells that had

  6. 广义C-J条件在计算含铝炸药波头参数中的应用%Application of Generalized C-J Condition at Detonation of Aluminized Explosives

    Institute of Scientific and Technical Information of China (English)

    王庭辉; 段祝平; 苏健军; 田清政

    2013-01-01

    含铝炸药的爆轰过程属于典型的非理想爆轰过程,其波头反应区处于多相反应流动状态,因此其波头处爆轰参数的计算一直是一个难点.在假定铝颗粒于波头处不参与化学反应且爆轰产物和铝颗粒压力、速度一致的条件下,应用连续介质模型描述了爆轰产物和铝颗粒两相之间的平衡关系,采用广义C-J条件给出了计算波头处爆压、物质速度和爆热的一组简单完备方程组.由实测得到的爆速,可以求得相应的爆压、物质点速度和波头处释放的热量.对三组不同含铝量(10%,20%,30%)的TNT含铝炸药和HMX含铝炸药的计算结果表明随着爆速的降低,对应的爆压、波头处物质速度和热量都会降低,不同含铝量的同一炸药在同一爆速条件下,含铝量越高对应的爆压值、波头处爆热值越大.同时,对计算假定和采用模型进行了一定的讨论.%The detonation performances of aluminized explosives are the typical non-ideal detonations. Because of the multiphase flowing and reacting at the front of detonation, it was difficult to obtain the detonation parameters by calculation. Assumed that the metal particles have no reaction at the front of detonation,and have the same pressure and velocity with the detonation products, using the continuum model and the general C-J relation,the full equations were obtained. Given the data of experimental detonation velocity,we can obtain the detonation pressure,particles velocity and the released heat at the front of detonation by solving the full equations. The calculations of two explosives with different aluminium content show that with the decrease of detonation velocity, the detonation pressure,mass velocity and explosion heat also deceased. When the explosives with different aluminium contents have the same detonation velocity,the higher the aluminium content,the larger the detonation pressure and the explosion heat. The calculation assumptions

  7. Detonation Jet Engine. Part 1--Thermodynamic Cycle

    Science.gov (United States)

    Bulat, Pavel V.; Volkov, Konstantin N.

    2016-01-01

    We present the most relevant works on jet engine design that utilize thermodynamic cycle of detonative combustion. The efficiency advantages of thermodynamic detonative combustion cycle over Humphrey combustion cycle at constant volume and Brayton combustion cycle at constant pressure were demonstrated. An ideal Ficket-Jacobs detonation cycle, and…

  8. Rotating Detonation Combustion: A Computational Study for Stationary Power Generation

    Science.gov (United States)

    Escobar, Sergio

    The increased availability of gaseous fossil fuels in The US has led to the substantial growth of stationary Gas Turbine (GT) usage for electrical power generation. In fact, from 2013 to 2104, out of the 11 Tera Watts-hour per day produced from fossil fuels, approximately 27% was generated through the combustion of natural gas in stationary GT. The thermodynamic efficiency for simple-cycle GT has increased from 20% to 40% during the last six decades, mainly due to research and development in the fields of combustion science, material science and machine design. However, additional improvements have become more costly and more difficult to obtain as technology is further refined. An alternative to improve GT thermal efficiency is the implementation of a combustion regime leading to pressure-gain; rather than pressure loss across the combustor. One concept being considered for such purpose is Rotating Detonation Combustion (RDC). RDC refers to a combustion regime in which a detonation wave propagates continuously in the azimuthal direction of a cylindrical annular chamber. In RDC, the fuel and oxidizer, injected from separated streams, are mixed near the injection plane and are then consumed by the detonation front traveling inside the annular gap of the combustion chamber. The detonation products then expand in the azimuthal and axial direction away from the detonation front and exit through the combustion chamber outlet. In the present study Computational Fluid Dynamics (CFD) is used to predict the performance of Rotating Detonation Combustion (RDC) at operating conditions relevant to GT applications. As part of this study, a modeling strategy for RDC simulations was developed. The validation of the model was performed using benchmark cases with different levels of complexity. First, 2D simulations of non-reactive shock tube and detonation tubes were performed. The numerical predictions that were obtained using different modeling parameters were compared with

  9. Curved detonation fronts in solid explosives: Collisions and boundary interactions

    Energy Technology Data Exchange (ETDEWEB)

    Bdzil, J.B. [Los Alamos National Lab., NM (United States); Aslam, T.D.; Stewart, D.S. [Univ. of Illinois, Urbana, IL (United States). TAM Dept.

    1995-09-01

    Detonation Shock Dynamics (DSD) can be used to model the effects that shock curvature, {kappa}, has oil detonation speed, D{sub n}({kappa}). At the edges of the explosive, D{sub n}({kappa}) is supplemented with boundary conditions. By direct numerical simulation (DNS). The authors study how the reaction zone interacts with the edge. DSD theory has been integrated with the level-set method of Osher and Sethian and the Los Alamos DNS code Mesa to create a powerful tool for simulating complex explosive containing systems.

  10. The development and testing of pulsed detonation engine ground demonstrators

    Science.gov (United States)

    Panicker, Philip Koshy

    2008-10-01

    The successful implementation of a PDE running on fuel and air mixtures will require fast-acting fuel-air injection and mixing techniques, detonation initiation techniques such as DDT enhancing devices or a pre-detonator, an effective ignition system that can sustain repeated firing at high rates and a fast and capable, closed-loop control system. The control system requires high-speed transducers for real-time monitoring of the PDE and the detection of the detonation wave speed. It is widely accepted that the detonation properties predicted by C-J detonation relations are fairly accurate in comparison to experimental values. The post-detonation flow properties can also be expressed as a function of wave speed or Mach number. Therefore, the PDE control system can use C-J relations to predict the post-detonation flow properties based on measured initial conditions and compare the values with those obtained from using the wave speed. The controller can then vary the initial conditions within the combustor for the subsequent cycle, by modulating the frequency and duty cycle of the valves, to obtain optimum air and fuel flow rates, as well as modulate the energy and timing of the ignition to achieve the required detonation properties. Five different PDE ground demonstrators were designed, built and tested to study a number of the required sub-systems. This work presents a review of all the systems that were tested, along with suggestions for their improvement. The PDE setups, ranged from a compact PDE with a 19 mm (3/4 in.) i.d., to two 25 mm (1 in.) i.d. setups, to a 101 mm (4 in.) i.d. dual-stage PDE setup with a pre-detonator. Propane-oxygen mixtures were used in the smaller PDEs. In the dual-stage PDE, propane-oxygen was used in the pre-detonator, while propane-air mixtures were used in the main combustor. Both rotary valves and solenoid valve injectors were studied. The rotary valves setups were tested at 10 Hz, while the solenoid valves were tested at up to 30 Hz

  11. Detonations in white dwarf dynamical interactions

    CERN Document Server

    Aznar-Siguán, Gabriela; Lorén-Aguilar, Pablo; José, Jordi; Isern, Jordi

    2013-01-01

    In old, dense stellar systems collisions of white dwarfs are a rather frequent phenomenon. Here we present the results of a comprehensive set of Smoothed Particle Hydrodynamics simulations of close encounters of white dwarfs aimed to explore the outcome of the interaction and the nature of the final remnants for different initial conditions. Depending on the initial conditions and the white dwarf masses, three different outcomes are possible. Specifically, the outcome of the interaction can be either a direct or a lateral collision or the interaction can result in the formation of an eccentric binary system. In those cases in which a collision occurs, the infalling material is compressed and heated such that the physical conditions for a detonation may be reached during the most violent phases of the merger. While we find that detonations occur in a significant number of our simulations, in some of them the temperature increase in the shocked region rapidly lifts degeneracy, leading to the quenching of the bu...

  12. The Detonation Mechanism of the Pulsationally-Assisted Gravitationally-Confined Detonation Model of Type Ia Supernovae

    CERN Document Server

    Jordan, G C; Fisher, R T; Townsley, D M; Meakin, C; Weide, K; Reid, L B; Norris, J; Hudson, R; Lamb, D Q

    2012-01-01

    We describe the detonation mechanism comprising the "Pulsationally Assisted" Gravitationally Confined Detonation (GCD) model of Type Ia supernovae (SNe Ia). This model is analogous to the previous GCD model reported in Jordan (2008); however, the chosen initial conditions produce a substantively different detonation mechanism, resulting from a larger energy release during the deflagration phase. The resulting final energy releases and nickel-56 yields conform better to observational values than is the case for the "classical" GCD models. In the present class of models, the ignition of a deflagration phase leads to a rising, burning plume of ash. The ash breaks out of the surface of the white dwarf, flows laterally around the star, and converges on the collision region at the antipodal point from where it broke out. The amount of energy released during the deflagration phase is enough to cause the star to rapidly expand, so that when the ash reaches the antipodal point, the surface density is too low to initia...

  13. Intravenous administration of the conditionally replicative adenovirus Ad5-Δ24RGD induces regression of osteosarcoma lung metastases

    Directory of Open Access Journals (Sweden)

    Gerritsen Winald R

    2008-01-01

    Full Text Available Abstract Metastatic osteosarcoma (OS has a very poor prognosis. New treatments are therefore wanted. The conditionally replicative adenovirus Ad5-Δ24RGD has shown promising anti-tumor effects on local cancers, including OS. The purpose of this study was to determine whether intravenous administration of Ad5-Δ24RGD could suppress growth of human OS lung metastases. Mice bearing SaOs-lm7 OS lung metastases were treated with Ad5-Δ24RGD at weeks 1, 2 and 3 or weeks 5, 6 and 7 after tumor cell injection. Virus treatment at weeks 1–3 did not cause a statistically significant effect on lung weight and total body weight. However, the number of macroscopic lung tumor nodules was reduced from a median of >158 in PBS-treated control mice to 58 in Ad5-Δ24RGD-treated mice (p = 0.15. Moreover, mice treated at weeks 5–7 showed a significantly reduced lung weight (decrease of tumor mass, p 149, p = 0.12 compared to PBS treated control animals. Adenovirus hexon expression was detected in lung tumor nodules at sacrifice three weeks after the last intravenous adenovirus administration, suggesting ongoing viral infection. These findings suggest that systemic administration of Ad5-Δ24RGD might be a promising new treatment strategy for metastatic osteosarcoma.

  14. Detonation re-initiation mechanism following the Mach reflection of a quenched detonation

    CERN Document Server

    Bhattacharjee, Rohit; Maines, Geoffrey; Maley, Logan; Radulescu, Matei Ioan

    2012-01-01

    This experimental study addresses the re-initiation mechanism of detonation waves following the Mach reflection of a shock-flame complex. The detonation diffraction around a cylinder is used to reproducibly generate the shock-flame complex of interest. The experiments are performed in methane-oxygen. We use a novel experimental technique of coupling a two-in-line-spark flash system with a double-frame camera in order to obtain microsecond time resolution permitting accurate schlieren velocimetry. The first series of experiments compares the non-reactive sequence of shock reflections with the reflection over a rough wall under identical conditions. It was found that the hot reaction products generated along the rough wall are entrained by the wall jet into a large vortex structure behind the Mach stem. The second series of experiments performed in more sensitive mixtures addressed the sequence of events leading to the detonation establishment along the Mach and transverse waves. Following ignition and jet entr...

  15. Pulse detonation engines and components thereof

    Science.gov (United States)

    Tangirala, Venkat Eswarlu (Inventor); Rasheed, Adam (Inventor); Vandervort, Christian Lee (Inventor); Dean, Anthony John (Inventor)

    2009-01-01

    A pulse detonation engine comprises a primary air inlet; a primary air plenum located in fluid communication with the primary air inlet; a secondary air inlet; a secondary air plenum located in fluid communication with the secondary air inlet, wherein the secondary air plenum is substantially isolated from the primary air plenum; a pulse detonation combustor comprising a pulse detonation chamber, wherein the pulse detonation chamber is located downstream of and in fluid communication with the primary air plenum; a coaxial liner surrounding the pulse detonation combustor defining a cooling plenum, wherein the cooling plenum is in fluid communication with the secondary air plenum; an axial turbine assembly located downstream of and in fluid communication with the pulse detonation combustor and the cooling plenum; and a housing encasing the primary air plenum, the secondary air plenum, the pulse detonation combustor, the coaxial liner, and the axial turbine assembly.

  16. Environmentally Benign Stab Detonators

    Energy Technology Data Exchange (ETDEWEB)

    Gash, A E

    2006-07-07

    The coupling of energetic metallic multilayers (a.k.a. flash metal) with energetic sol-gel synthesis and processing is an entirely new approach to forming energetic devices for several DoD and DOE needs. They are also practical and commercially viable manufacturing techniques. Improved occupational safety and health, performance, reliability, reproducibility, and environmentally acceptable processing can be achieved using these methodologies and materials. The development and fielding of this technology will enhance mission readiness and reduce the costs, environmental risks and the necessity of resolving environmental concerns related to maintaining military readiness while simultaneously enhancing safety and health. Without sacrificing current performance, we will formulate new impact initiated device (IID) compositions to replace materials from the current composition that pose significant environmental, health, and safety problems associated with functions such as synthesis, material receipt, storage, handling, processing into the composition, reaction products from testing, and safe disposal. To do this, we will advance the use of nanocomposite preparation via the use of multilayer flash metal and sol-gel technologies and apply it to new small IIDs. This work will also serve to demonstrate that these technologies and resultant materials are relevant and practical to a variety of energetic needs of DoD and DOE. The goal will be to produce an IID whose composition is acceptable by OSHA, EPA, the Clean Air Act, Clean Water Act, Resource Recovery Act, etc. standards, without sacrificing current performance. The development of environmentally benign stab detonators and igniters will result in the removal of hazardous and toxic components associated with their manufacturing, handling, and use. This will lead to improved worker safety during manufacturing as well as reduced exposure of Service personnel during their storage and or use in operations. The

  17. High temperature oxidation studies of detonation-gun-sprayed Cr{sub 3}C{sub 2}-NiCr coating on Fe- and Ni-based superalloys in air under cyclic condition at 900 deg. C

    Energy Technology Data Exchange (ETDEWEB)

    Kamal, Subhash [Department of Metallurgical and Materials Engineering, Indian Institute of Technology Roorkee, IIT Roorkee Campus, Roorkee 247667, Uttaranchal (India); Jayaganthan, R. [Department of Metallurgical and Materials Engineering, Indian Institute of Technology Roorkee, IIT Roorkee Campus, Roorkee 247667, Uttaranchal (India)], E-mail: rjayafmt@iitr.ernet.in; Prakash, S. [Department of Metallurgical and Materials Engineering, Indian Institute of Technology Roorkee, IIT Roorkee Campus, Roorkee 247667, Uttaranchal (India)

    2009-03-20

    The cyclic oxidation behavior of detonation-gun-sprayed Cr{sub 3}C{sub 2}-NiCr coating on three different superalloys namely Superni 75, Superni 718 and Superfer 800H at 900 deg. C for 100 cycles in air under cyclic heating and cooling conditions has been investigated in the present work. The kinetics of oxidation of coated and bare superalloys was analysed, using thermogravimetric technique. It was observed that all the coated and bare superalloys obey a parabolic rate law of oxidation. X-ray diffraction, FE-SEM/EDAX and X-ray mapping techniques were used to analyse the oxidation products of coated and bare superalloys. The results on the Cr{sub 3}C{sub 2}-NiCr-coated superalloys showed better oxidation resistance due to the formation of a compact and adhesive thin Cr{sub 2}O{sub 3} scale on the surface of the coating during oxidation. The scale remained intact and adherent to the partially oxidised coating during cyclic oxidation due to its good compatibility and similar thermal expansion coefficient between Cr{sub 3}C{sub 2}-NiCr coating and the superalloy substrates. In all the coated superalloys, the chromium, iron, silicon and titanium were oxidised in the inter-splat region, whereas splats which consisted mainly of Ni remained unoxidised. The parabolic rate constants of Cr{sub 3}C{sub 2}-NiCr-coated alloys were lower than that of the bare superalloys as observed in the present work.

  18. Breakthrough or one-hit wonder? Three attempts to replicate single-exposure musical conditioning effects on choice behavior (Gorn, 1982).

    NARCIS (Netherlands)

    Vermeulen, I.E.; Batenburg, A.E.; Beukeboom, C.J.; Smits, T.

    2014-01-01

    Three studies replicated a classroom experiment on single-exposure musical conditioning of consumer choice (Gorn, 1982), testing whether simultaneous exposure to liked (vs. disliked) music and a pen image induced preferences for the shown (vs. a different) pen. Experiments 1 and 2 employed the origi

  19. E-cigarettes emit very high formaldehyde levels only in conditions that are aversive to users: A replication study under verified realistic use conditions.

    Science.gov (United States)

    Farsalinos, Konstantinos E; Voudris, Vassilis; Spyrou, Alketa; Poulas, Konstantinos

    2017-08-31

    In 2015, a study identified 5-15-fold higher levels of formaldehyde emissions from an old-generation e-cigarette tested at 5.0 V compared to tobacco cigarettes. We set to replicate this study using the same e-cigarette equipment and e-liquid, while checking for the generation of dry puffs. Experienced e-cigarette users (n = 26) took 4 s puffs at different voltage settings and were asked to report the generation of dry puffs. Formaldehyde emissions were measured at both realistic and dry puff conditions. Dry puffs were detected at ≤4.2 V by 88% of participants; thus, 4.0 V was defined as the upper limit of realistic use. Levels ranged from 3.4 (SE = 2.2) μg/10 puffs at 3.3 V to 718.2 (SE = 58.2) μg/10 puffs at 5.0 V. The levels detected at 4.0 V were 19.8 (SE = 5.6) μg/10 puffs. At 4.0 V, the daily exposure to formaldehyde from consuming 3 g of liquid with the device tested would be 32% lower compared to smoking 20 tobacco cigarettes. The high levels of formaldehyde emissions that were reported in a previous study were caused by unrealistic use conditions that create the unpleasant taste of dry puffs to e-cigarette users and are thus avoided. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Direct Initiation Through Detonation Branching in a Pulsed Detonation Engine

    Science.gov (United States)

    2008-03-01

    Detonation Engine The core of the PDE used in this research is a General Motors (GM) Quad 4 engine head with dual overhead camshafts . The head...manifold injection lines labeled The conventional poppet style valves are mechanically actuated by their respective camshafts which are in turn driven by...the angular position of the camshaft which is then used by the control computer to determine valve position and subsequent firing times. Depending

  1. Experimental Investigation on Performance of Pulse Detonation Rocket Engine Model

    Institute of Scientific and Technical Information of China (English)

    LI Qiang; FAN Wei; YAN Chuan-jun; HU Cheng-qi; YE Bin

    2007-01-01

    The PDRE test model used in these experiments utilized kerosene as the fuel, oxygen as oxidizer, and nitrogen as purge gas. The solenoid valves were employed to control intermittent supplies of kerosene, oxygen and purge gas. PDRE test model was 50 mm in inner diameter by 1.2 m long. The DDT (defiagration to detonation transition) enhancement device Shchelkin spiral was used in the test model.The effects of detonation frequency on its time-averaged thrust and specific impulse were experimentally investigated. The obtained results showes that the time-averaged thrust of PDRE test model was approximately proportional to the detonation frequency. For the detonation frequency 20 Hz, the time-averaged thrust was around 107 N, and the specific impulse was around 125 s. The nozzle experiments were conducted using PDRE test model with three traditional nozzles. The experimental results obtained demonstrated that all of those nozzles could augment the thrust and specific impulse. Among those three nozzles, the convergent nozzle had the largest increased augmentation, which was approximately 18%, under the specific condition of the experiment.

  2. A thermochemically derived global reaction mechanism for detonation application

    Science.gov (United States)

    Zhu, Y.; Yang, J.; Sun, M.

    2012-07-01

    A 4-species 4-step global reaction mechanism for detonation calculations is derived from detailed chemistry through thermochemical approach. Reaction species involved in the mechanism and their corresponding molecular weight and enthalpy data are derived from the real equilibrium properties. By substituting these global species into the results of constant volume explosion and examining the evolution process of these global species under varied conditions, reaction paths and corresponding rates are summarized and formulated. The proposed mechanism is first validated to the original chemistry through calculations of the CJ detonation wave, adiabatic constant volume explosion, and the steady reaction structure after a strong shock wave. Good agreement in both reaction scales and averaged thermodynamic properties has been achieved. Two sets of reaction rates based on different detailed chemistry are then examined and applied for numerical simulations of two-dimensional cellular detonations. Preliminary results and a brief comparison between the two mechanisms are presented. The proposed global mechanism is found to be economic in computation and also competent in description of the overall characteristics of detonation wave. Though only stoichiometric acetylene-oxygen mixture is investigated in this study, the method to derive such a global reaction mechanism possesses a certain generality for premixed reactions of most lean hydrocarbon mixtures.

  3. A Semi-analytic Criterion for the Spontaneous Initiation of Carbon Detonations in White Dwarfs

    Science.gov (United States)

    Garg, Uma; Chang, Philip

    2017-02-01

    Despite over 40 years of active research, the nature of the white dwarf progenitors of SNe Ia remains unclear. However, in the last decade, various progenitor scenarios have highlighted the need for detonations to be the primary mechanism by which these white dwarfs are consumed, but it is unclear how these detonations are triggered. In this paper we study how detonations are spontaneously initiated due to temperature inhomogeneities, e.g., hotspots, in burning nuclear fuel in a simplified physical scenario. Following the earlier work by Zel’Dovich, we describe the physics of detonation initiation in terms of the comparison between the spontaneous wave speed and the Chapman–Jouguet speed. We develop an analytic expression for the spontaneous wave speed and utilize it to determine a semi-analytic criterion for the minimum size of a hotspot with a linear temperature gradient between a peak and base temperature for which detonations in burning carbon–oxygen material can occur. Our results suggest that spontaneous detonations may easily form under a diverse range of conditions, likely allowing a number of progenitor scenarios to initiate detonations that burn up the star.

  4. Pulse Detonation Rocket MHD Power Experiment

    Science.gov (United States)

    Litchford, Ron J.; Cook, Stephen (Technical Monitor)

    2002-01-01

    A pulse detonation research engine (MSFC (Marshall Space Flight Center) Model PDRE (Pulse Detonation Rocket Engine) G-2) has been developed for the purpose of examining integrated propulsion and magnetohydrodynamic power generation applications. The engine is based on a rectangular cross-section tube coupled to a converging-diverging nozzle, which is in turn attached to a segmented Faraday channel. As part of the shakedown testing activity, the pressure wave was interrogated along the length of the engine while running on hydrogen/oxygen propellants. Rapid transition to detonation wave propagation was insured through the use of a short Schelkin spiral near the head of the engine. The measured detonation wave velocities were in excess of 2500 m/s in agreement with the theoretical C-J velocity. The engine was first tested in a straight tube configuration without a nozzle, and the time resolved thrust was measured simultaneously with the head-end pressure. Similar measurements were made with the converging-diverging nozzle attached. The time correlation of the thrust and head-end pressure data was found to be excellent. The major purpose of the converging-diverging nozzle was to configure the engine for driving an MHD generator for the direct production of electrical power. Additional tests were therefore necessary in which seed (cesium-hydroxide dissolved in methanol) was directly injected into the engine as a spray. The exhaust plume was then interrogated with a microwave interferometer in an attempt to characterize the plasma conditions, and emission spectroscopy measurements were also acquired. Data reduction efforts indicate that the plasma exhaust is very highly ionized, although there is some uncertainty at this time as to the relative abundance of negative OH ions. The emission spectroscopy data provided some indication of the species in the exhaust as well as a measurement of temperature. A 24-electrode-pair segmented Faraday channel and 0.6 Tesla permanent

  5. Pulse Detonation Rocket MHD Power Experiment

    Science.gov (United States)

    Litchford, Ron J.; Cook, Stephen (Technical Monitor)

    2002-01-01

    A pulse detonation research engine (MSFC (Marshall Space Flight Center) Model PDRE (Pulse Detonation Rocket Engine) G-2) has been developed for the purpose of examining integrated propulsion and magnetohydrodynamic power generation applications. The engine is based on a rectangular cross-section tube coupled to a converging-diverging nozzle, which is in turn attached to a segmented Faraday channel. As part of the shakedown testing activity, the pressure wave was interrogated along the length of the engine while running on hydrogen/oxygen propellants. Rapid transition to detonation wave propagation was insured through the use of a short Schelkin spiral near the head of the engine. The measured detonation wave velocities were in excess of 2500 m/s in agreement with the theoretical C-J velocity. The engine was first tested in a straight tube configuration without a nozzle, and the time resolved thrust was measured simultaneously with the head-end pressure. Similar measurements were made with the converging-diverging nozzle attached. The time correlation of the thrust and head-end pressure data was found to be excellent. The major purpose of the converging-diverging nozzle was to configure the engine for driving an MHD generator for the direct production of electrical power. Additional tests were therefore necessary in which seed (cesium-hydroxide dissolved in methanol) was directly injected into the engine as a spray. The exhaust plume was then interrogated with a microwave interferometer in an attempt to characterize the plasma conditions, and emission spectroscopy measurements were also acquired. Data reduction efforts indicate that the plasma exhaust is very highly ionized, although there is some uncertainty at this time as to the relative abundance of negative OH ions. The emission spectroscopy data provided some indication of the species in the exhaust as well as a measurement of temperature. A 24-electrode-pair segmented Faraday channel and 0.6 Tesla permanent

  6. Radioactive Fallout from Terrorist Nuclear Detonations

    Energy Technology Data Exchange (ETDEWEB)

    Marrs, R E

    2007-05-03

    Responding correctly during the first hour after a terrorist nuclear detonation is the key to reducing casualties from a low-yield surface burst, and a correct response requires an understanding of the rapidly changing dose rate from fallout. This report provides an empirical formula for dose rate as a function of time and location that can guide the response to an unexpected nuclear detonation. At least one post-detonation radiation measurement is required if the yield and other characteristics of the detonation are unknown.

  7. Laser diode initiated detonators for space applications

    Science.gov (United States)

    Ewick, David W.; Graham, J. A.; Hawley, J. D.

    1993-01-01

    Ensign Bickford Aerospace Company (EBAC) has over ten years of experience in the design and development of laser ordnance systems. Recent efforts have focused on the development of laser diode ordnance systems for space applications. Because the laser initiated detonators contain only insensitive secondary explosives, a high degree of system safety is achieved. Typical performance characteristics of a laser diode initiated detonator are described in this paper, including all-fire level, function time, and output. A finite difference model used at EBAC to predict detonator performance, is described and calculated results are compared to experimental data. Finally, the use of statistically designed experiments to evaluate performance of laser initiated detonators is discussed.

  8. Deflagrations and Detonations in Thermonuclear Supernovae

    CERN Document Server

    Gamezo, V N; Oran, E S; Gamezo, Vadim N.; Khokhlov, Alexei M.; Oran, Elaine S.

    2004-01-01

    We study a type Ia supernova explosion using three-dimensional numerical simulations based on reactive fluid dynamics. We consider a delayed-detonation model that assumes a deflagration-to-detonation transition. In contrast to the pure deflagration model, the delayed-detonation model releases enough energy to account for a healthy explosion, and does not leave carbon, oxygen, and intermediate-mass elements in central parts of a white dwarf. This removes the key disagreement between simulations and observations, and makes a delayed detonation the mostly likely mechanism for type Ia supernovae.

  9. Minichromosome replication in vitro: inhibition of re-replication by replicatively assembled nucleosomes.

    Science.gov (United States)

    Krude, T; Knippers, R

    1994-08-19

    Single-stranded circular DNA, containing the SV40 origin sequence, was used as a template for complementary DNA strand synthesis in cytosolic extracts from HeLa cells. In the presence of the replication-dependent chromatin assembly factor CAF-1, defined numbers of nucleosomes were assembled during complementary DNA strand synthesis. These minichromosomes were then induced to semiconservatively replicate by the addition of the SV40 initiator protein T antigen (re-replication). The results indicate that re-replication of minichromosomes appears to be inhibited by two independent mechanisms. One acts at the initiation of minichromosome re-replication, and the other affects replicative chain elongation. To directly demonstrate the inhibitory effect of replicatively assembled nucleosomes, two types of minichromosomes were prepared: (i) post-replicative minichromosomes were assembled in a reaction coupled to replication as above; (ii) pre-replicative minichromosomes were assembled independently of replication on double-stranded DNA. Both types of minichromosomes were used as templates for DNA replication under identical conditions. Replicative fork movement was found to be impeded only on post-replicative minichromosome templates. In contrast, pre-replicative minichromosomes allowed one unconstrained replication cycle, but re-replication was inhibited due to a block in fork movement. Thus, replicatively assembled chromatin may have a profound influence on the re-replication of DNA.

  10. Conditioned blocking and schizophrenia: a replication and study of the role of symptoms, age, onset-age of psychosis and illness-duration

    OpenAIRE

    Bender,; Müller; Oades,; Sartory,

    2001-01-01

    Introduction: Measures of selective attention processing like latent inhibition (LI) and conditioned blocking (CB) are disturbed in some patients with schizophrenia. (LI is the delay in learning about the associations of a stimulus that has been associated with no event [vs. de novo learning]; CB is the delay in learning the associations of a stimulus-component when the other component has already started to acquire these associations.) We proposed, - a) to replicate the reported decre...

  11. VELOCITY OF DETONATION OF LOW DENSITY

    Directory of Open Access Journals (Sweden)

    Vinko Škrlec

    2012-12-01

    Full Text Available Blasting operations in built-up areas, at short distances from structures, impose new requirements on blasting techniques and properties of explosives in order to mitigate seismic effect of blasting. Explosives for civil uses are mixtures of different chemical composition of explosive and/or non-explosive substances. Chemical and physical properties, along with means of initiation, environment and the terms of application define detonation and blasting parameters of a particular type of the explosive for civil uses. Velocity of detonation is one of the most important measurable characteristics of detonation parameters which indirectly provide information about the liberated energy, quality of explosives and applicability for certain purposes. The level of shock effect of detonated charge on the rock, and therefore the level of seismic effect in the area, depends on the velocity of detonation. Since the velocity of detonation is proportional to the density of an explosive, the described research is carried out in order to determine the borderline density of the mixture of an emulsion explosive with expanded polystyrene while achieving stable detonation, and to determine the dependency between the velocity of detonation and the density of mixture (the paper is published in Croatian.

  12. Exploratory study on new pulse detonation engines

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The worldwide progress in studies on pulse detonation engines (PDE) is briefly reviewed and some results of our exploratory study on PDE are presented. Analysis of thermodynamic cycle is made and the specific impulse formula is improved. A proof-of-principle experiment of a two-phase PDE is successfully carried out, using poor-detonable liquid C8H16/air mixture with a low-energy system (total spark energy of 50 mJ) and a newly developed one-step detonation initiation method. The measured detonation wave pressure ratio is very close to that of C-J detonation. The effects of length, diameter and detonation frequency on PDE performance are experimentally investigated. For liquid hydrocarbon fuel/air mixture, the PDE operation is successfully realized with an engine length of 1000 mm and detonation frequency up to 36 Hz, which has made an important step toward practical PDE. The developed code can be used for simulating PDE operation processes including deflagration to detonation transition (DDT) phenomenon. The numerical results are in good agreement with the experimental ones.

  13. 14 CFR 33.47 - Detonation test.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Detonation test. 33.47 Section 33.47 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Block Tests; Reciprocating Aircraft Engines § 33.47 Detonation test. Each...

  14. Pulse detonation assembly and hybrid engine

    Science.gov (United States)

    Rasheed, Adam (Inventor); Dean, Anthony John (Inventor); Vandervort, Christian Lee (Inventor)

    2010-01-01

    A pulse detonation (PD) assembly includes a number of PD chambers adapted to expel respective detonation product streams and a number of barriers disposed between respective pairs of PD chambers. The barriers define, at least in part, a number of sectors that contain at least one PD chamber. A hybrid engine includes a number of PD chambers and barriers. The hybrid engine further includes a turbine assembly having at least one turbine stage, being in flow communication with the PD chambers and being configured to be at least partially driven by the detonation product streams. A segmented hybrid engine includes a number of PD chambers and segments configured to receive and direct the detonation product streams from respective PD chambers. The segmented hybrid engine further includes a turbine assembly configured to be at least partially driven by the detonation product streams.

  15. Molecular-dynamics study of detonation. I. A comparison with hydrodynamic predictions

    Science.gov (United States)

    Rice, Betsy M.; Mattson, William; Grosh, John; Trevino, S. F.

    1996-01-01

    We have compared the predictions of hydrodynamic theory for the properties of an unsupported detonation with the results of a molecular dynamics simulation of such a phenomenon. The model of an energetic crystal consists of heteronuclear diatomic molecules that require energy to break the molecular bonds (at ambient pressure); substantial energy is then released upon association of the products to form homonuclear diatomic molecules. The equation of state used in the hydrodynamic theory is determined from two-dimensional molecular dynamics simulations of this model at various equilibrium conditions corresponding to volumes and temperatures appropriate to the detonation. The Chapman-Jouguet conditions of detonation were thus determined. The properties of the detonation were subsequently measured directly from two-dimensional molecular dynamics simulations of the crystal model subjected to shock initiation. The agreement between the hydrodynamic predictions and the measured properties is good. Deviations from exact agreement are attributed to slight differences in material composition in the detonation simulation compared to that of the equation of state calculations. The critical property for sustained detonation using this model appears to be the attainment of the Chapman-Jouguet density.

  16. A Kinetic Approach to Propagation and Stability of Detonation Waves

    Science.gov (United States)

    Monaco, R.; Bianchi, M. Pandolfi; Soares, A. J.

    2008-12-01

    The problem of the steady propagation and linear stability of a detonation wave is formulated in the kinetic frame for a quaternary gas mixture in which a reversible bimolecular reaction takes place. The reactive Euler equations and related Rankine-Hugoniot conditions are deduced from the mesoscopic description of the process. The steady propagation problem is solved for a Zeldovich, von Neuman and Doering (ZND) wave, providing the detonation profiles and the wave thickness for different overdrive degrees. The one-dimensional stability of such detonation wave is then studied in terms of an initial value problem coupled with an acoustic radiation condition at the equilibrium final state. The stability equations and their initial data are deduced from the linearized reactive Euler equations and related Rankine-Hugoniot conditions through a normal mode analysis referred to the complex disturbances of the steady state variables. Some numerical simulations for an elementary reaction of the hydrogen-oxygen chain are proposed in order to describe the time and space evolution of the instabilities induced by the shock front perturbation.

  17. Impact sensitivity and the maximum heat of detonation.

    Science.gov (United States)

    Politzer, Peter; Murray, Jane S

    2015-10-01

    We demonstrate that a large heat of detonation is undesirable from the standpoint of the impact sensitivity of an explosive and also unnecessary from the standpoints of its detonation velocity and detonation pressure. High values of the latter properties can be achieved even with a moderate heat of detonation, and this in turn enhances the likelihood of relatively low sensitivity.

  18. Study of detonation wave contours in EFP warhead

    Directory of Open Access Journals (Sweden)

    Xu-dong Zu

    2016-04-01

    The results show that the planar detonation wave do better than the conical detonation and the spherical detonation wave in increasing the length–diameter ratio of explosively-formed projectiles (EFP and keep the nose of EFP integrated. The detonation wave can increase the length–diameter ratio of EFP when the wave shaper has the suitable thickness.

  19. Planktonic replication is essential for biofilm formation by Legionella pneumophila in a complex medium under static and dynamic flow conditions

    DEFF Research Database (Denmark)

    Mampel, J.; Spirig, T.; Weber, S.S.

    2006-01-01

    within biofilms in the absence of protozoa. In this study, we analyzed surface adherence of and biofilm formation by L. pneumophila in a rich medium that supported axenic replication. Biofilm formation by the virulent L. pneumophila strain JR32 and by clinical and environmental isolates was analyzed...... formed biofilms in the inverse system if the medium was exchanged twice a day. However, after addition of Acanthamoeba castellanii, the bacteria proliferated and adhered to surfaces. Sessile (surface-attached) and planktonic (free-swimming) L. pneumophila expressed beta-galactosidase activity to similar...... extents, and therefore, the observed lack of proliferation of surface-attached bacteria was not due to impaired protein synthesis or metabolic activity. Cocultivation of green fluorescent protein (GFP)- and DsRed-labeled L. pneumophila led to randomly interspersed cells on the substratum and in aggregates...

  20. Detonation initiation developing from the Richtmyer-Meshkov instability

    Institute of Scientific and Technical Information of China (English)

    H.H.Teng; Z.L.Jiang; Z.M.Hu

    2007-01-01

    Detonation initiation resulting from theRichtmyer-Meshkov instability is investigated numericallyin the configuration of the shock/spark-induced-deflagrationinteraction in a combustive gas mixture. Two-dimensionalmulti-species Navier-Stokes equations implemented with thedetailed chemical reaction model are solved with thedispersion-controlled dissipative scheme. Numerical resultsshow that the spark can create a blast wave and ignite defla-grations. Then, the deflagration waves are enhanced due tothe Richtmyer-Meshkov instability, which provides detona-tion initiations with local environment conditions. Byexamining the deflagration fronts, two kinds of the initiationmechanisms are identified. One is referred to as the deflagra-tion front acceleration with the help of the weak shock wave,occurring on the convex surfaces, and the other is the hotspot explosion deriving from the deflagration front focusing,occurring on the concave surfaces.

  1. Chlamydia psittaci reference genes for normalisation of expression data differ depending on the culture conditions and selected time points during the chlamydial replication cycle

    Directory of Open Access Journals (Sweden)

    Van Lent Sarah

    2016-12-01

    Full Text Available Introduction: Chlamydia psittaci is a gram-negative obligate intracellular pathogen of birds. Poultry infections lead to economic losses and can be transmitted to humans. No vaccine is available and the bacterium-host cell interaction is not completely understood. Replicating bacteria cause pneumonia, but C. psittaci can also be non-replicating and persistent inside the cytoplasm of avian cells. RT-qPCR provides insight into the molecular pathogenesis of both active replicating and persistent Chlamydia psittaci in birds, but requires identification of stably expressed reference genes to avoid biases. Material and Methods: We investigated the expression stability of 10 C. psittaci candidate reference genes for gene expression analysis during normal growth and penicillin-induced persistence. C. psittaci Cal10 was cultured in HeLa229 and RNA was extracted. The expression level of each candidate was examined by RT-qPCR and Cq values were analysed using geNorm. Results: The genes tyrS, gidA, radA, and 16S rRNA ranked among the most stably expressed. The final selected reference genes differed according to the bacterial growth status (normal growth versus persistent status, and the time points selected during the duration of the normal chlamydial developmental cycle. Conclusion: The study data show the importance of systematic validation of reference genes to confirm their stability within the strains and under the conditions selected.

  2. CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus

    Directory of Open Access Journals (Sweden)

    Young Lawrence S

    2010-03-01

    Full Text Available Abstract Background CD40 and its ligand (CD40L play a critical role in co-ordinating immune responses. CD40 is also expressed in lymphoid malignancies and a number of carcinomas. In carcinoma cells the physiological outcome of CD40 ligation depends on the level of receptor engagement with low levels promoting cell survival and high levels inducing cell death. The most profound induction of cell death in carcinoma cells is induced by membrane-bound rather than recombinant soluble CD40L, but like other TNF family ligands, it is cleaved from the membrane by matrix metalloproteinases. Results We have generated a replication-deficient adenovirus expressing a mutant CD40L that is resistant to metalloproteinase cleavage such that ligand expression is retained at the cell membrane. Here we show that the mutated, cleavage-resistant form of CD40L is a more potent inducer of apoptosis than wild-type ligand in CD40-positive carcinoma cell lines. Since transgene expression via replication-deficient adenovirus vectors in vivo is low, we have also engineered a conditionally replicating E1A-CR2 deleted adenovirus to express mutant CD40L, resulting in significant amplification of ligand expression and consequent enhancement of its therapeutic effect. Conclusions Combined with numerous studies demonstrating its immunotherapeutic potential, these data provide a strong rationale for the exploitation of the CD40-CD40L pathway for the treatment of solid tumours.

  3. Experimental investigation on noise radiation characteristics of pulse detonation engine–driven ejector

    Directory of Open Access Journals (Sweden)

    Xi-qiao Huang

    2015-06-01

    Full Text Available The noise radiation characteristics of multi-cycle pulse detonation engine with and without ejector were investigated under different operating frequencies utilizing gasoline as fuel and air as oxidizer. The straight cylindrical ejector with convergent inlet geometry was coaxially installed at different axial locations relative to the exit of the detonation tube. In all the experiments, the equivalence ratios of gasoline–air mixture and the fill fraction were 1.2 and 1.0, respectively. The experimental results implied that the addition of ejector could drastically change the far-field acoustic performance of pulse detonation engine exit and the peak sound pressure level of noise radiation was a strong function of the ejector axial position. But the peak sound pressure level was not sensitive to the operating frequencies which varied from 10 to 25 Hz. The pulse sound pressure level, however, increased with the increase in operating frequencies. The far-field jet-noise measurements of the pulse detonation engine-ejector system also showed that ejector could decrease the peak sound pressure level of pulse detonation engine. The maximum reduction was approximately 8.5 dB. For the current pulse detonation engine test conditions, an optimum ejector position was found to be a downstream axial placement of x/DPDE  = 0.5.

  4. Use of noise attenuation modeling in managing missile motor detonation activities.

    Science.gov (United States)

    McFarland, Michael J; Watkins, Jeffrey W; Kordich, Micheal M; Pollet, Dean A; Palmer, Glenn R

    2004-03-01

    The Sound Intensity Prediction System (SIPS) and Blast Operation Overpressure Model (BOOM) are semiempirical sound models that are employed by the Utah Test and Training Range (UTTR) to predict whether noise levels from the detonation of large missile motors will exceed regulatory thresholds. Field validation of SIPS confirmed that the model was effective in limiting the number of detonations of large missile motors that could potentially result in a regulatory noise exceedance. Although the SIPS accurately predicted the impact of weather on detonation noise propagation, regulators have required that the more conservative BOOM model be employed in conjunction with SIPS in evaluating peak noise levels in populated areas. By simultaneously considering the output of both models, in 2001, UTTR detonated 104 missile motors having net explosive weights (NEW) that ranged between 14,960 and 38,938 lb without a recorded public noise complaint. Based on the encouraging results, the U.S. Department of Defense is considering expanding the application of these noise models to support the detonation of missile motors having a NEW of 81,000 lb. Recent modeling results suggest that, under appropriate weather conditions, missile motors containing up to 96,000 lb NEW can be detonated at the UTTR without exceeding the regulatory noise limit of 134 decibels (dB).

  5. Spontaneous Initiation of Detonations in White Dwarf Environments: Determination of Critical Sizes

    CERN Document Server

    Seitenzahl, Ivo R; Townsley, Dean M; Lamb, Don Q; Truran, James W

    2009-01-01

    Some explosion models for Type Ia supernovae (SN Ia), such as the gravitationally confined detonation (GCD) or the double detonation sub-Chandrasekhar (DDSC) models, rely on the spontaneous initiation of a detonation in the degenerate C/O material of a white dwarf. The length scales pertinent to the initiation of the detonation are notoriously unresolved in multi-dimensional stellar simulations, prompting the use of results of 1D simulations at higher resolution, such as the ones performed for this work, as guidelines for deciding whether or not conditions reached in the higher dimensional full star simulations successfully would lead to the onset of a detonation. Spontaneous initiation relies on the existence of a suitable gradient in self-ignition (induction) times of the fuel, which we set up with a spatially localized non-uniformity of temperature -- a hot spot. We determine the critical (smallest) sizes of such hot spots that still marginally result in a detonation in white dwarf matter by integrating th...

  6. Spontaneous Initiation of Detonations in White Dwarf Environments: Determination of Critical Sizes

    Science.gov (United States)

    Seitenzahl, Ivo R.; Meakin, Casey A.; Townsley, Dean M.; Lamb, Don Q.; Truran, James W.

    2009-05-01

    Some explosion models for Type Ia supernovae (SNe Ia), such as the gravitationally confined detonation (GCD) or the double detonation sub-Chandrasekhar (DDSC) models, rely on the spontaneous initiation of a detonation in the degenerate 12C}/16O} material of a white dwarf (WD). The length scales pertinent to the initiation of the detonation are notoriously unresolved in multidimensional stellar simulations, prompting the use of results of one-dimensional simulations at higher resolution, such as those performed for this work, as guidelines for deciding whether or not conditions reached in the higher dimensional full star simulations successfully would lead to the onset of a detonation. Spontaneous initiation relies on the existence of a suitable gradient in self-ignition (induction) times of the fuel, which we set up with a spatially localized nonuniformity of temperature—a hot spot. We determine the critical (smallest) sizes of such hot spots that still marginally result in a detonation in WD matter by integrating the reactive Euler equations with the hydrodynamics code FLASH. We quantify the dependences of the critical sizes of such hot spots on composition, background temperature, peak temperature, geometry, and functional form of the temperature disturbance, many of which were hitherto largely unexplored in the literature. We discuss the implications of our results in the context of modeling of SNe Ia.

  7. A Three-Dimensional Picture of the Delayed-Detonation Model of Type Ia Supernovae

    CERN Document Server

    Bravo, Eduardo

    2007-01-01

    Deflagration models poorly explain the observed diversity of SNIa. Current multidimensional simulations of SNIa predict a significant amount of, so far unobserved, carbon and oxygen moving at low velocities. It has been proposed that these drawbacks can be resolved if there is a sudden jump to a detonation (delayed detonation), but this kind of models has been explored mainly in one dimension. Here we present new three-dimensional delayed detonation models in which the deflagraton-to-detonation transition (DDT) takes place in conditions like those favored by one-dimensional models. We have used a SPH code adapted to SNIa with algorithms devised to handle subsonic as well as supersonic combustion fronts. The starting point was a C-O white dwarf of 1.38 solar masses. When the average density on the flame surface reached 2-3x10^7 g/cm^3 a detonation was launched. The detonation wave processed more than 0.3 solar masses of carbon and oxygen, emptying the central regions of the ejecta of unburned fuel and raising ...

  8. Development of a Gas-Fed Pulse Detonation Research Engine

    Science.gov (United States)

    Litchford, Ron J.; Hutt, John (Technical Monitor)

    2001-01-01

    In response to the growing need for empirical data on pulse detonation engine performance and operation, NASA Marshall Space Flight Center has developed and placed into operation a low-cost gas-fed pulse detonation research engine. The guiding design strategy was to achieve a simple and flexible research apparatus, which was inexpensive to build and operate. As such, the engine was designed to operate as a heat sink device, and testing was limited to burst-mode operation with run durations of a few seconds. Wherever possible, maximum use was made of standard off-the-shelf industrial or automotive components. The 5-cm diameter primary tube is about 90-cm long and has been outfitted with a multitude of sensor and optical ports. The primary tube is fed by a coaxial injector through an initiator tube, which is inserted directly into the injector head face. Four auxiliary coaxial injectors are also integrated into the injector head assembly. All propellant flow is controlled with industrial solenoid valves. An automotive electronic ignition system was adapted for use, and spark plugs are mounted in both tubes so that a variety of ignition schemes can be examined. A microprocessor-based fiber-optic engine control system was developed to provide precise control over valve and ignition timing. Initial shakedown testing with hydrogen/oxygen mixtures verified the need for Schelkin spirals in both the initiator and primary tubes to ensure rapid development of the detonation wave. Measured pressure wave time-of-flight indicated detonation velocities of 2.4 km/sec and 2.2 km/sec in the initiator and primary tubes, respectively. These values implied a fuel-lean mixture corresponding to an H2 volume fraction near 0.5. The axial distribution for the detonation velocity was found to be essentially constant along the primary tube. Time-resolved thrust profiles were also acquired for both underfilled and overfilled tube conditions. These profiles are consistent with previous time

  9. Comparative analysis of alternative fuels in detonation combustion

    OpenAIRE

    Azami, M. H.; Savill, Mark A.

    2016-01-01

    Detonation combustion prominently exhibits high thermodynamic efficiency which leads to better performance. As compared to the conventionally used isobaric heat addition in a Brayton cycle combustor, detonation uses a novel isochoric Humphrey cycle which utilises shocks and detonation waves to provide pressure-rise combustion. Such unsteady combustion has already been explored in wave rotor, pulse detonation engine and rotating detonation engine configurations as alternative technologies for ...

  10. Numerical Simulation of Aluminum Dust Detonations with Different Product Phases

    Science.gov (United States)

    Teng, H. H.; Jiang, Z. L.

    Detonation waves are waves of supersonic combustion induced by strong coupling shock and heat release. Detonation research has attracted much attention in recent years owing to its potential applications in hypersonic propulsion. Aluminum (Al) particle detonation is a type of dust detonation, and its research is important in the prevention of industrial explosions. Al dust detonations for flake and spherical particles have been studied , which is found to be very sensitive to the specific area[1].

  11. VLW equation of state of detonation products

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Based on the virial theory, we proposed VLW equation of state of detonation products (VLW EOS). Its basic theory and applications were described. The distinct features of the VLW EOS were:First, the detonation performance of the new high energy density materials could be predicted more reliably. Second, it had extensive application. The detonation parameters of both the condensed high energy density materials and the gaseous fuel air explosives could be calculated. Moreover, combustion performance of propellants could also be precisely calculated. The calculation results were satisfactory.

  12. Stability of ZND detonations for Majda's model

    CERN Document Server

    Jung, Soyeun

    2012-01-01

    We evaluate by direct calculation the Lopatinski determinant for ZND detonations in Majda's model for reacting flow, and show that on the nonstable (nonnegative real part) complex half-plane it has a single zero at the origin of multiplicity one, implying stability. Together with results of Zumbrun on the inviscid limit, this recovers the result of RoqueJoffre-Vila that viscous detonations of Majda's model also are stable for sufficiently small viscosity, for any fixed detonation strength, heat release, and rate of reaction.

  13. Cellular Cell Bifurcation of Cylindrical Detonations

    Institute of Scientific and Technical Information of China (English)

    HAN Gui-Lai; JIANG Zong-Lin; WANG Chun; ZHANG Fan

    2008-01-01

    Cellular cell pattern evolution of cylindrically-diverging detonations is numerically simulated successfully by solving two-dimensional Euler equations implemented with an improved two-step chemical kinetic model. From the simulation, three cell bifurcation modes are observed during the evolution and referred to as concave front focusing, kinked and wrinkled wave front instability, and self-merging of cellular cells. Numerical research demonstrates that the wave front expansion resulted from detonation front diverging plays a major role in the cellular cell bifurcation, which can disturb the nonlinearly self-sustained mechanism of detonations and finally lead to cell bifurcations.

  14. Reversible Switching of Cooperating Replicators

    Science.gov (United States)

    Urtel, Georg C.; Rind, Thomas; Braun, Dieter

    2017-02-01

    How can molecules with short lifetimes preserve their information over millions of years? For evolution to occur, information-carrying molecules have to replicate before they degrade. Our experiments reveal a robust, reversible cooperation mechanism in oligonucleotide replication. Two inherently slow replicating hairpin molecules can transfer their information to fast crossbreed replicators that outgrow the hairpins. The reverse is also possible. When one replication initiation site is missing, single hairpins reemerge from the crossbreed. With this mechanism, interacting replicators can switch between the hairpin and crossbreed mode, revealing a flexible adaptation to different boundary conditions.

  15. Therapeutic efficacy of G207, a conditionally replicating herpes simplex virus type 1 mutant, for gallbladder carcinoma in immunocompetent hamsters.

    Science.gov (United States)

    Nakano, K; Todo, T; Chijiiwa, K; Tanaka, M

    2001-04-01

    Gallbladder cancer is an extremely difficult disease to cure once metastases occur. In this paper, we explored the potential of G207, an oncolytic, replication-competent herpes simplex virus type 1 mutant, as a new therapeutic means for gallbladder cancer. Gallbladder carcinoma cell lines (four human and one hamster) showed nearly total cell killing within 72 h of G207 infection at a m.o.i. of 0.25 to 2.5 in vitro. The susceptibility to G207 cytopathic activity correlated with the infection efficiency demonstrated by lacZ expression. Intraneoplastic inoculation of G207 (1 x 10(7) pfu) in immunocompetent hamsters bearing established subcutaneous KIGB-5 tumors caused a significant inhibition of tumor growth and prolongation of survival. Repeated inoculations (three times with 4-day intervals) were significantly more efficacious than a single inoculation. In hamsters with bilateral subcutaneous KIGB-5 tumors, inoculation of one tumor alone with G207 caused regression or growth reduction of uninoculated tumors as well as inoculated tumors. In athymic mice, however, the anti-tumor effect was largely reduced in inoculated tumors and completely abolished in remote tumors, suggesting large contribution of T-cell-mediated immune responses to both local and systemic anti-tumor effect of G207. These results indicate that G207 may be useful as a new strategy for gallbladder cancer treatment.

  16. Database Replication

    CERN Document Server

    Kemme, Bettina

    2010-01-01

    Database replication is widely used for fault-tolerance, scalability and performance. The failure of one database replica does not stop the system from working as available replicas can take over the tasks of the failed replica. Scalability can be achieved by distributing the load across all replicas, and adding new replicas should the load increase. Finally, database replication can provide fast local access, even if clients are geographically distributed clients, if data copies are located close to clients. Despite its advantages, replication is not a straightforward technique to apply, and

  17. Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV.

