WorldWideScience

Sample records for reliability-based safety enhancement

  1. Development of reliability-based safety enhancement technology; development of organization concept model in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Chang Hyun; Kim, Ju Youl; Kim, Yoon Ik; Yang, Hui Chang; Lee, Yong Sik; Kim, Se Hyung [Seoul National University, Seoul (Korea)

    2002-03-01

    The influences of organizational factors on safety of nuclear power plants are mentioned in the early 1970s and noticed after being focused on in the accident report of TMI in 1979. These needs let us implement this research and the purposes of this research are to assess the organizational influences and to develop the organizational conceptual model to establish the basis of identifying the organizational factors, using this model to contribute to enhance safety and economics in nuclear power plants. Eventually research on the organizational influences is expected to have two effects, which are to improve safety through identifying potential causes of accidents and to elevate economics as a new approach to more efficient operation of nuclear power plants. In this study, recent studies were surveyed on the organizational conceptual model, the identification of organizational factors, assessment of organizational influences and evaluation methods of organizational factors and organizational influences among the overseas and domestic researches. In addition specific characteristics of domestic nuclear power plants were tried to identify through plant visit and an evaluation method of organizational influences on component maintenance and human performance were developed and presented. 71 refs., 40 figs., 18 tabs. (Author)

  2. Developing safety performance functions incorporating reliability-based risk measures.

    Science.gov (United States)

    Ibrahim, Shewkar El-Bassiouni; Sayed, Tarek

    2011-11-01

    Current geometric design guides provide deterministic standards where the safety margin of the design output is generally unknown and there is little knowledge of the safety implications of deviating from these standards. Several studies have advocated probabilistic geometric design where reliability analysis can be used to account for the uncertainty in the design parameters and to provide a risk measure of the implication of deviation from design standards. However, there is currently no link between measures of design reliability and the quantification of safety using collision frequency. The analysis presented in this paper attempts to bridge this gap by incorporating a reliability-based quantitative risk measure such as the probability of non-compliance (P(nc)) in safety performance functions (SPFs). Establishing this link will allow admitting reliability-based design into traditional benefit-cost analysis and should lead to a wider application of the reliability technique in road design. The present application is concerned with the design of horizontal curves, where the limit state function is defined in terms of the available (supply) and stopping (demand) sight distances. A comprehensive collision and geometric design database of two-lane rural highways is used to investigate the effect of the probability of non-compliance on safety. The reliability analysis was carried out using the First Order Reliability Method (FORM). Two Negative Binomial (NB) SPFs were developed to compare models with and without the reliability-based risk measures. It was found that models incorporating the P(nc) provided a better fit to the data set than the traditional (without risk) NB SPFs for total, injury and fatality (I+F) and property damage only (PDO) collisions. Copyright © 2011 Elsevier Ltd. All rights reserved.

  3. An efficient approach to reliability-based design optimization within the enhanced sequential optimization and reliability assessment framework

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Hong Zhong; Zhang, Xudong; Meng, De Biao; Wang, Zhonglai; Liu, Yu [University of Electronic Science and Technology of China, Chengdu (China)

    2013-06-15

    Reliability based design optimization (RBDO) has been widely implemented in engineering practices for high safety and reliability. It is an important challenge to improve computational efficiency. Sequential optimization and reliability assessment (SORA) has made great efforts to improve computational efficiency by decoupling a RBDO problem into sequential deterministic optimization and reliability analysis as a single-loop method. In this paper, in order to further improve computational efficiency and extend the application of the current SORA method, an enhanced SORA (ESORA) is proposed by considering constant and varying variances of random design variables while keeping the sequential framework. Some mathematical examples and an engineering case are given to illustrate the proposed method and validate the efficiency.

  4. Reliability-based Calibration of Partial Safety Factors for Wave Energy Converters

    DEFF Research Database (Denmark)

    Ambühl, Simon; Kramer, Morten Mejlhede; Sørensen, John Dalsgaard

    2015-01-01

    Wave energy converters (WECs), which harvest energy from the waves and transfer them to electricity, are a new technology, where structural standards need to be developed. An important step towards standardization is the calibration of partial safety factors. A methodology for calibration...... of partial safety factors for design of welded details for wave energy converter applications is presented in this paper using probabilistic methods. The paper presents an example with focus on the Wavestar device. SN curves and Rainflow counting are used to model fatigue without considering inspections...

  5. A Human Reliability Based Usability Evaluation Method for Safety-Critical Software

    Energy Technology Data Exchange (ETDEWEB)

    Phillippe Palanque; Regina Bernhaupt; Ronald Boring; Chris Johnson

    2006-04-01

    Recent years have seen an increasing use of sophisticated interaction techniques including in the field of safety critical interactive software [8]. The use of such techniques has been required in order to increase the bandwidth between the users and systems and thus to help them deal efficiently with increasingly complex systems. These techniques come from research and innovation done in the field of humancomputer interaction (HCI). A significant effort is currently being undertaken by the HCI community in order to apply and extend current usability evaluation techniques to these new kinds of interaction techniques. However, very little has been done to improve the reliability of software offering these kinds of interaction techniques. Even testing basic graphical user interfaces remains a challenge that has rarely been addressed in the field of software engineering [9]. However, the non reliability of interactive software can jeopardize usability evaluation by showing unexpected or undesired behaviors. The aim of this SIG is to provide a forum for both researchers and practitioners interested in testing interactive software. Our goal is to define a roadmap of activities to cross fertilize usability and reliability testing of these kinds of systems to minimize duplicate efforts in both communities.

  6. Reliability-Based Code Calibration

    DEFF Research Database (Denmark)

    Faber, M.H.; Sørensen, John Dalsgaard

    2003-01-01

    The present paper addresses fundamental concepts of reliability based code calibration. First basic principles of structural reliability theory are introduced and it is shown how the results of FORM based reliability analysis may be related to partial safety factors and characteristic values....... Thereafter the code calibration problem is presented in its principal decision theoretical form and it is discussed how acceptable levels of failure probability (or target reliabilities) may be established. Furthermore suggested values for acceptable annual failure probabilities are given for ultimate...... and serviceability limit states. Finally the paper describes the Joint Committee on Structural Safety (JCSS) recommended procedure - CodeCal - for the practical implementation of reliability based code calibration of LRFD based design codes....

  7. Optimal, Reliability-Based Code Calibration

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard

    2002-01-01

    Reliability based code calibration is considered in this paper. It is described how the results of FORM based reliability analysis may be related to the partial safety factors and characteristic values. The code calibration problem is presented in a decision theoretical form and it is discussed how...... of reliability based code calibration of LRFD based design codes....

  8. Enhancing supply vessel safety

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    A supply-vessel bridge installation consists of a navigating bridge and a control position aft, from which operators control the ship when close to rigs or platforms, and operate winches and other loading equipment. The international Convention for Safety of I Ale at Sea (SOLAS) does not regulate the layout, so design varies to a large degree, often causing an imperfect working environment. As for other types of ships, more than half the offshore service vessel accidents at sea are caused by bridge system failures. A majority can be traced back to technical design, and operational errors. The research and development project NAUT-OSV is a response to the offshore industry's safety concerns. Analysis of 24 incidents involving contact or collision between supply vessels and offshore installations owned or operated by Norwegian companies indicated that failures in the bridge system were often the cause.

  9. Reliability Based Ship Structural Design

    DEFF Research Database (Denmark)

    Dogliani, M.; Østergaard, C.; Parmentier, G.

    1996-01-01

    This paper deals with the development of different methods that allow the reliability-based design of ship structures to be transferred from the area of research to the systematic application in current design. It summarises the achievements of a three-year collaborative research project dealing...... with developments of models of load effects and of structural collapse adopted in reliability formulations which aim at calibrating partial safety factors for ship structural design. New probabilistic models of still-water load effects are developed both for tankers and for containerships. New results are presented...... of non-linear wave induced load effects and the corresponding long-term formulations. Methods to combine linear and non-linear components of wave induced load effects have been developed and checked by alternative methods.These improved models were used for the reliability assessment of the primary hull...

  10. Reliability-Based Design of Wind Turbine Components

    DEFF Research Database (Denmark)

    Toft, Henrik Stensgaard; Sørensen, John Dalsgaard

    2010-01-01

    Application of reliability-based design for wind turbines requires a definition of the probabilistic basis for the individual components of the wind turbine. In the present paper reliability-based design of structural wind turbine components is considered. A framework for the uncertainties which ...... demonstrated how partial safety factors can be derived for reliability-based design and how the partial safety factors changes dependent on the uncertainty in the test results....

  11. Contribution to a quantitative assessment model for reliability-based metrics of electronic and programmable safety-related functions; Contribution a un modele d'evaluation quantitative des performances fiabilistes de fonctions electroniques et programmables dediees a la securite

    Energy Technology Data Exchange (ETDEWEB)

    Hamidi, K

    2005-10-15

    The use of fault-tolerant EP architectures has induced growing constraints, whose influence on reliability-based performance metrics is no more negligible. To face up the growing influence of simultaneous failure, this thesis proposes, for safety-related functions, a new-trend assessment method of reliability, based on a better taking into account of time-aspect. This report introduces the concept of information and uses it to interpret the failure modes of safety-related function as the direct result of the initiation and propagation of erroneous information until the actuator-level. The main idea is to distinguish the apparition and disappearance of erroneous states, which could be defined as intrinsically dependent of HW-characteristic and maintenance policies, and their possible activation, constrained through architectural choices, leading to the failure of safety-related function. This approach is based on a low level on deterministic SED models of the architecture and use non homogeneous Markov chains to depict the time-evolution of probabilities of errors. (author)

  12. Reliability based investigation of design factors

    Energy Technology Data Exchange (ETDEWEB)

    1978-06-30

    Second-moment probabilistic techniques are used to formulate structural resistances and loads and to derive reliability-based safety, load, and strength factors for design. Existing concepts of the second-moment reliability theory have been extended to the practical case of multiple load combinations. This development consistently includes the stochastic character of loads and the unpredictable nature of their combinations. For this purpose, a new technique for the evaluation of load combinations is presented, whereby the moments of the extreme of combined loads is obtained in terms of the moments of individual loads and parameters describing their random fluctuations in time. Reliability-based safety, load, and strength factors are derived in terms of the acceptable level of risk, the coefficients of variation of the loads and resistance, uncertainties associated with errors in modeling and estimation, and a set of parameters describing the stochastic nature of loads and their combinations.

  13. Vehicle Safety Enhancement System: Sensing and Communication

    OpenAIRE

    Huihuan Qian; Yongquan Chen; Yuandong Sun; Niansheng Liu; Ning Ding; Yangsheng Xu; Guoqing Xu; Yunjian Tang; Jingyu Yan

    2013-01-01

    With the substantial increase of vehicles on road, driving safety and transportation efficiency have become increasingly concerned focus from drivers, passengers, and governments. Wireless networks constructed by vehicles and infrastructures provide abundant information to share for the sake of both enhanced safety and network efficiency. This paper presents the systematic research to enhance the vehicle safety by wireless communication, in the aspects of information acquisition through vehic...

  14. Suitable footwear for enhanced safety

    CERN Document Server

    2004-01-01

    Safety shoes are the theme of a new safety campaign. Always remember that accidents can happen - even to your feet! When entering hazardous areas such as underground halls, work sites, experiment assembly sites, workshops etc., sandals, ordinary shoes or similar light footwear should not be worn. Whatever the risks to which you may be exposed, always think safety and wear suitable footwear, i.e. safety shoes, which have non-slip soles and steel reinforcements to protect your feet from being crushed, fractured or pierced. Is it serious, Doctor? "Some traumas resulting from foot-related accidents - open fractures for instance - can be quite serious," explains CERN Works Doctor Véronique Fassnacht. "But the most common injuries are sprained ankles sustained during simple falls caused by differences in floor-levels (e.g. false floors). Fractures, bruising, surface wounds or deep wounds caused by objects falling onto the top of the foot are also quite common." ...

  15. Enhancing Safety through Generic Competencies

    Directory of Open Access Journals (Sweden)

    S. Mockel

    2014-03-01

    Full Text Available This article provides insights into proactive safety management and mitigation. An analysis of accident reports reveals categories of supervening causes of accidents which can be directly linked to the concept of generic competencies (information management, communication and coordination, problem solving, and effect control. These findings strongly suggest adding the human element as another safety-constituting pillar to the concept of ship safety next to technology and regulation. We argue that the human element has unique abilities in dealing with critical and highly dynamic situations which can contribute to the system's recovery from non-routine or critical situations. By educating seafarers in generic competencies we claim to enable the people onboard to successfully deal with critical situations.

  16. Another Approach to Enhance Airline Safety: Using Management Safety Tools

    Science.gov (United States)

    Lu, Chien-tsug; Wetmore, Michael; Przetak, Robert

    2006-01-01

    The ultimate goal of conducting an accident investigation is to prevent similar accidents from happening again and to make operations safer system-wide. Based on the findings extracted from the investigation, the "lesson learned" becomes a genuine part of the safety database making risk management available to safety analysts. The airline industry is no exception. In the US, the FAA has advocated the usage of the System Safety concept in enhancing safety since 2000. Yet, in today s usage of System Safety, the airline industry mainly focuses on risk management, which is a reactive process of the System Safety discipline. In order to extend the merit of System Safety and to prevent accidents beforehand, a specific System Safety tool needs to be applied; so a model of hazard prediction can be formed. To do so, the authors initiated this study by reviewing 189 final accident reports from the National Transportation Safety Board (NTSB) covering FAR Part 121 scheduled operations. The discovered accident causes (direct hazards) were categorized into 10 groups Flight Operations, Ground Crew, Turbulence, Maintenance, Foreign Object Damage (FOD), Flight Attendant, Air Traffic Control, Manufacturer, Passenger, and Federal Aviation Administration. These direct hazards were associated with 36 root factors prepared for an error-elimination model using Fault Tree Analysis (FTA), a leading tool for System Safety experts. An FTA block-diagram model was created, followed by a probability simulation of accidents. Five case studies and reports were provided in order to fully demonstrate the usefulness of System Safety tools in promoting airline safety.

  17. Reliability-based optimization of engineering structures

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard

    2008-01-01

    The theoretical basis for reliability-based structural optimization within the framework of Bayesian statistical decision theory is briefly described. Reliability-based cost benefit problems are formulated and exemplitied with structural optimization. The basic reliability-based optimization......-assessment and a reliability-based decision problem for offshore wind turbines....

  18. Reliability-based assessment of polyethylene pipe creep lifetime

    Energy Technology Data Exchange (ETDEWEB)

    Khelif, Rabia [LaMI-UBP and IFMA, Campus de Clermont-Fd, Les Cezeaux, BP 265, 63175 Aubiere Cedex (France); LR3MI, Departement de Genie Mecanique, Universite Badji Mokhtar, BP 12, Annaba 23000 (Algeria)], E-mail: rabia.khelif@ifma.fr; Chateauneuf, Alaa [LGC-University Blaise Pascal, Campus des Cezeaux, BP 206, 63174 Aubiere Cedex (France)], E-mail: alaa.chateauneuf@polytech.univ-bpclermont.fr; Chaoui, Kamel [LR3MI, Departement de Genie Mecanique, Universite Badji Mokhtar, BP 12, Annaba 23000 (Algeria)], E-mail: chaoui@univ-annaba.org

    2007-12-15

    Lifetime management of underground pipelines is mandatory for safe hydrocarbon transmission and distribution systems. The use of high-density polyethylene tubes subjected to internal pressure, external loading and environmental variations requires a reliability study in order to define the service limits and the optimal operating conditions. In service, the time-dependent phenomena, especially creep, take place during the pipe lifetime, leading to significant strength reduction. In this work, the reliability-based assessment of pipe lifetime models is carried out, in order to propose a probabilistic methodology for lifetime model selection and to determine the pipe safety levels as well as the most important parameters for pipeline reliability. This study is enhanced by parametric analysis on pipe configuration, gas pressure and operating temperature.

  19. Modified Fittings Enhance Industrial Safety

    Science.gov (United States)

    2012-01-01

    Kennedy Space Center is not only home to one of the largest buildings in the world - the massive Vehicle Assembly Building - it also hosts a number of one-of-a-kind facilities. The more than 30-mile-long campus has witnessed every launch from the Space Shuttle Launch Pad, as well as many homecomings at the Shuttle Landing Facility. Just as important, the Space Station Processing Facility (SSPF) has seen each element of the International Space Station (ISS) that passes through Kennedy before it goes into orbit. The SSPF is where ISS components are checked, tested, and adjusted before being packed into the Space Shuttle for transport. In an environment like the SSPF - spanning 457,000 square feet of processing areas, operational control rooms, laboratories, logistics areas, and office space - large workstands and equipment used to support the processing of ISS components need to be moved around the facility. One of the devices employed for this task is an air pallet. An air pallet moves on cushions of air instead of wheels. Compressed air inflates the cushions underneath the pallet and is then expelled through exhaust holes. This forms a thin film of air between the cushions and the floor, lifting the platform off the floor and making it easy to move the heavy workstands, equipment, and ISS components. Concerned with the safety of the connections on the pressurized air hoses used for the air pallets, engineers at Kennedy modified an existing commercial cam and groove fitting to control the air supply hose in the event of an accidental release of a pressurized hose. This modification prevented the hose from detaching and, propelled by compressed air, striking workers or equipment. "At the time, these were not available on commercial coupling halves, so NASA made a modification and then put them into use. If a worker were to accidentally try to remove a pressurized hose from the pallet, it no longer rapidly separated, and it safely relieved the pressure," says Paul

  20. Reliability Based Calibration of Fatigue Design Guidelines for Ship Structures

    DEFF Research Database (Denmark)

    Folsø, Rasmus; Otto, S.; Parmentier, G.

