Space plasma observations - observations of solar-terrestrial environment. Space Weather Forecast

International Nuclear Information System (INIS)

Sagawa, Eiichi; Akioka, Maki

1996-01-01

The space environment becomes more important than ever before because of the expansion in the utilization of near-earth space and the increase in the vulnerability of large scale systems on the ground such as electrical power grids. The concept of the Space Weather Forecast program emerged from the accumulation of understanding on basic physical processes and from our activities as one of the regional warning centers of the international network of space environment services. (author)

Conformally compactified homogeneous spaces (Possible Observable Consequences)

International Nuclear Information System (INIS)

Budinich, P.

1995-01-01

Some arguments based on the possible spontaneous violation of the Cosmological Principles (represented by the observed large-scale structures of galaxies), the Cartan-geometry of simple spinors and on the Fock-formulation of hydrogen-atom wave-equation in momentum-space, are presented in favour of the hypothesis that space-time and momentum-space should be both conformally compactified and represented by the two four-dimensional homogeneous spaces of the conformal group, both isomorphic to (S 3 X S 1 )/Z 2 and correlated by conformal inversion. Within this framework, the possible common origin for the S0(4) symmetry underlying the geometrical structure of the Universe, of Kepler orbits and of the H-atom is discussed. On of the consequences of the proposed hypothesis could be that any quantum field theory should be naturally free from both infrared and ultraviolet divergences. But then physical spaces defined as those where physical phenomena may be best described, could be different from those homogeneous spaces. A simple, exactly soluble, toy model, valid for a two-dimensional space-time is presented where the conjecture conformally compactified space-time and momentum-space are both isomorphic to (S 1 X S 1 )/Z 2 , while the physical spaces are two finite lattice which are dual since Fourier transforms, represented by finite, discrete, sums may be well defined on them. Furthermore, a q-deformed SU q (1,1) may be represented on them if q is a root of unity. (author). 22 refs, 3 figs

Impact of number of repeated scans on model observer performance for a low-contrast detection task in computed tomography.

Science.gov (United States)

Ma, Chi; Yu, Lifeng; Chen, Baiyu; Favazza, Christopher; Leng, Shuai; McCollough, Cynthia

2016-04-01

Channelized Hotelling observer (CHO) models have been shown to correlate well with human observers for several phantom-based detection/classification tasks in clinical computed tomography (CT). A large number of repeated scans were used to achieve an accurate estimate of the model's template. The purpose of this study is to investigate how the experimental and CHO model parameters affect the minimum required number of repeated scans. A phantom containing 21 low-contrast objects was scanned on a 128-slice CT scanner at three dose levels. Each scan was repeated 100 times. For each experimental configuration, the low-contrast detectability, quantified as the area under receiver operating characteristic curve, [Formula: see text], was calculated using a previously validated CHO with randomly selected subsets of scans, ranging from 10 to 100. Using [Formula: see text] from the 100 scans as the reference, the accuracy from a smaller number of scans was determined. Our results demonstrated that the minimum number of repeated scans increased when the radiation dose level decreased, object size and contrast level decreased, and the number of channels increased. As a general trend, it increased as the low-contrast detectability decreased. This study provides a basis for the experimental design of task-based image quality assessment in clinical CT using CHO.

Confined space ventilation by shipyard welders: observed use and effectiveness.

Science.gov (United States)

Pouzou, Jane G; Warner, Chris; Neitzel, Richard L; Croteau, Gerry A; Yost, Michael G; Seixas, Noah S

2015-01-01

Shipbuilding involves intensive welding activities within enclosed and confined spaces, and although ventilation is commonly used in the industry, its use and effectiveness has not been adequately documented. Workers engaged in welding in enclosed or confined spaces in two shipyards were observed for their use of ventilation and monitored for their exposure to particulate matter. The type of ventilation in use, its placement and face velocity, the movement of air within the space, and other ventilation-related parameters were recorded, along with task characteristics such as the type of welding, the welder's position, and the configuration of the space. Mechanical ventilation was present in about two-thirds of the 65 welding scenarios observed, with exhaust ventilation used predominantly in one shipyard and supply blowers predominantly in the other. Welders were observed working in apparent dead-spaces within the room in 53% of the cases, even where ventilation was in use. Respiratory protection was common in the two shipyards, observed in use in 77 and 100% of the cases. Welding method, the proximity of the welder's head to the fume, and air mixing were found to be significantly associated with the welder's exposure, while other characteristics of dilution ventilation did not produce appreciable differences in exposure level. These parameters associated with exposure reduction can be assessed subjectively and are thus good candidates for training on effective ventilation use during hot work in confined spaces. Ventilation used in confined space welding is often inadequate for controlling exposure to welding fume. © The Author 2014. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.

Fifty Years of Lightning Observations from Space

Science.gov (United States)

Christian, H. J., Jr.

2017-12-01

Some of the earliest satellites, starting with OSO (1965), ARIEL (1967), and RAE (1968), detected lightning using either optical and RF sensors, although that was not their intent. One of the earliest instruments designed to detect lightning was the PBE (1977). The use of space to study lightning activity has exploded since these early days. The advent of focal-plane imaging arrays made it possible to develop high performance optical lightning sensors. Prior to the use of charged-coupled devices (CCD), most space-based lightning sensors used only a few photo-diodes, which limited the location accuracy and detection efficiency (DE) of the instruments. With CCDs, one can limit the field of view of each detector (pixel), and thus improve the signal to noise ratio over single-detectors that summed the light reflected from many clouds with the lightning produced by a single cloud. This pixelization enabled daytime DE to increase from a few percent to close to 90%. The OTD (1995), and the LIS (1997), were the first lightning sensors to utilize focal-plane arrays. Together they detected global lightning activity for more than twenty years, providing the first detailed information on the distribution of global lightning and its variability. The FORTE satellite was launched shortly after LIS, and became the first dedicated satellite to simultaneously measure RF and optical lightning emissions. It too used a CCD focal plane to detect and locate lightning. In November 2016, the GLM became the first lightning instrument in geostationary orbit. Shortly thereafter, China placed its GLI in orbit. Lightning sensors in geostationary orbit significantly increase the value of space-based observations. For the first time, lightning activity can be monitored continuously, over large areas of the Earth with high, uniform DE and location accuracy. In addition to observing standard lightning, a number of sensors have been placed in orbit to detect transient luminous events and

Optimal observables and phase-space ambiguities

International Nuclear Information System (INIS)

Nachtmann, O.; Nagel, F.

2005-01-01

Optimal observables are known to lead to minimal statistical errors on parameters for a given normalised event distribution of a physics reaction. Thereby all statistical correlations are taken into account. Therefore, on the one hand they are a useful tool to extract values on a set of parameters from measured data. On the other hand one can calculate the minimal constraints on these parameters achievable by any data-analysis method for the specific reaction. In case the final states can be reconstructed without ambiguities optimal observables have a particularly simple form. We give explicit formulae for the optimal observables for generic reactions in case of ambiguities in the reconstruction of the final state and for general parameterisation of the final-state phase space. (orig.)

Space Debris and Observational Astronomy

Science.gov (United States)

Seitzer, Patrick

2018-01-01

Since the launch of Sputnik 1 in 1957, astronomers have faced an increasing number of artificial objects contaminating their images of the night sky. Currently almost 17000 objects larger than 10 cm are tracked and have current orbits in the public catalog. Active missions are only a small fraction of these objects. Most are inactive satellites, rocket bodies, and fragments of larger objects: all space debris. Several mega-constellations are planned which will increase this number by 20% or more in low Earth orbit (LEO). In terms of observational astronomy, this population of Earth orbiting objects has three implications: 1) the number of streaks and glints from spacecraft will only increase. There are some practical steps that can be taken to minimize the number of such streaks and glints in astronomical imaging data. 2) The risk to damage to orbiting astronomical telescopes will only increase, particularly those in LEO. 3) If you are working on a plan for an orbiting telescope project, then there are specific steps that must be taken to minimize space debris generation during the mission lifetime, and actions to safely dispose of the spacecraft at end of mission to prevent it from becoming space debris and a risk to other missions. These steps may involve sacrifices to mission performance and lifetime, but are essential in today's orbital environment.

Observer-dependent quantum vacua in curved space. II

International Nuclear Information System (INIS)

Castagnino, M.A.; Sztrajman, J.B.

1989-01-01

An observer-dependent Hamiltonian is introduced in order to describe massless spin-1 particles in curved space-times. The vacuum state is defined by means of Hamiltonian diagonalization and minimization, which turns out to be equivalent criteria. This method works in an arbitrary geometry, although a condition on the fluid of observers is required. Computations give the vacua commonly accepted in the literature

Observations from Space and the Future of Meteorology

Science.gov (United States)

Tepper, Morris

1974-01-01

Describes space-based observations and other aspects of meterology that will enable weather forecasters to lengthen the scale of predictability from the current day-to-day basis to one week or longer. (Author/GS)

An observational study of defensible space in the neighbourhood park

Science.gov (United States)

Marzukhi, M. A.; Afiq, M. A.; Zaki, S. Ahmad; Ling, O. H. L.

2018-02-01

The planning of neighborhood park is important to provide space for interaction, leisure, and recreation among residents in any neighbourhood area. However, on an almost daily basis, newspapers report inappropriate incidents such as snatch theft, robbery and street attack that occurred in the neighborhood park. These cases reflect the significance of physical planning and design of neighborhood park that directly affect the safety and comfort of the users. Thus, this study attempts to engage with the defensible space concept in ensuring the security elements be applied in the planning of the recreational area. This study adopts a qualitative method form of research that is retrofitted to an observational study. The observational study is significant for revealing the condition of a neighbourhood park in the ‘real-world,’ in which direct observation is conducted on Taman Tasik Puchong Perdana. The observer focused on four elements or variables of defensible space concept including the provision of facilities in the neighborhood park, territoriality, surveillance, image and milieu. The findings revealed that the planning of Taman Tasik Puchong Perdana does not deliberate the defensible space elements, which may contribute to the crime activities in the park. In these circumstances, the planning of neighbourhood park needs to include proposals for the implementation of defensible space in response to the challenges underpinned by crime problems. Besides, the awareness among the residents needs to be emphasized with the support from local authorities and other organizations to manage and sustain the safety environment in the neighborhood park.

Space observations for global and regional studies of the biosphere

Science.gov (United States)

Cihlar, J.; Li, Z.; Chen, J.; Sellers, P.; Hall, F.

1994-01-01

The capability to make space-based measurements of Earth at high spatial and temporal resolutions, which would not otherwise be economically or practically feasible, became available just in time to contribute to scientific understanding of the interactive processes governing the total Earth system. Such understanding has now become essential in order to take practical steps which would counteract or mitigate the pervasive impact of the growing human population on the future habitability of the Earth. The paper reviews the rationale for using space observations for studies of climate and terrestrial ecosystems at global and regional scales, as well as the requirements for such observations for studies of climate and ecosystem dynamics. The present status of these developments is reported along with initiatives under way to advance the use of satellite observations for Earth system studies. The most important contribution of space observations is the provision of physical or biophysical parameters for models representing various components of the Earth system. Examples of such parameters are given for climatic and ecosystem studies.

Repeated sharp flux dropouts observed at 6.6 R/subE/ during a geomagnetic storm

International Nuclear Information System (INIS)

Su, S.; Fritz, T.A.; Konradi, A.

1976-01-01

A number of repeated rapid flux dropouts have been observed at 6.6 R/subE/ by the NOAA low-energy proton detectors on board the ATS 6 satellite during the July 4--6, 1974, geomagnetic storm period. These rapid flux changes are caused by the fact that the outer boundary of the trapped radiation region moves back and forth past the satellite. Although a tilting field line configuration can cause the boundary to pass the satellite, as has frequently been reported in the literature, the boundary is shown to be distorted by a large surface wave traveling eastward around the earth. The maximum velocity of the wave was observed to be approx. =40 km/s

Earth observations from space: the first 50 years of scientific achievements

National Research Council Canada - National Science Library

Committee on Scientific Accomplishments of Earth Observations from Space, National Research Council

.... At the request of the National Aeronautics and Space Administration, the National Research Council convened a committee to examine the scientific accomplishments that have resulted from space-based observations...

Methane hydrate distribution from prolonged and repeated formation in natural and compacted sand samples: X-ray CT observations

Energy Technology Data Exchange (ETDEWEB)

Rees, E.V.L.; Kneafsey, T.J.; Seol, Y.

2010-07-01

To study physical properties of methane gas hydrate-bearing sediments, it is necessary to synthesize laboratory samples due to the limited availability of cores from natural deposits. X-ray computed tomography (CT) and other observations have shown gas hydrate to occur in a number of morphologies over a variety of sediment types. To aid in understanding formation and growth patterns of hydrate in sediments, methane hydrate was repeatedly formed in laboratory-packed sand samples and in a natural sediment core from the Mount Elbert Stratigraphic Test Well. CT scanning was performed during hydrate formation and decomposition steps, and periodically while the hydrate samples remained under stable conditions for up to 60 days. The investigation revealed the impact of water saturation on location and morphology of hydrate in both laboratory and natural sediments during repeated hydrate formations. Significant redistribution of hydrate and water in the samples was observed over both the short and long term.

Short-term Changes of Apparent Optical Properties in a Shallow Water Environment: Observations from Repeated Airborne Hyperspectral Measurements

Science.gov (United States)

Zhang, M.; English, D. C.; Hu, C.; Carlson, P. R., Jr.; Muller-Karger, F. E.; Toro-Farmer, G.; Herwitz, S. R.

2016-02-01

An atmospheric correction algorithm has been developed for AISA imagery over optically shallow waters in Sugarloaf Key of the Florida Keys. The AISA data were collected repeatedly during several days in May 2012, October 2012, and May 2013. A non-zero near-infrared (NIR) remote sensing reflectance (Rrs) was accounted for through iterations, based on the relationship of field-measured Rrs between the NIR and red wavelengths. Validation showed mean ratios of 0.94 to 1.002 between AISA-derived and field-measured Rrs in the blue to red wavelengths, with uncertainties generally turbidity (light attenuation) and bottom contributions. Some of these changes are larger than two times of the Rrs uncertainties from the AISA retrievals, therefore representing statistically significant changes that can be well observed from airborne measurements. The case study suggests that repeated airborne measurements may be used to study short-term changes in shallow water environments, and such a capacity may be enhanced with future geostationary satellite missions specifically designed to observe coastal ecosystems.

International Space Station Earth Observations Working Group

Science.gov (United States)

Stefanov, William L.; Oikawa, Koki

2015-01-01

The multilateral Earth Observations Working Group (EOWG) was chartered in May 2012 in order to improve coordination and collaboration of Earth observing payloads, research, and applications on the International Space Station (ISS). The EOWG derives its authority from the ISS Program Science Forum, and a NASA representative serves as a permanent co-chair. A rotating co-chair position can be occupied by any of the international partners, following concurrence by the other partners; a JAXA representative is the current co-chair. Primary functions of the EOWG include, 1) the exchange of information on plans for payloads, from science and application objectives to instrument development, data collection, distribution and research; 2) recognition and facilitation of opportunities for international collaboration in order to optimize benefits from different instruments; and 3) provide a formal ISS Program interface for collection and application of remotely sensed data collected in response to natural disasters through the International Charter, Space and Major Disasters. Recent examples of EOWG activities include coordination of bilateral data sharing protocols between NASA and TsNIIMash for use of crew time and instruments in support of ATV5 reentry imaging activities; discussion of continued use and support of the Nightpod camera mount system by NASA and ESA; and review and revision of international partner contributions on Earth observations to the ISS Program Benefits to Humanity publication.

Optical observations on critical ionization velocity experiments in space

International Nuclear Information System (INIS)

Stenbaek-Nielsen, H.C.

1993-01-01

A number of Critical Ionization Velocity (CIV) experiments have been performed in space. CIV has been observed in laboratory experiments, but experiments in space have been inconclusive. Most space experiments have used barium which ionizes easily, and with emission lines from both neutrals and ions in the visible optical observations can be made from the ground. Also other elements, such as xenon, strontium and calcium, have been used. High initial ionization in some barium release experiments has been claimed due to CIV. However, a number of reactions between barium and the ambient plasma have been suggested as more likely processes. Currently the most popular process in this debate is charge exchange with O + . This process has a large cross section, but is it large enough? The cross section for charge exchange with calcium should be even larger, but in a double release of barium and calcium (part of the NASA CRRES release experiments) most ionization was observed from the barium release. Moreover, if charge exchange is the dominant process, the amount of ionization should relate to the oxygen ion density, and that does not appear to be the case. Other processes, such as associative ionization, have also been proposed, but yields are uncertain because the reaction rates are very poorly known

Space Observations for Global Change

Science.gov (United States)

Rasool, S. I.

1991-01-01

There is now compelling evidence that man's activities are changing both the composition of the atmospheric and the global landscape quite drastically. The consequences of these changes on the global climate of the 21st century is currently a hotly debated subject. Global models of a coupled Earth-ocean-atmosphere system are still very primitive and progress in this area appears largely data limited, specially over the global biosphere. A concerted effort on monitoring biospheric functions on scales from pixels to global and days to decades needs to be coordinated on an international scale in order to address the questions related to global change. An international program of space observations and ground research was described.

Repeating and non-repeating fast radio bursts from binary neutron star mergers

Science.gov (United States)

Yamasaki, Shotaro; Totani, Tomonori; Kiuchi, Kenta

2018-04-01

Most fast radio bursts (FRB) do not show evidence of repetition, and such non-repeating FRBs may be produced at the time of a merger of binary neutron stars (BNS), provided that the BNS merger rate is close to the high end of the currently possible range. However, the merger environment is polluted by dynamical ejecta, which may prohibit the radio signal from propagating. We examine this by using a general-relativistic simulation of a BNS merger, and show that the ejecta appears about 1 ms after the rotation speed of the merged star becomes the maximum. Therefore there is a time window in which an FRB signal can reach outside, and the short duration of non-repeating FRBs can be explained by screening after ejecta formation. A fraction of BNS mergers may leave a rapidly rotating and stable neutron star, and such objects may be the origin of repeating FRBs like FRB 121102. We show that a merger remnant would appear as a repeating FRB on a time scale of ˜1-10 yr, and expected properties are consistent with the observations of FRB 121102. We construct an FRB rate evolution model that includes these two populations of repeating and non-repeating FRBs from BNS mergers, and show that the detection rate of repeating FRBs relative to non-repeating ones rapidly increases with improving search sensitivity. This may explain why only the repeating FRB 121102 was discovered by the most sensitive FRB search with Arecibo. Several predictions are made, including the appearance of a repeating FRB 1-10 yr after a BNS merger that is localized by gravitational waves and subsequent electromagnetic radiation.

Humanly space objects-Perception and connection with the observer

Science.gov (United States)

Balint, Tibor S.; Hall, Ashley

2015-05-01

Expanding humanity into space is an inevitable step in our quest to explore our world. Yet space exploration is costly, and the awaiting environment challenges us with extreme cold, heat, vacuum and radiation, unlike anything encountered on Earth. Thus, the few pioneers who experience it needed to be well protected throughout their spaceflight. The resulting isolation heightens the senses and increases the desire to make humanly connections with any other perceived manifestation of life. Such connections may occur via sensory inputs, namely vision, touch, sound, smell, and taste. This then follows the process of sensing, interpreting, and recognizing familiar patterns, or learning from new experiences. The desire to connect could even transfer to observed objects, if their movements and characteristics trigger the appropriate desires from the observer. When ordered in a familiar way, for example visual stimuli from lights and movements of an object, it may create a perceived real bond with an observer, and evoke the feeling of surprise when the expected behavior changes to something no longer predictable or recognizable. These behavior patterns can be designed into an object and performed autonomously in front of an observer, in our case an astronaut. The experience may introduce multiple responses, including communication, connection, empathy, order, and disorder. While emotions are clearly evoked in the observer and may seem one sided, in effect the object itself provides a decoupled bond, connectivity and communication between the observer and the artist-designer of the object. In this paper we will discuss examples from the field of arts and other domains, including robotics, where human perception through object interaction was explored, and investigate the starting point for new innovative design concepts and future prototype designs, that extend these experiences beyond the boundaries of Earth, while taking advantage of remoteness and the zero gravity

Using the SPICE system to help plan and interpret space science observations

Science.gov (United States)

Acton, Charles H., Jr.

1993-01-01

A portable multimission information system named SPICE is used to assemble, archive, and provide easy user access to viewing geometry and other ancillary information needed by space scientists to interpret observations of bodies within our solar system. The modular nature of this system lends it to use in planning such observations as well. With a successful proof of concept on Voyager, the SPICE system has been adapted to the Magellan, Galileo and Mars Observer missions, and to a variety of ground based operations. Adaptation of SPICE for Cassini and the Russian Mars 94/96 projects is underway, and work on Cassini will follow, SPICE has been used to support observation planning for moving targets on the Hubble Space Telescope Project. Applications for SPICE on earth science, space physics and other astrophysics missions are under consideration.

Earth Observation from Space - The Issue of Environmental Sustainability

Science.gov (United States)

Durrieu, Sylvie; Nelson, Ross F.

2013-01-01

Remote sensing scientists work under assumptions that should not be taken for granted and should, therefore, be challenged. These assumptions include the following: 1. Space, especially Low Earth Orbit (LEO), will always be available to governmental and commercial space entities that launch Earth remote sensing missions. 2. Space launches are benign with respect to environmental impacts. 3. Minimization of Type 1 error, which provides increased confidence in the experimental outcome, is the best way to assess the significance of environmental change. 4. Large-area remote sensing investigations, i.e. national, continental, global studies, are best done from space. 5. National space missions should trump international, cooperative space missions to ensure national control and distribution of the data products. At best, all of these points are arguable, and in some cases, they're wrong. Development of observational space systems that are compatible with sustainability principles should be a primary concern when Earth remote sensing space systems are envisioned, designed, and launched. The discussion is based on the hypothesis that reducing the environmental impacts of thedata acquisition step,which is at the very beginning of the information streamleading to decision and action, will enhance coherence in the information streamand strengthen the capacity of measurement processes to meet their stated functional goal, i.e. sustainable management of Earth resources. We suggest that unconventional points of view should be adopted and when appropriate, remedial measures considered that could help to reduce the environmental footprint of space remote sensing and of Earth observation and monitoring systems in general. This article discusses these five assumptions inthe contextof sustainablemanagementof Earth's resources. Takingeachassumptioninturn,we find the following: (1) Space debris may limit access to Low Earth Orbit over the next decades. (2) Relatively speaking, given

Quantum tomography, phase-space observables and generalized Markov kernels

International Nuclear Information System (INIS)

Pellonpaeae, Juha-Pekka

2009-01-01

We construct a generalized Markov kernel which transforms the observable associated with the homodyne tomography into a covariant phase-space observable with a regular kernel state. Illustrative examples are given in the cases of a 'Schroedinger cat' kernel state and the Cahill-Glauber s-parametrized distributions. Also we consider an example of a kernel state when the generalized Markov kernel cannot be constructed.

Inter- and intra-operator reliability and repeatability of shear wave elastography in the liver: a study in healthy volunteers.

Science.gov (United States)

Hudson, John M; Milot, Laurent; Parry, Craig; Williams, Ross; Burns, Peter N

2013-06-01

This study assessed the reproducibility of shear wave elastography (SWE) in the liver of healthy volunteers. Intra- and inter-operator reliability and repeatability were quantified in three different liver segments in a sample of 15 subjects, scanned during four independent sessions (two scans on day 1, two scans 1 wk later) by two operators. A total of 1440 measurements were made. Reproducibility was assessed using the intra-class correlation coefficient (ICC) and a repeated measures analysis of variance. The shear wave speed was measured and used to estimate Young's modulus using the Supersonics Imagine Aixplorer. The median Young's modulus measured through the inter-costal space was 5.55 ± 0.74 kPa. The intra-operator reliability was better for same-day evaluations (ICC = 0.91) than the inter-operator reliability (ICC = 0.78). Intra-observer agreement decreased when scans were repeated on a different day. Inter-session repeatability was between 3.3% and 9.9% for intra-day repeated scans, compared with to 6.5%-12% for inter-day repeated scans. No significant difference was observed in subjects with a body mass index greater or less than 25 kg/m(2). Copyright © 2013 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

Multi-satellite observations of magnetic fields in space plasmas

International Nuclear Information System (INIS)

Potemra, T.A.; Zanetti, L.J.; Bythrow, P.F.; Erlandson, R.E.

1987-01-01

The most common method of detecting electric currents in space has been by virtue of the magnetic perturbations they produce. A satellite can pass through a field-aligned ''Birkeland'' current and measure the in-situ magnetic perturbations. Satellite-borne magnetic field experiments may also be used to observe characteristics of resonant oscillations of the Earth's magnetic field at ULF frequencies. Examples of such measurements with magnetic field experiments on the Viking, AMPTE/CCE, and DMSP-F7 satellites will be presented. The Viking satellite, launched in February, 1986, is Sweden's first satellite and is in a polar orbit with 3.1 R/sub e/ apogee. AMPTE/CCE was launched in August, 1984, with satellites from West Germany and the United Kingdom, for the purpose of creating artificial comets in space. It is in an equatorial orbit with a 8.8 R/sub e/ apogee. The Defense Meteorological Satellite Program (DMSP)-F7 satellite was launched in October, 1983 into an 800 km circular sun-synchronous orbit in the 0830-2030 magnetic local time plane. Viking and AMPTE/CCE observed harmonic ULF pulsations when they were near the same flux tube, but separated by about 10 R/sub e/. These unique observations are used to investigate the characteristics and sources of multiple field line resonances of Alfven waves. On another occasion, Viking and DMSP-F7 observed similar magnetic perturbations at widely separated locations. The authors interpret these perturbations as due to a complicated system of large-scale stable Birkeland currents in the morning sector. This multi-satellite data set is in the early stages of exploration, but already confirms the usefulness of coordinated multi-position observations of magnetic fields in space

Aerosol and cloud observations from the Lidar In-space Technology Experiment

Science.gov (United States)

Winker, D. M.

1995-01-01

The Lidar In-Space Technology Experiment (LITE) is a backscatter lidar built by NASA Langley Research Center to fly on the Space Shuttle. The purpose of the program was to develop the engineering processes required for space lidar and to demonstrate applications of space lidar to remote sensing of the atmosphere. The instrument was flown on Discovery in September 1994. Global observations of clouds and aerosols were made between the latitudes of 57 deg N and 57 deg S during 10 days of the mission.

The international earth observing system: a cultural debate about earth sciences from space

NARCIS (Netherlands)

Menenti, M.

1996-01-01

This paper gives an overview of the International Earth Observing System, i.e. the combined earth observation programmes of space agencies worldwide and of the relevance of advanced space-borne sensor systems to the study and understanding of interactions between land surface and atmosphere. The

Assimilating irregularly spaced sparsely observed turbulent signals with hierarchical Bayesian reduced stochastic filters

International Nuclear Information System (INIS)

Brown, Kristen A.; Harlim, John

2013-01-01

In this paper, we consider a practical filtering approach for assimilating irregularly spaced, sparsely observed turbulent signals through a hierarchical Bayesian reduced stochastic filtering framework. The proposed hierarchical Bayesian approach consists of two steps, blending a data-driven interpolation scheme and the Mean Stochastic Model (MSM) filter. We examine the potential of using the deterministic piecewise linear interpolation scheme and the ordinary kriging scheme in interpolating irregularly spaced raw data to regularly spaced processed data and the importance of dynamical constraint (through MSM) in filtering the processed data on a numerically stiff state estimation problem. In particular, we test this approach on a two-layer quasi-geostrophic model in a two-dimensional domain with a small radius of deformation to mimic ocean turbulence. Our numerical results suggest that the dynamical constraint becomes important when the observation noise variance is large. Second, we find that the filtered estimates with ordinary kriging are superior to those with linear interpolation when observation networks are not too sparse; such robust results are found from numerical simulations with many randomly simulated irregularly spaced observation networks, various observation time intervals, and observation error variances. Third, when the observation network is very sparse, we find that both the kriging and linear interpolations are comparable

Solar System Observations with the James Webb Space Telescope

OpenAIRE

Norwood, James; Hammel, Heidi; Milam, Stefanie; Stansberry, John; Lunine, Jonathan; Chanover, Nancy; Hines, Dean; Sonneborn, George; Tiscareno, Matthew; Brown, Michael; Ferruit, Pierre

2014-01-01

The James Webb Space Telescope will enable a wealth of new scientific investigations in the near- and mid-infrared, with sensitivity and spatial/spectral resolution greatly surpassing its predecessors. In this paper, we focus upon Solar System science facilitated by JWST, discussing the most current information available concerning JWST instrument properties and observing techniques relevant to planetary science. We also present numerous example observing scenarios for a wide variety of Solar...

REPEATABILITY OF THE FRENCH HIGHER VEGETATION TYPES ACCORDING

Directory of Open Access Journals (Sweden)

H. BRISSE

1998-04-01

Full Text Available Higher vegetation types are generally determined by successive approximations and defined by a common consent. Instead, they might be statistically determined and repeated, according to a numerical method called ‘socio-ecology’. This method deals only with floristical data, but gives them an ecological meaning by a previous calibration of the relations between plants, computed as ecological indices. It is applied to a pair of two homologous samples, each having 2.000 relevés and coming from the 60.000 relevés stored in the French data bank ‘Sophy’. Each sample covers the main ecological gradients of the bank, it defines a hierarchy of vegetation types and it explains half the peculiarity of a type with only 10 to 30 discriminant plants, out of the 5.000 plants observed in the relevés. Results : 1 The discriminant plants may characterize the vegetation types, including the higher ones, in a coherent and readable form. 2 In the two independent classifications, having different structures, the same vegetation types are repeated. They are the reciprocal nearest types, in the socio-ecological space. Though the two classifications have no one relevé in common, the repeated types have nearly the same discriminant plants. 3 At the highest level, two clear-cut main types show the difference between light and shadow. The same herbaceous discriminant plants, for a type, and the ligneous or sciaphilous ones, for the other, have similar fidelities and constancies in the two classifications. 4 Such a numerical agreement, instead of common consent, appears again in the sub-types, which remind the classical ones, but which are repeatable.

Simultaneous radar and spaced receiver VHF scintillation observations of ESF irregularities

Directory of Open Access Journals (Sweden)

D. Tiwari

2006-07-01

Full Text Available Simultaneous observations of equatorial spread F (ESF irregularities made on 10 nights during March-April 1998 and 1999, using an 18-MHz radar at Trivandrum (77° E, 8.5° N, dip 0.5° N and two spaced receivers recording scintillations on a 251-MHz signal at Tirunelveli (77.8° E, 8.7° N, dip 0.4° N, have been used to study the evolution of Equatorial Spread F (ESF irregularities. Case studies have been carried out on the day-to-day variability in ESF structure and dynamics, as observed by 18-MHz radar, and with spaced receiver measurements of average zonal drift Vo of the 251-MHz radio wave diffraction pattern on the ground, random velocity Vc, which is a measure of random changes in the characteristics of scintillation-producing irregularities, and maximum cross-correlation CI of the spaced receivers signals. Results show that in the initial phase of plasma bubble development, the greater the maximum height of ESF irregularities responsible for the radar backscatter, the greater the decorrelation is of the spaced receiver scintillation signals, indicating greater turbulence. The relationship of the maximum spectral width derived from the radar observations and CI also supports this result.

Astronomical Observations Astronomy and the Study of Deep Space

CERN Document Server

2010-01-01

Our Search for knowledge about the universe has been remarkable, heartbreaking, fantastical, and inspiring, and this search is just beginning. Astronomical Observations is part of a 7 book series that takes readers through a virtual time warp of our discovery. From the nascent space programs of the 1960's to today's space tourism and the promise of distant planet colonization, readers will be transfixed. Throughout this journey of the mind, Earth-bound explorers gain keen insight into the celestial phenomena that have fascinated humans for centuries. Thrilling narratives about indefatigable sc

The CEOS Atmospheric Composition Constellation: Enhancing the Value of Space-Based Observations

Science.gov (United States)

Eckman, Richard; Zehner, Claus; Al-Saadi, Jay

2015-01-01

The Committee on Earth Observation Satellites (CEOS) coordinates civil space-borne observations of the Earth. Participating agencies strive to enhance international coordination and data exchange and to optimize societal benefit. In recent years, CEOS has collaborated closely with the Group on Earth Observations (GEO) in implementing the Global Earth Observing System of Systems (GEOSS) space-based objectives. The goal of the CEOS Atmospheric Composition Constellation (ACC) is to collect and deliver data to improve monitoring, assessment and predictive capabilities for changes in the ozone layer, air quality and climate forcing associated with changes in the environment through coordination of existing and future international space assets. A project to coordinate and enhance the science value of a future constellation of geostationary sensors measuring parameters relevant to air quality supports the forthcoming European Sentinel-4, Korean GEMS, and US TEMPO missions. Recommendations have been developed for harmonization to mutually improve data quality and facilitate widespread use of the data products.

Quantitative analysis and prediction of curvature in leucine-rich repeat proteins.

Science.gov (United States)

Hindle, K Lauren; Bella, Jordi; Lovell, Simon C

2009-11-01

Leucine-rich repeat (LRR) proteins form a large and diverse family. They have a wide range of functions most of which involve the formation of protein-protein interactions. All known LRR structures form curved solenoids, although there is large variation in their curvature. It is this curvature that determines the shape and dimensions of the inner space available for ligand binding. Unfortunately, large-scale parameters such as the overall curvature of a protein domain are extremely difficult to predict. Here, we present a quantitative analysis of determinants of curvature of this family. Individual repeats typically range in length between 20 and 30 residues and have a variety of secondary structures on their convex side. The observed curvature of the LRR domains correlates poorly with the lengths of their individual repeats. We have, therefore, developed a scoring function based on the secondary structure of the convex side of the protein that allows prediction of the overall curvature with a high degree of accuracy. We also demonstrate the effectiveness of this method in selecting a suitable template for comparative modeling. We have developed an automated, quantitative protocol that can be used to predict accurately the curvature of leucine-rich repeat proteins of unknown structure from sequence alone. This protocol is available as an online resource at http://www.bioinf.manchester.ac.uk/curlrr/.

Comparison of the light flash phenomena observed in space and in laboratory experiments

International Nuclear Information System (INIS)

McNulty, P.J.; Pease, V.P.; Bond, V.P.

1976-01-01

Astronauts on Apollo and Skylab missions have reported observing a variety of visual phenomena when their eyes were closed and adapted to darkness. These observations were studied under controlled conditions during a number of sessions on board Apollo and Skylab spacecraft and the data available to date on these so-called light flashes is in the form of descriptions of the phenomena and frequency of occurrence. Similar visual phenomena have been demonstrated in a number of laboratories by exposing the eyes of human subjects to beams of neutrons, alphas, pions, and protons. More than one physical mechanism is involved in the laboratory and space phenomena. No direct comparison of the laboratory and space observations has been made by observers who have experienced both. However, the range of visual phenomena observed in the laboratory is consistent with the Apollo and Skylab observations. Measured detection efficiencies can be used to estimate the frequencies with which various phenomena would be observed if the subject was exposed to cosmic rays in space

Exploiting Orbital Data and Observation Campaigns to Improve Space Debris Models

Science.gov (United States)

Braun, V.; Horstmann, A.; Reihs, B.; Lemmens, S.; Merz, K.; Krag, H.

The European Space Agency (ESA) has been developing the Meteoroid and Space Debris Terrestrial Environment Reference (MASTER) software as the European reference model for space debris for more than 25 years. It is an event-based simulation of all known individual debris-generating events since 1957, including breakups, solid rocket motor firings and nuclear reactor core ejections. In 2014, the upgraded Debris Risk Assessment and Mitigation Analysis (DRAMA) tool suite was released. In the same year an ESA instruction made the standard ISO 24113:2011 on space debris mitigation requirements, adopted via the European Cooperation for Space Standardization (ECSS), applicable to all ESA missions. In order to verify the compliance of a space mission with those requirements, the DRAMA software is used to assess collision avoidance statistics, estimate the remaining orbital lifetime and evaluate the on-ground risk for controlled and uncontrolled reentries. In this paper, the approach to validate the MASTER and DRAMA tools is outlined. For objects larger than 1 cm, thus potentially being observable from ground, the MASTER model has been validated through dedicated observation campaigns. Recent campaign results shall be discussed. Moreover, catalogue data from the Space Surveillance Network (SSN) has been used to correlate the larger objects. In DRAMA, the assessment of collision avoidance statistics is based on orbit uncertainty information derived from Conjunction Data Messages (CDM) provided by the Joint Space Operations Center (JSpOC). They were collected for more than 20 ESA spacecraft in the recent years. The way this information is going to be used in a future DRAMA version is outlined and the comparison of estimated manoeuvre rates with real manoeuvres from the operations of ESA spacecraft is shown.

Earth observations during Space Shuttle flight STS-41 - Discovery's mission to planet earth

Science.gov (United States)

Lulla, Kamlesh P.; Helfert, Michael R.; Amsbury, David L.; Whitehead, Victor S.; Richards, Richard N.; Cabana, Robert D.; Shepherd, William M.; Akers, Thomas D.; Melnick, Bruce E.

1991-01-01

An overview of space flight STS-41 is presented, including personal observations and comments by the mission astronauts. The crew deployed the Ulysses spacecraft to study the polar regions of the sun and the interplanetary space above the poles. Environmental observations, including those of Lake Turkana, Lake Chad, biomass burning in Madagascar and Argentina, and circular features in Yucatan are described. Observations that include landforms and geology, continental sedimentation, desert landscapes, and river morphology are discussed.

The First Simultaneous Microlensing Observations by Two Space telescopes

DEFF Research Database (Denmark)

Shvartzvald, Y.; Li, Z.; Udalski, A.

2016-01-01

study the region of microlensing parameter space to which Swift is sensitive, finding that though Swift could not measure the microlens parallax with respect to ground-based observations for this event, it can be important for other events. Specifically, it is important for detecting nearby brown dwarfs...

Observation and simulation of AGW in Space

Science.gov (United States)

Kunitsyn, Vyacheslav; Kholodov, Alexander; Andreeva, Elena; Nesterov, Ivan; Padokhin, Artem; Vorontsov, Artem

2014-05-01

Examples are presented of satellite observations and imaging of AGW and related phenomena in space travelling ionospheric disturbances (TID). The structure of AGW perturbations was reconstructed by satellite radio tomography (RT) based on the signals of Global Navigation Satellite Systems (GNSS). The experiments use different GNSS, both low-orbiting (Russian Tsikada and American Transit) and high-orbiting (GPS, GLONASS, Galileo, Beidou). The examples of RT imaging of TIDs and AGWs from anthropogenic sources such as ground explosions, rocket launching, heating the ionosphere by high-power radio waves are presented. In the latter case, the corresponding AGWs and TIDs were generated in response to the modulation in the power of the heating wave. The natural AGW-like wave disturbances are frequently observed in the atmosphere and ionosphere in the form of variations in density and electron concentration. These phenomena are caused by the influence of the near-space environment, atmosphere, and surface phenomena including long-period vibrations of the Earth's surface, earthquakes, explosions, temperature heating, seisches, tsunami waves, etc. Examples of experimental RT reconstructions of wave disturbances associated with the earthquakes and tsunami waves are presented, and RT images of TIDs caused by the variations in the corpuscular ionization are demonstrated. The results of numerical modeling of AGW generation by some surface and volume sources are discussed. The milli-Hertz AGWs generated by these sources induce perturbations with a typical scale of a few hundred of kilometers at the heights of the middle atmosphere and ionosphere. The numerical modeling is based on the solution of equations of geophysical hydrodynamics. The results of the numerical simulations agree with the observations. The authors acknowledge the support of the Russian Foundation for Basic Research (grants 14-05-00855 and 13-05-01122), grant of the President of Russian Federation MK-2670

Space-based pseudo-fixed latitude observation mode based on the characteristics of geosynchronous orbit belt

Science.gov (United States)

Hu, Yun-peng; Chen, Lei; Huang, Jian-yu

2017-08-01

The US Lincoln Laboratory proved that space-based visible (SBV) observation is efficient to observe space objects, especially Geosynchronous Orbit (GEO) objects. After that, SBV observation plays an important role in the space surveillance. In this paper, a novel space-based observation mode is designed to observe all the GEO objects in a relatively short time. A low earth orbit (LEO) satellite, especially a dawn-dusk sun-synchronous orbit satellite, is useful for space-based observation. Thus, the observation mode for GEO objects is based on a dawn-dusk sun-synchronous orbit satellite. It is found that the Pinch Point (PP) regions proposed by the US Lincoln Laboratory are spreading based on the analysis of the evolution principles of GEO objects. As the PP regions becoming more and more widely in the future, many strategies based on it may not be efficient any more. Hence, the key point of the space-based observation strategy design for GEO objects should be emphasized on the whole GEO belt as far as possible. The pseudo-fixed latitude observation mode is proposed in this paper based on the characteristics of GEO belt. Unlike classical space-based observation modes, pseudo-fixed latitude observation mode makes use of the one-dimensional attitude adjustment of the observation satellite. The pseudo-fixed latitude observation mode is more reliable and simple in engineering, compared with the gazing observation mode which needs to adjust the attitude from the two dimensions. It includes two types of attitude adjustment, i.e. daily and continuous attitude adjustment. Therefore, the pseudo-fixed latitude observation mode has two characteristics. In a day, the latitude of the observation region is fixed and the scanning region is about a rectangle, while the latitude of the observation region centre changes each day in a long term based on a daily strategy. The capabilities of a pseudo-fixed latitude observation instrument with a 98° dawn-dusk sun-synchronous orbit are

Automated Detection of Small Bodies by Space Based Observation

Science.gov (United States)

Bidstrup, P. R.; Grillmayer, G.; Andersen, A. C.; Haack, H.; Jorgensen, J. L.

The number of known comets and asteroids is increasing every year. Up till now this number is including approximately 250,000 of the largest minor planets, as they are usually referred. These discoveries are due to the Earth-based observation which has intensified over the previous decades. Additionally larger telescopes and arrays of telescopes are being used for exploring our Solar System. It is believed that all near- Earth and Main-Belt asteroids of diameters above 10 to 30 km have been discovered, leaving these groups of objects as observationally complete. However, the cataloguing of smaller bodies is incomplete as only a very small fraction of the expected number has been discovered. It is estimated that approximately 1010 main belt asteroids in the size range 1 m to 1 km are too faint to be observed using Earth-based telescopes. In order to observe these small bodies, space-based search must be initiated to remove atmospheric disturbances and to minimize the distance to the asteroids and thereby minimising the requirement for long camera integration times. A new method of space-based detection of moving non-stellar objects is currently being developed utilising the Advanced Stellar Compass (ASC) built for spacecraft attitude determination by Ørsted, Danish Technical University. The ASC serves as a backbone technology in the project as it is capable of fully automated distinction of known and unknown celestial objects. By only processing objects of particular interest, i.e. moving objects, it will be possible to discover small bodies with a minimum of ground control, with the ultimate ambition of a fully automated space search probe. Currently, the ASC is being mounted on the Flying Laptop satellite of the Institute of Space Systems, Universität Stuttgart. It will, after a launch into a low Earth polar orbit in 2008, test the detection method with the ASC equipment that already had significant in-flight experience. A future use of the ASC based automated

Simultaneous radar and spaced receiver VHF scintillation observations of ESF irregularities

Directory of Open Access Journals (Sweden)

D. Tiwari

2006-07-01

Full Text Available Simultaneous observations of equatorial spread F (ESF irregularities made on 10 nights during March-April 1998 and 1999, using an 18-MHz radar at Trivandrum (77° E, 8.5° N, dip 0.5° N and two spaced receivers recording scintillations on a 251-MHz signal at Tirunelveli (77.8° E, 8.7° N, dip 0.4° N, have been used to study the evolution of Equatorial Spread F (ESF irregularities. Case studies have been carried out on the day-to-day variability in ESF structure and dynamics, as observed by 18-MHz radar, and with spaced receiver measurements of average zonal drift V_o of the 251-MHz radio wave diffraction pattern on the ground, random velocity V_c, which is a measure of random changes in the characteristics of scintillation-producing irregularities, and maximum cross-correlation C_I of the spaced receivers signals. Results show that in the initial phase of plasma bubble development, the greater the maximum height of ESF irregularities responsible for the radar backscatter, the greater the decorrelation is of the spaced receiver scintillation signals, indicating greater turbulence. The relationship of the maximum spectral width derived from the radar observations and C_I also supports this result.

Analyzing the capability of a radio telescope in a bistatic space debris observation system

International Nuclear Information System (INIS)

Zhao Zhe; Zhao You; Gao Peng-Qi

2013-01-01

A bistatic space debris observation system using a radio telescope as the receiving part is introduced. The detection capability of the system at different working frequencies is analyzed based on real instruments. The detection range of targets with a fixed radar cross section and the detection ability of small space debris at a fixed range are discussed. The simulations of this particular observation system at different transmitting powers are also implemented and the detection capability is discussed. The simulated results approximately match the actual experiments. The analysis in this paper provides a theoretical basis for developing a space debris observation system that can be built in China

Observing Tropospheric Ozone From Space

Science.gov (United States)

Fishman, Jack

2000-01-01

The importance of tropospheric ozone embraces a spectrum of relevant scientific issues ranging from local environmental concerns, such as damage to the biosphere and human health, to those that impact global change questions, Such is climate warming. From an observational perspective, the challenge is to determine the tropospheric ozone global distribution. Because its lifetime is short compared with other important greenhouse gases that have been monitored over the past several decades, the distribution of tropospheric ozone cannot be inferred from a relatively small set of monitoring stations. Therefore, the best way to obtain a true global picture is from the use of space-based instrumentation where important spatial gradients over vast ocean expanses and other uninhabited areas can be properly characterized. In this paper, the development of the capability to measure tropospheric ozone from space over the past 15 years is summarized. Research in the late 1980s successfully led to the determination of the climatology of tropospheric ozone as a function of season; more recently, the methodology has improved to the extent where regional air pollution episodes can be characterized. The most recent modifications now provide quasi-global (50 N) to 50 S) maps on a daily basis. Such a data set would allow for the study of long-range (intercontinental) transport of air pollution and the quantification of how regional emissions feed into the global tropospheric ozone budget. Future measurement capabilities within this decade promise to offer the ability to provide Concurrent maps of the precursors to the in situ formation of tropospheric ozone from which the scientific community will gain unprecedented insight into the processes that control global tropospheric chemistry

Geomagnetic Observations for Main Field Studies

DEFF Research Database (Denmark)

Matzka, Jürgen; Chulliat, A.; Mandea, M.

2010-01-01

Direct measurements of the geomagnetic field have been made for more than 400 years, beginning with individual determinations of the angle between geographic and magnetic North. This was followed by the start of continuous time series of full vector measurements at geomagnetic observatories...... and the beginning of geomagnetic repeat stations surveys in the 19th century. In the second half of the 20th century, true global coverage with geomagnetic field measurements was accomplished by magnetometer payloads on low-Earth-orbiting satellites. This article describes the procedures and instruments...... for magnetic field measurements on ground and in space and covers geomagnetic observatories, repeat stations, automatic observatories, satellites and historic observations. Special emphasis is laid on the global network of geomagnetic observatories....

Phase space properties of charged fields in theories of local observables

International Nuclear Information System (INIS)

Buchholz, D.; D'Antoni, C.

1994-10-01

Within the setting of algebraic quantum field theory a relation between phase-space properties of observables and charged fields is established. These properties are expressed in terms of compactness and nuclarity conditions which are the basis for the characterization of theories with physically reasonable causal and thermal features. Relevant concepts and results of phase space analysis in algebraic qunatum field theory are reviewed and the underlying ideas are outlined. (orig.)

Using observational methods to evaluate public open spaces and physical activity in Brazil.

Science.gov (United States)

Hino A A, F; Reis, Rodrigo S; Ribeiro, Isabela C; Parra, Diana C; Brownson, Ross C; Fermino, Rogerio C

2010-07-01

Open public spaces have been identified as important facilities to promote physical activity (PA) at the community level. The main goals of this study are to describe open public spaces user's characteristics and to explore to what extent these characteristics are associated with PA behavior. A system of direct observation was used to evaluate the PA levels on parks and squares (smaller parks) and users's characteristics (gender and age). The 4 parks and 4 squares observed were selected from neighborhoods with different socioeconomic status and environmental characteristics. The settings were observed 3 times a day, 6 days per week, during 2 weeks. More men than women were observed in parks (63.1%) and squares (70.0%) as well as more adults and adolescents than older adults and children. Users were more physically active in parks (men = 34.1%, women = 36.1%) than in squares (men = 25.5%, women 22.8%). The characteristics of public open spaces may affect PA in the observed places. Initiatives to improve PA levels in community settings should consider users' characteristics and preferences to be more effective and reach a larger number of people.

Observing the Anthropocene from Space

Science.gov (United States)

Burrows, John

The industrial revolution, which began in the UK in the late 18th century, has been fuelled by the use of cheap energy from fossil fuel combustion. It has facilitated a dramatic rise in both the human population, now above 7 Billion with 50% now living in urban agglomerations, and its standard of living. It is anticipated that by 2050 there will be of the order of 8.3 to 10 billion people, 75% living in cities. Anthropogenic activity has resulted in pollution from the local to the global scale changes in land use, the destruction of stratospheric ozone, the modification of biogeochemical cycling, acid deposition, impacted on ecosystems and ecosystem services, destruction of biodiversity and climate change. The impact of man has moved the earth from the Holocene to the new geological epoch of the Anthropocene. To improve our understanding of the earth atmosphere system and the accuracy of the prediction of its future changes, knowledge of the amounts and distributions of trace atmospheric constituents are essential -“One cannot manage what is not measured”. An integrated observing system, comprising ground and space based segments is required to improve our science and to provide an evidence base needed for environmental policymakers. Passive remote sensing measurements made of the up-welling radiation at the top of the atmosphere from instrumentation on space borne platforms provide a unique opportunity to retrieve globally atmospheric composition. This presentation describes results from the SCIAMACHY (SCanning Imaging Absorption spectroMeter for Atmospheric CHartographY on ESA Envsiat 2002 to 2012) and its spin offs GOME (Global Ozone Monitoring Experiment ESA ERS-2 1995 to 2011) and GOME-2 (ESA/EUMETSAT Metop series). The potential of the SCIAMACHY successors Sentinel 5, CarbonSat, and SCIA-ISS will also be addressed.

The magnetic field of the earth - Performance considerations for space-based observing systems

Science.gov (United States)

Webster, W. J., Jr.; Taylor, P. T.; Schnetzler, C. C.; Langel, R. A.

1985-01-01

Basic problems inherent in carrying out observations of the earth magnetic field from space are reviewed. It is shown that while useful observations of the core and crustal fields are possible at the peak of the solar cycle, the greatest useful data volume is obtained during solar minimum. During the last three solar cycles, the proportion of data with a planetary disturbance index of less than 2 at solar maximum was in the range 0.4-0.8 in comparison with solar minimum. It is found that current state of the art orbit determination techniques should eliminate orbit error as a problem in gravitational field measurements from space. The spatial resolution obtained for crustal field anomalies during the major satellite observation programs of the last 30 years are compared in a table. The relationship between observing altitude and the spatial resolution of magnetic field structures is discussed. Reference is made to data obtained using the Magsat, the Polar Orbiting Geophysical Observatory (POGO), and instruments on board the Space Shuttle.

Earth observation space programmes, SAFISY activities, strategies of international organisations, legal aspects. Volume 3

International Nuclear Information System (INIS)

1992-01-01

This volume is separated in four sessions. First part is on earth observation space programmes (international earth observation projects and international collaboration, the ERS-1, SPOT and PRIRODA programmes, the first ESA earth observation polar platform and its payload, the future earth observation remote sensing techniques and concepts). The second part is on SAFISY activities (ISY programmes, education and applications, demonstrations and outreach projects). The third part is on programme and strategies of international organisations with respect to earth observation from space. The fourth part is on legal aspects of the use of satellite remote sensing data in Europe. (A.B.). refs., figs., tabs

CEOS contributions to informing energy management and policy decision making using space-based Earth observations

International Nuclear Information System (INIS)

Eckman, Richard S.; Stackhouse, Paul W.

2012-01-01

Earth observations are playing an increasingly significant role in informing decision making in the energy sector. In renewable energy applications, space-based observations now routinely augment sparse ground-based observations used as input for renewable energy resource assessment applications. As one of the nine Group on Earth Observations (GEO) societal benefit areas, the enhancement of management and policy decision making in the energy sector is receiving attention in activities conducted by the Committee on Earth Observation Satellites (CEOS). CEOS has become the “space arm” for the implementation of the Global Earth Observation System of Systems (GEOSS) vision. It is directly supporting the space-based, near-term tasks articulated in the GEO three-year work plan. This paper describes a coordinated program of demonstration projects conducted by CEOS member agencies and partners to utilize Earth observations to enhance energy management end-user decision support systems. We discuss the importance of engagement with stakeholders and understanding their decision support needs in successfully increasing the uptake of Earth observation products for societal benefit. Several case studies are presented, demonstrating the importance of providing data sets in formats and units familiar and immediately usable by decision makers. These projects show the utility of Earth observations to enhance renewable energy resource assessment in the developing world, forecast space weather impacts on the power grid, and improve energy efficiency in the built environment.

CEOS Contributions to Informing Energy Management and Policy Decision Making Using Space-Based Earth Observations

Science.gov (United States)

Eckman, Richard S.

2009-01-01

Earth observations are playing an increasingly significant role in informing decision making in the energy sector. In renewable energy applications, space-based observations now routinely augment sparse ground-based observations used as input for renewable energy resource assessment applications. As one of the nine Group on Earth Observations (GEO) societal benefit areas, the enhancement of management and policy decision making in the energy sector is receiving attention in activities conducted by the Committee on Earth Observation Satellites (CEOS). CEOS has become the "space arm" for the implementation of the Global Earth Observation System of Systems (GEOSS) vision. It is directly supporting the space-based, near-term tasks articulated in the GEO three-year work plan. This paper describes a coordinated program of demonstration projects conducted by CEOS member agencies and partners to utilize Earth observations to enhance energy management end-user decision support systems. I discuss the importance of engagement with stakeholders and understanding their decision support needs in successfully increasing the uptake of Earth observation products for societal benefit. Several case studies are presented, demonstrating the importance of providing data sets in formats and units familiar and immediately usable by decision makers. These projects show the utility of Earth observations to enhance renewable energy resource assessment in the developing world, forecast space-weather impacts on the power grid, and improve energy efficiency in the built environment.

A repeating fast radio burst.

Science.gov (United States)

Spitler, L G; Scholz, P; Hessels, J W T; Bogdanov, S; Brazier, A; Camilo, F; Chatterjee, S; Cordes, J M; Crawford, F; Deneva, J; Ferdman, R D; Freire, P C C; Kaspi, V M; Lazarus, P; Lynch, R; Madsen, E C; McLaughlin, M A; Patel, C; Ransom, S M; Seymour, A; Stairs, I H; Stappers, B W; van Leeuwen, J; Zhu, W W

2016-03-10

Fast radio bursts are millisecond-duration astronomical radio pulses of unknown physical origin that appear to come from extragalactic distances. Previous follow-up observations have failed to find additional bursts at the same dispersion measure (that is, the integrated column density of free electrons between source and telescope) and sky position as the original detections. The apparent non-repeating nature of these bursts has led to the suggestion that they originate in cataclysmic events. Here we report observations of ten additional bursts from the direction of the fast radio burst FRB 121102. These bursts have dispersion measures and sky positions consistent with the original burst. This unambiguously identifies FRB 121102 as repeating and demonstrates that its source survives the energetic events that cause the bursts. Additionally, the bursts from FRB 121102 show a wide range of spectral shapes that appear to be predominantly intrinsic to the source and which vary on timescales of minutes or less. Although there may be multiple physical origins for the population of fast radio bursts, these repeat bursts with high dispersion measure and variable spectra specifically seen from the direction of FRB 121102 support an origin in a young, highly magnetized, extragalactic neutron star.

Remote observing with NASA's Deep Space Network

Science.gov (United States)

Kuiper, T. B. H.; Majid, W. A.; Martinez, S.; Garcia-Miro, C.; Rizzo, J. R.

2012-09-01

The Deep Space Network (DSN) communicates with spacecraft as far away as the boundary between the Solar System and the interstellar medium. To make this possible, large sensitive antennas at Canberra, Australia, Goldstone, California, and Madrid, Spain, provide for constant communication with interplanetary missions. We describe the procedures for radioastronomical observations using this network. Remote access to science monitor and control computers by authorized observers is provided by two-factor authentication through a gateway at the Jet Propulsion Laboratory (JPL) in Pasadena. To make such observations practical, we have devised schemes based on SSH tunnels and distributed computing. At the very minimum, one can use SSH tunnels and VNC (Virtual Network Computing, a remote desktop software suite) to control the science hosts within the DSN Flight Operations network. In this way we have controlled up to three telescopes simultaneously. However, X-window updates can be slow and there are issues involving incompatible screen sizes and multi-screen displays. Consequently, we are now developing SSH tunnel-based schemes in which instrument control and monitoring, and intense data processing, are done on-site by the remote DSN hosts while data manipulation and graphical display are done at the observer's host. We describe our approaches to various challenges, our experience with what worked well and lessons learned, and directions for future development.

Environment monitoring from space

International Nuclear Information System (INIS)

Takagi, M.

1994-01-01

Environmental problems such as acid rain, ozone depletion, deforestation, erosion, and the greenhouse effect are of increasing concern, and continuous earth observation from artificial satellites has been contributing significant information on the environment since the 1960s. Earth observation from space has the advantages of wide area coverage at potentially high resolutions, periodic and long-term observation capability, data acquisition with uniform quality and repeatability, and ability to observe using different types of sensors. Problems to be solved in earth observation include the need for preprocessing of satellite data, understanding the relationship between observed physical parameters and objects, and the high volume of data for processing. In Japan, a research project on the higher-order utilization of remote sensing data from space was organized in 1985, and the results led to recognition of the importance of satellite observation. It was then decided to undertake a program to improve the understanding of the earth environment by satellite. Five research plans were selected: a basic study on earth observation by microwaves; global change analysis of the biosphere; a study of the physical process of the water cycle over land; a study of air-sea interaction; and higher-order processing of earth observation information. In recognition of the international nature of satellite data, as well as the capabilities of Canada and Japan in computer, communication, and multimedia technologies, bilateral cooperation is proposed in the area of earth environment information systems based on satellite observation

A phase-space approach to atmospheric dynamics based on observational data. Theory and applications

International Nuclear Information System (INIS)

Wang Risheng.

1994-01-01

This thesis is an attempt to develop systematically a phase-space approach to the atmospheric dynamics based on the theoretical achievement and application experiences in nonlinear time-series analysis. In particular, it is concerned with the derivation of quantities for describing the geometrical structure of the observed dynamics in phase-space (dimension estimation) and the examination of the observed atmospheric fluctuations in the light of phase-space representation. The thesis is, therefore composed of three major parts, i.e. an general survey of the theory of statistical approaches to dynamic systems, the methodology designed for the present study and specific applications with respect to dimension estimation and to a phase-space analysis of the tropical stratospheric quasi-biennial oscillation. (orig./KW)

A Network-Based Algorithm for Clustering Multivariate Repeated Measures Data

Science.gov (United States)

Koslovsky, Matthew; Arellano, John; Schaefer, Caroline; Feiveson, Alan; Young, Millennia; Lee, Stuart

2017-01-01

The National Aeronautics and Space Administration (NASA) Astronaut Corps is a unique occupational cohort for which vast amounts of measures data have been collected repeatedly in research or operational studies pre-, in-, and post-flight, as well as during multiple clinical care visits. In exploratory analyses aimed at generating hypotheses regarding physiological changes associated with spaceflight exposure, such as impaired vision, it is of interest to identify anomalies and trends across these expansive datasets. Multivariate clustering algorithms for repeated measures data may help parse the data to identify homogeneous groups of astronauts that have higher risks for a particular physiological change. However, available clustering methods may not be able to accommodate the complex data structures found in NASA data, since the methods often rely on strict model assumptions, require equally-spaced and balanced assessment times, cannot accommodate missing data or differing time scales across variables, and cannot process continuous and discrete data simultaneously. To fill this gap, we propose a network-based, multivariate clustering algorithm for repeated measures data that can be tailored to fit various research settings. Using simulated data, we demonstrate how our method can be used to identify patterns in complex data structures found in practice.

The effect of repeated testing vs repeated practice on skills learning in undergraduate dental education.

