Glucometabolic effects of single and repeated exposure to forced-swimming stressor in Sprague-Dawley rats.

Science.gov (United States)

Morakinyo, Ayodele Olufemi; Iranloye, Bolanle Olubusola; Ogunsola, Oluseyi Abimbola

2018-04-01

We aimed to evaluate the effects of a single (acute) and repeated (chronic) exposure to forced-swimming stressor on glucose tolerance, insulin sensitivity, lipid profile and glycogen content in male rats. Thirty adult male Sprague-Dawley rats (12 weeks old) were divided randomly into five groups: control group, single exposure (SE) to forced-swim stressor, repeated exposure to forced-swim stressor for 7 days (RE7), 14 days (RE14) and 28 days (RE28). Glucose tolerance test and Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) were undertaken on fasting rats to obtain glucose and insulin profiles. ELISA was performed to assess plasma insulin and corticosterone levels. Total cholesterol, triglyceride, high- and low-density lipoproteins, hepatic and skeletal glycogen content were also determined. Repeated exposure to stressor induced glucose intolerance and insulin resistance in the experimental rats. Results showed that all RE groups exhibited a significantly higher area under the curve compared with others (p=0.0001); similarly, HOMA-IR increased (p=0.0001) in all RE groups compared with control. Prolonged exposure to stressor significantly increased the plasma insulin and corticosterone levels but decreased the glycogen content in the liver and skeletal muscle when compared with the control group. Additionally, chronic stressor significantly increased the total cholesterol and triglyceride levels, however, acute stressor produced significantly elevated high-density lipoproteins level. In conclusion, repeated exposure to forced-swimming stressor induced glucose intolerance and insulin resistance in rats by disrupting the insulin sensitivity as well as heightening the glycogenolysis in the liver and skeletal muscle. Acute stressor was unable to cause glucose intolerance and insulin resistance but it appears that may have a positive effect on the lipid metabolism.

Hooke: an open software platform for force spectroscopy.

Science.gov (United States)

Sandal, Massimo; Benedetti, Fabrizio; Brucale, Marco; Gomez-Casado, Alberto; Samorì, Bruno

2009-06-01

Hooke is an open source, extensible software intended for analysis of atomic force microscope (AFM)-based single molecule force spectroscopy (SMFS) data. We propose it as a platform on which published and new algorithms for SMFS analysis can be integrated in a standard, open fashion, as a general solution to the current lack of a standard software for SMFS data analysis. Specific features and support for file formats are coded as independent plugins. Any user can code new plugins, extending the software capabilities. Basic automated dataset filtering and semi-automatic analysis facilities are included. Software and documentation are available at (http://code.google.com/p/hooke). Hooke is a free software under the GNU Lesser General Public License.

Atomic force microscopy-based repeated machining theory for nanochannels on silicon oxide surfaces

Energy Technology Data Exchange (ETDEWEB)

Wang, Z.Q., E-mail: wangzhiqian@sia.cn [State Key Laboratory of Robotics, Shenyang Institute of Automation, CAS, Shenyang 110016 (China); Graduate University of the Chinese Academy of Sciences, Beijing 100049 (China); Jiao, N.D. [State Key Laboratory of Robotics, Shenyang Institute of Automation, CAS, Shenyang 110016 (China); Tung, S. [Department of Mechanical Engineering, University of Arkansas, Fayetteville, AR 72701 (United States); Dong, Z.L. [State Key Laboratory of Robotics, Shenyang Institute of Automation, CAS, Shenyang 110016 (China)

2011-02-01

The atomic force microscopy (AFM)-based repeated nanomachining of nanochannels on silicon oxide surfaces is investigated both theoretically and experimentally. The relationships of the initial nanochannel depth vs. final nanochannel depth at a normal force are systematically studied. Using the derived theory and simulation results, the final nanochannel depth can be predicted easily. Meanwhile, if a nanochannel with an expected depth needs to be machined, a right normal force can be selected simply and easily in order to decrease the wear of the AFM tip. The theoretical analysis and simulation results can be effectively used for AFM-based fabrication of nanochannels.

Attractive and repulsive quantum forces from dimensionality of space

DEFF Research Database (Denmark)

Bialynicki-Birula, I.; Cirone, M.A.; Dahl, Jens Peder

2002-01-01

Two particles of identical mass attract and repel each other even when there exist no classical external forces and their average relative momentum vanishes. This quantum force depends crucially on the number of dimensions of space.......Two particles of identical mass attract and repel each other even when there exist no classical external forces and their average relative momentum vanishes. This quantum force depends crucially on the number of dimensions of space....

Landscape Management of Public Open Space in Bogor Heritage City

Science.gov (United States)

Pusparini, F. D.; Nurhayati; Arifin, H. S.

2017-10-01

Public open space landscape plays important role in Bogor Heritage City. Although these spaces can carry various kind of public activities and enhance environment quality, they are fragile to disturbance and changing due to city development. Therefore, as an effort to maintain public open space landscape in 8 zones within Heritage City of Bogor, management of public open space landscape is necessary. Syntesys of public open space landscape management had held by using Analytical Hierarchy Process (AHP). The AHP result showed public open space landscape in Palace and Botanical Garden of Bogor zone (20%) is in high priority to be maintained. The other zone are Situ Gede (16,9%), Plan Karsten (12,3%), European Settlement (12%), Suryakencana (11,2%), Batu Tulis (10,2%), Empang (9.2%) and West Development (8,2%). Ecological function (34,8%) becomes the most important function to be maintained (34.8%) then social culture (31.2%), economic (17%), and aesthetics (17%).

Quality of Public Open Spaces and Recreational Walking.

Science.gov (United States)

Sugiyama, Takemi; Gunn, Lucy D; Christian, Hayley; Francis, Jacinta; Foster, Sarah; Hooper, Paula; Owen, Neville; Giles-Corti, Billie

2015-12-01

We examined associations between specific public open space (POS) attributes and recreational walking to local POS. Between October 2004 and December 2006, 1465 adults of the RESIDential Environments Project, conducted in Perth, Australia, reported whether they walk to a POS for recreation. For each participant, we identified all open spaces larger than 0.8 hectares within 1.6 kilometers from home. On the basis of field audit data, we created 3 scores (presence, count, size-weighted presence) for 19 specific open space attributes. With logistic regression analyses, we found that walking to a POS was associated with the presence of gardens, grassed areas, walking paths, water features, wildlife, amenities, dog-related facilities, and off-leash areas for dogs. It was also associated with the highest number of these attributes in a single open space, but not with the total number of attributes in all POSs within 1.6 kilometers of home. Building 1 high-quality local park may be more effective in promoting recreational walking than is providing many average-quality parks.

A Monstrous Alliance: Open Architecture and Common Space

Directory of Open Access Journals (Sweden)

Gökhan Kodalak

2015-06-01

Full Text Available The contemporary built environment is absorbed by a dualist spatial organisation model divided between public and private space. Within this restrictive grammar, public space, despite its democratic promise, is heavily indoctrinated and anesthetised under the hegemony of regulatory apparatuses and control mechanisms, whereas private space has catalysed, if not directly engendered, prevalent spatial problems, such as ever-increasing slums, discriminatory gentrification and ecological catastrophes, despite its self-approving assurance. Underneath this dysfunctional couple lies common space, a third category that constitutes the shared spatial commonwealth of our entire natural and cultural milieu.The multitude, as an emerging body of self-organising political and spatial actors, has already started to unearth the potential of common space, actualising emergent and interactive spatial configurations all around the world. In this new, self-organisational model, architects do not become obsolete; rather, they leave behind their conventional roles as submissive experts and cosmetic speculators. By becoming anomalous architects, they affirm and augment the opening of spatial and architectural milieus to a myriad of new possibilities.This article theorises the possibility of a monstrous alliance between anomalous architects and the multitude, between open architectures and common space. Two specific case studies accompany these theoretical frameworks: the Gezi Event (Istanbul, 2013 demonstrates the actual emancipation of common space through the self-organising activity of the multitude, while Open-Cube (Antalya, 2013 attests to an early open architecture experiment based on the potentiating activity of the anomalous architect. 

A clinical investigation of force delivery systems for orthodontic space closure.

Science.gov (United States)

Nightingale, C; Jones, S P

2003-09-01

To investigate the force retention, and rates of space closure achieved by elastomeric chain and nickel titanium coil springs. Randomized clinical trial. Eastman Dental Hospital, London and Queen Mary's University Hospital, Roehampton, 1998-2000. Twenty-two orthodontic patients, wearing the pre-adjusted edgewise appliance undergoing space closure in opposing quadrants, using sliding mechanics on 0.019 x 0.025-inch posted stainless steel archwires. Medium-spaced elastomeric chain [Durachain, OrthoCare (UK) Ltd., Bradford, UK] and 9-mm nickel titanium coil springs [OrthoCare (UK) Ltd.] were placed in opposing quadrants for 15 patients. Elastomeric chain only was used in a further seven patients. The initial forces on placement and residual forces at the subsequent visit were measured with a dial push-pull gauge [Orthocare (UK) Ltd]. Study models of eight patients were taken before and after space closure, from which measurements were made to establish mean space closure. The forces were measured in grammes and space closure in millimetres. Fifty-nine per cent (31/53) of the elastomeric sample maintained at least 50 per cent of the initial force over a time period of 1-15 weeks. No sample lost all its force, and the mean loss was 47 per cent (range: 0-76 per cent). Nickel titanium coil springs lost force rapidly over 6 weeks, following that force levels plateaued. Forty-six per cent (12/26) maintained at least 50 per cent of their initial force over a time period of 1-22 weeks, and mean force loss was 48 per cent (range: 12-68 per cent). The rate of mean weekly space closure for elastomeric chain was 0.21 mm and for nickel titanium coil springs 0.26 mm. There was no relationship between the initial force applied and rate of space closure. None of the sample failed during the study period giving a 100 per cent response rate. In clinical use, the force retention of elastomeric chain was better than previously concluded. High initial forces resulted in high force decay

Open-Source RTOS Space Qualification: An RTEMS Case Study

Science.gov (United States)

Zemerick, Scott

2017-01-01

NASA space-qualification of reusable off-the-shelf real-time operating systems (RTOSs) remains elusive due to several factors notably (1) The diverse nature of RTOSs utilized across NASA, (2) No single NASA space-qualification criteria, lack of verification and validation (V&V) analysis, or test beds, and (3) different RTOS heritages, specifically open-source RTOSs and closed vendor-provided RTOSs. As a leader in simulation test beds, the NASA IV&V Program is poised to help jump-start and lead the space-qualification effort of the open source Real-Time Executive for Multiprocessor Systems (RTEMS) RTOS. RTEMS, as a case-study, can be utilized as an example of how to qualify all RTOSs, particularly the reusable non-commercial (open-source) ones that are gaining usage and popularity across NASA. Qualification will improve the overall safety and mission assurance of RTOSs for NASA-agency wide usage. NASA's involvement in space-qualification of an open-source RTOS such as RTEMS will drive the RTOS industry toward a more qualified and mature open-source RTOS product.

Green Open Space: Awareness for Health or Sustainability?

Science.gov (United States)

Dewi, O. C.; Chairunnisa, I.; Hidayat, T.; Anggraini, M.; Napitupulu, A.

2018-03-01

Universitas Indonesia in cooperation with American Red Cross and Indonesian Red Cross have been assisting green open space revitalisation program in 7 locations in Bogor Regency (2016-2017). The program was held under The Urban Disaster Risk Reduction Greater Jakarta Project; an initiative program from American Red Cross Indonesia. This project was not only improving the existing green open space quality, but also creating one adapted from public land. The revitalization project figures what happened on daily basis on the existing land, proposing new programming facilities, community-based construction, monitoring and handing over. This paper discovers the meaning of a green space for the community, whether the community aware of its benefit on human health or environmental sustainability. The research question is does the community aware of green open space benefit for human health or environmental sustainability? Or both? The original data from the community was gathered and grouped based on its relevance with environmental quality and public health.

Hydrogen disposal investigation for the Space Shuttle launch complex at Vandenberg Air Force Base

Science.gov (United States)

Breit, Terry J.; Elliott, George

1987-01-01

The concern of an overpressure condition on the aft end of the Space Shuttle caused by ignition of unburned hydrogen being trapped in the Space Shuttle Main Engine exhaust duct at the Vandenberg AFB launch complex has been investigated for fifteen months. Approximately twenty-five concepts have been reviewed, with four concepts being thoroughly investigated. The four concepts investigated were hydrogen burnoff ignitors (ignitors located throughout the exhaust duct to continuously ignite any unburned hydrogen), jet mixing (utilizing large volumes of high pressure air to ensure complete combustion of the hydrogen), steam inert (utilizing flashing hot water to inert the duct with steam) and open duct concept (design an open duct or above grade J-deflector to avoid trapping hydrogen gas). Extensive studies, analyses and testing were performed at six test sites with technical support from twenty-two major organizations. In December 1986, the Air Force selected the steam inert concept to be utilized at the Vandenberg launch complex and authorized the design effort.

Open superstring field theory on the restricted Hilbert space

International Nuclear Information System (INIS)

Konopka, Sebastian; Sachs, Ivo

2016-01-01

It appears that the formulation of an action for the Ramond sector of open superstring field theory requires to either restrict the Hilbert space for the Ramond sector or to introduce auxiliary fields with picture −3/2. The purpose of this note is to clarify the relation of the restricted Hilbert space with other approaches and to formulate open superstring field theory entirely in the small Hilbert space.

Open string T-duality in double space

International Nuclear Information System (INIS)

Sazdovic, B.

2017-01-01

The role of double space is essential in the new interpretation of T-duality and consequently in an attempt to construct M-theory. The case of the open string is missing in such an approach because until now there has been no appropriate formulation of open string T-duality. In the previous paper (Sazdovic, From geometry to non-geometry via T-duality, arXiv:1606.01938, 2017), we showed how to introduce vector gauge fields A"N_a and A"D_i at the end-points of an open string in order to enable open string invariance under local gauge transformations of the Kalb-Ramond field and its T-dual ''restricted general coordinate transformations''. We demonstrated that gauge fields A"N_a and A"D_i are T-dual to each other. In the present article we prove that all above results can be interpreted as coordinate permutations in double space. (orig.)

Open string T-duality in double space

Energy Technology Data Exchange (ETDEWEB)

Sazdovic, B. [University of Belgrade, Institute of Physics, Belgrade (Serbia)

2017-09-15

The role of double space is essential in the new interpretation of T-duality and consequently in an attempt to construct M-theory. The case of the open string is missing in such an approach because until now there has been no appropriate formulation of open string T-duality. In the previous paper (Sazdovic, From geometry to non-geometry via T-duality, arXiv:1606.01938, 2017), we showed how to introduce vector gauge fields A{sup N}{sub a} and A{sup D}{sub i} at the end-points of an open string in order to enable open string invariance under local gauge transformations of the Kalb-Ramond field and its T-dual ''restricted general coordinate transformations''. We demonstrated that gauge fields A{sup N}{sub a} and A{sup D}{sub i} are T-dual to each other. In the present article we prove that all above results can be interpreted as coordinate permutations in double space. (orig.)

Public evaluation of open space in Illinois: citizen support for natural area acquisition.

Science.gov (United States)

Backlund, Erik A; Stewart, William P; McDonald, Cary; Miller, Craig

2004-11-01

Numerous studies have indicated a broad-based support for open space preservation and protection. Research also has characterized the public values and rationale that underlie the widespread support for open space. In recognition of the widespread public support for open space, various levels of government have implemented programs to provide public access to open space. There are many different types of open space, ranging from golf courses, ball parks, wildlife areas, and prairies, to name a few. This paper addresses questions related to the types of open space that should be prioritized by planners and natural resource managers. The results of this study are based on a stratified random sample of 5000 households in Illinois that were sent a questionnaire related to their support for various types of open space. Through a comparatively simple action grid analysis, the open space types that should be prioritized for public access include forest areas, stream corridors, wildlife habitat, and lakes/ponds. These were the open space types rated of the highest importance, yet were also the open space types rated the lowest in respondent satisfaction. This kind of analysis does not require the technical expertise of other options for land-use prioritizations (e.g., conjoint analysis, contingent valuation), yet provides important policy directives for planners. Although open space funds often allow for purchase of developed sites such as golf courses, ball parks, and community parks, this study indicates that undeveloped (or nature-based) open space lands are most needed in Illinois.

Axial and Radial Forces of Cross-Bridges Depend on Lattice Spacing

Science.gov (United States)

Williams, C. David; Regnier, Michael; Daniel, Thomas L.

2010-01-01

Nearly all mechanochemical models of the cross-bridge treat myosin as a simple linear spring arranged parallel to the contractile filaments. These single-spring models cannot account for the radial force that muscle generates (orthogonal to the long axis of the myofilaments) or the effects of changes in filament lattice spacing. We describe a more complex myosin cross-bridge model that uses multiple springs to replicate myosin's force-generating power stroke and account for the effects of lattice spacing and radial force. The four springs which comprise this model (the 4sXB) correspond to the mechanically relevant portions of myosin's structure. As occurs in vivo, the 4sXB's state-transition kinetics and force-production dynamics vary with lattice spacing. Additionally, we describe a simpler two-spring cross-bridge (2sXB) model which produces results similar to those of the 4sXB model. Unlike the 4sXB model, the 2sXB model requires no iterative techniques, making it more computationally efficient. The rate at which both multi-spring cross-bridges bind and generate force decreases as lattice spacing grows. The axial force generated by each cross-bridge as it undergoes a power stroke increases as lattice spacing grows. The radial force that a cross-bridge produces as it undergoes a power stroke varies from expansive to compressive as lattice spacing increases. Importantly, these results mirror those for intact, contracting muscle force production. PMID:21152002

Ground reaction forces and knee kinetics during single and repeated badminton lunges.

Science.gov (United States)

Lam, Wing Kai; Ding, Rui; Qu, Yi

2017-03-01

Repeated movement (RM) lunge that frequently executed in badminton might be used for footwear evaluation. This study examined the influence of single movement (SM) and RM lunges on the ground reaction forces (GRFs) and knee kinetics during the braking phase of a badminton lunge step. Thirteen male university badminton players performed left-forward lunges in both SM and RM sessions. Force platform and motion capturing system were used to measure GRFs and knee kinetics variables. Paired t-test was performed to determine any significant differences between SM and RM lunges regarding mean and coefficient of variation (CV) in each variable. The kinetics results indicated that compared to SM lunges, the RM lunges had shorter contact time and generated smaller maximum loading rate of impact force, peak knee anterior-posterior force, and peak knee sagittal moment but generated larger peak horizontal resultant forces (Ps < 0.05). Additionally, the RM lunges had lower CV for peak knee medial-lateral and vertical forces (Ps < 0.05). These results suggested that the RM testing protocols had a distinct loading response and adaptation pattern during lunge and that the RM protocol showed higher within-trial reliability, which may be beneficial for the knee joint loading evaluation under different interventions.

Comparison of trial participants and open access users of a web-based physical activity intervention regarding adherence, attrition, and repeated participation.

Science.gov (United States)

Wanner, Miriam; Martin-Diener, Eva; Bauer, Georg; Braun-Fahrländer, Charlotte; Martin, Brian W

2010-02-10

Web-based interventions are popular for promoting healthy lifestyles such as physical activity. However, little is known about user characteristics, adherence, attrition, and predictors of repeated participation on open access physical activity websites. The focus of this study was Active-online, a Web-based individually tailored physical activity intervention. The aims were (1) to assess and compare user characteristics and adherence to the website (a) in the open access context over time from 2003 to 2009, and (b) between trial participants and open access users; and (2) to analyze attrition and predictors of repeated use among participants in a randomized controlled trial compared with registered open access users. Data routinely recorded in the Active-online user database were used. Adherence was defined as: the number of pages viewed, the proportion of visits during which a tailored module was begun, the proportion of visits during which tailored feedback was received, and the time spent in the tailored modules. Adherence was analyzed according to six one-year periods (2003-2009) and according to the context (trial or open access) based on first visits and longest visits. Attrition and predictors of repeated participation were compared between trial participants and open access users. The number of recorded visits per year on Active-online decreased from 42,626 in 2003-2004 to 8343 in 2008-2009 (each of six one-year time periods ran from April 23 to April 22 of the following year). The mean age of users was between 38.4 and 43.1 years in all time periods and both contexts. The proportion of women increased from 49.5% in 2003-2004 to 61.3% in 2008-2009 (Popen access users. For open access users, adherence was similar during the first and the longest visits; for trial participants, adherence was lower during the first visits and higher during the longest visits. Of registered open access users and trial participants, 25.8% and 67.3% respectively visited Active

The Quantum Space Phase Transitions for Particles and Force Fields

Directory of Open Access Journals (Sweden)

Chung D.-Y.

2006-07-01

Full Text Available We introduce a phenomenological formalism in which the space structure is treated in terms of attachment space and detachment space. Attachment space attaches to an object, while detachment space detaches from the object. The combination of these spaces results in three quantum space phases: binary partition space, miscible space and binary lattice space. Binary lattice space consists of repetitive units of alternative attachment space and detachment space. In miscible space, attachment space is miscible to detachment space, and there is no separation between attachment space and detachment spaces. In binary partition space, detachment space and attachment space are in two separat continuous regions. The transition from wavefunction to the collapse of wavefuction under interference becomes the quantum space phase transition from binary lattice space to miscible space. At extremely conditions, the gauge boson force field undergoes a quantum space phase transition to a "hedge boson force field", consisting of a "vacuum" core surrounded by a hedge boson shell, like a bubble with boundary.

Experimental Studies of Wheelchair and Walker Users Passing Through Doors with Different Opening Force.

Science.gov (United States)

Nersveen, Jonny

2016-01-01

Users of walkers and users of different categories of wheelchairs tested doors with different opening force, aiming to reveal the limit that these groups of people could manage on an everyday basis. 94.7% of the wheelchair users reported that a door opening force of 30 N was acceptable, while as 92.1% of this group described 40 N as acceptable. Similarly, 100% of the walker users reported that a door opening force of 30 N was acceptable, while as 87,5% of this group described 40 N as acceptable.

Universal design of public open spaces

Directory of Open Access Journals (Sweden)

Petra Krajner

2008-01-01

Full Text Available Urban open spaces are public places that must assure access for all users. They should be designed for equal use despite disabilities and special recreational needs. Their design must be functional and must meet user’s special requirements, either everyday functional or special (recreational needs. It is not just about overcoming architectural obstacles by building ramps of suitable slope and size; it is about inclusive, universal landscape design of urban space made for all citizens. For this matter, different ways of public use for each group of users is defined, functional criteria are determined, and examples of good and bad design are assembled to present the differences between technically accomplished ramps, and slope paths that include quality landscape inclusive design. To prove the unsuitability of public open spaces in Ljubljana, various analyses were made, including the measurement of steepness, lengths and wideness of certain urban elements. As an application of results, the universal designing principles are summarized in new proposal for entrance into Tivoli Park.

Technique for forcing high Reynolds number isotropic turbulence in physical space

Science.gov (United States)

Palmore, John A.; Desjardins, Olivier

2018-03-01

Many common engineering problems involve the study of turbulence interaction with other physical processes. For many such physical processes, solutions are expressed most naturally in physical space, necessitating the use of physical space solutions. For simulating isotropic turbulence in physical space, linear forcing is a commonly used strategy because it produces realistic turbulence in an easy-to-implement formulation. However, the method resolves a smaller range of scales on the same mesh than spectral forcing. We propose an alternative approach for turbulence forcing in physical space that uses the low-pass filtered velocity field as the basis of the forcing term. This method is shown to double the range of scales captured by linear forcing while maintaining the flexibility and low computational cost of the original method. This translates to a 60% increase of the Taylor microscale Reynolds number on the same mesh. An extension is made to scalar mixing wherein a scalar field is forced to have an arbitrarily chosen, constant variance. Filtered linear forcing of the scalar field allows for control over the length scale of scalar injection, which could be important when simulating scalar mixing.

Nanopuller-open data acquisition platform for AFM force spectroscopy experiments

International Nuclear Information System (INIS)

Pawlak, Konrad; Strzelecki, Janusz

2016-01-01

Atomic Force Microscope (AFM) is a widely used tool in force spectroscopy studies. Presently, this instrument is accessible from numerous vendors, albeit commercial solutions are expensive and almost always hardware and software closed. Approaches for open setups were published, as with modern low cost and readily available piezoelectric actuators, data acquisition interfaces and optoelectronic components building such force spectroscopy AFM is relatively easy. However, suitable software to control such laboratory made instrument was not released. Developing it in the lab requires significant time and effort. Our Nanopuller software described in this paper is intended to eliminate this obstacle. With only minimum adjustments this program can be used to control and acquire data with any suitable National Instruments universal digital/analog interface and piezoelectric actuator analog controller, giving significant freedom and flexibility in designing force spectroscopy experiment. Since the full code, written in a graphical LabVIEW environment is available, our Nanopuller can be easily customized. In this paper we describe the program and test its performance in controlling different setups. Successful and accurate force curve acquisition for standard samples (single molecules of I27O reference titin polyprotein and DNA as well as red blood cells) is shown. - Highlights: • We created open data acquisition software for performing Atomic Force Microscopy force measurements with custom laboratory made setups. • The software allows large flexibility in atomic force microscope design with minimum adjustment necessary. • The software is written in LabVIEW, allowing easy customization. • We successfully tested the program on two different hardware configurations by stretching single macromolecules and indenting cells.

Nanopuller-open data acquisition platform for AFM force spectroscopy experiments

Energy Technology Data Exchange (ETDEWEB)

Pawlak, Konrad; Strzelecki, Janusz

2016-05-15

Atomic Force Microscope (AFM) is a widely used tool in force spectroscopy studies. Presently, this instrument is accessible from numerous vendors, albeit commercial solutions are expensive and almost always hardware and software closed. Approaches for open setups were published, as with modern low cost and readily available piezoelectric actuators, data acquisition interfaces and optoelectronic components building such force spectroscopy AFM is relatively easy. However, suitable software to control such laboratory made instrument was not released. Developing it in the lab requires significant time and effort. Our Nanopuller software described in this paper is intended to eliminate this obstacle. With only minimum adjustments this program can be used to control and acquire data with any suitable National Instruments universal digital/analog interface and piezoelectric actuator analog controller, giving significant freedom and flexibility in designing force spectroscopy experiment. Since the full code, written in a graphical LabVIEW environment is available, our Nanopuller can be easily customized. In this paper we describe the program and test its performance in controlling different setups. Successful and accurate force curve acquisition for standard samples (single molecules of I27O reference titin polyprotein and DNA as well as red blood cells) is shown. - Highlights: • We created open data acquisition software for performing Atomic Force Microscopy force measurements with custom laboratory made setups. • The software allows large flexibility in atomic force microscope design with minimum adjustment necessary. • The software is written in LabVIEW, allowing easy customization. • We successfully tested the program on two different hardware configurations by stretching single macromolecules and indenting cells.

Measuring the quality of public open space using Google Earth.

Science.gov (United States)

Taylor, Bronwen T; Fernando, Peter; Bauman, Adrian E; Williamson, Anna; Craig, Jonathan C; Redman, Sally

2011-02-01

Proximity to public open space, such as parks and other green spaces, has considerable health benefits, and people have been shown to be more likely to use such space for physical activity if it is of high quality. This paper describes a new remote-assessment approach that makes use of Google Earth Pro (the free version of this program is Google Earth) to provide rapid and inexpensive measurement of the quality of public open space. The aim of the study was to assess the correlation between assessments of the quality of public open space using (1) the remote method (making use of Google Earth Pro) and (2) direct observation with a well-established measure of quality, the Public Open Space Tool (POST). Fifty parks selected from the southwest part of Sydney, Australia, were assessed in 2009 with the remote method (using Google Earth Pro), and scores were compared with those obtained from direct observation of the same parks using POST. The time taken to conduct the assessments using each method was also recorded. Raters for each method were blind to scores obtained from using the other method. Analyses were conducted in 2009. The Spearman correlation coefficient between the quality scores obtained for the 50 parks using the remote method and direct observation was 0.9 (pspaces without the need for in-person visits, dramatically reducing the time required for environmental audits of public open space. Copyright © 2011 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

Open source IPSEC software in manned and unmanned space missions

Science.gov (United States)

Edwards, Jacob

Network security is a major topic of research because cyber attackers pose a threat to national security. Securing ground-space communications for NASA missions is important because attackers could endanger mission success and human lives. This thesis describes how an open source IPsec software package was used to create a secure and reliable channel for ground-space communications. A cost efficient, reproducible hardware testbed was also created to simulate ground-space communications. The testbed enables simulation of low-bandwidth and high latency communications links to experiment how the open source IPsec software reacts to these network constraints. Test cases were built that allowed for validation of the testbed and the open source IPsec software. The test cases also simulate using an IPsec connection from mission control ground routers to points of interest in outer space. Tested open source IPsec software did not meet all the requirements. Software changes were suggested to meet requirements.

Novel Door-opening Method for Six-legged Robots Based on Only Force Sensing

Science.gov (United States)

Chen, Zhi-Jun; Gao, Feng; Pan, Yang

2017-09-01

Current door-opening methods are mainly developed on tracked, wheeled and biped robots by applying multi-DOF manipulators and vision systems. However, door-opening methods for six-legged robots are seldom studied, especially using 0-DOF tools to operate and only force sensing to detect. A novel door-opening method for six-legged robots is developed and implemented to the six-parallel-legged robot. The kinematic model of the six-parallel-legged robot is established and the model of measuring the positional relationship between the robot and the door is proposed. The measurement model is completely based on only force sensing. The real-time trajectory planning method and the control strategy are designed. The trajectory planning method allows the maximum angle between the sagittal axis of the robot body and the normal line of the door plane to be 45º. A 0-DOF tool mounted to the robot body is applied to operate. By integrating with the body, the tool has 6 DOFs and enough workspace to operate. The loose grasp achieved by the tool helps release the inner force in the tool. Experiments are carried out to validate the method. The results show that the method is effective and robust in opening doors wider than 1 m. This paper proposes a novel door-opening method for six-legged robots, which notably uses a 0-DOF tool and only force sensing to detect and open the door.

Public open space for disaster mitigation in Tangerang housing estates

Science.gov (United States)

Winandari, M. I. R.

2018-01-01

Public open space in housing estates plays an important role particularly in disaster mitigation. In some housing, there are indications of shape and use of space changes post-handover to local government. The aim of this study is to explore the relationship between public open space condition and management related to disaster mitigation in Tangerang housing estates. Multiple case study method is used to analyse of 2 housing cases. Aspects of access and boundaries were used to evaluate the cases. The results showed that gated community housing type should have more than 1 access to facilitate evacuation by considering the farthest unit to the housing gate. This is necessary to provide open spaces that are easily accessible from all units as the first evacuation site during and post disaster.

Distribution of green open space in Malang City based on multispectral data

Science.gov (United States)

Hasyim, A. W.; Hernawan, F. P.

2017-06-01

Green open space is one of the land that its existence is quite important in urban areas where the minimum area is set to reach 30% of the total area of the city. Malang which has an area of 110,6 square kilometers, is one of the major cities in East Java Province that is prone to over-land conversion due to development needs. In support of the green space program, calculation of green space is needed precisely so that remote sensing which has high accuracy is now used for measurement of green space. This study aims to analyze the area of green open space in Malang by using Landsat 8 image in 2015. The method used was the vegetation index that is Normalized Difference Vegetation Index (NDVI). From the study obtained the calculation of green open space was better to use the vegetation index method to avoid the occurrence of misclassification of other types of land use. The results of the calculation of green open space using NDVI found that the area of green open space in Malang City in 2015 reached 39% of the total area.

Numerical Analysis of Thermal Comfort at Open Air Spaces

Science.gov (United States)

Papakonstantinou, K.; Belias, C.; Pantos-Kikkos, S.; Assana, A.

2008-09-01

The present paper refers to the numerical simulation of air velocity at open air spaces and the conducting thermal comfort after the evaluation of the examined space using CFD methods, taking into account bioclimatic principles at the architectural design. More specially, the paper draws attention to the physical procedures governing air movement at an open environment area in Athens (urban park), named "Attiko Alsos," trying to form them in such way that will lead to the thermal comfort of the area's visitors. The study presents a mathematical model, implemented in a general computer code that can provide detailed information on velocity, prevailing in three-dimensional spaces of any geometrical complexity. Turbulent flow is simulated and buoyancy effects are taken into account. This modelling procedure is intended to contribute to the effort towards designing open areas, such as parks, squares or outdoor building environments, using thermal comfort criteria at the bioclimatic design. A computer model of this kind will provide the architects or the environmental engineers with powerful and economical means of evaluating alternative spaces' designs.

Courts and open spaces in the Late Helladic III Argolid

DEFF Research Database (Denmark)

Siennicka, Malgorzata

2015-01-01

While space remains a neglected subject in research on Mycenaean settlements, archaeological and ethnographical studies devoted to social meaning of places and areas used by the inhabitants of the prehistoric and other communities increase in number. This paper aims to review the use and signific......While space remains a neglected subject in research on Mycenaean settlements, archaeological and ethnographical studies devoted to social meaning of places and areas used by the inhabitants of the prehistoric and other communities increase in number. This paper aims to review the use...... and significance of courts and other open spaces in the Mycenaean settlements in the Argolid during the Palatial and Post-Palatial periods (c. 15th–11th centuries BC). Various categories of areas, like courts, open spaces and open-air areas are discussed, with an emphasis on their functions and status. Courts...

OpenSpace: From Data Visualization Research to Planetariums and Classrooms Worldwide

Science.gov (United States)

Emmart, C.; Ynnerman, A.; Bock, A.; Kuznetsova, M. M.; Kinzler, R. J.; Trakinski, V.; Mac Low, M. M.; Ebel, D. S. S.

2016-12-01

"OpenSpace" is a new NASA supported open source software that brings the latest techniques from data visualization research to the planetarium community and general public. The American Museum of Natural History (AMNH), in collaboration with informal science institutions (ISI), academic partners, key vendors that support planetariums worldwide, and NASA mission teams and Subject Matter Experts (SME), is creating OpenSpace to enable STEM education and improve U.S. scientific literacy by engaging a broad spectrum of the American public and STEM learners in cutting-edge NASA science and engineering content. The project's primary focus is the interactive presentation of dynamic data from observations (image sequences), astrophysical simulation (volumetric rendering), and space missions (observation geometry visualization). Development of the software began several years ago in collaboration with NASA Goddard's space weather modeling center and in conjunction with academic support from Linköping University (LiU) in Sweden, and continued last year with visualizations of NASA's New Horizons mission and ESA's Rosetta mission. For the New Horizons Pluto encounter, a dozen sites around the world running OpenSpace networked simultaneously to view the close approach to Pluto as narrated in real time by mission control scientists at NASA's Jet Propulsion Laboratory. Subsequent image data from the Long Range Reconnaissance Imaging (LORRI) camera was released by NASA as it downloaded from the spacecraft in the following months. These images, along with post encounter navigation reconstruction data (NASA SPICE) were then used to update the OpenSpace New Horizons visualization, and create a February 2016 public program in which Deputy Project Scientist, Cathy Olkin, demonstrated these results visualized in OpenSpace to a sold out crowd in the AMNH Hayden Planetarium. As demonstrated with the New Horizons visualization in OpenSpace, the goals of the project are to make visible

Factors related with public open space use among adolescents: a study using GPS and accelerometers.

Science.gov (United States)

Van Hecke, Linde; Verhoeven, Hannah; Clarys, Peter; Van Dyck, Delfien; Van de Weghe, Nico; Baert, Tim; Deforche, Benedicte; Van Cauwenberg, Jelle

2018-01-22

Low physical activity levels and high levels of sedentary time among adolescents call for population wide interventions. Public open spaces can be important locations for adolescents' physical activity. This study aimed to describe the prevalence, frequency and context of public open space visitation and to gain insight into the individual, social and physical environmental factors associated with public open space use among 12- to 16-year-old Flemish (Belgian) adolescents. Global positioning system devices, accelerometers and one-on-one interviews were used to measure location-specific activity levels, time spent at, reasons for using and accompaniment at public open spaces among 173 adolescents. Multilevel hurdle and gamma models were used to estimate the associations between the independent variables (age, gender, ethnicity, education, sport club membership and accompaniment) and the amount of time, sedentary time, light-, moderate- to vigorous- and vigorous-intensity physical activity at public open spaces. Three out of four participants had visited a public open space (for recreational purposes) and participants were most often accompanied by friends/classmates. Mainly public transportation stops/stations were used, and subsequently the most reported reason for public open space use was "to wait for something or someone". Furthermore, boys, younger adolescents, non-western-European adolescents and lower educated adolescents were more likely to use public open spaces. Additionally, boys and younger adolescents were more likely to accumulate physical activity at public open spaces. The only social environmental variable associated with time spent at public open spaces was accompaniment by siblings: adolescents spent more time at public open spaces when accompanied by their siblings. Public open spaces may be effective areas to promote physical activity among groups at risk for physical inactivity (i.e. low educated and non-western-European adolescents

Personal Spaces in Public Repositories as a Facilitator for Open Educational Resource Usage

Science.gov (United States)

Cohen, Anat; Reisman, Sorel; Sperling, Barbra Bied

2015-01-01

Learning object repositories are a shared, open and public space; however, the possibility and ability of personal expression in an open, global, public space is crucial. The aim of this study is to explore personal spaces in a big learning object repository as a facilitator for adoption of Open Educational Resources (OER) into teaching practices…

AtomicJ: An open source software for analysis of force curves

Science.gov (United States)

Hermanowicz, Paweł; Sarna, Michał; Burda, Kvetoslava; Gabryś, Halina

2014-06-01

We present an open source Java application for analysis of force curves and images recorded with the Atomic Force Microscope. AtomicJ supports a wide range of contact mechanics models and implements procedures that reduce the influence of deviations from the contact model. It generates maps of mechanical properties, including maps of Young's modulus, adhesion force, and sample height. It can also calculate stacks, which reveal how sample's response to deformation changes with indentation depth. AtomicJ analyzes force curves concurrently on multiple threads, which allows for high speed of analysis. It runs on all popular operating systems, including Windows, Linux, and Macintosh.

AtomicJ: An open source software for analysis of force curves

International Nuclear Information System (INIS)

Hermanowicz, Paweł; Gabryś, Halina; Sarna, Michał; Burda, Kvetoslava

2014-01-01

We present an open source Java application for analysis of force curves and images recorded with the Atomic Force Microscope. AtomicJ supports a wide range of contact mechanics models and implements procedures that reduce the influence of deviations from the contact model. It generates maps of mechanical properties, including maps of Young's modulus, adhesion force, and sample height. It can also calculate stacks, which reveal how sample's response to deformation changes with indentation depth. AtomicJ analyzes force curves concurrently on multiple threads, which allows for high speed of analysis. It runs on all popular operating systems, including Windows, Linux, and Macintosh

A strong open mapping theorem for surjections from cones onto Banach spaces

NARCIS (Netherlands)

Jeu, de M.F.E.; Messerschmidt, H.J.M.

2014-01-01

We show that a continuous additive positively homogeneous map from a closed not necessarily proper cone in a Banach space onto a Banach space is an open map precisely when it is surjective. This generalization of the usual Open Mapping Theorem for Banach spaces is then combined with Michael's

Open string fluctuations in AdS space with and without torsion

DEFF Research Database (Denmark)

Larsen, A.L.; Lomholt, Michael Andersen

2003-01-01

The equations of motion and boundary conditions for the fluctuations around a classical open string, in a curved space-time with torsion, are considered in compact and world-sheet covariant form. The rigidly rotating open strings in anti-de Sitter space with and without torsion are investigated...

Open problems in the geometry and analysis of Banach spaces

CERN Document Server

Guirao, Antonio J; Zizler, Václav

2016-01-01

This is a collection of some easily-formulated problems that remain open in the study of the geometry and analysis of Banach spaces. Assuming the reader has a working familiarity with the basic results of Banach space theory, the authors focus on concepts of basic linear geometry, convexity, approximation, optimization, differentiability, renormings, weak compact generating, Schauder bases and biorthogonal systems, fixed points, topology and nonlinear geometry. The main purpose of this work is to help convince young researchers in Functional Analysis that the theory of Banach spaces is a fertile field of research, full of interesting open problems. Inside the Banach space area, the text should help expose young researchers to the depth and breadth of the work that remains, and to provide the perspective necessary to choose a direction for further study. Some of the problems presented herein are longstanding open problems, some are recent, some are more important and some are only "local" problems. Some would ...

The relationship between jaw-opening force and the cross-sectional area of the suprahyoid muscles in healthy elderly.

Science.gov (United States)

Kajisa, E; Tohara, H; Nakane, A; Wakasugi, Y; Hara, K; Yamaguchi, K; Yoshimi, K; Minakuchi, S

2018-03-01

We conducted a clinical cross-sectional study to examine the relationship between jaw-opening force and the cross-sectional area of the suprahyoid muscles and whole skeletal muscle mass. Subjects were healthy 39 males and 51 females without dysphagia and sarcopenia, aged 65 years and older. Jaw-opening force was measured three times using a jaw-opening sthenometer; the maximum of these three was taken as the measurement value. The cross-sectional area of the geniohyoid and anterior belly of the digastric muscles were evaluated using ultrasonography. The skeletal muscle mass index, gait speed and grip strength were evaluated according to the diagnostic criteria of the Asian Working Group for Sarcopenia. For each sex, a multiple regression analysis determined the factors that affect jaw-opening force. Jaw-opening force was associated with the cross-sectional area of the geniohyoid muscle in males (regression coefficient [β] = 0.441, 95% confidence interval [CI] = 14.28-56.09) and females (β = 0.28, 95% CI = 3.10-54.57). Furthermore, in females only, jaw-opening force was associated with the skeletal muscle mass index (β = 0.40, 95% CI = 3.67-17.81). In contrast, jaw-opening force was not associated with the cross-sectional area of the anterior belly of the digastric muscle in either sex. In healthy elderly males and females, jaw-opening force was positively associated with the cross-sectional area of the geniohyoid muscle. However, the jaw-opening force was positively associated with the skeletal muscle mass index only in females. © 2017 John Wiley & Sons Ltd.

Automated genotyping of dinucleotide repeat markers

Energy Technology Data Exchange (ETDEWEB)

Perlin, M.W.; Hoffman, E.P. [Carnegie Mellon Univ., Pittsburgh, PA (United States)]|[Univ. of Pittsburgh, PA (United States)

1994-09-01

The dinucleotide repeats (i.e., microsatellites) such as CA-repeats are a highly polymorphic, highly abundant class of PCR-amplifiable markers that have greatly streamlined genetic mapping experimentation. It is expected that over 30,000 such markers (including tri- and tetranucleotide repeats) will be characterized for routine use in the next few years. Since only size determination, and not sequencing, is required to determine alleles, in principle, dinucleotide repeat genotyping is easily performed on electrophoretic gels, and can be automated using DNA sequencers. Unfortunately, PCR stuttering with these markers generates not one band for each allele, but a pattern of bands. Since closely spaced alleles must be disambiguated by human scoring, this poses a key obstacle to full automation. We have developed methods that overcome this obstacle. Our model is that the observed data is generated by arithmetic superposition (i.e., convolution) of multiple allele patterns. By quantitatively measuring the size of each component band, and exploiting the unique stutter pattern associated with each marker, closely spaced alleles can be deconvolved; this unambiguously reconstructs the {open_quotes}true{close_quotes} allele bands, with stutter artifact removed. We used this approach in a system for automated diagnosis of (X-linked) Duchenne muscular dystrophy; four multiplexed CA-repeats within the dystrophin gene were assayed on a DNA sequencer. Our method accurately detected small variations in gel migration that shifted the allele size estimate. In 167 nonmutated alleles, 89% (149/167) showed no size variation, 9% (15/167) showed 1 bp variation, and 2% (3/167) showed 2 bp variation. We are currently developing a library of dinucleotide repeat patterns; together with our deconvolution methods, this library will enable fully automated genotyping of dinucleotide repeats from sizing data.

76 FR 17474 - Commercial Space Transportation Advisory Committee-Open Meeting

Science.gov (United States)

2011-03-29

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation... Commercial Space Transportation Advisory Committee Open Meeting. SUMMARY: Pursuant to Section 10(a)(2) of the... the Commercial Space Transportation Advisory Committee (COMSTAC). The meeting will take place on...

77 FR 16891 - Commercial Space Transportation Advisory Committee-Open Meeting

Science.gov (United States)

2012-03-22

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation... Commercial Space Transportation Advisory Committee Open Meeting. SUMMARY: Pursuant to Section 10(a)(2) of the... the Commercial Space Transportation Advisory Committee (COMSTAC). The meeting will take place on...

78 FR 53496 - Commercial Space Transportation Advisory Committee; Open Meeting

Science.gov (United States)

2013-08-29

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation... Commercial Space Transportation Advisory Committee Open Meeting. SUMMARY: Pursuant to Section 10(a)(2) of the... the Commercial Space Transportation Advisory Committee (COMSTAC). The meeting will take place on...

76 FR 51461 - Commercial Space Transportation Advisory Committee-Open Meeting

Science.gov (United States)

2011-08-18

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation... Commercial Space Transportation Advisory Committee open meeting. SUMMARY: Pursuant to Section 10(a)(2) of the... the Commercial Space Transportation Advisory Committee (COMSTAC). The meeting will take place on...