    2002-01-01

    A simple reliability based framework is applied to calibrate a new set of fatigue design guidelines. This new guideline considers two different approaches for the assessment of both loads, stresses and local stress raising effects, and partial safety factors must be given for any combination of t...

  1. Fiber optical sensors for enhanced battery safety

    Science.gov (United States)

    Meyer, Jan; Nedjalkov, Antonio; Doering, Alexander; Angelmahr, Martin; Schade, Wolfgang

    2015-05-01

    Over the last years, battery safety becomes more and more important due to the wide spread of high-capacity lithium ion batteries applied in e.g. consumer electronics and electrical power storages for vehicles or stationary energy storage systems. However, for these types of batteries, malfunctions could be highly dangerous and all aspects of safety issues are not sufficiently considered, yet. Therefore, the improvement of the battery safety behavior is one of the most important issues discussed in actual research projects. In this paper the application of fiber optical sensors for enhanced battery safety is presented. The temperature is one of the most critical parameters indicating a failure of the cell, but even state-to-the-art battery management systems (BMS) are not able to monitor and interpret the distributed temperature field of a total battery storage system sufficiently. Furthermore, the volume expansion of the battery cell, which could be monitored by the strain on the cells' surfaces, is one additional parameter not considered up to now. Both parameters could be simultaneous monitored by fiber optical sensor arrays, consisting of discrete fiber Bragg grating (FBG) elements. The FBG sensors are directly attached on the surface of the cell, recording the temperature as well as the strain distribution highly accurate and close-meshed. Failures and malfunction such as overcharging, gassing, and thermal runaway can be early predicted and avoided to extend the battery lifetime and enhance the operational battery safety. Moreover, battery aging effects lead to variations in the volume change behavior which can be detected additionally. Hence, a battery fully equipped with fiber optical sensor arrays in combination with an appropriate BMS enables a safe and continuous utilization of the energy storage system even under harsh conditions like rapid charging.

  2. Safety Culture Enhancement Project. Final Report. A Field Study on Approaches to Enhancement of Safety Culture

    Energy Technology Data Exchange (ETDEWEB)

    Lowe, Andrew; Hayward, Brent (Dedale Asia Pacific, Albert Park VIC 3206 (Australia))

    2006-08-15

    This report documents a study with the objective of enhancing safety culture in the Swedish nuclear power industry. A primary objective of this study was to ensure that the latest thinking on human factors principles was being recognised and applied by nuclear power operators as a means of ensuring optimal safety performance. The initial phase of the project was conducted as a pilot study, involving the senior management group at one Swedish nuclear power-producing site. The pilot study enabled the project methodology to be validated after which it was repeated at other Swedish nuclear power industry sites, providing a broad-ranging analysis of opportunities across the industry to enhance safety culture. The introduction to this report contains an overview of safety culture, explains the background to the project and sets out the project rationale and objectives. The methodology used for understanding and analysing the important safety culture issues at each nuclear power site is then described. This section begins with a summary of the processes used in the information gathering and data analysis stage. The six components of the Management Workshops conducted at each site are then described. These workshops used a series of presentations, interactive events and group exercises to: (a) provide feedback to site managers on the safety culture and safety leadership issues identified at their site, and (b) stimulate further safety thinking and provide 'take-away' information and leadership strategies that could be applied to promote safety culture improvements. Section 3, project Findings, contains the main observations and output from the project. These include: - a brief overview of aspects of the local industry operating context that impinge on safety culture; - a summary of strengths or positive attributes observed within the safety culture of the Swedish nuclear industry; - a set of identified opportunities for further improvement; - the aggregated

  3. Reliability-Based Optimization in Structural Engineering

    DEFF Research Database (Denmark)

    Enevoldsen, I.; Sørensen, John Dalsgaard

    1994-01-01

    In this paper reliability-based optimization problems in structural engineering are formulated on the basis of the classical decision theory. Several formulations are presented: Reliability-based optimal design of structural systems with component or systems reliability constraints, reliability......-based optimal inspection planning and reliability-based experiment planning. It is explained how these optimization problems can be solved by application of similar techniques. The reliability estimation is limited to first order reliability methods (FORM) for both component and systems reliability evaluation....... The solution strategies applying first order non-linear optimization algorithms are described in detail with special attention to sensitivity analysis and stability of the optimization process. Furthermore, several practical aspects are treated as: Development of the reliability-based optimization model...

  4. Enhancing Transfusion Safety: Nurse’s Role

    Directory of Open Access Journals (Sweden)

    Kyriazi Vasiliki

    2011-01-01

    Full Text Available Background: Despite strict clinical measures, there are distinct steps in transfusion process which require acute attention.The nurse is responsible for insuring that the right unit is administered to the right patient. Knowledge of risks is essential toadminister and monitor transfusions safely.Aim: This study summarizes the available data concerning transfusion adverse events and provides theoretical and technicalaspects for improving transfusion practice.Methodology: A systematic review in PubMed, MedLine and MDConsult database was conducted. The research limitsincluded English texts, referring to transfusion risks and technological means aiming at transfusion safety.Results: Blood transfusion is a medical intervention that saves lives and improves the quality of life. The regulations forensuring the availability and assuring the quality of the blood component cannot avoid transfusion errors, placing patients atrisk. Most frequent errors are attributed to practitioners involved in the clinical transfusion process. Based on reports toSerious Hazards of Transfusion (SHOT the risk of transfusion error is estimated at 1:16,500. Over the last years severalcommittees have recommended guidance for enhancing the safety of blood ordering and administration. Moreover, newtechnology like barcode on patient wristband manages to improve the performance in each step.Conclusion: Safe transfusion process depends on a series of linked processes and nurses should take specific measuresreferring to pre- and post-transfusion stage. Technological innovations could help patients in need of transfusion therapy.

  5. Reliability-Based Optimization of Wind Turbines

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Tarp-Johansen, N.J.

    2004-01-01

    Reliability-based optimization of the main tower and monopile foundation of an offshore wind turbine is considered. Different formulations are considered of the objective function including benefits and building and failure costs of the wind turbine. Also different reconstruction policies in case...

  6. Reliability Based Optimization of Fire Protection

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    It is well known that fire is one of the major risks of serious damage or total loss of several types of structures such as nuclear installations, buildings, offshore platforms/topsides etc. This paper presents a methodology and software for reliability based optimization of the layout of passive...

  7. Interactive Reliability-Based Optimal Design

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Thoft-Christensen, Palle; Siemaszko, A.

    1994-01-01

    Interactive design/optimization of large, complex structural systems is considered. The objective function is assumed to model the expected costs. The constraints are reliability-based and/or related to deterministic code requirements. Solution of this optimization problem is divided in four main...... be used in interactive optimization....

  8. Safety enhancement solutions Laguna Verde NPP

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-10-15

    After the event happened in the nuclear power plant of Fukushima (Japan) proposals are carried out to improve the safety systems in the nuclear power plant of Laguna Verde (Mexico), from the application of the recommendations of the US NRC, until the considerations for the renovation of the operation license. (Author)

  9. Enhancing Safety at Airline Operations Control Centre

    Directory of Open Access Journals (Sweden)

    Lukáš Řasa

    2015-04-01

    Full Text Available In recent years a new term of Safety Management System (SMS has been introduced into aviation legislation. This system is being adopted by airline operators. One of the groundbased actors of everyday operations is Operations Control Centre (OCC. The goal of this article has been to identify and assess risks and dangers which occur at OCC and create a template for OCC implementation into SMS.

  10. Physician attitudes towards pharmacological cognitive enhancement: safety concerns are paramount.

    Directory of Open Access Journals (Sweden)

    Opeyemi C Banjo

    2010-12-01

    Full Text Available The ethical dimensions of pharmacological cognitive enhancement have been widely discussed in academic circles and the popular media, but missing from the conversation have been the perspectives of physicians - key decision makers in the adoption of new technologies into medical practice. We queried primary care physicians in major urban centers in Canada and the United States with the aim of understanding their attitudes towards cognitive enhancement. Our primary hypothesis was that physicians would be more comfortable prescribing cognitive enhancers to older patients than to young adults. Physicians were presented with a hypothetical pharmaceutical cognitive enhancer that had been approved by the regulatory authorities for use in healthy adults, and was characterized as being safe, effective, and without significant adverse side effects. Respondents overwhelmingly reported increasing comfort with prescribing cognitive enhancers as the patient age increased from 25 to 65. When asked about their comfort with prescribing extant drugs that might be considered enhancements (sildenafil, modafinil, and methylphenidate or our hypothetical cognitive enhancer to a normal, healthy 40 year old, physicians were more comfortable prescribing sildenafil than any of the other three agents. When queried as to the reasons they answered as they did, the most prominent concerns physicians expressed were issues of safety that were not offset by the benefit afforded the individual, even in the face of explicit safety claims. Moreover, many physicians indicated that they viewed safety claims with considerable skepticism. It has become routine for safety to be raised and summarily dismissed as an issue in the debate over pharmacological cognitive enhancement; the observation that physicians were so skeptical in the face of explicit safety claims suggests that such a conclusion may be premature. Thus, physician attitudes suggest that greater weight be placed upon the

  11. Enhancing the Flight Safety Culture Through Training

    Science.gov (United States)

    Kanki, Barbara G.; Rosekind, Mark R. (Technical Monitor)

    1996-01-01

    In the 1970's, flight safety professionals became profoundly concerned about the prevalence of crew-caused accidents and incidents, and the role of human error in flight operations. As result, they initiated a change in the flight safety culture which has grown to significant proportions today. At the heart of the evolution were crew concepts such as flightdeck management, crew coordination, and cockpit resource management, concepts which seemed to target critical deficiencies. In themselves, the concepts were not new but their incorporation into training as a direct means of changing the flight safety culture was an untried, almost 'grassroots' approach. The targeted crew concepts and skills were not an integral part of the typical training program; the methods, curriculum, media, and even course content itself, would have to be developed and implemented from the bottom up. A familiar truism in the pilot culture is that you should 'Train the way you fly; Fly the way you train'. In short, training was expected to provide the pilot with practical operational skills that were consistent with the performance standards they were required to maintain and the operational demands they met on a daily basis. In short, one could not simply command crews to use good CRM; one would have to research and define these skills operationally as well as develop and implement a consistent and effective training program. Furthermore, one would need active support and collaboration among the research, industry and government communities in order to ensure acceptance and continued commitment. Additional information is contained in the original extended abstract.

  12. Enhancing surgical safety using digital multimedia technology.

    Science.gov (United States)

    Dixon, Jennifer L; Mukhopadhyay, Dhriti; Hunt, Justin; Jupiter, Daniel; Smythe, William R; Papaconstantinou, Harry T

    2016-06-01

    The purpose of this study was to examine whether incorporating digital and video multimedia components improved surgical time-out performance of a surgical safety checklist. A prospective pilot study was designed for implementation of a multimedia time-out, including a patient video. Perceptions of the staff participants were surveyed before and after intervention (Likert scale: 1, strongly disagree to 5, strongly agree). Employee satisfaction was high for both time-out procedures. However, employees appreciated improved clarity of patient identification (P digital method. About 87% of the respondents preferred the digital version to the standard time-out (75% anesthesia, 89% surgeons, 93% nursing). Although the duration of time-outs increased (49 and 79 seconds for standard and digital time-outs, respectively, P > .001), there was significant improvement in performance of key safety elements. The multimedia time-out allows improved participation by the surgical team and is preferred to a standard time-out process. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. Two RFID-based solutions to enhance inpatient medication safety.

    Science.gov (United States)

    Chien, Hung-Yu; Yang, Chia-Chuan; Wu, Tzong-Chen; Lee, Chin-Feng

    2011-06-01

    Owing to the low cost and convenience of identifying an object without physical contact, Radio Frequency Identification (RFID) systems provide innovative, promising and efficient applications in many domains. An RFID grouping protocol is a protocol that allows an off-line verifier to collect and verify the evidence of two or more tags simultaneously present. Recently, Huang and Ku (J. Med. Syst, 2009) proposed an efficient grouping protocol to enhance medication safety for inpatients based on low-cost tags. However, the Huang-Ku scheme is not secure; an attacker can easily make up fake grouping records to cheat the verifier. This weakness would seriously endanger the safety of inpatient medication safety. This paper will show the weaknesses, and then propose two RFID-based solutions to enhance medication safety for two different scenarios. The proposed schemes are practical, secure and efficient for medication applications.

  14. Reliability Based Optimization of Structural Systems

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard

    1987-01-01

    The optimization problem to design structural systems such that the reliability is satisfactory during the whole lifetime of the structure is considered in this paper. Some of the quantities modelling the loads and the strength of the structure are modelled as random variables. The reliability....... For these optimization problems it is described how a sensitivity analysis can be performed. Next, new optimization procedures to solve the optimization problems are presented. Two of these procedures solve the system reliability based optimization problem sequentially using quasi-analytical derivatives. Finally...... is estimated using first. order reliability methods ( FORM ). The design problem is formulated as the optimization problem to minimize a given cost function such that the reliability of the single elements satisfies given requirements or such that the systems reliability satisfies a given requirement...

  15. Generic Reliability-Based Inspection Planning for Fatigue Sensitive Details

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Straub, Daniel; Faber, Michael Havbro

    2005-01-01

    expected costs for design, inspections, repairs and failures are minimized. The method is based on the assumption of “no-finds” of cracks during inspections. Each fatigue sensitive detail is categorized according to their type of details (SN curves), FDF values, RSR values, inspection, repair and failure......The generic approach for planning of in-service NDT inspections is extended to cover the case where the fatigue load is modified during the design lifetime of the structure. Generic reliability-based inspection planning has been developed as a practical approach to perform inspection planning...... of fatigue sensitive details in fixed offshore steel jacket platforms and FPSO ship structures. Inspection and maintenance activities are planned such that code based requirements to the safety of personnel and environment for the considered structure are fulfilled and at the same time such that the overall...

  16. Enhancing Road Safety Behaviour Using a Psychological and Spiritual Approaches

    Directory of Open Access Journals (Sweden)

    Ghous Mohd Tarmizi

    2017-01-01

    Full Text Available Main causes of accident is due to driver itself that is influenced by their bad attitude while driving. Human attitude is closely related to the human psychology. Apart from that, spiritual aspect also influence human attitude. Hence, this study carried out to improve driver safety using a new approach through psychology and spiritual factors. Objectives of this study are to identify then analyze factors of psychological and spiritual that contribute towards safety driving. A self-administered questionnaire were distributed among 256 respondents from various type of background. An analysis descriptive statistics show demographic and experience of respondents. Chi-square analysis showed only education level and traffic summon are significant to safety driving. Furthermore, correlation analysis shows psychological factors has strong linear relationship on attitude of drivers towards safety driving while spiritual factor, the perception of the spiritual and practices, both have a strong relationship to safety driving. Regression analysis demonstrates boths psychological and spiritual factors have strong evidence and significant relationship with safety driving. Thus, it can be identified that spiritual psychological factors encourage drivers to drive more safely and reduce road accidents. Therefore, this study propose useful guidelines to related agencies in order to enhance safety among drivers to be able drive safely on the road.

  17. RFID authentication protocol to enhance patient medication safety.

    Science.gov (United States)

    Kaul, Sonam Devgan; Awasthi, Amit K

    2013-12-01

    Medication errors can cause substantial harm to patients. Automated patient medication system with RFID technology is purposely used to reduce the medication error, to improve the patient safety, to provide personalized patient medication and identification and also to provide counterfeit protection to the patients. In order to enhance medication safety for patients we propose a new dynamic ID based lightweight RFID authentication protocol. Due to low storage capacity and limited computational and communicational capacity of tags, only pseudo random number generator function, one way hash function and bitwise Xor operation are used in our authentication protocol. The proposed protocol is practical, secure and efficient for health care domain.