Science.gov (United States)

Sennhenn-Kirchner, S; Goerlich, Y; Kirchner, B; Notbohm, M; Schiekirka, S; Simmenroth, A; Raupach, T

2018-02-01

Recent studies in undergraduate medical education have demonstrated the advantage of repeated testing over repeated practice with regard to knowledge and skills retention. The aim of this study was to investigate whether this "testing effect" also applies to skills retention in undergraduate dental education. In this prospective, randomised controlled trial, fourth-year dental students at Göttingen University Medical Centre participated in a training session on surgical suturing in winter term 2014/2015. Following this, they were either assigned to two sessions of additional skills training (group A) or two sessions of skills assessment with feedback (group B). These sessions were spaced over a period of 4 weeks. Skills retention was assessed in a summative objective structured clinical examination (OSCE) at the end of term, that is 6 months after the initial teaching session. A total of 32 students completed the study. With regard to suturing, OSCE performance was significantly better in group B than group A (81.9±13.1% vs 63.0±15.4%; P=0.001; Cohen's d=1.33). There was no significant OSCE performance difference in the two groups with regard to other learning objectives that were addressed in the end-of-term examination. Thus, the group difference was specific to suturing skills. This is the first study to demonstrate that in dental education, repeated testing produces more favourable skills retention than repeated practice. Test-enhanced learning might be a viable concept for skills retention in undergraduate dentistry education. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Structure and state of repeatedly rubbed pure iron

Energy Technology Data Exchange (ETDEWEB)

Furuichi, Hiroshi [Dept. of Mechanical System Engineering, Yamanashi Univ., Kofu (Japan); Nakamura, Shoichiro [Dept. of Mechanical System Engineering, Yamanashi Univ., Kofu (Japan); Xuan Junsong [Nippo Precision Ltd., Nirasaki (Japan); Yamazaki, Kunihiro [Dept. of Mechanical System Engineering, Yamanashi Univ., Kofu (Japan)

1995-05-01

Pure iron was repeatedly rubbed under special conditions. The highest and the average hardness near the friction surface were 1431 HV and 1146 HV, respectively. Diffraction patterns near the friction surface showed a broad hexagonal ring corresponding to the (002) plane of {epsilon}-iron (hcp), although the other rings are from {alpha}-iron. Extremely fine imperfectly defined regions were observed from the area of this diffraction pattern. Another diffraction patterns showed an extremely diffuse and faint halo ring indicating an amorphous state, whose average atomic distance equals one of the interplanar spacing of the basal plane of {epsilon}-iron. This amorphous state differs from that by obtained rapid quenching. These results suggest that a structure with only the basal plane of {epsilon}-iron appeared during the rubbing and further destruction resulted in the amorphous state. Extremely high pressure may arise during rubbing: {epsilon}-iron forms above 13 GPa at room temperature and the basal plane consists of the shortest atomic distance of iron. In the latter pattern, a spot arrangement indicating a structure ordered only in one or two directions was observed. Rows of pits and cracks connecting them were observed, on the side surface near the rubbed surface, which shows crack formation during sliding contact fatigue. (orig.)

Atmospheric Variability of CO2 impact on space observation Requirements

Science.gov (United States)

Swanson, A. L.; Sen, B.; Newhart, L.; Segal, G.

2009-12-01

If International governments are to reduce GHG levels by 80% by 2050, as recommended by most scientific bodies concerned with avoiding the most hazardous changes in climate, then massive investments in infrastructure and new technology will be required over the coming decades. Such an investment will be a huge commitment by governments and corporations, and while it will offer long-term dividends in lower energy costs, a healthier environment and averted additional global warming, the shear magnitude of upfront costs will drive a call for a monitoring and verification system. Such a system will be required to offer accountability to signatories of governing bodies, as well as, for the global public. Measuring the average global distribution of CO2 is straight forward, as exemplified by the long running station measurements managed by NOAA’s Global Monitoring Division that includes the longterm Keeling record. However, quantifying anthropogenic and natural source/sink distributions and atmospheric mixing have been much more difficult to constrain. And, yet, an accurate accounting of all anthropogenic source strengths is required for Global Treaty verification. The only way to accurately assess Global GHG emissions is to construct an integrated system of ground, air and space based observations with extensive chemical modeling capabilities. We look at the measurement requirements for the space based component of the solutions. To determine what space sensor performance requirements for ground resolution, coverage, and revisit, we have analyzed regional CO2 distributions and variability using NASA and NOAA aircraft flight campaigns. The results of our analysis are presented as variograms showing average spatial variability over several Northern Hemispheric regions. There are distinct regional differences with the starkest contrast between urban versus rural and Coastal Asia versus Coastal US. The results suggest specific consequences on what spatial and temporal

FRB 121102: A Starquake-induced Repeater?

Science.gov (United States)

Wang, Weiyang; Luo, Rui; Yue, Han; Chen, Xuelei; Lee, Kejia; Xu, Renxin

2018-01-01

Since its initial discovery, the fast radio burst (FRB) FRB 121102 has been found to be repeating with millisecond-duration pulses. Very recently, 14 new bursts were detected by the Green Bank Telescope during its continuous monitoring observations. In this paper, we show that the burst energy distribution has a power-law form which is very similar to the Gutenberg–Richter law of earthquakes. In addition, the distribution of burst waiting time can be described as a Poissonian or Gaussian distribution, which is consistent with earthquakes, while the aftershock sequence exhibits some local correlations. These findings suggest that the repeating FRB pulses may originate from the starquakes of a pulsar. Noting that the soft gamma-ray repeaters (SGRs) also exhibit such distributions, the FRB could be powered by some starquake mechanisms associated with the SGRs, including the crustal activity of a magnetar or solidification-induced stress of a newborn strangeon star. These conjectures could be tested with more repeating samples.

Perspectives for Distributed Observations of Near-Earth Space Using a Russian-Cuban Observatory

Science.gov (United States)

Bisikalo, D. V.; Savanov, I. S.; Naroenkov, S. A.; Nalivkin, M. A.; Shugarov, A. S.; Bakhtigaraev, N. S.; Levkina, P. A.; Ibragimov, M. A.; Kil'pio, E. Yu.; Sachkov, M. E.; Kartashova, A. P.; Fateeva, A. M.; Uratsuka, Marta R. Rodriguez; Estrada, Ramses Zaldivar; Diaz, Antonio Alonsa; Rodríguez, Omar Pons; Figuera, Fidel Hernandes; Garcia, Maritza Garcia

2018-06-01

The creation of a specialized network of large, wide-angle telescopes for distributed observations of near-Earth space using a Russian-Cuban Observatory is considered. An extremely important goal of routine monitoring of near-Earth and near-Sun space is warding off threats with both natural and technogenic origins. Natural threats are associated with asteroids or comets, and technogenic threats with man-made debris in near-Earth space. A modern network of ground-based optical instruments designed to ward off such threats must: (a) have a global and, if possible, uniform geographic distribution, (b) be suitable for wide-angle, high-accuracy precision survey observations, and (c) be created and operated within a single network-oriented framework. Experience at the Institute of Astronomy on the development of one-meter-class wide-angle telescopes and elements of a super-wide-angle telescope cluster is applied to determine preferences for the composition of each node of such a network. The efficiency of distributed observations in attaining maximally accurate predictions of the motions of potentially dangerous celestial bodies as they approach the Earth and in observations of space debris and man-made satellites is estimated. The first estimates of astroclimatic conditions at the proposed site of the future Russian-Cuban Observatory in the mountains of the Sierra del Rosario Biosphere Reserve are obtained. Special attention is given to the possible use of the network to carry out a wide range of astrophysical studies, including optical support for the localization of gravitational waves and other transient events.

Repeat-aware modeling and correction of short read errors.

Science.gov (United States)

Yang, Xiao; Aluru, Srinivas; Dorman, Karin S

2011-02-15

High-throughput short read sequencing is revolutionizing genomics and systems biology research by enabling cost-effective deep coverage sequencing of genomes and transcriptomes. Error detection and correction are crucial to many short read sequencing applications including de novo genome sequencing, genome resequencing, and digital gene expression analysis. Short read error detection is typically carried out by counting the observed frequencies of kmers in reads and validating those with frequencies exceeding a threshold. In case of genomes with high repeat content, an erroneous kmer may be frequently observed if it has few nucleotide differences with valid kmers with multiple occurrences in the genome. Error detection and correction were mostly applied to genomes with low repeat content and this remains a challenging problem for genomes with high repeat content. We develop a statistical model and a computational method for error detection and correction in the presence of genomic repeats. We propose a method to infer genomic frequencies of kmers from their observed frequencies by analyzing the misread relationships among observed kmers. We also propose a method to estimate the threshold useful for validating kmers whose estimated genomic frequency exceeds the threshold. We demonstrate that superior error detection is achieved using these methods. Furthermore, we break away from the common assumption of uniformly distributed errors within a read, and provide a framework to model position-dependent error occurrence frequencies common to many short read platforms. Lastly, we achieve better error correction in genomes with high repeat content. The software is implemented in C++ and is freely available under GNU GPL3 license and Boost Software V1.0 license at "http://aluru-sun.ece.iastate.edu/doku.php?id = redeem". We introduce a statistical framework to model sequencing errors in next-generation reads, which led to promising results in detecting and correcting errors

On Solving Intransitivities in Repeated Pairwise Choices

NARCIS (Netherlands)

A. Maas (Arne); Th.G.G. Bezembinder (Thom); P.P. Wakker (Peter)

1995-01-01

textabstractAn operational method is presented for deriving a linear ranking of alternatives from repeated paired comparisons of the alternatives. Intransitivities in the observed preferences are cleared away by the introduction of decision errors of varying importance. An observed preference

Observing at-surface irradiance and albedo from space : The Tibet experiment

NARCIS (Netherlands)

Roupioz, L.

2015-01-01

Monitoring the solar radiation budget on a daily basis is a prerequisite to study land surface processes, especially in climatology and hydrology, and in derived applications like drought early warning. Current space-born radiometers can provide daily observations to derive surface radiative fluxes

Space Radiation Induced Cytogenetic Damage in the Blood Lymphocytes of Astronauts: Persistence of Damage After Flight and the Effects of Repeat Long Duration Missions

Science.gov (United States)

George, Kerry; Rhone, Jordan; Chappell, L. J.; Cucinotta, F. A.

2010-01-01

Cytogenetic damage was assessed in blood lymphocytes from astronauts before and after they participated in long-duration space missions of three months or more. The frequency of chromosome damage was measured by fluorescence in situ hybridization (FISH) chromosome painting before flight and at various intervals from a few days to many months after return from the mission. For all individuals, the frequency of chromosome exchanges measured within a month of return from space was higher than their prefight yield. However, some individuals showed a temporal decline in chromosome damage with time after flight. Statistical analysis using combined data for all astronauts indicated a significant overall decreasing trend in total chromosome exchanges with time after flight, although this trend was not seen for all astronauts and the yield of chromosome damage in some individuals actually increased with time after flight. The decreasing trend in total exchanges was slightly more significant when statistical analysis was restricted to data collected more than 220 days after return from flight. In addition, limited data on multiple flights show a lack of correlation between time in space and translocation yields. Data from three crewmembers who has participated in two separate long-duration space missions provide limited information on the effect of repeat flights and show a possible adaptive response to space radiation exposure.

Extreme covariant quantum observables in the case of an Abelian symmetry group and a transitive value space

International Nuclear Information System (INIS)

Haapasalo, Erkka Theodor; Pellonpaeae, Juha-Pekka

2011-01-01

We represent quantum observables as normalized positive operator valued measures and consider convex sets of observables which are covariant with respect to a unitary representation of a locally compact Abelian symmetry group G. The value space of such observables is a transitive G-space. We characterize the extreme points of covariant observables and also determine the covariant extreme points of the larger set of all quantum observables. The results are applied to position, position difference, and time observables.

Approaching control for tethered space robot based on disturbance observer using super twisting law

Science.gov (United States)

Hu, Yongxin; Huang, Panfeng; Meng, Zhongjie; Wang, Dongke; Lu, Yingbo

2018-05-01

Approaching control is a key mission for the tethered space robot to perform the task of removing space debris. But the uncertainties of the TSR such as the change of model parameter have an important effect on the approaching mission. Considering the space tether and the attitude of the gripper, the dynamic model of the TSR is derived using Lagrange method. Then a disturbance observer is designed to estimate the uncertainty based on STW control method. Using the disturbance observer, a controller is designed, and the performance is compared with the dynamic inverse controller which turns out that the proposed controller performs better. Numerical simulation validates the feasibility of the proposed controller on the position and attitude tracking of the TSR.

OGLE-2016-BLG-0168 Binary Microlensing Event: Prediction and Confirmation of the Microlens Parallax Effect from Space-based Observations

Energy Technology Data Exchange (ETDEWEB)

Shin, I.-G.; Yee, J. C.; Jung, Y. K. [Smithsonian Astrophysical Observatory, 60 Garden Street, Cambridge, MA 02138 (United States); Udalski, A.; Skowron, J.; Mróz, P.; Soszyński, I.; Poleski, R.; Szymański, M. K.; Kozłowski, S.; Pietrukowicz, P.; Ulaczyk, K.; Pawlak, M. [Warsaw University Observatory, Al. Ujazdowskie 4,00-478 Warszawa (Poland); Novati, S. Calchi [IPAC, Mail Code 100-22, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125 (United States); Han, C. [Department of Physics, Chungbuk National University, Cheongju 371-763 (Korea, Republic of); Albrow, M. D. [University of Canterbury, Department of Physics and Astronomy, Private Bag 4800, Christchurch 8020 (New Zealand); Gould, A. [Department of Astronomy, Ohio State University, 140 W. 18th Avenue, Columbus, OH 43210 (United States); Chung, S.-J.; Hwang, K.-H.; Ryu, Y.-H. [Korea Astronomy and Space Science Institute, 776 Daedeokdae-ro, Yuseong-Gu, Daejeon 34055 (Korea, Republic of); Collaboration: OGLE Collaboration; KMTNet Group; Spitzer Team; and others

2017-11-01

The microlens parallax is a crucial observable for conclusively identifying the nature of lens systems in microlensing events containing or composed of faint (even dark) astronomical objects such as planets, neutron stars, brown dwarfs, and black holes. With the commencement of a new era of microlensing in collaboration with space-based observations, the microlens parallax can be routinely measured. In addition, space-based observations can provide opportunities to verify the microlens parallax measured from ground-only observations and to find a unique solution to the lensing light-curve analysis. Furthermore, since most space-based observations cannot cover the full light curves of lensing events, it is also necessary to verify the reliability of the information extracted from fragmentary space-based light curves. We conduct a test based on the microlensing event OGLE-2016-BLG-0168, created by a binary lens system consisting of almost equal mass M-dwarf stars, to demonstrate that it is possible to verify the microlens parallax and to resolve degeneracies using the space-based light curve even though the observations are fragmentary. Since space-based observatories will frequently produce fragmentary light curves due to their short observing windows, the methodology of this test will be useful for next-generation microlensing experiments that combine space-based and ground-based collaboration.

A telescope for observation from space of extreme lightnings in the upper atmosphere

International Nuclear Information System (INIS)

Nam, S.; Artikova, S.; Chung, T.; Garipov, G.; Jeon, J.A.; Jeong, S.; Jin, J.Y.; Khrenov, B.A.; Kim, J.E.; Kim, M.; Kim, Y.K.; Klimov, P.; Lee, J.; Lee, H.Y.; Na, G.W.; Oh, S.J.; Panasyuk, M.; Park, I.H.; Park, J.H.; Park, Y.-S.

2008-01-01

A new type of telescope with a wide field-of-view and functions of fast zoom-in has been introduced. Two kinds of MEMS (Micro-Electro-Mechanical Systems) micromirrors, digital and analog, are used for reflectors of the telescope, placed at different focal lengths. We apply this technology to the observation from space of TLE (Transient Luminous Events), extremely large transient sparks occurring at the upper atmosphere. TLE are one type of important backgrounds to be understood for future space observation of UHECR (Ultra-High Energy Cosmic Rays). The launch of the payload carried by a Russian microsatellite is foreseen in the middle of 2008

A new space technology for ocean observation: the SMOS mission

Directory of Open Access Journals (Sweden)

Jordi Font

2012-09-01

Full Text Available Capability for sea surface salinity observation was an important gap in ocean remote sensing in the last few decades of the 20th century. New technological developments during the 1990s at the European Space Agency led to the proposal of SMOS (Soil Moisture and Ocean Salinity, an Earth explorer opportunity mission based on the use of a microwave interferometric radiometer, MIRAS (Microwave Imaging Radiometer with Aperture Synthesis. SMOS, the first satellite ever addressing the observation of ocean salinity from space, was successfully launched in November 2009. The determination of salinity from the MIRAS radiometric measurements at 1.4 GHz is a complex procedure that requires high performance from the instrument and accurate modelling of several physical processes that impact on the microwave emission of the ocean’s surface. This paper introduces SMOS in the ocean remote sensing context, and summarizes the MIRAS principles of operation and the SMOS salinity retrieval approach. It describes the Spanish SMOS high-level data processing centre (CP34 and the SMOS Barcelona Expert Centre on Radiometric Calibration and Ocean Salinity (SMOS-BEC, and presents a preliminary validation of global sea surface salinity maps operationally produced by CP34.

Using and Experiencing the Academic Library: A Multisite Observational Study of Space and Place

Science.gov (United States)

May, Francine; Swabey, Alice

2015-01-01

This study examines how students are using academic library spaces and the role these spaces are playing in the campus community. Data were collected on five campuses (two community colleges, two undergraduate universities, and one technical institute) via observational seating sweeps and questionnaires. The study found remarkably similar usage…

Quiet but still bright: XMM-Newton observations of the soft gamma-ray repeater SGR 0526-66

International Nuclear Information System (INIS)

Tiengo, A.; Esposito, P.; Mereghetti, S.; Esposito, P.; Israel, G.L.; Stella, L.; Turolla, R.; Turolla, R.; Zane, S.; Rea, N.; Gotz, D.; Feroci, M.

2009-01-01

SGR 0526-66 was the first soft gamma-ray repeater from which a giant flare was detected in 1979 March, suggesting the existence of magnetars, i.e. neutron stars powered by the decay of their extremely strong magnetic field. Since then, very little information has been obtained on this object, mainly because it has been burst inactive since 1983 and the study of its persistent X-ray emission has been hampered by its large distance and its location in a X-ray bright supernova remnant in the Large Magellanic Cloud. Here, we report on a comprehensive analysis of all the available XMM-Newton observations of SGR 0526-66. In particular, thanks to a deep observation taken in 2007, we measured its pulsation period (P = 8.0544 ± 0.0002 s) 6 years after its latest detection by Chandra. This allowed us to detect for the first time a significant reduction of its spin-down rate. From a comparison with two shorter XMM-Newton observations performed in 2000 and 2001, we found no significant changes in the spectrum, which is well modelled by an absorbed power law with nH = 4.6E+21 cm -2 and photon index = 3.27. The high luminosity about 4E+35 erg/s, in the 1-10 keV energy band) still observed about 25 years after the latest detection of bursting activity places SGR 0526-66 in the group of bright and persistent magnetar candidates. (authors)

Hubble Space Telescope: The Telescope, the Observations & the Servicing Mission

Science.gov (United States)

1999-11-01

Today the HST Archives contain more than 260 000 astronomical observations. More than 13 000 astronomical objects have been observed by hundreds of different groups of scientists. Direct proof of the scientific significance of this project is the record-breaking number of papers published : over 2400 to date. Some of HST's most memorable achievements are: * the discovery of myriads of very faint galaxies in the early Universe, * unprecedented, accurate measurements of distances to the farthest galaxies, * significant improvement in the determination of the Hubble constant and thus the age of the Universe, * confirmation of the existence of blacks holes, * a far better understanding of the birth, life and death of stars, * a very detailed look at the secrets of the process by which planets are created. Europe and HST ESA's contribution to HST represents a nominal investment of 15%. ESA provided one of the two imaging instruments - the Faint Object Camera (FOC) - and the solar panels. It also has 15 scientists and computer staff working at the Space Telescope Science Institute in Baltimore (Maryland). In Europe the astronomical community receives observational assistance from the Space Telescope European Coordinating Facility (ST-ECF) located in Garching, Munich. In return for ESA's investment, European astronomers have access to approximately 15% of the observing time. In reality the actual observing time competitively allocated to European astronomers is closer to 20%. Looking back at almost ten years of operation, the head of ST-ECF, European HST Project Scientist Piero Benvenuti states: "Hubble has been of paramount importance to European astronomy, much more than the mere 20% of observing time. It has given the opportunity for European scientists to use a top class instrument that Europe alone would not be able to build and operate. In specific areas of research they have now, mainly due to HST, achieved international leadership." One of the major reasons for

Observations of the Earth's magnetic field from the Space Station: Measurement at high and extremely low altitude using Space Station-controlled free-flyers

Science.gov (United States)

Webster, W., Jr.; Frawley, J. J.; Stefanik, M.

1984-01-01

Simulation studies established that the main (core), crustal and electrojet components of the Earth's magnetic field can be observed with greater resolution or over a longer time-base than is presently possible by using the capabilities provided by the space station. Two systems are studied. The first, a large lifetime, magnetic monitor would observe the main field and its time variation. The second, a remotely-piloted, magnetic probe would observe the crustal field at low altitude and the electrojet field in situ. The system design and the scientific performance of these systems is assessed. The advantages of the space station are reviewed.

AMPS sciences objectives and philosophy. [Atmospheric, Magnetospheric and Plasmas-in-Space project on Spacelab

Science.gov (United States)

Schmerling, E. R.

1975-01-01

The Space Shuttle will open a new era in the exploration of earth's near-space environment, where the weight and power capabilities of Spacelab and the ability to use man in real time add important new features. The Atmospheric, Magnetospheric, and Plasmas-in-Space project (AMPS) is conceived of as a facility where flexible core instruments can be flown repeatedly to perform different observations and experiments. The twin thrusts of remote sensing of the atmosphere below 120 km and active experiments on the space plasma are the major themes. They have broader implications in increasing our understanding of plasma physics and of energy conversion processes elsewhere in the universe.

Space Weather Monitoring for ISS Space Environments Engineering and Crew Auroral Observations

Science.gov (United States)

Minow, Joseph I.; Pettit, Donald R.; Hartman, William A.

2012-01-01

The awareness of potentially significant impacts of space weather on spaceand ground ]based technological systems has generated a strong desire in many sectors of government and industry to effectively transform knowledge and understanding of the variable space environment into useful tools and applications for use by those entities responsible for systems that may be vulnerable to space weather impacts. Essentially, effectively transitioning science knowledge to useful applications relevant to space weather has become important. This talk will present proven methodologies that have been demonstrated to be effective, and how in the current environment those can be applied to space weather transition efforts.

Manycore processing of repeated range queries over massive moving objects observations

DEFF Research Database (Denmark)

Lettich, Francesco; Orlando, Salvatore; Silvestri, Claudio

2014-01-01

decomposition and allows to tackle effectively a broad range of spatial object distributions, even those very skewed. Also, to deal with the architectural peculiarities and limitations of the GPUs, we adopt non-trivial GPU data structures that avoid the need of locked memory accesses and favour coalesced memory...... accesses, thus enhancing the overall memory throughput. To the best of our knowledge this is the first work that exploits GPUs to efficiently solve repeated range queries over massive sets of continuously moving objects, characterized by highly skewed spatial distributions. In comparison with state...

Solar System Observations with the James Webb Space Telescope

Science.gov (United States)

Norwood, James; Hammel, Heidi; Milam, Stefanie; Stansberry, John; Lunine, Jonathan; Chanover, Nancy; Hines, Dean; Sonneborn, George; Tiscareno, Matthew; Brown, Michael;

Cambridge observations at 38-115 MHz and their implications for space astronomy

International Nuclear Information System (INIS)

Saunders, R.

1987-01-01

The design and performance of the Cambridge LF telescopes are reviewed. Consideration is given to the 151-MHz 6C telescope, the 38-MHz and 151-MHz LF synthesis telescopes, 81.5-MHz interplanetary scintillation observations with the 3.6-hectare array, long-baseline interferometry at 81.5 MHz, and the use of the Jodrell Bank MERLIN for 151-MHz closure-phase observations of bright sources. The strict limitation on the field mappable at a given resolution in ground-based observations at these frequencies is pointed out, and some outstanding astronomical problems requiring 0.3-30-MHz space observations are listed. 7 references

The Critical Importance of Retrieval--and Spacing--for Learning.

Science.gov (United States)

Soderstrom, Nicholas C; Kerr, Tyson K; Bjork, Robert A

2016-02-01

We examined the impact of repeated testing and repeated studying on long-term learning. In Experiment 1, we replicated Karpicke and Roediger's (2008) influential results showing that once information can be recalled, repeated testing on that information enhances learning, whereas restudying that information does not. We then examined whether the apparent ineffectiveness of restudying might be attributable to the spacing differences between items that were inherent in the between-subjects design employed by Karpicke and Roediger. When we controlled for these spacing differences by manipulating the various learning conditions within subjects in Experiment 2, we found that both repeated testing and restudying improved learning, and that learners' awareness of the relative mnemonic benefits of these strategies was enhanced. These findings contribute to understanding how two important factors in learning-test-induced retrieval processes and spacing-can interact, and they illustrate that such interactions can play out differently in between-subjects and within-subjects experimental designs. © The Author(s) 2015.

State of Art in space weather observational activities and data management in Europe

Science.gov (United States)

Stanislawska, Iwona

One of the primary scientific and technical goals of space weather is to produce data in order to investigate the Sun impact on the Earth and its environment. Studies based on data mining philosophy yield increase the knowledge of space weather physical properties, modelling capabilities and gain applications of various procedures in space weather monitoring and forecasting. Exchanging tailored individually and/or jointly data between different entities, storing of the databases and making data accessible for the users is the most important task undertaken by investigators. National activities spread over Europe is currently consolidated pursuant to the terms of effectiveness and individual contributions embedded in joint integrated efforts. The role of COST 724 Action in animation of such a movement is essential. The paper focuses on the analysis of the European availability in the Internet near-real time and historical collections of the European ground based and satellite observations, operational indices and parameters. A detailed description of data delivered is included. The structure of the content is supplied according to the following selection: (1) observations, raw and/or corrected, updated data, (2) resolution, availability of real-time and historical data, (3) products, as the results of models and theory including (a) maps, forecasts and alerts, (b) resolution, availability of real-time and historical data, (4) platforms to deliver data. Characterization of the networking of stations, observatories and space related monitoring systems of data collections is integrated part of the paper. According to these provisions operational systems developed for these purposes is presented and analysed. It concerns measurements, observations and parameters from the theory and models referred to local, regional collections, European and worldwide networks. Techniques used by these organizations to generate the digital content are identified. As the reference pan

Fermi Coordinates of an Observer Moving in a Circle in Minkowski Space: Apparent Behavior of Clocks

National Research Council Canada - National Science Library

Bahder, Thomas

2000-01-01

Space-time coordinate transformations valid for arbitrarily long coordinate time are derived from global Minkowski coordinates to the Fermi coordinates of an observer moving in a circle in three-dimensional space...

Laboratory Observation of Electron Phase-Space Holes during Magnetic Reconnection

International Nuclear Information System (INIS)

Fox, W.; Porkolab, M.; Egedal, J.; Katz, N.; Le, A.

2008-01-01

We report the observation of large-amplitude, nonlinear electrostatic structures, identified as electron phase-space holes, during magnetic reconnection experiments on the Versatile Toroidal Facility at MIT. The holes are positive electric potential spikes, observed on high-bandwidth (∼2 GHz) Langmuir probes. Investigations with multiple probes establish that the holes travel at or above the electron thermal speed and have a three-dimensional, approximately spherical shape, with a scale size ∼2 mm. This corresponds to a few electron gyroradii, or many tens of Debye lengths, which is large compared to holes considered in simulations and observed by satellites, whose length scale is typically only a few Debye lengths. Finally, a statistical study over many discharges confirms that the holes appear in conjunction with the large inductive electric fields and the creation of energetic electrons associated with the magnetic energy release

Combustion of hydrogen/air/steam mixtures in a repeated obstacle field

International Nuclear Information System (INIS)

Kumar, R.K.; Bowles, E.M.; Koroll, G.W.

1994-01-01

Combustion experiments with hydrogen/air/steam mixtures were performed in a cylindrical vessel of 1.5-m internal diameter and 5.7-m height in a repeated obstacle field. The investigations included hydrogen concentrations in the range of 10 to 20% and steam concentrations of up to 30%. For the mixtures investigated, the flame accelerated very rapidly in the vessel, reached a peak value, and decelerated equally rapidly For hydrogen/air mixtures with hydrogen concentrations above 15%, the flame speeds reached values well in excess of the sonic velocity in the mixture. Addition of steam reduced the flame speed and the peak pressure, however, the reduction was significant only for steam concentrations >20%. Experiments performed with different obstacle spacings and flow blockages indicated that flame speed decreased with increased spacing and increased with increased blockage. The effect of initial pressure on flame speed was found to be small. For a given mixture, the peak flame speed was found to be independent of the igniter location. Simple empirical correlations have been proposed to calculate the flame speeds and peak pressures in a closed vessel with closely spaces repeated obstacles. (author)

Cyber space bullying

OpenAIRE

Popović-Ćitić Branislava

2009-01-01

Cyber space bullying is a relatively new phenomenon that has received increased attention by scientists, researchers and practitioners in recent years. It is usually defined as an intentionally and repeatedly expression of aggression towards other people through information and communication technologies. Cyber space bullying is characterized by all the primary characteristics of traditional bullying and some specifics ones that clearly differ it from other forms of bullying. In addition to t...

Exploring short-GRB afterglow parameter space for observations in coincidence with gravitational waves

Science.gov (United States)

Saleem, M.; Resmi, L.; Misra, Kuntal; Pai, Archana; Arun, K. G.

2018-03-01

Short duration Gamma Ray Bursts (SGRB) and their afterglows are among the most promising electromagnetic (EM) counterparts of Neutron Star (NS) mergers. The afterglow emission is broad-band, visible across the entire electromagnetic window from γ-ray to radio frequencies. The flux evolution in these frequencies is sensitive to the multidimensional afterglow physical parameter space. Observations of gravitational wave (GW) from BNS mergers in spatial and temporal coincidence with SGRB and associated afterglows can provide valuable constraints on afterglow physics. We run simulations of GW-detected BNS events and assuming that all of them are associated with a GRB jet which also produces an afterglow, investigate how detections or non-detections in X-ray, optical and radio frequencies can be influenced by the parameter space. We narrow down the regions of afterglow parameter space for a uniform top-hat jet model, which would result in different detection scenarios. We list inferences which can be drawn on the physics of GRB afterglows from multimessenger astronomy with coincident GW-EM observations.

Interrogating Key Positions of Size-Reduced TALE Repeats Reveals a Programmable Sensor of 5-Carboxylcytosine.

Science.gov (United States)

Maurer, Sara; Giess, Mario; Koch, Oliver; Summerer, Daniel

2016-12-16

Transcription-activator-like effector (TALE) proteins consist of concatenated repeats that recognize consecutive canonical nucleobases of DNA via the major groove in a programmable fashion. Since this groove displays unique chemical information for the four human epigenetic cytosine nucleobases, TALE repeats with epigenetic selectivity can be engineered, with potential to establish receptors for the programmable decoding of all human nucleobases. TALE repeats recognize nucleobases via key amino acids in a structurally conserved loop whose backbone is positioned very close to the cytosine 5-carbon. This complicates the engineering of selectivities for large 5-substituents. To interrogate a more promising structural space, we engineered size-reduced repeat loops, performed saturation mutagenesis of key positions, and screened a total of 200 repeat-nucleobase interactions for new selectivities. This provided insight into the structural requirements of TALE repeats for affinity and selectivity, revealed repeats with improved or relaxed selectivity, and resulted in the first selective sensor of 5-carboxylcytosine.

Observation planning algorithm of a Japanese space-borne sensor: Hyperspectral Imager SUIte (HISUI) onboard International Space Station (ISS) as platform

Science.gov (United States)

Ogawa, Kenta; Konno, Yukiko; Yamamoto, Satoru; Matsunaga, Tsuneo; Tachikawa, Tetsushi; Komoda, Mako

2017-09-01

Hyperspectral Imager Suite (HISUI) is a Japanese future space-borne hyperspectral instrument being developed by Ministry of Economy, Trade, and Industry (METI). HISUI will be launched in 2019 or later onboard International Space Station (ISS) as platform. HISUI has 185 spectral band from 0.4 to 2.5 μm with 20 by 30 m spatial resolution with swath of 20 km. Swath is limited as such, however observations in continental scale area are requested in HISUI mission lifetime of three years. Therefore we are developing a scheduling algorithm to generate effective observation plans. HISUI scheduling algorithm is to generate observation plans automatically based on platform orbit, observation area maps (we say DAR; "Data Acquisition Request" in HISUI project), their priorities, and available resources and limitation of HISUI system such as instrument operation time per orbit and data transfer capability. Then next we need to set adequate DAR before start of HISUI observation, because years of observations are needed to cover continental scale wide area that is difficult to change after the mission started. To address these issues, we have developed observation simulator. The simulator's critical inputs are DAR and the ISS's orbit, HISUI limitations in observation minutes per orbit, data storage and past cloud coverage data for term of HISUI observations (3 years). Then the outputs of simulator are coverage map of each day. Areas with cloud free image are accumulated for the term of observation up to three years. We have successfully tested the simulator and tentative DAR and found that it is possible to estimate coverage for each of requests for the mission lifetime.

Measurement of repeat effects in Chicago’s criminal social network

Directory of Open Access Journals (Sweden)

Paul Kump

2016-07-01

Full Text Available The “near-repeat” effect is a well-known criminological phenomenon in which the occurrence of a crime incident gives rise to a temporary elevation of crime risk within close physical proximity to an initial incident. Adopting a social network perspective, we instead define a near repeat in terms of geodesic distance within a criminal social network, rather than spatial distance. Specifically, we report a statistical analysis of repeat effects in arrest data for Chicago during the years 2003–2012. We divide the arrest data into two sets (violent crimes and other crimes and, for each set, we compare the distributions of time intervals between repeat incidents to theoretical distributions in which repeat incidents occur only by chance. We first consider the case of the same arrestee participating in repeat incidents (“exact repeats” and then extend the analysis to evaluate repeat risks of those arrestees near one another in the social network. We observe repeat effects that diminish as a function of geodesic distance and time interval, and we estimate typical time scales for repeat crimes in Chicago.

Observation of Atmospheric Constituents From Space

Science.gov (United States)

Burrows, J. P.

Remote sensing of the atmosphere from space is a growing research field. Surprisingly but for good physical reasons, the mesosphere and stratosphere are easier to probe from space than the troposphere. GOME (Global Ozone Monitoring Experiment) and SCIAMACHY (Scanning Imaging absorption spectroMeter for Atmospheric CHartographY) are related European instruments, which were proposed and been designed to measure atmospheric constituents (gases, aerosols and clouds) by passive remote sensing of the up-welling solar radiation leaving atmosphere. GOME is a smaller version of SCIAMACHY and was launched as part of the core payload of the second European research satellite (ERS-2) on the 20th April 1995. GOME comprises four spectral channels and measures simultaneously the earthshine radiance or solar extra terrestrial irradiance between 240 and 790 nm. Inversion of GOME measurements using the DOAS (Differential Optical Absorption Spectroscopy) yields the total column of trace gases (e.g. O3, NO2, HCHO, BrO and OClO). Application of the FURM (Full Retrieval Method) enables the profiles of O3 to be retrieved. One of the important achievements of GOME has been the separation of tropopsheirc columns of trace gases using TEM (Tropospheric Excess Method). SCIAMACHY has been developed as Germa n, Dutch and Belgian contribution to ENVISAT. It has significantly enhanced capability compared to GOME, measuring a larger spectral range, 220-2380 nm, and observing in alternate nadir and limb modes as well as solar and lunar occultation. ENVISAT is to be launched into a sun synchronous polar orbit, having an equator crossing time of 10.00 a.m. at the beginning of March 2002. SCIAMACHY is thereby able to measure many more species and vertical profiles than GOME. This facilitates improved tropospheric retrievals. Finally GeoTROPE (Geostationary TROPospheric Explorer) is a new mission, which is proposed for launch within the ESA Earth Explorer Opportunity Mission. It comprises two national

Global-scale Observations of the Limb and Disk (GOLD) Mission -Ultraviolet Remote Sensing of Earth's Space Environment from Geostationary Orbit

Science.gov (United States)

Burns, A. G.; Eastes, R.

2017-12-01

The GOLD mission of opportunity will fly a far ultraviolet imaging spectrograph in geostationary (GEO) orbit as a hosted payload. The mission is scheduled for launch in late January 2018 on SES-14, a commercial communications satellite that will be stationed over eastern South America at 47.5 degrees west longitude. GOLD is on schedule to be the first NASA science mission to fly as a hosted payload on a commercial communications satellite. The GOLD imager has two identical channels. Each channel can scan the full disk at a 30 minute cadence, making spectral images of Earth's UV emission from 132 to 162 nm, as well as make a measurement on the Earth's limb. Remote sensing techniques that have been proven on previous Low Earth Orbit (LEO) missions will be used to derive fundamental parameters for the neutral and ionized space environment. Parameters that will be derived include composition (O/N2 ratio) and temperature of the neutral atmosphere on the dayside disk. On the nightside, peak electron densities will be obtained in the low latitude ionosphere. Many of the algorithms developed for the mission are extensions of ones used on previous earth and planetary missions, with modifications for observations from geostationary orbit. All the algorithms have been tested using simulated observations based on the actual instrument performance. From geostationary orbit, GOLD can repeatedly image the same geographic locations over most of the hemisphere at a cadence comparable to that of the T-I system (order of an hour). Such time resolution and spatial coverage will allow the mission to track the changes due to geomagnetic storms, variations in solar extreme ultraviolet radiation, and forcing from the lower atmosphere. In addition to providing a new perspective by being able to repeatedly remotely sense the same hemisphere at a high cadence, GOLD's simultaneous measurements of not only composition but also temperatures across the disk will provide a valuable, new parameter

Integrating Satellite, Radar and Surface Observation with Time and Space Matching

Science.gov (United States)

Ho, Y.; Weber, J.

2015-12-01

The Integrated Data Viewer (IDV) from Unidata is a Java™-based software framework for analyzing and visualizing geoscience data. It brings together the ability to display and work with satellite imagery, gridded data, surface observations, balloon soundings, NWS WSR-88D Level II and Level III RADAR data, and NOAA National Profiler Network data, all within a unified interface. Applying time and space matching on the satellite, radar and surface observation datasets will automatically synchronize the display from different data sources and spatially subset to match the display area in the view window. These features allow the IDV users to effectively integrate these observations and provide 3 dimensional views of the weather system to better understand the underlying dynamics and physics of weather phenomena.

Scoring sensor observations to facilitate the exchange of space surveillance data

Science.gov (United States)

Weigel, M.; Fiedler, H.; Schildknecht, T.

2017-08-01

In this paper, a scoring metric for space surveillance sensor observations is introduced. A scoring metric allows for direct comparison of data quantity and data quality, and makes transparent the effort made by different sensor operators. The concept might be applied to various sensor types like tracking and surveillance radar, active optical laser tracking, or passive optical telescopes as well as combinations of different measurement types. For each measurement type, a polynomial least squares fit is performed on the measurement values contained in the track. The track score is the average sum over the polynomial coefficients uncertainties and scaled by reference measurement accuracy. Based on the newly developed scoring metric, an accounting model and a rating model are introduced. Both models facilitate the exchange of observation data within a network of space surveillance sensors operators. In this paper, optical observations are taken as an example for analysis purposes, but both models can also be utilized for any other type of observations. The rating model has the capability to distinguish between network participants with major and minor data contribution to the network. The level of sanction on data reception is defined by the participants themselves enabling a high flexibility. The more elaborated accounting model translates the track score to credit points earned for data provision and spend for data reception. In this model, data reception is automatically limited for participants with low contribution to the network. The introduced method for observation scoring is first applied for transparent data exchange within the Small Aperture Robotic Telescope Network (SMARTnet). Therefore a detailed mathematical description is presented for line of sight measurements from optical telescopes, as well as numerical simulations for different network setups.

First observations of iodine oxide from space

Science.gov (United States)

Saiz-Lopez, Alfonso; Chance, Kelly; Liu, Xiong; Kurosu, Thomas P.; Sander, Stanley P.

2007-06-01

We present retrievals of IO total columns from the Scanning Imaging Absorption Spectrometer for Atmospheric Chartography (SCIAMACHY) satellite instrument. We analyze data for October 2005 in the polar regions to demonstrate for the first time the capability to measure IO column abundances from space. During the period of analysis (i.e. Southern Hemisphere springtime), enhanced IO vertical columns over 3 × 1013 molecules cm-2 are observed around coastal Antarctica; by contrast during that time in the Artic region IO is consistently below the calculated instrumental detection limit for individual radiance spectra (2-4 × 1012 molecules cm-2 for slant columns). The levels reported here are in reasonably good agreement with previous ground-based measurements at coastal Antarctica. These results also demonstrate that IO is widespread over sea-ice covered areas in the Southern Ocean. The occurrence of elevated IO and its hitherto unrecognized spatial distribution suggest an efficient iodine activation mechanism at a synoptic scale over coastal Antarctica.

Observation of the Earth system from space

CERN Document Server

Flury, Jakob; Reigber, Christoph; Rothacher, Markus; Boedecker, Gerd

2006-01-01

In the recent years, space-based observation methods have led to a subst- tially improved understanding of Earth system. Geodesy and geophysics are contributing to this development by measuring the temporal and spatial va- ations of the Earth's shape, gravity ?eld, and magnetic ?eld, as well as at- sphere density. In the frame of the GermanR&D programmeGEOTECHNO- LOGIEN,researchprojectshavebeen launchedin2002relatedto the satellite missions CHAMP, GRACE and ESA's planned mission GOCE, to comp- mentary terrestrial and airborne sensor systems and to consistent and stable high-precision global reference systems for satellite and other techniques. In the initial 3-year phase of the research programme (2002-2004), new gravity ?eld models have been computed from CHAMP and GRACE data which outperform previous models in accuracy by up to two orders of m- nitude for the long and medium wavelengths. A special highlight is the - termination of seasonal gravity variations caused by changes in continental water masses...

Aviation & Space Weather Policy Research: Integrating Space Weather Observations & Forecasts into Operations

Science.gov (United States)

Fisher, G.; Jones, B.

2006-12-01

The American Meteorological Society and SolarMetrics Limited are conducting a policy research project leading to recommendations that will increase the safety, reliability, and efficiency of the nation's airline operations through more effective use of space weather forecasts and information. This study, which is funded by a 3-year National Science Foundation grant, also has the support of the Federal Aviation Administration and the Joint Planning and Development Office (JPDO) who is planning the Next Generation Air Transportation System. A major component involves interviewing and bringing together key people in the aviation industry who deal with space weather information. This research also examines public and industrial strategies and plans to respond to space weather information. The focus is to examine policy issues in implementing effective application of space weather services to the management of the nation's aviation system. The results from this project will provide government and industry leaders with additional tools and information to make effective decisions with respect to investments in space weather research and services. While space weather can impact the entire aviation industry, and this project will address national and international issues, the primary focus will be on developing a U.S. perspective for the airlines.

Does emotion modulate the efficacy of spaced learning in recognition memory?

OpenAIRE

Nicola Mammarella; Beth Fairfield; Alberto Di Domenico

2014-01-01

Memory for repeated items improves when presentations are spaced during study. Here, two experiments assessed the so-called spacing effect on a yes–no recognition memory task using affective and neutral words. In Experiment 1, a group of participants was asked to orient their attention to semantic features of target words (deep semantic analysis) that were consecutively repeated or spaced, while another group was engaged in a graphemic shallow analysis of words (Experiment 2). The depth of wo...

The COSPAR roadmap on Space-based observation and Integrated Earth System Science for 2016-2025

Science.gov (United States)

Fellous, Jean-Louis

2016-07-01

The Committee on Space Research of the International Council for Science recently commissioned a study group to prepare a roadmap on observation and integrated Earth-system science for the coming ten years. Its focus is on the combined use of observations and modelling to address the functioning, predictability and projected evolution of the Earth system on timescales out to a century or so. It discusses how observations support integrated Earth-system science and its applications, and identifies planned enhancements to the contributing observing systems and other requirements for observations and their processing. The paper will provide an overview of the content of the roadmap. All types of observation are considered in the roadmap, but emphasis is placed on those made from space. The origins and development of the integrated view of the Earth system are outlined, noting the interactions between the main components that lead to requirements for integrated science and modelling, and for the observations that guide and support them. What constitutes an Earth-system model is discussed. Summaries are given of key cycles within the Earth system. The nature of Earth observation and the arrangements for international coordination essential for effective operation of global observing systems are introduced in the roadmap. Instances are given of present types of observation, what is already on the roadmap for 2016-2025 and some of the issues to be faced. The current status and prospects for Earth-system modelling are summarized. Data assimilation is discussed not only because it uses observations and models to generate datasets for monitoring the Earth system and for initiating and evaluating predictions, in particular through reanalysis, but also because of the feedback it provides on the quality of both the observations and the models employed. Finally the roadmap offers a set of concluding discussions covering general developmental needs, requirements for continuity of

Image processing improvement for optical observations of space debris with the TAROT telescopes

Science.gov (United States)

Thiebaut, C.; Theron, S.; Richard, P.; Blanchet, G.; Klotz, A.; Boër, M.

2016-07-01

CNES is involved in the Inter-Agency Space Debris Coordination Committee (IADC) and is observing space debris with two robotic ground based fully automated telescopes called TAROT and operated by the CNRS. An image processing algorithm devoted to debris detection in geostationary orbit is implemented in the standard pipeline. Nevertheless, this algorithm is unable to deal with debris tracking mode images, this mode being the preferred one for debris detectability. We present an algorithm improvement for this mode and give results in terms of false detection rate.

Ground and space observations of medium frequency auroral radio emissions

Science.gov (United States)

Broughton, Matthew C.

The auroral zone is a rich source of natural radio emissions that can be observed in space and at ground-level. By studying these waves, scientists can gain insight into the plasma processes that generate them and use the near-Earth space environment as a large-scale plasma physics laboratory. This thesis uses both ground-level and in situ observations to study two kinds of natural radio emissions. First, we report observations of a new kind of auroral radio emission. The waves have frequencies ranging from 1.3-2.2 MHz, bandwidths ranging from 90-272 kHz, and durations ranging from 16-355 s. Spectral analysis of the waveform data has revealed that the emission has a complex combination of at least three kinds of fine structures. For model auroral electron distributions, calculations indicate that Langmuir waves could be excited at frequencies consistent with observations. The remainder of the thesis discusses auroral medium frequency (MF) burst, an impulsive, broadband natural radio emission observed at ground-level within a few minutes of local substorm onset. LaBelle [2011] proposed that MF burst originates as Langmuir/Z-mode waves on the topside of the ionosphere that subsequently mode convert to L-mode waves and propagate to ground-level. Using continuous waveform measurements and combined observations with the Sondrestrom Incoherent Scatter Radar, we have performed two tests of this mechanism. The results of these tests are consistent with the mechanism described in LaBelle [2011]. A survey of 8,624 half-orbits of the DEMETER spacecraft has revealed 68 observations of bursty MF waves. We have compared the wave properties of these waves to those of MF burst and have found that although it is uncertain, the balance of the evidence suggests that the bursty MF waves observed with DEMETER are the same phenomenon as the ground-level MF burst. Finally, we have used numerical simulations to model both the fine structure of MF burst and to estimate the attenuation the

Repeated radiation injuries by fission products

International Nuclear Information System (INIS)

Vasilenko, I.Ya.

1986-01-01

Attention is given to repeated radiation injuries during internal irradiation of theoretical and practical interest, particularly in case of the intake into organism of young products of nuclear fission (PNF). The results of experiments with dogs with repeated radioactive iodine injury the isotopes of which (131-135sub(I)) constitute a considerable part of PNF activity are discussed. The blood reaction and protein metabolism state have been studied. Observations for dogs have been continued for about 4 years. The doses for thyroid, gastrointestinal tract and liver subjected to the most intensive irradiation consituted in the first series of experiments after the first intake about 3;0.3;0.05 Gy, after the second - 5;0.5;0.08 Gy and in the second series of experiments - 3;0.3;0.05 Gy and 0.6;0.06;0.01 Gy, respectively. Hematologic factors,thyroid function, changes in exchange and immunologic reactivity have been studied. The dogs have been under observation for 5 years. It is shown in case of repeated intake of Isup(131) PNF into animals organism in quantity which does not cause during the acute period a clinically outlined sickness, substantial differences in the organism reaction as compared with the first intake of radionuclides have not been found. The presence of residual radiation injuries did not cause charging action during the acute period during PNF and repeated intake which in the author's opinion testifies to perfection of compensator mechanisms in case of intake of such quantities of radioactive products. At the remote periods blastomogenic action manifested which is estimated as a result of general biological action of radionuclides administered to the organism. The necessity in subsequent investigations for obtaining the data on organism reactivity, clinic and pathogenesis with the aim of prophylaxis and treatment of such injuries is indicated

Repeated swim stress alters brain benzodiazepine receptors measured in vivo

International Nuclear Information System (INIS)

Weizman, R.; Weizman, A.; Kook, K.A.; Vocci, F.; Deutsch, S.I.; Paul, S.M.

1989-01-01

The effects of repeated swim stress on brain benzodiazepine receptors were examined in the mouse using both an in vivo and in vitro binding method. Specific in vivo binding of [ 3 H]Ro15-1788 to benzodiazepine receptors was decreased in the hippocampus, cerebral cortex, hypothalamus, midbrain and striatum after repeated swim stress (7 consecutive days of daily swim stress) when compared to nonstressed mice. In vivo benzodiazepine receptor binding was unaltered after repeated swim stress in the cerebellum and pons medulla. The stress-induced reduction in in vivo benzodiazepine receptor binding did not appear to be due to altered cerebral blood flow or to an alteration in benzodiazepine metabolism or biodistribution because there was no difference in [14C]iodoantipyrine distribution or whole brain concentrations of clonazepam after repeated swim stress. Saturation binding experiments revealed a change in both apparent maximal binding capacity and affinity after repeated swim stress. Moreover, a reduction in clonazepam's anticonvulsant potency was also observed after repeated swim stress [an increase in the ED50 dose for protection against pentylenetetrazol-induced seizures], although there was no difference in pentylenetetrazol-induced seizure threshold between the two groups. In contrast to the results obtained in vivo, no change in benzodiazepine receptor binding kinetics was observed using the in vitro binding method. These data suggest that environmental stress can alter the binding parameters of the benzodiazepine receptor and that the in vivo and in vitro binding methods can yield substantially different results

Repeated swim stress alters brain benzodiazepine receptors measured in vivo

Energy Technology Data Exchange (ETDEWEB)

Weizman, R.; Weizman, A.; Kook, K.A.; Vocci, F.; Deutsch, S.I.; Paul, S.M.

1989-06-01

The effects of repeated swim stress on brain benzodiazepine receptors were examined in the mouse using both an in vivo and in vitro binding method. Specific in vivo binding of (/sup 3/H)Ro15-1788 to benzodiazepine receptors was decreased in the hippocampus, cerebral cortex, hypothalamus, midbrain and striatum after repeated swim stress (7 consecutive days of daily swim stress) when compared to nonstressed mice. In vivo benzodiazepine receptor binding was unaltered after repeated swim stress in the cerebellum and pons medulla. The stress-induced reduction in in vivo benzodiazepine receptor binding did not appear to be due to altered cerebral blood flow or to an alteration in benzodiazepine metabolism or biodistribution because there was no difference in (14C)iodoantipyrine distribution or whole brain concentrations of clonazepam after repeated swim stress. Saturation binding experiments revealed a change in both apparent maximal binding capacity and affinity after repeated swim stress. Moreover, a reduction in clonazepam's anticonvulsant potency was also observed after repeated swim stress (an increase in the ED50 dose for protection against pentylenetetrazol-induced seizures), although there was no difference in pentylenetetrazol-induced seizure threshold between the two groups. In contrast to the results obtained in vivo, no change in benzodiazepine receptor binding kinetics was observed using the in vitro binding method. These data suggest that environmental stress can alter the binding parameters of the benzodiazepine receptor and that the in vivo and in vitro binding methods can yield substantially different results.

Batman flies: a compact spectro-imager for space observation

Science.gov (United States)

Zamkotsian, Frederic; Ilbert, Olivier; Zoubian, Julien; Delsanti, Audrey; Boissier, Samuel; Lancon, Ariane

2017-11-01

Multi-object spectroscopy (MOS) is a key technique for large field of view surveys. MOEMS programmable slit masks could be next-generation devices for selecting objects in future infrared astronomical instrumentation for space telescopes. MOS is used extensively to investigate astronomical objects by optimizing the Signal-to-Noise Ratio (SNR): high precision spectra are obtained and the problem of spectral confusion and background level occurring in slitless spectroscopy is cancelled. Fainter limiting fluxes are reached and the scientific return is maximized both in cosmology and in legacy science. Major telescopes around the world are equipped with MOS in order to simultaneously record several hundred spectra in a single observation run. Next generation MOS for space like the Near Infrared Multi-Object Spectrograph (NIRSpec) for the James Webb Space Telescope (JWST) require a programmable multi-slit mask. Conventional masks or complex fiber-optics-based mechanisms are not attractive for space. The programmable multi-slit mask requires remote control of the multislit configuration in real time. During the early-phase studies of the European Space Agency (ESA) EUCLID mission, a MOS instrument based on a MOEMS device has been assessed. Due to complexity and cost reasons, slitless spectroscopy was chosen for EUCLID, despite a much higher efficiency with slit spectroscopy. A promising possible solution is the use of MOEMS devices such as micromirror arrays (MMA) [1,2,3] or micro-shutter arrays (MSA) [4]. MMAs are designed for generating reflecting slits, while MSAs generate transmissive slits. In Europe an effort is currently under way to develop single-crystalline silicon micromirror arrays for future generation infrared multi-object spectroscopy (collaboration LAM / EPFL-CSEM) [5,6]. By placing the programmable slit mask in the focal plane of the telescope, the light from selected objects is directed toward the spectrograph, while the light from other objects and

Learning characteristics of a space-time neural network as a tether skiprope observer

Science.gov (United States)

Lea, Robert N.; Villarreal, James A.; Jani, Yashvant; Copeland, Charles

1993-01-01

The Software Technology Laboratory at the Johnson Space Center is testing a Space Time Neural Network (STNN) for observing tether oscillations present during retrieval of a tethered satellite. Proper identification of tether oscillations, known as 'skiprope' motion, is vital to safe retrieval of the tethered satellite. Our studies indicate that STNN has certain learning characteristics that must be understood properly to utilize this type of neural network for the tethered satellite problem. We present our findings on the learning characteristics including a learning rate versus momentum performance table.

Large Torque Variations in Two Soft Gamma Repeaters

NARCIS (Netherlands)

Woods, P.M.; Kouveliotou, C.; Göğüş, E.; Finger, M.H.; Swank, J.; Markwardt, C.B.; Hurley, K.; van der Klis, M.

2002-01-01

We have monitored the pulse frequencies of the two soft gamma repeaters SGR 1806-20 and SGR 1900+14 through the beginning of year 2001 using primarily Rossi X-Ray Timing Explorer Proportional Counter Array observations. In both sources, we observe large changes in the spin-down torque up to a factor

Safety of Repeated Yttrium-90 Radioembolization

International Nuclear Information System (INIS)

Lam, Marnix G. E. H.; Louie, John D.; Iagaru, Andrei H.; Goris, Michael L.; Sze, Daniel Y.

2013-01-01

Purpose: Repeated radioembolization (RE) treatments carry theoretically higher risk of radiation-induced hepatic injury because of the liver’s cumulative memory of previous exposure. We performed a retrospective safety analysis on patients who underwent repeated RE. Methods: From 2004 to 2011, a total of 247 patients were treated by RE. Eight patients (5 men, 3 women, age range 51–71 years) underwent repeated treatment of a targeted territory, all with resin microspheres (SIR-Spheres; Sirtex, Lane Cove, Australia). Adverse events were graded during a standardized follow-up. In addition, the correlation between the occurrence of RE-induced liver disease (REILD) and multiple variables was investigated in univariate and multivariate analyses in all 247 patients who received RE. Results: Two patients died shortly after the second treatment (at 84 and 107 days) with signs and symptoms of REILD. Both patients underwent whole liver treatment twice (cumulative doses 3.08 and 2.66 GBq). The other 6 patients demonstrated only minor toxicities after receiving cumulative doses ranging from 2.41 to 3.88 GBq. All patients experienced objective tumor responses. In the whole population, multifactorial analysis identified three risk factors associated with REILD: repeated RE (p = 0.036), baseline serum total bilirubin (p = 0.048), and baseline serum aspartate aminotransferase (p = 0.043). Repeated RE proved to be the only independent risk factor for REILD in multivariate analysis (odds ratio 9.6; p = 0.002). Additionally, the administered activity per target volume (in GBq/L) was found to be an independent risk factor for REILD, but only in whole liver treatments (p = 0.033). Conclusion: The risk of REILD appears to be elevated for repeated RE. Objective tumor responses were observed, but establishment of safety limits will require improvement in dosimetric measurement and prediction

Safety of Repeated Yttrium-90 Radioembolization

Energy Technology Data Exchange (ETDEWEB)

Lam, Marnix G. E. H.; Louie, John D. [Stanford University School of Medicine, Division of Interventional Radiology (United States); Iagaru, Andrei H.; Goris, Michael L. [Stanford University School of Medicine, Division of Nuclear Medicine (United States); Sze, Daniel Y., E-mail: dansze@stanford.edu [Stanford University School of Medicine, Division of Interventional Radiology (United States)

2013-10-15

Purpose: Repeated radioembolization (RE) treatments carry theoretically higher risk of radiation-induced hepatic injury because of the liver's cumulative memory of previous exposure. We performed a retrospective safety analysis on patients who underwent repeated RE. Methods: From 2004 to 2011, a total of 247 patients were treated by RE. Eight patients (5 men, 3 women, age range 51-71 years) underwent repeated treatment of a targeted territory, all with resin microspheres (SIR-Spheres; Sirtex, Lane Cove, Australia). Adverse events were graded during a standardized follow-up. In addition, the correlation between the occurrence of RE-induced liver disease (REILD) and multiple variables was investigated in univariate and multivariate analyses in all 247 patients who received RE. Results: Two patients died shortly after the second treatment (at 84 and 107 days) with signs and symptoms of REILD. Both patients underwent whole liver treatment twice (cumulative doses 3.08 and 2.66 GBq). The other 6 patients demonstrated only minor toxicities after receiving cumulative doses ranging from 2.41 to 3.88 GBq. All patients experienced objective tumor responses. In the whole population, multifactorial analysis identified three risk factors associated with REILD: repeated RE (p = 0.036), baseline serum total bilirubin (p = 0.048), and baseline serum aspartate aminotransferase (p = 0.043). Repeated RE proved to be the only independent risk factor for REILD in multivariate analysis (odds ratio 9.6; p = 0.002). Additionally, the administered activity per target volume (in GBq/L) was found to be an independent risk factor for REILD, but only in whole liver treatments (p = 0.033). Conclusion: The risk of REILD appears to be elevated for repeated RE. Objective tumor responses were observed, but establishment of safety limits will require improvement in dosimetric measurement and prediction.

CIMEX: a prototype Instrument to observe from space the amazon forest In the near and shortwave infrared

Science.gov (United States)

Guerin, François; Dantes, Didier; Savaria, Eric; Selingardi, Mario Luis; Montes, Amauri Silva

2018-04-01

This paper, "CIMEX: a prototype Instrument to observe from space the amazon forest In the near and shortwave infrared," was presented as part of International Conference on Space Optics—ICSO 1997, held in Toulouse, France.

Computing security strategies in finite horizon repeated Bayesian games

KAUST Repository

Lichun Li

2017-07-10

This paper studies security strategies in two-player zero-sum repeated Bayesian games with finite horizon. In such games, each player has a private type which is independently chosen according to a publicly known a priori probability. Players\\' types are fixed all through the game. The game is played for finite stages. At every stage, players simultaneously choose their actions which are observed by the public. The one-stage payoff of player 1 (or penalty to player 2) depends on both players types and actions, and is not directly observed by any player. While player 1 aims to maximize the total payoff over the game, player 2 wants to minimize it. This paper provides each player two ways to compute the security strategy, i.e. the optimal strategy in the worst case. First, a security strategy that directly depends on both players\\' history actions is derived by refining the sequence form. Noticing that history action space grows exponentially with respect to the time horizon, this paper further presents a security strategy that depends on player\\'s fixed sized sufficient statistics. The sufficient statistics is shown to consist of the belief on one\\'s own type, the regret on the other player\\'s type, and the stage, and is independent of the other player\\'s strategy.

Hubble space telescope: The GO and GTO observing programs, version 3.0

Science.gov (United States)

Downes, Ron

1992-01-01

A portion of the observing time with the Hubble Space Telescope (HST) was awarded by NASA to scientists involved in the development of the HST and its instruments. These scientists are the Guaranteed Time Observers (GTO's). Observing time was also awarded to General Observers (GO's) on the basis of the proposal reviews in 1989 and 1991. The majority of the 1989 programs have been completed during 'Cycle 1', while the 1991 programs will be completed during 'Cycle 2', nominally a 12-month period beginning July 1992. This document presents abstracts of these GO and GTO programs, and detailed listings of the specific targets and exposures contained in them. These programs and exposures are protected by NASA policy, as detailed in the HST Call for Proposals (CP), and are not to be duplicated by new programs.