    Science.gov (United States)

    Tebas, Pablo; Stein, David; Binder-Scholl, Gwendolyn; Mukherjee, Rithun; Brady, Troy; Rebello, Tessio; Humeau, Laurent; Kalos, Michael; Papasavvas, Emmanouil; Montaner, Luis J; Schullery, Daniel; Shaheen, Farida; Brennan, Andrea L; Zheng, Zhaohui; Cotte, Julio; Slepushkin, Vladimir; Veloso, Elizabeth; Mackley, Adonna; Hwang, Wei-Ting; Aberra, Faten; Zhan, Jenny; Boyer, Jean; Collman, Ronald G; Bushman, Frederic D; Levine, Bruce L; June, Carl H

    2013-02-28

    We report the safety and tolerability of 87 infusions of lentiviral vector–modified autologous CD4 T cells (VRX496-T; trade name, Lexgenleucel-T) in 17 HIV patients with well-controlled viremia. Antiviral effects were studied during analytic treatment interruption in a subset of 13 patients. VRX496-T was associated with a decrease in viral load set points in 6 of 8 subjects (P = .08). In addition, A → G transitions were enriched in HIV sequences after infusion, which is consistent with a model in which transduced CD4 T cells exert antisense-mediated genetic pressure on HIV during infection. Engraftment of vector-modified CD4 T cells was measured in gut-associated lymphoid tissue and was correlated with engraftment in blood. The engraftment half-life in the blood was approximately 5 weeks, with stable persistence in some patients for up to 5 years. Conditional replication of VRX496 was detected periodically through 1 year after infusion. No evidence of clonal selection of lentiviral vector–transduced T cells or integration enrichment near oncogenes was detected. This is the first demonstration that gene-modified cells can exert genetic pressure on HIV. We conclude that gene-modified T cells have the potential to decrease the fitness of HIV-1 and conditionally replicative lentiviral vectors have a promising safety profile in T cells.

  18. Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses

    Science.gov (United States)

    Vyleta, Nicholas P; Borges-Merjane, Carolina; Jonas, Peter

    2016-01-01

    Mossy fiber synapses on CA3 pyramidal cells are 'conditional detonators' that reliably discharge postsynaptic targets. The 'conditional' nature implies that burst activity in dentate gyrus granule cells is required for detonation. Whether single unitary excitatory postsynaptic potentials (EPSPs) trigger spikes in CA3 neurons remains unknown. Mossy fiber synapses exhibit both pronounced short-term facilitation and uniquely large post-tetanic potentiation (PTP). We tested whether PTP could convert mossy fiber synapses from subdetonator into detonator mode, using a recently developed method to selectively and noninvasively stimulate individual presynaptic terminals in rat brain slices. Unitary EPSPs failed to initiate a spike in CA3 neurons under control conditions, but reliably discharged them after induction of presynaptic short-term plasticity. Remarkably, PTP switched mossy fiber synapses into full detonators for tens of seconds. Plasticity-dependent detonation may be critical for efficient coding, storage, and recall of information in the granule cell–CA3 cell network. DOI: http://dx.doi.org/10.7554/eLife.17977.001 PMID:27780032

  19. Qualitative and Asymptotic Theory of Detonations

    KAUST Repository

    Faria, Luiz

    2014-11-09

    Shock waves in reactive media possess very rich dynamics: from formation of cells in multiple dimensions to oscillating shock fronts in one-dimension. Because of the extreme complexity of the equations of combustion theory, most of the current understanding of unstable detonation waves relies on extensive numerical simulations of the reactive compressible Euler/Navier-Stokes equations. Attempts at a simplified theory have been made in the past, most of which are very successful in describing steady detonation waves. In this work we focus on obtaining simplified theories capable of capturing not only the steady, but also the unsteady behavior of detonation waves. The first part of this thesis is focused on qualitative theories of detonation, where ad hoc models are proposed and analyzed. We show that equations as simple as a forced Burgers equation can capture most of the complex phenomena observed in detonations. In the second part of this thesis we focus on rational theories, and derive a weakly nonlinear model of multi-dimensional detonations. We also show, by analysis and numerical simulations, that the asymptotic equations provide good quantitative predictions.

  20. Deflagration to Detonation Transition in Thermonuclear Supernovae

    CERN Document Server

    Khokhlov, A M; Wheeler, J C

    1996-01-01

    We derive the criteria for deflagration to detonation transition (DDT) in a Type Ia supernova. The theory is based on the two major assumptions: (i) detonation is triggered via the Zeldovich gradient mechanism inside a region of mixed fuel and products, (ii) the mixed region is produced by a turbulent mixing of fuel and products either inside an active deflagration front or during the global expansion and subsequent contraction of an exploding white dwarf. We determine the critical size of the mixed region required to initiate a detonation in a degenerate carbon-oxygen mixture. This critical length is much larger than the width of the reaction front of a Chapman-Jouguet detonation. However, at densities greater than simeq 5 x 10^6 g cm^-3, it is much smaller than the size of a white dwarf. We derive the critical turbulent intensity required to create the mixed region inside an active deflagration front in which a detonation can form. We conclude that the density rho_tr at which a detonation can form in a carb...

  1. Effect of Resolution on Propagating Detonation Wave

    Energy Technology Data Exchange (ETDEWEB)

    Menikoff, Ralph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-07-10

    Simulations of the cylinder test are used to illustrate the effect of mesh resolution on a propagating detonation wave. For this study we use the xRage code with the SURF burn model for PBX 9501. The adaptive mesh capability of xRage is used to vary the resolution of the reaction zone. We focus on two key properties: the detonation speed and the cylinder wall velocity. The latter is related to the release isentrope behind the detonation wave. As the reaction zone is refined (2 to 15 cells for cell size of 62 to 8μm), both the detonation speed and final wall velocity change by a small amount; less than 1 per cent. The detonation speed decreases with coarser resolution. Even when the reaction zone is grossly under-resolved (cell size twice the reaction-zone width of the burn model) the wall velocity is within a per cent and the detonation speed is low by only 2 per cent.

  2. Detonating Cord for Flux Compression Generation using Electrical Detonator No. 33

    Directory of Open Access Journals (Sweden)

    P B. Wagh

    2011-01-01

    Full Text Available The paper highlights the use of electrical detonators for magnetic flux compression generator applications which requires synchronisation of two events with precise time delay of tens of ms and jitter within a few ms. These requirements are generally achieved by exploding bridge wire type detonators which are difficult to develop and are not commercially available. A technique has been developed using commercially available electrical detonator no. 33 to synchronise between peak of seed current in stator coil and detonation of explosive charge in armature. In present experiments, electrical signal generated by self-shorting pin due to bursting of electrical detonator has been used to trigger the capacitor discharge and the detonating cord of known length has been used to incorporate predetermined delay to synchronise the events. It has been demonstrated that using electrical detonator and known length of detonating cord, the two events can be synchronised with predetermined delay between 31 and 251 ms with variation of ± 0.5ms. The technique developed is suitable for defence applications like generation of high power microwaves using explosive driven magnetic flux compression generators.Defence Science Journal, 2011, 61(1, pp.19-24, DOI:http://dx.doi.org/10.14429/dsj.61.30

  3. Detonability of H/sub 2/-air-diluent mixtures

    Energy Technology Data Exchange (ETDEWEB)

    Tieszen, S.R.; Sherman, M.P.; Benedick, W.B.; Berman, M.

    1987-06-01

    This report describes the Heated Detonation Tube (HDT). Detonation cell width and velocity results are presented for H/sub 2/-air mixtures, undiluted and diluted with CO/sub 2/ and H/sub 2/O for a range of H/sub 2/ concentration, initial temperature and pressure. The results show that the addition of either CO/sub 2/ or H/sub 2/O significantly increases the detonation cell width and hence reduces the detonability of the mixture. The results also show that the detonation cell width is reduced (detonability is increased) for increased initial temperature and/or pressure.

  4. Gaseous detonation synthesis and characterization of nano-oxide

    Science.gov (United States)

    Yan, Honghao; Wu, Linsong; Li, Xiaojie; Wang, Xiaohong

    2015-07-01

    Gaseous detonation is a new method of heating the precursor of nanomaterials into gas, and integrating it with combustible gas as mixture to be detonated for the synthesis of nanomaterials. In this paper, the mixed gas of oxygen and hydrogen is used as the source for detonation, to synthesize nano TiO2, nano SiO2 and nano SnO2 through gaseous detonation method, characterization and analysis of the products, it was found that the products from gaseous detonation method were of high purity, good dispersion, smaller particle size and even distribution. It also shows that for the synthesis of nano-oxides, gaseous detonation is universal.

  5. Study of detonation initiation in kerosene-oxidizer mixtures in short tubes

    Science.gov (United States)

    Kindracki, J.

    2014-11-01

    The paper describes experimental studies of detonation initiation in a kerosene-oxidizer mixture in a short test tube. The aim of the study is to determine the minimum diameter of the tube and the minimum level of energy that enables direct initiation of the detonation. Knowledge about these values will inform the design of a jet engine combustion chamber in which thermal energy will be generated by a rotating detonation process. The test tube and the oxidizer inside the tube were heated using specially designed heaters installed outside of the tube. The heated oxidizer provided thermal conditions similar to the conditions for a compressor with small to medium static pressure. The study was conducted for four different tube diameters and for various energies of initiation. As a result, measurements of pressure waveforms were obtained for various cases of fuel injection, which were then compared against the results of the shock wave generated by the initiator. This study provides a value for the energy (the pressure of the mixture in the initiator), which provided direct initiation of detonation for a kerosene-oxidizer mixture. Different tube diameters led to the initiation of detonation for various oxygen-nitrogen compositions as an oxidizer.

  6. A thermochemical model for shock-induced reactions (heat detonations) in solids

    Energy Technology Data Exchange (ETDEWEB)

    Boslough, M.B. (Sandia National Laboratories, Albuquerque, New Mexico 87185 (US))

    1990-02-01

    Recent advances in studies of shock-induced chemistry in reactive solids have led to the recognition of a new class of energetic materials which are unique in their response to shock waves. Experimental work has shown that chemical energy can be released on a time scale shorter than shock-transit times in laboratory samples. However, for many compositions, the reaction products remain in the condensed state upon release from high pressure, and no sudden expansion takes place. Nevertheless, if such a reaction is sufficiently rapid, it can be modeled as a type of detonation, termed heat detonation'' in the present paper. It is shown that unlike an explosive detonation, an unsupported heat detonation will decay to zero unless certain conditions are met. An example of such a reaction is Fe{sub 2}O{sub 3} +2Al+shock{r arrow}Al{sub 2} O{sub 3} +2Fe (the standard thermite reaction). A shock-wave equation of state is determined from a mixture theory for reacted and unreacted porous thermite. The calculated shock temperatures are compared to experimentally measured shock temperatures, demonstrating that a shock-induced reaction takes place. Interpretation of the measured temperature history in the context of the thermochemical model implies that the principal rate-controlling kinetic mechanism is dynamic mixing at the shock front. Despite the similarity in thermochemical modeling of heat detonations to explosive detonations, the two processes are qualitatively very different in reaction mechanism as well as in the form the energy takes upon release, with explosives producing mostly work and heat detonations producing mostly heat.

  7. Beyond the bubble catastrophe of Type Ia supernovae: Pulsating Reverse Detonation models

    CERN Document Server

    Bravo, E; Bravo, Eduardo; Garcia-Senz, Domingo

    2006-01-01

    We describe a mechanism by which a failed deflagration of a Chandrasekhar-mass carbon-oxygen white dwarf can turn into a successful thermonuclear supernova explosion, without invoking an ad hoc high-density deflagration-detonation transition. Following a pulsating phase, an accretion shock develops above a core of 1 M_sun composed of carbon and oxygen, inducing a converging detonation. A three-dimensional simulation of the explosion produced a kinetic energy of 1.05E51 ergs and 0.70 M_sun of 56Ni, ejecting scarcely 0.01 M_sun of C-O moving at low velocities. The mechanism works under quite general conditions and is flexible enough to account for the diversity of normal Type Ia supernovae. In given conditions the detonation might not occur, which would reflect in peculiar signatures in the gamma and UV-wavelengths

  8. Review on Recent Advances in Pulse Detonation Engines

    Directory of Open Access Journals (Sweden)

    K. M. Pandey

    2016-01-01

    Full Text Available Pulse detonation engines (PDEs are new exciting propulsion technologies for future propulsion applications. The operating cycles of PDE consist of fuel-air mixture, combustion, blowdown, and purging. The combustion process in pulse detonation engine is the most important phenomenon as it produces reliable and repeatable detonation waves. The detonation wave initiation in detonation tube in practical system is a combination of multistage combustion phenomena. Detonation combustion causes rapid burning of fuel-air mixture, which is a thousand times faster than deflagration mode of combustion process. PDE utilizes repetitive detonation wave to produce propulsion thrust. In the present paper, detailed review of various experimental studies and computational analysis addressing the detonation mode of combustion in pulse detonation engines are discussed. The effect of different parameters on the improvement of propulsion performance of pulse detonation engine has been presented in detail in this research paper. It is observed that the design of detonation wave flow path in detonation tube, ejectors at exit section of detonation tube, and operating parameters such as Mach numbers are mainly responsible for improving the propulsion performance of PDE. In the present review work, further scope of research in this area has also been suggested.

  9. Detonation nanodiamonds for doping Kevlar.

    Science.gov (United States)

    Comet, Marc; Pichot, Vincent; Siegert, Benny; Britz, Fabienne; Spitzer, Denis

    2010-07-01

    This paper reports on the first attempt to enclose diamond nanoparticles--produced by detonation--into a Kevlar matrix. A nanocomposite material (40 wt% diamond) was prepared by precipitation from an acidic solution of Kevlar containing dispersed nanodiamonds. In this material, the diamond nanoparticles (Ø = 4 nm) are entirely wrapped in a Kevlar layer about 1 nm thick. In order to understand the interactions between the nanodiamond surface and the polymer, the oxygenated surface functional groups of nanodiamond were identified and titrated by Boehm's method which revealed the exclusive presence of carboxyl groups (0.85 sites per nm2). The hydrogen interactions between these groups and the amide groups of Kevlar destroy the "rod-like" structure and the classical three-dimensional organization of this polymer. The distortion of Kevlar macromolecules allows the wrapping of nanodiamonds and leads to submicrometric assemblies, giving a cauliflower structure reminding a fractal object. Due to this structure, the macroscopic hardness of Kevlar doped by nanodiamonds (1.03 GPa) is smaller than the one of pure Kevlar (2.31 GPa). To our knowledge, this result is the first illustration of the change of the mechanical properties induced by doping the Kevlar with nanoparticles.

  10. Detonation-synthesis nanodiamonds: synthesis, structure, properties and applications

    Energy Technology Data Exchange (ETDEWEB)

    Dolmatov, Valerii Yu [Federal State Unitary Enterprise Special Design-Technology Bureau (FSUE SDTB) ' ' Tekhnolog' ' at the St Petersburg State Institute of Technology (Technical University) (Russian Federation)

    2007-04-30

    The review outlines the theoretical foundations and industrial implementations of modern detonation synthesis of nanodiamonds and chemical purification of the nanodiamonds thus obtained. The structure, key properties and promising fields of application of detonation-synthesis nanodiamonds are considered.

  11. Double detonation drivers for a shock tube/tunnel

    Institute of Scientific and Technical Information of China (English)

    CHEN; Hong; FENG; Heng; YU; Hongru

    2004-01-01

    Recent progress on detonation drivers is reviewed. Performances of the forward detonation driver and backward detonation driver have been observed. To eliminate occurrence of a Taylor wave following the detonation wave in the primary driver and to improve the performance of the detonation driver, an additional backward detonation driver was proposed to attach to the end of the forward detonation driver.When the ratio of the initial pressures between the additional and the primary drivers becomes larger than or equal to a critical value, the Taylor wave will disappear, and thus a homogeneous driving gas with high pressure and high temperature can be generated.Furthermore, an over-driving detonation wave will be also obtained, which can increase the driving capability.

  12. Research on the Low Detonation Velocity Explosives Containing Nitroesters

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Some explosive mixtures detonating at low velocity were experimentally investigated. Detonation velocity and critical diameter were measured for mixtures,being different in composition and density. An attempt of physical and chemical interpretation of results obtained is also included.

  13. Numerical modelling of continuous spin detonation in rich methane-oxygen mixture

    Science.gov (United States)

    Trotsyuk, A. V.

    2016-10-01

    A numerical simulation of a two-dimensional structure of the detonation wave (DW) in a rich (equivalence ratio φ=1.5) methane-air mixture at normal initial condition has been conducted. The computations have been performed in a wide range of channel heights. From the analysis of the flow structure and the number of primary transverse waves in the channel, the dominant size of the detonation cell for studied mixture has been determined to be 45÷50 cm. Based on the fundamental studies of multi-front (cellular) structure of the classical propagating DW in methane mixtures, numerical simulation of continuous spin detonation (CSD) of rich (φ=1.2) methane-oxygen mixture has been carried out in the cylindrical detonation chamber (DC) of the rocket-type engine. We studied the global flow structure in DC, and the detailed structure of the front of the rotating DW. Integral characteristics of the detonation process - the distribution of average values of static and total pressure along the length of the DC, and the value of specific impulse have been obtained. The geometric limit of stable existence of CSD has been determined.

  14. Characterizing the growth to detonation in PETN and HNS with small-scale PDV cutback experiments

    Science.gov (United States)

    Wixom, Ryan; Yarrington, Cole; Knepper, Robert; Tappan, Alexander; Olles, Joseph; Zelenok, Matthew; A-Team

    2015-06-01

    For many decades, cutback experiments have been used to characterize the equation of state and growth to steady detonation in explosive formulations. More recently, embedded gauges have been used to capture the growth to steady detonation in gas-gun impacted samples. Data resulting from these experiments are extremely valuable for parameterizing equation of state and reaction models used in hydrocode simulations. Due to the extremely fast growth to detonation in typical detonator explosives, cutback and embedded gauge experiments are extremely difficult, if not impossible. Using frequency shifted photonic Doppler velocimetry (PDV) we have measured particle velocity histories from explosive films impacted with electrically driven flyers. By varying the sample thickness and impact conditions we were able to capture the growth from inert shock to full detonation pressure within distances as short as 100 μm. These data were used to assess and improve burn-model parameterization and equations of state for simulating shock initiation. Additionally, we discuss details of the experiment and data analysis regarding the most accurate possible determination of the velocity spike.

  15. A Subgrid-scale Model for Deflagration-to-Detonation Transitions in Type Ia Supernova Explosion Simulations - Numerical implementation

    CERN Document Server

    Ciaraldi-Schoolmann, F; Roepke, F K

    2013-01-01

    A promising model for normal Type Ia supernova (SN Ia) explosions are delayed detonations of Chandrasekhar-mass white dwarfs, in which the burning starts out as a subsonic deflagration and turns at a later phase of the explosion into a supersonic detonation. The mechanism of the underlying deflagration-to-detonation transition (DDT) is unknown in detail, but necessary conditions have been determined recently. The region of detonation initiation cannot be spatially resolved in multi-dimensional full-star simulations of the explosion. We develop a subgrid-scale (SGS) model for DDTs in thermonuclear supernova simulations that is consistent with the currently known constraints. The probability for a DDT to occur is calculated from the distribution of turbulent velocities measured on the grid scale in the vicinity of the flame and the fractal flame surface area that satisfies further physical constraints, such as fuel fraction and fuel density. The implementation of our DDT criterion provides a solid basis for sim...

  16. Linear elastic response of tubes to internal detonation loading

    NARCIS (Netherlands)

    Beltman, W.M.; Shepherd, J.E.

    2002-01-01

    This paper deals with the structural response of a tube to an internal gaseous detonation. An internal detonation produces a pressure load that propagates down the tube. Because the speed of the gaseous detonation can be comparable to the flexural wave group speed, excitation of flexural waves in th

  17. Stream of Reaction Products behind the Detonation Wave Front

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Embedded copper foils in a high explosive charge allow to see the stream of the reaction products behind the detonation front. With three individual firings in front of FXR it can be shown that the reaction products behind the detonation front are immediately going in the direction of the detonation front. But then the rarefaction fans are influencing strongly the further displacements.

  18. 30 CFR 75.1311 - Transporting explosives and detonators.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Transporting explosives and detonators. 75.1311... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Explosives and Blasting § 75.1311 Transporting explosives and detonators. (a) When explosives and detonators are to be transported underground...

  19. 30 CFR 56.6402 - Deenergized circuits near detonators.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Deenergized circuits near detonators. 56.6402... Electric Blasting § 56.6402 Deenergized circuits near detonators. Electrical distribution circuits within 50 feet of electric detonators at the blast site shall be deenergized. Such circuits need not...

  20. 30 CFR 57.6402 - Deenergized circuits near detonators.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Deenergized circuits near detonators. 57.6402... Electric Blasting-Surface and Underground § 57.6402 Deenergized circuits near detonators. Electrical distribution circuits within 50 feet of electric detonators at the blast site shall be deenergized....

  1. Detonation Properties of Ammonium Dinitramide (ADN)

    Science.gov (United States)

    Wätterstam, A.; Östmark, H.; Helte, A.; Karlsson, S.

    1999-06-01

    Ammonium Dinitramide, ADN, has a potential as an oxidizer for underwater high explosives. Pure ADN has a large reaction-zone length and shows a strong non-ideal behaviour. The work presented here is an extension of previous work.(Sensitivity and Performance Characterization of Ammonium Dinitramide (ADN). Presented at 11th International Detonation Symposium, Snowmass, CO, 1998.) Experiments for determining the detonation velocity as a function of inverse charge radius and density, reaction-zone length and curvature, and the detonation pressure are presented. Measurements of pressure indicates that no, or weak von-Neumann spike exists, suggesting an immediate chemical decomposition. Experimental data are compared with predicted using thermochemical codes and ZND-theory.

  2. Detonation Performance Testing of LX-19

    Science.gov (United States)

    Vincent, Samuel; Aslam, Tariq; Jackson, Scott

    2015-06-01

    CL-20 was developed at the Naval Surface Weapons Center at China Lake, CA in the mid 80's. Being less sensitive than PETN, but considerably more powerful than HMX, it is the highest energy and density compound known among organic chemicals. LX-19 was developed at LLNL in the early 90's. It is a high-energy plastic bonded explosive, composed of 95.8 wt% CL-20 and 4.2 wt% Estane binder, and is similar to LX-14 (composed of HMX and Estane), but with greater sensitivity characteristics with use of the more energetic CL-20 explosive. We report detonation performance results for unconfined cylindrical rate sticks of LX-19. The experimental diameter effects are shown, along with detonation front shapes, and reaction zone profiles for different test diameters. This data is critical for calibration to Detonation Shock Dynamics (DSD). LA-UR-15-20672.

  3. Multistage reaction pathways in detonating RDX

    Science.gov (United States)

    Li, Ying; Kalia, Rajiv K.; Nakano, Aiichiro; Vashishta, Priya

    2017-01-01

    Atomistic mechanisms underlying the reaction time and intermediate reaction products of detonating high explosives far from equilibrium have been elusive. This is because detonation is one of the hardest multiscale physics problems, in which diverse length and time scales play important roles. Here, large spatiotemporal-scale reactive molecular dynamics simulations validated by quantum molecular dynamics simulations reveal a two-stage reaction mechanism during the detonation of cyclotrimethylenetrinitramine cystal. Rapid production of N2 and H2O within ˜10 ps is followed by delayed production of CO molecules beyond ns. We found that further decomposition towards the final products is inhibited by the formation of large metastable carbon- and oxygen- rich clusters with fractal geometry. In addition, we found distinct unimolecular and intermolecular reaction pathways, respectively, for the rapid N2 and H2O productions.

  4. Transmission electron microscopy and x-ray diffraction studies of the detonation soot of high explosives

    Science.gov (United States)

    Kashkarov, A. O.; Pruuel, E. R.; Ten, K. A.; Rubtsov, I. A.; Gerasimov, E. Yu; Zubkov, P. I.

    2016-11-01

    This paper presents the results of electron microscopy and x-ray diffraction studies of the recovered carbonaceous residue (soot) from the detonation of some high explosives: TNT, a mixture of TNT and RDX (50/50), benzotrifuroxane, and triaminotrinitrobenzene. The use of the same experimental setup allowed a qualitative and quantitative comparison of the detonation products formed under similar conditions. The results clearly show differences in the morphology of graphite-like and diamond inclusions and in the quantitative content of nanodiamonds for the explosives used in this study.

  5. Shock-Wave and Detonation Studies at ITEP-TWAC Proton Radiography Facility

    Science.gov (United States)

    Kolesnikov, Sergey; Dudin, Sergey; Lavrov, Vladimir; Nikolaev, Dmitry; Mintsev, Victor; Shilkin, Nikolay; Ternovoi, Vladimir; Utkin, Alexander; Yakushev, Vladislav; Yuriev, Denis; Fortov, Vladimir; Golubev, Alexander; Kantsyrev, Alexey; Shestov, Lev; Smirnov, Gennady; Turtikov, Vladimir; Sharkov, Boris; Burtsev, Vasily; Zavialov, Nikolay; Kartanov, Sergey; Mikhailov, Anatoly; Rudnev, Alexey; Tatsenko, Mikhail; Zhernokletov, Mikhail

    2011-06-01

    In recent years studies of shock and detonation wave phenomena at extreme dynamic conditions were performed at proton radiography facility developed at the 800 MeV proton beam line of ITEP Terawatt Accelerator (ITEP-TWAC). The facility provides a multi-frame imaging capability at 50 μm spatial and 70 ns temporal resolution. The results of latest studies conducted there are presented, including explosion and detonation of pressed and emulsion high explosives, shock-induced dense non-ideal plasma of argon and xenon and shock loading of non-uniform metal surfaces. New compact explosive generators developed specifically for a use at proton radiography facilities are also presented.

  6. Shockwave and detonation studies at ITEP-TWAC proton radiography facility

    Science.gov (United States)

    Kolesnikov, Sergey; Dudin, Sergey; Lavrov, Vladimir; Nikolaev, Dmitry; Mintsev, Victor; Shilkin, Nikolay; Ternovoi, Vladimir; Utkin, Alexander; Yakushev, Vladislav; Yuriev, Denis; Fortov, Vladimir; Golubev, Alexander; Kantsyrev, Alexey; Shestov, Lev; Smirnov, Gennady; Turtikov, Vladimir; Sharkov, Boris; Burtsev, Vasily; Zavialov, Nikolay; Kartanov, Sergey; Mikhailov, Anatoly; Rudnev, Alexey; Tatsenko, Mikhail; Zhernokletov, Mikhail

    2012-03-01

    In recent years studies of shock and detonation wave phenomena at extreme dynamic conditions were performed at proton radiography facility developed at the 800 MeV proton beam line of ITEP Terawatt Accelerator (ITEP-TWAC). The facility provides a multi-frame imaging capability at 50 μm spatial and 70 ns temporal resolution. The results of latest studies conducted there are presented, including explosion and detonation of pressed and emulsion high explosives, shock-induced dense non-ideal plasma of argon and xenon and shock loading of non-uniform metal surfaces. New compact explosive generators developed specifically for a use at proton radiography facilities are also presented.

  7. Detonation onset following shock wave focusing

    Science.gov (United States)

    Smirnov, N. N.; Penyazkov, O. G.; Sevrouk, K. L.; Nikitin, V. F.; Stamov, L. I.; Tyurenkova, V. V.

    2017-06-01

    The aim of the present paper is to study detonation initiation due to focusing of a shock wave reflected inside a cone. Both numerical and experimental investigations were conducted. Comparison of results made it possible to validate the developed 3-d transient mathematical model of chemically reacting gas mixture flows incorporating hydrogen - air mixtures. The results of theoretical and numerical experiments made it possible improving kinetic schemes and turbulence models. Several different flow scenarios were detected in reflection of shock waves all being dependent on incident shock wave intensity: reflecting of shock wave with lagging behind combustion zone, formation of detonation wave in reflection and focusing, and intermediate transient regimes.

  8. Equilibrium and stability properties of detonation waves in the hydrodynamic limit of a kinetic model

    Science.gov (United States)

    Marques, Wilson, Jr.; Jacinta Soares, Ana; Pandolfi Bianchi, Miriam; Kremer, Gilberto M.

    2015-06-01

    A shock wave structure problem, like the one which can be formulated for the planar detonation wave, is analyzed here for a binary mixture of ideal gases undergoing the symmetric reaction {{A}1}+{{A}1}\\rightleftharpoons {{A}2}+{{A}2}. The problem is studied at the hydrodynamic Euler limit of a kinetic model of the reactive Boltzmann equation. The chemical rate law is deduced in this frame with a second-order reaction rate, in a chemical regime such that the gas flow is not far away from the chemical equilibrium. The caloric and the thermal equations of state for the specific internal energy and temperature are employed to close the system of balance laws. With respect to other approaches known in the kinetic literature for detonation problems with a reversible reaction, this paper aims to improve some aspects of the wave solution. Within the mathematical analysis of the detonation model, the equation of the equilibrium Hugoniot curve of the final states is explicitly derived for the first time and used to define the correct location of the equilibrium Chapman-Jouguet point in the Hugoniot diagram. The parametric space is widened to investigate the response of the detonation solution to the activation energy of the chemical reaction. Finally, the mathematical formulation of the linear stability problem is given for the wave detonation structure via a normal-mode approach, when bidimensional disturbances perturb the steady solution. The stability equations with their boundary conditions and the radiation condition of the considered model are explicitly derived for small transversal deviations of the shock wave location. The paper shows how a second-order chemical kinetics description, derived at the microscopic level, and an analytic deduction of the equilibrium Hugoniot curve, lead to an accurate picture of the steady detonation with reversible reaction, as well as to a proper bidimensional linear stability analysis.

  9. On detonation dynamics in hydrogen-air-steam mixtures: Theory and application to Olkiluoto reactor building

    Energy Technology Data Exchange (ETDEWEB)

    Silde, A.; Lindholm, I. [VTT Energy, Espoo (Finland)

    2000-02-01

    This report consists of the literature study of detonation dynamics in hydrogen-air-steam mixtures, and the assessment of shock pressure loads in Olkiluoto 1 and 2 reactor building under detonation conditions using the computer program DETO developed during this work at VTT. The program uses a simple 1-D approach based on the strong explosion theory, and accounts for the effects of both the primary or incident shock and the first (oblique or normal) reflected shock from a wall structure. The code results are also assessed against a Balloon experiment performed at Germany, and the classical Chapman-Jouguet detonation theory. The whole work was carried out as a part of Nordic SOS-2.3 project, dealing with severe accident analysis. The initial conditions and gas distribution of the detonation calculations are based on previous severe accident analyses by MELCOR and FLUENT codes. According to DETO calculations, the maximum peak pressure in a structure of Olkiluoto reactor building room B60-80 after normal shock reflection was about 38.7 MPa if a total of 3.15 kg hydrogen was assumed to burned in a distance of 2.0 m from the wall structure. The corresponding pressure impulse was about 9.4 kPa-s. The results were sensitive to the distance used. Comparison of the results to classical C-J theory and the Balloon experiments suggested that DETO code represented a conservative estimation for the first pressure spike under the shock reflection from a wall in Olkiluoto reactor building. Complicated 3-D phenomena of shock wave reflections and focusing, nor the propagation of combustion front behind the shock wave under detonation conditions are not modeled in the DETO code. More detailed 3-D analyses with a specific detonation code are, therefore, recommended. In spite of the code simplifications, DETO was found to be a beneficial tool for simple first-order assessments of the structure pressure loads under the first reflection of detonation shock waves. The work on assessment

  10. The Principal Aspects of Application of Detonation in Propulsion Systems

    Directory of Open Access Journals (Sweden)

    A. A. Vasil'ev

    2013-01-01

    Full Text Available The basic problems of application of detonation process in propulsion systems with impulse and continuous burning of combustible mixture are discussed. The results on propagation of detonation waves in supersonic flow are analyzed relatively to air-breathing engine. The experimental results are presented showing the basic possibility of creation of an engine with exterior detonation burning. The base results on optimization of initiation in impulse detonation engine are explained at the expense of spatial and temporal redistribution of an energy, entered into a mixture. The method and technique for construction of highly effective accelerators for deflagration to detonation transition are discussed also.

  11. Detonation performance of high-dense BTF charges

    Science.gov (United States)

    Dolgoborodov, A.; Brazhnikov, M.; Makhov, M.; Gubin, S.; Maklashova, I.

    2014-05-01

    New experimental data on detonation wave parameters and explosive performance for benzotrifuroxan are presented. Optical pyrometry was applied in order to measure the temperature and pressure of BTF detonation products. Chapman-Jouguet temperature was obtained as 3990 - 4170 K (charge densities 1.82 - 1.84 g/cc). The heat of explosion and the acceleration ability were measured also. It is also considered the hypothesis of formation of nanodiamond particles in detonation products directly behind the detonation front and influence of these processes on the temperature-time history in detonation products.

  12. Study of the Detonation Phase in the Gravitationally Confined Detonation Model of Type Ia Supernovae

    CERN Document Server

    Meakin, Casey A; Townsley, Dean; Jordan, George C; Truran, James; Lamb, Don

    2008-01-01

    We study the gravitationally confined detonation (GCD) model of Type Ia supernovae through the detonation phase and into homologous expansion. In the GCD model, a detonation is triggered by the surface flow due to single point, off-center flame ignition in carbon-oxygen white dwarfs. The simulations are unique in terms of the degree to which non-idealized physics is used to treat the reactive flow, including weak reaction rates and a time dependent treatment of material in nuclear statistical equilibrium (NSE). Careful attention is paid to accurately calculating the final composition of material which is burned to NSE and frozen out in the rapid expansion following the passage of a detonation wave over the high density core of the white dwarf; and an efficient method for nucleosynthesis post-processing is developed which obviates the need for costly network calculations along tracer particle thermodynamic trajectories. Observational diagnostics are presented for the explosion models, including abundance strat...

  13. Effect of detonation nanodiamonds on phagocyte activity.

    Science.gov (United States)

    Karpukhin, Alexey V; Avkhacheva, Nadezhda V; Yakovlev, Ruslan Yu; Kulakova, Inna I; Yashin, Valeriy A; Lisichkin, Georgiy V; Safronova, Valentina G

    2011-07-01

    Detonation ND (nanodiamond) holds much promise for biological studies and medical applications. Properties like size of particles, inclination for modification of their surface and unambiguous biocompatibility are crucial. Of prime importance is interaction between ND and immune cells, which supervise foreign intrusion into an organism and eliminate it. Neutrophils are more reactive in inflammatory response implementing cytotoxical arsenal including ROS (reactive oxygen species). The aim of the work was to estimate the ability of two ND samples (produced by Diamond Center and PlasmaChem) to keep the vitality of neutrophils from the inflammatory site. The ability of cells to generate ROS in the presence of ND particles is considered as indicating their biocompatibility. IR spectra and size of particles in the samples were characterized. Acid modification of ND was carried out to get the luminescent form. In the biological aspect, ND demonstrated up or down action, depending on the concentration, time and conditions of activation of cells. Weak action of ND in whole blood was obtained possibly owing to the ND adsorbed plasma proteins, which mask active functional groups to interact with the cell membrane. ND did not influence the viability of isolated inflammatory neutrophils in low and moderate concentrations and suppressed it in high concentrations (≥1 g/l). Addition of ND to the cell suspension initiated concentration-dependent reaction to produce ROS similar to respiratory burst. ND up-regulated response to bacterial formylpeptide, but up- and down-modified (low or high concentrations, accordingly) response to such bacterial agents as OZ (opsonized zymosan), which neutrophils swallow up by oxygen-dependent phagocytosis. Localization of the particles on the cell surface as into the cells was identified by monitoring the intrinsic fluorescence of oxidized ND. The various mechanisms that could account for penetration of ND particles into the cell are discussed

  14. Hydrogen detonation and detonation transition data from the High-Temperature Combustion Facility

    Energy Technology Data Exchange (ETDEWEB)

    Ciccarelli, G.; Boccio, J.L.; Ginsberg, T.; Finfrock, C. [Brookhaven National Lab., Upton, NY (United States)] [and others

    1996-03-01

    The BNL High-Temperature Combustion Facility (HTCF) is an experimental research tool capable of investigating the effects of initial thermodynamic state on the high-speed combustion characteristic of reactive gas mixtures. The overall experimental program has been designed to provide data to help characterize the influence of elevated gas-mixture temperature (and pressure) on the inherent sensitivity of hydrogen-air-steam mixtures to undergo detonation, on the potential for flames accelerating in these mixtures to transition into detonations, on the effects of gas venting on the flame-accelerating process, on the phenomena of initiation of detonations in these mixtures by jets of hot reactant products, and on the capability of detonations within a confined space to transmit into another, larger confined space. This paper presents results obtained from the completion of two of the overall test series that was designed to characterize high-speed combustion phenomena in initially high-temperature gas mixtures. These two test series are the intrinsic detonability test series and the deflagration-to-detonation (DDT) test series. A brief description of the facility is provided below.

  15. Formation of transverse waves in oblique detonations

    NARCIS (Netherlands)

    Verreault, J.; Higgins, A.J.; Stowe, R.A.

    2013-01-01

    The structure of oblique detonation waves stabilized on a hypersonic wedge in mixtures characterized by a large activation energy is investigated via steady method of characteristics (MoC) calculations and unsteady computational flowfield simulations. The steady MoC solutions show that, after the tr

  16. Detonation characteristics of ammonium nitrate products

    NARCIS (Netherlands)

    Kersten, R.J.A.; Hengel, E.I.V. van den; Steen, A.C. van der

    2006-01-01

    The detonation properties of ammonium nitrate (AN) products depend on many factors and are therefore, despite the large amount of information on this topic, difficult to assess. In order to further improve the understanding of the safety properties of AN, the European Fertilizer Manufacturers Associ

  17. Formation of transverse waves in oblique detonations

    NARCIS (Netherlands)

    Verreault, J.; Higgins, A.J.; Stowe, R.A.

    2013-01-01

    The structure of oblique detonation waves stabilized on a hypersonic wedge in mixtures characterized by a large activation energy is investigated via steady method of characteristics (MoC) calculations and unsteady computational flowfield simulations. The steady MoC solutions show that, after the tr

  18. Fast Hydrogen-Air Flames for Turbulence Driven Deflagration to Detonation Transition

    Science.gov (United States)

    Chambers, Jessica; Ahmed, Kareem

    2016-11-01

    Flame acceleration to Detonation produces several combustion modes as the Deflagration-to-Detonation Transition (DDT) is initiated, including fast deflagration, auto-ignition, and quasi-detonation. Shock flame interactions and turbulence levels in the reactant mixture drive rapid flame expansion, formation of a leading shockwave and post-shock conditions. An experimental study to characterize the developing shock and flame front behavior of propagating premixed hydrogen-air flames in a square channel is presented. To produce each flame regime, turbulence levels and flame propagation velocity are controlled using perforated plates in several configurations within the experimental facility. High speed optical diagnostics including Schlieren and Particle Image Velocimetry are used to capture the flow field. In-flow pressure measurements acquired post-shock, detail the dynamic changes that occur in the compressed gas directly ahead of the propagating flame. Emphasis on characterizing the turbulent post-shock environment of the various flame regimes helps identify the optimum conditions to initiate the DDT process. The study aims to further the understanding of complex physical mechanisms that drive transient flame conditions for detonation initiation. American Chemical Society.

  19. Conditioned blocking and schizophrenia: a replication and study of the role of symptoms, age, onset-age of psychosis and illness-duration.

    Science.gov (United States)

    Bender, S; Müller, B; Oades, R D; Sartory, G

    2001-04-15

    Measures of selective attention processing like latent inhibition (LI) and conditioned blocking (CB) are disturbed in some patients with schizophrenia. [LI is the delay in learning about the associations of a stimulus that has been associated with no event (versus de novo learning); CB is the delay in learning the associations of a stimulus-component when the other component has already started to acquire these associations.] We proposed: (1) to replicate the reported decreases of CB in patients without paranoid-hallucinatory symptoms; (2) to see if CB depends on the age of illness-onset and its duration, as reported for LI. We studied 101 young and old, acute and chronically ill patients with schizophrenia, of whom 62 learned a modified 'mouse-in-house' CB task, and compared them with 62 healthy controls matched for age, education and socio-economic background. CB was more evident in patients with a diagnosis of paranoid schizophrenia than other subtypes. An unusual persistence of high CB scores through testing was associated with productive symptoms (including positive thought disorder). Reduced CB related to the expression of (a) Schneider's first rank symptoms of ideas-of-reference and (b) to negative symptoms like poor rapport and poor attention. CB was less evident in the older patients and those with an earlier illness-onset. In contrast to the similar LI test of selective attention, CB is found in patients with paranoid schizophrenia and its expression is not related closely to illness duration. This implies that the two tests reflect the activity of different underlying processes. We suggest that reduced CB on initial test-trials in nonparanoid schizophrenia reflects the unusual persistence of controlled information processing strategies that would normally become automatic during conditioning. In contrast, continued CB during testing reflects an unusual persistence of automatic processing strategies.

  20. Finite element code development for modeling detonation of HMX composites

    Science.gov (United States)

    Duran, Adam V.; Sundararaghavan, Veera

    2017-01-01

    In this work, we present a hydrodynamics code for modeling shock and detonation waves in HMX. A stable efficient solution strategy based on a Taylor-Galerkin finite element (FE) discretization was developed to solve the reactive Euler equations. In our code, well calibrated equations of state for the solid unreacted material and gaseous reaction products have been implemented, along with a chemical reaction scheme and a mixing rule to define the properties of partially reacted states. A linear Gruneisen equation of state was employed for the unreacted HMX calibrated from experiments. The JWL form was used to model the EOS of gaseous reaction products. It is assumed that the unreacted explosive and reaction products are in both pressure and temperature equilibrium. The overall specific volume and internal energy was computed using the rule of mixtures. Arrhenius kinetics scheme was integrated to model the chemical reactions. A locally controlled dissipation was introduced that induces a non-oscillatory stabilized scheme for the shock front. The FE model was validated using analytical solutions for SOD shock and ZND strong detonation models. Benchmark problems are presented for geometries in which a single HMX crystal is subjected to a shock condition.

  1. Separation and characterisation of detonation nanodiamond by capillary zone electrophoresis.

    Science.gov (United States)

    Duffy, Emer; Mitev, Dimitar P; Nesterenko, Pavel N; Kazarian, Artaches A; Paull, Brett

    2014-07-01

    A new method for the characterisation of purified detonation nanodiamond (DND) using CZE has been developed. The influence of BGE conditions on electrophoretic mobility, peak shape and particle aggregation was investigated, with resultant observations supported by zeta potential approximations and particle size measurements. Sodium tetraborate (pH 9.3), Tris (pH 9.3) and sodium phosphate (pH 7) were used in studying the BGE concentration effect on a commercial source of chemically stabilised DND. The BGE concentration had a strong effect on the stability of DND in suspension. The formation of aggregates of various sizes was observed as BGE concentration increased. The effect of pH on the electromigration of DND was examined using sodium phosphate (pH 8 and 10). The CZE method was subsequently applied to four different DND samples, which had undergone different routes of purification following detonation synthesis. Each sample produced a unique electrophoretic peak or profile in sodium tetraborate buffer (pH 9.3), such that the actual separation of DND samples from different sources could be achieved.

  2. An Equilibrium-Based Model of Gas Reaction and Detonation

    Energy Technology Data Exchange (ETDEWEB)

    Trowbridge, L.D.

    2000-04-01

    During gaseous diffusion plant operations, conditions leading to the formation of flammable gas mixtures may occasionally arise. Currently, these could consist of the evaporative coolant CFC-114 and fluorinating agents such as F2 and ClF3. Replacement of CFC-114 with a non-ozone-depleting substitute is planned. Consequently, in the future, the substitute coolant must also be considered as a potential fuel in flammable gas mixtures. Two questions of practical interest arise: (1) can a particular mixture sustain and propagate a flame if ignited, and (2) what is the maximum pressure that can be generated by the burning (and possibly exploding) gas mixture, should it ignite? Experimental data on these systems, particularly for the newer coolant candidates, are limited. To assist in answering these questions, a mathematical model was developed to serve as a tool for predicting the potential detonation pressures and for estimating the composition limits of flammability for these systems based on empirical correlations between gas mixture thermodynamics and flammability for known systems. The present model uses the thermodynamic equilibrium to determine the reaction endpoint of a reactive gas mixture and uses detonation theory to estimate an upper bound to the pressure that could be generated upon ignition. The model described and documented in this report is an extended version of related models developed in 1992 and 1999.

  3. Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus

    Directory of Open Access Journals (Sweden)

    Fuminori Sakurai

    2016-01-01

    Full Text Available Circulating tumor cells (CTCs are promising biomarkers in several cancers, and thus methods and apparatuses for their detection and quantification in the blood have been actively pursued. A novel CTC detection system using a green fluorescence protein (GFP–expressing conditionally replicating adenovirus (Ad (rAd-GFP was recently developed; however, there is concern about the production of false-positive cells (GFP-positive normal blood cells when using rAd-GFP, particularly at high titers. In addition, CTCs lacking or expressing low levels of coxsackievirus–adenovirus receptor (CAR cannot be detected by rAd-GFP, because rAd-GFP is constructed based on Ad serotype 5, which recognizes CAR. In order to suppress the production of false-positive cells, sequences perfectly complementary to blood cell–specific microRNA, miR-142-3p, were incorporated into the 3′-untranslated region of the E1B and GFP genes. In addition, the fiber protein was replaced with that of Ad serotype 35, which recognizes human CD46, creating rAdF35-142T-GFP. rAdF35-142T-GFP efficiently labeled not only CAR-positive tumor cells but also CAR-negative tumor cells with GFP. The numbers of false-positive cells were dramatically lower for rAdF35-142T-GFP than for rAd-GFP. CTCs in the blood of cancer patients were detected by rAdF35-142T-GFP with a large reduction in false-positive cells.

  4. 条件复制型腺病毒的研究进展%Advance of research in conditionally replicating adenovirus

    Institute of Scientific and Technical Information of China (English)

    邬朝平

    2011-01-01

    条件复制型腺病毒(conditionally replicating adenovirus,CRAd)基因治疗肿瘤的研究主要集中于提高其靶向性、增强肿瘤杀伤特异性,以及降低毒性作用三个方面.在提高CRAd靶向性的研究中,早期策略主要集中在腺病毒早期复制必需基因Ela/Elb突变或缺失的调控以及肿瘤或组织特异性启动子对其转录的调控;近年来利用组织特异性microRNA对病毒早期复制必需基因的转录后调控以及病毒外壳蛋白修饰的转导调控已逐渐成为研究的热点.在提高CRAd的肿瘤杀伤方面,除删除病毒自身凋亡抑制基因与导入外源性治疗基因两种方法以外,改造外壳纤毛提高病毒对靶细胞的亲嗜性及构建靶向肿瘤干细胞的CRAd成为新的关注点.同时,随着对腺病毒结构认识的逐步加深,修饰其外壳六邻体蛋白及其他外壳蛋白以降低CRAd的肝嗜性与免疫原性也正成为降低CRAd毒性作用的研究热点.

  5. Thermal degradation of two liquid fuels and detonation tests for pulse detonation engine studies

    Science.gov (United States)

    Rocourt, X.; Gillard, P.; Sochet, I.; Piton, D.; Prigent, A.

    2007-02-01

    The use of liquid fuels such as kerosene is of interest for the pulse detonation engine (PDE). Within this context, the aim of this work, which is a preliminary study, was to show the feasibility to initiate a detonation in air with liquid-fuel pyrolysis products, using energies and dimensions of test facility similars to those of PDEs. Therefore, two liquids fuels have been compared, JP10, which is a synthesis fuel generally used in the field of missile applications, and decane, which is one of the major components of standard kerosenes (F-34, Jet A1, ...). The thermal degradation of these fuels was studied with two pyrolysis processes, a batch reactor and a flow reactor. The temperatures varied from 600°C to 1,000°C and residence times for the batch reactor and the flow reactor were, respectively, between 10 30 s and 0.1 2 s. Subsequently, the detonability of synthetic gaseous mixtures, which was a schematisation of the decomposition state after the pyrolysis process, has been studied. The detonability study, regarding nitrogen dilution and equivalence ratio, was investigated in a 50 mm-diameter, 2.5 m-long detonation tube. These dimensions are compatible with applications in the aircraft industry and, more particularly, in PDEs. Therefore, JP10 and decane were compared to choose the best candidate for liquid-fuel PDE studies.

  6. Heat of detonation, the cylinder test, and performance munitions

    Energy Technology Data Exchange (ETDEWEB)

    Akst, I.B.

    1989-01-01

    Heats of detonation of CHNO explosives correlate well with copper cylinder test expansion data. The detonation products/calorimetry data can be used to estimate performance in the cylinder test, in munitions, and for new molecules or mixtures of explosives before these are made. Confidence in the accuracy of the performance estimates is presently limited by large deviations of a few materials from the regression predictions; but these same deviations, as in the insensitive explosive DINGU and the low carbon systems, appear to be sources of information useful for detonation and explosives research. The performance correlations are functions more of the detonation products and thermochemical energy than they are of the familiar parameters of detonation pressure and velocity, and the predictions are closer to a regression line on average than are those provided by CJ calculations. The prediction computations are simple but the measurements (detonation calorimetry/products and cylinder experiments) are not. 17 refs., 5 tabs.

  7. Insensitive detonator apparatus for initiating large failure diameter explosives

    Science.gov (United States)

    Perry, III, William Leroy

    2015-07-28

    A munition according to a preferred embodiment can include a detonator system having a detonator that is selectively coupled to a microwave source that functions to selectively prime, activate, initiate, and/or sensitize an insensitive explosive material for detonation. The preferred detonator can include an explosive cavity having a barrier within which an insensitive explosive material is disposed and a waveguide coupled to the explosive cavity. The preferred system can further include a microwave source coupled to the waveguide such that microwaves enter the explosive cavity and impinge on the insensitive explosive material to sensitize the explosive material for detonation. In use the preferred embodiments permit the deployment and use of munitions that are maintained in an insensitive state until the actual time of use, thereby substantially preventing unauthorized or unintended detonation thereof.

  8. The Universal Role of Tubulence in the Propagation of Strong Shocks and Detonation Waves

    Science.gov (United States)

    Lee, John H.

    2001-06-01

    The passage of a strong shock wave usually results in irreversible physical and chemical changes in the medium. If the chemical reactions are sufficiently exothermic, the shock wave can be self-propagating, i.e., sustained by the chemical energy release via the expansion work of the reaction products. Although shocks and detonations can be globally stable and propagate at constant velocities (in the direction of motion), their structure may be highly unstable and exhibit large hydrodynamic fluctuations, i.e., turbulence. Recent investigations on plastic deformation of polycrystalline material behind shock waves have revealed particle velocity dispersion at the mesoscopic level, a result of vortical rotational motion similar to that of turbulent fluid flows at high Reynolds number.1 Strong ionizing shocks in noble gases2, as well as dissociating shock waves in carbon dioxide,3 also demonstrate a turbulent density fluctuation in the non-equilibrium shock transition zone. Perhaps the most thoroughly investigated unstable structure is that of detonation waves in gaseous explosives.4 Detonation waves in liquid explosives such as nitromethane also take on similar unstable structure as gaseous detonations.5 There are also indications that detonations in solid explosives have a similar unsteady structure under certain conditions. Thus, it appears that it is more of a rule than an exception that the structure of strong shocks and detonations are unstable and exhibit turbulent-like fluctuations as improved diagnostics now permit us to look more closely at the meso- and micro-levels. Increasing attention is now devoted to the understanding of the shock waves at the micro-scale level in recent years. This is motivated by the need to formulate physical and chemical models that contain the correct physics capable of describing quantitatively the shock transition process. It should be noted that, in spite of its unstable 3-D structure, the steady 1-D conservation laws (in the

  9. Major Effects in the Thermodynamics of Detonation Products: Phase Segregation versus Ionic Dissociation

    Energy Technology Data Exchange (ETDEWEB)

    Bastea, S; Fried, L E

    2010-03-09

    Water (H{sub 2}O) and nitrogen (N{sub 2}) are major detonation products of high explosives and it has long been conjectured that they may phase segregate at high enough temperatures and pressures to influence detonation properties of common explosives. We analyze the phase diagram of H{sub 2}O-N{sub 2} mixtures using a thermodynamic theory for polar-nonpolar mixtures and find that phase segregation is unlikely to occur above approximately 1600K. Therefore, H{sub 2}O-N{sub 2} immiscibility is not likely to be relevant for detonation predictions. We propose instead that the high pressure ionic dissociation of water plays an important role in detonation, and model it using a new ionic thermodynamics. We employ this model in chemical equilibrium calculations of standard high explosives, e.g. PETN, HMX and RDX, and find that it performs very well under a wide range of conditions. Thus, although it may require further development, it is likely that explicitly ionic thermodynamics will become a standard tool for explosives modeling.

  10. A novel method for the measurement of the von Neumann spike in detonating high explosives

    Energy Technology Data Exchange (ETDEWEB)

    Sollier, A., E-mail: arnaud.sollier@cea.fr [CEA, DAM, DIF, 91297 Arpajon (France); Bouyer, V.; Hébert, P.; Doucet, M. [CEA, DAM, Le Ripault, 37260 Monts (France)

    2016-06-28

    We present detonation wave profiles measured in T2 (97 wt. % TATB) and TX1 (52 wt. % TATB and 45 wt. % HMX) high explosives. The experiments consisted in initiating a detonation wave in a 15 mm diameter cylinder of explosive using an explosive wire detonator and an explosive booster. Free surface velocity wave profiles were measured at the explosive/air interface using a Photon Doppler Velocimetry system. We demonstrate that a comparison of these free surface wave profiles with those measured at explosive/window interfaces in similar conditions allows to bracket the von Neumann spike in a narrow range. For T2, our measurements show that the spike pressure lies between 35.9 and 40.1 GPa, whereas for TX1, it lies between 42.3 and 47.0 GPa. The numerical simulations performed in support to these measurements show that they can be used to calibrate reactive burn models and also to check the accuracy of the detonation products equation of state at low pressure.