  18. A safety culture training program enhanced the perceptions of patient safety culture of nurse managers.

    Science.gov (United States)

    Xie, Jian-Fei; Ding, Si-Qing; Zhong, Zhu-Qing; Zeng, Sai-Nan; Qin, Chun-Xiang; Yi, Qi-Feng; Gong, Li-Na; Zhou, Jian-da

    2017-11-01

    Positive perceptions of patient safety culture are associated with lower rates of adverse events, but they have not been widely established in many health care organizations. The purpose of this study is to examine the impacts of a safety culture training program (SCTP) on enhancing the perceptions of patient safety in nurse managers. This was a quasi-experimental design. 83 nurse managers were recruited from five randomly selected 2nd level hospitals. Sixty-seven nurse managers received training under the educational SCTP. The Hospital Survey on Patient Safety Culture (HSPSC) and Chinese Safety Attitudes Questionnaire (C-SAQ) were administered just before and six months after the educational program. The data of hospital-acquired pressure ulcers, patient falls, and unplanned extubations were collected. The total positive scores of HSPSC were significantly improved and four dimensions of C-SAQ significantly increased six months after SCTP. The rate of patient falls and rate of hospital-acquired pressure ulcers decreased significantly six months post SCTP. In conclusion, nurse manager participation in a SCTP can enhance the perceptions of patient safety and reduce the rates of adverse events. More rigorous trials with larger numbers of participants and a control group are needed to strengthen the conclusions. Copyright © 2017. Published by Elsevier Ltd.

  19. Optimal Reliability-Based Code Calibration

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Kroon, I. B.; Faber, Michael Havbro

    1994-01-01

    Calibration of partial safety factors is considered in general, including classes of structures where no code exists beforehand. The partial safety factors are determined such that the difference between the reliability for the different structures in the class considered and a target reliability...... level is minimized. Code calibration on a decision theoretical basis is also considered and it is shown how target reliability indices can be calibrated. Results from code calibration for rubble mound breakwater designs are shown....

  20. Reliability Based Code calibration. The use of the JCSS Probabilistic Model Code

    NARCIS (Netherlands)

    Vrouwenvelder, A.C.W.M.

    2002-01-01

    A reliability based code calibration procedure is a two step procedure. In the first step target reliabilities are set on the basis of experience or optimisation and in the second step corresponding partial factors and other safety elements (e.g. PSI-values as in Eurocode 1) are derived. This paper

  1. Criticality safety enhancements for SCALE 6.2 and beyond

    Energy Technology Data Exchange (ETDEWEB)

    Rearden, Bradley T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bekar, Kursat B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Celik, Cihangir [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Clarno, Kevin T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dunn, Michael E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hart, Shane W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ibrahim, Ahmad M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Johnson, Seth R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Langley, Brandon R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lefebvre, Jordan P. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lefebvre, Robert A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Marshall, William J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Mertyurek, Ugur [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Mueller, Don [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Peplow, Douglas E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Perfetti, Christopher M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Petrie Jr, Lester M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Thompson, Adam B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wiarda, Dorothea [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wieselquist, William A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Williams, Mark L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-01

    SCALE is a widely used suite of tools for nuclear systems modeling and simulation that provides comprehensive, verified and validated, user-friendly capabilities for criticality safety, reactor physics, radiation shielding, and sensitivity and uncertainty analysis. Since 1980, regulators, industry, and research institutions around the world have relied on SCALE for nuclear safety analysis and design. SCALE 6.2 provides several new capabilities and significant improvements in many existing features for criticality safety analysis. Enhancements are realized for nuclear data; multigroup resonance self-shielding; continuous-energy Monte Carlo analysis for sensitivity/uncertainty analysis, radiation shielding, and depletion; and graphical user interfaces. An overview of these capabilities is provided in this paper, and additional details are provided in several companion papers.

  2. An Approach for the Reliability Based Design Optimization of Laminated Composite Plates

    OpenAIRE

    Lopez, Rafael Holdorf; Lemosse, Didier; Cursi, Eduardo Souza de; Rojas, Jhojan Enrique; El-Hami, Abdelkhalak

    2011-01-01

    Abstract This paper aims at optimizing laminated composite plates taking into account uncertainties in the structural dimensions. As laminated composites require a global optimization tool, the Particle Swarm (PSO) Optimization method was employed. A new reliability based design optimization (RBDO) methodology based on safety factors is presented and coupled with the PSO. Such safety factors are derived from the Karush-Kuhn-Tucker (KKT) optimality conditions of the reliability inde...

  3. Enhancement of safety at nuclear facilities in Pakistan

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, S.A.; Hayat, T.; Azhar, W. [Directorate of Safety, Pakistan Atomic Energy Commission, P.O. Box 3416, Islamabad (Pakistan)

    2006-07-01

    Pakistan is benefiting from nuclear technology mostly in health and energy sectors as well as agriculture and industry and has an impeccable safety record. At the national level uses of nuclear technology started in 1955 resulting in the operation of Karachi Radioisotope Center, Karachi, in December 1960. Pakistan Nuclear Safety Committee (PNSC) was formulated in 1964 with subsequent promulgation of Pakistan Atomic Energy Commission (PAEC) Ordinance in 1965 to cope with the anticipated introduction of a research reactor, namely PARR-I, and a nuclear power plant, namely KANUPP. Since then Pakistan's nuclear program has expanded to include numerous nuclear facilities of varied nature. This program has definite economic and social impacts by producing electricity, treating and diagnosing cancer patients, and introducing better crop varieties. Appropriate radiation protection includes a number of measures including database of sealed radiation sources at PAEC operated nuclear facilities, see Table l, updated during periodic physical verification of these sources, strict adherence to the BSS-115, IAEA recommended enforcement of zoning at research reactors and NPPs, etc. Pakistan is party to several international conventions and treaties, such as Convention of Nuclear Safety and Early Notification, to improve and enhance safety at its nuclear facilities. In addition Pakistan generally and PAEC particularly believes in a blend of prudent regulations and good/best practices. This is described in this paper. (Author)

  4. Enhanced Maritime Safety through Diagnosis and Fault Tolerant Control

    DEFF Research Database (Denmark)

    Blanke, Mogens

    2001-01-01

    -tolerant control is a methodology to help prevent that faults develop into failure. The means include on-line fault diagnosis, automatic condition assessment and calculation of remedial action to avoid hazards. This paper gives an overview of methods to obtain fault-tolerance: fault diagnosis; analysis......Faults in steering, navigation instruments or propulsion machinery are serious on a marine vessel since the consequence could be loss of maneuvering ability, and imply risk of damage to vessel personnel or environment. Early diagnosis and accomodation of faults could enhance safety. Fault...

  5. A comprehensive RFID solution to enhance inpatient medication safety.

    Science.gov (United States)

    Peris-Lopez, Pedro; Orfila, Agustin; Mitrokotsa, Aikaterini; van der Lubbe, Jan C A

    2011-01-01

    Errors involving medication administration can be costly, both in financial and in human terms. Indeed, there is much potential for errors due to the complexity of the medication administration process. Nurses are often singled out as the only responsible of these errors because they are in charge of drug administration. Nevertheless, the interventions of every actor involved in the process and the system design itself contribute to errors (Wakefield et al. (1998). Proper inpatient medication safety systems can help to reduce such errors in hospitals. In this paper, we review in depth two recent proposals (Chien et al. (2010); Huang and Ku (2009)) that pursue the aforementioned objective. Unfortunately, they fail in their attempt mainly due to their security faults but interesting ideas can be drawn from both. These security faults refer to impersonation and replay attacks that could produce the generation of a forged proof stating that certain medication was administered to an inpatient when it was not. We propose a leading-edge solution to enhance inpatient medication safety based on RFID technology that overcomes these weaknesses. Our solution, named Inpatient Safety RFID system (IS-RFID), takes into account the Information Technology (IT) infrastructure of a hospital and covers every phase of the drug administration process. From a practical perspective, our system can be easily integrated within hospital IT infrastructures, has a moderate cost, is very ease to use and deals with security aspects as a key point. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  6. Integrating Metatheory to Enhance Qualitative Interviewing: A Safety Campaign Exemplar

    Directory of Open Access Journals (Sweden)

    Marifran Mattson PhD

    2014-02-01

    Full Text Available This article examines the ways in which integrating a metatheory to guide qualitative interviews supports health theory and the research methodology of interviewing. This study applied Harm Reduction Theory (HRT as a metatheory to the Reconceptualized Health Belief Model (RHBM in targeting motorcyclists to practice safety behaviors. After integrating the metatheory with a health behavior theory to develop research questions and frame the interview guide, we recruited and interviewed 37 at-risk motorcyclists. The process of interviewing participants and the results of the study support the integration of harm reduction metatheory to enhance interview methodology as a way to effectively engage participants by building rapport, encouraging participants to apply theory, and empowering them to be open and honest in their responses. This research process highlights ways in which incorporating a metatheory to guide theory diverges from the more traditional, theory-driven approach to interviewing.

  7. Using Total Lightning Observations to Enhance Lightning Safety

    Science.gov (United States)

    Stano, Geoffrey T.

    2012-01-01

    Lightning is often the underrated threat faced by the public when it comes to dangerous weather phenomena. Typically, larger scale events such as floods, hurricanes, and tornadoes receive the vast majority of attention by both the general population and the media. This comes from the fact that these phenomena are large, longer lasting, can impact a large swath of society at one time, and are dangerous events. The threat of lightning is far more isolated on a case by case basis, although millions of cloud-to-ground lightning strikes hit this United States each year. While attention is given to larger meteorological events, lightning is the second leading cause of weather related deaths in the United States. This information raises the question of what steps can be taken to improve lightning safety. Already, the meteorological community s understanding of lightning has increased over the last 20 years. Lightning safety is now better addressed with the National Weather Service s access to the National Lightning Detection Network data and enhanced wording in their severe weather warnings. Also, local groups and organizations are working to improve public awareness of lightning safety with easy phrases to remember, such as "When Thunder Roars, Go Indoors." The impacts can be seen in the greater array of contingency plans, from airports to sports stadiums, addressing the threat of lightning. Improvements can still be made and newer technologies may offer new tools as we look towards the future. One of these tools is a network of sensors called a lightning mapping array (LMA). Several of these networks exist across the United States. NASA s Short-term Prediction Research and Transition Center (SPoRT), part of the Marshall Spaceflight Center, has access to three of these networks from Huntsville, Alabama, the Kennedy Space Center, and Washington D.C. The SPoRT program s mission is to help transition unique products and observations into the operational forecast environment

  8. Food safety security: a new concept for enhancing food safety measures.

    Science.gov (United States)

    Iyengar, Venkatesh; Elmadfa, Ibrahim

    2012-06-01

    The food safety security (FSS) concept is perceived as an early warning system for minimizing food safety (FS) breaches, and it functions in conjunction with existing FS measures. Essentially, the function of FS and FSS measures can be visualized in two parts: (i) the FS preventive measures as actions taken at the stem level, and (ii) the FSS interventions as actions taken at the root level, to enhance the impact of the implemented safety steps. In practice, along with FS, FSS also draws its support from (i) legislative directives and regulatory measures for enforcing verifiable, timely, and effective compliance; (ii) measurement systems in place for sustained quality assurance; and (iii) shared responsibility to ensure cohesion among all the stakeholders namely, policy makers, regulators, food producers, processors and distributors, and consumers. However, the functional framework of FSS differs from that of FS by way of: (i) retooling the vulnerable segments of the preventive features of existing FS measures; (ii) fine-tuning response systems to efficiently preempt the FS breaches; (iii) building a long-term nutrient and toxicant surveillance network based on validated measurement systems functioning in real time; (iv) focusing on crisp, clear, and correct communication that resonates among all the stakeholders; and (v) developing inter-disciplinary human resources to meet ever-increasing FS challenges. Important determinants of FSS include: (i) strengthening international dialogue for refining regulatory reforms and addressing emerging risks; (ii) developing innovative and strategic action points for intervention {in addition to Hazard Analysis and Critical Control Points (HACCP) procedures]; and (iii) introducing additional science-based tools such as metrology-based measurement systems.

  9. Enhancing passenger safety and security in Ghana: Appraising ...

    African Journals Online (AJOL)

    There are increasing calls for regular monitoring and evaluation of safety and security strategies of public transport (PT) operators, especially in developing countries where PT safety and security concerns abound. In respect of this, this study examined the passenger safety and security interventions of PT operators in ...

  10. Roadway and roadside design for enhancing mobilitity and safety.

    NARCIS (Netherlands)

    Schoon, C.C.

    1998-01-01

    Safety barriers are often used on motorways. Accident figures, however, show that a safety barrier is involved in approximately 20% of all fatal accidents. This paper considers safety barriers within the context of safe designs for shoulders on motorways. This research is related to the European

  11. Reliability-based design of wind turbine blades

    DEFF Research Database (Denmark)

    Toft, Henrik Stensgaard; Sørensen, John Dalsgaard

    2011-01-01

    Reliability-based design of wind turbine blades requires identification of the important failure modes/limit states along with stochastic models for the uncertainties and methods for estimating the reliability. In the present paper it is described how reliability-based design can be applied to wind...... turbine blades. For wind turbine blades, tests with the basic composite materials and a few full-scale blades are normally performed during the design process. By adopting a reliability-based design approach, information from these tests can be taken into account in a rational way during the design...... process. In the present paper, a probabilistic framework for design of wind turbine blades are presented and it is demonstrated how information from tests can be taken into account using the Maximum-Likelihood method and Bayesian statistics. In a numerical example, the reliability is estimated for a wind...

  12. Interactive Reliability-Based Optimization of Structural Systems

    DEFF Research Database (Denmark)

    Pedersen, Claus

    In order to introduce the basic concepts within the field of reliability-based structural optimization problems, this chapter is devoted to a brief outline of the basic theories. Therefore, this chapter is of a more formal nature and used as a basis for the remaining parts of the thesis. In section...... 2.2 a general non-linear optimization problem and corresponding terminology are presented whereupon optimality conditions and the standard form of an iterative optimization algorithm are outlined. Subsequently, the special properties and characteristics concerning structural optimization problems...... the reliability-based structural optimization (RBSO) problem is formulated and described....

  13. Strengthening leadership as a catalyst for enhanced patient safety culture

    DEFF Research Database (Denmark)

    Kristensen, Solvejg; Christensen, Karl Bang; Jaquet, Annette

    2016-01-01

    in the Safety Attitudes Questionnaire. To broaden knowledge and strengthen leadership skills, a multicomponent programme consisting of academic input, exercises, reflections and discussions, networking, and action learning was implemented among the clinical area level leaders. RESULTS: In total, 358 and 325...... in a Danish psychiatric department before and after a leadership intervention. METHODS: A repeated cross-sectional experimental study by design was applied. In 2 surveys, healthcare staff were asked about their perceptions of the patient safety culture using the 7 patient safety culture dimensions...... rated job satisfaction lower than the staff staying on (pleadership can act as a significant catalyst for patient safety culture improvement. Further studies using...

  14. Reliability based Robustness of Timber Structures through NDT Data Updating

    DEFF Research Database (Denmark)

    Sousa, Hélder S.; Sørensen, John Dalsgaard; Kirkegaard, Poul Henning

    2011-01-01

    This work presents a framework for reliability-based assessment of timber structures / members using data gathered from non-destructive test results. These results are used for modeling an update of the mechanical characteristics of timber, using Bayesian methods. Results gathered from ultrasound...

  15. Planning of operation & maintenance using risk and reliability based methods

    DEFF Research Database (Denmark)

    Florian, Mihai; Sørensen, John Dalsgaard

    2015-01-01

    Operation and maintenance (OM) of offshore wind turbines contributes with a substantial part of the total levelized cost of energy (LCOE). The objective of this paper is to present an application of risk- and reliability-based methods for planning of OM. The theoretical basis is presented...

  16. Decomposition Techniques and Effective Algorithms in Reliability-Based Optimization

    DEFF Research Database (Denmark)

    Enevoldsen, I.; Sørensen, John Dalsgaard

    1995-01-01

    The common problem of an extensive number of limit state function calculations in the various formulations and applications of reliability-based optimization is treated. It is suggested to use a formulation based on decomposition techniques so the nested two-level optimization problem can be solv...

  17. Optimal Reliability-Based Planning of Experiments for POD Curves

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Faber, M. H.; Kroon, I. B.

    Optimal planning of the crack detection test is considered. The test are used to update the information on the reliability of the inspection techniques modelled by probability of detection (P.O.D.) curves. It is shown how cost-optimal and reliability based test plans can be obtained using First...

  18. Contractors’ Attitude towards Enhancing Safety Performance: Case Study on Construction Firms in Penang

    Directory of Open Access Journals (Sweden)

    Ulang N. Md

    2014-01-01

    Full Text Available A qualitative study was conducted to investigate the contractors’ attitude towards enhancing the safety performance in construction site. Despite the fact that there are many safety initiatives established by the government, the rates of accidents are still in a critically high condition. Thus the purpose of this research is to study the contractors’ attitude towards enhancing the implementation of safety management system in construction site in order to increase the safety awareness of construction practitioners in construction site and improve the safety condition of construction sites. This study is conducted through oral interviews with the construction practitioners, and visual inspection of construction sites. The attitudes of contractors are evaluated from 3 aspects: Contractors’ efforts in implement and enforce the safety rules, Contractors efforts in overcoming the rate of accidents, and Reasons given by the contractors for not implement safety law.