Large micro-mirror arrays: key components in future space instruments for Universe and Earth Observation

Directory of Open Access Journals (Sweden)

Zamkotsian Frederic

2015-01-01

Full Text Available In future space missions for Universe and Earth Observation, scientific return could be optimized using MOEMS devices. Micro-mirror arrays are used for designing new generation of instruments, multi-object spectrographs in Universe Observation and programmable wide field spectrographs in Earth Observation. Mock-ups have been designed and built for both applications and they show very promising results.

StreakDet data processing and analysis pipeline for space debris optical observations

Science.gov (United States)

Virtanen, Jenni; Flohrer, Tim; Muinonen, Karri; Granvik, Mikael; Torppa, Johanna; Poikonen, Jonne; Lehti, Jussi; Santti, Tero; Komulainen, Tuomo; Naranen, Jyri

We describe a novel data processing and analysis pipeline for optical observations of space debris. The monitoring of space object populations requires reliable acquisition of observational data, to support the development and validation of space debris environment models, the build-up and maintenance of a catalogue of orbital elements. In addition, data is needed for the assessment of conjunction events and for the support of contingency situations or launches. The currently available, mature image processing algorithms for detection and astrometric reduction of optical data cover objects that cross the sensor field-of-view comparably slowly, and within a rather narrow, predefined range of angular velocities. By applying specific tracking techniques, the objects appear point-like or as short trails in the exposures. However, the general survey scenario is always a “track before detect” problem, resulting in streaks, i.e., object trails of arbitrary lengths, in the images. The scope of the ESA-funded StreakDet (Streak detection and astrometric reduction) project is to investigate solutions for detecting and reducing streaks from optical images, particularly in the low signal-to-noise ratio (SNR) domain, where algorithms are not readily available yet. For long streaks, the challenge is to extract precise position information and related registered epochs with sufficient precision. Although some considerations for low-SNR processing of streak-like features are available in the current image processing and computer vision literature, there is a need to discuss and compare these approaches for space debris analysis, in order to develop and evaluate prototype implementations. In the StreakDet project, we develop algorithms applicable to single images (as compared to consecutive frames of the same field) obtained with any observing scenario, including space-based surveys and both low- and high-altitude populations. The proposed processing pipeline starts from the

Space Suit Joint Torque Testing

Science.gov (United States)

Valish, Dana J.

2011-01-01

In 2009 and early 2010, a test was performed to quantify the torque required to manipulate joints in several existing operational and prototype space suits in an effort to develop joint torque requirements appropriate for a new Constellation Program space suit system. The same test method was levied on the Constellation space suit contractors to verify that their suit design meets the requirements. However, because the original test was set up and conducted by a single test operator there was some question as to whether this method was repeatable enough to be considered a standard verification method for Constellation or other future space suits. In order to validate the method itself, a representative subset of the previous test was repeated, using the same information that would be available to space suit contractors, but set up and conducted by someone not familiar with the previous test. The resultant data was compared using graphical and statistical analysis and a variance in torque values for some of the tested joints was apparent. Potential variables that could have affected the data were identified and re-testing was conducted in an attempt to eliminate these variables. The results of the retest will be used to determine if further testing and modification is necessary before the method can be validated.

Simulations of VLBI observations of a geodetic satellite providing co-location in space

Science.gov (United States)

Anderson, James M.; Beyerle, Georg; Glaser, Susanne; Liu, Li; Männel, Benjamin; Nilsson, Tobias; Heinkelmann, Robert; Schuh, Harald

2018-02-01

We performed Monte Carlo simulations of very-long-baseline interferometry (VLBI) observations of Earth-orbiting satellites incorporating co-located space-geodetic instruments in order to study how well the VLBI frame and the spacecraft frame can be tied using such measurements. We simulated observations of spacecraft by VLBI observations, time-of-flight (TOF) measurements using a time-encoded signal in the spacecraft transmission, similar in concept to precise point positioning, and differential VLBI (D-VLBI) observations using angularly nearby quasar calibrators to compare their relative performance. We used the proposed European Geodetic Reference Antenna in Space (E-GRASP) mission as an initial test case for our software. We found that the standard VLBI technique is limited, in part, by the present lack of knowledge of the absolute offset of VLBI time to Coordinated Universal Time at the level of microseconds. TOF measurements are better able to overcome this problem and provide frame ties with uncertainties in translation and scale nearly a factor of three smaller than those yielded from VLBI measurements. If the absolute time offset issue can be resolved by external means, the VLBI results can be significantly improved and can come close to providing 1 mm accuracy in the frame tie parameters. D-VLBI observations with optimum performance assumptions provide roughly a factor of two higher uncertainties for the E-GRASP orbit. We additionally simulated how station and spacecraft position offsets affect the frame tie performance.

On the possibility of space objects invasion observations into the Earth's atmosphere with the help of a multifunctional polarimeter

Science.gov (United States)

Nevodovskyi, P. V.; Steklov, A. F.; Vidmachenko, A. P.

2018-05-01

Relevance of the tasks associated with the observation of the invasion of space objects into the Earth's atmosphere increases with each passing year. We used astronomical panoramic polarimeter for carrying out of polarimetric observations of objects, that flying into the atmosphere of the Earth from the surrounding outer space.

Cyber space bullying

Directory of Open Access Journals (Sweden)

Popović-Ćitić Branislava

2009-01-01

Full Text Available Cyber space bullying is a relatively new phenomenon that has received increased attention by scientists, researchers and practitioners in recent years. It is usually defined as an intentionally and repeatedly expression of aggression towards other people through information and communication technologies. Cyber space bullying is characterized by all the primary characteristics of traditional bullying and some specifics ones that clearly differ it from other forms of bullying. In addition to the analysis of characteristics and specifics of cyber space bullying, the paper describes the basic forms of cyber space bullying (flaming, harassment, denigration, impersonation, outing, trickery, exclusion, stalking and happy slapping, as well as, the types of cyber space bullies (vengeful angel, power-hungry, revenge of the nerd, mean girls and inadvertent. The main goal of this paper is to provide initial theoretical guidelines for designing future empirical research on the complex phenomenon of cyber space bullying.

Failure mode and effect analysis on safety critical components of space travel

OpenAIRE

Kouroush Jenab; Joseph Pineau

2015-01-01

Sending men to space has never been an ordinary activity, it requires years of planning and preparation in order to have a chance of success. The payoffs of reliable and repeatable space flight are many, including both Commercial and Military opportunities. In order for reliable and repeatable space flight to become a reality, catastrophic failures need to be detected and mitigated before they occur. It can be shown that small pieces of a design which seem ordinary can create devastating impa...

Repeated morphine treatment influences operant and spatial learning differentially

Institute of Scientific and Technical Information of China (English)

Mei-Na WANG; Zhi-Fang DONG; Jun CAO; Lin XU

2006-01-01

Objective To investigate whether repeated morphine exposure or prolonged withdrawal could influence operant and spatial learning differentially. Methods Animals were chronically treated with morphine or subjected to morphine withdrawal. Then, they were subjected to two kinds of learning: operant conditioning and spatial learning.Results The acquisition of both simple appetitive and cued operant learning was impaired after repeated morphine treatment. Withdrawal for 5 weeks alleviated the impairments. Single morphine exposure disrupted the retrieval of operant memory but had no effect on rats after 5-week withdrawal. Contrarily, neither chronic morphine exposure nor 5-week withdrawal influenced spatial learning task of the Morris water maze. Nevertheless, the retrieval of spatial memory was impaired by repeated morphine exposure but not by 5-week withdrawal. Conclusion These observations suggest that repeated morphine exposure can influence different types of learning at different aspects, implicating that the formation of opiate addiction may usurp memory mechanisms differentially.

A new technique for observationally derived boundary conditions for space weather

Science.gov (United States)

Pagano, Paolo; Mackay, Duncan Hendry; Yeates, Anthony Robinson

2018-04-01

Context. In recent years, space weather research has focused on developing modelling techniques to predict the arrival time and properties of coronal mass ejections (CMEs) at the Earth. The aim of this paper is to propose a new modelling technique suitable for the next generation of Space Weather predictive tools that is both efficient and accurate. The aim of the new approach is to provide interplanetary space weather forecasting models with accurate time dependent boundary conditions of erupting magnetic flux ropes in the upper solar corona. Methods: To produce boundary conditions, we couple two different modelling techniques, MHD simulations and a quasi-static non-potential evolution model. Both are applied on a spatial domain that covers the entire solar surface, although they extend over a different radial distance. The non-potential model uses a time series of observed synoptic magnetograms to drive the non-potential quasi-static evolution of the coronal magnetic field. This allows us to follow the formation and loss of equilibrium of magnetic flux ropes. Following this a MHD simulation captures the dynamic evolution of the erupting flux rope, when it is ejected into interplanetary space. Results.The present paper focuses on the MHD simulations that follow the ejection of magnetic flux ropes to 4 R⊙. We first propose a technique for specifying the pre-eruptive plasma properties in the corona. Next, time dependent MHD simulations describe the ejection of two magnetic flux ropes, that produce time dependent boundary conditions for the magnetic field and plasma at 4 R⊙ that in future may be applied to interplanetary space weather prediction models. Conclusions: In the present paper, we show that the dual use of quasi-static non-potential magnetic field simulations and full time dependent MHD simulations can produce realistic inhomogeneous boundary conditions for space weather forecasting tools. Before a fully operational model can be produced there are a

Observations of interplanetary scintillation and their application to the space weather forecast

International Nuclear Information System (INIS)

Kojima, Masayoshi; Kakinuma, Takakiyo

1989-01-01

The interplanetary scintillation (IPS) method using natural radio sources can observe the solar wind near the sun and at high latitudes that have never been accessible to any spacecraft. Therefore, the IPS has been the most powerful method to observe the solar wind in three-dimensional space. Although the IPS method cannot predict when a flare will occur or when a filament will disappear, it can be used to forecast the propagation of interplanetary disturbances and to warn when they will attack the earth. Thus, the IPS method can be used to forecast recurrent interplanetary phenomena as well as transient phenomena. (author)

CONFRONTING THREE-DIMENSIONAL TIME-DEPENDENT JET SIMULATIONS WITH HUBBLE SPACE TELESCOPE OBSERVATIONS

International Nuclear Information System (INIS)

Staff, Jan E.; Niebergal, Brian P.; Ouyed, Rachid; Pudritz, Ralph E.; Cai, Kai

2010-01-01

We perform state-of-the-art, three-dimensional, time-dependent simulations of magnetized disk winds, carried out to simulation scales of 60 AU, in order to confront optical Hubble Space Telescope observations of protostellar jets. We 'observe' the optical forbidden line emission produced by shocks within our simulated jets and compare these with actual observations. Our simulations reproduce the rich structure of time-varying jets, including jet rotation far from the source, an inner (up to 400 km s -1 ) and outer (less than 100 km s -1 ) component of the jet, and jet widths of up to 20 AU in agreement with observed jets. These simulations when compared with the data are able to constrain disk wind models. In particular, models featuring a disk magnetic field with a modest radial spatial variation across the disk are favored.

Lightning Observations from the International Space Station (ISS) for Science Research and Operational Applications

Science.gov (United States)

Blakeslee, R. J.; Christian, H. J.; Mach, D. M.; Buechler, D. E.; Koshak, W. J.; Walker, T. D.; Bateman, M.; Stewart, M. F.; O'Brien, S.; Wilson, T.;

High Fidelity Airborne Imaging System for Remote Observation of Space Launch/Reentry Systems, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — The utility of airborne remote observation of hypersonic reentry vehicles was demonstrated by the NASA Hypersonic Thermodynamic Infrared Measurement (HYTHIRM)...

REPEATABILITY AND ACCURACY OF EXOPLANET ECLIPSE DEPTHS MEASURED WITH POST-CRYOGENIC SPITZER

Energy Technology Data Exchange (ETDEWEB)

Ingalls, James G.; Krick, J. E.; Carey, S. J.; Stauffer, John R.; Lowrance, Patrick J.; Grillmair, Carl J.; Capak, Peter; Glaccum, William; Laine, Seppo; Surace, Jason; Storrie-Lombardi, Lisa [Spitzer Science Center, California Institute of Technology, 1200 E California Boulevard, Mail Code 314-6, Pasadena, CA 91125 (United States); Buzasi, Derek [Department of Chemistry and Physics, Florida Gulf Coast University, Fort Myers, FL 33965 (United States); Deming, Drake [Department of Astronomy, University of Maryland, College Park, MD 20742-2421 (United States); Diamond-Lowe, Hannah; Stevenson, Kevin B. [Department of Astronomy and Astrophysics, University of Chicago, 5640 S Ellis Avenue, Chicago, IL 60637 (United States); Evans, Thomas M. [School of Physics, University of Exeter, EX4 4QL Exeter (United Kingdom); Morello, G. [Department of Physics and Astronomy, University College London, Gower Street, WC1 E6BT (United Kingdom); Wong, Ian, E-mail: ingalls@ipac.caltech.edu [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States)

2016-08-01

We examine the repeatability, reliability, and accuracy of differential exoplanet eclipse depth measurements made using the InfraRed Array Camera (IRAC) on the Spitzer Space Telescope during the post-cryogenic mission. We have re-analyzed an existing 4.5 μ m data set, consisting of 10 observations of the XO-3b system during secondary eclipse, using seven different techniques for removing correlated noise. We find that, on average, for a given technique, the eclipse depth estimate is repeatable from epoch to epoch to within 156 parts per million (ppm). Most techniques derive eclipse depths that do not vary by more than a factor 3 of the photon noise limit. All methods but one accurately assess their own errors: for these methods, the individual measurement uncertainties are comparable to the scatter in eclipse depths over the 10 epoch sample. To assess the accuracy of the techniques as well as to clarify the difference between instrumental and other sources of measurement error, we have also analyzed a simulated data set of 10 visits to XO-3b, for which the eclipse depth is known. We find that three of the methods (BLISS mapping, Pixel Level Decorrelation, and Independent Component Analysis) obtain results that are within three times the photon limit of the true eclipse depth. When averaged over the 10 epoch ensemble,  5 out of 7 techniques come within 60 ppm of the true value. Spitzer exoplanet data, if obtained following current best practices and reduced using methods such as those described here, can measure repeatable and accurate single eclipse depths, with close to photon-limited results.

Two tandemly repeated telomere-associated sequences in Nicotiana plumbaginifolia.

Science.gov (United States)

Chen, C M; Wang, C T; Wang, C J; Ho, C H; Kao, Y Y; Chen, C C

1997-12-01

Two tandemly repeated telomere-associated sequences, NP3R and NP4R, have been isolated from Nicotiana plumbaginifolia. The length of a repeating unit for NP3R and NP4R is 165 and 180 nucleotides respectively. The abundance of NP3R, NP4R and telomeric repeats is, respectively, 8.4 x 10(4), 6 x 10(3) and 1.5 x 10(6) copies per haploid genome of N. plumbaginifolia. Fluorescence in situ hybridization revealed that NP3R is located at the ends and/or in interstitial regions of all 10 chromosomes and NP4R on the terminal regions of three chromosomes in the haploid genome of N. plumbaginifolia. Sequence homology search revealed that not only are NP3R and NP4R homologous to HRS60 and GRS, respectively, two tandem repeats isolated from N. tabacum, but that NP3R and NP4R are also related to each other, suggesting that they originated from a common ancestral sequence. The role of these repeated sequences in chromosome healing is discussed based on the observation that two to three copies of a telomere-similar sequence were present in each repeating unit of NP3R and NP4R.

Hubble Space Telescope Observations of cD Galaxies and Their Globular Cluster Systems

Science.gov (United States)

Jordán, Andrés; Côté, Patrick; West, Michael J.; Marzke, Ronald O.; Minniti, Dante; Rejkuba, Marina

2004-01-01

We have used WFPC2 on the Hubble Space Telescope (HST) to obtain F450W and F814W images of four cD galaxies (NGC 541 in Abell 194, NGC 2832 in Abell 779, NGC 4839 in Abell 1656, and NGC 7768 in Abell 2666) in the range 5400 km s-1cluster (GC) systems reveals no anomalies in terms of specific frequencies, metallicity gradients, average metallicities, or the metallicity offset between the globular clusters and the host galaxy. We show that the latter offset appears roughly constant at Δ[Fe/H]~0.8 dex for early-type galaxies spanning a luminosity range of roughly 4 orders of magnitude. We combine the globular cluster metallicity distributions with an empirical technique described in a series of earlier papers to investigate the form of the protogalactic mass spectrum in these cD galaxies. We find that the observed GC metallicity distributions are consistent with those expected if cD galaxies form through the cannibalism of numerous galaxies and protogalactic fragments that formed their stars and globular clusters before capture and disruption. However, the properties of their GC systems suggest that dynamical friction is not the primary mechanism by which these galaxies are assembled. We argue that cD's instead form rapidly, via hierarchical merging, prior to cluster virialization. Based on observations with the NASA/ESA Hubble Space Telescope obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555 Based in part on observations obtained at the European Southern Observatory, for VLT program 68.D-0130(A).

Operation of a Data Acquisition, Transfer, and Storage System for the Global Space-Weather Observation Network

Directory of Open Access Journals (Sweden)

T Nagatsuma

2014-10-01

Full Text Available A system to optimize the management of global space-weather observation networks has been developed by the National Institute of Information and Communications Technology (NICT. Named the WONM (Wide-area Observation Network Monitoring system, it enables data acquisition, transfer, and storage through connection to the NICT Science Cloud, and has been supplied to observatories for supporting space-weather forecast and research. This system provides us with easier management of data collection than our previously employed systems by means of autonomous system recovery, periodical state monitoring, and dynamic warning procedures. Operation of the WONM system is introduced in this report.

A Unified Model for Repeating and Non-repeating Fast Radio Bursts

International Nuclear Information System (INIS)

Bagchi, Manjari

2017-01-01

The model that fast radio bursts (FRBs) are caused by plunges of asteroids onto neutron stars can explain both repeating and non-repeating bursts. If a neutron star passes through an asteroid belt around another star, there would be a series of bursts caused by a series of asteroid impacts. Moreover, the neutron star would cross the same belt repetitively if it were in a binary with the star hosting the asteroid belt, leading to a repeated series of bursts. I explore the properties of neutron star binaries that could lead to the only known repeating FRB so far (FRB121102). In this model, the next two epochs of bursts are expected around 2017 February 27 and 2017 December 18. On the other hand, if the asteroid belt is located around the neutron star itself, then a chance fall of an asteroid from that belt onto the neutron star would lead to a non-repeating burst. Even a neutron star grazing an asteroid belt can lead to a non-repeating burst caused by just one asteroid plunge during the grazing. This is possible even when the neutron star is in a binary with the asteroid-hosting star, if the belt and the neutron star orbit are non-coplanar.

A Unified Model for Repeating and Non-repeating Fast Radio Bursts

Energy Technology Data Exchange (ETDEWEB)

Bagchi, Manjari, E-mail: manjari@imsc.res.in [The Institute of Mathematical Sciences (IMSc-HBNI), 4th Cross Road, CIT Campus, Taramani, Chennai 600113 (India)

2017-04-01

The model that fast radio bursts (FRBs) are caused by plunges of asteroids onto neutron stars can explain both repeating and non-repeating bursts. If a neutron star passes through an asteroid belt around another star, there would be a series of bursts caused by a series of asteroid impacts. Moreover, the neutron star would cross the same belt repetitively if it were in a binary with the star hosting the asteroid belt, leading to a repeated series of bursts. I explore the properties of neutron star binaries that could lead to the only known repeating FRB so far (FRB121102). In this model, the next two epochs of bursts are expected around 2017 February 27 and 2017 December 18. On the other hand, if the asteroid belt is located around the neutron star itself, then a chance fall of an asteroid from that belt onto the neutron star would lead to a non-repeating burst. Even a neutron star grazing an asteroid belt can lead to a non-repeating burst caused by just one asteroid plunge during the grazing. This is possible even when the neutron star is in a binary with the asteroid-hosting star, if the belt and the neutron star orbit are non-coplanar.

Repeatability of Cryogenic Multilayer Insulation

Science.gov (United States)

Johnson, W. L.; Vanderlaan, M.; Wood, J. J.; Rhys, N. O.; Guo, W.; Van Sciver, S.; Chato, D. J.

2017-12-01

Due to the variety of requirements across aerospace platforms, and one off projects, the repeatability of cryogenic multilayer insulation (MLI) has never been fully established. The objective of this test program is to provide a more basic understanding of the thermal performance repeatability of MLI systems that are applicable to large scale tanks. There are several different types of repeatability that can be accounted for: these include repeatability between identical blankets, repeatability of installation of the same blanket, and repeatability of a test apparatus. The focus of the work in this report is on the first two types of repeatability. Statistically, repeatability can mean many different things. In simplest form, it refers to the range of performance that a population exhibits and the average of the population. However, as more and more identical components are made (i.e. the population of concern grows), the simple range morphs into a standard deviation from an average performance. Initial repeatability testing on MLI blankets has been completed at Florida State University. Repeatability of five Glenn Research Center (GRC) provided coupons with 25 layers was shown to be +/- 8.4% whereas repeatability of repeatedly installing a single coupon was shown to be +/- 8.0%. A second group of 10 coupons has been fabricated by Yetispace and tested by Florida State University, the repeatability between coupons has been shown to be +/- 15-25%. Based on detailed statistical analysis, the data has been shown to be statistically significant.

Prospects for Observing Ultracompact Binaries with Space-Based Gravitational Wave Interferometers and Optical Telescopes

Science.gov (United States)

Littenberg, T. B.; Larson, S. L.; Nelemans, G.; Cornish, N. J.

2012-01-01

Space-based gravitational wave interferometers are sensitive to the galactic population of ultracompact binaries. An important subset of the ultracompact binary population are those stars that can be individually resolved by both gravitational wave interferometers and electromagnetic telescopes. The aim of this paper is to quantify the multimessenger potential of space-based interferometers with arm-lengths between 1 and 5 Gm. The Fisher information matrix is used to estimate the number of binaries from a model of the Milky Way which are localized on the sky by the gravitational wave detector to within 1 and 10 deg(exp 2) and bright enough to be detected by a magnitude-limited survey.We find, depending on the choice ofGW detector characteristics, limiting magnitude and observing strategy, that up to several hundred gravitational wave sources could be detected in electromagnetic follow-up observations.

Relationship between income and repeat criminal victimization in Brazil

Directory of Open Access Journals (Sweden)

Marcelo Justus

2015-09-01

Full Text Available This study analyzes the effect of income on repeat criminal victimization in Brazil using data from the 2009 National Household Sample Survey and its special supplement on victimization and access to justice. Two count-data models were estimated for four types of crime: theft, robbery, attempted theft/robbery, and physical assault. A positive nonlinear effect of income on repeat victimization for the three types of property crimes and a negative nonlinear effect of income on physical assault were observed.

A General Model for Repeated Audit Controls Using Monotone Subsampling

OpenAIRE

Raats, V.M.; van der Genugten, B.B.; Moors, J.J.A.

2002-01-01

In categorical repeated audit controls, fallible auditors classify sample elements in order to estimate the population fraction of elements in certain categories.To take possible misclassifications into account, subsequent checks are performed with a decreasing number of observations.In this paper a model is presented for a general repeated audit control system, where k subsequent auditors classify elements into r categories.Two different sub-sampling procedures will be discussed, named 'stra...

Improvements in anatomy knowledge when utilizing a novel cyclical "Observe-Reflect-Draw-Edit-Repeat" learning process.

Science.gov (United States)

Backhouse, Mark; Fitzpatrick, Michael; Hutchinson, Joseph; Thandi, Charankumal S; Keenan, Iain D

2017-01-01

Innovative educational strategies can provide variety and enhance student learning while addressing complex logistical and financial issues facing modern anatomy education. Observe-Reflect-Draw-Edit-Repeat (ORDER), a novel cyclical artistic process, has been designed based on cognitivist and constructivist learning theories, and on processes of critical observation, reflection and drawing in anatomy learning. ORDER was initially investigated in the context of a compulsory first year surface anatomy practical (ORDER-SAP) at a United Kingdom medical school in which a cross-over trial with pre-post anatomy knowledge testing was utilized and student perceptions were identified. Despite positive perceptions of ORDER-SAP, medical student (n = 154) pre-post knowledge test scores were significantly greater (P learning methods (3.26, SD = ±2.25) than with ORDER-SAP (2.17, ±2.30). Based on these findings, ORDER was modified and evaluated in the context of an optional self-directed gross anatomy online interactive tutorial (ORDER-IT) for participating first year medical students (n = 55). Student performance was significantly greater (P  0.05) to those students without these characteristics. These findings will be of value to anatomy instructors seeking to engage students from diverse learning backgrounds in a research-led, innovative, time and cost-effective learning method, in the context of contrasting learning environments. Anat Sci Educ 10: 7-22. © 2016 American Association of Anatomists. © 2016 American Association of Anatomists.

Multineuronal Spike Sequences Repeat with Millisecond Precision

Directory of Open Access Journals (Sweden)

Koki eMatsumoto

2013-06-01

Full Text Available Cortical microcircuits are nonrandomly wired by neurons. As a natural consequence, spikes emitted by microcircuits are also nonrandomly patterned in time and space. One of the prominent spike organizations is a repetition of fixed patterns of spike series across multiple neurons. However, several questions remain unsolved, including how precisely spike sequences repeat, how the sequences are spatially organized, how many neurons participate in sequences, and how different sequences are functionally linked. To address these questions, we monitored spontaneous spikes of hippocampal CA3 neurons ex vivo using a high-speed functional multineuron calcium imaging technique that allowed us to monitor spikes with millisecond resolution and to record the location of spiking and nonspiking neurons. Multineuronal spike sequences were overrepresented in spontaneous activity compared to the statistical chance level. Approximately 75% of neurons participated in at least one sequence during our observation period. The participants were sparsely dispersed and did not show specific spatial organization. The number of sequences relative to the chance level decreased when larger time frames were used to detect sequences. Thus, sequences were precise at the millisecond level. Sequences often shared common spikes with other sequences; parts of sequences were subsequently relayed by following sequences, generating complex chains of multiple sequences.

Fixed-flexion knee radiography using a new positioning device produced highly repeatable measurements of joint space width: ELSA-Brasil Musculoskeletal Study (ELSA-Brasil MSK).

Science.gov (United States)

Telles, Rosa Weiss; Costa-Silva, Luciana; Machado, Luciana A C; Reis, Rodrigo Citton Padilha Dos; Barreto, Sandhi Maria

To describe the performance of a non-fluoroscopic fixed-flexion PA radiographic protocol with a new positioning device, developed for the assessment of knee osteoarthritis (OA) in Brazilian Longitudinal Study of Adult Health Musculoskeletal Study (ELSA-Brasil MSK). A test-retest design including 19 adults (38 knee images) was conducted. Feasibility of the radiographic protocol was assessed by image quality parameters and presence of radioanatomic alignment according to intermargin distance (IMD) values. Repeatability was assessed for IMD and joint space width (JSW) measured at three different locations. Approximately 90% of knee images presented excellent quality. Frequencies of nearly perfect radioanatomic alignment (IMD ≤1mm) ranged from 29% to 50%, and satisfactory alignment was found in up to 71% and 76% of the images (IMD ≤1.5mm and ≤1.7mm, respectively). Repeatability analyses yielded the following results: IMD [SD of mean difference=1.08; coefficient of variation (%CV)=54.68%; intraclass correlation coefficient (ICC) (95%CI)=0.59 (0.34-0.77)]; JSW [SD of mean difference=0.34-0.61; %CV=4.48%-9.80%; ICC (95%CI)=0.74 (0.55-0.85)-0.94 (0.87-0.97)]. Adequately reproducible measurements of IMD and JSW were found in 68% and 87% of the images, respectively. Despite the difficulty in achieving consistent radioanatomic alignment between subsequent radiographs in terms of IMD, the protocol produced highly repeatable JSW measurements when these were taken at midpoint and 10mm from the medial extremity of the medial tibial plateau. Therefore, measurements of JSW at these locations can be considered adequate for the assessment of knee OA in ELSA-Brasil MSK. Copyright © 2016. Published by Elsevier Editora Ltda.

Fixed-flexion knee radiography using a new positioning device produced highly repeatable measurements of joint space width: ELSA-Brasil Musculoskeletal Study (ELSA-Brasil MSK

Directory of Open Access Journals (Sweden)

Rosa Weiss Telles

Full Text Available Abstract Objective: To describe the performance of a non-fluoroscopic fixed-flexion PA radiographic protocol with a new positioning device, developed for the assessment of knee osteoarthritis (OA in Brazilian Longitudinal Study of Adult Health Musculoskeletal Study (ELSA-Brasil MSK. Material and methods: A test–retest design including 19 adults (38 knee images was conducted. Feasibility of the radiographic protocol was assessed by image quality parameters and presence of radioanatomic alignment according to intermargin distance (IMD values. Repeatability was assessed for IMD and joint space width (JSW measured at three different locations. Results: Approximately 90% of knee images presented excellent quality. Frequencies of nearly perfect radioanatomic alignment (IMD ≤1 mm ranged from 29% to 50%, and satisfactory alignment was found in up to 71% and 76% of the images (IMD ≤1.5 mm and ≤1.7 mm, respectively. Repeatability analyses yielded the following results: IMD [SD of mean difference = 1.08; coefficient of variation (%CV = 54.68%; intraclass correlation coefficient (ICC (95%CI = 0.59 (0.34–0.77]; JSW [SD of mean difference = 0.34–0.61; %CV = 4.48%–9.80%; ICC (95%CI = 0.74 (0.55–0.85–0.94 (0.87–0.97]. Adequately reproducible measurements of IMD and JSW were found in 68% and 87% of the images, respectively. Conclusions: Despite the difficulty in achieving consistent radioanatomic alignment between subsequent radiographs in terms of IMD, the protocol produced highly repeatable JSW measurements when these were taken at midpoint and 10 mm from the medial extremity of the medial tibial plateau. Therefore, measurements of JSW at these locations can be considered adequate for the assessment of knee OA in ELSA-Brasil MSK.

Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington's Disease Knock-In Mice.

Science.gov (United States)

Neto, João Luís; Lee, Jong-Min; Afridi, Ali; Gillis, Tammy; Guide, Jolene R; Dempsey, Stephani; Lager, Brenda; Alonso, Isabel; Wheeler, Vanessa C; Pinto, Ricardo Mouro

2017-02-01

Huntington's disease (HD) is a neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in exon 1 of the HTT gene. Longer repeat sizes are associated with increased disease penetrance and earlier ages of onset. Intergenerationally unstable transmissions are common in HD families, partly underlying the genetic anticipation seen in this disorder. HD CAG knock-in mouse models also exhibit a propensity for intergenerational repeat size changes. In this work, we examine intergenerational instability of the CAG repeat in over 20,000 transmissions in the largest HD knock-in mouse model breeding datasets reported to date. We confirmed previous observations that parental sex drives the relative ratio of expansions and contractions. The large datasets further allowed us to distinguish effects of paternal CAG repeat length on the magnitude and frequency of expansions and contractions, as well as the identification of large repeat size jumps in the knock-in models. Distinct degrees of intergenerational instability were observed between knock-in mice of six background strains, indicating the occurrence of trans-acting genetic modifiers. We also found that lines harboring a neomycin resistance cassette upstream of Htt showed reduced expansion frequency, indicative of a contributing role for sequences in cis, with the expanded repeat as modifiers of intergenerational instability. These results provide a basis for further understanding of the mechanisms underlying intergenerational repeat instability. Copyright © 2017 by the Genetics Society of America.

Comparison of serum leptin, glucose, total cholesterol and total protein levels in fertile and repeat breeder cows

Directory of Open Access Journals (Sweden)

Saime Guzel

2014-12-01

Full Text Available In the present study we measured serum glucose, leptin, total cholesterol and total protein concentrations in repeat breeder cows and compared them with fertile cows. For this aim, 20 repeat breeder cows and 20 fertile cows were used as material. Repeat breeder cows were found to have lower levels of leptin and glucose as compared with fertile ones. No significant differences in total cholesterol and total protein levels were observed between the two groups. No significant correlation of leptin with glucose, total cholesterol and total protein was observed in fertile and repeat breeder cows. Low concentrations of glucose and leptin can have some effects on reproductive problems as repeat breeder and help to understand potential mechanisms impairing fertility in repeat breeder cows.

Deployment Repeatability

Science.gov (United States)

2016-04-01

evaluating the deployment repeatability builds upon the testing or analysis of deployment kinematics (Chapter 6) and adds repetition. Introduction...material yield or failure during a test. For the purposes of this chapter, zero shift will refer to permanent changes in the structure, while reversible ...the content of other chapters in this book: Gravity Compensation (Chapter 4) and Deployment Kinematics and Dynamics (Chapter 6). Repeating the

Effect of repeated freezing-thawing on the Achilles tendon of rabbits.

Science.gov (United States)

Chen, Lianxu; Wu, Yanping; Yu, Jiakuo; Jiao, Zhaode; Ao, Yingfang; Yu, Changlong; Wang, Jianquan; Cui, Guoqing

2011-06-01

The increased use of allograft tissue in the reconstruction of anterior cruciate ligament has brought more focus to the effect of storage and treatment on allograft. The purpose of this study was to observe the effect of histology and biomechanics on Achilles tendon in rabbits through repeated freezing-thawing before allograft tendon transplantation. Rabbit Achilles tendons were harvested and processed according to the manufacture's protocol of tissue bank, and freezing-thawing was repeated three times (group 1) and ten times (group 2). Those received only one cycle were used as controls. Then, tendons in each group were selected randomly to make for histological observations and biomechanics test. Histological observation showed that the following changes happened as the number of freezing-thawing increased: the arrangement of tendon bundles and collagen fibrils became disordered until ruptured, cells disrupted and apparent gaps appeared between tendon bundle because the formation of ice crystals. There were significant differences between the experimental and control groups in the values of maximum load, energy of maximum load and maximum stress, whereas no significant differences existed in other values such as stiffness, maximum strain, elastic modulus, and energy density. Therefore, repeated freezing-thawing had histological and biomechanical effect on Achilles tendon in rabbits before allograft tendon transplantation. This indicates that cautions should be taken in the repeated freezing-thawing preparation of allograft tendons in clinical application.

Reconfigurable multiport EPON repeater

Science.gov (United States)

Oishi, Masayuki; Inohara, Ryo; Agata, Akira; Horiuchi, Yukio

2009-11-01

An extended reach EPON repeater is one of the solutions to effectively expand FTTH service areas. In this paper, we propose a reconfigurable multi-port EPON repeater for effective accommodation of multiple ODNs with a single OLT line card. The proposed repeater, which has multi-ports in both OLT and ODN sides, consists of TRs, BTRs with the CDR function and a reconfigurable electrical matrix switch, can accommodate multiple ODNs to a single OLT line card by controlling the connection of the matrix switch. Although conventional EPON repeaters require full OLT line cards to accommodate subscribers from the initial installation stage, the proposed repeater can dramatically reduce the number of required line cards especially when the number of subscribers is less than a half of the maximum registerable users per OLT. Numerical calculation results show that the extended reach EPON system with the proposed EPON repeater can save 17.5% of the initial installation cost compared with a conventional repeater, and can be less expensive than conventional systems up to the maximum subscribers especially when the percentage of ODNs in lightly-populated areas is higher.

Online learning in repeated auctions

OpenAIRE

Weed, Jonathan; Perchet, Vianney; Rigollet, Philippe

2015-01-01

Motivated by online advertising auctions, we consider repeated Vickrey auctions where goods of unknown value are sold sequentially and bidders only learn (potentially noisy) information about a good's value once it is purchased. We adopt an online learning approach with bandit feedback to model this problem and derive bidding strategies for two models: stochastic and adversarial. In the stochastic model, the observed values of the goods are random variables centered around the true value of t...

On-Chip Quantum Repeater in Diamond for Space-Based Quantum Communication

Data.gov (United States)

National Aeronautics and Space Administration — The focus of my research is on the optical properties of diamond. A diamond is composed of a crystal arrangement of carbon atoms and it is this structure that gives...

High Temporal Resolution Tropospheric Wind Profile Observations at NASA Kennedy Space Center During Hurricane Irma

Science.gov (United States)

Decker, Ryan K.; Barbre, Robert E., Jr.; Huddleston, Lisa; Brauer, Thomas; Wilfong, Timothy

2018-01-01

The NASA Kennedy Space Center (KSC) operates a 48-MHz Tropospheric/Stratospheric Doppler Radar Wind Profiler (TDRWP) on a continual basis generating wind profiles between 2-19 km in the support of space launch vehicle operations. A benefit of the continual operability of the system is the ability to provide unique observations of severe weather events such as hurricanes. Over the past two Atlantic Hurricane seasons the TDRWP has made high temporal resolution wind profile observations of Hurricane Irma in 2017 and Hurricane Matthew in 2016. Hurricane Irma was responsible for power outages to approximately 2/3 of Florida's population during its movement over the state(Stein,2017). An overview of the TDRWP system configuration, brief summary of Hurricanes Irma and Matthew storm track in proximity to KSC, characteristics of the tropospheric wind observations from the TDRWP during both events, and discussion of the dissemination of TDRWP data during the event will be presented.

Earth rotation excitation mechanisms derived from geodetic space observations

Science.gov (United States)

Göttl, F.; Schmidt, M.

2009-04-01

Earth rotation variations are caused by mass displacements and motions in the subsystems of the Earth. Via the satellite Gravity and Climate Experiment (GRACE) gravity field variations can be identified which are caused by mass redistribution in the Earth system. Therefore time variable gravity field models (GFZ RL04, CSR RL04, JPL RL04, ITG-Grace03, GRGS, ...) can be used to derive different impacts on Earth rotation. Furthermore satellite altimetry provides accurate information on sea level anomalies (AVISO, DGFI) which are caused by mass and volume changes of seawater. Since Earth rotation is solely affected by mass variations and motions the volume (steric) effect has to be reduced from the altimetric observations in order to infer oceanic contributions to Earth rotation variations. Therefore the steric effect is estimated from physical ocean parameters such as temperature and salinity changes in the oceans (WOA05, Ishii). In this study specific individual geophysical contributions to Earth rotation variations are identified by means of a multitude of accurate geodetic space observations in combination with a realistic error propagation. It will be shown that due to adjustment of altimetric and/or gravimetric solutions the results for polar motion excitations can be improved.

Understanding the Longitudinal Variability of Equatorial Electrodynamics using integrated Ground- and Space-based Observations

Science.gov (United States)

Yizengaw, E.; Moldwin, M.; Zesta, E.

2015-12-01

The currently funded African Meridian B-Field Education and Research (AMBER) magnetometer array comprises more than thirteen magnetometers stationed globally in the vicinity of geomagnetic equator. One of the main objectives of AMBER network is to understand the longitudinal variability of equatorial electrodynamics as function of local time, magnetic activity, and season. While providing complete meridian observation in the region and filling the largest land-based gap in global magnetometer coverage, the AMBER array addresses two fundamental areas of space physics: first, the processes governing electrodynamics of the equatorial ionosphere as a function of latitude (or L-shell), local time, longitude, magnetic activity, and season, and second, ULF pulsation strength at low/mid-latitude regions and its connection with equatorial electrojet and density fluctuation. The global AMBER network can also be used to augment observations from space-based instruments, such us the triplet SWARM mission and the upcoming ICON missions. Thus, in coordination with space-based and other ground-based observations, the AMBER magnetometer network provides a great opportunity to understand the electrodynamics that governs equatorial ionosphere motions. In this paper we present the longitudinal variability of the equatorial electrodynamics using the combination of instruments onboard SWARM and C/NOFS satellites and ground-based AMBER network. Both ground- and pace-based observations show stronger dayside and evening sector equatorial electrodynamics in the American and Asian sectors compared to the African sector. On the other hand, the African sector is home to stronger and year-round ionospheric bubbles/irregularities compared to the American and Asian sectors. This raises the question if the evening sector equatorial electrodynamics (vertical drift), which is believed to be the main cause for the enhancement of Rayleigh-Taylor (RT) instability growth rate, is stronger in the

High Precision Optical Observations of Space Debris in the Geo Ring from Venezuela

Science.gov (United States)

Lacruz, E.; Abad, C.; Downes, J. J.; Casanova, D.; Tresaco, E.

2018-01-01

We present preliminary results to demonstrate that our method for detection and location of Space Debris (SD) in the geostationary Earth orbit (GEO) ring, based on observations at the OAN of Venezuela is of high astrometric precision. A detailed explanation of the method, its validation and first results is available in (Lacruz et al. 2017).

Constraining Parameters in Pulsar Models of Repeating FRB 121102 with High-energy Follow-up Observations

Energy Technology Data Exchange (ETDEWEB)

Xiao, Di; Dai, Zi-Gao, E-mail: dzg@nju.edu.cn [School of Astronomy and Space Science, Nanjing University, Nanjing 210093 (China)

2017-09-10

Recently, a precise (sub-arcsecond) localization of the repeating fast radio burst (FRB) 121102 led to the discovery of persistent radio and optical counterparts, the identification of a host dwarf galaxy at a redshift of z = 0.193, and several campaigns of searches for higher-frequency counterparts, which gave only upper limits on the emission flux. Although the origin of FRBs remains unknown, most of the existing theoretical models are associated with pulsars, or more specifically, magnetars. In this paper, we explore persistent high-energy emission from a rapidly rotating highly magnetized pulsar associated with FRB 121102 if internal gradual magnetic dissipation occurs in the pulsar wind. We find that the efficiency of converting the spin-down luminosity to the high-energy (e.g., X-ray) luminosity is generally much smaller than unity, even for a millisecond magnetar. This provides an explanation for the non-detection of high-energy counterparts to FRB 121102. We further constrain the spin period and surface magnetic field strength of the pulsar with the current high-energy observations. In addition, we compare our results with the constraints given by the other methods in previous works and expect to apply our new method to some other open issues in the future.

Constraining Parameters in Pulsar Models of Repeating FRB 121102 with High-energy Follow-up Observations

International Nuclear Information System (INIS)

Xiao, Di; Dai, Zi-Gao

2017-01-01

Recently, a precise (sub-arcsecond) localization of the repeating fast radio burst (FRB) 121102 led to the discovery of persistent radio and optical counterparts, the identification of a host dwarf galaxy at a redshift of z = 0.193, and several campaigns of searches for higher-frequency counterparts, which gave only upper limits on the emission flux. Although the origin of FRBs remains unknown, most of the existing theoretical models are associated with pulsars, or more specifically, magnetars. In this paper, we explore persistent high-energy emission from a rapidly rotating highly magnetized pulsar associated with FRB 121102 if internal gradual magnetic dissipation occurs in the pulsar wind. We find that the efficiency of converting the spin-down luminosity to the high-energy (e.g., X-ray) luminosity is generally much smaller than unity, even for a millisecond magnetar. This provides an explanation for the non-detection of high-energy counterparts to FRB 121102. We further constrain the spin period and surface magnetic field strength of the pulsar with the current high-energy observations. In addition, we compare our results with the constraints given by the other methods in previous works and expect to apply our new method to some other open issues in the future.

High resolution solar observations in the context of space weather prediction

Science.gov (United States)

Yang, Guo

Space weather has a great impact on the Earth and human life. It is important to study and monitor active regions on the solar surface and ultimately to predict space weather based on the Sun's activity. In this study, a system that uses the full power of speckle masking imaging by parallel processing to obtain high-spatial resolution images of the solar surface in near real-time has been developed and built. The application of this system greatly improves the ability to monitor the evolution of solar active regions and to predict the adverse effects of space weather. The data obtained by this system have also been used to study fine structures on the solar surface and their effects on the upper solar atmosphere. A solar active region has been studied using high resolution data obtained by speckle masking imaging. Evolution of a pore in an active region presented. Formation of a rudimentary penumbra is studied. The effects of the change of the magnetic fields on the upper level atmosphere is discussed. Coronal Mass Ejections (CMEs) have a great impact on space weather. To study the relationship between CMEs and filament disappearance, a list of 431 filament and prominence disappearance events has been compiled. Comparison of this list with CME data obtained by satellite has shown that most filament disappearances seem to have no corresponding CME events. Even for the limb events, only thirty percent of filament disappearances are associated with CMEs. A CME event that was observed on March 20, 2000 has been studied in detail. This event did not show the three-parts structure of typical CMEs. The kinematical and morphological properties of this event were examined.

Expression, crystallization and preliminary crystallographic data analysis of filamin A repeats 14–16

International Nuclear Information System (INIS)

Aguda, Adeleke Halilu; Sakwe, Amos Malle; Rask, Lars; Robinson, Robert Charles

2007-01-01

The crystallization and crystallographic data analysis of filamin repeats 14–16 are reported. Human filamin A is a 280 kDa protein involved in actin-filament cross-linking. It is structurally divided into an actin-binding headpiece (ABD) and a rod domain containing 24 immunoglobulin-like (Ig) repeats. A fragment of human filamin A (Ig repeats 14–16) was cloned and expressed in Escherichia coli and the purified protein was crystallized in 1.6 M ammonium sulfate, 2% PEG 1000 and 100 mM HEPES pH 7.5. The crystals diffracted to 1.95 Å and belong to space group P2 1 2 1 2 1 , with unit-cell parameters a = 50.63, b = 52.10, c = 98.46 Å, α = β = γ = 90°

Dynamic auroral storms on Saturn as observed by the Hubble Space Telescope.

Science.gov (United States)

Nichols, J D; Badman, S V; Baines, K H; Brown, R H; Bunce, E J; Clarke, J T; Cowley, S W H; Crary, F J; Dougherty, M K; Gérard, J-C; Grocott, A; Grodent, D; Kurth, W S; Melin, H; Mitchell, D G; Pryor, W R; Stallard, T S

2014-05-28

We present observations of significant dynamics within two UV auroral storms observed on Saturn using the Hubble Space Telescope in April/May 2013. Specifically, we discuss bursts of auroral emission observed at the poleward boundary of a solar wind-induced auroral storm, propagating at ∼330% rigid corotation from near ∼01 h LT toward ∼08 h LT. We suggest that these are indicative of ongoing, bursty reconnection of lobe flux in the magnetotail, providing strong evidence that Saturn's auroral storms are caused by large-scale flux closure. We also discuss the later evolution of a similar storm and show that the emission maps to the trailing region of an energetic neutral atom enhancement. We thus identify the auroral form with the upward field-aligned continuity currents flowing into the associated partial ring current.

Spatial and temporal repeatability in parasite community structure of tropical fish hosts.

Science.gov (United States)

Vidal-Martínez, V M; Poulin, R

2003-10-01

An assessment is made of the repeatability of parasite community structure in space for a marine fish, and in space and time for a freshwater fish from south-eastern Mexico. The marine fish species was the red grouper, Epinephelus morio (collected from 9 localities), and the freshwater species was the cichlid, Cichlasoma urophthalmus (collected from 6 localities: including monthly at 2 localities for 1 year, and bimonthly at 1 locality in 1990 and 1999). Pairwise interspecific associations and analyses of nested patterns in the distributions of parasite species among hosts were used in both fish species, with comparisons over time made only with the cichlid. Positive interspecific associations, and nested patterns were noted in some localities for both fish species, and/or at some sampling times for the cichlid fish. However, non-random patterns in the structure of parasite communities in these 2 host species only were observed sporadically. When present, nestedness in both fish species was apparently linked with a positive association between total infection intensities and fish size. Additionally, adjacent localities were more likely to display similar parasite community structure than distant ones. This preliminary result suggests that distance between localities is an important determinant of predictability in parasite community structure.

Thermal stability of chicken brain {alpha}-spectrin repeat 17: a spectroscopic study

Energy Technology Data Exchange (ETDEWEB)

Brenner, Annette K. [University of Bergen, Department of Chemistry (Norway); Kieffer, Bruno [Ecole Superieure de Biotechnologie de Strasbourg, IGBMC Biomolecular NMR Group, CNRS UMR 7104 (France); Trave, Gilles [Ecole Superieure de Biotechnologie de Strasbourg, Equipe Oncoproteines, IREBS, UMR 7242 (France); Froystein, Nils Age [University of Bergen, Department of Chemistry (Norway); Raae, Arnt J., E-mail: arnt.raae@mbi.uib.no [University of Bergen, Department of Molecular Biology (Norway)

2012-06-15

Spectrin is a rod-like multi-modular protein that is mainly composed of triple-helical repeats. These repeats show very similar 3D-structures but variable conformational and thermodynamical stabilities, which may be of great importance for the flexibility and dynamic behaviour of spectrin in the cell. For instance, repeat 17 (R17) of the chicken brain spectrin {alpha}-chain is four times less stable than neighbouring repeat 16 (R16) in terms of Increment G. The structure of spectrin repeats has mainly been investigated by X-ray crystallography, but the structures of a few repeats, e.g. R16, have also been determined by NMR spectroscopy. Here, we undertook a detailed characterization of the neighbouring R17 by NMR spectroscopy. We assigned most backbone resonances and observed NOE restraints, relaxation values and coupling constants that all indicated that the fold of R17 is highly similar to that of R16, in agreement with previous X-ray analysis of a tandem repeat of the two domains. However, {sup 15}N heteronuclear NMR spectra measured at different temperatures revealed particular features of the R17 domain that might contribute to its lower stability. Conformational exchange appeared to alter the linker connecting R17 to R16 as well as the BC-loop in close proximity. In addition, heat-induced splitting was observed for backbone resonances of a few spatially related residues including V99 of helix C, which in R16 is replaced by the larger hydrophobic tryptophan residue that is relatively conserved among other spectrin repeats. These data support the view that the substitution of tryptophan by valine at this position may contribute to the lower stability of R17.

Determining the orientation of the observed object in threedimensional space using stereo vision methods

International Nuclear Information System (INIS)

Ponomarev, S

2014-01-01

The task of matching image of an object with its template is central for many optoelectronic systems. Solution of the matching problem in three-dimensional space in contrast to the structural alignment in the image plane allows using a larger amount of information about the object for determining its orientation, which may increase the probability of correct matching. In the case of stereo vision methods for constructing a three-dimensional image of the object, it becomes possible to achieve invariance w.r.t. background and distance to the observed object. Only three of the orientation angle of the object relative to the camera are uncertain and require measurements. This paper proposes a method for determining the orientation angles of the observed object in three-dimensional space, which is based on the processing of stereo image sequences. Disparity map segmentation method that allows one to ensure the invariance of the background is presented. Quantitative estimates of the effectiveness of the proposed method are presented and discussed.

Expansion of protein domain repeats.

Directory of Open Access Journals (Sweden)

Asa K Björklund

2006-08-01

Full Text Available Many proteins, especially in eukaryotes, contain tandem repeats of several domains from the same family. These repeats have a variety of binding properties and are involved in protein-protein interactions as well as binding to other ligands such as DNA and RNA. The rapid expansion of protein domain repeats is assumed to have evolved through internal tandem duplications. However, the exact mechanisms behind these tandem duplications are not well-understood. Here, we have studied the evolution, function, protein structure, gene structure, and phylogenetic distribution of domain repeats. For this purpose we have assigned Pfam-A domain families to 24 proteomes with more sensitive domain assignments in the repeat regions. These assignments confirmed previous findings that eukaryotes, and in particular vertebrates, contain a much higher fraction of proteins with repeats compared with prokaryotes. The internal sequence similarity in each protein revealed that the domain repeats are often expanded through duplications of several domains at a time, while the duplication of one domain is less common. Many of the repeats appear to have been duplicated in the middle of the repeat region. This is in strong contrast to the evolution of other proteins that mainly works through additions of single domains at either terminus. Further, we found that some domain families show distinct duplication patterns, e.g., nebulin domains have mainly been expanded with a unit of seven domains at a time, while duplications of other domain families involve varying numbers of domains. Finally, no common mechanism for the expansion of all repeats could be detected. We found that the duplication patterns show no dependence on the size of the domains. Further, repeat expansion in some families can possibly be explained by shuffling of exons. However, exon shuffling could not have created all repeats.

The Latest Space-Borne Observations of TGFs from Fermi-GBM

Science.gov (United States)

Fishman, Gerald J.

2010-01-01

The Gamma-ray Burst Monitor (GBM) on the Fermi Gamma-ray Space Telescope Observatory (Fermi) is detecting about two TGFs per week. This rate has increased by a factor of approx.eight since launch when flight software was uploaded to the spacecraft in November 2009 in order to increase the sensitivity of GBM to TGFs. Weaker, un-triggered TGFs are now also being observed about once per day over selected low-latitude regions Americas. The high efficiency and time resolution (2 s) of GBM allows temporal features to be resolved so that some insight may be gained on the origin and transport of the gamma-ray photons through the atmosphere. TGFs are observed to be shorter than previously thought, with an average duration of approx.100 micro-s. The absolute times of TGFs are known to approx.10 micro-s, allowing accurate correlations of TGFs with lightning networks and other lightning-related phenomena. The events are observed in the thick bismuth germanate (BGO) scintillation detectors of GBM with photon energies above 40 MeV. Other new results on the temporal and spectral characteristics of TGFs will be presented, along with properties of several electron-positron TGF events that have been identified.

HUBBLE SPACE TELESCOPE OBSERVATIONS OF MAIN-BELT COMET (596) SCHEILA

International Nuclear Information System (INIS)

Jewitt, David; Weaver, Harold; Mutchler, Max; Larson, Stephen; Agarwal, Jessica

2011-01-01

We present Hubble Space Telescope Observations of (596) Scheila during its recent dust outburst. The nucleus remained point-like with absolute magnitude H V = 8.85 ± 0.02 in our data, equal to the pre-outburst value, with no secondary fragments of diameter ≥100 m (for assumed albedos 0.04). We find a coma having a peak scattering cross section ∼2.2x10 4 km 2 , corresponding to a mass in micron-sized particles of ∼4x10 7 kg. The particles are deflected by solar radiation pressure on projected spatial scales ∼2x10 4 km, in the sunward direction, and swept from the vicinity of the nucleus on timescales of weeks. The coma fades by ∼30% between observations on UT 2010 December 27 and 2011 January 4. The observed mass loss is inconsistent with an origin either by rotational instability of the nucleus or by electrostatic ejection of regolith charged by sunlight. Dust ejection could be caused by the sudden but unexplained exposure of buried ice. However, the data are most simply explained by the impact, at ∼5 km s -1 , of a previously unknown asteroid ∼35 m in diameter.

The leucine-rich repeat structure.

Science.gov (United States)

Bella, J; Hindle, K L; McEwan, P A; Lovell, S C

2008-08-01

The leucine-rich repeat is a widespread structural motif of 20-30 amino acids with a characteristic repetitive sequence pattern rich in leucines. Leucine-rich repeat domains are built from tandems of two or more repeats and form curved solenoid structures that are particularly suitable for protein-protein interactions. Thousands of protein sequences containing leucine-rich repeats have been identified by automatic annotation methods. Three-dimensional structures of leucine-rich repeat domains determined to date reveal a degree of structural variability that translates into the considerable functional versatility of this protein superfamily. As the essential structural principles become well established, the leucine-rich repeat architecture is emerging as an attractive framework for structural prediction and protein engineering. This review presents an update of the current understanding of leucine-rich repeat structure at the primary, secondary, tertiary and quaternary levels and discusses specific examples from recently determined three-dimensional structures.

Space-time structure

CERN Document Server

Schrödinger, Erwin

1985-01-01

In response to repeated requests this classic book on space-time structure by Professor Erwin Schrödinger is now available in the Cambridge Science Classics series. First published in 1950, and reprinted in 1954 and 1960, this lucid and profound exposition of Einstein's 1915 theory of gravitation still provides valuable reading for students and research workers in the field.

Overcoming fixation with repeated memory suppression.

Science.gov (United States)

Angello, Genna; Storm, Benjamin C; Smith, Steven M

2015-01-01

Fixation (blocks to memories or ideas) can be alleviated not only by encouraging productive work towards a solution, but, as the present experiments show, by reducing counterproductive work. Two experiments examined relief from fixation in a word-fragment completion task. Blockers, orthographically similar negative primes (e.g., ANALOGY), blocked solutions to word fragments (e.g., A_L_ _GY) in both experiments. After priming, but before the fragment completion test, participants repeatedly suppressed half of the blockers using the Think/No-Think paradigm, which results in memory inhibition. Inhibiting blockers did not alleviate fixation in Experiment 1 when conscious recollection of negative primes was not encouraged on the fragment completion test. In Experiment 2, however, when participants were encouraged to remember negative primes at fragment completion, relief from fixation was observed. Repeated suppression may nullify fixation effects, and promote creative thinking, particularly when fixation is caused by conscious recollection of counterproductive information.

Bilateral cross-bite treated by repeated rapid maxillary expansions: a 17-year follow-up case.

Science.gov (United States)

Cozzani, M; Mazzotta, L; Caprioglio, A

2014-07-01

The objective of this paper is to show the clinical results after the repeated application of a Haas expander for rapid maxillary expansion (RME) anchored onto deciduous teeth in a 7-year-old patient that presented bilateral cross-bite, superior crowding and no space for permanent lateral incisors eruption. A first Haas expander was applied to the patient. She was told to activate it once a day, each activation was equal to 0.20 mm. After the first RME, the bilateral cross-bite was solved but still there was not enough space for lateral incisor eruption. A second and then a third Haas expander were applied, with the same activation protocol as the first one, in order to gain space in the anterior region and to achieve proper eruption of the lateral incisors. The patient was then treated with fixed appliances. At debonding the patient presented well aligned arch-forms: space for lateral incisor eruption was gained and superior crowding was solved. Bilateral cross-bite was also corrected. She was seen again 10 years and 17 years after expansions: she showed no relapse and presented a good functional occlusion that had remained stable, and an aesthetically pleasant smile, however she exhibited gingival recessions. Repeated rapid maxillary expansion, anchored onto deciduous teeth, performed in early mixed dentition represents a safe and successful treatment to correct severe bilateral cross- bites and to create space for maxillary incisor eruption.

Hysteresis of magnetostructural transitions: Repeatable and non-repeatable processes

Science.gov (United States)

Provenzano, Virgil; Della Torre, Edward; Bennett, Lawrence H.; ElBidweihy, Hatem

2014-02-01

The Gd5Ge2Si2 alloy and the off-stoichiometric Ni50Mn35In15 Heusler alloy belong to a special class of metallic materials that exhibit first-order magnetostructural transitions near room temperature. The magnetic properties of this class of materials have been extensively studied due to their interesting magnetic behavior and their potential for a number of technological applications such as refrigerants for near-room-temperature magnetic refrigeration. The thermally driven first-order transitions in these materials can be field-induced in the reverse order by applying a strong enough field. The field-induced transitions are typically accompanied by the presence of large magnetic hysteresis, the characteristics of which are a complicated function of temperature, field, and magneto-thermal history. In this study we show that the virgin curve, the major loop, and sequentially measured MH loops are the results of both repeatable and non-repeatable processes, in which the starting magnetostructural state, prior to the cycling of field, plays a major role. Using the Gd5Ge2Si2 and Ni50Mn35In15 alloys, as model materials, we show that a starting single phase state results in fully repeatable processes and large magnetic hysteresis, whereas a mixed phase starting state results in non-repeatable processes and smaller hysteresis.

Hysteresis of magnetostructural transitions: Repeatable and non-repeatable processes

International Nuclear Information System (INIS)

Provenzano, Virgil; Della Torre, Edward; Bennett, Lawrence H.; ElBidweihy, Hatem

2014-01-01

The Gd 5 Ge 2 Si 2 alloy and the off-stoichiometric Ni 50 Mn 35 In 15 Heusler alloy belong to a special class of metallic materials that exhibit first-order magnetostructural transitions near room temperature. The magnetic properties of this class of materials have been extensively studied due to their interesting magnetic behavior and their potential for a number of technological applications such as refrigerants for near-room-temperature magnetic refrigeration. The thermally driven first-order transitions in these materials can be field-induced in the reverse order by applying a strong enough field. The field-induced transitions are typically accompanied by the presence of large magnetic hysteresis, the characteristics of which are a complicated function of temperature, field, and magneto-thermal history. In this study we show that the virgin curve, the major loop, and sequentially measured MH loops are the results of both repeatable and non-repeatable processes, in which the starting magnetostructural state, prior to the cycling of field, plays a major role. Using the Gd 5 Ge 2 Si 2 and Ni 50 Mn 35 In 15 alloys, as model materials, we show that a starting single phase state results in fully repeatable processes and large magnetic hysteresis, whereas a mixed phase starting state results in non-repeatable processes and smaller hysteresis

Revisiting the TALE repeat.

Science.gov (United States)

Deng, Dong; Yan, Chuangye; Wu, Jianping; Pan, Xiaojing; Yan, Nieng

2014-04-01

Transcription activator-like (TAL) effectors specifically bind to double stranded (ds) DNA through a central domain of tandem repeats. Each TAL effector (TALE) repeat comprises 33-35 amino acids and recognizes one specific DNA base through a highly variable residue at a fixed position in the repeat. Structural studies have revealed the molecular basis of DNA recognition by TALE repeats. Examination of the overall structure reveals that the basic building block of TALE protein, namely a helical hairpin, is one-helix shifted from the previously defined TALE motif. Here we wish to suggest a structure-based re-demarcation of the TALE repeat which starts with the residues that bind to the DNA backbone phosphate and concludes with the base-recognition hyper-variable residue. This new numbering system is consistent with the α-solenoid superfamily to which TALE belongs, and reflects the structural integrity of TAL effectors. In addition, it confers integral number of TALE repeats that matches the number of bound DNA bases. We then present fifteen crystal structures of engineered dHax3 variants in complex with target DNA molecules, which elucidate the structural basis for the recognition of bases adenine (A) and guanine (G) by reported or uncharacterized TALE codes. Finally, we analyzed the sequence-structure correlation of the amino acid residues within a TALE repeat. The structural analyses reported here may advance the mechanistic understanding of TALE proteins and facilitate the design of TALEN with improved affinity and specificity.