  11. A Novel Oblique Detonation Structure and Its Stability

    Institute of Scientific and Technical Information of China (English)

    TENG Hong-Hui; ZHAO Wei; JIANG Zong-Lin

    2007-01-01

    Oblique detonation structures induced by the wedge in the supersonic combustible gas mixtures are simulated numerically. The results show that the stationary oblique detonation structures are influenced by the gas flow Mach number, and a novel critical oblique detonation structure, which is characterized by a more complicated wave system, appears in the low Mach number cases. By introducing the inflow disturbance, its nonstationary evolution process is illustrated and its stability is verified.

  12. Experimental Magnetohydrodynamic Energy Extraction from a Pulsed Detonation

    Science.gov (United States)

    2015-03-01

    specific heat capacity, that would result in a 24% loss in energy for ionization. Second, the water and aqueous NaCl were added prior to detonation . This...Experimental Magnetohydrodynamic Energy Extraction from a Pulsed Detonation THESIS Kaz I. Teope, Captain, USAF AFIT-ENY-MS-15-M-224 DEPARTMENT OF THE... DETONATION THESIS Presented to the Faculty Department of Aeronautics and Astronautics Graduate School of Engineering and Management Air Force

  13. Generation of High Pressure and Temperature by Converging Detonation Waves

    Directory of Open Access Journals (Sweden)

    V. P. Singh

    1987-07-01

    Full Text Available Generation of high pressure and temperature has various applications in defence. Several techniques, viz flying plate method, collapsing of linear, convergence of detonation waves in solid explosives, have been established in this connection. In the present paper, converging detonation waves in solid explosives, where variable heat of detonation is being added to the front, is studied, by using Whitham's characteristics rule. Results are compared with those reported elsewhere.

  14. Generation of High Pressure and Temperature by Converging Detonation Waves

    OpenAIRE

    Singh, V. P.; Shukla, S K

    1987-01-01

    Generation of high pressure and temperature has various applications in defence. Several techniques, viz flying plate method, collapsing of linear, convergence of detonation waves in solid explosives, have been established in this connection. In the present paper, converging detonation waves in solid explosives, where variable heat of detonation is being added to the front, is studied, by using Whitham's characteristics rule. Results are compared with those reported elsewhere.

  15. Generation of high pressure and temperature by converging detonation waves

    Science.gov (United States)

    Singh, V. P.; Shukla, S. K.

    1987-07-01

    Generation of high pressure and temperature has various applications in defense. Several techniques, viz flying plate method, collapsing of linear, convergence of detonation waves in solid explosives, have been established in this connection. In this paper, converging detonation waves in solid explosives, where variable heat of detonation is being added to the front, are studied by using Whitham's characteristics rule. Results are compared with those reported elsewhere.

  16. Development of millisecond and internal delayed electric detonators in Hungary

    Energy Technology Data Exchange (ETDEWEB)

    Benedek, D.

    1986-01-01

    The stages of developing millisecond and internal delayed detonators are discussed. The problems of their practical introduction in Hungary as well as the economic background of their production are outlined. The present situation, i.e. production possibilities, application of different detonator types as well as the expected progress in the field of detonator production and use in mines endangered by fire-damp are dealt with.

  17. Detonation of Meta-stable Clusters

    Energy Technology Data Exchange (ETDEWEB)

    Kuhl, Allen; Kuhl, Allen L.; Fried, Laurence E.; Howard, W. Michael; Seizew, Michael R.; Bell, John B.; Beckner, Vincent; Grcar, Joseph F.

    2008-05-31

    We consider the energy accumulation in meta-stable clusters. This energy can be much larger than the typical chemical bond energy (~;;1 ev/atom). For example, polymeric nitrogen can accumulate 4 ev/atom in the N8 (fcc) structure, while helium can accumulate 9 ev/atom in the excited triplet state He2* . They release their energy by cluster fission: N8 -> 4N2 and He2* -> 2He. We study the locus of states in thermodynamic state space for the detonation of such meta-stable clusters. In particular, the equilibrium isentrope, starting at the Chapman-Jouguet state, and expanding down to 1 atmosphere was calculated with the Cheetah code. Large detonation pressures (3 and 16 Mbar), temperatures (12 and 34 kilo-K) and velocities (20 and 43 km/s) are a consequence of the large heats of detonation (6.6 and 50 kilo-cal/g) for nitrogen and helium clusters respectively. If such meta-stable clusters could be synthesized, they offer the potential for large increases in the energy density of materials.

  18. Molecular-dynamics investigation of the desensitization of detonable material

    Science.gov (United States)

    Rice, Betsy M.; Mattson, William; Trevino, Samuel F.

    1998-05-01

    A molecular-dynamics investigation of the effects of a diluent on the detonation of a model crystalline explosive is presented. The diluent, a heavy material that cannot exothermally react with any species of the system, is inserted into the crystalline explosive in two ways. The first series of simulations investigates the attenuation of the energy of a detonation wave in a pure explosive after it encounters a small layer of crystalline diluent that has been inserted into the lattice of the pure explosive. After the shock wave has traversed the diluent layer, it reenters the pure explosive. Unsupported detonation is not reestablished unless the energy of the detonation wave exceeds a threshold value. The second series of simulations investigates detonation of solid solutions of different concentrations of the explosive and diluent. For both types of simulations, the key to reestablishing or reaching unsupported detonation is the attainment of a critical number density behind the shock front. Once this critical density is reached, the explosive molecules make a transition to an atomic phase. This is the first step in the reaction mechanism that leads to the heat release that sustains the detonation. The reactive fragments formed from the atomization of the heteronuclear reactants subsequently combine with new partners, with homonuclear product formation exothermally favored. The results of detonation of the explosive-diluent crystals are consistent with those presented in an earlier study on detonation of pure explosive [B. M. Rice, W. Mattson, J. Grosh, and S. F. Trevino, Phys. Rev. E 53, 611 (1996)].

  19. Experimental study of the detonation of technical grade ammonium nitrate

    Science.gov (United States)

    Presles, Henri-Noël; Vidal, Pierre; Khasainov, Boris

    2009-11-01

    The detonation of technical grade ammonium nitrate at the density ρ=0.666 g/cm confined in PVC and steel tubes was experimentally studied. The results show that the detonation is self-sustained and steady in steel tubes with diameter as small as 12 mm. Critical detonation diameter lies between 8 and 12 mm in 2 mm thick steel tubes and between 55 and 81 mm in PVC tubes. These values testify a strong detonation sensitivity of this product. To cite this article: H.-N. Presles et al., C. R. Mecanique 337 (2009).

  20. Response Surface Optimization of Lead Azide for Explosive Detonators

    National Research Council Canada - National Science Library

    McCulloh, Ian; Massie, Darrell; Cordaro, Emily

    2006-01-01

    The Armament Research, Development and Engineering Center, Picatinny (ARDEC) has been tasked with developing a new chemical process to produce lead azide, the key explosive ingredient in detonators...

  1. A library of prompt detonation reaction zone data

    Energy Technology Data Exchange (ETDEWEB)

    Souers, P. C., LLNL

    1998-06-01

    Tables are given listing literature data that allows calculation of sonic reaction zones at or near steady-state for promptly detonating explosive cylinders. The data covers homogeneous, heterogeneous, composite, inorganic and binary explosives and allows comparison across the entire explosive field. Table 1 lists detonation front curvatures. Table 2 lists Size Effect data, i.e. the change of detonation velocity with cylinder radius. Table 3 lists failure radii and detonation velocities. Table 4 lists explosive compositions. A total of 51 references dating back into the 1950`s are given. Calculated reaction zones, radii of curvature and growth rate coefficients are listed.

  2. Estimating heats of detonation and detonation velocities of aromatic energetic compounds

    Energy Technology Data Exchange (ETDEWEB)

    Keshavarz, Mohammad Hossein [Department of Chemistry, Malek-ashtar University of Technology, Shahin-shahr, P. O. Box 83145/115 (Iran)

    2008-12-15

    A new method is introduced to predict reliable estimation of heats of detonation of aromatic energetic compounds. At first step, this procedure assumes that the heat of detonation of an explosive compound of composition C{sub a}H{sub b}N{sub c}O{sub d} can be approximated as the difference between the heat of formation of all H{sub 2}O-CO{sub 2} arbitrary (H{sub 2}O, CO{sub 2}, N{sub 2}) detonation products and that of the explosive, divided by the formula weight of the explosive. Overestimated results based on (H{sub 2}O-CO{sub 2} arbitrary) can be corrected in the next step. Predicted heats of detonation of pure energetic compounds with the product H{sub 2}O in the liquid state for 31 aromatic energetic compounds have a root mean square (rms) deviation of 2.08 and 0.34 kJ g{sup -1} from experiment for (H{sub 2}O-CO{sub 2} arbitrary) and new method, respectively. The new method also gives good results as compared to the second sets of decomposition products, which consider H{sub 2},N{sub 2}, H{sub 2}O,CO, and CO{sub 2} as major gaseous products. It is shown here how the predicted heats of detonation by the new method can be used to obtain reliable estimation of detonation velocity over a wide range of loading densities. (Abstract Copyright [2008], Wiley Periodicals, Inc.)

  3. Slag characterization and removal using pulse detonation for coal gasification. Quarterly research report, July 1--September 31, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Huque, Z.; Mei, D.; Biney, P.O.; Zhou, J.; Ali, M.R.

    1996-10-25

    Boiler slagging and fouling as a result of inorganic impurities in combustion gases being deposited on heat transfer tubes have caused severe problems in coal-fired power plant operation. These problems are fuel, system design, and operating condition dependent. Conventional slag and ash removal methods include the use of in situ blowing or jet-type devices such as air or steam soot blowers and water lances. Pulse detonation technology for the purpose of removing slag and fouling deposits in coal-fired utility power plant boilers offers great potential. The detonation wave technique based on high impact velocity with sufficient energy and thermal shock on the slag deposited on gas contact surfaces offers a convenient, inexpensive, yet efficient and effective way to supplement existing slag removal methods. These detonation waves have been demonstrated experimentally to have exceptionally high shearing capability important to the task of removing slag and fouling deposits. Several tests have been performed with single shot detonation wave at University of Texas at Arlington to remove the slag deposit. To hold the slag deposit samples at the exit of detonation tube, two types of fixture was designed and fabricated. They are axial arrangement and triangular arrangement. The slag deposits from the utility boilers have been used to prepare the slag samples for the test. The experimental results show that the single shot detonation wave is capable of removing the entire slag (types of slag deposited on economizer, and air-heater, i.e., relatively softer slags) and 30% of the reheater slag (which is harder) even at a distance of 6 in. from the exit of a detonation engine tube. Wave strength and slag orientation also have different effects on the chipping off of the slag. The annual report discusses about the results obtained in effectively removing the slag.

  4. Spent nuclear fuel project detonation phenomena of hydrogen/oxygen in spent fuel containers

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, T.D.

    1996-09-30

    Movement of Spent N Reactor fuels from the Hanford K Basins near the Columbia River to Dry interim storage facility on the Hanford plateau will require repackaging the fuel in the basins into multi-canister overpacks (MCOs), drying of the fuel, transporting the contained fuel, hot conditioning, and finally interim storage. Each of these functions will be accomplished while the fuel is contained in the MCOs by several mechanisms. The principal source of hydrogenand oxygen within the MCOs is residual water from the vacuum drying and hot conditioning operations. This document assesses the detonation phenomena of hydrogen and oxygen in the spent fuel containers. Several process scenarios have been identified that could generate detonation pressures that exceed the nominal 10 atmosphere design limit ofthe MCOS. Only 42 grams of radiolized water are required to establish this condition.

  5. Low-cost optoelectronic devices to measure velocity of detonation

    Science.gov (United States)

    Chan, Edwin M.; Lee, Vivian; Mickan, Samuel P.; Davies, Phil J.

    2005-02-01

    Velocity of Detonation (VoD) is an important measured characteristic parameter of explosive materials. When new explosives are developed, their VoD must be determined. Devices used to measure VoD are always destroyed in the process, however replacing these devices represents a considerable cost in the characterisation of new explosives. This paper reports the design and performance of three low-cost implementations of a point-to-point VoD measurement system, two using optical fibre and a third using piezoelectric polymers (PolyVinyliDine Flouride, PVDF). The devices were designed for short charges used under controlled laboratory conditions and were tested using the common explosive 'Composition B'. These new devices are a fraction of the cost of currently available VoD sensors and show promise in achieving comparable accuracy. Their future development will dramatically reduce the cost of testing and aid the characterisation of new explosives.

  6. Discrete approximations of detonation flows with structured detonation reaction zones by discontinuous front models: A program burn algorithm based on detonation shock dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Bdzil, J.B. [Los Alamos National Lab., NM (United States); Jackson, T.L. [Univ. of Illinois, Urbana, IL (United States). Center for Simulation of Advanced Rockets; Stewart, D.S. [Univ. of Illinois, Urbana, IL (United States). Theoretical and Applied Mechanics

    1999-02-02

    In the design of explosive systems the generic problem that one must consider is the propagation of a well-developed detonation wave sweeping through an explosive charge with a complex shape. At a given instant of time the lead detonation shock is a surface that occupies a region of the explosive and has a dimension that is characteristic of the explosive device, typically on the scale of meters. The detonation shock is powered by a detonation reaction zone, sitting immediately behind the shock, which is on the scale of 1 millimeter or less. Thus, the ratio of the reaction zone thickness to the device dimension is of the order of 1/1,000 or less. This scale disparity can lead to great difficulties in computing three-dimensional detonation dynamics. An attack on the dilemma for the computation of detonation systems has lead to the invention of sub-scale models for a propagating detonation front that they refer to herein as program burn models. The program burn model seeks not to resolve the fine scale of the reaction zone in the sense of a DNS simulation. The goal of a program burn simulation is to resolve the hydrodynamics in the inert product gases on a grid much coarser than that required to resolve a physical reaction zone. The authors first show that traditional program burn algorithms for detonation hydrocodes used for explosive design are inconsistent and yield incorrect shock dynamic behavior. To overcome these inconsistencies, they are developing a new class of program burn models based on detonation shock dynamic (DSD) theory. It is hoped that this new class will yield a consistent and robust algorithm which reflects the correct shock dynamic behavior.

  7. Hydrodynamical simulation of detonations in superbursts. I. The hydrodynamical algorithm and some preliminary one-dimensional results

    CERN Document Server

    Noel, C; Papalexandris, M V; Deledicque, V; Messoudi, A El

    2007-01-01

    Aims. This work presents a new hydrodynamical algorithm to study astrophysical detonations. A prime motivation of this development is the description of a carbon detonation in conditions relevant to superbursts, which are thought to result from the propagation of a detonation front around the surface of a neutron star in the carbon layer underlying the atmosphere. Methods. The algorithm we have developed is a finite-volume method inspired by the original MUSCL scheme of van Leer (1979). The algorithm is of second-order in the smooth part of the flow and avoids dimensional splitting. It is applied to some test cases, and the time-dependent results are compared to the corresponding steady state solution. Results. Our algorithm proves to be robust to test cases, and is considered to be reliably applicable to astrophysical detonations. The preliminary one-dimensional calculations we have performed demonstrate that the carbon detonation at the surface of a neutron star is a multiscale phenomenon. The length scale ...

  8. Predicting polarization signatures for double-detonation and delayed-detonation models of Type Ia supernovae

    CERN Document Server

    Bulla, M; Kromer, M; Seitenzahl, I R; Fink, M; Ciaraldi-Schoolmann, F; Roepke, F K; Hillebrandt, W; Pakmor, R; Ruiter, A J; Taubenberger, S

    2016-01-01

    Calculations of synthetic spectropolarimetry are one means to test multi-dimensional explosion models for Type Ia supernovae. In a recent paper, we demonstrated that the violent merger of a 1.1 and 0.9 M$_{\\odot}$ white dwarf binary system is too asymmetric to explain the low polarization levels commonly observed in normal Type Ia supernovae. Here, we present polarization simulations for two alternative scenarios: the sub-Chandrasekhar mass double-detonation and the Chandrasekhar mass delayed-detonation model. Specifically, we study a two-dimensional double-detonation model and a three-dimensional delayed-detonation model, and calculate polarization spectra for multiple observer orientations in both cases. We find modest polarization levels ($<$ 1 per cent) for both explosion models. Polarization in the continuum peaks at $\\sim$ 0.1$-$0.3 per cent and decreases after maximum light, in excellent agreement with spectropolarimetric data of normal Type Ia supernovae. Higher degrees of polarization are found ac...

  9. Investigation on Novel Methods to Increase Specific Thrust in Pulse Detonation Engines via Imploding Detonations

    Science.gov (United States)

    2009-12-01

    to-Detonation Transition, Specific Thrust 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT Unclassified 18. SECURITY CLASSIFICATION OF THIS...hydrocarbon fuel-air mixtures such as acetylene -air, ethylene-air, propane-air and even JP10-air mixtures based on the required length of the induction zone

  10. Three dimensional hemispherical test development to evaluate detonation wave breakout

    Science.gov (United States)

    Francois, E. G.; Morris, J. S.; Lieber, M.

    2014-05-01

    The Onionskin test has been the standard test to evaluate detonation wave breakout over a hemispherical surface for decades. It has been an effective test used in a variety of applications to qualify main charge materials, evaluate different boosters, and compare different detonators. It is not without its shortfalls however. It only images a small portion of the explosive and requires very precise alignment and camera requirements to make sense of the results. Asymmetry in explosive behavior cannot be pinpointed or evaluated effectively. We have developed a new diagnostic using fiber optics covering the surface of the explosive to yield a 3D representation of the detonation wave behavior. Precise timing mapping of the detonation over the hemispherical surface is generated which can be converted to detonation wave breakout behavior using Huygens' wave reconstruction. This report will include the results of a recent suite of tests on PBX 9501, and discussion of how the test was developed for this explosive and contrasting previous work on PBX 9502. The results of these tests will describe the effects on detonation wave breakout symmetry when Sylgard 184 is placed between the detonator and booster. The effects on symmetry and timing when the Sylgard gap thickness is increased and the detonator is canted will be shown.

  11. Half-Cell Law of Regular Cellular Detonations

    Institute of Scientific and Technical Information of China (English)

    WANG Chun; JIANG Zong-Lin; GAO Yun-Liang

    2008-01-01

    Numerical simulations illustrate the half-cell law of regular cellular detonations propagating in confined space,i.e., the number of cells always maintains an integral multiple of half cell. The cells adapt themselves larger or smaller to the size of the unconfined space by maintaining the cell scale larger or smaller than the original cells of detonation.

  12. Brief detonating characterization of lithanol; Caracterisation detonique succinte du lithanol

    Energy Technology Data Exchange (ETDEWEB)

    Morvan, J.; Courchinoux, R.; Darnez, Ch. [CEA Cesta, Centre d`Etudes Scientifiques et Techniques d`Aquitaine, 33 - Le Barp (France)

    1996-12-31

    Lithanol is a stoichiometric composition of tri-hydrated lithium perchlorate and aluminium. The underwater detonation of this explosive leads to the formation of a gaseous bubble essentially made of water vapor. In this paper, a brief detonating characterization of lithanol is presented using plates projection and cylinder raising up experiments. (J.S.) 5 refs.

  13. Detonation Diffraction in a Multi-Step Channel

    Science.gov (United States)

    2010-12-01

    section during a detonation. Shadowgraph setup utilizes an Ion Laser Technology Model 55001 Argon Ion laser emitting 750 mW beam at 488 nm passing...Rarefaction fan penetrating propagating a toward detonation axis (From [8... Solenoid Switches (lower section) (From [23]). ........ 39  Figure 29.  Sample Labview control panel

  14. Nano-scale spinning detonation in condensed phase energetic materials

    Science.gov (United States)

    Zhakhovsky, Vasily; Budzevich, Mikalai; Landerville, Aaron; White, Carter; Oleynik, Ivan

    2013-06-01

    Single- and multi-headed spinning detonation waves are observed in molecular dynamics simulations of a condensed phase detonation of an energetic material (EM) confined in round tubes of different radii. The EM is modeled using a modified AB Reactive Empirical Bond Order potential. The thermochemistry and reactive equation of state are varied by adjusting the barrier height for the exothermic reaction AB +B --> A +BB. This allows us to study the evolution of the detonation-wave structure as a function of physico-chemical properties of the AB explosive. The detonation wave is found to exhibit a pulsating planar front in a tube of 8 nm radius, which later collapses due to the development of longitudinal perturbations. Upon increase of the tube's radius to 16 nm, the detonation wave structure is stabilized through the development of a single-headed spinning detonation. The spinning detonation displays a four-wave configuration, including incident, oblique, transverse, and contact shock waves. The contact shock generated by a contact discontinuity is observed for the first time in our MD simulations. A multi-headed turbulent-like detonation structure develops within tubes of larger radii, and exhibit features similar to those observed in gases.

  15. 33 CFR 154.820 - Fire, explosion, and detonation protection.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Fire, explosion, and detonation protection. 154.820 Section 154.820 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... Systems § 154.820 Fire, explosion, and detonation protection. (a) A vapor control system with a...

  16. Direct Monte Carlo simulation of the chemical equilibrium composition of detonation products

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, M.S.

    1993-06-01

    A new Monte Carlo simulation method has been developed by the author which gives the equilibrium chemical composition of a molecular fluid directly. The usual NPT ensemble (isothermal-isobaric) is implemented with N being the number of atoms instead of molecules. Changes in chemical composition are treated as correlated spatial moves of atoms. Given the interaction potentials between molecular products, ``exact`` EOS points including the equilibrium chemical composition can be determined from the simulations. This method is applied to detonation products at conditions in the region near the Chapman- Jouget state. For the example of NO, it is shown that the CJ detonation velocity can be determined to a few meters per second. A rather small change in cross potentials is shown to shift the chemical equilibrium and the CJ conditions significantly.

  17. Laser High-Cycle Thermal Fatigue of Pulse Detonation Engine Combustor Materials Tested

    Science.gov (United States)

    Zhu, Dong-Ming; Fox, Dennis S.; Miller, Robert A.

    2001-01-01

    Pulse detonation engines (PDE's) have received increasing attention for future aerospace propulsion applications. Because the PDE is designed for a high-frequency, intermittent detonation combustion process, extremely high gas temperatures and pressures can be realized under the nearly constant-volume combustion environment. The PDE's can potentially achieve higher thermodynamic cycle efficiency and thrust density in comparison to traditional constant-pressure combustion gas turbine engines (ref. 1). However, the development of these engines requires robust design of the engine components that must endure harsh detonation environments. In particular, the detonation combustor chamber, which is designed to sustain and confine the detonation combustion process, will experience high pressure and temperature pulses with very short durations (refs. 2 and 3). Therefore, it is of great importance to evaluate PDE combustor materials and components under simulated engine temperatures and stress conditions in the laboratory. In this study, a high-cycle thermal fatigue test rig was established at the NASA Glenn Research Center using a 1.5-kW CO2 laser. The high-power laser, operating in the pulsed mode, can be controlled at various pulse energy levels and waveform distributions. The enhanced laser pulses can be used to mimic the time-dependent temperature and pressure waves encountered in a pulsed detonation engine. Under the enhanced laser pulse condition, a maximum 7.5-kW peak power with a duration of approximately 0.1 to 0.2 msec (a spike) can be achieved, followed by a plateau region that has about one-fifth of the maximum power level with several milliseconds duration. The laser thermal fatigue rig has also been developed to adopt flat and rotating tubular specimen configurations for the simulated engine tests. More sophisticated laser optic systems can be used to simulate the spatial distributions of the temperature and shock waves in the engine. Pulse laser high

  18. Contribution to the study of propulsive performances of a pulsed detonation engine; Contribution a l'etude des performances d'un moteur a detonation pulsee

    Energy Technology Data Exchange (ETDEWEB)

    Daniau, E.

    2001-12-15

    The works carried out in this study aim at quantifying the propelling efficiency of a pulsed detonation engine (reciprocating jet engine) and to study its aerobic configuration. The study of the propelling efficiency (specific pulse, thrust) has been performed with the C{sub 2}H{sub 4} - O{sub 2} mixture, the use of the H{sub 2}-air mixture being restricted to the aerobic demonstrator. In a first step, an analytical and theoretical study based on previous results has permitted to establish an efficiency model for the ideal case of a filled-up cylindrical combustion chamber, closed at one end and opened at the other end to the ambient atmosphere P{sub a}. The departure from the ideal case has been tackled by diminishing the detonation pressure with respect to P{sub a}. In a second step, several experimental studies (performed on mono-cycle bench) have been carried out to evaluate the influence of i) the presence of air inlets, ii) the partial filling of the chamber, iii) the presence of nozzles, iv) the presence of obstacles close to the ejection section, on the real efficiencies accessible with this type of engine. Specific experimental methods have been implemented and validated (pressure measurement on thrust wall, strioscopy visualisation, pulse measurement by ballistic pendulum) for the obtention of the two main parameters controlling the efficiencies: the specific pulse and the cycle time, this last one determining the maximum possible mass flow rate of reactive mixture or the maximum operation frequency. The realization of a 'real conditions' multi-cycle test bench has permitted to validate some technical solutions (necessity to initiate the detonation of the main H{sub 2}-air mixture using a pre-detonation system based on the highly reacting C{sub 2}H{sub 4}-O{sub 2} mixture) and to observe some specific phenomena of the multi-cycle operation. (J.S.)

  19. Jaguar Procedures for Detonation Behavior of Explosives Containing Boron

    Science.gov (United States)

    Stiel, L. I.; Baker, E. L.; Capellos, C.

    2009-12-01

    The Jaguar product library was expanded to include boron and boron containing products by analysis of Available Hugoniot and static volumetric data to obtain constants of the Murnaghan relationships for the components. Experimental melting points were also utilized to obtain the constants of the volumetric relationships for liquid boron and boron oxide. Detonation velocities for HMX—boron mixtures calculated with these relationships using Jaguar are in closer agreement with literature values at high initial densities for inert (unreacted) boron than with the completely reacted metal. These results indicate that the boron does not react near the detonation front or that boron mixtures exhibit eigenvalue detonation behavior (as shown by some aluminized explosives), with higher detonation velocities at the initial points. Analyses of calorimetric measurements for RDX—boron mixtures indicate that at high boron contents the formation of side products, including boron nitride and boron carbide, inhibits the detonation properties of the formulation.

  20. Measuring In-Situ Mdf Velocity Of Detonation

    Science.gov (United States)

    Horine, Frank M.; James, Jr., Forrest B.

    2005-10-25

    A system for determining the velocity of detonation of a mild detonation fuse mounted on the surface of a device includes placing the device in a predetermined position with respect to an apparatus that carries a couple of sensors that sense the passage of a detonation wave at first and second spaced locations along the fuse. The sensors operate a timer and the time and distance between the locations is used to determine the velocity of detonation. The sensors are preferably electrical contacts that are held spaced from but close to the fuse such that expansion of the fuse caused by detonation causes the fuse to touch the contact, causing an electrical signal to actuate the timer.

  1. Numerical investigation on evolution of cylindrical cellular detonation

    Institute of Scientific and Technical Information of China (English)

    WANG Chun; JIANG Zong-lin; HU Zong-min; HAN Gui-lai

    2008-01-01

    Cylindrical cellular detonation is numerically investigated by solving twodimensional reactive Euler equations with a finite volume method on a two-dimensional self-adaptive unstructured mesh.The one-step reversible chemical reaction model is applied to simplify the control parameters of chemical reaction.Numerical results demonstrate the evolution of cellular cell splitting of cylindrical cellular detonation explored in experimentas.Split of cellular structures shows different features in the near-field and far-field from the initiation zone.Variation of the local curvature is a key factor in the behavior of cell split of cylindrical cellular detonation in propagation.Numerical results show that split of cellular structures comes from the self-organization of transverse waves corresponding to the development of small disturbances along the detonation front related to detonation instability.

  2. Progress of continuously rotating detonation engines

    Institute of Scientific and Technical Information of China (English)

    Zhou Rui; Wu Dan; Wang Jianping

    2016-01-01

    Continuously rotating detonation engine (CRDE) is a focus for concern in the field of aerospace propulsion. It has several advantages, including one-initiation, high thermal efficiency and simple structure. Due to these characteristics, it is expected to bring revolutionary advance-ments to aviation and aerospace propulsion systems and now has drawn much attention throughout the world. In this paper, an overview of the development of CRDE is given from several aspects:basic concepts, applications, experimental studies, numerical simulations, and so on. Representative results and outstanding contributions are summarized and the unresolved issues for further engi-neering applications of CRDE are provided.

  3. Progress of continuously rotating detonation engines

    Directory of Open Access Journals (Sweden)

    Zhou Rui

    2016-02-01

    Full Text Available Continuously rotating detonation engine (CRDE is a focus for concern in the field of aerospace propulsion. It has several advantages, including one-initiation, high thermal efficiency and simple structure. Due to these characteristics, it is expected to bring revolutionary advancements to aviation and aerospace propulsion systems and now has drawn much attention throughout the world. In this paper, an overview of the development of CRDE is given from several aspects: basic concepts, applications, experimental studies, numerical simulations, and so on. Representative results and outstanding contributions are summarized and the unresolved issues for further engineering applications of CRDE are provided.

  4. Semiautomatic MDF deburring tool. [Mild detonating fuse

    Energy Technology Data Exchange (ETDEWEB)

    Simonton, W.L.

    1976-03-31

    A device for semiautomatically deburring the ends of lengths of MDF (mild detonating fuse) was developed by the Automation Development group at Mound Laboratory. The device performs the deburring function by cutting a 0.002 in. x 0.002 in. chamfer on the MDF with small rotating blades. This air-operated, semiautomatic device provides improvement over the manual method of removing burrs by reduction in time and operator strain. A time study is underway to determine the time saved which is expected to be about 75 percent.

  5. Shock-to-Detonation Transition simulations

    Energy Technology Data Exchange (ETDEWEB)

    Menikoff, Ralph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-07-14

    Shock-to-detonation transition (SDT) experiments with embedded velocity gauges provide data that can be used for both calibration and validation of high explosive (HE) burn models. Typically, a series of experiments is performed for each HE in which the initial shock pressure is varied. Here we describe a methodology for automating a series of SDT simulations and comparing numerical tracer particle velocities with the experimental gauge data. Illustrative examples are shown for PBX 9502 using the HE models implemented in the xRage ASC code at LANL.

  6. Archaeal DNA replication.

    Science.gov (United States)

    Kelman, Lori M; Kelman, Zvi

    2014-01-01

    DNA replication is essential for all life forms. Although the process is fundamentally conserved in the three domains of life, bioinformatic, biochemical, structural, and genetic studies have demonstrated that the process and the proteins involved in archaeal DNA replication are more similar to those in eukaryal DNA replication than in bacterial DNA replication, but have some archaeal-specific features. The archaeal replication system, however, is not monolithic, and there are some differences in the replication process between different species. In this review, the current knowledge of the mechanisms governing DNA replication in Archaea is summarized. The general features of the replication process as well as some of the differences are discussed.

  7. Evaluation of detonation energy from EXPLO5 computer code results

    Energy Technology Data Exchange (ETDEWEB)

    Suceska, M. [Brodarski Institute, Zagreb (Croatia). Marine Research and Special Technologies

    1999-10-01

    The detonation energies of several high explosives are evaluated from the results of chemical-equilibrium computer code named EXPLO5. Two methods of the evaluation of detonation energy are applied: (a) Direct evaluation from the internal energy of detonation products at the CJ point and the energy of shock compression of the detonation products, i.e. by equating the detonation energy and the heat of detonation, and (b) evaluation from the expansion isentrope of detonation products, applying the JWL model. These energies are compared to the energies computed from cylinder test derived JWL coefficients. It is found out that the detonation energies obtained directly from the energy of detonation products at the CJ point are uniformly to high (0.9445{+-}0.577 kJ/cm{sup 3}) while the detonation energies evaluated from the expansion isentrope, are in a considerable agreement (0.2072{+-}0.396 kJ/cm{sup 3}) with the energies calculated from cylinder test derived JWL coefficients. (orig.) [German] Die Detonationsenergien verschiedener Hochleistungssprengstoffe werden bewertet aus den Ergebnissen des Computer Codes fuer chemische Gleichgewichte genannt EXPLO5. Zwei Methoden wurden angewendet: (a) Direkte Bewertung aus der inneren Energie der Detonationsprodukte am CJ-Punkt und aus der Energie der Stosskompression der Detonationsprodukte, d.h. durch Gleichsetzung von Detonationsenergie und Detonationswaerme, (b) Auswertung durch die Expansions-Isentrope der Detonationsprodukte unter Anwendung des JWL-Modells. Diese Energien werden verglichen mit den berechneten Energien mit aus dem Zylindertest abgeleiteten JWL-Koeffizienten. Es wird gefunden, dass die Detonationsenergien, die direkt aus der Energie der Detonationsprodukte beim CJ-Punkt erhalten wurden, einheitlich zu hoch sind (0,9445{+-}0,577 kJ/cm{sup 3}), waehrend die aus der Expansions-Isentrope erhaltenen in guter Uebereinstimmung sind (0,2072{+-}0,396 kJ/cm{sup 3}) mit den berechneten Energien mit aus dem Zylindertest

  8. Axisymmetric Numerical Modeling of Pulse Detonation Rocket Engines

    Science.gov (United States)

    Morris, Christopher I.

    2005-01-01

    Pulse detonation rocket engines (PDREs) have generated research interest in recent years as a chemical propulsion system potentially offering improved performance and reduced complexity compared to conventional rocket engines. The detonative mode of combustion employed by these devices offers a thermodynamic advantage over the constant-pressure deflagrative combustion mode used in conventional rocket engines and gas turbines. However, while this theoretical advantage has spurred considerable interest in building PDRE devices, the unsteady blowdown process intrinsic to the PDRE has made realistic estimates of the actual propulsive performance problematic. The recent review article by Kailasanath highlights some of the progress that has been made in comparing the available experimental measurements with analytical and numerical models. In recent work by the author, a quasi-one-dimensional, finite rate chemistry CFD model was utilized to study the gasdynamics and performance characteristics of PDREs over a range of blowdown pressure ratios from 1-1000. Models of this type are computationally inexpensive, and enable first-order parametric studies of the effect of several nozzle and extension geometries on PDRE performance over a wide range of conditions. However, the quasi-one-dimensional approach is limited in that it cannot properly capture the multidimensional blast wave and flow expansion downstream of the PDRE, nor can it resolve nozzle flow separation if present. Moreover, the previous work was limited to single-pulse calculations. In this paper, an axisymmetric finite rate chemistry model is described and utilized to study these issues in greater detail. Example Mach number contour plots showing the multidimensional blast wave and nozzle exhaust plume are shown. The performance results are compared with the quasi-one-dimensional results from the previous paper. Both Euler and Navier-Stokes solutions are calculated in order to determine the effect of viscous

  9. Physicochemical model of detonation synthesis of nanoparticles from metal carboxylates

    Science.gov (United States)

    Tolochko, B. P.; Chernyshev, A. P.; Ten, K. A.; Pruuel, E. R.; Zhogin, I. L.; Zubkov, P. I.; Lyakhov, N. Z.; Luk'yanchikov, L. A.; Sheromov, M. A.

    2008-02-01

    We have shown previously that when metal carboxylates are subjected to a shock-wave action, diamond nanoparticles and nanoparticles of metals (Ag, Bi, Co, Fe, Pb) are formed and their characteristic size is about 30-200 Å. The metal nanoparticles formed are covered by an amorphous-carbon layer up to 20 Å thick. In this work we put forward a physicochemical model of the formation of diamond and metal nanoparticles from metal carboxylates upon shock-wave action. The energy released upon detonation inside the precursor is lower than in regions not occupied by the stearates. The characteristic time of temperature equalization has been estimated to be on the order of ˜10-3 s, which is greater by a factor of ˜103 than the characteristic reaction time. Due to the adiabatic nature of the processes occurring, the typical temperature of a "particle" will be lower than the temperature of the surrounding medium. In the framework of the model suggested, it has been assumed that the growth of metal clusters should occur by the diffusion mechanism; i.e., the "building material" is supplied through diffusion. The calculation using our previous experimental data on the reaction time and average size of metal particles has shown that the diffusion properties of the medium in which the metal nanoparticles are formed are close to those of the liquid state of the substance. The temperature and pressure under detonation conditions markedly exceed the analogous parameters characteristic of experiments on the thermodestruction of metal carboxylates. The small time of existence of the reaction mixture is compensated by the high mobility and concentration of reagents.

  10. Detonation discrimination and feature saliency using a near-infrared focal plane array and a visible CCD camera

    Science.gov (United States)

    Dills, Anthony N.; Gustafson, Steven C.; Perram, Glen P.

    2005-05-01

    This research investigates the classification of battlespace detonations, specifically the determination of munitions type and size using temporal and spectral features from near-infrared (NIR) and visible wavelength imagers. Key features from the time dependence of fireball size are identified for discriminating various types and sizes of detonation flashes. The five classes include three weights of trinitrotoluene (TNT) and two weights of an enhanced mixture, all of which are uncased and detonated with 10% C-4. Using Fisher linear discriminant techniques, these features are projected onto a line such that the projected points are maximally clustered for the different classes of detonations. Bayesian decision boundaries for classification are then established on class-conditional probability densities and are tested using independent test data. Feature saliency and stability are determined by selecting those features that best discriminate while requiring low variations in class-conditional probability densities and high performance in independent testing. Given similar conditions, the most important and stable feature is the time to the maximum fireball area in the near-infrared wavelength band (0.6 to 1.7 microns). This feature correctly discriminates between TNT and ENE about 90% of the time, whether weight is known or not. The associated class-conditional probability densities separate the two classes with a Fisher ratio of 2.9+/-0.3 and an area under the receiver operating characteristic, AROC, of 0.992. Also, tmp achieves approximately 54% success rate at discerning both weight and type.

  11. Thermonuclear detonations ensuing white dwarf mergers

    CERN Document Server

    Dan, Marius; Brüggen, Marcus; Ramirez-Ruiz, Enrico; Rosswog, Stephan

    2015-01-01

    The merger of two white dwarfs (WDs) has for many years not been considered as the favoured model for the progenitor system of type Ia supernovae (SNe Ia). But recent years have seen a change of opinion as a number of studies, both observational and theoretical, have concluded that they should contribute significantly to the observed type Ia supernova rate. In this paper, we study the ignition and propagation of detonation through post-merger remnants and we follow the resulting nucleosynthesis up to the point where a homologous expansion is reached. In our study we cover the entire range of WD masses and compositions. For the emergence of a detonation we study several setups, guided by both merger remnants from our own simulations and by results taken from the literature. We carefully compare the nucleosynthetic yields of successful explosions with SN Ia observations. Only three of our models are consistent with all the imposed constraints and potentially lead to a standard type Ia event. The first one, a $0...

  12. Sustained inhibition of HIV-1 replication by conditional expression of the E. coli-derived endoribonuclease MazF in CD4+ T cells.

    Science.gov (United States)

    Okamoto, Mika; Chono, Hideto; Kawano, Yasuhiro; Saito, Naoki; Tsuda, Hiroshi; Inoue, Koichi; Kato, Ikunoshin; Mineno, Junichi; Baba, Masanori

    2013-04-01

    Gene therapy using a Tat-dependent expression system of MazF, an ACA nucleotide sequence-specific endoribonuclease derived from Escherichia coli, in a retroviral vector appears to be an alternative approach to the treatment of human immunodeficiency virus type 1 (HIV-1) infection. MazF can cleave HIV-1 RNA, since it has more than 240 ACA sequences. Significant inhibition of viral replication, irrespective of HIV-1 strains, was observed in CD4(+) T cells that had been transduced with the MazF-expressing retroviral vector (MazF-T cells). The growth and viability of MazF-T cells were not affected by HIV-1 infection. Interestingly, the infectivity of HIV-1 produced from MazF-T cells was found to be lower than that from control CD4(+) T cells. A long-term culture experiment with HIV-1-infected cells revealed that viral replication was always lower in MazF-T cells than in CD4(+) T cells transduced with or without a control vector for more than 200 days. MazF was expressed and mainly localized in the cytoplasm of the infected cells. Unlike in CD4(+) T cells, the expression level of Tat gradually decreased rather than increased in MazF-T cells after HIV-1 infection. As a consequence, the expression level of MazF appeared to be well regulated and sustained during HIV-1 infection in MazF-T cells. Furthermore, the levels of cellular mRNA were not affected by HIV-1 infection. Thus, the Tat-dependent MazF expression system has great potential for inhibition of HIV-1 replication in vivo without apparent toxicity and may be able to avoid the emergence of resistant strains.

  13. Simulations of the Gravitationally Confined Detonation Model of Type Ia Supernovae for Multiple Ignition Points

    Science.gov (United States)

    Jordan, G. C.; Meakin, C. A.; Hearn, N.; Fisher, R. T.; Townsley, D. M.; Lamb, D. Q.; Truran, J. W.

    2009-04-01

    In this paper we present 3D simulations of the gravitationally confined detonation (GCD) model of Type Ia Supernovae with multiple ignition points as initial conditions. These simulations release more energy during the deflagration (subsonic nuclear combustion) phase than previous GCD simulations initiated with a single ignition point. Due to the increased amount of fuel consumed during the deflagration, the star undergoes a more energetic pulsation which at the time of detonation increases the amount of low-density, intermediate-mass-producing material and decreases the amount of high-density, NSE-producing material. This results in the production of approximately 0.7 M⊙ of 56Ni in the explosion, an amount that observations indicate is produced in Type Ia supernovae having typical luminosities.

  14. Comparison of Numerically Simulated and Experimentally Measured Performance of a Rotating Detonation Engine

    Science.gov (United States)

    Paxson, Daniel E.; Fotia, Matthew L.; Hoke, John; Schauer, Fred

    2015-01-01

    A quasi-two-dimensional, computational fluid dynamic (CFD) simulation of a rotating detonation engine (RDE) is described. The simulation operates in the detonation frame of reference and utilizes a relatively coarse grid such that only the essential primary flow field structure is captured. This construction and other simplifications yield rapidly converging, steady solutions. Viscous effects, and heat transfer effects are modeled using source terms. The effects of potential inlet flow reversals are modeled using boundary conditions. Results from the simulation are compared to measured data from an experimental RDE rig with a converging-diverging nozzle added. The comparison is favorable for the two operating points examined. The utility of the code as a performance optimization tool and a diagnostic tool are discussed.

  15. Neutrinos from Type Ia Supernovae I: The Deflagration-To-Detonation Transition Scenario

    CERN Document Server

    Wright, Warren P; Kneller, James P; Scholberg, Kate; Seitenzahl, Ivo R

    2016-01-01

    It has long been recognized that the neutrinos detected from the next core-collapse supernova in the Galaxy have the potential to reveal important information about the dynamics of the explosion and the nucleosynthesis conditions as well as allowing us to probe the properties of the neutrino itself. The neutrinos emitted from thermonuclear - Type Ia - supernovae also possess the same potential, although these supernovae are dimmer neutrino sources. For the first time, we calculate the time, energy, line of sight and neutrino-flavor-dependent features of the neutrino signal expected from a three-dimensional delayed-detonation explosion simulation, where a deflagration-to-detonation transition (DDT) triggers the complete disruption of a near-Chandrasekhar mass carbon-oxygen white dwarf. We also calculate the neutrino flavor evolution along eight lines of sight through the simulation as a function of time and energy using an exact 3-flavor transformation code. We identify a characteristic spectral peak at $\\sim ...

  16. Investigation on the propagation process of rotating detonation wave

    Science.gov (United States)

    Deng, Li; Ma, Hu; Xu, Can; Zhou, Changsheng; Liu, Xiao

    2017-10-01

    Effects of mass flow rate and equivalence ratio on the wave speed performance and instantaneous pressure characteristics of rotating detonation wave are investigated using hydrogen and air mixtures. The interaction between air and fuel manifolds and combustion chamber is also identified. The results show that the rotating detonation waves are able to adapt themselves to the changes of equivalence ratio during the run, the rotating detonation waves decayed gradually and then quenched after the shutdown of reactants supply. The wave speed performance is closely related to the mass flow rate and the pressure ratio of the fuel to air manifolds at different equivalence ratios. The blockage ratio of the air manifold increases with the increasing of the wave speed due to high-pressure detonation products, while increasing of the equivalence ratios will reduce the blockage ratio of the hydrogen manifold. Higher equivalence ratio can enhance the stabilization of the rotating detonation wave and lower equivalence ratio will lead to the large fluctuations of the lap time and instantaneous pressure magnitude. The overpressure of rotating detonation wave is determined by the combination of mass flow rate and equivalence ratio, which increases with the increasing of mass flow rate in the equivalence ratio ranges that the rotating detonation wave propagates stably. The secondary spike in the instantaneous pressure and ionization signals indicates that a shocked mixing zone exists near the fuel injection holes and the reflection of shock in the mixing zone induces the reaction.

  17. Optimum performance of explosives in a quasistatic detonation cycle

    Science.gov (United States)

    Baker, Ernest L.; Stiel, Leonard I.

    2017-01-01

    Analyses were conducted on the behavior of explosives in a quasistatic detonation cycle. This type of cycle has been proposed for the determination of the maximum work that can be performed by the explosive. The Jaguar thermochemical equilibrium program enabled the direct analyses of explosive performance at the various steps in the detonation cycle. In all cases the explosive is initially detonated to a point on the Hugoniot curve for the reaction products. The maximum useful work that can be obtained from the explosive is equal to the P-V work on the isentrope for expansion after detonation to atmospheric pressure, minus one-half the square of the particle velocity at the detonation point. This quantity is calculated form the internal energy of the explosive at the initial and final atmospheric temperatures. Cycle efficiencies (net work/ heat added) are also calculated with these procedures. For several explosives including TNT, RDX, and aluminized compositions, maximum work effects were established through the Jaguar calculations for Hugoniot points corresponding to C-J, overdriven, underdriven and constant volume detonations. Detonation to the C-J point is found to result in the maximum net work in all cases.

  18. Development of a chemical microthruster based on pulsed detonation

    Science.gov (United States)

    Wu, Ming-Hsun; Lu, Tsung-Hsun

    2012-10-01

    The development of a microthruster based on gaseous pulsed detonation is presented in this study. The feasibility of cyclic valveless pulsed detonation at frequencies over 100 Hz is first experimentally investigated in a microchannel with 1 mm × 0.6 mm rectangular cross-section. Highly reactive ethylene/oxygen mixtures are utilized to reduce the time and distance required for the reaction wave to run up to detonation in a smooth channel. High-speed visualizations have shown that the reaction waves reach detonative state through highly repeatable flame acceleration and deflagration-to-detonation transition processes in the channel. The validated concepts are implemented for the development of an integrated pulsed detonation microthruster. The microthruster was fabricated using low temperature co-fired ceramic tape technology. The volume of the reaction channel in the microthruster was 58 mm3. Spark electrodes and ion probes were embedded in the ceramic microthruster. The channel and via holes were fabricated using laser cutting techniques. Ion probe measurements showed that the reaction wave propagated at velocities larger than 2000 m s-1 before reaching the channel exit. The pulsed detonation microthruster has been successfully operated at frequencies as high as 200 Hz.

  19. Effect of fuel stratification on detonation wave propagation

    Science.gov (United States)

    Masselot, Damien; Fievet, Romain; Raman, Venkat

    2016-11-01

    Rotating detonation engines (RDEs) form a class of pressure-gain combustion systems of higher efficiency compared to conventional gas turbine engines. One of the key features of the design is the injection system, as reactants need to be continuously provided to the detonation wave to sustain its propagation speed. As inhomogeneities in the reactant mixture can perturb the detonation wave front, premixed fuel jet injectors might seem like the most stable solution. However, this introduces the risk of the detonation wave propagating through the injector, causing catastrophic failure. On the other hand, non-premixed fuel injection will tend to quench the detonation wave near the injectors, reducing the likelihood of such failure. Still, the effects of such non-premixing and flow inhomogeneities ahead of a detonation wave have yet to be fully understood and are the object of this study. A 3D channel filled with O2 diluted in an inert gas with circular H2 injectors is simulated as a detonation wave propagates through the system. The impact of key parameters such as injector spacing, injector size, mixture composition and time variations will be discussed. PhD Candidate.

  20. SLAG CHARACTERIZATION AND REMOVAL USING PULSE DETONATION TECHNOLOGY DURING COAL GASIFICATION

    Energy Technology Data Exchange (ETDEWEB)

    DR. DANIEL MEI; DR. JIANREN ZHOU; DR. PAUL O. BINEY; DR. ZIAUL HUQUE

    1998-07-30

    Pulse detonation technology for the purpose of removing slag and fouling deposits in coal-fired utility power plant boilers offers great potential. Conventional slag removal methods including soot blowers and water lances have great difficulties in removing slags especially from the down stream areas of utility power plant boilers. The detonation wave technique, based on high impact velocity with sufficient energy and thermal shock on the slag deposited on gas contact surfaces offers a convenient, inexpensive, yet efficient and effective way to supplement existing slag removal methods. A slight increase in the boiler efficiency, due to more effective ash/deposit removal and corresponding reduction in plant maintenance downtime and increased heat transfer efficiency, will save millions of dollars in operational costs. Reductions in toxic emissions will also be accomplished due to reduction in coal usage. Detonation waves have been demonstrated experimentally to have exceptionally high shearing capability, important to the task of removing slag and fouling deposits. The experimental results describe the parametric study of the input parameters in removing the different types of slag and operating condition. The experimental results show that both the single and multi shot detonation waves have high potential in effectively removing slag deposit from boiler heat transfer surfaces. The results obtained are encouraging and satisfactory. A good indication has also been obtained from the agreement with the preliminary computational fluid dynamics analysis that the wave impacts are more effective in removing slag deposits from tube bundles rather than single tube. This report presents results obtained in effectively removing three different types of slag (economizer, reheater, and air-heater) t a distance of up to 20 cm from the exit of the detonation tube. The experimental results show that the softer slags can be removed more easily. Also closer the slag to the exit of

  1. Oblique detonation waves stabilized in rectangular-cross-section bent tubes

    OpenAIRE

    2011-01-01

    Oblique detonation waves, which are generated by a fundamental detonation phenomenon occurring in bent tubes, may be applied to fuel combustion in high-efficiency engines such as a pulse detonation engine (PDE) and a rotating detonation engine (RDE). The present study has experimentally demonstrated that steady-state oblique detonation waves propagated stably through rectangular-cross-section bent tubes by visualizing these waves using a high-speed camera and the shadowgraph method. The obliq...

  2. Detonation Propagation in 180°Ribs of an Insensitive High Energy Explosive

    Institute of Scientific and Technical Information of China (English)

    S. N. Lubyatinsky; A. Yu. Garmashev; V. G. Israelyan; O. V. Kostitsin; B. G. Loboiko; V. A. Pashentsev; V. A. Sibilev; E. B. Smirnov; V. P. Filin

    2004-01-01

    @@ Steady detonation regimes, such as the detonation of explosive rate sticks, are of particular interest in studies of explosive reaction kinetics. If this is the case the detonation front shape as well as the fields of particle velocity, pressure etc. are steady in the system of coordinates linked to the detonation front. This facilitates the analysis of the experimental data obtained to verify or calibrate various detonation models.

  3. Predicting polarization signatures for double-detonation and delayed-detonation models of Type Ia supernovae

    Science.gov (United States)

    Bulla, M.; Sim, S. A.; Kromer, M.; Seitenzahl, I. R.; Fink, M.; Ciaraldi-Schoolmann, F.; Röpke, F. K.; Hillebrandt, W.; Pakmor, R.; Ruiter, A. J.; Taubenberger, S.

    2016-10-01

    Calculations of synthetic spectropolarimetry are one means to test multidimensional explosion models for Type Ia supernovae. In a recent paper, we demonstrated that the violent merger of a 1.1 and 0.9 M⊙ white dwarf binary system is too asymmetric to explain the low polarization levels commonly observed in normal Type Ia supernovae. Here, we present polarization simulations for two alternative scenarios: the sub-Chandrasekhar mass double-detonation and the Chandrasekhar mass delayed-detonation model. Specifically, we study a 2D double-detonation model and a 3D delayed-detonation model, and calculate polarization spectra for multiple observer orientations in both cases. We find modest polarization levels (<1 per cent) for both explosion models. Polarization in the continuum peaks at ˜0.1-0.3 per cent and decreases after maximum light, in excellent agreement with spectropolarimetric data of normal Type Ia supernovae. Higher degrees of polarization are found across individual spectral lines. In particular, the synthetic Si II λ6355 profiles are polarized at levels that match remarkably well the values observed in normal Type Ia supernovae, while the low degrees of polarization predicted across the O I λ7774 region are consistent with the non-detection of this feature in current data. We conclude that our models can reproduce many of the characteristics of both flux and polarization spectra for well-studied Type Ia supernovae, such as SN 2001el and SN 2012fr. However, the two models considered here cannot account for the unusually high level of polarization observed in extreme cases such as SN 2004dt.

  4. Geometry-specific scaling of detonation parameters from front curvature

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, Scott I [Los Alamos National Laboratory; Short, Mark [Los Alamos National Laboratory

    2011-01-20

    It has previously been asserted that classical detonation curvature theory predicts that the critical diameter and the diameter-effect curve of a cylindrical high-explosive charge should scale with twice the thickness of an analogous two-dimensional explosive slab. The varied agreement of experimental results with this expectation have led some to question the ability of curvature-based concepts to predict detonation propagation in non-ideal explosives. This study addresses such claims by showing that the expected scaling relationship (hereafter referred to d = 2w) is not consistent with curvature-based Detonation Shock Dynamics (DSD) theory.