78 FR 69742 - Commercial Space Transportation Advisory Committee-Open Meeting

Science.gov (United States)

2013-11-20

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation... Commercial Space Transportation Advisory Committee Open Meeting. SUMMARY: Pursuant to Section 10(a)(2) of the... the Commercial Space Transportation Advisory Committee (COMSTAC). The meeting will take place on...

77 FR 52108 - Commercial Space Transportation Advisory Committee; Open Meeting

Science.gov (United States)

2012-08-28

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation... Commercial Space Transportation Advisory Committee Open Meeting. SUMMARY: Pursuant to Section 10(a)(2) of the... the Commercial Space Transportation Advisory Committee (COMSTAC). The meeting will take place on...

75 FR 54002 - Commercial Space Transportation Advisory Committee-Open Meeting

Science.gov (United States)

2010-09-02

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation... Commercial Space Transportation Advisory Committee Open Meeting. SUMMARY: Pursuant to Section 10(a)(2) of the... the Commercial Space Transportation Advisory Committee (COMSTAC). The meeting will take place on...

78 FR 18416 - Commercial Space Transportation Advisory Committee; Open Meeting

Science.gov (United States)

2013-03-26

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation... Commercial Space Transportation Advisory Committee Open Meeting. SUMMARY: Pursuant to Section 10(a)(2) of the... the Commercial Space Transportation Advisory Committee (COMSTAC). The meeting will take place on...

Shear force bond analysis between acrylic resin bases and retention framework (open- and mesh-type)

Science.gov (United States)

Royhan, A.; Indrasari, M.; Masulili, C.

2017-08-01

Occlusions between teeth and the activity of the muscles around an artificial tooth during mastication create a force on dentures. This force causes friction between acrylic resin bases and retention frameworks that can lead to the complete loss of the acrylic resin base from the framework. The purpose of this study was to analyze the design of retention frameworks and determine which ones have a better resistance to shear forces in order to prevent the loss of heat cured acrylic resin base (HCARB). Six samples each of open-and mesh-type retention frameworks, both types made of Co-Cr material, and HCARB, were shear tested by means of a universal testing machine. The average shear force required to release the HCARB for mesh-type retention frameworks was 28.84 kgf, and the average for the open-type was 26.52 kgf. There was no significant difference between the shear forces required to remove HCARB from open- and mesh-type retention frameworks.

75 FR 16901 - Commercial Space Transportation Advisory Committee-Open Meeting

Science.gov (United States)

2010-04-02

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation... Commercial Space Transportation Advisory Committee Open meeting. SUMMARY: Pursuant to section 10(a)(2) of the... of the Commercial Space Transportation Advisory Committee (COMSTAC). The meetings will take place on...

Implementation of Space Charge Forces in BimBim

CERN Document Server

Gottlob, Emmanuel; Oeftiger, Adrian

An numerical algorithm is described for the implementation of linearised coherent space charge forces into BimBim, an eigenvalue solver for the coherent modes of oscillation of multibunch beams in the presence of beam coupling impedance, beam-beam, transverse feedback and now space charge effects. First results obtained with the model are described and compared to existing results where applicable.

The United States Space Force: Not If, But When

Science.gov (United States)

2016-06-01

the World View satellites and Falcon -9 rockets produced today by private companies are helping to forge a path to the heavens. In both of these... Rocket Force, Strategic Support Force. January 3. Accessed February 25, 2016. http://www.janes.com/article/56974/china-establishes-new- rocket -force...Betting Big on Space Warfare — Against China and Russia. February 12. Accessed February 12, 2016. https://news.vice.com/article/the-pentagon-is-betting

Evaluation of the effects of subgingival injection of Simvastatin on space re-opening after orthodontic space closure in adults.

Science.gov (United States)

Jahanbin, Arezoo; Abtahi, Mostafa; Namdar, Parastoo; Heravi, Farzin; Sadeghi, Fatemeh; Arab, Hamidreza; Shafaee, Hooman

2016-01-01

Background. This clinical trial evaluated the effect of Simvastatin on space re-opening after orthodontic space closure and its effect on the gingival index (GI) and clinical attachment loss (CAL). Methods. 16 females, 25-40 years old, with spaces between anterior mandibular teeth due to chronic periodontitis were participated in this study. The patients were randomly divided into control and experimental groups. In the experimental group, 1.2% Simvastatin gel and in the control group, 0.9% sodium chloride as a placebo was injected into the pocket depth of the six anterior teeth. The amount of space reopening, GI and CAL were measured. Results. No serious complications were observed during interventions and follow-up periods. Space re-opening was significantly reduced in patients receiving Simvastatin (P space re-opening after orthodontic space closure in human anterior teeth.

Cancellation of the centrifugal space-charge force

International Nuclear Information System (INIS)

Lee, E.P.

1990-01-01

The transverse dynamics of high-energy electrons confined in curved geometry are examined, including the effects of space-charge-induced fields. Attention is restricted to the centrifugal-space-charge force, which is the result of noncancellation of beam-induced transverse electric and magnetic fields in the curved geometry. This force is shown to be nearly cancelled in the evaluation of the horizontal tune and chromaticity by another, often overlooked term in the equation of motion. The additional term is the consequence of oscillations of the kinetic energy, which accompany betatron oscillations in the beam-induced electric potential. In curved geometry this term is of first order in the amplitude of the radial oscillation. A highly simplified system model is employed so that physical effects appear in as clear a form as possible. We assume azimuthal and median plane symmetry, static fields, and ultrarelativistic particle velocity (1/γ 2 ->0). (author) 9 refs

Open problems in Banach spaces and measure theory | Rodríguez ...

African Journals Online (AJOL)

We collect several open questions in Banach spaces, mostly related to measure theoretic aspects of the theory. The problems are divided into five categories: miscellaneous problems in Banach spaces (non-separable Lp spaces, compactness in Banach spaces, w*-null sequences in dual spaces), measurability in Banach ...

GREEN OPEN SPACE PERFORMANCE AS URBAN RECREASTION RESOURCES IN PEKANBARU

Directory of Open Access Journals (Sweden)

Wahyu Hidayat

2016-01-01

Full Text Available Urban green open space has significant benefits for the condition of urban living and its community. The availability of accessible and attractive green spaces for recreation activities is an integral part of urban quality of life. This research aims to assess the effectiveness of green open space provision as recreation resource for urban citizens in Pekanbaru, Indonesia. This study presents the assessment of two ele-ments which are equity and efficiency. These two elements are analyzed based on numerous independent variables such as number of the facil-ity, distance to house, accessibility and public transportation availability for equity assessment and frequency of usage, attractiveness of fa-cilities and safety level for efficiency assessment. The assessment of those variables is applied in three different subdistricts in Pekanbaru which are City Center, Sail and Tampan that represent different density categories. To achieve the objectives of this study, the method used to con-duct the study is field survey by questionnaire and interview. Stratified random sampling was the method used in data collection through the distribution of questionnaire, and the tool used to analyse data is through the Statistical Package for Social Science (SPSS. The data was analysed using descriptive statistics to obtain frequency distributions, percentage and the level of equity and efficiency. Several types of test in SPSS data analysis are included to attain some significant information in the study such as Chi-Square test of independence and analysis of Correlation. The findings indicate that a majority of respondents were not satisfied with the distribution of green open space. This study also identified that the quality of green open space facilities was perceived by residents as at moderate level. This survey results indicate that there is significant relationship between subdistricts of respondents and the satisfaction level of green open space

Criteria for Public Open Space Enhancement to Achieve Social Interaction: a Review Paper

Science.gov (United States)

Salih, S. A.; Ismail, S.

2017-12-01

A This paper presents a various literatures, studies, transcripts and papers aiming to provide an overview of some theories and existing research on the significance of natural environments and green open spaces to achieve social interaction and outdoor recreation. The main objective of the paper is to identify the factors that affecting social interaction in green open spaces, through proving that an appropriate open spaces is important to enhance social interaction and community. This study employs (qualitative) summarizing content analysis method which mainly focused on collect and summarizing of documentation such as transcripts, articles, papers, and books from more than 25 source, regarding the importance of public open spaces for the community. The summarizing content analysis of this paper is the fundament for a qualitative oriented procedure of text interpretation used to analyse the information gathered. Results of this study confirms that sound social interaction need an appropriate physical space including criteria of: design, activities, access and linkage, administration and maintenance, place attachment and users’ characteristics, also previous studies in this area have a health perspective with measures of physical activity of open spaces in general.

Phase space imaging of a beam of charged particles by frictional forces

International Nuclear Information System (INIS)

Daniel, H.

1977-01-01

In the case of frictional forces, defined by always acting opposite to the particle motion, Liouville's theorem does not apply. The effect of such forces on a beam of charged particles is calculated in closed form. Emphasis is given to the phase space imaging by a moderator. Conditions for an increase in phase space density are discussed. (Auth.)

An Open and Holistic Approach for Geo and Space Sciences

Science.gov (United States)

Ritschel, Bernd; Seelus, Christoph; Neher, Günther; Toshihiko, Iyemori; Yatagai, Akiyo; Koyama, Yukinobu; Murayama, Yasuhiro; King, Todd; Hughes, Steve; Fung, Shing; Galkin, Ivan; Hapgood, Mike; Belehaki, Anna

2016-04-01

Geo and space sciences thus far have been very successful, even often an open, cross-domain and holistic approach did not play an essential role. But this situation is changing rapidly. The research focus is shifting into more complex, non-linear and multi-domain specified phenomena, such as e.g. climate change or space environment. This kind of phenomena only can be understood step by step using the holistic idea. So, what is necessary for a successful cross-domain and holistic approach in geo and space sciences? Research and science in general become more and more dependent from a rich fundus of multi-domain data sources, related context information and the use of highly advanced technologies in data processing. Such buzzword phrases as Big Data and Deep Learning are reflecting this development. Big Data also addresses the real exponential growing of data and information produced by measurements or simulations. Deep Learning technology may help to detect new patterns and relationships in data describing high sophisticated natural phenomena. And further on, we should not forget science and humanities are only two sides of the same medal in the continuing human process of knowledge discovery. The concept of Open Data or in particular the open access to scientific data is addressing the free and open availability of -at least publicly founded and generated- data. The open availability of data covers the free use, reuse and redistribution of data which have been established with the formation of World Data Centers already more than 50 years ago. So, we should not forget, the foundation for open data is the responsibility of the individual scientist up until the big science institutions and organizations for a sustainable management of data. Other challenges are discovering and collecting the appropriate data, and preferably all of them or at least the majority of the right data. Therefore a network of individual or even better institutional catalog-based and at least

Public open space, physical activity, urban design and public health: Concepts, methods and research agenda.

Science.gov (United States)

Koohsari, Mohammad Javad; Mavoa, Suzanne; Villanueva, Karen; Sugiyama, Takemi; Badland, Hannah; Kaczynski, Andrew T; Owen, Neville; Giles-Corti, Billie

2015-05-01

Public open spaces such as parks and green spaces are key built environment elements within neighbourhoods for encouraging a variety of physical activity behaviours. Over the past decade, there has been a burgeoning number of active living research studies examining the influence of public open space on physical activity. However, the evidence shows mixed associations between different aspects of public open space (e.g., proximity, size, quality) and physical activity. These inconsistencies hinder the development of specific evidence-based guidelines for urban designers and policy-makers for (re)designing public open space to encourage physical activity. This paper aims to move this research agenda forward, by identifying key conceptual and methodological issues that may contribute to inconsistencies in research examining relations between public open space and physical activity. Copyright © 2015 Elsevier Ltd. All rights reserved.

Evaluation of the effects of subgingival injection of Simvastatin on space re-opening after orthodontic space closure in adults

Directory of Open Access Journals (Sweden)

Arezoo Jahanbin

2016-03-01

Full Text Available Background. This clinical trial evaluated the effect of Simvastatin on space re-opening after orthodontic space closure and its effect on the gingival index (GI and clinical attachment loss (CAL. Methods. 16 females, 25‒40 years old, with spaces between anterior mandibular teeth due to chronic periodontitis were participated in this study. The patients were randomly divided into control and experimental groups. In the experimental group, 1.2% Simvastatin gel and in the control group, 0.9% sodium chloride as a placebo was injected into the pocket depth of the six anterior teeth. The amount of space reopening, GI and CAL were measured. Results. No serious complications were observed during interventions and follow-up periods. Space re-opening was significantly reduced in patients receiving Simvastatin (P < 0.001. Moreover, GI reduction was significantly greater in Sim-vastatin group compared to the control group (P < 0.001. However, CAL did not demonstrate a significant difference between the groups. Conclusion. Simvastatin may decrease space re-opening after orthodontic space closure in human anterior teeth.

Next Generation Space Interconnect Standard (NGSIS): a modular open standards approach for high performance interconnects for space

Science.gov (United States)

Collier, Charles Patrick

2017-04-01

The Next Generation Space Interconnect Standard (NGSIS) effort is a Government-Industry collaboration effort to define a set of standards for interconnects between space system components with the goal of cost effectively removing bandwidth as a constraint for future space systems. The NGSIS team has selected the ANSI/VITA 65 OpenVPXTM standard family for the physical baseline. The RapidIO protocol has been selected as the basis for the digital data transport. The NGSIS standards are developed to provide sufficient flexibility to enable users to implement a variety of system configurations, while meeting goals for interoperability and robustness for space. The NGSIS approach and effort represents a radical departure from past approaches to achieve a Modular Open System Architecture (MOSA) for space systems and serves as an exemplar for the civil, commercial, and military Space communities as well as a broader high reliability terrestrial market.

Remaking Nigeria’s Urbanism: Assessing and Redressing the Dearth of Open Spaces in Benin City

Directory of Open Access Journals (Sweden)

Ndubisi Onwuanyi

2017-05-01

Full Text Available Unplanned land use in most Nigerian cities has meant that all urban land needs are not adequately provided for within their landscapes. Open spaces are either conspicuously missing or inadequate. There is a tendency for existing open spaces to be lost to urban development pressure and a disregard for zoning. This paper identifies available and accessible open spaces in Benin City and assesses their adequacy using as a guide standards established in two selected international jurisdictions, discusses the potential benefits of open space to the city on the one hand and its residents on the other given the incipient impacts of global warming and climate change, and the prospects of mitigation by greening the city even in its already built-up state. Data is sourced from journals, reports, archival records and inspections of the urban environment. The findings confirm a great dearth of open spaces as well as deteriorating urban environmental conditions which have implications for health, well-being and urban sustainability. The recommendations are that future expansions of the city space incorporate adequate provisions for open spaces, whilst within the existing built-up city, solutions be sought in the creation of greenways, green paths, private green spaces, promoting street trees and the conversion of brownfield sites to green areas.

The Impact of Green Open Space on Community Attachment—A Case Study of Three Communities in Beijing

Directory of Open Access Journals (Sweden)

Yuemei Zhu

2017-04-01

Full Text Available With the development of urbanization in China, the quality of urban life and community attachment have attracted increasing attention of the governments and society. Existing research on community attachment has mainly examined how individual characteristics affect community attachment, such as their length of residence and socioeconomic status. However, some scholars have become interested in exploring the effects of green open space on community attachment. This research examined whether the distribution of green open space in communities had significant effects on community attachment, and both the impact and path were also investigated. Through a questionnaire survey, relevant data in three communities of Beijing were collected. The impact of green open space layout on community attachment was evaluated by using hierarchical regression, and the impact path was examined by using a structural equation model. The results showed that green open space in a community had significant effects on the community attachment, with centralized green open space layout having a greater effect than that of dispersed green open space. Moreover, the more complex the shape of green open space is, the greater the impact is. The degree of satisfaction with the green open space had direct effects on the community attachment. The accessibility and perceived area of green open space could indirectly have an impact on the community attachment by affecting the degree of satisfaction with the green open space. Nevertheless, residents’ perceived importance of green open space could affect the community attachment directly and indirectly, as it affects the degree of satisfaction.

Modeling Force Transfer around Openings in Wood-Frame Shear Walls

Science.gov (United States)

Minghao Li; Frank Lam; Borjen Yeh; Tom Skaggs; Doug Rammer; James Wacker

2012-01-01

This paper presented a modeling study on force transfer around openings (FTAO) in wood-frame shear walls detailed for FTAO. To understand the load transfer in the walls, this study used a finite-element model WALL2D, which is able to model individual wall components, including framing members, sheathing panels, oriented panel-frame nailed connections, framing...

Effects of acute and repeated oral exposure to the organophosphate insecticide chlorpyrifos on open-field activity in chicks.

Science.gov (United States)

Al-Badrany, Y M A; Mohammad, F K

2007-11-01

The effects of the organophosphate insecticide chlorpyrifos on 5min open-field activity were examined in a 7-15 days old chick model. Chlorpyrifos was acutely administered taking into account cholinesterase inhibition and determination of the acute (24h) median lethal dose (LD50). The oral LD50 value of chlorpyrifos in chicks was 18.14mg/kg, with cholinergic toxicosis observed on intoxicated chicks. Chlorpyrifos at the dose rates of 5,10 and 20mg/kg orally produced within 2h signs of cholinergic toxicosis in the chicks and significantly inhibited plasma (40-70%), whole brain (43-69%) and liver (31-46%) cholinesterase activities in a dose-dependent manner. Chlorpyrifos at 2 and 4mg/kg, orally did not produce overt signs of cholinergic toxicosis, but decreased (30, 60 and 90min after dosing) the general locomotor activity of the chicks as seen by a significant increase in the latency to move from the central square of the open-field arena, decreases in the numbers of lines crossed and vocalization score. Repeated daily chlorpyrifos treatments (2 and 4mg/kg, orally) for seven consecutive days also caused hypoactivity in chicks in the open-field behavioral paradigm. Only the high dose of chlorpyrifos (4mg/kg, orally) given repeatedly for 7 days caused significant cholinesterase inhibition in the whole brain (37%) and the liver (22%). In conclusion, chlorpyrifos at single or short-term repeated doses-induced behavioral changes in 7-15 days old chicks, in a model that could be used for further neurobehavioral studies involving subtle effects of organophosphates on chicks.

Reactivation of Open Coil Springs: A Novel Procedure

Directory of Open Access Journals (Sweden)

Sanjeeb Kumar Sahu

2012-01-01

Full Text Available Open coil springs are commonly used in orthodontic practice to create space for a palatally or lingually blocked out tooth. However, very often the clinician encounters a situation where the inter-bracket span is very less and the open coil spring is not long enough to open the required space needed for alignment. In such situations, the clinician needs to remove the arch wire and reinserts a longer coil spring. A new simple and cost-effective technique describes an intraoral reactivation of an open coil spring without the need for removal of the base archwire with the additional benefit of preventing unwanted forces to the adjacent teeth.

The implications of force reflection for teleoperation in space

International Nuclear Information System (INIS)

Draper, J.V.; Herndon, J.N.; Moore, W.E.

1987-01-01

This paper reviews previous research on teleoperator force feedback and reports results of a testing program which assessed the impact of force reflection on teleoperator task performance. Force reflection is a type of force feedback in which the forces acting on the remote portion of the teleoperator are displayed to the operator by back-driving the master controller. The testing program compared three force reflection levels: 4 to 1 (four units of force on the slave produce one unit of force at the master controller), 1 to 1, and infinity to 1 (no force reflection). Time required to complete tasks, rate of occurrence of errors, the maximum force applied to tasks components, and variability in forces applied to components during completion of representative remote handling tasks were used as dependent variables. Operators exhibited lower error rates, lower peak forces, and more consistent application of forces using force reflection than they did without it. These data support the hypothesis that force reflection provides useful information for teleoperator users. The earlier literature and the results of the experiment are discussed in terms of their implications for space-based teleoperator systems. The discussion describes the impact of force reflection on task completion performance and task strategies, as suggested by the literature. It is important to understand the trade-offs involved in using telerobotic systems with and without force reflection. Force-reflecting systems are typically more expensive (in mass, volume, and price per unit), but they reduce mean time to repair and may be safer to use, compared to systems without force reflection

Repeated soil application of organic waste amendments reduces draught force and fuel consumption for soil tillage

DEFF Research Database (Denmark)

Peltrea, Clément; Nyord, Tavs; Bruun, Sander

2015-01-01

Abstract Soil application of organic waste products (OWP) can maintain or increase soil organic carbon (SOC) content, which in turn could lead to increased porosity and potentially to reduced energy use for soil tillage. Only a few studies have addressed the effect of SOC content on draught force...... for soil tillage, and this still needs to be addressed for fields that receive diverse types of organic waste of urban, agricultural and agro-industrial origin. The objective of this study was to determine the effect of changes in SOC induced by repeated soil application of OWP on draught force for soil...... tillage and tractor fuel consumption. Draught force was measured for tillage with conventional spring tillage tines, as well as bulk density, soil texture and SOC content in the CRUCIAL field experiment, Denmark in which diverse types of OWP had been applied annually for 11 years. The OWP included...

77 FR 8801 - Request for Applications: The Community Forest and Open Space Conservation Program

Science.gov (United States)

2012-02-15

... DEPARTMENT OF AGRICULTURE Forest Service Request for Applications: The Community Forest and Open Space Conservation Program AGENCY: Forest Service, USDA. ACTION: Request for applications. SUMMARY: The..., requests applications for the Community Forest and Open Space Conservation Program (Community Forest...

Butterflies Diversity in Brawijaya University, Veteran, Jakarta and Velodrom Green Open Space

Directory of Open Access Journals (Sweden)

Ayu Raisa Khairun Nisa'

2013-05-01

Full Text Available Butterflies have some roles in environmental as pollinator and bioindicator. Habitat is one of important factor to support butterflies growth. The aim of this research was to describe butterflies diversity in some green open spaces in Malang. Direct observations of butterflies diversity, vegetation structures and abiotic factors in Brawijaya University, Veteran, Jakarta and Velodrom Green Open Space were conducted on June 2012. Sampling was took place in each sites using cruising method in three times observation at 07.00, 11.00 a.m. and 3.30 p.m . Data were analyzed by statistical descriptive using Microsoft Excel 2007 and PAST. The result showed that butterflies composition in all sites dominated by Delias sp., Leptosia nina and Eurema venusta. The diversity index of all sites showed moderate rank that indicate communities equilibrium in environment was still good. In this case, Velodrom Green Open Space has the highest one of diversity index, it was about 2,199. Brawijaya University and Jakarta Green Open Space have a high similarity index based on Morisita Index. The highest abundance of butterflies was observed at 11.00-12.30 a.m. Delias sp. and Leptosia nina has temporal spread all day long, while Eurema venusta just in day light.

Public Open Spaces and Leisure-Time Walking in Brazilian Adults.

Science.gov (United States)

Florindo, Alex Antonio; Barrozo, Ligia Vizeu; Cabral-Miranda, William; Rodrigues, Eduardo Quieroti; Turrell, Gavin; Goldbaum, Moisés; Cesar, Chester Luiz Galvão; Giles-Corti, Billie

2017-05-23

Access to public open space is important to increase leisure-time walking (LTW) in high-income countries, but there is little evidence in middle-income countries. We conducted a cross-sectional analysis to examine the relationship between LTW and the presence of different public open spaces (parks, bike paths, and squares) and the mix of these recreational destinations near the homes of adults participating in the Sao Paulo Health Survey ( n = 3145). LTW was evaluated by a questionnaire. We delineated buffers (500, 1000, and 1500 m) from the geographic coordinates of the adults' residential addresses using a geographic information system. We used multilevel logistic regression taking account of clustering by census tracts and households, and with adjustment for social, demographics, and health characteristics. The main results showed that the presence of at least two recreational destinations within a 500-m buffer of participants' homes were associated with an increased odds of LTW compared with no destinations present (OR = 1.65; 95% CI 1.09-2.55). No associations were found for destinations further away. These results support actions outlined in the new urban plan for Sao Paulo city and could be used to highlight the importance access to a mix of public open spaces to promote physical activity in megacities of middle-income countries.

Space station operations task force. Panel 4 report: Management integration

Science.gov (United States)

1987-01-01

The Management Integration Panel of the Space Station Operations Task Force was chartered to provide a structure and ground rules for integrating the efforts of the other three panels and to address a number of cross cutting issues that affect all areas of space station operations. Issues addressed include operations concept implementation, alternatives development and integration process, strategic policy issues and options, and program management emphasis areas.

Stress energy of elastic globe in curved space and a slip-out force

International Nuclear Information System (INIS)

Sokolov, S.N.

1990-01-01

The energy of stresses in an elastic globe in the flat space and in curved space is expressed through scalar invariants of the curved space. This energy creates an additional force acting on elastic bodies in a gravitational field. 4 refs

Evidence-based severity assessment: Impact of repeated versus single open-field testing on welfare in C57BL/6J mice.

Science.gov (United States)

Bodden, Carina; Siestrup, Sophie; Palme, Rupert; Kaiser, Sylvia; Sachser, Norbert; Richter, S Helene

2018-01-15

According to current guidelines on animal experiments, a prospective assessment of the severity of each procedure is mandatory. However, so far, the classification of procedures into different severity categories mainly relies on theoretic considerations, since it is not entirely clear which of the various procedures compromise the welfare of animals, or, to what extent. Against this background, a systematic empirical investigation of the impact of each procedure, including behavioral testing, seems essential. Therefore, the present study was designed to elucidate the effects of repeated versus single testing on mouse welfare, using one of the most commonly used paradigms for behavioral phenotyping in behavioral neuroscience, the open-field test. In an independent groups design, laboratory mice (Mus musculus f. domestica) experienced either repeated, single, or no open-field testing - procedures that are assigned to different severity categories. Interestingly, testing experiences did not affect fecal corticosterone metabolites, body weights, elevated plus-maze or home cage behavior differentially. Thus, with respect to the assessed endocrinological, physical, and behavioral outcome measures, no signs of compromised welfare could be detected in mice that were tested in the open-field repeatedly, once, or, not at all. These findings challenge current classification guidelines and may, furthermore, stimulate systematic research on the severity of single procedures involving living animals. Copyright © 2017 Elsevier B.V. All rights reserved.

Evaluation of comfort conditions in urban open spaces. Application in the island of Crete

International Nuclear Information System (INIS)

Tsitoura, Marianna; Tsoutsos, Theocharis; Daras, Tryfon

2014-01-01

Highlights: • Outdoor spaces field surveys carried out in four different urban open spaces. • A strong connection between the microclimate and the use of open space. • Human physical and psychological factors can optimize the urban space design. - Abstract: The thermal environment in outdoor public spaces and their level of use are strongly connected. The design of outdoor spaces, especially in urban areas, is very critical in Southern Europe due to their extended use during summertime where the urban heat island phenomenon deteriorates the microclimatic conditions. In this paper the main outcomes of outdoor spaces field surveys are presented, which were carried out in four different urban open spaces in Crete. On site measurements were implemented and a questionnaire was used in order to estimate the thermal comfort of visitors. Thermal indices like Predicted Mean Vote, Physiologically Equivalent Temperature, Standard Effective Temperature, Wet Bulb Globe Temperature are used to evaluate the features of urban microclimate and then are being compared in order to find the most suitable for the Mediterranean microclimate. This suggests another way of approach to the researcher and provides essential tools to the designer

A Space Roadmap for the 21st Century Aerospace Force, Volume 1 Summary

National Research Council Canada - National Science Library

Borky, John

1998-01-01

.... While this report stands alone, it builds on the foundation of the Doable Space Quick-Look study led by the Air Force Chief Scientist and it complements the Aerospace Integration Task Force work...

A Comparison of Selective Auditory Attention Abilities in Open-Space Versus Closed Classroom Students.

Science.gov (United States)

Reinertsen, Gloria M.

A study compared performances on a test of selective auditory attention between students educated in open-space versus closed classroom environments. An open-space classroom environment was defined as having no walls separating it from hallways or other classrooms. It was hypothesized that the incidence of auditory figure-ground (ability to focus…

Open innovation in the European space sector : existing practices, constraints and opportunities

NARCIS (Netherlands)

van Burg, E.; Giannopapa, C.G.; Reymen, I.M.M.J.

2017-01-01

To enhance innovative output and societal spillover of the European space sector, the open innovation approach is becoming popular. Yet, open innovation, referring to innovation practices that cross borders of individual firms, faces constraints. To explore these constraints and identify

Ten Propositions Regarding Space Power: The Dawn of a Space Force

Science.gov (United States)

2006-01-01

perspective, space contributions z 97will account for an estimated $209 billion in 1947- 1950-T 1960-T 1970- 1980- 1990- the 2006 global economy. 2 4 50 60...Assessmu~t o ational awareiess, rhe transportation industry, A{,OaO{ dampaigns in 2010 and financial markers. 7TN PWOPSOI()S ] JWARII ’G SPA(E POWER 71...red, manner thot pmvteets one vital secnty intei blue, anI gray forces. The goal is rapid, acca - ests. We wil deter theati to our intrets, anid rate

Interactive human behavior analysis in open or public spaces

NARCIS (Netherlands)

Hung, H.; Odobez, J.-M.; Gavrila, D.; Keyson, D.V.; Maher, M.L.; Streitz, N.; Cheok, A.; Augusto, J.C.; Wichert, R.; Englebienne, G.; Aghajan, H.; Kröse, B.J.A.

2011-01-01

In the past years, efforts in surveillance and open space analysis have focused on traditional computer vision problems like scene modeling or object detection and tracking. Research on human behavior recognition have tended to work on predefined simple activities such as running, jumping or left

Public Open Spaces and Leisure-Time Walking in Brazilian Adults

Directory of Open Access Journals (Sweden)

Alex Antonio Florindo

2017-05-01

Full Text Available Access to public open space is important to increase leisure-time walking (LTW in high-income countries, but there is little evidence in middle-income countries. We conducted a cross-sectional analysis to examine the relationship between LTW and the presence of different public open spaces (parks, bike paths, and squares and the mix of these recreational destinations near the homes of adults participating in the Sao Paulo Health Survey (n = 3145. LTW was evaluated by a questionnaire. We delineated buffers (500, 1000, and 1500 m from the geographic coordinates of the adults’ residential addresses using a geographic information system. We used multilevel logistic regression taking account of clustering by census tracts and households, and with adjustment for social, demographics, and health characteristics. The main results showed that the presence of at least two recreational destinations within a 500-m buffer of participants’ homes were associated with an increased odds of LTW compared with no destinations present (OR = 1.65; 95% CI 1.09–2.55. No associations were found for destinations further away. These results support actions outlined in the new urban plan for Sao Paulo city and could be used to highlight the importance access to a mix of public open spaces to promote physical activity in megacities of middle-income countries.

Adaptation of the pituitary-adrenal axis to daily repeated forced swim exposure in rats is dependent on the temperature of water.

Science.gov (United States)

Rabasa, Cristina; Delgado-Morales, Raúl; Gómez-Román, Almudena; Nadal, Roser; Armario, Antonio

2013-11-01

Comparison of exposure to certain predominantly emotional stressors reveals a qualitatively similar neuroendocrine response profile as well as a reduction of physiological responses after daily repeated exposure (adaptation). However, particular physical components of the stressor may interfere with adaptation. As defective adaptation to stress can enhance the probability to develop pathologies, we studied in adult male rats (n = 10/group) swimming behavior (struggling, immobility and mild swim) and physiological responses (ACTH, corticosterone and rectal temperature) to daily repeated exposure to forced swim (20 min, 13 d) at 25 or 36 °C (swim25 or swim36). Rats were repeatedly blood-sampled by tail-nick and hormones measured by radioimmunoassay. Some differences were observed between the two swim temperature groups after the first exposure to forced swim: (a) active behaviors were greater in swim25 than swim36 groups; (b) swim25 but not swim36 caused hypothermia; and (c) swim36 elicited the same ACTH response as swim25, but plasma corticosterone concentration was lower for swim36 at 30 min post-swim. After daily repeated exposure, adaptation in ACTH secretion was observed with swim36 already on day 4, whereas with swim25 adaptation was not observed until day 13 and was of lower magnitude. Nevertheless, after repeated exposure to swim25 a partial protection from hypothermia was observed and the two swim conditions resulted in progressive reduction of active behaviors. Thus, daily repeated swim at 25 °C impairs adaptation of the hypothalamic-pituitary-adrenal axis as compared to swim at 36 °C, supporting the hypothesis that certain physical components of predominantly emotional stressors can interfere with the process of adaptation.

A portable Halbach magnet that can be opened and closed without force: the NMR-CUFF.

Science.gov (United States)

Windt, Carel W; Soltner, Helmut; van Dusschoten, Dagmar; Blümler, Peter

2011-01-01

Portable equipment for nuclear magnetic resonance (NMR) is becoming increasingly attractive for use in a variety of applications. One of the main scientific challenges in making NMR portable is the design of light-weight magnets that possess a strong and homogeneous field. Existing NMR magnets can provide such magnetic fields, but only for small samples or in small regions, or are rather heavy. Here we show a simple yet elegant concept for a Halbach-type permanent magnet ring, which can be opened and closed with minimal mechanical force. An analytical solution for an ideal Halbach magnet shows that the magnetic forces cancel if the structure is opened at an angle of 35.3° relative to its poles. A first prototype weighed only 3.1 kg, and provided a flux density of 0.57 T with a homogeneity better than 200 ppm over a spherical volume of 5mm in diameter without shimming. The force needed to close it was found to be about 20 N. As a demonstration, intact plants were imaged and water (xylem) flow measured. Magnets of this type (NMR-CUFF = Cut-open, Uniform, Force Free) are ideal for portable use and are eminently suited to investigate small or slender objects that are part of a larger or immobile whole, such as branches on a tree, growing fruit on a plant, or non-metallic tubing in industrial installations. This new concept in permanent-magnet design enables the construction of openable, yet strong and homogeneous magnets, which aside from use in NMR or MRI could also be of interest for applications in accelerators, motors, or magnetic bearings. Copyright © 2010 Elsevier Inc. All rights reserved.

Valuing urban open space using the travel-cost method and the implications of measurement error.

Science.gov (United States)

Hanauer, Merlin M; Reid, John

2017-08-01

Urbanization has placed pressure on open space within and adjacent to cities. In recent decades, a greater awareness has developed to the fact that individuals derive multiple benefits from urban open space. Given the location, there is often a high opportunity cost to preserving urban open space, thus it is important for both public and private stakeholders to justify such investments. The goals of this study are twofold. First, we use detailed surveys and precise, accessible, mapping methods to demonstrate how travel-cost methods can be applied to the valuation of urban open space. Second, we assess the degree to which typical methods of estimating travel times, and thus travel costs, introduce bias to the estimates of welfare. The site we study is Taylor Mountain Regional Park, a 1100-acre space located immediately adjacent to Santa Rosa, California, which is the largest city (∼170,000 population) in Sonoma County and lies 50 miles north of San Francisco. We estimate that the average per trip access value (consumer surplus) is $13.70. We also demonstrate that typical methods of measuring travel costs significantly understate these welfare measures. Our study provides policy-relevant results and highlights the sensitivity of urban open space travel-cost studies to bias stemming from travel-cost measurement error. Copyright © 2017 Elsevier Ltd. All rights reserved.

Space station operations task force. Panel 3 report: User development and integration

Science.gov (United States)

1987-01-01

The User Development and Integration Panel of the Space Station Operations Task Force was chartered to develop concepts relating to the operations of the Space Station manned base and the platforms, user accommodation and integration activities. The needs of the user community are addressed in the context with the mature operations phase of the Space Station. Issues addressed include space station pricing options, marketing strategies, payload selection and resource allocation options, and manifesting techniques.

Effect of the space-charge force on tracking at low energy

International Nuclear Information System (INIS)

Furman, M.A.

1987-01-01

The authors present tracking results for the SSC's Low Energy Booster at injection energy, including the effect of the space-charge force. The bunches are assumed to be gaussian with elliptical cross-section. Magnet errors and sextupoles are not included, but an RF cavity is. The authors compare the phase space with and without synchrotron oscillations, with and without space-charge. The effective emittance is not significantly altered. They also present results on tune shifts with amplitude

Perception of open urban space – Bevk square in Nova Gorica

Directory of Open Access Journals (Sweden)

Nataša Bratina

1997-01-01

Full Text Available In research on perception of open urban space, psychological and structural aspects are important, as well as social use. Social use however is most important, because open urban space and its green surfaces satisfies needs of an urban population. The psychological aspect applies to direct experiencing and perception of space, while the structural aspect proves that public urban places are an important category in the urban structure. On the example of Bevk square, Nova Gorica, three types of analyses were carried out. With the structural analysis and evaluation, development and structure of the place were shown, its problems and qualities. The survey on public opinion utilised the method of cognitive mapping, enabled definition of the image of the square, as perceived by everyday users. With the method of time samples events on the square were observed, in different time slots and days of the week.

An open source/real-time atomic force microscope architecture to perform customizable force spectroscopy experiments.

Science.gov (United States)

Materassi, Donatello; Baschieri, Paolo; Tiribilli, Bruno; Zuccheri, Giampaolo; Samorì, Bruno

2009-08-01

We describe the realization of an atomic force microscope architecture designed to perform customizable experiments in a flexible and automatic way. Novel technological contributions are given by the software implementation platform (RTAI-LINUX), which is free and open source, and from a functional point of view, by the implementation of hard real-time control algorithms. Some other technical solutions such as a new way to estimate the optical lever constant are described as well. The adoption of this architecture provides many degrees of freedom in the device behavior and, furthermore, allows one to obtain a flexible experimental instrument at a relatively low cost. In particular, we show how such a system has been employed to obtain measures in sophisticated single-molecule force spectroscopy experiments [Fernandez and Li, Science 303, 1674 (2004)]. Experimental results on proteins already studied using the same methodologies are provided in order to show the reliability of the measure system.

Jaw-opening force test to screen for Dysphagia: preliminary results.

Science.gov (United States)

Hara, Koji; Tohara, Haruka; Wada, Satoko; Iida, Takatoshi; Ueda, Koichiro; Ansai, Toshihiro

2014-05-01

To assess the jaw-opening force test (JOFT) for dysphagia screening. Criterion standard. University dental hospital. Patients complaining of dysphagia (N=95) and with symptoms of dysphagia with chronic underlying causes (mean age ± SD, 79.3±9.61y; range, 50-94y; men: n=49; mean age ± SD, 77.03±9.81y; range, 50-94y; women: n=46; mean age ± SD, 75.42±9.73y; range, 51-93y) admitted for treatment between May 2011 and December 2012 were included. None. All patients were administered the JOFT and underwent fiberoptic endoscopic evaluation of swallowing (FEES). The mean jaw-opening strength was compared with aspiration (ASP) and pharyngeal residue observations of the FEES, which was used as the criterion standard. A receiver operating characteristic (ROC) curve analysis was performed. Forces of ≤3.2kg for men and ≤4kg for women were appropriate cutoff values for predicting ASP with a sensitivity and specificity of .57 and .79 for men and .93 and .52 for women, respectively. Based on the ROC analyses for predicting pharyngeal residue, forces of ≤5.3kg in men and ≤3.9kg in women were appropriate cutoff values, with a sensitivity and specificity of .80 and .88 for men and .83 and .81 for women, respectively. The JOFT could be a useful screening tool for predicting pharyngeal residue and could provide useful information to aid in the referral of patients for further diagnostic imaging testing. However, given its low sensitivity to ASP the JOFT should be paired with other screening tests that predict ASP. Copyright © 2014 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Move the Neighborhood: study design of a community-based participatory public open space intervention

DEFF Research Database (Denmark)

Pawlowski, Charlotte Skau; Winge, Laura; Carroll, Sidse

evaluation will be used to gain knowledge of the intervention processes. DISCUSSION: The study presents new methods and approaches in the field of public open space interventions through interdisciplinary collaboration, participatory co-design approach and combination of measurements. Using both effect......BACKGROUND: A limited amount of research has examined the effect of changing public open spaces on active living. This abstract presents the study protocol of an intervention study designed in an interdisciplinary collaboration built on principles of Community-Based Participatory Research (CBPR...... and process evaluations the study will provide unique insights in the role and importance of the interdisciplinary collaboration, participatory processes, tailoring changes in public open space to local needs and wishes. These results can be used to guide urban renewal projects in deprived neighbourhoods...

Low force cementation.

Science.gov (United States)

Wilson, P R

1996-07-01

The marginal adaptation of full coverage restorations is adversely affected by the introduction of luting agents of various minimum film thicknesses during the cementation process. The increase in the marginal opening may have long-term detrimental effects on the health of both pulpal and periodontal tissues. The purpose of this study was to determine the effects of varying seating forces (2.5, 12.5, 25 N), venting, and cement types on post-cementation marginal elevation in cast crowns. A standardized cement space of 40 microns was provided between a machined gold crown and a stainless steel die. An occlusal vent was placed that could be opened or closed. The post-cementation crown elevation was measured, following the use of two commercially available capsulated dental cements (Phosphacap, and Ketac-cem Applicap). The results indicate that only the combination of Ketac-Cem Applicap and crown venting produced post-cementation crown elevation of less than 20 microns when 12.5 N seating force was used. Higher forces (25 N) and venting were required for comparable seating when using Phosphacap (19 microns). The amount of force required to allow maximum seating of cast crowns appears to be cement specific, and is reduced by effective venting procedures.

Open-loop control of quasiperiodic thermoacoustic oscillations

Science.gov (United States)

Guan, Yu; Gupta, Vikrant; Kashinath, Karthik; Li, Larry K. B.

2017-11-01

The open-loop application of periodic acoustic forcing has been shown to be a potentially effective strategy for controlling periodic thermoacoustic oscillations, but its effectiveness on aperiodic thermoacoustic oscillations is less clear. In this experimental study, we apply periodic acoustic forcing to a ducted premixed flame oscillating quasiperiodically at two incommensurate natural frequencies, f1 and f2. We find that (i) above a critical forcing amplitude, the system locks into the forcing by oscillating only at the forcing frequency ff, producing a closed periodic orbit in phase space with no evidence of the original T2 torus attractor; (ii) the critical forcing amplitude required for lock-in decreases as ff approaches either f1 or f2, resulting in characteristic ∨-shaped lock-in boundaries around the two natural modes; and (iii) for a wide range of forcing frequencies, the system's oscillation amplitude can be reduced to less than 20% of that of the unforced system. These findings show that the open-loop application of periodic acoustic forcing can be an effective strategy for controlling aperiodic thermoacoustic oscillations. This work was supported by the Research Grants Council of Hong Kong (Project No. 16235716 and 26202815).

Open Education as a Way for Space Education in Russia

Science.gov (United States)

Malyshev, V. V.; Karp, K. A.

2002-01-01

low level of state financial support. As a result there is a decreasing education quality. Scientific research was always an integral part of education and an alternative way for education financial support. But today the level of such support is too low as well. High experience of Russian space education system is not useful completely. This paper shows, that at present an open education could be a new step of space education in Russia. discussed in the paper. of students per one professor and also the number of students, which pay for education. New technology based on Internet technology would provide high methodology and technical level of education. The open education guarantees training in different areas and specialties on international standard level. education process, new education technology, new equipment of education system, new ways of financial support, international cooperation in education process, new professors and staffs in education system, increasing the level of salary for staff and comfortable conditions for students are discussed at the first. free education period, both traditional and new education methods are very important on the other side. about 4-5 years. The necessity of international educational system integration has to be taken into account. The international standard request, educational courses in different languages and free market conditions have to be under consideration. The partially ready open space education is discussed also. That system can be started even today.

The Role of Open Space in Urban Neighbourhoods for Health-Related Lifestyle

Science.gov (United States)

Lestan, Katarina Ana; Eržen, Ivan; Golobič, Mojca

2014-01-01

The research reported in this paper addresses the relationship between quality of open space and health related lifestyle in urban residential areas. The research was performed in the residential developments in Ljubljana, Slovenia, dating from the time of political and economic changes in the early nineties. Compared to the older neighborhoods, these are typically single-use residential areas, with small open spaces and poor landscape design. The research is concerned with the quality of life in these areas, especially from the perspective of the vulnerable users, like the elderly and children. Both depend on easily accessible green areas in close proximity to their homes. The hypothesis is that the poor open space quality affects their health-related behavior and their perceived health status. The research has three methodological phases: (1) a comparison between urban residential areas by criteria describing their physical characteristics; (2) behavior observation and mapping and (3) a resident opinion survey. The results confirm differences between open spaces of the selected residential areas as well as their relation with outdoor activities: a lack of outdoor programs correlates with poor variety of outdoor activities, limited to transition type, less time spent outdoors and lower satisfaction with their home environment. The survey also disclosed a strong influence of a set of socio-economic variables such as education and economic status on physical activity and self-perceived health status of people. The results therefore confirm the hypothesis especially for less affluent and educated; i.e., vulnerable groups. PMID:25003173

The Role of Open Space in Urban Neighbourhoods for Health-Related Lifestyle

Directory of Open Access Journals (Sweden)

Katarina Ana Lestan

2014-06-01

Full Text Available The research reported in this paper addresses the relationship between quality of open space and health related lifestyle in urban residential areas. The research was performed in the residential developments in Ljubljana, Slovenia, dating from the time of political and economic changes in the early nineties. Compared to the older neighborhoods, these are typically single-use residential areas, with small open spaces and poor landscape design. The research is concerned with the quality of life in these areas, especially from the perspective of the vulnerable users, like the elderly and children. Both depend on easily accessible green areas in close proximity to their homes. The hypothesis is that the poor open space quality affects their health-related behavior and their perceived health status. The research has three methodological phases: (1 a comparison between urban residential areas by criteria describing their physical characteristics; (2 behavior observation and mapping and (3 a resident opinion survey. The results confirm differences between open spaces of the selected residential areas as well as their relation with outdoor activities: a lack of outdoor programs correlates with poor variety of outdoor activities, limited to transition type, less time spent outdoors and lower satisfaction with their home environment. The survey also disclosed a strong influence of a set of socio-economic variables such as education and economic status on physical activity and self-perceived health status of people. The results therefore confirm the hypothesis especially for less affluent and educated; i.e., vulnerable groups.