Multicolor Photometric Observation of Lightning from Space: Comparison with Radio Measurements

Science.gov (United States)

Adachi, Toru; Cohen, Morris; Said, Ryan; Blakeslee, Richard J.; Cummer, Steven A.; Li, Jingbo; Lu, Geopeng; Hsu, Rue-Ron; Su, Han-Tzong; Chen, Alfred Bing-Chih;

Observation of Octupole Driven Resonance Phenomena with Space Charge at the CERN Proton Synchrotron

CERN Document Server

Métral, E; Martini, M; Steerenberg, R; Franchetti, Giuliano; Hofmann, I

2006-01-01

Several benchmarking space charge experiments have been performed during the last few years in the CERN Proton Synchrotron. These controlled experiments are of paramount importance to validate the present very powerful simulation codes. The observations of the combined effect of space charge and nonlinear resonance on beam loss and emittance, using a single controllable octupole during ~ 1 s at 1.4 GeV kinetic energy, are discussed in some detail in the present paper. By lowering the working point towards the octupolar resonance, a gradual transition from a regime of loss-free core emittance blow-up to a regime of continuous loss was found.

All-photonic quantum repeaters

Science.gov (United States)

Azuma, Koji; Tamaki, Kiyoshi; Lo, Hoi-Kwong

2015-01-01

Quantum communication holds promise for unconditionally secure transmission of secret messages and faithful transfer of unknown quantum states. Photons appear to be the medium of choice for quantum communication. Owing to photon losses, robust quantum communication over long lossy channels requires quantum repeaters. It is widely believed that a necessary and highly demanding requirement for quantum repeaters is the existence of matter quantum memories. Here we show that such a requirement is, in fact, unnecessary by introducing the concept of all-photonic quantum repeaters based on flying qubits. In particular, we present a protocol based on photonic cluster-state machine guns and a loss-tolerant measurement equipped with local high-speed active feedforwards. We show that, with such all-photonic quantum repeaters, the communication efficiency scales polynomially with the channel distance. Our result paves a new route towards quantum repeaters with efficient single-photon sources rather than matter quantum memories. PMID:25873153

Automated detection of repeated structures in building facades

Directory of Open Access Journals (Sweden)

M. Previtali

2013-10-01

Full Text Available Automatic identification of high-level repeated structures in 3D point clouds of building façades is crucial for applications like digitalization and building modelling. Indeed, in many architectural styles building façades are governed by arrangements of objects into repeated patterns. In particular, façades are generally designed as the repetition of some few basic objects organized into interlaced and\\or concatenated grid structures. Starting from this key observation, this paper presents an algorithm for Repeated Structure Detection (RSD in 3D point clouds of building façades. The presented methodology consists of three main phases. First, in the point cloud segmentation stage (i the building façade is decomposed into planar patches which are classified by means of some weak prior knowledge of urban buildings formulated in a classification tree. Secondly (ii, in the element clustering phase detected patches are grouped together by means of a similarity function and pairwise transformations between patches are computed. Eventually (iii, in the structure regularity estimation step the parameters of repeated grid patterns are calculated by using a Least- Squares optimization. Workability of the presented approach is tested using some real data from urban scenes.

Use of Virtual Reality for Space Flight

Science.gov (United States)

Harm, Deborah; Taylor, L. C.; Reschke, M. F.

2011-01-01

Virtual environments offer unique training opportunities, particularly for training astronauts and preadapting them to the novel sensory conditions of microgravity. Two unresolved human factors issues in virtual reality (VR) systems are: 1) potential "cybersickness", and 2) maladaptive sensorimotor performance following exposure to VR systems. Interestingly, these aftereffects are often quite similar to adaptive sensorimotor responses observed in astronauts during and/or following space flight. Active exploratory behavior in a new environment, with resulting feedback and the formation of new associations between sensory inputs and response outputs, promotes appropriate perception and motor control in the new environment. Thus, people adapt to consistent, sustained alterations of sensory input such as those produced by microgravity. Our research examining the effects of repeated exposures to a full field of view dome VR system showed that motion sickness and initial decrements in eye movement and postural control were greatly diminished following three exposures. These results suggest that repeated transitions between VR and the normal environment preflight might be a useful countermeasure for neurosensory and sensorimotor effects of space flight. The range of VR applications is enormous, extending from ground-based VR training for extravehicular activities at NASA, to medical and educational uses. It seems reasonable to suggest that other space related uses of VR should be investigated. For example, 1) use of head-mounted VR on orbit to rehearse/practice upcoming operational activities, and 2) ground-based VR training for emergency egress procedures. We propose that by combining VR designed for operational activities preflight, along with an appropriate schedule to facilitate sensorimotor adaptation and improve spatial orientation would potentially accomplish two important goals for astronauts and cosmonauts, preflight sensorimotor adaption and enhanced operational

Space Weather at Mars: MAVEN and MSL/RAD Observations of CME and SEP Events

Science.gov (United States)

Lee, C. O.; Ehresmann, B.; Lillis, R. J.; Dunn, P.; Rahmati, A.; Larson, D. E.; Guo, J.; Zeitlin, C.; Luhmann, J. G.; Halekas, J. S.; Espley, J. R.; Thiemann, E.; Hassler, D.

2017-12-01

While MAVEN have been observing the space weather conditions driven by ICMEs and SEPs in orbit around Mars, MSL/RAD have been measuring the surface radiation environment due to E > 150 MeV/nuc SEPs and the higher-energy galactic cosmic rays. The suite of MAVEN instruments measuring the particles (SEP), plasma (SWIA) and fields (MAG) information provides detailed local space weather information regarding the solar activity-related fluctuations in the measured surface dose rates. At the same time, the related enhancements in the RAD surface dose rates indicate the degree to which the SEPs affect the lower atmosphere and surface. We will present an overview of the MAVEN observations together with the MSL/RAD measurements and focus our discussion on a number of space weather events driven by CMEs and SEPs. During the March 2015 solar storm period, a succession of CMEs produced intense SEP proton fluxes that were detected by MAVEN/SEP in the 20 keV to 6 MeV detected energy channels. At higher energies, MAVEN/SEP record `FTO' SEP events that were triggered by > 13 MeV energetic protons passing through all three silicon detector layers (Front, Thick, and Open). Using the detector response matrix for an FTO event (incident energy vs detected energy), the minimum incident energy of the SEP protons observed in March 2015 was inferred to be > 40 MeV. The lack of any notable enhancements in the surface dose rate by MSL/RAD suggests that the highest incident energies of the SEP protons were 150 MeV SEP protons impacted the Martian atmosphere and surface. The source of the October 2015 SEP event was probably the CME that erupted near the solar west limb with respect to the Sun-Mars line. As part of the discussion, we will also show solar-heliospheric observations from near-Earth assets together with WSA-Enlil-cone results for some global heliospheric context.

Simulations of the observation of clouds and aerosols with the Experimental Lidar in Space Equipment system.

Science.gov (United States)

Liu, Z; Voelger, P; Sugimoto, N

2000-06-20

We carried out a simulation study for the observation of clouds and aerosols with the Japanese Experimental Lidar in Space Equipment (ELISE), which is a two-wavelength backscatter lidar with three detection channels. The National Space Development Agency of Japan plans to launch the ELISE on the Mission Demonstrate Satellite 2 (MDS-2). In the simulations, the lidar return signals for the ELISE are calculated for an artificial, two-dimensional atmospheric model including different types of clouds and aerosols. The signal detection processes are simulated realistically by inclusion of various sources of noise. The lidar signals that are generated are then used as input for simulations of data analysis with inversion algorithms to investigate retrieval of the optical properties of clouds and aerosols. The results demonstrate that the ELISE can provide global data on the structures and optical properties of clouds and aerosols. We also conducted an analysis of the effects of cloud inhomogeneity on retrievals from averaged lidar profiles. We show that the effects are significant for space lidar observations of optically thick broken clouds.

Distributed Space Mission Design for Earth Observation Using Model-Based Performance Evaluation

Science.gov (United States)

Nag, Sreeja; LeMoigne-Stewart, Jacqueline; Cervantes, Ben; DeWeck, Oliver

2015-01-01

Distributed Space Missions (DSMs) are gaining momentum in their application to earth observation missions owing to their unique ability to increase observation sampling in multiple dimensions. DSM design is a complex problem with many design variables, multiple objectives determining performance and cost and emergent, often unexpected, behaviors. There are very few open-access tools available to explore the tradespace of variables, minimize cost and maximize performance for pre-defined science goals, and therefore select the most optimal design. This paper presents a software tool that can multiple DSM architectures based on pre-defined design variable ranges and size those architectures in terms of predefined science and cost metrics. The tool will help a user select Pareto optimal DSM designs based on design of experiments techniques. The tool will be applied to some earth observation examples to demonstrate its applicability in making some key decisions between different performance metrics and cost metrics early in the design lifecycle.

Programme of Indian Centre for Space Physics using Very Low Frequency Radio Waves

Science.gov (United States)

Chakrabarti, Sandip Kumar; Sasmal, Sudipta; Pal, Sujay; Kanta Maji, Surya; Ray, Suman

Indian Centre for Space Physics conducted two major VLF campaigns all over Indian Sub-continent to study the propagation effects of VLF radio waves. It made multi-receiver observations during solar eclipse. ICSP not only recorded multitudes of solar flares, it also reproduced VLF observation from ab initio calculation. ICSP extended its study to the field of earthquake predictions using signal anomalies and using case by case studies as well as statistical analysis, showed that anomalies are real and more studies are required to understand them. Using earth as a gigantic detector, it detected ionospheric perturbations due to soft gamma-ray repeaters and gamma-ray bursts.

Does emotion modulate the efficacy of spaced learning in recognition memory?

Directory of Open Access Journals (Sweden)

Nicola Mammarella

2014-12-01

Full Text Available Memory for repeated items improves when presentations are spaced during study. Here, two experiments assessed the so-called spacing effect on a yes–no recognition memory task using affective and neutral words. In Experiment 1, a group of participants was asked to orient their attention to semantic features of target words (deep semantic analysis that were consecutively repeated or spaced, while another group was engaged in a graphemic shallow analysis of words (Experiment 2. The depth of word processing approach was meant to highlight the role of repetition priming mechanisms in the generation of spacing effects. We found that spacing effects occurred for both affective and neutral words (Experiment 1. However, following shallow analysis of words, the spacing effect was reduced for both affective and neutral words (Experiment 2. No differences were detected in terms of positive versus negative words. These results suggest that spaced learning operates when the to-be-remembered material is also affectively charged and that, under certain circumstances, it may enhance recognition memory as affective connotation does.

Repeated Solid-state Dewetting of Thin Gold Films for Nanogap-rich Plasmonic Nanoislands.

Science.gov (United States)

Kang, Minhee; Park, Sang-Gil; Jeong, Ki-Hun

2015-10-15

This work reports a facile wafer-level fabrication for nanogap-rich gold nanoislands for highly sensitive surface enhanced Raman scattering (SERS) by repeating solid-state thermal dewetting of thin gold film. The method provides enlarged gold nanoislands with small gap spacing, which increase the number of electromagnetic hotspots and thus enhance the extinction intensity as well as the tunability for plasmon resonance wavelength. The plasmonic nanoislands from repeated dewetting substantially increase SERS enhancement factor over one order-of-magnitude higher than those from a single-step dewetting process and they allow ultrasensitive SERS detection of a neurotransmitter with extremely low Raman activity. This simple method provides many opportunities for engineering plasmonics for ultrasensitive detection and highly efficient photon collection.

Gene conversion homogenizes the CMT1A paralogous repeats

Directory of Open Access Journals (Sweden)

Hurles Matthew E

2001-12-01

Full Text Available Abstract Background Non-allelic homologous recombination between paralogous repeats is increasingly being recognized as a major mechanism causing both pathogenic microdeletions and duplications, and structural polymorphism in the human genome. It has recently been shown empirically that gene conversion can homogenize such repeats, resulting in longer stretches of absolute identity that may increase the rate of non-allelic homologous recombination. Results Here, a statistical test to detect gene conversion between pairs of non-coding sequences is presented. It is shown that the 24 kb Charcot-Marie-Tooth type 1A paralogous repeats (CMT1A-REPs exhibit the imprint of gene conversion processes whilst control orthologous sequences do not. In addition, Monte Carlo simulations of the evolutionary divergence of the CMT1A-REPs, incorporating two alternative models for gene conversion, generate repeats that are statistically indistinguishable from the observed repeats. Bounds are placed on the rate of these conversion processes, with central values of 1.3 × 10-4 and 5.1 × 10-5 per generation for the alternative models. Conclusions This evidence presented here suggests that gene conversion may have played an important role in the evolution of the CMT1A-REP paralogous repeats. The rates of these processes are such that it is probable that homogenized CMT1A-REPs are polymorphic within modern populations. Gene conversion processes are similarly likely to play an important role in the evolution of other segmental duplications and may influence the rate of non-allelic homologous recombination between them.

Observation and simulation of space-charge effects in a radio-frequency photoinjector using a transverse multibeamlet distribution

Directory of Open Access Journals (Sweden)

M. Rihaoui

2009-12-01

Full Text Available We report on an experimental study of space-charge effects in a radio-frequency (rf photoinjector. A 5 MeV electron bunch, consisting of a number of beamlets separated transversely, was generated in an rf photocathode gun and propagated in the succeeding drift space. The collective interaction of these beamlets was studied for different experimental conditions. The experiment allowed the exploration of space-charge effects and its comparison with 3D particle-in-cell simulations. Our observations also suggest the possible use of a multibeam configuration to tailor the transverse distribution of an electron beam.

Quiet but still bright: XMM-Newton observations of the soft gamma-ray repeater SGR 0526-66

NARCIS (Netherlands)

Tiengo, A.; Esposito, P.; Mereghetti, S.; Israel, G.L.; Stella, L.; Turolla, R.; Zane, S.; Rea, N.; Götz, D.; Feroci, M.

2009-01-01

SGR 0526-66 was the first soft gamma-ray repeater (SGR) from which a giant flare was detected in March 1979, suggesting the existence of magnetars, i.e. neutron stars powered by the decay of their extremely strong magnetic field. Since then, very little information has been obtained on this object,

DISCOVERY OF A NEW SOFT GAMMA REPEATER: SGR J0418 + 5729

International Nuclear Information System (INIS)

Van der Horst, A. J.; Connaughton, V.; Briggs, M. S.; Kouveliotou, C.; Goegues, E.; Kaneko, Y.; Wachter, S.; Granot, J.; Ramirez-Ruiz, E.; Woods, P. M.; Aptekar, R. L.; Frederiks, D. D.; Golenetskii, S.; Barthelmy, S. D.; Cummings, J. R.; Gehrels, N.; Finger, M. H.; Gelino, C. R.; Gelino, D. M.; Hurley, K.

2010-01-01

On 2009 June 5, the Gamma-ray Burst Monitor (GBM) onboard the Fermi Gamma-ray Space Telescope triggered on two short and relatively dim bursts with spectral properties similar to soft gamma repeater (SGR) bursts. Independent localizations of the bursts by triangulation with the Konus-RF and with the Swift satellite confirmed their origin from the same, previously unknown, source. The subsequent discovery of X-ray pulsations with the Rossi X-ray Timing Explorer confirmed the magnetar nature of the new source, SGR J0418 + 5729. We describe here the Fermi/GBM observations, the discovery and the localization of this new SGR, and our infrared and Chandra X-ray observations. We also present a detailed temporal and spectral study of the two GBM bursts. SGR J0418 + 5729 is the second source discovered in the same region of the sky in the last year, the other one being SGR J0501 + 4516. Both sources lie in the direction of the galactic anti-center and presumably at the nearby distance of ∼2 kpc (assuming they reside in the Perseus arm of our Galaxy). The near-threshold GBM detection of bursts from SGR J0418 + 5729 suggests that there may be more such 'dim' SGRs throughout our Galaxy, possibly exceeding the population of 'bright' SGRs. Finally, using sample statistics, we conclude that the number of observable active magnetars in our Galaxy at any given time is ∼<10, in agreement with our earlier estimates.

SMM hard X-ray observations of the soft gamma-ray repeater 1806-20

Science.gov (United States)

Kouveliotou, C.; Norris, J. P.; Cline, T. L.; Dennis, B. R.; Desai, U. D.; Orwig, L. E.

1987-01-01

Six bursts from the soft gamma-ray repeater (SGR) 1806-20 have been recorded with the SMM Hard X-ray Burst Spectrometer during a highly active phase in 1983. Rise and decay times of less than 5 ns have been detected. Time profiles of these events indicate low-level emission prior to and after the main peaks. The results suggest that SGRs are distinguished from classical gamma-ray bursts by repetition, softer nonvarying spectra, short durations, simple temporal profiles, and a tendency for source locations to correlate with Population I objects. SGR characteristics differ from those of type I X-ray bursts, but they appear to have similarities with the type II bursts from the Rapid Burster.

SMM hard X-ray observations of the soft gamma-ray repeater 1806-20

International Nuclear Information System (INIS)

Kouveliotou, C.; Norris, J.P.; Cline, T.L.; Dennis, B.R.; Desai, U.D.; Orwig, L.E.

1987-01-01

Six bursts from the soft gamma-ray repeater (SGR) 1806-20 have been recorded with the SMM Hard X-ray Burst Spectrometer during a highly active phase in 1983. Rise and decay times of less than 5 ns have been detected. Time profiles of these events indicate low-level emission prior to and after the main peaks. The results suggest that SGRs are distinguished from classical gamma-ray bursts by repetition, softer nonvarying spectra, short durations, simple temporal profiles, and a tendency for source locations to correlate with Population I objects. SGR characteristics differ from those of type I X-ray bursts, but they appear to have similarities with the type II bursts from the Rapid Burster. 19 references

78 FR 65594 - Vehicular Repeaters

Science.gov (United States)

2013-11-01

... coordinators estimate the effect on coordination fees? Does the supposed benefit that mobile repeater stations... allow the licensing and operation of vehicular repeater systems and other mobile repeaters by public... email: [email protected] or phone: 202-418- 0530 or TTY: 202-418-0432. For detailed instructions for...

Time biases in laser ranging observations: A concerning issue of Space Geodesy

Science.gov (United States)

Exertier, Pierre; Belli, A.; Lemoine, J. M.

2017-09-01

Time transfer by Laser Ranging (LR) recently demonstrated a remarkable stability (a few ps over ∼1000 s) and accuracy (synchronizing both space and ground clocks over distances from a few thousands to tens of thousands kilometers. Given its potential role in navigation, fundamental physics and metrology, it is crucial that synergy between laser ranging and Time&Frequency (T/F) technologies improves to meet the present and future space geodesy requirements. In this article, we examine the behavior of T/F systems that are used in LR tracking stations of the international laser ranging service. The approach we investigate is to compute time synchronization between clocks used at LR stations using accurate data of the Time Transfer by Laser Link (T2L2) experiment onboard the satellite Jason-2 (Samain et al., 2014). Systematic time biases are estimated against the UTC time scale for a set of 22 observing stations in 2013, in the range of zero to a few μ s. Our results suggest that the ILRS network suffers from accuracy issues, due to time biases in the laser ranging observations. We discuss how these systematic effects impact the precise orbit determination of LAGEOS geodetic satellites over a 1-year analysis, and additionally give a measure of the local effect into station coordinates, regarding in particular the effect in the east-west component that is of 2-6 mm for a typical systematic time bias of one μ s.

Characteristics of intergenerational contractions of the CTG repeat in myotonic dystropy

Energy Technology Data Exchange (ETDEWEB)

Ashizawa, T.; Anvret, M.; Grandell, U.; Baiget, M.; Cobo, A.M.; Barcelo, J.M.; Korneluk, R.G.; Dallapiccola, B.; Novelli, G.; Fenwick, R.G. Jr. (and others)

1994-03-01

In myotonic dystropy (DM), the size of a CTG repeat in the DM kinase gene generally increases in successive generations with clinical evidence of anticipation. However, there have also been cases with an intergenerational contraction of the repeat. The authors have examined 1,489 DM parent-offspring pairs, of which 95 (6.4%) showed such contractions in peripheral blood leukocytes (PBL). In 56 of th 95 pairs, clinical data allowed an analysis of their anticipation status. It is surprising that anticipation occurred in 27 (48%) of these 56 pairs, while none clearly showed a later onset of DM in the asymptomatic offspring. The contraction occurred in 76 (10%) of 753 paternal transmission and in 19 (3%) of 736 maternal transmissions. Anticipation was observed more frequently in maternal (85%) than in paternal (37%) transmissions (P<.001). The parental repeat size correlated with the size of intergenerational contraction (r[sup 2] = .50, P [much lt].001), and the slope of linear regression was steeper in paternal ([minus].62) than in maternal ([minus].30) transmissions (P [much lt].001). Sixteen DM parents had multiple DM offspring with the CTG repeat contractions. This frequency was higher than the frequency expected from the probability of the repeat contractions (6.4%) and the size of DM sib population (1.54 DM offspring per DM parent, in 968 DM parents). The authors conclude that (1) intergenerational contraction of the CTG repeat in leukocyte DNA frequently accompanies apparent anticipation, especially when DM is maternally transmitted, and (2) the paternal origin of the repeat and the presence of the repeat contraction in a sibling increase the probability of the CTG repeat contraction. 43 refs., 1 fig., 4 tabs.

Tevatron serial data repeater system

International Nuclear Information System (INIS)

Ducar, R.J.

1981-01-01

A ten megabit per second serial data repeater system has been developed for the 6.28km Tevatron accelerator. The repeaters are positioned at each of the thirty service buildings and accommodate control and abort system communications as well as distribution of the Tevatron time and energy clocks. The repeaters are transparent to the particular protocol of the transmissions. Serial data are encoded locally as unipolar two volt signals employing the self-clocking Manchester Bi-Phase code. The repeaters modulate the local signals to low-power bursts of 50 MHz rf carrier for the 260m transmission between service buildings. The repeaters also demodulate the transmission and restructure the data for local utilization. The employment of frequency discrimination techniques yields high immunity to the characteristic noise spectrum

Repeat Customer Success in Extension

Science.gov (United States)

Bess, Melissa M.; Traub, Sarah M.

2013-01-01

Four multi-session research-based programs were offered by two Extension specialist in one rural Missouri county. Eleven participants who came to multiple Extension programs could be called "repeat customers." Based on the total number of participants for all four programs, 25% could be deemed as repeat customers. Repeat customers had…

Film repeats in radiology department

International Nuclear Information System (INIS)

Suwan, A. Z.; Al-Shakharah, A. I

1997-01-01

During a one year period, 4910 radiographs of 55780 films were repeated. The objective of our study was to analyse and to classify the causes in order to minimize the repeats, cut the expenses and to provide optimal radiographs for accurate diagnosis. Analysis of the different factors revealed that, 43.6% of film repeats in our service were due to faults in exposure factors, centering comprises 15.9% of the repeats, while too much collimation was responsible for 7.6% of these repeats. All of which can be decreased by awareness and programmed training of technicians. Film blurring caused by patient motion was also responsible for 4.9% for radiographs reexamination, which can be minimized by detailed explanation to the patient and providing the necessary privacy. Fogging of X-Ray films by improper storage or inadequate handling or processing faults were responsible for 14.5% in repeats in our study. Methods and criteria for proper storage and handling of films were discussed. Recommendation for using modern day-light and laser processor has been high lighted. Artefacts are noticeably high in our cases, due to spinal dresses and frequent usage of precious metals for c osmotic purposes in this part of the world. The repeated films comprise 8.8% of all films We conclude that, the main factor responsible for repeats of up to 81.6% of cases was the technologists, thus emphasizing the importance of adequate training of the technologists. (authors). 15 refs., 9 figs., 1 table

Observations of the orbital debris complex by the Midcourse Space Experiment (MSX) satellite

Science.gov (United States)

Vilas, Faith; Anz-Meador, Phillip; Talent, Dave

1997-01-01

The midcourse space experiment (MSX) provides the opportunity to observe debris at multiple, simultaneous wavelengths, or in conjunction with other sensors and prior data sets. The instruments onboard MSX include an infrared telescope, an infrared interferometer, a visible telescope, an ultraviolet telescope and a spectroscopic imager. The spacecraft carries calibration spheres for instrument calibration and atmospheric drag studies. The experimental program, the implementation aspects, the data reduction techniques and the preliminary results are described.

Repeat migration and disappointment.

Science.gov (United States)

Grant, E K; Vanderkamp, J

1986-01-01

This article investigates the determinants of repeat migration among the 44 regions of Canada, using information from a large micro-database which spans the period 1968 to 1971. The explanation of repeat migration probabilities is a difficult task, and this attempt is only partly successful. May of the explanatory variables are not significant, and the overall explanatory power of the equations is not high. In the area of personal characteristics, the variables related to age, sex, and marital status are generally significant and with expected signs. The distance variable has a strongly positive effect on onward move probabilities. Variables related to prior migration experience have an important impact that differs between return and onward probabilities. In particular, the occurrence of prior moves has a striking effect on the probability of onward migration. The variable representing disappointment, or relative success of the initial move, plays a significant role in explaining repeat migration probabilities. The disappointment variable represents the ratio of actural versus expected wage income in the year after the initial move, and its effect on both repeat migration probabilities is always negative and almost always highly significant. The repeat probabilities diminish after a year's stay in the destination region, but disappointment in the most recent year still has a bearing on the delayed repeat probabilities. While the quantitative impact of the disappointment variable is not large, it is difficult to draw comparisons since similar estimates are not available elsewhere.

Repeated isoflurane exposure and neuroapoptosis in the midgestation fetal sheep brain.

Science.gov (United States)

Olutoye, Olutoyin A; Sheikh, Fariha; Zamora, Irving J; Yu, Ling; Akinkuotu, Adesola C; Adesina, Adekunle M; Olutoye, Oluyinka O

2016-04-01

Advances in surgery and technology have resulted in increased in-utero procedures. However, the effect of anesthesia on the fetal brain is not fully known. The inhalational anesthetic agent, isoflurane, other gamma amino butyric acid agonists (benzodiazepines, barbiturates, propofol, other inhalation anesthetics), and N-methyl D aspartate antagonists, eg, ketamine, have been shown to induce neuroapoptosis. The ovine model has been used extensively to study maternal-fetal physiologic interactions and to investigate different surgical interventions on the fetus. The purpose of this study was to determine effects of different doses and duration of isoflurane on neuroapoptosis in midgestation fetal sheep. We hypothesized that repeated anesthetic exposure and high concentrations of isoflurane would result in increased neuroapoptosis. Time-dated, pregnant sheep at 70 days gestation (term 145 days) received either isoflurane 2% × 1 hour, 4% × 3 hours, or 2% × 1 hour every other day for 3 exposures (repeated exposure group). Euthanasia occurred following anesthetic exposure and fetal brains were processed. Neuroapoptosis was detected by immunohistochemistry using anticaspase-3 antibodies. Fetuses unexposed to anesthesia served as controls. Another midgestation group with repeated 2% isoflurane exposure was examined at day 130 (long-term group) and neuronal cell density compared to age-matched controls. Representative sections of the brain were analyzed using Aperio Digital imaging (Leica Microsystems Inc, Buffalo Grove, IL). Data, reported by number of neurons per cubic millimeter of brain tissue are presented as means and SEM. Data were analyzed using the Mann-Whitney U and Kruskal-Wallis tests as appropriate. A total of 34 fetuses were studied. There was no significant difference in neuroapoptosis observed in fetuses exposed to 2% isoflurane for 1 hour or 4% isoflurane for 3 hours. Increased neuroapoptosis was observed in the frontal cortex following repeated 2

Quantum repeated games revisited

International Nuclear Information System (INIS)

Frąckiewicz, Piotr

2012-01-01

We present a scheme for playing quantum repeated 2 × 2 games based on Marinatto and Weber’s approach to quantum games. As a potential application, we study the twice repeated Prisoner’s Dilemma game. We show that results not available in the classical game can be obtained when the game is played in the quantum way. Before we present our idea, we comment on the previous scheme of playing quantum repeated games proposed by Iqbal and Toor. We point out the drawbacks that make their results unacceptable. (paper)

Repeated mild traumatic brain injury in female rats increases lipid peroxidation in neurons.

Science.gov (United States)

Yates, Nathanael J; Lydiard, Stephen; Fehily, Brooke; Weir, Gillian; Chin, Aaron; Bartlett, Carole A; Alderson, Jacqueline; Fitzgerald, Melinda

2017-07-01

Negative outcomes of mild traumatic brain injury (mTBI) can be exacerbated by repeated insult. Animal models of repeated closed-head mTBI provide the opportunity to define acute pathological mechanisms as the number of mTBI increases. Furthermore, little is known about the effects of mTBI impact site, and how this may affect brain function. We use a closed head, weight drop model of mTBI that allows head movement following impact, in adult female rats to determine the role of the number and location of mTBI on brain pathology and behaviour. Biomechanical assessment of two anatomically well-defined mTBI impact sites were used, anterior (bregma) and posterior (lambda). Location of the impact had no significant effect on impact forces (450 N), and the weight impact locations were on average 5.4 mm from the desired impact site. No between location vertical linear head kinematic differences were observed immediately following impact, however, in the 300 ms post-impact, significantly higher mean vertical head displacement and velocity were observed in the mTBI lambda trials. Breaches of the blood brain barrier were observed with three mTBI over bregma, associated with immunohistochemical indicators of damage. However, an increased incidence of hairline fractures of the skull and macroscopic haemorrhaging made bregma an unsuitable impact location to model repeated mTBI. Repeated mTBI over lambda did not cause skull fractures and were examined more comprehensively, with outcomes following one, two or three mTBI or sham, delivered at 1 day intervals, assessed on days 1-4. We observe a mild behavioural phenotype, with subtle deficits in cognitive function, associated with no identifiable neuroanatomical or inflammatory changes. However, an increase in lipid peroxidation in a subset of cortical neurons following two mTBI indicates increasing oxidative damage with repeated injury in female rats, supported by increased amyloid precursor protein immunoreactivity with three m

Observing the Anthropocene from Space: Challenges and Needs

Science.gov (United States)

Burrows, John

2016-07-01

The rapid growth of human population since the industrial revolution has been coupled with a much increased standard of living and bountiful production of food. The dominant energy source sustaining this development has been fossil fuel combustion. However this has resulted in pollution which now spans all scales. There have significant impacts on air quality, water quality, stratospheric ozone and climate. The impacts can sudden and large and also slowly accumulate over time in the long term. The first decades of the space age resulted in pioneering efforts to establish adequate measurement capability. This process is continuing to evolve. Over the past two decades there have been a number of efforts to define the contribution and needs for a space segment which can separate anthropogenic form natural changes in the earth system. This talk introduces this topic of the use of the space segment to deconvolve change from anthropogenic activity and natural phenomena.

New algorithms for optical observations of space debris with the TAROT telescopes

Science.gov (United States)

Laas-Bourez, Myrtille; Boer, Michel; Blanchet, Gwendoline; Ducrotte, Etienne; Klotz, Alain

To preserve the space environment for the future, and to make space expedition safe, we have to improve our knowledge of the debris population in the vicinity of the geostationary orbit. Since 2004, CNES observes satellites in the geostationary orbit with a network of robotic ground based fully automated telescopes. One is located in France and the second being in ESO La Silla, Chile. This system makes real time processing and its wide field of view is useful for detection, systematic survey and tracking both catalogued and uncatalogued objets. We are implementing new, more efficient, image processing algorithms. A new source extraction algorithm based on morphological mathematic, and a "matching-pursuit" algorithm allow to correlate the measurements of the same object on successive images and give an almost nil false detection rate. These new methods allow us to detect objects on the geostationary belt and on other orbits like MEO or GTO. We also improved the timing precision of individual images (few milliseconds) and the precision of the position restitution respective to the celestial frame. Our "delay card" provides an extremely precise date of objects in a picture and our new algorithm accurately extracts stars from background for calibration; Thanks to all these improvements, the overall efficiency and quality of the survey of the geostationary orbit has drastically improved and we can now detect satellites and debris in different orbits like GTO orbit. In this paper we present our new methods and the work we have made for the detection of space debris: the images dating with a card of delay, the accuracy of astronomical calibration, and the robustness of the extracting space debris with different algorithms. The results obtained on the sky will be shown.

Repeated treatments of drooling with botulinum toxin B in neurology

DEFF Research Database (Denmark)

Møller, Eigild; Daugaard, Dorthe; Holm, Ole

2015-01-01

OBJECTIVES: To investigate efficacy, saliva flow, and composition in repeated BoNT-B treatments of drooling. MATERIALS AND METHODS: Seventeen neurological patients (median 66 years), referred for treatment of drooling participated in this observational study. Median total doses of 4000 units...

Tumorigenic responses from single or repeated inhalation exposures to relatively insoluble aerosols of Ce-144

International Nuclear Information System (INIS)

Boecker, B.B.; Hahn, F.F.; Mauderly, J.L.; McClellan, R.O.

1980-01-01

Human occupational or environmental inhalation exposures may involve repeated or chronic exposures, but most laboratory studies of inhaled radionuclides have involved single exposures. This study was designed to compare the biological effects of repeated inhalation exposures of dogs to a relatively insoluble form of 144 Ce with existing data for singly-exposed dogs that had the same cumulative dose to the lungs two years after exposure. To date, the biological effects observed in these repeatedly-exposed dogs have been substantially different from those seen in singly-exposed dogs, particularly during the first 5 years after the initial exposure. Although pulmonary hemangiosarcoma was the prominent biological effect seen in singly-exposed dogs between 2 and 4 years after exposure, no lung tumors were seen during the 5 years after the first of the repeated exposures. This response plus other clinical observations are discussed in relation to the patterns of dose rate and cumulative dose for the different exposure conditions. (H.K.)

Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder.

Science.gov (United States)

Ramos, Eliana Marisa; Gillis, Tammy; Mysore, Jayalakshmi S; Lee, Jong-Min; Alonso, Isabel; Gusella, James F; Smoller, Jordan W; Sklar, Pamela; MacDonald, Marcy E; Perlis, Roy H

2015-06-01

Huntington's disease is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms that are caused by huntingtin gene (HTT) CAG trinucleotide repeat alleles of 36 or more units. A greater than expected prevalence of incompletely penetrant HTT CAG repeat alleles observed among individuals diagnosed with major depressive disorder raises the possibility that another mood disorder, bipolar disorder, could likewise be associated with Huntington's disease. We assessed the distribution of HTT CAG repeat alleles in a cohort of individuals with bipolar disorder. HTT CAG allele sizes from 2,229 Caucasian individuals diagnosed with DSM-IV bipolar disorder were compared to allele sizes in 1,828 control individuals from multiple cohorts. We found that HTT CAG repeat alleles > 35 units were observed in only one of 4,458 chromosomes from individuals with bipolar disorder, compared to three of 3,656 chromosomes from control subjects. These findings do not support an association between bipolar disorder and Huntington's disease. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Phase space properties of local observables and structure of scaling limits

International Nuclear Information System (INIS)

Buchholz, D.

1995-05-01

For any given algebra of local observables in relativistic quantum field theory there exists an associated scaling algebra which permits one to introduce renormalization group transformations and to construct the scaling (short distance) limit of the theory. On the basis of this result it is discussed how the phase space properties of a theory determine the structure of its scaling limit. Bounds on the number of local degrees of freedom appearing in the scaling limit are given which allow one to distinguish between theories with classical and quantum scaling limits. The results can also be used to establish physically significant algebraic properties of the scaling limit theories, such as the split property. (orig.)

Spacing and Induction: Application to Exemplars Presented as Auditory and Visual Text

Science.gov (United States)

Zulkiply, Norehan; McLean, John; Burt, Jennifer S.; Bath, Debra

2012-01-01

It is an established finding that spacing repetitions generally facilitates memory for the repeated events. However, the effect of spacing of exemplars on inductive learning is not really known. Two experiments using textual material were conducted to investigate the effect of spacing on induction. Experiment 1 and 2 extended the generality of…

Storm-time radiation belt electron dynamics: Repeatability in the outer radiation belt

Science.gov (United States)

Murphy, K. R.; Mann, I. R.; Rae, J.; Watt, C.; Boyd, A. J.; Turner, D. L.; Claudepierre, S. G.; Baker, D. N.; Spence, H. E.; Reeves, G. D.; Blake, J. B.; Fennell, J. F.

2017-12-01

During intervals of enhanced solar wind driving the outer radiation belt becomes extremely dynamic leading to geomagnetic storms. During these storms the flux of energetic electrons can vary by over 4 orders of magnitude. Despite recent advances in understanding the nature of competing storm-time electron loss and acceleration processes the dynamic behavior of the outer radiation belt remains poorly understood; the outer radiation belt can exhibit either no change, an enhancement, or depletion in radiation belt electrons. Using a new analysis of the total radiation belt electron content, calculated from the Van Allen probes phase space density (PSD), we statistically analyze the time-dependent and global response of the outer radiation belt during storms. We demonstrate that by removing adiabatic effects there is a clear and repeatable sequence of events in storm-time radiation belt electron dynamics. Namely, the relativistic (μ=1000 MeV/G) and ultra-relativistic (μ=4000 MeV/G) electron populations can be separated into two phases; an initial phase dominated by loss followed by a second phase dominated by acceleration. At lower energies, the radiation belt seed population of electrons (μ=150 MeV/G) shows no evidence of loss but rather a net enhancement during storms. Further, we investigate the dependence of electron dynamics as a function of the second adiabatic invariant, K. These results demonstrate a global coherency in the dynamics of the source, relativistic and ultra-relativistic electron populations as function of the second adiabatic invariant K. This analysis demonstrates two key aspects of storm-time radiation belt electron dynamics. First, the radiation belt responds repeatably to solar wind driving during geomagnetic storms. Second, the response of the radiation belt is energy dependent, relativistic electrons behaving differently than lower energy seed electrons. These results have important implications in radiation belt research. In particular

Myotonin protein-kinase [AGC]n trinucleotide repeat in seven nonhuman primates

Energy Technology Data Exchange (ETDEWEB)

Novelli, G.; Sineo, L.; Pontieri, E. [Catholic Univ. of Rome (Italy)]|[Univ. of Milan (Italy)]|[Univ. Florence (Italy)] [and others

1994-09-01

Myotonic dystrophy (DM) is due to a genomic instability of a trinucleotide [AGC]n motif, located at the 3{prime} UTR region of a protein-kinase gene (myotonin protein kinase, MT-PK). The [AGC] repeat is meiotically and mitotically unstable, and it is directly related to the manifestations of the disorder. Although a gene dosage effect of the MT-PK has been demonstrated n DM muscle, the mechanism(s) by which the intragenic repeat expansion leads to disease is largely unknown. This non-standard mutational event could reflect an evolutionary mechanism widespread among animal genomes. We have isolated and sequenced the complete 3{prime}UTR region of the MT-PK gene in seven primates (macaque, orangutan, gorilla, chimpanzee, gibbon, owl monkey, saimiri), and examined by comparative sequence nucleotide analysis the [AGC]n intragenic repeat and the surrounding nucleotides. The genomic organization, including the [AGC]n repeat structure, was conserved in all examined species, excluding the gibbon (Hylobates agilis), in which the [AGC]n upstream sequence (GGAA) is replaced by a GA dinucleotide. The number of [AGC]n in the examined species ranged between 7 (gorilla) and 13 repeats (owl monkeys), with a polymorphism informative content (PIC) similar to that observed in humans. These results indicate that the 3{prime}UTR [AGC] repeat within the MT-PK gene is evolutionarily conserved, supporting that this region has important regulatory functions.

Repeatability of visual acuity measurement.

Science.gov (United States)

Raasch, T W; Bailey, I L; Bullimore, M A

1998-05-01

This study investigates features of visual acuity chart design and acuity testing scoring methods which affect the validity and repeatability of visual acuity measurements. Visual acuity was measured using the Sloan and British Standard letter series, and Landolt rings. Identifiability of the different letters as a function of size was estimated, and expressed in the form of frequency-of-seeing curves. These functions were then used to simulate acuity measurements with a variety of chart designs and scoring criteria. Systematic relationships exist between chart design parameters and acuity score, and acuity score repeatability. In particular, an important feature of a chart, that largely determines the repeatability of visual acuity measurement, is the amount of size change attributed to each letter. The methods used to score visual acuity performance also affect repeatability. It is possible to evaluate acuity score validity and repeatability using the statistical principles discussed here.

A General Model for Repeated Audit Controls Using Monotone Subsampling

NARCIS (Netherlands)

Raats, V.M.; van der Genugten, B.B.; Moors, J.J.A.

2002-01-01

In categorical repeated audit controls, fallible auditors classify sample elements in order to estimate the population fraction of elements in certain categories.To take possible misclassifications into account, subsequent checks are performed with a decreasing number of observations.In this paper a

Peripheral and central effects of repeated social defeat stress: monocyte trafficking, microglial activation, and anxiety.

Science.gov (United States)

Reader, B F; Jarrett, B L; McKim, D B; Wohleb, E S; Godbout, J P; Sheridan, J F

2015-03-19

The development and exacerbation of depression and anxiety are associated with exposure to repeated psychosocial stress. Stress is known to affect the bidirectional communication between the nervous and immune systems leading to elevated levels of stress mediators including glucocorticoids (GCs) and catecholamines and increased trafficking of proinflammatory immune cells. Animal models, like the repeated social defeat (RSD) paradigm, were developed to explore this connection between stress and affective disorders. RSD induces activation of the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis activation, increases bone marrow production and egress of primed, GC-insensitive monocytes, and stimulates the trafficking of these cells to tissues including the spleen, lung, and brain. Recently, the observation that these monocytes have the ability to traffic to the brain perivascular spaces and parenchyma have provided mechanisms by which these peripheral cells may contribute to the prolonged anxiety-like behavior associated with RSD. The data that have been amassed from the RSD paradigm and others recapitulate many of the behavioral and immunological phenotypes associated with human anxiety disorders and may serve to elucidate potential avenues of treatment for these disorders. Here, we will discuss novel and key data that will present an overview of the neuroendocrine, immunological and behavioral responses to social stressors. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

Sequence variations in C9orf72 downstream of the hexanucleotide repeat region and its effect on repeat-primed PCR interpretation

DEFF Research Database (Denmark)

Nordin, Angelica; Akimoto, Chizuru; Wuolikainen, Anna

2017-01-01

A large GGGGCC-repeat expansion mutation (HREM) in C9orf72 is the most common known cause of ALS and FTD in European populations. Sequence variations immediately downstream of the HREM region have previously been observed and have been suggested to be one reason for difficulties in interpreting R...

Semi-automated digital image analysis of patellofemoral joint space width from lateral knee radiographs

Energy Technology Data Exchange (ETDEWEB)

Grochowski, S.J. [Mayo Clinic, Department of Orthopedic Surgery, Rochester (United States); Amrami, K.K. [Mayo Clinic, Department of Radiology, Rochester (United States); Kaufman, K. [Mayo Clinic, Department of Orthopedic Surgery, Rochester (United States); Mayo Clinic/Foundation, Biomechanics Laboratory, Department of Orthopedic Surgery, Charlton North L-110L, Rochester (United States)

2005-10-01

To design a semi-automated program to measure minimum patellofemoral joint space width (JSW) using standing lateral view radiographs. Lateral patellofemoral knee radiographs were obtained from 35 asymptomatic subjects. The radiographs were analyzed to report both the repeatability of the image analysis program and the reproducibility of JSW measurements within a 2 week period. The results were also compared with manual measurements done by an experienced musculoskeletal radiologist. The image analysis program was shown to have an excellent coefficient of repeatability of 0.18 and 0.23 mm for intra- and inter-observer measurements respectively. The manual method measured a greater minimum JSW than the automated method. Reproducibility between days was comparable to other published results, but was less satisfactory for both manual and semi-automated measurements. The image analysis program had an inter-day coefficient of repeatability of 1.24 mm, which was lower than 1.66 mm for the manual method. A repeatable semi-automated method for measurement of the patellofemoral JSW from radiographs has been developed. The method is more accurate than manual measurements. However, the between-day reproducibility is higher than the intra-day reproducibility. Further investigation of the protocol for obtaining sequential lateral knee radiographs is needed in order to reduce the between-day variability. (orig.)

Kaluza-Klein-Carmeli Metric from Quaternion-Clifford Space, Lorentz' Force, and Some Observables

Directory of Open Access Journals (Sweden)

Christianto V.

2008-04-01

Full Text Available It was known for quite long time that a quaternion space can be generalized to a Clifford space, and vice versa; but how to find its neat link with more convenient metric form in the General Relativity theory, has not been explored extensively. We begin with a representation of group with non-zero quaternions to derive closed FLRW metric [1], and from there obtains Carmeli metric, which can be extended further to become 5D and 6D metric (which we propose to call Kaluza-Klein-Carmeli metric. Thereafter we discuss some plausible implications of this metric, beyond describing a galaxy’s spiraling motion and redshift data as these have been done by Carmeli and Hartnett [4, 5, 6]. In subsequent section we explain Podkletnov’s rotating disc experiment. We also note possible implications to quantum gravity. Further observations are of course recommended in order to refute or verify this proposition.

Space-borne observation of mesospheric bore by Visible and near Infrared Spectral Imager onboard the International Space Station

Science.gov (United States)

Hozumi, Y.; Saito, A.; Sakanoi, T.; Yamazaki, A.; Hosokawa, K.

2017-12-01

Mesospheric bores were observed by Visible and near Infrared Spectral Imager (VISI) of the ISS-IMAP mission (Ionosphere, Mesosphere, upper Atmosphere and Plasmasphere mapping mission from the International Space Station) in O2 airglow at 762 nm wavelength. The mesospheric bore is moving front of sharp jump followed by undulations or turbulence in the mesopause region. Since previous studies of mesospheric bore were mainly based on ground-based airglow imaging that is limited in field-of-view and observing site, little is known about its horizontal extent and global behavior. Space-borne imaging by ISS-IMAP/VISI provides an opportunity to study the mesospheric bore with a wide field-of-view and global coverage. A mesospheric bore was captured by VISI in two consecutive paths on 9 July 2015 over the south of African continent (48ºS - 54ºS and 15ºE). The wave front aligned with south-north direction and propagated to west. The phase velocity and wave length of the following undulation were estimated to 100 m/s and 30 km, respectively. Those parameters are similar to those reported by previous studies. 30º anti-clockwise rotation of the wave front was recognized in 100 min. Another mesospheric bore was captured on 9 May 2013 over the south Atlantic ocean (35ºS - 43ºS and 24ºW - 1ºE) with more than 2,200 km horizontal extent of wave front. The wave front aligned with southeast-northwest direction. Because the following undulation is recognized in the southwest side of the wave front, it is estimated to propagate to northeast direction. The wave front was modulated with 1,000 km wave length. This modulation implies inhomogeneity of the phase velocity.

Earth observations from space: History, promise, and reality. Executive summary

Science.gov (United States)

1995-01-01

In this report the Committee on Earth Studies (CES), a standing committee of the Space Studies Board (SSB) within the National Research Council (NRC), reviews the recent history (nominally from 1981 to 1995) of the U.S. earth observations programs that serve civilian needs. The principal observations programs examined are those of NASA and the National Oceanic and Atmospheric Administration (NOAA). The Air Force' s Defense Meteorological Satellite Program (DMSP) is discussed, but only from the perspective of its relationship to civil needs and the planned merger with the NOAA polar-orbiting system. The report also reviews the interfaces between the earth observations satellite programs and the major national and international environmental monitoring and research programs. The monitoring and research programs discussed are the U.S. Global Change Research Program (USGCRP), the International Geosphere-Biosphere Program (IGBP), the World Climate Research Program (WCRP), related international scientific campaigns, and operational programs for the sharing and application of environmental data. The purpose of this report is to provide a broad historical review and commentary based on the views of the CES members, with particular emphasis on tracing the lengthy record of advisory committee recommendations. Any individual topic could be the subject of an extended report in its own right. Indeed, extensive further reviews are already under way to that end. If the CES has succeeded in the task it has undertaken. This report will serve as a useful starting point for any such more intensive study. The report is divided into eight chapters: ( I ) an introduction, (2) the evolution of the MTPE, (3) its relationship to the USGCRP, (4) applications of earth observations data, (5) the role that smaller satellites can play in research and operational remote sensing, (6) earth system modeling and information systems, (7) a number of associated activities that contribute to the MTPE

Repeatability of apparent diffusion coefficient and intravoxel incoherent motion parameters at 3.0 Tesla in orbital lesions

Energy Technology Data Exchange (ETDEWEB)

Lecler, Augustin [Fondation Ophtalmologique Adolphe de Rothschild, Department of Radiology, Paris (France); Cardiovascular Research Centre - PARCC, Universite Paris Descartes Sorbonne Paris Cite, INSERM UMR-S970, Paris (France); Savatovsky, Julien; Sadik, Jean-Claude; Charbonneau, Frederique; Berges, Olivier [Fondation Ophtalmologique Adolphe de Rothschild, Department of Radiology, Paris (France); Balvay, Daniel [Cardiovascular Research Centre - PARCC, Universite Paris Descartes Sorbonne Paris Cite, INSERM UMR-S970, Paris (France); Zmuda, Mathieu; Galatoire, Olivier [Fondation Ophtalmologique Adolphe de Rothschild, Department of Orbitopalpebral Surgery, Paris (France); Picard, Herve [Fondation Ophtalmologique Adolphe de Rothschild, Clinical Research Unit, Paris (France); Fournier, Laure [Cardiovascular Research Centre - PARCC, Universite Paris Descartes Sorbonne Paris Cite, INSERM UMR-S970, Paris (France); Universite Paris Descartes Sorbonne Paris Cite, Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges Pompidou, Radiology Department, Paris (France)

2017-12-15

To evaluate repeatability of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters in the orbit. From December 2015 to March 2016, 22 patients were scanned twice using an IVIM sequence with 15b values (0-2,000 s/mm{sup 2}) at 3.0T. Two readers independently delineated regions of interest in an orbital mass and in different intra-orbital and extra-orbital structures. Short-term test-retest repeatability and inter-observer agreement were assessed using the intra-class correlation coefficient (ICC), the coefficient of variation (CV) and Bland-Altman limits of agreements (BA-LA). Test-retest repeatability of IVIM parameters in the orbital mass was satisfactory for ADC and D (mean CV 12% and 14%, ICC 95% and 93%), poor for f and D*(means CV 43% and 110%, ICC 90% and 65%). Inter-observer repeatability agreement was almost perfect in the orbital mass for all the IVIM parameters (ICC = 95%, 93%, 94% and 90% for ADC, D, f and D*, respectively). IVIM appeared to be a robust tool to measure D in orbital lesions with good repeatability, but this approach showed a poor repeatability of f and D*. (orig.)

Repeatability of apparent diffusion coefficient and intravoxel incoherent motion parameters at 3.0 Tesla in orbital lesions

International Nuclear Information System (INIS)

Lecler, Augustin; Savatovsky, Julien; Sadik, Jean-Claude; Charbonneau, Frederique; Berges, Olivier; Balvay, Daniel; Zmuda, Mathieu; Galatoire, Olivier; Picard, Herve; Fournier, Laure

2017-01-01

To evaluate repeatability of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters in the orbit. From December 2015 to March 2016, 22 patients were scanned twice using an IVIM sequence with 15b values (0-2,000 s/mm 2 ) at 3.0T. Two readers independently delineated regions of interest in an orbital mass and in different intra-orbital and extra-orbital structures. Short-term test-retest repeatability and inter-observer agreement were assessed using the intra-class correlation coefficient (ICC), the coefficient of variation (CV) and Bland-Altman limits of agreements (BA-LA). Test-retest repeatability of IVIM parameters in the orbital mass was satisfactory for ADC and D (mean CV 12% and 14%, ICC 95% and 93%), poor for f and D*(means CV 43% and 110%, ICC 90% and 65%). Inter-observer repeatability agreement was almost perfect in the orbital mass for all the IVIM parameters (ICC = 95%, 93%, 94% and 90% for ADC, D, f and D*, respectively). IVIM appeared to be a robust tool to measure D in orbital lesions with good repeatability, but this approach showed a poor repeatability of f and D*. (orig.)

An observation of histological evidence on internal organ damages in mice caused by repeated exposures to motorcycle emissions

Science.gov (United States)

Wardoyo, Arinto Y. P.; Juswono, Unggul P.; Noor, Johan A. E.

2017-05-01

Motor vehicle emissions have been identified as a source of ultrafine particles, which have significant impacts on human health. Repeated and prolonged exposure to ultrafine particles may have a significant association with organ damage. Here, we evaluated the correlation between repeated exposure to ultrafine particles and organ damage in mice. Motorcycle emissions were injected into an exposure chamber with mice for a period of 20 seconds. This treatment was conducted over 10 days. The mice were sacrificed on the 2nd, 4th, 6th, 8th, and 10th days for organ preparations. Based on the results, motorcycle emission exposure caused organ damage in mice, with different severities depending on the organ. The highest damage was found for the lung, followed by the kidney, erythrocytes, and liver.

Fostering repeat donations in Ghana.

Science.gov (United States)

Owusu-Ofori, S; Asenso-Mensah, K; Boateng, P; Sarkodie, F; Allain, J-P

2010-01-01

Most African countries are challenged in recruiting and retaining voluntary blood donors by cost and other complexities and in establishing and implementing national blood policies. The availability of replacement donors who are a cheaper source of blood has not enhanced repeat voluntary donor initiatives. An overview of activities for recruiting and retaining voluntary blood donors was carried out. Donor records from mobile sessions were reviewed from 2002 to 2008. A total of 71,701 blood donations; 45,515 (63.5%) being voluntary donations with 11,680 (25%) repeat donations were collected during the study period. Donations from schools and colleges contributed a steady 60% of total voluntary whilst radio station blood drives increased contribution from 10 to 27%. Though Muslim population is less than 20%, blood collection was above the 30-donation cost-effectiveness threshold with a repeat donation trend reaching 60%. In contrast Christian worshippers provided donations. Repeat donation trends amongst school donors and radio blood drives were 20% and 70% respectively. Repeat donations rates have been variable amongst different blood donor groups in Kumasi, Ghana. The impact of community leaders in propagating altruism cannot be overemphasized. Programs aiming at motivating replacement donors to be repeat donors should be developed and assessed. Copyright 2009 The International Association for Biologicals. All rights reserved.

The repeatability and reproducibility of the BioRID IIg in a repeatable laboratory seat based on a production car seat.

Science.gov (United States)

Hynd, David; Depinet, Paul; Lorenz, Bernd

2013-01-01

The United Nations Economic Commission for Europe Informal Group on GTR No. 7 Phase 2 are working to define a build level for the BioRID II rear impact (whiplash) crash test dummy that ensures repeatable and reproducible performance in a test procedure that has been proposed for future legislation. This includes the specification of dummy hardware, as well as the development of comprehensive certification procedures for the dummy. This study evaluated whether the dummy build level and certification procedures deliver the desired level of repeatability and reproducibility. A custom-designed laboratory seat was made using the seat base, back, and head restraint from a production car seat to ensure a representative interface with the dummy. The seat back was reinforced for use in multiple tests and the recliner mechanism was replaced by an external spring-damper mechanism. A total of 65 tests were performed with 6 BioRID IIg dummies using the draft GTR No.7 sled pulse and seating procedure. All dummies were subject to the build, maintenance, and certification procedures defined by the Informal Group. The test condition was highly repeatable, with a very repeatable pulse, a well-controlled seat back response, and minimal observed degradation of seat foams. The results showed qualitatively reasonable repeatability and reproducibility for the upper torso and head accelerations, as well as for T1 Fx and upper neck Fx . However, reproducibility was not acceptable for T1 and upper neck Fz or for T1 and upper neck My . The Informal Group has not selected injury or seat assessment criteria for use with BioRID II, so it is not known whether these channels would be used in the regulation. However, the ramping-up behavior of the dummy showed poor reproducibility, which would be expected to affect the reproducibility of dummy measurements in general. Pelvis and spine characteristics were found to significantly influence the dummy measurements for which poor reproducibility was

Toxicological characteristics of petroleum products repeated exposure

Directory of Open Access Journals (Sweden)

V.M. Rubin

2015-03-01

Full Text Available Abstract. The ability of petroleum products to initiate cumulative effects was assessed in experimental intragastric admission to male albino rats for one month. The analysis of skin-resorptive effects was performed using "test-tube" method on the skin of rats’ tails. It has been established that petroleum products can penetrate the intact skin and, with repeated admission, cause a general toxic effect. There were reductions bodyweights, the negative effect on the function of the kidneys and liver, changes of hematological parameters, as well as activation of the antioksidatnoy system. Repeated intragastric administration does not lead to the death of the animals testifying to the lack of accumulation capacity for petroleum products at the level of functional mortal effects, the cumulation coefficient being > 5.1. Negative impact on urinary function and hepatobiliary system, changes in hematological parameters and activation of the «lipid peroxidation – antioksidant defense» were observed.

Highly sensitive detection of individual HEAT and ARM repeats with HHpred and COACH.

Science.gov (United States)

Kippert, Fred; Gerloff, Dietlind L

2009-09-24

HEAT and ARM repeats occur in a large number of eukaryotic proteins. As these repeats are often highly diverged, the prediction of HEAT or ARM domains can be challenging. Except for the most clear-cut cases, identification at the individual repeat level is indispensable, in particular for determining domain boundaries. However, methods using single sequence queries do not have the sensitivity required to deal with more divergent repeats and, when applied to proteins with known structures, in some cases failed to detect a single repeat. Testing algorithms which use multiple sequence alignments as queries, we found two of them, HHpred and COACH, to detect HEAT and ARM repeats with greatly enhanced sensitivity. Calibration against experimentally determined structures suggests the use of three score classes with increasing confidence in the prediction, and prediction thresholds for each method. When we applied a new protocol using both HHpred and COACH to these structures, it detected 82% of HEAT repeats and 90% of ARM repeats, with the minimum for a given protein of 57% for HEAT repeats and 60% for ARM repeats. Application to bona fide HEAT and ARM proteins or domains indicated that similar numbers can be expected for the full complement of HEAT/ARM proteins. A systematic screen of the Protein Data Bank for false positive hits revealed their number to be low, in particular for ARM repeats. Double false positive hits for a given protein were rare for HEAT and not at all observed for ARM repeats. In combination with fold prediction and consistency checking (multiple sequence alignments, secondary structure prediction, and position analysis), repeat prediction with the new HHpred/COACH protocol dramatically improves prediction in the twilight zone of fold prediction methods, as well as the delineation of HEAT/ARM domain boundaries. A protocol is presented for the identification of individual HEAT or ARM repeats which is straightforward to implement. It provides high

Earth observations during Space Shuttle Mission STS-42 - Discovery's mission to planet earth

Science.gov (United States)

Lulla, Kamlesh P.; Helfert, Michael; Amsbury, David; Pitts, David; Jaklitch, Pat; Wilkinson, Justin; Evans, Cynthia; Ackleson, Steve; Helms, David; Chambers, Mark

1993-01-01

The noteworthy imagery acquired during Space Shuttle Mission STS-42 is documented. Attention is given to frozen Tibetan lakes, Merapi Volcano in Java, Mt. Pinatubo in the Philippines, the coastline east of Tokyo Japan, land use in southern India, and the Indus River Delta. Observations of Kamchatka Peninsula, Lake Baikal, Moscow, Katmai National Park and Mt. Augustine, Alaska, the Alaskan coast by the Bering Sea, snow-covered New York, the Rhone River valley, the Strait of Gibraltar, and Mt. Ararat, Turkey, are also reported.

Failure mode and effect analysis on safety critical components of space travel

Directory of Open Access Journals (Sweden)

Kouroush Jenab

2015-07-01

Full Text Available Sending men to space has never been an ordinary activity, it requires years of planning and preparation in order to have a chance of success. The payoffs of reliable and repeatable space flight are many, including both Commercial and Military opportunities. In order for reliable and repeatable space flight to become a reality, catastrophic failures need to be detected and mitigated before they occur. It can be shown that small pieces of a design which seem ordinary can create devastating impacts if not designed and tested properly. This paper will address the use of a Failure Mode, Effects, and Criticality Analysis (FMECA with modified Risk Priority Number (RPN and its application to safety critical design components of shuttle liftoff. An example will be presented here which specifically focuses on the Solid Rocket Boosters (SRBs to illustrate the FMECA approach to reliable space travel.

Space Suit Joint Torque Measurement Method Validation

Science.gov (United States)

Valish, Dana; Eversley, Karina

2012-01-01

In 2009 and early 2010, a test method was developed and performed to quantify the torque required to manipulate joints in several existing operational and prototype space suits. This was done in an effort to develop joint torque requirements appropriate for a new Constellation Program space suit system. The same test method was levied on the Constellation space suit contractors to verify that their suit design met the requirements. However, because the original test was set up and conducted by a single test operator there was some question as to whether this method was repeatable enough to be considered a standard verification method for Constellation or other future development programs. In order to validate the method itself, a representative subset of the previous test was repeated, using the same information that would be available to space suit contractors, but set up and conducted by someone not familiar with the previous test. The resultant data was compared using graphical and statistical analysis; the results indicated a significant variance in values reported for a subset of the re-tested joints. Potential variables that could have affected the data were identified and a third round of testing was conducted in an attempt to eliminate and/or quantify the effects of these variables. The results of the third test effort will be used to determine whether or not the proposed joint torque methodology can be applied to future space suit development contracts.