  5. Detonation of the aluminized explosives with sodium azide

    Energy Technology Data Exchange (ETDEWEB)

    Maranda, A.; Nowaczewski, J.; Trzcinski, W. [Military University of Technology Kaliskiego, Warsaw (Poland)

    1996-12-31

    The velocity of detonation in the aluminized explosives containing sodium azide was measured. he experimental results were compared with those of calculation. Two different explosive components were used in the tests: RDX and ammonium nitrate. The contents of constituents of explosive mixture varied within a wide range. The X-ray analysis of the solid detonation products was also made. The results enable us to predict a behaviour of sodium azide and aluminium during detonation process of the explosive tested and to verify the possibility of reaction between aluminium and nitrogen during that process. (authors) 12 refs.

  6. Deflagration to Detonation Transition Behavior of Aluminized HMX

    Science.gov (United States)

    1979-06-04

    NSWC TR 79-119 tLN DEFLAG RATION TO DETONATION TRANSITION BEHAVIOR OF ALUMINIZED HMX BY DONNA PRICE A. R. CLAIRMONT, JR 0 RESEARCH AND TECHNOLOGY...Detonation of Solid Explosives," J. Chem. Soc., 4154, 1960. 3Bernecker, R. R. and Price , D., "Studies in the Transition from Deflagration to Detonation in...Laboratory TR 74-186. 4 NSWC TR 79-119 tube with heavy end closures. The column length of the 0.35 g of 25/75 B/ KNO3 ignitor is 6.3 mm; the length of

  7. Production of bioactive soluble interleukin-15 in complex with interleukin-15 receptor alpha from a conditionally-replicating oncolytic HSV-1.

    Directory of Open Access Journals (Sweden)

    David C Gaston

    Full Text Available Oncolytic type-1 herpes simplex viruses (oHSVs lacking the γ134.5 neurovirulence gene are being evaluated for treatment of a variety of malignancies. oHSVs replicate within and directly kill permissive cancer cells. To augment their anti-tumor activity, oHSVs have been engineered to express immunostimulatory molecules, including cytokines, to elicit tumor-specific immune responses. Interleukin-15 (IL-15 holds potential as an immunotherapeutic cytokine because it has been demonstrated to promote both natural killer (NK cell-mediated and CD8(+ T cell-mediated cytotoxicity against cancer cells. The purpose of these studies was to engineer an oHSV producing bioactive IL-15. Two oHSVs were constructed encoding murine (mIL-15 alone (J100 or with the mIL-15 receptor α (mIL-15Rα, J100D to determine whether co-expression of these proteins is required for production of bioactive mIL-15 from oHSV. The following were demonstrated: i both oHSVs retain replication competence and cytotoxicity in permissive tumor cell lines. ii Enhanced production of mIL-15 was detected in cell lysates of neuro-2a cells following J100D infection as compared to J100 infection, suggesting that mIL-15Rα improved mIL-15 production. iii Soluble mIL-15 in complex with mIL-15Rα was detected in supernates from J100D-infected, but not J100-infected, neuro-2a, GL261, and CT-2A cells. These cell lines vary in permissiveness to oHSV replication and cytotoxicity, demonstrating soluble mIL-15/IL-15Rα complex production from J100D was independent of direct oHSV effects. iv The soluble mIL-15/IL-15Rα complex produced by J100D was bioactive, stimulating NK cells to proliferate and reduce the viability of syngeneic GL261 and CT-2A cells. v J100 and J100D were aneurovirulent inasmuch as no neuropathologic effects were documented following direct inoculation into brains of CBA/J mice at up to 1x10(7 plaque forming units. The production of mIL-15/mIL-15Rα from multiple tumor lines, as well

  8. Surface micro topography replication in injection moulding

    DEFF Research Database (Denmark)

    Arlø, Uffe Rolf

    of the mechanisms controlling topography replication. Surface micro topography replication in injection moulding depends on the main elements of  Process conditions  Plastic material  Mould topography In this work, the process conditions is the main factor considered, but the impact of plastic material...

  9. Mutational library analysis of selected amino acids in the receptor binding domain of envelope of Akv murine leukemia virus by conditionally replication competent bicistronic vectors

    DEFF Research Database (Denmark)

    Bahrami, Shervin; Pedersen, Finn Skou; Duch, Mogens R.

    2003-01-01

    envelope expression. This vector functions as a replication competent mini-virus in a culture of NIH 3T3 derived semi-packaging cells that express the viral Gag and Pol proteins. Titers comparable to those of wild type virus were achieved by this system. To test this vector system, we created a random......The envelope protein of retroviruses is responsible for viral entry into host cells. Here, we describe a mutational library approach to dissect functional domains of the envelope protein involving a retroviral vector, which expresses both the envelope protein of Akv murine leukemia virus (MLV...... mutational library of Arg 85 and Asp 86 in the first variable region of Akv envelope protein. Homologous amino acids to Asp 86 in Moloney and Friend murine leukemia viruses are thought to be directly involved in receptor binding. Subsequent selection of mutants capable of infecting murine NIH 3T3 cells...

  10. Purified JC virus T antigen derived from insect cells preferentially interacts with binding site II of the viral core origin under replication conditions.

    Science.gov (United States)

    Bollag, B; Mackeen, P C; Frisque, R J

    1996-04-01

    The human polyomavirus JC virus (JCV) establishes persistent, asymptomatic infections in most individuals, but in severely immunocompromised hosts it may cause the fatal demyelinating brain disease progressive multifocal leukoencephalopathy. In cell culture JCV multiplies inefficiently and exhibits a narrow host range. This restricted behavior occurs, in part, at the level of DNA replication, which is regulated by JCV's multifunctional large tumor protein (TAg). To prepare purified JCV TAg (JCT) for biochemical analyses, the recombinant baculovirus B-JCT was generated by cotransfection of insect cells with wild-type baculovirus and the vector pVL-JCT(Int-) containing the JCT-coding sequence downstream of the efficient polyhedrin promoter. JCT expressed in infected cells was immunoaffinity purified using the anti-JCT monoclonal antibody PAb 2000. Characterization of the viral oncoprotein indicated that it exists in solution as a mixture of monomeric and oligomeric species. With the addition of ATP, the population of monomers decreased and that of hexamers and double hexamers increased. A DNA mobility shift assay indicated that origin binding occurred primarily with the double-hexamer form. A comparison of the specific DNA-binding activities of JCT and SV40 TAg (SVT) revealed that JCT generally exhibited greater affinity for binding site II relative to binding site I (B.S. I) of both viral origin regions, whereas SVT preferentially bound B.S. I. Furthermore, JCT bound nonviral DNA more efficiently than did SVT. These functional differences between the two TAgs may contribute to the reduced DNA replication potential of JCV in vitro, and to the virus' ability to establish persistent infections in vivo.

  11. Coagulation of carbon clusters in detonation front

    Science.gov (United States)

    Kupershtokh, A. L.; Ershov, A. P.; Medvedev, D. A.

    1996-05-01

    During the detonation synthesis, diamonds of ˜3 nm in size are produced from the excess carbon released in explosion. Coagulation occurs generally well below the melting temperature. Molecular dynamic simulations within the framework of simple Lennard-Jones model showed important features of interacting carbon clusters: 1) Coagulation is exothermic, and small clusters merge as liquid drops. Clusters larger than ˜3 nm unite keeping their shape, but surface atoms are in quasimolten state and can migrate between two grains. This "wetting" is rather slow. For small clusters there exist considerable temperature fluctuations due to interaction with the thermal bath. 2) Coagulation is accompanied by strong tensions. Both positive and negative pressure phases during the collision can reach ˜30 GPa. This can explain why the region of good diamond yield lies on P-T plane much higher than the graphite-diamond transition line.

  12. Monitoring of Biodistribution and Persistence of Conditionally Replicative Adenovirus in a Murine Model of Ovarian Cancer Using Capsid-Incorporated mCherry and Expression of Human Somatostatin Receptor Subtype 2 Gene

    Directory of Open Access Journals (Sweden)

    Igor P. Dmitriev

    2014-10-01

    Full Text Available A significant limiting factor to the human clinical application of conditionally replicative adenovirus (CRAd-based virotherapy is the inability to noninvasively monitor these agents and their potential persistence. To address this issue, we proposed a novel imaging approach that combines transient expression of the human somatostatin receptor (SSTR subtype 2 reporter gene with genetic labeling of the viral capsid with mCherry fluorescent protein. To test this dual modality system, we constructed the Ad5/3Δ24pIXcherry/SSTR CRAd and validated its capacity to generate fluorescent and nuclear signals in vitro and following intratumoral injection. Analysis of 64Cu-CB-TE2A-Y3-TATE biodistribution in mice revealed reduced uptake in tumors injected with the imaging CRAd relative to the replication-incompetent, Ad-expressing SSTR2 but significantly greater uptake compared to the negative CRAd control. Optical imaging demonstrated relative correlation of fluorescent signal with virus replication as determined by viral genome quantification in tumors. Positron emission tomography/computed tomography studies demonstrated that we can visualize radioactive uptake in tumors injected with imaging CRAd and the trend for greater uptake by standardized uptake value analysis compared to control CRAd. In the aggregate, the plasticity of our dual imaging approach should provide the technical basis for monitoring CRAd biodistribution and persistence in preclinical studies while offering potential utility for a range of clinical applications.

  13. DNA replication stress: causes, resolution and disease.

    Science.gov (United States)

    Mazouzi, Abdelghani; Velimezi, Georgia; Loizou, Joanna I

    2014-11-15

    DNA replication is a fundamental process of the cell that ensures accurate duplication of the genetic information and subsequent transfer to daughter cells. Various pertubations, originating from endogenous or exogenous sources, can interfere with proper progression and completion of the replication process, thus threatening genome integrity. Coordinated regulation of replication and the DNA damage response is therefore fundamental to counteract these challenges and ensure accurate synthesis of the genetic material under conditions of replication stress. In this review, we summarize the main sources of replication stress and the DNA damage signaling pathways that are activated in order to preserve genome integrity during DNA replication. We also discuss the association of replication stress and DNA damage in human disease and future perspectives in the field. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  14. Implementation of Smoothed Particle Hydrodynamics for Detonation of Explosive with Application to Rock Fragmentation

    Science.gov (United States)

    Pramanik, R.; Deb, D.

    2015-07-01

    The paper presents a methodology in the SPH framework to analyze physical phenomena those occur in detonation process of an explosive. It mainly investigates the dynamic failure mechanism in surrounding brittle rock media under blast-induced stress wave and expansion of high pressure product gases. A program burn model is implemented along with JWL equation of state to simulate the reaction zone in between unreacted explosive and product gas. Numerical examples of detonation of one- and two-dimensional explosive slab have been carried out to investigate the effect of reaction zone in detonation process and outward dispersion of gaseous product. The results are compared with those obtained from existing solutions. A procedure is also developed in SPH framework to apply continuity conditions between gas and rock interface boundaries. The modified Grady-Kipp damage model for the onset of tensile yielding and Drucker-Prager model for shear failure are implemented for elasto-plastic analysis of rock medium. The results show that high compressive stress causes high crack density in the vicinity of blast hole. The major principal stress (tensile) is responsible for forming radial cracks from the blast hole. Spalling zones are also developed due to stress waves reflected from the free surfaces.

  15. Radiation injury after a nuclear detonation: medical consequences and the need for scarce resources allocation.

    Science.gov (United States)

    DiCarlo, Andrea L; Maher, Carmen; Hick, John L; Hanfling, Dan; Dainiak, Nicholas; Chao, Nelson; Bader, Judith L; Coleman, C Norman; Weinstock, David M

    2011-03-01

    A 10-kiloton (kT) nuclear detonation within a US city could expose hundreds of thousands of people to radiation. The Scarce Resources for a Nuclear Detonation Project was undertaken to guide community planning and response in the aftermath of a nuclear detonation, when demand will greatly exceed available resources. This article reviews the pertinent literature on radiation injuries from human exposures and animal models to provide a foundation for the triage and management approaches outlined in this special issue. Whole-body doses >2 Gy can produce clinically significant acute radiation syndrome (ARS), which classically involves the hematologic, gastrointestinal, cutaneous, and cardiovascular/central nervous systems. The severity and presentation of ARS are affected by several factors, including radiation dose and dose rate, interindividual variability in radiation response, type of radiation (eg, gamma alone, gamma plus neutrons), partial-body shielding, and possibly age, sex, and certain preexisting medical conditions. The combination of radiation with trauma, burns, or both (ie, combined injury) confers a worse prognosis than the same dose of radiation alone. Supportive care measures, including fluid support, antibiotics, and possibly myeloid cytokines (eg, granulocyte colony-stimulating factor), can improve the prognosis for some irradiated casualties. Finally, expert guidance and surge capacity for casualties with ARS are available from the Radiation Emergency Medical Management Web site and the Radiation Injury Treatment Network.

  16. Type Ia Supernovae: Can Coriolis Force Break the Symmetry of the Gravitational Confined Detonation Explosion Mechanism?

    Science.gov (United States)

    García-Senz, D.; Cabezón, R. M.; Domínguez, I.; Thielemann, F. K.

    2016-03-01

    Currently the number of models aimed at explaining the phenomena of type Ia supernovae is high and distinguishing between them is a must. In this work we explore the influence of rotation on the evolution of the nuclear flame that drives the explosion in the so-called gravitational confined detonation models. Assuming that the flame starts in a pointlike region slightly above the center of the white dwarf (WD) and adding a moderate amount of angular velocity to the star we follow the evolution of the deflagration using a smoothed particle hydrodynamics code. We find that the results are very dependent on the angle between the rotational axis and the line connecting the initial bubble of burned material with the center of the WD at the moment of ignition. The impact of rotation is larger for angles close to 90° because the Coriolis force on a floating element of fluid is maximum and its principal effect is to break the symmetry of the deflagration. Such symmetry breaking weakens the convergence of the nuclear flame at the antipodes of the initial ignition volume, changing the environmental conditions around the convergence region with respect to non-rotating models. These changes seem to disfavor the emergence of a detonation in the compressed volume at the antipodes and may compromise the viability of the so-called gravitational confined detonation mechanism.

  17. TYPE Ia SUPERNOVAE: CAN CORIOLIS FORCE BREAK THE SYMMETRY OF THE GRAVITATIONAL CONFINED DETONATION EXPLOSION MECHANISM?

    Energy Technology Data Exchange (ETDEWEB)

    García-Senz, D. [Departament de Física, UPC, Comte d’Urgell 187, E-08036 Barcelona (Spain); Cabezón, R. M.; Thielemann, F. K. [Departement Physik, Universität Basel. Klingelbergstrasse, 82, 4056 Basel (Switzerland); Domínguez, I., E-mail: domingo.garcia@upc.edu, E-mail: ruben.cabezon@unibas.ch [Departamento de Física, Teórica y del Cosmos, Universidad de Granada, E-18071 Granada (Spain)

    2016-03-10

    Currently the number of models aimed at explaining the phenomena of type Ia supernovae is high and distinguishing between them is a must. In this work we explore the influence of rotation on the evolution of the nuclear flame that drives the explosion in the so-called gravitational confined detonation models. Assuming that the flame starts in a pointlike region slightly above the center of the white dwarf (WD) and adding a moderate amount of angular velocity to the star we follow the evolution of the deflagration using a smoothed particle hydrodynamics code. We find that the results are very dependent on the angle between the rotational axis and the line connecting the initial bubble of burned material with the center of the WD at the moment of ignition. The impact of rotation is larger for angles close to 90° because the Coriolis force on a floating element of fluid is maximum and its principal effect is to break the symmetry of the deflagration. Such symmetry breaking weakens the convergence of the nuclear flame at the antipodes of the initial ignition volume, changing the environmental conditions around the convergence region with respect to non-rotating models. These changes seem to disfavor the emergence of a detonation in the compressed volume at the antipodes and may compromise the viability of the so-called gravitational confined detonation mechanism.

  18. The spatial distribution patterns of condensed phase post-blast explosive residues formed during detonation.

    Science.gov (United States)

    Abdul-Karim, Nadia; Blackman, Christopher S; Gill, Philip P; Karu, Kersti

    2016-10-05

    The continued usage of explosive devices, as well as the ever growing threat of 'dirty' bombs necessitates a comprehensive understanding of particle dispersal during detonation events in order to develop effectual methods for targeting explosive and/or additive remediation efforts. Herein, the distribution of explosive analytes from controlled detonations of aluminised ammonium nitrate and an RDX-based explosive composition were established by systematically sampling sites positioned around each firing. This is the first experimental study to produce evidence that the post-blast residue mass can distribute according to an approximate inverse-square law model, while also demonstrating for the first time that distribution trends can vary depending on individual analytes. Furthermore, by incorporating blast-wave overpressure measurements, high-speed imaging for fireball volume recordings, and monitoring of environmental conditions, it was determined that the principle factor affecting all analyte dispersals was the wind direction, with other factors affecting specific analytes to varying degrees. The dispersal mechanism for explosive residue is primarily the smoke cloud, a finding which in itself has wider impacts on the environment and fundamental detonation theory.

  19. Theory of weakly nonlinear self-sustained detonations

    KAUST Repository

    Faria, Luiz M.

    2015-11-03

    We propose a theory of weakly nonlinear multidimensional self-sustained detonations based on asymptotic analysis of the reactive compressible Navier-Stokes equations. We show that these equations can be reduced to a model consisting of a forced unsteady small-disturbance transonic equation and a rate equation for the heat release. In one spatial dimension, the model simplifies to a forced Burgers equation. Through analysis, numerical calculations and comparison with the reactive Euler equations, the model is demonstrated to capture such essential dynamical characteristics of detonations as the steady-state structure, the linear stability spectrum, the period-doubling sequence of bifurcations and chaos in one-dimensional detonations and cellular structures in multidimensional detonations.

  20. Qualitative modeling of the dynamics of detonations with losses

    KAUST Repository

    Faria, Luiz

    2015-01-01

    We consider a simplified model for the dynamics of one-dimensional detonations with generic losses. It consists of a single partial differential equation that reproduces, at a qualitative level, the essential properties of unsteady detonation waves, including pulsating and chaotic solutions. In particular, we investigate the effects of shock curvature and friction losses on detonation dynamics. To calculate steady-state solutions, a novel approach to solving the detonation eigenvalue problem is introduced that avoids the well-known numerical difficulties associated with the presence of a sonic point. By using unsteady numerical simulations of the simplified model, we also explore the nonlinear stability of steady-state or quasi-steady solutions. © 2014 The Combustion Institute.

  1. Jaguar Analyses of Experimental Detonation Values for Aluminized Explosives

    Science.gov (United States)

    Stiel, Leonard I.; Baker, Ernest L.; Capellos, Christos

    2004-07-01

    Comparisons of JAGUAR C-J velocities with experimental detonation values for a number of explosives indicate that only slight, if any, aluminum reaction occurs at the detonation front even if small or sub-micron particles are utilized. For sub-micron particles, it is important to account for the presence of aluminum oxide in the explosive formulation. The agreement with the calculated JAGUAR values for zero aluminum reaction is within 2% for most experimental detonation velocities considered. Comparisons of experimental cylinder velocities by JAGUAR analytical procedures indicate that with small aluminum particles substantial aluminum reaction occurs at low values of the radial expansion, even though little reaction is observed at the detonation front.

  2. Chapman-Jouguet deflagrations and their transition to detonation

    CERN Document Server

    Saif, Mohamed; Pekalski, Andrzej; Levin, Marc; Radulescu, Matei I

    2015-01-01

    We study experimentally fast flames and their transition to detonation in mixtures of methane, ethane, ethylene, acetylene, and propane mixtures with oxygen. Following the interaction of a detonation wave with a column of cylinders of varying blockage ratio, the experiments demonstrate that the fast flames established are Chapman-Jouguet deflagrations, in excellent agreement with the self-similar model of Radulescu et al. (2015). The experiments indicate that these Chapman-Jouguet deflagrations dynamically restructure and amplify into fewer stronger modes until the eventual transition to detonation. The transition length to a self-sustained detonation was found to correlate very well with the mixtures' sensitivity to temperature fluctuations, reflected by the $\\chi$ parameter introduced by Radulescu, which is the product of the non-dimensional activation energy $E_a/RT$ and the ratio of chemical induction to reaction time $t_i/t_r$. Correlation of the measured DDT lengths determined that the relevant characte...

  3. [Detonation temperature measurement of epoxypropane using instantaneous spectrum method].

    Science.gov (United States)

    Li, Ying; Li, Ping; Xiao, Hai-Bo; Hu, Dong; Yuan, Chang-Ying

    2008-03-01

    After solving the problems of synchronization of the measuring system and the avoidance of false trigger signal, the instantaneous emission spectrum of epoxypropane with an exposure time of 2 micros and a resolution of 0.2 nm was acquired from a side window of a shock tube at the very moment when the epoxypropane transformed from deflagration to detonation. The measuring system consists of an advanced intensified charge-coupled-device spectroscopic detector, a digital delay generator DG535, an explosion shock tube and optical fibers. The DDT process was monitored by pressure transducers. After correcting the intensity of the spectrum obtained, the background curve of the heat radiation intensity of the detonation was given immediately. The detonation temperature of 2 416 K for epoxypropane was derived from fitting the curve with Planck blackbody formula by least squares principle. The detonation temperature of epoxypropane can provide an experimental datum for analyzing the microscopic mechanism of DDT process.

  4. Set-valued solutions for non-ideal detonation

    CERN Document Server

    Semenko, Roman; Kasimov, Aslan; Ermolaev, Boris

    2013-01-01

    The existence and structure of steady gaseous detonation propagating in a packed bed of solid inert particles are analyzed in the one-dimensional approximation by taking into consideration frictional and heat losses between the gas and the particles. A new formulation of the governing equations is introduced that eliminates the well-known difficulties with numerical integration across the sonic singularity in the reactive Euler equations. The new algorithm allows us to determine that the detonation solutions as the loss factors are varied have a set-valued nature at low detonation velocities when the sonic constraint disappears from the solutions. These set-valued solutions correspond to a continuous spectrum of the eigenvalue problem that determines the velocity of the detonation.

  5. On a stabilization mechanism for low-velocity detonations

    KAUST Repository

    Sow, Aliou

    2017-03-08

    We use numerical simulations of the reactive Lula equations to analyse the nonlinear stability of steady-state one-dimensional solutions for gaseous detonations in the presence of both momentum and heat losses. Our results point to a possible stabilization mechanism for the low-velocity detonations in such systems. The mechanism stems from the existence of a one-parameter family of solutions found in Semenko el al.

  6. Magnetohydrodynamic Augmentation of Pulse Detonation Rocket Engines (Preprint)

    Science.gov (United States)

    2010-09-28

    Detonation Rocket-Induced MHD Ejector (PDRIME) concept, energy could be extracted from the high speed portion of the system, e.g., through an MHD...but with some challenges associated with achieving these gains, suggesting further analysis and optimization are required. 15. SUBJECT TERMS 16...mentation, such as in the Pulse Detonation Rocket-Induced MHD Ejector (PDRIME) concept, energy could be extracted from the high speed por- tion of the system

  7. Numerical simulation of Mach reflection of cellular detonations

    Science.gov (United States)

    Li, J.; Lee, J. H. S.

    2016-09-01

    The Mach reflection of cellular detonation waves on a wedge is investigated numerically in an attempt to elucidate the effect of cellular instabilities on Mach reflection, the dependence of self-similarity on the thickness of a detonation wave, and the initial development of the Mach stem near the wedge apex. A two-step chain-branching reaction model is used to give a thermally neutral induction zone followed by a chemical reaction zone for the detonation wave. A sufficiently large distance of travel of the Mach stem is computed to observe the asymptotic behavior in the far field. Depending on the scale at which the Mach reflection process occurs, it is found that the Mach reflection of a cellular detonation behaves essentially in the same way as a planar ZND detonation wave. The cellular instabilities, however, cause the triple-point trajectory to fluctuate. The fluctuations are due to interactions of the triple point of the Mach stem with the transverse waves of cellular instabilities. In the vicinity of the wedge apex, the Mach reflection is found to be self-similar and corresponds to that of a shock wave of the same strength, since the Mach stem is highly overdriven initially. In the far field, the triple-point trajectory approaches a straight line, indicating that the Mach reflection becomes self-similar asymptotically. The distance of the approach to self-similarity is found to decrease rapidly with decreasing thickness of the detonation front.

  8. Detonation behavior of emulsion explosives sensitized with polymeric microballoons

    Science.gov (United States)

    Mendes, Ricardo; Ribeiro, José; Plaksin, Igor; Campos, José

    2013-06-01

    The differences between the detonation behavior of ammonium nitrate based emulsion explosive sensitized with polymeric or with glass microballoons is presented and discussed. Expancel® are hollow polymeric microballoons that contain a hydrocarbon gas. The mean particle size of those particles is 30 μm and their wall thickness is about 0.1 μm. The detonation velocity and the failure diameter of the emulsion explosive sensitized with different amounts of these particles were measured, in cylindrical charges, by ionization pins and optical fibers. The detonation velocity of emulsion explosives shows a non-monotonic evolution with the density with the maximum being reached far below the maximum density. The detonation fails when the density approaches the one of the matrix. The failure diameter increases with increasing density. For low densities the detonation velocity is almost independent of the charge diameter and it is close to the values predict by BKW EoS. The effect of the nature and size of the microballoons on the detonation front curvature and failure diameter was also determined.

  9. Non ideal detonation of emulsion explosives mixed with metal particles

    Science.gov (United States)

    Mendes, R.; Ribeiro, J.; Plaksin, I.; Campos, J.

    2011-06-01

    The detonation of ammonium nitrate based compositions like emulsion explosives (EX) mixed with metal particles has been investigated experimentally. Aluminium powder with a mean particle size of 10 μm was used, and the mass concentration of aluminum on the explosive charge was ranged from 0 to 30%. The values of the detonation velocity, the pressure attenuation - P(x) - of detonation front amplitude in a standard PMMA monitor and manganin gauges pressure-time histories are shown as a function of the explosive charge porosity and specific mass. All these parameters except the pressure-times histories have been evaluated using the multi fiber optical probe (MFOP) method which is based on the use of an optical fiber strip, with 64 independent optical fibers. The MFOP allow a quasi continuous evaluation of the detonation wave run propagation and the assessment to spatial resolved measurements of the shock wave induced in the PMMA barrier which in turns allows a detailed characterization of the detonation reaction zone structure. Results of that characterization process are presented and discussed for aluminized and non aluminized EX. Moreover, the effect of the mass concentration of the sensitizing agent (hollow glass micro-balloons) on the non monotonic detonation velocity variation, for EX, will be discussed.

  10. Compartmentalized self-replication under fast PCR cycling conditions yields Taq DNA polymerase mutants with increased DNA-binding affinity and blood resistance.

    Science.gov (United States)

    Arezi, Bahram; McKinney, Nancy; Hansen, Connie; Cayouette, Michelle; Fox, Jeffrey; Chen, Keith; Lapira, Jennifer; Hamilton, Sarah; Hogrefe, Holly

    2014-01-01

    Faster-cycling PCR formulations, protocols, and instruments have been developed to address the need for increased throughput and shorter turn-around times for PCR-based assays. Although run times can be cut by up to 50%, shorter cycle times have been correlated with lower detection sensitivity and increased variability. To address these concerns, we applied Compartmentalized Self Replication (CSR) to evolve faster-cycling mutants of Taq DNA polymerase. After five rounds of selection using progressively shorter PCR extension times, individual mutations identified in the fastest-cycling clones were randomly combined using ligation-based multi-site mutagenesis. The best-performing combinatorial mutants exhibit 35- to 90-fold higher affinity (lower Kd ) for primed template and a moderate (2-fold) increase in extension rate compared to wild-type Taq. Further characterization revealed that CSR-selected mutations provide increased resistance to inhibitors, and most notably, enable direct amplification from up to 65% whole blood. We discuss the contribution of individual mutations to fast-cycling and blood-resistant phenotypes.

  11. Compartmentalized Self-Replication under fast PCR cycling conditions yields Taq DNA polymerase mutants with increased DNA-binding affinity and blood resistance

    Directory of Open Access Journals (Sweden)

    Bahram eArezi

    2014-08-01

    Full Text Available Faster-cycling PCR formulations, protocols, and instruments have been developed to address the need for increased throughput and shorter turn-around times for PCR-based assays. Although run times can be cut by up to 50%, shorter cycle times have been correlated with lower detection sensitivity and increased variability. To address these concerns, we applied Compartmentalized Self Replication (CSR to evolve faster-cycling mutants of Taq DNA polymerase. After five rounds of selection using progressively shorter PCR extension times, individual mutations identified in the fastest-cycling clones were randomly combined using ligation-based multi-site mutagenesis. The best-performing combinatorial mutants exhibit 35- to 90-fold higher affinity (lower Kd for primed template and a moderate (2-fold increase in extension rate compared to wild-type Taq. Further characterization revealed that CSR-selected mutations provide increased resistance to inhibitors, and most notably, enable direct amplification from up to 65% whole blood. We discuss the contribution of individual mutations to fast-cycling and blood-resistant phenotypes.

  12. A small-scale experiment using microwave interferometry to investigate detonation and shock-to-detonation transition in pressed TATB

    Science.gov (United States)

    Renslow, Peter John

    A small-scale characterization test utilizing microwave interferometry was developed to dynamically measure detonation and run to detonation distance in explosives. The technique was demonstrated by conducting two experimental series on the well-characterized explosive triaminotrinitrobenzene (TATB). In the first experiment series, the detonation velocity was observed at varying porosity. The velocity during TATB detonation matched well with predictions made using CHEETAH and an empirical relation from the Los Alamos National Laboratory (LANL). The microwave interferometer also captured unsteady propagation of the reaction when a low density charge was near the failure diameter. In the second experiment series, Pop-plots were produced using data obtained from shock initiation of the TATB through a polymethyl methacrylate (PMMA) attenuator. The results compared well to wedge test data from LANL despite the microwave interferometer test being of substantially smaller scale. The results showed the test method is attractive for rapid characterization of new and improvised explosive materials.

  13. Replication Restart in Bacteria.

    Science.gov (United States)

    Michel, Bénédicte; Sandler, Steven J

    2017-07-01

    In bacteria, replication forks assembled at a replication origin travel to the terminus, often a few megabases away. They may encounter obstacles that trigger replisome disassembly, rendering replication restart from abandoned forks crucial for cell viability. During the past 25 years, the genes that encode replication restart proteins have been identified and genetically characterized. In parallel, the enzymes were purified and analyzed in vitro, where they can catalyze replication initiation in a sequence-independent manner from fork-like DNA structures. This work also revealed a close link between replication and homologous recombination, as replication restart from recombination intermediates is an essential step of DNA double-strand break repair in bacteria and, conversely, arrested replication forks can be acted upon by recombination proteins and converted into various recombination substrates. In this review, we summarize this intense period of research that led to the characterization of the ubiquitous replication restart protein PriA and its partners, to the definition of several replication restart pathways in vivo, and to the description of tight links between replication and homologous recombination, responsible for the importance of replication restart in the maintenance of genome stability. Copyright © 2017 American Society for Microbiology.

  14. The criterion of the existence or inexistence of transverse shock wave at wedge supported oblique detonation wave

    Institute of Scientific and Technical Information of China (English)

    Ai-Feng Wang; Wei Zhao; Zong-Lin Jiang

    2011-01-01

    A simplified theoretic method and numerical simulations were carried out to investigate the characterization of propagation of transverse shock wave at wedge supported oblique detonation wave.After solution validation,a criterlon which is associated with the ratio φ (u2/ucJ) of existence or inexistence of the transverse shock wave at the region of the primary triple was deduced systematically by 38 cases.It is observed that for abrupt oblique shock wave (OSW)/oblique detonation wave (ODW) transition,a transverse shock wave is generated at the region of the primary triple when φ < 1,however,such a transverse shock wave does not take place for the smooth OSW/ODW transition when φ > 1.The parameter φ can be expressed as the Mach number behind the ODW front for stable CJ detonation.When 0.9 < φ < 1.0,the reflected shock wave can pass across the contact discontinuity and interact with transverse waves which are originating from the ODW front.When 0.8 < φ < 0.9,the reflected shock wave can not pass across the contact discontinuity and only reflects at the contact discontinuity.The condition (0.8 < φ < 0.9) agrees well with the ratio (Dave/DcJ) in the critical detonation.

  15. Detonation properties of 1,1-diamino-2,2-dinitroethene (DADNE).

    Science.gov (United States)

    Trzciński, Waldemar A; Cudziło, Stanisław; Chyłek, Zbigniew; Szymańczyk, Leszek

    2008-09-15

    1,1-Diamino-2,2-dinitroethene (DADNE, FOX-7) is an explosive of current interest. In our work, an advanced study of detonation characteristics of this explosive was performed. DADNE was prepared and recrystallized on a laboratory scale. Some sensitivity and detonation properties of DADNE were determined. The detonation performance was established by measurements of the detonation wave velocity, detonation pressure and calorimetric heat of explosion as well as the accelerating ability. The JWL (Jones-Wilkins-Lee) isentrope and the constant-gamma isentrope for the detonation products of DADNE were also found.

  16. HERMES: A Model to Describe Deformation, Burning, Explosion, and Detonation

    Energy Technology Data Exchange (ETDEWEB)

    Reaugh, J E

    2011-11-22

    HERMES (High Explosive Response to MEchanical Stimulus) was developed to fill the need for a model to describe an explosive response of the type described as BVR (Burn to Violent Response) or HEVR (High Explosive Violent Response). Characteristically this response leaves a substantial amount of explosive unconsumed, the time to reaction is long, and the peak pressure developed is low. In contrast, detonations characteristically consume all explosive present, the time to reaction is short, and peak pressures are high. However, most of the previous models to describe explosive response were models for detonation. The earliest models to describe the response of explosives to mechanical stimulus in computer simulations were applied to intentional detonation (performance) of nearly ideal explosives. In this case, an ideal explosive is one with a vanishingly small reaction zone. A detonation is supersonic with respect to the undetonated explosive (reactant). The reactant cannot respond to the pressure of the detonation before the detonation front arrives, so the precise compressibility of the reactant does not matter. Further, the mesh sizes that were practical for the computer resources then available were large with respect to the reaction zone. As a result, methods then used to model detonations, known as {beta}-burn or program burn, were not intended to resolve the structure of the reaction zone. Instead, these methods spread the detonation front over a few finite-difference zones, in the same spirit that artificial viscosity is used to spread the shock front in inert materials over a few finite-difference zones. These methods are still widely used when the structure of the reaction zone and the build-up to detonation are unimportant. Later detonation models resolved the reaction zone. These models were applied both to performance, particularly as it is affected by the size of the charge, and to situations in which the stimulus was less than that needed for reliable

  17. HERMES: A Model to Describe Deformation, Burning, Explosion, and Detonation

    Energy Technology Data Exchange (ETDEWEB)

    Reaugh, J E

    2011-11-22

    HERMES (High Explosive Response to MEchanical Stimulus) was developed to fill the need for a model to describe an explosive response of the type described as BVR (Burn to Violent Response) or HEVR (High Explosive Violent Response). Characteristically this response leaves a substantial amount of explosive unconsumed, the time to reaction is long, and the peak pressure developed is low. In contrast, detonations characteristically consume all explosive present, the time to reaction is short, and peak pressures are high. However, most of the previous models to describe explosive response were models for detonation. The earliest models to describe the response of explosives to mechanical stimulus in computer simulations were applied to intentional detonation (performance) of nearly ideal explosives. In this case, an ideal explosive is one with a vanishingly small reaction zone. A detonation is supersonic with respect to the undetonated explosive (reactant). The reactant cannot respond to the pressure of the detonation before the detonation front arrives, so the precise compressibility of the reactant does not matter. Further, the mesh sizes that were practical for the computer resources then available were large with respect to the reaction zone. As a result, methods then used to model detonations, known as {beta}-burn or program burn, were not intended to resolve the structure of the reaction zone. Instead, these methods spread the detonation front over a few finite-difference zones, in the same spirit that artificial viscosity is used to spread the shock front in inert materials over a few finite-difference zones. These methods are still widely used when the structure of the reaction zone and the build-up to detonation are unimportant. Later detonation models resolved the reaction zone. These models were applied both to performance, particularly as it is affected by the size of the charge, and to situations in which the stimulus was less than that needed for reliable

  18. Analysis of supercritical vapor explosions using thermal detonation wave theory

    Energy Technology Data Exchange (ETDEWEB)

    Shamoun, B.I.; Corradini, M.L. [Univ. of Wisconsin, Madison, WI (United States)

    1995-09-01

    The interaction of certain materials such as Al{sub 2}O{sub 3} with water results in vapor explosions with very high (supercritical) pressures and propagation velocities. A quasi-steady state analysis of supercritical detonation in one-dimensional multiphase flow was applied to analyze experimental data of the KROTOS (26-30) set of experiments conducted at the Joint Research Center at Ispra, Italy. In this work we have applied a new method of solution which allows for partial fragmentation of the fuel in the shock adiabatic thermodynamic model. This method uses known experiment values of the shock pressure and propagation velocity to estimate the initial mixing conditions of the experiment. The fuel and coolant were both considered compressible in this analysis. In KROTOS 26, 28, 29, and 30 the measured values of the shock pressure by the experiment were found to be higher than 25, 50, 100, and 100 Mpa respectively. Using the above data for the wave velocity and our best estimate for the values of the pressure, the predicted minimum values of the fragmented mass of the fuel were found to be 0.026. 0.04, 0.057, and 0.068 kg respectively. The predicted values of the work output corresponding to the above fragmented masses of the fuel were found to be 40, 84, 126, and 150 kJ respectively, with predicted initial void fractions of 112%, 12.5%, 8%, and 6% respectively.

  19. TRENDS IN THE DEVELOPMENT OF DETONATION ENGINES FOR HIGH-SPEED AEROSPACE AIRCRAFTS AND THE PROBLEM OF TRIPLE CONFIGURATIONS OF SHOCK WAVES. Part I. Research of detonation engines

    Directory of Open Access Journals (Sweden)

    P. V. Bulat

    2016-01-01

    Full Text Available We consider current problems of improving propulsion systems of highly supersonic air-space vehicles. In the first part, we review historic developments and list the landmark scientific papers. Classification of detonation engines is presented with detailed consideration of rotation detonation engines and continuous detonation engines. Experimental results on detonation, which are of particular importance for the design of detonation engines, are discussed. The second part of the paper provides an overview of the development in detonation theory, mathematical modelling, and numerical simulation. We focus on the interference of shock waves with formation of triple points, regular and irregular reflection of shock waves, existence of multiple solutions and the resulting appearance of hysteresis. The relevance and importance of triple shock wave configurations for the development of new types of air intakes and detonation jet engines is demonstrated.

  20. Reducing the Consequences of a Nuclear Detonation.

    Energy Technology Data Exchange (ETDEWEB)

    Buddemeier, B R

    2007-11-09

    The 2002 National Strategy to Combat Weapons of Mass Destruction states that 'the United States must be prepared to respond to the use of WMD against our citizens, our military forces, and those of friends and allies'. Scenario No.1 of the 15 Department of Homeland Security national planning scenarios is an improvised nuclear detonation in the national capitol region. An effective response involves managing large-scale incident response, mass casualty, mass evacuation, and mass decontamination issues. Preparedness planning activities based on this scenario provided difficult challenges in time critical decision making and managing a large number of casualties within the hazard area. Perhaps even more challenging is the need to coordinate a large scale response across multiple jurisdictions and effectively responding with limited infrastructure and resources. Federal response planning continues to make improvements in coordination and recommending protective actions, but much work remains. The most critical life-saving activity depends on actions taken in the first few minutes and hours of an event. The most effective way to reduce the enormous national and international social and economic disruptions from a domestic nuclear explosion is through planning and rapid action, from the individual to the federal response. Anticipating response resources for survivors based on predicted types and distributions of injuries needs to be addressed.

  1. Detonation Type Ram Accelerator: A Computational Investigation

    Directory of Open Access Journals (Sweden)

    Sunil Bhat

    2000-01-01

    Full Text Available An analytical model explaining the functional characteristics of detonation type ram accelerator is presented. Major flow processes, namely, (i supersonic flow over the cone of the projectile, (ii initiation ofconical shock wave and its reflection from the tube wall, (iii supersonic combustion, and (iv expansion wave and its reflection are modelled. Taylor-Maccoll approach is adopted for modellingthe flow over the cone of the projectile. Shock reflection is treated in accordance with wave angle theorytor flows over the wedge. Prandtl-Mayer analysis is used to model the expansion wave and its reflection.Steady one-dimensional flow with heat transfer along with Rayleigh line equation for perfect gases isused to model supersonic combustion. A computer code is developed to compute the thrust producedby combustion of gases. Ballistic parameters like thrust-pressure ratio and ballistic efficiency of the accelerator are evaluated and their maximum values are 0.032 and 0.068, respectively. The code indicates possibility ofachieving high velocity of 7 km/s on utilising gaseous mixture of 2H2+O2 in the operation.Velocity range suitable for operation of the accelerator lies between 3.8 - 7.0 km/s. Maximum thrust valueis 33721 N which corresponds to the projectile velocity of 5 km/s.

  2. Detonation Structure Under Chain Branching Kinetics

    Science.gov (United States)

    Liang, Z.; Bauwens, L.

    2006-07-01

    Hydrogen-oxygen chemistry is characterized by a chain branching mechanism that yields three explosion limits. While a detailed kinetic scheme appropriate for hydrogen-oxygen should produce correct results, in many circumstances, a simpler yet reasonably realistic model will be warranted. In particular, it is easier to develop a clear understanding of the reaction zone structure using a simpler model, that includes only the key mechanisms. To that effect, we consider a four-step chain branching scheme that exhibits an explosion behavior with three limits, which behaves at least qualitatively like hydrogen chemistry. We focus in particular on the structure of the initiation and chain branching zones, using a combination between numerical simulation and analysis. Numerical simulations using this chemical model show distinctive keystone figures in the flow field, close to observations in hydrogen-oxygen detonation experiments. The structure of the chain branching zone is resolved using a perturbation analysis, which clarifies the differences between explosion and no-explosion regions and allows for an evaluation of the induction length in the steady wave. The analysis assumes both high activation energy and a slow initiation. Three cases are identified, respectively, with pressure and temperature located within the explosion region, close to the explosion limit and within the no-explosion region. The induction length is shorter and the reaction rate is faster by several orders of magnitude in the explosion region.

  3. Numerical simulation of detonation failure in nitromethane

    Energy Technology Data Exchange (ETDEWEB)

    Kipp, M E; Nunziato, J W

    1981-01-01

    Detonation failure in the homogeneous liquid explosive nitromethane has been observed experimentally in a wide variety of confining geometries. However, numerical simulation of these failure situations with a wave propagation code has been essentially non-existent due to the large differences between the critical diameter and the length of the reaction zone - characteristic dimensions which differ by about two orders of magnitude. This inability to spatially resolve both the reaction zone and geometries of significant size has led us to propose a new numerical technique, based on the stability criterion for rate-type material models, in which only temporal resolution of the reaction zone is required. Using an improved model for nitromethane, we have carried out a series of two-dimensional calculations which illustrate the utility of the present approach in predicting a wide range of experimental observations. Of particular computational significance is the removal of the difficulty requiring spatial resolution of the reaction zone, so that problems of practical size can be analyzed with existing computer capabilities.

  4. Color camera pyrometry for high explosive detonations

    Science.gov (United States)

    Densmore, John; Biss, Matthew; Homan, Barrie; McNesby, Kevin

    2011-06-01

    Temperature measurements of high-explosive and combustion processes are difficult because of the speed and environment of the events. We have characterized and calibrated a digital high-speed color camera that may be used as an optical pyrometer to overcome these challenges. The camera provides both high temporal and spatial resolution. The color filter array of the sensor uses three color filters to measure the spectral distribution of the imaged light. A two-color ratio method is used to calculate a temperature using the color filter array raw image data and a gray-body assumption. If the raw image data is not available, temperatures may be calculated from processed images or movies depending on proper analysis of the digital color imaging pipeline. We analyze three transformations within the pipeline (demosaicing, white balance, and gamma-correction) to determine their effect on the calculated temperature. Using this technique with a Vision Research Phantom color camera, we have measured the temperature of exploded C-4 charges. The surface temperature of the resulting fireball rapidly increases after detonation and then decayed to a constant value of approximately 1980 K. Processed images indicates that the temperature remains constant until the light intensity decreased below the background value.

  5. Evidence for an unorthodox firing sequence employed by the Berlin Painter : deciphering ancient ceramic firing conditions through high-resolution material characterization and replication

    NARCIS (Netherlands)

    Cianchetta, I.; Trentelman, K.; Maish, J.; Saunders, D.; Foran, B.; Walton, M.; Sciau, Ph.; Wang, T.; Pouyet, E.; Cotte, M.; Meirer, F.; Liu, Y.; Pianetta, P.; Mehta, A.

    2015-01-01

    XANES spectroscopy was used to complement the results previously obtained with Raman spectroscopy by the same group to determine the firing conditions used in the production of a single vessel painted by the Berlin Painter in the 5th century B.C. The vessel, part of the collection of the J. Paul Get

  6. Regulation of Unperturbed DNA Replication by Ubiquitylation

    Directory of Open Access Journals (Sweden)

    Sara Priego Moreno

    2015-06-01

    Full Text Available Posttranslational modification of proteins by means of attachment of a small globular protein ubiquitin (i.e., ubiquitylation represents one of the most abundant and versatile mechanisms of protein regulation employed by eukaryotic cells. Ubiquitylation influences almost every cellular process and its key role in coordination of the DNA damage response is well established. In this review we focus, however, on the ways ubiquitylation controls the process of unperturbed DNA replication. We summarise the accumulated knowledge showing the leading role of ubiquitin driven protein degradation in setting up conditions favourable for replication origin licensing and S-phase entry. Importantly, we also present the emerging major role of ubiquitylation in coordination of the active DNA replication process: preventing re-replication, regulating the progression of DNA replication forks, chromatin re-establishment and disassembly of the replisome at the termination of replication forks.

  7. Reflected Detonation Waves: Comparing Theory to Pressure and Heat Flux Measurements

    Science.gov (United States)

    Damazo, J.; Shepherd, J. E.

    Gaseous detonations are of concern to engineers designing piping systems for chemical and nuclear processing facilities. Recently, engineers have also begun to explore the possibility of harnessing the impulse created by detonations for thrust.

  8. Dynamics of detonations with a constant mean flow divergence

    CERN Document Server

    Borzou, Bijan

    2016-01-01

    The present work addresses the question of whether mean field macroscopic models are suitable to describe the dynamics of real cellular detonations. This question is posed in the framework of detonations with stream-tube area divergence that is kept constant, as to generate attenuated detonations in quasi-steady state. An exponential horn geometry is used, in order to keep the source term due to geometrical divergence constant in the governing equations of mean flow, and hence permit to establish steady travelling waves with constant losses. The experiments were conducted in two mixtures 2C$_2$H$_2$+5O$_2$+21Ar, characterized by a relatively weak instability, and C$_3$H$_8$+5O$_2$, characterized by a much more unstable cellular structure. The experiments demonstrated that such quasi-steady state detonations can be realized. The experiments permitted a unique detonation speed - divergence scaling laws to be developed. Quantitative comparisons were made with steady wave predictions based on the underlying chemi...

  9. Helium in Double-Detonation Models of Type Ia Supernovae

    CERN Document Server

    Boyle, Aoife; Hachinger, Stephan; Kerzendorf, Wolfgang

    2016-01-01

    The double-detonation explosion model has been considered a candidate for explaining astrophysical transients with a wide range of luminosities. In this model, a carbon-oxygen white dwarf star explodes following detonation of a surface layer of helium. One potential signature of this explosion mechanism is the presence of unburned helium in the outer ejecta, left over from the surface helium layer. In this paper we present simple approximations to estimate the optical depths of important He I lines in the ejecta of double-detonation models. We use these approximations to compute synthetic spectra, including the He I lines, for double-detonation models obtained from hydrodynamical explosion simulations. Specifically, we focus on photospheric-phase predictions for the near-infrared 10830 \\AA~and 2 $\\mu$m lines of He I. We first consider a double detonation model with a luminosity corresponding roughly to normal SNe Ia. This model has a post-explosion unburned He mass of 0.03 $M_{\\odot}$ and our calculations sug...

  10. Non ideal detonation of emulsion explosives mixed with metal particles

    Science.gov (United States)

    Mendes, Ricardo; Ribeiro, José B.; Plaksin, I.; Campos, Jose

    2012-03-01

    The detonation of ammonium nitrate based compositions like emulsion explosives mixed with metal particles was experimentally investigated. Aluminum powder with a mean particle size of 6 μm was used, and the mass concentration of aluminum on the explosive charge ranged from 0 to 30% wt. The values of the detonation velocity, the pressure attenuation - P(x) - of the shock front amplitude in a standard PMMA monitor and manganin gauges pressure-time histories are shown as a function of the explosive charge porosity and specific mass. All these parameters except the pressuretimes histories have been evaluated using the multi-fiber optical probe (MFOP) method which is based on the use of an optical fiber strip, with 64 independent optical fibers. The MFOP allows a quasicontinuous evaluation of the detonation wave run propagation and the assessment of spatial resolved measurements of the shock wave induced in the PMMA barrier. Results of that characterization process are presented and discussed for aluminized and non-aluminized emulsion explosives. The experimental results have shown that the detonation velocity decreases monotonically with the increase of aluminum content. Nevertheless the peak of detonation pressure profiles presents a non-monotonic behavior increasing its value up to an Al content of 20% wt, after which it starts to decrease.

  11. Detonation tube impulse in sub-atmospheric environments.

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, Marcia A.; Shepherd, Joseph E. (California Institute of Technology, Pasadena, CA)

    2005-04-01

    The thrust from a multi-cycle, pulse detonation engine operating at practical flight altitudes will vary with the surrounding environment pressure. We have carried out the first experimental study using a detonation tube hung in a ballistic pendulum arrangement within a large pressure vessel in order to determine the effect that the environment has on the single-cycle impulse. The air pressure inside the vessel surrounding the detonation tube varied between 100 and 1.4 kPa while the initial pressure of the stoichiometric ethylene-oxygen mixture inside the tube varied between 100 and 30 kPa. The original impulse model (Wintenberger et al., Journal of Propulsion and Power, Vol. 19, No. 1, 2002) was modified to predict the observed increase in impulse and blow down time as the environment pressure decreased below one atmosphere. Comparisons between the impulse from detonation tubes and ideal, steady flow rockets indicate incomplete expansion of the detonation tube exhaust, resulting in a 37% difference in impulse at a pressure ratio (ratio of pressure behind the Taylor wave to the environment pressure) of 100.

  12. Investigations on detonation shock dynamics and related topics. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, D.S. [Univ. of Illinois, Urbana, IL (United States). Dept. of Theoretical and Applied Mechanics

    1993-11-01

    This document is a final report that summarizes the research findings and research activities supported by the subcontract DOE-LANL-9-XG8-3931P-1 between the University of Illinois (D. S. Stewart Principal Investigator) and the University of California (Los Alamos National Laboratory, M-Division). The main focus of the work has been on investigations of Detonation Shock Dynamics. A second emphasis has been on modeling compaction of energetic materials and deflagration to detonation in those materials. The work has led to a number of extensions of the theory of Detonation Shock Dynamics (DSD) and its application as an engineering design method for high explosive systems. The work also enhanced the hydrocode capabilities of researchers in M-Division by modifications to CAVEAT, an existing Los Alamos hydrocode. Linear stability studies of detonation flows were carried out for the purpose of code verification. This work also broadened the existing theory for detonation. The work in this contract has led to the development of one-phase models for dynamic compaction of porous energetic materials and laid the groundwork for subsequent studies. Some work that modeled the discrete heterogeneous behavior of propellant beds was also performed. The contract supported the efforts of D. S. Stewart and a Postdoctoral student H. I. Lee at the University of Illinois.

  13. Failed-Detonation Supernovae: Sub-Luminous Low-Velocity Ia Supernovae and Their Remnant-Kicked Iron-Core White Dwarfs

    CERN Document Server

    Jordan, George C; Fisher, Robert T; van Rossum, Daniel R

    2012-01-01

    Type Ia supernovae (SNe Ia) are thought to originate from the thermonuclear explosions of carbon-oxygen (C-O) white dwarfs (WDs). The gravitationally-confined detonation (GCD) model is a well-explored explosion model where unstable thermonuclear burning initiates in an accreting, Chandrasekhar-mass WD and forms an advancing flame. Rising, burning material breaks out of the WD surface, engulfs the WD, and leads to a gradient-induced detonation in the collision region, which subsequently unbinds the WD. We show that when the flame consumes enough fuel, the conditions for detonation are not met, and the WD does not detonate. We show through 2D and 3D simulations, such failed-detonation SNe expel a few 0.1 Msolar of burned and partially-burned material, but do not unbind the WD. A fraction of the material falls back onto the WD, polluting the remnant WD with intermediate-mass and iron-group elements, that likely segregate to the core forming an iron-core C-O WD. The remaining material is asymmetrically ejected at...

  14. Emission Spectroscopy of the Interior of Optically Dense Post-Detonation Fireballs

    Science.gov (United States)

    2013-03-01

    TP-2013-011 Emission Spectroscopy of the Interior of Optically Dense Post-Detonation Fireballs Distribution A: Approved for public release...Detonation Fireballs 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 62102F 6. AUTHOR(S) W.K. Lewis1, C.G. Rumchik2, M.J...detonation fireballs that form as under- oxidized detonation products burn in the surrounding air are optically dense and the corresponding emission

  15. DNA replication and cancer

    DEFF Research Database (Denmark)

    Boyer, Anne-Sophie; Walter, David; Sørensen, Claus Storgaard

    2016-01-01

    A dividing cell has to duplicate its DNA precisely once during the cell cycle to preserve genome integrity avoiding the accumulation of genetic aberrations that promote diseases such as cancer. A large number of endogenous impacts can challenge DNA replication and cells harbor a battery of pathways...... causing DNA replication stress and genome instability. Further, we describe cellular and systemic responses to these insults with a focus on DNA replication restart pathways. Finally, we discuss the therapeutic potential of exploiting intrinsic replicative stress in cancer cells for targeted therapy....