  19. Enhancing vaccine safety capacity globally: A lifecycle perspective

    NARCIS (Netherlands)

    R.T. Chen (Robert T.); T.T. Shimabukuro (Tom T.); D.B. Martin (David); P. Zuber (Patrick); D.M. Weibel (Daniel); M.C.J.M. Sturkenboom (Miriam)

    2015-01-01

    textabstractMajor vaccine safety controversies have arisen in several countries beginning in the last decades of 20th century. Such periodic vaccine safety controversies are unlikely to go away in the near future as more national immunization programs mature with near elimination of target

  20. Enhancing vaccine safety capacity globally: a lifecycle perspective

    Science.gov (United States)

    Chen, Robert T.; Shimabukuro, Tom T.; Martin, David B.; Zuber, Patrick L.F.; Weibel, Daniel M.; Sturkenboom, Miriam

    2015-01-01

    Major vaccine safety controversies have arisen in several countries beginning in the last decades of 20th Century. Such periodic vaccine safety controversies are unlikely to go away in the near future as more national immunization programs mature with near elimination of target vaccine-preventable diseases that result in relative greater prominence of adverse events following immunizations, both true reactions and temporally coincidental events. There are several ways in which vaccine safety capacity can be improved in the future to potentially mitigate the impact of future vaccine safety controversies. This paper aims to take a “lifecycle” approach, examining some potential pre- and post-licensure opportunities to improve vaccine safety, in both developed (specifically U.S. and Europe) and low- and middle- income countries. PMID:26433922

  1. Ensuring Food Security Through Enhancing Microbiological Food Safety

    Science.gov (United States)

    Mikš-Krajnik, Marta; Yuk, Hyun-Gyun; Kumar, Amit; Yang, Yishan; Zheng, Qianwang; Kim, Min-Jeong; Ghate, Vinayak; Yuan, Wenqian; Pang, Xinyi

    2015-10-01

    Food safety and food security are interrelated concepts with a profound impact on the quality of human life. Food security describes the overall availability of food at different levels from global to individual household. While, food safety focuses on handling, preparation and storage of foods in order to prevent foodborne illnesses. This review focuses on innovative thermal and non-thermal technologies in the area of food processing as the means to ensure food security through improving food safety with emphasis on the reduction and control of microbiological risks. The antimicrobial efficiency and mechanism of new technologies to extend the shelf life of food product were also discussed.

  2. Regional aviation safety organisations: enhancing air transport safety through regional cooperation

    OpenAIRE

    Ratajczyk, Mikołaj Andrzej

    2014-01-01

    Aviation safety is of global concern. Yet 43% of countries worldwide lack the expertise and administrative capacity to ensure effective safety oversight of the aviation activities for which they are responsible under international law. With air traffic predicted to double in the next 15 years and increasing pressure on public administrations budgets, countries are increasingly pooling their resources to improve aviation safety. One of the ways States can achieve regulatory efficiencies and in...

  3. Reliability-Based Maintenance and Inspection Planning for Wind Turbines

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard

    2004-01-01

    , local buckling of main tower, and failure of the foundation. This paper considers reliability-based optimal inspection and maintenance planning of wind turbines. Different formulations are considered of the objective function including benefits, building costs of the wind turbine, inspection...... and maintenance costs, and failure costs. Different reconstruction policies in case of failure are considered, including systematic reconstruction in case of failure, no reconstruction and failure of the control system. The concept of generic inspection and maintenance planning coupled with information from...

  4. Regional aviation safety organisations : enhancing air transport safety through regional cooperation

    NARCIS (Netherlands)

    Ratajczyk, Mikołaj Andrzej

    2014-01-01

    Aviation safety is of global concern. Yet 43% of countries worldwide lack the expertise and administrative capacity to ensure effective safety oversight of the aviation activities for which they are responsible under international law. With air traffic predicted to double in the next 15 years and

  5. 78 FR 53790 - Public Forum-Safety Culture: Enhancing Transportation Safety

    Science.gov (United States)

    2013-08-30

    ... Culture; Organizational Leadership Perspectives on Safety Culture; Safety Culture Management and Oversight.... Opening Statement by Acting Chairman Hersman. 2. Introduction of the Technical Panels and Panelists. 3.... Opening Statement by Acting Chairman Hersman. 2. Introduction of the Technical Panels and Panelists. 3...

  6. Enhanced FAA-hybrid III numerical dummy model in Madymo for aircraft occupant safety assessment

    NARCIS (Netherlands)

    Boucher, H.; Waagmeester, C.D.

    2003-01-01

    To improve survivability and to minimize the risk of injury to occupants in helicopter crash events, a complete Cabin Safety System concept including safety features and an enhanced FAA-Hybrid III dummy were developed within the HeliSafe project. A numerical tool was also created and validated to

  7. ENHANCING FOOD SAFETY AND STABILITY THROUGH IRRADIATION: A REVIEW

    Directory of Open Access Journals (Sweden)

    Manzoor Ahmad Shah

    2014-04-01

    Full Text Available Food irradiation is one of the non thermal food processing methods. It is the process of exposing food materials to the controlled amounts of ionizing radiations such as gamma rays, X-rays and accelerated electrons, to improve microbiological safety and stability. Irradiation disrupts the biological processes that lead to decay of food quality. It is an effective tool to reduce food-borne pathogens, spoilage microorganisms and parasites; to extend shelf-life and for insect disinfection. The safety and consumption of irradiated foods have been extensively studied at national levels and in international cooperations and have concluded that foods irradiated under appropriate technologies are both safe and nutritionally adequate. Specific applications of food irradiation have been approved by national legislations of more than 55 countries worldwide. This review aims to discuss the applications of irradiation in food processing with the emphasis on food safety and stability.

  8. Mobilizing local safety nets for enhanced adaptive capacity to ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-04-22

    Apr 22, 2016 ... This brief explores how the erosion of Zunde raMambo — a traditional community safety net mechanism — over time has increased the vulnerability of communities through weakened community cohesion and collective action in addressing local problems. A renewal of Zunde raMambo could help to ...

  9. Mobilizing local safety nets for enhanced adaptive capacity to ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    22 avr. 2016 ... In Zimbabwe, the increased frequency of drought, flash floods, and unpredictable rainfall has added to recurrent food deficits for poor households who depend on rainfed farming on nutrient poor soils. This brief explores how the erosion of Zunde raMambo — a traditional community safety net mechanism ...

  10. Safety Enhancement Technologies for Airport Ramp Area Operations Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA has been involved in developing advanced automation systems for improving the efficiency of air-traffic operations, reducing controller workload and enhancing...

  11. Non-technical skills training to enhance patient safety.

    Science.gov (United States)

    Gordon, Morris

    2013-06-01

      Patient safety is an increasingly recognised issue in health care. Systems-based and organisational methods of quality improvement, as well as education focusing on key clinical areas, are common, but there are few reports of educational interventions that focus on non-technical skills to address human factor sources of error. A flexible model for non-technical skills training for health care professionals has been designed based on the best available evidence, and with sound theoretical foundations.   Educational sessions to improve non-technical skills in health care have been described before. The descriptions lack the details to allow educators to replicate and innovate further.   A non-technical skills training course that can be delivered as either a half- or full-day intervention has been designed and delivered to a number of mixed groups of undergraduate medical students and doctors in postgraduate training. Participant satisfaction has been high and patient safety attitudes have improved post-intervention.   This non-technical skills educational intervention has been built on a sound evidence base, and is described so as to facilitate replication and dissemination. With the key themes laid out, clinical educators will be able to build interventions focused on numerous clinical issues that pay attention to human factor contributors to safety. © 2013 John Wiley & Sons Ltd.

  12. Reliability-Based Structural Optimization of Wave Energy Converters

    DEFF Research Database (Denmark)

    Ambühl, Simon; Kramer, Morten; Sørensen, John Dalsgaard

    2014-01-01

    More and more wave energy converter (WEC) concepts are reaching prototype level. Once the prototype level is reached, the next step in order to further decrease the levelized cost of energy (LCOE) is optimizing the overall system with a focus on structural and maintenance (inspection) costs......, as well as on the harvested power from the waves. The target of a fully-developed WEC technology is not maximizing its power output, but minimizing the resulting LCOE. This paper presents a methodology to optimize the structural design of WECs based on a reliability-based optimization problem...

  13. Optimal Reliability-Based Planning of Experiments for POD Curves

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Faber, Michael Havbro; Kroon, I. B.

    Optimal planning of the crack detection test is considered. The test are used to update the information on the reliability of the inspection techniques modelled by probability of detection (P.O.D.) curves. It is shown how cost-optimal and reliability based test plans can be obtained using First O...... Order Reliability Methods in combination with life-cycle cost-optimal inspection and maintenance planning. The methodology is based on preposterior analyses from Bayesian decision theory. An illustrative example is shown....

  14. Reliability-Based Robustness Analysis for a Croatian Sports Hall

    DEFF Research Database (Denmark)

    Čizmar, Dean; Kirkegaard, Poul Henning; Sørensen, John Dalsgaard

    2011-01-01

    This paper presents a probabilistic approach for structural robustness assessment for a timber structure built a few years ago. The robustness analysis is based on a structural reliability based framework for robustness and a simplified mechanical system modelling of a timber truss system....... A complex timber structure with a large number of failure modes is modelled with only a few dominant failure modes. First, a component based robustness analysis is performed based on the reliability indices of the remaining elements after the removal of selected critical elements. The robustness...

  15. 75 FR 73014 - Notice of Public Meeting: Updating the Flight Instructor Renewal Process To Enhance Safety of Flight

    Science.gov (United States)

    2010-11-29

    ... Renewal Process To Enhance Safety of Flight AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... to improve the Certificated Flight Instructor (CFI) biennial renewal process to enhance the safety of... [email protected] . SUPPLEMENTARY INFORMATION: Background The FAA has been reviewing safety of flight...

  16. Enhancing safety of laparoscopic vascular control for neonatal sacrococcygeal teratoma.

    Science.gov (United States)

    Solari, Valeria; Jawaid, Wajid; Jesudason, Edwin C

    2011-05-01

    Life-threatening bleeding is a hazard of major tumor excision in children. However, fatalities from inadvertent arterial ligation should not be overlooked. Sacrococcygeal teratoma is the commonest neonatal tumor. Laparotomy to ligate the median sacral artery has been used to preempt potentially fatal resectional bleeding. Use of laparoscopy to achieve the same is an evolving technique, with only 7 neonatal cases described. As such, the Idea, Development, Exploration, Assessment, Long-term study (IDEAL) guidelines on surgical innovation recommend case reports addressing proof of concept, technical factors and safety tips. Fortunately, mistaken arterial division is so far unreported during laparoscopic median sacral artery ligation. However, as uptake widens, anatomical distortion by tumor and surgeon disorientation at endosurgery are risk factors for even such inconceivable complications. We report a successful case of laparoscopic vascular control for neonatal sacrococcygeal teratoma and demonstrate an observation that serves as a useful safety check for this procedure (as well as the open alternative). Copyright © 2011 Elsevier Inc. All rights reserved.

  17. 78 FR 3311 - Safety Enhancements, Certification of Airports

    Science.gov (United States)

    2013-01-16

    ... more rigorous control procedures and requiring enhanced visual aids. Additionally, the ability to... an air carrier operating aircraft designed for more than nine passenger seats, as determined by the... manuals contain a SMGCS plan for airports approved for operations below 1,200 feet runway visual range. A...

  18. Segmentation Scheme for Safety Enhancement of Engineered Safety Features Component Control System

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sangseok; Sohn, Kwangyoung [Korea Reliability Technology and System, Daejeon (Korea, Republic of); Lee, Junku; Park, Geunok [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-05-15

    Common Caused Failure (CCF) or undetectable failure would adversely impact safety functions of ESF-CCS in the existing nuclear power plants. We propose the segmentation scheme to solve these problems. Main function assignment to segments in the proposed segmentation scheme is based on functional dependency and critical function success path by using the dependency depth matrix. The segment has functional independence and physical isolation. The segmentation structure is that prohibit failure propagation to others from undetectable failures. Therefore, the segmentation system structure has robustness to undetectable failures. The segmentation system structure has functional diversity. The specific function in the segment defected by CCF, the specific function could be maintained by diverse control function that assigned to other segments. Device level control signals and system level control signals are separated and also control signal and status signals are separated due to signal transmission paths are allocated independently based on signal type. In this kind of design, single device failure or failures on signal path in the channel couldn't result in the loss of all segmented functions simultaneously. Thus the proposed segmentation function is the design scheme that improves availability of safety functions. In conventional ESF-CCS, the single controller generates the signal to control the multiple safety functions, and the reliability is achieved by multiplication within the channel. This design has a drawback causing the loss of multiple functions due to the CCF (Common Cause Failure) and single failure Heterogeneous controller guarantees the diversity ensuring the execution of safety functions against the CCF and single failure, but requiring a lot of resources like manpower and cost. The segmentation technology based on the compartmentalization and functional diversification decreases the CCF and single failure nonetheless the identical types of

  19. Tumor lysis syndrome: prevention and detection to enhance patient safety.

    Science.gov (United States)

    Maloney, Kristen; Denno, Mary

    2011-12-01

    Patient safety is at the forefront of health care and nursing practice. Oncology nurses strive to provide safe oncologic care in their management of cancer, treatments, and side effects. Oncologic emergencies such as tumor lysis syndrome (TLS), however, are serious complications of cancer and cancer treatment. TLS often is seen in hematologic malignancies, such as lymphomas and leukemias, that frequently occur in older adults. As the population in the United States continues to age, nurses must be prepared to manage oncologic emergencies in older adults. Understanding the risk factors and preventive strategies for TLS provides oncology nurses with a foundation for managing a serious treatment complication. Patients and their caregivers need to understand the importance of preventive measures for TLS; therefore, patient education must be a critical part of the oncology nurse's plan of care.

  20. Enhancing the usability of safety software for microcomputers.

    Science.gov (United States)

    Greenberg, L

    1984-07-01

    With the proliferation of microcomputers, increasing effort is being made to write programs dealing with occupational safety and health. So as to assure the widespread use of this material, it is important that it be prepared in a manner easy to use. Ignoring this consideration may cause the potential users to be repelled by it from the start, or that its use will be difficult and error-prone. This article dwells on some of the points that need to be borne in mind when writing such software to make it easy and pleasant to use. Additionally, a project, carried out by the author, is described, which makes use of a free-form program access approach, as opposed to a purely menu-driven one. Two potential extensions of this approach are then described.

  1. Reliability-Based Multidisciplinary Design Optimization under Correlated Uncertainties

    Directory of Open Access Journals (Sweden)

    Huanwei Xu

    2017-01-01

    Full Text Available Complex mechanical system is usually composed of several subsystems, which are often coupled with each other. Reliability-based multidisciplinary design optimization (RBMDO is an efficient method to design such complex system under uncertainties. However, the present RBMDO methods ignored the correlations between uncertainties. In this paper, through combining the ellipsoidal set theory and first-order reliability method (FORM for multidisciplinary design optimization (MDO, characteristics of correlated uncertainties are investigated. Furthermore, to improve computational efficiency, the sequential optimization and reliability assessment (SORA strategy is utilized to obtain the optimization result. Both a mathematical example and a case study of an engineering system are provided to illustrate the feasibility and validity of the proposed method.

  2. Reliability-Based Shape Optimization using Stochastic Finite Element Methods

    DEFF Research Database (Denmark)

    Enevoldsen, Ib; Sørensen, John Dalsgaard; Sigurdsson, G.

    1991-01-01

    (7). In this paper a reliability-based shape optimization problem is formulated with the total expected cost as objective function and some requirements for the reliability measures (element or systems reliability measures) as constraints, see section 2. As design variables sizing variables......Application of first-order reliability methods FORM (see Madsen, Krenk & Lind [8)) in structural design problems has attracted growing interest in recent years, see e.g. Frangopol [4), Murotsu, Kishi, Okada, Yonezawa & Taguchi [9) and Sørensen [14). In probabilistically based optimal design...... stochastic fields (e.g. loads and material parameters such as Young's modulus and the Poisson ratio). In this case stochastic finite element techniques combined with FORM analysis can be used to obtain measures of the reliability of the structural systems, see Der Kiureghian & Ke (6) and Liu & Der Kiureghian...

  3. Fatigue reliability based optimal design of planar compliant micropositioning stages

    Science.gov (United States)

    Wang, Qiliang; Zhang, Xianmin

    2015-10-01

    Conventional compliant micropositioning stages are usually developed based on static strength and deterministic methods, which may lead to either unsafe or excessive designs. This paper presents a fatigue reliability analysis and optimal design of a three-degree-of-freedom (3 DOF) flexure-based micropositioning stage. Kinematic, modal, static, and fatigue stress modelling of the stage were conducted using the finite element method. The maximum equivalent fatigue stress in the hinges was derived using sequential quadratic programming. The fatigue strength of the hinges was obtained by considering various influencing factors. On this basis, the fatigue reliability of the hinges was analysed using the stress-strength interference method. Fatigue-reliability-based optimal design of the stage was then conducted using the genetic algorithm and MATLAB. To make fatigue life testing easier, a 1 DOF stage was then optimized and manufactured. Experimental results demonstrate the validity of the approach.