Impact of Location of the Central Activities on Development of Open Public Space in the City Centers of Small Cities

Directory of Open Access Journals (Sweden)

Volgemut, Mateja

2016-10-01

Full Text Available Urban areas of the central activities with mixed land use are crucial for the development of city center, even in small cities. In the last decades or two the attention is drawn on the retail and service activities that are usually located outside of cities near main roads. Municipalities had already detected this problem, but they are not implementing any of the measures (Rebernik, 2010. The purpose of this paper is to demonstrate that the central activities in small cities in Slovenia are located in freestanding buildings, which is most appropriate in terms of forming the open public space in the city center. In this research we compared ten central activities (Vrišer, 1988, 1990, Kokole, 1971 in 34 small cities. We selected only those small cities (Prosen et al, 2008 which have among other activities a county court. The results showed the differences and commonalities of the central activities in selected small cities according to the indicators. Litija, Domžale and Sevnica are small cities, where activities that could articulate open public space are located in the larger building complexes. The phenomenon is similar to a modern machine, where action in it and indirectly the insight into the functioning of the society is invisible to the observer (Kos, 2008. We found out that in these tree cities the central activities are not forming the open public spaces in front of the public buildings (Vertelj Nared, 2014. The result is problematic image of the city and changed forces of the city life.

Generalizations of γ-open set in topological spaces

Energy Technology Data Exchange (ETDEWEB)

Bhattacharya, Baby, E-mail: babybhatt75@gmail.com; Paul, Arnab, E-mail: mrarnabpaul87@gmail.com [Department of Mathematics, NIT Agartala, Jirania, Tripura (India)

2016-06-21

The main aim of this work is to study three generalized forms of γ-open set due to D. Andrijevic (D. Andrijevic, On the Topology Generated by pre-open sets, Presented at the Sixth Prague Topological Symposium, 39 (1987), 367-376)in a topological space. Out of which the dual appearance of one is the stronger form of b-locally closed set in the sense of Arafa A. Nasef (A. A Nasef,On b-locally closed sets and related topics, CHAOS SOLITONS & FRACTALS 12(2001) 1909-1915). Also, we introduce the concept of different types of continuity and study their basic properties by using these newly defined sets. Finally, we establish the interrelationships among themselves together with some already existing generalized forms of continuity.

Compound list: gentamicin [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available gentamicin GMC 00147 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/gentam...icin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/gentam...at/in_vivo/Liver/Repeat/gentamicin.Rat.in_vivo.Liver.Repeat.zip ftp://ftp.bioscie...ncedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/gentamicin.Rat.in_vivo.Kidney.Single.zip ftp...://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Repeat/gentamicin.Rat.in_vivo.Kidney.Repeat.zip ...

Finding the Middle Ground: The U.S. Air Force, Space Weaponization, and Arms Control

National Research Council Canada - National Science Library

Ruhm, Brian

2003-01-01

.... US development of an Expeditionary Space Force (ESF) would be one element of a comprehensive strategy that would include changes to US space architecture and cooperative measures with other countries...

Transfer closed and transfer open multimaps in minimal spaces

International Nuclear Information System (INIS)

Alimohammady, M.; Roohi, M.; Delavar, M.R.

2009-01-01

This paper is devoted to introduce the concepts of transfer closed and transfer open multimaps in minimal spaces. Also, some characterizations of them are considered. Further, the notion of minimal local intersection property will be introduced and characterized. Moreover, some maximal element theorems via minimal transfer closed multimaps and minimal local intersection property are given.

Einstein's dream : the space-time unification of fundamental forces

Energy Technology Data Exchange (ETDEWEB)

Salam, A [International Centre for Theoretical Physics, Trieste (Italy)

1981-06-01

The historical developments in physics which started with Galileo in the 11th century, Newton in the 17 century, culminated in the unification of space-time by Einstein in this century are traced. The theories put forward by Einstein himself and by subsequent workers in the field after him, regarding the unification of all basic forces of nature (i.e.) the electromagnetic and the gravitational ones and the weak and strong nuclear forces are discussed. The experiments being conducted in Kolar and other places to detect a heavier photon which would be a positive proof of the validity of the unification theory, are touched upon. The possible application of this concept even in industry has been pointed out.

Researching on Hawking Effect in a Kerr Space Time via Open Quantum System Approach

International Nuclear Information System (INIS)

Liu, Wen-Biao; Liu, Xian-Ming

2014-01-01

It has been proposed that Hawking radiation from a Schwarzschild or a de Sitter spacetime can be understood as the manifestation of thermalization phenomena in the framework of an open quantum system. Through examining the time evolution of a detector interacting with vacuum massless scalar fields, it is found that the detector would spontaneously excite with a probability the same as the thermal radiation at Hawking temperature. Following the proposals, the Hawking effect in a Kerr space time is investigated in the framework of an open quantum systems. It is shown that Hawking effect of the Kerr space time can also be understood as the the manifestation of thermalization phenomena via open quantum system approach. Furthermore, it is found that near horizon local conformal symmetry plays the key role in the quantum effect of the Kerr space time

The effect of nonlinear forces on coherently oscillating space-charge-dominated beams

International Nuclear Information System (INIS)

Celata, C.M.

1987-03-01

A particle-in-cell computer simulation code has been used to study the transverse dynamics of nonrelativistic misaligned space-charge-dominated coasting beams in an alternating gradient focusing channel. In the presence of nonlinear forces due to dodecapole or octupole imperfections of the focusing fields or to image forces, the transverse rms emittance grows in a beat pattern. Analysis indicates that this emittance dilution is due to the driving of coherent modes of the beam near their resonant frequencies by the nonlinear force. The effects of the dodecapole and images forces can be made to effectively cancel for some boundary conditions, but the mechanism is not understood at this time

Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects

Directory of Open Access Journals (Sweden)

GILDA NEVES

2017-08-01

Full Text Available ABSTRACT Immobility time in the forced swimming has been described as analogous to emotional blunting or apathy and has been used for characterizing schizophrenia animal models. Several clinical studies support the use of NMDA receptor antagonists to model schizophrenia in rodents. Some works describe the effects of ketamine on immobility behavior but there is variability in the experimental design used leading to controversial results. In this study, we evaluated the effects of repeated administration of ketamine sub-anesthetic doses in forced swimming, locomotion in response to novelty and novel object recognition, aiming a broader evaluation of the usefulness of this experimental approach for modeling schizophrenia in mice. Ketamine (30 mg/kg/day i.p. for 14 days induced a not persistent decrease in immobility time, detected 24h but not 72h after treatment. This same administration protocol induced a deficit in novel object recognition. No change was observed in mice locomotion. Our results confirm that repeated administration of sub-anesthetic doses of ketamine is useful in modeling schizophrenia-related behavioral changes in mice. However, the immobility time during forced swimming does not seem to be a good endpoint to evaluate the modeling of negative symptoms in NMDAR antagonist animal models of schizophrenia.

Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects.

Science.gov (United States)

Neves, Gilda; Borsoi, Milene; Antonio, Camila B; Pranke, Mariana A; Betti, Andresa H; Rates, Stela M K

2017-01-01

Immobility time in the forced swimming has been described as analogous to emotional blunting or apathy and has been used for characterizing schizophrenia animal models. Several clinical studies support the use of NMDA receptor antagonists to model schizophrenia in rodents. Some works describe the effects of ketamine on immobility behavior but there is variability in the experimental design used leading to controversial results. In this study, we evaluated the effects of repeated administration of ketamine sub-anesthetic doses in forced swimming, locomotion in response to novelty and novel object recognition, aiming a broader evaluation of the usefulness of this experimental approach for modeling schizophrenia in mice. Ketamine (30 mg/kg/day i.p. for 14 days) induced a not persistent decrease in immobility time, detected 24h but not 72h after treatment. This same administration protocol induced a deficit in novel object recognition. No change was observed in mice locomotion. Our results confirm that repeated administration of sub-anesthetic doses of ketamine is useful in modeling schizophrenia-related behavioral changes in mice. However, the immobility time during forced swimming does not seem to be a good endpoint to evaluate the modeling of negative symptoms in NMDAR antagonist animal models of schizophrenia.

Synergistic enhancement of cellulase pairs linked by consensus ankyrin repeats: Determination of the roles of spacing, orientation, and enzyme identity.

Science.gov (United States)

Cunha, Eva S; Hatem, Christine L; Barrick, Doug

2016-08-01

Biomass deconstruction to small simple sugars is a potential approach to biofuels production; however, the highly recalcitrant nature of biomass limits the economic viability of this approach. Thus, research on efficient biomass degradation is necessary to achieve large-scale production of biofuels. Enhancement of cellulolytic activity by increasing synergism between cellulase enzymes holds promise in achieving high-yield biofuels production. Here we have inserted cellulase pairs from extremophiles into hyperstable α-helical consensus ankyrin repeat domain scaffolds. Such chimeric constructs allowed us to optimize arrays of enzyme pairs against a variety of cellulolytic substrates. We found that endocellulolytic domains CelA (CA) and Cel12A (C12A) act synergistically in the context of ankyrin repeats, with both three and four repeat spacing. The extent of synergy differs for different substrates. Also, having C12A N-terminal to CA provides greater synergy than the reverse construct, especially against filter paper. In contrast, we do not see synergy for these enzymes in tandem with CelK (CK) catalytic domain, a larger exocellulase, demonstrating the importance of enzyme identity in synergistic enhancement. Furthermore, we found endocellulases CelD and CA with three repeat spacing to act synergistically against filter paper. Importantly, connecting CA and C12A with a disordered linker of similar contour length shows no synergistic enhancement, indicating that synergism results from connecting these domains with folded ankyrin repeats. These results show that ankyrin arrays can be used to vary spacing and orientation between enzymes, helping to design and optimize artificial cellulosomes, providing a novel architecture for synergistic enhancement of enzymatic cellulose degradation. Proteins 2016; 84:1043-1054. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Compound list: allyl alcohol [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available allyl alcohol AA 00010 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/allyl_alcohol....Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/allyl_alcohol...dbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/allyl_alcohol.Rat.in_vivo.Liver.Repeat.zip ftp:/.../ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/allyl_alcohol.Rat.in_vivo.Kidney....Single.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Repeat/allyl_alcohol.Rat.in_vivo.Kidney.Repeat.zip ...

The effect of space charge force on beams extracted from ECR ion sources

International Nuclear Information System (INIS)

Xie, Z.Q.

1989-01-01

A new 3 dimensional ray tracing code BEAM-3D, with a simple model to calculate the space charge force of multiple ion species, is under development and serves as a theoretical tool to study the ECRIS beam formation. Excellent agreement between the BEAM-3D calculations and beam profile and emittance measurements of the total extracted helium 1+ beam from the RTECR ion source was obtained when a low degree of beam neutralization was assumed in the calculations. The experimental evidence indicates that the positive space charge effects dominate the early RTECR ion source beam formation and beamline optics matching process. A review of important beam characteristics is made, including a conceptual model for the space charge beam blow up. Better beam transport through the RTECR beamline analysis magnet has resulted after an extraction geometry modification in which the space charge force was more correctly matched. This work involved the development of an online beam characteristic measuring apparatus which will also be described

State-Space Realization of the Wave-Radiation Force within FAST: Preprint

Energy Technology Data Exchange (ETDEWEB)

Duarte, T.; Sarmento, A.; Alves, M.; Jonkman, J.

2013-06-01

Several methods have been proposed in the literature to find a state-space model for the wave-radiation forces. In this paper, four methods were compared, two in the frequency domain and two in the time domain. The frequency-response function and the impulse response of the resulting state-space models were compared against the ones derived by the numerical code WAMIT. The implementation of the state-space module within the FAST offshore wind turbine computer-aided engineering (CAE) tool was verified, comparing the results against the previously implemented numerical convolution method. The results agreed between the two methods, with a significant reduction in required computational time when using the state-space module.

How to Cope with Working in an Open-space Lab?

NARCIS (Netherlands)

Pautasso, Marco; Werf, van der Wopke

2017-01-01

Open-space labs and research environments are increasingly common worldwide. They are supposed to facilitate interactions among researchers, but can be disruptive to those who need to be in a quiet environment in order to concentrate. This problem is increasingly felt across the natural, medical

Thermal Performance of Housing Open Spaces in the City of Mosul

Directory of Open Access Journals (Sweden)

Dr. TURKI HASAN ALI ALHADIDI

2012-03-01

Full Text Available The rapid urban growth has lead to an urgent need to increase residential buildings in such a way that requires quick execution of such buildings. The appearance of modern materials such as reinforced concrete has helped in getting fast-constructed houses of a westerly pattern such that excluding the inherited styles that are in harmony with severe environment like that of the Middle East. This has resulted in a modern pattern of buildings lacks the microclimate which was enjoyed by the traditional pattern and which have provided the inhabitant with a relative thermal comfort. ‎This research try to compare different microclimates due to the variation of open architectural spaces patterns in the residential units (traditional ones represented by (the courtyards and Iwan and the modem one represented by the space of (garages and terraces in Summer in Mosul city. ‎ ‎The results showed that the traditional open spaces are the nearest to the thermal comfort zone, although both of them don't represent the ideal state of human comfort in this ‎period of Summer.

Repeated rat-forced swim test: reducing the number of animals to evaluate gradual effects of antidepressants.

Science.gov (United States)

Mezadri, T J; Batista, G M; Portes, A C; Marino-Neto, J; Lino-de-Oliveira, C

2011-02-15

The forced swim test (FST) is a pre-clinical test to short and long term treatment with antidepressant drugs (ADT), which requires between-subject designs. Herein a modified protocol of the FST using within-subject design (repeated rat-FST) was evaluated. Male Wistar rats were submitted to 15 min of swimming (Day 1: pretest) followed by three subsequent 5 min-swimming tests one week apart (Day 2: test, Day 7: retest 1, Day 14: retest 2). To determine the temporal and factorial characteristics of the variables scored in the repeated rat-FST, the protocol was carried out in untreated animals (E1). To validate the method, daily injections of Fluoxetine (FLX, 2.5mg/kg, i.p.) or saline were given over a 2-week period (E2). Tests and retests have been videotaped for further register of the latency, frequency and duration of behaviors. Over retesting the latency to immobility decreased whereas duration of immobility tended to increase. Factorial analysis revealed that the test, the retest 1 as well as the retest 2 have variables suitable to detection of antidepressant-like effects of ADT. Compared to saline, FLX chronically administrated reduced duration of immobility whereas increased duration of swimming in retest 2. The data suggest that repeated rat-FST detected the gradual increase in the efficacy of low doses of FLX over time. Therefore, repeated rat-FST seemed suitable to detect short and long term effects of selective serotonin reuptake inhibitors, or other ADT, thus reducing the number of animals used in the screenings of this type of compounds. © 2010 Elsevier B.V. All rights reserved.

On the Value of Foregone Open Space in Sprawling Cities

NARCIS (Netherlands)

Vermeulen, W.; Rouwendal, J.

2014-01-01

Foregone benefits of the open space that is sacrificed through urban sprawl are hard to quantify. We obtain a simple benchmark measure by introducing a demand for trips beyond the urban boundary into the monocentric city model. The externality arises from the increase in travel costs that expansion

Open branes in space-time non-commutative little string theory

International Nuclear Information System (INIS)

Harmark, T.

2001-01-01

We conjecture the existence of two new non-gravitational six-dimensional string theories, defined as the decoupling limit of NS5-branes in the background of near-critical electrical two- and three-form RR fields. These theories are space-time non-commutative Little String Theories with open branes. The theory with (2,0) supersymmetry has an open membrane in the spectrum and reduces to OM theory at low energies. The theory with (1,1) supersymmetry has an open string in the spectrum and reduces to (5+1)-dimensional NCOS theory for weak NCOS coupling and low energies. The theories are shown to be T-dual with the open membrane being T-dual to the open string. The theories therefore provide a connection between (5+1)-dimensional NCOS theory and OM theory. We study the supergravity duals of these theories and we consider a chain of dualities that shows how the T-duality between the two theories is connected with the S-duality between (4+1)-dimensional NCOS theory and OM theory

Design and implementation of a novel modal space active force control concept for spatial multi-DOF parallel robotic manipulators actuated by electrical actuators.

Science.gov (United States)

Yang, Chifu; Zhao, Jinsong; Li, Liyi; Agrawal, Sunil K

2018-01-01

Robotic spine brace based on parallel-actuated robotic system is a new device for treatment and sensing of scoliosis, however, the strong dynamic coupling and anisotropy problem of parallel manipulators result in accuracy loss of rehabilitation force control, including big error in direction and value of force. A novel active force control strategy named modal space force control is proposed to solve these problems. Considering the electrical driven system and contact environment, the mathematical model of spatial parallel manipulator is built. The strong dynamic coupling problem in force field is described via experiments as well as the anisotropy problem of work space of parallel manipulators. The effects of dynamic coupling on control design and performances are discussed, and the influences of anisotropy on accuracy are also addressed. With mass/inertia matrix and stiffness matrix of parallel manipulators, a modal matrix can be calculated by using eigenvalue decomposition. Making use of the orthogonality of modal matrix with mass matrix of parallel manipulators, the strong coupled dynamic equations expressed in work space or joint space of parallel manipulator may be transformed into decoupled equations formulated in modal space. According to this property, each force control channel is independent of others in the modal space, thus we proposed modal space force control concept which means the force controller is designed in modal space. A modal space active force control is designed and implemented with only a simple PID controller employed as exampled control method to show the differences, uniqueness, and benefits of modal space force control. Simulation and experimental results show that the proposed modal space force control concept can effectively overcome the effects of the strong dynamic coupling and anisotropy problem in the physical space, and modal space force control is thus a very useful control framework, which is better than the current joint

A two dimensional fibre reinforced micropolar thermoelastic problem for a half-space subjected to mechanical force

Directory of Open Access Journals (Sweden)

Ailawalia Praveen

2015-01-01

Full Text Available The purpose of this paper is to study the two dimensional deformation of fibre reinforced micropolar thermoelastic medium in the context of Green-Lindsay theory of thermoelasticity. A mechanical force is applied along the interface of fluid half space and fibre reinforced micropolar thermoelastic half space. The normal mode analysis has been applied to obtain the exact expressions for displacement component, force stress, temperature distribution and tangential couple stress. The effect of anisotropy and micropolarity on the displacement component, force stress, temperature distribution and tangential couple stress has been depicted graphically.

B-type natriuretic peptide (BNP serum levels in rats after forced repeated swimming stress

Directory of Open Access Journals (Sweden)

Almira Hadžovic-Džuvo

2011-02-01

Full Text Available Aim To estimate the effects of forced repeated swimming stress on BNP serum levels in rats. Methods Adult male Wistar rats weighting between 280-330 g were divided into two groups: control group (n =8 and stress group (n =8. Rats in the stress group were exposed to forced swimming stress daily, for 7 days. The rats were forced to swim in plastic tanks (90 cm wide, 120 cm deep containing tap water (temperature ca. 25°C. The depth of water was 40 cm. Duration of each swimming session progressively increased from 10 minutes on the irst day to 40 minutes on days 6 and 7. Rats were sacriiced and blood was drawn from abdominal aorta for BNP analysis immediately after the last swimming session. B-type natriuretic serum level was determined by ELISA method using RAT BNP-32 kit (Phoenix Pharmaceutical Inc.. Results There was no statistically signiicant difference between mean BNP serum level in the stress group after the swimming period (0.81±0.14 ng/ml as compared to the unstressed group of rats (0.8 ±0.08ng/ml. After the swimming period mean body weight slightly decreased in the stress group in comparison with values before stress period (296.3 g vs.272.8 g, but this difference was not statistically signiicant. The stress period had no inluence on food intake in the stress rat group. Conclusion The workload consisting of 40-minutes long swimming session is not suficient to provoke BNP release from myocardium in rats.

B-type natriuretic peptide (BNP) serum levels in rats after forced repeated swimming stress.

Science.gov (United States)

Hadzovic-Dzuvo, Almira; Valjevac, Amina; Avdagić, Nesina; Lepara, Orhan; Zaćiragić, Asija; Jadrić, Radivoj; Alajbegović, Jasmin; Prnjavorac, Besim

2011-02-01

To estimate the effects of forced repeated swimming stress on BNP serum levels in rats. Adult male Wistar rats weighting between 280-330 g were divided into two groups: control group (n = 8) and stress group (n = 8). Rats in the stress group were exposed to forced swimming stress daily, for 7 days. The rats were forced to swim in plastic tanks (90 cm wide, 120 cm deep) containing tap water (temperature ca. 25 degrees C). The depth of water was 40 cm. Duration of each swimming session progressively increased from 10 minutes on the first day to 40 minutes on days 6 and 7. Rats were sacrificed and blood was drawn from abdominal aorta for BNP analysis immediately after the last swimming session. B-type natriuretic serum level was determined by ELISA method using RAT BNP-32 kit (Phoenix Pharmaceutical Inc.). There was no statistically significant difference between mean BNP serum level in the stress group after the swimming period (0.81 +/- 0.14 ng/ml) as compared to the unstressed group of rats (0.8 +/- 0.08 ng/ml). After the swimming period mean body weight slightly decreased in the stress group in comparison with values before stress period (296.3 g vs. 272.8 g), but this difference was not statistically significant. The stress period had no influence on food intake in the stress rat group. The workload consisting of 40-minutes long swimming session is not sufficient to provoke BNP release from myocardium in rats.

Casimir force in the Goedel space-time and its possible induced cosmological inhomogeneity

Energy Technology Data Exchange (ETDEWEB)

Khodabakhshi, Sh. [University of Tehran, Department of Physics, Tehran (Iran, Islamic Republic of); Shojai, A. [University of Tehran, Department of Physics, Tehran (Iran, Islamic Republic of); Institute for Research in Fundamental Sciences (IPM), Foundations of Physics Group, School of Physics, Tehran (Iran, Islamic Republic of)

2017-07-15

The Casimir force between two parallel plates in the Goedel universe is computed for a scalar field at finite temperature. It is observed that when the plates' separation is comparable with the scale given by the rotation of the space-time, the force becomes repulsive and then approaches zero. Since it has been shown previously that the universe may experience a Goedel phase for a small period of time, the induced inhomogeneities from the Casimir force are also studied. (orig.)

Effects of repeated simulated removal activities on feral swine movements and space use

Science.gov (United States)

Fischer, Justin W.; McMurtry , Dan; Blass, Chad R.; Walter, W. David; Beringer, Jeff; VerCauterren, Kurt C.

2016-01-01

Abundance and distribution of feral swine (Sus scrofa) in the USA have increased dramatically during the last 30 years. Effective measures are needed to control and eradicate feral swine populations without displacing animals over wider areas. Our objective was to investigate effects of repeated simulated removal activities on feral swine movements and space use. We analyzed location data from 21 feral swine that we fitted with Global Positioning System harnesses in southern MO, USA. Various removal activities were applied over time to eight feral swine before lethal removal, including trapped-and-released, chased with dogs, chased with hunter, and chased with helicopter. We found that core space-use areas were reduced following the first removal activity, whereas overall space-use areas and diurnal movement distances increased following the second removal activity. Mean geographic centroid shifts did not differ between pre- and post-periods for either the first or second removal activities. Our information on feral swine movements and space use precipitated by human removal activities, such as hunting, trapping, and chasing with dogs, helps fill a knowledge void and will aid wildlife managers. Strategies to optimize management are needed to reduce feral swine populations while preventing enlarged home ranges and displacing individuals, which could lead to increased disease transmission risk and human-feral swine conflict in adjacent areas.

Fiber Bragg grating sensor for simultaneous measurement of temperature and force using polymer open loop

Science.gov (United States)

Huang, Yonglin; Zhang, Shiyan

2014-07-01

A fiber Bragg grating (FBG) sensor for simultaneous measurement of temperature and force is proposed and demonstrated. Where a part of uniform FBG (about one half length of an FBG) is attached on the polymer open loop, the FBG is divided into two parts which has an equal length. So the two parts can be regarded as two FBGs. Because of the difference of the Young's modulus and the thermal expansion coefficients for two parts of the FBG, the two Bragg reflection wavelengths are shift when the temperature and force are applied on the sensor. Simultaneous measurement of temperature and force is demonstrated experimentally. The experimental results show that the linear response to temperature and force are achieved. The value of applied temperature and force can be obtained from the two Bragg wavelength shift via the coefficient matrix. This study provides a simple and economical method to measure temperature and force simultaneously.

Development of a Refined Space Vehicle Rollout Forcing Function

Science.gov (United States)

James, George; Tucker, Jon-Michael; Valle, Gerard; Grady, Robert; Schliesing, John; Fahling, James; Emory, Benjamin; Armand, Sasan

2016-01-01

For several decades, American manned spaceflight vehicles and the associated launch platforms have been transported from final assembly to the launch pad via a pre-launch phase called rollout. The rollout environment is rich with forced harmonics and higher order effects can be used for extracting structural dynamics information. To enable this utilization, processing tools are needed to move from measured and analytical data to dynamic metrics such as transfer functions, mode shapes, modal frequencies, and damping. This paper covers the range of systems and tests that are available to estimate rollout forcing functions for the Space Launch System (SLS). The specific information covered in this paper includes: the different definitions of rollout forcing functions; the operational and developmental data sets that are available; the suite of analytical processes that are currently in-place or in-development; and the plans and future work underway to solve two immediate problems related to rollout forcing functions. Problem 1 involves estimating enforced accelerations to drive finite element models for developing design requirements for the SLS class of launch vehicles. Problem 2 involves processing rollout measured data in near real time to understand structural dynamics properties of a specific vehicle and the class to which it belongs.

Investigating the Impact of Schools' Open Space on Learning and Educational Achievement of Elementary Students

Directory of Open Access Journals (Sweden)

Abdolreza Gilavand

2016-04-01

Full Text Available Background It is obvious that most of informal learnings of social skills and constructive plays occur in school yards and play-fields where children spend much of their non-official time of teaching. This study aimed to investigate the impact of schools' open space on learning and educational achievement of elementary students in Ahvaz, Southwest of Iran. Materials and Methods At a cross-sectional study, 210 students were selected randomly as sample of study. Data collection tools included Hermance’s achievement motivation questionnaire and researcher-constructed questionnaire (observation checklist to examine the physical parameters of learning schools' open space and interviews with students. Data of study were analyzed in SPSS- 21 software. Results Results of this study showed that schools' open space has a significant impact on learning and academic achievement of elementary school students in Ahvaz- Iran (P

History, rare, and multiple events of mechanical unfolding of repeat proteins

Science.gov (United States)

Sumbul, Fidan; Marchesi, Arin; Rico, Felix

2018-03-01

Mechanical unfolding of proteins consisting of repeat domains is an excellent tool to obtain large statistics. Force spectroscopy experiments using atomic force microscopy on proteins presenting multiple domains have revealed that unfolding forces depend on the number of folded domains (history) and have reported intermediate states and rare events. However, the common use of unspecific attachment approaches to pull the protein of interest holds important limitations to study unfolding history and may lead to discarding rare and multiple probing events due to the presence of unspecific adhesion and uncertainty on the pulling site. Site-specific methods that have recently emerged minimize this uncertainty and would be excellent tools to probe unfolding history and rare events. However, detailed characterization of these approaches is required to identify their advantages and limitations. Here, we characterize a site-specific binding approach based on the ultrastable complex dockerin/cohesin III revealing its advantages and limitations to assess the unfolding history and to investigate rare and multiple events during the unfolding of repeated domains. We show that this approach is more robust, reproducible, and provides larger statistics than conventional unspecific methods. We show that the method is optimal to reveal the history of unfolding from the very first domain and to detect rare events, while being more limited to assess intermediate states. Finally, we quantify the forces required to unfold two molecules pulled in parallel, difficult when using unspecific approaches. The proposed method represents a step forward toward more reproducible measurements to probe protein unfolding history and opens the door to systematic probing of rare and multiple molecule unfolding mechanisms.

Using observational methods to evaluate public open spaces and physical activity in Brazil.

Science.gov (United States)

Hino A A, F; Reis, Rodrigo S; Ribeiro, Isabela C; Parra, Diana C; Brownson, Ross C; Fermino, Rogerio C

2010-07-01

Open public spaces have been identified as important facilities to promote physical activity (PA) at the community level. The main goals of this study are to describe open public spaces user's characteristics and to explore to what extent these characteristics are associated with PA behavior. A system of direct observation was used to evaluate the PA levels on parks and squares (smaller parks) and users's characteristics (gender and age). The 4 parks and 4 squares observed were selected from neighborhoods with different socioeconomic status and environmental characteristics. The settings were observed 3 times a day, 6 days per week, during 2 weeks. More men than women were observed in parks (63.1%) and squares (70.0%) as well as more adults and adolescents than older adults and children. Users were more physically active in parks (men = 34.1%, women = 36.1%) than in squares (men = 25.5%, women 22.8%). The characteristics of public open spaces may affect PA in the observed places. Initiatives to improve PA levels in community settings should consider users' characteristics and preferences to be more effective and reach a larger number of people.

The Role of Stakeholders Related to the Management of Ecological Function of Urban Green Open Space. Case Study: City of Depok, Indonesia

Science.gov (United States)

Mangopa Malik, Andy Anton

2017-12-01

Urban green open space is one of the assets that provide substantial benefits to the urban community. One important function of urban green open space is a function of ecology. This study will provide initial explanation on the various studies related to the ecological function of urban green open space. The study of urban space management approach related to ecological function will explain the extent of the role of stakeholders in the urban areas that will further strengthen the importance of the existence of green open space, especially in city of Depok. With so many problems related to the supply and use of green open space in the city of Depok. This approach was originally applied by the private sector and many applications made a great contribution, so it began to be used by the government in managing public assets there. This study will use descriptive method, at the beginning of the study will explain the existence of the reality of urban green open space as part of the urban space by viewing it from theoretical overview of space, function and role of the various problems that occur in it. The results of this study indicate there are six problems in the management of green open spaces in city of Depok. Using the stages in asset management will provide space for participation of existing stakeholders in the management of green open spaces in city of Depok.

Evaluation of sampling, cookery, and shear force protocols for objective evaluation of lamb longissimus tenderness.

Science.gov (United States)

Shackelford, S D; Wheeler, T L; Koohmaraie, M

2004-03-01

Experiments were conducted to compare the effects of two cookery methods, two shear force procedures, and sampling location within non-callipyge and callipyge lamb LM on the magnitude, variance, and repeatability of LM shear force data. In Exp. 1, 15 non-callipyge and 15 callipyge carcasses were sampled, and Warner-Bratzler shear force (WBSF) was determined for both sides of each carcass at three locations along the length (anterior to posterior) of the LM, whereas slice shear force (SSF) was determined for both sides of each carcass at only one location. For approximately half the carcasses within each genotype, LM chops were cooked for a constant amount of time using a belt grill, and chops of the remaining carcasses were cooked to a constant endpoint temperature using open-hearth electric broilers. Regardless of cooking method and sampling location, repeatability estimates were at least 0.8 for LM WBSF and SSF. For WBSF, repeatability estimates were slightly higher at the anterior location (0.93 to 0.98) than the posterior location (0.88 to 0.90). The difference in repeatability between locations was probably a function of a greater level of variation in shear force at the anterior location. For callipyge LM, WBSF was higher (P lamb LM chops cooked with the belt grill using a larger number of animals (n = 87). In Exp. 2, LM chops were obtained from matching locations of both sides of 44 non-callipyge and 43 callipyge carcasses. Chops were cooked with a belt grill and SSF was measured, and repeatability was estimated to be 0.95. Repeatable estimates of lamb LM tenderness can be achieved either by cooking to a constant endpoint temperature with electric broilers or cooking for a constant amount of time with a belt grill. Likewise, repeatable estimates of lamb LM tenderness can be achieved with WBSF or SSF. However, use of belt grill cookery and the SSF technique could decrease time requirements which would decrease research costs.

Openly Published Environmental Sensing (OPEnS) | Advancing Open-Source Research, Instrumentation, and Dissemination

Science.gov (United States)

Udell, C.; Selker, J. S.

2017-12-01

The increasing availability and functionality of Open-Source software and hardware along with 3D printing, low-cost electronics, and proliferation of open-access resources for learning rapid prototyping are contributing to fundamental transformations and new technologies in environmental sensing. These tools invite reevaluation of time-tested methodologies and devices toward more efficient, reusable, and inexpensive alternatives. Building upon Open-Source design facilitates community engagement and invites a Do-It-Together (DIT) collaborative framework for research where solutions to complex problems may be crowd-sourced. However, barriers persist that prevent researchers from taking advantage of the capabilities afforded by open-source software, hardware, and rapid prototyping. Some of these include: requisite technical skillsets, knowledge of equipment capabilities, identifying inexpensive sources for materials, money, space, and time. A university MAKER space staffed by engineering students to assist researchers is one proposed solution to overcome many of these obstacles. This presentation investigates the unique capabilities the USDA-funded Openly Published Environmental Sensing (OPEnS) Lab affords researchers, within Oregon State and internationally, and the unique functions these types of initiatives support at the intersection of MAKER spaces, Open-Source academic research, and open-access dissemination.

Open life science research, open software and the open century

Directory of Open Access Journals (Sweden)

Youhua Chen

2015-05-01

Full Text Available At the age of knowledge explosion and mass scientific information, I highlighted the importance of conducting open science in life and medical researches through the extensive usage of open software and documents. The proposal of conducting open science is to reduce the limited repeatability of researches in life science. I outlined the essential steps for conducting open life science and the necessary standards for creating, reusing and reproducing open materials. Different Creative Commons licenses were presented and compared of their usage scope and restriction. As a conclusion, I argued that open materials should be widely adopted in doing life and medical researches.

A randomized comparison of intraoperative PerfecTemp and forced-air warming during open abdominal surgery.

Science.gov (United States)

Egan, Cameron; Bernstein, Ethan; Reddy, Desigen; Ali, Madi; Paul, James; Yang, Dongsheng; Sessler, Daniel I

2011-11-01

The PerfecTemp is an underbody resistive warming system that combines servocontrolled underbody warming with viscoelastic foam pressure relief. Clinical efficacy of the system has yet to be formally evaluated. We therefore tested the hypothesis that intraoperative distal esophageal (core) temperatures with the PerfecTemp (underbody resistive) warming system are noninferior to upper-body forced-air warming in patients undergoing major open abdominal surgery under general anesthesia. Adults scheduled for elective major open abdominal surgery (liver, pancreas, gynecological, and colorectal surgery) under general anesthesia were enrolled at 2 centers. Patients were randomly assigned to underbody resistive or forced-air warming. Resistive heating started when patients were transferred to the operating room table; forced-air warming started after patients were draped. The primary outcome was noninferiority of intraoperative time-weighted average core temperature, adjusted for baseline characteristics and using a buffer of 0.5°C. Thirty-six patients were randomly assigned to underbody resistive heating and 34 to forced-air warming. Baseline and surgical characteristics were generally similar. We had sufficient evidence (P=0.018) to conclude that underbody resistive warming is not worse than (i.e., noninferior to) upper-body forced-air warming in the time-weighted average intraoperative temperature, with a mean difference of -0.12°C [95% confidence interval (CI) -0.37 to 0.14]. Core temperatures at the end of surgery averaged 36.3°C [95% CI 36 to 36.5] in the resistive warming patients and 36.6°C [95% CI 36.4 to 36.8] in those assigned to forced-air warming for a mean difference of -0.34°C [95% CI -0.69 to 0.01]. Mean intraoperative time-weighted average core temperatures were no different, and significantly noninferior, with underbody resistive heating in comparison with upper-body forced-air warming. Underbody resistive heating may be an alternative to forced

Building a Quality Controlled Database of Meteorological Data from NASA Kennedy Space Center and the United States Air Force's Eastern Range

Science.gov (United States)

Brenton, James C.; Barbre. Robert E., Jr.; Decker, Ryan K.; Orcutt, John M.

2018-01-01

The National Aeronautics and Space Administration's (NASA) Marshall Space Flight Center (MSFC) Natural Environments Branch (EV44) has provided atmospheric databases and analysis in support of space vehicle design and day-of-launch operations for NASA and commercial launch vehicle programs launching from the NASA Kennedy Space Center (KSC), co-located on the United States Air Force's Eastern Range (ER) at the Cape Canaveral Air Force Station. The ER complex is one of the most heavily instrumented sites in the United States with over 31 towers measuring various atmospheric parameters on a continuous basis. An inherent challenge with large sets of data consists of ensuring erroneous data is removed from databases, and thus excluded from launch vehicle design analyses. EV44 has put forth great effort in developing quality control (QC) procedures for individual meteorological instruments, however no standard QC procedures for all databases currently exists resulting in QC databases that have inconsistencies in variables, methodologies, and periods of record. The goal of this activity is to use the previous efforts by EV44 to develop a standardized set of QC procedures from which to build meteorological databases from KSC and the ER, while maintaining open communication with end users from the launch community to develop ways to improve, adapt and grow the QC database. Details of the QC procedures will be described. As the rate of launches increases with additional launch vehicle programs, it is becoming more important that weather databases are continually updated and checked for data quality before use in launch vehicle design and certification analyses.

Persistence of Space Radiation-Induced Cytogenetic Damage in the Blood Lymphocytes of Astronauts and the Effects of Repeat Long Duration Space Missions

Science.gov (United States)

George, Kerry A.; Cucinotta, Francis A.

2009-01-01

The yield of chromosome damage in astronauts blood lymphocytes has been shown to increase after long duration space missions of a few months or more. This provides a useful in vivo measurement of space radiation induced damage that takes into account individual radiosensitivity and considers the influence of microgravity and other stress conditions. We present our latest follow-up analyses of chromosome damage in astronauts blood lymphocytes assessed by fluorescence in situ hybridization (FISH) chromosome painting and collected at various times, from directly after return from space to several years after flight. For most individuals the analysis of individual time-courses for translocations revealed a temporal decline of yields with different half-lives. Dose was derived from frequencies of chromosome exchanges using preflight calibration curves, and estimates derived from samples collected a few days after return to earth lie within the range expected from physical dosimetry. However, a temporal decline in yields may indicate complications with the use of stable aberrations for retrospective dose reconstruction, and the differences in the decay time may reflect individual variability in risk from space radiation exposure. Limited data on three individuals who have participated in repeat long duration space flights indicates a lack of correlation between time in space and translocation yields, and show a possible adaptive response to space radiation exposure.

What Attracts People to Visit Community Open Spaces? A Case Study of the Overseas Chinese Town Community in Shenzhen, China

Directory of Open Access Journals (Sweden)

Yiyong Chen

2016-06-01

Full Text Available A well-designed open space that encourages outdoor activity and social communication is a community asset that could potentially contribute to the health of local residents and social harmony of the community. Numerous factors may influence the use of each single space and may result in a variety of visitors. Compared with previous studies that focused on accessibility, this study highlights the relationship between the utilization and characteristics of community open spaces in China. The Overseas Chinese Town community in Shenzhen is regarded as an example. The association between the number of visitors and space characteristics is examined with multivariate regression models. Results show that large areas with accessible lawns, well-maintained footpaths, seats, commercial facilities, and water landscapes are important characteristics that could increase the use of community open spaces. However, adding green vegetation, sculptures, and landscape accessories in open spaces has limited effects on increasing the outdoor activities of residents. Thus, to increase the use of community open spaces, landscape designers should focus more on creating user-oriented spaces with facilities that encourage active use than on improving ornamental vegetation and accessories.

What Attracts People to Visit Community Open Spaces? A Case Study of the Overseas Chinese Town Community in Shenzhen, China

Science.gov (United States)

Chen, Yiyong; Liu, Tao; Xie, Xiaohuan; Marušić, Barbara Goličnik

2016-01-01

A well-designed open space that encourages outdoor activity and social communication is a community asset that could potentially contribute to the health of local residents and social harmony of the community. Numerous factors may influence the use of each single space and may result in a variety of visitors. Compared with previous studies that focused on accessibility, this study highlights the relationship between the utilization and characteristics of community open spaces in China. The Overseas Chinese Town community in Shenzhen is regarded as an example. The association between the number of visitors and space characteristics is examined with multivariate regression models. Results show that large areas with accessible lawns, well-maintained footpaths, seats, commercial facilities, and water landscapes are important characteristics that could increase the use of community open spaces. However, adding green vegetation, sculptures, and landscape accessories in open spaces has limited effects on increasing the outdoor activities of residents. Thus, to increase the use of community open spaces, landscape designers should focus more on creating user-oriented spaces with facilities that encourage active use than on improving ornamental vegetation and accessories. PMID:27367713

Best Management Practice, Fact Sheet 2. Sheet Flow to Open Space

OpenAIRE

Sample, David; Doumar, Lia

2013-01-01

This publication explains what sheet flow to open space is, where and how it is used, their limitations, routine and nonroutine maintenance, expected costs, and a glossary of terms. This fact sheet is one of a 15-part series on urban stormwater management practices.

Open control/display system for a telerobotics work station

Science.gov (United States)

Keslowitz, Saul

1987-01-01

A working Advanced Space Cockpit was developed that integrated advanced control and display devices into a state-of-the-art multimicroprocessor hardware configuration, using window graphics and running under an object-oriented, multitasking real-time operating system environment. This Open Control/Display System supports the idea that the operator should be able to interactively monitor, select, control, and display information about many payloads aboard the Space Station using sets of I/O devices with a single, software-reconfigurable workstation. This is done while maintaining system consistency, yet the system is completely open to accept new additions and advances in hardware and software. The Advanced Space Cockpit, linked to Grumman's Hybrid Computing Facility and Large Amplitude Space Simulator (LASS), was used to test the Open Control/Display System via full-scale simulation of the following tasks: telerobotic truss assembly, RCS and thermal bus servicing, CMG changeout, RMS constrained motion and space constructible radiator assembly, HPA coordinated control, and OMV docking and tumbling satellite retrieval. The proposed man-machine interface standard discussed has evolved through many iterations of the tasks, and is based on feedback from NASA and Air Force personnel who performed those tasks in the LASS.

Space Nuclear Thermal Propulsion (SNTP) Air Force facility

Science.gov (United States)

Beck, David F.

The Space Nuclear Thermal Propulsion (SNTP) Program is an initiative within the US Air Force to acquire and validate advanced technologies that could be used to sustain superior capabilities in the area or space nuclear propulsion. The SNTP Program has a specific objective of demonstrating the feasibility of the particle bed reactor (PBR) concept. The term PIPET refers to a project within the SNTP Program responsible for the design, development, construction, and operation of a test reactor facility, including all support systems, that is intended to resolve program technology issues and test goals. A nuclear test facility has been designed that meets SNTP Facility requirements. The design approach taken to meet SNTP requirements has resulted in a nuclear test facility that should encompass a wide range of nuclear thermal propulsion (NTP) test requirements that may be generated within other programs. The SNTP PIPET project is actively working with DOE and NASA to assess this possibility.

Public open space as the only urban space for walking: Sumatera Utara experience

Science.gov (United States)

Nasution, A. D.; Zahrah, W.; Ginting, Nurlisa

2018-03-01

One of successful public open space (POS) criteria is the proper pedestrian linkage. Furthermore, a good quality POS should pay attention to pedestrian activities. This will contribute to the physical and mental health of people and enhance their quality of life. The research means to investigate how POS accommodate the pedestrians. The study takes place in twenty small towns in Sumatra Utara province, Indonesia. The analysis is a descriptive, explorative study that collects data about physical elements of POS. The survey also uses a set of questionnaire to get information about the visitors walking tradition. The result of the study shows that most of the citizens approach and get to the POS by vehicle, both cars, and motorcycles. They use their private vehicles although the distance between their houses and the POS is less than one kilometer. There is no pedestrian linkage that connects the POS with the other part of urban space. However, the POS is active by various physical activities, such as walking, playing and exercising. These events occur both in pedestrian ways in the periphery, inside the POS, and in the other spots of the POS, such as grass field or multipurpose plaza. The visitors’ vehicle tradition relates to the whole urban space which is planned in a car-oriented way. Thus, the POS becomes the only space that people can walk and enjoy the environment.

Synergies in the space of control variables within the equilibrium-point hypothesis.

Science.gov (United States)

Ambike, S; Mattos, D; Zatsiorsky, V M; Latash, M L

2016-02-19

We use an approach rooted in the recent theory of synergies to analyze possible co-variation between two hypothetical control variables involved in finger force production based on the equilibrium-point (EP) hypothesis. These control variables are the referent coordinate (R) and apparent stiffness (C) of the finger. We tested a hypothesis that inter-trial co-variation in the {R; C} space during repeated, accurate force production trials stabilizes the fingertip force. This was expected to correspond to a relatively low amount of inter-trial variability affecting force and a high amount of variability keeping the force unchanged. We used the "inverse piano" apparatus to apply small and smooth positional perturbations to fingers during force production tasks. Across trials, R and C showed strong co-variation with the data points lying close to a hyperbolic curve. Hyperbolic regressions accounted for over 99% of the variance in the {R; C} space. Another analysis was conducted by randomizing the original {R; C} data sets and creating surrogate data sets that were then used to compute predicted force values. The surrogate sets always showed much higher force variance compared to the actual data, thus reinforcing the conclusion that finger force control was organized in the {R; C} space, as predicted by the EP hypothesis, and involved co-variation in that space stabilizing total force. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

An open-source job management framework for parameter-space exploration: OACIS

Science.gov (United States)

Murase, Y.; Uchitane, T.; Ito, N.