  16. Mechanisms of direct detonation initiation via thermal explosion of radiatively heated gas-particles layer

    Science.gov (United States)

    Efremov, V. P.; Ivanov, M. F.; Kiverin, A. D.; Yakovenko, I. S.

    Conceptual approach of detonation wave direct initiation by external radiative heating of microparticles locally suspended in flammable gaseous mixture is proposed. Combustion waves and detonation initiation mechanisms in the congestion regions of microparticles heated by radiation are studied numerically. Necessary criteria on geometrical scales of gas-particles layer and spatial uniformity of particles distribution for successful detonation initiation are formulated.

  17. Reproducibility Distinguishability and Correlation of Fireball and Shockwave Dynamics in Explosive Munitions Detonations

    Science.gov (United States)

    2006-03-01

    plots, heat of detonation (which follows the same correlation as the specific afterburn energy) initial mass in the lower plots. As all quantities...fireball area increases with the third power of the heat of detonation , neglecting the outliers...third power of the heat of detonation , neglecting the outliers. In all cases, correlation is higher than when C-4 was included

  18. Mathematical modeling of detonation initiation via flow cumulation effects

    Science.gov (United States)

    Semenov, I.; Utkin, P.; Akhmedyanov, I.

    2016-07-01

    The paper concerns two problems connected with the idea of gaseous detonation initiation via flow cumulation effects and convergence of relatively weak shock waves (SW). The first one is the three-dimensional (3D) numerical investigation of shock-to-detonation transition (SDT) in methane-air mixture in a tube with parabolic contraction followed by the tube section of narrow diameter and conical expansion. The second problem is the numerical study of the start-up of the model small-scale hydrogen electrochemical pulse detonation engine with the use of electrical discharge generating the toroidal SW. The investigation is performed by means of numerical simulation with the use of modern high-performance computing systems.

  19. Parametric Study of High Frequency Pulse Detonation Tubes

    Science.gov (United States)

    Cutler, Anderw D.

    2008-01-01

    This paper describes development of high frequency pulse detonation tubes similar to a small pulse detonation engine (PDE). A high-speed valve injects a charge of a mixture of fuel and air at rates of up to 1000 Hz into a constant area tube closed at one end. The reactants detonate in the tube and the products exit as a pulsed jet. High frequency pressure transducers are used to monitor the pressure fluctuations in the device and thrust is measured with a balance. The effects of injection frequency, fuel and air flow rates, tube length, and injection location are considered. Both H2 and C2H4 fuels are considered. Optimum (maximum specific thrust) fuel-air compositions and resonant frequencies are identified. Results are compared to PDE calculations. Design rules are postulated and applications to aerodynamic flow control and propulsion are discussed.

  20. Ferrite core coupled slapper detonator apparatus and method

    Science.gov (United States)

    Boberg, Ralph E.; Lee, Ronald S.; Weingart, Richard C.

    1989-01-01

    Method and apparatus are provided for coupling a temporally short electric power pulse from a thick flat-conductor power cable into a thin flat-conductor slapper detonator circuit. A first planar and generally circular loop is formed from an end portion of the power cable. A second planar and generally circular loop, of similar diameter, is formed from all or part of the slapper detonator circuit. The two loops are placed together, within a ferrite housing that provides a ferrite path that magnetically couples the two loops. Slapper detonator parts may be incorporated within the ferrite housing. The ferrite housing may be made vacuum and water-tight, with the addition of a hermetic ceramic seal, and provided with an enclosure for protecting the power cable and parts related thereto.

  1. Influence of Accelerated Aging on Detonation Performance of Explosives

    Institute of Scientific and Technical Information of China (English)

    GAO Da-yuan; HUA Cheng; WANG Xiang; HAN Yong

    2010-01-01

    To understand the aging effects on detonation performances of explosives, an accelerated aging mechanism and effect of explosives were analyzed. Based on the thermo-gravimetric (TG) curves of explosives under the heat rate of 5, 10 and 20 K·min-1, the thermal decomposition activation energy, pre-exponential factor, mechanism function and kinetic equation of the explosives were calculated by Ozawa's equation and decomposition extents. Then, according to the derived kinetic equation, the density, composition and heat of formation of GI-1, PBX-1 and PBX-2 explosive in different decompo-sition extents were calculated at accelerated aging temperatures of 70 ℃ and 75 ℃, respectively. Furthermore, the detona-tion parameters of GI-1, PBX-1 and PBX-2 explosives were found out by means of VLWR code. The results show that after accelerated aging, the density are decrease, the detonation velocity and pressure are all decreased slightly.

  2. The analysis of thermal stability of detonation nanodiamond

    Science.gov (United States)

    Efremov, V. P.; Zakatilova, E. I.

    2016-11-01

    The detonation nanodiamond is a new perspective material. Ammunition recycling with use of high explosives and obtaining nanodiamond as the result of the detonation synthesis have given a new motivation for searching of their application areas. In this work nanodiamond powder has been investigated by the method of synchronous thermal analysis. Experiments have been carried out at atmospheric pressure in the environment of argon. Nanodiamond powder has been heated in the closed corundum crucible at the temperature range of 30-1500 °C. The heating rates were varied from 2 K/min to 20 K/min. After the heat treatment, the samples have been studied by the x-ray diffraction and the electron microscopy. As one of the results of this work, it has been found that the detonation nanodiamond has not started the transition into graphite at the temperature below 800 °C.

  3. Detonation wave driven by condensation of supersaturated carbon vapor.

    Science.gov (United States)

    Emelianov, A; Eremin, A; Fortov, V; Jander, H; Makeich, A; Wagner, H Gg

    2009-03-01

    An experimental observation of a detonation wave driven by the energy of condensation of supersaturated carbon vapor is reported. The carbon vapor was formed by the thermal decay of unstable carbon suboxide C3O2 behind shock waves in mixtures containing 10-30% C3O2 in Ar. In the mixture 10% C3O2+Ar the insufficient heat release resulted in a regime of overdriven detonation. In the mixture 20% C3O2+Ar measured values of the pressure and wave velocity coincident with calculated Chapman-Jouguet parameters were attained. In the richest mixture 30% C3O2+Ar an excess heat release caused the slowing down of the condensation rate and the regime of underdriven detonation was observed.

  4. Gasdynamic characteristics of toroidal shock and detonation wave converging

    Institute of Scientific and Technical Information of China (English)

    TENG; Honghui; JIANG; Zonglin

    2005-01-01

    The modified CCW relation is applied to analyzing the shock, detonation wave converging and the role of chemical reactions in the process. Results indicate that the shock wave is strengthened faster than the detonation wave in the converging at the same initial Mach number. Euler equations implemented with a detailed chemical reaction model are solved to simulate toroidal shock and detonation wave converging. Gasdynamic characteristics of the converging are investigated, including wave interaction patterns, observable discrepancies and physical phenomena behind them. By comparing wave diffractions, converging processes and pressure evolutions in the focusing area, the different effects of chemical reactions on diffracting and converging processes are discussed and the analytic conclusion is demonstrated through the observation of numerical simulations.

  5. Velocity of detonation (VOD measurement techniques - practical approach

    Directory of Open Access Journals (Sweden)

    Aruna Dhanraj Tete

    2013-06-01

    Full Text Available Velocity of Detonation (VOD is an important measure characteristics parameter of explosive material. The performance of explosive invariably depends on the velocity of detonation. The power/ strength of explosive to cause fragmentation of the solid structure determine the efficiency of the Blast performed. It is an established fact that measuring velocity of detonation gives a good indication of the strength and hence the performance of the explosive. In this survey various VOD measurement techniques such as electric, nonelectric and fibre optic have been discussed. To aid the discussion some commercially available VOD meter comparison are also presented. After review of the existing units available commercially and study of their respective merits and demerits, feature of an ideal system is proposed. 

  6. Proceedings of the Zel’Dovich Memorial International Conference on Combustion, Detonation, Shock Waves Held in Moscow, Russia on 12-17 September 1994. Volume 2

    Science.gov (United States)

    1994-09-17

    measurements of burner inlet conditions and cold flow in furnace room. Report for Fase 1 of Project 02259. Department of Combustion Research, IsO National...investigation and practical application of detonations. A number of studies has been dedicated to diffraction of detonation waves. Gibb [1] observed the...from the convex angle. 409 ZEL’DOVICH MEMORIAL, 12-17 September 1994 References [1) Gibb A. W. PB90-221409, 1986. [21 Dick R. D. LA-UR-76-1425, 1976. [3

  7. The equation of state of predominant detonation products

    Science.gov (United States)

    Zaug, Joseph; Crowhurst, Jonathan; Bastea, Sorin; Fried, Laurence

    2009-06-01

    The equation of state of detonation products, when incorporated into an experimentally grounded thermochemical reaction algorithm can be used to predict the performance of explosives. Here we report laser based Impulsive Stimulated Light Scattering measurements of the speed of sound from a variety of polar and nonpolar detonation product supercritical fluids and mixtures. The speed of sound data are used to improve the exponential-six potentials employed within the Cheetah thermochemical code. We will discuss the improvements made to Cheetah in terms of predictions vs. measured performance data for common polymer blended explosives. Accurately computing the chemistry that occurs from reacted binder materials is one important step forward in our efforts.

  8. Can Deflagration-Detonation-Transitions occur in Type Ia Supernovae?

    CERN Document Server

    Niemeyer, J C

    1999-01-01

    The mechanism for deflagration-detonation-transition (DDT) by turbulent preconditioning, suggested to explain the possible occurrence of delayed detonations in Type Ia supernova explosions, is argued to be conceptually inconsistent. It relies crucially on diffusive heat losses of the burned material on macroscopic scales. Regardless of the amplitude of turbulent velocity fluctuations, the typical gradient scale for temperature fluctuations is shown to be the laminar flame width or smaller, rather than the factor of thousand more required for a DDT. Furthermore, thermonuclear flames cannot be fully quenched in regions much larger than the laminar flame width as a consequence of their simple ``chemistry''. Possible alternative explosion scenarios are briefly discussed.

  9. Conditional expression of type I interferon-induced bovine Mx1 GTPase in a stable transgenic vero cell line interferes with replication of vesicular stomatitis virus.

    Science.gov (United States)

    Baise, Etienne; Pire, Grégory; Leroy, Michaël; Gérardin, Joël; Goris, Nesya; De Clercq, Kris; Kerkhofs, Pierre; Desmecht, Daniel

    2004-09-01

    In some vertebrate species, type I interferon(IFN)-induced Mx gene expression has been shown to confer resistance to some single-stranded RNA (ssRNA) viruses in vitro. Because the bovine species is subject to an exceptionally wide array of infections caused by such viruses, it is anticipated that an antiviral allele should have been retained by evolution at the bovine Mx locus. The identification of such allele may help in evaluating the real significance of the Mx genotype for disease resistance in vivo, in deciphering host-virus molecular interactions involved, or in improving innate disease resistance of livestock through marker-assisted selection. We validated a double transgenic Vero cell clone in which the bovine Mx1 reference allele is placed under control of the human cytomegalovirus (CMV) enhancer-promoter sequence containing elements from the bacterial tetracycline resistance operon to regulate transcription. In the selected clone, transgene repression was very tight, and derepression by doxycycline led to homogeneous 48-h duration expression of physiologic levels of bovine Mx1. Expression of the transgene caused a dramatic decrease in cytopathic efficiency and a 500-5000-fold yield reduction of the Indiana and New Jersey serotypes of vesicular stomatitis virus (VSV). To our knowledge, the transgenic clone developed here is the first ever reported that allows conditional expression of an Mx protein, thus providing a valuable tool for studying functions of Mx proteins in general and that of bovine Mx1 in particular. This latter may henceforward be included in the group of Mx proteins with authenticated anti-VSV activity, which offers new research avenues into the field of host-virus interactions.

  10. Replicating animal mitochondrial DNA

    Directory of Open Access Journals (Sweden)

    Emily A. McKinney

    2013-01-01

    Full Text Available The field of mitochondrial DNA (mtDNA replication has been experiencing incredible progress in recent years, and yet little is certain about the mechanism(s used by animal cells to replicate this plasmid-like genome. The long-standing strand-displacement model of mammalian mtDNA replication (for which single-stranded DNA intermediates are a hallmark has been intensively challenged by a new set of data, which suggests that replication proceeds via coupled leading-and lagging-strand synthesis (resembling bacterial genome replication and/or via long stretches of RNA intermediates laid on the mtDNA lagging-strand (the so called RITOLS. The set of proteins required for mtDNA replication is small and includes the catalytic and accessory subunits of DNA polymerase y, the mtDNA helicase Twinkle, the mitochondrial single-stranded DNA-binding protein, and the mitochondrial RNA polymerase (which most likely functions as the mtDNA primase. Mutations in the genes coding for the first three proteins are associated with human diseases and premature aging, justifying the research interest in the genetic, biochemical and structural properties of the mtDNA replication machinery. Here we summarize these properties and discuss the current models of mtDNA replication in animal cells.

  11. The Initiation and Propagation of Helium Detonations in White Dwarf Envelopes

    CERN Document Server

    Shen, Ken J

    2014-01-01

    Detonations in helium-rich envelopes surrounding white dwarfs have garnered attention as triggers of faint thermonuclear ".Ia" supernovae and double detonation Type Ia supernovae. However, recent studies have found that the minimum size of a hotspot that can lead to a helium detonation is comparable to, or even larger than, the white dwarf's pressure scale height, casting doubt on the successful ignition of helium detonations in these systems. In this paper, we examine the previously neglected effects of C/O pollution and a full nuclear reaction network, and we consider hotspots with spatially constant pressure in addition to constant density hotspots. We find that the inclusion of these effects significantly decreases the minimum hotspot size for helium-rich detonation ignition, making detonations far more plausible during turbulent shell convection or during double white dwarf mergers. The increase in burning rate also decreases the minimum shell mass in which a helium detonation can successfully propagate ...

  12. Using embedded fibers to measure explosive detonation velocities

    Energy Technology Data Exchange (ETDEWEB)

    Podsednik, Jason W.; Parks, Shawn Michael; Navarro, Rudolfo J.

    2012-07-01

    Single-mode fibers were cleverly embedded into fixtures holding nitromethane, and used in conjunction with a photonic Doppler velocimeter (PDV) to measure the associated detonation velocity. These measurements have aided us in our understanding of energetic materials and enhanced our diagnostic capabilities.

  13. Detonation equation of state at LLNL, 1995. Revision 3

    Energy Technology Data Exchange (ETDEWEB)

    Souers, P.C.; Wu, B.; Haselman, L.C. Jr.

    1996-02-01

    JWL`s and 1-D Look-up tables are shown to work for ``one-track`` experiments like cylinder shots and the expanding sphere. They fail for ``many-track`` experiments like the compressed sphere. As long as the one-track experiment has dimensions larger than the explosive`s reaction zone and the explosive is near-ideal, a general JWL with R{sub 1} = 4.5 and R{sub 2} = 1.5 can be constructed, with both {omega} and E{sub o} being calculated from thermochemical codes. These general JWL`s allow comparison between various explosives plus recalculation of the JWL for different densities. The Bigplate experiment complements the cylinder test by providing continuous oblique angles of shock incidence from 0{degrees} to 70{degrees}. Explosive reaction zone lengths are determined from metal plate thicknesses, extrapolated run-to-detonation distances, radius size effects and detonation front curvature. Simple theories of the cylinder test, Bigplate, the cylinder size effect and detonation front curvature are given. The detonation front lag at the cylinder edge is shown to be proportional to the half-power of the reaction zone length. By calibrating for wall blow-out, a full set of reaction zone lengths from PETN to ANFO are obtained. The 1800--2100 K freezing effect is shown to be caused by rapid cooling of the product gases. Compiled comparative data for about 80 explosives is listed. Ten Chapters plus an Appendix.

  14. NOx Emissions from a Rotating Detonation-wave Engine

    Science.gov (United States)

    Kailasanath, Kazhikathra; Schwer, Douglas

    2016-11-01

    Rotating detonation-wave engines (RDE) are a form of continuous detonation-wave engines. They potentially provide further gains in performance than an intermittent or pulsed detonation-wave engine (PDE). The overall flow field in an idealized RDE, primarily consisting of two concentric cylinders, has been discussed in previous meetings. Because of the high pressures involved and the lack of adequate reaction mechanisms for this regime, previous simulations have typically used simplified chemistry models. However, understanding the exhaust species concentrations in propulsion devices is important for both performance considerations as well as estimating pollutant emissions. Progress towards addressing this need will be discussed in this talk. In this approach, an induction parameter model is used for simulating the detonation but a more detailed finite-chemistry model including NOx chemistry is used in the expansion flow region, where the pressures are lower and the uncertainties in the chemistry model are greatly reduced. Results show that overall radical concentrations in the exhaust flow are substantially lower than from earlier predictions with simplified models. Results to date show that NOx emissions are not a problem for the RDE due to the short residence times and the nature of the flow field. Furthermore, simulations show that the amount of NOx can be further reduced by tailoring the fluid dynamics within the RDE.

  15. Transplutonium elements processed from rock debris of underground detonations

    Science.gov (United States)

    Bloomquist, C. A. A.; Harvey, H. W.; Hoh, J. C.; Horwitz, E. P.

    1969-01-01

    Six-step chemical processing method extracts minute quantities of transplutonium elements found in rock debris following a nuclear detonation. The process consists of dissolution of rock, feed preparation, liquid-liquid extraction, final purification of transplutonium elements and plutonium, and separation of the transplutonium elements.

  16. Indirect detonation initiation using acoustic timescale thermal power deposition

    CERN Document Server

    Regele, Jonathan D; Vezolainen, Alexei; Vasilyev, Oleg V

    2012-01-01

    A fluid dynamics video is presented that demonstrates an indirect detonation initiation process. In this process, a transient power deposition adds heat to a spatially resolved volume of fluid in an amount of time that is similar to the acoustic timescale of the fluid volume. A highly resolved two-dimensional simulation shows the events that unfold after the heat is added.

  17. Cellular Structure and Oscillating Behavior of PBX Detonations

    Science.gov (United States)

    Plaksin, Igor; Rodrigues, Luis; Mendes, Ricardo; Plaksin, Svyatoslav; Ferreira, Claudia; Fernandes, Eduardo

    2015-06-01

    Efforts are aimed on experimental study of reaction localization/instabilities manifested in detonation reaction zone (DRZ) of PBXs at micro-, meso- and macro-scale. At micro- and meso-scale levels, leading role of kinetic nonequilibrium in reaction localizations onset was established in experiments with single beta-HMX crystals-in-binder subjected to 20 GPa-shock and PBX detonation. Reaction localizations and further ejecta formation were spatially resolved by 96-channel optical analyzer at simultaneous recording reaction light and stress field around crystal. Spatially resolved measurements reveal fundamental role of shear-strain in triggering initiation chemistry. At macro-scale level, formation of the cell-structures and oscillating detonation regimes revealed in HMX- and RDX-based PBXs at wide variation of grain-sizes, wt. % filler/binder, residual micro-voids and binder nature. Emphasizes placed on effect of DRZ-induced radiation upon oscillating regimes of detonation front motion. Work was supported by the ONR and ONR Global Grants N00014-12-1-0477 and N62909-12-1-7131 with Drs. Clifford Bedford and John Zimmerman Program Managers.

  18. Deflagration-to-detonation transition in granular HMX

    Science.gov (United States)

    Campbell, A. W.

    1980-01-01

    Granular HMX of three degrees of fineness was packed into heavy-walled steel tubes closed at both ends. Ignition was obtained at one end using an intimate mixture of finely divided titanium and boron as an igniter that produced heat with little gas. The distance to detonation was determined by examination of the resulting tube fragments. By inserting tightly-fitted neoprene diaphragms periodically into the HMX column, it was shown that the role of convective combustion was limited to the initial stage of the deflagration to detonation (DDT) process. Experiments in which various combinations of two of the three types of HMX were loaded into the same tube showed that heating by adiabatic shear of explosive grains was an essential factor in the final buildup to detonation. A description of the DDT process is developed in which conductive burning is followed in turn by convective burning, bed collapse with plug formation, onset of accelerated burning at the front of the plug through heating by intercrystalline friction and adiabatic shear, and intense shock formation resulting in high-order detonation.

  19. Detonation and combustion of explosives: A selected bibliography

    Energy Technology Data Exchange (ETDEWEB)

    Dobratz, B. [comp.

    1998-08-01

    This bibliography consists of citations pertinent to the subjects of combustion and detonation of energetic materials, especially, but not exclusively, of secondary solid high explosives. These references were selected from abstracting sources, conference proceedings, reviews, and also individual works. The entries are arranged alphabetically by first author and numbered sequentially. A keyword index is appended.

  20. Detonation of CHO working substances in a laser jet engine

    Science.gov (United States)

    Ageichik, A. A.; Repina, E. V.; Rezunkov, Yu. A.; Safronov, A. L.

    2009-03-01

    Laser-induced ablation of materials (including polymers and a variety of polycrystalline substances with a CHO chemical composition) is studied theoretically and experimentally. Based on experimental data, a parametric physicochemical model of detonation of these materials is put forward with the aim to estimate the efficiency of laser thrust formation in jet engines.

  1. Wave dynamic processes in cellular detonation reflection from wedges

    Institute of Scientific and Technical Information of China (English)

    Zongmin Hu; Zonglin Jiang

    2007-01-01

    When the cell width of the incident deto-nation wave (IDW) is comparable to or larger than theMach stem height,self-similarity will fail during IDWreflection from a wedge surface.In this paper,the det-onation reflection from wedges is investigated for thewave dynamic processes occurring in the wave front,including transverse shock motion and detonation cellvariations behind the Mach stem.A detailed reactionmodel is implemented to simulate two-dimensional cel-lular detonations in stoichiometric mixtures of H2/O2diluted by Argon.The numerical results show that thetransverse waves,which cross the triple point trajec-tory of Mach reflection,travel along the Mach stem andreflect back from the wedge surface,control the size ofthe cells in the region swept by the Mach stem.It is theenergy carried by these transverse waves that sustainsthe triple-wave-collision with a higher frequency withinthe over-driven Mach stem.In some cases,local wavedynamic processes and wave structures play a dominantrole in determining the pattern of cellular record,lead-ing to the fact that the cellular patterns after the Machstem exhibit some peculiar modes.

  2. Experiment of detonation characteristics of gelled gasolines in pulse detonation engine%凝胶汽油在脉冲爆轰发动机中的爆轰特性实验

    Institute of Scientific and Technical Information of China (English)

    胡洪波; 翁春生; 白桥栋; 杨建鲁

    2014-01-01

    An experimental system of pulse detonation rocket engine using gelled fuels was established to explore the feasibility of application of gelled fuels on pulse detonation engines.The hot state tests were accomplished on multi-cycle pulse detonation rock-et engine at different oxygen concentration and supply conditions of gelled fuels.The influences of oxygen concentration and fuel sup-ply conditions on pressure and wave propagation velocity of detonation wave were analyzed. The experimental results indicate that pulse detonation rocket engine can work stably with gelled fuels.With 42% oxygen in filling gases and injection pressure coefficients of fuel and atomizing air at 2.5 and 1,the average value of detonation pressure and wave velocity were 2.02 MPa and 1 124 m/s re-spectively.The pressure and wave velocity of detonation increase with oxygen addition under the same fuel supply conditions.The re-sults have some significant references for application investigation on gelled fuels and pulse detonation engines.%为探索凝胶燃料在脉冲爆轰发动机中应用的可行性,设计了凝胶汽油脉冲爆轰火箭发动机实验系统。对不同氧含量和凝胶汽油供给工况下的多循环脉冲爆轰发动机进行了热态实验,分析了氧含量和燃料供给工况对爆轰段爆轰压力和波传播速度的影响。实验结果表明,使用凝胶汽油的脉冲爆轰火箭发动机能稳定工作;在氧气质量百分比为42%、凝胶汽油/雾化空气喷射压力系数为2.5/1工况下,距离发动机点火位置770 mm处的爆轰压力均值为2.02 MPa,爆轰波速度均值为1124 m/s。在相同凝胶汽油供给条件下,增加氧含量能够获得更大的爆轰压力和爆轰波速度。研究结果对凝胶燃料和脉冲爆轰发动机应用研究具有参考意义。

  3. The Replication Recipe: What makes for a convincing replication?

    NARCIS (Netherlands)

    Brandt, M.J.; IJzerman, H.; Dijksterhuis, A.J.; Farach, F.J.; Geller, J.; Giner-Sorolla, R.; Grange, J.A.; Perugini, M.; Spies, J.R.; Veer, A. van 't

    2014-01-01

    Psychological scientists have recently started to reconsider the importance of close replications in building a cumulative knowledge base; however, there is no consensus about what constitutes a convincing close replication study. To facilitate convincing close replication attempts we have developed

  4. No double detonations but core carbon ignitions in high-resolution, grid-based simulations of binary white dwarf mergers

    Science.gov (United States)

    Fenn, D.; Plewa, T.; Gawryszczak, A.

    2016-11-01

    We study the violent phase of the merger of massive binary white dwarf systems. Our aim is to characterize the conditions for explosive burning to occur, and identify a possible explosion mechanism of Type Ia supernovae. The primary components of our model systems are carbon-oxygen (C/O) white dwarfs, while the secondaries are made either of C/O or of pure helium. We account for tidal effects in the initial conditions in a self-consistent way, and consider initially well-separated systems with slow inspiral rates. We study the merger evolution using an adaptive mesh refinement, reactive, Eulerian code in three dimensions, assuming symmetry across the orbital plane. We use a corotating reference frame to minimize the effects of numerical diffusion, and solve for self-gravity using a multigrid approach. We find a novel detonation mechanism in C/O mergers with massive primaries. Here, the detonation occurs in the primary's core and relies on the combined action of tidal heating, accretion heating, and self-heating due to nuclear burning. The exploding structure is compositionally stratified, with a reverse shock formed at the surface of the dense ejecta. The existence of such a shock has not been reported elsewhere. The explosion energy (1.6 × 1051 erg) and 56Ni mass (0.86 M⊙) are consistent with an SN Ia at the bright end of the luminosity distribution, with an approximated decline rate of Δm15(B) ≈ 0.99. Our study does not support double-detonation scenarios in the case of a system with a 0.6 M⊙ helium secondary and a 0.9 M⊙ primary. Although the accreted helium detonates, it fails to ignite carbon at the base of the boundary layer or in the primary's core.

  5. Modeling DNA Replication.

    Science.gov (United States)

    Bennett, Joan

    1998-01-01

    Recommends the use of a model of DNA made out of Velcro to help students visualize the steps of DNA replication. Includes a materials list, construction directions, and details of the demonstration using the model parts. (DDR)

  6. Eukaryotic DNA Replication Fork.

    Science.gov (United States)

    Burgers, Peter M J; Kunkel, Thomas A

    2017-06-20

    This review focuses on the biogenesis and composition of the eukaryotic DNA replication fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the lagging strand of the replication fork. Physical and genetic methodologies aimed at understanding these processes are discussed. The preponderance of evidence supports a model in which DNA polymerase ε (Pol ε) carries out the bulk of leading strand DNA synthesis at an undisturbed replication fork. DNA polymerases α and δ carry out the initiation of Okazaki fragment synthesis and its elongation and maturation, respectively. This review also discusses alternative proposals, including cellular processes during which alternative forks may be utilized, and new biochemical studies with purified proteins that are aimed at reconstituting leading and lagging strand DNA synthesis separately and as an integrated replication fork.

  7. The combustion-deflagration-detonation transition: experimental study and modeling; Transition combustion-deflagration-detonation: etude experimentale et modelisation

    Energy Technology Data Exchange (ETDEWEB)

    Lemoine, D.; Belmas, R. [CEA Le Ripault, 37 - Tours (France)

    1996-12-31

    The results of specific thermal tests performed on a pressed octogene-based explosive compound allow to identify the physical mechanisms which govern the combustion-deflagration-detonation transition process in this compound. A simple and efficient modeling of these phenomena is proposed. (J.S.)

  8. Abiotic self-replication.

    Science.gov (United States)

    Meyer, Adam J; Ellefson, Jared W; Ellington, Andrew D

    2012-12-18

    The key to the origins of life is the replication of information. Linear polymers such as nucleic acids that both carry information and can be replicated are currently what we consider to be the basis of living systems. However, these two properties are not necessarily coupled. The ability to mutate in a discrete or quantized way, without frequent reversion, may be an additional requirement for Darwinian evolution, in which case the notion that Darwinian evolution defines life may be less of a tautology than previously thought. In this Account, we examine a variety of in vitro systems of increasing complexity, from simple chemical replicators up to complex systems based on in vitro transcription and translation. Comparing and contrasting these systems provides an interesting window onto the molecular origins of life. For nucleic acids, the story likely begins with simple chemical replication, perhaps of the form A + B → T, in which T serves as a template for the joining of A and B. Molecular variants capable of faster replication would come to dominate a population, and the development of cycles in which templates could foster one another's replication would have led to increasingly complex replicators and from thence to the initial genomes. The initial genomes may have been propagated by RNA replicases, ribozymes capable of joining oligonucleotides and eventually polymerizing mononucleotide substrates. As ribozymes were added to the genome to fill gaps in the chemistry necessary for replication, the backbone of a putative RNA world would have emerged. It is likely that such replicators would have been plagued by molecular parasites, which would have been passively replicated by the RNA world machinery without contributing to it. These molecular parasites would have been a major driver for the development of compartmentalization/cellularization, as more robust compartments could have outcompeted parasite-ridden compartments. The eventual outsourcing of metabolic

  9. Adenovirus DNA Replication

    OpenAIRE

    Hoeben, Rob C.; Uil, Taco G.

    2013-01-01

    Adenoviruses have attracted much attention as probes to study biological processes such as DNA replication, transcription, splicing, and cellular transformation. More recently these viruses have been used as gene-transfer vectors and oncolytic agents. On the other hand, adenoviruses are notorious pathogens in people with compromised immune functions. This article will briefly summarize the basic replication strategy of adenoviruses and the key proteins involved and will deal with the new deve...

  10. conditions

    Directory of Open Access Journals (Sweden)

    M. Venkatesulu

    1996-01-01

    Full Text Available Solutions of initial value problems associated with a pair of ordinary differential systems (L1,L2 defined on two adjacent intervals I1 and I2 and satisfying certain interface-spatial conditions at the common end (interface point are studied.

  11. Experimental investigations on the power extraction of a turbine driven by a pulse detonation combustor

    Institute of Scientific and Technical Information of China (English)

    Li Xiaofeng; Zheng Longxi; Qiu Hua; Chen Jingbin

    2013-01-01

    In order to grasp the interaction mechanism between the pulse detonation combustor (PDC) and the turbine, the experimental work in this paper investigates the key factors on the power extraction of a turbocharger turbine driven by a PDC. A PDC consisting of an unvalved tube is integrated with a turbocharger turbine which has a nominal mass flow rate of 0.6 kg/s and 50000 r/min. The PDC-turbine hybrid engine is operated on gasoline-air mixtures and runs for 6+min to achieve a thermal steady state, and then the engine performance is evaluated under dif-ferent operating conditions. Results show that the momentum difference per unit area between the turbine inlet and outlet plays an important role in the power extraction, while the pressure peak of the detonation has little effect. The equivalence ratio of fuel and air mixture and the transition structure between PDC and turbine are also important to the power extraction of the turbine. The present work is promising as it suggests that the performance benefit of a PDC-turbine hybrid engine can be realized by increasing the momentum difference per unit area through the optimal design of transition section between the PDC and turbine.

  12. Numerical prediction of oblique detonation wave structures using detailed and reduced reaction mechanisms

    Science.gov (United States)

    Thaker, A. A.; Chelliah, H. K.

    1997-12-01

    Modelling of the structure and the limiting flow turning angles of an oblique detonation wave, established by a two-dimensional wedge, requires the implementation of detailed chemical kinetic models involving a large number of chemical species. In this paper, a method of reducing the computational effort involved in simulating such high-speed reacting flows by implementing a systematically reduced reaction mechanism is presented. For a hydrogen - air mixture, starting with an elementary mechanism having eight species in 12 reactions, three alternate four-step reduced reaction mechanisms are developed by introducing the steady-state approximation for the reaction intermediates HO2, O and OH, respectively. Additional reduction of the computational effort is achieved by introducing simplifications to the thermochemical data evaluations. The influence of the numerical grid used in predicting the induction process behind the shock is also investigated. Comparisons of the induction zone predicted by two-dimensional oblique detonation wave calculations with that of a static reactor model (with initial conditions of the gas mixture specified by those behind the nonreactive oblique shock wave) are also presented. The reasonably good agreement between the three four-step reduced mechanism predictions and the starting mechanism predictions indicates that further reduction to a two-step mechanism is feasible for the physical flow time scales (corresponding to inflow Mach numbers of 8 - 10) considered here, and needs to be pursued in the future.

  13. On the resonant detonation of sub-Chandrasekhar mass white dwarfs during binary inspiral

    CERN Document Server

    McKernan, B

    2016-01-01

    White dwarfs (WDs) are believed to detonate via explosive Carbon-fusion in a Type Ia Supernova when their temperature and/or density reach the point where Carbon is ignited in a runaway reaction. Observations of the Type Ia supernova (SN) rate imply all WD binaries that merge through the emission of gravitational radiation within a Hubble time should result in SNe, regardless of total mass. Here we investigate the conditions under which a single WD in a binary system might extract energy from its orbit, depositing enough energy into a resonant mode such that it detonates before merger. We show that, ignoring non-linear effects, in a WD binary in tidal lock at small binary separations, the sustained tidal forcing of a low-order quadrupolar g-mode or a harmonic of a low-order quadrupolar p-mode could in principle drive the average temperature of Carbon nuclei in the mode over the runaway fusion threshold. If growing mode energy is thermalized at a core/atmosphere boundary, rapid Helium burning and inward-travel...

  14. Construction of conditionally replicative adenovirus vector mediated by dual specific promoters%双特异性启动子调控条件复制腺病毒载体的构建

    Institute of Scientific and Technical Information of China (English)

    李玮; 谭建

    2013-01-01

    Objective To construct and identify the conditionally replicative adenovirus vectors which may induce the human sodium iodide symporter (hNIS) expression in the early region 1A (E1A) gene of the human telomerase reverse transcriptase (hTERT) and the glial fibrillary acidic protein (GFAP)promoter regions.Methods Immunoblotting assay was employed to detect the variation in GFAP and telomerase protein expression prior to and following viral infection of the cerebral stellar glioblastoma cells (U87),neuroglioma cells (U251) and human embryonic lung fibroblasts (MRC-5) cells.The hTERT and GFAP promoters and the hNIS genes were amplified by polymerase chain reaction for synthesis of adenoviral E1A genes.The recombinant plasmids containing hTERT and GFAP gene promoters were adopted for transfection into MRC-5,U251 and U87,which entailed assessment of the hTERT and GFAP promoter activity via fluorescent analysis after 24 h.This was followed by ligation with the E1A and hNIS genes and subsequent cloning into the plasmid pDC311 for construction of the recombinant plasmid pDC311-Tp-E1A-Gp-NIS that was identified by double enzyme digestion (EcoR Ⅰ and Sal Ⅰ) and gene sequencing.This recombinant plasmid was co-transfected with adenoviral genomic plasmid pBHGlox△E1-3Cre into the human embryonic kidney 293 cells forming the conditionally replicative recombinant adenovirus Ad-Tp-E1A-Gp-NIS.This Ad-Tp-E1A-Gp-NIS was employed to transfect the 293,MRC-5,U87 and U251 cells,whose conditional replicability was measured by plaque forming assay.The recombinant virus Ad-Tp-E1A-Gp-NIS and Ad-CMV-EGFP controls were used to transfect the U251,U87 and MRC-5 cells for detection of the capacity of 125I uptake by using a γ-ray counter.Results The expression of the 120 000 telomerase and 49 000 GFAP protein could be found in U87 and U251 cells,but not in MRC-5 cells.Glioma target gene expression could be induced by the GFAP and hTERT promoters,the efficiency of which was (62.10±6.26)

  15. Investigating variation in replicability: A "Many Labs" replication project

    NARCIS (Netherlands)

    Klein, R.A.; Ratliff, K.A.; Vianello, M.; Adams, R.B.; Bahnik, S.; Bernstein, M.J.; Bocian, K.; Brandt, M.J.; Brooks, B.; Brumbaugh, C.C.; Cemalcilar, Z.; Chandler, J.; Cheong, W.; Davis, W.E.; Devos, T.; Eisner, M.; Frankowska, N.; Furrow, D.; Galliani, E.M.; Hasselman, F.W.; Hicks, J.A.; Hovermale, J.F.; Hunt, S.J.; Huntsinger, J.R.; IJzerman, H.; John, M.S.; Joy-Gaba, J.A.; Kappes, H.B.; Krueger, L.E.; Kurtz, J.; Levitan, C.A.; Mallett, R.K.; Morris, W.L.; Nelson, A.J.; Nier, J.A.; Packard, G.; Pilati, R.; Rutchick, A.M.; Schmidt, K.; Skorinko, J.L.M.; Smith, R.; Steiner, T.G.; Storbeck, J.; Van Swol, L.M.; Thompson, D.; Veer, A.E. van 't; Vaughn, L.A.; Vranka, M.; Wichman, A.L.; Woodzicka, J.A.; Nosek, B.A.

    2014-01-01

    Although replication is a central tenet of science, direct replications are rare in psychology. This research tested variation in the replicability of 13 classic and contemporary effects across 36 independent samples totaling 6,344 participants. In the aggregate, 10 effects replicated consistently.

  16. Hepatitis B virus replication

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Hepadnaviruses, including human hepatitis B virus (HBV), replicate through reverse transcription of an RNA intermediate, the pregenomic RNA (pgRNA). Despite this kinship to retroviruses, there are fundamental differences beyond the fact that hepadnavirions contain DNA instead of RNA. Most peculiar is the initiation of reverse transcription: it occurs by protein-priming, is strictly committed to using an RNA hairpin on the pgRNA,ε, as template, and depends on cellular chaperones;moreover, proper replication can apparently occur only in the specialized environment of intact nucleocapsids.This complexity has hampered an in-depth mechanistic understanding. The recent successful reconstitution in the test tube of active replication initiation complexes from purified components, for duck HBV (DHBV),now allows for the analysis of the biochemistry of hepadnaviral replication at the molecular level. Here we review the current state of knowledge at all steps of the hepadnaviral genome replication cycle, with emphasis on new insights that turned up by the use of such cellfree systems. At this time, they can, unfortunately,not be complemented by three-dimensional structural information on the involved components. However, at least for the s RNA element such information is emerging,raising expectations that combining biophysics with biochemistry and genetics will soon provide a powerful integrated approach for solving the many outstanding questions. The ultimate, though most challenging goal,will be to visualize the hepadnaviral reverse transcriptase in the act of synthesizing DNA, which will also have strong implications for drug development.

  17. Psychology, replication & beyond.

    Science.gov (United States)

    Laws, Keith R

    2016-06-01

    Modern psychology is apparently in crisis and the prevailing view is that this partly reflects an inability to replicate past findings. If a crisis does exists, then it is some kind of 'chronic' crisis, as psychologists have been censuring themselves over replicability for decades. While the debate in psychology is not new, the lack of progress across the decades is disappointing. Recently though, we have seen a veritable surfeit of debate alongside multiple orchestrated and well-publicised replication initiatives. The spotlight is being shone on certain areas and although not everyone agrees on how we should interpret the outcomes, the debate is happening and impassioned. The issue of reproducibility occupies a central place in our whig history of psychology.

  18. Set-valued solutions for non-ideal detonation

    KAUST Repository

    Semenko, Roman

    2015-12-11

    The existence and structure of a steady-state gaseous detonation propagating in a packed bed of solid inert particles are analyzed in the one-dimensional approximation by taking into consideration frictional and heat losses between the gas and the particles. A new formulation of the governing equations is introduced that eliminates the difficulties with numerical integration across the sonic singularity in the reactive Euler equations. With the new algorithm, we find that when the sonic point disappears from the flow, there exists a one-parameter family of solutions parameterized by either pressure or temperature at the end of the reaction zone. These solutions (termed “set-valued” here) correspond to a continuous spectrum of the eigenvalue problem that determines the detonation velocity as a function of a loss factor.

  19. Study of a model equation in detonation theory: multidimensional effects

    CERN Document Server

    Faria, Luiz M; Rosales, Rodolfo R

    2015-01-01

    We extend the reactive Burgers equation presented in Kasimov et al. Phys. Rev. Lett., 110 (2013) and Faria et al. SIAM J. Appl. Maths, 74 (2014), to include multidimensional effects. Furthermore, we explain how the model can be rationally justified following the ideas of the asymptotic theory developed in Faria et al. JFM (2015). The proposed model is a forced version of the unsteady small disturbance transonic flow equations. We show that for physically reasonable choices of forcing functions, traveling wave solutions akin to detonation waves exist. It is demonstrated that multidimensional effects play an important role in the stability and dynamics of the traveling waves. Numerical simulations indicate that solutions of the model tend to form multi-dimensional patterns analogous to cells in gaseous detonations.

  20. Study of a Model Equation in Detonation Theory

    KAUST Repository

    Faria, Luiz

    2014-04-24

    Here we analyze properties of an equation that we previously proposed to model the dynamics of unstable detonation waves [A. R. Kasimov, L. M. Faria, and R. R. Rosales, Model for shock wave chaos, Phys. Rev. Lett., 110 (2013), 104104]. The equation is ut+ 1/2 (u2-uu (0-, t))x=f (x, u (0-, t)), x > 0, t < 0. It describes a detonation shock at x = 0 with the reaction zone in x > 0. We investigate the nature of the steady-state solutions of this nonlocal hyperbolic balance law, the linear stability of these solutions, and the nonlinear dynamics. We establish the existence of instability followed by a cascade of period-doubling bifurcations leading to chaos. © 2014 Society for Industrial and Applied Mathematics.

  1. CIRCUMSTELLAR ABSORPTION IN DOUBLE DETONATION TYPE Ia SUPERNOVAE

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Ken J. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Guillochon, James [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Foley, Ryan J., E-mail: kenshen@astro.berkeley.edu [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States)

    2013-06-20

    Upon formation, degenerate He core white dwarfs are surrounded by a radiative H-rich layer primarily supported by ideal gas pressure. In this Letter, we examine the effect of this H-rich layer on mass transfer in He+C/O double white dwarf binaries that will eventually merge and possibly yield a Type Ia supernova (SN Ia) in the double detonation scenario. Because its thermal profile and equation of state differ from the underlying He core, the H-rich layer is transferred stably onto the C/O white dwarf prior to the He core's tidal disruption. We find that this material is ejected from the binary system and sweeps up the surrounding interstellar medium hundreds to thousands of years before the SN Ia. The close match between the resulting circumstellar medium profiles and values inferred from recent observations of circumstellar absorption in SNe Ia gives further credence to the resurgent double detonation scenario.

  2. Ground-based Nuclear Detonation Detection (GNDD) Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Casey, Leslie A.

    2014-01-13

    This GNDD Technology Roadmap is intended to provide guidance to potential researchers and help management define research priorities to achieve technology advancements for ground-based nuclear explosion monitoring science being pursued by the Ground-based Nuclear Detonation Detection (GNDD) Team within the Office of Nuclear Detonation Detection in the National Nuclear Security Administration (NNSA) of the U.S. Department of Energy (DOE). Four science-based elements were selected to encompass the entire scope of nuclear monitoring research and development (R&D) necessary to facilitate breakthrough scientific results, as well as deliver impactful products. Promising future R&D is delineated including dual use associated with the Comprehensive Nuclear-Test-Ban Treaty (CTBT). Important research themes as well as associated metrics are identified along with a progression of accomplishments, represented by a selected bibliography, that are precursors to major improvements to nuclear explosion monitoring.

  3. Performance Impact of Deflagration to Detonation Transition Enhancing Obstacles

    Science.gov (United States)

    Paxson, Daniel E.; Schauer, Frederick; Hopper, David

    2012-01-01

    A sub-model is developed to account for the drag and heat transfer enhancement resulting from deflagration-to-detonation (DDT) inducing obstacles commonly used in pulse detonation engines (PDE). The sub-model is incorporated as a source term in a time-accurate, quasi-onedimensional, CFD-based PDE simulation. The simulation and sub-model are then validated through comparison with a particular experiment in which limited DDT obstacle parameters were varied. The simulation is then used to examine the relative contributions from drag and heat transfer to the reduced thrust which is observed. It is found that heat transfer is far more significant than aerodynamic drag in this particular experiment.

  4. Engineering models of deflagration-to-detonation transition

    Energy Technology Data Exchange (ETDEWEB)

    Bdzil, J.B.; Son, S.F.

    1995-07-01

    For the past two years, Los Alamos has supported research into the deflagration-to-detonation transition (DDT) in damaged energetic materials as part of the explosives safety program. This program supported both a theory/modeling group and an experimentation group. The goal of the theory/modeling group was to examine the various modeling structures (one-phase models, two-phase models, etc.) and select from these a structure suitable to model accidental initiation of detonation in damaged explosives. The experimental data on low-velocity piston supported DDT in granular explosive was to serve as a test bed to help in the selection process. Three theoretical models have been examined in the course of this study: (1) the Baer-Nunziato (BN) model, (2) the Stewart-Prasad-Asay (SPA) model and (3) the Bdzil-Kapila-Stewart model. Here we describe these models, discuss their properties, and compare their features.

  5. Munitions having an insensitive detonator system for initiating large failure diameter explosives

    Science.gov (United States)

    Perry, III, William Leroy

    2015-08-04

    A munition according to a preferred embodiment can include a detonator system having a detonator that is selectively coupled to a microwave source that functions to selectively prime, activate, initiate, and/or sensitize an insensitive explosive material for detonation. The preferred detonator can include an explosive cavity having a barrier within which an insensitive explosive material is disposed and a waveguide coupled to the explosive cavity. The preferred system can further include a microwave source coupled to the waveguide such that microwaves enter the explosive cavity and impinge on the insensitive explosive material to sensitize the explosive material for detonation. In use the preferred embodiments permit the deployment and use of munitions that are maintained in an insensitive state until the actual time of use, thereby substantially preventing unauthorized or unintended detonation thereof.

  6. Effect of chemical reactivity on the detonation initiation in shock accelerated flow in a confined space

    Institute of Scientific and Technical Information of China (English)

    Yue-Jin Zhu; Gang Dong; Yi-Xin Liu; Bao-Chun Fan; Hua Jiang

    2013-01-01

    The interactions of a spherical flame with an incident shock wave and its reflected shock wave in a confined space were investigated using the three-dimensional reactive Navier-Stokes equations,with emphasis placed on the effect of chemical reactivity of mixture on the flame distortion and detonation initiation after the passage of the reflected shock wave.It is shown that the spatio-temporal characteristics of detonation initiation depend highly on the chemical reactivity of the mixture.When the chemical reactivity enhances,the flame can be severely distorted to form a reactive shock bifurcation structure with detonations initiating at different three-dimensional spatial locations.Moreover,the detonation initiation would occur earlier in a mixture of more enhanced reactivity.The results reveal that the detonations arise from hot spots in the unburned region which are initiated by the shock-detonation-transition mechanism.

  7. Multi-frame visualization for detonation wave diffraction

    Science.gov (United States)

    Nagura, Y.; Kasahara, J.; Matsuo, A.

    2016-09-01

    When a detonation wave emerges from a tube into unconfined space filled with a gas mixture, detonation wave diffraction occurs due to abrupt changes in the cross-sectional area. In the present study, we focused on the local explosion in reinitiation and propagation of a transverse detonation wave by performing comprehensive and direct observation with high time resolution visualization in a two-dimensional rectangular channel. Using the visualization methods of shadowgraph and multi-frame, short-time, open-shutter photography, we determined where the wall reflection point is generated, and also determined where the bright point is originated by the local explosion, and investigated the effects of the deviation angle and initial pressure of the gas mixture. We found that the reinitiation of detonation had two modes that were determined by the deviation angle of the channel. If the deviation angle was less than or equal to 30°, the local explosion of reinitiation might occur in the vicinity of the channel wall, and if the deviation angle was greater than or equal to 60°, the local explosion might originate on the upper side of the tube exit. With a deviation angle greater than 60°, the position of the wall reflection point depended on the cell width, so the radial distance of the wall reflection point from the apex of the tube exit was about 12 times the cell width. Similarly, the bright point (local explosion point) was located a distance of about 11 times the cell width from the apex of the tube exit, with a circumferential angle of 48°.

  8. Set-valued solutions for non-ideal detonation

    OpenAIRE

    Semenko, Roman; Faria, Luiz; Kasimov, Aslan; Ermolaev, Boris

    2013-01-01

    The existence and structure of steady gaseous detonation propagating in a packed bed of solid inert particles are analyzed in the one-dimensional approximation by taking into consideration frictional and heat losses between the gas and the particles. A new formulation of the governing equations is introduced that eliminates the well-known difficulties with numerical integration across the sonic singularity in the reactive Euler equations. The new algorithm allows us to determine that the deto...

  9. Three Dimensional Analysis of Induced Detonation of Cased Explosive

    Science.gov (United States)

    2014-10-16

    armour (RHA) steel were investigated through the LS-DYNA. The investigation focused on shock to detonation simulations of Composition B, with the...Cook Constitutive Material Model (RHA-Steel) The encasing structure was made from Rolled Homogenous Armour (RHA) steel. The face of the steel was...steel. Rolling also elongates the grain structure in the steel to form long lines, which enables the stress under which the steel was placed to flow

  10. Publicly Released Prompt Radiation Spectra Suitable for Nuclear Detonation Simulations

    Science.gov (United States)

    2017-03-01

    emission. During the Hiroshima and Nagasaki bombings, the prompt radiation contributed from 40%-70% of the free-in-air dose depending on distance from...intermediate- and low -yield thermonuclear weapons for initial radiation shielding calculations No Gritzner, et al. 1976 (EM-1, Low , Henre...Publicly Released Prompt Radiation Spectra Suitable for Nuclear Detonation Simulations DISTRIBUTION A. Approved for public release; distribution is

  11. Application of the Modified Compaction Material Model to the Analysis of Landmine Detonation in Soil with Various Degrees of Water Saturation

    Directory of Open Access Journals (Sweden)

    M. Grujicic

    2008-01-01

    Full Text Available A series of transient non-linear dynamics computational analyses of the explosion phenomena accompanying the detonation of a 100g C4 mine buried in sand to different depths is carried out using the software package AUTODYN. The mechanical response of sand under high deformation-rate conditions has been represented using the modified compaction material model developed in our recent work [1]. While the mechanical response of the other attendant materials (air, gaseous-detonation products and AISI 1006 mild steel is accounted for using the material models available in literature. The results obtained (specifically, the temporal evolution of the sand overburden shape and pressure at various locations in air above the detonation site were compared with their experimental counterparts for a (50wt%-sand/50wt.%-clay soil obtained recently by Foedinger [2]. The comparison revealed that the modified compaction material model for sand can account reasonably well for the magnitude, spatial distribution and the temporal evolution of the dynamic loads accompanying detonation of shallow-buried mines in soils with various clay and water contents.

  12. On the propagation mechanism of a detonation wave in a round tube with orifice plates

    Science.gov (United States)

    Ciccarelli, G.; Cross, M.

    2016-09-01

    This study deals with the investigation of the detonation propagation mechanism in a circular tube with orifice plates. Experiments were performed with hydrogen air in a 10-cm-inner-diameter tube with the second half of the tube filled with equally spaced orifice plates. A self-sustained Chapman-Jouguet (CJ) detonation wave was initiated in the smooth first half of the tube and transmitted into the orifice-plate-laden second half of the tube. The details of the propagation were obtained using the soot-foil technique. Two types of foils were used between obstacles, a wall-foil placed on the tube wall, and a flat-foil (sooted on both sides) placed horizontally across the diameter of the tube. When placed after the first orifice plate, the flat foil shows symmetric detonation wave diffraction and failure, while the wall foil shows re-initiation via multiple local hot spots created when the decoupled shock wave interacts with the tube wall. At the end of the tube, where the detonation propagated at an average velocity much lower than the theoretical CJ value, the detonation propagation is much more asymmetric with only a few hot spots on the tube wall leading to local detonation initiation. Consecutive foils also show that the detonation structure changes after each obstacle interaction. For a mixture near the detonation propagation limit, detonation re-initiation occurs at a single wall hot spot producing a patch of small detonation cells. The local overdriven detonation wave is short lived, but is sufficient to keep the global explosion front propagating. Results associated with the effect of orifice plate blockage and spacing on the detonation propagation mechanism are also presented.

  13. Radiation Injury After a Nuclear Detonation: Medical Consequences and the Need for Scarce Resources Allocation

    OpenAIRE

    DiCarlo, Andrea L.; Maher, Carmen; Hick, John L.; Hanfling, Dan; Dainiak, Nicholas; Chao, Nelson; Bader, Judith L.; Coleman, C. Norman; Weinstock, David M.

    2011-01-01

    A 10-kiloton (kT) nuclear detonation within a US city could expose hundreds of thousands of people to radiation. The Scarce Resources for a Nuclear Detonation Project was undertaken to guide community planning and response in the aftermath of a nuclear detonation, when demand will greatly exceed available resources. This article reviews the pertinent literature on radiation injuries from human exposures and animal models to provide a foundation for the triage and management approaches outline...