  4. Fast unambiguous stereo matching using reliability-based dynamic programming.

    Science.gov (United States)

    Gong, Minglun; Yang, Yee-Hong

    2005-06-01

    An efficient unambiguous stereo matching technique is presented in this paper. Our main contribution is to introduce a new reliability measure to dynamic programming approaches in general. For stereo vision application, the reliability of a proposed match on a scanline is defined as the cost difference between the globally best disparity assignment that includes the match and the globally best assignment that does not include the match. A reliability-based dynamic programming algorithm is derived accordingly, which can selectively assign disparities to pixels when the corresponding reliabilities exceed a given threshold. The experimental results show that the new approach can produce dense (> 70 percent of the unoccluded pixels) and reliable (error rate < 0.5 percent) matches efficiently (< 0.2 sec on a 2GHz P4) for the four Middlebury stereo data sets.

  5. Optimal reliability-based design of offshore wind turbine parks

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard

    2006-01-01

    A basic formulation for optimal reliability-based design of wind turbine parks is presented. Based on this model a probabilistic model and representative limit state equations for structural failure of wind turbine towers are formulated. The probability of failure is determined taking into account...... that wind turbines are parked for wind speeds larger than 25 m/s resulting in reduced wind loads. Basic relationships are described for the mean wind velocity and turbulence intensity in wind turbine parks with emphasis on the spatial correlation. The expected total failure costs for the wind turbine park...... the single wind turbines. An illustrative example is presented which indicates the importance of modelling the spatial dependency both of turbulence within a wind turbine park and of the yield strength....

  6. Engineering Solutions to Enhance Traffic Safety Performance on Two-Lane Highways

    Directory of Open Access Journals (Sweden)

    Lina Wu

    2015-01-01

    Full Text Available Improving two-lane highway traffic safety conditions is of practical importance to the traffic system, which has attracted significant research attention within the last decade. Many cost-effective and proactive solutions such as low-cost treatments and roadway safety monitoring programs have been developed to enhance traffic safety performance under prevailing conditions. This study presents research perspectives achieved from the Highway Safety Enhancement Project (HSEP that assessed safety performance on two-lane highways in Beijing, China. Potential causal factors are identified based on proposed evaluation criteria, and primary countermeasures are developed against inferior driving conditions such as sharp curves, heavy gradients, continuous downgrades, poor sight distance, and poor clear zones. Six cost-effective engineering solutions were specifically implemented to improve two-lane highway safety conditions, including (1 traffic sign replacement, (2 repainting pavement markings, (3 roadside barrier installation, (4 intersection channelization, (5 drainage optimization, and (6 sight distance improvement. The effectiveness of these solutions was examined and evaluated based on Empirical Bayes (EB models. The results indicate that the proposed engineering solutions effectively improved traffic safety performance by significantly reducing crash occurrence risks and crash severities.

  7. Enhancing patient safety in the operating theatre: from the perspective of experienced operating theatre nurses.

    Science.gov (United States)

    Ingvarsdottir, Eydis; Halldorsdottir, Sigridur

    2017-09-22

    Surgical care is an extensive component of modern health care, but patient safety issues and complications of surgery have been identified as a major cause of death and disability. The aim of this study was to identify, from the perspective of experienced operating theatre nurses (OTNs), how patient safety in the operating theatre (OT) can be enhanced. In this phenomenological study, 14 individual interviews were conducted with a purposive sample of 11 participants: ten women and one man. Work experience as an OTN spanned 10-40 years. Mean experience was 16 years. The enhancement of patient safety in the OT from the perspective of the experienced OTNs is a constant endeavour of managing risks and preventing patient harm it involves respecting the vulnerability of the patient in the OT by being attentive to the patient at each moment, making contact with the patient and recognising how the patient loses all control by being anaesthetised or sedated and is, therefore totally dependent on OT staff. It also involves the OTN navigating the patient as safely as possible through the perioperative process by careful preparation, the use of protocols and checklists and taking measures to prevent complications and harm. Moreover, it involves contributing to a culture of safety by improving work conditions in the OT. Certain competencies of the OTN are essential for the enhancement of patient safety in the OT. These involve both nontechnical and technical competencies. Constantly managing risk and preventing the OT patient from harm is essential according to the experienced OTNs, who are in a key position to identify threats to patient safety and should be empowered to enhance patient safety as a constant endeavour. © 2017 Nordic College of Caring Science.

  8. Mentorship for newly appointed physicians: a strategy for enhancing patient safety?

    Science.gov (United States)

    Harrison, Reema; McClean, Serwaa; Lawton, Rebecca; Wright, John; Kay, Clive

    2014-09-01

    Mentorship is an increasingly popular innovation from business and industry that is being applied in health-care contexts. This paper explores the concept of mentorship for newly appointed physicians in their first substantive senior post, and specifically its utilization to enhance patient safety. Semi-structured face to face and telephone interviews with Medical Directors (n = 5), Deputy Medical Directors (n = 4), and Clinical Directors (n = 6) from 9 acute NHS Trusts in the Yorkshire and Humber region in the north of England. A focused thematic analysis was used. A number of beneficial outcomes were associated with mentorship for newly appointed physicians including greater personal and professional support, organizational commitment, and general well-being. Providing newly appointed senior physicians with support through mentorship was considered to enhance the safety of patient care. Mentorship may prevent or reduce active failures, be used to identify threats in the local working environment, and in the longer term, address latent threats to safety within the organization by encouraging a healthier safety culture. Offering mentorship to all newly appointed physicians in their first substantive post in health care may be a useful strategy to support the development of their clinical, professional, and personal skills in this transitional period that may also enhance the safety of patient care.

  9. Outline of the Fukushima Daiichi Accident. Lessons Learned and Safety Enhancements

    Directory of Open Access Journals (Sweden)

    Hirano Masashi

    2017-01-01

    This paper briefly presents the outline of the Fukushima Daiichi accident and summarizes the major lessons learned having been drawn and safety enhancements having been done in Japan for the purpose of giving inputs to the discussions to be taken place in the Special Invited Session “Fukushima, 5 years after”.

  10. An efficient approach for reliability-based topology optimization

    Science.gov (United States)

    Kanakasabai, Pugazhendhi; Dhingra, Anoop K.

    2016-01-01

    This article presents an efficient approach for reliability-based topology optimization (RBTO) in which the computational effort involved in solving the RBTO problem is equivalent to that of solving a deterministic topology optimization (DTO) problem. The methodology presented is built upon the bidirectional evolutionary structural optimization (BESO) method used for solving the deterministic optimization problem. The proposed method is suitable for linear elastic problems with independent and normally distributed loads, subjected to deflection and reliability constraints. The linear relationship between the deflection and stiffness matrices along with the principle of superposition are exploited to handle reliability constraints to develop an efficient algorithm for solving RBTO problems. Four example problems with various random variables and single or multiple applied loads are presented to demonstrate the applicability of the proposed approach in solving RBTO problems. The major contribution of this article comes from the improved efficiency of the proposed algorithm when measured in terms of the computational effort involved in the finite element analysis runs required to compute the optimum solution. For the examples presented with a single applied load, it is shown that the CPU time required in computing the optimum solution for the RBTO problem is 15-30% less than the time required to solve the DTO problems. The improved computational efficiency allows for incorporation of reliability considerations in topology optimization without an increase in the computational time needed to solve the DTO problem.

  11. Reliability-Based Structural Optimization of Wave Energy Converters

    Directory of Open Access Journals (Sweden)

    Simon Ambühl

    2014-12-01

    Full Text Available More and more wave energy converter (WEC concepts are reaching prototypelevel. Once the prototype level is reached, the next step in order to further decrease thelevelized cost of energy (LCOE is optimizing the overall system with a focus on structuraland maintenance (inspection costs, as well as on the harvested power from the waves.The target of a fully-developed WEC technology is not maximizing its power output,but minimizing the resulting LCOE. This paper presents a methodology to optimize thestructural design of WECs based on a reliability-based optimization problem and the intentto maximize the investor’s benefits by maximizing the difference between income (e.g., fromselling electricity and the expected expenses (e.g., structural building costs or failure costs.Furthermore, different development levels, like prototype or commercial devices, may havedifferent main objectives and will be located at different locations, as well as receive varioussubsidies. These points should be accounted for when performing structural optimizationsof WECs. An illustrative example on the gravity-based foundation of the Wavestar deviceis performed showing how structural design can be optimized taking target reliability levelsand different structural failure modes due to extreme loads into account.

  12. Enhancing Communication to Improve Patient Safety and to Increase Patient Satisfaction.

    Science.gov (United States)

    Burgener, Audrey M

    With the continuous rise of sentinel and adverse events due to ineffective communication, it is time for health care organizations to start implementing a focus on enhancing effective communication in which will, in turn, improve patient safety and experience, boosting the bottom line. This article identifies and discusses different communication protocols that can be used to enhance the consistency of more efficient and effective communication within a health care organization to overall improve patient care and patient satisfaction. The rising importance of patient satisfaction and Hospital Consumer Assessment of Healthcare Providers and Systems scores required by the Centers for Medicare and Medicaid Services are causing a shift in how hospitals evaluate and manage their health care organizations today. Following the situation-background-assessment-recommendation and acknowledge-introduce-duration-explain-thank protocols, as well as proper and effective training and educational programs, enhances more effective communication in health care organizations which improves patient safety and increases patient satisfaction.

  13. An Approach to Enhancement of the Safety Culture of Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yong Hee [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    The culture of an organization is very complex to study and evaluate, but it is possible to examine the specific norms that figure out the culture for the safety of a system. This paper describes an initiation plan to study the safety culture issue in Korean NPPs. Recently there happened successively events that turned out to be socially prominent in Korea. Many issues on the safety culture aspect of NPPs have been raised including the types of errors such as violations, an intended concealment of safety-related information, counterfeit items, forgery process in procurement, and so on. Those were investigated in detail for the root causes of these issues as human and organizational errors and for the countermeasures to prevent those events. They are integrated into a correspondent long-term plan including the establishment of a fundamental infrastructure of safety culture management for operating NPPs in Korea. A monitoring system with analysis functions utilizing system dynamics simulation and data mining is proposed to be incorporated into a safety culture management system. Additionally, a set of training and support programs are to be developed for the enhancement of some selected competence of the operating personnel in Korean NPPs. The safe operation of NPPs requires the typical safety culture characteristics of the high reliability organization (HRO). The culture of an organization is very complex to study and evaluate, but it is possible to examine the specific norms that figure out the culture for the safety of a system. This paper describes an integrated systems approach as an initiating plan to study the safety culture issue in Korean NPPs.

  14. Reliability-based design optimization using convex approximations and sequential optimization and reliability assessment method

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Tae Min; Lee, Byung Chai [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2010-01-15

    In this study, an effective method for reliability-based design optimization (RBDO) is proposed enhancing sequential optimization and reliability assessment (SORA) method by convex approximations. In SORA, reliability estimation and deterministic optimization are performed sequentially. The sensitivity and function value of probabilistic constraint at the most probable point (MPP) are obtained in the reliability analysis loop. In this study, the convex approximations for probabilistic constraint are constructed by utilizing the sensitivity and function value of the probabilistic constraint at the MPP. Hence, the proposed method requires much less function evaluations of probabilistic constraints in the deterministic optimization than the original SORA method. The efficiency and accuracy of the proposed method were verified through numerical examples

  15. Reliability - Based Design of Reinforced Concrete Two-Way Solid ...

    African Journals Online (AJOL)

    In this work, a FORTRAN-based computer program was developed to aid the design of reinforced concrete slabs to Eurocode 2 (EC 2)[1]design requirements at constant reliability levels using First Order Reliability Method (FORM).The design variables for the design of the slab were considered random with safety indices ...

  16. Sentinels of safety: service dogs ensure safety and enhance freedom and well-being for families with autistic children.

    Science.gov (United States)

    Burrows, Kristen E; Adams, Cindy L; Spiers, Jude

    2008-12-01

    Children with autism might display unpredictable and volatile behavior that places them in considerable physical danger and creates stress for the family. Families of autistic children often have limited freedom and experience difficulty with everyday activities. In this qualitative ethology study, we examined the effect of integrating service dogs into ten families with an autistic child. Data included participant observation, video recordings of family-parent-dog interaction, and semistructured interviews with the parents. The themes were (a) the dog as a sentinel of safety, (b) gaining freedom through enhanced safety, facilitating public outings and family activities, and (c) improving social recognition and status, in which the presence of the dog promoted awareness of autism and affected social interaction. The triadic relationship between parent, autistic child, and service dog constantly evolves. This research provides valuable information for parents interested in having a service dog for their autistic child, and has implications for long-term human-animal companionship for children with special needs and their caregivers.

  17. The Ex Hoc Infrastructure - Enhancing Traffic Safety through LIfe WArning Systems

    DEFF Research Database (Denmark)

    Hansen, Klaus Marius; Kristensen, Lars Michael; Eskildsen, Toke

    2004-01-01

    New pervasive computing technologies for sensing and communication open up novel possibilities for enhancing traffic safety. We are currently designing and implementing the Ex Hoc infrastructure framework for communication among mobile and stationary units including vehicles. The infrastructure...... will connect sensing devices on vehicles with sensing devices on other vehicles and with stationary communication units placed alongside roads. The current application of Ex Hoc is to enable the collection and dissemination of information on road condition through LIfe Warning Systems (LIWAS) units....

  18. Physical hurdles to enhance watercress' quality and safety: Effects on chemical and bioactive parameters

    OpenAIRE

    Pinela, José; Barreira, João C.M.; Fernandes, Ângela; Cabo Verde, Sandra; Antonio, Amilcar L.; Carvalho, Ana Maria; Oliveira, M.B.P.P.; Ferreira, Isabel C.F.R.

    2015-01-01

    The hurdle concept provides a framework for combining a number of milder preservation factors (hurdles) in order to achieve an enhanced level of product safety and stability. For fresh vegetables such as watercress (Nasturtium officinale R. Br.), characterised by a reduced shelf-life, some of these hurdle have focused on the use of modified atmosphere packaging (MAP) combined with other physical or physicochemical factors (Alexandre et al., 2011; Silveira et al., 2014). Thus, i...

  19. Development of seismic technology and reliability based on vibration tests

    Energy Technology Data Exchange (ETDEWEB)

    Sasaki, Youichi [Nuclear Power Engineering Corp., Tokyo (Japan)

    1997-03-01

    This paper deals with some of the vibration tests and investigations on the seismic safety of nuclear power plants (NPPs) in Japan. To ensure the reliability of the seismic safety of nuclear power plants, nuclear power plants in Japan have been designed according to the Technical Guidelines for Aseismic Design of Nuclear Power Plants. This guideline has been developed based on technical date base and findings which were obtained from many vibration tests and investigations. Besides the tests for the guideline, proving tests on seismic reliability of operating nuclear power plants equipment and systems have been carried out. In this paper some vibration tests and their evaluation results are presented. They have crucially contributed to develop the guideline. (J.P.N.)

  20. Short-term initiatives for enhancing cyber-safety within South African schools

    Directory of Open Access Journals (Sweden)

    Elmarie Kritzinger

    2016-07-01

    Full Text Available The rate of technological development across the globe is dramatic. The decreasing cost and increasing availability of ICT devices means that its users are no longer exclusively industry or government employees – they are now also home users. Home users integrate ICT in their daily lives for education, socialising and information gathering. However, using ICT is associated with risks and threats, such as identity theft and phishing scams. Most home users of ICT do not have the necessary information technology and Internet skills to protect themselves and their information. School learners, in particular, are not sufficiently educated on how to use technological devices safely, especially in developing countries such as South Africa. The national school curriculum in South Africa currently does not make provision for cyber-safety education, and the availability of supporting material and training for ICT teachers in South Africa is limited, resulting in a lack of knowledge and skills regarding cyber-safety. The research in hand focuses on the situation concerning cyber-safety awareness in schools and has adopted a short-term approach towards cyber-safety among teachers and school learners in South Africa until a formal long-term national approach has been implemented. This study takes a quantitative approach to investigating the current options of teachers to enhance cyber-safety among learners in their schools. The research proposes that short-term initiatives (i.e. posters can increase learners’ awareness of cyber-safety until formal cyber-safety awareness methods have been introduced.

  1. SAFETY

    CERN Multimedia

    Niels Dupont

    2013-01-01

    CERN Safety rules and Radiation Protection at CMS The CERN Safety rules are defined by the Occupational Health & Safety and Environmental Protection Unit (HSE Unit), CERN’s institutional authority and central Safety organ attached to the Director General. In particular the Radiation Protection group (DGS-RP1) ensures that personnel on the CERN sites and the public are protected from potentially harmful effects of ionising radiation linked to CERN activities. The RP Group fulfils its mandate in collaboration with the CERN departments owning or operating sources of ionising radiation and having the responsibility for Radiation Safety of these sources. The specific responsibilities concerning "Radiation Safety" and "Radiation Protection" are delegated as follows: Radiation Safety is the responsibility of every CERN Department owning radiation sources or using radiation sources put at its disposition. These Departments are in charge of implementing the requi...