2017-11-01

We present an open-source software framework for parameter-space exporation, named OACIS, which is useful to manage vast amount of simulation jobs and results in a systematic way. Recent development of high-performance computers enabled us to explore parameter spaces comprehensively, however, in such cases, manual management of the workflow is practically impossible. OACIS is developed aiming at reducing the cost of these repetitive tasks when conducting simulations by automating job submissions and data management. In this article, an overview of OACIS as well as a getting started guide are presented.

Resistance to alveolar shape change limits range of force propagation in lung parenchyma.

Science.gov (United States)

Ma, Baoshun; Smith, Bradford J; Bates, Jason H T

2015-06-01

We have recently shown that if the lung parenchyma is modeled in 2 dimensions as a network of springs arranged in a pattern of repeating hexagonal cells, the distortional forces around a contracting airway propagate much further from the airway wall than classic continuum theory predicts. In the present study we tested the hypothesis that this occurs because of the negligible shear modulus of a hexagonal spring network. We simulated the narrowing of an airway embedded in a hexagonal network of elastic alveolar walls when the hexagonal cells of the network offered some resistance to a change in shape. We found that as the forces resisting shape change approach about 10% of the forces resisting length change of an individual spring the range of distortional force propagation in the spring network fell of rapidly as in an elastic continuum. We repeated these investigations in a 3-dimensional spring network composed of space-filling polyhedral cells and found similar results. This suggests that force propagation away from a point of local parenchymal distortion also falls off rapidly in real lung tissue. Copyright © 2015 Elsevier B.V. All rights reserved.

Managing for Multifunctionality in Urban Open Spaces: Approaches for Sustainable Development

Directory of Open Access Journals (Sweden)

Wenzheng Shi

Full Text Available ABSTRACT: Landscape management plays a key role in improving the quality of urban environments and enhancing the multifunctionality of green infrastructure. It works to guide the efficient and effective management of green spaces for sustainability and the well-being of users. However, while most researchers have emphasised spatial planning as a basis for developing green infrastructure to promote new strategic connections in urban green space, they have simultaneously ignored the impact of management. Against this background, this paper argues that if our towns and cities seek to maintain the well-being of citizens while also achieving sustainable environments, they must engage in effective landscape management to improve their green infrastructure. It is not enough to simply design or maintain parks and green spaces so as to keep up their physical condition; rather, green infrastructure work should be adapted to the understanding and implementation of managers, users and stakeholders in an integrated management process in order to provide more services for sustainable development. A selected study in Sheffield investigated the management planning required for sustainable development. It is beneficial to learn the experiences of management planning in Sheffield, a city which has rich management practices for green and open spaces. This study will analyse how management planning helps local authorities and managers to improve multifunctional green and open spaces in the context of sustainable development. As a result, the study also explores the framework of management planning with regard to the transferability of the existing practices in Sheffield. It also attempts to provide a primer for sustainability impact assessments in other cities with a considered knowledge exchange. KEYWORDS: Management planning, green infrastructure, multifunctionality, sustainability, knowledge exchange

Older Adults in Public Open Spaces: Age and Gender Segregation.

Science.gov (United States)

Noon, Rinat Ben; Ayalon, Liat

2018-01-18

There is a substantial body of literature on the importance of the environment in the lives of older adults. Nonetheless, to date, there has been limited research on everyday activities of urban older adults in public open spaces. The present study examined the activities of older adults in public open spaces in Israel with a specific focus on age and gender as potential variables of relevance. Using still photography, we systematically photographed four sessions in two different public outdoor settings attended by older Israelis. Still photographs were converted to narrative descriptions, and then coded, quantified, and compared using descriptive statistics. The majority (311, 97%) of older adults arrived alone to the public setting. Of these, 44% formed a social group of two or more people, whereas the remaining older adults stayed alone. When social interactions occurred, they were primarily gender homogenous (69%); women were more likely to integrate in spontaneous social conversations and men were more likely to participate in common games. Our findings call attention to the important role played by the outdoor environment as a venue for social activities among older adults. The findings further stress the high levels of aloneness experienced by older adults, which do not seem to be alleviated by the mere attendance of public spaces. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Compound list: haloperidol [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available haloperidol HPL 00036 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/haloperidol....Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/haloperidol....Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/haloperidol...archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/haloperidol.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: diltiazem [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available diltiazem DIL 00092 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/diltia...zem.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/diltia...zem.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/diltia...open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/diltiazem.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: tamoxifen [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available tamoxifen TMX 00054 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/tam...oxifen.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/tam...oxifen.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/tam...open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/tamoxifen.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: papaverine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available papaverine PAP 00098 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/papaverine.Human.in_vitro.Liver.zip ftp://ftp....biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/papa...verine.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/papa...ive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/papaverine.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: gemfibrozil [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available gemfibrozil GFZ 00031 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/gemfibrozil....Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/gemfibrozil....Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/gemfibrozil...archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/gemfibrozil.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: terbinafine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available terbinafine TBF 00123 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/terbinafine....Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/terbinafine....Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/terbinafine...archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/terbinafine.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: triazolam [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available triazolam TZM 00120 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/triazolam.Human.in_vitro.Liver.zip ftp://ftp.bi...osciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/triazolam....Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/triazolam...open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/triazolam.Rat.in_vivo.Liver.Repeat.zip ...

Sustainability: an Approach in Planning to Raise the Quality of Life Through Open Space Development

Directory of Open Access Journals (Sweden)

Sonal Y. Khobragade

2014-04-01

Full Text Available A presentation of the notion of sustainable development through the eye of a town planner, by elucidating how open space development would change the character of the city and augment towards harmony in the socio-environmental chords of sustainable development. It is an attempt to put forward awareness about the sustainability and environmental risk to ultimately reconcile ecological, social and economic factors of society. It is an attempt to reflect on socio-environmental dimension of the open space planning by addressing urban metamorphosis.

Using PHM to measure equipment usable life on the Air Force's next generation reusable space booster

Science.gov (United States)

Blasdel, A.

The U.S. Air Force procures many launch vehicles and launch vehicle services to place their satellites at their desired location in space. The equipment on-board these satellite and launch vehicle often suffer from premature failures that result in the total loss of the satellite or a shortened mission life sometimes requiring the purchase of a replacement satellite and launch vehicle. The Air Force uses its EELV to launch its high priority satellites. Due to a rise in the cost of purchasing a launch using the Air Force's EELV from 72M in 1997 to as high as 475M per launch today, the Air Force is working to replace the EELV with a reusable space booster (RSB). The RSB will be similar in design and operations to the recently cancelled NASA reusable space booster known as the Space Shuttle. If the Air Force uses the same process that procures the EELV and other launch vehicles and satellites, the RSB will also suffer from premature equipment failures thus putting the payloads at a similar high risk of mission failure. The RSB is expected to lower each launch cost by 50% compared to the EELV. The development of the RSB offers the Air Force an opportunity to use a new reliability paradigm that includes a prognostic and health management program and a condition-based maintenance program. These both require using intelligent, decision making self-prognostic equipment The prognostic and health management program and its condition-based maintenance program allows increases in RSB equipment usable life, lower logistics and maintenance costs, while increasing safety and mission assurance. The PHM removes many decisions from personnel that, in the past resulted in catastrophic failures and loss of life. Adding intelligent, decision-making self-prognostic equipment to the RSB will further decrease launch costs while decreasing risk and increasing safety and mission assurance.

Communication: Multiple atomistic force fields in a single enhanced sampling simulation

Energy Technology Data Exchange (ETDEWEB)

Hoang Viet, Man [Department of Physics, North Carolina State University, Raleigh, North Carolina 27695-8202 (United States); Derreumaux, Philippe, E-mail: philippe.derreumaux@ibpc.fr [Laboratoire de Biochimie Théorique, UPR 9080, CNRS, Université Denis Diderot, Sorbonne Paris Cité IBPC, 13 rue Pierre et Marie Curie, 75005 Paris (France); Institut Universitaire de France, 103 Bvd Saint-Germain, 75005 Paris (France); Nguyen, Phuong H., E-mail: phuong.nguyen@ibpc.fr [Laboratoire de Biochimie Théorique, UPR 9080, CNRS, Université Denis Diderot, Sorbonne Paris Cité IBPC, 13 rue Pierre et Marie Curie, 75005 Paris (France)

2015-07-14

The main concerns of biomolecular dynamics simulations are the convergence of the conformational sampling and the dependence of the results on the force fields. While the first issue can be addressed by employing enhanced sampling techniques such as simulated tempering or replica exchange molecular dynamics, repeating these simulations with different force fields is very time consuming. Here, we propose an automatic method that includes different force fields into a single advanced sampling simulation. Conformational sampling using three all-atom force fields is enhanced by simulated tempering and by formulating the weight parameters of the simulated tempering method in terms of the energy fluctuations, the system is able to perform random walk in both temperature and force field spaces. The method is first demonstrated on a 1D system and then validated by the folding of the 10-residue chignolin peptide in explicit water.

Compound list: fluphenazine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available fluphenazine FP 00037 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/flu...phenazine.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/flu...phenazine.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/flu...jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/fluphenazine.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: amitriptyline [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available amitriptyline AMT 00070 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/amit...riptyline.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/amit...riptyline.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/amit...edbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/amitriptyline.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: furosemide [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available furosemide FUR 00078 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/furose...mide.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/furose...mide.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/furose...ive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/furosemide.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: benzbromarone [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available benzbromarone BBr 00021 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/benz...bromarone.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/benz...bromarone.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/benz...edbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/benzbromarone.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: tolbutamide [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available tolbutamide TLB 00114 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/tolbutam...ide.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/tolbutam...ide.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/tolbutam...archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/tolbutamide.Rat.in_vivo.Liver.Repeat.zip ...

Evaluation of SPACE code for simulation of inadvertent opening of spray valve in Shin Kori unit 1

International Nuclear Information System (INIS)

Kim, Seyun; Youn, Bumsoo

2013-01-01

SPACE code is expected to be applied to the safety analysis for LOCA (Loss of Coolant Accident) and Non-LOCA scenarios. SPACE code solves two-fluid, three-field governing equations and programmed with C++ computer language using object-oriented concepts. To evaluate the analysis capability for the transient phenomena in the actual nuclear power plant, an inadvertent opening of spray valve in startup test phase of Shin Kori unit 1 was simulated with SPACE code. To evaluate the analysis capability for the transient phenomena in the actual nuclear power plant, an inadvertent opening of spray valve in startup test phase of Shin Kori unit 1 was simulated with SPACE code

Deep Space Exploration: Will We Be Ready? Infectious Diseases, Microgravity and Other Forces Affecting Health Pose Challenges for Humans Planning to Explore Space

Science.gov (United States)

LaRocco, Mark T.; Pierson, Duane L.

1999-01-01

In contemplating space travel beyond earth orbits, we humans face significant barriers and major challenges. Although researchers involved in several scientific subdisciplines, including space medicine and space life sciences, may provide insights to help overcome those barriers, their efforts are at an early stage of development, leaving open many questions of potentially major consequence.

The Conservation of the Landscape in the Perspective of a Public Open Spaces System in Recife

OpenAIRE

Carneiro, Ana Rita Sá; Duarte, Mirela; Marques, Eliábi A.

2009-01-01

This paper presents the relationship between the study of public open spaces and the urban landscape in Recife, according a systemic vision. This relationship is defined with the historical analysis of the natural ecosystems in the site landscape such as rivers, coast vegetation and mangrove, and the atlantic forest, which was occupied by the time. This method was chosen to understand the morphology of open spaces, its typology and which is preserved as natural and cultural heritage. Nowadays...

Compound list: acetamide [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available acetamide AAA 00169 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/acetam...ide.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/acetamide.Rat.in_vivo.Liver.Repeat.zip ...

COSMO: a decision-support system for the central open space, the Netherlands

NARCIS (Netherlands)

Harms, W.B.; Knaapen, J.P.; Roos-Klein-Lankhorst sic, J.

1995-01-01

To evaluate scenarios for nature restoration, a landscape ecological decision-support system has been developed, a knowledge-based system integrated in a geographical information system. The grid-based application in the Central Open Space of the Netherlands (the COSMO model) is presented here. Four

Twenty-three generations of mice bidirectionally selected for open-field thigmotaxis: selection response and repeated exposure to the open field.

Science.gov (United States)

Leppänen, Pia K; Ravaja, N; Ewalds-Kvist, S B M

2006-03-01

We examined: (a) the response to bidirectional selection for open-field (OF) thigmotaxis in mice for 23 generations and (b) the effects of repeated exposure (during 5 days) on different OF behaviors in the selectively bred high OF thigmotaxis (HOFT) and low OF thigmotaxis (LOFT) mice. A total of 2049 mice were used in the study. Prior to the testing in the selection experiment, the mice were exposed to the OF apparatus for approximately 2 min on each of 4 consecutive days. Thus, the selection was based on the scores registered on the 5th day after the four habituation periods. The HOFT mice were more thigmotactic than the LOFT mice in almost each generation. The HOFT mice also tended to rear less than the LOFT mice, which was explained by the inverse relationship between emotionality and exploratory tendencies. The lines did not generally differ in ambulation. Sex differences were found in thigmotaxis, ambulation, and rearing. In the repeated exposure experiment, the development of nine different OF behaviors across the 5 days of testing was addressed. Both lines ambulated, explored, and reared most on the 1st, 4th, and 5th days. Grooming and radial latency decreased and thigmotaxis increased linearly across the testing days. Line differences were found in ambulation, exploration, grooming, and rearing, while sex differences were manifested in ambulation and exploration. The line difference in thigmotaxis was evident only on the 5th day. Temporal changes were partially at variance with the general assumptions. OF thigmotaxis was found to be a powerful characteristic for producing two diverging lines of mice.

Compound list: acetaminophen [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available acetaminophen APAP 00001 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/acetam...inophen.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/acetam...inophen.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/i...cedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/acetaminophen.Rat.in_vivo.Liver.Repeat.zip ftp...://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/acetaminophen.Rat.in_vivo.Kidn

Compound list: ketoconazole [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available ketoconazole KC 00047 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/ketoco...nazole.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/ketoco...nazole.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/ketoco...jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/ketoconazole.Rat.in_vivo.Liver.Repeat.zip ftp://ftp....biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/ketoconazole.Rat.in_vivo.Kidney.Singl

Final Environmental Assessment for the California Space Center at Vandenberg Air Force Base, California

Science.gov (United States)

2010-06-02

rooted , mesophylic plant species that Chapter 3. Affected Environment Final Environmental Assessment - California Space Center, Vandenberg Air...Chapter 3. Affected Environment 3-12 Final Environmental Assessment - California Space Center, Vandenberg Air Force Base the root and debris zone of the...protruding objects, slippery soils or mud, and biological hazards including vegetation (i.e. poison oak and stinging nettle ), animals (i.e. insects

Compound list: chlorpheniramine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available chlorpheniramine CHL 00090 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/chlorpheni...ramine.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATE...ST/Rat/in_vivo/Liver/Single/chlorpheniramine.Rat.in_vivo.Liver.Single.zip ftp://f...tp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/chlorpheniramine.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: chloramphenicol [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available chloramphenicol CMP 00064 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/chlorampheni...col.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST...Rat/in_vivo/Liver/Single/chloramphenicol.Rat.in_vivo.Liver.Single.zip ftp://ftp.b...iosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/chloramphenicol.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: chlorpromazine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available chlorpromazine CPZ 00016 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Hum...an/in_vitro/chlorpromazine.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/R.../in_vivo/Liver/Single/chlorpromazine.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosc...iencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/chlorpromazine.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: clomipramine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available clomipramine CPM 00121 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/clomipramine....Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/clomipramine...vo/Liver/Single/clomipramine.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc....jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/clomipramine.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: promethazine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available promethazine PMZ 00110 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/promethazine....Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/promethazine...vo/Liver/Single/promethazine.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc....jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/promethazine.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: penicillamine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available penicillamine PEN 00099 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/penicillamine....Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/penicillamine..._vivo/Liver/Single/penicillamine.Rat.in_vivo.Liver.Single.zip ftp://ftp.bioscienc...edbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/penicillamine.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: glibenclamide [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available glibenclamide GBC 00042 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/glibenclam...ide.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/glibenclam..._vivo/Liver/Single/glibenclamide.Rat.in_vivo.Liver.Single.zip ftp://ftp.bioscienc...edbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/glibenclamide.Rat.in_vivo.Liver.Repeat.zip ...

Repeated forced swimming impairs prepulse inhibition and alters brain-derived neurotrophic factor and astroglial parameters in rats.

Science.gov (United States)

Borsoi, Milene; Antonio, Camila Boque; Müller, Liz Girardi; Viana, Alice Fialho; Hertzfeldt, Vivian; Lunardi, Paula Santana; Zanotto, Caroline; Nardin, Patrícia; Ravazzolo, Ana Paula; Rates, Stela Maris Kuze; Gonçalves, Carlos-Alberto

2015-01-01

Glutamate perturbations and altered neurotrophin levels have been strongly associated with the neurobiology of neuropsychiatric disorders. Environmental stress is a risk factor for mood disorders, disrupting glutamatergic activity in astrocytes in addition to cognitive behaviours. Despite the negative impact of stress-induced neuropsychiatric disorders on public health, the molecular mechanisms underlying the response of the brain to stress has yet to be fully elucidated. Exposure to repeated swimming has proven useful for evaluating the loss of cognitive function after pharmacological and behavioural interventions, but its effect on glutamate function has yet to be fully explored. In the present study, rats previously exposed to repeated forced swimming were evaluated using the novel object recognition test, object location test and prepulse inhibition (PPI) test. In addition, quantification of brain-derived neurotrophic factor (BDNF) mRNA expression and protein levels, glutamate uptake, glutathione, S100B, GluN1 subunit of N-methyl-D-aspartate receptor and calmodulin were evaluated in the frontal cortex and hippocampus after various swimming time points. We found that swimming stress selectively impaired PPI but did not affect memory recognition. Swimming stress altered the frontal cortical and hippocampal BDNF expression and the activity of hippocampal astrocytes by reducing hippocampal glutamate uptake and enhancing glutathione content in a time-dependent manner. In conclusion, these data support the assumption that astrocytes may regulate the activity of brain structures related to cognition in a manner that alters complex behaviours. Moreover, they provide new insight regarding the dynamics immediately after an aversive experience, such as after behavioural despair induction, and suggest that forced swimming can be employed to study altered glutamatergic activity and PPI disruption in rodents. Copyright © 2014. Published by Elsevier Inc.

Examining public open spaces by neighborhood-level walkability and deprivation.

Science.gov (United States)

Badland, Hannah M; Keam, Rosanna; Witten, Karen; Kearns, Robin

2010-11-01

Public open spaces (POS) are recognized as important to promote physical activity engagement. However, it is unclear how POS attributes, such as activities available, environmental quality, amenities present, and safety, are associated with neighborhood-level walkability and deprivation. Twelve neighborhoods were selected within 1 constituent city of Auckland, New Zealand based on higher (n = 6) or lower (n = 6) walkability characteristics. Neighborhoods were dichotomized as more (n = 7) or less (n = 5) socioeconomically deprived. POS (n = 69) were identified within these neighborhoods and audited using the New Zealand-Public Open Space Tool. Unpaired 1-way analysis of variance tests were applied to compare differences in attributes and overall score of POS by neighborhood walkability and deprivation. POS located in more walkable neighborhoods have significantly higher overall scores when compared with less walkable neighborhoods. Deprivation comparisons identified POS located in less deprived communities have better quality environments, but fewer activities and safety features present when compared with more deprived neighborhoods. A positive relationship existed between presence of POS attributes and neighborhood walkability, but the relationship between POS and neighborhood-level deprivation was less clear. Variation in neighborhood POS quality alone is unlikely to explain poorer health outcomes for residents in more deprived areas.

Frequency response of rectangular plates with free-edge openings and carlings subjected to point excitation force and enforced displacement at boundaries

Directory of Open Access Journals (Sweden)

Dae Seung Cho

2016-03-01

Full Text Available In this paper, a numerical procedure for the natural vibration analysis of plates with openings and carlings based on the assumed mode method is extended to assess their forced response. Firstly, natural response of plates with openings and carlings is calculated from the eigenvalue equation derived by using Lagrange's equation of motion. Secondly, the mode superposition method is applied to determine frequency response. Mindlin theory is adopted for plate modelling and the effect of openings is taken into account by subtracting their potential and kinetic energies from the corresponding plate energies. Natural and frequency response of plates with openings and carlings subjected to point excitation force and enforced acceleration at boundaries, respectively, is analysed by using developed in-house code. For the validation of the developed method and the code, extensive numerical results, related to plates with different opening shape, carlings and boundary conditions, are compared with numerical data from the relevant literature and with finite element solutions obtained by general finite element tool.

Compound list: nitrosodiethylamine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available nitrosodiethylamine DEN 00145 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATES...s/LATEST/Rat/in_vitro/nitrosodiethylamine.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tgg...ates/LATEST/Rat/in_vivo/Liver/Single/nitrosodiethylamine.Rat.in_vivo.Liver.Single....zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/nitrosodiethylamine.Rat.in_vivo.Liver.Repeat.zip ... ...T/Human/in_vitro/nitrosodiethylamine.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggate

Compound list: aspirin [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available aspirin ASA 00014 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/aspirin....Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/aspirin....Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/aspirin....Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/aspirin.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: doxorubicin [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available doxorubicin DOX 00149 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/...in_vitro/doxorubicin.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_...vitro/doxorubicin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/...Liver/Single/doxorubicin.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/...archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/doxorubicin.Rat.in_vivo.Liver.Repeat.zip ftp://ftp.bios

Compound list: ethanol [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available ethanol ETN 00137 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_v...itro/ethanol.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/et...hanol.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single.../ethanol.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/ethanol.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: adapin [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available adapin ADP 00039 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vi...tro/adapin.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/adap...in.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/ad...apin.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/adapin.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: danazol [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available danazol DNZ 00127 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_v...itro/danazol.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/da...nazol.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single.../danazol.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/danazol.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: allopurinol [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available allopurinol APL 00028 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/...in_vitro/allopurinol.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_...vitro/allopurinol.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/...Liver/Single/allopurinol.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/...archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/allopurinol.Rat.in_vivo.Liver.Repeat.zip ftp://ftp.bios

Compound list: ciprofloxacin [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available ciprofloxacin CPX 00050 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Huma...n/in_vitro/ciprofloxacin.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat.../in_vitro/ciprofloxacin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in..._vivo/Liver/Single/ciprofloxacin.Rat.in_vivo.Liver.Single.zip ftp://ftp.bioscienc...edbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/ciprofloxacin.Rat.in_vivo.Liver.Repeat.zip ftp:

Compound list: tacrine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available tacrine TAC 00060 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_v...itro/tacrine.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/ta...crine.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single.../tacrine.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/tacrine.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: monocrotaline [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available monocrotaline MCT 00058 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Huma...n/in_vitro/monocrotaline.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat.../in_vitro/monocrotaline.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in..._vivo/Liver/Single/monocrotaline.Rat.in_vivo.Liver.Single.zip ftp://ftp.bioscienc...edbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/monocrotaline.Rat.in_vivo.Liver.Repeat.zip ftp:

77 FR 5781 - Record of Decision for the Air Space Training Initiative Shaw Air Force Base, South Carolina...

Science.gov (United States)

2012-02-06

... DEPARTMENT OF DEFENSE Department of the Air Force Record of Decision for the Air Space Training Initiative Shaw Air Force Base, South Carolina Final Environmental Impact Statement ACTION: Notice of... signed the ROD for the Airspace Training Initiative Shaw Air Force Base, South Carolina Final...

Chronic exercise prevents repeated restraint stress-provoked enhancement of immobility in forced swimming test in ovariectomized mice.

Science.gov (United States)

Han, Tae-Kyung; Lee, Jang-Kyu; Leem, Yea-Hyun

2015-06-01

We assessed whether chronic treadmill exercise attenuated the depressive phenotype induced by restraint stress in ovariectomized mice (OVX). Immobility of OVX in the forced swimming test was comparable to that of sham mice (CON) regardless of the postoperative time. Immobility was also no difference between restrained mice (exposure to periodic restraint for 21 days; RST) and control mice (CON) on post-exposure 2nd and 9th day, but not 15th day. In contrast, the immobility of ovariectomized mice with repeated stress (OVX + RST) was profoundly enhanced compared to ovariectomized mice-alone (OVX), and this effect was reversed by chronic exercise (19 m/min, 60 min/day, 5 days/week for 8 weeks; OVX + RST + Ex) or fluoxetine administration (20 mg/kg, OVX + RST + Flu). In parallel with behavioral data, the immunoreactivity of Ki-67 and doublecortin (DCX) in OVX was significantly decreased by repeated stress. However, the reduced numbers of Ki-67- and DCX-positive cells in OVX + RST were restored in response to chronic exercise (OVX + RST + Ex) and fluoxetine (OVX + RST + Flu). In addition, the expression pattern of cAMP response element-binding protein (CREB) and calcium-calmodulin-dependent kinase IV (CaMKIV) was similar to that of the hippocampal proliferation and neurogenesis markers (Ki-67 and DCX, respectively). These results suggest that menopausal depression may be induced by an interaction between repeated stress and low hormone levels, rather than a deficit in ovarian secretion alone, which can be improved by chronic exercise.

Compound list: flutamide [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available flutamide FT 00044 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/flutam...ide.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/flutam...ide.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/flutam...pen-tggates/LATEST/Rat/in_vivo/Liver/Repeat/flutamide.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: acetamidofluorene [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available acetamidofluorene AAF 00144 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/acetam...idofluorene.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/acetam...ATEST/Rat/in_vivo/Liver/Single/acetamidofluorene.Rat.in_vivo.Liver.Single.zip ftp...://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/acetamidofluorene.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: diazepam [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available diazepam DZP 00023 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/diaz...epam.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/diaz...epam.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/diaz...-tggates/LATEST/Rat/in_vivo/Liver/Repeat/diazepam.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: coumarin [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available coumarin CMA 00027 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/coumari...n.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/coumari...n.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/coumari...-tggates/LATEST/Rat/in_vivo/Liver/Repeat/coumarin.Rat.in_vivo.Liver.Repeat.zip ...

Repeatability study of replicate crash tests: A signal analysis approach.

Science.gov (United States)

Seppi, Jeremy; Toczyski, Jacek; Crandall, Jeff R; Kerrigan, Jason

2017-10-03

To provide an objective basis on which to evaluate the repeatability of vehicle crash test methods, a recently developed signal analysis method was used to evaluate correlation of sensor time history data between replicate vehicle crash tests. The goal of this study was to evaluate the repeatability of rollover crash tests performed with the Dynamic Rollover Test System (DRoTS) relative to other vehicle crash test methods. Test data from DRoTS tests, deceleration rollover sled (DRS) tests, frontal crash tests, frontal offset crash tests, small overlap crash tests, small overlap impact (SOI) crash tests, and oblique crash tests were obtained from the literature and publicly available databases (the NHTSA vehicle database and the Insurance Institute for Highway Safety TechData) to examine crash test repeatability. Signal analysis of the DRoTS tests showed that force and deformation time histories had good to excellent repeatability, whereas vehicle kinematics showed only fair repeatability due to the vehicle mounting method for one pair of tests and slightly dissimilar mass properties (2.2%) in a second pair of tests. Relative to the DRS, the DRoTS tests showed very similar or higher levels of repeatability in nearly all vehicle kinematic data signals with the exception of global X' (road direction of travel) velocity and displacement due to the functionality of the DRoTS fixture. Based on the average overall scoring metric of the dominant acceleration, DRoTS was found to be as repeatable as all other crash tests analyzed. Vertical force measures showed good repeatability and were on par with frontal crash barrier forces. Dynamic deformation measures showed good to excellent repeatability as opposed to poor repeatability seen in SOI and oblique deformation measures. Using the signal analysis method as outlined in this article, the DRoTS was shown to have the same or better repeatability of crash test methods used in government regulatory and consumer evaluation test

Evaluation of force-torque displays for use with space station telerobotic activities

Science.gov (United States)

Hendrich, Robert C.; Bierschwale, John M.; Manahan, Meera K.; Stuart, Mark A.; Legendre, A. Jay

1992-01-01

Recent experiments which addressed Space Station remote manipulation tasks found that tactile force feedback (reflecting forces and torques encountered at the end-effector through the manipulator hand controller) does not improve performance significantly. Subjective response from astronaut and non-astronaut test subjects indicated that force information, provided visually, could be useful. No research exists which specifically investigates methods of presenting force-torque information visually. This experiment was designed to evaluate seven different visual force-torque displays which were found in an informal telephone survey. The displays were prototyped in the HyperCard programming environment. In a within-subjects experiment, 14 subjects nullified forces and torques presented statically, using response buttons located at the bottom of the screen. Dependent measures included questionnaire data, errors, and response time. Subjective data generally demonstrate that subjects rated variations of pseudo-perspective displays consistently better than bar graph and digital displays. Subjects commented that the bar graph and digital displays could be used, but were not compatible with using hand controllers. Quantitative data show similar trends to the subjective data, except that the bar graph and digital displays both provided good performance, perhaps do to the mapping of response buttons to display elements. Results indicate that for this set of displays, the pseudo-perspective displays generally represent a more intuitive format for presenting force-torque information.

Tidal wetland vegetation and ecotone profiles: The Rush Ranch Open Space Preserve

Science.gov (United States)

The Rush Ranch Open Space Preserve (Rush Ranch) is a component site of the San Francisco Bay National Estuarine Research Reserve (SF Bay NERR) that includes one of the largest undiked tidal wetlands in the San Francisco Estuary. The brackish tidal wetlands grade into transitional vegetation and unde...

Compound list: methyltestosterone [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available methyltestosterone MTS 00041 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/methyltes...LATEST/Rat/in_vitro/methyltestosterone.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggate...s/LATEST/Rat/in_vivo/Liver/Single/methyltestosterone.Rat.in_vivo.Liver.Single.zip... ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/methyltestosterone.Rat.in_v...ivo.Liver.Repeat.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/methyltest

Compound list: thioacetamide [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available thioacetamide TAA 00017 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/thioacetamide.Human.in_vitro.Liver.zip ftp:...//ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/thioacetam..._vivo/Liver/Single/thioacetamide.Rat.in_vivo.Liver.Single.zip ftp://ftp.bioscienc...edbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/thioacetamide.Rat.in_vivo.Liver.Repeat.zip ftp:...//ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/thioacetamide.Rat.in_vivo.Kidne

Compound list: phenacetin [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available phenacetin PCT 00138 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/i...n_vitro/phenacetin.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vi...tro/phenacetin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liv...er/Single/phenacetin.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/arch...ive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/phenacetin.Rat.in_vivo.Liver.Repeat.zip ftp://ftp.bioscienc

Compound list: imipramine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available imipramine IMI 00069 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/i...n_vitro/imipramine.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vi...tro/imipramine.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liv...er/Single/imipramine.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/arch...ive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/imipramine.Rat.in_vivo.Liver.Repeat.zip ftp://ftp.bioscienc

Compound list: ethinylestradiol [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available ethinylestradiol EE 00055 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Hu...man/in_vitro/ethinylestradiol.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATES...T/Rat/in_vitro/ethinylestradiol.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATES...T/Rat/in_vivo/Liver/Single/ethinylestradiol.Rat.in_vivo.Liver.Single.zip ftp://ft...p.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/ethinylestradiol.Rat.in_vivo.Liver.Repeat.zip ftp:

Compound list: carboplatin [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available carboplatin CBP 00133 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in..._vitro/carboplatin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo.../Liver/Single/carboplatin.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATES...T/Rat/in_vivo/Liver/Repeat/carboplatin.Rat.in_vivo.Liver.Repeat.zip ftp://ftp.bio...sciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/carboplatin.Rat.in_vivo.Kidney.Single.zip ftp:

Compound list: cephalothin [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available cephalothin CLT 00141 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in..._vitro/cephalothin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo.../Liver/Single/cephalothin.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATES...T/Rat/in_vivo/Liver/Repeat/cephalothin.Rat.in_vivo.Liver.Repeat.zip ftp://ftp.bio...sciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/cephalothin.Rat.in_vivo.Kidney.Single.zip ftp:

Compound list: omeprazole [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available omeprazole OPZ 00012 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/i...n_vitro/omeprazole.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vi...tro/omeprazole.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liv...er/Single/omeprazole.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/arch...ive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/omeprazole.Rat.in_vivo.Liver.Repeat.zip ftp://ftp.bioscienc

Compound list: triamterene [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available triamterene TRI 00101 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in..._vitro/triamterene.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo.../Liver/Single/triamterene.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATES...T/Rat/in_vivo/Liver/Repeat/triamterene.Rat.in_vivo.Liver.Repeat.zip ftp://ftp.bio...sciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/triamterene.Rat.in_vivo.Kidney.Single.zip ftp:

Compound list: nitrofurantoin [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available nitrofurantoin NFT 00020 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Hum...an/in_vitro/nitrofurantoin.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/R...at/in_vitro/nitrofurantoin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat.../in_vivo/Liver/Single/nitrofurantoin.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosc...iencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/nitrofurantoin.Rat.in_vivo.Liver.Repeat.zip ftp:

Compound list: acetazolamide [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available acetazolamide ACZ 00108 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/acetazolam...ide.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/acetazolam..._vivo/Liver/Single/acetazolamide.Rat.in_vivo.Liver.Single.zip ftp://ftp.bioscienc...edbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/acetazolamide.Rat.in_vivo.Liver.Repeat.zip ftp:...//ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/acetazolamide.Rat.in_vivo.Kidne

An Analysis of Shelf Space Allocation at the Wright-Patterson Air Force Base Commissary.

Science.gov (United States)

1987-09-01

Company performed a major shelf space allocation study involving 59 of their stores. The study involved planning and executing a shelf by shelf reset...Betty Crocker Chocolate .a9 2 Betty CrocKer Yellow .93 3 Betty Crocker Devils Food .92 4 Betty Crocker Choc . Choc . Chip .94 5 Betty Crocker German...Headquarters Air Force Commissary Services. ACOS Executive Summary. 28 January 19d6. 12. deadquarters Air Force Commissary Services. Store _Layout

Space closing versus space opening for bilateral missing upper laterals - aesthetic judgments of laypeople: a web-based survey.

Science.gov (United States)

Qadri, Salim; Parkin, Nicola A; Benson, Philip E

2016-06-01

To investigate the opinions of laypeople regarding the aesthetic outcome of treating patients with developmental absence of both maxillary lateral incisors using either orthodontic space closure (OSC) or space opening and prosthetic replacement (PR). Cross sectional, web-based survey. A panel of five orthodontists and five restorative dentists examined post-treatment intra-oral images of 21 patients with developmental absence of both upper lateral incisors. A consensus view was obtained about the 10 most attractive images (5 OSC; 5 PR). The 10 selected images were used in a web-based survey involving staff and students at the University of Sheffield. In the first section, the participants were asked to evaluate the attractiveness of the 10 randomly arranged single images using a 5-point Likert scale. In the second section, an image of OSC was paired with an image of PR according to their attractiveness ranking by the clinician panel, and the participants were asked to indicate which of the two images they preferred. The survey received 959 completed responses with 9590 judgements. The images of OSC were perceived to be more attractive (mean rating 3·34 out of 5; SD 0·56) compared with the images of PR (mean rating 3·14 out of 5; SD 0·58) (mean diff 0·21; P Space closing was perceived to be more attractive than space opening by lay people. The findings have implications for advising patients about the best aesthetic outcome when both maxillary lateral incisors are missing.

Antidepressant-like effect of oleanolic acid in mice exposed to the repeated forced swimming test.

Science.gov (United States)

Yi, Li-Tao; Li, Jing; Liu, Qing; Geng, Di; Zhou, Ya-Fei; Ke, Xiao-Qing; Chen, Huan; Weng, Lian-Jin

2013-05-01

The study aimed to explore the antidepressant-like effect of oleanolic acid and its possible mechanism related to the monoaminergic system and neurotrophin in mice exposed to the repeated forced swimming test (FST). Both the duration and the latency of immobility affected by oleanolic acid (10, 20 and 40 mg/kg) were evaluated in the FST repeated at intervals on days 1, 7 and 14, followed by neurochemical and brain-derived neurotrophic factor (BDNF) analyses in the mouse brain regions of frontal cortex and whole hippocampus. A repeated analysis of variance (ANOVA) indicated that over retesting the immobility time increased, whereas latency to immobility tended to decrease. Minute-by-minute analysis showed that immobility time also increased during the 4-min course of the test. In addition, post-hoc Dunnett's test demonstrated that sub-chronic and chronic, but not acute, oleanolic acid treatment reduced the immobility time (sub-chronic: 20 mg/kg, 43.5%; chronic: 10 mg/kg, 19.3%; 20 mg/kg, 31.8%) and increased the latency to immobility (sub-chronic: 10 mg/kg, 60.6%; 20 mg/kg, 80.1%; chronic: 10 mg/kg, 121.8%; 20 mg/kg, 140.8%; 40 mg/kg, 80.0%). Furthermore, chronic administration of oleanolic acid significantly increased serotonin (5-HT) levels (frontal cortex: 44.5%, 41.9%, 27.5% for 10, 20, 40 mg/kg; hippocampus: 57.2%, 80.9% for 10, 20 mg/kg), decreased 5-hydroxyindoleacetic acid (5-HIAA)/5-HT ratio (frontal cortex: 31.6%, 30.1%, 23.5%; hippocampus: 40.6%, 47.7%, 29.2% for 10, 20, 40 mg/kg) and elevated norepinephrine (NE) levels (hippocampus: 20 mg/kg, 45.4%) but did not alter dopamine (DA) levels. Moreover, BDNF levels in the two brain regions were also elevated by chronic oleanolic acid treatment (frontal cortex: 20 mg/kg, 67.2%; hippocampus: 10 mg/kg, 36.4%; 20 mg/kg, 55.1%). Taken together, these findings imply that functions of 5-HT, NE and BDNF may be involved in the antidepressant-like effect of oleanolic acid.

Open Space Office and it's Influence on Satisfaction of Workers

OpenAIRE

Novotná, Marta

2015-01-01

This bachelor thesis focuses on open space office in relation to satisfaction with employment. It focuses on research of factors of this specific working environment and tries to check hypothesis talking about negative impact on overal satsfacton with job. Through the research conducted within one company this bachelor thesis present evaluation of factos of working environment and show overal impact of these factors on satisfaction with job. This bachelor thesis finds out that noise and disco...

Opening new institutional spaces for grappling with uncertainty: A constructivist perspective

International Nuclear Information System (INIS)

Duncan, Ronlyn

2013-01-01

In the context of an increasing reliance on predictive computer simulation models to calculate potential project impacts, it has become common practice in impact assessment (IA) to call on proponents to disclose uncertainties in assumptions and conclusions assembled in support of a development project. Understandably, it is assumed that such disclosures lead to greater scrutiny and better policy decisions. This paper questions this assumption. Drawing on constructivist theories of knowledge and an analysis of the role of narratives in managing uncertainty, I argue that the disclosure of uncertainty can obscure as much as it reveals about the impacts of a development project. It is proposed that the opening up of institutional spaces that can facilitate the negotiation and deliberation of foundational assumptions and parameters that feed into predictive models could engender greater legitimacy and credibility for IA outcomes. - Highlights: ► A reliance on supposedly objective disclosure is unreliable in the predictive model context in which IA is now embedded. ► A reliance on disclosure runs the risk of reductionism and leaves unexamined the social-interactive aspects of uncertainty. ► Opening new institutional spaces could facilitate deliberation on foundational predictive model assumptions.

Compound list: caffeine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available caffeine CAF 00097 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/caffeine....Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/caffeine....Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/caffeine...-tggates/LATEST/Rat/in_vivo/Liver/Repeat/caffeine.Rat.in_vivo.Liver.Repeat.zip ftp://ftp.biosciencedbc.jp/ar...chive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/caffeine.Rat.in_vivo.Kidney.Single.zip ftp://ftp.bioscie

Compound list: bucetin [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available bucetin BCT 00139 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_v...itro/bucetin.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/bu...cetin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single.../bucetin.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/archive/open-tgg...ates/LATEST/Rat/in_vivo/Liver/Repeat/bucetin.Rat.in_vivo.Liver.Repeat.zip ftp://ftp.biosciencedbc.jp/archive

Compound list: cisplatin [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available cisplatin CSP 00132 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_v...itro/cisplatin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liv...er/Single/cisplatin.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/...in_vivo/Liver/Repeat/cisplatin.Rat.in_vivo.Liver.Repeat.zip ftp://ftp.bioscienced...bc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/cisplatin.Rat.in_vivo.Kidney.Single.zip ftp://ft

Compound list: lomustine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available lomustine LS 00049 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/lomustine....Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/lomustine....Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/lomustine...pen-tggates/LATEST/Rat/in_vivo/Liver/Repeat/lomustine.Rat.in_vivo.Liver.Repeat.zip ftp://ftp.biosciencedbc.j...p/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/lomustine.Rat.in_vivo.Kidney.Single.zip ftp://ftp.bi

Compound list: ethionine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available ethionine ET 00013 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/ethionine....Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/ethionine....Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/ethionine...pen-tggates/LATEST/Rat/in_vivo/Liver/Repeat/ethionine.Rat.in_vivo.Liver.Repeat.zip ftp://ftp.biosciencedbc.j...p/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/ethionine.Rat.in_vivo.Kidney.Single.zip ftp://ftp.bi

Long-Term Safety of Repeated Blood-Brain Barrier Opening via Focused Ultrasound with Microbubbles in Non-Human Primates Performing a Cognitive Task.

Science.gov (United States)

Downs, Matthew E; Buch, Amanda; Sierra, Carlos; Karakatsani, Maria Eleni; Teichert, Tobias; Chen, Shangshang; Konofagou, Elisa E; Ferrera, Vincent P

2015-01-01

Focused Ultrasound (FUS) coupled with intravenous administration of microbubbles (MB) is a non-invasive technique that has been shown to reliably open (increase the permeability of) the blood-brain barrier (BBB) in multiple in vivo models including non-human primates (NHP). This procedure has shown promise for clinical and basic science applications, yet the safety and potential neurological effects of long term application in NHP requires further investigation under parameters shown to be efficacious in that species (500 kHz, 200-400 kPa, 4-5 μm MB, 2 minute sonication). In this study, we repeatedly opened the BBB in the caudate and putamen regions of the basal ganglia of 4 NHP using FUS with systemically-administered MB over 4-20 months. We assessed the safety of the FUS with MB procedure using MRI to detect edema or hemorrhaging in the brain. Contrast enhanced T1-weighted MRI sequences showed a 98% success rate for openings in the targeted regions. T2-weighted and SWI sequences indicated a lack edema in the majority of the cases. We investigated potential neurological effects of the FUS with MB procedure through quantitative cognitive testing of' visual, cognitive, motivational, and motor function using a random dot motion task with reward magnitude bias presented on a touchpanel display. Reaction times during the task significantly increased on the day of the FUS with MB procedure. This increase returned to baseline within 4-5 days after the procedure. Visual motion discrimination thresholds were unaffected. Our results indicate FUS with MB can be a safe method for repeated opening of the BBB at the basal ganglia in NHP for up to 20 months without any long-term negative physiological or neurological effects with the parameters used.

Scientific competency questions as the basis for semantically enriched open pharmacological space development

DEFF Research Database (Denmark)

Azzaoui, Kamal; Jacoby, Edgar; Senger, Stefan

2013-01-01

Molecular information systems play an important part in modern data-driven drug discovery. They do not only support decision making but also enable new discoveries via association and inference. In this review, we outline the scientific requirements identified by the Innovative Medicines Initiative...... (IMI) Open PHACTS consortium for the design of an open pharmacological space (OPS) information system. The focus of this work is the integration of compound–target–pathway–disease/phenotype data for public and industrial drug discovery research. Typical scientific competency questions provided...

Compound list: ajmaline [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available ajmaline AJM 00118 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/ajmaline....Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/ajmaline....Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/ajmaline.Rat.in_vivo.Liver.Single.zip ftp://ftp.bi...-tggates/LATEST/Rat/in_vivo/Liver/Repeat/ajmaline.Rat.in_vivo.Liver.Repeat.zip ...

Comparisons of an open-ended vs. forced-choice 'mind reading' task: implications for measuring perspective-taking and emotion recognition.

Directory of Open Access Journals (Sweden)

Tracy G Cassels

Full Text Available Perspective-taking and emotion recognition are essential for successful social development and have been the focus of developmental research for many years. Although the two abilities often overlap, they are distinct and our understanding of these abilities critically rests upon the efficacy of existing measures. Lessons from the literature differentiating recall versus recognition memory tasks led us to hypothesize that an open-ended emotion recognition measure would be less reliant on compensatory strategies and hence a more specific measure of emotion recognition abilities than a forced-choice task. To this end, we compared an open-ended version of the Reading the Mind in the Eyes Task with the original forced-choice version in two studies: 118 typically-developing 4- to 8-year-olds (Study 1 and 139 5- to 12-year-olds; 85 typically-developing and 54 with learning disorders (Study 2. We found that the open-ended version of the task was a better predictor of empathy and more reliably discriminated typically-developing children from those with learning disorders. As a whole, the results suggest that the open-ended version is a more sensitive measure of emotion recognition specifically.