  14. The role of multidimensional instabilities in direct initiation of gaseous detonations in free space

    KAUST Repository

    Shen, Hua

    2017-01-20

    We numerically investigate the direct initiation of detonations driven by the propagation of a blast wave into a unconfined gaseous combustible mixture to study the role played by multidimensional instabilities in direct initiation of stable and unstable detonations. To this end, we first model the dynamics of unsteady propagation of detonation using the one-dimensional compressible Euler equations with a one-step chemical reaction model and cylindrical geometrical source terms. Subsequently, we use two-dimensional compressible Euler equations with just the chemical reaction source term to directly model cylindrical detonations. The one-dimensional results suggest that there are three regimes in the direct initiation for stable detonations, that the critical energy for mildly unstable detonations is not unique, and that highly unstable detonations are not self-sustainable. These phenomena agree well with one-dimensional theories and computations available in the literature. However, our two-dimensional results indicate that one-dimensional approaches are valid only for stable detonations. In mildly and highly unstable detonations, one-dimensional approaches break down because they cannot take the effects and interactions of multidimensional instabilities into account. In fact, instabilities generated in multidimensional settings yield the formation of strong transverse waves that, on one hand, increase the risk of failure of the detonation and, on the other hand, lead to the initiation of local over-driven detonations that enhance the overall self-sustainability of the global process. The competition between these two possible outcomes plays an important role in the direct initiation of detonations.

  15. Volumetric initiation of gaseous detonation by radiant heating of suspended microparticles

    Science.gov (United States)

    Efremov, V. P.; Ivanov, M. F.; Kiverin, A. D.; Yakovenko, I. S.

    2016-02-01

    The concept of detonation wave initiation in the local volume of a fuel-gas mixture containing suspended chemically neutral microparticles heated by radiant energy from an external source is proposed. Mechanisms of initiation of the combustion and detonation waves in a region of accumulation of the radiation- heated microparticles have been studied by numerical simulation methods. Criteria that determine geometric dimensions of a region of the two-phase medium, which are necessary for the initiation of detonation waves, are formulated.

  16. Cavity Ignition in Supersonic Flow by Spark Discharge and Pulse Detonation

    Science.gov (United States)

    2014-08-18

    constant volume, through a detonation , or some combination. While a deflagration (flame) through constant volume combustion can provide rapid heat release...significantly disrupted, and the detonation was able to ignite and burn most of the fuel within the cavity. This led to decreased heat release in regime IV...locate/proci of the Combustion InstituteCavity ignition in supersonic flow by spark discharge and pulse detonation Timothy M. Ombrello a,⇑, Campbell D

  17. Classification of Battlespace Detonations from Temporally Resolved Multi-Band Imagery and Mid-Infrared Spectra

    Science.gov (United States)

    2005-03-01

    called the heat of detonation and includes only the combustion of the explosive reactants, not the heat associated with the secondary afterburn. This...32:24] 2. Basic Phenomenology As mentioned earlier, the heat of detonation ∆H is the heat (or energy) generated during the reaction and is...232, −++++= eTdTcTbTaTC ip , (5) where the coefficients a through e are defined in Table 2, the heat of detonation becomes an integral

  18. Effect of Mixture Pressure and Equivalence Ratio on Detonation Cell Size for Hydrogen-Air Mixtures

    Science.gov (United States)

    2015-06-01

    EFFECT OF MIXTURE PRESSURE AND EQUIVALENCE RATIO ON DETONATION CELL SIZE FOR HYDROGEN -AIR MIXTURES...protection in the United States. AFIT-ENY-MS-15-J-045 EFFECT OF MIXTURE PRESSURE AND EQUIVALENCE RATIO ON DETONATION CELL SIZE FOR HYDROGEN -AIR...DISTRIBUTION UNLIMITED. AFIT-ENY-MS-15-J-045 EFFECT OF MIXTURE PRESSURE AND EQUIVALENCE RATIO ON DETONATION CELL SIZE FOR HYDROGEN -AIR MIXTURES

  19. Shock and Detonation Physics at Los Alamos National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Robbins, David L [Los Alamos National Laboratory; Dattelbaum, Dana M [Los Alamos National Laboratory; Sheffield, Steve A [Los Alamos National Laboratory

    2012-08-22

    WX-9 serves the Laboratory and the Nation by delivering quality technical results, serving customers that include the Nuclear Weapons Program (DOE/NNSA), the Department of Defense, the Department of Homeland Security and other government agencies. The scientific expertise of the group encompasses equations-of-state, shock compression science, phase transformations, detonation physics including explosives initiation, detonation propagation, and reaction rates, spectroscopic methods and velocimetry, and detonation and equation-of-state theory. We are also internationally-recognized in ultra-fast laser shock methods and associated diagnostics, and are active in the area of ultra-sensitive explosives detection. The facility capital enabling the group to fulfill its missions include a number of laser systems, both for laser-driven shocks, and spectroscopic analysis, high pressure gas-driven guns and powder guns for high velocity plate impact experiments, explosively-driven techniques, static high pressure devices including diamond anvil cells and dilatometers coupled with spectroscopic probes, and machine shops and target fabrication facilities.

  20. Equations of state of detonation products: ammonia and methane

    Science.gov (United States)

    Lang, John; Dattelbaum, Dana; Goodwin, Peter; Garcia, Daniel; Coe, Joshua; Leiding, Jeffery; Gibson, Lloyd; Bartram, Brian

    2015-06-01

    Ammonia (NH3) and methane (CH4) are two principal product gases resulting from explosives detonation, and the decomposition of other organic materials under shockwave loading (such as foams). Accurate thermodynamic descriptions of these gases are important for understanding the detonation performance of high explosives. However, shock compression data often do not exist for molecular species in the dense gas phase, and are limited in the fluid phase. Here, we present equation of state measurements of elevated initial density ammonia and methane gases dynamically compressed in gas-gun driven plate impact experiments. Pressure and density of the shocked gases on the principal Hugoniot were determined from direct particle velocity and shock wave velocity measurements recorded using optical velocimetry (Photonic Doppler velocimetry (PDV) and VISAR (velocity interferometer system for any reflector)). Streak spectroscopy and 5-color pyrometry were further used to measure the emission from the shocked gases, from which the temperatures of the shocked gases were estimated. Up to 0.07 GPa, ammonia was not observed to ionize, with temperature remaining below 7000 K. These results provide quantitative measurements of the Hugoniot locus for improving equations of state models of detonation products.

  1. Projected Response of Typical Detonators to Electrostatic Discharge (ESD) Environments

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, M J

    2002-12-20

    The purpose of this discussion is to indicate the threshold values for low-order detonator response by using first principles applied to pin-to-pin configurations and associated limits in pin-to-case scenarios. In addition an attempt to define the electrical environment by first principles is shown to be inadequate and indicates the need to define the electrical insult by reasonable standards. A comparison of two accepted electrical models and a combination of the extreme reported levels from both standards are used to establish an extreme set of parameters for a safety assessment. A simplification of the critical electrical insult parameters is then shown and demonstrated to provide the initial screening protocol with easily defined electrical dimensions of action integral. Action integral and the conductive material properties are the basic parameters needed to define the solid, liquid, and gas phases of the material used for detonator bridge wires. The resulting material phases are directly related to detonator response thresholds. The discussion concludes by showing the ability of ESD insults to arc from pin-to-case, the limited knowledge of the associated arc initiation process, and the modeling need for a reasonable arc resistance in pin-to-case scenarios.

  2. Energy Loss in Pulse Detonation Engine due to Fuel Viscosity

    Directory of Open Access Journals (Sweden)

    Weipeng Hu

    2014-01-01

    Full Text Available Fluid viscosity is a significant factor resulting in the energy loss in most fluid dynamical systems. To analyze the energy loss in the pulse detonation engine (PDE due to the viscosity of the fuel, the energy loss in the Burgers model excited by periodic impulses is investigated based on the generalized multisymplectic method in this paper. Firstly, the single detonation energy is simplified as an impulse; thus the complex detonation process is simplified. And then, the symmetry of the Burgers model excited by periodic impulses is studied in the generalized multisymplectic framework and the energy loss expression is obtained. Finally, the energy loss in the Burgers model is investigated numerically. The results in this paper can be used to explain the difference between the theoretical performance and the experimental performance of the PDE partly. In addition, the analytical approach of this paper can be extended to the analysis of the energy loss in other fluid dynamic systems due to the fluid viscosity.

  3. DNA replication origins in archaea

    OpenAIRE

    Zhenfang eWu; Jingfang eLiu; Haibo eYang; Hua eXiang

    2014-01-01

    DNA replication initiation, which starts at specific chromosomal site (known as replication origins), is the key regulatory stage of chromosome replication. Archaea, the third domain of life, use a single or multiple origin(s) to initiate replication of their circular chromosomes. The basic structure of replication origins is conserved among archaea, typically including an AT-rich unwinding region flanked by several conserved repeats (origin recognition box, ORB) that are located adjacent to ...

  4. Application of a Schlieren diagnostic to the behavior of exploding bridge wire and laser detonators

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, Michael J [Los Alamos National Laboratory; Clarke, Steven A [Los Alamos National Laboratory; Munger, Alan C [Los Alamos National Laboratory; Thomas, Keith A [Los Alamos National Laboratory

    2009-01-01

    Even though the exploding bridge wire (EBW) detonator has been in use for over 60 years, there are still discussions about the mechanism for achieving detonation. Los Alamos has been developing a high-power laser detonator to function in a manner similar to an EBW. Schlieren imaging techniques are applied to laser-driven detonator output in polydimethylsiloxane (POMS) samples to investigate the time-dependent geometry of the shock wave and to obtain instantaneous measurements of shock-front velocity. Velocity Hugoniot data are used to convert measured shock velocities to corresponding particle velocities, allowing instantaneous shock pressures to be obtained via Rankine-Hugoniot relations across the shock.

  5. Role of inlet reactant mixedness on the thermodynamic performance of a rotating detonation engine

    Science.gov (United States)

    Nordeen, C. A.; Schwer, D.; Schauer, F.; Hoke, J.; Barber, T.; Cetegen, B. M.

    2016-07-01

    Rotating detonation engines have the potential to achieve the high propulsive efficiencies of detonation cycles in a simple and effective annular geometry. A two-dimensional Euler simulation is modified to include mixing factors to simulate the imperfect mixing of injected reactant streams. Contrary to expectations, mixing is shown to have a minimal impact on performance. Oblique detonation waves are shown to increase local stream thermal efficiency, which compensates for other losses in the flow stream. The degree of reactant mixing is, however, a factor in controlling the stability and existence of rotating detonations.

  6. Instability Criterion of One-Dimensional Detonation Wave with Three-Step Chain Branching Reaction Model

    Institute of Scientific and Technical Information of China (English)

    TENG Hong-Hui; JIANG Zong-Lin

    2011-01-01

    @@ One-dimensional detonation waves are simulated with the three-step chain branching reaction model, and the instability criterion is studied.The ratio of the induction zone length and the reaction zone length may be used to decide the instability, and the detonation becomes unstable with the high ratio.However, the ratio is not invariable with different heat release values.The critical ratio, corresponding to the transition from the stable detonation to the unstable detonation, has a negative correlation with the heat release.An empirical relation of the Chapman-Jouguet Mach number and the length ratio is proposed as the instability criterion.

  7. Effect of Void Size on the Detonation Pressure of Emulsion Explosives

    Science.gov (United States)

    Hirosaki, Yoshikazu; Murata, Kenji; Kato, Yukio; Itoh, Shigeru

    2002-07-01

    To study the effect of void size, detonation pressure as well as detonation velocity was measured using PVDF pressure gauge for the emulsion explosives sensitized with plastic balloons of five different size ranging from 0.05mm to 2.42mm. The experimental results were compared with the detonation pressure and velocity calculated using KHT code. The experimental results showed that the detonation pressure and velocity were strongly affected by void size, and that the fraction of ammonium nitrate reacted in the reaction zone was strongly dependent on void size.

  8. Ignition and growth reactive flow modeling of recent HMX/TATB detonation experiments

    Science.gov (United States)

    Tarver, Craig M.

    2017-01-01

    Two experimental studies in which faster HMX detonation waves produced oblique detonation waves in adjoining slower detonating TATB charges were modeled using the Ignition and Growth (I&G) reactive flow detonation model parameters for PBX 9501 (95% HMX / 2.5% Estane / 2.5% BDNPA/F) and PBX 9502 (95% TATB / 5% Kel-F binder). Matignon et al. used X1 explosive (96% HMX / 4% binder) to drive an oblique detonation wave into an attached charge of T2 explosive (97% TATB / 3% binder). The flow angles were measured in the T2 shock initiation region and in steady T2 detonation. Anderson et al. used detonating PBX 9501 slabs of various thicknesses ranging from 0.56 mm to 2.5 mm to create oblique detonation waves in 8 mm thick slabs of PBX 9502. Several diagnostics were employed to: photograph the waves; measure detonation velocities and flow angles; and determine the output of the PBX 9501 slabs, the PBX 9502 slabs, and the "initiation regions" using LiF windows and PDV probes.

  9. Dynamics of the formation of the condensed phase particles at detonation of high explosives

    CERN Document Server

    Evdokov, O V; Kulipanov, G N; Luckjanchikov, L A; Lyakhov, N Z; Mishnev, S I; Sharafutdinov, M R; Sheromov, M A; Ten, K A; Titov, V M; Tolochko, B P; Zubkov, P I

    2001-01-01

    The article presents the results of the experimental study SAXS on condensed carbon particles that appear at the detonation of a high explosive. It was shown that the SAXS signal rises for 1.5-4 mu s after the detonation front passing. The SAXS signal in trotyl and its alloys with hexogen starts just after the compression of the material in the detonation wave. In octogen, hexogen and PETN, the SAXS signal appears in 0.5 mu s and is much smaller than the signal at the detonation of trotyl and its alloys with hexogen.

  10. Replication studies in longevity

    DEFF Research Database (Denmark)

    Varcasia, O; Garasto, S; Rizza, T

    2001-01-01

    In Danes we replicated the 3'APOB-VNTR gene/longevity association study previously carried out in Italians, by which the Small alleles (less than 35 repeats) had been identified as frailty alleles for longevity. In Danes, neither genotype nor allele frequencies differed between centenarians and 20...

  11. Replication-Fork Dynamics

    NARCIS (Netherlands)

    Duderstadt, Karl E.; Reyes-Lamothe, Rodrigo; van Oijen, Antoine M.; Sherratt, David J.

    2014-01-01

    The proliferation of all organisms depends on the coordination of enzymatic events within large multiprotein replisomes that duplicate chromosomes. Whereas the structure and function of many core replisome components have been clarified, the timing and order of molecular events during replication re

  12. Coronavirus Attachment and Replication

    Science.gov (United States)

    1988-03-28

    synthesis during RNA replication of vesicular stomatitis virus. J. Virol. 49:303-309. Pedersen, N.C. 1976a. Feline infectious peritonitis: Something old...receptors on intestinal brush border membranes from normal host species were developed for canine (CCV), feline (FIPV), porcine (TGEV), human (HCV...gastroenteritis receptor on pig BBMs ...... ................. ... 114 Feline infectious peritonitis virus receptor on cat BBMs ... .............. 117 Human

  13. Shock-to-detonation transition in solid heterogeneous explosives; La transition choc-detonation dans les explosifs solides heterogenes

    Energy Technology Data Exchange (ETDEWEB)

    Belmas, R.

    2003-07-01

    This paper is an overview of the studies performed during the last decades on the shock-to-detonation transition process in heterogeneous explosives. We present the experimental and theoretical approaches mentioned in the literature and/or developed at CEA/DAM. The aim is to identify which main mechanisms govern this transition process and to evaluate the relevance of the available modeling tools. (author)

  14. Effect of pellet coatings on PETN porosity and slapper detonator efficacy

    Science.gov (United States)

    Brown, Kathryn E.; Monroe, Deirdre C.; Brown, Geoffrey W.

    2017-01-01

    Pentaerythritol tetranitrate (PETN) is well known to have a high vapor pressure and to sublime and decompose when heated. Preliminary experiments conducted in 2014 suggest that at 80°C for 6 days, a 1.65 g/cm3 PETN pellet will develop crystals and a layer of increased porosity on the pellet surface, due to sublimation and re-deposition of PETN crystals in an equilibrium environment. This phenomenon may decrease the pressed PETN pellet's sensitivity to shock initiation in a slapper detonator. In this report, we detail preliminary attempts to mitigate sublimation and recrystallization by coating the flyer impact surface of pressed PETN pellets with 200 nm of gold. No crystallization occurred on the surface of the coated, heated surface, and firing thresholds for the coated pellets did not appreciably change with heating. Recent attempts to replicate the effects of heating bare PETN pellets contradict the 2014 experiments, and potential explanations include different PETN batches and different heating schemes. Current and future research directions, including coating with Parylene C, are also presented.

  15. Analysis of Morphology of Oblique Detonation Wave in H2-Air Mixture%氢-空气斜爆震波的极曲线分析

    Institute of Scientific and Technical Information of China (English)

    伍智超; 郭印诚

    2012-01-01

    本文建立了一种以温度为单变量进行迭代,求解真实气体模型下的斜爆震波波后参数非线性方程组的方法。并通过以加热量和气流偏转角为变量,计算出对应斜爆震波角度和斜爆震波的驻定范围。对于给定的来流条件,基于真实气体模型的斜爆震波的驻定范围比量热完全气体的宽,所以在斜爆震波的计算中必须考虑热物性的影响。随着氢气和空气化学当量比的增加,斜爆震波驻定范围逐步变小。而来流马赫数越大,斜爆震波的驻定范围越大,其CJ爆震波对应的平面偏转角越小。来流初温的升高则使斜爆震波的驻定范围变宽。斜爆震波的驻定需要来流条件与斜面角度等因素的相互匹配。%A numerical method of single variable iteration by temperature for solving nonlinear equations of real gas model was developed. Theoretical analysis gives effect of different heat flux and deflection angles of gas on the angle of oblique detonation wave(ODW). For a given H2-air mixture flow, the standing range of the oblique detonation wave predicted by the real gas model is larger than that by the calorically perfect gas model, this indicates that the thermal property should be considered when calculating an oblique detonation wave. With the equivalence ratio of hydrogen to air increasing, the standing range of the oblique detonation wave is changing small. With the Mach number of oncoming flow increasing, the standing range of the oblique detonation wave increases, and the minimum turning angles of Chapman-Jouguet states decrease. The increased temperature of oncoming flow is beneficial to promote the standing range of the oblique detonation wave. The standing ability of oblique detonation wave relates to the oncoming flow condition and the angle of wedge.

  16. Numerical Analysis of a Pulse Detonation Cross Flow Heat Load Experiment

    Science.gov (United States)

    Paxson, Daniel E.; Naples, Andrew .; Hoke, John L.; Schauer, Fred

    2011-01-01

    A comparison between experimentally measured and numerically simulated, time-averaged, point heat transfer rates in a pulse detonation (PDE) engine is presented. The comparison includes measurements and calculations for heat transfer to a cylinder in crossflow and to the tube wall itself using a novel spool design. Measurements are obtained at several locations and under several operating conditions. The measured and computed results are shown to be in substantial agreement, thereby validating the modeling approach. The model, which is based in computational fluid dynamics (CFD) is then used to interpret the results. A preheating of the incoming fuel charge is predicted, which results in increased volumetric flow and subsequent overfilling. The effect is validated with additional measurements.

  17. Wear resistance of a Cr3C2-NiCr detonation spray coating

    Science.gov (United States)

    Wang, Jun; Wang, Jun; Sun, Baode; Guo, Qixin; Nishio, Mitsuhiro; Ogawa, Hiroshi

    2002-06-01

    Coatings can be applied to surfaces to improve the surface characteristics over those of the bulk properties and are widely used in tribological applications either to reduce wear and/or to modify friction during contact. One of the foremost coating methods for combating wear is thermal spraying. To prolong the life of steel slab continuous casting rolls, Cr3C2-NiCr detonation spray coating was processed on the roll surface in a steelmaking plant in China. This article studies the mechanical properties and wear resistance of this coating. The abrasive and dry frictional wear testing were performed using a pin-on-disk tester. Experimental results show that the wear resistance of the coated samples, i.e., coating reduces the risk of seizure compared to uncoated samples, is much better than those of the uncoated steel at room and elevated temperatures with any load and sliding velocity. The coating wear mechanisms under different test conditions are discussed.

  18. Interneuron diversity series: containing the detonation--feedforward inhibition in the CA3 hippocampus.

    Science.gov (United States)

    Lawrence, J Josh; McBain, Chris J

    2003-11-01

    Feedforward inhibitory circuits are involved both in the suppression of excitability and timing of action potential generation in principal cells. In the CA3 hippocampus, a single mossy fiber from a dentate gyrus granule cell forms giant boutons with multiple release sites, which are capable of detonating CA3 principal cells. By contrast, mossy fiber terminals form a larger number of Lilliputian-sized synapses with few release sites onto local circuit interneurons, with distinct presynaptic and postsynaptic properties. This dichotomy between the two synapse types endows the circuit with exquisite control over pyramidal cell discharge. Under pathological conditions where feedforward inhibition is compromised, focal excitation is no longer contained, rendering the circuit susceptible to hyperexcitability.

  19. CXCR4启动子的条件复制型腺病毒对肺癌细胞的靶向杀伤作用%Conditionally replicating adenovirus activated by CXCR4 promoter in lung cancer

    Institute of Scientific and Technical Information of China (English)

    李龙光; 李书华; 王红艳; 龙捷; 谢晓斌; 张雅洁

    2015-01-01

    [ ABSTRACT] AIM:To construct a conditionally replicating adenovirus vector activated by CXCR4 promoter and to evaluate its ability of lysing the lung cancer cells specifically.METHODS:Human CXCR4-E1A gene amplified by PCR was cloned into the shuttle plasmid pDC316-GFP to construct the recombinant shuttle plasmid pDC316-CXCR4-GFP.The recombinat shuttle plasmid and adenovirus genomic plasmid pBHG-lox-E1, 3Cre were transfected into 293 cells to construct the recombinant adenovirus CRAd-CXCR4-GFP.PCR was used to detect the target gene fragments, and the viral titer was determined.A549 cells with the highest mRNA expression of CXCR4 were screened out from 5 kinds of lung cancer cell lines by real-time PCR.CXCR4 promoter activity and adenovirus replication numbers were detected in A549 cells after transfection of CRAd-CXCR4-GFP and Ad-NULL.CRAd-CXCR4-GFP and Ad-NULL were transfected into A549 cells and 16HBE cells, the apoptotic rates were detected by flow cytometry and the viability was analyzed by CCK-8 assay.RE-SULTS:The recombinant plasmid pDC316-CXCR4-GFP was constructed successfully.Green fluorescence was observed in 293 cells under fluorescent microscope after co-transfection of pDC316-CXCR4-GFP and pBHG-lox-E1, 3Cre at 11 d. Green fluorescence was observed in 293 cells after infection of amplified 3rd generational adenovirus.PCR showed that the purpose gene was successfully integrated in recombinant adenovirus genome.The virus in the supernatant reached a titer of 1 ×1013 PFU/L.The mRNA expression of E1A and E4 in the A549 cells after transfection of CRAd-CXCR4-GFP was markedly increased compared with Ad-NULL group.Compared with Ad-NULL group and empty control group, the apoptotic rate and the viability of A549 cells in CRAd-CXCR4-GFP group had no significant difference in the first 4 d, the apoptotic rate increased significantly at 5 d, and the cell viability declined significantly at 5 d, but the apoptotic rate and the viability of 16HBE cells in each group

  20. The Alleged Crisis and the Illusion of Exact Replication.

    Science.gov (United States)

    Stroebe, Wolfgang; Strack, Fritz

    2014-01-01

    There has been increasing criticism of the way psychologists conduct and analyze studies. These critiques as well as failures to replicate several high-profile studies have been used as justification to proclaim a "replication crisis" in psychology. Psychologists are encouraged to conduct more "exact" replications of published studies to assess the reproducibility of psychological research. This article argues that the alleged "crisis of replicability" is primarily due to an epistemological misunderstanding that emphasizes the phenomenon instead of its underlying mechanisms. As a consequence, a replicated phenomenon may not serve as a rigorous test of a theoretical hypothesis because identical operationalizations of variables in studies conducted at different times and with different subject populations might test different theoretical constructs. Therefore, we propose that for meaningful replications, attempts at reinstating the original circumstances are not sufficient. Instead, replicators must ascertain that conditions are realized that reflect the theoretical variable(s) manipulated (and/or measured) in the original study.

  1. Synchronization of DNA array replication kinetics

    Science.gov (United States)

    Manturov, Alexey O.; Grigoryev, Anton V.

    2016-04-01

    In the present work we discuss the features of the DNA replication kinetics at the case of multiplicity of simultaneously elongated DNA fragments. The interaction between replicated DNA fragments is carried out by free protons that appears at the every nucleotide attachment at the free end of elongated DNA fragment. So there is feedback between free protons concentration and DNA-polymerase activity that appears as elongation rate dependence. We develop the numerical model based on a cellular automaton, which can simulate the elongation stage (growth of DNA strands) for DNA elongation process with conditions pointed above and we study the possibility of the DNA polymerases movement synchronization. The results obtained numerically can be useful for DNA polymerase movement detection and visualization of the elongation process in the case of massive DNA replication, eg, under PCR condition or for DNA "sequencing by synthesis" sequencing devices evaluation.

  2. GFLV replication in electroporated grapevine protoplasts.

    Science.gov (United States)

    Valat; Toutain; Courtois; Gaire; Decout; Pinck; Mauro; Burrus

    2000-06-29

    Grapevine fanleaf virus (GFLV), responsible for the economically important court-noué disease, is exclusively transmitted to its natural host in the vineyards through Xiphinema nematodes. We have developed direct inoculation of GFLV into grapevine through protoplast electroporation. Protoplasts were isolated from mesophyll of in vitro-grown plants and from embryogenic cell suspensions. Permeation conditions were determined by monitoring calcein uptake. Low salt poration medium was selected. Electrical conditions leading to strong transient gene expression were also tested for GFLV inoculation (isolate F13). GFLV replication was detected with either virus particles (2 µg) or viral RNA (10 ng) in both protoplast populations, as shown by anti-P38 Western blotting. Direct inoculation and replication were also observed with Arabis mosaic virus (ArMV), a closely related nepovirus, as well as with another GFLV isolate. These results will be valuable in grapevine biotechnology, for GFLV replication studies, transgenic plant screening for GFLV resistance, and biorisk evaluation.

  3. Neutrinos from type Ia supernovae: The deflagration-to-detonation transition scenario

    Science.gov (United States)

    Wright, Warren P.; Nagaraj, Gautam; Kneller, James P.; Scholberg, Kate; Seitenzahl, Ivo R.

    2016-07-01

    It has long been recognized that the neutrinos detected from the next core-collapse supernova in the Galaxy have the potential to reveal important information about the dynamics of the explosion and the nucleosynthesis conditions as well as allowing us to probe the properties of the neutrino itself. The neutrinos emitted from thermonuclear—type Ia—supernovae also possess the same potential, although these supernovae are dimmer neutrino sources. For the first time, we calculate the time, energy, line of sight, and neutrino-flavor-dependent features of the neutrino signal expected from a three-dimensional delayed-detonation explosion simulation, where a deflagration-to-detonation transition triggers the complete disruption of a near-Chandrasekhar mass carbon-oxygen white dwarf. We also calculate the neutrino flavor evolution along eight lines of sight through the simulation as a function of time and energy using an exact three-flavor transformation code. We identify a characteristic spectral peak at ˜10 MeV as a signature of electron captures on copper. This peak is a potentially distinguishing feature of explosion models since it reflects the nucleosynthesis conditions early in the explosion. We simulate the event rates in the Super-K, Hyper-K, JUNO, and DUNE neutrino detectors with the SNOwGLoBES event rate calculation software and also compute the IceCube signal. Hyper-K will be able to detect neutrinos from our model out to a distance of ˜10 kpc . At 1 kpc, JUNO, Super-K, and DUNE would register a few events while IceCube and Hyper-K would register several tens of events.

  4. He-detonation in sub-Chandrasekhar CO white dwarfs a new insight into energetics and p-process nucleosynthesis

    CERN Document Server

    Goriely, S; Hernanz, M; Rayet, M; Arnould, M; Goriely, Stephane; Jose, Jordi; Hernanz, Margarita; Rayet, Marc; Arnould, Marcel

    2002-01-01

    He-accreting white dwarfs with sub-Chandrasekhar mass are revisited. The impact of the use of an extended reaction network on the predicted energy production and characteristics of the detonating layers is studied. It is shown that the considered scenario can be the site of an $\\alpha$p-process combined with a p-process and with a variant of the rp-process we refer to as the pn-process. We define the conditions under which the derived distribution of the abundances of the p-nuclides in the ejecta, including the puzzling light Mo and Ru isotopes, mimics the solar-system one.

  5. He-detonation in sub-Chandrasekhar CO white dwarfs: A new insight into energetics and p-process nucleosynthesis

    Science.gov (United States)

    Goriely, S.; José, J.; Hernanz, M.; Rayet, M.; Arnould, M.

    2002-03-01

    He-accreting white dwarfs with sub-Chandrasekhar mass are revisited. The impact of the use of an extended reaction network on the predicted energy production and characteristics of the detonating layers is studied. It is shown that the considered scenario can be the site of an alpha p-process combined with a p-process and with a variant of the rp-process we refer to as the pn-process. We define the conditions under which the derived distribution of the abundances of the p-nuclides in the ejecta, including the puzzling light Mo and Ru isotopes, mimics the solar-system one.

  6. Operational Characteristics of a Rotating Detonation Engine Using Hydrogen and Air

    Science.gov (United States)

    2011-06-01

    speeds but eventually transition to supersonic detonation waves in a process known as deflagration to detonation transition (DDT). The residual hot...To obtain the Hugoniot curve, Eqs. 13, 14, and 15 are combined with the following ideal gas relations (Eqs. 16 through 18) and the caloric

  7. 30 CFR 75.1312 - Explosives and detonators in underground magazines.

    Science.gov (United States)

    2010-07-01

    ... magazines. 75.1312 Section 75.1312 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF... Blasting § 75.1312 Explosives and detonators in underground magazines. (a) The quantity of explosives kept..., explosives and detonators taken underground shall be kept in— (1) Separate, closed magazines at least 5...

  8. 30 CFR 75.1313 - Explosives and detonators outside of magazines.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Explosives and detonators outside of magazines... § 75.1313 Explosives and detonators outside of magazines. (a) The quantity of explosives outside a magazine for use in a working section or other area where blasting is to be performed shall— (1) Not...

  9. 33 CFR 154.822 - Detonation arresters, flame arresters, and flame screens.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Detonation arresters, flame arresters, and flame screens. 154.822 Section 154.822 Navigation and Navigable Waters COAST GUARD... BULK Vapor Control Systems § 154.822 Detonation arresters, flame arresters, and flame screens. (a)...

  10. Impact of Dissociation and Sensible Heat Release on Pulse Detonation and Gas Turbine Engine Performance

    Science.gov (United States)

    Povinelli, Louis A.

    2001-01-01

    A thermodynamic cycle analysis of the effect of sensible heat release on the relative performance of pulse detonation and gas turbine engines is presented. Dissociation losses in the PDE (Pulse Detonation Engine) are found to cause a substantial decrease in engine performance parameters.

  11. Detonation chemistry: an investigation of fluorine as an oxidizing moiety in explosives

    Energy Technology Data Exchange (ETDEWEB)

    McGuire, R.R.; Ornellas, D.L.; Helm, F.H.; Coon, C.L.; Finger, M.

    1982-07-07

    We have investigated the use of fluorine in the form of the difluoramino (NF/sub 2/) group as an oxidizing moiety. Bis- and tris-difluoramino perfluorobutane, previously unknown, were especially synthesized for this study. We performed detonation calorimetry to determine the exact detonation product composition and the heat of detonation of a series of NF/sub 2/ compounds and mixtures. We then performed cylinder tests to determine their detonation performance. Similar tests on NO/sub 2/ compounds were used for comparison. For reasons of toxicity and safety, we designed and built remote mixing and loading apparati for certain of the materials. Materials were chosen to highlight certain of the detonation products. Hydrogen fluoride was found to be a favorable detonation product compared with H/sub 2/O; CO/sub 2/ outperforms CF/sub 4/ at all cylinder expansion ratios; and Al/sub 2/O/sub 3/ was a favorable detonation product compared to AlF/sub 3/. The most important result is better understanding of the mechanism of reaction of small-particle aluminum in a detonation.

  12. The detonation parameters of high energy density explosive predicted with a new revised VLW EOS

    Energy Technology Data Exchange (ETDEWEB)

    Xinping, L.; Xiaohua, J. [Southwest Institut of Chemical Mat. Chengdu Sichuan (China); Xiong, W. [Xian Modern Chemistry Research Institute (China)

    1996-12-31

    Some new target explosive compounds whose detonation performance significantly exceeds that of HMX have been predicted with the new revised VLM equation of state, which includes up to the sixth viral term. The two different hypotheses have been used in the calculation; solid carbon exists in detonation products as graphite or as diamond. (authors) 10 refs.

  13. Development and Testing of a Rotating Detonation Engine Run on Hydrogen and Air

    Science.gov (United States)

    2012-03-22

    Jay Rutledge (Member) Date v AFIT/GAE/ENY/12-M36 Abstract Rotating detonation engines (RDEs) have the potential for greater...like to thank John Hoke, Andrew Naples, Jim Suchoki, Brian Sell, and Chris Stevens for sharing their knowledge of rotating detonation engines and

  14. Chromatin replication and epigenome maintenance

    DEFF Research Database (Denmark)

    Alabert, Constance; Groth, Anja

    2012-01-01

    initiates, whereas the replication process itself disrupts chromatin and challenges established patterns of genome regulation. Specialized replication-coupled mechanisms assemble new DNA into chromatin, but epigenome maintenance is a continuous process taking place throughout the cell cycle. If DNA...

  15. Chromatin replication and epigenome maintenance

    DEFF Research Database (Denmark)

    Alabert, Constance; Groth, Anja

    2012-01-01

    initiates, whereas the replication process itself disrupts chromatin and challenges established patterns of genome regulation. Specialized replication-coupled mechanisms assemble new DNA into chromatin, but epigenome maintenance is a continuous process taking place throughout the cell cycle. If DNA...

  16. An Explosives Products Thermodynamic Equation of State Appropriate for Material Acceleration and Overdriven Detonation: Theoretical Background and Formulation

    Science.gov (United States)

    1991-07-01

    9 i 1 Normally, the equation of state parameters are chosen so that E. has the value E. = p0AH, where AH is the heat of detonation . This is consistent...Initial Specific Volume a Gruneisen Parameter 7 Adiabatic Gamnma C Sound Speed D) Detonation Velocity U mMass Velocity A 1l Heat of Detonation B ;., R xi

  17. Application of the CE/SE Method to a Two-Phase Detonation Model in Porous Media

    Institute of Scientific and Technical Information of China (English)

    DONG He-Fei; HONG Tao; ZHANG De-Liang

    2011-01-01

    We extend the conservation-element and solution-element method to simulate a two-phase detonation model in porous media. The accuracy of the method is validated by calculating an inert compaction problem. The main characteristics of piston-driven detonation phenomena, including the compaction wave, the onset of combustion,and the transition to detonation, could be predicted successfully.

  18. A numerical study of two- and three-dimensional detonation dynamics of pulse detonation engine by the CE/SE method

    Institute of Scientific and Technical Information of China (English)

    Chunsheng Weng; Jay P. Gore

    2005-01-01

    In this paper, the CE/SE method is developed to simulate the two- and three-dimensional flow-field of Pulse Detonation Engine (PDE). The conservation equations with stiff source terms for chemical reaction are solved in two steps. The detailed analysis of computational results of a PDE with a single detonation tube and a PDE with five detonation tubes are given in this paper. Complex wave systems are observed inside and outside a PDE. For a PDE with 5 detonation tubes, there is a big bow shock produced from a number of little shocks near the open ends of tubes. A lot of vortexes interact with shocks and a large expansion wave propagates forward and backward with respect to the PDE in a semi-oval shape.

  19. Plasma-assisted ignition and deflagration-to-detonation transition.

    Science.gov (United States)

    Starikovskiy, Andrey; Aleksandrov, Nickolay; Rakitin, Aleksandr

    2012-02-13

    Non-equilibrium plasma demonstrates great potential to control ultra-lean, ultra-fast, low-temperature flames and to become an extremely promising technology for a wide range of applications, including aviation gas turbine engines, piston engines, RAMjets, SCRAMjets and detonation initiation for pulsed detonation engines. The analysis of discharge processes shows that the discharge energy can be deposited into the desired internal degrees of freedom of molecules when varying the reduced electric field, E/n, at which the discharge is maintained. The amount of deposited energy is controlled by other discharge and gas parameters, including electric pulse duration, discharge current, gas number density, gas temperature, etc. As a rule, the dominant mechanism of the effect of non-equilibrium plasma on ignition and combustion is associated with the generation of active particles in the discharge plasma. For plasma-assisted ignition and combustion in mixtures containing air, the most promising active species are O atoms and, to a smaller extent, some other neutral atoms and radicals. These active particles are efficiently produced in high-voltage, nanosecond, pulse discharges owing to electron-impact dissociation of molecules and electron-impact excitation of N(2) electronic states, followed by collisional quenching of these states to dissociate the molecules. Mechanisms of deflagration-to-detonation transition (DDT) initiation by non-equilibrium plasma were analysed. For longitudinal discharges with a high power density in a plasma channel, two fast DDT mechanisms have been observed. When initiated by a spark or a transient discharge, the mixture ignited simultaneously over the volume of the discharge channel, producing a shock wave with a Mach number greater than 2 and a flame. A gradient mechanism of DDT similar to that proposed by Zeldovich has been observed experimentally under streamer initiation.

  20. Initiation of adenovirus DNA replication.

    OpenAIRE

    Reiter, T; Fütterer, J; Weingärtner, B; Winnacker, E L

    1980-01-01

    In an attempt to study the mechanism of initiation of adenovirus DNA replication, an assay was developed to investigate the pattern of DNA synthesis in early replicative intermediates of adenovirus DNA. By using wild-type virus-infected cells, it was possible to place the origin of adenovirus type 2 DNA replication within the terminal 350 to 500 base pairs from either of the two molecular termini. In addition, a variety of parameters characteristic of adenovirus DNA replication were compared ...

  1. Chromatin replication and epigenome maintenance

    DEFF Research Database (Denmark)

    Alabert, Constance; Groth, Anja

    2012-01-01

    Stability and function of eukaryotic genomes are closely linked to chromatin structure and organization. During cell division the entire genome must be accurately replicated and the chromatin landscape reproduced on new DNA. Chromatin and nuclear structure influence where and when DNA replication...... initiates, whereas the replication process itself disrupts chromatin and challenges established patterns of genome regulation. Specialized replication-coupled mechanisms assemble new DNA into chromatin, but epigenome maintenance is a continuous process taking place throughout the cell cycle. If DNA...

  2. Surface Micro Topography Replication in Injection Moulding

    DEFF Research Database (Denmark)

    Arlø, Uffe Rolf; Hansen, Hans Nørgaard; Kjær, Erik Michael

    2005-01-01

    The surface micro topography of injection moulded plastic parts can be important for aesthetical and technical reasons. The quality of replication of mould surface topography onto the plastic surface depends among other factors on the process conditions. A study of this relationship has been...

  3. Deflagration-to-detonation transition in gases in tubes with cavities

    Science.gov (United States)

    Smirnov, N. N.; Nikitin, V. F.; Phylippov, Yu. G.

    2010-12-01

    The existence of a supersonic second combustion mode — detonation — discovered by Mallard and Le Chatelier and by Berthélot and Vieille in 1881 posed the question of mechanisms for transition from one mode to the other. In the period 1959-1969, experiments by Salamandra, Soloukhin, Oppenheim, and their coworkers provided insights into this complex phenomenon. Since then, among all the phenomena related to combustion processes, deflagration-to-detonation transition is, undoubtedly, the most intriguing one. Deflagration-to-detonation transition (DDT) in gases is connected with gas and vapor explosion safety issues. Knowing mechanisms of detonation onset control is of major importance for creating effective mitigation measures addressing two major goals: to prevent DDT in the case of mixture ignition, or to arrest the detonation wave in the case where it has been initiated. A new impetus to the increase in interest in deflagration-to-detonation transition processes was given by the recent development of pulse detonation devices. The probable application of these principles to creation of a new generation of engines put the problem of effectiveness of pulse detonating devices at the top of current research needs. The effectiveness of the pulse detonation cycle turned out to be the key factor characterizing the Pulse Detonation Engine (PDE), whose operation modes were shown to be closely related to periodical onset and degeneration of a detonation wave. Those unsteady-state regimes should be self-sustained to guarantee a reliable operation of devices using the detonation mode of burning fuels as a constitutive part of their working cycle. Thus deflagration-to-detonation transition processes are of major importance for the issue. Minimizing the predetonation length and ensuring stability of the onset of detonation enable one to increase the effectiveness of a PDE. The DDT turned out to be the key factor characterizing the PDE operating cycle. Thus, the problem of

  4. Simple correlation for predicting detonation velocity of ideal and non-ideal explosives.

    Science.gov (United States)

    Keshavarz, Mohammad Hossein

    2009-07-30

    This paper describes a simple method for prediction of detonation velocity of ideal and non-ideal explosives. A non-ideal aluminized and nitrated explosive can have Chapman-Jouguet detonation velocity significantly different from that expected from existing thermodynamic computer codes for equilibrium and steady-state calculations. Detonation velocity of explosives with general formula C(a)H(b)N(c)O(d)Al(e) can be predicted only from values of a, b, c, d, e and a specific structural parameter without using any assumed detonation products, heat of formation and experimental data. Predicted detonation velocities by this procedure for ideal and non-ideal explosives show good agreement with respect to experimental values as compared to computed results of BKWR and BKWS equations of state.

  5. Theoretical studies on the structures and detonation properties of nitramine explosives containing benzene ring.

    Science.gov (United States)

    Zhao, GuoZheng; Lu, Ming

    2012-06-01

    The nitramine compounds containing benzene ring were optimized to obtain their molecular geometries and electronic structures at DFT-B3LYP/6-31+G(d) level. The theoretical molecular density (ρ), heat of formation (HOF), energy gap (ΔE(LUMO-HOMO)), charge on the nitro group (-Q(NO2)), detonation velocity (D) and detonation pressure (P), estimated using Kamlet-Jacobs equations, showed that the detonation properties of these compounds were excellent. It is found that there are good linear relationships between density, heat of formation, detonation velocity, detonation pressure and the number of nitro group. The simulation results reveal that molecule G performs similarly to famous explosive HMX, and molecule H outperforms HMX. According to the quantitative standard of energetics as an HEDC (high energy density compound), molecule H essentially satisfies this requirement. These results provide basic information for molecular design of novel high energetic density compounds.

  6. Numerical investigation on detonation cell evolution in a channel with area-changing cross section

    Institute of Scientific and Technical Information of China (English)

    DENG; Bo

    2007-01-01

    The two-dimensional cellular detonation propagating in a channel with area- changing cross section was numerically simulated with the dispersion-controlled dissipative scheme and a detailed chemical reaction model. Effects of the flow expansion and compression on the cellular detonation cell were investigated to illustrate the mechanism of the transverse wave development and the cellular detonation cell evolution. By examining gas composition variations behind the leading shock, the chemical reaction rate, the reaction zone length, and thermodynamic parameters, two kinds of the abnormal detonation waves were identified. To explore their development mechanism, chemical reactions, reflected shocks and rarefaction waves were discussed, which interact with each other and affect the cellular detonation in different ways.  ……

  7. Research on design and firing performance of Si-based detonator

    Institute of Scientific and Technical Information of China (English)

    Rui-zhen XIE; Xiao-ming REN; Lan LIU; Yan XUE; Dong-xiao FU; Rui ZHANG

    2014-01-01

    For the chip integration of MEMS (micro-electromechanical system) safety and arming device, a miniature detonator needs to be developed to reduce the weight and volume of explosive train. A Si-based micro-detonator is designed and fabricated, which meets the requirement of MEMS safety and arming device. The firing sensitivity of micro-detonator is tested according to GJB/z377A-94 sensitivity test methods:Langlie. The function time of micro-detonator is measured using wire probe and photoelectric transducer. The result shows the average firing voltage is 6.4 V when the discharge capacitance of firing electro-circuit is 33 mF. And the average function time is 5.48 ms. The firing energy actually utilized by Si-based micro-detonator is explored.

  8. Numerical investigation on detonation cell evolution in a channel with area-changing cross section

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The two-dimensional cellular detonation propagating in a channel with area- changing cross section was numerically simulated with the dispersion-controlled dissipative scheme and a detailed chemical reaction model. Effects of the flow expansion and compression on the cellular detonation cell were investigated to illustrate the mechanism of the transverse wave development and the cellular detonation cell evolution. By examining gas composition variations behind the leading shock, the chemical reaction rate, the reaction zone length, and thermodynamic parameters, two kinds of the abnormal detonation waves were identified. To explore their development mechanism, chemical reactions, reflected shocks and rarefaction waves were discussed, which interact with each other and affect the cellular detonation in different ways.

  9. INCREASING MEASUREMENT ACCURACY IN ELECTRO-OPTICAL METHOD FOR MEASURING VELOCITY OF DETONATION

    Directory of Open Access Journals (Sweden)

    Mario Dobrilović

    2014-12-01

    Full Text Available In addition to other detonation parameters detonation velocity is a value that provides indirect information on the strength i.e. brisance of an explosive and explosive performance. In addition to that, detonation velocity is a value which can be measured in a relatively simpler and more precise manner, by developed and accessible methods when compared to other detonation parameters Due to its simple use, compact instruments and satisfactory accuracy, electro-optical method of detonation velocity measurement is widely used. The paper describes the electro-optical measurement method and points out the factors that affect its accuracy. The accuracy of measurement is increased and measurement uncertainty is reduced by the measurement result analysis with the application of different measurement setups.

  10. Introduction to Physics and Chemistry of Combustion Explosion, Flame, Detonation

    CERN Document Server

    Liberman, Michael A

    2008-01-01

    Most of the material covered in this book deals with the fundamentals of chemistry and physics of key processes and fundamental mechanisms for various combustion and combustion related phenomena in gaseous combustible mixture. It provides the reader with basic knowledge of burning processes and mechanisms of reaction wave propagation. The combustion of a gas mixture (flame, explosion, detonation) is necessarily accompanied by motion of the gas. The process of combustion is therefore not only a chemical phenomenon but also one of gas dynamics. The material selection focuses on the gas phase and

  11. Deflagration-to-Detonation Transition in Unconfined Media

    Science.gov (United States)

    Poludnenko, Alexei; Gardiner, Thomas; Oran, Elaine

    2011-11-01

    Deflagration-to-detonation transition (DDT) can occur in environments ranging from experimental and industrial systems on Earth to astrophysical thermonuclear supernovae explosions. In recent years, substantial progress has been made in elucidating the nature of this process in confined systems with walls, obstacles, etc. It remains unclear, however, whether a subsonic turbulent flame in an unconfined environment can undergo a DDT. We present simulations of premixed flames in stoichiometric H2-air and CH4-air mixtures interacting with high-intensity turbulence. These calculations demonstrate the DDT in unconfined systems unassisted by shocks or obstacles. We discuss the mechanism of this process and its implications.

  12. Deflagration-to-Detonation Transition Control by Nanosecond Gas Discharges

    Science.gov (United States)

    2008-04-07

    to a voltage of 37 kV. A high-voltage pulse was formed on the electrode when the feeding line had been grounded by the thyratron (5). The pulse...width – 1–3 µs, rise time – ∼100 ns. The rise time was determined by thyratron switching time. The energy input in this case was limited by the energy...Kapila, A. K., Schwendeman, D. W., Quirk, J. J., and Hawa, T., “Mech- anisms of Detonation Formation due to a Temperature Gradient,” Com- bustion Theory and Modelling , Vol. 6, No. 4, 2002, pp. 553–594. 74

  13. Effects of hypothetical improvised nuclear detonation on the electrical infrastructure

    Energy Technology Data Exchange (ETDEWEB)

    Barrett, Christopher L.; Eubank, Stephen; Evrenosoglu, C. Yaman; Marathe, Achla; Marathe, Madhav V.; Phadke, Arun; Thorp, James; Vullikanti, Anil [Virginia Tech, Blacksburg, VA (United States). Network Dynamics and Simulation Science Lab.

    2013-07-01

    We study the impacts of a hypothetical improvised nuclear detonation (IND) on the electrical infrastructure and its cascading effects on other urban inter-dependent infrastructures of a major metropolitan area in the US. We synthesize open source information, expert knowledge, commercial software and Google Earth data to derive a realistic electrical transmission and distribution network spanning the region. A dynamic analysis of the geo-located grid is carried out to determine the cause of malfunction of components, and their short-term and long-term effect on the stability of the grid. Finally a detailed estimate of the cost of damage to the major components of the infrastructure is provided.

  14. Replication Research and Special Education

    Science.gov (United States)

    Travers, Jason C.; Cook, Bryan G.; Therrien, William J.; Coyne, Michael D.

    2016-01-01

    Replicating previously reported empirical research is a necessary aspect of an evidence-based field of special education, but little formal investigation into the prevalence of replication research in the special education research literature has been conducted. Various factors may explain the lack of attention to replication of special education…

  15. Replication Research and Special Education

    Science.gov (United States)

    Travers, Jason C.; Cook, Bryan G.; Therrien, William J.; Coyne, Michael D.

    2016-01-01

    Replicating previously reported empirical research is a necessary aspect of an evidence-based field of special education, but little formal investigation into the prevalence of replication research in the special education research literature has been conducted. Various factors may explain the lack of attention to replication of special education…

  16. Replication data collection highlights value in diversity of replication attempts

    Science.gov (United States)

    DeSoto, K. Andrew; Schweinsberg, Martin

    2017-01-01

    Researchers agree that replicability and reproducibility are key aspects of science. A collection of Data Descriptors published in Scientific Data presents data obtained in the process of attempting to replicate previously published research. These new replication data describe published and unpublished projects. The different papers in this collection highlight the many ways that scientific replications can be conducted, and they reveal the benefits and challenges of crucial replication research. The organizers of this collection encourage scientists to reuse the data contained in the collection for their own work, and also believe that these replication examples can serve as educational resources for students, early-career researchers, and experienced scientists alike who are interested in learning more about the process of replication. PMID:28291224

  17. Anatomy of Mammalian Replication Domains

    Science.gov (United States)

    Takebayashi, Shin-ichiro; Ogata, Masato; Okumura, Katsuzumi

    2017-01-01

    Genetic information is faithfully copied by DNA replication through many rounds of cell division. In mammals, DNA is replicated in Mb-sized chromosomal units called “replication domains.” While genome-wide maps in multiple cell types and disease states have uncovered both dynamic and static properties of replication domains, we are still in the process of understanding the mechanisms that give rise to these properties. A better understanding of the molecular basis of replication domain regulation will bring new insights into chromosome structure and function. PMID:28350365

  18. Shock Wave Dynamics of Novel Aluminized Detonations and Empirical Model for Temperature Evolution from Post-Detonation Combustion Fireballs

    Science.gov (United States)

    2011-03-01

    astrophysical events. Cox [15] and Raymond [50] apply shock analysis to interstellar phenomena by modeling a gas as it interacts with a shock front from a...is / (6) For pure RDX at TMD of 1.81 g/cm3, its detonation wave traveling at 8.8 km/s can traverse the length of the 0.4064 m test article in...shock wave cannot propagate indefinitely. As the shock wave travels , it is attenuated from behind by a rarefaction wave [14, p. 174]. Another

  19. Content replication and placement in mobile networks

    CERN Document Server

    La, Chi-Anh; Casetti, Claudio; Chiasserini, Carla-Fabiana; Fiore, Marco

    2011-01-01

    Performance and reliability of content access in mobile networks is conditioned by the number and location of content replicas deployed at the network nodes. Location theory has been the traditional, centralized approach to study content replication: computing the number and placement of replicas in a static network can be cast as a facility location problem. The endeavor of this work is to design a practical solution to the above joint optimization problem that is suitable for mobile wireless environments. We thus seek a replication algorithm that is lightweight, distributed, and reactive to network dynamics. We devise a solution that lets nodes (i) share the burden of storing and providing content, so as to achieve load balancing, and (ii) autonomously decide whether to replicate or drop the information, so as to adapt the content availability to dynamic demands and time-varying network topologies. We evaluate our mechanism through simulation, by exploring a wide range of settings, including different node ...

  20. Type Ia Supernovae from Merging White Dwarfs I. Prompt Detonations

    CERN Document Server

    Moll, Rainer; Kasen, Daniel; Woosley, Stan

    2013-01-01

    Merging white dwarfs are a possible progenitor of Type Ia supernovae (SNe Ia). While it is not entirely clear if and when an explosion is triggered in such systems, numerical models suggest that a detonation might be initiated before the stars have coalesced to form a single compact object. Here we study such "peri-merger" detonations by means of numerical simulations, modeling the disruption and nucleosynthesis of the stars until the ejecta reach the coasting phase. Synthetic light curves and spectra are generated for comparison with observations. Three models are considered with primary masses 0.96 Msun, 1.06 Msun, and 1.20 Msun. Of these, the 0.96 Msun dwarf merging with an 0.81 Msun companion, with a Ni56 yield of 0.58 Msun, is the most promising candidate for reproducing common SNe Ia. The more massive mergers produce unusually luminous SNe Ia with peak luminosities approaching those attributed to "super-Chandrasekhar" mass SNe Ia. While the synthetic light curves and spectra of some of the models resemb...