Hubble Space Telescope-NICMOS Observations of M31'S Metal-Rich Globular Clusters and Their Surrounding Fields. I. Techniques

Science.gov (United States)

Stephens, Andrew W.; Frogel, Jay A.; Freedman, Wendy; Gallart, Carme; Jablonka, Pascale; Ortolani, Sergio; Renzini, Alvio; Rich, R. Michael; Davies, Roger

2001-05-01

Astronomers are always anxious to push their observations to the limit-basing results on objects at the detection threshold, spectral features barely stronger than the noise, or photometry in very crowded regions. In this paper we present a careful analysis of photometry in crowded regions and show how image blending affects the results and interpretation of such data. Although this analysis is specifically for our NICMOS observations in M31, the techniques we develop can be applied to any imaging data taken in crowded fields; we show how the effects of image blending will limit even the Next Generation Space Telescope. We have obtained HST-NICMOS observations of five of M31's most metal-rich globular clusters. These data allow photometry of individual stars in the clusters and their surrounding fields. However, to achieve our goals-obtain accurate luminosity functions to compare with their Galactic counterparts, determine metallicities from the slope of the giant branch, identify long-period variables, and estimate ages from the AGB tip luminosity-we must be able to disentangle the true properties of the population from the observational effects associated with measurements made in very crowded fields. We thus use three different techniques to analyze the effects of crowding on our data, including the insertion of artificial stars (traditional completeness tests) and the creation of completely artificial clusters. These computer simulations are used to derive threshold- and critical-blending radii for each cluster, which determine how close to the cluster center reliable photometry can be achieved. The simulations also allow us to quantify and correct for the effects of blending on the slope and width of the RGB at different surface brightness levels. We then use these results to estimate the limits blending will place on future space-based observations. Based on observations with the NASA/ESA Hubble Space Telescope obtained at the Space Telescope Science

Observability and Estimation of Distributed Space Systems via Local Information-Exchange Networks

Science.gov (United States)

Fathpour, Nanaz; Hadaegh, Fred Y.; Mesbahi, Mehran; Rahmani, Amirreza

2011-01-01

Spacecraft formation flying involves the coordination of states among multiple spacecraft through relative sensing, inter-spacecraft communication, and control. Most existing formation-flying estimation algorithms can only be supported via highly centralized, all-to-all, static relative sensing. New algorithms are proposed that are scalable, modular, and robust to variations in the topology and link characteristics of the formation exchange network. These distributed algorithms rely on a local information exchange network, relaxing the assumptions on existing algorithms. Distributed space systems rely on a signal transmission network among multiple spacecraft for their operation. Control and coordination among multiple spacecraft in a formation is facilitated via a network of relative sensing and interspacecraft communications. Guidance, navigation, and control rely on the sensing network. This network becomes more complex the more spacecraft are added, or as mission requirements become more complex. The observability of a formation state was observed by a set of local observations from a particular node in the formation. Formation observability can be parameterized in terms of the matrices appearing in the formation dynamics and observation matrices. An agreement protocol was used as a mechanism for observing formation states from local measurements. An agreement protocol is essentially an unforced dynamic system whose trajectory is governed by the interconnection geometry and initial condition of each node, with a goal of reaching a common value of interest. The observability of the interconnected system depends on the geometry of the network, as well as the position of the observer relative to the topology. For the first time, critical GN&C (guidance, navigation, and control estimation) subsystems are synthesized by bringing the contribution of the spacecraft information-exchange network to the forefront of algorithmic analysis and design. The result is a

Momentum-space resummation for transverse observables and the Higgs p ⊥ at N3LL+NNLO

Science.gov (United States)

Bizoń, Wojciech; Monni, Pier Francesco; Re, Emanuele; Rottoli, Luca; Torrielli, Paolo

2018-02-01

We present an approach to the momentum-space resummation of global, recursively infrared and collinear safe observables that can vanish away from the Sudakov region. We focus on the hadro-production of a generic colour singlet, and we consider the class of observables that depend only upon the total transverse momentum of the radiation, prime examples being the transverse momentum of the singlet, and ϕ ∗ in Drell-Yan pair production. We derive a resummation formula valid up to next-to-next-to-next-to-leading-logarithmic accuracy for the considered class of observables. We use this result to compute state-of-the-art predictions for the Higgs-boson transverse-momentum spectrum at the LHC at next-to-next-to-next-to-leading-logarithmic accuracy matched to fixed next-to-next-to-leading order. Our resummation formula reduces exactly to the customary resummation performed in impact-parameter space in the known cases, and it also predicts the correct power-behaved scaling of the cross section in the limit of small value of the observable. We show how this formalism is efficiently implemented by means of Monte Carlo techniques in a fully exclusive generator that allows one to apply arbitrary cuts on the Born variables for any colour singlet, as well as to automatically match the resummed results to fixed-order calculations.

Real-space observation of nanojet-induced modes in a chain of microspheres

International Nuclear Information System (INIS)

Liu, Cheng-Yang; Wang, Po-Kai

2014-01-01

The three-dimensional real-space observation of photonic nanojet-induced modes in a chain of microspheres with different diameters is reported. The optical transmission properties of a chain of microspheres are studied by using high resolution finite-difference time-domain calculation. The photonic nanojet-induced modes in different chains of microspheres are measured by using a scanning optical microscope system with an optical-fiber probe. We observe the photonic nanojet-induced modes from optical microscope images for chains of 3 μm, 5 μm, and 8 μm microspheres deposited on a patterned silicon substrate. The incident beam can be periodically reproduced in chains of dielectric microspheres giving rise to lossless periodically optical focusing with period of two diameters. Detailed theoretical and experimental data on the transmission, scattering loss, and field-of-view are presented. This waveguide technique can be used in biomedical microscopy, ultra-precise laser process, microfluidics, and nanophotonic circuits.

Real-space observation of nanojet-induced modes in a chain of microspheres

Energy Technology Data Exchange (ETDEWEB)

Liu, Cheng-Yang, E-mail: cyliu@mail.tku.edu.tw; Wang, Po-Kai

2014-04-01

The three-dimensional real-space observation of photonic nanojet-induced modes in a chain of microspheres with different diameters is reported. The optical transmission properties of a chain of microspheres are studied by using high resolution finite-difference time-domain calculation. The photonic nanojet-induced modes in different chains of microspheres are measured by using a scanning optical microscope system with an optical-fiber probe. We observe the photonic nanojet-induced modes from optical microscope images for chains of 3 μm, 5 μm, and 8 μm microspheres deposited on a patterned silicon substrate. The incident beam can be periodically reproduced in chains of dielectric microspheres giving rise to lossless periodically optical focusing with period of two diameters. Detailed theoretical and experimental data on the transmission, scattering loss, and field-of-view are presented. This waveguide technique can be used in biomedical microscopy, ultra-precise laser process, microfluidics, and nanophotonic circuits.

Comparing Young and Elderly Serial Reaction Time Task Performance on Repeated and Random Conditions

Directory of Open Access Journals (Sweden)

Fatemeh Ehsani

2012-07-01

Full Text Available Objectives: Acquisition motor skill training in elderly is at great importance. The main purpose of this study was to compare young and elderly performance in serial reaction time task on different repeated and random conditions. Methods & Materials: A serial reaction time task by using software was applied for studying motor learning in 30 young and 30 elderly. Each group divided randomly implicitly and explicitly into subgroups. A task 4 squares with different colors appeared on the monitor and subjects were asked to press its defined key immediately after observing it. Subjects practiced 8 motor blocks (4 repeated blocks, then 2 random blocks and 2 repeated blocks. Block time that was dependent variable measured and Independent-samples t- test with repeated ANOVA measures were used in this test. Results: young groups performed both repeated and random sequences significantly faster than elderly (P0.05. Explicit older subgroup performed 7,8 blocks slower than 6 block with a significant difference (P<0.05. Conclusion: Young adults discriminate high level performance than elderly in both repeated and random practice. Elderly performed random practice better than repeated practice.

Repeated DNA sequences in fungi

Energy Technology Data Exchange (ETDEWEB)

Dutta, S K

1974-11-01

Several fungal species, representatives of all broad groups like basidiomycetes, ascomycetes and phycomycetes, were examined for the nature of repeated DNA sequences by DNA:DNA reassociation studies using hydroxyapatite chromatography. All of the fungal species tested contained 10 to 20 percent repeated DNA sequences. There are approximately 100 to 110 copies of repeated DNA sequences of approximately 4 x 10/sup 7/ daltons piece size of each. Repeated DNA sequence homoduplexes showed on average 5/sup 0/C difference of T/sub e/50 (temperature at which 50 percent duplexes dissociate) values from the corresponding homoduplexes of unfractionated whole DNA. It is suggested that a part of repetitive sequences in fungi constitutes mitochondrial DNA and a part of it constitutes nuclear DNA. (auth)

Topological characteristics of helical repeat proteins

NARCIS (Netherlands)

Groves, M R; Barford, D

The recent elucidation of protein structures based upon repeating amino acid motifs, including the armadillo motif, the HEAT motif and tetratricopeptide repeats, reveals that they belong to the class of helical repeat proteins. These proteins share the common property of being assembled from tandem

Ground Radar Polarimetric Observations of High-Frequency Earth-Space Communication Links

Science.gov (United States)

Bolen, Steve; Chandrasekar, V.; Benjamin, Andrew

2002-01-01

Strategic roadmaps for NASA's Human Exploration and Development of Space (REDS) enterprise support near-term high-frequency communication systems that provide moderate to high data rates with dependable service. Near-earth and human planetary exploration will baseline Ka-Band, but may ultimately require the use of even higher frequencies. Increased commercial demand on low-frequency earth-space bands has also led to increased interest in the use of higher frequencies in regions like K u - and K,- band. Data is taken from the Tropical Rainfall Measuring Mission (TRMM) Precipitation Radar (PR), which operates at 13.8 GHz, and the true radar reflectivity profile is determined along the PR beam via low-frequency ground based polarimetric observations. The specific differential phase (Kdp) is measured along the beam and a theoretical model is used to determine the expected specific attenuation (k). This technique, called the k-Kdp method, uses a Fuzzy-Logic model to determine the hydrometeor type along the PR beam from which the appropriate k-Kdp relationship is used to determine k and, ultimately, the total path-integrated attenuation (PIA) on PR measurements. Measurements from PR and the NCAR S-POL radar were made during the TEFLUN-B experiment that took place near Melbourne, FL in 1998, and the TRMM-LBA campaign near Ji-Parana, Brazil in 1999.

Quantum teleportation and entanglement distribution over 100-kilometre free-space channels.

Science.gov (United States)

Yin, Juan; Ren, Ji-Gang; Lu, He; Cao, Yuan; Yong, Hai-Lin; Wu, Yu-Ping; Liu, Chang; Liao, Sheng-Kai; Zhou, Fei; Jiang, Yan; Cai, Xin-Dong; Xu, Ping; Pan, Ge-Sheng; Jia, Jian-Jun; Huang, Yong-Mei; Yin, Hao; Wang, Jian-Yu; Chen, Yu-Ao; Peng, Cheng-Zhi; Pan, Jian-Wei

2012-08-09

Transferring an unknown quantum state over arbitrary distances is essential for large-scale quantum communication and distributed quantum networks. It can be achieved with the help of long-distance quantum teleportation and entanglement distribution. The latter is also important for fundamental tests of the laws of quantum mechanics. Although quantum teleportation and entanglement distribution over moderate distances have been realized using optical fibre links, the huge photon loss and decoherence in fibres necessitate the use of quantum repeaters for larger distances. However, the practical realization of quantum repeaters remains experimentally challenging. Free-space channels, first used for quantum key distribution, offer a more promising approach because photon loss and decoherence are almost negligible in the atmosphere. Furthermore, by using satellites, ultra-long-distance quantum communication and tests of quantum foundations could be achieved on a global scale. Previous experiments have achieved free-space distribution of entangled photon pairs over distances of 600 metres (ref. 14) and 13 kilometres (ref. 15), and transfer of triggered single photons over a 144-kilometre one-link free-space channel. Most recently, following a modified scheme, free-space quantum teleportation over 16 kilometres was demonstrated with a single pair of entangled photons. Here we report quantum teleportation of independent qubits over a 97-kilometre one-link free-space channel with multi-photon entanglement. An average fidelity of 80.4 ± 0.9 per cent is achieved for six distinct states. Furthermore, we demonstrate entanglement distribution over a two-link channel, in which the entangled photons are separated by 101.8 kilometres. Violation of the Clauser-Horne-Shimony-Holt inequality is observed without the locality loophole. Besides being of fundamental interest, our results represent an important step towards a global quantum network. Moreover, the high

Repeat immigration: A previously unobserved source of heterogeneity?

Science.gov (United States)

Aradhya, Siddartha; Scott, Kirk; Smith, Christopher D

2017-07-01

Register data allow for nuanced analyses of heterogeneities between sub-groups which are not observable in other data sources. One heterogeneity for which register data is particularly useful is in identifying unique migration histories of immigrant populations, a group of interest across disciplines. Years since migration is a commonly used measure of integration in studies seeking to understand the outcomes of immigrants. This study constructs detailed migration histories to test whether misclassified migrations may mask important heterogeneities. In doing so, we identify a previously understudied group of migrants called repeat immigrants, and show that they differ systematically from permanent immigrants. In addition, we quantify the degree to which migration information is misreported in the registers. The analysis is carried out in two steps. First, we estimate income trajectories for repeat immigrants and permanent immigrants to understand the degree to which they differ. Second, we test data validity by cross-referencing migration information with changes in income to determine whether there are inconsistencies indicating misreporting. From the first part of the analysis, the results indicate that repeat immigrants systematically differ from permanent immigrants in terms of income trajectories. Furthermore, income trajectories differ based on the way in which years since migration is calculated. The second part of the analysis suggests that misreported migration events, while present, are negligible. Repeat immigrants differ in terms of income trajectories, and may differ in terms of other outcomes as well. Furthermore, this study underlines that Swedish registers provide a reliable data source to analyze groups which are unidentifiable in other data sources.

UK 2009-2010 repeat station report

Directory of Open Access Journals (Sweden)

Thomas J.G. Shanahan

2013-03-01

Full Text Available The British Geological Survey is responsible for conducting the UK geomagnetic repeat station programme. Measurements made at the UK repeat station sites are used in conjunction with the three UK magnetic observatories: Hartland, Eskdalemuir and Lerwick, to produce a regional model of the local field each year. The UK network of repeat stations comprises 41 stations which are occupied at approximately 3-4 year intervals. Practices for conducting repeat station measurements continue to evolve as advances are made in survey instrumentation and as the usage of the data continues to change. Here, a summary of the 2009 and 2010 UK repeat station surveys is presented, highlighting the measurement process and techniques, density of network, reduction process and recent results.

Performance of thallium bromide semiconductor detectors produced by repeated Bridgman method

International Nuclear Information System (INIS)

Santos, Robinson Alves dos; Costa, Fabio Eduardo da; Martins, Joao Francisco Trencher; Hamada, Margarida M.

2009-01-01

TlBr crystals have been grown by the Repeated Bridgman method from commercial TlBr materials and characterized to be used as radiation detectors. We have shown that the Repeated Bridgman is effective to reduce the concentration of impurities in TlBr. It was observed that detectors fabricated from higher purity crystal exhibit significant improvement in performance compared to those produced from low purity crystals. However, problems still exist in TlBr detectors, due to the low charge carrier collection efficiency, which is probably caused by additional impurities or defects incorporated during crystal growth and detector fabrication processes. (author)

Hungarian repeat station survey, 2010

Directory of Open Access Journals (Sweden)

Péter Kovács

2013-03-01

Full Text Available The last Hungarian repeat station survey was completed between October 2010 and February 2011. Declination, inclination and the total field were observed using one-axial DMI fluxgate magnetometer mounted on Zeiss20A theodolite and GSM 19 Overhauser magnetometer. The magnetic elements of the sites were reduced to the epoch of 2010.5 on the basis of the continuous recordings of Tihany Geophysical Observatory. In stations located far from the reference observatory, the observations were carried out in the morning and afternoon in order to decrease the effect of the distant temporal correction. To further increase the accuracy, on-site dIdD variometer has also been installed near the Aggtelek station, in the Baradla cave, during the survey of the easternmost sites. The paper presents the technical details and the results of our last campaign. The improvement of the accuracy of the temporal reduction by the use of the local variometer is also reported.

The Probabilistic Structure of Quantum Theory as Originating from Optimal Observation in the Face of the Observer's Lack of Knowledge of his Own State

Science.gov (United States)

Aerts, Sven

2014-03-01

One of the problems facing any attempt to understand quantum theory is that the theory does not seem to offer an explanation of the way the probabilities arise. Moreover, it is a commonly held view that no such explanation is compatible with the mathematical structure of quantum theory, i.e. that the theory is inherently indeterministic, simply because nature is like that. We propose an abstract formalisation of the observation of a system in which the interaction between the system and the observer deterministically produces one of n possible outcomes. If the observer consistently manages to realize the outcome which maximizes the likelihood ratio that the outcome was inferred from the state of the system under study (and not from his own state), he will be called optimal. The probability for a repeated measurement on an ensemble of identical system states, is then derived as a measure over observer states. If the state of the system is a statistical mixture, the optimal observer produces an unbiased estimate of the components of the mixture. In case the state space is a complex Hilbert space, the resulting probability is equal to the one given by the Born rule. The proposal offers a concise interpretation for the meaning of the occurrence of a specific outcome as the unique outcome that, relative to the state of the system, is least dependent on the state of the observer. We note that a similar paradigm is used in the literature of perception to explain optical illusions in human visual perception. We argue that the result strengthens Helmholtz's view that all observation, is in fact a form a inference.

Reject/repeat analysis and the effect prior film viewing has on a department's reject/repeat rate

International Nuclear Information System (INIS)

Clark, P.A.; Hogg, P.

2003-01-01

Purpose: Achieving cost-effectiveness within the NHS is an old initiative but one that has again been highlighted by recent government policies (The New NHS-Modern and Dependable, Stationary Office, London, 1997). It has been reiterated that it is the responsibility of individual Trusts to devise means to provide such a service. Reject/repeat analyses have long been the primary tool used to assess the cost-effectiveness of radiography departments (Quality Assurance in Diagnostic Radiology, WHO, Geneva, 1982). This research paper examines an in-house initiative (viewing patients' previous films) commonly employed in other Health Trusts in order to reduce departmental repeat/reject rates. Method: Three hundred orthopaedic patients with hip, knee and ankle prostheses were included in a reject/repeat analysis. The aim was to investigate whether or not viewing patient's previous relevant radiographs would be advantageous to the practicing radiographer. This was done through an audit cycle consisting of two audit periods each lasting for 3 months. The primary audit period recorded the baseline repeat/reject rate, with the secondary audit period recording the repeat/reject rate under an experimental condition of viewing the relevant radiographs. Results: The baseline audit revealed repeat rates of 33% in orthopaedic patients with hip, knee and ankle prostheses. The availability of prior film viewing to the radiographer reduced this repeat rate to 10.6%. Conclusion: Prior film viewing dramatically reduced the department's repeat/reject rate by 22.4%. This provides scope for significant patient dose reductions as well as reducing departmental film expenses. This is an underestimated initiative and should be used appropriately in routine clinical practice

No impact of repeated extinction exposures on operant responding maintained by different reinforcer rates.

Science.gov (United States)

Bai, John Y H; Podlesnik, Christopher A

2017-05-01

Greater rates of intermittent reinforcement in the presence of discriminative stimuli generally produce greater resistance to extinction, consistent with predictions of behavioral momentum theory. Other studies reveal more rapid extinction with higher rates of reinforcers - the partial reinforcement extinction effect. Further, repeated extinction often produces more rapid decreases in operant responding due to learning a discrimination between training and extinction contingencies. The present study examined extinction repeatedly with training with different rates of intermittent reinforcement in a multiple schedule. We assessed whether repeated extinction would reverse the pattern of greater resistance to extinction with greater reinforcer rates. Counter to this prediction, resistance to extinction was consistently greater across twelve assessments of training followed by six successive sessions of extinction. Moreover, patterns of responding during extinction resembled those observed during satiation tests, which should not alter discrimination processes with repeated testing. These findings join others suggesting operant responding in extinction can be durable across repeated tests. Copyright © 2017 Elsevier B.V. All rights reserved.

Computational study of the human dystrophin repeats: interaction properties and molecular dynamics.

Directory of Open Access Journals (Sweden)

Baptiste Legrand

Full Text Available Dystrophin is a large protein involved in the rare genetic disease Duchenne muscular dystrophy (DMD. It functions as a mechanical linker between the cytoskeleton and the sarcolemma, and is able to resist shear stresses during muscle activity. In all, 75% of the dystrophin molecule consists of a large central rod domain made up of 24 repeat units that share high structural homology with spectrin-like repeats. However, in the absence of any high-resolution structure of these repeats, the molecular basis of dystrophin central domain's functions has not yet been deciphered. In this context, we have performed a computational study of the whole dystrophin central rod domain based on the rational homology modeling of successive and overlapping tandem repeats and the analysis of their surface properties. Each tandem repeat has very specific surface properties that make it unique. However, the repeats share enough electrostatic-surface similarities to be grouped into four separate clusters. Molecular dynamics simulations of four representative tandem repeats reveal specific flexibility or bending properties depending on the repeat sequence. We thus suggest that the dystrophin central rod domain is constituted of seven biologically relevant sub-domains. Our results provide evidence for the role of the dystrophin central rod domain as a scaffold platform with a wide range of surface features and biophysical properties allowing it to interact with its various known partners such as proteins and membrane lipids. This new integrative view is strongly supported by the previous experimental works that investigated the isolated domains and the observed heterogeneity of the severity of dystrophin related pathologies, especially Becker muscular dystrophy.

3D space analysis of dental models

Science.gov (United States)

Chuah, Joon H.; Ong, Sim Heng; Kondo, Toshiaki; Foong, Kelvin W. C.; Yong, Than F.

2001-05-01

Space analysis is an important procedure by orthodontists to determine the amount of space available and required for teeth alignment during treatment planning. Traditional manual methods of space analysis are tedious and often inaccurate. Computer-based space analysis methods that work on 2D images have been reported. However, as the space problems in the dental arch exist in all three planes of space, a full 3D analysis of the problems is necessary. This paper describes a visualization and measurement system that analyses 3D images of dental plaster models. Algorithms were developed to determine dental arches. The system is able to record the depths of the Curve of Spee, and quantify space liabilities arising from a non-planar Curve of Spee, malalignment and overjet. Furthermore, the difference between total arch space available and the space required to arrange the teeth in ideal occlusion can be accurately computed. The system for 3D space analysis of the dental arch is an accurate, comprehensive, rapid and repeatable method of space analysis to facilitate proper orthodontic diagnosis and treatment planning.

Polymorphic repeat in AIB1 does not alter breast cancer risk

International Nuclear Information System (INIS)

Haiman, Christopher A; Hankinson, Susan E; Spiegelman, Donna; Colditz, Graham A; Willett, Walter C; Speizer, Frank E; Brown, Myles; Hunter, David J

2000-01-01

We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no association between AIB1 genotype and breast cancer incidence, or specific tumor characteristics. These findings suggest that AIB1 repeat genotype does not influence postmenopausal breast cancer risk among Caucasian women in the general population. A causal association between endogenous and exogenous estrogens and breast cancer has been established. Steroid hormones regulate the expression of proteins that are involved in breast cell proliferation and development after binding to their respective steroid hormone receptors. Coactivator and corepressor proteins have recently been identified that interact with steroid hormone receptors and modulate transcriptional activation [1]. AIB1 (amplified in breast 1) is a member of the steroid receptor coactivator (SRC) family that interacts with estrogen receptor (ER)α in a ligand-dependent manner, and increases estrogen-dependent transcription [2]. Amplification and overexpression of AIB1 has been observed in breast and ovarian cancer cell lines and in breast tumors [2,3]. A polymorphic stretch of glutamine amino acids, with unknown biologic function, has recently been described in the carboxyl-terminal region of AIB1 [4]. Among women with germline BRCA1 mutations, significant positive associations were observed between AIB1 alleles with 26 or fewer glutamine repeats and breast cancer risk [5] To establish whether AIB1 repeat alleles are associated with breast cancer risk and specific tumor characteristics among Caucasian women. We evaluated associations prospectively between AIB1 alleles and breast cancer risk in the Nurses' Health Study using a nested case-control design. The Nurses' Health Study was initiated in 1976, when 121 700 US-registered nurses between the ages of 30 and 55 years returned an

Observational Model for Precision Astrometry with the Space Interferometry Mission

National Research Council Canada - National Science Library

Turyshev, Slava G; Milman, Mark H

2000-01-01

The Space Interferometry Mission (SIM) is a space-based 10-m baseline Michelson optical interferometer operating in the visible waveband that is designed to achieve astrometric accuracy in the single digits of the microarcsecond domain...

Research on Optimal Observation Scale for Damaged Buildings after Earthquake Based on Optimal Feature Space

Science.gov (United States)

Chen, J.; Chen, W.; Dou, A.; Li, W.; Sun, Y.

2018-04-01

A new information extraction method of damaged buildings rooted in optimal feature space is put forward on the basis of the traditional object-oriented method. In this new method, ESP (estimate of scale parameter) tool is used to optimize the segmentation of image. Then the distance matrix and minimum separation distance of all kinds of surface features are calculated through sample selection to find the optimal feature space, which is finally applied to extract the image of damaged buildings after earthquake. The overall extraction accuracy reaches 83.1 %, the kappa coefficient 0.813. The new information extraction method greatly improves the extraction accuracy and efficiency, compared with the traditional object-oriented method, and owns a good promotional value in the information extraction of damaged buildings. In addition, the new method can be used for the information extraction of different-resolution images of damaged buildings after earthquake, then to seek the optimal observation scale of damaged buildings through accuracy evaluation. It is supposed that the optimal observation scale of damaged buildings is between 1 m and 1.2 m, which provides a reference for future information extraction of damaged buildings.

Dispersion Measure Variation of Repeating Fast Radio Burst Sources

Energy Technology Data Exchange (ETDEWEB)

Yang, Yuan-Pei; Zhang, Bing, E-mail: yypspore@gmail.com, E-mail: zhang@physics.unlv.edu [Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China)

2017-09-20

The repeating fast radio burst (FRB) 121102 was recently localized in a dwarf galaxy at a cosmological distance. The dispersion measure (DM) derived for each burst from FRB 121102 so far has not shown significant evolution, even though an apparent increase was recently seen with newly detected VLA bursts. It is expected that more repeating FRB sources may be detected in the future. In this work, we investigate a list of possible astrophysical processes that might cause DM variation of a particular FRB source. The processes include (1) cosmological scale effects such as Hubble expansion and large-scale structure fluctuations; (2) FRB local effects such as gas density fluctuation, expansion of a supernova remnant (SNR), a pulsar wind nebula, and an H ii region; and (3) the propagation effect due to plasma lensing. We find that the DM variations contributed by the large-scale structure are extremely small, and any observable DM variation is likely caused by the plasma local to the FRB source. In addition to mechanisms that decrease DM over time, we suggest that an FRB source in an expanding SNR around a nearly neutral ambient medium during the deceleration (Sedov–Taylor and snowplow) phases or in a growing H ii region can increase DM. Some effects (e.g., an FRB source moving in an H ii region or plasma lensing) can produce either positive or negative DM variations. Future observations of DM variations of FRB 121102 and other repeating FRB sources can provide important clues regarding the physical origin of these sources.

Dispersion Measure Variation of Repeating Fast Radio Burst Sources

International Nuclear Information System (INIS)

Yang, Yuan-Pei; Zhang, Bing

2017-01-01

The repeating fast radio burst (FRB) 121102 was recently localized in a dwarf galaxy at a cosmological distance. The dispersion measure (DM) derived for each burst from FRB 121102 so far has not shown significant evolution, even though an apparent increase was recently seen with newly detected VLA bursts. It is expected that more repeating FRB sources may be detected in the future. In this work, we investigate a list of possible astrophysical processes that might cause DM variation of a particular FRB source. The processes include (1) cosmological scale effects such as Hubble expansion and large-scale structure fluctuations; (2) FRB local effects such as gas density fluctuation, expansion of a supernova remnant (SNR), a pulsar wind nebula, and an H ii region; and (3) the propagation effect due to plasma lensing. We find that the DM variations contributed by the large-scale structure are extremely small, and any observable DM variation is likely caused by the plasma local to the FRB source. In addition to mechanisms that decrease DM over time, we suggest that an FRB source in an expanding SNR around a nearly neutral ambient medium during the deceleration (Sedov–Taylor and snowplow) phases or in a growing H ii region can increase DM. Some effects (e.g., an FRB source moving in an H ii region or plasma lensing) can produce either positive or negative DM variations. Future observations of DM variations of FRB 121102 and other repeating FRB sources can provide important clues regarding the physical origin of these sources.

Repeated cognitive stimulation alleviates memory impairments in an Alzheimer's disease mouse model.

Science.gov (United States)

Martinez-Coria, Hilda; Yeung, Stephen T; Ager, Rahasson R; Rodriguez-Ortiz, Carlos J; Baglietto-Vargas, David; LaFerla, Frank M

2015-08-01

Alzheimer's disease is a neurodegenerative disease associated with progressive memory and cognitive decline. Previous studies have identified the benefits of cognitive enrichment on reducing disease pathology. Additionally, epidemiological and clinical data suggest that repeated exercise, and cognitive and social enrichment, can improve and/or delay the cognitive deficiencies associated with aging and neurodegenerative diseases. In the present study, 3xTg-AD mice were exposed to a rigorous training routine beginning at 3 months of age, which consisted of repeated training in the Morris water maze spatial recognition task every 3 months, ending at 18 months of age. At the conclusion of the final Morris water maze training session, animals subsequently underwent testing in another hippocampus-dependent spatial task, the Barnes maze task, and on the more cortical-dependent novel object recognition memory task. Our data show that periodic cognitive enrichment throughout aging, via multiple learning episodes in the Morris water maze task, can improve the memory performance of aged 3xTg-AD mice in a separate spatial recognition task, and in a preference memory task, when compared to naïve aged matched 3xTg-AD mice. Furthermore, we observed that the cognitive enrichment properties of Morris water maze exposer, was detectable in repeatedly trained animals as early as 6 months of age. These findings suggest early repeated cognitive enrichment can mitigate the diverse cognitive deficits observed in Alzheimer's disease. Published by Elsevier Inc.

The energy landscapes of repeat-containing proteins: topology, cooperativity, and the folding funnels of one-dimensional architectures.

Directory of Open Access Journals (Sweden)

Diego U Ferreiro

2008-05-01

Full Text Available Repeat-proteins are made up of near repetitions of 20- to 40-amino acid stretches. These polypeptides usually fold up into non-globular, elongated architectures that are stabilized by the interactions within each repeat and those between adjacent repeats, but that lack contacts between residues distant in sequence. The inherent symmetries both in primary sequence and three-dimensional structure are reflected in a folding landscape that may be analyzed as a quasi-one-dimensional problem. We present a general description of repeat-protein energy landscapes based on a formal Ising-like treatment of the elementary interaction energetics in and between foldons, whose collective ensemble are treated as spin variables. The overall folding properties of a complete "domain" (the stability and cooperativity of the repeating array can be derived from this microscopic description. The one-dimensional nature of the model implies there are simple relations for the experimental observables: folding free-energy (DeltaG(water and the cooperativity of denaturation (m-value, which do not ordinarily apply for globular proteins. We show how the parameters for the "coarse-grained" description in terms of foldon spin variables can be extracted from more detailed folding simulations on perfectly funneled landscapes. To illustrate the ideas, we present a case-study of a family of tetratricopeptide (TPR repeat proteins and quantitatively relate the results to the experimentally observed folding transitions. Based on the dramatic effect that single point mutations exert on the experimentally observed folding behavior, we speculate that natural repeat proteins are "poised" at particular ratios of inter- and intra-element interaction energetics that allow them to readily undergo structural transitions in physiologically relevant conditions, which may be intrinsically related to their biological functions.

Poster: Observing change in crowded data sets in 3D space - Visualizing gene expression in human tissues

KAUST Repository

Rogowski, Marcin

2013-03-01

We have been confronted with a real-world problem of visualizing and observing change of gene expression between different human tissues. In this paper, we are presenting a universal representation space based on two-dimensional gel electrophoresis as opposed to force-directed layouts encountered most often in similar problems. We are discussing the methods we devised to make observing change more convenient in a 3D virtual reality environment. © 2013 IEEE.

Development of repeated sprint ability in talented youth basketball players

NARCIS (Netherlands)

te Wierike, Simon; Lemmink, Koen; de Jong, M.C.; Tromp, E.J.; Vuijk, P.J.; Malina, R.M.; Elferink-Gemser, Marije; Visscher, Chris

2013-01-01

Factors affecting repeated sprint ability (RSA) were evaluated in a mixed-longitudinal sample of 48 elite basketball players 14 to 19 years of age (16.1±1.7 years). Players were observed on six occasions during the 2008-2009 and 2009-2010 seasons. Three basketball-specific field tests were

Development of repeated sprint ability in talented youth basketball players.

NARCIS (Netherlands)

Koen A.P.M. Lemmink; P.J. Vuijk; S.C. te Wierike; C. Visscher; M.T. Elferink-Gemser; M.C. de Jong; R.M. Malina; E.J. Tromp

2013-01-01

Factors affecting repeated sprint ability (RSA) were evaluated in a mixed-longitudinal sample of 48 elite basketball players 14 to 19 years of age (16.1±1.7 years). Players were observed on six occasions during the 2008-2009 and 2009-2010 seasons. Three basketball-specific field tests were

Somatic mosaicism of androgen receptor CAG repeats in colorectal carcinoma epithelial cells from men.

Science.gov (United States)

Di Fabio, Francesco; Alvarado, Carlos; Gologan, Adrian; Youssef, Emad; Voda, Linda; Mitmaker, Elliot; Beitel, Lenore K; Gordon, Philip H; Trifiro, Mark

2009-06-01

The X-linked human androgen receptor gene (AR) contains an exonic polymorphic trinucleotide CAG. The length of this encoded CAG tract inversely affects AR transcriptional activity. Colorectal carcinoma is known to express the androgen receptor, but data on somatic CAG repeat lengths variations in malignant and normal epithelial cells are still sporadic. Using laser capture microdissection (LCM), epithelial cells from colorectal carcinoma and normal-appearing mucosa were collected from the fresh tissue of eight consecutive male patients undergoing surgery (mean age, 70 y; range, 54-82). DNA isolated from each LCM sample underwent subsequent PCR and DNA sequencing to precisely determine AR CAG repeat lengths and the presence of microsatellite instability (MSI). Different AR CAG repeat lengths were observed in colorectal carcinoma (ranging from 0 to 36 CAG repeats), mainly in the form of multiple shorter repeat lengths. This genetic heterogeneity (somatic mosaicism) was also found in normal-appearing colorectal mucosa. Half of the carcinoma cases examined tended to have a higher number of AR CAG repeat lengths with a wider range of repeat size variation compared to normal mucosa. MSI carcinomas tended to have longer median AR CAG repeat lengths (n = 17) compared to microsatellite stable carcinomas (n = 14), although the difference was not significant (P = 0.31, Mann-Whitney test). Multiple unique somatic mutations of the AR CAG repeats occur in colorectal mucosa and in carcinoma, predominantly resulting in shorter alleles. Colorectal epithelial cells carrying AR alleles with shorter CAG repeat lengths may be more androgen-sensitive and therefore have a growth advantage.

Repeating Marx

DEFF Research Database (Denmark)

Fuchs, Christian; Monticelli, Lara

2018-01-01

This introduction sets out the context of the special issue “Karl Marx @ 200: Debating Capitalism & Perspectives for the Future of Radical Theory”, which was published on the occasion of Marx’s bicentenary on 5 May 2018. First, we give a brief overview of contemporary capitalism’s development...... and its crises. Second, we argue that it is important to repeat Marx today. Third, we reflect on lessons learned from 200 years of struggles for alternatives to capitalism. Fourth, we give an overview of the contributions in this special issue. Taken together, the contributions in this special issue show...... that Marx’s theory and politics remain key inspirations for understanding exploitation and domination in 21st-century society and for struggles that aim to overcome these phenomena and establishing a just and fair society. We need to repeat Marx today....

The spacing between adjacent binding sites in the family of repeats affects the functions of Epstein-Barr nuclear antigen 1 in transcription activation and stable plasmid maintenance.

Science.gov (United States)

Hebner, Christy; Lasanen, Julie; Battle, Scott; Aiyar, Ashok

2003-07-05

Epstein-Barr virus (EBV) and the closely related Herpesvirus papio (HVP) are stably replicated as episomes in proliferating latently infected cells. Maintenance and partitioning of these viral plasmids requires a viral sequence in cis, termed the family of repeats (FR), that is bound by a viral protein, Epstein-Barr nuclear antigen 1 (EBNA1). Upon binding FR, EBNA1 maintains viral genomes in proliferating cells and activates transcription from viral promoters required for immortalization. FR from either virus encodes multiple binding sites for the viral maintenance protein, EBNA1, with the FR from the prototypic B95-8 strain of EBV containing 20 binding sites, and FR from HVP containing 8 binding sites. In addition to differences in the number of EBNA1-binding sites, adjacent binding sites in the EBV FR are typically separated by 14 base pairs (bp), but are separated by 10 bp in HVP. We tested whether the number of binding sites, as well as the distance between adjacent binding sites, affects the function of EBNA1 in transcription activation or plasmid maintenance. Our results indicate that EBNA1 activates transcription more efficiently when adjacent binding sites are separated by 10 bp, the spacing observed in HVP. In contrast, using two separate assays, we demonstrate that plasmid maintenance is greatly augmented when adjacent EBNA1-binding sites are separated by 14 bp, and therefore, presumably lie on the same face of the DNA double helix. These results provide indication that the functions of EBNA1 in transcription activation and plasmid maintenance are separable.

The spacing between adjacent binding sites in the family of repeats affects the functions of Epstein-Barr nuclear antigen 1 in transcription activation and stable plasmid maintenance

International Nuclear Information System (INIS)

Hebner, Christy; Lasanen, Julie; Battle, Scott; Aiyar, Ashok

2003-01-01

Epstein-Barr virus (EBV) and the closely related Herpesvirus papio (HVP) are stably replicated as episomes in proliferating latently infected cells. Maintenance and partitioning of these viral plasmids requires a viral sequence in cis, termed the family of repeats (FR), that is bound by a viral protein, Epstein-Barr nuclear antigen 1 (EBNA1). Upon binding FR, EBNA1 maintains viral genomes in proliferating cells and activates transcription from viral promoters required for immortalization. FR from either virus encodes multiple binding sites for the viral maintenance protein, EBNA1, with the FR from the prototypic B95-8 strain of EBV containing 20 binding sites, and FR from HVP containing 8 binding sites. In addition to differences in the number of EBNA1-binding sites, adjacent binding sites in the EBV FR are typically separated by 14 base pairs (bp), but are separated by 10 bp in HVP. We tested whether the number of binding sites, as well as the distance between adjacent binding sites, affects the function of EBNA1 in transcription activation or plasmid maintenance. Our results indicate that EBNA1 activates transcription more efficiently when adjacent binding sites are separated by 10 bp, the spacing observed in HVP. In contrast, using two separate assays, we demonstrate that plasmid maintenance is greatly augmented when adjacent EBNA1-binding sites are separated by 14 bp, and therefore, presumably lie on the same face of the DNA double helix. These results provide indication that the functions of EBNA1 in transcription activation and plasmid maintenance are separable

CRISPRstrand: predicting repeat orientations to determine the crRNA-encoding strand at CRISPR loci

DEFF Research Database (Denmark)

Alkhnbashi, Omer S.; Costa, Fabrizio; Shah, Shiraz Ali

2014-01-01

Motivation: The discovery of CRISPR-Cas systems almost 20 years ago rapidly changed our perception of the bacterial and archaeal immune systems. CRISPR loci consist of several repetitive DNA sequences called repeats, inter-spaced by stretches of variable length sequences called spacers. This CRISPR...... array is transcribed and processed into multiple mature RNA species (crRNAs). A single crRNA is integrated into an interference complex, together with CRISPR-associated (Cas) proteins, to bind and degrade invading nucleic acids. Although existing bioinformatics tools can recognize CRISPR loci...... by their characteristic repeat-spacer architecture, they generally output CRISPR arrays of ambiguous orientation and thus do not determine the strand from which crRNAs are processed. Knowledge of the correct orientation is crucial for many tasks, including the classification of CRISPR conservation, the detection...

C9orf72 hexanucleotide repeat expansions in Chinese sporadic amyotrophic lateral sclerosis.

Science.gov (United States)

He, Ji; Tang, Lu; Benyamin, Beben; Shah, Sonia; Hemani, Gib; Liu, Rong; Ye, Shan; Liu, Xiaolu; Ma, Yan; Zhang, Huagang; Cremin, Katie; Leo, Paul; Wray, Naomi R; Visscher, Peter M; Xu, Huji; Brown, Matthew A; Bartlett, Perry F; Mangelsdorf, Marie; Fan, Dongsheng

2015-09-01

A hexanucleotide repeat expansion (HRE) in the C9orf72 gene has been identified as the most common mutation in amyotrophic lateral sclerosis (ALS) among Caucasian populations. We sought to comprehensively evaluate genetic and epigenetic variants of C9orf72 and the contribution of the HRE in Chinese ALS cases. We performed fragment-length and repeat-primed polymerase chain reaction to determine GGGGCC copy number and expansion within the C9orf72 gene in 1092 sporadic ALS (sALS) and 1062 controls from China. We performed haplotype analysis of 23 single-nucleotide polymorphisms within and surrounding C9orf72. The C9orf72 HRE was found in 3 sALS patients (0.3%) but not in control subjects (p = 0.25). For 2 of the cases with the HRE, genotypes of 8 single-nucleotide polymorphisms flanking the HRE were inconsistent with the haplotype reported to be strongly associated with ALS in Caucasian populations. For these 2 individuals, we found hypermethylation of the CpG island upstream of the repeat, an observation not detected in other sALS patients (p HRE were highly associated with repeat lengths >8 repeats implying that both haplotypes may confer instability of repeat length. Copyright © 2015 Elsevier Inc. All rights reserved.

Observations of electron phase-space holes driven during magnetic reconnection in a laboratory plasma

Science.gov (United States)

Fox, W.; Porkolab, M.; Egedal, J.; Katz, N.; Le, A.

2012-03-01

This work presents detailed experimental observations of electron phase-space holes driven during magnetic reconnection events on the Versatile Toroidal Facility. The holes are observed to travel on the order of or faster than the electron thermal speed, and are of large size scale, with diameter of order 60 Debye lengths. In addition, they have 3D spheroidal structure with approximately unity aspect ratio. We estimate the direct anomalous resistivity due to ion interaction with the holes and find it to be too small to affect the reconnection rate; however, the holes may play a role in reining in a tail of accelerated electrons and they indicate the presence of other processes in the reconnection layer, such as electron energization and electron beam formation.

A space-efficient algorithm for local similarities.

Science.gov (United States)

Huang, X Q; Hardison, R C; Miller, W

1990-10-01

Existing dynamic-programming algorithms for identifying similar regions of two sequences require time and space proportional to the product of the sequence lengths. Often this space requirement is more limiting than the time requirement. We describe a dynamic-programming local-similarity algorithm that needs only space proportional to the sum of the sequence lengths. The method can also find repeats within a single long sequence. To illustrate the algorithm's potential, we discuss comparison of a 73,360 nucleotide sequence containing the human beta-like globin gene cluster and a corresponding 44,594 nucleotide sequence for rabbit, a problem well beyond the capabilities of other dynamic-programming software.

Transferring Knowledge from a Bird's-Eye View - Earth Observation and Space Travels in Schools

Science.gov (United States)

Rienow, Andreas; Hodam, Henryk; Menz, Gunter; Voß, Kerstin

2014-05-01

In spring 2014, four commercial cameras will be transported by a Dragon spacecraft to the International Space Station (ISS) and mounted to the ESA Columbus laboratory. The cameras will deliver live earth observation data from different angles. The "Columbus-Eye"* project aims at distributing the video and image data produced by those cameras through a web portal. It should primary serve as learning portal for pupils comprising teaching material around the ISS earth observation imagery. The pupils should be motivated to work with the images in order to learn about curriculum relevant topics of natural sciences. The material will be prepared based on the experiences of the FIS* (German abbreviation for "Remote Sensing in Schools") project and its learning portal. Recognizing that in-depth use of satellite imagery can only be achieved by the means of computer aided learning methods, a sizeable number of e-Learning contents in German and English have been created throughout the last 5 years since FIS' kickoff. The talk presents the educational valorization of remote sensing data as well as their interactive implementation for teachers and pupils in both learning portals. It will be shown which possibilities the topic of remote sensing holds ready for teaching the regular curricula of Geography, Biology, Physics, Math and Informatics. Beside the sequenced implementation into digital and interactive teaching units, examples of a richly illustrated encyclopedia as well as easy-to-use image processing tools are given. The presentation finally addresses the question of how synergies of space travels can be used to enhance the fascination of earth observation imagery in the light of problem-based learning in everyday school lessons.

Low degree Earth's gravity coefficients determined from different space geodetic observations and climate models

Science.gov (United States)

Wińska, Małgorzata; Nastula, Jolanta

2017-04-01

Large scale mass redistribution and its transport within the Earth system causes changes in the Earth's rotation in space, gravity field and Earth's ellipsoid shape. These changes are observed in the ΔC21, ΔS21, and ΔC20 spherical harmonics gravity coefficients, which are proportional to the mass load-induced Earth rotational excitations. In this study, linear trend, decadal, inter-annual, and seasonal variations of low degree spherical harmonics coefficients of Earth's gravity field, determined from different space geodetic techniques, Gravity Recovery and Climate Experiment (GRACE), satellite laser ranging (SLR), Global Navigation Satellite System (GNSS), Earth rotation, and climate models, are examined. In this way, the contribution of each measurement technique to interpreting the low degree surface mass density of the Earth is shown. Especially, we evaluate an usefulness of several climate models from the Coupled Model Intercomparison Project phase 5 (CMIP5) to determine the low degree Earth's gravity coefficients using GRACE satellite observations. To do that, Terrestrial Water Storage (TWS) changes from several CMIP5 climate models are determined and then these simulated data are compared with the GRACE observations. Spherical harmonics ΔC21, ΔS21, and ΔC20 changes are calculated as the sum of atmosphere and ocean mass effect (GAC values) taken from GRACE and a land surface hydrological estimate from the selected CMIP5 climate models. Low degree Stokes coefficients of the surface mass density determined from GRACE, SLR, GNSS, Earth rotation measurements and climate models are compared to each other in order to assess their consistency. The comparison is done by using different types of statistical and signal processing methods.

Electron microscope observations of impact crater debris amongst contaminating particulates on materials surfaces exposed in space in low-Earth orbit

Science.gov (United States)

Murr, L. E.; Rivas, J. M.; Quinones, S.; Niou, C.-S.; Advani, A. H.; Marquez, B.

1993-01-01

Debris particles extracted from a small sampling region on the leading edge of the Long Duration Exposure Facility (LDEF) spacecraft have been examined by analytical transmission electron microscopy and the elemental frequency observed by energy-dispersive X-ray spectrometry and compared with upper atmosphere (Earth) particle elemental frequency and the average elemental compositions of interplanetary dust particles. A much broader elemental distribution was observed for the exposed spacecraft surface debris milieu. Numerous metal microfragment analyses, particularly aluminum and stainless steel, were compared with scanning electron microscope observations-of impact crater features, and the corresponding elemental spectra on selected LDEF aluminium tray clamps and stainless steel bolts. The compositions and melt features for these impact craters and ejecta have been shown to be consistent with microcrystalline debris fragments in the case of aluminum, and these observations suggest an ever changing debris milieu on exposed surfaces for space craft and space system materials.

Space Telescope and Optical Reverberation Mapping Project.I. Ultraviolet Observations of the Seyfert 1 Galaxy NGC 5548 with the Cosmic Origins Spectrograph on Hubble Space Telescope

NARCIS (Netherlands)

De Rosa, G.; Peterson, B.M.; Ely, J.; Kriss, G.A.; Crenshaw, D.M.; Horne, K.; Korista, K.T.; Netzer, H.; Pogge, R.W.; Arévalo, P.; Barth, A.J.; Bentz, M.C.; Brandt, W.N.; Breeveld, A.A.; Brewer, B.J.; Dalla Bontà, E.; De Lorenzo-Cáceres, A.; Denney, K.D.; Dietrich, M.; Edelson, R.; Evans, P.A.; Fausnaugh, M.M.; Gehrels, N.; Gelbord, J.M.; Goad, M.R.; Grier, C.J.; Grupe, D.; Hall, P.B.; Kaastra, J.; Kelly, B.C.; Kennea, J.A.; Kochanek, C.S.; Lira, P.; Mathur, S.; McHardy, I.M.; Nousek, J.A.; Pancoast, A.; Papadakis, I.; Pei, L.; Schimoia, J.S.; Siegel, M.; Starkey, D.; Treu, T.; Uttley, P.; Vaughan, S.; Vestergaard, M.; Villforth, C.; Yan, H.; Young, S.; Zu, Y.

2015-01-01

We describe the first results from a six-month long reverberation-mapping experiment in the ultraviolet based on 171 observations of the Seyfert 1 galaxy NGC 5548 with the Cosmic Origins Spectrograph on the Hubble Space Telescope. Significant correlated variability is found in the continuum and

Analysis of repeated measures data

CERN Document Server

Islam, M Ataharul

2017-01-01

This book presents a broad range of statistical techniques to address emerging needs in the field of repeated measures. It also provides a comprehensive overview of extensions of generalized linear models for the bivariate exponential family of distributions, which represent a new development in analysing repeated measures data. The demand for statistical models for correlated outcomes has grown rapidly recently, mainly due to presence of two types of underlying associations: associations between outcomes, and associations between explanatory variables and outcomes. The book systematically addresses key problems arising in the modelling of repeated measures data, bearing in mind those factors that play a major role in estimating the underlying relationships between covariates and outcome variables for correlated outcome data. In addition, it presents new approaches to addressing current challenges in the field of repeated measures and models based on conditional and joint probabilities. Markov models of first...

What we have learned about scheduling elective repeat cesarean delivery at term.

Science.gov (United States)

Tita, Alan T N

2016-08-01

The optimal timing of delivery in the setting of various clinical conditions and scenarios remains one of the most common questions for obstetric providers. Over the past 5-10 years, the optimal timing of delivery at term, particularly for elective repeat cesareans, has been the subject of considerable investigation and discussion. There is an increasing consensus that when women opt for an elective repeat cesarean delivery, it should be performed at term rather than preterm. The recent redefinition of the "term" period into early term (37-38 weeks), full-term (39-40 weeks), late term (41 weeks), and post term designations (≥42 weeks) underscores observed heterogeneity in outcomes following delivery at term. The American College of Obstetricians and Gynecologists currently recommends that elective repeat cesarean delivery be performed at full-term. Herein, the available data to support this recommendation regarding timing of elective repeat cesarean delivery are reviewed, including contributions from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Copyright © 2016. Published by Elsevier Inc.

Gender-sensitive observations in public spaces as a teaching tool

NARCIS (Netherlands)

Droogleever Fortuijn, J.

2009-01-01

Public spaces can be seen as arenas where gendered social roles, relations and identities are (re)produced, represented and contested. Because of their (assumed) public character - crowded, open, accessible and visible - these spaces are extremely useful as «observatories» for teaching and learning

Hand gesture recognition in confined spaces with partial observability and occultation constraints

Science.gov (United States)

Shirkhodaie, Amir; Chan, Alex; Hu, Shuowen

2016-05-01

Human activity detection and recognition capabilities have broad applications for military and homeland security. These tasks are very complicated, however, especially when multiple persons are performing concurrent activities in confined spaces that impose significant obstruction, occultation, and observability uncertainty. In this paper, our primary contribution is to present a dedicated taxonomy and kinematic ontology that are developed for in-vehicle group human activities (IVGA). Secondly, we describe a set of hand-observable patterns that represents certain IVGA examples. Thirdly, we propose two classifiers for hand gesture recognition and compare their performance individually and jointly. Finally, we present a variant of Hidden Markov Model for Bayesian tracking, recognition, and annotation of hand motions, which enables spatiotemporal inference to human group activity perception and understanding. To validate our approach, synthetic (graphical data from virtual environment) and real physical environment video imagery are employed to verify the performance of these hand gesture classifiers, while measuring their efficiency and effectiveness based on the proposed Hidden Markov Model for tracking and interpreting dynamic spatiotemporal IVGA scenarios.

Magnetospheric Multiscale (MMS) Observation of Plasma Velocity-Space Cascade Processes

Science.gov (United States)

Parashar, T. N.; Servidio, S.; Matthaeus, W. H.; Chasapis, A.; Perrone, D.; Valentini, F.; Veltri, P.; Gershman, D. J.; Schwartz, S. J.; Giles, B. L.; Fuselier, S. A.; Phan, T.; Burch, J.

2017-12-01

Plasma turbulence is investigated using high-resolution ion velocity distributions, measured by theMagnetospheric Multiscale Mission (MMS) in the Earth's magnetosheath. The particle distributionmanifests large fluctuations, suggesting a cascade-like process in velocity space, invoked by theoristsfor many years. This complex velocity space structure is investigated using a three-dimensional Hermitetransform that reveals a power law distribution of moments. A Kolmogorov approach leads directlyto a range of predictions for this phase-space cascade. The scaling theory is in agreement withobservations, suggesting a new path for the study of plasma turbulence in weakly collisional spaceand astrophysical plasmas.

Repeatability and Reproducibility in Proteomic Identifications by Liquid Chromatography—Tandem Mass Spectrometry

Science.gov (United States)

Tabb, David L.; Vega-Montoto, Lorenzo; Rudnick, Paul A.; Variyath, Asokan Mulayath; Ham, Amy-Joan L.; Bunk, David M.; Kilpatrick, Lisa E.; Billheimer, Dean D.; Blackman, Ronald K.; Cardasis, Helene L.; Carr, Steven A.; Clauser, Karl R.; Jaffe, Jacob D.; Kowalski, Kevin A.; Neubert, Thomas A.; Regnier, Fred E.; Schilling, Birgit; Tegeler, Tony J.; Wang, Mu; Wang, Pei; Whiteaker, Jeffrey R.; Zimmerman, Lisa J.; Fisher, Susan J.; Gibson, Bradford W.; Kinsinger, Christopher R.; Mesri, Mehdi; Rodriguez, Henry; Stein, Steven E.; Tempst, Paul; Paulovich, Amanda G.; Liebler, Daniel C.; Spiegelman, Cliff

2009-01-01

The complexity of proteomic instrumentation for LC-MS/MS introduces many possible sources of variability. Data-dependent sampling of peptides constitutes a stochastic element at the heart of discovery proteomics. Although this variation impacts the identification of peptides, proteomic identifications are far from completely random. In this study, we analyzed interlaboratory data sets from the NCI Clinical Proteomic Technology Assessment for Cancer to examine repeatability and reproducibility in peptide and protein identifications. Included data spanned 144 LC-MS/MS experiments on four Thermo LTQ and four Orbitrap instruments. Samples included yeast lysate, the NCI-20 defined dynamic range protein mix, and the Sigma UPS 1 defined equimolar protein mix. Some of our findings reinforced conventional wisdom, such as repeatability and reproducibility being higher for proteins than for peptides. Most lessons from the data, however, were more subtle. Orbitraps proved capable of higher repeatability and reproducibility, but aberrant performance occasionally erased these gains. Even the simplest protein digestions yielded more peptide ions than LC-MS/MS could identify during a single experiment. We observed that peptide lists from pairs of technical replicates overlapped by 35–60%, giving a range for peptide-level repeatability in these experiments. Sample complexity did not appear to affect peptide identification repeatability, even as numbers of identified spectra changed by an order of magnitude. Statistical analysis of protein spectral counts revealed greater stability across technical replicates for Orbitraps, making them superior to LTQ instruments for biomarker candidate discovery. The most repeatable peptides were those corresponding to conventional tryptic cleavage sites, those that produced intense MS signals, and those that resulted from proteins generating many distinct peptides. Reproducibility among different instruments of the same type lagged behind

Optimization of sequence alignment for simple sequence repeat regions

Directory of Open Access Journals (Sweden)

Ogbonnaya Francis C

2011-07-01

Full Text Available Abstract Background Microsatellites, or simple sequence repeats (SSRs, are tandemly repeated DNA sequences, including tandem copies of specific sequences no longer than six bases, that are distributed in the genome. SSR has been used as a molecular marker because it is easy to detect and is used in a range of applications, including genetic diversity, genome mapping, and marker assisted selection. It is also very mutable because of slipping in the DNA polymerase during DNA replication. This unique mutation increases the insertion/deletion (INDELs mutation frequency to a high ratio - more than other types of molecular markers such as single nucleotide polymorphism (SNPs. SNPs are more frequent than INDELs. Therefore, all designed algorithms for sequence alignment fit the vast majority of the genomic sequence without considering microsatellite regions, as unique sequences that require special consideration. The old algorithm is limited in its application because there are many overlaps between different repeat units which result in false evolutionary relationships. Findings To overcome the limitation of the aligning algorithm when dealing with SSR loci, a new algorithm was developed using PERL script with a Tk graphical interface. This program is based on aligning sequences after determining the repeated units first, and the last SSR nucleotides positions. This results in a shifting process according to the inserted repeated unit type. When studying the phylogenic relations before and after applying the new algorithm, many differences in the trees were obtained by increasing the SSR length and complexity. However, less distance between different linage had been observed after applying the new algorithm. Conclusions The new algorithm produces better estimates for aligning SSR loci because it reflects more reliable evolutionary relations between different linages. It reduces overlapping during SSR alignment, which results in a more realistic

Verbal-spatial and visuospatial coding of power-space interactions.

Science.gov (United States)

Dai, Qiang; Zhu, Lei

2018-05-10

A power-space interaction, which denotes the phenomenon that people responded faster to powerful words when they are placed higher in a visual field and faster to powerless words when they are placed lower in a visual field, has been repeatedly found. The dominant explanation of this power-space interaction is that it results from a tight correspondence between the representation of power and visual space (i.e., a visuospatial coding account). In the present study, we demonstrated that the interaction between power and space could be also based on a verbal-spatial coding in absence of any vertical spatial information. Additionally, the verbal-spatial coding was dominant in driving the power-space interaction when verbal space was contrasted with the visual space. Copyright © 2018 Elsevier Inc. All rights reserved.

Probing Very Bright End of Galaxy Luminosity Function at z >~ 7 Using Hubble Space Telescope Pure Parallel Observations

Science.gov (United States)

Yan, Haojing; Yan, Lin; Zamojski, Michel A.; Windhorst, Rogier A.; McCarthy, Patrick J.; Fan, Xiaohui; Röttgering, Huub J. A.; Koekemoer, Anton M.; Robertson, Brant E.; Davé, Romeel; Cai, Zheng

2011-02-01

We report the first results from the Hubble Infrared Pure Parallel Imaging Extragalactic Survey, which utilizes the pure parallel orbits of the Hubble Space Telescope to do deep imaging along a large number of random sightlines. To date, our analysis includes 26 widely separated fields observed by the Wide Field Camera 3, which amounts to 122.8 arcmin2 in total area. We have found three bright Y 098-dropouts, which are candidate galaxies at z >~ 7.4. One of these objects shows an indication of peculiar variability and its nature is uncertain. The other two objects are among the brightest candidate galaxies at these redshifts known to date (L>2L*). Such very luminous objects could be the progenitors of the high-mass Lyman break galaxies observed at lower redshifts (up to z ~ 5). While our sample is still limited in size, it is much less subject to the uncertainty caused by "cosmic variance" than other samples because it is derived using fields along many random sightlines. We find that the existence of the brightest candidate at z ≈ 7.4 is not well explained by the current luminosity function (LF) estimates at z ≈ 8. However, its inferred surface density could be explained by the prediction from the LFs at z ≈ 7 if it belongs to the high-redshift tail of the galaxy population at z ≈ 7. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with programs 11700 and 11702.

DNA Replication Dynamics of the GGGGCC Repeat of the C9orf72 Gene.