The Effectiveness of Building Permit Regulation for Green Open Space at Housing Estates: Case Study of Kendal Regency, Central Java, Indonesia

Science.gov (United States)

Yulianti, Wiwik; Hadi, Sudharto P.

2018-02-01

Increasing demand for settlements steamed by population growth declines the quality of the environment specifically at urban area. The existing spatial planning could not able to prevent the change of land use for settlement and other infrastructures. The Act no. 26 of 2007 on spatial planning stipulates that green open space must reach 30% of the total area, consisting of 20% public open space and 10% private open space. The existing condition of urban area at Kendal Regency reach 245,6 million m2 with 88.145,5 m2 green open space or 0,036% out of total area. An effort to increase green open space in urban areas taken by the Government of Kendal Regency is by promulgating a local regulation stipulating that each housing developer request a building permit is obliged to provide a green open space at least 10 percent of the total housing area. This paper reviews the effectiveness of building permit regulation, the problems encountered and the concept proposed to make the local regulation work. The area of sample taken is three urban districts out of five urban districts, the resource persons chosen are those from relevant offices (Dinas) involved at the implementation of the local regulation. The data collection techniques employed are the Analytical Hierarchy Process (AHP), Geographic Information System (GIS) technology, social observation and informal interview. The data gathered will be analyzed quantitatively and qualitatively.

The Effectiveness of Building Permit Regulation for Green Open Space at Housing Estates: Case Study of Kendal Regency, Central Java, Indonesia

Directory of Open Access Journals (Sweden)

Yulianti Wiwik

2018-01-01

Full Text Available Increasing demand for settlements steamed by population growth declines the quality of the environment specifically at urban area. The existing spatial planning could not able to prevent the change of land use for settlement and other infrastructures. The Act no. 26 of 2007 on spatial planning stipulates that green open space must reach 30% of the total area, consisting of 20% public open space and 10% private open space. The existing condition of urban area at Kendal Regency reach 245,6 million m2 with 88.145,5 m2 green open space or 0,036% out of total area. An effort to increase green open space in urban areas taken by the Government of Kendal Regency is by promulgating a local regulation stipulating that each housing developer request a building permit is obliged to provide a green open space at least 10 percent of the total housing area. This paper reviews the effectiveness of building permit regulation, the problems encountered and the concept proposed to make the local regulation work. The area of sample taken is three urban districts out of five urban districts, the resource persons chosen are those from relevant offices (Dinas involved at the implementation of the local regulation. The data collection techniques employed are the Analytical Hierarchy Process (AHP, Geographic Information System (GIS technology, social observation and informal interview. The data gathered will be analyzed quantitatively and qualitatively.

Technical note: use of belt grill cookery and slice shear force for assessment of pork longissimus tenderness.

Science.gov (United States)

Shackelford, S D; Wheeler, T L; Koohmaraie, M

2004-01-01

The present experiments were conducted to determine whether improved beef longissimus shear force methodology could be used to assess pork longissimus tenderness. Specifically, three experiments were conducted to: 1) determine the effect of belt grill (BG) cookery on repeatability of pork longissimus Warner-Bratzler shear force (WBSF), 2) compare the correlation of WBSF and slice shear force (SSF) with trained sensory panel tenderness ratings, and 3) estimate the repeatability of pork longissimus SSF for chops cooked with a BG. In Exp. 1 and 2, the longissimus was removed from the left side of each carcass (Exp. 1, n = 25; Exp. 2, n = 23) at 1 d postmortem and immediately frozen to maximize variation in tenderness. In Exp. 1, chops were cooked with either open-hearth electric broilers (OH) or BG, and WBSF was measured. Percentage of cooking loss was lower (P cooked with a BG (23.2%; SD = 1.7%) vs. OH (27.6%; SD = 3.0%). Estimates of the repeatability of WBSF were similar for chops cooked with OH (0.61) and BG (0.59). Although significant (P cooking methods accounted for less than 5% of the total variation in WBSF. In Exp. 2, the correlation of SSF (r = -0.72; P cooked with BG, and SSF was determined. The repeatability of SSF was 0.90, which is comparable to repeatability estimates for beef and lamb. Use of BG cookery and SSF could facilitate the collection of accurate pork longissimus tenderness data. Time and labor savings associated with BG cookery and the SSF technique should help to decrease research costs.

Grassland communities of urban open spaces in Bloemfontein, Free State, South Africa

Directory of Open Access Journals (Sweden)

Mamokete N.V. Dingaan

2013-02-01

Full Text Available Natural vegetation in urban environments is greatly impacted by human activities and it is in constant threat of degradation and destruction as a result of urbanisation. This vegetation, although fragmented, serves an important ecological function and needs to be properly managed and conserved. Studies on urban vegetation are lacking in South Africa, with only a handful having been carried out since the end of the last century. This study was initiated to identify, classify and describe the grassland communities of the urban open spaces in Bloemfontein. Relevés were compiled in 61 sample plots, where species present and habitat information were recorded. Care was taken to restrict sample plots to vegetation in pristine condition, wherever possible, and severely degraded stands were avoided. A two-way indicator species analysis (TWINSPAN classification, refined by Braun-Blanquet procedures, revealed two distinct major communities, seven communities and four sub-communities. Both detrended and canonical correspondence analyses indicated the vegetation units to be associated with soil texture and pH, although biotic factors such as overgrazing, burning and mowing also influence the composition of the vegetation. The proper management and conservation of urban open spaces requires in-depth knowledge of the spatial distribution, floristic, structural and functional compositions within the major vegetation types in this environment. The present study further contributed towards formulating ways for the proper management, utilisation and functioning of the open spaces within the Bloemfontein area.Conservation implications: The Grassland Biome of South Africa is poorly conserved, mainly because of its status as an agricultural hub of the country. The preservation of natural and semi-natural forms of urban vegetation is important because such vegetation, although often disturbed and degraded, could form dispersal corridors between peri-urban and rural

Economic analysis of open space box model utilization in spacecraft

Science.gov (United States)

Mohammad, Atif F.; Straub, Jeremy

2015-05-01

It is a known fact that the amount of data about space that is stored is getting larger on an everyday basis. However, the utilization of Big Data and related tools to perform ETL (Extract, Transform and Load) applications will soon be pervasive in the space sciences. We have entered in a crucial time where using Big Data can be the difference (for terrestrial applications) between organizations underperforming and outperforming their peers. The same is true for NASA and other space agencies, as well as for individual missions and the highly-competitive process of mission data analysis and publication. In most industries, conventional opponents and new candidates alike will influence data-driven approaches to revolutionize and capture the value of Big Data archives. The Open Space Box Model is poised to take the proverbial "giant leap", as it provides autonomic data processing and communications for spacecraft. We can find economic value generated from such use of data processing in our earthly organizations in every sector, such as healthcare, retail. We also can easily find retailers, performing research on Big Data, by utilizing sensors driven embedded data in products within their stores and warehouses to determine how these products are actually used in the real world.

Report by the International Space Station (ISS) Management and Cost Evaluation (IMCE) Task Force

Science.gov (United States)

Young, A. Thomas; Kellogg, Yvonne (Technical Monitor)

2001-01-01

The International Space Station (ISS) Management and Cost Evaluation Task Force (IMCE) was chartered to conduct an independent external review and assessment of the ISS cost, budget, and management. In addition, the Task Force was asked to provide recommendations that could provide maximum benefit to the U.S. taxpayers and the International Partners within the President's budget request. The Task Force has made the following principal findings: (1) The ISS Program's technical achievements to date, as represented by on-orbit capability, are extraordinary; (2) The Existing ISS Program Plan for executing the FY 02-06 budget is not credible; (3) The existing deficiencies in management structure, institutional culture, cost estimating, and program control must be acknowledged and corrected for the Program to move forward in a credible fashion; (4) Additional budget flexibility, from within the Office of Space Flight (OSF) must be provided for a credible core complete program; (5) The research support program is proceeding assuming the budget that was in place before the FY02 budget runout reduction of $1B; (6) There are opportunities to maximize research on the core station program with modest cost impact; (7) The U.S. Core Complete configuration (three person crew) as an end-state will not achieve the unique research potential of the ISS; (8) The cost estimates for the U.S.-funded enhancement options (e.g., permanent seven person crew) are not sufficiently developed to assess credibility. After these findings, the Task Force has formulated several primary recommendations which are published here and include: (1) Major changes must be made in how the ISS program is managed; (2) Additional cost reductions are required within the baseline program; (3) Additional funds must be identified and applied from the Human Space Flight budget; (4) A clearly defined program with a credible end-state, agreed to by all stakeholders, must be developed and implemented.

Evaluation of speech transmission in open public spaces affected by combined noises.

Science.gov (United States)

Lee, Pyoung Jik; Jeon, Jin Yong

2011-07-01

In the present study, the effects of interference from combined noises on speech transmission were investigated in a simulated open public space. Sound fields for dominant noises were predicted using a typical urban square model surrounded by buildings. Then road traffic noise and two types of construction noises, corresponding to stationary and impulsive noises, were selected as background noises. Listening tests were performed on a group of adults, and the quality of speech transmission was evaluated using listening difficulty as well as intelligibility scores. During the listening tests, two factors that affect speech transmission performance were considered: (1) temporal characteristics of construction noise (stationary or impulsive) and (2) the levels of the construction and road traffic noises. The results indicated that word intelligibility scores and listening difficulty ratings were affected by the temporal characteristics of construction noise due to fluctuations in the background noise level. It was also observed that listening difficulty is unable to describe the speech transmission in noisy open public spaces showing larger variation than did word intelligibility scores. © 2011 Acoustical Society of America

DAYLIGHTING PERFORMANCE OF HORIZONTAL LIGHT PIPE BRANCHING ON OPEN PLAN OFFICE SPACE

Directory of Open Access Journals (Sweden)

Feny ELSIANA

2015-12-01

Full Text Available For daylighting purpose, office buildings should have a shallow plan and increase the ratio of surface to building’s volume. However, intensive use of air-conditioning drives office building’s plan to be deep with a minimum surface to volume ratio. This leads to the presence of areas that have insufficient daylight level at the work plane. Considering limitations of some daylighting methods in distributing daylight to these areas, Horizontal Light Pipe (HLP was selected. The aim of this research was to evaluate and explain the effect of HLP branching on daylight quantity and distribution inside open plan office space. Experimental with simulation as a tool was used as the research method. HLP branching’s uniformity ratio, illuminance and Daylight Factor were compared with unbranching HLP, simultaneously with daylighting standards. Results showed that office space with HLP-L branching had higher daylight level than HLP-T branching, 296 lux and 295 lux, HLP-L and HLP-T, respectively. However, HLP-T branching distributed daylight more evenly than HLP-L branching, with uniformity ratio as 1.49:1 and 1.50:1, HLP-T and HLP-L, respectively. Both of them met the illuminance target value and uniformity at work plane. Light’s deflection and improvement amount of opening distribution decreased average illuminance and Daylight Factor up to 3.59%. Those also decreased uniformity of daylight inside the space.

m-Trifluoromethyl-diphenyl Diselenide Regulates Prefrontal Cortical MOR and KOR Protein Levels and Abolishes the Phenotype Induced by Repeated Forced Swim Stress in Mice.

Science.gov (United States)

Rosa, Suzan Gonçalves; Pesarico, Ana Paula; Martini, Franciele; Nogueira, Cristina Wayne

2018-04-05

The present study aimed to investigate the m-trifluoromethyl-diphenyl diselenide [(m-CF 3 -PhSe) 2 ] effects on prefrontal cortical MOR and KOR protein levels and phenotype induced by repeated forced swim stress (FSS) in mice. Adult Swiss mice were subjected to repeated FSS sessions, and after that, they performed the spontaneous locomotor/exploratory activity, tail suspension, and splash tests. (m-CF 3 -PhSe) 2 (0.1 to 5 mg/kg) was administered to mice 30 min before the first FSS session and 30 min before the subsequent repeated FSS. (m-CF 3 -PhSe) 2 abolished the phenotype induced by repeated FSS in mice. In addition, a single FSS session increased μ but reduced δ-opioid receptor contents, without changing the κ content. Mice subjected to repeated FSS had an increase in the μ content when compared to those of naïve group or subjected to single FSS. Repeated FSS induced an increase of δ-opioid receptor content compared to those mice subjected to single FSS. However, the δ-opioid receptor contents were lower than those found in the naïve group. The mice subjected to repeated FSS showed an increase in the κ-opioid receptor content when compared to that of the naïve mice. (m-CF 3 -PhSe) 2 regulated the protein contents of μ and κ receptors in mice subjected to repeated FSS. These findings demonstrate that (m-CF 3 -PhSe) 2 was effective to abolish the phenotype induced by FSS, which was accompanied by changes in the contents of cortical μ- and κ-opioid receptors.

Promoting Productive Urban Green Open Space Towards Food Security: Case Study Taman Sari, Bandung

Science.gov (United States)

Ridwan, M.; Sinatra, Fran; Natalivan, Petrus

2017-10-01

The common trend of urban population has been growing significantly in Indonesia for decades, are affected by urban green space conversion. Generally, this area is utilized for urban infrastructures and residences. Furthermore, urban area has grown uncontrollably that could enhance the phenomenon of urban sprawl. The conversion of green urban area and agricultural area will significantly decrease urban food security and quality of urban environment. This problem becomes a serious issue for urban sustainability. Bandung is a city with dense population where there are many poor inhabitants. Families living in poverty are subjected to food insecurity caused by the rise of food prices. Based on the urgency of urban food security and urban environment quality the local government has to achieve comprehensive solutions. This research aims to formulate the policy of productive green open space towards food security for poor people in Bandung. This research not only examines the role played by productive green open space to supply food for the urban poor but also how to govern urban areas sustainably and ensure food security. This research uses descriptive explanatory methodology that describes and explains how to generate policy and strategic planning for edible landscape to promote urban food security. Taman Sari is the location of this research, this area is a populous area that has amount of poor people and has a quite worse quality of urban environment. This study shows that urban green open space has the potential to be utilized as an urban farming land, which poor inhabitants could be main actors to manage urban agriculture to provide their food. Meanwhile, local government could contribute to subsidize the financial of urban farming activities.

Compound list: methylene dianiline [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available methylene dianiline DAPM 00155 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/methyle...es/LATEST/Rat/in_vivo/Liver/Single/methylene_dianiline.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc....jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/methylene_dianiline.Rat.in_vivo.Liver.Repeat.zip ... ...ne_dianiline.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggat

Present condition and theme of the planning standards of parks and open space planning. Koen ryokuchi keikaku gijutsu hyojun no genjo to kadai

Energy Technology Data Exchange (ETDEWEB)

Takanashi, M. (Kanagawa Prefectural Government, Kanagawa (Japan))

1992-08-06

With the dramatic progress of urbanization, the rapid decrease of the green area and the open space, which is basis for ensuring the safety and the comfort of city life and formation of a good city environment, lead to the worsen of city environment. For the basic purpose of achieving the harmony between development and environment by considering the preservation of the green area and the open space, the green master plan is a representative example, and was made as the constitution of from a ground plan to the various plans such as region, city and nation based on the space unit of developing the human action. One of the important planning approach for the green area plan from conception to implementation is the planning standards of park and open space planning. This paper introduced the change of the system about the planning standards of park and open space planning, and explained necessarily the present state of greens master plan about preservation of the national environment and adjustment the park and open space. 1tab.

Sixteen-week analysis of unaltered elastomeric chain relating in-vitro force degradation with in-vivo extraction space tooth movement.

Science.gov (United States)

Evans, Kristin S; Wood, Cory M; Moffitt, Allen H; Colgan, John A; Holman, J Kevin; Marshall, Steven D; Pope, D Spencer; Sample, Lew B; Sherman, Stephen L; Sinclair, Peter M; Trulove, Tim S

2017-04-01

The purposes of this study were to evaluate whether unaltered elastomeric chain can continue to move teeth for 16 weeks and to relate it to the amount of force remaining for the same batch of elastomeric chains. The in-vivo portion of the study had a sample of 30 paired extraction space sites from 22 subjects who were measured for closure of the space every 28 days. The altered side elastomeric chain served as the control and was replaced at 28-day intervals whereas the experimental side remained unaltered. In the in-vitro portion of the study, 100 each of 2-unit and 3-unit segments of the same batch of elastomeric chains were placed in a water bath, and the force was measured for 20 of each segment length at the 28-day measurement points. Statistically significant amounts of space closure occurred at both the altered and unaltered sites at all measurement time points. The mean space closure at the altered sites was minimally greater than that observed at the paired unaltered sites. The mean differences of space closure between the altered and unaltered sites ranged from a minimum of -0.05 mm at 4 weeks to a maximum of -0.14 mm at 8 weeks. The elastomeric chain force degraded rapidly by 4 weeks but continued a gradual diminution of force to 86 g at 16 weeks. Unaltered elastomeric chain continued to move teeth into extraction spaces for 16 weeks in this sample from both statistically and clinically significant standpoints. There were minimal and statistically insignificant differences in the mean space closure measurements between the paired altered and unaltered sites. The elastomeric chain force at 16 weeks was less than 100 g, yet at the same time point, teeth continued to move clinically. Copyright © 2016 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

GeneLab: NASA's Open Access, Collaborative Platform for Systems Biology and Space Medicine

Science.gov (United States)

Berrios, Daniel C.; Thompson, Terri G.; Fogle, Homer W.; Rask, Jon C.; Coughlan, Joseph C.

2015-01-01

NASA is investing in GeneLab1 (http:genelab.nasa.gov), a multi-year effort to maximize utilization of the limited resources to conduct biological and medical research in space, principally aboard the International Space Station (ISS). High-throughput genomic, transcriptomic, proteomic or other omics analyses from experiments conducted on the ISS will be stored in the GeneLab Data Systems (GLDS), an open-science information system that will also include a biocomputation platform with collaborative science capabilities, to enable the discovery and validation of molecular networks.

Compound list: valproic acid [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available valproic acid VPA 00005 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/valpr...oic_acid.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/valpr...oic_acid.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/valpr...edbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/valproic_acid.Rat.in_vivo.Liver.Repeat.zip ftp:...//ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/valproic_acid.Rat.in_vivo.Kidne

Compound list: vitamin A [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available vitamin A VA 00059 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/vitam...in_A.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/vitam...in_A.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/vitam...pen-tggates/LATEST/Rat/in_vivo/Liver/Repeat/vitamin_A.Rat.in_vivo.Liver.Repeat.zip ...

Natural woodland vegetation and plant species richness of the urban open spaces in Gauteng, South Africa

Directory of Open Access Journals (Sweden)

C.H. Grobler

2002-01-01

Full Text Available It is estimated that approximately 60 % of the world’s population will be living in urban areas by 2025. In Gauteng, the most densely populated province in South Africa, the natural open spaces are continually under threat from development. Vegetation is the most physical representation of the environment on which all animals are ultimately dependent. In order to evaluate an areas potential for development or conservation it is necessary to make a thorough inventory of the plant communities and their associated habitats. A survey of the natural woodlands was undertaken as part of a project describing the vegetation of the natural open spaces within the Gauteng region. Relevés were compiled in 73 stratified random sample plots in selected open spaces within the study area. A TWINSPAN classification, refined by Braun-Blanquet procedures, indicated six woodland communities that can be grouped into two major woodland communities. A classification and description of these communities as well as their species richness are presented. The results indicate that there are still patches of well-preserved natural vegetation within the study area and contribute to the limited knowledge that presently exists for the vegetation of the area.

Compound list: carbon tetrachloride [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available carbon tetrachloride CCL4 00003 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LAT...EST/Human/in_vitro/carbon_tetrachloride.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tgg...ates/LATEST/Rat/in_vitro/carbon_tetrachloride.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open...-tggates/LATEST/Rat/in_vivo/Liver/Single/carbon_tetrachloride.Rat.in_vivo.Liver.S...ingle.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/carbon_tetrachloride.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: amphotericin B [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available amphotericin B AMB 00157 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Hum...an/in_vitro/amphotericin_B.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/R...at/in_vivo/Liver/Single/amphotericin_B.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/archive/open-...tggates/LATEST/Rat/in_vivo/Liver/Repeat/amphotericin_B.Rat.in_vivo.Liver.Repeat.zip ftp:...//ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/amphotericin_B.Rat.in_vivo.Kidney.Single.zip ftp:

Compound list: cyclosporine A [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available cyclosporine A CSA 00142 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/cyclosporine..._A.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/cyclosporine.../in_vivo/Liver/Single/cyclosporine_A.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosc...iencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/cyclosporine_A.Rat.in_vivo.Liver.Repeat.zip... ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/cyclosporine_A.Rat.in_vivo

Space Industry Study Industrial College of the Armed Forces National Defense University

Science.gov (United States)

2002-06-01

information technologies , especially fiber, cable, and cellular communications, which forced space systems away from old market roles and denied entry to... technologies fill market niches. As technology matures, small satellites have been viewed a partial solution to this cycle, enabling faster programs...years, the largely unforeseen growth in the internet has proven a valuable new market for satellite service providers. And over the past few years

Open Space between Residential Buildings as a Factor of Sustainable Development - Case Studies in Brno (Czech Republic) and Vienna (Austria)

Science.gov (United States)

Kilnarová, Pavla; Wittmann, Maxmilian

2017-12-01

The characteristics of open spaces between residential buildings have, as authors suppose, an impact on the sustainable development of urban areas. Spatial arrangement and accessibility of these spaces, the type and height of surrounding buildings, the quantity and character of greenery, and many more characteristics influence the quality of environment, and the quality of life of local residents. These and further characteristics of the open spaces between residential buildings influence the ecological stability of the area, its hygienic qualities, the intensity and way of using by various social groups, and also the prices of real estates. These qualities indicate the environmental, social and economic sustainability of the urban area. The proposed research methodology assessed specific indicators of sustainability within a range from 0 to 10 points. 5 points correspond to the general standard in the area, 0 points indicate degradation, and 10 points indicate the highest contribution to sustainable development. Observation methods, questionnaire survey, statistical analyses, and methods of measurement were used to determine the values of the given indicators. The paper analyses the impact of the open spaces between residential buildings on sustainability via the case studies performed in the Central European cities of Brno, Czech Republic and Vienna, Austria. Two forms of residential urban structures in the City of Brno in the Czech Republic were selected for the analysis: the closed courtyards in the urban block from the 19th century and the open spaces in the housing estates constructed under socialism in the 20th century. The question is, if the different forms of spaces between residential buildings influence the sustainability of urban area and satisfaction of inhabitants in different ways. A complementary case study in Vienna indicates that inhabitants of a housing estate in Vienna, as well as inhabitants of housing estates in Brno, highly appreciate the

Effect of forced swim stress on wistar albino rats in various behavioral parameters

Directory of Open Access Journals (Sweden)

Ambareesha Kondam, Nilesh N Kate, Gaja Lakshmi, Suresh M, Chandrashekar M.

2012-09-01

Full Text Available Introduction: Stress is an important factor of depression that causes the changes in various body systems. The forced swim test is a commonly used stressor test where rats are forced to swim in specially constructed tanks for a particular period where there is behavioral activation characterized by vigorous swimming and diving to search for alternate routes of escape. Animal health including human has been shown to be affected by the stressful events of life inducing situation which alters cognition, learning memory and emotional responses, causing mental disorders like depression and anxiety and stress in rats. Methods: The experiment was carried out with 12 healthy albino Wistar female rats weighing about 150-180gms. The animals were randomly divided into two groups of six animals each. Group – I (control, Group – II (Stressed Group. Group –II rats are placed in plastic tanks for 45minutes for15 days. Temperature of water was maintained at 20˚C. During stress phase, the animals will be trained for forced swim test, behavioral changes observed by open field apparatus for emotions, and eight arm maze for memory & leaning, elevated plus maze for anxiety. Results: Forced swim stress causes to a significant change (p<0.05 on cognitive functions: motivation, learning and memory. Forced swim stress is the factor damaging the hippocampus causes repeated immobilization and produce atrophy of dendrites of pyramidal neurons and neuroendocrinological disturbances, controlled by the hypothalamo-pituitary-adrenal axis (HPA. Repeated stress in the form of forced swimming activates the free radical processes leading to an increase in lipid peroxidation in many tissues. Conclusion: This study reveals the effect of repeated forced swim stress causes wide range of adaptive changes in the central nervous system including the elevation of serotonin (5-HT metabolism and an increased susceptibility to affective disorders. The earlier findings have reported

Opened athletic-educational space - the condition of professional development of future teacher of physical culture is needed

Directory of Open Access Journals (Sweden)

Dragnev Y.V.

2012-04-01

Full Text Available It is shown that the opening of the sports and educational space is determined by the whole space, where the interaction of the activity of the pedagogical university with different educational institutions on the basis of integration, continuity of the educational process, aimed at physical education, the development of children and young people take place. It is revealed the importance of awareness of such concepts as the world educational space, the international educational space, the European higher education area, European space of higher education and educational space of the CIS countries.

77 FR 13261 - Request for Applications: The Community Forest and Open Space Conservation Program

Science.gov (United States)

2012-03-06

... DEPARTMENT OF AGRICULTURE Forest Service Request for Applications: The Community Forest and Open Space Conservation Program AGENCY: Forest Service. ACTION: Notice; Correction. SUMMARY: The Department..., published a document in the Federal Register of February 15, 2011, concerning requests for applications for...

Selection of body sway parameters according to their sensitivity and repeatability

Directory of Open Access Journals (Sweden)

Nejc Sarabon

2010-03-01

Full Text Available For the precise evaluation of body balance, static type of tests performed on a force plate are the most commonly used ones. In these tests, body sway characteristics are analyzed based on the model of inverted pendulum and looking at the center of pressure (COP movement in time. Human body engages different strategies to compensate for balance perturbations. For this reason, there is a need to identify parameters which are sensitive to specific balance changes and which enable us to identify balance sub-components. The aim of our study was to investigate intra-visit repeatability and sensibility of the 40 different body sway parameters. Twenty-nine subjects participated in the study. They performed three different balancing tasks of different levels of difficulty, three repetitions each. The hip-width parallel stance and the single leg stance, both with open eyes, were used as ways to compare different balance intensities due to biomechanical changes. Additionally, deprivation of vision was used in the third balance task to study sensitivity to sensory system changes. As shown by intraclass correlation coefficient (ICC, repeatability of cumulative parameters such as COP, maximal amplitude and frequency showed excellent repeatability (ICC>0,85. Other parameters describing sub-dynamics through single repetition proved to have unsatisfying repeatability. Parameters most sensitive to increased intensity of balancing tasks were common COP, COP in medio-lateral and in antero-posterior direction, and maximal amplitues in the same directions. Frequency of oscilations has proved to be sensitive only to deprivation of vision. As shown in our study, cumulative parameters describing the path which the center of pressure makes proved to be the most repeatable and sensitive to detect different increases of balancing tasks enabling future use in balance studies and in clinical practice.

Analysis of sub-nano spaces by positron annihilation spectroscopy

International Nuclear Information System (INIS)

Jean, Y.C.; Liu, J.; Huang, C.M.; Dai, G.H.; Yuan, J.P.

1994-01-01

Positron annihilation spectroscopy (PAS) has been realized to be a novel and potentially powerful tool to evolve the open spaces in the range 1-20 angstrom in molecular systems. Due to the repulsive force between the positron (the anti-particle of the electron) and the cores, annihilation signals are solely contributed from the open spaces, such as vacancies, holes, and voids in the molecular subtracts under study. By further developing two PAS techniques, positron lifetime (PAL), and angular correlation (ACAR), the authors are able to obtain useful and important information of: hole sizes, distributions, hole fractions, and anisotropic structures at sub-nano scales. Applications of PAS to chemical analysis, surface chemistry of inner pores, and polymer sciences are discussed

Opening Doors to Recovery: Recidivism and Recovery Among Persons With Serious Mental Illnesses and Repeated Hospitalizations.

Science.gov (United States)

Compton, Michael T; Kelley, Mary E; Pope, Alicia; Smith, Kelly; Broussard, Beth; Reed, Thomas A; DiPolito, June A; Druss, Benjamin G; Li, Charles; Lott Haynes, Nora

2016-02-01

Repeated hospitalizations and arrests or incarcerations diminish the ability of individuals with serious mental illnesses to pursue recovery. Community mental health systems need new models to address recidivism as well as service fragmentation, lack of engagement by local stakeholders, and poor communication between mental health providers and the police. This study examined the initial effects on institutional recidivism and measures of recovery among persons enrolled in Opening Doors to Recovery, an intensive, team-based community support program for persons with mental illness and a history of inpatient psychiatric recidivism. A randomized controlled trial of the model is underway. The number of hospitalizations, days hospitalized, and arrests (all from state administrative sources) in the year before enrollment and during the first 12 months of enrollment in the program were compared. Longitudinal trajectories of recovery-using three self-report and five clinician-rated measures-were examined. Analyses accounted for baseline symptom severity and intensity of involvement in the program. One hundred participants were enrolled, and 72 were included in the analyses. Hospitalizations decreased, from 1.9±1.6 to .6±.9 (precovery measures, and trajectories of improvement were apparent across the entire follow-up period. Opening Doors to Recovery holds promise as a new service approach for reducing hospital recidivism and promoting recovery in community mental health systems and is deserving of further controlled testing.

Community members’ initiatives in public open spaces: two case studies from Slovenia

Directory of Open Access Journals (Sweden)

Sabina Jelenc Krašovec

2017-10-01

Full Text Available The paper deals with public spaces as open, everyday arenas where people share experiences beyond their immediate circle of friends, family and age group. Public space is understood as a forum for social and personal change (Harvey, 2011; Lefebvre, 2013; Arendt, 1996; Habermas, 1989; 2001. Questions are analysed from the point of view of community members, who are strongly attached to the space and who are interested in belonging and in proactive changes in their living environment (Iecovich, 2014; Kohn 2004; Mean and Tims, 2005. The paper is based on the presumptions that public space has an important role in generating ideas and activities of community members and that it is an important venue for community members’ informal learning. Ethnomethodological research in two public spaces (the Tabor community in Ljubljana and a small community in the coastal town of Izola show that there are differences between both public spaces regarding top-down initiatives and bottom-up, self-organized activities. However, although the activity initiators were in one case different associations rooted in the community, and in the other the local people themselves, most of the activities were conducted by people living in the selected communities/public spaces themselves as is typical of grassroots activities. It was confirmed that learning was not often mentioned by members of either community and was mostly a hidden activity, resulting in tacit knowledge.

B→τν: Opening up the charged Higgs parameter space with R-parity violation

International Nuclear Information System (INIS)

Bose, Roshni; Kundu, Anirban

2012-01-01

The theoretically clean channel B + →τ + ν shows a close to 3σ discrepancy between the Standard Model prediction and the data. This in turn puts a strong constraint on the parameter space of a two-Higgs doublet model, including R-parity conserving supersymmetry. The constraint is so strong that it almost smells of fine-tuning. We show how the parameter space opens up with the introduction of suitable R-parity violating interactions, and release the tension between data and theory.

The return of "Gasoline station-park" status into green-open space in DKI Jakarta Province

Science.gov (United States)

Kautsar, L. H. R.; Waryono, T.; Sobirin

2017-07-01

The development of gasoline stations in 1970 increased drastically due to the Government support through DKT Jaya Official Note (DKT Jakarta), resulting in a great number of the parks (green open space or RTH - Ruang Terbuka Hijau) converted into a gasoline station. Currently, to meet the RTH target (13.94 % RTH based RTRW [(Rencana Tata Ruang Wilayah) DKT Jakarta 2010], the policy was changed by Decree No.728 year 2009 and Governor Tnstruction No.75 year 2009. Land function of 27 gasoline stations unit must be returned. This study is to determine the appropriateness of gasoline Station-Park conversion into RTH based site and situation approach. The scope of this study was limited only to gasoline stations not converted into RTH. The methodology was the combination of AHP (Analytical Hierarchy Process) and ranking method. Site variables were meant for prone to flooding, the width of land for gasoline station, land status. Situation variables were meant for other public space, availability of other gasoline stations, gasoline stations service, road segments, and the proportions of built space. Analysis study used quantitative descriptive analysis. The results were three of the five gasoline stations were congruence to be converted into a green open space (RTH).

Simulated non-contact atomic force microscopy for GaAs surfaces based on real-space pseudopotentials

International Nuclear Information System (INIS)

Kim, Minjung; Chelikowsky, James R.

2014-01-01

We simulate non-contact atomic force microscopy (AFM) with a GaAs(1 1 0) surface using a real-space ab initio pseudopotential method. While most ab initio simulations include an explicit model for the AFM tip, our method does not introduce the tip modeling step. This approach results in a considerable reduction of computational work, and also provides complete AFM images, which can be directly compared to experiment. By analyzing tip-surface interaction forces in both our results and previous ab initio simulations, we find that our method provides very similar force profile to the pure Si tip results. We conclude that our method works well for systems in which the tip is not chemically active.

Audible vision for the blind and visually impaired in indoor open spaces.

Science.gov (United States)

Yu, Xunyi; Ganz, Aura

2012-01-01

In this paper we introduce Audible Vision, a system that can help blind and visually impaired users navigate in large indoor open spaces. The system uses computer vision to estimate the location and orientation of the user, and enables the user to perceive his/her relative position to a landmark through 3D audio. Testing shows that Audible Vision can work reliably in real-life ever-changing environment crowded with people.

Compound list: naphthyl isothiocyanate [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available naphthyl isothiocyanate ANIT 00009 ftp://ftp.biosciencedbc.jp/archive/open-tggates/...LATEST/Human/in_vitro/naphthyl_isothiocyanate.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/op...en-tggates/LATEST/Rat/in_vitro/naphthyl_isothiocyanate.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/arc...hive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/naphthyl_isothiocyanate.Rat.in_...vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/naphthyl_isothiocyanate.Rat.in_vivo.Liver.Repeat.zip ...

Weak openness and almost openness

Directory of Open Access Journals (Sweden)

David A. Rose

1984-01-01

Full Text Available Weak openness and almost openness for arbitrary functions between topological spaces are defined as duals to the weak continuity of Levine and the almost continuity of Husain respectively. Independence of these two openness conditions is noted and comparison is made between these and the almost openness of Singal and Singal. Some results dual to those known for weak continuity and almost continuity are obtained. Nearly almost openness is defined and used to obtain an improved link from weak continuity to almost continuity.

Ab initio nonequilibrium quantum transport and forces with the real-space projector augmented wave method

DEFF Research Database (Denmark)

Chen, Jingzhe; Thygesen, Kristian S.; Jacobsen, Karsten W.

2012-01-01

We present an efficient implementation of a nonequilibrium Green's function method for self-consistent calculations of electron transport and forces in nanostructured materials. The electronic structure is described at the level of density functional theory using the projector augmented wave method...... over k points and real space makes the code highly efficient and applicable to systems containing several hundreds of atoms. The method is applied to a number of different systems, demonstrating the effects of bias and gate voltages, multiterminal setups, nonequilibrium forces, and spin transport....

AMPS sciences objectives and philosophy. [Atmospheric, Magnetospheric and Plasmas-in-Space project on Spacelab

Science.gov (United States)

Schmerling, E. R.

1975-01-01

The Space Shuttle will open a new era in the exploration of earth's near-space environment, where the weight and power capabilities of Spacelab and the ability to use man in real time add important new features. The Atmospheric, Magnetospheric, and Plasmas-in-Space project (AMPS) is conceived of as a facility where flexible core instruments can be flown repeatedly to perform different observations and experiments. The twin thrusts of remote sensing of the atmosphere below 120 km and active experiments on the space plasma are the major themes. They have broader implications in increasing our understanding of plasma physics and of energy conversion processes elsewhere in the universe.

Features of public open spaces and physical activity among children: findings from the CLAN study.

Science.gov (United States)

Timperio, Anna; Giles-Corti, Billie; Crawford, David; Andrianopoulos, Nick; Ball, Kylie; Salmon, Jo; Hume, Clare

2008-11-01

To examine associations between features of public open spaces, and children's physical activity. 163 children aged 8-9 years and 334 adolescents aged 13-15 years from Melbourne, Australia participated in 2004. A Geographic Information System was used to identify all public open spaces (POS) within 800 m of participants' homes and their closest POS. The features of all POS identified were audited in 2004/5. Accelerometers measured moderate-to-vigorous physical activity (MVPA) after school and on weekends. Linear regression analyses examined associations between features of the closest POS and participants' MVPA. Most participants had a POS within 800 m of their home. The presence of playgrounds was positively associated with younger boys' weekend MVPA (B=24.9 min/day; pPOS were associated with participants' MVPA, although mixed associations were evident. Further research is required to clarify these complex relationships.

Repeated Muscle Injury as a Presumptive Trigger for Chronic Masticatory Muscle Pain

Directory of Open Access Journals (Sweden)

Dean Dessem

2011-01-01

Full Text Available skeletal muscles sustain a significant loss of maximal contractile force after injury, but terminally damaged fibers can eventually be replaced by the growth of new muscle (regeneration, with full restoration of contractile force over time. After a second injury, limb muscles exhibit a smaller reduction in maximal force and reduced inflammation compared with that after the initial injury (i.e., repeated bout effect. In contrast, masticatory muscles exhibit diminished regeneration and persistent fibrosis, after a single injury; following a second injury, plasma extravasation is greater than after a single injury and maximal force is decreased more than after the initial injury. Thus, masticatory muscles do not exhibit a repeated bout effect and are instead increasingly damaged by repeated injury. We propose that the impaired ability of masticatory muscles to regenerate contributes to chronic muscle pain by leading to an accumulation of tissue damage, fibrosis, and a persistent elevation and prolonged membrane translocation of nociceptive channels such as P2X3 as well as enhanced expression of neuropeptides including CGRP within primary afferent neurons. These transformations prime primary afferent neurons for enhanced responsiveness upon subsequent injury thus triggering and/or exacerbating chronic muscle pain.

Suspicious Behavior Detection System for an Open Space Parking Based on Recognition of Human Elemental Actions

Science.gov (United States)

Inomata, Teppei; Kimura, Kouji; Hagiwara, Masafumi

Studies for video surveillance applications for preventing various crimes such as stealing and violence have become a hot topic. This paper proposes a new video surveillance system that can detect suspicious behaviors such as a car break-in and vandalization in an open space parking, and that is based on image processing. The proposed system has the following features: it 1)deals time series data flow, 2)recognizes “human elemental actions” using statistic features, and 3)detects suspicious behavior using Subspace method and AdaBoost. We conducted the experiments to test the performance of the proposed system using open space parking scenes. As a result, we obtained about 10.0% for false positive rate, and about 4.6% for false negative rate.

Confinement of plasma along shaped open magnetic fields from the centrifugal force of supersonic plasma rotation.

Science.gov (United States)

Teodorescu, C; Young, W C; Swan, G W S; Ellis, R F; Hassam, A B; Romero-Talamas, C A

2010-08-20

Interferometric density measurements in plasmas rotating in shaped, open magnetic fields demonstrate strong confinement of plasma parallel to the magnetic field, with density drops of more than a factor of 10. Taken together with spectroscopic measurements of supersonic E × B rotation of sonic Mach 2, these measurements are in agreement with ideal MHD theory which predicts large parallel pressure drops balanced by centrifugal forces in supersonically rotating plasmas.

Is There Space for the Objective Force?

National Research Council Canada - National Science Library

Coffin, Timothy

2003-01-01

The Army has launched itself on a daring trajectory toward the Objective Force. It will transform the Army forces into a more lethal and devastating force through the combination of precision weapons and knowledge-based warfare...

Emittance growth due to static and radiative space charge forces in an electron bunch compressor

Science.gov (United States)

Talman, Richard; Malitsky, Nikolay; Stulle, Frank

2009-01-01

-21, MOCOS05, available at http://www.JACoW.org], a code with similar capabilities. For this comparison an appropriately new, 50 MeV, “standard chicane” is introduced. Unlike CSRTrack (which neglects vertical forces) the present simulation shows substantial growth of vertical emittance. But “turning off” vertical forces in the UAL code (to match the CSRTrack treatment) brings the two codes into excellent agreement. (iii) Results are also obtained for 5 GeV electrons passing through a previously introduced “standard chicane” [Coherent Synchrotron Radiation, CSR Workshop, Berlin 2002, http://www.desy.de/csr] [of the sort needed for linear colliders and free electron lasers (FEL’s) currently under design or construction]. Relatively little emittance growth is predicted for typical bunch parameters at such high electron energy. Results are obtained for both round beams and ribbon beams (like those actually needed in practice). Little or no excess emittance growth is found for ribbon bunches compared to round bunches of the same charge and bunch width. The UAL string space charge formulation (like TraFic4 and CSRTrack) avoids the regularization step (subtracting the free-space space charge force) which is required (to remove divergence) in some methods. Also, by avoiding the need to calculate a retarded-time, four-dimensional field history, the computation time needed for realistic bunch evolution calculations is modest. Some theories of bunch dilution, because they ascribe emittance growth entirely to CSR, break down at low energy. In the present treatment, as well as CSR, all free-space Coulomb and magnetic space charge forces (but not image forces), and also the centrifugal space charge force (CSCF) are included. Charge-dependent beam steering due to CSCF, as observed recently by Beutner et al. [B. Beutner , in Proceedings of FEL Conference, BESSY, Berlin, Germany, 2006, MOPPH009], is also investigated.

Emittance growth due to static and radiative space charge forces in an electron bunch compressor

Directory of Open Access Journals (Sweden)

Richard Talman

2009-01-01

2004 FEL Conference, pp. 18–21, MOCOS05, available at http://www.JACoW.org], a code with similar capabilities. For this comparison an appropriately new, 50 MeV, “standard chicane” is introduced. Unlike CSRTrack (which neglects vertical forces the present simulation shows substantial growth of vertical emittance. But “turning off” vertical forces in the UAL code (to match the CSRTrack treatment brings the two codes into excellent agreement. (iii Results are also obtained for 5 GeV electrons passing through a previously introduced “standard chicane” [Coherent Synchrotron Radiation, CSR Workshop, Berlin 2002, http://www.desy.de/csr] [of the sort needed for linear colliders and free electron lasers (FEL’s currently under design or construction]. Relatively little emittance growth is predicted for typical bunch parameters at such high electron energy. Results are obtained for both round beams and ribbon beams (like those actually needed in practice. Little or no excess emittance growth is found for ribbon bunches compared to round bunches of the same charge and bunch width. The UAL string space charge formulation (like TraFic4 and CSRTrack avoids the regularization step (subtracting the free-space space charge force which is required (to remove divergence in some methods. Also, by avoiding the need to calculate a retarded-time, four-dimensional field history, the computation time needed for realistic bunch evolution calculations is modest. Some theories of bunch dilution, because they ascribe emittance growth entirely to CSR, break down at low energy. In the present treatment, as well as CSR, all free-space Coulomb and magnetic space charge forces (but not image forces, and also the centrifugal space charge force (CSCF are included. Charge-dependent beam steering due to CSCF, as observed recently by Beutner et al. [B. Beutner et al., in Proceedings of FEL Conference, BESSY, Berlin, Germany, 2006, MOPPH009], is also investigated.

Dynamics of space and polarization charges of ferroelectric thin films measured by atomic force microscopy

International Nuclear Information System (INIS)

Oh, Y.J.; Lee, J.H.; Jo, W.

2006-01-01

Retention behavior and local hysteresis characteristics in Pb(Zr 0.52 Ti 0.48 )O 3 (PZT) thin films on Pt electrodes have been investigated by electrostatic force microscopy (EFM). A sol-gel method is used to synthesize PZT thin films and drying conditions are carefully explored over a wide range of temperature. Decay and retention mechanisms of single-poled and reverse-poled regions of the ferroelectric thin films are explained by space charge redistribution. Trapping behavior of space charges is dependent on the nature of interface between ferroelectric thin films and bottom electrodes. Local measurement of polarization-electric field curves by EFM shows inhomogeneous space charge entrapment

Mapping urban green open space in Bontang city using QGIS and cloud computing

Science.gov (United States)

Agus, F.; Ramadiani; Silalahi, W.; Armanda, A.; Kusnandar

2018-04-01

Digital mapping techniques are available freely and openly so that map-based application development is easier, faster and cheaper. A rapid development of Cloud Computing Geographic Information System makes this system can help the needs of the community for the provision of geospatial information online. The presence of urban Green Open Space (GOS) provide great benefits as an oxygen supplier, carbon-binding agent and can contribute to providing comfort and beauty of city life. This study aims to propose a platform application of GIS Cloud Computing (CC) of Bontang City GOS mapping. The GIS-CC platform uses the basic map available that’s free and open source. The research used survey method to collect GOS data obtained from Bontang City Government, while application developing works Quantum GIS-CC. The result section describes the existence of GOS Bontang City and the design of GOS mapping application.

TSUNAMI LOADING ON BUILDINGS WITH OPENINGS

Directory of Open Access Journals (Sweden)

P. Lukkunaprasit

2009-01-01

Full Text Available Reinforced concrete (RC buildings with openings in the masonry infill panels have shown superior performance to those without openings in the devastating 2004 Indian Ocean Tsunami. Understanding the effect of openings and the resulting tsunami force is essential for an economical and safe design of vertical evacuation shelters against tsunamis. One-to-one hundred scale building models with square shape in plan were tested in a 40 m long hydraulic flume with 1 m x 1 m cross section. A mild slope of 0.5 degree representing the beach condition at Phuket, Thailand was simulated in the hydraulic laboratory. The model dimensions were 150 mm x 150 mm x 150 mm. Two opening configurations of the front and back walls were investigated, viz., 25% and 50% openings. Pressure sensors were placed on the faces of the model to measure the pressure distribution. A high frequency load cell was mounted at the base of the model to record the tsunami forces. A bi-linear pressure profile is proposed for determining the maximum tsunami force acting on solid square buildings. The influence of openings on the peak pressures on the front face of the model is found to be practically insignificant. For 25% and 50% opening models, the tsunami forces reduce by about 15% and 30% from the model without openings, respectively. The reduction in the tsunami force clearly demonstrates the benefit of openings in reducing the effect of tsunami on such buildings.