  1. On the verification and validation of detonation models

    Science.gov (United States)

    Quirk, James

    2013-06-01

    This talk will consider the verification and validation of detonation models, such as Wescott-Stewart-Davis (Journal of Applied Physics. 2005), from the perspective of the American Institute of Aeronautics and Astronautics policy on numerical accuracy (AIAA J. Vol. 36, No. 1, 1998). A key aspect of the policy is that accepted documentation procedures must be used for journal articles with the aim of allowing the reported work to be reproduced by the interested reader. With the rise of electronic documents, since the policy was formulated, it is now possible to satisfy this mandate in its strictest sense: that is, it is now possible to run a comptuational verification study directly in a PDF, thereby allowing a technical author to report numerical subtleties that traditionally have been ignored. The motivation for this document-centric approach is discussed elsewhere (Quirk2003, Adaptive Mesh Refinement Theory and Practice, Springer), leaving the talk to concentrate on specific detonation examples that should be of broad interest to the shock-compression community.

  2. Microwave Diagnostics of Shock Wave and Detonation Processes

    Science.gov (United States)

    Mikhaylov, Anatoly; Belsky, Vladimir; Bogdanov, Evgeny; Rodionov, Alexey; Sedov, Alexander; Khvorostin, Vladimir; Russian Federal Nuclear Center-Vniief 607190, Sarov, Nizhniy Novgorod Reg., Russia Team

    2013-06-01

    The physical bases of laser and microwave Doppler interferometry are the same - measurements of the Doppler shift of probing electromagnetic frequency, reflected from a moving surface. However, using probing wavelength 4 orders of magnitude longer, microwave diagnostics has some specific advantages as compared with laser diagnostics, namely: measurements inside the microwave-transparent media, which spectrum is much more wide than the spectrum of optically transparent media; for microwave measurements the reflecting surfaces of media, but all jumps of medium parameters - density, dielectric permittivity, conductivity; for microwave technique due to its wavelength all practically important hydrodynamical jumps are smooth. The results of application of the microwave technique were presented in the paper, which demonstrate capabilities of diagnostics of various dynamic processes using single equipment, namely: liners and massive objects launching; shock-to-detonation transition in HE; propagation of steady detonation waves; laminar HE combustion etc. In all conducted investigations the using of the microwave technique gives a big amount of interesting experimental information which is inaccessible for the other traditional experimental techniques.

  3. Modeling the kinetics of carbon coagulation in explosives detonation

    Science.gov (United States)

    Ree, F. H.; Viecelli, J. A.; Glosli, J. N.

    1998-05-01

    A typical insensitive high explosive such as LX-17 has a large carbon content. The detonation behavior of these explosives is affected by a slow coagulation of carbon atoms by diffusion and their possible transformation from one chemical bonding type to another. We have used the Brenner bond order potential to compute the melting line of diamond at high pressure and high temperature by molecular dynamics and Monte Carlo simulations, with the goal to refine the potential for the study of the kinetics of the graphite diamond transition. The slow diffusion-controlled kinetics of carbon clusters has been examined by including a time-dependent surface correction to the Gibbs free energy of these clusters in the nonequilibrium CHEQ code. We also propose a new explosive burn model which incorporates a partial release of the heat of detonation in a fast reaction zone, followed by a diffusion-limited release of the remaining energy. Hydrodynamic applications of the new burn model to LX-17 show that computed expansion and compression results both agree closely with experimental data.

  4. The measured temperature and pressure of EDC37 detonation products

    Science.gov (United States)

    Ferguson, J. W.; Richley, J. C.; Sutton, B. D.; Price, E.; Ota, T. A.

    2017-01-01

    We present the experimentally determined temperature and pressure of the detonation products of EDC37; a HMX based conventional high explosive. These measurements were performed on a series of cylinder tests. The temperature measurements were undertaken at the end of the cylinder with optical fibres observing the bare explosive through a LiF window. The temperature of the products was measured for approximately 2 µs using single colour pyrometry, multicolour pyrometry and also using time integrated optical emission spectroscopy with the results from all three methods being broadly consistent. The peak temperature was found to be ≈ 3600 K dropping to ≈ 2400 K at the end of the measurement window. The spectroscopy was time integrated and showed that the emission spectra can be approximated using a grey body curve between 520 - 800 nm with no emission or absorption lines being observed. The pressure was obtained using an analytical method which requires the velocity of the expanding cylinder wall and the velocity of detonation. The pressure drops from an initial CJ value of ≈ 38 GPa to ≈ 4 GPa after 2 µs.

  5. Molecular-dynamics study of detonation. II. The reaction mechanism

    Science.gov (United States)

    Rice, Betsy M.; Mattson, William; Grosh, John; Trevino, S. F.

    1996-01-01

    In this work, we investigate mechanisms of chemical reactions that sustain an unsupported detonation. The chemical model of an energetic crystal used in this study consists of heteronuclear diatomic molecules that, at ambient pressure, dissociate endothermically. Subsequent association of the products to form homonuclear diatomic molecules provides the energy release that sustains the detonation. A many-body interaction is used to simulate changes in the electronic bonding as a function of local atomic environment. The consequence of the many-body interaction in this model is that the intramolecular bond is weakened with increasing density. The mechanism of the reaction for this model was extracted by investigating the details of the molecular properties in the reaction zone with two-dimensional molecular dynamics. The mechanism for the initiation of the reaction in this model is pressure-induced atomization. There was no evidence of excitation of vibrational modes to dissociative states. This particular result is directly attributable to the functional form and choice of parameters for this model, but might also have more general applicability.

  6. Initiation of Detonation in Explosives by Impact of Projectiles

    Directory of Open Access Journals (Sweden)

    H.S. Yadav

    2006-04-01

    Full Text Available This paper presents a study of initiation of detonation in explosives by the impact ofprojectiles. The shock wave produced by the impact of projectiles has been considered as thestimulus for initiation of detonation. Three types of projectiles, namely (i flyer plate, (ii flatendedrod, and (iii round-ended rod or a shaped charge jet, have been considered to impact andproduce a shock wave in the explosives. Deriving relations for the parameters of impact-generatedshock wave in the explosives and projectiles, and the sound velocity in the compressed explosives,it has been shown that the difference of kinetic energy of the flyer plate before and after theimpact, which is equal to the total energy of the shock wave in the explosives, leads to criticalenergy criterion for shock initiation of explosives. In this study, the critical criterion has beenused to derive the relations for initiation of explosives by a shaped charge jet, Vj2 D = K0 , whereV j and D denote the velocity and diameter of the jet, and K0 is a constant of the explosive.

  7. Quantum Phenomena in Ignition and Detonation at Elevated Density

    Science.gov (United States)

    Drakon, A. V.; Emelianov, A. V.; Eremin, A. V.; Gurentsov, E. V.; Petrushevich, Yu. V.; Starostin, A. N.; Taran, M. D.; Fortov, V. E.

    2012-11-01

    The influence of quantum effects on the processes of initiation of combustion and detonation of hydrogen and acetylene near the low-temperature limits at elevated pressures is analyzed. A theoretical consideration which allows quantification of the quantum corrections to the rate constants of endothermic reactions associated with an increase in the high-energy tail of the equilibrium momentum distribution function at high pressures is presented. This quantum effect is caused by a manifestation of the principle of uncertainty for the energy of the colliding particles at a high frequency of collisions. It is shown that significant deviations of experimentally observed ignition and detonation delay time from the predictions of kinetic calculations are quite well described by the proposed quantum corrections. This general mechanism should be considered in the safety problem with emergency emissions of hydrogen at nuclear power stations, as well as problems of the safe production and storage of hydrogen and acetylene, which have a fundamental importance for industry and power engineering.

  8. Detonation Output Properties of D-shape Structure

    Directory of Open Access Journals (Sweden)

    Ji-feng WEI

    2014-09-01

    Full Text Available The detonation wave propagation and output properties have been analyzed for D-shape structure. Four initiation modes were designed to compare wavefront profiles and output pressure distribution. Simulation results show that three-array-nine-point initiation mode (Mode-III brings about the most match-up wave front for D-shape structure. Detonation output properties have great influence on fragment ejection velocity and distribution density. The statistical results reveal that fragment parameters of Mode-III are the largest. Compared with Mode-III, the kinetic energies of other three modes decrease by 31.6 per cent, 19.6 per cent, 4.5 per cent, respectively. The computational values and normal curve of fragments distribution are obtained. From these analyses, it can be concluded that initiation mode has great influence on output parameters of fragments. With the optimal initiation Mode-III, ideal hitting angle should be within the range of -10° to 10°, the probability of distribution density would be close to 70 per cent.Defence Science Journal, Vol. 64, No. 5, September 2014, pp.484-489, DOI:http://dx.doi.org/10.14429/dsj.64.4746

  9. Near-limit propagation of gaseous detonations in narrow annular channels

    Science.gov (United States)

    Gao, Y.; Ng, H. D.; Lee, J. H. S.

    2017-03-01

    New results on the near-limit behaviors of gaseous detonations in narrow annular channels are reported in this paper. Annular channels of widths 3.2 and 5.9 mm were made using circular inserts in a 50.8 mm-diameter external tube. The length of each annular channel was 1.8 m. Detonations were initiated in a steel driver tube where a small volume of a sensitive C2H2+ 2.5O2 mixture was injected to facilitate detonation initiation. A 2 m length of circular tube with a 50.8 mm diameter preceded the annular channel so that a steady Chapman-Jouguet (CJ) detonation was established prior to entering the annular channel. Four detonable mixtures of C2H2 {+} 2.5O2 {+} 85 % Ar, C2H2 {+} 2.5O2 {+} 70 % Ar, C3H8 {+} 5O2, and CH4 {+} 2O2 were used in the present study. Photodiodes spaced 10 cm throughout the length of both the annular channel and circular tube were used to measure the detonation velocity. In addition, smoked foils were inserted into the annular channel to monitor the cellular structure of the detonation wave. The results show that, well within the detonability limits, the detonation wave propagates along the channel with a small local velocity fluctuation and an average global velocity can be deduced. The average detonation velocity has a small deficit of 5-15 % far from the limits and the velocity rapidly decreases to 0.7V_{CJ}-0.8V_{CJ} when the detonation propagates near the limit. Subsequently, the fluctuation of local velocity also increases as the decreasing initial pressure approaches the limit. In the two annular channels used in this work, no galloping detonations were observed for both the stable and unstable mixtures tested. The present study also confirms that single-headed spinning detonation occurs at the limit, as in a circular tube, rather than the up and down "zig zag" mode in a two-dimensional, rectangular channel.

  10. Spacetime replication of continuous variable quantum information

    Science.gov (United States)

    Hayden, Patrick; Nezami, Sepehr; Salton, Grant; Sanders, Barry C.

    2016-08-01

    The theory of relativity requires that no information travel faster than light, whereas the unitarity of quantum mechanics ensures that quantum information cannot be cloned. These conditions provide the basic constraints that appear in information replication tasks, which formalize aspects of the behavior of information in relativistic quantum mechanics. In this article, we provide continuous variable (CV) strategies for spacetime quantum information replication that are directly amenable to optical or mechanical implementation. We use a new class of homologically constructed CV quantum error correcting codes to provide efficient solutions for the general case of information replication. As compared to schemes encoding qubits, our CV solution requires half as many shares per encoded system. We also provide an optimized five-mode strategy for replicating quantum information in a particular configuration of four spacetime regions designed not to be reducible to previously performed experiments. For this optimized strategy, we provide detailed encoding and decoding procedures using standard optical apparatus and calculate the recovery fidelity when finite squeezing is used. As such we provide a scheme for experimentally realizing quantum information replication using quantum optics.

  11. Modeling inhomogeneous DNA replication kinetics.

    Directory of Open Access Journals (Sweden)

    Michel G Gauthier

    Full Text Available In eukaryotic organisms, DNA replication is initiated at a series of chromosomal locations called origins, where replication forks are assembled proceeding bidirectionally to replicate the genome. The distribution and firing rate of these origins, in conjunction with the velocity at which forks progress, dictate the program of the replication process. Previous attempts at modeling DNA replication in eukaryotes have focused on cases where the firing rate and the velocity of replication forks are homogeneous, or uniform, across the genome. However, it is now known that there are large variations in origin activity along the genome and variations in fork velocities can also take place. Here, we generalize previous approaches to modeling replication, to allow for arbitrary spatial variation of initiation rates and fork velocities. We derive rate equations for left- and right-moving forks and for replication probability over time that can be solved numerically to obtain the mean-field replication program. This method accurately reproduces the results of DNA replication simulation. We also successfully adapted our approach to the inverse problem of fitting measurements of DNA replication performed on single DNA molecules. Since such measurements are performed on specified portion of the genome, the examined DNA molecules may be replicated by forks that originate either within the studied molecule or outside of it. This problem was solved by using an effective flux of incoming replication forks at the model boundaries to represent the origin activity outside the studied region. Using this approach, we show that reliable inferences can be made about the replication of specific portions of the genome even if the amount of data that can be obtained from single-molecule experiments is generally limited.

  12. Stress responses and replication of plasmids in bacterial cells

    Directory of Open Access Journals (Sweden)

    Wegrzyn Alicja

    2002-05-01

    Full Text Available Abstract Plasmids, DNA (or rarely RNA molecules which replicate in cells autonomously (independently of chromosomes as non-essential genetic elements, play important roles for microbes grown under specific environmental conditions as well as in scientific laboratories and in biotechnology. For example, bacterial plasmids are excellent models in studies on regulation of DNA replication, and their derivatives are the most commonly used vectors in genetic engineering. Detailed mechanisms of replication initiation, which is the crucial process for efficient maintenance of plasmids in cells, have been elucidated for several plasmids. However, to understand plasmid biology, it is necessary to understand regulation of plasmid DNA replication in response to different environmental conditions in which host cells exist. Knowledge of such regulatory processes is also very important for those who use plasmids as expression vectors to produce large amounts of recombinant proteins. Variable conditions in large-scale fermentations must influence replication of plasmid DNA in cells, thus affecting the efficiency of recombinant gene expression significantly. Contrary to extensively investigated biochemistry of plasmid replication, molecular mechanisms of regulation of plasmid DNA replication in response to various environmental stress conditions are relatively poorly understood. There are, however, recently published studies that add significant data to our knowledge on relations between cellular stress responses and control of plasmid DNA replication. In this review we focus on plasmids derived from bacteriophage λ that are among the best investigated replicons. Nevertheless, recent results of studies on other plasmids are also discussed shortly.

  13. An Inadvertent Concurrent Replication: Same Roadmap, Different Journey

    Science.gov (United States)

    Lemons, Christopher J.; King, Seth A.; Davidson, Kimberly A.; Berryessa, Teresa L.; Gajjar, Shimul A.; Sacks, Lia H.

    2016-01-01

    Replication is a critical aspect of scientific inquiry that presents a variety of challenges to researchers, even under the best of conditions. We conducted a review of replication rates in special education journals similar to the review conducted by Makel et al. in this issue. Unknowingly conducting independent reviews allowed for an unexpected…

  14. No double detonations but core carbon ignitions in high-resolution, grid-based simulations of binary white dwarf mergers

    CERN Document Server

    Fenn, D; Gawryszczak, A

    2016-01-01

    We study the violent phase of the merger of massive binary white dwarf systems. Our aim is to characterize the conditions for explosive burning to occur, and identify a possible explosion mechanism of Type Ia supernovae. The primary components of our model systems are carbon-oxygen (C/O) white dwarfs, while the secondaries are made either of C/O or of pure helium. We account for tidal effects in the initial conditions in a self-consistent way, and consider initially well-separated systems with slow inspiral rates. We study the merger evolution using an adaptive mesh refinement, reactive, Eulerian code in three dimensions, assuming symmetry across the orbital plane. We use a co-rotating reference frame to minimize the effects of numerical diffusion, and solve for self-gravity using a multi-grid approach. We find a novel detonation mechanism in C/O mergers with massive primaries. Here the detonation occurs in the primary's core and relies on the combined action of tidal heating, accretion heating, and self-heat...

  15. Asymmetry and the Nucleosynthetic Signature of Nearly Edge-Lit Detonation in White Dwarf Cores

    CERN Document Server

    Chamulak, David A; Seitenzahl, Ivo R; Truran, James W

    2011-01-01

    Most of the leading explosion scenarios for Type Ia supernovae involve the nuclear incineration of a white dwarf star through a detonation wave. Several scenarios have been proposed as to how this detonation may actually occur, but the exact mechanism and environment in which it takes place remain unknown. We explore the effects of an off-center initiated detonation on the spatial distribution of the nucleosynthetic yield products in a toy model - a pre-expanded near Chandrasekhar-mass white dwarf. We find that a single near edge-lit detonation results in asymmetries in the density and thermal profiles, notably the expansion timescale, throughout the supernova. We demonstrate that this asymmetry of the thermodynamic trajectories should be common to off-center detonations where a small amount of the star is burned prior to detonation. The asymmetry stems from the fact that in one hemisphere the propagation direction of the detonation wave is largely in the direction of final (radial) expansion, whereas in the ...

  16. Simulation of detonation of ammonium nitrate fuel oil mixture confined by aluminum: edge angles for DSD

    Energy Technology Data Exchange (ETDEWEB)

    Short, Mark [Los Alamos National Laboratory; Quirk, James J [Los Alamos National Laboratory; Kiyanda, Charles B [Los Alamos National Laboratory; Jackson, Scott I [Los Alamos National Laboratory; Briggs, Matthew E [Los Alamos National Laboratory; Shinas, Micheal A [Los Alamos National Laboratory

    2010-01-01

    Non-ideal high explosives are typically porous, low-density materials with a low detonation velocity (3--5 km/s) and long detonation reaction zone ({approx} cms). As a result, the interaction of a non-ideal high explosive with an inert confiner can be markedly different than for a conventional high explosive. Issues arise, for example, with light stiff confiners where the confiner can drive the high explosive (HE) through a Prandtl-Meyer fan at the HE/confiner interface rather than the HE driving the confiner. For a non-ideal high explosive confined by a high sound speed inert such that the detonation velocity is lower than the inert sound speed, the flow is subsonic and thus shockless in the confiner. In such cases, the standard detonation shock dynamics methodology, which requires a positive edge-angle be specified at the HE/confiner interface in order that the detonation shape be divergent, cannot be directly utilized. In order to study how detonation shock dynamics can be utilized in such cases, numerical simulations of the detonation of ammonium nitrate-fuel oil (ANFO) confined by aluminum 6061 are conducted.

  17. On the neutralization of bacterial spores in post-detonation flows

    Science.gov (United States)

    Gottiparthi, K. C.; Schulz, J. C.; Menon, S.

    2014-09-01

    In multiple operational scenarios, explosive charges are used to neutralize confined or unconfined stores of bacterial spores. The spore destruction is achieved by post-detonation combustion and mixing of hot detonation product gases with the ambient flow and spore clouds. In this work, blast wave interaction with bacterial spore clouds and the effect of post-detonation combustion on spore neutralization are investigated using numerical simulations. Spherical explosive charges (radius, = 5.9 cm) comprising of nitromethane are modeled in the vicinity of a spore cloud, and the spore kill in the post-detonation flow is quantified. The effect of the mass of the spores and the initial distance, , of the spore cloud from the explosive charge on the percentage of spores neutralized is investigated. When the spores are initially placed within a distance of 3.0, within 0.1 ms after detonation of the charge, all the spores are neutralized by the blast wave and the hot detonation product gases. In contrast, almost all the spores survived the explosion when is greater than 8.0. The percentage of intact spores varied from 0 to 100 for 3.0 8.0 with spore neutralization dependent on time spent by the spores in the post-detonation mixing/combustion zone.

  18. Development and qualification testing of a laser-ignited, all-secondary (DDT) detonator

    Science.gov (United States)

    Blachowski, Thomas J.; Krivitsky, Darrin Z.; Tipton, Stephen

    1994-01-01

    The Indian Head Division, Naval Surface Warfare Center (IHDIV, NSWC) is conducting a qualification program for a laser-ignited, all-secondary (DDT) explosive detonator. This detonator was developed jointly by IHDIV, NSWC and the Department of Energy's EG&G Mound Applied Technologies facility in Miamisburg, Ohio to accept a laser initiation signal and produce a fully developed shock wave output. The detonator performance requirements were established by the on-going IHDIV, NSWC Laser Initiated Transfer Energy Subsystem (LITES) advanced development program. Qualification of the detonator as a component utilizing existing military specifications is the selected approach for this program. The detonator is a deflagration-to-detonator transfer (DDT) device using a secondary explosive, HMX, to generate the required shock wave output. The prototype development and initial system integration tests for the LITES and for the detonator were reported at the 1992 International Pyrotechnics Society Symposium and at the 1992 Survival and Flight Equipment National Symposium. Recent results are presented for the all-fire sensitivity and qualification tests conducted at two different laser initiation pulses.

  19. Unsteady self-sustained detonation waves in flake aluminum dust/air mixtures

    CERN Document Server

    Liu, Qingming; Zhang, Yunming; Li, Shuzhuan

    2015-01-01

    Self-sustained detonation waves in flake aluminum dust/air mixtures have been studied in a tube of diameter 199 mm and length 32.4 m. A pressure sensor array of 32 sensors mounted around certain circumferences of the tube was used to measure the shape of the detonation front in the circumferential direction and pressure histories of the detonation wave. A two-head spin detonation wave front was observed for the aluminum dust/air mixtures, and the cellular structure resulting from the spinning movement of the triple point was analyzed. The variations in velocity and overpressure of the detonation wave with propagation distance in a cell were studied. The interactions of waves in triple-point configurations were analyzed and the flow-field parameters were calculated. Three types of triple-point configuration exist in the wave front of the detonation wave of an aluminum dust/air mixture. Both strong and weak transverse waves exist in the unstable self-sustained detonation wave.

  20. Deflagration-to-detonation transition project: quarterly report for the period September through November 1979

    Energy Technology Data Exchange (ETDEWEB)

    Lieberman, M. L. [ed.

    1980-07-01

    The activities of the Sandia Laboratories project on deflagration-to-detonation transition (DDT) pertain primarily to the development of small, safe, low-voltage, hot-wire detonators. Its major goals are: the formulation of a modeling capability for DDT of the explosive 2-(5-cyanotetrazolato)pentaamminecobalt(III) perchlorate (CP); the development of improved DDT materials; the establishment of a data base for corrosion, compatibility, and reliability of CP-loaded detonators; and the design and development of advanced DDT components. Progress in this research is reported. The planned development of the MC3423 detonator has been completed and the final design review meeting has been held. Additional work must be performed to establish satisfactory output function. Ignition sensitivity data have also been obtained. Ignition and shock testing experiments for development of the MC3533 detonator have been planned. An initial version of the component will utilize available MC3423 headers, while the final design will incorporate a new header that has been designed and ordered. Detonator performance studies have been planned to optimize CP density-length factors. Feasibility studies on the MC3196A detonator have continued in an effort to obtain a reliable 50-200 ..mu..s function time.

  1. Ignition and growth modeling of detonation reaction zone experiments on single crystals of PETN and HMX

    Science.gov (United States)

    White, Bradley W.; Tarver, Craig M.

    2017-01-01

    It has long been known that detonating single crystals of solid explosives have much larger failure diameters than those of heterogeneous charges of the same explosive pressed or cast to 98 - 99% theoretical maximum density (TMD). In 1957, Holland et al. demonstrated that PETN single crystals have failure diameters of about 8 mm, whereas heterogeneous PETN charges have failure diameters of less than 0.5 mm. Recently, Fedorov et al. quantitatively determined nanosecond time resolved detonation reaction zone profiles of single crystals of PETN and HMX by measuring the interface particle velocity histories of the detonating crystals and LiF windows using a PDV system. The measured reaction zone time durations for PETN and HMX single crystal detonations were approximately 100 and 260 nanoseconds, respectively. These experiments provided the necessary data to develop Ignition and Growth (I&G) reactive flow model parameters for the single crystal detonation reaction zones. Using these parameters, the calculated unconfined failure diameter of a PETN single crystal was 7.5 +/- 0.5 mm, close to the 8 mm experimental value. The calculated failure diameter of an unconfined HMX single crystal was 15 +/- 1 mm. The unconfined failure diameter of an HMX single crystal has not yet been determined precisely, but Fedorov et al. detonated 14 mm diameter crystals confined by detonating a HMX-based plastic bonded explosive (PBX) without initially overdriving the HMX crystals.

  2. Particle temperature measurements in closed chamber detonations using thermoluminescence from Li{sub 2}B{sub 4}O{sub 7}:Ag,Cu, MgB{sub 4}O{sub 7}:Dy,Li and CaSO{sub 4}:Ce,Tb

    Energy Technology Data Exchange (ETDEWEB)

    Yukihara, E.G., E-mail: eduardo.yukihara@okstate.edu [Physics Department, Oklahoma State University, 145 Physical Sciences, Stillwater, OK 74078 (United States); Coleman, A.C.; Bastani, S.; Gustafson, T. [Physics Department, Oklahoma State University, 145 Physical Sciences, Stillwater, OK 74078 (United States); Talghader, J.J. [Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455 (United States); Daniels, A.; Stamatis, D.; Lightstone, J. M; Milby, C.; Svingala, F.R. [Naval Surface Warfare Center, Indian Head Explosive Ordnance Disposal Technology Division (NSWC IHEODTD), Indian Head, MD 20640 (United States)

    2015-09-15

    The present work describes the procedures and results from the first temperature measurements in closed chamber detonations obtained using the thermoluminescence (TL) of particles specifically developed for temperature sensing. Li{sub 2}B{sub 4}O{sub 7}:Ag,Cu (LBO), MgB{sub 4}O{sub 7}:Dy,Li (MBO) and CaSO{sub 4}:Ce,Tb (CSO) were tested separately in a total of 12 independent detonations using a closed detonation chamber at the Naval Surface Warfare Center, Indian Head Explosive Ordnance Disposal Technology Division (NSWC IHEODTD). Detonations were carried out using two different explosives: a high temperature plastic bonded explosive (HPBX) and a low temperature plastic bonded explosive (LPBX). The LPBX and HPBX charges produced temperatures experienced by the TL particles to be between ~550–670 K and ~700–780 K, respectively, depending on the shot. The measured temperatures were reproducible and typically higher than the thermocouple temperatures. These tests demonstrate the survivability of the TL materials and the ability to obtain temperature estimates in realistic conditions, indicating that TL may represent a reliable way of estimating the temperature experienced by free-flowing particles inside an opaque post-detonation fireball. - Highlights: • TL materials were tested in closed chamber detonations. • Temperatures experienced by the particles were ~550–670 K and ~700–780 K. • TL temperatures were reproducible and higher than thermocouple measurements. • Tests demonstrate TL material survival and ability to obtain temperature estimates.

  3. Replicated Spectrographs in Astronomy

    CERN Document Server

    Hill, Gary J

    2014-01-01

    As telescope apertures increase, the challenge of scaling spectrographic astronomical instruments becomes acute. The next generation of extremely large telescopes (ELTs) strain the availability of glass blanks for optics and engineering to provide sufficient mechanical stability. While breaking the relationship between telescope diameter and instrument pupil size by adaptive optics is a clear path for small fields of view, survey instruments exploiting multiplex advantages will be pressed to find cost-effective solutions. In this review we argue that exploiting the full potential of ELTs will require the barrier of the cost and engineering difficulty of monolithic instruments to be broken by the use of large-scale replication of spectrographs. The first steps in this direction have already been taken with the soon to be commissioned MUSE and VIRUS instruments for the Very Large Telescope and the Hobby-Eberly Telescope, respectively. MUSE employs 24 spectrograph channels, while VIRUS has 150 channels. We compa...

  4. SUMO and KSHV Replication

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Pei-Ching [Institute of Microbiology and Immunology, National Yang-Ming University, Taipei 112, Taiwan (China); Kung, Hsing-Jien, E-mail: hkung@nhri.org.tw [Institute for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan (China); Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616 (United States); UC Davis Cancer Center, University of California, Davis, CA 95616 (United States); Division of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan (China)

    2014-09-29

    Small Ubiquitin-related MOdifier (SUMO) modification was initially identified as a reversible post-translational modification that affects the regulation of diverse cellular processes, including signal transduction, protein trafficking, chromosome segregation, and DNA repair. Increasing evidence suggests that the SUMO system also plays an important role in regulating chromatin organization and transcription. It is thus not surprising that double-stranded DNA viruses, such as Kaposi’s sarcoma-associated herpesvirus (KSHV), have exploited SUMO modification as a means of modulating viral chromatin remodeling during the latent-lytic switch. In addition, SUMO regulation allows the disassembly and assembly of promyelocytic leukemia protein-nuclear bodies (PML-NBs), an intrinsic antiviral host defense, during the viral replication cycle. Overcoming PML-NB-mediated cellular intrinsic immunity is essential to allow the initial transcription and replication of the herpesvirus genome after de novo infection. As a consequence, KSHV has evolved a way as to produce multiple SUMO regulatory viral proteins to modulate the cellular SUMO environment in a dynamic way during its life cycle. Remarkably, KSHV encodes one gene product (K-bZIP) with SUMO-ligase activities and one gene product (K-Rta) that exhibits SUMO-targeting ubiquitin ligase (STUbL) activity. In addition, at least two viral products are sumoylated that have functional importance. Furthermore, sumoylation can be modulated by other viral gene products, such as the viral protein kinase Orf36. Interference with the sumoylation of specific viral targets represents a potential therapeutic strategy when treating KSHV, as well as other oncogenic herpesviruses. Here, we summarize the different ways KSHV exploits and manipulates the cellular SUMO system and explore the multi-faceted functions of SUMO during KSHV’s life cycle and pathogenesis.

  5. Study of Detonation Wave Structure in Solid and Liquid Tetranitromethane (TNM)

    Science.gov (United States)

    Fedorov, A. V.; Mikhailov, A. L.; Nazarov, D. V.; Finyushin, S. A.; Men'shikh, A. V.; Davydov, V. A.; Govorunova, T. A.

    2006-07-01

    Investigations of detonation front structure and parameters in solid and liquid tetranitromethane were done using Doppler Fabry-Perot velocimeter. We recorded the particle velocity of explosion products, braking on the HE/window interface. Smooth front of the detonation wave and concave negative-going particle velocity profile were recorded for liquid TNM. The experimental records indicate that because of solid TNM heterogeneity flow, turbulization occurs behind detonation wave front what appears in the form of velocity fluctuations on the U(t) profile.

  6. Simulation of Gas Detonation Propagation in a Medium Having Variable Chemical Composition

    Science.gov (United States)

    Prokhorov, E. S.

    2017-01-01

    Within the framework of a quasi-one-dimensional approximation, a mathematical model of the propagation of a detonation wave in a tube filled with explosive gas mixture with spatially variable chemical composition has been formulated, and the respective problem has been solved numerically. The shift in the chemical equilibrium of detonation products as well as the friction and heat removal losses were taken into account. The proposed mathematical model allows one to describe steady-state (of Chapman-Jouguet) and over-compressed detonation regimes.

  7. Computer Modeling of a Rotating Detonation Engine in a Rocket Configuration

    Science.gov (United States)

    2015-03-01

    coefficient CP Specific heat capacity at constant pressure ( J kg−K ) CS Nozzle stream thrust coefficient D Detonation wave speed in laboratory frame-of...greater than the detonation fuel-to-air ratio, the ratio of specific heats and gas constant at station c3.4 are calculated using Eq. 75 and Eq. 76...COMPUTER MODELING OF A ROTATING DETONATION ENGINE IN A ROCKET CONFIGURATION THESIS Nihar N. Shah, 1st Lt, USAF AFIT-ENY-MS-15-M-230 DEPARTMENT OF THE

  8. Analysis of trapped gas in 1E34 detonators by gas chromatography

    Energy Technology Data Exchange (ETDEWEB)

    Warner, D.K.; Back, P.S.; Barnhart, B.V.

    1980-05-14

    A method was developed to extract and then analyze gas trapped in thermally aged 1E34 detonators. This gas was extracted into an evacuated volume and injected into a gas chromatograph for separation and quantitative analysis. To effect this gas extraction, a device was designed for puncturing the detonator cup and capturing the effused gas. Limited testing of five detonators in this device shows amounts of gas ranging from about 0.5 X 10 {sup -7} to 12 X 10 {sup - 7} moles.

  9. MC3644 detonator development status report for the period ending October 30, 1981

    Energy Technology Data Exchange (ETDEWEB)

    Jacobson, A.K.

    1982-01-01

    The MC3644 detonator is being developed as a replacement for the MC3132 flying plate detonator in the parachute deployment system of the B83 weapon. The MC3644 is a CP, deflagration-to-detonation transition device. Two models are being developed: an interim design using the MC3423 ignitor and a new production version with a one-piece ignitor/header assembly. Features of both designs are described. Results of development tests involving the interim design are presented. No-fire sensitivity test and proof-test results with the WR version are also included. The development program is on schedule.

  10. Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase

    Science.gov (United States)

    Lõoke, Marko; Maloney, Michael F.; Bell, Stephen P.

    2017-01-01

    Activation of the Mcm2–7 replicative DNA helicase is the committed step in eukaryotic DNA replication initiation. Although Mcm2–7 activation requires binding of the helicase-activating proteins Cdc45 and GINS (forming the CMG complex), an additional protein, Mcm10, drives initial origin DNA unwinding by an unknown mechanism. We show that Mcm10 binds a conserved motif located between the oligonucleotide/oligosaccharide fold (OB-fold) and A subdomain of Mcm2. Although buried in the interface between these domains in Mcm2–7 structures, mutations predicted to separate the domains and expose this motif restore growth to conditional-lethal MCM10 mutant cells. We found that, in addition to stimulating initial DNA unwinding, Mcm10 stabilizes Cdc45 and GINS association with Mcm2–7 and stimulates replication elongation in vivo and in vitro. Furthermore, we identified a lethal allele of MCM10 that stimulates initial DNA unwinding but is defective in replication elongation and CMG binding. Our findings expand the roles of Mcm10 during DNA replication and suggest a new model for Mcm10 function as an activator of the CMG complex throughout DNA replication. PMID:28270517

  11. Efficient usage of Adabas replication

    CERN Document Server

    Storr, Dieter W

    2011-01-01

    In today's IT organization replication becomes more and more an essential technology. This makes Software AG's Event Replicator for Adabas an important part of your data processing. Setting the right parameters and establishing the best network communication, as well as selecting efficient target components, is essential for successfully implementing replication. This book provides comprehensive information and unique best-practice experience in the field of Event Replicator for Adabas. It also includes sample codes and configurations making your start very easy. It describes all components ne

  12. Solving the Telomere Replication Problem

    Science.gov (United States)

    Maestroni, Laetitia; Matmati, Samah; Coulon, Stéphane

    2017-01-01

    Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at the ends of the chromosomes. This is known as the telomere replication problem. In this article, different and new aspects of telomere replication, that can threaten the integrity of telomeres, will be reviewed. In particular, we will focus on the functions of shelterin and the replisome for the preservation of telomere integrity. PMID:28146113

  13. 炸药爆轰参数与空中爆炸冲击波超压的关系%Relation of Air Explosion Shock Wave Overpressure and Detonation Parameters of Explosives

    Institute of Scientific and Technical Information of China (English)

    牛余雷; 冯晓军; 李媛媛; 南海; 郭昕

    2013-01-01

    为研究炸药爆轰参数与空中爆炸冲击波超压之间的关系,设计了不同铝含量的RDX/Al、HMX/Al混合炸药,并进行了空中爆炸试验.根据爆炸相似理论,用相同条件下实测TNT超压数据,计算了冲击波超压的TNT当量.采用不同方法计算了炸药的爆轰参数.结果表明,炸药空中爆炸冲击波超压与爆热、爆容和爆速乘积TNT当量的1/3次方满足线性关系,且回归线在y轴上的截距为0,斜率与炸药的类型有关.对于TNT,斜率为1;对于RDX/Al混合炸药,斜率为1.053(R2 =0.9996);对HMX/Al混合炸药,斜率为1.073(R2 =0.9995),表明炸药的爆热、爆速和爆容对空中爆炸冲击波超压的影响相同.%To research the relation of air explosion shock wave overpressure and detonation parameters of explosives,the RDX-based and HMX-based composite explosives with different aluminum content were designed and the air explosion experiment was performed.Based on the explosion similarity law,the TNT equivalence of shock wave overpressure was calculated using TNT explosion overpressure data measured in the same condition.The detonation parameters of explosives were calculated by different methods.The results show that there is a linear relationship between TNT equivalence of air explosion shock wave overpressure and one-third power of the TNT equivalence for the product of the detonation heat,detonation volume and detonation velocity,and the intercept of regression at y-axis is zero.The slope relates to the types of explosive.The slope is 1 for TNT,1.053(R2 =0.9996)for RDX/Al composite explosives and 1.073 (R2 =0.9995)for HMX/Al composite explosives,indicating that the detonation heat,detonation volume and detonation velocity have the same influence on air explosion shock wave overpressure.

  14. A theoretical equation of state for detonation products

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, M.S.

    1998-12-31

    A theoretical equation of state for detonation products is described that places particular emphasis on the characterization of small carbon clusters (20{angstrom}--50{angstrom} in diameter) in the products. Diamond clusters are modeled with the dangling bonds on the surface atoms (up to 30% of the cluster) capped by various radicals composed of C, H, N, and O from the background molecular fluid mixture. Free energy methods for the surface groups are used to determine the chemical equilibrium composition of the cluster surface as well as the surrounding molecular fluid mixture. The surface composition shows dramatic changes in composition over some regions and varies slowly in others. A perturbation theory approach is used for the mixture of molecular fluids that also includes features based on Monte Carlo simulations.

  15. A Simplified Model for Detonation Based Pressure-Gain Combustors

    Science.gov (United States)

    Paxson, Daniel E.

    2010-01-01

    A time-dependent model is presented which simulates the essential physics of a detonative or otherwise constant volume, pressure-gain combustor for gas turbine applications. The model utilizes simple, global thermodynamic relations to determine an assumed instantaneous and uniform post-combustion state in one of many envisioned tubes comprising the device. A simple, second order, non-upwinding computational fluid dynamic algorithm is then used to compute the (continuous) flowfield properties during the blowdown and refill stages of the periodic cycle which each tube undergoes. The exhausted flow is averaged to provide mixed total pressure and enthalpy which may be used as a cycle performance metric for benefits analysis. The simplicity of the model allows for nearly instantaneous results when implemented on a personal computer. The results compare favorably with higher resolution numerical codes which are more difficult to configure, and more time consuming to operate.

  16. Reduction of global effects on vehicles after IED detonations

    Institute of Scientific and Technical Information of China (English)

    V.DENEFELD; N.HEIDER; A.HOLZWARTH; A.S€ATTLER; M.SALK

    2014-01-01

    Global effects caused by the detonation of an IED near a military vehicle induce subsequent severe acceleration effects on the vehicle occupants. Two concepts to minimize these global effects were developed, with the help of a combined method based on a scaled experimental technology and numerical simulations. The first concept consists in the optimization of the vehicle shape to reduce the momentum transfer and thus the occupant loading. Three scaled V-shaped vehicles with different ground clearances were built and compared to a reference vehicle equipped with a flat floor. The second concept, called dynamic impulse compensation (DIC), is based on a momentum compensation technique. The principal possibility of this concept was demonstrated on a scaled vehicle. In addition, the numerical simulations have been performed with generic full size vehicles including dummy models, proving the capability of the DIC technology to reduce the occupant loading.

  17. Volume Ignition via Time-like Detonation in Pellet Fusion

    CERN Document Server

    Csernai, L P

    2015-01-01

    Relativistic fluid dynamics and the theory of relativistic detonation fronts are used to estimate the space-time dynamics of the burning of the D-T fuel in Laser driven pellet fusion experiments. The initial "High foot" heating of the fuel makes the compressed target transparent to radiation, and then a rapid ignition pulse can penetrate and heat up the whole target to supercritical temperatures in a short time, so that most of the interior of the target ignites almost simultaneously and instabilities will have no time to develop. In these relativistic, radiation dominated processes both the interior, time-like burning front and the surrounding space-like part of the front will be stable against Rayleigh-Taylor instabilities. To achieve this rapid, volume ignition the pulse heating up the target to supercritical temperature should provide the required energy in less than ~ 10 ps.

  18. Detonation performance measurements of cyclotol 80/20

    Science.gov (United States)

    Kuiper, T. A.; Anderson, E. K.; Short, M.; Jackson, S. I.

    2017-01-01

    Cyclotol is a melt-castable high explosive composed of RDX and TNT, and typically a small amount of HMX. The term Cyclotol may apply to other mixtures of these components, but for the present work, experiments were conducted using Cyclotol containing 80 wt% RDX and HMX and 20 wt% TNT (we will refer to mixtures of RDX and TNT using the notation RDX%/TNT%). In the current effort, we report detonation velocity measurements at several diameters for unconfined rate sticks. The results are compared to prior diameter-effect data for Cyclotol 77/23, and a density-corrected Eyring-form fit for all available rate-stick data is reported.

  19. Spontaneous Transition of Turbulent Flames to Detonations in Unconfined Media

    CERN Document Server

    Poludnenko, Alexei Y; Oran, Elaine S

    2011-01-01

    Deflagration-to-detonation transition (DDT) can occur in environments ranging from experimental and industrial systems to astrophysical thermonuclear (type Ia) supernovae explosions. Substantial progress has been made in explaining the nature of DDT in confined systems with walls, internal obstacles, or pre-existing shocks. It remains unclear, however, whether DDT can occur in unconfined media. Here we use direct numerical simulations (DNS) to show that for high enough turbulent intensities unconfined, subsonic, premixed, turbulent flames are inherently unstable to DDT. The associated mechanism, based on the nonsteady evolution of flames faster than the Chapman-Jouguet deflagrations, is qualitatively different from the traditionally suggested spontaneous reaction wave model, and thus does not require the formation of distributed flames. Critical turbulent flame speeds, predicted by this mechanism for the onset of DDT, are in agreement with DNS results.

  20. Influence of thermal oxidation on as-synthesized detonation nanodiamond

    Institute of Scientific and Technical Information of China (English)

    Xiangyang Xu; Zhiming Yu

    2012-01-01

    The thermal property of an as-synthesized black powder,a detonation nanodiamond (DND) product,was first analyzed,followed by thermal oxidation to modify its surface.During the thermal treatment,the non-diamond carbonaceous shell of the black powder was oxidized,with the likelihood of forming a C-O-C bonding between carbon atoms on the particle surface.This new structure may rupture with intensified oxidation through increasing the heating temperature and prolonging the process duration.As more oxygen-containing functional groups form on the particle surface,the particle surface becomes negatively charged,and the powder turns to be more hydrophilic.

  1. Characterization Of High Explosives Detonations Via Laser-Induced Plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Villa-Aleman, E. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-10-08

    One objective of the Department of Energy’s National Security Administration is to develop technologies that can help the United States government to detect foreign nuclear weapons development activities. The realm of high explosive (HE) experiments is one of the key areas to assess the nuclear ambitions of a country. SRNL has participated in the collection of particulates from HE experiments and characterized the material with the purpose to correlate particulate matter with HE. Since these field campaigns are expensive, on-demand simulated laboratory-scale explosion experiments are needed to further our knowledge of the chemistry and particle formation in the process. Our goal is to develop an experimental test bed in the laboratory to test measurement concepts and correlate particle formation processes with the observables from the detonation fireball. The final objective is to use this knowledge to tailor our experimental setups in future field campaigns. The test bed uses pulsed laser-induced plasmas to simulate micro-explosions, with the intent to study the temporal behavior of the fireball observed in field tests. During FY15, a plan was prepared and executed which assembled two laser ablation systems, procured materials for study, and tested a Step-Scan Fourier Transform Infrared Spectrometer (SS-FTIR). Designs for a shadowgraph system for shock wave analysis, design for a micro-particulate collector from ablated pulse were accomplished. A novel spectroscopic system was conceived and a prototype system built for acquisition of spectral/temporal characterization of a high speed event such as from a high explosive detonation. Experiments and analyses will continue into FY16.

  2. Multifork chromosome replication in slow-growing bacteria

    Science.gov (United States)

    Trojanowski, Damian; Hołówka, Joanna; Ginda, Katarzyna; Jakimowicz, Dagmara; Zakrzewska-Czerwińska, Jolanta

    2017-01-01

    The growth rates of bacteria must be coordinated with major cell cycle events, including chromosome replication. When the doubling time (Td) is shorter than the duration of chromosome replication (C period), a new round of replication begins before the previous round terminates. Thus, newborn cells inherit partially duplicated chromosomes. This phenomenon, which is termed multifork replication, occurs among fast-growing bacteria such as Escherichia coli and Bacillus subtilis. In contrast, it was historically believed that slow-growing bacteria (including mycobacteria) do not reinitiate chromosome replication until the previous round has been completed. Here, we use single-cell time-lapse analyses to reveal that mycobacterial cell populations exhibit heterogeneity in their DNA replication dynamics. In addition to cells with non-overlapping replication rounds, we observed cells in which the next replication round was initiated before completion of the previous replication round. We speculate that this heterogeneity may reflect a relaxation of cell cycle checkpoints, possibly increasing the ability of slow-growing mycobacteria to adapt to environmental conditions. PMID:28262767

  3. The Cell Cycle Timing of Human Papillomavirus DNA Replication.

    Science.gov (United States)

    Reinson, Tormi; Henno, Liisi; Toots, Mart; Ustav, Mart; Ustav, Mart

    2015-01-01

    Viruses manipulate the cell cycle of the host cell to optimize conditions for more efficient viral genome replication. One strategy utilized by DNA viruses is to replicate their genomes non-concurrently with the host genome; in this case, the viral genome is amplified outside S phase. This phenomenon has also been described for human papillomavirus (HPV) vegetative genome replication, which occurs in G2-arrested cells; however, the precise timing of viral DNA replication during initial and stable replication phases has not been studied. We developed a new method to quantitate newly synthesized DNA levels and used this method in combination with cell cycle synchronization to show that viral DNA replication is initiated during S phase and is extended to G2 during initial amplification but follows the replication pattern of cellular DNA during S phase in the stable maintenance phase. E1 and E2 protein overexpression changes the replication time from S only to both the S and G2 phases in cells that stably maintain viral episomes. These data demonstrate that the active synthesis and replication of the HPV genome are extended into the G2 phase to amplify its copy number and the duration of HPV genome replication is controlled by the level of the viral replication proteins E1 and E2. Using the G2 phase for genome amplification may be an important adaptation that allows exploitation of changing cellular conditions during cell cycle progression. We also describe a new method to quantify newly synthesized viral DNA levels and discuss its benefits for HPV research.

  4. Local Ignition in Carbon/Oxygen White Dwarfs -- I: One-zone Ignition and Spherical Shock Ignition of Detonations

    CERN Document Server

    Dursi, L J

    2006-01-01

    The details of ignition of Type Ia supernovae remain fuzzy, despite the importance of this input for any large-scale model of the final explosion. Here, we begin a process of understanding the ignition of these hotspots by examining the burning of one zone of material, and then investigate the ignition of a detonation due to rapid heating at single point. We numerically measure the ignition delay time for onset of burning in mixtures of degenerate material and provide fitting formula for conditions of relevance in the Type Ia problem. Using the neon abundance as a proxy for the white dwarf metallicity, we then find that ignition times can decrease by ~20% with addition of even 5% of neon by mass. When temperature fluctuations that successfully kindle a region are very rare, such a reduction in ignition time can increase the probability of ignition by orders of magnitude. We then consider the ignition of a detonation by an explosive energy input in one localized zone, eg a Sedov blast wave leading to a shock-i...

  5. Confined detonations with cylindrical and spherical symmetry; Detonaciones confinadas con simetria esferica y cilindrica

    Energy Technology Data Exchange (ETDEWEB)

    Linan, A.; Lecuona, A.

    1979-07-01

    An imploding spherical or cylindrical detonation, starting in the interface of the detonantion with an external inert media, used as a reflector, creates on it a strong shock wave moving outward from the interface. An initially weak shock wave appears in the detonated media that travels toward the center, and it could reach the detonation wave, enforcing it in its process of implosion. To describe the fluid field, the Euler s equations are solved by means of expansions valid for the early stages of the process. Isentropic of the type P/p{gamma}-K for the detonated and compressed inert media are used. For liquid or solid reflectors a more appropriate equation is used. (Author) 8 refs.

  6. Detonation Nanodiamond Toxicity in Human Airway Epithelial Cells Is Modulated by Air Oxidation

    Science.gov (United States)

    Detonational nanodiamonds (DND), a nanomaterial with an increasing range of industrial and biomedical applications, have previously been shown to induce a pro-inflammatory response in cultured human airway epithelial cells (HAEC). We now show that surface modifications induced by...

  7. OGLE-2013-SN-079: A LONELY SUPERNOVA CONSISTENT WITH A HELIUM SHELL DETONATION

    Energy Technology Data Exchange (ETDEWEB)

    Inserra, C.; Sim, S. A.; Smartt, S. J.; Nicholl, M.; Jerkstrand, A.; Chen, T.-W. [Astrophysics Research Centre, School of Mathematics and Physics, Queens University Belfast, Belfast BT7 1NN (United Kingdom); Wyrzykowski, L. [University of Warsaw, Astronomical Observatory, Al. Ujazdowskie 400-478 Warszawa (Poland); Fraser, M.; Blagorodnova, N.; Campbell, H. [Institute of Astronomy, University of Cambridge, Madingley Road, CB3 0HA Cambridge (United Kingdom); Shen, K. J. [Department of Astronomy and Theoretical Astrophysics Center, University of California, Berkeley, CA 94720 (United States); Gal-Yam, A. [Benoziyo Center for Astrophysics, Weizmann Institute of Science, 76100 Rehovot (Israel); Howell, D. A.; Valenti, S. [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Suite 102 Goleta, CA 93117 (United States); Maguire, K. [European Southern Observatory for Astronomical Research in the Southern Hemisphere (ESO), Karl-Schwarzschild-Str. 2, 85748 Garching b. Munchen (Germany); Mazzali, P.; Bersier, D. [Astrophysics Research Institute, Liverpool John Moores University, Liverpool (United Kingdom); Taubenberger, S.; Benitez-Herrera, S. [Max-Planck-Institut für Astrophysik, Karl-Schwarzschild-Str. 1, 85741 Garching (Germany); Elias-Rosa, N., E-mail: c.inserra@qub.ac.uk [INAF - Osservatorio Astronomico di Padova, Vicolo dell' Osservatorio 5, I-35122 Padova (Italy); and others

    2015-01-20

    We present observational data for a peculiar supernova discovered by the OGLE-IV survey and followed by the Public ESO Spectroscopic Survey for Transient Objects. The inferred redshift of z = 0.07 implies an absolute magnitude in the rest-frame I-band of M{sub I} ∼ –17.6 mag. This places it in the luminosity range between normal Type Ia SNe and novae. Optical and near infrared spectroscopy reveal mostly Ti and Ca lines, and an unusually red color arising from strong depression of flux at rest wavelengths <5000 Å. To date, this is the only reported SN showing Ti-dominated spectra. The data are broadly consistent with existing models for the pure detonation of a helium shell around a low-mass CO white dwarf and ''double-detonation'' models that include a secondary detonation of a CO core following a primary detonation in an overlying helium shell.

  8. Velocity of detonation at any initial density without using heat of formation of explosives.

    Science.gov (United States)

    Keshavarz, Mohammad Hossein; Mofrad, Reza Teimuri; Alamdari, Reza Fareghi; Moghadas, Mohammad Hassan; Mostofizadeh, Ali Reza; Sadeghi, Hossein

    2006-10-11

    The simplest method is introduced for reliable estimating the detonation velocity of large class of CHNO explosives based elemental composition and specific structural groups. There is no need to use heat of formation and the other experimental data for calculation of detonation velocity in the new procedure. Only elemental composition and the number of special structural groups without using heat of formation of explosive is sufficient for reliable desk calculation of detonation velocity. The results show good agreement with experimental values with respect to computed results obtained by complex computer code using BKWS and BKWR equations of state. Predicted velocities of detonation have root-mean-square (rms) percent deviation of 2.2, 5.9 and 5.3 from experimental data for new method, BKWS and BKWR equations of state, respectively.

  9. Prediction of detonation performance of CHNO and CHNOAl explosives through molecular structure.

    Science.gov (United States)

    Keshavarz, Mohammad Hossein

    2009-07-30

    A new pathway has been introduced to predict detonation pressure of CHNO and CHNOAl explosives. Although aluminized explosives can have Chapman-Jouguet detonation performance significantly different from those expected from existing thermodynamic computer codes for equilibrium and steady state calculations, new correlation can also be used here. Molecular structures of CHNO and CHNOAl explosives are the only necessary parameters that would be needed in this new scheme. There is no need to use heat of formation or any experimental data. Besides, elemental compositions of CHNO and CHNOAl explosives rather than assumed detonation products are essential input parameters. Predicted detonation pressures for CHNO explosives are compared with experimental data as well as computed results gained by complicated computer code using BKWR and BKWS equations of state so the new method shows the best results. Also, the calculated results for CHNOAl explosives indicate good agreement with the measured data as compared to estimated results of BKWS-EOS using full and partial equilibrium.

  10. Microscopic simulations of supersonic and subsonic exothermic chemical wave fronts and transition to detonation

    Science.gov (United States)

    Lemarchand, A.; Nowakowski, B.; Dumazer, G.; Antoine, C.

    2011-01-01

    We perform microscopic simulations using the direct simulation Monte Carlo approach to an exothermic chemical wave front of Fisher-Kolmogorov, Petrovsky, Piskunov-type in a one-dimensional gaseous medium. The results confirm the existence of a transition from a weak detonation or deflagration to a Chapman-Jouguet detonation wave, that we already investigated at the macroscopic scale [G. Dumazer et al., Phys. Rev. E 78, 016309 (2008)]. In the domain of weak detonation or deflagration, the discrepancy between the propagation speeds deduced from the simulations and the macroscopic balance equations of hydrodynamics is explained by two microscopic effects, the discretization of the variables, known as cutoff effect, and the departure from local equilibrium. Remarkably, the propagation speed of a Chapman-Jouguet detonation wave is not sensitive to these perturbations of microscopic origin.