Science.gov (United States)

Thys, Ryan Griffin; Wang, Yuh-Hwa

2015-11-27

DNA has the ability to form a variety of secondary structures in addition to the normal B-form DNA, including hairpins and quadruplexes. These structures are implicated in a number of neurological diseases and cancer. Expansion of a GGGGCC repeat located at C9orf72 is associated with familial amyotrophic lateral sclerosis and frontotemporal dementia. This repeat expands from two to 24 copies in normal individuals to several hundreds or thousands of repeats in individuals with the disease. Biochemical studies have demonstrated that as little as four repeats have the ability to form a stable DNA secondary structure known as a G-quadruplex. Quadruplex structures have the ability to disrupt normal DNA processes such as DNA replication and transcription. Here we examine the role of GGGGCC repeat length and orientation on DNA replication using an SV40 replication system in human cells. Replication through GGGGCC repeats leads to a decrease in overall replication efficiency and an increase in instability in a length-dependent manner. Both repeat expansions and contractions are observed, and replication orientation is found to influence the propensity for expansions or contractions. The presence of replication stress, such as low-dose aphidicolin, diminishes replication efficiency but has no effect on instability. Two-dimensional gel electrophoresis analysis demonstrates a replication stall with as few as 20 GGGGCC repeats. These results suggest that replication of the GGGGCC repeat at C9orf72 is perturbed by the presence of expanded repeats, which has the potential to result in further expansion, leading to disease. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Suppression of Repeat-Intensive False Targets Based on Temporal Pulse Diversity

Directory of Open Access Journals (Sweden)

Gang Lu

2013-01-01

Full Text Available This paper considers the problem of suppressing the repeat-intensive false targets produced by a deception electronic attack (EA system equipped with a Digital Radio Frequency Memory (DRFM device. Different from a conventional repeat jammer, this type of jamming intensively retransmits the intercepted signal stored in a DRFM to the victim radar in a very short time-delay interval relative to a radar pulse wide. A multipeak matched-filtering output is then produced other than the merely expected true target. An electronic protection (EP algorithm based on the space time block code (STBC is proposed to suppress the adverse effects of this jammer. By transmitting a pulse sequence generated from the STBC in succession and the following cancellation process applied upon the received signal, this algorithm performs successfully in a single antenna system provided that the target models are nonfluctuating or slow fluctuating and the pulse repetition frequency (PRF is comparatively high. The performance in white and correlated Gaussian disturbance is evaluated by means of Monte Carlo simulations.

C-terminal low-complexity sequence repeats of Mycobacterium smegmatis Ku modulate DNA binding.

Science.gov (United States)

Kushwaha, Ambuj K; Grove, Anne

2013-01-24

Ku protein is an integral component of the NHEJ (non-homologous end-joining) pathway of DSB (double-strand break) repair. Both eukaryotic and prokaryotic Ku homologues have been characterized and shown to bind DNA ends. A unique feature of Mycobacterium smegmatis Ku is its basic C-terminal tail that contains several lysine-rich low-complexity PAKKA repeats that are absent from homologues encoded by obligate parasitic mycobacteria. Such PAKKA repeats are also characteristic of mycobacterial Hlp (histone-like protein) for which they have been shown to confer the ability to appose DNA ends. Unexpectedly, removal of the lysine-rich extension enhances DNA-binding affinity, but an interaction between DNA and the PAKKA repeats is indicated by the observation that only full-length Ku forms multiple complexes with a short stem-loop-containing DNA previously designed to accommodate only one Ku dimer. The C-terminal extension promotes DNA end-joining by T4 DNA ligase, suggesting that the PAKKA repeats also contribute to efficient end-joining. We suggest that low-complexity lysine-rich sequences have evolved repeatedly to modulate the function of unrelated DNA-binding proteins.

A CGG-repeat expansion mutation in ZNF713 causes FRA7A: association with autistic spectrum disorder in two families.

Science.gov (United States)

Metsu, Sofie; Rainger, Jacqueline K; Debacker, Kim; Bernhard, Birgitta; Rooms, Liesbeth; Grafodatskaya, Daria; Weksberg, Rosanna; Fombonne, Eric; Taylor, Martin S; Scherer, Stephen W; Kooy, R Frank; FitzPatrick, David R

2014-11-01

We report de novo occurrence of the 7p11.2 folate-sensitive fragile site FRA7A in a male with an autistic spectrum disorder (ASD) due to a CGG-repeat expansion mutation (∼450 repeats) in a 5' intron of ZNF713. This expanded allele showed hypermethylation of the adjacent CpG island with reduced ZNF713 expression observed in a proband-derived lymphoblastoid cell line (LCL). His unaffected mother carried an unmethylated premutation (85 repeats). This CGG-repeat showed length polymorphism in control samples (five to 22 repeats). In a second unrelated family, three siblings with ASD and their unaffected father were found to carry FRA7A premutations, which were partially or mosaically methylated. In one of the affected siblings, mitotic instability of the premutation was observed. ZNF713 expression in LCLs in this family was increased in three of these four premutation carriers. A firm link cannot yet be established between ASD and the repeat expansion mutation but plausible pathogenic mechanisms are discussed. © 2014 WILEY PERIODICALS, INC.

Repeated mild closed head injury impairs short-term visuospatial memory and complex learning.

Science.gov (United States)

Hylin, Michael J; Orsi, Sara A; Rozas, Natalia S; Hill, Julia L; Zhao, Jing; Redell, John B; Moore, Anthony N; Dash, Pramod K

2013-05-01

Concussive force can cause neurocognitive and neurobehavioral dysfunction by inducing functional, electrophysiological, and/or ultrastructural changes within the brain. Although concussion-triggered symptoms typically subside within days to weeks in most people, in 15%-20% of the cases, symptomology can continue beyond this time point. Problems with memory, attention, processing speed, and cognitive flexibility (e.g., problem solving, conflict resolution) are some of the prominent post-concussive cognitive symptoms. Repeated concussions (with loss or altered consciousness), which are common to many contact sports, can exacerbate these symptoms. The pathophysiology of repeated concussions is not well understood, nor is an effective treatment available. In order to facilitate drug discovery to treat post-concussive symptoms (PCSs), there is a need to determine if animal models of repeated mild closed head injury (mCHI) can mimic the neurocognitive and histopathological consequences of repeated concussions. To this end, we employed a controlled cortical impact (CCI) device to deliver a mCHI directly to the skull of mice daily for 4 days, and examined the ensuing neurological and neurocognitive functions using beam balance, foot-fault, an abbreviated Morris water maze test, context discrimination, and active place avoidance tasks. Repeated mCHI exacerbated vestibulomotor, motor, short-term memory and conflict learning impairments as compared to a single mCHI. Learning and memory impairments were still observed in repeated mCHI mice when tested 3 months post-injury. Repeated mCHI also reduced cerebral perfusion, prolonged the inflammatory response, and in some animals, caused hippocampal neuronal loss. Our results show that repeated mCHI can reproduce some of the deficits seen after repeated concussions in humans and may be suitable for drug discovery studies and translational research.

A Strategy for Thailand's Space Technology Development: National Space Program (NSP)

Science.gov (United States)

Pimnoo, Ammarin; Purivigraipong, Somphop

2016-07-01

The Royal Thai Government has established the National Space Policy Committee (NSPC) with mandates for setting policy and strategy. The NSPC is considering plans and budget allocation for Thai space development. NSPC's goal is to promote the utilization of space technology in a manner that is congruent with the current situation and useful for the economy, society, science, technology, educational development and national security. The first proposed initiative of the National Space Program (NSP) is co-development of THEOS-2, a next-generation satellite system that includes Thailand's second and third earth observation satellite (THAICHOTE-2 and THAICHOTE-3). THEOS-1 or THAICHOTE-1 was the first Earth Observation Satellite of Thailand launched in 2008. At present, the THAICHOTE-1 is over the lifetime, therefore the THEOS-2 project has been established. THEOS-2 is a complete Earth Observation System comprising THAICHOTE-2&3 as well as ground control segment and capacity building. Thus, NSPC has considered that Thailand should manage the space system. Geo-Informatics and Space Technology Development Agency (GISTDA) has been assigned to propose the initiative National Space Program (NSP). This paper describes the strategy of Thailand's National Space Program (NSP) which will be driven by GISTDA. First, NSP focuses on different aspects of the utilization of space on the basis of technology, innovation, knowledge and manpower. It contains driving mechanisms related to policy, implementation and use in order to promote further development. The Program aims to increase economic competitiveness, reduce social disparity, and improve social security, natural resource management and environmental sustainability. The NSP conceptual framework includes five aspects: communications satellites, earth observation satellite systems, space economy, space exploration and research, and NSP administration. THEOS-2 is considered a part of NSP with relevance to the earth observation

Geometrical conditions for completely positive trace-preserving maps and their application to a quantum repeater and a state-dependent quantum cloning machine

International Nuclear Information System (INIS)

Carlini, A.; Sasaki, M.

2003-01-01

We address the problem of finding optimal CPTP (completely positive trace-preserving) maps between a set of binary pure states and another set of binary generic mixed state in a two-dimensional space. The necessary and sufficient conditions for the existence of such CPTP maps can be discussed within a simple geometrical picture. We exploit this analysis to show the existence of an optimal quantum repeater which is superior to the known repeating strategies for a set of coherent states sent through a lossy quantum channel. We also show that the geometrical formulation of the CPTP mapping conditions can be a simpler method to derive a state-dependent quantum (anti) cloning machine than the study so far based on the explicit solution of several constraints imposed by unitarity in an extended Hilbert space

Ecology and economic estimate of using of the underground excavation space

International Nuclear Information System (INIS)

Umnov, V.A.; Tarasov, V.F.; Tret'yakov, I.O.; Sheloumov, A.A.

1995-01-01

Stages of ecological and economic estimates of utilizing underground space, including evaluation of underground space resources, selection of its utilization trends and substantiation of optimal parameters for selected trends, are considered. Certain directions of possible repeated utilization of mining excavations are shown, including underground hydropower stations, underground energy storages, underground nuclear stations. Underground waste disposal is one of the most available directions in utilization of the underground space presently. Evaluation of the underground space utilization at all stages envisages complete account of all economical, social and ecological results

simple sequence repeats (EST-SSR)

African Journals Online (AJOL)

Yomi

2012-01-19

Jan 19, 2012 ... 212 primer pairs selected, based on repeat patterns of n≥8 for di-, tri-, tetra- and penta-nucleotide repeat ... Cluster analysis revealed a high genetic similarity among the sugarcane (Saccharum spp.) breeding lines which could reduce the genetic gain in ..... The multiple allele characteristic of SSR com-.

Nifty Nines and Repeating Decimals

Science.gov (United States)

Brown, Scott A.

2016-01-01

The traditional technique for converting repeating decimals to common fractions can be found in nearly every algebra textbook that has been published, as well as in many precalculus texts. However, students generally encounter repeating decimal numerals earlier than high school when they study rational numbers in prealgebra classes. Therefore, how…

Repeated Prescribed Burning in Aspen

Science.gov (United States)

Donald A. Perala

1974-01-01

Infrequent burning weather, low flammability of the aspen-hardwood association, and prolific sprouting and seeding of shrubs and hardwoods made repeated dormant season burning a poor tool to convert good site aspen to conifers. Repeat fall burns for wildlife habitat maintenance is workable if species composition changes are not important.

Time-Variable Gravity from Space: Quarter Century of Observations, Mysteries, and Prospects

Science.gov (United States)

Chao, Benjamin F.; Boy, John-Paul

2003-01-01

Any large mass transport in the Earth system produces changes in the gravity field. Via the space geodetic technique of satellite-laser ranging in the last quarter century, the Earth's dynamic oblateness J2 (the lowest-degree harmonic component of the gravity field) has been observed to undergo a slight decrease -- until around 1998, when it switched quite suddenly to an increase trend which has continued to 2001 before sharply turning back to the value which it is "supposed to be"!. The secular decrease in J2 has long been attributed primarily to the post-glacial rebound in the mantle; the present increase signifies an even larger change in global mass distribution whose J2 effect overshadows that of the post-glacial rebound, at least over interannual timescales. Intriguing evidences have been found in the ocean water distribution, especially in the extratropical Pacific basins, that may be responsible for this J2 change. New techniques based on satellite-to-satellite tracking will yield greatly improved observations for time-variable gravity, with much higher precision and spatial resolution (i.e., much higher harmonic degrees). The most important example is the GRACE mission launched in March 2002, following the success of the CHAMP mission. Such observations are becoming a new and powerful tool for remote sensing of geophysical fluid processes that involve larger-scale mass transports.

Sentinel-2: next generation satellites for optical land observation from space

Science.gov (United States)

Lautenschläger, G.; Gessner, R.; Gockel, W.; Haas, C.; Schweickert, G.; Bursch, S.; Welsch, M.; Sontag, H.

2013-10-01

The first Sentinel-2 satellites, which constitute the next generation of operational Earth observation satellites for optical land monitoring from space, are undergoing completion in the facilities at Astrium ready for launch end 2014. Sentinel-2 will feature a major breakthrough in the area of optical land observation since it will for the first time enable continuous and systematic acquisition of all land surfaces world-wide with the Multi-Spectral Instrument (MSI), thus providing the basis for a truly operational service. Flying in the same orbital plane and spaced at 180°, the constellation of two satellites, designed for an in-orbit nominal operational lifetime of 7 years each, will acquire all land surfaces in only 5 days at the equator. In order to support emergency operations, the satellites can further be operated in an extended observation mode allowing to image any point on Earth even on a daily basis. MSI acquires images in 13 spectral channels from Visible-to-Near Infrared (VNIR) to Short Wave Infrared (SWIR) with a swath of almost 300 km on ground and a spatial resolution up to 10 m. The data ensure continuity to the existing data sets produced by the series of Landsat and SPOT satellites, and will further provide detailed spectral information to enable derivation of biophysical or geophysical products. Excellent geometric image quality performances are achieved with geolocation better than 16 m, thanks to an innovative instrument design in conjunction with a high-performance satellite AOCS subsystem centered around a 2-band GPS receiver, high-performance star trackers and a fiberoptic gyro. To cope with the high data volume on-board, data are compressed using a state-of-the-art wavelet compression scheme. Thanks to a powerful mission data handling system built around a newly developed very large solid-state mass memory based on flash technology, on-board compression losses will be kept to a minimum. The Sentinel-2 satellite design features a highly

Earth Observation from the International Space Station -Remote Sensing in Schools-

Science.gov (United States)

Schultz, Johannes; Rienow, Andreas; Graw, Valerie; Heinemann, Sascha; Selg, Fabian; Menz, Gunter

2016-04-01

Since spring 2014, the NASA High Definition Earth Viewing (HDEV) mission at the International Space Station (ISS) is online. HDEV consists of four cameras mounted at ESA's Columbus laboratory and is recording the earth 24/7. The educational project 'Columbus Eye - Live-Imagery from the ISS in Schools' has published a learning portal for earth observation from the ISS (www.columbuseye.uni-bonn.de). Besides a video live stream, the portal contains an archive providing spectacular footage, web-GIS and an observatory with interactive materials for school lessons. Columbus Eye is carried out by the University of Bonn and funded by the German Aerospace Center (DLR) Space Administration. Pupils should be motivated to work with the footage in order to learn about patterns and processes of the coupled human-environment system like volcano eruptions or deforestation. The material is developed on the experiences of the FIS (German abbreviation for "Remote Sensing in Schools") project and its learning portal (http://www.fis.uni-bonn.de). Based on the ISS videos three different teaching material types are developed. The simplest teaching type are provided by worksheets, which have a low degree of interactivity. Alongside a short didactical commentary for teachers is included. Additionally, videos, ancillary information, maps, and instructions for interactive school experiments are provided. The observatory contains the second type of the Columbus Eye teaching materials. It requires a high degree of self-organisation and responsibility of the pupils. Thus, the observatory provides the opportunity for pupils to freely construct their own hypotheses based on a spatial analysis tool similar to those provided by commercial software. The third type are comprehensive learning and teaching modules with a high degree of interactivity, including background information, interactive animations, quizzes and different analysis tools (e.g. change detection, classification, polygon or NDVI

Repeatability and correlations of dynamic contrast enhanced and T2* MRI in patients with advanced pancreatic ductal adenocarcinoma.

Science.gov (United States)

Klaassen, Remy; Gurney-Champion, Oliver J; Wilmink, Johanna W; Besselink, Marc G; Engelbrecht, Marc R W; Stoker, Jaap; Nederveen, Aart J; van Laarhoven, Hanneke W M

2018-07-01

In current oncological practice of pancreatic ductal adenocarcinoma (PDAC), there is a great demand for response predictors and markers for early treatment evaluation. In this study, we investigated the repeatability and the interaction of dynamic contrast enhanced (DCE) and T2* MRI in patients with advanced PDAC to enable for such evaluation using these techniques. 15 PDAC patients underwent two DCE, T2* and anatomical 3 T MRI sessions before start of treatment. Parametric maps were calculated for the transfer constant (K trans ), rate constant (k ep ), extracellular extravascular space (v e ) and perfusion fraction (v p ). Quantitative R2* (1/T2*) maps were obtained from the multi-echo T2* images. Differences between normal and cancerous pancreas were determined using a Wilcoxon matched pairs test. Repeatability was obtained using Bland-Altman analysis and relations between DCE and T2*/R2* were observed by Spearman correlation and voxel-wise binned plots of tumor voxels. PDAC K trans (p = 0.007), k ep (p T2*. Voxel wise analysis showed a steep increase in R2* for tumor voxels with lower K trans and v e . We showed good repeatability of DCE and T2* related MRI parameters in advanced PDAC patients. Furthermore, we have illustrated the relation of DCE K trans and v e with tissue T2* and R2* indicating substantial value of these parameters for detecting tumor hypoxia in future studies. The results from our study pave the way for further response evaluation studies and patient selection based on DCE and T2* parameters. Copyright © 2018 Elsevier Inc. All rights reserved.

Thermal, cardiac and adrenergic responses to repeated local cooling.

Science.gov (United States)

Janský, L; Matousková, E; Vávra, V; Vybíral, S; Janský, P; Jandová, D; Knízková, I; Kunc, P

2006-01-01

The aim of this study was to ascertain whether repeated local cooling induces the same or different adaptational responses as repeated whole body cooling. Repeated cooling of the legs (immersion into 12 degrees C water up to the knees for 30 min, 20 times during 4 weeks = local cold adaptation - LCA) attenuated the initial increase in heart rate and blood pressure currently observed in control subjects immersed in cold water up to the knees. After LCA the initial skin temperature decrease tended to be lower, indicating reduced vasoconstriction. Heart rate and systolic blood pressure appeared to be generally lower during rest and during the time course of cooling in LCA humans, when compared to controls. All these changes seem to indicate attenuation of the sympathetic tone. In contrast, the sustained skin temperature in different areas of the body (finger, palm, forearm, thigh, chest) appeared to be generally lower in LCA subjects than in controls (except for temperatures on the forehead). Plasma levels of catecholamines (measured 20 and 40 min after the onset of cooling) were also not influenced by local cold adaptation. Locally cold adapted subjects, when exposed to whole body cold water immersion test, showed no change in the threshold temperature for induction of cold thermogenesis. This indicates that the hypothermic type of cold adaptation, typically occurring after systemic cold adaptation, does not appear after local cold adaptation of the intensity used. It is concluded that in humans the cold adaptation due to repeated local cooling of legs induces different physiological changes than systemic cold adaptation.

Investigation of a Quadruplex-Forming Repeat Sequence Highly Enriched in Xanthomonas and Nostoc sp.

Directory of Open Access Journals (Sweden)

Charlotte Rehm

Full Text Available In prokaryotes simple sequence repeats (SSRs with unit sizes of 1-5 nucleotides (nt are causative for phase and antigenic variation. Although an increased abundance of heptameric repeats was noticed in bacteria, reports about SSRs of 6-9 nt are rare. In particular G-rich repeat sequences with the propensity to fold into G-quadruplex (G4 structures have received little attention. In silico analysis of prokaryotic genomes show putative G4 forming sequences to be abundant. This report focuses on a surprisingly enriched G-rich repeat of the type GGGNATC in Xanthomonas and cyanobacteria such as Nostoc. We studied in detail the genomes of Xanthomonas campestris pv. campestris ATCC 33913 (Xcc, Xanthomonas axonopodis pv. citri str. 306 (Xac, and Nostoc sp. strain PCC7120 (Ana. In all three organisms repeats are spread all over the genome with an over-representation in non-coding regions. Extensive variation of the number of repetitive units was observed with repeat numbers ranging from two up to 26 units. However a clear preference for four units was detected. The strong bias for four units coincides with the requirement of four consecutive G-tracts for G4 formation. Evidence for G4 formation of the consensus repeat sequences was found in biophysical studies utilizing CD spectroscopy. The G-rich repeats are preferably located between aligned open reading frames (ORFs and are under-represented in coding regions or between divergent ORFs. The G-rich repeats are preferentially located within a distance of 50 bp upstream of an ORF on the anti-sense strand or within 50 bp from the stop codon on the sense strand. Analysis of whole transcriptome sequence data showed that the majority of repeat sequences are transcribed. The genetic loci in the vicinity of repeat regions show increased genomic stability. In conclusion, we introduce and characterize a special class of highly abundant and wide-spread quadruplex-forming repeat sequences in bacteria.

Investigation of a Quadruplex-Forming Repeat Sequence Highly Enriched in Xanthomonas and Nostoc sp.

Science.gov (United States)

Rehm, Charlotte; Wurmthaler, Lena A; Li, Yuanhao; Frickey, Tancred; Hartig, Jörg S

2015-01-01

In prokaryotes simple sequence repeats (SSRs) with unit sizes of 1-5 nucleotides (nt) are causative for phase and antigenic variation. Although an increased abundance of heptameric repeats was noticed in bacteria, reports about SSRs of 6-9 nt are rare. In particular G-rich repeat sequences with the propensity to fold into G-quadruplex (G4) structures have received little attention. In silico analysis of prokaryotic genomes show putative G4 forming sequences to be abundant. This report focuses on a surprisingly enriched G-rich repeat of the type GGGNATC in Xanthomonas and cyanobacteria such as Nostoc. We studied in detail the genomes of Xanthomonas campestris pv. campestris ATCC 33913 (Xcc), Xanthomonas axonopodis pv. citri str. 306 (Xac), and Nostoc sp. strain PCC7120 (Ana). In all three organisms repeats are spread all over the genome with an over-representation in non-coding regions. Extensive variation of the number of repetitive units was observed with repeat numbers ranging from two up to 26 units. However a clear preference for four units was detected. The strong bias for four units coincides with the requirement of four consecutive G-tracts for G4 formation. Evidence for G4 formation of the consensus repeat sequences was found in biophysical studies utilizing CD spectroscopy. The G-rich repeats are preferably located between aligned open reading frames (ORFs) and are under-represented in coding regions or between divergent ORFs. The G-rich repeats are preferentially located within a distance of 50 bp upstream of an ORF on the anti-sense strand or within 50 bp from the stop codon on the sense strand. Analysis of whole transcriptome sequence data showed that the majority of repeat sequences are transcribed. The genetic loci in the vicinity of repeat regions show increased genomic stability. In conclusion, we introduce and characterize a special class of highly abundant and wide-spread quadruplex-forming repeat sequences in bacteria.

Freely Chosen Index Finger Tapping Frequency Is Increased in Repeated Bouts of Tapping.

Science.gov (United States)

Hansen, Ernst Albin; Ebbesen, Brian Duborg; Dalsgaard, Ane; Mora-Jensen, Mark Holten; Rasmussen, Jakob

2015-01-01

Healthy individuals (n = 40) performed index finger tapping at freely chosen frequency during repeated bouts and before and after near-maximal muscle action consisting of 3 intense flexions of the index finger metacarpal phalangeal joint. One experiment showed, unexpectedly, that a bout of tapping increased the tapping frequency in the subsequent bout. Thus, a cumulating increase of 8.2 ± 5.4% (p tapping frequency was still increased in consecutive bouts when rest periods were extended to 20 min. Besides, near-maximal muscle activation, followed by 5 min rest, did not affect the tapping frequency. In conclusion, freely chosen tapping frequency was increased in repeated bouts of tapping, which were separated by 10-20 min rest periods. The observed phenomenon is suggested to be termed repeated bout rate enhancement.

Characterizing the Trade Space Between Capability and Complexity in Next Generation Cloud and Precipitation Observing Systems Using Markov Chain Monte Carlos Techniques

Science.gov (United States)

Xu, Z.; Mace, G. G.; Posselt, D. J.

2017-12-01

As we begin to contemplate the next generation atmospheric observing systems, it will be critically important that we are able to make informed decisions regarding the trade space between scientific capability and the need to keep complexity and cost within definable limits. To explore this trade space as it pertains to understanding key cloud and precipitation processes, we are developing a Markov Chain Monte Carlo (MCMC) algorithm suite that allows us to arbitrarily define the specifications of candidate observing systems and then explore how the uncertainties in key retrieved geophysical parameters respond to that observing system. MCMC algorithms produce a more complete posterior solution space, and allow for an objective examination of information contained in measurements. In our initial implementation, MCMC experiments are performed to retrieve vertical profiles of cloud and precipitation properties from a spectrum of active and passive measurements collected by aircraft during the ACE Radiation Definition Experiments (RADEX). Focusing on shallow cumulus clouds observed during the Integrated Precipitation and Hydrology EXperiment (IPHEX), observing systems in this study we consider W and Ka-band radar reflectivity, path-integrated attenuation at those frequencies, 31 and 94 GHz brightness temperatures as well as visible and near-infrared reflectance. By varying the sensitivity and uncertainty of these measurements, we quantify the capacity of various combinations of observations to characterize the physical properties of clouds and precipitation.

Behavioral sensitization after repeated formaldehyde exposure in rats.

Science.gov (United States)

Sorg, B A; Hochstatter, T

1999-01-01

Multiple chemical sensitivity (MCS) is a phenomenon whereby individuals report increased sensitivity to chemicals in the environment, and attribute their sensitivities to prior exposure to the same or often structurally unrelated chemicals. A leading hypothesis suggests that MCS is akin to behavioral sensitization observed in rodents after repeated exposure to drugs of abuse or environmental stressors. Sensitization occurring within limbic circuitry of the central nervous system (CNS) may explain the multisymptom complaints in individuals with MCS. The present studies represent the continuing development of an animal model for MCS, the basis of which is the CNS sensitization hypothesis. Three behaviors were assessed in rats repeatedly exposed to formaldehyde (Form) inhalation. In the first series of experiments, rats were given high-dose Form exposure (11 parts per million [ppm]; 1 h/day x 7 days) or low-dose Form exposure (1 ppm; either 1 h/day x 7 days or 1 h/day x 5 days/week x 4 weeks). Within a few days after discontinuing daily Form, cocaine-induced locomotor activity was elevated after high-dose Form or 20 days of low-dose Form inhalation. Approximately 1 month later, cocaine-induced locomotor activity remained significantly elevated in the 20-day Form-exposed rats. The second experiment assessed whether prior exposure to Form (20 days, as above) would alter the ability to condition to an odor (orange oil) paired with footshock. The results suggested a tendency to increase the conditioned fear response to the odor but not the context of the footshock box, and a decreased tendency to extinguish the conditioned fear response to odor. The third experiment examined whether CNS sensitization to daily cocaine or stress would alter subsequent avoidance responding to odor (Form). Daily cocaine significantly elevated approach responses to Form, while daily stress pretreatment produced a trend in the opposite direction, producing greater avoidance of Form. Preliminary

Short bowel mucosal morphology, proliferation and inflammation at first and repeat STEP procedures.

Science.gov (United States)

Mutanen, Annika; Barrett, Meredith; Feng, Yongjia; Lohi, Jouko; Rabah, Raja; Teitelbaum, Daniel H; Pakarinen, Mikko P

2018-04-17

Although serial transverse enteroplasty (STEP) improves function of dilated short bowel, a significant proportion of patients require repeat surgery. To address underlying reasons for unsuccessful STEP, we compared small intestinal mucosal characteristics between initial and repeat STEP procedures in children with short bowel syndrome (SBS). Fifteen SBS children, who underwent 13 first and 7 repeat STEP procedures with full thickness small bowel samples at median age 1.5 years (IQR 0.7-3.7) were included. The specimens were analyzed histologically for mucosal morphology, inflammation and muscular thickness. Mucosal proliferation and apoptosis was analyzed with MIB1 and Tunel immunohistochemistry. Median small bowel length increased 42% by initial STEP and 13% by repeat STEP (p=0.05), while enteral caloric intake increased from 6% to 36% (p=0.07) during 14 (12-42) months between the procedures. Abnormal mucosal inflammation was frequently observed both at initial (69%) and additional STEP (86%, p=0.52) surgery. Villus height, crypt depth, enterocyte proliferation and apoptosis as well as muscular thickness were comparable at first and repeat STEP (p>0.05 for all). Patients, who required repeat STEP tended to be younger (p=0.057) with less apoptotic crypt cells (p=0.031) at first STEP. Absence of ileocecal valve associated with increased intraepithelial leukocyte count and reduced crypt cell proliferation index (pSTEP. Persistent inflammation and lacking mucosal growth may contribute to continuing bowel dysfunction in SBS children, who require repeat STEP procedure, especially after removal of the ileocecal valve. Level IV, retrospective study. Copyright © 2018 Elsevier Inc. All rights reserved.

Deriving Global Discharge Records from SWOT Observations

Science.gov (United States)

Pan, M.; Fisher, C. K.; Wood, E. F.

2017-12-01

River flows are poorly monitored in many regions of the world, hindering our ability to accurately estimate water global water usage, and thus estimate global water and energy budgets or the variability in the global water cycle. Recent developments in satellite remote sensing, such as water surface elevations from radar altimetry or surface water extents from visible/infrared imagery, aim to fill this void; however, the streamflow estimates derived from these are inherently intermittent in both space and time. There is then a need for new methods that are able to derive spatially and temporally continuous records of discharge from the many available data sources. One particular application of this will be the Surface Water and Ocean Topography (SWOT) mission, which is designed to provide global observations of water surface elevation and slope from which river discharge can be estimated. Within the 21-day repeat cycle, a river reach will be observed 2-4 times on average. Due to the relationship between the basin orientation and the orbit, these observations are not evenly distributed in time or space. In this study, we investigate how SWOT will observe global river basins and how the temporal and spatial sampling impacts our ability to reconstruct discharge records.River flows can be estimated throughout a basin by assimilating SWOT observations using the Inverse Streamflow Routing (ISR) model of Pan and Wood [2013]. This method is applied to 32 global basins with different geometries and crossing patterns for the future orbit, assimilating theoretical SWOT-retrieved "gauges". Results show that the model is able to reconstruct basin-wide discharge from SWOT observations alone; however, the performance varies significantly across basins and is driven by the orientation, flow distance, and travel time in each, as well as the sensitivity of the reconstruction method to errors in the satellite retrieval. These properties are combined to estimate the "observability" of

Encoding Strategy Changes and Spacing Effects in the Free Recall of Unmixed Lists

Science.gov (United States)

Delaney, P.F.; Knowles, M.E.

2005-01-01

Memory for repeated items often improves when repetitions are separated by other items-a phenomenon called the spacing effect. In two experiments, we explored the complex interaction between study strategies, serial position, and spacing effects. When people studied several unmixed lists, they initially used mainly rote rehearsal, but some people…

Characterization and expression of the maize β-carbonic anhydrase gene repeat regions.

Science.gov (United States)

Tems, Ursula; Burnell, James N

2010-12-01

In maize, carbonic anhydrase (CA; EC 4.2.1.1) catalyzes the first reaction of the C(4) photosynthetic pathway; it catalyzes the hydration of CO(2) to bicarbonate and provides an inorganic carbon source for the primary carboxylation reaction catalyzed by phosphoenolpyruvate (PEP) carboxylase. The β-CA isozymes from maize, as well as other agronomically important NADP-malic enzyme (NADP-ME) type C(4) crops, have remained relatively uncharacterized but differ significantly from the β-CAs of other C(4) monocot species primarily due to transcript length and the presence of repeat sequences. This research confirmed earlier findings of repeat sequences in maize CA transcripts, and demonstrated that the gene encoding these transcripts is also composed of repeat sequences. One of the maize CA genes was sequenced and found to encode two domains, with distinct groups of exons corresponding to the repeat regions of the transcript. We have also shown that expression of a single repeat region of the CA transcript produced active enzyme that associated as a dimer and was composed primarily of α-helices, consistent with that observed for other plant CAs. As the presence of repeat regions in the CA gene is unique to NADP-ME type C(4) monocot species, the implications of these findings in the context of the evolution of the location and function of this C(4) pathway enzyme are strongly suggestive of CA gene duplication resulting in an evolutionary advantage and a higher photosynthetic efficiency. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

The Pentapeptide Repeat Proteins

OpenAIRE

Vetting, Matthew W.; Hegde, Subray S.; Fajardo, J. Eduardo; Fiser, Andras; Roderick, Steven L.; Takiff, Howard E.; Blanchard, John S.

2006-01-01

The Pentapeptide Repeat Protein (PRP) family has over 500 members in the prokaryotic and eukaryotic kingdoms. These proteins are composed of, or contain domains composed of, tandemly repeated amino acid sequences with a consensus sequence of [S,T,A,V][D,N][L,F]-[S,T,R][G]. The biochemical function of the vast majority of PRP family members is unknown. The three-dimensional structure of the first member of the PRP family was determined for the fluoroquinolone resistance protein (MfpA) from Myc...

James Webb Space Telescope Observations of Stellar Occultations by Solar System Bodies and Rings

Science.gov (United States)

Santos-Sanz, P.; French, R. G.; Pinilla-Alonso, N.; Stansberry, J.; Lin, Z-Y.; Zhang, Z-W.; Vilenius, E.; Mueller, Th.; Ortiz, J. L.; Braga-Ribas, F.;

Estimation of High-Frequency Earth-Space Radio Wave Signals via Ground-Based Polarimetric Radar Observations

Science.gov (United States)

Bolen, Steve; Chandrasekar, V.

2002-01-01

Expanding human presence in space, and enabling the commercialization of this frontier, is part of the strategic goals for NASA's Human Exploration and Development of Space (HEDS) enterprise. Future near-Earth and planetary missions will support the use of high-frequency Earth-space communication systems. Additionally, increased commercial demand on low-frequency Earth-space links in the S- and C-band spectra have led to increased interest in the use of higher frequencies in regions like Ku and Ka-band. Attenuation of high-frequency signals, due to a precipitating medium, can be quite severe and can cause considerable disruptions in a communications link that traverses such a medium. Previously, ground radar measurements were made along the Earth-space path and compared to satellite beacon data that was transmitted to a ground station. In this paper, quantitative estimation of the attenuation along the propagation path is made via inter-comparisons of radar data taken from the Tropical Rainfall Measuring Mission (TRMM) Precipitation Radar (PR) and ground-based polarimetric radar observations. Theoretical relationships between the expected specific attenuation (k) of spaceborne measurements with ground-based measurements of reflectivity (Zh) and differential propagation phase shift (Kdp) are developed for various hydrometeors that could be present along the propagation path, which are used to estimate the two-way path-integrated attenuation (PIA) on the PR return echo. Resolution volume matching and alignment of the radar systems is performed, and a direct comparison of PR return echo with ground radar attenuation estimates is made directly on a beam-by-beam basis. The technique is validated using data collected from the TExas and Florida UNderflights (TEFLUN-B) experiment and the TRMM large Biosphere-Atmosphere experiment in Amazonia (LBA) campaign. Attenuation estimation derived from this method can be used for strategiC planning of communication systems for

Relative-locality distant observers and the phenomenology of momentum-space geometry

International Nuclear Information System (INIS)

Amelino-Camelia, Giovanni; Rosati, Giacomo; Trevisan, Gabriele; Arzano, Michele; Kowalski-Glikman, Jerzy

2012-01-01

We study the translational invariance of the relative-locality framework proposed in Amelino-Camelia et al (2011 Phys. Rev. D 84 084010), which had been previously established only for the case of a single interaction. We provide an explicit example of boundary conditions at endpoints of worldlines, which indeed ensures the desired translational invariance for processes involving several interactions, even when some of the interactions are causally connected (particle exchange). We illustrate the properties of the associated relativistic description of distant observers within the example of a κ-Poincare-inspired momentum-space geometry, with de Sitter metric and parallel transport governed by a non-metric and torsionful connection. We find that in such a theory, simultaneously emitted massless particles do not reach simultaneously a distant detector, as expected in light of the findings of Freidel and Smolin (2011 arXiv:1103.5626) on the implications of non-metric connections. We also show that the theory admits a free-particle limit, where the relative-locality results of Amelino-Camelia et al (2011 Phys. Lett. B 700 150) are reproduced. We establish that the torsion of the κ-Poincare connection introduces a small (but observably large) dependence of the time of detection, for simultaneously emitted particles, on some properties of the interactions producing the particles at the source. (paper)

Relative-locality distant observers and the phenomenology of momentum-space geometry

Science.gov (United States)

Amelino-Camelia, Giovanni; Arzano, Michele; Kowalski-Glikman, Jerzy; Rosati, Giacomo; Trevisan, Gabriele

2012-04-01

We study the translational invariance of the relative-locality framework proposed in Amelino-Camelia et al (2011 Phys. Rev. D 84 084010), which had been previously established only for the case of a single interaction. We provide an explicit example of boundary conditions at endpoints of worldlines, which indeed ensures the desired translational invariance for processes involving several interactions, even when some of the interactions are causally connected (particle exchange). We illustrate the properties of the associated relativistic description of distant observers within the example of a κ-Poincaré-inspired momentum-space geometry, with de Sitter metric and parallel transport governed by a non-metric and torsionful connection. We find that in such a theory, simultaneously emitted massless particles do not reach simultaneously a distant detector, as expected in light of the findings of Freidel and Smolin (2011 arXiv:1103.5626) on the implications of non-metric connections. We also show that the theory admits a free-particle limit, where the relative-locality results of Amelino-Camelia et al (2011 Phys. Lett. B 700 150) are reproduced. We establish that the torsion of the κ-Poincaré connection introduces a small (but observably large) dependence of the time of detection, for simultaneously emitted particles, on some properties of the interactions producing the particles at the source.

On the crustal bias of repeat stations in Romania

Directory of Open Access Journals (Sweden)

Venera Dobrica

2013-03-01

Full Text Available A magnetic induction model has been applied to recordings obtained in 2010 during the field campaigns for geomagnetic measurements at the 26 repeat stations of the Romanian secular variation network. The model is based on the observation that a variable external magnetic field induces a response of the Earth's interior not only by electromagnetic induction, but also by magnetic induction in the magnetic rocks above the Curie temperature. The model computes coefficients of a linear relationship between recorded values of a certain geomagnetic element (X, Y, Z, or F at the repeat station and recorded X, Y, Z values at a reference station (in this case, SUA observatory. Coefficients depend on magnetic permeabilities of rocks beneath the station and stand as a proxy for the anomaly bias characterizing the site. Maps of the lateral variation of this type of information were obtained and discussed.

SPACE-BASED MICROLENS PARALLAX OBSERVATION AS A WAY TO RESOLVE THE SEVERE DEGENERACY BETWEEN MICROLENS-PARALLAX AND LENS-ORBITAL EFFECTS

Energy Technology Data Exchange (ETDEWEB)

Han, C. [Department of Physics, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Udalski, A.; Szymański, M. K.; Soszyński, I.; Skowron, J.; Mróz, P.; Poleski, R.; Pietrukowicz, P.; Kozłowski, S.; Ulaczyk, K.; Wyrzykowski, Ł.; Pawlak, M. [Warsaw University Observatory, Al. Ujazdowskie 4, 00-478 Warszawa (Poland); Lee, C.-U.; Gould, A.; Chung, S.-J.; Kim, S.-L.; Cha, S.-M. [Korea Astronomy and Space Science Institute, Daejeon 34055 (Korea, Republic of); Bozza, V. [Dipartimento di Fisica “E. R. Caianiello”, Uńiversitá di Salerno, Via Giovanni Paolo II, I-84084 Fisciano (Italy); Albrow, M. D. [University of Canterbury, Department of Physics and Astronomy, Private Bag 4800, Christchurch 8020 (New Zealand); Jung, Y. K. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA, 02138 (United States); Collaboration: OGLE Collaboration; KMTNet Collaboration; and others

2016-08-10

In this paper, we demonstrate the severity of the degeneracy between the microlens-parallax and lens-orbital effects by presenting the analysis of the gravitational binary-lens event OGLE-2015-BLG-0768. Despite the obvious deviation from the model based on the linear observer motion and the static binary, it is found that the residual can be almost equally well explained by either the parallactic motion of the Earth or the rotation of the binary-lens axis, resulting in the severe degeneracy between the two effects. We show that the degeneracy can be readily resolved with the additional data provided by space-based microlens parallax observations. By enabling us to distinguish between the two higher-order effects, space-based microlens parallax observations will not only make it possible to accurately determine the physical lens parameters but also to further constrain the orbital parameters of binary lenses.

Repeated rendezvous treatment of PTBD and ERCP in patients with recurrent obstructive jaundice.

Science.gov (United States)

Liu, Yingdi; Meng, Jianyun; Wang, Jianhua; Wang, Zhiqiang; Wang, Xiangdong; Linghu, Enqiang; Li, Wen; Yang, Yunsheng

2010-01-01

Repeated applications of rendezvous technique combining percutaneous transhepatic biliary drainage (PTBD) with endoscopic retrograde cholangiopancreatography (ERCP) (PE) in patients with recurrent obstructive jaundice have not been reported. The present study aimed to evaluate treatment effects of this technique in patients who previously received the same rendezvous treatment. Repeated PE rendezvous procedure was performed in 27 patients who received the same procedure previously and had recurrent obstructive jaundice. Twenty-two patients were treated by second-time rendezvous procedure and five patients by third-time. The clinical characteristics and therapeutic effects were retrospectively analyzed. By means of repeated rendezvous technique, 26 patients gained access to the bile duct and were successfully implanted new stents, only one failed with stent implantation. Total serum bilirubin level decreased within one week from 221.89 +/- 64.70 micromol/L to 156.0 +/- 32.2 micromol/L in patients with second-time treatment and from 297.07 +/- 109.12 micromol/L to 238.77 +/- 36.81 micromol/L in patients with third-time treatment. There was no severe complications observed that are associated with repeated PE procedure. Rendezvous procedure of PTBD and ERCP could be used repeatedly and effectively for patients who present recurrent obstructive jaundice after ERCP failure.

Ground-truth aerosol lidar observations: can the Klett solutions obtained from ground and space be equal for the same aerosol case?

International Nuclear Information System (INIS)

Ansmann, Albert

2006-01-01

Upcoming multiyear satellite lidar aerosol observations need strong support by a worldwide ground-truth lidar network. In this context the question arises as to whether the ground stations can deliver the same results as obtained from space when the Klett formalism is applied to elastic backscatter lidar data for the same aerosol case. This question is investigated based on simulations of observed cases of simple and complex aerosol layering. The results show that the differences between spaceborne and ground-based observations can be as large as20% for the backscatter and extinction coefficients and the optimum estimates of the column lidar ratios. In cases with complex aerosol layering, the application of the two-layer approach can lead to similar results (space, ground) and accurate products provided that horizontally homogeneous aerosol conditions are given

Association of aromatase (TTTA)n repeat polymorphisms with central precocious puberty in girls.

Science.gov (United States)

Lee, Hae Sang; Kim, Kyung Hee; Hwang, Jin Soon

2014-09-01

Precocious puberty is characterized by early activation of the pituitary-gonadal axis. Oestrogen is the final key factor to start the onset of puberty. The cytochrome P450 19A1 (CYP19A1) gene encodes an aromatase that is responsible for the conversion of androgens to oestrogen, which is a key step in oestrogen biosynthesis. The aim of this study was to identify CYP19A1 gene mutations or polymorphisms in girls with central precocious puberty (CPP). We evaluated the frequency of allelic variants of the CYP19A1 exons and the tetranucleotide tandem repeat (TTTA)n in intron 4 in 203 idiopathic central precocious puberty (CPP) girls and 101 normal healthy women. The genotype analysis of the CYP19A1 (TTTA)n polymorphism revealed six different alleles ranging from seven to 13 repeats. Among the six different repeat alleles detected in this study, the (TTTA)₁₃ repeat allele was only detected in the patient group and carriers of the (TTTA)₁₃ allele were significantly associated with an increased risk of CPP (OR = 1·509, 95% CI = 1·425-1·598, P = 0·033). Carriers of the (TTTA)₁₃ repeat allele were significantly younger at pubertal onset and had higher levels of oestrogen than noncarriers of the (TTTA)₁₃ repeat allele. Although nine polymorphisms were detected in exons of the CYP19A1 gene, no clinical significance was observed. In this study, carriers of a higher repeat (TTTA)₁₃ polymorphism in intron 4 of the CYP19A1 gene had higher levels of oestrogen. Those carrying the (TTTA)₁₃ repeat allele may have a higher risk of developing CPP. © 2014 John Wiley & Sons Ltd.

Abortion trends from 1996 to 2011 in Estonia: special emphasis on repeat abortion

Science.gov (United States)

2014-01-01

Background The study aimed to describe the overall and age-specific trends of induced abortions from 1996 to 2011 with an emphasis on socio-demographic characteristics and contraceptive use of women having had repeat abortions in Estonia. Methods Data were retrieved from the Estonian Medical Birth and Abortion Registry and Statistics Estonia. Total induced abortion numbers, rates, ratios and age-specific rates are presented for 1996–2011. The percentage change in the number of repeat abortions within selected socio-demographic subgroups, contraception use and distribution of induced abortions among Estonians and non-Estonians for the first, second, third, fourth and subsequent abortions were calculated for the periods 1996–2003 and 2004–2011. Results Observed trends over the 16-year study period indicated a considerable decline in induced abortions with a reduction in abortion rate of 57.1%, which was mainly attributed to younger cohorts. The percentage of women undergoing repeat abortions fell steadily from 63.8% during 1996–2003 to 58.0% during 2004–2011. The percentage of women undergoing repeat abortions significantly decreased over the 16 years within all selected socio-demographic subgroups except among women with low educational attainment and students. Within each time period, a greater percentage of non-Estonians than Estonians underwent repeat abortions and obtained third and subsequent abortions. Most women did not use any contraceptive method prior to their first or subsequent abortion. Conclusion A high percentage of women obtaining repeat abortions reflects a high historical abortion rate. If current trends continue, a rapid decline in repeat abortions may be predicted. To decrease the burden of sexual ill health, routine contraceptive counselling, as standard care in the abortion process, should be seriously addressed with an emphasis on those groups - non-Estonians, women with lower educational attainment, students and women with children

Observational modeling of topological spaces

International Nuclear Information System (INIS)

Molaei, M.R.

2009-01-01

In this paper a model for a multi-dimensional observer by using of the fuzzy theory is presented. Relative form of Tychonoff theorem is proved. The notion of topological entropy is extended. The persistence of relative topological entropy under relative conjugate relation is proved.

Antipsychotic Selection for Acute Agitation and Time to Repeat Use in a Psychiatric Emergency Department.

Science.gov (United States)

Gomez, Seth; Dopheide, Julie

2016-11-01

Early recognition and treatment of agitated patients is essential to avoid violence in the psychiatric emergency department (ED). Antipsychotics have established efficacy in managing agitation, yet little is known about how the choice of initial antipsychotic impacts time to repeat use and length of stay (LOS) in the psychiatric ED. To describe the impact of initial antipsychotic selection on time to repeat use and LOS in the psychiatric ED. A chart review identified 388 cases in which patients were administered an antipsychotic for agitation in the psychiatric ED between July 1 and August 31, 2014. Time to repeat use and LOS were compared for intramuscular (IM) haloperidol, other IM antipsychotics, and oral second-generation antipsychotics (SGAs) using the Kruskal-Wallis or Wilcoxon-Mann-Whitney test. Of the 388 cases, 31% (n=122) required repeat medications. Mean time to repeat use for IM haloperidol was 20.1±18.4 hours, which was not significantly different from mean time to repeat use in the groups receiving other IM antipsychotics or oral SGAs (P=0.35). The mean LOS was 29.7±28.7 hours for IM haloperidol, 30.3±36.9 hours for other IM antipsychotics, and 22.6±28.0 hours for oral SGAs. Significant differences in LOS between repeat and nonrepeat users of IM haloperidol and other IM antipsychotics were observed, but not among those who received oral SGAs. Mean time to repeat use ranged from 14 to 20 hours with IM haloperidol, other IM antipsychotics, and oral SGAs without significant differences in time to repeat use in the 3 different groups. Repeat users of IM antipsychotics had a significantly longer LOS in the ED compared with nonrepeat users of IM antipsychotics. However, patients who were initially administered oral SGAs did not have longer LOS in the ED even if a repeat dose was given.

Hubble Space Telescope STIS observations of GRB 000301C: CCD imaging and near-ultraviolet MAMA spectroscopy

DEFF Research Database (Denmark)

Smette, A.; Fruchter, A.S.; Gull, T.R.

2001-01-01

We present Space Telescope Imaging Spectrograph observations of the optical transient (OT) counterpart of the c-ray burster GRB 000301C obtained 5 days after the burst, on 2000 March 6. CCD clear-aperture imaging reveals a R similar or equal to 21.50 +/- 0.15 source with no apparent host galaxy...... Telescope images appear to lie on the stellar field of a host galaxy, and as the large H I column density measured here and in later ground-based observations is unlikely on a random line of sight, we believe we are probably seeing absorption from H I in the host galaxy. In any case, this represents...

Skylab experiments. Volume 5: Astronomy and space physics. [Skylab observations of galactic radiation, solar energy, and interplanetary composition for high school level education

Science.gov (United States)

1973-01-01

The astronomy and space physics investigations conducted in the Skylab program include over 20 experiments in four categories to explore space phenomena that cannot be observed from earth. The categories of space research are as follows: (1) phenomena within the solar system, such as the effect of solar energy on Earth's atmosphere, the composition of interplanetary space, the possibility of an inner planet, and the X-ray radiation from Jupiter, (2) analysis of energetic particles such as cosmic rays and neutrons in the near-earth space, (3) stellar and galactic astronomy, and (4) self-induced environment surrounding the Skylab spacecraft.

Repeatability of the three dimensional kinematics of the pelvis, spine and lower limbs while performing selected exercises

Directory of Open Access Journals (Sweden)

Skublewska-Paszkowska Maria

2017-01-01

Full Text Available Three-dimensional optical systems are used for calculating many kinetic and kinematic parameters. The obtained data are precise; however, their repeatability is a very important aspect. The aim of this paper is to verify the range of motion repeatability of one healthy subject in the joints of the pelvis, spine and lower limbs based on the coefficient of variation. The participant performed seven exercises, repeated five times: two-leg squat, single-leg squat, forward bending, forward-step motion, step onto the stair, hip extension in a standing position and tip-toe extension while standing. Motion was recorded using Vicon motion capture system consisting of eight NIR cameras. The participant had 39 markers attached to her body according to the Plug-in Gait model. The coefficient of variation was calculated in three dimensions (X, Y and Z. The greatest repeatability, pursuant to the coefficient, was observed during the two-leg squat and forward bending in the sagittal plane (X coordinate. It was also high during the single-leg squat. The lowest repeatability was observed during the tip-toe extension while standing and the hip extension in a standing position. During the step onto the stair and the forward-step motion, a higher repeatability of measurement occurred in the open kinematic chain than in the closed chain; in the hip extension the reverse occurred. Repeatability of a range of motion is different in two types of kinematic chain and in 7 exercises. Exercises such as tip-toe extension and hip extension, which require a greater ability to balance, indicated more variability in movement.

Results of the Simulation and Assimilation of Doppler Wind Lidar Observations in Preparation for European Space Agency's Aeolus Mission

Science.gov (United States)

McCarty, Will

2011-01-01

With the launch of the European Space Agency's Aeolus Mission in 2013, direct spaceborne measurements of vertical wind profiles are imminent via Doppler wind lidar technology. Part of the preparedness for such missions is the development of the proper data assimilation methodology for handling such observations. Since no heritage measurements exist in space, the Joint Observing System Simulation Experiment (Joint OSSE) framework has been utilized to generate a realistic proxy dataset as a precursor to flight. These data are being used for the development of the Gridpoint Statistical Interpolation (GSI) data assimilation system utilized at a number of centers through the United States including the Global Modeling and Assimilation Office (GMAO) at NASA/Goddard Space Flight Center and at the National Centers for Environmental Prediction (NOAA/NWS/NCEP) as an activity through the Joint Center for Satellite Data Assimilation. An update of this ongoing effort will be presented, including the methodology of proxy data generation, the limitations of the proxy data, the handling of line-of-sight wind measurements within the GSI, and the impact on both analyses and forecasts with the addition of the new data type.

The James Webb Space Telescope's Plan for Operations and Instrument Capabilities for Observations in the Solar System

Science.gov (United States)

Milam, Stefanie N.; Stansberry, John A.; Sonneborn, George; Thomas, Cristina

2016-01-01

The James Webb Space Telescope (JWST) is optimized for observations in the near- and mid-infrared and will provide essential observations for targets that cannot be conducted from the ground or other missions during its lifetime. The state-of-the-art science instruments, along with the telescope's moving target tracking, will enable the infrared study, with unprecedented detail, for nearly every object (Mars and beyond) in the Solar System. The goals of this special issue are to stimulate discussion and encourage participation in JWST planning among members of the planetary science community. Key science goals for various targets, observing capabilities for JWST, and highlights for the complementary nature with other missions/observatories are described in this paper.

In situ detection of tandem DNA repeat length

Energy Technology Data Exchange (ETDEWEB)

Yaar, R.; Szafranski, P.; Cantor, C.R.; Smith, C.L. [Boston Univ., MA (United States)

1996-11-01

A simple method for scoring short tandem DNA repeats is presented. An oligonucleotide target, containing tandem repeats embedded in a unique sequence, was hybridized to a set of complementary probes, containing tandem repeats of known lengths. Single-stranded loop structures formed on duplexes containing a mismatched (different) number of tandem repeats. No loop structure formed on duplexes containing a matched (identical) number of tandem repeats. The matched and mismatched loop structures were enzymatically distinguished and differentially labeled by treatment with S1 nuclease and the Klenow fragment of DNA polymerase. 7 refs., 4 figs.

Protective Effect of Extract of Folium Ginkgo on Repeated Cerebral Ischemia-Reperfusion Injury

Institute of Scientific and Technical Information of China (English)

无

2000-01-01

Objective: To study the protective effect of extract of Folium Ginkgo (FGE) on repeated cerebral ischemia-reperfusion injury. Methods: The model in waking mice induced by repeated cerebral ischemia-reperfusion were used in the experiment to observe the effect of FGE on behavior, oxygen free radical metabolism and prostaglandin E2 (PGE2) content by step-through experiment, diving stand and colorimetric method. Results: FGE could obviously improve the learning ability and memory of model animals, and could lower obviously the content of malonyldialdehyde, nitric oxide and PGE2, restore the lowered activity of superoxide dismutase and catalase in cerebral tissue. Conclusion: FGE has highly protective effect against repeated ischemia-reperfusion injury, the mechanism might be related with its action on anti-lipid oxidatin, improve the activity of antioxidase and inhibit the producing of PGE2.

Adaptation and complexity in repeated games

DEFF Research Database (Denmark)

Maenner, Eliot Alexander

2008-01-01

The paper presents a learning model for two-player infinitely repeated games. In an inference step players construct minimally complex inferences of strategies based on observed play, and in an adaptation step players choose minimally complex best responses to an inference. When players randomly...... select an inference from a probability distribution with full support the set of steady states is a subset of the set of Nash equilibria in which only stage game Nash equilibria are played. When players make ‘cautious' inferences the set of steady states is the subset of self-confirming equilibria...... with Nash outcome paths. When players use different inference rules, the set of steady states can lie between the previous two cases...

Tandemly repeated sequence in 5'end of mtDNA control region of ...

African Journals Online (AJOL)

Extensive length variability was observed in 5' end sequence of the mitochondrial DNA control region of the Japanese Spanish mackerel (Scomberomorus niphonius). This length variability was due to the presence of varying numbers of a 56-bp tandemly repeated sequence and a 46-bp insertion/deletion (indel).

Receptionist input to quality and safety in repeat prescribing in UK general practice: ethnographic case study.

Science.gov (United States)

Swinglehurst, Deborah; Greenhalgh, Trisha; Russell, Jill; Myall, Michelle

2011-11-03

To describe, explore, and compare organisational routines for repeat prescribing in general practice to identify contributors and barriers to safety and quality. Ethnographic case study. Four urban UK general practices with diverse organisational characteristics using electronic patient records that supported semi-automation of repeat prescribing. 395 hours of ethnographic observation of staff (25 doctors, 16 nurses, 4 healthcare assistants, 6 managers, and 56 reception or administrative staff), and 28 documents and other artefacts relating to repeat prescribing locally and nationally. Potential threats to patient safety and characteristics of good practice. Observation of how doctors, receptionists, and other administrative staff contributed to, and collaborated on, the repeat prescribing routine. Analysis included mapping prescribing routines, building a rich description of organisational practices, and drawing these together through narrative synthesis. This was informed by a sociological model of how organisational routines shape and are shaped by information and communications technologies. Results Repeat prescribing was a complex, technology-supported social practice requiring collaboration between clinical and administrative staff, with important implications for patient safety. More than half of requests for repeat prescriptions were classed as "exceptions" by receptionists (most commonly because the drug, dose, or timing differed from what was on the electronic repeat list). They managed these exceptions by making situated judgments that enabled them (sometimes but not always) to bridge the gap between the idealised assumptions about tasks, roles, and interactions that were built into the electronic patient record and formal protocols, and the actual repeat prescribing routine as it played out in practice. This work was creative and demanded both explicit and tacit knowledge. Clinicians were often unaware of this input and it did not feature in policy

Repeating hemorrhage after radiotherapy for glioma. Radiological and histological observations

Energy Technology Data Exchange (ETDEWEB)

Kawano, Hirokazu [Miyakonojo Medical Association Hospital, Miyazaki (Japan); Wakisaka, Shinichiro; Kubota, Toshihiko; Hosotani, Kazuo

1998-02-01

A case of radiation necrosis which was observed six years after radiotherapy for a glioma in the right parietal lobe is reported. This patient developed hemiparesis, and radiological examinations showed similar findings consisted with recurrent glioma. Histological examination disclosed that the lesion is correspond to the radiation necrosis. (author)

Infrared Free Space Communication - The Autonomous Testing of Free Space Infrared Communication

Science.gov (United States)

Heldman, Christopher

2017-01-01

Fiber optics has been a winning player in the game of high-speed communication and data transfer in cable connections. Yet, in free space RF has been the repeated choice of communication medium of the space industry. Investigating the benefits of free space optical communication over radio frequency is worthwhile. An increase in science data rate return capabilities could occur if optical communication is implemented. Optical communication systems also provide efficiencies in power, mass, and volume over RF systems1. Optical communication systems have been demonstrated from a satellite in orbit with the moon to earth, and resulted in the highest data rates ever seen through space (622Mbps)2. Because of these benefits, optical communication is far superior to RF. The HiDRA (High Data Rate Architecture) project is researching Passive Misalignment Mitigation of Dynamic Free Apace Optical Communication Links. The goal of this effort is to enable gigabit per second transmission of data in short range dynamic links (less than 100 meters). In practice this would enhance data rates between sites on the International Space Station with minimal size, weight, and power requirements. This paper will focus on an autonomous code and a hardware setup that will be used to fulfill the next step in the research being conducted. The free space optical communications pointing downfalls will be investigated. This was achieved by creating 5 python programs and a top-level code to automate this test.

Repeat film analysis and its implications for quality assurance in dental radiology: An institutional case study

Directory of Open Access Journals (Sweden)

Shruthi Acharya

2015-01-01

Full Text Available Context: The goal of any radiologist is to produce the highest quality diagnostic radiographs, while keeping patient exposure as low as reasonably achievable (ALARA. Aims: The aim of this study was to describe the reasons for radiograph rejections through a repeat film analysis in an Indian dental school. Settings and Design: An observational study conducted in the Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal. Materials and Methods: During a 6-month study period, a total of 9,495 intra-oral radiographs and 2339 extraoral radiographs taken in the Radiology Department were subjected to repeat film analysis. Statistical Analysis Used: SPSS Version 16. Descriptive analysis used. Results: The results showed that the repeat rates were 7.1% and 5.86% for intraoral and extraoral radiographs, respectively. Among the causes for errors reported, positioning error (38.7% was the most common, followed by improper angulations (26.1%, and improper film placement (11.2% for intra-oral radiographs. The study found that the maximum frequency of repeats among extraoral radiographs was for panoramic radiographs (49% followed by lateral cephalogram (33%, and paranasal sinus view (14%. It was also observed that repeat rate of intraoral radiographs was highest for internees (44.7%, and undergraduate students (28.2%. Conclusions: The study pointed to a need for more targeted interventions to achieve the goal of keeping patient exposure ALARA in a dental school setting.

Negative differential mobility for negative carriers as revealed by space charge measurements on crosslinked polyethylene insulated model cables

International Nuclear Information System (INIS)

Teyssedre, G.; Laurent, C.; Vu, T. T. N.