  2. Reliability-Based Performance Assessment of Damaged Ships

    Science.gov (United States)

    2006-10-01

    Castanheta, M. (1971). "Structural Safety 2nd Edition", Laboratorio Nacional de Engenharia Civil, Lisbon, Portugal. Borresen, R. & Tellsgard, F. (1980...Collette, M. (2005b). "Front End: Documentation and User’s Guide Version 0. 1", University of Newcastle. COMREL & STRUREL Manual , RCP GmbH, Federal...deflection behaviour of stiffened panels. User’s Manual ", Pusan National Univ., Korea. Paik J.K., Kim D.H., Bong H.S., Kim M.S., Han S.K. (1992

  3. An RFID solution for enhancing inpatient medication safety with real-time verifiable grouping-proof.

    Science.gov (United States)

    Chen, Yu-Yi; Tsai, Meng-Lin

    2014-01-01

    The occurrence of a medication error can threaten patient safety. The medication administration process is complex and cumbersome, and nursing staffs are prone to error when they are tired. Proper Information Technology (IT) can assist the nurse in correct medication administration. We review a recent proposal regarding a leading-edge solution to enhance inpatient medication safety by using RFID technology. The proof mechanism is the kernel concept in their design and worth studying to develop a well-designed grouping-proof scheme. Other RFID grouping-proof protocols could be similarly applied in administering physician orders. We improve on the weaknesses of previous works and develop a reading-order independent RFID grouping-proof scheme in this paper. In our scheme, tags are queried and verified under the direct control of the authorized reader without connecting to the back-end database server. Immediate verification in our design makes this application more portable and efficient and critical security issues have been analyzed by the threat model. Our scheme is suitable for the safe drug administration scenario and the drug package scenario in a hospital environment to enhance inpatient medication safety. It automatically checks for correct drug unit-dose and appropriate inpatient treatments. Copyright © 2013. Published by Elsevier Ireland Ltd.

  4. Calibration Methods for Reliability-Based Design Codes

    DEFF Research Database (Denmark)

    Gayton, N.; Mohamed, A.; Sørensen, John Dalsgaard

    2004-01-01

    efficient methods. In our approach, the accuracy is balanced with time efficiency by the mean of iterative scheme using approximate methods. The presented ideas are clarified by four numerical examples of parabolic performance function, column buckling, stability of submarine shells and structural elements.......The calibration methods are applied to define the optimal code format according to some target safety levels. The calibration procedure can be seen as a specific optimization process where the control variables are the partial factors of the code. Different methods are available in the literature......, but the choice of an appropriate method is not usually an easy task. Each method can be shown to have a better performance for a particular kind of problems. The scope of this paper is to underline the advantages and disadvantages of the classical methods, to define their domain of validity and to propose new...

  5. Enhancing Patient Safety Event Reporting. A Systematic Review of System Design Features.

    Science.gov (United States)

    Gong, Yang; Kang, Hong; Wu, Xinshuo; Hua, Lei

    2017-08-30

    Electronic patient safety event reporting (e-reporting) is an effective mechanism to learn from errors and enhance patient safety. Unfortunately, the value of e-reporting system (a software or web server based platform) in patient safety research is greatly overshadowed by low quality reporting. This paper aims at revealing the current status of system features, detecting potential gaps in system design, and accordingly proposing suggestions for future design and implementation of the system. Three literature databases were searched for publications that contain informative descriptions of e-reporting systems. In addition, both online publicly accessible reporting forms and systems were investigated. 48 systems were identified and reviewed. 11 system design features and their frequencies of occurrence (Top 5: widgets (41), anonymity or confidentiality (29), hierarchy (20), validator (17), review notification (15)) were identified and summarized into a system hierarchical model. The model indicated the current e-reporting systems are at an immature stage in their development, and discussed their future development direction toward efficient and effective systems to improve patient safety.

  6. Reliability-based assessment of flow assurance of hot waxy crude pipelines

    Energy Technology Data Exchange (ETDEWEB)

    Jinjun, Zhang; Wenke, Zhang; Jianlin, Ding; Bo, Yu [China University of Petroleum - Beijing (CUPB), Beijing (China)

    2009-07-01

    Waxy crude is characterized by its high pour point. Pipeline blockage may occur after prolonged shutdown of a pipeline due to crude oil gelation. Another flow assurance problem is the instable operation at a flow rate below the lowest allowable operation flow rate which is dependent on heat transfer of the pipeline and the viscosity vs. temperature relation of the crude pumped. Besides, for pipelines with thick wax deposition layer, massive depletion of wax deposit in some cases such as pipeline restart at high expelling pressure may also result in blockage of the pipeline, and the pig may be jammed during pigging as a result of thick wax deposition. Conventionally, assessment of these risks has been made by using the deterministic approach. However, many related physical quantities are subject to uncertainty and contribute to reliability of flow assurance. Therefore, the probabilistic approach is suggested and a framework of reliability based assessment of flow assurance of waxy crude pipelines is proposed in this paper. Discussions are also made on the limit state functions and target safety level. In the future study, development of an efficient and robust stochastic-numerical method is crucial. (author)

  7. 47{sup th} Annual meeting on nuclear technology (AMNT 2016). Key topic / Enhanced safety and operation excellence

    Energy Technology Data Exchange (ETDEWEB)

    Traichel, Anke [NUKEM Technologies Engineering Services GmbH, Alzenau (Germany). Dept. of Safety Engineering and Assessment / Proposals Engineering

    2017-04-15

    Summary report on the Key Topic ''Enhanced Safety and Operation Excellence'' Technical Session ''Safety, IT, Hazards and PSA'' of the 47th Annual Meeting on Nuclear Technology (AMNT 2016) held in Hamburg, 10 to 12 May 2016.

  8. A Secure ECC-based RFID Mutual Authentication Protocol to Enhance Patient Medication Safety.

    Science.gov (United States)

    Jin, Chunhua; Xu, Chunxiang; Zhang, Xiaojun; Li, Fagen

    2016-01-01

    Patient medication safety is an important issue in patient medication systems. In order to prevent medication errors, integrating Radio Frequency Identification (RFID) technology into automated patient medication systems is required in hospitals. Based on RFID technology, such systems can provide medical evidence for patients' prescriptions and medicine doses, etc. Due to the mutual authentication between the medication server and the tag, RFID authentication scheme is the best choice for automated patient medication systems. In this paper, we present a RFID mutual authentication scheme based on elliptic curve cryptography (ECC) to enhance patient medication safety. Our scheme can achieve security requirements and overcome various attacks existing in other schemes. In addition, our scheme has better performance in terms of computational cost and communication overhead. Therefore, the proposed scheme is well suitable for patient medication systems.

  9. Safety of Pulsed High Intensity Focused Ultrasound for Enhanced Drug and Gene Delivery

    Science.gov (United States)

    Kam, Anthony W.; Wang, Honghui; Farahani, Keyvan; Thomasson, David; O'Neill, Brian; Angstadt, Mary; Jesson, Johnny; Li, King C. P.

    2007-05-01

    For a limited range of exposure parameters, pulsed high intensity focused ultrasound (HIFU) has been shown to increase the delivery of certain systemically administered macromolecular diagnostic and therapeutic agents in mice. The mechanism for the enhanced delivery has not been demonstrated definitively and, in principle, can include thermal, cavitational, and non-cavitation mechanical effects. The sonicated tissue has no damage on histology. As a step towards clinical translation, the safety of this technique needs to be assessed in a clinically relevant manner. In this study, the safety of pulsed HIFU is evaluated with near real-time phase shift magnetic resonance (MR) thermometry and anatomic MR imaging using rabbits as subjects. MR guidance enables pulsed HIFU enhanced delivery to be implemented safely from a thermal standpoint. Although the effects of pulsed HIFU are not seen on anatomic MR images, they may be detected on MR sequences sensitive to permeability, diffusion, and elasticity. Such work that may optimize pulsed HIFU enhanced delivery is in progress.

  10. Reliability-Based Calibration of Partial Safety Factors for Wind Turbine Blades

    DEFF Research Database (Denmark)

    Toft, Henrik Stensgaard; Branner, Kim; Sørensen, John Dalsgaard

    2011-01-01

    The reliability of a wind turbine blade can be estimated using a response surface technique, the First Order Reliability Method (FORM) and Monte Carlo simulation. The response surface is here estimated based on nonlinear finite element analysis by which nonlinear failure modes due to e.g. bucklin...... of the unidirectional laminas. For this failure mode the reliability is estimated along the centreline of the main spar cap. The results show significant variations in the reliability along the blade length....

  11. Reliability-based evaluation of bridge components for consistent safety margins.

    Science.gov (United States)

    2010-10-01

    The Load and Resistant Factor Design (LRFD) approach is based on the concept of structural reliability. The approach is more : rational than the former design approaches such as Load Factor Design or Allowable Stress Design. The LRFD Specification fo...

  12. Reliability-Based Calibration of Partial Safety Factors for Wind Turbine Blades

    DEFF Research Database (Denmark)

    Toft, Henrik Stensgaard; Branner, Kim; Sørensen, John Dalsgaard

    2011-01-01

    The reliability of a wind turbine blade can be estimated using a response surface technique, the First Order Reliability Method (FORM) and Monte Carlo simulation. The response surface is here estimated based on nonlinear finite element analysis by which nonlinear failure modes due to e.g. buckling...... can be taken into account. Stochastic models for the material properties and the load-effect are formulated in order to take physical, model and statistical uncertainties into account. The blade fails due to buckling of the main spar cap which results in high stresses in the transverse direction...

  13. Reliability-based condition assessment of steel containment and liners

    Energy Technology Data Exchange (ETDEWEB)

    Ellingwood, B.; Bhattacharya, B.; Zheng, R. [Johns Hopkins Univ., Baltimore, MD (United States). Dept. of Civil Engineering

    1996-11-01

    Steel containments and liners in nuclear power plants may be exposed to aggressive environments that may cause their strength and stiffness to decrease during the plant service life. Among the factors recognized as having the potential to cause structural deterioration are uniform, pitting or crevice corrosion; fatigue, including crack initiation and propagation to fracture; elevated temperature; and irradiation. The evaluation of steel containments and liners for continued service must provide assurance that they are able to withstand future extreme loads during the service period with a level of reliability that is sufficient for public safety. Rational methodologies to provide such assurances can be developed using modern structural reliability analysis principles that take uncertainties in loading, strength, and degradation resulting from environmental factors into account. The research described in this report is in support of the Steel Containments and Liners Program being conducted for the US Nuclear Regulatory Commission by the Oak Ridge National Laboratory. The research demonstrates the feasibility of using reliability analysis as a tool for performing condition assessments and service life predictions of steel containments and liners. Mathematical models that describe time-dependent changes in steel due to aggressive environmental factors are identified, and statistical data supporting the use of these models in time-dependent reliability analysis are summarized. The analysis of steel containment fragility is described, and simple illustrations of the impact on reliability of structural degradation are provided. The role of nondestructive evaluation in time-dependent reliability analysis, both in terms of defect detection and sizing, is examined. A Markov model provides a tool for accounting for time-dependent changes in damage condition of a structural component or system. 151 refs.

  14. RELIABILITY BASED DESIGN OF FIXED FOUNDATION WIND TURBINES

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, R.

    2013-10-14

    Recent analysis of offshore wind turbine foundations using both applicable API and IEC standards show that the total load demand from wind and waves is greatest in wave driven storms. Further, analysis of overturning moment loads (OTM) reveal that impact forces exerted by breaking waves are the largest contributor to OTM in big storms at wind speeds above the operating range of 25 m/s. Currently, no codes or standards for offshore wind power generators have been adopted by the Bureau of Ocean Energy Management Regulation and Enforcement (BOEMRE) for use on the Outer Continental Shelf (OCS). Current design methods based on allowable stress design (ASD) incorporate the uncertainty in the variation of loads transferred to the foundation and geotechnical capacity of the soil and rock to support the loads is incorporated into a factor of safety. Sources of uncertainty include spatial and temporal variation of engineering properties, reliability of property measurements applicability and sufficiency of sampling and testing methods, modeling errors, and variability of estimated load predictions. In ASD these sources of variability are generally given qualitative rather than quantitative consideration. The IEC 61400‐3 design standard for offshore wind turbines is based on ASD methods. Load and resistance factor design (LRFD) methods are being increasingly used in the design of structures. Uncertainties such as those listed above can be included quantitatively into the LRFD process. In LRFD load factors and resistance factors are statistically based. This type of analysis recognizes that there is always some probability of failure and enables the probability of failure to be quantified. This paper presents an integrated approach consisting of field observations and numerical simulation to establish the distribution of loads from breaking waves to support the LRFD of fixed offshore foundations.

  15. Integrating Visibility, Parking Restriction, and Driver's Field View for Enhancing Pedestrian Crossing Safety

    Directory of Open Access Journals (Sweden)

    Chiu Liu, PhD, PE, PTOE

    2013-12-01

    Full Text Available Pedestrians at a marked but unsignalized pedestrian crossing (Ped-Xing must be made visible to drivers in the approaching traffic at a sufficient distance away from the crossing, and this distance is needed for stopping a vehicle before the leading Ped-Xing edge to avoid a potential traffic collision. In this paper, an exact analytic framework is established to integrate driver's field view, driver's perception-reaction, lighting condition, and parking restriction at a Ped-Xing for enhancing traffic operational safety. The size of the no parking zone by the Ped-Xing is determined exactly using equations derived from this framework. Additionally, this study sheds the light on mid-block Ped-Xing installation, which should be discouraged if parking is permitted alongside a street. Furthermore, additional visibility improvement measures at the unsignalized Ped-Xings may be needed for enhancing safe traffic operations at the crossings.

  16. Safety Enhancements for PHWRs Based on Macroscopic Losses of the Fukushima Accident

    Directory of Open Access Journals (Sweden)

    Sang Ho Kim

    2015-01-01

    Full Text Available The role of nuclear energy is to supply electric power on a stable basis to meet increasing demands, reduce carbon dioxide emissions, and maintain stable electric power costs while ensuring safety. The Fukushima accident taught us many lessons for creating safer nuclear power plants. Considering the design of systems, the areas of weakness at the Fukushima nuclear power plants can be divided into three categories: plant protection, electricity supply, and cooling of the nuclear fuel. In this paper, focusing on these three areas, the lessons learned are proposed and applied for pressurized heavy water reactors. Firstly, hard protection against external risks ensures the integrity of components and systems such that they can perform their original functions. Secondly, additional emergency power supply systems for electrical redundancy and diversity can improve the response capabilities for an accident by increasing the availability of active components. Thirdly, cooling for removing decay heat can be augmented by adopting diverse safety systems derived from other types of reactors. This study is expected to contribute to the safety enhancement of pressurized heavy water reactors by applying design changes based on the lessons learned from the Fukushima accident.

  17. Gypsum plasterboards enhanced with phase change materials: A fire safety assessment using experimental and computational techniques

    Directory of Open Access Journals (Sweden)

    Kolaitis Dionysios I.

    2013-11-01

    Full Text Available Phase Change Materials (PCM can be used for thermal energy storage, aiming to enhance building energy efficiency. Recently, gypsum plasterboards with incorporated paraffin-based PCM blends have become commercially available. In the high temperature environment developed during a fire, the paraffins, which exhibit relatively low boiling points, may evaporate and, escaping through the gypsum plasterboard's porous structure, emerge to the fire region, where they may ignite, thus adversely affecting the fire resistance characteristics of the building. Aiming to assess the fire safety behaviour of such building materials, an extensive experimental and computational analysis is performed. The fire behaviour and the main thermo-physical physical properties of PCM-enhanced gypsum plasterboards are investigated, using a variety of standard tests and devices (Scanning Electron Microscopy, Thermo Gravimetric Analysis, Cone Calorimeter. The obtained results are used to develop a dedicated numerical model, which is implemented in a CFD code. CFD simulations are validated using measurements obtained in a cone calorimeter. In addition, the CFD code is used to simulate an ISO 9705 room exposed to fire conditions, demonstrating that PCM addition may indeed adversely affect the fire safety of a gypsum plasterboard clad building.

  18. Reliability-based server selection for heterogeneous VANETs

    Directory of Open Access Journals (Sweden)

    Seyedali Hosseininezhad

    2011-09-01

    Full Text Available Heterogeneous wireless networks are capable of providing customers with better services while service providers can offer more applications to more customers with lower costs. To provide services, some applications rely on existing servers in the network. In a vehicular ad-hoc network (VANET some mobile nodes may function as servers. Due to high mobility of nodes and short lifetime of links, server-to-client and server-to-server communications become challenging. In this paper we propose to enhance the performance of server selection by taking link reliability into consideration in the server selection mechanism, thereby avoiding extra client-to-server hand-offs and reducing the need of server-to-server synchronization. As a case study we focus on location management service in a heterogeneous VANET. We provide a routing algorithm for transactions between location servers and mobile nodes. We assume that location servers are vehicles equipped with at least one long- range and one short-range radio interfaces, whereas regular nodes (clients are only equipped with a short-range radio interface. The primary goal of our design is to minimize hand-offs between location servers while limiting the delays of location updates. Taking advantage of vehicle mobility patterns, we propose a mobility-aware server selection scheme and show that it can reduce the number of hand-offs and yet avoid large delays during location updates. We present simulation results to show that proposed scheme significantly lowers the costs of signaling and rate of server hand-offs by increasing the connection lifetimes between clients and servers.