Clinical Utilization of Repeated Open Application Test Among American Contact Dermatitis Society Members.

Science.gov (United States)

Brown, Gabrielle E; Botto, Nina; Butler, Daniel C; Murase, Jenny E

2015-01-01

The repeated open application test (ROAT) provides useful information regarding allergens in suspected cases of allergic contact dermatitis; however, standardized methodology has not been established. The aim of this study was to assess how ROAT is used in clinical and research settings. We distributed a survey regarding ROAT practice to the American Contact Dermatitis Society and conducted a literature review of ROAT utilization in research. A total of 67 American Contact Dermatitis Society members participated in the survey. Respondents most frequently recommend application of leave-on products twice daily (46.0%) and rinse-off products once daily (43.5%). The most commonly used anatomical sites include the forearm (38.7%) and antecubital fossa (32.3%). Most respondents continue ROAT for 1 (49.2%) or 2 weeks (31.7%). Literature review of 32 studies (26 leave-on, 6 rinse-off) revealed that application frequency is most common at twice daily for both leave-on (96.2%) and rinse-off (50.0%) products. The most common anatomical site is the forearm (62.5%), with an overall study duration of 3 to 4 weeks (65.6%). When comparing ROAT clinical and research practice, the majority trend was consistent for leave-on product application frequency and anatomical site, but not for rinse-off product application frequency, or overall duration. Further research is needed to determine best practice recommendations.

Learning to push and learning to move: The adaptive control of contact forces

Directory of Open Access Journals (Sweden)

Maura eCasadio

2015-11-01

Full Text Available To be successful at manipulating objects one needs to apply simultaneously well controlled movements and contact forces. We present a computational theory of how the brain may successfully generate a vast spectrum of interactive behaviors by combining two independent processes. One process is competent to control movements in free space and the other is competent to control contact forces against rigid constraints. Free space and rigid constraints are singularities at the boundaries of a continuum of mechanical impedance. Within this continuum, forces and motions occur in compatible pairs connected by the equations of Newtonian dynamics. The force applied to an object determines its motion. Conversely, inverse dynamics determine a unique force trajectory from a movement trajectory. In this perspective, we describe motor learning as a process leading to the discovery of compatible force/motion pairs. The learned compatible pairs constitute a local representation of the environment's mechanics. Experiments on force field adaptation have already provided us with evidence that the brain is able to predict and compensate the forces encountered when one is attempting to generate a motion. Here, we tested the theory in the dual case, i.e. when one attempts at applying a desired contact force against a simulated rigid surface. If the surface becomes unexpectedly compliant, the contact point moves as a function of the applied force and this causes the applied force to deviate from its desired value. We found that, through repeated attempts at generating the desired contact force, subjects discovered the unique compatible hand motion. When, after learning, the rigid contact was unexpectedly restored, subjects displayed after effects of learning, consistent with the concurrent operation of a motion control system and a force control system. Together, theory and experiment support a new and broader view of modularity in the coordinated control of forces and

Bupleurum falcatum prevents depression and anxiety-like behaviors in rats exposed to repeated restraint stress.

Science.gov (United States)

Lee, Bombi; Yun, Hye-Yeon; Shim, Insop; Lee, Hyejung; Hahm, Dae-Hyun

2012-03-01

Previous studies have demonstrated that repeated restraint stress in rodents produces increases in depression and anxietylike behaviors and alters the expression of corticotrophinreleasing factor (CRF) in the hypothalamus. The current study focused on the impact of Bupleurum falcatum (BF) extract administration on repeated restraint stress-induced behavioral responses using the forced swimming test (FST) and elevated plus maze (EPM) test. Immunohistochemical examinations of tyrosine hydroxylase (TH) expression in rat brain were also conducted. Male rats received daily doses of 20, 50, or 100 mg/kg (i.p.) BF extract for 15 days, 30 min prior to restraint stress (4 h/day). Hypothalamicpituitary- adrenal axis activation in response to repeated restraint stress was confirmed base on serum corticosterone levels and CRF expression in the hypothalamus. Animals that were pre-treated with BF extract displayed significantly reduced immobility in the FST and increased open-arm exploration in the EPM test in comparison with controls. BF also blocked the increase in TH expression in the locus coeruleus of treated rats that experienced restraint stress. Together, these results demonstrate that BF extract administration prior to restraint stress significantly reduces depression and anxiety-like behaviors, possibly through central adrenergic mechanisms, and they suggest a role for BF extract in the treatment of depression and anxiety disorders.

An Electro-thermal MEMS Gripper with Large Tip Opening and Holding Force: Design and Characterization

Directory of Open Access Journals (Sweden)

Jay J. KHAZAAI

2011-12-01

Full Text Available This paper presents the design, fabrication, and characterization of a novel MEMS gripper that is driven electro-thermally by a new V-shape actuator (VSA and a set of modified Guckel U-shape actuators (mUSA. The modification of the angle between the hot and cold arms in the mUSA facilitates unidirectional in-plane displacement causing the opening of the gripper. This configuration distinguishes the MEMS gripper from others in its ability to generate larger tip displacement and greater holding force. The metallic structures allow for a low operating voltage and low overall power consumption. A tip opening of 173.4 μm has been measured at the operating voltage of 1 V with consuming power of 0.85 W. MetalMUMPs is employed to fabricate the device, in which electroplated nickel is used as the structural material.

Entropic force, holography and thermodynamics for static space-times

International Nuclear Information System (INIS)

Konoplya, R.A.

2010-01-01

Recently Verlinde has suggested a new approach to gravity which interprets gravitational interaction as a kind of entropic force. The new approach uses the holographic principle by stating that the information is kept on the holographic screens which coincide with equipotential surfaces. Motivated by this new interpretation of gravity (but not being limited by it) we study equipotential surfaces, the Unruh-Verlinde temperature, energy and acceleration for various static space-times: generic spherically symmetric solutions, axially symmetric black holes immersed in a magnetic field, traversable spherically symmetric wormholes of an arbitrary shape function, system of two and more extremely charged black holes in equilibrium. In particular, we have shown that the Unruh-Verlinde temperature of the holographic screen reaches absolute zero on the wormhole throat independently of the particular form of the wormhole solution. (orig.)

Compound list: butylated hydroxyanisole [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available butylated hydroxyanisole BHA 00156 ftp://ftp.biosciencedbc.jp/archive/open-tggates/...LATEST/Human/in_vitro/butylated_hydroxyanisole.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/o...pen-tggates/LATEST/Rat/in_vivo/Liver/Single/butylated_hydroxyanisole.Rat.in_vivo.Liver.Single.zip ftp://ftp....biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/butylated_hydroxyanisole.Rat.in_vivo.Liver.Repeat.zip ...

Compound list: fluoxetine hydrochloride [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available fluoxetine hydrochloride FLX 00158 ftp://ftp.biosciencedbc.jp/archive/open-tggates/...LATEST/Human/in_vitro/fluoxetine_hydrochloride.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/o...pen-tggates/LATEST/Rat/in_vivo/Liver/Single/fluoxetine_hydrochloride.Rat.in_vivo.Liver.Single.zip ftp://ftp....biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/fluoxetine_hydrochloride.Rat.in_vivo.Liver.Repeat.zip ...

ACCESS TO PUBLIC OPEN SPACE: IS DISTRIBUTION EQUITABLE ACROSS DIFFERENT SOCIO-ECONOMIC AREAS

Directory of Open Access Journals (Sweden)

Mohammad Javad Koohsari

2011-12-01

Full Text Available During the past decade, the role of the built environment on physical activity has been well investigated by public health, transportation and urban design scholars and it has been shown that different aspects of the built environment can influence physical activity Public open spaces (POS like parks have many health benefits and they can be important settings and destinations for having physical activity. Inequality in access to POS which may influence the amount of physical activity can be a reason for lower physical activity among deprived neighbourhoods. This paper aims to examine whether objective access to public open spaces (POS like parks is equally across the different socio-economic status (SES areas in the City of Melbourne. Objective access to POS was measured in network distance using geographic information systems (GIS and area SES was obtained using the SEIFA (Socio-Economic Indexes for Areas index. The results showed there was a significant difference in access to POS according to the SES areas. There was a significant negative correlation between the access to POS and the SES areas in which lower SES areas had poorer access to POS in comparison with the higher ones.

Open source posturography.

Science.gov (United States)

Rey-Martinez, Jorge; Pérez-Fernández, Nicolás

2016-12-01

The proposed validation goal of 0.9 in intra-class correlation coefficient was reached with the results of this study. With the obtained results we consider that the developed software (RombergLab) is a validated balance assessment software. The reliability of this software is dependent of the used force platform technical specifications. Develop and validate a posturography software and share its source code in open source terms. Prospective non-randomized validation study: 20 consecutive adults underwent two balance assessment tests, six condition posturography was performed using a clinical approved software and force platform and the same conditions were measured using the new developed open source software using a low cost force platform. Intra-class correlation index of the sway area obtained from the center of pressure variations in both devices for the six conditions was the main variable used for validation. Excellent concordance between RombergLab and clinical approved force platform was obtained (intra-class correlation coefficient =0.94). A Bland and Altman graphic concordance plot was also obtained. The source code used to develop RombergLab was published in open source terms.

An Experimental Study on the Influence of Soundscapes on People's Behaviour in an Open Public Space

OpenAIRE

Aletta, F.; Lepore, F.; Kostara-Konstantinou, E.; Kang, J.; Astolfi, A.

2016-01-01

Several studies have investigated how environmental sounds and music can modulate people’s behaviours, particularly in marketing research. However, there are relatively few examples of research about such relationships with a focus on the management of urban public spaces. The current study investigated an open public space used mainly as a pedestrian crossing to analyse the relationship between the audio stimuli and peoples’ behaviours. An experiment relying on covert behavioural observation...

Evolutionary force of AT-rich repeats to trap genomic and episomal DNAs into the rice genome: lessons from endogenous pararetrovirus.

Science.gov (United States)

Liu, Ruifang; Koyanagi, Kanako O; Chen, Sunlu; Kishima, Yuji

2012-12-01

In plant genomes, the incorporation of DNA segments is not a common method of artificial gene transfer. Nevertheless, various segments of pararetroviruses have been found in plant genomes in recent decades. The rice genome contains a number of segments of endogenous rice tungro bacilliform virus-like sequences (ERTBVs), many of which are present between AT dinucleotide repeats (ATrs). Comparison of genomic sequences between two closely related rice subspecies, japonica and indica, allowed us to verify the preferential insertion of ERTBVs into ATrs. In addition to ERTBVs, the comparative analyses showed that ATrs occasionally incorporate repeat sequences including transposable elements, and a wide range of other sequences. Besides the known genomic sequences, the insertion sequences also represented DNAs of unclear origins together with ERTBVs, suggesting that ATrs have integrated episomal DNAs that would have been suspended in the nucleus. Such insertion DNAs might be trapped by ATrs in the genome in a host-dependent manner. Conversely, other simple mono- and dinucleotide sequence repeats (SSR) were less frequently involved in insertion events relative to ATrs. Therefore, ATrs could be regarded as hot spots of double-strand breaks that induce non-homologous end joining. The insertions within ATrs occasionally generated new gene-related sequences or involved structural modifications of existing genes. Likewise, in a comparison between Arabidopsis thaliana and Arabidopsis lyrata, the insertions preferred ATrs to other SSRs. Therefore ATrs in plant genomes could be considered as genomic dumping sites that have trapped various DNA molecules and may have exerted a powerful evolutionary force. © 2012 The Authors. The Plant Journal © 2012 Blackwell Publishing Ltd.

Instrumented figure skating blade for measuring on-ice skating forces

Science.gov (United States)

Acuña, S. A.; Smith, D. M.; Robinson, J. M.; Hawks, J. C.; Starbuck, P.; King, D. L.; Ridge, S. T.; Charles, S. K.

2014-12-01

Competitive figure skaters experience substantial, repeated impact loading during jumps and landings. Although these loads, which are thought to be as high as six times body weight, can lead to overuse injuries, it is not currently possible to measure these forces on-ice. Consequently, efforts to improve safety for skaters are significantly limited. Here we present the development of an instrumented figure skating blade for measuring forces on-ice. The measurement system consists of strain gauges attached to the blade, Wheatstone bridge circuit boards, and a data acquisition device. The system is capable of measuring forces in the vertical and horizontal directions (inferior-superior and anterior-posterior directions, respectively) in each stanchion with a sampling rate of at least 1000 Hz and a resolution of approximately one-tenth of body weight. The entire system weighs 142 g and fits in the space under the boot. Calibration between applied and measured force showed excellent agreement (R > 0.99), and a preliminary validation against a force plate showed good predictive ability overall (R ≥ 0.81 in vertical direction). The system overestimated the magnitude of the first and second impact peaks but detected their timing with high accuracy compared to the force plate.

Multimegawatt space nuclear power open-cycle MHD-facility

International Nuclear Information System (INIS)

Pavshuk, V.A.; Panchenko, V.P.

2008-01-01

Paper presents the results of the efforts to calculate the characteristics, the layout and the engineering design of the open cycle space power propulsion on the basis of the high-temperature nuclear reactor for a nuclear rocket engine and the Faraday 20 MW capacity MHD-generator. The IVG-1 heterogeneous channel-vessel reactor ensuring in the course of the experiments hydrogen heating up to 3100 K, up to 5 MPa pressure at the reactor core outlet, up to 5 kg/s flowsheet, up to 220 MW thermal power served as a reactor is considered. One determined the MHD-generator basic parameters, namely: the portion of Cs dope was equal to 20%, the outlet stagnation pressure - 2 MPa, the electric conductivity - ≅30 S/m, the Mach number - ≅0.7, the magnetic field induction - 6 T, the capacity - 20 MW, the specific power removal - ∼4 MJ/kg. Paper describes the design of the MHD-facility with the working fluid momentless discharge and its basic characteristics [ru

Overview: Routes to Open Access

OpenAIRE

Tullney, Marco; van Wezenbeek, Wilma

2017-01-01

Slides of an overview presentation given at a CESAER workshop on Open Access, February 2nd, 2017, in Brussels Cover major routes to more open access as discussed in the Task Force Open Science of CESAER: (national) open access strategies open access mandates open access incentives open access awareness open access publishing open access infrastructure

Comparison of clasp retention on enamel and composite resin-recontoured abutments following repeated removal in vitro.

Science.gov (United States)

Zarrati, Simindokht; Sadighpour, Leyla; Jahanian, Ghasem

2010-04-01

Loss of prosthetic retention over time is a concern with removable prostheses. Use of composite resin to modify an abutment contour receiving a removable partial denture clasp may offer a reasonable, less invasive method of improving removable prosthesis retention. The purpose of this study was to evaluate the removal force of clasps over composite resin-recontoured abutments during a simulated 4 years of service. Twenty first mandibular premolars were selected to form 2 groups of specimens (n=5) resembling a tooth-supported edentulous space. A packable composite resin (Filtek P60) was used to create a 0.25-mm undercut on the buccal abutment surfaces of the composite resin group. Teeth in the natural abutment group were mounted in angulation to produce 0.25-mm undercuts on the buccal surfaces. The chrome-cobalt framework consisted of 2 individually fabricated T-clasps. Both groups were subjected to 4500 cycles of repeated removal using a small shaker. Removal forces were recorded before the repeated removal test (T(0)), after 500 and 1000 cycles, and at 1000-cycle intervals thereafter. The mean values of forces between the 2 groups were compared at each stage using the Mann-Whitney test (alpha=.05). No debonding occurred during the test. At T(0), the highest and lowest force values were observed in the composite resin group (3.75 N and 17.5 N, respectively). There was a significant difference between the removal forces of the 2 groups after 500 cycles and at test completion (P=.008). Retention loss was 3 times greater in the composite resin group than in the natural abutments group (53.65% vs. 15.80%). Within the limitations of the study, removal forces of the composite resin-recontoured abutments were threefold less than those of natural abutments after 4 years of simulated service. Copyright 2010 The Editorial Council of the Journal of Prosthetic Dentistry. Published by Mosby, Inc. All rights reserved.

Implementation of the Forest Service Open Space Conservation Strategy in Washington State: Exploring the Role of the National Forest System

Science.gov (United States)

Richard J. Pringle; Lee K. Cerveny; Gordon A. Bradley

2015-01-01

The loss of open space was declared one of the “four threats to the health of our nation’s forests” by former USDA Forest Service Chief Dale Bosworth in 2004. Since then, the agencywide Open Space Conservation Strategy (OSCS) was released and the “four threats” were incorporated into the agency’s National Strategic Plan. These actions indicate that the OSCS is in the...

The social aspects of landscape change: protecting open space under the pressure of development

Science.gov (United States)

Paul H. Gobster; Susan I. Stewart; David N. Bengston

2004-01-01

The extent of developed land in many parts of the world has increased rapidly in recent decades, posing significant challenges to the protection of forests, agricultural lands, and other natural and culturally modified green areas in urban and rural settings. Sustaining these open spaces has long been seen as a critical issue economically, and it is now increasingly...

Applied Joint-Space Torque and Stiffness Control of Tendon-Driven Fingers

Science.gov (United States)

Abdallah, Muhammad E.; Platt, Robert, Jr.; Wampler, Charles W.; Hargrave, Brian

2010-01-01

Existing tendon-driven fingers have applied force control through independent tension controllers on each tendon, i.e. in the tendon-space. The coupled kinematics of the tendons, however, cause such controllers to exhibit a transient coupling in their response. This problem can be resolved by alternatively framing the controllers in the joint-space of the manipulator. This work presents a joint-space torque control law that demonstrates both a decoupled and significantly faster response than an equivalent tendon-space formulation. The law also demonstrates greater speed and robustness than comparable PI controllers. In addition, a tension distribution algorithm is presented here to allocate forces from the joints to the tendons. It allocates the tensions so that they satisfy both an upper and lower bound, and it does so without requiring linear programming or open-ended iterations. The control law and tension distribution algorithm are implemented on the robotic hand of Robonaut-2.

Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats.

Directory of Open Access Journals (Sweden)

Daniel Duzdevich

2011-02-01

Full Text Available In the R6/2 mouse model of Huntington's disease (HD, expansion of the CAG trinucleotide repeat length beyond about 300 repeats induces a novel phenotype associated with a reduction in transcription of the transgene.We analysed the structure of polymerase chain reaction (PCR-generated DNA containing up to 585 CAG repeats using atomic force microscopy (AFM. As the number of CAG repeats increased, an increasing proportion of the DNA molecules exhibited unusual structural features, including convolutions and multiple protrusions. At least some of these features are hairpin loops, as judged by cross-sectional analysis and sensitivity to cleavage by mung bean nuclease. Single-molecule force measurements showed that the convoluted DNA was very resistant to untangling. In vitro replication by PCR was markedly reduced, and TseI restriction enzyme digestion was also hindered by the abnormal DNA structures. However, significantly, the DNA gained sensitivity to cleavage by the Type III restriction-modification enzyme, EcoP15I."Super-long" CAG repeats are found in a number of neurological diseases and may also appear through CAG repeat instability. We suggest that unusual DNA structures associated with super-long CAG repeats decrease transcriptional efficiency in vitro. We also raise the possibility that if these structures occur in vivo, they may play a role in the aetiology of CAG repeat diseases such as HD.

Powerful and large regional authorities are needed to preserve green open space for urban agglomerations

Directory of Open Access Journals (Sweden)

Carmen Aalbers

2013-10-01

Full Text Available Identification and assessment of strategies for the conservation and multifunctional development of green open space in the urban fringe of European urban regions is a challenge to both the academic and the real life world. Within the EU funded research project PLUREL – Peri-urban land use relationships – ‘Strategies and sustainability assessment tools for urban rural linkages’, we developed a methodology for international comparison of regional strategies that considers the policy context at supra-regional level. This methodology helped to explain the reported impacts of strategies. For this we further elaborated the theoretical concept of policy arrangements and policy dimensions by Van Tatenhove et al. (2000 and Arts et al. (2006. Strategies and policy contexts referred to are from Montpellier Agglomeration, a formal coalition of now 31 municipalities, Leipzig-Halle region, a functional urban region (FUR with governance coalitions around green open space preservation strategies, and Hangzhou in China, a very large city with hierarchical formal government. Results showed how the means of influence from different government levels can complement and reinforce each other and raise the effectiveness of the strategies. A combination of hierarchical government with a horizontal coalition between local authorities covering the full FUR can be very effective for managing the land use developments in the urban fringe, even when private business, CSOs or other NGOs are not included in the coalition. Supra-regional authorities do not have to possess the land resources, but setting the Rules of the Game is a powerful means of influence to coerce local municipalities to preserve green open space in the urban fringe.

Active living : the impact of renovating urban open spaces on increasing the level of physical activity among social groups

NARCIS (Netherlands)

Wiggers, Hiske; Shokoohi, Roya

2017-01-01

Introduction The provision of active parks/public open space is the key factor in promoting active living, because people and specially low-income and elderlies are being more interested in doing non-organized/informal, and no-cost sports/physical activities in outdoor spaces in recent decades

An open source, 3D printed preclinical MRI phantom for repeated measures of contrast agents and reference standards.

Science.gov (United States)

Cox, B L; Ludwig, K D; Adamson, E B; Eliceiri, K W; Fain, S B

2018-03-01

In medical imaging, clinicians, researchers and technicians have begun to use 3D printing to create specialized phantoms to replace commercial ones due to their customizable and iterative nature. Presented here is the design of a 3D printed open source, reusable magnetic resonance imaging (MRI) phantom, capable of flood-filling, with removable samples for measurements of contrast agent solutions and reference standards, and for use in evaluating acquisition techniques and image reconstruction performance. The phantom was designed using SolidWorks, a computer-aided design software package. The phantom consists of custom and off-the-shelf parts and incorporates an air hole and Luer Lock system to aid in flood filling, a marker for orientation of samples in the filled mode and bolt and tube holes for assembly. The cost of construction for all materials is under $90. All design files are open-source and available for download. To demonstrate utility, B 0 field mapping was performed using a series of gadolinium concentrations in both the unfilled and flood-filled mode. An excellent linear agreement (R 2 >0.998) was observed between measured relaxation rates (R 1 /R 2 ) and gadolinium concentration. The phantom provides a reliable setup to test data acquisition and reconstruction methods and verify physical alignment in alternative nuclei MRI techniques (e.g. carbon-13 and fluorine-19 MRI). A cost-effective, open-source MRI phantom design for repeated quantitative measurement of contrast agents and reference standards in preclinical research is presented. Specifically, the work is an example of how the emerging technology of 3D printing improves flexibility and access for custom phantom design.

Historic Learning Approach for Auto-tuning OpenACC Accelerated Scientific Applications

KAUST Repository

Siddiqui, Shahzeb

2015-04-17

The performance optimization of scientific applications usually requires an in-depth knowledge of the hardware and software. A performance tuning mechanism is suggested to automatically tune OpenACC parameters to adapt to the execution environment on a given system. A historic learning based methodology is suggested to prune the parameter search space for a more efficient auto-tuning process. This approach is applied to tune the OpenACC gang and vector clauses for a better mapping of the compute kernels onto the underlying architecture. Our experiments show a significant performance improvement against the default compiler parameters and drastic reduction in tuning time compared to a brute force search-based approach.

Factors Influencing Visitors to Suburban Open Space Areas near a Northern Japanese City

Directory of Open Access Journals (Sweden)

Yasushi Shoji

2012-04-01

Full Text Available Visitor information often serves as the basis for the management plan of parks. However, there exist few scientific and fundamental surveys for parks and open spaces in Japan. We analyzed the correlation between the number of visitors and the various factors in a suburban open space in a northern Japanese city, Takino Park. To explain the fluctuations in the number of visitors in Takino Park, multiple regression analyses with the stepwise method were conducted. The analyses employed social factors and meteorological factors, such as the day of the week, school vacations, temperature and the weather. The results show that the most influential factor is the day of the week, i.e., Sundays and holidays. The weather is also influential as the number of visitors decreases on rainy and snowy days. Comparing different seasons of the year, we found that influential factors varied from one season to the other. A key distinguishing finding of our results is that the weather conditions at the departure site and the weather forecast are also determining factors. These findings will help park managers understand the current situations and examine future management strategies to maintain and enhance visitor satisfaction, and improve information services.

Technology collaboration by means of an open source government

Science.gov (United States)

Berardi, Steven M.

2009-05-01

The idea of open source software originally began in the early 1980s, but it never gained widespread support until recently, largely due to the explosive growth of the Internet. Only the Internet has made this kind of concept possible, bringing together millions of software developers from around the world to pool their knowledge. The tremendous success of open source software has prompted many corporations to adopt the culture of open source and thus share information they previously held secret. The government, and specifically the Department of Defense (DoD), could also benefit from adopting an open source culture. In acquiring satellite systems, the DoD often builds walls between program offices, but installing doors between programs can promote collaboration and information sharing. This paper addresses the challenges and consequences of adopting an open source culture to facilitate technology collaboration for DoD space acquisitions. DISCLAIMER: The views presented here are the views of the author, and do not represent the views of the United States Government, United States Air Force, or the Missile Defense Agency.

Expose-R experiment on effects of open space condition on survivorship in dormant stages of aquatic invertebrates

Science.gov (United States)

Alekseev, Victor; Novikova, Nataliya; Levinskikh, Margarita; Sychev, Vladimir; Yusoff, Fatimah; Azuraidi, Osman

2012-07-01

Dormancy protects animals and plants in harsh environmental conditions from months up to hundred years. This phenomenon is perspective for space researches especially for interplanetary missions. Direct experiments in open space BYORYSK supported in principle the fact of survivorship of bacteria, fungi spores, seed of plants and crustacean dormant cysts. Even though the rate of survivorship in long-term treatments was low but good enough to conclude that biological invasion even to Mars is a real danger. As soon as the BYORYSK lunch was made of metal the possibility for resting stages to survive under UV treatment in vacuum without some protection was not clear. To test it an ESA and RSA equipment titled EXPOSE-R was applied. The EXPOSE-R facility was an external facility attached to the outside of the Zvezda Service Module in ISS in the end of November 2008. It had glace windows transparent for UV-radiation and possibility to measure temperature, space- and UV-radiation. Among a number of experiments requiring exposure to the open space environment it had a biological launch containing resting stages of terrestrial and aquatic organisms. These stages included dried ephippia of cladoceran Daphnia magna differentiated on size, dormant eggs of ostracode Eucypris ornate, cysts of fair-shrimp Streptocephalus torvicornis ( all from hemi desert Caspian area) and Artemis salina from salt lake Crimean populations. All dormant stages were kept in transparent to UV plastic bags placed in three layers. After about two years of exposing in open space dormant stages of 3 species A. salina, D. magna, S. torvicornis successfully survived at different scales but in second and third layers only . The highest level of survivorship was found in A. salina cysts. In preliminary land experiments that imitated land EXPOSE imitation of outside space station UV and vacuum conditions survivorship in resting eggs of D .magna, S. torvicornis and E. ornate was tested also. The total UV dose of

Regional assessment of urban impacts on landcover and open space finds a smart urban growth policy performs little better than business as usual.

Science.gov (United States)

Thorne, James H; Santos, Maria J; Bjorkman, Jacquelyn H

2013-01-01

Assessment of landscape change is critical for attainment of regional sustainability goals. Urban growth assessments are needed because over half the global population now lives in cities, which impact biodiversity, ecosystem structure and ecological processes. Open space protection is needed to preserve these attributes, and provide the resources humans need. The San Francisco Bay Area, California, is challenged to accommodate a population increase of 3.07 million while maintaining the region's ecosystems and biodiversity. Our analysis of 9275 km² in the Bay Area links historic trends for three measures: urban growth, protected open space, and landcover types over the last 70 years to future 2050 projections of urban growth and open space. Protected open space totaled 348 km² (3.7% of the area) in 1940, and expanded to 2221 km² (20.2%) currently. An additional 1038 km² of protected open space is targeted (35.1%). Urban area historically increased from 396.5 km² to 2239 km² (24.1% of the area). Urban growth during this time mostly occurred at the expense of agricultural landscapes (62.9%) rather than natural vegetation. Smart Growth development has been advanced as a preferred alternative in many planning circles, but we found that it conserved only marginally more open space than Business-as-usual when using an urban growth model to portray policies for future urban growth. Scenarios to 2050 suggest urban development on non-urban lands of 1091, 956, or 179 km², under Business-as-usual, Smart Growth and Infill policy growth scenarios, respectively. The Smart Growth policy converts 88% of natural lands and agriculture used by Business-as-usual, while Infill used only 40% of those lands. Given the historic rate of urban growth, 0.25%/year, and limited space available, the Infill scenario is recommended. While the data may differ, the use of an historic and future framework to track these three variables can be easily applied to other metropolitan areas.

Photon Pressure Force on Space Debris TOPEX/Poseidon Measured by Satellite Laser Ranging

Science.gov (United States)

Kucharski, D.; Kirchner, G.; Bennett, J. C.; Lachut, M.; Sośnica, K.; Koshkin, N.; Shakun, L.; Koidl, F.; Steindorfer, M.; Wang, P.; Fan, C.; Han, X.; Grunwaldt, L.; Wilkinson, M.; Rodríguez, J.; Bianco, G.; Vespe, F.; Catalán, M.; Salmins, K.; del Pino, J. R.; Lim, H.-C.; Park, E.; Moore, C.; Lejba, P.; Suchodolski, T.

2017-10-01

The (TOPography EXperiment) TOPEX/Poseidon (T/P) altimetry mission operated for 13 years before the satellite was decommissioned in January 2006, becoming a large space debris object at an altitude of 1,340 km. Since the end of the mission, the interaction of T/P with the space environment has driven the satellite's spin dynamics. Satellite laser ranging (SLR) measurements collected from June 2014 to October 2016 allow for the satellite spin axis orientation to be determined with an accuracy of 1.7°. The spin axis coincides with the platform yaw axis (formerly pointing in the nadir direction) about which the body rotates in a counterclockwise direction. The combined photometric and SLR data collected over the 11 year time span indicates that T/P has continuously gained rotational energy at an average rate of 2.87 J/d and spins with a period of 10.73 s as of 19 October 2016. The satellite attitude model shows a variation of the cross-sectional area in the Sun direction between 8.2 m2 and 34 m2. The direct solar radiation pressure is the main factor responsible for the spin-up of the body, and the exerted photon force varies from 65 μN to 228 μN around the mean value of 138.6 μN. Including realistic surface force modeling in orbit propagation algorithms will improve the prediction accuracy, giving better conjunction warnings for scenarios like the recent close approach reported by the ILRS Space Debris Study Group—an approximate 400 m flyby between T/P and Jason-2 on 20 June 2017.

Comparative investigations of tablet crushing force testers

DEFF Research Database (Denmark)

Sonnergaard, Jørn; Jensen, C.G.; Poulsen, L.

2005-01-01

The performance of 16 tablet breaking force testers was evaluated in terms of accuracy, reproducibility and repeatability. Three tablet formulations with different plastic or brittle deformation mechanisms and with target breaking forces of 50, 100 and 150 N were tested. Statistically significant...... by the concept of components of variance was 5-7 % depending on the model tablet excipient. The standard deviation within testers (repeatability) was affected by the type of model formulation showing increasing variability with increasing brittleness of the compressed material. No specific effect of altering...

The effect of different environmental factors on force degradation of three common systems of orthodontic space closure.

Science.gov (United States)

Oshagh, Morteza; Khajeh, Farzaneh; Heidari, Somayeh; Torkan, Sepideh; Fattahi, Hamid Reza

2015-01-01

Different environmental conditions, such as high temperature or exposure to some chemical agents, may affect the force decay of different methods of space closure during orthodontic treatment. The aim of this in vitro study was to evaluate the force decay pattern in the presence of tea as a popular drink in some parts of the world and two mouthwashes that are usually prescribed by the orthodontist once the treatment is in progress. Elastic chain (EC), nickel-titanium (Ni-Ti) closed coil spring and tie-back (TB) method were used as the means of space closure. The specimens were placed in five different media: Hot tea, hot water (65°), chlorhexidine mouthwash, fluoride mouthwash and the control group (water at 37°). The specimens were stretched 25 mm and the elastic force of three systems was measured at the beginning of the study, after 24 h, after 1 week and after 3 weeks. One-way ANOVA was used to compare the results between the groups and Duncan test was carried out to compare the sets of means in different groups (P ≤ 0.05). Tea increases the force decay in the EC and TB groups. Oral mouthwashes also resulted in more rapid force decay than the control group. EC and Ni-Ti groups were not much affected in the presence of oral mouthwashes. Regarding the immersion media, TB method showed the biggest variation in different media and Ni-Ti coil spring was least affected by the type of media.

An Experimental Study on the Influence of Soundscapes on People’s Behaviour in an Open Public Space

OpenAIRE

Francesco Aletta; Federica Lepore; Eirini Kostara-Konstantinou; Jian Kang; Arianna Astolfi

2016-01-01

Several studies have investigated how environmental sounds and music can modulate people’s behaviours, particularly in marketing research. However, there are relatively few examples of research about such relationships with a focus on the management of urban public spaces. The current study investigated an open public space used mainly as a pedestrian crossing to analyse the relationship between the audio stimuli and peoples’ behaviours. An experiment relying on covert behavioural observation...

Sensitivity of Space Launch System Buffet Forcing Functions to Buffet Mitigation Options

Science.gov (United States)

Piatak, David J.; Sekula, Martin K.; Rausch, Russ D.

2016-01-01

Time-varying buffet forcing functions arise from unsteady aerodynamic pressures and are one of many load environments, which contribute to the overall loading condition of a launch vehicle during ascent through the atmosphere. The buffet environment is typically highest at transonic conditions and can excite the vehicle dynamic modes of vibration. The vehicle response to these buffet forcing functions may cause high structural bending moments and vibratory environments, which can exceed the capabilities of the structure, or of vehicle components such as payloads and avionics. Vehicle configurations, protuberances, payload fairings, and large changes in stage diameter can trigger undesirable buffet environments. The Space Launch System (SLS) multi-body configuration and its structural dynamic characteristics presented challenges to the load cycle design process with respect to buffet-induced loads and responses. An initial wind-tunnel test of a 3-percent scale SLS rigid buffet model was conducted in 2012 and revealed high buffet environments behind the booster forward attachment protuberance, which contributed to reduced vehicle structural margins. Six buffet mitigation options were explored to alleviate the high buffet environments including modified booster nose cones and fences/strakes on the booster and core. These studies led to a second buffet test program that was conducted in 2014 to assess the ability of the buffet mitigation options to reduce buffet environments on the vehicle. This paper will present comparisons of buffet forcing functions from each of the buffet mitigation options tested, with a focus on sectional forcing function rms levels within regions of the vehicle prone to high buffet environments.

Urban open spaces: the relationship of uses within the neighborhood scale

Directory of Open Access Journals (Sweden)

Wilza Gomes Reis Lopes

2007-06-01

Full Text Available In the urban habitacionais areas the population needs areas with which they can be identified, of free spaces that reflect the identity of its inhabitants. Thus, the square is had as public good of the cities, opened to all and endowed with functions, that supply the physical and mental necessities of its inhabitants. This work had as objective to present the diverse joined uses and the way as the users if they appropriate of the squares in the Mocambinho quarter located in the zone north of the city of Teresina, its Inter-relations in the context where they are inserted.

In silico reversal of repeat-induced point mutation (RIP identifies the origins of repeat families and uncovers obscured duplicated genes

Directory of Open Access Journals (Sweden)

Hane James K

2010-11-01

Full Text Available Abstract Background Repeat-induced point mutation (RIP is a fungal genome defence mechanism guarding against transposon invasion. RIP mutates the sequence of repeated DNA and over time renders the affected regions unrecognisable by similarity search tools such as BLAST. Results DeRIP is a new software tool developed to predict the original sequence of a RIP-mutated region prior to the occurrence of RIP. In this study, we apply deRIP to the genome of the wheat pathogen Stagonospora nodorum SN15 and predict the origin of several previously uncharacterised classes of repetitive DNA. Conclusions Five new classes of transposon repeats and four classes of endogenous gene repeats were identified after deRIP. The deRIP process is a new tool for fungal genomics that facilitates the identification and understanding of the role and origin of fungal repetitive DNA. DeRIP is open-source and is available as part of the RIPCAL suite at http://www.sourceforge.net/projects/ripcal.

An Experimental Study on the Influence of Soundscapes on People’s Behaviour in an Open Public Space

OpenAIRE

Aletta, F.; Lepore, F.; Kostara-Konstantinou, E.; Kang, J.; Astolfi, A.

2016-01-01

Several studies have investigated how environmental sounds and music can modulate\\ud people’s behaviours, particularly in marketing research. However, there are relatively few examples\\ud of research about such relationships with a focus on the management of urban public spaces.\\ud The current study investigated an open public space used mainly as a pedestrian crossing to analyse\\ud the relationship between the audio stimuli and peoples’ behaviours. An experiment relying on\\ud covert behaviou...

The impact of urban open space and 'lift-up' building design on building intake fraction and daily pollutant exposure in idealized urban models.

Science.gov (United States)

Sha, Chenyuan; Wang, Xuemei; Lin, Yuanyuan; Fan, Yifan; Chen, Xi; Hang, Jian

2018-08-15

Sustainable urban design is an effective way to improve urban ventilation and reduce vehicular pollutant exposure to urban residents. This paper investigated the impacts of urban open space and 'lift-up' building design on vehicular CO (carbon monoxide) exposure in typical three-dimensional (3D) urban canopy layer (UCL) models under neutral atmospheric conditions. The building intake fraction (IF) represents the fraction of total vehicular pollutant emissions inhaled by residents when they stay at home. The building daily CO exposure (E t ) means the extent of human beings' contact with CO within one day indoor at home. Computational fluid dynamics (CFD) simulations integrating with these two concepts were performed to solve turbulent flow and assess vehicular CO exposure to urban residents. CFD technique with the standard k-ε model was successfully validated by wind tunnel data. The initial numerical UCL model consists of 5-row and 5-column (5×5) cubic buildings (building height H=street width W=30m) with four approaching wind directions (θ=0°, 15°, 30°, 45°). In Group I, one of the 25 building models is removed to attain urban open space settings. In Group II, the first floor (Lift-up1), or second floor (Lift-up2), or third floor (Lift-up3) of all buildings is elevated respectively to create wind pathways through buildings. Compared to the initial case, urban open space can slightly or significantly reduce pollutant exposure for urban residents. As θ=30° and 45°, open space settings are more effective to reduce pollutant exposure than θ=0° and 15°.The pollutant dilution near or surrounding open space and in its adjacent downstream regions is usually enhanced. Lift-up1 and Lift-up2 experience much greater pollutant exposure reduction in all wind directions than Lift-up3 and open space. Although further investigations are still required to provide practical guidelines, this study is one of the first attempts for reducing urban pollutant exposure by

Upper Incisor Changes Due to Modifying the Point of Application of Forces during Space Closure in MBT Technique

Directory of Open Access Journals (Sweden)

H. Ravanmehr

2004-06-01

Full Text Available Statement of Problem: A recent technique (MBT has been introduced for easy and efficient orthodontic treatment by means of straight wire fixed appliances. Although this technique has many advantages, in space closure stage causes up righting problem in upper incisors, which should be adjusted by applying additional torque in anterior region.Purpose: The purpose of this clinical trial was to determine whether there is a significant difference in final incisor inclination (torque of two groups one treated with MBT technique and the other by changing the point of application of the closing force (in anterior region.Materials and Methods: Twelve patients (8 girls, 4 boys with Cl I malocclusion and crowding, whom were candidate for first premolars extraction, were selected.For space closure, 6 anterior teeth (canine to canine in upper and lower jaws ligated and the applied force was from the hooks on canines to hooks on the first molars.After space closure the results compared with the results of a previous study which treatment plan was according to original MBT technique (anterior hooks soldered to arch wire. Forces applied randomly among quadrants by NiTi coil spring (American Orthodontics Co. or active tie backs with elastic modules (Dentaurum Co.Results: The results showed a statistically significant difference between final torques of two techniques (P=0.0001. Also, the rate of space closure with NiTi coils was significantly greater than active tie back (P=0.0001.Conclusion: Anchorage loss in two groups compared and the results indicated significantly lower anchorage loss in NiTi coil spring group (P=0.035.

Supporting Air and Space Expeditionary Forces. Capabilities and Sustainability of Air and Space Expeditionary Forces

National Research Council Canada - National Science Library

Snyder, Don; Mills, Patrick; Carrillo, Manuel; Resnick, Adam

2006-01-01

The Department of Defense in recent years has shifted from a focus on sizing and shaping its forces to meet specific war plans to policies based on capabilities that can be directed toward a spectrum of missions...

Keynote speech - Manned Space Flights: Lessons Learned from Space Craft Operation and Maintenance

CERN Multimedia

CERN. Geneva

2013-01-01

Following graduation in 1973 from the Ecole de l'Air (the French Air Force Academy), Michel Tognini served in the French Air Force as an operational fighter pilot, flight leader in 1976, flight commander in 1979, test pilot then chief test pilot from 1983 to 1985. In 1985, France opened a recruitment program to expand its astronaut corps, and Michel Tognini was one of seven candidates selected by CNES. In July 1986, he was one of four candidates to undergo medical examinations in Moscow. In August 1986, he was assigned as a back-up crew member for the Soyuz TM-7 mission. Although he remained a French Air Force officer, he was placed on detachment to CNES for his space flight activities from September 1986 onwards. In 1991 he went to Star City, Russia, to start prime crew training for the third Soviet-French ANTARES mission. During his stay in Russia, he linked up with Mir (ANTARES mission) and spent 14 days (July 27–Aug. 10, 1992; Soyuz TM-14 and TM-14)carrying out a program of joint Soviet-French experimen...

Bayesian inverse problems in measure spaces with application to Burgers and Hamilton–Jacobi equations with white noise forcing

International Nuclear Information System (INIS)

Hoang, Viet Ha

2012-01-01

This paper formulates Bayesian inverse problems for inference in a topological measure space given noisy observations. Conditions for the validity of the Bayes’ formula and the well posedness of the posterior measure are studied. The abstract theory is then applied to Burgers and Hamilton–Jacobi equations on a semi-infinite time interval with forcing functions which are white noise in time. Inference is made on the white noise forcing, assuming the Wiener measure as the prior. (paper)

Socializing in an open drug scene: the relationship between access to private space and drug-related street disorder.

Science.gov (United States)

Debeck, Kora; Wood, Evan; Qi, Jiezhi; Fu, Eric; McArthur, Doug; Montaner, Julio; Kerr, Thomas

2012-01-01

Limited attention has been given to the potential role that the structure of housing available to people who are entrenched in street-based drug scenes may play in influencing the amount of time injection drug users (IDU) spend on public streets. We sought to examine the relationship between time spent socializing in Vancouver's drug scene and access to private space. Using multivariate logistic regression we evaluated factors associated with socializing (three+ hours each day) in Vancouver's open drug scene among a prospective cohort of IDU. We also assessed attitudes towards relocating socializing activities if greater access to private indoor space was provided. Among our sample of 1114 IDU, 43% fit our criteria for socializing in the open drug scene. In multivariate analysis, having limited access to private space was independently associated with socializing (adjusted odds ratio: 1.80, 95% confidence interval: 1.28-2.55). In further analysis, 65% of 'socializers' reported positive attitudes towards relocating socializing if they had greater access to private space. These findings suggest that providing IDU with greater access to private indoor space may reduce one component of drug-related street disorder. Low-threshold supportive housing based on the 'housing first' model that include safeguards to manage behaviors associated with illicit drug use appear to offer important opportunities to create the types of private spaces that could support a reduction in street disorder. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Quantum mechanics on the moduli space from the quantum geometrodynamics of the open topological membrane

International Nuclear Information System (INIS)

Kogan, I.I.

1991-01-01

The quantum geometrodynamics of the open topological membrane is described in terms of 2+1 topologically massive gravity (TMG) where the inverse graviton mass is proportional to the 2D central charge and thus is the measure of the off-criticality. The hamiltonian quantization of TMG on Riemann surfaces is considered and the moduli space appears as the subspace of the quantum-mechanical configuration space containing, besides the moduli, the first-order time derivatives of half of the moduli. The appearance of the first-order time derivatives as coordinates, not momenta, is due to the third-order derivative in the TMG lagrangian. The hamiltonian for the latter leads us to the discrete levels picture which looks like the topologically massive gauge theory (TMGT) case, where we also get the Landau levels picture and the lowest Landau level corresponds to the Hilbert space of the Chern-Simons theory (CST). The connection between the positivity of the energy and the complex structure on the moduli space is discussed. (orig.)

Evaluation of the flow forces on an open centre directional control valve by means of a computational fluid dynamic analysis

International Nuclear Information System (INIS)

Amirante, R.; Del Vescovo, G.; Lippolis, A.