2015-01-01

Among features observed in polyethylene materials under relatively high field, space charge packets, consisting in a pulse of net charge that remains in the form of a pulse as it crosses the insulation, are repeatedly observed but without complete theory explaining their formation and propagation. Positive charge packets are more often reported, and the models based on negative differential mobility(NDM) for the transport of holes could account for some charge packets phenomenology. Conversely, NDM for electrons transport has never been reported so far. The present contribution reports space charge measurements by pulsed electroacoustic method on miniature cables that are model of HVDC cables. The measurements were realized at room temperature or with a temperature gradient of 10 °C through the insulation under DC fields on the order 30–60 kV/mm. Space charge results reveal systematic occurrence of a negative front of charges generated at the inner electrode that moves toward the outer electrode at the beginning of the polarization step. It is observed that the transit time of the front of negative charge increases, and therefore the mobility decreases, with the applied voltage. Further, the estimated mobility, in the range 10 −14 –10 −13  m 2  V −1  s −1 for the present results, increases when the temperature increases for the same condition of applied voltage. The features substantiate the hypothesis of negative differential mobility used for modelling space charge packets

Negative differential mobility for negative carriers as revealed by space charge measurements on crosslinked polyethylene insulated model cables

Science.gov (United States)

Teyssedre, G.; Vu, T. T. N.; Laurent, C.

2015-12-01

Among features observed in polyethylene materials under relatively high field, space charge packets, consisting in a pulse of net charge that remains in the form of a pulse as it crosses the insulation, are repeatedly observed but without complete theory explaining their formation and propagation. Positive charge packets are more often reported, and the models based on negative differential mobility(NDM) for the transport of holes could account for some charge packets phenomenology. Conversely, NDM for electrons transport has never been reported so far. The present contribution reports space charge measurements by pulsed electroacoustic method on miniature cables that are model of HVDC cables. The measurements were realized at room temperature or with a temperature gradient of 10 °C through the insulation under DC fields on the order 30-60 kV/mm. Space charge results reveal systematic occurrence of a negative front of charges generated at the inner electrode that moves toward the outer electrode at the beginning of the polarization step. It is observed that the transit time of the front of negative charge increases, and therefore the mobility decreases, with the applied voltage. Further, the estimated mobility, in the range 10-14-10-13 m2 V-1 s-1 for the present results, increases when the temperature increases for the same condition of applied voltage. The features substantiate the hypothesis of negative differential mobility used for modelling space charge packets.

The effect of pre-mutation of X chromosome CGG trinucleotide repeats on brain anatomy.

Science.gov (United States)

Moore, Caroline J; Daly, Eileen M; Tassone, Flora; Tysoe, Carolyn; Schmitz, Nicole; Ng, Virginia; Chitnis, Xavier; McGuire, Philip; Suckling, John; Davies, Kay E; Hagerman, Randi J; Hagerman, Paul J; Murphy, Kieran C; Murphy, Declan G M

2004-12-01

Expanded trinucleotide repeats are associated with several neuropsychiatric disorders, including fragile X syndrome (FraX) which is the most common inherited form of mental retardation. It is currently thought that FraX results from having >200 CGG trinucleotide repeats, with consequent methylation of the fragile X mental retardation gene (FMR1) and loss of FMR1 protein (FMRP). Pre-mutation carriers of FraX (with 55-200 CGG trinucleotide repeats) were originally considered unaffected, although recent studies challenge this view. However, there are few studies on the effect of pre-mutation trinucleotide repeat expansion on the male human brain using quantitative MRI. Also the results of prior investigations may be confounded because people were selected on the basis of clinical and neurological features, and not genetic phenotype. We compared the brain anatomy of 20 adult male pre-mutation members of known FraX families with 20 healthy male controls. The two groups did not differ significantly in age, intelligence quotient (IQ) or handedness. We also investigated whether any observed effects were associated with: (i) ageing; (ii) expansion of pre-mutation CGG trinucleotide repeats; (iii) reduction in the percentage of lymphocytes staining with anti-FMRP antibodies [%FMRP(+) lymphocytes]; and (iv) elevation of FMR1 mRNA levels. Male pre-mutation carriers of FraX, compared with matched controls, had significantly less voxel density in several brain regions, including the cerebellum, amygdalo-hippocampal complex and thalamus. Within pre-mutation carriers of FraX, ageing, increases in the number of CGG trinucleotide repeats and decreases in %FMRP(+) lymphocytes were associated with decreasing voxel density of regions previously identified as decreased relative to controls. Regional grey and white matter density is significantly affected in male pre-mutation carriers of FraX recruited on the basis of genetic, not clinical, phenotype. The association of voxel density

OGLE-2015-BLG-0479LA,B: BINARY GRAVITATIONAL MICROLENS CHARACTERIZED BY SIMULTANEOUS GROUND-BASED AND SPACE-BASED OBSERVATIONS

Energy Technology Data Exchange (ETDEWEB)

Han, C. [Department of Physics, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Udalski, A.; Szymański, M. K.; Soszyński, I.; Skowron, J.; Mróz, P.; Poleski, R. [Warsaw University Observatory, Al. Ujazdowskie 4, 00-478 Warszawa (Poland); Gould, A.; Zhu, Wei; Fausnaugh, M.; Gaudi, B. S.; Wibking, B. [Department of Astronomy, Ohio State University, 140 W. 18th Avenue, Columbus, OH 43210 (United States); Street, R. A. [School of Physics and Astronomy, Queen Mary University of London, Mile End Road, London E1 4NS (United Kingdom); Yee, J. C. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Beichman, C.; Novati, S. Calchi [NASA Exoplanet Science Institute, MS 100-22, California Institute of Technology, Pasadena, CA 91125 (United States); Bryden, C.; Henderson, Calen B.; Shvartzvald, Y. [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Carey, S. [Spitzer Science Center, MS 220-6, California Institute of Technology, Pasadena, CA (United States); Collaboration: (The Spitzer Microlensing Team; (The OGLE Collaboration; (The RoboNet collaboration; (The MiNDSTEp Consortium; (The μ FUN Collaboration; and others

2016-09-01

We present a combined analysis of the observations of the gravitational microlensing event OGLE-2015-BLG-0479 taken both from the ground and by the Spitzer Space Telescope . The light curves seen from the ground and from space exhibit a time offset of ∼13 days between the caustic spikes, indicating that the relative lens-source positions seen from the two places are displaced by parallax effects. From modeling the light curves, we measure the space-based microlens parallax. Combined with the angular Einstein radius measured by analyzing the caustic crossings, we determine the mass and distance of the lens. We find that the lens is a binary composed of two G-type stars with masses of ∼1.0 M {sub ⊙} and ∼0.9 M {sub ⊙} located at a distance of ∼3 kpc. In addition, we are able to constrain the complete orbital parameters of the lens thanks to the precise measurement of the microlens parallax derived from the joint analysis. In contrast to the binary event OGLE-2014-BLG-1050, which was also observed by Spitzer, we find that the interpretation of OGLE-2015-BLG-0479 does not suffer from the degeneracy between (±, ±) and (±, ∓) solutions, confirming that the four-fold parallax degeneracy in single-lens events collapses into the two-fold degeneracy for the general case of binary-lens events. The location of the blend in the color–magnitude diagram is consistent with the lens properties, suggesting that the blend is the lens itself. The blend is bright enough for spectroscopy and thus this possibility can be checked from future follow-up observations.

Changes of hormones regulating electrolyte metabolism after space flight and hypokinesia

Science.gov (United States)

Macho, L.; Fickova, M.; Lichardus, B.; Kvetnansky, R.; Carrey, R. M.; Grigoriev, A.; Popova, I. A.; Tigranian, R. A.; Noskov, V. B.

The changes of hormones in plasma involved in the body fluid regulation were studied in human subjects during and after space flights in relation to redistribution of body fluids in the state of weightlessness. Since hypokinesia was used as a model for simulation of some effects of the stay in microgravity the plasma hormone levels in rats exposed to hypokinesia were also investigated. Plasma aldosterone values showed great individual variations during the first inflight days, the increased levels were observed with prolongation of space flights. The important elevation was found in the recovery period, however it was interesting to note, that in some cosmonauts with repeated exposure to space flight, the postflight plasma aldosterone levels were not elevated. The urine excretion of aldosterone was increased inflight, however in postflight period the decrease or increase were found in the first 1-5 days. The increase of plasma renin activity was observed in flight and postflight period. The rats were exposed to hypokinesia (forced restriction of motor activity) for 1, 7 and 60 days and urine was collected during last 24 hours. The animals were sacrificed and the concentration of electrolytes and of levels of corticosterone aldosteron (A), ANF and plasma-renin activity (PRA) were determined in plasma. In urine excretion of sodium and potassium were estimated. An important increase of plasma renin activity and aldosterone concentration was found after short-term hypokinesia (1 day). These hormonal values appear to decrease with time (7 days) and are not significantly different from controls after long-term hypokinesia (60 days). A decrease of values ANF in plasma was observed after 1 and 7 days hypokinesia. After prolonged hypokinesia a decrease of sodium plasma concentration was observed. The excretion of sodium in urine was higher in long-term hypokinetic animals. There were no significant changes of plasma potassium levels in rats exposed to hypokinesia, however

A Decision Support Framework for Feasibility Analysis of International Space Station (ISS) Research Capability Enhancing Options

Science.gov (United States)

Ortiz, James N.; Scott,Kelly; Smith, Harold

2004-01-01

The assembly and operation of the ISS has generated significant challenges that have ultimately impacted resources available to the program's primary mission: research. To address this, program personnel routinely perform trade-off studies on alternative options to enhance research. The approach, content level of analysis and resulting outputs of these studies vary due to many factors, however, complicating the Program Manager's job of selecting the best option. To address this, the program requested a framework be developed to evaluate multiple research-enhancing options in a thorough, disciplined and repeatable manner, and to identify the best option on the basis of cost, benefit and risk. The resulting framework consisted of a systematic methodology and a decision-support toolset. The framework provides quantifiable and repeatable means for ranking research-enhancing options for the complex and multiple-constraint domain of the space research laboratory. This paper describes the development, verification and validation of this framework and provides observations on its operational use.

Factors Associated with Preference for Repeat Cesarean in Neyshabur Pregnant Women

Directory of Open Access Journals (Sweden)

Ali Gholami

2014-01-01

Conclusions: As observed in this study, most pregnant women with previous caesarean delivery prefer repeated caesarean delivery rather than VD in their subsequent pregnancy and educational level of pregnant women and doctor′s advice were important factors that influenced this preference. This subject suggests the need to counsel pregnant women with an obstetrician before select delivery type.

Multi-Repeated Projection Lithography for High-Precision Linear Scale Based on Average Homogenization Effect

Directory of Open Access Journals (Sweden)

Dongxu Ren

2016-04-01

Full Text Available A multi-repeated photolithography method for manufacturing an incremental linear scale using projection lithography is presented. The method is based on the average homogenization effect that periodically superposes the light intensity of different locations of pitches in the mask to make a consistent energy distribution at a specific wavelength, from which the accuracy of a linear scale can be improved precisely using the average pitch with different step distances. The method’s theoretical error is within 0.01 µm for a periodic mask with a 2-µm sine-wave error. The intensity error models in the focal plane include the rectangular grating error on the mask, static positioning error, and lithography lens focal plane alignment error, which affect pitch uniformity less than in the common linear scale projection lithography splicing process. It was analyzed and confirmed that increasing the repeat exposure number of a single stripe could improve accuracy, as could adjusting the exposure spacing to achieve a set proportion of black and white stripes. According to the experimental results, the effectiveness of the multi-repeated photolithography method is confirmed to easily realize a pitch accuracy of 43 nm in any 10 locations of 1 m, and the whole length accuracy of the linear scale is less than 1 µm/m.

Digital repeat analysis; setup and operation.

Science.gov (United States)

Nol, J; Isouard, G; Mirecki, J

2006-06-01

Since the emergence of digital imaging, there have been questions about the necessity of continuing reject analysis programs in imaging departments to evaluate performance and quality. As a marketing strategy, most suppliers of digital technology focus on the supremacy of the technology and its ability to reduce the number of repeats, resulting in less radiation doses given to patients and increased productivity in the department. On the other hand, quality assurance radiographers and radiologists believe that repeats are mainly related to positioning skills, and repeat analysis is the main tool to plan training needs to up-skill radiographers. A comparative study between conventional and digital imaging was undertaken to compare outcomes and evaluate the need for reject analysis. However, digital technology still being at its early development stages, setting a credible reject analysis program became the major task of the study. It took the department, with the help of the suppliers of the computed radiography reader and the picture archiving and communication system, over 2 years of software enhancement to build a reliable digital repeat analysis system. The results were supportive of both philosophies; the number of repeats as a result of exposure factors was reduced dramatically; however, the percentage of repeats as a result of positioning skills was slightly on the increase for the simple reason that some rejects in the conventional system qualifying for both exposure and positioning errors were classified as exposure error. The ability of digitally adjusting dark or light images reclassified some of those images as positioning errors.

Microsatellite instability at a tetranucleotide repeat in type I endometrial carcinoma

Directory of Open Access Journals (Sweden)

Choi Ho

2008-12-01

Full Text Available Abstract Background Microsatellite instability (MSI at tri- or tetranucleotide repeat markers (elevated microsatellite alterations at selected tetranucleotide repeat, EMAST has been recently described. But, the underlying genetic mechanism of EMAST is unclear. This study was to investigate the prevalence of EMAST, in type I endometrial carcinoma, and to determine the correlation between the MSI status and mismatch repair genes (MMR or p53. Methods We examined the 3 mono-, 3 di-, and 6 tetranucleotide repeat markers by PCR in 39 cases of type I endometrial carcinoma and performed the immunohistochemistry of hMSH2, hMLH1, and p53 protein. Results More than two MSI at mono- and dinucleotide repeat markers was noted in 8 cases (MSI-H, 20.5%. MSI, at a tetranucleotide repeat, was detected in 15 cases (EMAST, 38.5%. In remaining 16 cases, any MSI was not observed. (MSS, 42.1%, MSI status was not associated with FIGO stage, grade or depth of invasion. The absence of expression of either one of both hMSH2 or hMLH1 was noted in seven (87.5% of eight MSI-H tumors, one (6.3% of 16 MSS tumors, and five (33.3% of 15 EMAST tumors. (p = 0.010 The expression of p53 protein was found in one (12.5% of eight MSI-H tumors, five (31.3% of 16 MSS tumors, and seven of 15 EMAST tumors. (p = 0.247 Conclusion Our results showed that about 38.5% of type I endometrial carcinomas exhibited EMAST, and that EMAST was rarely associated with alteration of hMSH2 or hMLH1.

Origins Space Telescope: Breaking the Confusion Limit

Science.gov (United States)

Wright, Edward L.; Origins Space Telescope Science and Technology Definition Team

2018-01-01

The Origins Space Telescope (OST) is the mission concept for the Far-Infrared Surveyor, one of the four science and technology definition studies of NASA Headquarters for the 2020 Astronomy and Astrophysics Decadal survey. Origins will enable flagship-quality general observing programs led by the astronomical community in the 2030s.OST will have a background-limited sensitivity for a background 27,000 times lower than the Herschel background caused by thermal emission from Herschel's warm telescope. For continuum observations the confusion limit in a diffraction-limited survey can be reached in very short integration times at longer far-infrared wavelengths. But the confusion limit can be pierced for both the nearest and the farthest objects to be observed by OST. For outer the Solar System the targets' motion across the sky will provide a clear signature in surveys repeated after an interval of days to months. This will provide a size-frequency distribution of TNOs that is not biased toward high albedo objects.For the distant Universe the first galaxies and the first metals will provide a third dimension of spectral information that can be measured with a long-slit, medium resolution spectrograph. This will allow 3Dmapping to measure source densities as a function of redshift. The continuum shape associated with sourcesat different redshifts can be derived from correlation analyses of these 3D maps.Fairly large sky areas can be scanned by moving the spacecraft at a constant angular rate perpendicular to the orientation of the long slit of the spectrograph, avoiding the high overhead of step-and-stare surveying with a large space observatory.We welcome you to contact the Science and Technology Definition Team (STDT) with your science needs and ideas by emailing us at ost_info@lists.ipac.caltech.edu

Low numbers of repeat units in variable number of tandem repeats (VNTR) regions of white spot syndrome virus are correlated with disease outbreaks.

Science.gov (United States)

Hoa, T T T; Zwart, M P; Phuong, N T; de Jong, M C M; Vlak, J M

2012-11-01

White spot syndrome virus (WSSV) is the most important pathogen in shrimp farming systems worldwide including the Mekong Delta, Vietnam. The genome of WSSV is characterized by the presence of two major 'indel regions' found at ORF14/15 and ORF23/24 (WSSV-Thailand) and three regions with variable number tandem repeats (VNTR) located in ORF75, ORF94 and ORF125. In the current study, we investigated whether or not the number of repeat units in the VNTRs correlates with virus outbreak status and/or shrimp farming practice. We analysed 662 WSSV samples from individual WSSV-infected Penaeus monodon shrimp from 104 ponds collected from two important shrimp farming regions of the Mekong Delta: Ca Mau and Bac Lieu. Using this large data set and statistical analysis, we found that for ORF94 and ORF125, the mean number of repeat units (RUs) in VNTRs was significantly lower in disease outbreak ponds than in non-outbreak ponds. Although a higher mean RU number was observed in the improved-extensive system than in the rice-shrimp or semi-intensive systems, these differences were not significant. VNTR sequences are thus not only useful markers for studying WSSV genotypes and populations, but specific VNTR variants also correlate with disease outbreaks in shrimp farming systems. © 2012 Blackwell Publishing Ltd.

Coexistence of 3G repeaters with LTE base stations.

Science.gov (United States)

Yeo, Woon-Young; Lee, Sang-Min; Hwang, Gyung-Ho; Kim, Jae-Hoon

2013-01-01

Repeaters have been an attractive solution for mobile operators to upgrade their wireless networks at low cost and to extend network coverage effectively. Since the first LTE commercial deployment in 2009, many mobile operators have launched LTE networks by upgrading their 3G and legacy networks. Because all 3G frequency bands are shared with the frequency bands for LTE deployment and 3G mobile operators have an enormous number of repeaters, reusing 3G repeaters in LTE networks is definitely a practical and cost-efficient solution. However, 3G repeaters usually do not support spatial multiplexing with multiple antennas, and thus it is difficult to reuse them directly in LTE networks. In order to support spatial multiplexing of LTE, the role of 3G repeaters should be replaced with small LTE base stations or MIMO-capable repeaters. In this paper, a repeater network is proposed to reuse 3G repeaters in LTE deployment while still supporting multilayer transmission of LTE. Interestingly, the proposed network has a higher cluster throughput than an LTE network with MIMO-capable repeaters.

Repeatability & Workability Evaluation of SIGMOD 2009

KAUST Repository

Manegold, Stefan

2010-12-15

SIGMOD 2008 was the first database conference that offered to test submitters\\' programs against their data to verify the repeatability of the experiments published [1]. Given the positive feedback concerning the SIGMOD 2008 repeatability initiative, SIGMOD 2009 modified and expanded the initiative with a workability assessment.

Repeatability & Workability Evaluation of SIGMOD 2009

KAUST Repository

Manegold, Stefan; Manolescu, Ioana; Afanasiev, Loredana; Feng, Jieling; Gou, G.; Hadjieleftheriou, Marios; Harizopoulos, Stavros; Kalnis, Panos; Karanasos, Konstantinos; Laurent, Dominique; Lupu, M.; Onose, N.; Ré , C.; Sans, Virginie; Senellart, Pierre; Wu, T.; Shasha, Dennis E.

2010-01-01

SIGMOD 2008 was the first database conference that offered to test submitters' programs against their data to verify the repeatability of the experiments published [1]. Given the positive feedback concerning the SIGMOD 2008 repeatability initiative, SIGMOD 2009 modified and expanded the initiative with a workability assessment.

The effect of stimulation interval on plasticity following repeated blocks of intermittent theta burst stimulation.

Science.gov (United States)

Tse, Nga Yan; Goldsworthy, Mitchell R; Ridding, Michael C; Coxon, James P; Fitzgerald, Paul B; Fornito, Alex; Rogasch, Nigel C

2018-06-04

This study assessed the effect of interval duration on the direction and magnitude of changes in cortical excitability and inhibition when applying repeated blocks of intermittent theta burst stimulation (iTBS) over motor cortex. 15 participants received three different iTBS conditions on separate days: single iTBS; repeated iTBS with a 5 minute interval (iTBS-5-iTBS); and with a 15 minute interval (iTBS-15-iTBS). Changes in cortical excitability and short-interval cortical inhibition (SICI) were assessed via motor-evoked potentials (MEPs) before and up to 60 mins following stimulation. iTBS-15-iTBS increased MEP amplitude for up to 60 mins post stimulation, whereas iTBS-5-iTBS decreased MEP amplitude. In contrast, MEP amplitude was not altered by single iTBS. Despite the group level findings, only 53% of individuals showed facilitated MEPs following iTBS-15-iTBS, and only 40% inhibited MEPs following iTBS-5-iTBS. Modulation of SICI did not differ between conditions. These results suggest interval duration between spaced iTBS plays an important role in determining the direction of plasticity on excitatory, but not inhibitory circuits in human motor cortex. While repeated iTBS can increase the magnitude of MEP facilitation/inhibition in some individuals compared to single iTBS, the response to repeated iTBS appears variable between individuals in this small sample.

Acquiring a cognitive skill with a new repeating version of the Tower of London task.

Science.gov (United States)

Ouellet, Marie-Christine; Beauchamp, Miriam H; Owen, Adrian M; Doyon, Julien

2004-12-01

A computerized version of the Tower of London task was used to investigate cognitive skill learning. Thirty-six healthy volunteers were assigned to either a random condition (nonrecurring problems), or to a sequence condition in which, unbeknownst to the subjects, a repeating sequence of three problems was presented. Indices of execution, planning, and total time, as well as number of moves performed, were used to measure behavioural change. Subjects' performance improved in both conditions across blocks of practice. A distinct learning effect related to the repeating sequence was also observed. This suggests that a specific skill that reflects procedural learning of the strategies, rules, and procedures pertaining to repeating problems can develop over and above a more general skill at solving cognitive planning problems with practice.

Factors influencing repeated teenage pregnancy: a review and meta-analysis.

Science.gov (United States)

Maravilla, Joemer C; Betts, Kim S; Couto E Cruz, Camila; Alati, Rosa

2017-11-01

Existing evidence of predictors of repeated teenage pregnancy has not been assessed rigorously. This systematic review provides a comprehensive evaluation of protective and risk factors that are associated with repeated teenage pregnancy through a metaanalytical consensus. We used PubMed, EMBASE, CINAHL, ProQuest, PsychINFO, ScienceDirect, Scopus, and Web of Science databases from 1997-2015 and the reference list of other relevant research papers and related reviews. Eligibility criteria included (1) epidemiologic studies that analyzed factors associated with repeated pregnancy or birth among adolescents pregnancy, and (2) experimental studies with an observational component that was adjusted for the intervention. We performed narrative synthesis of study characteristics, participant characteristics, study results, and quality assessment. We also conducted random-effects and quality-effects metaanalyses with meta-regression to obtain pooled odds ratios of identified factors and to determine sources of between-study heterogeneity. Twenty-six eligible epidemiologic studies, most from the United States (n=24), showed >47 factors with no evidence of publication bias for each metaanalysis. Use of contraception (pooled odds ratio, 0.60; 95% confidence interval, 0.35-1.02), particularly long-acting reversible contraceptives (pooled odds ratio, 0.19; 95% confidence interval, 0.08-0.45), considerably reduced repeated teenage pregnancy risk. Among studies about contraception, the number of follow-up visits (adjusted coefficient, 0.72; P=.102) and country of study (unadjusted coefficient, 2.57; permuted P=.071) explained between-study heterogeneity. Education-related factors, which included higher level of education (pooled odds ratio, 0.74; 95% confidence interval, 0.60-0.91) and school continuation (pooled odds ratio, 0.53; 95% confidence interval, 0.33-0.84), were found to be protective. Conversely, depression (pooled odds ratio, 1.46; 95% confidence interval, 1

Impact of the 'Providing Access to Continued Education' Programme on Repeat Teenage Pregnancy in the Bahamas.

Science.gov (United States)

Sakharkar, V P; Frankson, M A; Sakharkar, P R

2015-05-15

To determine the relationship of determinants such as age, ethnicity, education and sexual behaviour with repeat teenage pregnancy and to determine the impact of 'Providing Access to Continued Education' (PACE) programme in reducing repeat teenage pregnancy amongst its participants in The Bahamas. This retrospective cohort study included 397 attendees of the Adolescent Health Centre (AHC). Eighty-eight out of 139 registered participants completed the PACE programme. Data on age, ethnicity, education, sexual behaviour and repeat pregnancy in two years were analysed for descriptive statistics, and association of demographic characteristics and participation in the PACE programme with repeat pregnancy using the Chi-squared test. Mean age of participants was 16.4 ± 1.1 years; median school grade and mean grade point average (GPA) was 11 and 1.97 ± 0.7, respectively. The mean age at the first sexual activity was 14.9 ± 1.2 years. The mean age and number of sexual partners were 21 ± 4.3 years and 2 ± 1, respectively. Overall, repeat pregnancy rate was 39%: 37.4% amongst PACE registered and 31.8% amongst PACE completed mothers. No significant difference was observed in repeat pregnancy between registered and non-registered as well as those who completed the programme and those who did not. The odds ratio of 0.525 suggested that completion of the PACE programme had a moderate protective effect on reducing repeat pregnancy. Age, ethnicity, education and sexual behaviour showed no association with repeat pregnancy. The PACE programme did not reduce repeat pregnancy rate significantly. However, completion of the programme offered a moderate protection.

Changes in Variable Number of Tandem Repeats in 'Candidatus Liberibacter asiaticus' through Insect Transmission.

Directory of Open Access Journals (Sweden)

Hiroshi Katoh

Full Text Available Citrus greening (huanglongbing is the most destructive citrus disease worldwide. The disease is associated with three species of 'Candidatus Liberibacter' among which 'Ca. Liberibacter asiaticus' has the widest distribution. 'Ca. L. asiaticus' is commonly transmitted by a phloem-feeding insect vector, the Asian citrus psyllid Diaphorina citri. A previous study showed that isolates of 'Ca. L. asiaticus' were clearly differentiated by variable number of tandem repeat (VNTR profiles at four loci in the genome. In this study, the VNTR analysis was further validated by assessing the stability of these repeats after multiplication of the pathogen upon host-to-host transmission using a 'Ca. L. asiaticus' strain from Japan. The results showed that some tandem repeats showed detectable changes after insect transmission. To our knowledge, this is the first report to demonstrate that the repeat numbers VNTR 002 and 077 of 'Ca. L. asiaticus' change through psyllid transmission. VNTRs in the recipient plant were apparently unrelated to the growing phase of the vector. In contrast, changes in the number of tandem repeats increased with longer acquisition and inoculation access periods, whereas changes were not observed through psyllid transmission after relatively short acquisition and inoculation access periods, up to 20 and 19 days, respectively.

Preservice science teachers' experiences with repeated, guided inquiry

Science.gov (United States)

Slack, Amy B.

The purpose of this study was to examine preservice science teachers' experiences with repeated scientific inquiry (SI) activities. The National Science Education Standards (National Research Council, 1996) stress students should understand and possess the abilities to do SI. For students to meet these standards, science teachers must understand and be able to perform SI; however, previous research demonstrated that many teachers have naive understandings in this area. Teacher preparation programs provide an opportunity to facilitate the development of inquiry understandings and abilities. In this study, preservice science teachers had experiences with two inquiry activities that were repeated three times each. The research questions for this study were (a) How do preservice science teachers' describe their experiences with repeated, guided inquiry activities? (b) What are preservice science teachers' understandings and abilities of SI? This study was conducted at a large, urban university in the southeastern United States. The 5 participants had bachelor's degrees in science and were enrolled in a graduate science education methods course. The researcher was one of the course instructors but did not lead the activities. Case study methodology was used. Data was collected from a demographic survey, an open-ended questionnaire with follow-up interviews, the researcher's observations, participants' lab notes, personal interviews, and participants' journals. Data were coded and analyzed through chronological data matrices to identify patterns in participants' experiences. The five domains identified in this study were understandings of SI, abilities to conduct SI, personal feelings about the experience, science content knowledge, and classroom implications. Through analysis of themes identified within each domain, the four conclusions made about these preservice teachers' experiences with SI were that the experience increased their abilities to conduct inquiry

High-Dimensional Multivariate Repeated Measures Analysis with Unequal Covariance Matrices

Science.gov (United States)

Harrar, Solomon W.; Kong, Xiaoli

2015-01-01

In this paper, test statistics for repeated measures design are introduced when the dimension is large. By large dimension is meant the number of repeated measures and the total sample size grow together but either one could be larger than the other. Asymptotic distribution of the statistics are derived for the equal as well as unequal covariance cases in the balanced as well as unbalanced cases. The asymptotic framework considered requires proportional growth of the sample sizes and the dimension of the repeated measures in the unequal covariance case. In the equal covariance case, one can grow at much faster rate than the other. The derivations of the asymptotic distributions mimic that of Central Limit Theorem with some important peculiarities addressed with sufficient rigor. Consistent and unbiased estimators of the asymptotic variances, which make efficient use of all the observations, are also derived. Simulation study provides favorable evidence for the accuracy of the asymptotic approximation under the null hypothesis. Power simulations have shown that the new methods have comparable power with a popular method known to work well in low-dimensional situation but the new methods have shown enormous advantage when the dimension is large. Data from Electroencephalograph (EEG) experiment is analyzed to illustrate the application of the results. PMID:26778861

Joint Ordering and Pricing Decisions for New Repeat-Purchase Products

Directory of Open Access Journals (Sweden)

Xiang Wu

2015-01-01

Full Text Available This paper studies ordering and pricing problems for new repeat-purchase products. We incorporate the repeat-purchase rate and price effects into the Bass model to characterize the demand pattern. We consider two decision models: (1 two-stage decision model, in which the sales division chooses a price to maximize the gross profit and the purchasing division determines an optimal ordering decision to minimize the total cost under a given demand subsequently, and (2 joint decision model, in which the firm makes ordering and pricing decisions simultaneously to maximize the profit. We combine the generalized Bass model with dynamic lot sizing model to formulate the joint decision model. We apply both models to a specific imported food provided by an online fresh produce retailer in Central China, solve them by Gaussian Random-Walk and Wagner-Whitin based algorithms, and observe three results. First, joint pricing and ordering decisions bring more significant profits than making pricing and ordering decisions sequentially. Second, a great initiative in adoption significantly increases price premium and profit. Finally, the optimal price shows a U-shape (i.e., decreases first and increases later relationship and the profit increases gradually with the repeat-purchase rate when it is still not very high.

Distribution and Evolution of Yersinia Leucine-Rich Repeat Proteins

Science.gov (United States)

Hu, Yueming; Huang, He; Hui, Xinjie; Cheng, Xi; White, Aaron P.

2016-01-01

Leucine-rich repeat (LRR) proteins are widely distributed in bacteria, playing important roles in various protein-protein interaction processes. In Yersinia, the well-characterized type III secreted effector YopM also belongs to the LRR protein family and is encoded by virulence plasmids. However, little has been known about other LRR members encoded by Yersinia genomes or their evolution. In this study, the Yersinia LRR proteins were comprehensively screened, categorized, and compared. The LRR proteins encoded by chromosomes (LRR1 proteins) appeared to be more similar to each other and different from those encoded by plasmids (LRR2 proteins) with regard to repeat-unit length, amino acid composition profile, and gene expression regulation circuits. LRR1 proteins were also different from LRR2 proteins in that the LRR1 proteins contained an E3 ligase domain (NEL domain) in the C-terminal region or an NEL domain-encoding nucleotide relic in flanking genomic sequences. The LRR1 protein-encoding genes (LRR1 genes) varied dramatically and were categorized into 4 subgroups (a to d), with the LRR1a to -c genes evolving from the same ancestor and LRR1d genes evolving from another ancestor. The consensus and ancestor repeat-unit sequences were inferred for different LRR1 protein subgroups by use of a maximum parsimony modeling strategy. Structural modeling disclosed very similar repeat-unit structures between LRR1 and LRR2 proteins despite the different unit lengths and amino acid compositions. Structural constraints may serve as the driving force to explain the observed mutations in the LRR regions. This study suggests that there may be functional variation and lays the foundation for future experiments investigating the functions of the chromosomally encoded LRR proteins of Yersinia. PMID:27217422

Medial temporal lobe-dependent repetition suppression and enhancement due to implicit versus explicit processing of individual repeated search displays

Directory of Open Access Journals (Sweden)

Thomas eGeyer

2012-10-01

Full Text Available Using visual search, functional magnetic resonance imaging (fMRI and patient studies have demonstrated that medial temporal lobe (MTL structures differentiate repeated from novel displays – even when observers are unaware of display repetitions. This suggests a role for MTL in both explicit and, importantly, implicit learning of repeated sensory information (Greene et al., 2007. However, recent behavioral studies suggest, by examining visual search and recognition performance concurrently, that observers have explicit knowledge of at least some of the repeated displays (Geyer et al., 2010. The aim of the present fMRI study was thus to contribute new evidence regarding the contribution of MTL structures to explicit versus implicit learning in visual search. It was found that MTL activation was increased for explicit and, respectively, decreased for implicit relative to baseline displays. These activation differences were most pronounced in left anterior parahippocampal cortex, especially when observers were highly trained on the repeated displays. The data are taken to suggest that explicit and implicit memory processes are linked within MTL structures, but expressed via functionally separable mechanisms (repetition enhancement vs. -suppression. They further show that repetition effects in visual search would have to be investigated at the display level.

New design for a space cryo-mechanism

Science.gov (United States)

Durand, Gilles; Amiaux, Jérôme; Augueres, Jean-Louis; Carty, Michael; Barrière, Jean Christophe; Bouzat, Marylène; Duboué, Bruno; Lagage, Pierre Olivier; Lebeuf, Didier; Lepage, Erwan; Lemer, Isabelle; Marlaguey, Nathalie Peydrol; Poupar, Sébastien

2008-07-01

Based on its experience of space application instrument and its development of cryomechanism for astronomical ground based instrument VLT / VISIR, CEA Saclay is proposing a new concept of Space Cryomechanism. This design is based on VLT/VISIR cryo-mechanism design adapted to space requirements taking into account all the specification of space environment (vibrations at launch, cryogenic vacuum, materials, radiations, ...). The original concept of the design is based on the association of the key elements: a dog-clutch with Hirth teeth jaws coupled to a step-by-step space qualified cryo-motor, a bellows that allows for separation of indexing and rotating functions, and enlarged bearings design in "O" arrangement that increase robustness to vibration. The actuator has 360 steady positions that can be reached within les than a second with repeatability of 5 arcsec peak to peak. After a presentation of the details of the concept and of its benefits to robustness to space environment, the paper describes the thoroughly qualification program of the cryo-mechanism with respect to space requirements (cryo-cycling, indexing accuracy, power consumption, heat dissipation, motorisation margins, vibrations). This cryo-mechanism may be built in 3 different sizes for wheels up to 10 kg.

The right time to learn: mechanisms and optimization of spaced learning

Science.gov (United States)

Smolen, Paul; Zhang, Yili; Byrne, John H.

2016-01-01

For many types of learning, spaced training, which involves repeated long inter-trial intervals, leads to more robust memory formation than does massed training, which involves short or no intervals. Several cognitive theories have been proposed to explain this superiority, but only recently have data begun to delineate the underlying cellular and molecular mechanisms of spaced training, and we review these theories and data here. Computational models of the implicated signalling cascades have predicted that spaced training with irregular inter-trial intervals can enhance learning. This strategy of using models to predict optimal spaced training protocols, combined with pharmacotherapy, suggests novel ways to rescue impaired synaptic plasticity and learning. PMID:26806627

Improvement of recovery and repeatability in liquid chromatography-mass spectrometry analysis of peptides

NARCIS (Netherlands)

van Midwoud, Paul M.; Rieux, Laurent; Bischoff, Rainer; Verpoorte, Elisabeth; Niederlander, Harm A. G.

2007-01-01

Poor repeatability of peak areas is a problem frequently encountered in peptide analysis with nanoLiquid Chromatography coupled on-line with Mass Spectrometry (nanoLC-MS). As a result, quantitative analysis will be seriously hampered unless the observed variability can be corrected in some way.

Repeatability of measures of inflammatory cell number in bronchial biopsies in atopic asthma

NARCIS (Netherlands)

Sont, J. K.; Willems, L. N.; Evertse, C. E.; Hooijer, R.; Sterk, P. J.; van Krieken, J. H.

1997-01-01

Airway pathology is increasingly considered to be a major outcome in asthma research. The aim of this study was to examine the intra-observer, within-section and between-biopsy repeatability, together with the implications for statistical power of a computerized quantitative analysis of inflammatory

Volcanic and Hydrothermal Activity of the North Su Volcano: New Insights from Repeated Bathymetric Surveys and ROV Observations

Science.gov (United States)

Thal, J.; Bach, W.; Tivey, M.; Yoerger, D.

2013-12-01

Bathymetric data from cruises in 2002, 2006, and 2011 were combined and compared to determine the evolution of volcanic activity, seafloor structures, erosional features and to identify and document the distribution of hydrothermal vents on North Su volcano, SuSu Knolls, eastern Manus Basin (Papua New Guinea). Geologic mapping based on ROV observations from 2006 (WHOI Jason-2) and 2011 (MARUM Quest-4000) combined with repeated bathymetric surveys from 2002 and 2011 are used to identify morphologic features on the slopes of North Su and to track temporal changes. ROV MARUM Quest-4000 bathymetry was used to develop a 10 m grid of the top of North Su to precisely depict recent changes. In 2006, the south slope of North Su was steeply sloped and featured numerous white smoker vents discharging acid sulfate waters. These vents were covered by several tens of meters of sand- to gravel-sized volcanic material in 2011. The growth of this new cone changed the bathymetry of the south flank of North Su up to ~50 m and emplaced ~0.014 km3 of clastic volcanic material. This material is primarily comprised of fractured altered dacite and massive fresh dacite as well as crystals of opx, cpx, olivine and plagioclase. There is no evidence for pyroclastic fragmentation, so we hypothesize that the fragmentation is likely related to hydrothermal explosions. Hydrothermal activity varies over a short (~50 m) lateral distance from 'flashing' black smokers to acidic white smoker vents. Within 2 weeks of observation time in 2011, the white smoker vents varied markedly in activity suggesting a highly episodic hydrothermal system. Based on ROV video recordings, we identified steeply sloping (up to 30°) slopes exposing pillars and walls of hydrothermal cemented volcaniclastic material representing former fluid upflow zones. These features show that hydrothermal activity has increased slope stability as hydrothermal cementation has prevented slope collapse. Additionally, in some places

Earth observations during Space Shuttle mission STS-45 Mission to Planet Earth - March 24-April 2, 1992

Science.gov (United States)

Pitts, David E.; Helfert, Michael R.; Lulla, Kamlesh P.; Mckay, Mary F.; Whitehead, Victor S.; Amsbury, David L.; Bremer, Jeffrey; Ackleson, Steven G.; Evans, Cynthia A.; Wilkinson, M. J.

1992-01-01

A description is presented of the activities and results of the Space Shuttle mission STS-45, known as the Mission to Planet Earth. Observations of Mount St. Helens, Manila Bay and Mt. Pinatubo, the Great Salt Lake, the Aral Sea, and the Siberian cities of Troitsk and Kuybyshev are examined. The geological features and effects of human activity seen in photographs of these areas are pointed out.

Acceleration of H, He, and heavy ions observed in the magnetosheath, magnetotail, and near-by interplanetary space

International Nuclear Information System (INIS)

Fan, C.Y.; Gloeckler, G.; Hovestadt, D.

1975-01-01

Pulses of electrons and ions composed of H, He, and heavier elements were observed in the magnetosheath, magnetotail, and near-by interplanetary space. From the spatial positions where these particles were detected and the ion flow directions we conclude that they were accelerated at the bow shock near the sub-solar point and in the near-earth region of the neutral sheet of the magnetotail. (orig.) [de

Hubble Space Telescope Wide Field Planetary Camera 2 Observations of Neptune

Science.gov (United States)

1995-01-01

Two groups have recently used the Hubble Space Telescope (HST) Wide Field Planetary Camera 2 (WFPC 2) to acquire new high-resolution images of the planet Neptune. Members of the WFPC-2 Science Team, lead by John Trauger, acquired the first series of images on 27 through 29 June 1994. These were the highest resolution images of Neptune taken since the Voyager-2 flyby in August of 1989. A more comprehensive program is currently being conducted by Heidi Hammel and Wes Lockwood. These two sets of observations are providing a wealth of new information about the structure, composition, and meteorology of this distant planet's atmosphere.Neptune is currently the most distant planet from the sun, with an orbital radius of 4.5 billion kilometers (2.8 billion miles, or 30 Astronomical Units). Even though its diameter is about four times that of the Earth (49,420 vs. 12,742 km), ground-based telescopes reveal a tiny blue disk that subtends less than 1/1200 of a degree (2.3 arc-seconds). Neptune has therefore been a particularly challenging object to study from the ground because its disk is badly blurred by the Earth's atmosphere. In spite of this, ground-based astronomers had learned a great deal about this planet since its position was first predicted by John C. Adams and Urbain Leverrier in 1845. For example, they had determined that Neptune was composed primarily of hydrogen and helium gas, and that its blue color caused by the presence of trace amounts of the gas methane, which absorbs red light. They had also detected bright cloud features whose brightness changed with time, and tracked these clouds to infer a rotation period between 17 and 22 hours.When the Voyager-2 spacecraft flew past the Neptune in 1989, its instruments revealed a surprising array of meteorological phenomena, including strong winds, bright, high-altitude clouds, and two large dark spots attributed to long-lived giant storm systems. These bright clouds and dark spots were tracked as they moved

Resistance of human spermatozoa to cryoinjury in repeated cycles of thaw-refreezing

Directory of Open Access Journals (Sweden)

Sidney Verza Jr.

2009-10-01

Full Text Available Objective: To study the resistance of human spermatozoa to cryoinjury in repeated cycles of thaw-refreezing by using the fast liquid nitrogen vapor method. Material and Methods: Semen specimens were obtained from sixteen normal and oligozoospermic individuals who required disposal at the sperm bank. Five of them had testicular cancer. Specimens were thawed and an aliquot was removed for analysis. The remaining specimens were refrozen without removing the cryomedia. Repeated freeze-thaw cycles were performed until no motile sperm were observed. Sperm motility, number of motile spermatozoa and viability were determined after thawing. Resistance to cryoinjury was compared between groups and also after each refreezing cycle within groups. Results: Motile spermatozoa were recovered after five and two refreeze-thawing cycles in normozoospermic and oligozoospermic specimens, respectively. There were no significant differences in the recovery of motile spermatozoa between thaws within each group of normal and oligozoospermic specimens, but percentage motility and total number of motile spermatozoa were significantly lower in the oligozoospermic one. Specimens from men with cancer were exposed to six refreeze-thawing cycles. Although recovery of motile spermatozoa was significantly impaired after each thawing, there were no significant differences in the recovery of motile sperm between thaws in cancer and non-cancer groups. Conclusions: Human spermatozoa resist repeated cryopreservation using the fast liquid nitrogen vapor method. Normozoospermic specimens withstand refreezing for an average two cycles longer than oligozoospermic ones. Specimens from cancer patients seem to resist repeated cryoinjury similarly to non-cancer counterparts. Resistance to repeated cryoinjury was related to the initial semen quality.

Adaptation of the pituitary-adrenal axis to daily repeated forced swim exposure in rats is dependent on the temperature of water.

Science.gov (United States)

Rabasa, Cristina; Delgado-Morales, Raúl; Gómez-Román, Almudena; Nadal, Roser; Armario, Antonio

2013-11-01

Comparison of exposure to certain predominantly emotional stressors reveals a qualitatively similar neuroendocrine response profile as well as a reduction of physiological responses after daily repeated exposure (adaptation). However, particular physical components of the stressor may interfere with adaptation. As defective adaptation to stress can enhance the probability to develop pathologies, we studied in adult male rats (n = 10/group) swimming behavior (struggling, immobility and mild swim) and physiological responses (ACTH, corticosterone and rectal temperature) to daily repeated exposure to forced swim (20 min, 13 d) at 25 or 36 °C (swim25 or swim36). Rats were repeatedly blood-sampled by tail-nick and hormones measured by radioimmunoassay. Some differences were observed between the two swim temperature groups after the first exposure to forced swim: (a) active behaviors were greater in swim25 than swim36 groups; (b) swim25 but not swim36 caused hypothermia; and (c) swim36 elicited the same ACTH response as swim25, but plasma corticosterone concentration was lower for swim36 at 30 min post-swim. After daily repeated exposure, adaptation in ACTH secretion was observed with swim36 already on day 4, whereas with swim25 adaptation was not observed until day 13 and was of lower magnitude. Nevertheless, after repeated exposure to swim25 a partial protection from hypothermia was observed and the two swim conditions resulted in progressive reduction of active behaviors. Thus, daily repeated swim at 25 °C impairs adaptation of the hypothalamic-pituitary-adrenal axis as compared to swim at 36 °C, supporting the hypothesis that certain physical components of predominantly emotional stressors can interfere with the process of adaptation.

Adaptive Changes in Sensorimotor Coordination and Motion Sickness Following Repeated Exposures to Virtual Environments

Science.gov (United States)

Harm, D. L.; Taylor, L. C.; Bloomberg, J. J.

2007-01-01

Virtual environments offer unique training opportunities, particularly for training astronauts and preadapting them to the novel sensory conditions of microgravity. Two unresolved human factors issues in virtual reality (VR) systems are: 1) potential "cybersickness", and 2) maladaptive sensorimotor performance following exposure to VR systems. Interestingly, these aftereffects are often quite similar to adaptive sensorimotor responses observed in astronauts during and/or following space flight. Initial interpretation of novel sensory information may be inappropriate and result in perceptual errors. Active exploratory behavior in a new environment, with resulting feedback and the formation of new associations between sensory inputs and response outputs, promotes appropriate perception and motor control in the new environment. Thus, people adapt to consistent, sustained alterations of sensory input such as those produced by microgravity, unilateral labyrinthectomy and experimentally produced stimulus rearrangements. The purpose of this research was to compare disturbances in sensorimotor coordination produced by dome and head-mounted virtual environment displays and to examine the effects of exposure duration, and repeated exposures to VR systems. The first study examined disturbances in balance control, and the second study examined disturbances in eye-head-hand (EHH) and eye-head coordination.

Toward Microsatellite Based Space Situational Awareness

Science.gov (United States)

Scott, L.; Wallace, B.; Sale, M.; Thorsteinson, S.

2013-09-01

The NEOSSat microsatellite is a dual mission space telescope which will perform asteroid detection and Space Situational Awareness (SSA) observation experiments on deep space, earth orbiting objects. NEOSSat was launched on 25 February 2013 into a 800 dawn-dusk sun synchronous orbit and is currently undergoing satellite commissioning. The microsatellite consists of a small aperture optical telescope, GPS receiver, high performance attitude control system, and stray light rejection baffle designed to reject stray light from the Sun while searching for asteroids with elongations 45 degrees along the ecliptic. The SSA experimental mission, referred to as HEOSS (High Earth Orbit Space Surveillance), will focus on objects in deep space orbits. The HEOSS mission objective is to evaluate the utility of microsatellites to perform catalog maintenance observations of resident space objects in a manner consistent with the needs of the Canadian Forces. The advantages of placing a space surveillance sensor in low Earth orbit are that the observer can conduct observations without the day-night interruption cycle experienced by ground based telescopes, the telescope is insensitive to adverse weather and the system has visibility to deep space resident space objects which are not normally visible from ground based sensors. Also, from a photometric standpoint, the microsatellite is able to conduct observations on objects with a rapidly changing observer position. The possibility of spin axis estimation on geostationary satellites may be possible and an experiment characterize spin axis of distant resident space objects is being planned. Also, HEOSS offers the ability to conduct observations of satellites at high phase angles which can potentially extend the trackable portion of space in which deep space objects' orbits can be monitored. In this paper we describe the HEOSS SSA experimental data processing system and the preliminary findings of the catalog maintenance experiments

Local toxicity of benzalkonium chloride in ophthalmic solutions following repeated applications.

Science.gov (United States)

Okahara, Akihiko; Kawazu, Kouichi

2013-01-01

We performed repeated toxicity studies of benzalkonium chloride (BAK)-containing vehicles of ophthalmic solutions in monkeys and rabbits to assess the local toxicity of BAK after repeated applications on the ocular surface. Local toxicity of BAK was evaluated by toxicity studies in which a 0.01% BAK-containing vehicle was applied twice/day for 52 weeks, 4 times/day for 39 weeks, or 6 times/day for 13 weeks, or in which a 0.005% BAK-containing vehicle was applied 6 times/day for 52 weeks or twice/day for 4 weeks in monkeys. Local toxicity of BAK was also evaluated where a 0.01% BAK-containing vehicle was applied 6 times/day for 6 weeks, or a 0.005% BAK-containing vehicle was applied twice/day for 39 weeks or 8 times/day for 4 weeks in rabbits. These doses were chosen because BAK is generally used at concentrations up to 0.01% in ophthalmic solutions. The BAK-containing vehicle did not cause ophthalmological changes suggestive of irritation, allergy, or corneal damage. We also did not observe any histopathological changes in the eyeball, eyelid, lacrimal gland, and nasal cavity, with repeated applications of BAK for up to 52 weeks, up to 8 times/day, or at concentrations up to 0.01%, in monkeys and rabbits. Our results suggest that BAK in concentrations up to 0.01% in ophthalmic solution is non-toxic to the eyeball, its accessory organs, and the nasal cavity after long repeated applications.

Extending Supernova Spectral Templates for Next Generation Space Telescope Observations

Science.gov (United States)

Roberts-Pierel, Justin; Rodney, Steven A.; Steven Rodney

2018-01-01

Widely used empirical supernova (SN) Spectral Energy Distributions (SEDs) have not historically extended meaningfully into the ultraviolet (UV), or the infrared (IR). However, both are critical for current and future aspects of SN research including UV spectra as probes of poorly understood SN Ia physical properties, and expanding our view of the universe with high-redshift James Webb Space Telescope (JWST) IR observations. We therefore present a comprehensive set of SN SED templates that have been extended into the UV and IR, as well as an open-source software package written in Python that enables a user to generate their own extrapolated SEDs. We have taken a sampling of core-collapse (CC) and Type Ia SNe to get a time-dependent distribution of UV and IR colors (U-B,r’-[JHK]), and then generated color curves are used to extrapolate SEDs into the UV and IR. The SED extrapolation process is now easily duplicated using a user’s own data and parameters via our open-source Python package: SNSEDextend. This work develops the tools necessary to explore the JWST’s ability to discriminate between CC and Type Ia SNe, as well as provides a repository of SN SEDs that will be invaluable to future JWST and WFIRST SN studies.

Novel expressed sequence tag- simple sequence repeats (EST ...

African Journals Online (AJOL)

Using different bioinformatic criteria, the SUCEST database was used to mine for simple sequence repeat (SSR) markers. Among 42,189 clusters, 1,425 expressed sequence tag- simple sequence repeats (EST-SSRs) were identified in silico. Trinucleotide repeats were the most abundant SSRs detected. Of 212 primer pairs ...

O-6 Optical Property Degradation of the Hubble Space Telescope's Wide Field Camera-2 Pick Off Mirror

Science.gov (United States)

McNamara, Karen M.; Hughes, D. W.; Lauer, H. V.; Burkett, P. J.; Reed, B. B.

2011-01-01

Degradation in the performance of optical components can be greatly affected by exposure to the space environment. Many factors can contribute to such degradation including surface contaminants; outgassing; vacuum, UV, and atomic oxygen exposure; temperature cycling; or combinations of parameters. In-situ observations give important clues to degradation processes, but there are relatively few opportunities to correlate those observations with post-flight ground analyses. The return of instruments from the Hubble Space Telescope (HST) after its final servicing mission in May 2009 provided such an opportunity. Among the instruments returned from HST was the Wide-Field Planetary Camera-2 (WFPC-2), which had been exposed to the space environment for 16 years. This work focuses on the identifying the sources of degradation in the performance of the Pick-off mirror (POM) from WFPC-2. Techniques including surface reflectivity measurements, spectroscopic ellipsometry, FTIR (and ATR-FTIR) analyses, SEM/EDS, X-ray photoelectron spectroscopy (XPS) with and without ion milling, and wet and dry physical surface sampling were performed. Destructive and contact analyses took place only after completion of the non-destructive measurements. Spectroscopic ellipsometry was then repeated to determine the extent of contaminant removal by the destructive techniques, providing insight into the nature and extent of polymerization of the contaminant layer.

The case for repeatable analysis with energy economy optimization models

International Nuclear Information System (INIS)

DeCarolis, Joseph F.; Hunter, Kevin; Sreepathi, Sarat

2012-01-01

Energy economy optimization (EEO) models employ formal search techniques to explore the future decision space over several decades in order to deliver policy-relevant insights. EEO models are a critical tool for decision-makers who must make near-term decisions with long-term effects in the face of large future uncertainties. While the number of model-based analyses proliferates, insufficient attention is paid to transparency in model development and application. Given the complex, data-intensive nature of EEO models and the general lack of access to source code and data, many of the assumptions underlying model-based analysis are hidden from external observers. This paper discusses the simplifications and subjective judgments involved in the model building process, which cannot be fully articulated in journal papers, reports, or model documentation. In addition, we argue that for all practical purposes, EEO model-based insights cannot be validated through comparison to real world outcomes. As a result, modelers are left without credible metrics to assess a model's ability to deliver reliable insight. We assert that EEO models should be discoverable through interrogation of publicly available source code and data. In addition, third parties should be able to run a specific model instance in order to independently verify published results. Yet a review of twelve EEO models suggests that in most cases, replication of model results is currently impossible. We provide several recommendations to help develop and sustain a software framework for repeatable model analysis.

Observations of Heliospheric Faraday Rotation (FR) and Interplanetary Scintillation (IPS) with the LOw Frequency ARray (LOFAR): Steps Towards Improving Space-Weather Forecasting Capabilities

Science.gov (United States)

Bisi, M. M.; Fallows, R. A.; Sobey, C.; Eftekhari, T.; Jensen, E. A.; Jackson, B. V.; Yu, H. S.; Hick, P. P.; Odstrcil, D.; Tokumaru, M.

2015-12-01

The phenomenon of space weather - analogous to terrestrial weather which describes the changing pressure, temperature, wind, and humidity conditions on Earth - is essentially a description of the changes in velocity, density, magnetic field, high-energy particles, and radiation in the near-Earth space environment including the effects of such changes on the Earth's magnetosphere, radiation belts, ionosphere, and thermosphere. Space weather can be considered to have two main strands: (i) scientific research, and (ii) applications. The former is self-explanatory, but the latter covers operational aspects which includes its forecasting. Understanding and forecasting space weather in the near-Earth environment is vitally important to protecting our modern-day reliance (militarily and commercially) on satellites, global-communication and navigation networks, high-altitude air travel (radiation concerns particularly on polar routes), long-distance power/oil/gas lines and piping, and for any future human exploration of space to list but a few. Two ground-based radio-observing remote-sensing techniques that can aid our understanding and forecasting of heliospheric space weather are those of interplanetary scintillation (IPS) and heliospheric Faraday rotation (FR). The LOw Frequency ARray (LOFAR) is a next-generation 'software' radio telescope centered in The Netherlands with international stations spread across central and northwest Europe. For several years, scientific observations of IPS on LOFAR have been undertaken on a campaign basis and the experiment is now well developed. More recently, LOFAR has been used to attempt scientific heliospheric FR observations aimed at remotely sensing the magnetic field of the plasma traversing the inner heliosphere. We present our latest progress using these two radio heliospheric-imaging remote-sensing techniques including the use of three-dimensional (3-D) modeling and reconstruction techniques using other, additional data as input

Visual imagery in autobiographical memory: The role of repeated retrieval in shifting perspective

Science.gov (United States)

Butler, Andrew C.; Rice, Heather J.; Wooldridge, Cynthia L.; Rubin, David C.

2016-01-01

Recent memories are generally recalled from a first-person perspective whereas older memories are often recalled from a third-person perspective. We investigated how repeated retrieval affects the availability of visual information, and whether it could explain the observed shift in perspective with time. In Experiment 1, participants performed mini-events and nominated memories of recent autobiographical events in response to cue words. Next, they described their memory for each event and rated its phenomenological characteristics. Over the following three weeks, they repeatedly retrieved half of the mini-event and cue-word memories. No instructions were given about how to retrieve the memories. In Experiment 2, participants were asked to adopt either a first- or third-person perspective during retrieval. One month later, participants retrieved all of the memories and again provided phenomenology ratings. When first-person visual details from the event were repeatedly retrieved, this information was retained better and the shift in perspective was slowed. PMID:27064539

Role of memory errors in quantum repeaters

International Nuclear Information System (INIS)

Hartmann, L.; Kraus, B.; Briegel, H.-J.; Duer, W.

2007-01-01

We investigate the influence of memory errors in the quantum repeater scheme for long-range quantum communication. We show that the communication distance is limited in standard operation mode due to memory errors resulting from unavoidable waiting times for classical signals. We show how to overcome these limitations by (i) improving local memory and (ii) introducing two operational modes of the quantum repeater. In both operational modes, the repeater is run blindly, i.e., without waiting for classical signals to arrive. In the first scheme, entanglement purification protocols based on one-way classical communication are used allowing to communicate over arbitrary distances. However, the error thresholds for noise in local control operations are very stringent. The second scheme makes use of entanglement purification protocols with two-way classical communication and inherits the favorable error thresholds of the repeater run in standard mode. One can increase the possible communication distance by an order of magnitude with reasonable overhead in physical resources. We outline the architecture of a quantum repeater that can possibly ensure intercontinental quantum communication

Comparing observer models and feature selection methods for a task-based statistical assessment of digital breast tomsynthesis in reconstruction space

Science.gov (United States)

Park, Subok; Zhang, George Z.; Zeng, Rongping; Myers, Kyle J.

2014-03-01

A task-based assessment of image quality1 for digital breast tomosynthesis (DBT) can be done in either the projected or reconstructed data space. As the choice of observer models and feature selection methods can vary depending on the type of task and data statistics, we previously investigated the performance of two channelized- Hotelling observer models in conjunction with 2D Laguerre-Gauss (LG) and two implementations of partial least squares (PLS) channels along with that of the Hotelling observer in binary detection tasks involving DBT projections.2, 3 The difference in these observers lies in how the spatial correlation in DBT angular projections is incorporated in the observer's strategy to perform the given task. In the current work, we extend our method to the reconstructed data space of DBT. We investigate how various model observers including the aforementioned compare for performing the binary detection of a spherical signal embedded in structured breast phantoms with the use of DBT slices reconstructed via filtered back projection. We explore how well the model observers incorporate the spatial correlation between different numbers of reconstructed DBT slices while varying the number of projections. For this, relatively small and large scan angles (24° and 96°) are used for comparison. Our results indicate that 1) given a particular scan angle, the number of projections needed to achieve the best performance for each observer is similar across all observer/channel combinations, i.e., Np = 25 for scan angle 96° and Np = 13 for scan angle 24°, and 2) given these sufficient numbers of projections, the number of slices for each observer to achieve the best performance differs depending on the channel/observer types, which is more pronounced in the narrow scan angle case.

Comparison of step-by-step kinematics in repeated 30m sprints in female soccer players.

Science.gov (United States)

van den Tillaar, Roland

2018-01-04

The aim of this study was to compare kinematics in repeated 30m sprints in female soccer players. Seventeen subjects performed seven 30m sprints every 30s in one session. Kinematics were measured with an infrared contact mat and laser gun, and running times with an electronic timing device. The main findings were that sprint times increased in the repeated sprint ability test. The main changes in kinematics during the repeated sprint ability test were increased contact time and decreased step frequency, while no change in step length was observed. The step velocity increased in almost each step until the 14, which occurred around 22m. After this, the velocity was stable until the last step, when it decreased. This increase in step velocity was mainly caused by the increased step length and decreased contact times. It was concluded that the fatigue induced in repeated 30m sprints in female soccer players resulted in decreased step frequency and increased contact time. Employing this approach in combination with a laser gun and infrared mat for 30m makes it very easy to analyse running kinematics in repeated sprints in training. This extra information gives the athlete, coach and sports scientist the opportunity to give more detailed feedback and help to target these changes in kinematics better to enhance repeated sprint performance.

Ocular surface sensitivity repeatability with Cochet-Bonnet esthesiometer.

Science.gov (United States)

Chao, Cecilia; Stapleton, Fiona; Badarudin, Ezailina; Golebiowski, Blanka

2015-02-01

To determine the repeatability of ocular surface threshold measurements using the Cochet-Bonnet esthesiometer on the same day and 3 months apart. Two separate studies were conducted to determine the repeatability of ocular surface threshold measurements made on the same day (n = 20 subjects) and 3 months apart (n = 29 subjects). The Cochet-Bonnet esthesiometer was used to measure corneal and inferior conjunctival thresholds using the ascending method of limits. The pressure exerted by the Cochet-Bonnet esthesiometer was determined using an analytical balance, for both the 0.08- and 0.12-mm-diameter filaments. This calibration was then used to convert filament length measurements to pressure. Repeatability was determined using a Bland and Altman analysis. The pressure exerted at each filament length differed between the two filament diameters. The measured pressure also differed from values provided by the manufacturer. Repeatability of threshold measurements at the central cornea was shown to be good, with better repeatability for same-day measurements (coefficient of repeatability [CoR] = ±0.23 g/mm²) than for those 3 months apart (CoR = ±0.52 g/mm²). Threshold measurements at the inferior conjunctiva, in contrast, were poorly repeatable (CoR = ±12.78 g/mm²). Cochet-Bonnet esthesiometry is repeatable when performed on the central cornea on the same day and 3 months apart, but this instrument is not recommended for conjunctival threshold measurements.