  19. Reliability-Based Topology Optimization Using Stochastic Response Surface Method with Sparse Grid Design

    Directory of Open Access Journals (Sweden)

    Qinghai Zhao

    2015-01-01

    Full Text Available A mathematical framework is developed which integrates the reliability concept into topology optimization to solve reliability-based topology optimization (RBTO problems under uncertainty. Two typical methodologies have been presented and implemented, including the performance measure approach (PMA and the sequential optimization and reliability assessment (SORA. To enhance the computational efficiency of reliability analysis, stochastic response surface method (SRSM is applied to approximate the true limit state function with respect to the normalized random variables, combined with the reasonable design of experiments generated by sparse grid design, which was proven to be an effective and special discretization technique. The uncertainties such as material property and external loads are considered on three numerical examples: a cantilever beam, a loaded knee structure, and a heat conduction problem. Monte-Carlo simulations are also performed to verify the accuracy of the failure probabilities computed by the proposed approach. Based on the results, it is demonstrated that application of SRSM with SGD can produce an efficient reliability analysis in RBTO which enables a more reliable design than that obtained by DTO. It is also found that, under identical accuracy, SORA is superior to PMA in view of computational efficiency.

  20. Outline of the Fukushima Daiichi Accident. Lessons Learned and Safety Enhancements

    Science.gov (United States)

    Hirano, Masashi

    2017-09-01

    Abstract. On March 11, 2011, an earthquake and subsequent tsunamis off the Pacific coastline of Japan's Tohoku region caused widespread devastation in Japan. As of June 10, 2016, it is reported that a total of 15,894 people lost their lives and 2,558 people are still unaccounted for. In Fukushima Prefecture, approximately 100,000 people are still obliged to live away from their homes due to the earthquake and tsunami as well as the Fukushima Daiichi accident. On the day, the earthquake and tsunami caused severe damages to the Tokyo Electric Power Company (TEPCO)'s Fukushima Daiichi Nuclear Power Station (NPS). All the units in operation, namely Units 1 to 3, were automatically shut down on seismic reactor protection system trips but the earthquake led to the loss of all off-site electrical power supplies to that site. The subsequent tsunami inundated the site up to 4 to 5 m above its ground level and caused, in the end, the loss of core cooling function in Units 1 to 3, resulting in severe core damages and containment vessel failures in these three units. Hydrogen was released from the containment vessels, leading to explosions in the reactor buildings of Units 1, 3 and 4. Radioactive materials were released to the atmosphere and were deposited on the land and in the ocean. One of the most important lessons learned is an importance to prevent such large scale common cause failures due to extreme natural events. This leads to a conclusion that application of the defense-in-depth philosophy be enhanced because the defense-in-depth philosophy has been and continues to be an effective way to account for uncertainties associated with risks. From the human and organizational viewpoints, the final report from the Investigation Committee of the Government pointed out so-called "safety myth" that existed among nuclear operators including TEPCO as well as the government, that serious severe accidents could never occur in nuclear power plants in Japan. After the accident, the

  1. Thermal safety of ultrasound-enhanced ocular drug delivery: A modeling study

    Energy Technology Data Exchange (ETDEWEB)

    Nabili, Marjan, E-mail: mnabili@gwmail.gwu.edu [Department of Electrical and Computer Engineering, The George Washington University, 800 22nd Street NW, Room 5000, Washington, DC 20052 (United States); Geist, Craig, E-mail: cgeist@mfa.gwu.edu, E-mail: zderic@gwu.edu [Department of Ophthalmology, The George Washington University, 2150 Pennsylvania Avenue NW, Floor 2A, Washington, DC 20037 (United States); Zderic, Vesna, E-mail: cgeist@mfa.gwu.edu, E-mail: zderic@gwu.edu [Department of Biomedical Engineering, The George Washington University, 800 22nd Street NW, Room 6670, Washington, DC 20052 (United States)

    2015-10-15

    Purpose: Delivery of sufficient amounts of therapeutic drugs into the eye for treatment of various ocular diseases is often a challenging task. Ultrasound was shown to be effective in enhancing ocular drug delivery in the authors’ previous in vitro and in vivo studies. Methods: The study reported here was designed to investigate the safety of ultrasound application and its potential thermal effects in the eye using PZFlex modeling software. The safety limit in this study was set as a temperature increase of no more than 1.5 °C based on regulatory recommendations and previous experimental safety studies. Acoustic and thermal specifications of different human eye tissues were obtained from the published literature. The tissues of particular interest in this modeling safety study were cornea, lens, and the location of optic nerve in the posterior eye. Ultrasound application was modeled at frequencies of 400 kHz–1 MHz, intensities of 0.3–1 W/cm{sup 2}, and exposure duration of 5 min, which were the parameters used in the authors’ previous drug delivery experiments. The baseline eye temperature was 37 °C. Results: The authors’ results showed that the maximal tissue temperatures after 5 min of ultrasound application were 38, 39, 39.5, and 40 °C in the cornea, 39.5, 40, 42, and 43 °C in the center of the lens, and 37.5, 38.5, and 39 °C in the back of the eye (at the optic nerve location) at frequencies of 400, 600, 800 kHz, and 1 MHz, respectively. Conclusions: The ocular temperatures reached at higher frequencies were considered unsafe based on current recommendations. At a frequency of 400 kHz and intensity of 0.8 W/cm{sup 2} (parameters shown in the authors’ previous in vivo studies to be optimal for ocular drug delivery), the temperature increase was small enough to be considered safe inside different ocular tissues. However, the impact of orbital bone and tissue perfusion should be included in future modeling efforts to determine the safety

  2. Enhancement of the safety of live influenza vaccine by attenuating mutations from cold-adapted hemagglutinin

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yoon Jae [Graduate Program in Biomaterials Science and Engineering, College of Life Science and Biotechnology, Yonsei University, Seoul (Korea, Republic of); Laboratory of Molecular Medicine, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul (Korea, Republic of); Vaccine Translational Research Center, Yonsei University, Seoul (Korea, Republic of); Jang, Yo Han [Laboratory of Molecular Medicine, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul (Korea, Republic of); Kim, Paul; Lee, Yun Ha; Lee, Young Jae [Laboratory of Molecular Medicine, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul (Korea, Republic of); Vaccine Translational Research Center, Yonsei University, Seoul (Korea, Republic of); Byun, Young Ho; Lee, Kwang-Hee; Kim, Kyusik [Laboratory of Molecular Medicine, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul (Korea, Republic of); Seong, Baik Lin, E-mail: blseong@yonsei.ac.kr [Graduate Program in Biomaterials Science and Engineering, College of Life Science and Biotechnology, Yonsei University, Seoul (Korea, Republic of); Laboratory of Molecular Medicine, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul (Korea, Republic of); Vaccine Translational Research Center, Yonsei University, Seoul (Korea, Republic of)

    2016-04-15

    In our previous study, X-31ca-based H5N1 LAIVs, in particular, became more virulent in mice than the X-31ca MDV, possibly by the introduction of the surface antigens of highly pathogenic H5N1 influenza virus, implying that additional attenuation is needed in this cases to increase the safety level of the vaccine. In this report we suggest an approach to further increase the safety of LAIV through additional cold-adapted mutations in the hemagglutinin. The cold-adaptation of X-31 virus resulted in four amino acid mutations in the HA. We generated a panel of 7:1 reassortant viruses each carrying the hemagglutinins with individual single amino acid mutations. We examined their phenotypes and found a major attenuating mutation, N81K. This attenuation marker conferred additional temperature-sensitive and attenuation phenotype to the LAIV. Our data indicate that the cold-adapted mutation in the HA confers additional attenuation to the LAIV strain, without compromising its productivity and immune response. - Highlights: • Cold-adaptation process induced four amino acid mutations in the HA of X-31 virus. • The four mutations in the HA also contributed to attenuation of the X-31ca virus • N81K mutation was the most significant marker for the attenuation of X-31ca virus. • Introduction of N81K mutation into H3N2 LAIV further attenuated the vaccine. • This approach provides a useful guideline for enhancing the safety of the LAIVs.

  3. The need to optimize inservice testing and inspection to enhance safety

    Energy Technology Data Exchange (ETDEWEB)

    Perry, J.A.

    1996-12-01

    Welcome to the Fourth U.S. Nuclear Regulatory Commission and American Society of Mechanical Engineers (USNRC/ASME) Symposium on Valve and Pump Testing in Nuclear Power Plants. This symposium provides a forum to exchange information on technical and regulatory issues associated with the testing of valves and pumps used in nuclear power plants. Progress made since the last symposium will be discussed along with various methods for in service testing of valves and pumps. Active participation by industry representatives, regulators and consultants will entail discussion of a broad array of ideas and points of view regarding how to improve the in service testing of valves and pumps at nuclear power plants. One of the challenges faced is the need to optimize the in service testing and inspection to enhance safety, operability and reliability. The author addresses this challenge from an ASME Nuclear Codes and Standards point of view.

  4. An efficient RFID authentication protocol to enhance patient medication safety using elliptic curve cryptography.

    Science.gov (United States)

    Zhang, Zezhong; Qi, Qingqing

    2014-05-01

    Medication errors are very dangerous even fatal since it could cause serious even fatal harm to patients. In order to reduce medication errors, automated patient medication systems using the Radio Frequency Identification (RFID) technology have been used in many hospitals. The data transmitted in those medication systems is very important and sensitive. In the past decade, many security protocols have been proposed to ensure its secure transition attracted wide attention. Due to providing mutual authentication between the medication server and the tag, the RFID authentication protocol is considered as the most important security protocols in those systems. In this paper, we propose a RFID authentication protocol to enhance patient medication safety using elliptic curve cryptography (ECC). The analysis shows the proposed protocol could overcome security weaknesses in previous protocols and has better performance. Therefore, the proposed protocol is very suitable for automated patient medication systems.

  5. Enhanced safety in the storage of fissile materials. [Boron-loaded epoxy resin

    Energy Technology Data Exchange (ETDEWEB)

    Williams, G.E.; Alvares, N.J.

    1978-12-15

    An inexpensive boron-loaded liner of epoxy resin for fissile-material storage containers was developed that can be easily fabricated of readily available, low-cost materials. Computer calculations indicate reactivity will be reduced substantially if this neutron-absorbing liner is added to containers in a typical storage array. These calculations compare favorably with neutron-attenuation experiments with thermal and fission neutron spectra, and tests at the Fire Test Facility indicate the epoxy resin will survive extreme environmental and accident conditions. The fire-resistant and insulating properties of the epoxy-resin liner further augment its ability to protect fissile materials. Boron-loaded epoxy resin is adaptable to many tasks but is particularly useful for providing enhanced criticality safety in the packaging and storage of fissile materials.

  6. Criticality safety evaluation for the Advanced Test Reactor enhanced low enriched uranium fuel elements

    Energy Technology Data Exchange (ETDEWEB)

    Montierth, Leland M. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-07-19

    The Global Threat Reduction Initiative (GTRI) convert program is developing a high uranium density fuel based on a low enriched uranium (LEU) uranium-molybdenum alloy. Testing of prototypic GTRI fuel elements is necessary to demonstrate integrated fuel performance behavior and scale-up of fabrication techniques. GTRI Enhanced LEU Fuel (ELF) elements based on the ATR-Standard Size elements (all plates fueled) are to be fabricated for testing in the Advanced Test Reactor (ATR). While a specific ELF element design will eventually be provided for detailed analyses and in-core testing, this criticality safety evaluation (CSE) is intended to evaluate a hypothetical ELF element design for criticality safety purposes. Existing criticality analyses have analyzed Standard (HEU) ATR elements from which controls have been derived. This CSE documents analysis that determines the reactivity of the hypothetical ELF fuel elements relative to HEU ATR elements and whether the existing HEU ATR element controls bound the ELF element. The initial calculations presented in this CSE analyzed the original ELF design, now referred to as Mod 0.1. In addition, as part of a fuel meat thickness optimization effort for reactor performance, other designs have been evaluated. As of early 2014 the most current conceptual designs are Mk1A and Mk1B, that were previously referred to as conceptual designs Mod 0.10 and Mod 0.11, respectively. Revision 1 evaluates the reactivity of the ATR HEU Mark IV elements for a comparison with the Mark VII elements.

  7. Thermal-Responsive Polymers for Enhancing Safety of Electrochemical Storage Devices.

    Science.gov (United States)

    Yang, Hui; Leow, Wan Ru; Chen, Xiaodong

    2018-01-24

    Thermal runway constitutes the most pressing safety issue in lithium-ion batteries and supercapacitors of large-scale and high-power density due to risks of fire or explosion. However, traditional strategies for averting thermal runaway do not enable the charging-discharging rate to change according to temperature or the original performance to resume when the device is cooled to room temperature. To efficiently control thermal runaway, thermal-responsive polymers provide a feasible and reversible strategy due to their ability to sense and subsequently act according to a predetermined sequence when triggered by heat. Herein, recent research progress on the use of thermal-responsive polymers to enhance the thermal safety of electrochemical storage devices is reviewed. First, a brief discussion is provided on the methods of preventing thermal runaway in electrochemical storage devices. Subsequently, a short review is provided on the different types of thermal-responsive polymers that can efficiently avoid thermal runaway, such as phase change polymers, polymers with sol-gel transitions, and polymers with positive temperature coefficients. The results represent the important development of thermal-responsive polymers toward the prevention of thermal runaway in next-generation smart electrochemical storage devices. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Enhancement of Fire Safety of an Existing Green Building due to Natural Ventilation

    Directory of Open Access Journals (Sweden)

    Hong Sheng Huang

    2016-03-01

    Full Text Available In recent years, natural ventilation technology is extensively used in order to improve indoor environment quality and reduce power consumption of air-conditioning systems in green buildings. However, the effect of natural ventilation on fires needs to be evaluated carefully, and how to make these energy-saving buildings safe is a topic worth studying. This study uses Fire Dynamics Simulator on some fire safety enhancement measures for an existing green building without installation of a smoke exhaust system. Since the building is located on a school campus, it does not require a smoke exhaust system according to Taiwan fire regulations. Referential results, obtained after a series of improvement strategies are tested, show that kiln natural ventilation can generate a comfortable air flow. Unfortunately, due to the stack effect, hot air and fatal smoke are blown into the evacuation route area behind the room when a fire occurs. The findings showed that there are two feasible improvement measures, “controlling the off state of each air inlet” and “setting up an exhaust port in the rear of room”, which can effectively resolve the fire safety issues; the construction of which can be undertaken at a reasonable cost.

  9. A knee-mounted biomechanical energy harvester with enhanced efficiency and safety

    Science.gov (United States)

    Chen, Chao; Chau, Li Yin; Liao, Wei-Hsin

    2017-06-01

    Energy harvesting is becoming a major limiting issue for many portable devices. When undertaking any activity, the human body generates a significant amount of biomechanical energy, which can be collected by means of a portable energy harvester. This energy provides a method of powering portable devices such as prosthetic limbs. In this paper, a knee-mounted energy harvester with enhanced efficiency and safety is proposed and developed to convert mechanical energy into electricity during human motion. This device can change the bi-directional knee input into uni-directional rotation for an electromagnetic generator using a specially designed transmission system. Without the constraint of induced impact on the human body, this device can harvest biomechanical energy from both knee flexion and extension, improving the harvesting efficiency over previous single-direction energy harvesters. It can also provide protection from device malfunction, and increase the safety of current biomechanical energy harvesters. A highly compact and light prototype is developed taking into account human kinematics. The biomechanical energy harvesting system is also modeled and analyzed. The prototype is tested under different conditions including walking, running and climbing stairs, to evaluate the energy harvesting performance and effect on the human gait. The experimental results show that the prototype can harvest an average power of 3.6 W at 1.5 m s-1 walking speed, which is promising for portable electronic devices.