  11. Fine Tuning the CJ Detonation Speed of a High Explosive products Equation of State

    Energy Technology Data Exchange (ETDEWEB)

    Menikoff, Ralph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-05-12

    For high explosive (HE) simulations, inaccuracies of a per cent or two in the detonation wave speed can result from not suficiently resolving the reaction zone width or from small inaccuracies in calibrating the products equation of state (EOS) or from variation of HE lots. More accurate detonation speeds can be obtained by ne tuning the equation of state to compensate. Here we show that two simple EOS transformations can be used to adjust the CJ detonation speed by a couple of per cent with minimal effect on the CJ release isentrope. The two transformations are (1) a shift in the energy origin and (2) a linear scaling of the speci c volume. The effectiveness of the transformations is demonstrated with simulations of the cylinder test for PBX 9502 starting with a products EOS for which the CJ detonation speed is 1 per cent too low.

  12. Multiplicity of detonation regimes in systems with a multi-peaked thermicity

    CERN Document Server

    Lau-Chapdelaine, S SM; Zhang, F; Radulescu, M I

    2015-01-01

    The study investigates detonations with multiple quasi-steady velocities that have been observed in the past in systems with multi-peaked thermicity, using Fickett's detonation analogue. A steady state analysis of the travelling wave predicts multiple states, however, all but the one with the highest velocity develop a singularity after the sonic point. Simulations show singularities are associated with a shock wave which overtakes all sonic points, establishing a detonation travelling the highest of the predicted velocities. Under a certain parameter range, the steady-state detonation can have multiple sonic points and solutions. Embedded shocks can exist behind sonic points, where they link the weak and strong solutions. Sonic points whose characteristics do not diverge are found to be unstable, and to be the source of the embedded shocks. Numerical simulations show that these shocks are only quasi stable. This is believed to be due to the reaction rates having been chosen to be independent of hydrodynamics...

  13. Modeling the mechanics of HMX detonation using a Taylor–Galerkin scheme

    Directory of Open Access Journals (Sweden)

    Adam V. Duran

    2016-05-01

    Full Text Available Design of energetic materials is an exciting area in mechanics and materials science. Energetic composite materials are used as propellants, explosives, and fuel cell components. Energy release in these materials are accompanied by extreme events: shock waves travel at typical speeds of several thousand meters per second and the peak pressures can reach hundreds of gigapascals. In this paper, we develop a reactive dynamics code for modeling detonation wave features in one such material. The key contribution in this paper is an integrated algorithm to incorporate equations of state, Arrhenius kinetics, and mixing rules for particle detonation in a Taylor–Galerkin finite element simulation. We show that the scheme captures the distinct features of detonation waves, and the detonation velocity compares well with experiments reported in literature.

  14. Detonation cell size measurements in high-temperature hydrogen-air-steam mixtures at the BNL high-temperature combustion facility

    Energy Technology Data Exchange (ETDEWEB)

    Ciccarelli, G.; Ginsberg, T.; Boccio, J.L. [and others

    1997-11-01

    The High-Temperature Combustion Facility (HTCF) was designed and constructed with the objective of studying detonation phenomena in mixtures of hydrogen-air-steam at initially high temperatures. The central element of the HTCF is a 27-cm inner-diameter, 21.3-m long cylindrical test vessel capable of being heating to 700K {+-} 14K. A unique feature of the HTCF is the {open_quotes}diaphragmless{close_quotes} acetylene-oxygen gas driver which is used to initiate the detonation in the test gas. Cell size measurements have shown that for any hydrogen-air-steam mixture, increasing the initial mixture temperature, in the range of 300K to 650K, while maintaining the initial pressure of 0.1 MPa, decreases the cell size and thus makes the mixture more detonable. The effect of steam dilution on cell size was tested in stoichiometric and off-stoichiometric (e.g., equivalence ratio of 0.5) hydrogen-air mixtures. Increasing the steam dilution in hydrogen-air mixtures at 0.1 MPa initial pressure increases the cell size, irrespective of initial temperature. It is also observed that the desensitizing effect of steam diminished with increased initial temperature. A 1-dimensional, steady-state Zel`dovich, von Neumann, Doring (ZND) model, with full chemical kinetics, has been used to predict cell size for hydrogen-air-steam mixtures at different initial conditions. Qualitatively the model predicts the overall trends observed in the measured cell size versus mixture composition and initial temperature and pressure. It was found that the proportionality constant used to predict detonation cell size from the calculated ZND model reaction zone varies between 10 and 100 depending on the mixture composition and initial temperature. 32 refs., 35 figs.

  15. Charter School Replication. Policy Guide

    Science.gov (United States)

    Rhim, Lauren Morando

    2009-01-01

    "Replication" is the practice of a single charter school board or management organization opening several more schools that are each based on the same school model. The most rapid strategy to increase the number of new high-quality charter schools available to children is to encourage the replication of existing quality schools. This policy guide…

  16. A report on the deflagration-to-detonation transition (DDT) in the high explosive LX-04

    Energy Technology Data Exchange (ETDEWEB)

    Hare, D E; Forbes, J W; Garcia, F; Granholm, R H; Tarver, C M; Vandersall, K S; Sandusky, H W

    2004-06-30

    The deflagration-to-detonation transition (DDT) was investigated for 1.874 g/cc (98.8 % of theoretical maximum density) LX-04 in moderate confinement (4340 steel tube at R{sub C} 32 with 1.020 inch inside diameter and 0.235 inch thick wall) at both ambient initial temperature (roughly 20 C) and at an initial temperature of 186 C. No transition to detonation was observed in a 295 mm column length for either case.

  17. Simulation of the initiation of detonation in an energetic molecular crystal

    Science.gov (United States)

    Tsai, D. H.; Trevino, S. F.

    1984-12-01

    A molecular dynamical study of the detonation process in a dense system is presented. The model is a filament of a molecular crystal capable of undergoing exothermic dissociation. When the model is heated at one end, dissociation reactions start at that end and propagate along the filament. The accompanying expansion of the heated region drives a shock wave into the filament, causing further reactions due to shock heating. The results thus obtained provide a molecular description of the initiation of detonation.

  18. The corrosion resistance of zinc coatings in the presence of boron-doped detonation nanodiamonds (DND)

    Science.gov (United States)

    Burkat, G. K.; Alexandrova, G. S.; Dolmatov, V. Yu; Osmanova, E. D.; Myllymäki, V.; Vehanen, A.

    2017-02-01

    The effect of detonation nanodiamonds, doped with boron (boron-DND) in detonation synthesis on the process of zinc electrochemical deposition from zincate electrolyte is investigated. It is shown that the scattering power (coating uniformity) increases 2-4 times (depending on the concentration of DND-boron electrolyte conductivity does not change, the corrosion resistance of Zn- DND -boron coating increases 2.6 times in 3% NaCl solution (corrosion currents) and 3 times in the climatic chamber.

  19. A stabilization mechanism for the low-velocity gaseous detonations with losses

    Science.gov (United States)

    Kasimov, Aslan; Sow, Aliou; Semenko, Roman

    2016-11-01

    Using the reactive Euler equations, we investigate numerically the nonlinear stability of steady-state one-dimensional gaseous detonations in the presence of both momentum and heat losses. Our results point to a possible stabilization mechanism for the low-velocity detonations in such systems. The mechanism stems from the existence of a one-parameter family of steady-state solutions found in Semenko et al..

  20. LHCb experience with LFC replication

    CERN Document Server

    Bonifazi, F; Perez, E D; D'Apice, A; dell'Agnello, L; Düllmann, D; Girone, M; Re, G L; Martelli, B; Peco, G; Ricci, P P; Sapunenko, V; Vagnoni, V; Vitlacil, D

    2008-01-01

    Database replication is a key topic in the framework of the LHC Computing Grid to allow processing of data in a distributed environment. In particular, the LHCb computing model relies on the LHC File Catalog, i.e. a database which stores information about files spread across the GRID, their logical names and the physical locations of all the replicas. The LHCb computing model requires the LFC to be replicated at Tier-1s. The LCG 3D project deals with the database replication issue and provides a replication service based on Oracle Streams technology. This paper describes the deployment of the LHC File Catalog replication to the INFN National Center for Telematics and Informatics (CNAF) and to other LHCb Tier-1 sites. We performed stress tests designed to evaluate any delay in the propagation of the streams and the scalability of the system. The tests show the robustness of the replica implementation with performance going much beyond the LHCb requirements.

  1. DATABASE REPLICATION IN HETEROGENOUS PLATFORM

    Directory of Open Access Journals (Sweden)

    Hendro Nindito

    2014-01-01

    Full Text Available The application of diverse database technologies in enterprises today is increasingly a common practice. To provide high availability and survavibality of real-time information, a database replication technology that has capability to replicate databases under heterogenous platforms is required. The purpose of this research is to find the technology with such capability. In this research, the data source is stored in MSSQL database server running on Windows. The data will be replicated to MySQL running on Linux as the destination. The method applied in this research is prototyping in which the processes of development and testing can be done interactively and repeatedly. The key result of this research is that the replication technology applied, which is called Oracle GoldenGate, can successfully manage to do its task in replicating data in real-time and heterogeneous platforms.

  2. LHCb experience with LFC replication

    CERN Document Server

    Carbone, Angelo; Dafonte Perez, Eva; D'Apice, Antimo; dell'Agnello, Luca; Duellmann, Dirk; Girone, Maria; Lo Re, Giuseppe; Martelli, Barbara; Peco, Gianluca; Ricci, Pier Paolo; Sapunenko, Vladimir; Vagnoni, Vincenzo; Vitlacil, Dejan

    2007-01-01

    Database replication is a key topic in the framework of the LHC Computing Grid to allow processing of data in a distributed environment. In particular, the LHCb computing model relies on the LHC File Catalog, i.e. database which stores information about files spread across the GRID, their logical names and the physical locations of all the replicas. The LHCb computing model requires the LFC to be replicated at Tier-1s. The LCG 3D project deals with the database replication issue and provides a replication service based on Oracle Streams technology. This paper describes the deployment of the LHC File Catalog replication to the INFN National Center for Telematics and Informations (CNAF) and to other LHCb Tier-1 sites. We performed stress tests designed to evaluate any delay in the propagation of the streams and the scalability of the system. The tests show the robustness of the replica implementation with performance going much beyond the LHCb requirements.

  3. Experimental investigation into the detonation characteristics of hybrid RDX-ethylene-air mixtures

    Science.gov (United States)

    Yang, L.; Yao, J.; Yang, Z.; Xie, L.; Peng, J.; Rao, G.

    2016-09-01

    An experimental study is conducted to determine the detonation characteristics of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX) particles dispersed in a gaseous fuel air mixture in a vertical detonation tube with an inner diameter of 200 mm and a height of 5400 mm. Experiments are performed in both ethylene-air mixtures and RDX-ethylene-air hybrid mixtures. The detonation front pressure and velocity are measured with six pressure transducers along the detonation tube. The results show that the addition of RDX assists 4.0 vol.% ethylene-air mixtures in achieving detonation. The detonation front pressure increases noticeably with dust concentration up to 474 g/m3 in the RDX-ethylene-air hybrid mixtures, but the velocity only increases slightly. The cellular structures of RDX-ethylene-air hybrid mixtures and ethylene-air mixtures were obtained with the use of smoked foils and exhibit irregular structures. It is found that the measured cell size has a U-shaped curve with respect to RDX concentration.

  4. Laser-shocked energetic materials with metal additives: evaluation of chemistry and detonation performance.

    Science.gov (United States)

    Gottfried, Jennifer L; Bukowski, Eric J

    2017-01-20

    A focused, nanosecond-pulsed laser has been used to ablate, atomize, ionize, and excite milligram quantities of metal-doped energetic materials that undergo exothermic reactions in the laser-induced plasma. The subsequent shock wave expansion in the air above the sample has been monitored using high-speed schlieren imaging in a recently developed technique, laser-induced air shock from energetic materials (LASEM). The method enables the estimation of detonation velocities based on the measured laser-induced air-shock velocities and has previously been demonstrated for organic military explosives. Here, the LASEM technique has been extended to explosive formulations with metal additives. A comparison of the measured laser-induced air-shock velocities for TNT, RDX, DNTF, and LLM-172 doped with Al or B to the detonation velocities predicted by the thermochemical code CHEETAH for inert or active metal participation demonstrates that LASEM has potential for predicting the early time (<10  μs) participation of metal additives in detonation events. The LASEM results show that while Al is mostly inert at early times in the detonation event (confirmed from large-scale detonation testing), B is active-and reducing the amount of hydrogen present during the early chemical reactions increases the resulting estimated detonation velocities.

  5. Theoretical investigation on the heats of formation and detonation performance in polydinitroaminocubanes.

    Science.gov (United States)

    Chi, Weijie; Wang, Xiuyan; Li, Butong; Wu, Haishun

    2012-09-01

    A series of polydinitroaminocubanes have been designed computationally. We calculated the heats of formation, the detonation velocity (D) and detonation pressure (P) of the title compounds by density function theory (DFT) with 6-311 G** basis set. The relationship between the heats of formation and the molecular structures is discussed. The result shows that all cubane derivatives have high and positive heats of formation, which increase with increasing number of dinitroamino groups. The detonation performances of the title compound were estimated by Kamlet-Jacobs equation, and the result indicated that most cubane derivatives have good detonation performance over RDX (hexahydro-1,3,5-trinitro-1,3,5-trizine) and HMX (1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane). In addition, we also found that the heat of detonation (Q) is another very important impact in increasing detonation performance except density. The relative stabilities of the title compound are discussed in the terms of the calculated heats of formation, and the energy gaps between the frontier orbitals. The results have not only shown that these compounds may be used as high energy density compounds (HEDCs), but also provide some useful information for further investigation.

  6. Experimentation and direct numerical simulation of self-similar convergent detonation wave

    Directory of Open Access Journals (Sweden)

    Bozier O.

    2011-01-01

    Full Text Available The propagation of self similar convergent detonation wave in TATB-based explosive composition was studied both experimentally and numerically. The device constists in a 50 mm cylinder of TATB surrounded by an HMX tube. The detonation in HMX overdrives the detonation in TATB which adapts to the propagation velocity with a convergent front at centerline. We measured a curvature of κ = −21.2 m−1 for propagation velocity of 8750 m/s, which extends the knowledge of the (Dn,κ law. A wide ranged EOS/reaction rate model inspired from previous work of Wescott et al. was calibrated to reproduce both the run-to-detonation distance and the newly extended (Dn,κ law for the 1D sligthly curved detonation theory. 2D Direct Numerical Simulations (DNS were made on fine resolved mesh grid for the experimental configuration and for various driver velocities. The simulation reproduces the experimental data both qualitatively (overall detonation structure and quantitatively (κ = −25.4 m−1.

  7. Analysis of the complete detonation state of solutions of TNT in advanced oxidizers

    Energy Technology Data Exchange (ETDEWEB)

    Austing, J.L.; Tulis, A.J. [IIT Research Institute, Chicago, Illinois (United States); Patel, D.L.; Heberlein, D.C. [U.S. Army, Cecom, RD et E Center, NVESD, Virginia (United States)

    1996-12-31

    Solutions of TNT in liquid oxidizers such as dinitrogen tetroxide and chlorine trifluoride are different in chemical composition from that of TNT alone, which is an organic high explosive. The experimentally-measured detonation state of such solutions was mathematically analyzed in accordance with published correlations for conventional explosives. The computations verified that the Chapman-Jouguet density and adiabatic exponent were independent of the chemical composition and were functions only of the initial density. The detonation velocity of a TNT/Dinitrogen Tetroxide change was calculated from the Hugoniot data for the constituent elements by recourse to the method developed by Walker. The calculated velocity was 6.637 km/s, which differed from the experimental value by only 1.6 percent. Detonations of 50/50 by weight TNT/Chlorine Trifluoride solutions confined in glass tubes were conducted at diameters of 131 mm, 77 mm, and 43 mm, for purposes of assessing the diameter effect. The analysis was conducted according to the correlations of Eyring et al. Extrapolation of the detonation velocity-reciprocal diameter curve to infinite diameter established that the ideal detonation velocity was 7.732 km/s. The detonation at the three finite diameters propagated at the near-ideal velocity. The critical diameter was less than 43 mm. (authors) 11 refs.

  8. Shock wave science and technology reference library. Vol. 4. Heterogeneous detonation

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Fan (ed.) [Defence Research and Development Canada, Suffield, AB (Canada)

    2009-07-01

    This book, as a volume of the Shock Wave Science and Technology Reference Library, is primarily concerned with detonation waves or compression shock waves in reactive heterogeneous media, including mixtures of solid, liquid and gas phases. The topics involve a variety of energy release and control processes in such media - a contemporary research field that has found wide applications in propulsion and power, hazard prevention as well as military engineering. The six extensive chapters contained in this volume are: - Spray Detonation (SB Murray and PA Thibault) - Detonation of Gas-Particle Flow (F Zhang) - Slurry Detonation (DL Frost and F Zhang) - Detonation of Metalized Composite Explosives (MF Gogulya and MA Brazhnikov) - Shock-Induced Solid-Solid Reactions and Detonations (YA Gordopolov, SS Batsanov, and VS Trofimov) - Shock Ignition of Particles (SM Frolov and AV Fedorov). Each chapter is self-contained and can be read independently of the others, though, they are thematically interrelated. They offer a timely reference, for graduate students as well as professional scientists and engineers, by laying out the foundations and discussing the latest developments including yet unresolved challenging problems. (orig.)

  9. The DNA damage checkpoint response to replication stress: A Game of Forks.

    Directory of Open Access Journals (Sweden)

    Rachel eJossen

    2013-03-01

    Full Text Available Conditions challenging replication fork progression, collectively referred to as replication stress, represent a major source of genomic instability and are associated to cancer onset. The replication checkpoint, a specialized branch of the DNA damage checkpoint, monitors fork problems and triggers a cellular response aimed at preserving genome integrity. Here, we review the mechanisms by which the replication checkpoint monitors and responds to replication stress, focusing on the checkpoint-mediated pathways contributing to protect replication fork integrity. We discuss how cells achieve checkpoint signaling inactivation once replication stress is overcome and how a failure to timely revert checkpoint-mediated changes in cellular physiology might impact on replication dynamics and genome integrity. We also highlight the checkpoint function as an anti-cancer barrier preventing cells malignant transformation following oncogene-induced replication stress.

  10. NACSA Charter School Replication Guide: The Spectrum of Replication Options. Authorizing Matters. Replication Brief 1

    Science.gov (United States)

    O'Neill, Paul

    2010-01-01

    One of the most important and high-profile issues in public education reform today is the replication of successful public charter school programs. With more than 5,000 failing public schools in the United States, there is a tremendous need for strong alternatives for parents and students. Replicating successful charter school models is an…

  11. Structures in Detonation Waves in Low-Pressure H2–O2–Ar Mixtures: A Summary of Results Obtained with the Adaptive Mesh Refinement Framework AMROC

    Directory of Open Access Journals (Sweden)

    Ralf Deiterding

    2011-01-01

    Full Text Available Numerical simulation can be key to the understanding of the multidimensional nature of transient detonation waves. However, the accurate approximation of realistic detonations is demanding as a wide range of scales needs to be resolved. This paper describes a successful solution strategy that utilizes logically rectangular dynamically adaptive meshes. The hydrodynamic transport scheme and the treatment of the nonequilibrium reaction terms are sketched. A ghost fluid approach is integrated into the method to allow for embedded geometrically complex boundaries. Large-scale parallel simulations of unstable detonation structures of Chapman-Jouguet detonations in low-pressure hydrogen-oxygen-argon mixtures demonstrate the efficiency of the described techniques in practice. In particular, computations of regular cellular structures in two and three space dimensions and their development under transient conditions, that is, under diffraction and for propagation through bends are presented. Some of the observed patterns are classified by shock polar analysis, and a diagram of the transition boundaries between possible Mach reflection structures is constructed.

  12. Prediction of the Chapman–Jouguet chemical equilibrium state in a detonation wave from first principles based reactive molecular dynamics

    OpenAIRE

    Guo, Dezhou; Zybin, Sergey V.; An, Qi; Goddard, William A.; Huang, Fenglei

    2016-01-01

    The combustion or detonation of reacting materials at high temperature and pressure can be characterized by the Chapman–Jouguet (CJ) state that describes the chemical equilibrium of the products at the end of the reaction zone of the detonation wave for sustained detonation. This provides the critical properties and product kinetics for input to macroscale continuum simulations of energetic materials. We propose the ReaxFF Reactive Dynamics to CJ point protocol (Rx2CJ) for predicting the CJ s...

  13. The effect of detonation wave incidence angle on the acceleration of flyers by explosives heavily laden with inert additives

    Science.gov (United States)

    Loiseau, Jason; Georges, William; Frost, David L.; Higgins, Andrew J.

    2017-01-01

    The incidence angle of a detonation wave in a conventional high explosive influences the acceleration and terminal velocity of a metal flyer by increasing the magnitude of the material velocity imparted by the transmitted shock wave as the detonation is tilted towards normal loading. For non-ideal explosives heavily loaded with inert additives, the detonation velocity is typically subsonic relative to the flyer sound speed, leading to shockless accelerations when the detonation is grazing. Further, in a grazing detonation the particles are initially accelerated in the direction of the detonation and only gain velocity normal to the initial orientation of the flyer at later times due to aerodynamic drag as the detonation products expand. If the detonation wave in a non-ideal explosive instead strikes the flyer at normal incidence, a shock is transmitted into the flyer and the first interaction between the particle additives and the flyer occurs due to the imparted material velocity from the passage of the detonation wave. Consequently, the effect of incidence angle and additive properties may play a more prominent role in the flyer acceleration. In the present study we experimentally compared normal detonation loadings to grazing loadings using a 3-mm-thick aluminum slapper to impact-initiate a planar detonation wave in non-ideal explosive-particle admixtures, which subsequently accelerated a second 6.4-mm-thick flyer. Flyer acceleration was measured with heterodyne laser velocimetry (PDV). The explosive mixtures considered were packed beds of glass or steel particles of varying sizes saturated with sensitized nitromethane, and gelled nitromethane mixed with glass microballoons. Results showed that the primary parameter controlling changes in flyer velocity was the presence of a transmitted shock, with additive density and particle size playing only secondary roles. These results are similar to the grazing detonation experiments, however under normal loading the

  14. International Expansion through Flexible Replication

    DEFF Research Database (Denmark)

    Jonsson, Anna; Foss, Nicolai Juul

    2011-01-01

    to local environments and under the impact of new learning. To illuminate these issues, we draw on a longitudinal in-depth study of Swedish home furnishing giant IKEA, involving more than 70 interviews. We find that IKEA has developed organizational mechanisms that support an ongoing learning process aimed......, etc.) are replicated in a uniform manner across stores, and change only very slowly (if at all) in response to learning (“flexible replication”). We conclude by discussing the factors that influence the approach to replication adopted by an international replicator....

  15. The Psychology of Replication and Replication in Psychology.

    Science.gov (United States)

    Francis, Gregory

    2012-11-01

    Like other scientists, psychologists believe experimental replication to be the final arbiter for determining the validity of an empirical finding. Reports in psychology journals often attempt to prove the validity of a hypothesis or theory with multiple experiments that replicate a finding. Unfortunately, these efforts are sometimes misguided because in a field like experimental psychology, ever more successful replication does not necessarily ensure the validity of an empirical finding. When psychological experiments are analyzed with statistics, the rules of probability dictate that random samples should sometimes be selected that do not reject the null hypothesis, even if an effect is real. As a result, it is possible for a set of experiments to have too many successful replications. When there are too many successful replications for a given set of experiments, a skeptical scientist should be suspicious that null or negative findings have been suppressed, the experiments were run improperly, or the experiments were analyzed improperly. This article describes the implications of this observation and demonstrates how to test for too much successful replication by using a set of experiments from a recent research paper.

  16. Regulation of Replication Recovery and Genome Integrity

    DEFF Research Database (Denmark)

    Colding, Camilla Skettrup

    Preserving genome integrity is essential for cell survival. To this end, mechanisms that supervise DNA replication and respond to replication perturbations have evolved. One such mechanism is the replication checkpoint, which responds to DNA replication stress and acts to ensure replication pausing...

  17. Counting vacancies and nitrogen-vacancy centers in detonation nanodiamond

    Science.gov (United States)

    Chang, Shery L. Y.; Barnard, Amanda S.; Dwyer, Christian; Boothroyd, Chris B.; Hocking, Rosalie K.; Ōsawa, Eiji; Nicholls, Rebecca J.

    2016-05-01

    Detonation nanodiamond particles (DND) contain highly-stable nitrogen-vacancy (N-V) centers, making it important for quantum-optical and biotechnology applications. However, due to the small particle size, the N-V concentrations are believed to be intrinsically very low, spawning efforts to understand the formation of N-V centers and vacancies, and increase their concentration. Here we show that vacancies in DND can be detected and quantified using simulation-aided electron energy loss spectroscopy. Despite the small particle size, we find that vacancies exist at concentrations of about 1 at%. Based on this experimental finding, we use ab initio calculations to predict that about one fifth of vacancies in DND form N-V centers. The ability to directly detect and quantify vacancies in DND, and predict the corresponding N-V formation probability, has a significant impact to those emerging technologies where higher concentrations and better dispersion of N-V centres are critically required.Detonation nanodiamond particles (DND) contain highly-stable nitrogen-vacancy (N-V) centers, making it important for quantum-optical and biotechnology applications. However, due to the small particle size, the N-V concentrations are believed to be intrinsically very low, spawning efforts to understand the formation of N-V centers and vacancies, and increase their concentration. Here we show that vacancies in DND can be detected and quantified using simulation-aided electron energy loss spectroscopy. Despite the small particle size, we find that vacancies exist at concentrations of about 1 at%. Based on this experimental finding, we use ab initio calculations to predict that about one fifth of vacancies in DND form N-V centers. The ability to directly detect and quantify vacancies in DND, and predict the corresponding N-V formation probability, has a significant impact to those emerging technologies where higher concentrations and better dispersion of N-V centres are critically

  18. The Effect of the Pre-Detonation Stellar Internal Velocity Profile on the Nucleosynthetic Yields in Type Ia Supernova

    CERN Document Server

    Kim, Yeunjin; Graziani, Carlo; Meyer, B S; Lamb, D Q; Truran, J W

    2013-01-01

    A common model of the explosion mechanism of Type Ia supernovae is based on a delayed detonation of a white dwarf. A variety of models differ primarily in the method by which the deflagration leads to a detonation. A common feature of the models, however, is that all of them involve the propagation of the detonation through a white dwarf that is either expanding or contracting, where the stellar internal velocity profile depends on both time and space. In this work, we investigate the effects of the pre-detonation stellar internal velocity profile and the post-detonation velocity of expansion on the production of alpha-particle nuclei, including Ni56, which are the primary nuclei produced by the detonation wave. We perform one-dimensional hydrodynamic simulations of the explosion phase of the white dwarf for center and off-center detonations with five different stellar velocity profiles at the onset of the detonation. We observe two distinct post-detonation expansion phases: rarefaction and bulk expansion. Al...

  19. DNA replication stress restricts ribosomal DNA copy number.

    Science.gov (United States)

    Salim, Devika; Bradford, William D; Freeland, Amy; Cady, Gillian; Wang, Jianmin; Pruitt, Steven C; Gerton, Jennifer L

    2017-09-15

    Ribosomal RNAs (rRNAs) in budding yeast are encoded by ~100-200 repeats of a 9.1kb sequence arranged in tandem on chromosome XII, the ribosomal DNA (rDNA) locus. Copy number of rDNA repeat units in eukaryotic cells is maintained far in excess of the requirement for ribosome biogenesis. Despite the importance of the repeats for both ribosomal and non-ribosomal functions, it is currently not known how "normal" copy number is determined or maintained. To identify essential genes involved in the maintenance of rDNA copy number, we developed a droplet digital PCR based assay to measure rDNA copy number in yeast and used it to screen the yeast conditional temperature-sensitive mutant collection of essential genes. Our screen revealed that low rDNA copy number is associated with compromised DNA replication. Further, subculturing yeast under two separate conditions of DNA replication stress selected for a contraction of the rDNA array independent of the replication fork blocking protein, Fob1. Interestingly, cells with a contracted array grew better than their counterparts with normal copy number under conditions of DNA replication stress. Our data indicate that DNA replication stresses select for a smaller rDNA array. We speculate that this liberates scarce replication factors for use by the rest of the genome, which in turn helps cells complete DNA replication and continue to propagate. Interestingly, tumors from mini chromosome maintenance 2 (MCM2)-deficient mice also show a loss of rDNA repeats. Our data suggest that a reduction in rDNA copy number may indicate a history of DNA replication stress, and that rDNA array size could serve as a diagnostic marker for replication stress. Taken together, these data begin to suggest the selective pressures that combine to yield a "normal" rDNA copy number.

  20. Competition and cooperation in dynamic replication networks.

    Science.gov (United States)

    Dadon, Zehavit; Wagner, Nathaniel; Alasibi, Samaa; Samiappan, Manickasundaram; Mukherjee, Rakesh; Ashkenasy, Gonen

    2015-01-07

    The simultaneous replication of six coiled-coil peptide mutants by reversible thiol-thioester exchange reactions is described. Experimental analysis of the time dependent evolution of networks formed by the peptides under different conditions reveals a complex web of molecular interactions and consequent mutant replication, governed by competition for resources and by autocatalytic and/or cross-catalytic template-assisted reactions. A kinetic model, first of its kind, is then introduced, allowing simulation of varied network behaviour as a consequence of changing competition and cooperation scenarios. We suggest that by clarifying the kinetic description of these relatively complex dynamic networks, both at early stages of the reaction far from equilibrium and at later stages approaching equilibrium, one lays the foundation for studying dynamic networks out-of-equilibrium in the near future.

  1. Deposition and Characterization of the Titanium-Based Coating by a Multi-Chamber Detonation Sprayer

    Directory of Open Access Journals (Sweden)

    Arseenko M.Yu.

    2015-01-01

    Full Text Available This work introduces some of the aspects of the deposition of titanium-based coating (80-120 μm thick on aluminium samples using a multi-chamber detonation sprayer (MCDS. The characteristic feature of MCDS is that the powder is accelerated by using combustion products that are formed in MCDS chambers and are converged before entering the nozzle, where they interact with the two-phase gas-powder cloud. The microstructures and properties of the coating were characterized with the use of scanning electronic microscopes (SEM, optical microscope (OM, X-ray Diffraction (XRD techniques, and Vickers hardness tester with a 50 g test load. Wear tests were carried out using a computer controlled pin-on-disc type tribometer. It was established that MCDS has provided the conditions for formation of a dense titanium-based coating with a porosity of less than 1.0%, microhardness 810±250 HV0.05 and a specific wear rate of 2.077∙10-4 mm3(m∙N-1.

  2. Helium accreting CO white dwarfs with rotation: helium novae instead of double detonation

    CERN Document Server

    Yoon, S C

    2004-01-01

    We present evolutionary models of helium accreting carbon-oxygen white dwarfs in which we include the effects of the spin-up of the accreting star induced by angular momentum accretion, rotationally induced chemical mixing and rotational energy dissipation. Initial masses of 0.6 Msun and 0.8 Msun and constant accretion rates of a few times 10^{-8} Msun/yr of helium rich matter have been considered, which is typical for the sub-Chandrasekhar mass progenitor scenario for Type Ia supernovae. It is found that the helium envelope in an accreting white dwarf is heated efficiently by friction in the differentially rotating spun-up layers. As a result, helium ignites much earlier and under much less degenerate conditions compared to the corresponding non-rotating case. Consequently, a helium detonation may be avoided, which questions the sub-Chandrasekhar mass progenitor scenario for Type Ia supernovae. We discuss implications of our results for the evolution of helium star plus white dwarf binary systems as possible...

  3. Evaluating Systematic Dependencies of Type Ia Supernovae: The Influence of Deflagration to Detonation Density

    CERN Document Server

    Jackson, Aaron P; Townsley, Dean M; Chamulak, David A; Brown, Edward F; Timmes, F X

    2010-01-01

    We explore the effects of the deflagration to detonation transition (DDT) density on the production of Ni-56 in thermonuclear supernova explosions (type Ia supernovae). Within the DDT paradigm, the transition density sets the amount of expansion during the deflagration phase of the explosion and therefore the amount of nuclear statistical equilibrium (NSE) material produced. We employ a theoretical framework for a well-controlled statistical study of two-dimensional simulations of thermonuclear supernovae with randomized initial conditions that can, with a particular choice of transition density, produce a similar average and range of Ni-56 masses to those inferred from observations. Within this framework, we utilize a more realistic "simmered" white dwarf progenitor model with a flame model and energetics scheme to calculate the amount of Ni-56 and NSE material synthesized for a suite of simulated explosions in which the transition density is varied in the range 1-3x10^7 g/cc. We find a quadratic dependence ...

  4. The effect of turbulent intermittency on the deflagration to detonation transition in SN Ia explosions

    CERN Document Server

    Pan, Liubin; Scalo, John

    2008-01-01

    We examine the effects of turbulent intermittency on the deflagration to detonation transition (DDT) in Type Ia supernovae. The Zel'dovich mechanism for DDT requires the formation of a nearly isothermal region of mixed ash and fuel that is larger than a critical size. We primarily consider the hypothesis by Khokhlov et al. and Niemeyer and Woosley that the nearly isothermal, mixed region is produced when the flame makes the transition to the distributed regime. We use two models for the distribution of the turbulent velocity fluctuations to estimate the probability as a function of the density in the exploding white dwarf that a given region of critical size is in the distributed regime due to strong local turbulent stretching of the flame structure. We also estimate lower limits on the number of such regions as a function of density. We find that the distributed regime, and hence perhaps DDT, occurs in a local region of critical size at a density at least a factor of 2-3 larger than predicted for mean condit...

  5. Physical and technological factors of the formation of detonation capacity of blasthole charges of emulsion explosives

    Directory of Open Access Journals (Sweden)

    Poplavsky V.A.

    2017-04-01

    Full Text Available Modern conditions of mining are characterized by a constant increase in the depth of the pit, as a result of this there is a change in the geological and mining conditions. The obtaining of the mined rock is provided by using the drilling-and-blasting method as the main process that influences the technical and economic indicators of the next processes and enterprises in general. The effectiveness of the explosion in rocks depends on the technology of blasting. In scientific and technical literature the influence of various natural and technological factors on the process of the explosion has been studied in detail. We developed methods and recommendations for calculating the parameters of mass blasting used in common projects in the blasting operation and ensure their implementation of getting the rock mass of different coarseness of grading. However, these methods are based on traditional formulas and empirical dependencies, according to which the parameters of location and charge blasting accepted as the same, despite the fact that the blocks that blasted may include different types of rocks, and this, in turn, causes predatory yield of sub-standard fractions. Therefore, the implementation of the design parameters of the blasting should be based on modern scientific achievements, interrelationships of geological and technological indicators and parameters with the least expenditure of labor and time in the design process. The article analyzes the impact of the physical condition and the composition of emulsion explosive, geometric parameters and conditions of charge blasting, characteristics of dynamic processes in the charge and the decomposed array for the manifestation of the phenomenon of desensibilization emulsion explosives. Keywords: desensibilization; detonation speed; critical diameter; ; hydrostatic pressure; gas-generating process; shock wave; boulder.

  6. Biomarkers of replicative senescence revisited

    DEFF Research Database (Denmark)

    Nehlin, Jan

    2016-01-01

    Biomarkers of replicative senescence can be defined as those ultrastructural and physiological variations as well as molecules whose changes in expression, activity or function correlate with aging, as a result of the gradual exhaustion of replicative potential and a state of permanent cell cycle...... with their chronological age and present health status, help define their current rate of aging and contribute to establish personalized therapy plans to reduce, counteract or even avoid the appearance of aging biomarkers....

  7. Characterizing the energy output generated by a standard electric detonator using shadowgraph imaging

    Science.gov (United States)

    Petr, V.; Lozano, E.

    2017-09-01

    This paper overviews a complete method for the characterization of the explosive energy output from a standard detonator. Measurements of the output of explosives are commonly based upon the detonation parameters of the chemical energy content of the explosive. These quantities provide a correct understanding of the energy stored in an explosive, but they do not provide a direct measure of the different modes in which the energy is released. This optically based technique combines high-speed and ultra-high-speed imaging to characterize the casing fragmentation and the detonator-driven shock load. The procedure presented here could be used as an alternative to current indirect methods—such as the Trauzl lead block test—because of its simplicity, high data accuracy, and minimum demand for test repetition. This technique was applied to experimentally measure air shock expansion versus time and calculating the blast wave energy from the detonation of the high explosive charge inside the detonator. Direct measurements of the shock front geometry provide insight into the physics of the initiation buildup. Because of their geometry, standard detonators show an initial ellipsoidal shock expansion that degenerates into a final spherical wave. This non-uniform shape creates variable blast parameters along the primary blast wave. Additionally, optical measurements are validated using piezoelectric pressure transducers. The energy fraction spent in the acceleration of the metal shell is experimentally measured and correlated with the Gurney model, as well as to several empirical formulations for blasts from fragmenting munitions. The fragment area distribution is also studied using digital particle imaging analysis and correlated with the Mott distribution. Understanding the fragmentation distribution plays a critical role when performing hazard evaluation from these types of devices. In general, this technique allows for characterization of the detonator within 6-8% error

  8. Initiation of detonation by impact on granular explosives; Contribution a l'etude de la generation de la detonation provoquee par impact sur un explosif

    Energy Technology Data Exchange (ETDEWEB)

    Bernier, H. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-05-15

    A good number of experiments have shown up the particular behaviour of granular explosives when they are detonated by barrier transmitted shocks. Similar results can be obtained when the shock is induced by impact. In this case the pressure signal shape applied at the explosive is better known and both its intensity and duration can be varied. By using a mathematical model in which the law of chemical kinetics is a linear function of pressure, and different temperatures are used for solids and gases, it is possible to describe most of the behaviour of detonation initiation in solid granular explosives. (author) [French] De nombreuses etudes experimentales ont montre le comportement particulier des explosifs granulaires lors de la detonation provoquee par choc transmis a travers une barriere. Les memes resultats peuvent etre obtenus lorsque la detonation est engendree par impact. Dans ce cas, la forme du signal de pression induit dans l'explosif est mieux connue, et il est possible d'en faire varier l'intensite et la duree d'application. Un modele mathematique utilisant une loi de cinetique chimique fonction lineaire de la pression et ou les temperatures des etats solide et gazeux pendant la reaction sont differenciees, permet de retrouver la plupart des caracteres specifiques de la generation dans un explosif solide granulaire. (auteur)

  9. Nucleotide Metabolism and DNA Replication.

    Science.gov (United States)

    Warner, Digby F; Evans, Joanna C; Mizrahi, Valerie

    2014-10-01

    The development and application of a highly versatile suite of tools for mycobacterial genetics, coupled with widespread use of "omics" approaches to elucidate the structure, function, and regulation of mycobacterial proteins, has led to spectacular advances in our understanding of the metabolism and physiology of mycobacteria. In this article, we provide an update on nucleotide metabolism and DNA replication in mycobacteria, highlighting key findings from the past 10 to 15 years. In the first section, we focus on nucleotide metabolism, ranging from the biosynthesis, salvage, and interconversion of purine and pyrimidine ribonucleotides to the formation of deoxyribonucleotides. The second part of the article is devoted to DNA replication, with a focus on replication initiation and elongation, as well as DNA unwinding. We provide an overview of replication fidelity and mutation rates in mycobacteria and summarize evidence suggesting that DNA replication occurs during states of low metabolic activity, and conclude by suggesting directions for future research to address key outstanding questions. Although this article focuses primarily on observations from Mycobacterium tuberculosis, it is interspersed, where appropriate, with insights from, and comparisons with, other mycobacterial species as well as better characterized bacterial models such as Escherichia coli. Finally, a common theme underlying almost all studies of mycobacterial metabolism is the potential to identify and validate functions or pathways that can be exploited for tuberculosis drug discovery. In this context, we have specifically highlighted those processes in mycobacterial DNA replication that might satisfy this critical requirement.

  10. Plasmid Rolling-Circle Replication.

    Science.gov (United States)

    Ruiz-Masó, J A; MachóN, C; Bordanaba-Ruiseco, L; Espinosa, M; Coll, M; Del Solar, G

    2015-02-01

    Plasmids are DNA entities that undergo controlled replication independent of the chromosomal DNA, a crucial step that guarantees the prevalence of the plasmid in its host. DNA replication has to cope with the incapacity of the DNA polymerases to start de novo DNA synthesis, and different replication mechanisms offer diverse solutions to this problem. Rolling-circle replication (RCR) is a mechanism adopted by certain plasmids, among other genetic elements, that represents one of the simplest initiation strategies, that is, the nicking by a replication initiator protein on one parental strand to generate the primer for leading-strand initiation and a single priming site for lagging-strand synthesis. All RCR plasmid genomes consist of a number of basic elements: leading strand initiation and control, lagging strand origin, phenotypic determinants, and mobilization, generally in that order of frequency. RCR has been mainly characterized in Gram-positive bacterial plasmids, although it has also been described in Gram-negative bacterial or archaeal plasmids. Here we aim to provide an overview of the RCR plasmids' lifestyle, with emphasis on their characteristic traits, promiscuity, stability, utility as vectors, etc. While RCR is one of the best-characterized plasmid replication mechanisms, there are still many questions left unanswered, which will be pointed out along the way in this review.

  11. Numerical Research on Detonation Wave Characteristic in High Temperature Supersonic Flow%高温超声速流中爆震波特性数值研究

    Institute of Scientific and Technical Information of China (English)

    黄思源; 桂业伟; 白菡尘

    2012-01-01

    通过对高温超声速流中爆震波性质的研究,评估其在高超声速冲压发动机燃烧室的燃烧组织中应用的可行性,并通过数值模拟对分析结论进行了验证。提出了一种新的爆震波起爆机制,注入高温超声速流中的燃料混气可通过自身缓慢的释热使流动进入局域热壅塞状态,进而借助局域热壅塞产生的激波实现爆震波的起爆。计算结果表明在适宜的温度与马赫数条件下,注入高温超声速流中的燃料可通过新的起爆机制在超声速流中形成一道稳定的驻定爆震波。表明在高超声速冲压发动机燃烧室中存在着通过驻定爆震波实现火焰稳定的可能性。%To evaluate the feasibility for utilizing the detonation wave to stabilize flame in scramjet combustor,the detona- tion wave characteristic in high temperature environment was studied by numerical simulations. A new initiation mechanism of detonation was presented. The premixed gas injected into high temperature supersonic flow can reach local thermal choking state through the heat released by slow reaction of premixed fuel gas and then a detonation wave can be initiated by shock pro- duced in thermal choking state. The numerical results show that the fuel injected into high temperature supersonic flow can form a standing detonation wave by the new mechanism in some special temperature and Mach number flow conditions. The re- search shows that it is possible utilizing the standing detonation wave to stabilize flame in scramjet combustor.

  12. Recent papers from DX-1, detonation science and technology

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    Over the past year members of DX-1 have participated in several conferences where presentations were made and papers prepared for proceedings. There have also been several papers published in or submitted to refereed journals for publication. Rather that attach all these papers to the DX-1 Quarterly Report, we decided to put them in a Los Alamos report that could be distributed to those who get the quarterly, as well as others that have an interest in the work being done in DX-1 both inside and outside the Laboratory. This compilation does not represent all the work reported during the year because some people have chosen not to include their work here. In particular, there were a number of papers relating to deflagration-to-detonation modeling that were not included. However, this group of papers does present a good picture of much of the unclassified work being done in DX-1. Several of the papers include coauthors from other groups or divisions at the Laboratory, providing an indication of the collaborations in which people in DX-1 are involved. Discussed topics of submitted papers include: shock compression of condensed matter, pyrotechnics, shock waves, molecular spectroscopy, sound speed measurements in PBX-9501, chemical dimerization, and micromechanics of spall and damage in tantalum.

  13. Effect of spatial discretization of energy on detonation wave propagation

    CERN Document Server

    Mi, XiaoCheng; Higgins, Andrew J

    2016-01-01

    Detonation propagation in the limit of highly spatially discretized energy sources is investigated. The model of this problem begins with a medium consisting of a calorically perfect gas with a prescribed energy release per unit mass. The energy release is collected into sheet-like sources that are now embedded in an inert gas that fills the spaces between them. The release of energy in the first sheet results in a planar blast wave that propagates to the next source, which is triggered after a prescribed delay, generating a new blast, and so forth. The resulting wave dynamics as the front passes through hundreds of such sources is computationally simulated by numerically solving the governing one-dimensional Euler equations in the lab-fixed reference frame. The average wave speed for each simulation is measured once the wave propagation has reached a quasi-periodic solution. Velocities in excess of the CJ speed are found as the sources are made increasingly discrete, with the deviation above CJ being as grea...

  14. Neutrinos from Type Ia Supernovae: The Gravitationally Confined Detonation Scenario

    CERN Document Server

    Wright, Warren P; Ohlmann, Sebastian T; Roepke, Friedrich K; Scholberg, Kate; Seitenzahl, Ivo R

    2016-01-01

    Despite their use as cosmological distance indicators and their importance in the chemical evolution of Galaxies, the unequivocal identification of the progenitor systems and explosion mechanism of normal Type Ia supernova (SN Ia) remains elusive. The leading hypothesis is that such a supernova is a thermonuclear explosion of a carbon-oxygen white dwarf but the exact explosion mechanism is still a matter of debate. Observation of a Galactic SN Ia would be of immense value in answering the many open questions related to these events. One potentially useful source of information about the explosion mechanism and progenitor is the neutrino signal. In this paper we compute the expected neutrino signal from a Gravitationally Confined Detonation (GCD) explosion scenario for a SN~Ia and show how the flux at Earth contains features in time and energy unique to this scenario. We then calculate the expected event rates in the Super-K, Hyper-K, JUNO, DUNE, and IceCube detectors and find both Hyper-K and IceCube would se...

  15. Three-dimensional CLEM-LES of irregular detonation propagation

    Science.gov (United States)

    Maxwell, Brian; Radulescu, Matei

    2016-11-01

    Recently, thin-channel experiments and 2D simulations have been conducted in order to investigate the effect of turbulent mixing rates on the structure of irregular detonation wave propagation. Furthermore, the dependence of the observed cell pattern, and also the reaction zone thickness, on the mixing of burned products with pockets of unburned gases, was investigated. The current work now includes 3D simulations, which are conducted to provide further validation of, and insight into, the 2D results. All simulations have been conducted using the Compressible Linear Eddy Model for Large Eddy Simulation (CLEM-LES). To date, the 3D results are found to match closely the previous 2D results. The agrreement is partly due to sufficient resolution of the large scale fluid motions, which are observed experimentally to be predominant in only two directions. Furthermore, the CLEM-LES methodology incorporates 3D mixing effects at the subgrid level. Finally, it was found that turbulent fluctuations on the subgrid were found to give rise to statistically lower than average propagation velocities on the wave front. This lead to longer ignition delays for large amounts of gas passing through the wave, giving rise to the unburned pockets of gas observed experimentally. Authors would like to acknowledge NSERC and Shell for project funding.

  16. Bioequivalence of two lansoprazole delayed release capsules 30 mg in healthy male volunteers under fasting, fed and fasting-applesauce conditions: a partial replicate crossover study design to estimate the pharmacokinetics of highly variable drugs.

    Science.gov (United States)

    Thota, S; Khan, S M; Tippabhotla, S K; Battula, R; Gadiko, C; Vobalaboina, V

    2013-11-01

    An open-label, 2-treatment, 3-sequence, 3-period, single-dose, partial replicate crossover studies under fasting (n=48), fed (n=60) and fasting-applesauce (n=48) (sprinkled on one table spoonful of applesauce) modalities were conducted in healthy adult male volunteers to evaluate bioequivalence between 2 formulations of lansoprazole delayed release capsules 30 mg. In all the 3 studies, as per randomization, either test or reference formulations were administered in a crossover manner with a required washout period of at least 7 days. Blood samples were collected adequately (0-24 h) to determine lansoprazole plasma concentrations using a validated LC-MS/MS analytical method. To characterize the pharmacokinetic parameters (Cmax, AUC0-t, AUC0-∞, Tmax, Kel and T1/2) of lansoprazole, non-compartmental analysis and ANOVA was applied on ln-transformed values. The bioequivalence was tested based on within-subject variability of the reference formulation. In fasting and fed studies (within-subject variability>30%) bioequivalence was evaluated with scaled average bioequivalence, hence for the pharmacokinetic parameters Cmax, AUC0-t and AUC0-∞, the 95% upper confidence bound for (μT-μR)2-θσ2 WR was ≤0, and the point estimates (test-to-reference ratio) were within the regulatory acceptance limit 80.00-125.00%. In fasting-applesauce study (within-subject variability<30%) bioequivalence was evaluated with average bioequivalence, the 90% CI of ln-transformed data of Cmax, AUC0-t and AUC0-∞ were within the regulatory acceptance limit 80.00-125.00%. Based on these aforesaid statistical inferences, it was concluded that the test formulation is bioequivalent to reference formulation.

  17. Detonation nanodiamond complexes with cancer stem cells inhibitors or paracrine products of mesenchymal stem cells as new potential medications

    Science.gov (United States)

    Konoplyannikov, A. G.; Alekseenskiy, A. E.; Zlotin, S. G.; Smirnov, B. B.; Kalsina, S. Sh.; Lepehina, L. A.; Semenkova, I. V.; Agaeva, E. V.; Baboyan, S. B.; Rjumshina, E. A.; Nosachenko, V. V.; Konoplyannikov, M. A.

    2015-09-01

    Combined use of complexes of the most active chemotherapeutic drugs and detonation nanodiamonds (DND) is a new trend in cancer therapy, which is probably related to selective chemotherapeutic drug delivery by DND to the zone of so-called cancer stem cells (CSC). Stable DND complexes of 4-5 nm size with salinomycin—a strong CSC inhibitor—have been obtained (as a suspension). It has been demonstrated that a complex administration considerably increases the drug antitumor effect on the transplantable tumor of LLC mice. A similar effect has been observed in CSC models in vivo, obtained by exposure of stem cells of normal mice tissues to a carcinogen 1,2-dimethylhydrazine. It has also been found out, that administration of DND complexes with the conditioned medium from mesenchymal stem cells (MSC) cultures to mice results in a considerable stimulation of stem cell pools in normal mice tissues, which can be used in regenerative medicine.

  18. Replication Regulates Volume Weighting in Quantum Cosmology

    CERN Document Server

    Hartle, James

    2009-01-01

    Probabilities for observations in cosmology are conditioned both on the universe's quantum state and on local data specifying the observational situation. We show the quantum state defines a measure for prediction through such conditional probabilities that is well behaved for spatially large or infinite universes when the probabilities that our data is replicated are taken into account. In histories where our data are rare volume weighting connects top-down probabilities conditioned on both the data and the quantum state to the bottom-up probabilities conditioned on the quantum state alone. We apply these principles to a calculation of the number of inflationary e-folds in a homogeneous, isotropic minisuperspace model with a single scalar field moving in a quadratic potential. We find that volume weighting is justified and the top-down probabilities favor a large number of e-folds.

  19. Pressure and Thrust Measurements of a High-Frequency Pulsed Detonation Tube

    Science.gov (United States)

    Nguyen, N.; Cutler, A. D.

    2008-01-01

    This paper describes measurements of a small-scale, high-frequency pulsed detonation tube. The device utilized a mixture of H2 fuel and air, which was injected into the device at frequencies of up to 1200 Hz. Pulsed detonations were demonstrated in an 8-inch long combustion volume, at about 600 Hz, for the quarter wave mode of resonance. The primary objective of this experiment was to measure the generated thrust. A mean value of thrust was measured up to 6.0 lb, corresponding to H2 flow based specific impulse of 2970 s. This value is comparable to measurements in H2-fueled pulsed detonation engines (PDEs). The injection and detonation frequency for this new experimental case was much higher than typical PDEs, where frequencies are usually less than 100 Hz. The compact size of the device and high frequency of detonation yields a thrust-per-unit-volume of approximately 2.0 pounds per cubic inch, and compares favorably with other experiments, which typically have thrust-per-unit-volume of order 0.01 pound per cubic inch. This much higher volumetric efficiency results in a potentially much more practical device than the typical PDE, for a wide range of potential applications, including high-speed boundary layer separation control, for example in hypersonic engine inlets, and propulsion for small aircraft and missiles.

  20. Pressure and Thrust Measurements of a High-Frequency Pulsed-Detonation Actuator

    Science.gov (United States)

    Nguyen, Namtran C.; Cutler, Andrew D.

    2008-01-01

    This paper describes the development of a small-scale, high-frequency pulsed detonation actuator. The device utilized a fuel mixture of H2 and air, which was injected into the device at frequencies of up to 1200 Hz. Pulsed detonations were demonstrated in an 8-inch long combustion volume, at approx.600 Hz, for the lambda/4 mode. The primary objective of this experiment was to measure the generated thrust. A mean value of thrust was measured up to 6.0 lb, corresponding to specific impulse of 2611 s. This value is comparable to other H2-fueled pulsed detonation engines (PDEs) experiments. The injection and detonation frequency for this new experimental case was approx.600 Hz, and was much higher than typical PDEs, where frequencies are usually less than 100 Hz. The compact size of the model and high frequency of detonation yields a thrust-per-unit-volume of approximately 2.0 lb/cu in, and compares favorably with other experiments, which typically have thrust-per-unit-volume values of approximately 0.01 lb/cu in.