Repeat Mapping in the Lower Monterey Submarine Canyon Sheds Light on Morphological Change During Discrete Sediment Density Flow Events

Science.gov (United States)

Anderson, K.; Lundsten, E. M.; Caress, D. W.; Thomas, H. J.; Paull, C. K.; Maier, K. L.; Gales, J. A.; Gwiazda, R.; Talling, P.; Xu, J.; Parsons, D. R.

2017-12-01

The Coordinated Canyon Experiment (CCE), a multi-institutional collaboration effort, was designed to monitor the passage of sediment density flows along the axis of Monterey Canyon, offshore California, between 200 and 1850 m water depth. An array of moorings and sensors were deployed for three 6-month periods from October 2015 to April 2017. Aligned with the CCE deployments, repeat high-resolution multibeam bathymetric surveys of the Monterey Canyon floor were conducted with a mapping AUV (Autonomous Underwater Vehicle). The AUV carried a Reson 7125 multibeam echosounder (vertical precision of 0.15 m and horizontal resolution of 1.0 m). An inertial navigation system combined with a Doppler velocity logger allowed the AUV to fly pre-programmed grids at 3 knots, while maintaining an altitude of 50 m above the seafloor, to obtain a nominal line spacing of 130 m. The floor and lower flanks of the canyon between 200 to 540 m and 1350 to 1880 m water depths were mapped six times during the CCE. These repeat maps are subtracted to create bathymetry difference grids to show morphological change. Coupling the sensor observations with the bathymetric surveys, the CCE successfully documented sediment density flow events as well as the associated changes in seafloor morphology. Between repeat surveys, three sediment density flow events reached the lower canyon, extending to at least 1850 m water depth. On January 15, 2016, a particularly large density flow traveled more than 50 km down Monterey Canyon. Unlike in the upper canyon where this event caused wholesale reorganization of geomorphological features, changes to the lower canyon morphology involved a more moderate re-sculpting of the features. The effect of a sediment density flow of known magnitude and duration on the seafloor morphology has never been documented in a deep-sea setting before.

Implementation of repeat HIV testing during pregnancy in Kenya: a qualitative study.

Science.gov (United States)

Rogers, Anna Joy; Weke, Elly; Kwena, Zachary; Bukusi, Elizabeth A; Oyaro, Patrick; Cohen, Craig R; Turan, Janet M

2016-07-11

Repeat HIV testing in late pregnancy has the potential to decrease rates of mother-to-child transmission of HIV by identifying mothers who seroconvert after having tested negative for HIV in early pregnancy. Despite being national policy in Kenya, the available data suggest that implementation rates are low. We conducted 20 in-depth semi-structured interviews with healthcare providers and managers to explore barriers and enablers to implementation of repeat HIV testing guidelines for pregnant women. Participants were from the Nyanza region of Kenya and were purposively selected to provide variation in socio-demographics and job characteristics. Interview transcripts were coded and analyzed in Dedoose software using a thematic analysis approach. Four themes were identified a priori using Ferlie and Shortell's Framework for Change and additional themes were allowed to emerge from the data. Participants identified barriers and enablers at the client, provider, facility, and health system levels. Key barriers at the client level from the perspective of providers included late initial presentation to antenatal care and low proportions of women completing the recommended four antenatal visits. Barriers to offering repeat HIV testing for providers included heavy workloads, time limitations, and failing to remember to check for retest eligibility. At the facility level, inconsistent volume of clients and lack of space required for confidential HIV retesting were cited as barriers. Finally, at the health system level, there were challenges relating to the HIV test kit supply chain and the design of nationally standardized antenatal patient registers. Enablers to improving the implementation of repeat HIV testing included client dissemination of the benefits of antenatal care through word-of-mouth, provider cooperation and task shifting, and it was suggested that use of an electronic health record system could provide automatic reminders for retest eligibility. This study

Transmissible familial Creutzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene

Energy Technology Data Exchange (ETDEWEB)

Goldfarb, L.G.; Brown, P.; McCombie, W.R.; Gibbs, C.J. Jr.; Gajdusek, D.C. (National Inst. of Health, Bethesda, MD (United States)); Goldgaber, D. (State Univ. of New York, Stony Brook (United States)); Swergold, G.D. (National Inst. of Health, Bethesda, MD (United States)); Wills, P.R. (Univ. of Auckland (New Zealand)); Cervenakova, L. (Inst. of Preventive and Clinical Medicine, Bratislava (Czechoslovakia)); Baron, H. (Searle Pharmaceuticals, Paris (France))

1991-12-01

The PRNP gene, encoding the amyloid precursor protein that is centrally involved in Creutzfeldt-Jakob disease (CJD), has an unstable region of five variant tandem octapeptide coding repeats between codons 51 and 91. The authors screened a total of 535 individuals for the presence of extra repeats in this region, including patients with sporadic and familial forms of spongiform encephalopathy, members of their families, other neurological and non-neurological patients, and normal controls. They identified three CJD families (in each of which the proband's disease was neuropathologically confirmed and experimentally transmitted to primates) that were heterozygous for alleles with 10, 12, or 13 repeats, some of which had wobble nucleotide substitutions. They also found one individual with 9 repeats and no nucleotide substitutions who had no evidence of neurological disease. These observations, together with data on published British patients with 11 and 14 repeats, strongly suggest that the occurrence of 10 or more octapeptide repeats in the encoded amyloid precursor protein predisposes to CJD.

Clinical Observation on Termination of Early Pregnancy of 213 Cases after Caesarian Section with Repeated Use of Mifepristone and Misoprostol

Institute of Scientific and Technical Information of China (English)

高佩佩; 汪平

1999-01-01

Objective To investigate the efficacy and safety in women after caesarian section for termination of early pregnancies by treatment, or repeated treatment with mifepristone and misoprostot.Subjects and Methods A total of 213 pregnant women with amenorrhea of 34-69d after caesarian section who asked for medical abortion were recruited,including 63 cases undergoing their second medical abortion.A total amount of mi feprisstone of 150 mg given in separate doses(25 mg×4 and 50 mg at the first time)was administered orally within 3d, followed by misoprostot of 0.6 mg orally in the morning of d 3.Results The complete abortion rate was 92.5%,incomplete abortion was 4.7% and failure was 2.8%.Conclusion The sequential use of mifepristone and misoprostol could be successfully and repeatedly used for induced abortion in those women with a caesarian section histo-ry.Its efficacy was similar to that for ordinary population.Its safety and effec-tiveness were satisfactory.

Dental Fear in Children with Repeated Tooth Injuries.

Science.gov (United States)

Negovetić Vranić, Dubravka; Ivančić Jokić, Nataša; Bakarčić, Danko; Carek, Andreja; Rotim, Željko; Verzak, Željko

2016-06-01

Tooth injuries are serious clinical conditions. Some children experience dental trauma only once, while others are more prone to repeated tooth injuries. Repeated dental trauma occurs in 19.4% to 30% of patients. Pain and dental trauma are the most common reasons for fear and anxiety. The main objective of this study was to investigate how dental trauma, as well as repeated dental trauma affects the occurrence and development of dental fear in children. The study was conducted on a random sample of 147 subjects (88 boys and 59 girls) aged 5-8 and 9-12 years. Subjects in both age groups were divided into subroups without dental trauma, with one dental trauma and with repeated dental trauma. The validated Children’s Fear Survey Schedule – Dental Subscale was used on fear assessment. Results showed that only 12.2% of children without trauma, 33.3% with one trauma and 51.7% with repeated trauma were not afraid of injection. Older children had a significantly lower fear of injections, touch of an unknown person, choking, going to the hospital and people in white uniforms. Dentist was not the cause of fear in 65.5% of patients with repeated trauma. With each repeated injury of teeth, the degree of their fear of dental treatment was lower.

Erroneous Memories Arising from Repeated Attempts to Remember

Science.gov (United States)

Henkel, Linda A.

2004-01-01

The impact of repeated and prolonged attempts at remembering on false memory rates was assessed in three experiments. Participants saw and imagined pictures and then made repeated recall attempts before taking a source memory test. Although the number of items recalled increased with repeated tests, the net gains were associated with more source…

Molecular Characterization of Respiratory Syncytial Virus in Children with Repeated Infections with Subgroup B in the Philippines.

Science.gov (United States)

Okamoto, Michiko; Dapat, Clyde P; Sandagon, Ann Marie D; Batangan-Nacion, Leilanie P; Lirio, Irene C; Tamaki, Raita; Saito, Mayuko; Saito-Obata, Mariko; Lupisan, Socorro P; Oshitani, Hitoshi

2018-05-02

Human respiratory syncytial virus (RSV) is the leading cause of severe acute respiratory infection in infants and young children, which is characterized by repeated infections. However, the role of amino acid substitutions in repeated infections remains unclear. Hence, this study aimed to elucidate the genetic characteristics of RSV in children with repeated infections using molecular analyses of F and G genes. We conducted a cohort study for children younger than 5 years in the Philippines. We collected nasopharyngeal swabs from children with acute respiratory symptoms and compared F and G sequences between prior and subsequent RSV infections. We examined 1,802 children from May 2014 to January 2016 and collected 3,471 samples. Repeated infections were observed in 25 children, including 4 with homologous RSV-B reinfections. Viruses from the 4 pairs of homologous reinfections had amino acid substitutions in the G protein mostly at O-glycosylation sites, whereas changes in the F protein were identified at antigenic sites V (L173S) and θ (Q209K), considered essential epitopes for the prefusion conformation of the F protein. Amino acid substitutions in G and F proteins of RSV-B might have led to antigenic changes, potentially contributing to homologous reinfections observed in this study.

'The End of Sitting' in a public space: observations of spontaneous visitors.

Science.gov (United States)

Renaud, Lidewij R; Huysmans, Maaike A; Speklé, Erwin M; van der Beek, Allard J; van der Ploeg, Hidde P

2017-12-08

Sitting too much has been associated with negative health outcomes. 'The End of Sitting' is a newly developed office landscape that moves away from the traditional chair-desk setup. The landscape aims to reduce sitting time by offering a variety of (supported) standing positions. The aim of this study was to determine the usage of the landscape after being placed in the main entrance hall of the VU University in Amsterdam. We observed the number of spontaneous visitors as well as the duration of visits, changes to another location within the landscape, and adopted postures. Using questionnaires reasons (not) to visit the landscape, perceived affordances of the landscape and associations with long-term use were determined. Observed numbers of visitors were relatively low and duration of visits were short, which seemed to indicate visitors were trying out the landscape. The majority of visitors were in an upright position, reflecting the designers' intentions. Visitors indicated that long-term use would be pleasant to them. 'The End of Sitting' landscape received positive reactions but number of visits were limited in the few months that it was placed in the university main entrance hall. The landscape might be better suited for designated working or study spaces, for which it was originally intended. It might also be worth to explore the landscapes suitability for short stay environments, such as waiting rooms.

High-frequency data observations from space shuttle main engine low pressure fuel turbopump discharge duct flex joint tripod failure investigation

Science.gov (United States)

Zoladz, T. F.; Farr, R. A.

1991-01-01

Observations made by Marshall Space Flight Center (MSFC) engineers during their participation in the Space Shuttle Main Engine (SSME) low pressure fuel turbopump discharge duct flex joint tripod failure investigation are summarized. New signal processing techniques used by the Component Assessment Branch and the Induced Environments Branch during the failure investigation are described in detail. Moreover, nonlinear correlations between frequently encountered anomalous frequencies found in SSME dynamic data are discussed. A recommendation is made to continue low pressure fuel (LPF) duct testing through laboratory flow simulations and MSFC-managed technology test bed SSME testing.

Identification, variation and transcription of pneumococcal repeat sequences

Science.gov (United States)

2011-01-01

Background Small interspersed repeats are commonly found in many bacterial chromosomes. Two families of repeats (BOX and RUP) have previously been identified in the genome of Streptococcus pneumoniae, a nasopharyngeal commensal and respiratory pathogen of humans. However, little is known about the role they play in pneumococcal genetics. Results Analysis of the genome of S. pneumoniae ATCC 700669 revealed the presence of a third repeat family, which we have named SPRITE. All three repeats are present at a reduced density in the genome of the closely related species S. mitis. However, they are almost entirely absent from all other streptococci, although a set of elements related to the pneumococcal BOX repeat was identified in the zoonotic pathogen S. suis. In conjunction with information regarding their distribution within the pneumococcal chromosome, this suggests that it is unlikely that these repeats are specialised sequences performing a particular role for the host, but rather that they constitute parasitic elements. However, comparing insertion sites between pneumococcal sequences indicates that they appear to transpose at a much lower rate than IS elements. Some large BOX elements in S. pneumoniae were found to encode open reading frames on both strands of the genome, whilst another was found to form a composite RNA structure with two T box riboswitches. In multiple cases, such BOX elements were demonstrated as being expressed using directional RNA-seq and RT-PCR. Conclusions BOX, RUP and SPRITE repeats appear to have proliferated extensively throughout the pneumococcal chromosome during the species' past, but novel insertions are currently occurring at a relatively slow rate. Through their extensive secondary structures, they seem likely to affect the expression of genes with which they are co-transcribed. Software for annotation of these repeats is freely available from ftp://ftp.sanger.ac.uk/pub/pathogens/strep_repeats/. PMID:21333003

UPDATED ANALYSIS OF THE UPWIND INTERPLANETARY HYDROGEN VELOCITY AS OBSERVED BY THE HUBBLE SPACE TELESCOPE DURING SOLAR CYCLE 23

International Nuclear Information System (INIS)

Vincent, Frederic E.; Ben-Jaffel, Lotfi; Harris, Walter M.

2011-01-01

The interplanetary hydrogen (IPH), a population of neutrals that fill the space between planets inside the heliosphere, carries the signature of the interstellar medium (ISM) and the heliospheric interface. As the incoming ISM-ionized component deflects at the heliopause, charge exchange reactions decelerate the bulk motion of the neutrals that penetrate the heliosphere. Inside the heliosphere, the IPH bulk velocity is further affected by solar gravity, radiation pressure, and ionization processes, with the latter two processes dependent on solar activity. Solar cycle 23 provided the first partial temporal map of the IPH velocity, including measurements from the Hubble Space Telescope (HST) spectrometers (Goddard High Resolution Spectrograph (GHRS) and Space Telescope Imaging Spectrograph (STIS)) and the Solar and Heliospheric Observatory/Solar Wind ANisotropies (SWAN) instrument. We present an updated analysis of IPH velocity measurements from GHRS and STIS and compare these results with those of SWAN and two different time-dependent models. Our reanalysis of STIS data reveals a significant change in IPH velocity relative to earlier reports, because of the contamination by geocoronal oxygen that was not accounted for. While current models of the heliospheric interface predict the observed IPH velocity for solar maximum, they are not consistent with data covering solar minimum. With updates to the HST data points, we now find that all data can be fit by the existing models to within 1σ, with the exception of SWAN observations taken at solar minimum (1997/1998). We conclude that the current data lack the temporal coverage and/or precision necessary to determine the detailed characteristics of the solar cycle dependence. Hence, new observations are merited.

Nonparametric additive regression for repeatedly measured data

KAUST Repository

Carroll, R. J.; Maity, A.; Mammen, E.; Yu, K.

2009-01-01

We develop an easily computed smooth backfitting algorithm for additive model fitting in repeated measures problems. Our methodology easily copes with various settings, such as when some covariates are the same over repeated response measurements

REPEATABILITY OF SPITZER/IRAC EXOPLANETARY ECLIPSES WITH INDEPENDENT COMPONENT ANALYSIS

Energy Technology Data Exchange (ETDEWEB)

Morello, G.; Waldmann, I. P.; Tinetti, G., E-mail: giuseppe.morello.11@ucl.ac.uk [Department of Physics and Astronomy, University College London, Gower Street, WC1E6BT (United Kingdom)

2016-04-01

The research of effective and reliable detrending methods for Spitzer data is of paramount importance for the characterization of exoplanetary atmospheres. To date, the totality of exoplanetary observations in the mid- and far-infrared, at wavelengths >3 μm, have been taken with Spitzer. In some cases, in past years, repeated observations and multiple reanalyses of the same data sets led to discrepant results, raising questions about the accuracy and reproducibility of such measurements. Morello et al. (2014, 2015) proposed a blind-source separation method based on the Independent Component Analysis of pixel time series (pixel-ICA) to analyze InfraRed Array Camera (IRAC) data, obtaining coherent results when applied to repeated transit observations previously debated in the literature. Here we introduce a variant to the pixel-ICA through the use of wavelet transform, wavelet pixel-ICA, which extends its applicability to low-signal-to-noise-ratio cases. We describe the method and discuss the results obtained over 12 eclipses of the exoplanet XO3b observed during the “Warm Spitzer” era in the 4.5 μm band. The final results are reported, in part, also in Ingalls et al. (2016), together with results obtained with other detrending methods, and over 10 synthetic eclipses that were analyzed for the “IRAC Data Challenge 2015.” Our results are consistent within 1σ with the ones reported in Wong et al. (2014) and with most of the results reported in Ingalls et al. (2016), which appeared on arXiv while this paper was under review. Based on many statistical tests discussed in Ingalls et al. (2016), the wavelet pixel-ICA method performs as well as or better than other state-of-art methods recently developed by other teams to analyze Spitzer/IRAC data, and, in particular, it appears to be the most repeatable and the most reliable, while reaching the photon noise limit, at least for the particular data set analyzed. Another strength of the ICA approach is its highest

REPEATABILITY OF SPITZER/IRAC EXOPLANETARY ECLIPSES WITH INDEPENDENT COMPONENT ANALYSIS

International Nuclear Information System (INIS)

Morello, G.; Waldmann, I. P.; Tinetti, G.

2016-01-01

The research of effective and reliable detrending methods for Spitzer data is of paramount importance for the characterization of exoplanetary atmospheres. To date, the totality of exoplanetary observations in the mid- and far-infrared, at wavelengths >3 μm, have been taken with Spitzer. In some cases, in past years, repeated observations and multiple reanalyses of the same data sets led to discrepant results, raising questions about the accuracy and reproducibility of such measurements. Morello et al. (2014, 2015) proposed a blind-source separation method based on the Independent Component Analysis of pixel time series (pixel-ICA) to analyze InfraRed Array Camera (IRAC) data, obtaining coherent results when applied to repeated transit observations previously debated in the literature. Here we introduce a variant to the pixel-ICA through the use of wavelet transform, wavelet pixel-ICA, which extends its applicability to low-signal-to-noise-ratio cases. We describe the method and discuss the results obtained over 12 eclipses of the exoplanet XO3b observed during the “Warm Spitzer” era in the 4.5 μm band. The final results are reported, in part, also in Ingalls et al. (2016), together with results obtained with other detrending methods, and over 10 synthetic eclipses that were analyzed for the “IRAC Data Challenge 2015.” Our results are consistent within 1σ with the ones reported in Wong et al. (2014) and with most of the results reported in Ingalls et al. (2016), which appeared on arXiv while this paper was under review. Based on many statistical tests discussed in Ingalls et al. (2016), the wavelet pixel-ICA method performs as well as or better than other state-of-art methods recently developed by other teams to analyze Spitzer/IRAC data, and, in particular, it appears to be the most repeatable and the most reliable, while reaching the photon noise limit, at least for the particular data set analyzed. Another strength of the ICA approach is its highest

Quantum key distribution with two-segment quantum repeaters

Energy Technology Data Exchange (ETDEWEB)

Kampermann, Hermann; Abruzzo, Silvestre; Bruss, Dagmar [Theoretische Physik III, Heinrich-Heine-Universitaet Duesseldorf (Germany)

2014-07-01

Quantum repeaters represent one possible way to achieve long-distance quantum key distribution. One way of improving the repeater rate and decreasing the memory coherence time is the usage of multiplexing. Motivated by the experimental fact that long-range connections are practically demanding, we extend the analysis of the quantum repeater multiplexing protocol to the case of short-range connections. We derive formulas for the repeater rate and we show that short-range connections lead to most of the benefits of a full-range multiplexing protocol. A less demanding QKD-protocol without quantum memories was recently introduced by Lo et al. We generalize this measurement-device-independent quantum key Distribution protocol to the scenario where the repeater Station contains also heralded quantum memories. We assume either single-photon sources or weak coherent pulse sources plus decay states. We show that it is possible to significantly outperform the original proposal, even in presence of decoherence of the quantum memory. We give formulas in terms of device imperfections i.e., the quantum bit error rate and the repeater rate.

The Impact of Repeated Freeze-Thaw Cycles on the Quality of Biomolecules in Four Different Tissues.

Science.gov (United States)

Ji, Xiaoli; Wang, Min; Li, Lingling; Chen, Fang; Zhang, Yanyang; Li, Qian; Zhou, Junmei

2017-10-01

High-quality biosamples are valuable resources for biomedical research. However, some tissues are stored without being sectioned into small aliquots and have to undergo repeated freeze-thaw cycles throughout prolonged experimentation. Little is known regarding the effects of repeated freeze-thaw cycles on the quality of biomolecules in tissues. The aim of this study was to evaluate the impact of repeated freeze-thaw (at room temperature or on ice) cycles on biomolecules and gene expression in four different types of tissues. Each fresh tissue was sectioned into seven aliquots and snap-frozen before undergoing repeated freeze-thaw cycles at room temperature or on ice. Biomolecules were extracted and analyzed. Both relative and absolute quantification were used to detect the changes in gene expression. The results indicated that the impact of repeated freeze-thaw cycles on RNA integrity varied by tissue type. Gene expression, including the housekeeping gene, was affected in RNA-degraded samples according to absolute quantification rather than relative quantification. Furthermore, our results suggest that thawing on ice could protect RNA integrity compared with thawing at room temperature. No obvious degradation of protein or DNA was observed with repeated freeze-thaw cycles either at room temperature or on ice. This research provides ample evidence for the necessity of sectioning fresh tissues into small aliquots before snap-freezing, thus avoiding degradation of RNA and alteration of gene expression resulting from repeated freeze-thaw cycles. For frozen tissue samples that were already in storage and had to be used repeatedly during their lifecycle, thawing on ice or sectioned at ultralow temperature is recommended.

Negative differential mobility for negative carriers as revealed by space charge measurements on crosslinked polyethylene insulated model cables

Energy Technology Data Exchange (ETDEWEB)

Teyssedre, G., E-mail: gilbert.teyssedre@laplace.univ-tlse.fr; Laurent, C. [Université de Toulouse, UPS, INPT, LAPLACE (Laboratoire Plasma et Conversion d' Energie), 118 route de Narbonne, F-31062 Toulouse cedex 9 (France); CNRS, LAPLACE, F-31062 Toulouse (France); Vu, T. T. N. [Université de Toulouse, UPS, INPT, LAPLACE (Laboratoire Plasma et Conversion d' Energie), 118 route de Narbonne, F-31062 Toulouse cedex 9 (France); Electric Power University, 235 Hoang Quoc Viet, 10000 Hanoi (Viet Nam)

2015-12-21

Among features observed in polyethylene materials under relatively high field, space charge packets, consisting in a pulse of net charge that remains in the form of a pulse as it crosses the insulation, are repeatedly observed but without complete theory explaining their formation and propagation. Positive charge packets are more often reported, and the models based on negative differential mobility(NDM) for the transport of holes could account for some charge packets phenomenology. Conversely, NDM for electrons transport has never been reported so far. The present contribution reports space charge measurements by pulsed electroacoustic method on miniature cables that are model of HVDC cables. The measurements were realized at room temperature or with a temperature gradient of 10 °C through the insulation under DC fields on the order 30–60 kV/mm. Space charge results reveal systematic occurrence of a negative front of charges generated at the inner electrode that moves toward the outer electrode at the beginning of the polarization step. It is observed that the transit time of the front of negative charge increases, and therefore the mobility decreases, with the applied voltage. Further, the estimated mobility, in the range 10{sup −14}–10{sup −13} m{sup 2} V{sup −1} s{sup −1} for the present results, increases when the temperature increases for the same condition of applied voltage. The features substantiate the hypothesis of negative differential mobility used for modelling space charge packets.

Partially Observable Markov Decision Process-Based Transmission Policy over Ka-Band Channels for Space Information Networks

Directory of Open Access Journals (Sweden)

Jian Jiao

2017-09-01

Full Text Available The Ka-band and higher Q/V band channels can provide an appealing capacity for the future deep-space communications and Space Information Networks (SIN, which are viewed as a primary solution to satisfy the increasing demands for high data rate services. However, Ka-band channel is much more sensitive to the weather conditions than the conventional communication channels. Moreover, due to the huge distance and long propagation delay in SINs, the transmitter can only obtain delayed Channel State Information (CSI from feedback. In this paper, the noise temperature of time-varying rain attenuation at Ka-band channels is modeled to a two-state Gilbert–Elliot channel, to capture the channel capacity that randomly ranging from good to bad state. An optimal transmission scheme based on Partially Observable Markov Decision Processes (POMDP is proposed, and the key thresholds for selecting the optimal transmission method in the SIN communications are derived. Simulation results show that our proposed scheme can effectively improve the throughput.

Application of Observing System Simulation Experiments (OSSEs) to determining science and user requirements for space-based missions

Science.gov (United States)

Atlas, R. M.

2016-12-01

Observing System Simulation Experiments (OSSEs) provide an effective method for evaluating the potential impact of proposed new observing systems, as well as for evaluating trade-offs in observing system design, and in developing and assessing improved methodology for assimilating new observations. As such, OSSEs can be an important tool for determining science and user requirements, and for incorporating these requirements into the planning for future missions. Detailed OSSEs have been conducted at NASA/ GSFC and NOAA/AOML in collaboration with Simpson Weather Associates and operational data assimilation centers over the last three decades. These OSSEs determined correctly the quantitative potential for several proposed satellite observing systems to improve weather analysis and prediction prior to their launch, evaluated trade-offs in orbits, coverage and accuracy for space-based wind lidars, and were used in the development of the methodology that led to the first beneficial impacts of satellite surface winds on numerical weather prediction. In this talk, the speaker will summarize the development of OSSE methodology, early and current applications of OSSEs and how OSSEs will evolve in order to enhance mission planning.

An Astrosocial Observation: The Nobel Connection to the Space Program

Science.gov (United States)

Ng, Edward W.; Nash, Rebecca L.

2007-01-01

The 2006 Nobel Prize in Physics was heralded by some in the press as the 'First Nobel Prize for Space Exploration.' Indeed the Nobel Foundation's announcement specifically cited the Cosmic Background Explorer (COBE) satellite launched by NASA in 1989 as the prime-enabling instrument It elaborated further, 'The COBE results provided increased support for the Big Bang scenario for the origin of the Universe... These measurements also marked the inception of cosmology as a precise science.' NASA also seized this unique moment of fame to honor its favorite son, the first Nobel scientist of the agency, John Mather, of the Goddard Space Flight Center, who shared the honor with Professor G. Smoot of the University of California, the Principal Investigator of the COBE measurement. It is without any dispute that the Nobel Prize is the highest scientific honor and best-known award of admiration and inspiration to the public and educational sectors. Unfortunately in the American culture, youths are mostly exposed to success icons in the sports, entertainment, and business domains. Science icons (of either gender) are largely unknown to them. We sincerely hope that success stories of Nobel scientists will become part of the learning curriculum in the K-16 educational experience. In this paper, we examine the pedigree of a number of Nobel Prizes over the years, and discuss their interactions with, and connections to, the space program. It is advantageous for the context of educational and public outreach to see such connections, because in a number of public surveys, one important customer expectation for the space program is the search for new knowledge, to which the Nobel Prize is a prominent benchmark.

Double layers in space

International Nuclear Information System (INIS)

Carlqvist, P.

1982-07-01

For more than a decade it has been realised that electrostatic double layers are likely to occur in space. We briefly discuss the theoretical background of such double layers. Most of the paper is devoted to an account of the observational evidence for double layers in the ionosphere and magnetosphere of the Earth. Several different experiments are reviewed including rocket and satellite measurements and ground based observations. It is concluded that the observational evidence for double layers in space is very strong. The experimental results indicate that double layers with widely different properties may exist in space. (Author)

Double layers in space

International Nuclear Information System (INIS)

Carlqvist, P.

1982-01-01

For more than a decade it has been realised that electrostatic double layers are likely to occur in space. The author briefly discusses the theoretical background of such double layers. Most of the paper is devoted to an account of the observational evidence for double layers in the ionosphere and magnetosphere of the Earth. Several different experiments are reviewed including rocket and satellite measurements and ground based observations. It is concluded that the observational evidence for double layers in space is very strong. The experimental results indicate that double layers with widely different properties may exist in space. (Auth.)

Deployment Repeatability

Science.gov (United States)

2016-08-31

large cohort of trials to spot unusual cases. However, deployment repeatability is inherently a nonlinear phenomenon, which makes modeling difficult...and GEMS tip position were both tracked during ground testing by a laser target tracking system. Earlier SAILMAST testing in 2005 [8] used...recalls the strategy used by SRTM, where a constellation of lights was installed at the tip of the boom and a modified star tracker was used to track tip

Sleep-effects on implicit and explicit memory in repeated visual search.

Science.gov (United States)

Geyer, Thomas; Mueller, Hermann J; Assumpcao, Leonardo; Gais, Steffen

2013-01-01

In repeated visual search tasks, facilitation of reaction times (RTs) due to repetition of the spatial arrangement of items occurs independently of RT facilitation due to improvements in general task performance. Whereas the latter represents typical procedural learning, the former is a kind of implicit memory that depends on the medial temporal lobe (MTL) memory system and is impaired in patients with amnesia. A third type of memory that develops during visual search is the observers' explicit knowledge of repeated displays. Here, we used a visual search task to investigate whether procedural memory, implicit contextual cueing, and explicit knowledge of repeated configurations, which all arise independently from the same set of stimuli, are influenced by sleep. Observers participated in two experimental sessions, separated by either a nap or a controlled rest period. In each of the two sessions, they performed a visual search task in combination with an explicit recognition task. We found that (1) across sessions, MTL-independent procedural learning was more pronounced for the nap than rest group. This confirms earlier findings, albeit from different motor and perceptual tasks, showing that procedural memory can benefit from sleep. (2) Likewise, the sleep group compared with the rest group showed enhanced context-dependent configural learning in the second session. This is a novel finding, indicating that the MTL-dependent, implicit memory underlying contextual cueing is also sleep-dependent. (3) By contrast, sleep and wake groups displayed equivalent improvements in explicit recognition memory in the second session. Overall, the current study shows that sleep affects MTL-dependent as well as MTL-independent memory, but it affects different, albeit simultaneously acquired, forms of MTL-dependent memory differentially.

Observer-dependent quantum vacua in curved space

International Nuclear Information System (INIS)

Castagnino, M.; Ferraro, R.

1986-01-01

An observer-dependent Hamiltonian is introduced. The vacuum state is defined by means of Hamiltonian diagonalization and minimization, which result to be equivalent criteria. This method encompasses a great number of known vacuum definitions, and works in an arbitrary geometry if the observer's field satisfies certain properties

Numerical Identification of Multiparameters in the Space Fractional Advection Dispersion Equation by Final Observations

Directory of Open Access Journals (Sweden)

Dali Zhang

2012-01-01

Full Text Available This paper deals with an inverse problem for identifying multiparameters in 1D space fractional advection dispersion equation (FADE on a finite domain with final observations. The parameters to be identified are the fractional order, the diffusion coefficient, and the average velocity in the FADE. The forward problem is solved by a finite difference scheme, and then an optimal perturbation regularization algorithm is introduced to determine the three parameters simultaneously. Numerical inversions are performed both with the accurate data and noisy data, and several factors having influences on realization of the algorithm are discussed. The inversion solutions are in good approximations to the exact solutions demonstrating the efficiency of the proposed algorithm.

R-loops: targets for nuclease cleavage and repeat instability.

Science.gov (United States)

Freudenreich, Catherine H

2018-01-11

R-loops form when transcribed RNA remains bound to its DNA template to form a stable RNA:DNA hybrid. Stable R-loops form when the RNA is purine-rich, and are further stabilized by DNA secondary structures on the non-template strand. Interestingly, many expandable and disease-causing repeat sequences form stable R-loops, and R-loops can contribute to repeat instability. Repeat expansions are responsible for multiple neurodegenerative diseases, including Huntington's disease, myotonic dystrophy, and several types of ataxias. Recently, it was found that R-loops at an expanded CAG/CTG repeat tract cause DNA breaks as well as repeat instability (Su and Freudenreich, Proc Natl Acad Sci USA 114, E8392-E8401, 2017). Two factors were identified as causing R-loop-dependent breaks at CAG/CTG tracts: deamination of cytosines and the MutLγ (Mlh1-Mlh3) endonuclease, defining two new mechanisms for how R-loops can generate DNA breaks (Su and Freudenreich, Proc Natl Acad Sci USA 114, E8392-E8401, 2017). Following R-loop-dependent nicking, base excision repair resulted in repeat instability. These results have implications for human repeat expansion diseases and provide a paradigm for how RNA:DNA hybrids can cause genome instability at structure-forming DNA sequences. This perspective summarizes mechanisms of R-loop-induced fragility at G-rich repeats and new links between DNA breaks and repeat instability.

Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions.

Science.gov (United States)

Weaver, James L; Tobin, Grainne A; Ingle, Taylor; Bancos, Simona; Stevens, David; Rouse, Rodney; Howard, Kristina E; Goodwin, David; Knapton, Alan; Li, Xiaohong; Shea, Katherine; Stewart, Sharron; Xu, Lin; Goering, Peter L; Zhang, Qin; Howard, Paul C; Collins, Jessie; Khan, Saeed; Sung, Kidon; Tyner, Katherine M

2017-07-17

As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study was designed to evaluate whether gold (10 nm), silver (50 nm), or silica (10 nm) nanoparticles administered intravenously to mice for up to 8 weeks at doses known to be sub-toxic (non-toxic at single acute or repeat dosing levels) and clinically relevant could produce significant bioaccumulation in liver and spleen macrophages. Repeated dosing with gold, silver, and silica nanoparticles did not saturate bioaccumulation in liver or spleen macrophages. While no toxicity was observed with gold and silver nanoparticles throughout the 8 week experiment, some effects including histopathological and serum chemistry changes were observed with silica nanoparticles starting at week 3. No major changes in the splenocyte population were observed during the study for any of the nanoparticles tested. The clinical impact of these changes is unclear but suggests that the mononuclear phagocytic system is able to handle repeated doses of nanoparticles.

Repeat profile analysis in an x-ray department

International Nuclear Information System (INIS)

Bassey, C.E.; Ojo, O.O.; Akpabio, I.

1991-01-01

The repeat profile of an x-ray department in a developing country was analysed monthly between July 1989 and June 1990. Results showed an average repeat rate of 3.7% for the period of study. The main causes of film repetition were: equipment fault, 33.9%; radiographer's fault, 27.4%; film fault, 19.3%; processing fault, 10.8% and patient's fault, 8.6%. The average repeat rate in the first 6 months of study reduced by 50% in the last 6 months. This was due to the effectiveness of implementation of corrective actions. The overall repeat rate was found to correlate well with both the equipment fault and radiographer's fault with correlation coefficients, r, of 0.94 and 0.91, respectively. It is expected that a further reduction in the repeat rate will be obtained after the introduction of quality assurance programmes. (author)

PHOTOMETRIC OBSERVATIONS OF SELECTED, OPTICALLY BRIGHT QUASARS FOR SPACE INTERFEROMETRY MISSION AND OTHER FUTURE CELESTIAL REFERENCE FRAMES

International Nuclear Information System (INIS)

Ojha, Roopesh; Zacharias, Norbert; Hennessy, Gregory S.; Gaume, Ralph A.; Johnston, Kenneth J.

2009-01-01

Photometric observations of 235 extragalactic objects that are potential targets for the Space Interferometry Mission (SIM) are presented. Mean B, V, R, I magnitudes at the 5% level are obtained at 1-4 epochs between 2005 and 2007 using the 1 m telescopes at Cerro Tololo Inter-American Observatory and the Naval Observatory Flagstaff Station. Of the 134 sources that have V magnitudes in the Veron and Veron-Cetty catalog, a difference of over 1.0 mag is found for the observed-catalog magnitudes for about 36% of the common sources, and 10 sources show over 3 mag difference. Our first set of observations presented here form the basis of a long-term photometric variability study of the selected reference frame sources to assist in mission target selection and to support QSO multicolor photometric variability studies in general.

An Approach to Assess Observation Impact Based on Observation-Minus-Forecast Residuals

Science.gov (United States)

Todling, Ricardo

2009-01-01

Langland and Baker (2004) introduced an approach to assess the impact of observations on the forecasts. In that, a state-space aspect of the forecast is defined and a procedure is derived that relates changes in the aspect with changes in the initial conditions associated with the assimilation of observations) ultimately providing information about the impact of individual observations on the forecast. Some features of the approach are to be noted. The typical choice of forecast aspect employed in related works is rather arbitrary and leads to an incomplete assessment of the observing system. Furthermore, the state-space forecast aspect requires availability of a verification state that should ideally be uncorrelated with the forecast but in practice is not. Lastly, the approach involves the adjoint operator of the entire data assimilation system and as such it is constrained by the validity of this operator. In this presentation, an observation-space metric is used that, for a relatively time-homogeneous observing system, allows inferring observation impact on the forecast without some of the limitations above. Specifically, using observation-minus-forecast residuals leads to an approach with the following features: (i) it suggests a rather natural choice of forecast aspect, directly linked to the analysis system and providing full assessment of the observations; (ii) it naturally avoids introducing undesirable correlations in the forecast aspect by verifying against the observations; and (iii) it does not involve linearization and use of adjoints; therefore being applicable to any length of forecast. The state and observation-space approaches might be complementary to some degree, and involve different limitations and complexities. Illustrations are given using the NASA GEOS-5 data.

The Global-Scale Observations of the Limb and Disk (GOLD) Mission

Science.gov (United States)

Eastes, R. W.; McClintock, W. E.; Burns, A. G.; Anderson, D. N.; Andersson, L.; Codrescu, M.; Correira, J. T.; Daniell, R. E.; England, S. L.; Evans, J. S.; Harvey, J.; Krywonos, A.; Lumpe, J. D.; Richmond, A. D.; Rusch, D. W.; Siegmund, O.; Solomon, S. C.; Strickland, D. J.; Woods, T. N.; Aksnes, A.; Budzien, S. A.; Dymond, K. F.; Eparvier, F. G.; Martinis, C. R.; Oberheide, J.

2017-10-01

The Earth's thermosphere and ionosphere constitute a dynamic system that varies daily in response to energy inputs from above and from below. This system can exhibit a significant response within an hour to changes in those inputs, as plasma and fluid processes compete to control its temperature, composition, and structure. Within this system, short wavelength solar radiation and charged particles from the magnetosphere deposit energy, and waves propagating from the lower atmosphere dissipate. Understanding the global-scale response of the thermosphere-ionosphere ( T-I) system to these drivers is essential to advancing our physical understanding of coupling between the space environment and the Earth's atmosphere. Previous missions have successfully determined how the "climate" of the T-I system responds. The Global-scale Observations of the Limb and Disk (GOLD) mission will determine how the "weather" of the T-I responds, taking the next step in understanding the coupling between the space environment and the Earth's atmosphere. Operating in geostationary orbit, the GOLD imaging spectrograph will measure the Earth's emissions from 132 to 162 nm. These measurements will be used image two critical variables—thermospheric temperature and composition, near 160 km—on the dayside disk at half-hour time scales. At night they will be used to image the evolution of the low latitude ionosphere in the same regions that were observed earlier during the day. Due to the geostationary orbit being used the mission observes the same hemisphere repeatedly, allowing the unambiguous separation of spatial and temporal variability over the Americas.

Research Opportunities on board Virgin Galactic's SpaceShipTwo

Science.gov (United States)

Attenborough, S.; Pomerantz, W.; Stephens, K.

2013-09-01

Virgin Galactic is building the world's first commercial spaceline. Our suborbital spaceflight system, pictured in Figure 1, consists of two vehicles: WhiteKnightTwo (WK2) and SpaceShipTwo (SS2). WhiteKnightTwo is a four-engine, dual-fuselage jet aircraft capable of high-altitude heavy lift missions, including, but not limited to fulfilling its role as a mothership for SpaceShipTwo, an air-launched, suborbital spaceplane capable of routinely reaching an apogee up to 110 kilometers. In conjunction, these two vehicles allow access to space and to regions of the atmosphere ranging from the troposphere to the thermosphere; additionally, they provide extended periods of microgravity in a reliable and affordable way. SpaceShipTwo, with a payload capacity of up to 1,300 lbs. (~600 kg), features payload mounting interfaces that are compatible with standard architectures such as NASA Space Shuttle Middeck Lockers, Cargo Transfer Bags, and server racks, in addition to custom structures. With the standard interface, payloads are allowed access to the large 17 inch diameter cabin windows for external observations. Each dedicated research flight will be accompanied by a Virgin Galactic Flight Test Engineer, providing an opportunity for limited in-flight interaction. In addition, tended payloads - a flight that includes the researcher and his or her payload - are also an option. At a price point that is highly competitive with parabolic aircraft and sounding rockets and significantly cheaper than orbital flights, SpaceShipTwo is a unique platform that can provide frequent and repeatable research opportunities. Suborbital flights on SpaceShipTwo offer researchers several minutes of microgravity time and views of the external environment in the upper atmosphere and in outer space. In addition to serving as an important research platform in and of itself, SpaceShipTwo also offers researchers a means to test, iterate, and calibrate experiments designed for orbital platforms

Androgen receptor CAG repeat polymorphism and epigenetic influence among the south Indian women with Polycystic Ovary Syndrome.

Directory of Open Access Journals (Sweden)

Shilpi Dasgupta

Full Text Available The present study was carried out to assess the role of androgen receptor CAG repeat polymorphism and X chromosome inactivation (XCI pattern among Indian PCOS women and controls which has not been hitherto explored and also to test the hypothesis that shorter CAG alleles would be preferentially activated in PCOS. CAG repeat polymorphism and X chromosome methylation patterns were compared between PCOS and non-PCOS women. 250 PCOS women and 299 controls were included for this study. Androgen receptor CAG repeat sizes, XCI percentages, and clinical and biochemical parameters were measured. The mean CAG repeat number is similar between the cases (18.74±0.13 and controls (18.73±0.12. The obese PCOS women were significantly more frequent in the 20 CAG repeat category than the lean PCOS women, yielding a highly significant odds (p=0.001. Among the women with non-random X-inactivation, alleles with <19 repeats were more frequently activated among cases than controls (p=0.33. CAG repeat polymorphism by itself cannot be considered as a useful marker for discriminating PCOS. We observed a trend of preferential activation of the shorter allele among the PCOS cases with non random XCI pattern. In the obese PCOS women, this microsatellite variation may account for the hyperandrogenicity to a larger extent than the lean PCOS women.

The Global Geodetic Observing System: Space Geodesy Networks for the Future

Science.gov (United States)

Pearlman, Michael; Pavlis, Erricos; Ma, Chopo; Altamini, Zuheir; Noll, Carey; Stowers, David

2011-01-01

Ground-based networks of co-located space geodetic techniques (VLBI, SLR, GNSS. and DORIS) are the basis for the development and maintenance of the International Terrestrial Reference frame (ITRF), which is our metric of reference for measurements of global change, The Global Geodetic Observing System (GGOS) of the International Association of Geodesy (IAG) has established a task to develop a strategy to design, integrate and maintain the fundamental geodetic network and supporting infrastructure in a sustainable way to satisfy the long-term requirements for the reference frame. The GGOS goal is an origin definition at 1 mm or better and a temporal stability on the order of 0.1 mm/y, with similar numbers for the scale and orientation components. These goals are based on scientific requirements to address sea level rise with confidence, but other applications are not far behind. Recent studies including one by the US National Research Council has strongly stated the need and the urgency for the fundamental space geodesy network. Simulations are underway to examining accuracies for origin, scale and orientation of the resulting ITRF based on various network designs and system performance to determine the optimal global network to achieve this goal. To date these simulations indicate that 24 - 32 co-located stations are adequate to define the reference frame and a more dense GNSS and DORIS network will be required to distribute the reference frame to users anywhere on Earth. Stations in the new global network will require geologically stable sites with good weather, established infrastructure, and local support and personnel. GGOS wil seek groups that are interested in participation. GGOS intends to issues a Call for Participation of groups that would like to contribute in the network implementation and operation. Some examples of integrated stations currently in operation or under development will be presented. We will examine necessary conditions and challenges in

Accuracy and repeatability of quantitative fluoroscopy for the measurement of sagittal plane translation and finite centre of rotation in the lumbar spine.

Science.gov (United States)

Breen, Alexander; Breen, Alan

2016-07-01

Quantitative fluoroscopy (QF) was developed to measure intervertebral mechanics in vivo and has been found to have high repeatability and accuracy for the measurement of intervertebral rotations. However, sagittal plane translation and finite centre of rotation (FCR) are potential measures of stability but have not yet been fully validated for current QF. This study investigated the repeatability and accuracy of QF for measuring these variables. Repeatability was assessed from L2-S1 in 20 human volunteers. Accuracy was investigated using 10 consecutive measurements from each of two pairs of linked and instrumented dry human vertebrae as reference; one which tilted without translation and one which translated without tilt. The results found intra- and inter-observer repeatability for translation to be 1.1mm or less (SEM) with fair to substantial reliability (ICC 0.533-0.998). Intra-observer repeatability of FCR location for inter-vertebral rotations of 5° and above ranged from 1.5mm to 1.8mm (SEM) with moderate to substantial reliability (ICC 0.626-0.988). Inter-observer repeatability for FCR ranged from 1.2mm to 5.7mm, also with moderate to substantial reliability (ICC 0.621-0.878). Reliability was substantial (ICC>0.81) for 10/16 measures for translation and 5/8 for FCR location. Accuracy for translation was 0.1mm (fixed centre) and 2.2mm (moveable centre), with an FCR error of 0.3mm(x) and 0.4mm(y) (fixed centre). This technology was found to have a high level of accuracy and with a few exceptions, moderate to substantial repeatability for the measurement of translation and FCR from fluoroscopic motion sequences. Copyright © 2016 IPEM. Published by Elsevier Ltd. All rights reserved.

Ultrasonic detection of spall damage nucleation under low-velocity repeated impact

Directory of Open Access Journals (Sweden)

Watanabe T.

2012-08-01

Full Text Available Repeated plate impact testing with impact stress well below the threshold spall-stress (2.6 GPa on medium carbon steel was carried out to the identical target plate by impacting the flyer plate. Occurrence of spall damage under low-velocity repeated impact was evaluated nondestructively with a low frequency scanning acoustic microscope. We observed the spall damage distribution by the B- and C-scan images. In order to initiate the spall damage (voids in a ductile material or cracks in a brittle one the particular value of threshold spall-stress should be exceeded what already belongs to a commonly accepted knowledge. Generally, the spall damage development is dependent on the amplitude and the duration of the stress pulse. If the stress is high and duration is long enough to create tensile failure of material, the voids or cracks nucleate along the spall plane, and consequently, they form macrocracks. Therefore, the spall damage does not create when the first impact stress is less than the threshold spall-stress. However, after the fifth low-velocity repeated impact test, the generation of the spall damage was detected, even if the impact stress (1.1–1.7 GPa was lower than the threshold spall-stress (2.6 GPa.

Ten days of repeated local forearm heating does not affect cutaneous vascular function.

Science.gov (United States)

Francisco, Michael A; Brunt, Vienna E; Jensen, Krista Nicole; Lorenzo, Santiago; Minson, Christopher T

2017-08-01

The aim of the present study was to determine whether 10 days of repeated local heating could induce peripheral adaptations in the cutaneous vasculature and to investigate potential mechanisms of adaptation. We also assessed maximal forearm blood flow to determine whether repeated local heating affects maximal dilator capacity. Before and after 10 days of heat training consisting of 1-h exposures of the forearm to 42°C water or 32°C water (control) in the contralateral arm (randomized and counterbalanced), we assessed hyperemia to rapid local heating of the skin ( n = 14 recreationally active young subjects). In addition, sequential doses of acetylcholine (ACh, 1 and 10 mM) were infused in a subset of subjects ( n = 7) via microdialysis to study potential nonthermal microvascular adaptations following 10 days of repeated forearm heat training. Skin blood flow was assessed using laser-Doppler flowmetry, and cutaneous vascular conductance (CVC) was calculated as laser-Doppler red blood cell flux divided by mean arterial pressure. Maximal cutaneous vasodilation was achieved by heating the arm in a water-spray device for 45 min and assessed using venous occlusion plethysmography. Forearm vascular conductance (FVC) was calculated as forearm blood flow divided by mean arterial pressure. Repeated forearm heating did not increase plateau percent maximal CVC (CVC max ) responses to local heating (89 ± 3 vs. 89 ± 2% CVC max , P = 0.19), 1 mM ACh (43 ± 9 vs. 53 ± 7% CVC max , P = 0.76), or 10 mM ACh (61 ± 9 vs. 85 ± 7% CVC max , P = 0.37, by 2-way repeated-measures ANOVA). There was a main effect of time at 10 mM ACh ( P = 0.03). Maximal FVC remained unchanged (0.12 ± 0.02 vs. 0.14 ± 0.02 FVC, P = 0.30). No differences were observed in the control arm. Ten days of repeated forearm heating in recreationally active young adults did not improve the microvascular responsiveness to ACh or local heating. NEW & NOTEWORTHY We show for the first time that 10 days of repeated

Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: an observation based on arsenic-exposed individuals.

Science.gov (United States)

Wu, Meei-Maan; Chiou, Hung-Yi; Chen, Chi-Ling; Hsu, Ling-I; Lien, Li-Ming; Wang, Chih-Hao; Hsieh, Yi-Chen; Wang, Yuan-Hung; Hsueh, Yu-Mei; Lee, Te-Chang; Cheng, Wen-Fang; Chen, Chien-Jen

2011-12-01

Heme oxygenase (HO)-1 is up-regulated as a cellular defense responding to stressful stimuli in experimental studies. A GT-repeat length polymorphism in the HO-1 gene promoter was inversely correlated to HO-1 induction. Here, we reported the association of GT-repeat polymorphism with blood pressure (BP) phenotypes, and their interaction on cardiovascular (CV) mortality risk in arsenic-exposed cohorts. Associations of GT-repeat polymorphism with BP phenotypes were investigated at baseline in a cross-sectional design. Effect of GT-repeat polymorphism on CV mortality was investigated in a longitudinal design stratified by hypertension. GT-repeat variants were grouped by S (accounting for CV covariates. Totally, 894 participants were recruited and analyzed. At baseline, carriers with HO-1 S alleles had lower diastolic BP (L/S genotypes, P = 0.014) and a lower possibility of being hypertensive (L/S genotypes, P = 0.048). After follow-up, HO-1 S allele was significantly associated with a reduced CV risk in hypertensive participants [relative mortality ratio (RMR) 0.27 (CI 0.11, 0.69), P = 0.007] but not in normotensive. Hypertensive participants without carrying the S allele had a 5.23-fold increased risk [RMR 5.23 (CI 1.99, 13.69), P = 0.0008] of CV mortality compared with normotensive carrying the S alleles. HO-1 short GT-repeat polymorphism may play a protective role in BP regulation and CV mortality risk in hypertensive individuals against environmental stressors. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Development of analog watch with minute repeater

Science.gov (United States)

Okigami, Tomio; Aoyama, Shigeru; Osa, Takashi; Igarashi, Kiyotaka; Ikegami, Tomomi

A complementary metal oxide semiconductor with large scale integration was developed for an electronic minute repeater. It is equipped with the synthetic struck sound circuit to generate natural struck sound necessary for the minute repeater. This circuit consists of an envelope curve drawing circuit, frequency mixer, polyphonic mixer, and booster circuit made by using analog circuit technology. This large scale integration is a single chip microcomputer with motor drivers and input ports in addition to the synthetic struck sound circuit, and it is possible to make an electronic system of minute repeater at a very low cost in comparison with the conventional type.

Repeatability and comparison of clinical techniques for anterior chamber angle assessment.

Science.gov (United States)

Campbell, Peter; Redmond, Tony; Agarwal, Rishi; Marshall, Lewis R; Evans, Bruce J W

2015-03-01

To assess the repeatability of gonioscopy, van Herick method and anterior segment Optical Coherence Tomography (AS-OCT) and determine the agreement between these techniques within a community optometry setting. Gonioscopy, van Herick method and AS-OCT imaging were performed by an optometrist on two occasions, 1 month apart, on 80 subjects aged over 40 years recruited from community optometry practices. Anterior segment images were captured with a spectral domain OCT (Topcon 3D OCT-2000; wavelength 840 nm) set to the Anterior Segment (AS) mode. Eyes were graded as open or occludable for each method. AS-OCT images from both visits were graded by a second optometrist masked to the gonioscopy and van Herick method results, and the visit on which the images were acquired. Cohen's kappa (κ) was used to describe the intra-observer repeatability. Likelihood ratios, sensitivity and specificity of van Herick method and AS-OCT were calculated, using gonioscopy as the reference standard. Measurements were obtained from 80 eyes of 80 subjects. In four cases, AS-OCT images were un-gradable due to difficulty in locating the scleral spur. The repeatability of gonioscopy was fair κ = 0.29, while that of the van Herick method (κ = 0.54) and AS-OCT (κ = 0.47) were somewhat better. The van Herick method showed good sensitivity (visit 1: 75%, visit 2: 69%) and high specificity (visit 1: 88%, visit 2: 96%). The sensitivity of AS-OCT was fair (visit 1: 46%, visit 2: 25%), but specificity was high (visit 1: 87%. visit 2: 89%). Intra-observer repeatability was better for van Herick method and for AS-OCT than for gonioscopy, despite the latter being considered the gold standard method. The van Herick method appeared to be more sensitive than AS-OCT when identifying eyes at risk of angle closure. A standalone anterior segment OCT with a longer wavelength laser could afford better visualisation of the angle, and might therefore be expected to enable the examiner to make more

RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility

Directory of Open Access Journals (Sweden)

Aisling Frizzell

2014-03-01

Full Text Available Human RTEL1 is an essential, multifunctional helicase that maintains telomeres, regulates homologous recombination, and helps prevent bone marrow failure. Here, we show that RTEL1 also blocks trinucleotide repeat expansions, the causal mutation for 17 neurological diseases. Increased expansion frequencies of (CTG⋅CAG repeats occurred in human cells following knockdown of RTEL1, but not the alternative helicase Fbh1, and purified RTEL1 efficiently unwound triplet repeat hairpins in vitro. The expansion-blocking activity of RTEL1 also required Rad18 and HLTF, homologs of yeast Rad18 and Rad5. These findings are reminiscent of budding yeast Srs2, which inhibits expansions, unwinds hairpins, and prevents triplet-repeat-induced chromosome fragility. Accordingly, we found expansions and fragility were suppressed in yeast srs2 mutants expressing RTEL1, but not Fbh1. We propose that RTEL1 serves as a human analog of Srs2 to inhibit (CTG⋅CAG repeat expansions and fragility, likely by unwinding problematic hairpins.

The morphology of Ganoderma lucidum mycelium in a repeated-batch fermentation for exopolysaccharide production

Directory of Open Access Journals (Sweden)

Wan Abd Al Qadr Imad Wan-Mohtar

2016-09-01

Full Text Available The morphology of Ganoderma lucidum BCCM 31549 mycelium in a repeated-batch fermentation (RBF was studied for exopolysaccharide (EPS production. RBF was optimised for time to replace and volume to replace. G. lucidum mycelium showed the ability to self-immobilise and exhibited high stability for repeated use in RBF with engulfed pellets. Furthermore, the ovoid and starburst-like pellet morphology was disposed to EPS production in the shake flask and bioreactor, respectively. Seven RBF could be carried out in 500 mL flasks, and five repeated batches were performed in a 2 L bioreactor. Under RBF conditions, autolysis of pellet core in the shake flask and shaving off of the outer hairy region in the bioreactor were observed at the later stages of RBF (R4 for the shake flask and R6 for the bioreactor. The proposed strategy showed that the morphology of G. lucidum mycelium can withstand extended fermentation cycles.

An unusual occurrence of repeated single allele variation on Y-STR locus DYS458

Directory of Open Access Journals (Sweden)

Pankaj Shrivastava

2016-09-01

Full Text Available Six brothers were accused of gagging and raping a woman. A single male Y-STR profile was obtained from vaginal smear swab and clothes of the victim, which did not match with the DNA profile of the accused brothers. As a reference point, the blood sample of their father (aged 87 years was also analyzed with the same kit. The Y-STR haplotype of all six brothers was found to be the same as that of their father except at locus DYS458. At this locus, while the eldest, second and fourth siblings share allele 18 with their father, a loss of one repeat (allele 17 instead of 18 is observed in the third son while fifth and sixth siblings have allele 19 representing a gain of one repeat. Thus, two changes viz. a gain (twice and loss of one repeat at this locus in one generation is both interesting and unusual.

Isolation of human simple repeat loci by hybridization selection.

Science.gov (United States)

Armour, J A; Neumann, R; Gobert, S; Jeffreys, A J

1994-04-01

We have isolated short tandem repeat arrays from the human genome, using a rapid method involving filter hybridization to enrich for tri- or tetranucleotide tandem repeats. About 30% of clones from the enriched library cross-hybridize with probes containing trimeric or tetrameric tandem arrays, facilitating the rapid isolation of large numbers of clones. In an initial analysis of 54 clones, 46 different tandem arrays were identified. Analysis of these tandem repeat loci by PCR showed that 24 were polymorphic in length; substantially higher levels of polymorphism were displayed by the tetrameric repeat loci isolated than by the trimeric repeats. Primary mapping of these loci by linkage analysis showed that they derive from 17 chromosomes, including the X chromosome. We anticipate the use of this strategy for the efficient isolation of tandem repeats from other sources of genomic DNA, including DNA from flow-sorted chromosomes, and from other species.

The Cauchy problem for space-time monopole equations in Sobolev spaces

Science.gov (United States)

Huh, Hyungjin; Yim, Jihyun

2018-04-01

We consider the initial value problem of space-time monopole equations in one space dimension with initial data in Sobolev space Hs. Observing null structures of the system, we prove local well-posedness in almost critical space. Unconditional uniqueness and global existence are proved for s ≥ 0. Moreover, we show that the H1 Sobolev norm grows at a rate of at most c exp(ct2).

FRB 121102: A Repeatedly Combed Neutron Star by a Nearby Low-luminosity Accreting Supermassive Black Hole

Science.gov (United States)

Zhang, Bing

2018-02-01

The origin of fast radio bursts (FRBs) remains mysterious. Recently, the only repeating FRB source, FRB 121102, was reported to possess an extremely large and variable rotation measure (RM). The inferred magnetic field strength in the burst environment is comparable to that in the vicinity of the supermassive black hole Sagittarius A* of our Galaxy. Here, we show that all of the observational properties of FRB 121102 (including the high RM and its evolution, the high linear polarization degree, an invariant polarization angle across each burst and other properties previously known) can be interpreted within the “cosmic comb” model, which invokes a neutron star with typical spin and magnetic field parameters whose magnetosphere is repeatedly and marginally combed by a variable outflow from a nearby low-luminosity accreting supermassive black hole in the host galaxy. We propose three falsifiable predictions (periodic “on/off” states, and periodic/correlated variation of RM and polarization angle) of the model and discuss other FRBs within the context of the cosmic comb model as well as the challenges encountered by other repeating FRB models in light of the new observations.

Developmental differences in stress responding after repeated underwater trauma exposures in rats.

Science.gov (United States)

Altman, Daniel E; Simmons, Laurence P; Vuong, Chau T; Taylor, Rachel M; Sousa, Jason C; Marcsisin, Sean R; Zottig, Victor E; Moore, Nicole L T

2018-05-01

Adolescence is a distinct developmental period characterized by behavioral and physiological maturation. Rapid ongoing changes during neurodevelopment in particular present potential opportunities for stress to have lasting effects on longitudinal outcomes of behavioral and neuroendocrine function. While adult stress effects on outcomes during adulthood have been characterized, little is known about the lasting effects of adolescent repeated stressor exposure on outcomes during adolescence. We have previously reported different stress responses in adolescent rats relative to adult rats, including a blunted fear response outcome in adulthood in rats stressed during adolescence. The present study characterized the ontogeny of behavioral and neuroendocrine responses to eight underwater trauma (UWT) exposures in rats over a two week poststress time period during adolescence (P34) or adulthood (P83) relative to age-matched control groups that underwent eight swimming episodes without UWT. Repeated UWT exposures starting in adolescence, but not adulthood, resulted in adverse behavioral responses on the elevated plus maze 1 day post-stress. Corticosterone responses did not differ between UWT-exposed and controls for either age group at 1 day or at 7 days poststress, although there was an effect of age on corticosterone levels. We conclude that repeated UWT stress events have a lasting, negative behavioral effect on adolescent rats that is not observed in adult rats after the two-week exposure window. These results suggest that neurophysiological mechanisms underlying recovery from a repeated stressor are immature in adolescence relative to adulthood in rats.