2006-01-01

The aim of the present paper is the evaluation of the driving forces acting on a 4/3 hydraulic open center directional control valve spool by means of a complete numerical analysis. In a previous paper by the same authors, the valve was inserted in a closed hydraulic circuit and was tested with different pump flow rate values to obtain experimental results about the driving forces. The experimental results are used in this paper to evaluate and validate the numerical analysis of the valve. The obtained numerical results show important differences between an open center valve and a closed center one, the latter being extensively analyzed in the literature. The numerical analysis is performed by using the commercial code 'Fluent', and the numerical results show the complete flow field inside the valve. The aim of this analysis is to evaluate the valve fluid dynamic performance, exploiting computational fluid dynamics (CFD) techniques, in order to give the reliable indications needed to define the valve design criteria and avoid expensive experimental tests

An open-loop system design for deep space signal processing applications

Science.gov (United States)

Tang, Jifei; Xia, Lanhua; Mahapatra, Rabi

2018-06-01

A novel open-loop system design with high performance is proposed for space positioning and navigation signal processing. Divided by functions, the system has four modules, bandwidth selectable data recorder, narrowband signal analyzer, time-delay difference of arrival estimator and ANFIS supplement processor. A hardware-software co-design approach is made to accelerate computing capability and improve system efficiency. Embedded with the proposed signal processing algorithms, the designed system is capable of handling tasks with high accuracy over long period of continuous measurements. The experiment results show the Doppler frequency tracking root mean square error during 3 h observation is 0.0128 Hz, while the TDOA residue analysis in correlation power spectrum is 0.1166 rad.

Soft ideal topological space and mixed fuzzy soft ideal topological space

Directory of Open Access Journals (Sweden)

Manash Borah

2019-01-01

Full Text Available In this paper we introduce fuzzy soft ideal and mixed fuzzy soft ideal topological spaces and some properties of this space. Also we introduce fuzzy soft $I$-open set, fuzzy soft $\\alpha$-$I$-open set, fuzzy soft pre-$I$-open set, fuzzy soft semi-$I$-open set and fuzzy soft $\\beta$-$I$-open set and discuss some of their properties.

Modeling forces in high-temperature superconductors

International Nuclear Information System (INIS)

Turner, L. R.; Foster, M. W.

1997-01-01

We have developed a simple model that uses computed shielding currents to determine the forces acting on a high-temperature superconductor (HTS). The model has been applied to measurements of the force between HTS and permanent magnets (PM). Results show the expected hysteretic variation of force as the HTS moves first toward and then away from a permanent magnet, including the reversal of the sign of the force. Optimization of the shielding currents is carried out through a simulated annealing algorithm in a C++ program that repeatedly calls a commercial electromagnetic software code. Agreement with measured forces is encouraging

Open Data and Open Science for better Research in the Geo and Space Domain

Science.gov (United States)

Ritschel, B.; Seelus, C.; Neher, G.; Iyemori, T.; Koyama, Y.; Yatagai, A. I.; Murayama, Y.; King, T. A.; Hughes, S.; Fung, S. F.; Galkin, I. A.; Hapgood, M. A.; Belehaki, A.

2015-12-01

Main open data principles had been worked out in the run-up and finally adopted in the Open Data Charta at the G8 summit in Lough Erne, Northern Ireland in June 2013. Important principles are also valid for science data, such as Open Data by Default, Quality and Quantity, Useable by All, Releasing Data for Improved Governance, Releasing Data for Innovation. There is also an explicit relationship to such areas of high values as earth observation, education and geospatial data. The European union implementation plan of the Open Data Charta identifies among other things objectives such as making data available in an open format, enabling semantic interoperability, ensuring quality, documentation and where appropriate reconciliation across different data sources, implementing software solutionsallowing easy management, publication or visualization of datasets and simplifying clearance of intellectual property rights.Open Science is not just a list of already for a longer time known principles but stands for a lot of initiatives and projects around a better handling of scientific data and openly shared scientific knowledge. It is also about transparency in methodology and collection of data, availability and reuse of scientific data, public accessibility to scientific communication and using of social media to facility scientific collaboration. Some projects are concentrating on open sharing of free and open source software and even further hardware in kind of processing capabilities. In addition question about the mashup of data and publication and an open peer review process are addressed.Following the principles of open data and open science the newest results of the collaboration efforts in mashing up the data servers related to the Japanese IUGONET, the European Union ESPAS and the GFZ ISDC semantic Web projects will be presented here. The semantic Web based approach for the mashup is focusing on the design and implementation of a common but still distributed data

The Spaces of Open-Source Politics

DEFF Research Database (Denmark)

Husted, Emil; Plesner, Ursula

The recent proliferation of Web 2.0 technologies and their role in contemporary political life has inspired the coining of the term ‘open-source politics’. This article analyzes how open-source politics is organized in the case of a young radical political party called The Alternative. Inspired...... processes, but may provide both closure and disconnection between the party’s universal body and its particular body. In conclusion, we propose that such a disconnection might be a precondition for success when institutionalizing radical politics, as it allows parties like The Alternative to maintain...

Implementation of an Open-Scenario, Long-Term Space Debris Simulation Approach

Science.gov (United States)

Nelson, Bron; Yang Yang, Fan; Carlino, Roberto; Dono Perez, Andres; Faber, Nicolas; Henze, Chris; Karacalioglu, Arif Goktug; O'Toole, Conor; Swenson, Jason; Stupl, Jan

2015-01-01

This paper provides a status update on the implementation of a flexible, long-term space debris simulation approach. The motivation is to build a tool that can assess the long-term impact of various options for debris-remediation, including the LightForce space debris collision avoidance concept that diverts objects using photon pressure [9]. State-of-the-art simulation approaches that assess the long-term development of the debris environment use either completely statistical approaches, or they rely on large time steps on the order of several days if they simulate the positions of single objects over time. They cannot be easily adapted to investigate the impact of specific collision avoidance schemes or de-orbit schemes, because the efficiency of a collision avoidance maneuver can depend on various input parameters, including ground station positions and orbital and physical parameters of the objects involved in close encounters (conjunctions). Furthermore, maneuvers take place on timescales much smaller than days. For example, LightForce only changes the orbit of a certain object (aiming to reduce the probability of collision), but it does not remove entire objects or groups of objects. In the same sense, it is also not straightforward to compare specific de-orbit methods in regard to potential collision risks during a de-orbit maneuver. To gain flexibility in assessing interactions with objects, we implement a simulation that includes every tracked space object in Low Earth Orbit (LEO) and propagates all objects with high precision and variable time-steps as small as one second. It allows the assessment of the (potential) impact of physical or orbital changes to any object. The final goal is to employ a Monte Carlo approach to assess the debris evolution during the simulation time-frame of 100 years and to compare a baseline scenario to debris remediation scenarios or other scenarios of interest. To populate the initial simulation, we use the entire space

Nucleonics, and nuclear matter in 10-20 secs. before the close of open-quotes Big Bangclose quotes

International Nuclear Information System (INIS)

Ayub, S.M.

1995-01-01

The Nuclear picture 10 -20 secs. after the thermonuclear creation of the Universe ∼8 Billion years ago (as also evidenced by Hubble Telescope) was published. Relativity concepts predict the Nuclear picture l0 -20 secs. before the open-quote G close-quote collapse of the Universe, by the progressive decline of expansion,and H. Constant. No double-nuclei, anymore. Only Neutrinos, as predicted by International Scientists, and fragments of Black Holes. Universe open-quote r close-quote=60 Billion Light-Years. At the Zero Point, N.Force,and 3 other Forces merging into Super-G. Time, Space, becoming identical, and all Physical Laws vanishing. The final will be Nuclear Matter compact of ∼ 10Km., open-quote r close-quote, P=10 15 -10 18 Temp. > 10 10 Deg. C. P> 10 18 will cause another thermonuclear Bang'. Super-computers, also, cannot predict beyond this point. There will be the Creator, and a compact of Nuclear Matter. In the absence of Physical Laws, there can be no further predictability. What initiated by the N. Force, has culminated into a compact of Nuclear Matter- - how interesting exclamation point

Air Force electrochemical power research and technology program for space applications

Science.gov (United States)

Allen, Douglas

1987-01-01

An overview is presented of the existing Air Force electrochemical power, battery, and fuel cell programs for space application. Present thrusts are described along with anticipated technology availability dates. Critical problems to be solved before system applications occur are highlighted. Areas of needed performance improvement of batteries and fuel cells presently used are outlined including target dates for key demonstrations of advanced technology. Anticipated performance and current schedules for present technology programs are reviewed. Programs that support conventional military satellite power systems and special high power applications are reviewed. Battery types include bipolar lead-acid, nickel-cadmium, silver-zinc, nickel-hydrogen, sodium-sulfur, and some candidate advanced couples. Fuel cells for pulsed and transportation power applications are discussed as are some candidate advanced regenerative concepts.

CETF Space Station payload pointing system design and analysis feasibility study. [Critical Evaluation Task Force

Science.gov (United States)

Smagala, Tom; Mcglew, Dave

1988-01-01

The expected pointing performance of an attached payload coupled to the Critical Evaluation Task Force Space Station via a payload pointing system (PPS) is determined. The PPS is a 3-axis gimbal which provides the capability for maintaining inertial pointing of a payload in the presence of disturbances associated with the Space Station environment. A system where the axes of rotation were offset from the payload center of mass (CM) by 10 in. in the Z axis was studied as well as a system having the payload CM offset by only 1 inch. There is a significant improvement in pointing performance when going from the 10 in. to the 1 in. gimbal offset.

Compound list: hexachlorobenzene [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available hexachlorobenzene HCB 00022 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/...Human/in_vitro/hexachlorobenzene.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LA...TEST/Rat/in_vitro/hexachlorobenzene.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/L...ATEST/Rat/in_vivo/Liver/Single/hexachlorobenzene.Rat.in_vivo.Liver.Single.zip ftp...://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/hexachlorobenzene.Rat.in_vivo.L

Compound list: cyclophosphamide [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available cyclophosphamide CPA 00024 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/H...uman/in_vitro/cyclophosphamide.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATE...ST/Rat/in_vitro/cyclophosphamide.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATE...ST/Rat/in_vivo/Liver/Single/cyclophosphamide.Rat.in_vivo.Liver.Single.zip ftp://f...tp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/cyclophosphamide.Rat.in_vivo.Liver.

Compound list: bromoethylamine [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available bromoethylamine BEA 00134 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/bromoethylam...ine.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST...Rat/in_vivo/Liver/Single/bromoethylamine.Rat.in_vivo.Liver.Single.zip ftp://ftp.b...iosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/bromoethylamine.Rat.in_vivo.Liver.Repea...t.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Kidney/Single/bromoethylamine.Rat.i

Hybrid FRC under repeated loading

International Nuclear Information System (INIS)

Komlos, K.; Babal, B.; Nuernbergerova, T.

1993-01-01

Fibre reinforced concretes (FRC) containing several volume fractions in different ratios of two types of fibres - polypropylene and steel, were tested under repeated loading. Mechanical properties of specimens - cubes 150/150/150 mm (for compressive strength), prisms 100/100/400 (for flexural strength), short cylinders 150/60 mm (for impact strength) have been experimentally investigated before and after cyclic loading at the age of 28 days curing time. Mix proportions were designed after DIN 1045 with max. aggregate size 8 mm and grading curve B 8. Portland Cement PC 400 in the amount of 450 kg. m -3 was applied and W/C ratio 0.55. Workability of mixes was measured by Vebe method and regulated by plasticizing admixture Ligoplast Na. Maximum hybrid fibre volume fraction (polypropylene + steel) was 1.0%. Dynamic forces generated in Schenck testing machine with frequency 16 Hz had sinusoidal wave form varying between 0.7 and 0.1 of static mechanical characteristics. The number of cycles in all tests was 10 5 . The residual MOR at static four point bending test and working diagram force-deflection was carried out as well. The impact properties after repeated loading in compression were tested by means of falling weight test. Relationships between composition of fibre composites with different combination of polypropylene (0.2, 0.3, 0.5% by volume) and steel (0.5, 0.7, and 0.8% by volume) fibre content were obtained and technological properties of mixes as well. (author)

The Alexandria library, a quantum-chemical database of molecular properties for force field development.

Science.gov (United States)

Ghahremanpour, Mohammad M; van Maaren, Paul J; van der Spoel, David

2018-04-10

Data quality as well as library size are crucial issues for force field development. In order to predict molecular properties in a large chemical space, the foundation to build force fields on needs to encompass a large variety of chemical compounds. The tabulated molecular physicochemical properties also need to be accurate. Due to the limited transparency in data used for development of existing force fields it is hard to establish data quality and reusability is low. This paper presents the Alexandria library as an open and freely accessible database of optimized molecular geometries, frequencies, electrostatic moments up to the hexadecupole, electrostatic potential, polarizabilities, and thermochemistry, obtained from quantum chemistry calculations for 2704 compounds. Values are tabulated and where available compared to experimental data. This library can assist systematic development and training of empirical force fields for a broad range of molecules.

The Alexandria library, a quantum-chemical database of molecular properties for force field development

Science.gov (United States)

Ghahremanpour, Mohammad M.; van Maaren, Paul J.; van der Spoel, David

2018-04-01

Data quality as well as library size are crucial issues for force field development. In order to predict molecular properties in a large chemical space, the foundation to build force fields on needs to encompass a large variety of chemical compounds. The tabulated molecular physicochemical properties also need to be accurate. Due to the limited transparency in data used for development of existing force fields it is hard to establish data quality and reusability is low. This paper presents the Alexandria library as an open and freely accessible database of optimized molecular geometries, frequencies, electrostatic moments up to the hexadecupole, electrostatic potential, polarizabilities, and thermochemistry, obtained from quantum chemistry calculations for 2704 compounds. Values are tabulated and where available compared to experimental data. This library can assist systematic development and training of empirical force fields for a broad range of molecules.

DropBot: An open-source digital microfluidic control system with precise control of electrostatic driving force and instantaneous drop velocity measurement

International Nuclear Information System (INIS)

Fobel, Ryan; Fobel, Christian; Wheeler, Aaron R.

2013-01-01

We introduce DropBot: an open-source instrument for digital microfluidics (http://microfluidics.utoronto.ca/dropbot). DropBot features two key functionalities for digital microfluidics: (1) real-time monitoring of instantaneous drop velocity (which we propose is a proxy for resistive forces), and (2) application of constant electrostatic driving forces through compensation for amplifier-loading and device capacitance. We anticipate that this system will enhance insight into failure modes and lead to new strategies for improved device reliability, and will be useful for the growing number of users who are adopting digital microfluidics for automated, miniaturized laboratory operation.

Open string model building

International Nuclear Information System (INIS)

Ishibashi, Nobuyuki; Onogi, Tetsuya

1989-01-01

Consistency conditions of open string theories, which can be a powerful tool in open string model building, are proposed. By making use of these conditions and assuming a simple prescription for the Chan-Paton factors, open string theories in several backgrounds are studied. We show that 1. there exist a large number of consistent bosonic open string theories on Z 2 orbifolds, 2. SO(32) type I superstring is the unique consistent model among fermionic string theories on the ten-dimensional flat Minkowski space, and 3. with our prescription for the Chan-Paton factors, there exist no consistent open superstring theories on (six-dimensional Minkowski space-time) x (Z 2 orbifold). (orig.)

Effect of Repeated Food Morsel Splitting on Jaw Muscle Control

DEFF Research Database (Denmark)

A, Kumar; Svensson, Krister G; Baad-Hansen, Lene

2014-01-01

Mastication is a complex motor task often initiated by splitting of the food morsel between the anterior teeth. Training of complex motor tasks has consistently been shown to trigger neuroplastic changes in corticomotor control and optimization of muscle function. It is not known if training...... and repeated food morsel splitting lead to changes in jaw muscle function. Objective: To investigate if repeated splitting of food morsels in participants with natural dentition changes the force and jaw muscle electromyographic (EMG) activity. Methods: Twenty healthy volunteers (mean age = 26.2 ± 3.9 years......) participated in a single one-hour session divided into six series. Each series consisted of ten trials of a standardized behavioral task (total of 60 trials). The behavioral task was to hold and split a food morsel (8 mm, 180 mg placebo tablet) placed on a bite force transducer with the anterior teeth...

Electromyographic analysis of repeated bouts of eccentric exercise.

Science.gov (United States)

McHugh, M P; Connolly, D A; Eston, R G; Gartman, E J; Gleim, G W

2001-03-01

The repeated bout effect refers to the protective effect provided by a single bout of eccentric exercise against muscle damage from a similar subsequent bout. The aim of this study was to determine if the repeated bout was associated with an increase in motor unit activation relative to force production, an increased recruitment of slow-twitch motor units or increased motor unit synchronization. Surface electromyographic (EMG) signals were recorded from the hamstring muscles during two bouts of submaximal isokinetic (2.6 rad x s(-1)) eccentric (11 men, 9 women) or concentric (6 men, 4 women) contractions separated by 2 weeks. The EMG per unit torque and median frequency were analysed. The initial bout of eccentric exercise resulted in strength loss, pain and muscle tenderness, while the repeated eccentric bout resulted in a slight increase in strength, no pain and no muscle tenderness (bout x time effects, P exercise. The EMG per unit torque and median frequency were not different between the initial and repeated bouts of eccentric exercise. The EMG per unit torque and median frequency increased during both bouts of eccentric exercise (P < 0.01) but did not change during either concentric bout. In conclusion, there was no evidence that the repeated bout effect was due to a neural adaptation.

Evidence of circadian rhythm, oxygen regulation capacity, metabolic repeatability and positive correlations between forced and spontaneous maximal metabolic rates in lake sturgeon Acipenser fulvescens.

Directory of Open Access Journals (Sweden)

Jon C Svendsen

Full Text Available Animal metabolic rate is variable and may be affected by endogenous and exogenous factors, but such relationships remain poorly understood in many primitive fishes, including members of the family Acipenseridae (sturgeons. Using juvenile lake sturgeon (Acipenser fulvescens, the objective of this study was to test four hypotheses: 1 A. fulvescens exhibits a circadian rhythm influencing metabolic rate and behaviour; 2 A. fulvescens has the capacity to regulate metabolic rate when exposed to environmental hypoxia; 3 measurements of forced maximum metabolic rate (MMR(F are repeatable in individual fish; and 4 MMR(F correlates positively with spontaneous maximum metabolic rate (MMR(S. Metabolic rates were measured using intermittent flow respirometry, and a standard chase protocol was employed to elicit MMR(F. Trials lasting 24 h were used to measure standard metabolic rate (SMR and MMR(S. Repeatability and correlations between MMR(F and MMR(S were analyzed using residual body mass corrected values. Results revealed that A. fulvescens exhibit a circadian rhythm in metabolic rate, with metabolism peaking at dawn. SMR was unaffected by hypoxia (30% air saturation (O(2sat, demonstrating oxygen regulation. In contrast, MMR(F was affected by hypoxia and decreased across the range from 100% O(2sat to 70% O(2sat. MMR(F was repeatable in individual fish, and MMR(F correlated positively with MMR(S, but the relationships between MMR(F and MMR(S were only revealed in fish exposed to hypoxia or 24 h constant light (i.e. environmental stressor. Our study provides evidence that the physiology of A. fulvescens is influenced by a circadian rhythm and suggests that A. fulvescens is an oxygen regulator, like most teleost fish. Finally, metabolic repeatability and positive correlations between MMR(F and MMR(S support the conjecture that MMR(F represents a measure of organism performance that could be a target of natural selection.

Mortality of rats under repeated +Gz acceleration in the course of radiation sickness

International Nuclear Information System (INIS)

Rudnicki, T.

1985-01-01

The influence of repeated +10G z acceleration on the mortality of rats after acute total-body irradiation was studied. No conclusive evidence was found to the effect that daily repeated exposures to 5 or 7.5 min of +10G z inertial forces essentially influence the mortality of rats after acute irradiation in the dose range 0.206-0.309 C/kg. 7 refs. (author)

Modular Open System Architecture for Reducing Contamination Risk in the Space and Missile Defense Supply Chain

Science.gov (United States)

Seasly, Elaine

2015-01-01

To combat contamination of physical assets and provide reliable data to decision makers in the space and missile defense community, a modular open system architecture for creation of contamination models and standards is proposed. Predictive tools for quantifying the effects of contamination can be calibrated from NASA data of long-term orbiting assets. This data can then be extrapolated to missile defense predictive models. By utilizing a modular open system architecture, sensitive data can be de-coupled and protected while benefitting from open source data of calibrated models. This system architecture will include modules that will allow the designer to trade the effects of baseline performance against the lifecycle degradation due to contamination while modeling the lifecycle costs of alternative designs. In this way, each member of the supply chain becomes an informed and active participant in managing contamination risk early in the system lifecycle.

Space geodetic observations of repeating slow slip events beneath the Bonin Islands

Science.gov (United States)

Arisa, Deasy; Heki, Kosuke

2017-09-01

The Pacific Plate subducts beneath the Philippine Sea Plate along the Izu-Bonin Trench. We investigated crustal movements at the Bonin Islands, using Global Navigation Satellite System and geodetic Very Long Baseline Interferometry data to reveal how the two plates converge in this subduction zone. These islands are located ∼100 km from the trench, just at the middle between the volcanic arc and the trench, making these islands suitable for detecting signatures of episodic deformation such as slow slip events (SSEs). During 2007-2016, we found five SSEs repeating quasi-periodically with similar displacement patterns. In estimating their fault parameters, we assumed that the fault lies on the prescribed plate boundary, and optimized the size, shape and position of the fault and dislocation vectors. Average fault slip was ∼5 cm, and the average moment magnitude was ∼6.9. We also found one SSE occurred in 2008 updip of the repeating SSE in response to an M6 class interplate earthquake. In spite of the frequent occurrence of SSEs, there is no evidence for long-term strain accumulation in the Bonin Islands that may lead to future megathrust earthquakes. Plate convergence in Mariana-type subduction zones may occur, to a large extent, episodically as repeating SSEs.

Evaluation of Technical and Utility Programmatic Challenges With Residential Forced-Air Integrated Space/Water Heat Systems

Energy Technology Data Exchange (ETDEWEB)

Kingston, Tim [Partnership for Advanced Residential Retrofit, Des Plaines, IL (United States); Vadnal, Hillary [Partnership for Advanced Residential Retrofit, Des Plaines, IL (United States); Scott, Shawn [Partnership for Advanced Residential Retrofit, Des Plaines, IL (United States); Kalensky, Dave [Partnership for Advanced Residential Retrofit, Des Plaines, IL (United States)

2016-12-01

This multi-unit field demonstration of combined space and water heating (combi) systems was conducted to help document combi system installation and performance issues that needed to be addressed through research. The objective of the project was to put commercialized forced-air tankless combi units into the field through local contractors that were trained by manufacturers and GTI staff under the auspices of utility-implemented ETPs.

Force-sensed interface for control and training space robot

Science.gov (United States)

Moiseev, O. S.; Sarsadskikh, A. S.; Povalyaev, N. D.; Gorbunov, V. I.; Kulakov, F. M.; Vasilev, V. V.

2018-05-01

A method of positional and force-torque control of robots is proposed. Prototypes of the system and the master handle have been created. Algorithm of bias estimation and gravity compensation for force-torque sensor and force-torque trajectory correction are described.

Walking Ahead: The Headed Social Force Model.

Directory of Open Access Journals (Sweden)

Francesco Farina

Full Text Available Human motion models are finding an increasing number of novel applications in many different fields, such as building design, computer graphics and robot motion planning. The Social Force Model is one of the most popular alternatives to describe the motion of pedestrians. By resorting to a physical analogy, individuals are assimilated to point-wise particles subject to social forces which drive their dynamics. Such a model implicitly assumes that humans move isotropically. On the contrary, empirical evidence shows that people do have a preferred direction of motion, walking forward most of the time. Lateral motions are observed only in specific circumstances, such as when navigating in overcrowded environments or avoiding unexpected obstacles. In this paper, the Headed Social Force Model is introduced in order to improve the realism of the trajectories generated by the classical Social Force Model. The key feature of the proposed approach is the inclusion of the pedestrians' heading into the dynamic model used to describe the motion of each individual. The force and torque representing the model inputs are computed as suitable functions of the force terms resulting from the traditional Social Force Model. Moreover, a new force contribution is introduced in order to model the behavior of people walking together as a single group. The proposed model features high versatility, being able to reproduce both the unicycle-like trajectories typical of people moving in open spaces and the point-wise motion patterns occurring in high density scenarios. Extensive numerical simulations show an increased regularity of the resulting trajectories and confirm a general improvement of the model realism.

Do features of public open spaces vary according to neighbourhood socio-economic status?

Science.gov (United States)

Crawford, David; Timperio, Anna; Giles-Corti, Billie; Ball, Kylie; Hume, Clare; Roberts, Rebecca; Andrianopoulos, Nick; Salmon, Jo

2008-12-01

This study examined the relations between neighbourhood socio-economic status and features of public open spaces (POS) hypothesised to influence children's physical activity. Data were from the first follow-up of the Children Living in Active Neighbourhoods (CLAN) Study, which involved 540 families of 5-6 and 10-12-year-old children in Melbourne, Australia. The Socio-Economic Index for Areas Index (SEIFA) of Relative Socio-economic Advantage/Disadvantage was used to assign a socioeconomic index score to each child's neighbourhood, based on postcode. Participant addresses were geocoded using a Geographic Information System. The Open Space 2002 spatial data set was used to identify all POS within an 800 m radius of each participant's home. The features of each of these POS (1497) were audited. Variability of POS features was examined across quintiles of neighbourhood SEIFA. Compared with POS in lower socioeconomic neighbourhoods, POS in the highest socioeconomic neighbourhoods had more amenities (e.g. picnic tables and drink fountains) and were more likely to have trees that provided shade, a water feature (e.g. pond, creek), walking and cycling paths, lighting, signage regarding dog access and signage restricting other activities. There were no differences across neighbourhoods in the number of playgrounds or the number of recreation facilities (e.g. number of sports catered for on courts and ovals, the presence of other facilities such as athletics tracks, skateboarding facility and swimming pool). This study suggests that POS in high socioeconomic neighbourhoods possess more features that are likely to promote physical activity amongst children.

Aspects of Cultural Landscape Application on Classical Stage Art. Ballet Performance in the Open Space as a Significant Element of the Cultural Landscape

Directory of Open Access Journals (Sweden)

Jelena Lebedeva

2016-04-01

Full Text Available The article examines the applications aspects of cultural landscape for the preparation of the classical performing arts staging. Research findings highlighted that the cultural landscape (parks, estates, castles, bastions, etc. objects occupies an increasingly important role in public recreation and classical art development programs. At the same time it is noted that event’s aesthetic and emotional quality suffers due to the fact that no specific attention was given for the preparation of the event space. More methodological materials are necessary for preparation of this type of design spaces. In Lithuania classical performing arts events in cultural landscape open spaces are based on XVI–XVII century tradition and has good prospects for modern development. A review of some of the classical art events installations, based on the importance of quality of open spaces influence on the emotional impact, that should be an integral part of the cultural event. The author summarizes his experience of ballet events in open spaces in the cultural landscape – Klaipėda, Trakai. Presented is Tchaikovsky's ballet “Swan Lake” construction in Klaipėda John Hill project that includes infrastructure and environmental design concept: audience space, stage design, stage design performance solutions. Analogous key decisions are later adapted to the ballet performance in the natural environment of the lake Trakai. Experience of this project dictated the necessity of deeper understanding and methodological basis for the classical performing arts analysis and design.

Force delivery of Ni-Ti coil springs.

Science.gov (United States)

Manhartsberger, C; Seidenbusch, W

1996-01-01

Sentalloy springs (GAC, Central Islip, N.Y.) of the open and closed type were investigated with a special designed device. The closed coil springs were subjected to a tensile and the open coil springs to a compression test. After a first measurement, the springs were activated for a period of 4 weeks and then reinvestigated with the same procedure. It could be shown distinctly that, with the different coil springs, the force delivery given by the producer could be achieved only within certain limits. To remain in the martensitic plateau, changed activation ranges, and for the Sentalloy coil springs white and red of the open and closed type, also changed force deliveries had to be taken into account. There was a distinct decrease in force delivery between the first and second measurement. After considering the loading curves of all the Sentalloy coil springs and choosing the right activation range respective to the force delivery, it was found that the coil springs deliver a superior clinical behavior and open new treatment possibilities.

Predicting Multicomponent Adsorption Isotherms in Open-Metal Site Materials Using Force Field Calculations Based on Energy Decomposed Density Functional Theory.

Science.gov (United States)

Heinen, Jurn; Burtch, Nicholas C; Walton, Krista S; Fonseca Guerra, Célia; Dubbeldam, David

2016-12-12

For the design of adsorptive-separation units, knowledge is required of the multicomponent adsorption behavior. Ideal adsorbed solution theory (IAST) breaks down for olefin adsorption in open-metal site (OMS) materials due to non-ideal donor-acceptor interactions. Using a density-function-theory-based energy decomposition scheme, we develop a physically justifiable classical force field that incorporates the missing orbital interactions using an appropriate functional form. Our first-principles derived force field shows greatly improved quantitative agreement with the inflection points, initial uptake, saturation capacity, and enthalpies of adsorption obtained from our in-house adsorption experiments. While IAST fails to make accurate predictions, our improved force field model is able to correctly predict the multicomponent behavior. Our approach is also transferable to other OMS structures, allowing the accurate study of their separation performances for olefins/paraffins and further mixtures involving complex donor-acceptor interactions. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Identification, variation and transcription of pneumococcal repeat sequences

Science.gov (United States)

2011-01-01

Background Small interspersed repeats are commonly found in many bacterial chromosomes. Two families of repeats (BOX and RUP) have previously been identified in the genome of Streptococcus pneumoniae, a nasopharyngeal commensal and respiratory pathogen of humans. However, little is known about the role they play in pneumococcal genetics. Results Analysis of the genome of S. pneumoniae ATCC 700669 revealed the presence of a third repeat family, which we have named SPRITE. All three repeats are present at a reduced density in the genome of the closely related species S. mitis. However, they are almost entirely absent from all other streptococci, although a set of elements related to the pneumococcal BOX repeat was identified in the zoonotic pathogen S. suis. In conjunction with information regarding their distribution within the pneumococcal chromosome, this suggests that it is unlikely that these repeats are specialised sequences performing a particular role for the host, but rather that they constitute parasitic elements. However, comparing insertion sites between pneumococcal sequences indicates that they appear to transpose at a much lower rate than IS elements. Some large BOX elements in S. pneumoniae were found to encode open reading frames on both strands of the genome, whilst another was found to form a composite RNA structure with two T box riboswitches. In multiple cases, such BOX elements were demonstrated as being expressed using directional RNA-seq and RT-PCR. Conclusions BOX, RUP and SPRITE repeats appear to have proliferated extensively throughout the pneumococcal chromosome during the species' past, but novel insertions are currently occurring at a relatively slow rate. Through their extensive secondary structures, they seem likely to affect the expression of genes with which they are co-transcribed. Software for annotation of these repeats is freely available from ftp://ftp.sanger.ac.uk/pub/pathogens/strep_repeats/. PMID:21333003

Belém’s built form and its developments to the formation of a system of open spaces accessible to population

Directory of Open Access Journals (Sweden)

Ana Claudia Duarte Cardoso

2016-07-01

Full Text Available This paper presents a characterization of the built space of Belém highlighting, its estuarine condition, physical geography and its economic, social and spacial development. It is based on Quapá-SEL Workshop conclusions held in Belém, in May 2015, in which teachers and students from São Paulo and Pará Federal Universities assessed the conditions of urban open spaces of the city. The results highlight a disarticulation between real estate agents strategies and of urban management towards structuring an Open Spaces System (SEL in Portuguese, as well as its limited appropriation by the population. There is a remarkable differentiation between the landscapes of central area in opposition / contraposition to that at the city’s expansion area. This debate showed how much permanent preservation areas on the banks of inland rivers and islands (the main green spaces of the city and main linkage with the Amazonian biome, with its landscape potentials, have been unevenly appropriated in the city, through gentrification.

Open Innovation Drug Discovery (OIDD): a potential path to novel therapeutic chemical space.

Science.gov (United States)

Alvim-Gaston, Maria; Grese, Timothy; Mahoui, Abdelaziz; Palkowitz, Alan D; Pineiro-Nunez, Marta; Watson, Ian

2014-01-01

The continued development of computational and synthetic methods has enabled the enumeration or preparation of a nearly endless universe of chemical structures. Nevertheless, the ability of this chemical universe to deliver small molecules that can both modulate biological targets and have drug-like physicochemical properties continues to be a topic of interest to the pharmaceutical industry and academic researchers alike. The chemical space described by public, commercial, in-house and virtual compound collections has been interrogated by multiple approaches including biochemical, cellular and virtual screening, diversity analysis, and in-silico profiling. However, current drugs and known chemical probes derived from these efforts are contained within a remarkably small volume of the predicted chemical space. Access to more diverse classes of chemical scaffolds that maintain the properties relevant for drug discovery is certainly needed to meet the increasing demands for pharmaceutical innovation. The Lilly Open Innovation Drug Discovery platform (OIDD) was designed to tackle barriers to innovation through the identification of novel molecules active in relevant disease biology models. In this article we will discuss several computational approaches towards describing novel, biologically active, drug-like chemical space and illustrate how the OIDD program may facilitate access to previously untapped molecules that may aid in the search for innovative pharmaceuticals.

Feasibility of novel four degrees of freedom capacitive force sensor for skin interface force

Directory of Open Access Journals (Sweden)

Murakami Chisato

2012-11-01

Full Text Available Abstract Background The objective of our study was to develop a novel capacitive force sensor that enables simultaneous measurements of yaw torque around the pressure axis and normal force and shear forces at a single point for the purpose of elucidating pressure ulcer pathogenesis and establishing criteria for selection of cushions and mattresses. Methods Two newly developed sensors (approximately 10 mm×10 mm×5 mm (10 and 20 mm×20 mm×5 mm (20 were constructed from silicone gel and four upper and lower electrodes. The upper and lower electrodes had sixteen combinations that had the function as capacitors of parallel plate type. The full scale (FS ranges of force/torque were defined as 0–1.5 N, –0.5-0.5 N and −1.5-1.5 N mm (10 and 0–8.7 N, –2.9-2.9 N and −16.8-16.8 N mm (20 in normal force, shear forces and yaw torque, respectively. The capacitances of sixteen capacitors were measured by an LCR meter (AC1V, 100 kHz when displacements corresponding to four degrees of freedom (DOF forces within FS ranges were applied to the sensor. The measurement was repeated three times in each displacement condition (10 only. Force/torque were calculated by corrected capacitance and were evaluated by comparison to theoretical values and standard normal force measured by an universal tester. Results In measurements of capacitance, the coefficient of variation was 3.23% (10. The Maximum FS errors of estimated force/torque were less than or equal to 10.1 (10 and 16.4% (20, respectively. The standard normal forces were approximately 1.5 (10 and 9.4 N (20 when pressure displacements were 3 (10 and 2 mm (20, respectively. The estimated normal forces were approximately 1.5 (10 and 8.6 N (10 in the same condition. Conclusions In this study, we developed a new four DOF force sensor for measurement of force/torque that occur between the skin and a mattress. In measurement of capacitance, the repeatability was good and it was confirmed that the sensor had

THE EFFECTS OF SINGLE VERSUS REPEATED PLYOMETRICS ON LANDING BIOMECHANICS AND JUMPING PERFORMANCE IN MEN

Directory of Open Access Journals (Sweden)

H. Makaruk

2014-07-01

Full Text Available The aim of this study was to examine the chronic effects of single and repeated jumps training on vertical landing force (VGRF and jump height in untrained men. The VGRF and jump height were compared after a six-week plyometric training programme containing single and repeated jumps, together with two additional parameters: landing time (LT and range of the knee flexion during landing (KF. Thirty-six untrained physical education students with a plyometric training background were randomly assigned to a single jump group (SJG, n =12, repeated jumps group (RJG, n =12, and control group (CON, n =12. The SJG performed only single jumps, the RJG executed repeated (consecutive jumps, whereas the CON did not perform any exercises at all. A countermovement jump (CMJ, repeated countermovement jumps (RCMJ, and a drop jump (DJ were tested before and after the training. Only the RJG showed a significantly reduced VGRF (p<0.05 in all tests. Both plyometric groups significantly improved (p<0.05 their jump height in all tests. The LT was significantly greater in the RJG, compared to the SJG, in all tests. The KF was also significantly (p<0.05 greater in the RJG than in the SJG for CMJ and RCMJ. The results suggest that repeated jumps are beneficial for simultaneous landing force reduction and jumping performance enhancement.

Magnetic force micropiston: An integrated force/microfluidic device for the application of compressive forces in a confined environment

Science.gov (United States)

Fisher, J. K.; Kleckner, N.

2014-02-01

Cellular biology takes place inside confining spaces. For example, bacteria grow in crevices, red blood cells squeeze through capillaries, and chromosomes replicate inside the nucleus. Frequently, the extent of this confinement varies. Bacteria grow longer and divide, red blood cells move through smaller and smaller passages as they travel to capillary beds, and replication doubles the amount of DNA inside the nucleus. This increase in confinement, either due to a decrease in the available space or an increase in the amount of material contained in a constant volume, has the potential to squeeze and stress objects in ways that may lead to changes in morphology, dynamics, and ultimately biological function. Here, we describe a device developed to probe the interplay between confinement and the mechanical properties of cells and cellular structures, and forces that arise due to changes in a structure's state. In this system, the manipulation of a magnetic bead exerts a compressive force upon a target contained in the confining space of a microfluidic channel. This magnetic force microfluidic piston is constructed in such a way that we can measure (a) target compliance and changes in compliance as induced by changes in buffer, extract, or biochemical composition, (b) target expansion force generated by changes in the same parameters, and (c) the effects of compression stress on a target's structure and function. Beyond these issues, our system has general applicability to a variety of questions requiring the combination of mechanical forces, confinement, and optical imaging.

Repeated Predictable Stress Causes Resilience against Colitis-Induced Behavioral Changes in Mice

Directory of Open Access Journals (Sweden)

Ahmed M Hassan

2014-11-01

Full Text Available Inflammatory bowel disease is associated with an increased risk of mental disorders and can be exacerbated by stress. In this study which was performed with male 10-week old C57Bl/6N mice, we used dextran sulfate sodium (DSS-induced colitis to evaluate behavioral changes caused by intestinal inflammation, to assess the interaction between repeated psychological stress (water avoidance stress, WAS and colitis in modifying behavior, and to analyze neurochemical correlates of this interaction. A 7-day treatment with DSS (2 % in drinking water decreased locomotion and enhanced anxiety-like behavior in the open field test and reduced social interaction. Repeated exposure to WAS for 7 days had little influence on behavior but prevented the DSS-induced behavioral disturbances in the open field and social interaction tests. In contrast, repeated WAS did not modify colon length, colonic myeloperoxidase content and circulating proinflammatory cytokines, parameters used to assess colitis severity. DSS-induced colitis was associated with an increase in circulating neuropeptide Y (NPY, a rise in the hypothalamic expression of cyclooxygenase-2 mRNA and a decrease in the hippocampal expression of NPY mRNA, brain-derived neurotrophic factor mRNA and mineralocorticoid receptor mRNA. Repeated WAS significantly decreased the relative expression of corticotropin-releasing factor mRNA in the hippocampus. The effect of repeated WAS to blunt the DSS-evoked behavioral disturbances was associated with a rise of circulating corticosterone and an increase in the expression of hypothalamic NPY mRNA. These results show that experimental colitis leads to a particular range of behavioral alterations which can be prevented by repeated WAS, a model of predictable chronic stress, while the severity of colitis remains unabated. We conclude that the mechanisms underlying the resilience effect of repeated WAS involves hypothalamic NPY and the hypothalamic-pituitary-adrenal axis.

OpenSubspace

DEFF Research Database (Denmark)

Müller, Emmanuel; Assent, Ira; Günnemann, Stephan

2009-01-01

Subspace clustering and projected clustering are recent research areas for clustering in high dimensional spaces. As the field is rather young, there is a lack of comparative studies on the advantages and disadvantages of the different algorithms. Part of the underlying problem is the lack...... of available open source implementations that could be used by researchers to understand, compare, and extend subspace and projected clustering algorithms. In this paper, we discuss the requirements for open source evaluation software. We propose OpenSubspace, an open source framework that meets...... these requirements. OpenSubspace integrates state-of-the-art performance measures and visualization techniques to foster research in subspace and projected clustering....

Clinical impact of an open-irrigated radiofrequency catheter with direct force measurement on atrial fibrillation ablation.

Science.gov (United States)

Martinek, Martin; Lemes, Christine; Sigmund, Elisabeth; Derndorfer, Michael; Aichinger, Josef; Winter, Siegmund; Nesser, Hans-Joachim; Pürerfellner, Helmut

2012-11-01

Electrode-tissue contact is crucial for adequate lesion formation in radiofrequency catheter ablation (RFCA). We assessed the impact of direct catheter force measurement on acute procedural parameters during RFCA of atrial fibrillation (AF). Fifty consecutive patients (28 male) with paroxysmal AF who underwent their first procedure of circumferential pulmonary vein (PV) isolation (PVI) were assigned to either RFCA using (1) a standard 3.5-mm open-irrigated-tip catheter or (2) a catheter with contact force measurement capabilities. Using the endpoint of PVI with entry and exit block, acute procedural parameters were assessed. Procedural data showed a remarkable decline in ablation time (radiofrequency time needed for PVI) from 50.5 ± 15.9 to 39.0 ± 11.0 minutes (P = 0.007) with a reduction in overall procedure duration from 185 ± 46 to 154 ± 39 minutes (P = 0.022). In parallel, the total energy delivered could be significantly reduced from 70,926 ± 19,470 to 58,511 ± 14,655 Ws (P = 0.019). The number of acute PV reconnections declined from 36% to 12% (P = 0.095). The use of contact force sensing technology is able to significantly reduce ablation and procedure times in PVI. In addition, energy delivery is substantially reduced by avoiding radiofrequency ablation in positions with insufficient surface contact. Procedural efficacy and safety of this new feature have to be evaluated in larger cohorts. ©2012, The Authors. Journal compilation ©2012 Wiley Periodicals, Inc.

Space closure in the maxillary posterior area through the maxillary sinus.

Science.gov (United States)

Park, Jae Hyun; Tai, Kiyoshi; Kanao, Akira; Takagi, Masato

2014-01-01

A common dilemma in adult orthodontic treatment is deciding how best to treat missing posterior teeth. One treatment option is to orthodontically close the space. But closure can be difficult, especially if the open space is in the maxillary posterior area, because tooth movement through the maxillary sinus is limited. The increased difficulty of moving teeth in the maxillary sinus is similar to moving a tooth in the atrophic posterior mandibular ridge. If space closure is selected as a treatment method, proper mechanics and light forces should be applied. In this article, we report movement of teeth through the maxillary sinus and discuss various implications related to orthodontic treatment in the maxillary sinus. Copyright © 2014 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

Nucleonics, and nuclear matter in 10{sup {minus}20} secs. before the close of {open_quotes}Big Bang{close_quotes}

Energy Technology Data Exchange (ETDEWEB)

Ayub, S.M.

1995-10-01

The Nuclear picture 10{sup -20} secs. after the thermonuclear creation of the Universe {approximately}8 Billion years ago (as also evidenced by Hubble Telescope) was published. Relativity concepts predict the Nuclear picture l0{sup -20} secs. before the {open_quote}G{close_quote} collapse of the Universe, by the progressive decline of expansion,and H. Constant. No double-nuclei, anymore. Only Neutrinos, as predicted by International Scientists, and fragments of Black Holes. Universe {open_quote}r{close_quote}=60 Billion Light-Years. At the Zero Point, N.Force,and 3 other Forces merging into Super-G. Time, Space, becoming identical, and all Physical Laws vanishing. The final will be Nuclear Matter compact of {approximately} <13Km.> 10Km., {open_quote}r{close_quote}, P=10{sup 15}-10{sup 18} Temp. > 10{sup 10} Deg. C. P> 10{sup 18} will cause another thermonuclear Bang`. Super-computers, also, cannot predict beyond this point. There will be the Creator, and a compact of Nuclear Matter. In the absence of Physical Laws, there can be no further predictability. What initiated by the N. Force, has culminated into a compact of Nuclear Matter- - how interesting!

NASA/Air Force Cost Model: NAFCOM

Science.gov (United States)

Winn, Sharon D.; Hamcher, John W. (Technical Monitor)

2002-01-01

The NASA/Air Force Cost Model (NAFCOM) is a parametric estimating tool for space hardware. It is based on historical NASA and Air Force space projects and is primarily used in the very early phases of a development project. NAFCOM can be used at the subsystem or component levels.

Experimental identification and analytical modelling of human walking forces: Literature review

Science.gov (United States)

Racic, V.; Pavic, A.; Brownjohn, J. M. W.

2009-09-01

Dynamic forces induced by humans walking change simultaneously in time and space, being random in nature and varying considerably not only between different people but also for a single individual who cannot repeat two identical steps. Since these important aspects of walking forces have not been adequately researched in the past, the corresponding lack of knowledge has reflected badly on the quality of their mathematical models used in vibration assessments of pedestrian structures such as footbridges, staircases and floors. To develop better force models which can be used with more confidence in the structural design, an adequate experimental and analytical approach must be taken to account for their complexity. This paper is the most comprehensive review published to date, of 270 references dealing with different experimental and analytical characterizations of human walking loading. The source of dynamic human-induced forces is in fact in the body motion. To date, human motion has attracted a lot of interest in many scientific branches, particularly in medical and sports science, bioengineering, robotics, and space flight programs. Other fields include biologists of various kinds, physiologists, anthropologists, computer scientists (graphics and animation), human factors and ergonomists, etc. It resulted in technologically advanced tools that can help understanding the human movement in more detail. Therefore, in addition to traditional direct force measurements utilizing a force plate and an instrumented treadmill, this review also introduces methods for indirect measurement of time-varying records of walking forces via combination of visual motion tracking (imaging) data and known body mass distribution. The review is therefore an interdisciplinary article that bridges the gaps between biomechanics of human gait and civil engineering dynamics. Finally, the key reason for undertaking this review is the fact that human-structure dynamic interaction and

Monte Carlo simulation of second-generation open-type PET ''single-ring OpenPET'' implemented with DOI detectors

International Nuclear Information System (INIS)

Tashima, Hideaki; Yamaya, Taiga; Hirano, Yoshiyuki; Yoshida, Eiji; Kinouch, Shoko; Watanabe, Mitsuo; Tanaka, Eiichi

2013-01-01

At the National Institute of Radiological Sciences, we are developing OpenPET, an open-type positron emission tomography (PET) geometry with a physically open space, which allows easy access to the patient during PET studies. Our first-generation OpenPET system, dual-ring OpenPET, which consisted of two detector rings, could provide an extended axial field of view (FOV) including the open space. However, for applications such as in-beam PET to monitor the dose distribution in situ during particle therapy, higher sensitivity concentrated on the irradiation field is required rather than a wide FOV. In this report, we propose a second-generation OpenPET geometry, single-ring OpenPET, which can efficiently improve sensitivity while providing the required open space. When the proposed geometry was realized with block detectors, position-dependent degradation of the spatial resolution was expected because it was necessary to arrange the detector blocks in ellipsoidal rings stacked and shifted relative to one another. However, we found by Monte Carlo simulation that the use of depth-of-interaction (DOI) detectors made it feasible to achieve uniform spatial resolution in the FOV. (author)

Influence of Music on the Behaviors of Crowd in Urban Open Public Spaces.

Science.gov (United States)

Meng, Qi; Zhao, Tingting; Kang, Jian

2018-01-01

Sound environment plays an important role in urban open spaces, yet studies on the effects of perception of the sound environment on crowd behaviors have been limited. The aim of this study, therefore, is to explore how music, which is considered an important soundscape element, affects crowd behaviors in urban open spaces. On-site observations were performed at a 100 m × 70 m urban leisure square in Harbin, China. Typical music was used to study the effects of perception of the sound environment on crowd behaviors; then, these behaviors were classified into movement (passing by and walking around) and non-movement behaviors (sitting). The results show that the path of passing by in an urban leisure square with music was more centralized than without music. Without music, 8.3% of people passing by walked near the edge of the square, whereas with music, this percentage was zero. In terms of the speed of passing by behavior, no significant difference was observed with the presence or absence of background music. Regarding the effect of music on walking around behavior in the square, the mean area and perimeter when background music was played were smaller than without background music. The mean speed of those exhibiting walking around behavior with background music in the square was 0.296 m/s slower than when no background music was played. For those exhibiting sitting behavior, when background music was not present, crowd density showed no variation based on the distance from the sound source. When music was present, it was observed that as the distance from the sound source increased, crowd density of those sitting behavior decreased accordingly.

Forcing absoluteness and regularity properties

NARCIS (Netherlands)

Ikegami, D.

2010-01-01

For a large natural class of forcing notions, we prove general equivalence theorems between forcing absoluteness statements, regularity properties, and transcendence properties over L and the core model K. We use our results to answer open questions from set theory of the reals.

Results of repeated antireflux operations on hiatal hernias

Directory of Open Access Journals (Sweden)

Khubolov A.M.

2016-06-01

Full Text Available The research goal: to carry out the retrospective analysis of results of repeated antireflux interventions at the recurrent hernias of an esophageal opening of a diaphragm (HEOD. Material and methods. Results of surgical treatment of 38 patients with recurrence of HEOD in various terms after operation are studied. Results. At the most part of patients at repeated operations anatomic prerequisites to formation of recurrence of HEOD — migration of a fundoplication cuff, insolvency, an excessive tension of tissues when forming the gastric coupling, violation of technology of imposing of a cuff come to light. In this regard, proceeding from these references and the analysis of own research, it has been considered that plasticity of local tissues at recurrent HEOD, is insufficient for reliable elimination of a gastroesopha-geal reflux. Conclusion. The analysis of the results of antireflux surgical treatment of HEOD with a reflux-esophageal phenomenon has shown high efficiency of no tension plasticity, with use of a synthetic artificial limb. The fundoplication technique in antireflux surgery with no tension plasticity may be used as an operation of choice at recurrent hernias of an esophageal opening of a diaphragm.

A comparison of force sensing techniques for planetary manipulation

Science.gov (United States)

Helmick, Daniel; Okon, Avi; DiCicco, Matt

2006-01-01

Five techniques for sensing forces with a manipulator are compared analytically and experimentally. The techniques compared are: a six-axis wrist force/torque sensor, joint torque sensors, link strain gauges, motor current sensors, and flexibility modeling. The accuracy and repeatability fo each technique is quantified and compared.

Application of a rat hindlimb model: a prediction of force spaces reachable through stimulation of nerve fascicles.

Science.gov (United States)

Johnson, Will L; Jindrich, Devin L; Zhong, Hui; Roy, Roland R; Edgerton, V Reggie

2011-12-01

A device to generate standing or locomotion through chronically placed electrodes has not been fully developed due in part to limitations of clinical experimentation and the high number of muscle activation inputs of the leg. We investigated the feasibility of functional electrical stimulation paradigms that minimize the input dimensions for controlling the limbs by stimulating at nerve fascicles, utilizing a model of the rat hindlimb, which combined previously collected morphological data with muscle physiological parameters presented herein. As validation of the model, we investigated the suitability of a lumped-parameter model for the prediction of muscle activation during dynamic tasks. Using the validated model, we found that the space of forces producible through activation of muscle groups sharing common nerve fascicles was nonlinearly dependent on the number of discrete muscle groups that could be individually activated (equivalently, the neuroanatomical level of activation). Seven commonly innervated muscle groups were sufficient to produce 78% of the force space producible through individual activation of the 42 modeled hindlimb muscles. This novel, neuroanatomically derived reduction in input dimension emphasizes the potential to simplify controllers for functional electrical stimulation to improve functional recovery after a neuromuscular injury.

The effects of repeated Ozurdex injections on ocular hypertension.

Science.gov (United States)

Bahadorani, Sepehr; Krambeer, Chelsey; Wannamaker, Kendall; Tie, Wayne; Jansen, Michael; Espitia, Jason; Sohn, Jeong-Hyeon; Singer, Michael A

2018-01-01

The purpose of this study was to correlate the degree of ocular hypertension with the number of Ozurdex injections. Intraocular pressure (IOP) fluctuations for a total of 183 injections were studied over a period of at least 12 months. The main indications for treatment were uveitis, diabetic macular edema, and retinal vein occlusion. Results of the study demonstrate that repeated Ozurdex injections do not increase the frequency of IOP spikes beyond 30 mmHg. For lower IOPs, however, a positive correlation exists. Furthermore, patients with primary open angle glaucoma and uveitis had the highest IOP response to repeated injections. On average, patients with an IOP of ≥28.6 mmHg received pressure lowering medications, after which their IOP reached a stable level (16.7 mmHg) without the need for additional interventions. The data support the conclusion that multiple Ozurdex injections does not increase the frequency of IOP spikes beyond 30 mmHg, but patients still must be closely monitored if they have a history of primary open angle glaucoma.

Using OpenTarget to Generate Potential Countermeasures for Long-Term Space Exposure from Data Available on GeneLab

Science.gov (United States)

Beheshti, Afshin

2018-01-01

GeneLab as a general tool for the scientific community; Utilizing GeneLab datasets to generate hypothesis and determining potential biological targets against health risks due to long-term space missions; How can OpenTarget be used to discover novel drugs to test as countermeasures that can be utilized by astronauts.

Finite element analysis of the effect of force directions on tooth movement in extraction space closure with miniscrew sliding mechanics.

Science.gov (United States)

Kojima, Yukio; Kawamura, Jun; Fukui, Hisao

2012-10-01

Miniscrews placed in bone have been used as orthodontic anchorage in extraction space closure with sliding mechanics. The movement patterns of the teeth depend on the force directions. To move the teeth in a desired pattern, the appropriate direction of force must be selected. The purpose of this article is to clarify the relationship between force directions and movement patterns. By using the finite element method, orthodontic movements were simulated based on the remodeling law of the alveolar bone. The power arm length and the miniscrew position were varied to change the force directions. When the power arm was lengthened, rotation of the entire maxillary dentition decreased. The posterior teeth were effective for preventing rotation of the anterior teeth through an archwire. In cases of a high position of a miniscrew, bodily tooth movement was almost achieved. The vertical component of the force produced intrusion or extrusion of the entire dentition. Within the limits of the method, the mechanical simulations demonstrated the effect of force direction on movement patterns. Copyright © 2012 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

Hydrostatic force sensor

International Nuclear Information System (INIS)

Evans, M.S.; Stoughton, R.S.; Kazerooni, H.

1994-08-01

This paper presents a theoretical and experimental investigation of a new kind of force sensor which detects forces by measuring an induced pressure change in a material of large Poisson's ratio. In this investigation we develop mathematical expressions for the sensor's sensitivity and bandwidth, and show that its sensitivity can be much larger and its bandwidth is usually smaller than those of existing strain-gage-type sensors. This force sensor is well-suited for measuring large but slowly varying forces. It can be installed in a space smaller than that required by existing sensors

Thermal Comfort Assessment in The Open Space in Bandung Case Study Dago Street and Riau Street

Science.gov (United States)

Sugangga, M.; Janesonia, K. I.; Illiyin, D. F.; Donny Koerniawan, M.

2018-05-01

Bandung’s temperature has been higher since last years. This phenomenon affects the level of thermal comfort in open space. One indicator that determines the thermal comfort level is the type of activity performed by the open space user. Riau Street and Dago Street are corridors that are often used by the people for strolling, jogging, shopping. Dago Street has special event every Sunday namely car free day. Both corridors have different orientation; Dago Street is North to South corridor while Riau Street’s is West to East. The goal of the study is to compare people’s perception of thermal comfort in both corridors. This research uses two methods, namely qualitative method and quantitative method. Based on the results of qualitative analysis found that the thermal conditions in Dago Street more comfortable than the Riau Street. The result of quantitative analysis found that the average PET (thermal comfort indices) value of Dago Street was at 27.5 °C PET and Riau Street 28.6 °C PET. Dago Street is considered more convenient because it has a lower PET value than Riau Street. The people perception of thermal comfort is very important to start the steps for designing the orientation of street in urban design.

Dispersive force between dissimilar materials: Geometrical effects

International Nuclear Information System (INIS)

Noguez, Cecilia; Roman-Velazquez, C.E.

2004-01-01

We calculate the Casimir force or dispersive van der Waals force between a spherical nanoparticle and a planar substrate, both with arbitrary dielectric properties. We show that the force between the sphere and half-space can be calculated through the interacting surface plasmons of the bodies. Using a Spectral Representation formalism, we show that the force of a sphere made of a material A and a half-space made of a material B differs from the case when the sphere is made of B, and the half-space is made of A. We find that the difference depends on the plasma frequency of the materials, the geometry, and the distance of separation between the sphere and half-space. The differences show the importance of the geometry, and make evident the necessity of realistic descriptions of the system beyond the Derjaguin Approximation or Proximity Theorem Approximation

Security Force Assistance: Building Foreign Security Forces and Joint Doctrine for the Future of U.S. Regional Security

National Research Council Canada - National Science Library

Sullivan, Michael D

2008-01-01

.... From training the Nicaraguan National Guard to the most recent efforts in Iraq, the U.S. Military has repeatedly shown a need for a coherent and comprehensive plan to develop foreign security forces. U.S...

Finding industrial space

DEFF Research Database (Denmark)

Riesto, Svava

2011-01-01

Spaces marked by industrial rationalities are easily overseen or rejected without further consideration during urban redevelopment processes. This is striking in an era where urban space is often seen as a cornerstone for the future city. This article investigates different concepts of open space...... that have been operative in the redevelopment of the so-called Carlsberg Square in Copenhagen between 2006-2009. It concludes with general remarcs on dealing with the complex matter open space in the practices of design and heritage management in urban redevelopment processes....

Governing conditions of repeatable Barkhausen noise response

International Nuclear Information System (INIS)

Stupakov, O.; Pal'a, J.; Takagi, T.; Uchimoto, T.

2009-01-01

The paper is devoted to the establishment of experimental conditions, which ensure the repeatability of magnetic Barkhausen noise testing in practice. For this task, the measurements were performed on open flat samples using different experimental configurations, including: different magnetization frequencies, sampling rates, and filter cut-off frequencies; using a sample-wrapped coil and using attached pick-up coils of various dimensions, with different lift-offs of a single yoke magnet and of the attached coil. The sample magnetization was controlled by a vertical array of three Hall sensors; their readings were extrapolated to the sample surface to precisely define its field. After analysis of the results, a scheme for an optimized sensor with a controlled field waveform was suggested to improve the measurement repeatability. The important issues of signal processing and parameter applicability were also discussed in detail.

Tactile feedback is an effective instrument for the training of grasping with a prosthesis at low- and medium-force levels.

Science.gov (United States)

De Nunzio, Alessandro Marco; Dosen, Strahinja; Lemling, Sabrina; Markovic, Marko; Schweisfurth, Meike Annika; Ge, Nan; Graimann, Bernhard; Falla, Deborah; Farina, Dario

2017-08-01

Grasping is a complex task routinely performed in an anticipatory (feedforward) manner, where sensory feedback is responsible for learning and updating the internal model of grasp dynamics. This study aims at evaluating whether providing a proportional tactile force feedback during the myoelectric control of a prosthesis facilitates learning a stable internal model of the prosthesis force control. Ten able-bodied subjects controlled a sensorized myoelectric prosthesis performing four blocks of consecutive grasps at three levels of target force (30, 50, and 70%), repeatedly closing the fully opened hand. In the first and third block, the subjects received tactile and visual feedback, respectively, while during the second and fourth block, the feedback was removed. The subjects also performed an additional block with no feedback 1 day after the training (Retest). The median and interquartile range of the generated forces was computed to assess the accuracy and precision of force control. The results demonstrated that the feedback was indeed an effective instrument for the training of prosthesis control. After the training, the subjects were still able to accurately generate the desired force for the low and medium target (30 and 50% of maximum force available in a prosthesis), despite the feedback being removed within the session and during the retest (low target force). However, the training was substantially less successful for high forces (70% of prosthesis maximum force), where subjects exhibited a substantial loss of accuracy as soon as the feedback was removed. The precision of control decreased with higher forces and it was consistent across conditions, determined by an intrinsic variability of repeated myoelectric grasping. This study demonstrated that the subject could rely on the tactile feedback to adjust the motor command to the prosthesis across trials. The subjects adjusted the mean level of muscle activation (accuracy), whereas the precision could not

Space Weather Influence on Relative Motion Control using the Touchless Electrostatic Tractor

Science.gov (United States)

Hogan, Erik A.; Schaub, Hanspeter

2016-09-01

With recent interest in the use of electrostatic forces for contactless tugging and attitude control of noncooperative objects for orbital servicing and active debris mitigation, the need for a method of remote charge control arises. In this paper, the use of a directed electron beam for remote charge control is considered in conjunction with the relative motion control. A tug vehicle emits an electron beam onto a deputy object, charging it negatively. At the same time, the tug is charged positively due to beam emission, resulting in an attractive electrostatic force. The relative position feedback control between the tug and the passive debris object is studied subject to the charging being created through an electron beam. Employing the nominal variations of the GEO space weather conditions across longitude slots, two electrostatic tugging strategies are considered. First, the electron beam current is adjusted throughout the orbit in order to maximize this resulting electrostatic force. This open-loop control strategy compensates for changes in the nominally expected local space weather environment in the GEO region to adjust for fluctuations in the local plasma return currents. Second, the performance impact of using a fixed electron beam current on the electrostatic tractor is studied if the same natural space weather variations are assumed. The fixed electron beam current shows a minor performance penalty (<5 %) while providing a much simpler implementation that does not require any knowledge of local space weather conditions.

A reliable unipedal stance test for the assessment of balance using a force platform.

Science.gov (United States)

Ponce-González, J G; Sanchis-Moysi, J; González-Henriquez, J J; Arteaga-Ortiz, R; Calbet, J A L; Dorado, C

2014-02-01

The aim was to develop a unipedal stance test for the assessment of balance using a force platform. A single-leg balance test was conducted in 23 students (mean ± SD) age: 23 ± 3 years) in a standard position limiting the movement of the arms and non-supporting leg. Six attempts, with both the jumping (JL) and the contralateral leg (CL), were performed under 3 conditions: 1) eyes opened; 2) eyes closed; 3) eyes opened and executing a precision task. The same protocol was repeated two-week apart. The mean and the best result of the six attempts performed each day were taken as representative of balance. The speed of the centre of pressure (CP-Speed) showed excellent reliability for the "best result" analysis in all tests (ICCs 0.87-0.97), except in the test with the eyes closed performed on the CL (ICCtest. The single-leg stance balance test proposed is a reliable method to assess balance, especially when performed in a static position, with the eyes opened and using the best result of six attempts as reference, independently of the stance leg.

Repeated oral administration of capsaicin increases anxiety-like ...

Indian Academy of Sciences (India)

2013-07-22

Jul 22, 2013 ... open arms was reduced in capsaicin-treated rats compared with control rats. In forced ... TRPV1 receptors was also observed in the prefrontal cortex, nucleus ... its implication in the control of psycho-motor activities. Indeed ...

A Network-Based Algorithm for Clustering Multivariate Repeated Measures Data

Science.gov (United States)

Koslovsky, Matthew; Arellano, John; Schaefer, Caroline; Feiveson, Alan; Young, Millennia; Lee, Stuart

2017-01-01

The National Aeronautics and Space Administration (NASA) Astronaut Corps is a unique occupational cohort for which vast amounts of measures data have been collected repeatedly in research or operational studies pre-, in-, and post-flight, as well as during multiple clinical care visits. In exploratory analyses aimed at generating hypotheses regarding physiological changes associated with spaceflight exposure, such as impaired vision, it is of interest to identify anomalies and trends across these expansive datasets. Multivariate clustering algorithms for repeated measures data may help parse the data to identify homogeneous groups of astronauts that have higher risks for a particular physiological change. However, available clustering methods may not be able to accommodate the complex data structures found in NASA data, since the methods often rely on strict model assumptions, require equally-spaced and balanced assessment times, cannot accommodate missing data or differing time scales across variables, and cannot process continuous and discrete data simultaneously. To fill this gap, we propose a network-based, multivariate clustering algorithm for repeated measures data that can be tailored to fit various research settings. Using simulated data, we demonstrate how our method can be used to identify patterns in complex data structures found in practice.

The effect of repeated testing vs repeated practice on skills learning in undergraduate dental education.

Science.gov (United States)

Sennhenn-Kirchner, S; Goerlich, Y; Kirchner, B; Notbohm, M; Schiekirka, S; Simmenroth, A; Raupach, T

2018-02-01

Recent studies in undergraduate medical education have demonstrated the advantage of repeated testing over repeated practice with regard to knowledge and skills retention. The aim of this study was to investigate whether this "testing effect" also applies to skills retention in undergraduate dental education. In this prospective, randomised controlled trial, fourth-year dental students at Göttingen University Medical Centre participated in a training session on surgical suturing in winter term 2014/2015. Following this, they were either assigned to two sessions of additional skills training (group A) or two sessions of skills assessment with feedback (group B). These sessions were spaced over a period of 4 weeks. Skills retention was assessed in a summative objective structured clinical examination (OSCE) at the end of term, that is 6 months after the initial teaching session. A total of 32 students completed the study. With regard to suturing, OSCE performance was significantly better in group B than group A (81.9±13.1% vs 63.0±15.4%; P=0.001; Cohen's d=1.33). There was no significant OSCE performance difference in the two groups with regard to other learning objectives that were addressed in the end-of-term examination. Thus, the group difference was specific to suturing skills. This is the first study to demonstrate that in dental education, repeated testing produces more favourable skills retention than repeated practice. Test-enhanced learning might be a viable concept for skills retention in undergraduate dentistry education. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Effects of experimental muscle pain on force variability during task-related and three directional isometric force task

DEFF Research Database (Denmark)

Mista, Christian Ariel; Graven-Nielsen, Thomas

2013-01-01

was measured using sample entropy (SEn). Three-way repeated measures ANOVA with factors level of contraction, pain/control, and time were performed for the CV, the CoP, and the SEn of each component of the force. In the tangential forces, no significant effects were found for the 3D matching tasks. The ANOVA.......05). In the task-related force, no significant effects were found for the CV during the three-dimensional task or for the task-related task. Finally, the ANOVA analysis of sample entropy showed a significant interaction between pain/control and time (P

Topology of actions and homogeneous spaces

International Nuclear Information System (INIS)

Kozlov, Konstantin L

2013-01-01

Topologization of a group of homeomorphisms and its action provide additional possibilities for studying the topological space, the group of homeomorphisms, and their interconnections. The subject of the paper is the use of the property of d-openness of an action (introduced by Ancel under the name of weak micro-transitivity) in the study of spaces with various forms of homogeneity. It is proved that a d-open action of a Čech-complete group is open. A characterization of Polish SLH spaces using d-openness is given, and it is established that any separable metrizable SLH space has an SLH completion that is a Polish space. Furthermore, the completion is realized in coordination with the completion of the acting group with respect to the two-sided uniformity. A sufficient condition is given for extension of a d-open action to the completion of the space with respect to the maximal equiuniformity with preservation of d-openness. A result of van Mill is generalized, namely, it is proved that any homogeneous CDH metrizable compactum is the only G-compactification of the space of rational numbers for the action of some Polish group. Bibliography: 39 titles.

Models of anxiety: responses of mice to novelty and open spaces in a 3D maze.

Science.gov (United States)

Ennaceur, A; Michalikova, S; van Rensburg, R; Chazot, P L

2006-11-01

The present report describes the emotional responses of different strains of mice to exposure to a novel open space model of anxiety using a 3D spatial navigation task. The 3D maze is modification of the radial maze with flexible arms that can be raised above or lowered below the horizontal level of a central platform. To access the arms animals need to cross a bridge linking the arms to the central platform. In this model, mice are exposed to novelty in an unfamiliar open space setting with no safe alternative. Fear from novelty is compounded with the need to explore. The drive to escape and the drive to approach are intermingled making this open space model radically different from the current models of anxiety which provide animals with the choice between safe and anxiogenic spaces. In a series of experiments, we examined the behaviour of different groups of mice from C57, C3H, CD1 and Balb/c strains. In the first experiment, different groups of C57 mice were tested in one of the three arms configurations. In the second experiment, C57 mice were compared to C3H mice. In the third experiment, C57 mice were compared to CD1 and Balb/c mice in the raised arm configuration over three successive sessions. In the fourth experiment, we examined the behaviour of C57 mice in the lowered arm configuration with an open and an enclosed central. In the final experiment, we examined the difference between C57 and C3H mice of both genders. Using several spatio-temporal parameters of the transition responses between central platform, bridges and arms, we have been able to show consistent results demonstrating significant differences between C57 and C3H mice, and between Balb/c and both C57 and CD1 mice. C3H appear more anxious than C57 mice, and Balb/c mice seem more anxious than C57 and CD1 mice. We also observed significant differences between sexes in C3H mice but not in C57 mice. C3H male mice appear more anxious than C3H female mice and than both C57 male and female mice

14 CFR 23.155 - Elevator control force in maneuvers.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Elevator control force in maneuvers. 23.155 Section 23.155 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Controllability and Maneuverability § 23.155 Elevator control force in maneuvers. (a) The elevator control force...

Enhanced precision of ankle torque measure with an open-unit dynamometer mounted with a 3D force-torque sensor.

Science.gov (United States)

Toumi, A; Leteneur, S; Gillet, C; Debril, J-F; Decoufour, N; Barbier, F; Jakobi, J M; Simoneau-Buessinger, Emilie

2015-11-01

Many studies have focused on maximum torque exerted by ankle joint muscles during plantar flexion. While strength parameters are typically measured with isokinetic or isolated ankle dynamometers, these devices often present substantial limitations for the measurement of torque because they account for force in only 1 dimension (1D), and the device often constrains the body in a position that augments torque through counter movements. The purposes of this study were to determine the contribution of body position to ankle plantar-flexion torque and to assess the use of 1D and 3D torque sensors. A custom designed 'Booted, Open-Unit, Three dimension, Transportable, Ergometer' (B.O.T.T.E.) was used to quantify plantar flexion in two conditions: (1) when the participant was restrained within the unit (locked-unit) and (2) when the participant's position was independent of the ankle dynamometer (open-unit). Ten young males performed maximal voluntary isometric plantar-flexion contractions using the B.O.T.T.E. in open and locked-unit mechanical configurations. The B.O.T.T.E. was reliable with ICC higher than 0.90, and CV lower than 7 %. The plantar-flexion maximal resultant torque was significantly higher in the locked-unit compared with open-unit configuration (P torque sensor significantly underestimated the proper capacity of plantar-flexion torque production (P torque should be performed with an open-unit dynamometer mounted with a 3D sensor that is exclusive of accessory muscles but inclusive of all ankle joint movements.

Actuator forces in CFD: RANS and LES modeling in OpenFOAM

International Nuclear Information System (INIS)

Schito, P; Zasso, A

2014-01-01

Wind turbine wakes are a very challenging topic for scientific computations, but modern CFD frameworks and latest HPC centers allow setting up numerical computations on the wake induced by the wind turbine. The main issues is that the correct modeling of the wake is related to the correct modeling of the interaction between the blade and the incoming flow. The aim of the proposed work is to estimate the aerodynamic forces acting on the blades in order to correctly generate the rotor wake applying equivalent aerodynamic force source on the flow. The definition of a blade forces is done developing a model able to correctly estimate this aerodynamic forces as a function of the local flow seen by the blade during its revolution

Compound list: 1% cholesterol + 0.25% sodium cholate [Open TG-GATEs

Lifescience Database Archive (English)

Full Text Available 1% cholesterol + 0.25% sodium cholate CH+DS-Na 00161 ftp://ftp.biosciencedbc.jp/arc...hive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/1%25_cholesterol_%2B_0.25%25_sodium_cholate.Rat.in_vivo.Liver.Repeat.zip ...

Quantitative assessment of force fields on both low-energy conformational basins and transition-state regions of the (phi-psi) space

NARCIS (Netherlands)

Liu, Z.; Ensing, B.; Moore, P.B.

2011-01-01

The free energy surfaces (FESs) of alanine dipeptide are studied to illustrate a new strategy to assess the performance of classical molecular mechanics force field on the full range of the (phi-psi) conformational space. The FES is obtained from metadynamics simulations with five commonly used

ÁREAS VERDES URBANAS, ESPAÇOS LIVRES PARA O LAZER / Urban green areas, open spaces for leisure

Directory of Open Access Journals (Sweden)

Kátia MAZZEI Mazzei

2007-06-01

Full Text Available The creation and the management of Conservation Units in urban areas, as in the category ofintegral protection as of sustainable use, aims to improve the quality of life of the urban citizenat the same time that it promotes an improvement in the urban environment quality, endowingthe urban space with vegetal covering and fundamental green areas to the reproduction of thenatural cycle and maintenance of the dynamic balance. In the urban environment, the differentcategories of open spaces and the indexes of green area per inhabitant intend to offer optionsto the leisure and recreation activities, besides of characterizing as strategic instruments forthe municipal planning, integrating the characteristics and the limits of the environment to theurban expansion.

Task-space sensory feedback control of robot manipulators

CERN Document Server

Cheah, Chien Chern

2015-01-01

This book presents recent advances in robot control theory on task space sensory feedback control of robot manipulators. By using sensory feedback information, the robot control systems are robust to various uncertainties in modelling and calibration errors of the sensors. Several sensory task space control methods that do not require exact knowledge of either kinematics or dynamics of robots, are presented. Some useful methods such as approximate Jacobian control, adaptive Jacobian control, region control and multiple task space regional feedback are included. These formulations and methods give robots a high degree of flexibility in dealing with unforeseen changes and uncertainties in its kinematics and dynamics, which is similar to human reaching movements and tool manipulation. It also leads to the solution of several long-standing problems and open issues in robot control, such as force control with constraint uncertainty, control of multi-fingered robot hand with uncertain contact points, singularity i...

Space charge effects: tune shifts and resonances

International Nuclear Information System (INIS)

Weng, W.T.

1986-08-01

The effects of space charge and beam-beam interactions on single particle motion in the transverse degree of freedom are considered. The space charge force and the resulting incoherent tune shift are described, and examples are given from the AGS and CERN's PSB. Equations of motion are given for resonances in the presence of the space charge force, and particle behavior is examined under resonance and space charge conditions. Resonance phase space structure is described with and without space charge. Uniform and bunched beams are compared. Beam-beam forces and resonances and beam-beam detuning are described. 18 refs., 15 figs

Space Charge Effects

CERN Document Server

Ferrario, M.; Palumbo, L.

2014-12-19

The space charge forces are those generated directly by the charge distribution, with the inclusion of the image charges and currents due to the interaction of the beam with a perfectly conducting smooth pipe. Space charge forces are responsible for several unwanted phenomena related to beam dynamics, such as energy loss, shift of the synchronous phase and frequency , shift of the betatron frequencies, and instabilities. We will discuss in this lecture the main feature of space charge effects in high-energy storage rings as well as in low-energy linacs and transport lines.

Force and power characteristics of a resistive exercise device for use in space

Science.gov (United States)

Berg, Hans E.; Tesch, Per A.

We have developed a non-gravity dependent mechanical device, which provides resistance during coupled concentric and eccentric muscle actions, through the inertia of a spinning fly-wheel (Fly-Wheel Ergometry; FWE). Our research shows that lower-limb FWE exercise can produce forces and thus muscular stress comparable to what is typical of advanced resistance training using free weights. FWE also offers greater training stimuli during eccentric relative to concentric muscle actions, as evidenced by force and electromyographic (EMG) measurements. Muscle use of specific muscle groups, as assessed by the exercise-induced contrast shift of magnetic resonance images, is similar during lower-limb FWE and the barbell squat. Unlike free-weight exercise, FWE allows for maximal voluntary effort in each repetition of an exercise bout. Likewise, FWE exercise, not unassisted free-weight exercise, produces eccentric "overload". Collectively, the inherent features of this resistive exercise device and the results of the physiological evaluations we have performed, suggest that resistance exercise using FWE could be used as an effective exercise counter-measure in space. The flywheel principle can be employed to any exercise configuration and designed into a compact device allowing for exercises stressing those muscles and bone structures, which are thought to be most affected by long-duration spaceflight.

Cervical spine mobilisation forces applied by physiotherapy students.

Science.gov (United States)

Snodgrass, Suzanne J; Rivett, Darren A; Robertson, Val J; Stojanovski, Elizabeth

2010-06-01

Postero-anterior (PA) mobilisation is commonly used in cervical spine treatment and included in physiotherapy curricula. The manual forces that students apply while learning cervical mobilisation are not known. Quantifying these forces informs the development of strategies for learning to apply cervical mobilisation effectively and safely. This study describes the mechanical properties of cervical PA mobilisation techniques applied by students, and investigates factors associated with force application. Physiotherapy students (n=120) mobilised one of 32 asymptomatic subjects. Students applied Grades I to IV central and unilateral PA mobilisation to C2 and C7 of one asymptomatic subject. Manual forces were measured in three directions using an instrumented treatment table. Spinal stiffness of mobilised subjects was measured at C2 and C7 using a device that applied a standard oscillating force while measuring this force and its concurrent displacement. Analysis of variance was used to determine differences between techniques and grades, intraclass correlation coefficients (ICC) were used to calculate the inter- and intrastudent repeatability of forces, and linear regression was used to determine the associations between applied forces and characteristics of students and mobilised subjects. Mobilisation forces increased from Grades I to IV (highest mean peak force, Grade IV C7 central PA technique: 63.7N). Interstudent reliability was poor [ICC(2,1)=0.23, 95% confidence interval (CI) 0.14 to 0.43], but intrastudent repeatability of forces was somewhat better (0.83, 95% CI 0.81 to 0.86). Higher applied force was associated with greater C7 stiffness, increased frequency of thumb pain, male gender of the student or mobilised subject, and a student being earlier in their learning process. Lower forces were associated with greater C2 stiffness. This study describes the cervical mobilisation forces applied by students, and the characteristics of the student and mobilised

Comment on 'Relation between space charge limited current and power loss in open drift tubes' [Phys. Plasmas 13, 073101 (2006)

International Nuclear Information System (INIS)

Swanekamp, S. B.; Schumer, J. W.

2007-01-01

In Phys Plasmas 13, 073101 (2006), the drop in the space-charge-limited (SCL) current for a beam injected into a space with an open boundary is analyzed with an electromagnetic particle-in-cell code. The authors explained the power loss observed at the open boundary as the loss of electromagnetic radiation created from the deceleration of electrons in the gap, and they developed an effective voltage theory to predict the drop in the SCL current observed in the simulations. In this Comment, we show that, provided the current remains below the SCL value, the electric and magnetic fields are constant in time so that power loss from the open boundary is a dc phenomenon with no rf power leaving through the boundary. We show that the electric and magnetic fields are static in time and static fields DO NOT RADIATE. Instead, the electron beam charges the collector plate, which causes a real electrostatic electric field to develop. The electron energy loss is not due to radiation but rather to the work done by this electrostatic field on the electrons as they move across the gap. This is precisely the energy dissipated in the matched resistance across the open boundary, which is a consequence of the boundary condition. Furthermore, since a real electrostatic potential develops, the voltage drop is real and there is no need to call the voltage drop an effective voltage

Cooking and palatability traits of beef longissimus steaks cooked with a belt grill or an open hearth electric broiler.

Science.gov (United States)

Wheeler, T L; Shackelford, S D; Koohmaraie, M

1998-11-01

The objective of this experiment was to compare the effects of belt grill and Open Hearth electric broiler cookery on palatability and cooking traits of longissimus steaks. The longissimus thoracis from carcasses of grain-fed steers or heifers was used. Duplicate measurements were made for Warner-Bratzler shear force at 3 and at 14 d after slaughter (n = 180) and trained sensory evaluation at 14 d after slaughter (n = 91) using both cooking methods. Belt grill-cooked samples had lower (P<.01) percentage of cooking losses (21.5 vs 25.8%) and higher (P<.01) shear force values (4.6 vs 4.3 kg) than electric broiler-cooked samples. Repeatability of duplicate measurements was higher for cooking losses (.58 vs .23) and shear force values (.85 vs .64) for belt grill than for electric broiler cooked samples. Belt grilled steaks had lower (P<.01) cooking losses (20.2 vs 29.8%); higher (P<.01) tenderness (7.0 vs 6.7) and juiciness (6.0 vs 5.1); and lower (P<.02) connective tissue amount (7.7 vs 7.8), beef flavor intensity (5.0 vs 5.1), and off-flavor (3.2 vs 3.3) ratings than steaks cooked with the electric broiler. Belt grill cooking increased the repeatability of duplicate sensory measurements for tenderness (.87 vs .71), connective tissue amount (.66 vs .30), and juiciness (.51 vs .08) ratings, and cooking losses (.63 vs .18) compared with cooking with the electric broiler. Belt grill cooking increased the precision for measurements of cooking, Warner-Bratzler shear force, and palatability traits of beef longissimus thoracis.

Space Sustainment: A New Approach for America in Space

Science.gov (United States)

2014-12-01

international community toward promoting market incentives in international space law. This would open up the competitive space for new entrants ...announces- new -space-situational-awareness-satellite-program.aspx. 29. Gruss, “U.S. Space Assets Face Growing Threat .” 30. McDougall, Heavens and the...November–December 2014 Air & Space Power Journal | 117 SCHRIEVER ESSAY WINNER SECOND PLACE Space Sustainment A New Approach for America in Space Lt

A discrete-space urban model with environmental amenities

Science.gov (United States)

Liaila Tajibaeva; Robert G. Haight; Stephen Polasky

2008-01-01

This paper analyzes the effects of providing environmental amenities associated with open space in a discrete-space urban model and characterizes optimal provision of open space across a metropolitan area. The discrete-space model assumes distinct neighborhoods in which developable land is homogeneous within a neighborhood but heterogeneous across neighborhoods. Open...

Effect of contact stiffness on wedge calibration of lateral force in atomic force microscopy

International Nuclear Information System (INIS)

Wang Fei; Zhao Xuezeng

2007-01-01

Quantitative friction measurement of nanomaterials in atomic force microscope requires accurate calibration method for lateral force. The effect of contact stiffness on lateral force calibration of atomic force microscope is discussed in detail and an improved calibration method is presented. The calibration factor derived from the original method increased with the applied normal load, which indicates that separate calibration should be required for every given applied normal load to keep the accuracy of friction measurement. We improve the original method by introducing the contact factor, which is derived from the contact stiffness between the tip and the sample, to the calculation of calibration factors. The improved method makes the calculation of calibration factors under different applied normal loads possible without repeating the calibration procedure. Comparative experiments on a silicon wafer have been done by both the two methods to validate the method in this article

Space Radiation Induced Cytogenetic Damage in the Blood Lymphocytes of Astronauts: Persistence of Damage After Flight and the Effects of Repeat Long Duration Missions

Science.gov (United States)

George, Kerry; Rhone, Jordan; Chappell, L. J.; Cucinotta, F. A.

2010-01-01

Cytogenetic damage was assessed in blood lymphocytes from astronauts before and after they participated in long-duration space missions of three months or more. The frequency of chromosome damage was measured by fluorescence in situ hybridization (FISH) chromosome painting before flight and at various intervals from a few days to many months after return from the mission. For all individuals, the frequency of chromosome exchanges measured within a month of return from space was higher than their prefight yield. However, some individuals showed a temporal decline in chromosome damage with time after flight. Statistical analysis using combined data for all astronauts indicated a significant overall decreasing trend in total chromosome exchanges with time after flight, although this trend was not seen for all astronauts and the yield of chromosome damage in some individuals actually increased with time after flight. The decreasing trend in total exchanges was slightly more significant when statistical analysis was restricted to data collected more than 220 days after return from flight. In addition, limited data on multiple flights show a lack of correlation between time in space and translocation yields. Data from three crewmembers who has participated in two separate long-duration space missions provide limited information on the effect of repeat flights and show a possible adaptive response to space radiation exposure.

Modelling window opening behaviour in Danish dwellings

DEFF Research Database (Denmark)

Andersen, Rune Vinther; Olesen, Bjarne W.; Toftum, Jørn

2011-01-01

In this paper we present and analyse data from two studies of window opening behaviour in residential buildings in Denmark. Based on measurements of indoor environment, weather and window opening behaviour in 15 dwellings, we propose a model that will predict window opening behaviour. The data...... showed that other factors than thermal effects impact the behaviour of the occupants. Some of these factors were included in the model. We present data from repeated questionnaire surveys that show that occupants tend to adjust heating setpoints, adjust clothing and operate windows when feeling thermally...

Consumer acceptance of salt-reduced 'soy sauce' foods over rapidly repeated exposure

NARCIS (Netherlands)

Kremer, S.; Shimojo, R.; Holthuysen, N.T.E.; Köster, E.P.; Mojet, J.

2013-01-01

The stability of the liking for salt reduced products was tested in a rapidly repeated exposure study using soup and bread (with ham). Salt was partially replaced by naturally brewed soy sauce. First, 44 consumers performed 5 two-alternative forced choice tests to establish the exchange rate (ER) at

The Second Space Race

Science.gov (United States)

Fawkes, S.

This paper compares and contrasts the characteristics of the first space race, which ran from the late 1950s to the late 1990s, and the second space race that began with the successful space flight of SpaceShipOne in 2004. The first space race was between superpowers seeking to establish geo-political dominance in the Cold War. The second space race will be between competing companies seeking to establish low cost access to space for ordinary people. The first space race achieved its geo- political objectives but did not open up low cost access to space but rather restricted access to a select few, highly trained astronauts and cosmonauts. The second space race, driven by the size and growth of the travel and tourism industry, promises to open up access to space to millions of space tourists.

Space and Air Force: Rhetoric or Reality

National Research Council Canada - National Science Library

Cashin, James

1999-01-01

... to meet requirements set forth in the National Security Strategy (NSS). Joint Vision 2010, the Air Force's Global Engagement, and several long-range plans all establish requirements that can only be fulfilled through the application of spacepower...

Safety after extended repeated use of ulipristal acetate for uterine fibroids

DEFF Research Database (Denmark)

Fauser, Bart C J M; Donnez, Jacques; Bouchard, Philippe

2017-01-01

OBJECTIVE: To assess long term safety of extended repeated 3-month courses of ulipristal acetate (UPA) 10 mg/day, for up to 8 courses, with focus on endometrial and laboratory safety parameters. METHODS: This long-term, multi-center, open-label cohort, follow up study consisted of up to 8 consecu...

Analysis of flame acceleration in open or vented obstructed pipes

Science.gov (United States)

Bychkov, Vitaly; Sadek, Jad; Akkerman, V'yacheslav

2017-01-01

While flame propagation through obstacles is often associated with turbulence and/or shocks, Bychkov et al. [V. Bychkov et al., Phys. Rev. Lett. 101, 164501 (2008), 10.1103/PhysRevLett.101.164501] have revealed a shockless, conceptually laminar mechanism of extremely fast flame acceleration in semiopen obstructed pipes (one end of a pipe is closed; a flame is ignited at the closed end and propagates towards the open one). The acceleration is devoted to a powerful jet flow produced by delayed combustion in the spaces between the obstacles, with turbulence playing only a supplementary role in this process. In the present work, this formulation is extended to pipes with both ends open in order to describe the recent experiments and modeling by Yanez et al. [J. Yanez et al., arXiv:1208.6453] as well as the simulations by Middha and Hansen [P. Middha and O. R. Hansen, Process Safety Prog. 27, 192 (2008) 10.1002/prs.10242]. It is demonstrated that flames accelerate strongly in open or vented obstructed pipes and the acceleration mechanism is similar to that in semiopen ones (shockless and laminar), although acceleration is weaker in open pipes. Starting with an inviscid approximation, we subsequently incorporate hydraulic resistance (viscous forces) into the analysis for the sake of comparing its role to that of a jet flow driving acceleration. It is shown that hydraulic resistance is actually not required to drive flame acceleration. In contrast, this is a supplementary effect, which moderates acceleration. On the other hand, viscous forces are nevertheless an important effect because they are responsible for the initial delay occurring before the flame acceleration onset, which is observed in the experiments and simulations. Accounting for this effect provides good agreement between the experiments, modeling, and the present theory.

SpacePy - a Python-based library of tools for the space sciences

International Nuclear Information System (INIS)

Morley, Steven K.; Welling, Daniel T.; Koller, Josef; Larsen, Brian A.; Henderson, Michael G.

2010-01-01

Space science deals with the bodies within the solar system and the interplanetary medium; the primary focus is on atmospheres and above - at Earth the short timescale variation in the the geomagnetic field, the Van Allen radiation belts and the deposition of energy into the upper atmosphere are key areas of investigation. SpacePy is a package for Python, targeted at the space sciences, that aims to make basic data analysis, modeling and visualization easier. It builds on the capabilities of the well-known NumPy and MatPlotLib packages. Publication quality output direct from analyses is emphasized. The SpacePy project seeks to promote accurate and open research standards by providing an open environment for code development. In the space physics community there has long been a significant reliance on proprietary languages that restrict free transfer of data and reproducibility of results. By providing a comprehensive, open-source library of widely used analysis and visualization tools in a free, modern and intuitive language, we hope that this reliance will be diminished. SpacePy includes implementations of widely used empirical models, statistical techniques used frequently in space science (e.g. superposed epoch analysis), and interfaces to advanced tools such as electron drift shell calculations for radiation belt studies. SpacePy also provides analysis and visualization tools for components of the Space Weather Modeling Framework - currently this only includes the BATS-R-US 3-D magnetohydrodynamic model and the RAM ring current model - including streamline tracing in vector fields. Further development is currently underway. External libraries, which include well-known magnetic field models, high-precision time conversions and coordinate transformations are wrapped for access from Python using SWIG and f2py. The rest of the tools have been implemented directly in Python. The provision of open-source tools to perform common tasks will provide openness in the

Improving the contact resistance at low force using gold coated carbon nanotube surfaces

Science.gov (United States)

McBride, J. W.; Yunus, E. M.; Spearing, S. M.

2010-04-01

Investigations to determine the electrical contact performance under repeated cycles at low force conditions for carbon-nanotube (CNT) coated surfaces were performed. The surfaces under investigation consisted of multi-walled CNT synthesized on a silicon substrate and coated with a gold film. These planar surfaces were mounted on the tip of a PZT actuator and contacted with a plated Au hemispherical probe. The dynamic applied force used was 1 mN. The contact resistance (Rc) of these surfaces was investigated with the applied force and with repeated loading cycles performed for stability testing. The surfaces were compared with a reference Au-Au contact under the same experimental conditions. This initial study shows the potential for the application of gold coated CNT surfaces as an interface in low force electrical contact applications.

The Quantum Space Phase Transitions for Particles and Force Fields