  10. Reliability-based structural optimization using response surface approximations and probabilistic sufficiency factor

    Science.gov (United States)

    Qu, Xueyong

    Uncertainties exist practically everywhere from structural design to manufacturing, product lifetime service, and maintenance. Uncertainties can be introduced by errors in modeling and simulation; by manufacturing imperfections (such as variability in material properties and structural geometric dimensions); and by variability in loading. Structural design by safety factors using nominal values without considering uncertainties may lead to designs that are either unsafe, or too conservative and thus not efficient. The focus of this dissertation is reliability-based design optimization (RBDO) of composite structures. Uncertainties are modeled by the probabilistic distributions of random variables. Structural reliability is evaluated in term of the probability of failure. RBDO minimizes cost such as structural weight subject to reliability constraints. Since engineering structures usually have multiple failure modes, Monte Carlo simulation (MCS) was used employed to calculate the system probability of failure. Response surface (RS) approximation techniques were used to solve the difficulties associated with MCS. The high computational cost of a large number of MCS samples was alleviated by analysis RS, and numerical noise in the results of MCS was filtered out by design RS. RBDO of composite laminates is investigated for use in hydrogen tanks in cryogenic environments. The major challenge is to reduce the large residual strains developed due to thermal mismatch between matrix and fibers while maintaining the load carrying capacity. RBDO is performed to provide laminate designs, quantify the effects of uncertainties on the optimum weight, and identify those parameters that have the largest influence on optimum design. Studies of weight and reliability tradeoffs indicate that the most cost-effective measure for reducing weight and increasing reliability is quality control. A probabilistic sufficiency factor (PSF) approach was developed to improve the computational

  11. Drug Repositioning of Proton Pump Inhibitors for Enhanced Efficacy and Safety of Cancer Chemotherapy

    Directory of Open Access Journals (Sweden)

    Kenji Ikemura

    2017-12-01

    Full Text Available Proton pump inhibitors (PPIs, H+/K+-ATPase inhibitors, are the most commonly prescribed drugs for the treatment of gastroesophageal reflux and peptic ulcer diseases; they are highly safe and tolerable. Since PPIs are frequently used in cancer patients, studies investigating interactions between PPIs and anticancer agents are of particular importance to achieving effective and safe cancer chemotherapy. Several studies have revealed that PPIs inhibit not only the H+/K+-ATPase in gastric parietal cells, but also the vacuolar H+-ATPase (V-ATPase overexpressed in tumor cells, as well as the renal basolateral organic cation transporter 2 (OCT2 associated with pharmacokinetics and/or renal accumulation of various drugs, including anticancer agents. In this mini-review, we summarize the current knowledge regarding the impact of PPIs on the efficacy and safety of cancer chemotherapeutics via inhibition of targets other than the H+/K+-ATPase. Co-administration of clinical doses of PPIs protected kidney function in patients receiving cisplatin and fluorouracil, presumably by decreasing accumulation of cisplatin in the kidney via OCT2 inhibition. In addition, co-administration or pretreatment with PPIs could inhibit H+ transport via the V-ATPase in tumor cells, resulting in lower extracellular acidification and intracellular acidic vesicles to enhance the sensitivity of the tumor cells to the anticancer agents. In the present mini-review, we suggest that PPIs enhance the efficacy and safety of anticancer agents via off-target inhibition (e.g., of OCT2 and V-ATPase, rather than on-target inhibition of the H+/K+-ATPase. The present findings should provide important information to establish novel supportive therapy with PPIs during cancer chemotherapy.

  12. Creating an improvement culture for enhanced patient safety: service improvement learning in pre-registration education.

    Science.gov (United States)

    Christiansen, Angela; Robson, Linda; Griffith-Evans, Christine

    2010-10-01

    The present study reports a descriptive survey of nursing students' experience of service improvement learning in the university and practice setting. Opportunities to develop service improvement capabilities were embedded into pre-registration programmes at a university in the Northwest of England to ensure future nurses have key skills for the workplace. A cross-sectional survey designed to capture key aspects of students' experience was completed by nursing students (n = 148) who had undertaken a service improvement project in the practice setting. Work organizations in which a service improvement project was undertaken were receptive to students' efforts. Students reported increased confidence to undertake service improvement and service improvement capabilities were perceived to be important to future career development and employment prospects. Service improvement learning in pre-registration education appears to be acceptable, effective and valued by students. Further research to identify the impact upon future professional practice and patient outcomes would enhance understanding of this developing area. Nurse Managers can play an active role in creating a service culture in which innovation and improvement can flourish to enhance patient outcomes, experience and safety. © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.

  13. [Microcystin safety study during Cyanobacteria removal by pressure enhanced coagulation process].

    Science.gov (United States)

    Jiang, Xin-Yue; Luan, Qing; Cong, Hai-Bing; Xu, Si-Tao; Liu, Yu-Jiao; Zhu, Xue-Yuan

    2014-11-01

    Pressure enhanced coagulation and sedimentation technique is an effective way for blue algae treatment. It is not clear whether Cyanobacteria balloon rupture will cause Cyanobacteria cells rupture, resulting in high intracellular concentrations of microcystin LR leak into the water, affecting drinking water safety. Therefore, in this study experimental comparative study of pressure and pre-oxidation of water containing Cyanobacteria was carried out to examine the microcystin LR concentration changes and Cyanobacteria removal efficiency. The results showed that microcystin concentration increase was not significant by the pre-treatment with Cyanobacteria water pressure, while the pre-oxidation process caused a significant increase in the concentration of microcystin. After 0.5-0.8 MPa pressure coagulation and sedimentation, removal of Cyanobacteria basically was over 90%, up to 93.5%, while the removal rate by pre-oxidation was low and unstable. Effluent turbidity is also significantly better in the pre-pressure method than the pre-oxidation. The results indicated that pressure enhanced coagulation is a safe and reliable method for Cyanobacteria removal.

  14. Assessment of a Conceptual Flap System Intended for Enhanced General Aviation Safety

    Science.gov (United States)

    Campbell, Bryan A.; Carter, Melissa B.

    2017-01-01

    A novel multielement trailing-edge flap system for light general aviation airplanes was conceived for enhanced safety during normal and emergency landings. The system is designed to significantly reduce stall speed, and thus approach speed, with the goal of reducing maneuveringflight accidents and enhancing pilot survivability in the event of an accident. The research objectives were to assess the aerodynamic performance characteristics of the system and to evaluate the extent to which it provided both increased lift and increased drag required for the low-speed landing goal. The flap system was applied to a model of a light general aviation, high-wing trainer and tested in the Langley 12- Foot Low-Speed Wind Tunnel. Data were obtained for several device deflection angles, and component combinations at a dynamic pressure of 4 pounds per square foot. The force and moment data supports the achievement of the desired increase in lift with substantially increased drag, all at relatively shallow angles of attack. The levels of lift and drag can be varied through device deflection angles and inboard/outboard differential deflections. As such, it appears that this flap system may provide an enabling technology to allow steep, controllable glide slopes for safe rapid descent to landing with reduced stall speed. However, a simple flat-plate lower surface spoiler (LSS) provided either similar or superior lift with little impact on pitch or drag as compared to the proposed system. Higher-fidelity studies are suggested prior to use of the proposed system.

  15. Neutron-Absorbing Coatings for Safe Storage of Fissile Materials with Enhanced Shielding & Criticality Safety

    Energy Technology Data Exchange (ETDEWEB)

    Choi, J; Farmer, J; Lee, C; Fischer, L; Boussoufi, M; Liu, B; Egbert, H

    2007-07-03

    Neutron-absorbing Fe-based amorphous-metal coatings have been developed that are more corrosion resistant than other criticality-control materials, including Al-B{sub 4}C composites, borated stainless steels, and Ni-Cr-Mo-Gd alloys. The presence of relatively high concentration of boron in these coatings not only enhances its neutron-absorption capability, but also enables these coatings to exist in the amorphous state. Exceptional corrosion resistance has been achieved with these Fe-based amorphous-metal alloys through additions of chromium, molybdenum, and tungsten. The addition of rare earth elements such as yttrium has lowered the critical cooling rate of these materials, thereby rendering them more easily processed. Containers used for the storage of nuclear materials, and protected from corrosion through the application of amorphous metal coatings, would have greatly enhanced service lives, and would therefore provide greater long-term safety. Amorphous alloy powders have been successfully produced in multi-ton quantities with gas atomization, and applied to several half-scale spent fuel storage containers and criticality control structures with the high-velocity oxy-fuel (HVOF) thermal spray process. Salt fog testing and neutron radiography of these prototypes indicates that such an approach is viable for the production of large-scale industrial-scale facilities and containers. The use of these durable neutron-absorbing materials to coat stainless steel containers and storage racks, as well as vaults, hot-cell facilities and glove boxes could substantially reduce the risk of criticality in the event of an accident. These materials are particularly attractive for shielding applications since they are fire proof. Additionally, layers of other cold and thermal sprayed materials that include carbon and/or carbides can be used in conjunction with the high-boron amorphous metal coatings for the purpose of moderation. For example, various carbides, including boron

  16. SAFETY

    CERN Multimedia

    C. Schaefer and N. Dupont

    2013-01-01

      “Safety is the highest priority”: this statement from CERN is endorsed by the CMS management. An interpretation of this statement may bring you to the conclusion that you should stop working in order to avoid risks. If the safety is the priority, work is not! This would be a misunderstanding and misinterpretation. One should understand that “working safely” or “operating safely” is the priority at CERN. CERN personnel are exposed to different hazards on many levels on a daily basis. However, risk analyses and assessments are done in order to limit the number and the gravity of accidents. For example, this process takes place each time you cross the road. The hazard is the moving vehicle, the stake is you and the risk might be the risk of collision between both. The same principle has to be applied during our daily work. In particular, keeping in mind the general principles of prevention defined in the late 1980s. These principles wer...

  17. SAFETY

    CERN Document Server

    M. Plagge, C. Schaefer and N. Dupont

    2013-01-01

    Fire Safety – Essential for a particle detector The CMS detector is a marvel of high technology, one of the most precise particle measurement devices we have built until now. Of course it has to be protected from external and internal incidents like the ones that can occur from fires. Due to the fire load, the permanent availability of oxygen and the presence of various ignition sources mostly based on electricity this has to be addressed. Starting from the beam pipe towards the magnet coil, the detector is protected by flooding it with pure gaseous nitrogen during operation. The outer shell of CMS, namely the yoke and the muon chambers are then covered by an emergency inertion system also based on nitrogen. To ensure maximum fire safety, all materials used comply with the CERN regulations IS 23 and IS 41 with only a few exceptions. Every piece of the 30-tonne polyethylene shielding is high-density material, borated, boxed within steel and coated with intumescent (a paint that creates a thick co...

  18. A Lithium-Ion Battery with Enhanced Safety Prepared using an Environmentally Friendly Process.

    Science.gov (United States)

    Mueller, Franziska; Loeffler, Nicholas; Kim, Guk-Tae; Diemant, Thomas; Behm, R Jürgen; Passerini, Stefano

    2016-06-08

    A new lithium-ion battery chemistry is presented based on a conversion-alloying anode material, a carbon-coated Fe-doped ZnO (TMO-C), and a LiNi1/3 Mn1/3 Co1/3 O2 (NMC) cathode. Both electrodes were fabricated using an environmentally friendly cellulose-based binding agent. The performance of the new lithium-ion battery was evaluated with a conventional, carbonate-based electrolyte (ethylene carbonate:diethyl carbonate-1 m lithium hexafluorophosphate, EC:DEC 1 m LiPF6 ) and an ionic liquid (IL)-based electrolyte (N-butyl-N-methylpyrrolidinium bis(trifluoromethanesulfonyl)imide-0.2 m lithium bis(trifluoromethanesulfonyl)imide, Pyr14 TFSI 0.2 m LiTFSI), respectively. Galvanostatic charge/discharge tests revealed a reduced rate capability of the TMO-C/Pyr14 TFSI 0.2 m LiTFSI/NMC full-cell compared to the organic electrolyte, but the coulombic efficiency was significantly enhanced. Moreover, the IL-based electrolyte substantially improves the safety of the system due to a higher thermal stability of the formed anodic solid electrolyte interphase and the IL electrolyte itself. While the carbonate-based electrolyte shows sudden degradation reactions, the IL exhibits a slowly increasing heat flow, which does not constitute a serious safety risk. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Non-technical skills training to enhance patient safety: a systematic review.

    Science.gov (United States)

    Gordon, Morris; Darbyshire, Daniel; Baker, Paul

    2012-11-01

    Many quality improvement education programmes have been introduced over the last decade with the purpose of enhancing patient safety. The importance of non-technical skills training is becoming increasingly prominent, but the extent to which educational interventions have been used and the theoretical underpinnings of such interventions remain unclear. These issues were investigated through a systematic review of the literature. Any studies involving an educational intervention to improve non-technical skills amongst undergraduate or postgraduate staff in an acute health care environment were considered. A standardised search of online databases was carried out independently by two authors and consensus reached on the inclusion of studies. Data extraction and multimodal quality assessment were completed independently, followed by a content analysis of interventions and the extraction of key themes. A total of 22 studies met the inclusion criteria. Measured outcomes were variable, as was the strength of conclusions. Theoretical underpinning of interventions was not described in any studies. Content analysis revealed reasonable consistency with the emergence of five key themes: error; communication; teamwork and leadership; systems, and situational awareness. Teaching was often multidisciplinary and methods used included simulation and role-play exercises, and observation. The methodological quality of published studies is reasonable, although the reporting of specific interventions is poor. Although a recognised model to support the design of patient safety education is lacking, a number of theories have been applied to guide educators in future instructional design. Further published work should clearly describe interventions and their theoretical underpinnings, and should aim to further explore which specific aspects of interventions are effective and why. Such research should also try to assess whether such interventions can impact patient outcomes. © Blackwell

  20. Reliability Assessment and Reliability-Based Inspection and Maintenance of Offshore Wind Turbines

    DEFF Research Database (Denmark)

    Ramírez, José G. Rangel; Sørensen, John Dalsgaard

    2009-01-01

    to optimize inspection and maintenance (I&M) efforts, entailing to a suitable life-cycle performance without neglecting the economical aspect. Moreover, the integration of condition monitoring information (CMI) can be done through probabilistic inference. In this work, a reliability-based I&M planning OWT......Probabilistic methodologies represent an important tool to identify the suitable strategy to inspect and deal with the deterioration in structures such as offshore wind turbines (OWT). Reliability based methods such as Risk Based Inspection (RBI) planning may represent a proper methodology...

  1. 47{sup th} Annual meeting on nuclear technology (AMNT 2016). Key Topics / Enhanced safety and operation excellence

    Energy Technology Data Exchange (ETDEWEB)

    Bohnstedt, Angelika [Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany). Programm Nukleare Entsorgung, Sicherheit und Strahlenforschung (NUSAFE); Baumann, Erik [AREVA GmbH, Erlangen (Germany). Radiation Protection

    2016-12-15

    Summary report on the Key Topic 'Enhanced Safety and Operation Excellence' Focus Session 'Radiation Protection' of the 47{sup th} Annual Meeting on Nuclear Technology (AMNT 2016) held in Hamburg, 10 to 12 May 2016. Other Sessions of AMNT 2016 have been and will be covered in further issues of atw.

  2. 76 FR 6087 - Draft Weapons Safety Assessment on the Use of Enhanced Weapons; Notice of Availability and...

    Science.gov (United States)

    2011-02-03

    ... public, licensees, certificate holders, and other stakeholders on a draft guidance document entitled ``Weapons Safety Assessment'' (WSA). This guidance would be used by licensees and certificate holders... the use for enhanced weapons. The Commission is authorized under Section 161A of the Atomic Energy Act...

  3. Early communication of drug safety concerns: a feasibility study on enhancing interaction between the pharmaceutical industry and regulators.

    Science.gov (United States)

    Swain, Elizabeth; Morgan, Sarah; Brewster, Wendy; Kauser, Shahin

    2010-03-01

    The responsibility for monitoring the safety of marketed medicines is shared between regulatory authorities and the pharmaceutical industry and is underpinned by legal obligations on both sides. Both marketing authorisation holders (MAHs) and regulators initially evaluate and investigate potential safety concerns, and then work together on further review as appropriate. We wanted to test the feasibility of enhanced interaction between MAH and regulator via a regular monthly, two-way communication of potential safety concerns between the MAHs and the Medicines and Healthcare Products Regulatory Agency (MHRA). It was envisaged that such a process would aid prioritisation and planning by both parties, avoid duplication of effort and support a collaborative approach for decision making. Four MAHs took part in the pilot, which was conducted between July 2007 and June 2008. Potential safety concerns were exchanged on a monthly basis. The MAH/MHRA proposed a timeline for evaluation of each potential safety concern. The pilot did not include serious public health issues which are immediately reported to regulatory authorities. During the pilot, 136 potential safety concerns were exchanged. Thirteen per cent of these resulted in a change to product information for health professionals and patients. There was concurrence between the MAHs and MHRA on timelines proposed for evaluation. The pilot proved feasible for the companies involved and indicated potential benefits of a system for avoiding duplication of effort and supporting a collaborative approach to planning and prioritisation of investigation of potential safety concerns between pharmaceutical industry and regulatory authorities.

  4. Characterizing and enhancing the safety of future plastic and composite intensive vehicles (PCIVs).

    Science.gov (United States)

    2009-01-01

    There is concern that a trend toward smaller, lighter, fuel-efficient vehicles could adversely affect overall fleet safety. Since 2006, the U.S. Congress has directed the National Highway Traffic Safety Administration to examine the possible safet...

  5. A study of the international trend and comprehensive enhancement program on the Nuclear Power Plant safety

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Soon Hong; Cho, Nam Jin; Paek, Won Phil [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)] (and others)

    1990-12-15

    The objectives of this study are as follows : overview of the international trend related to the safety of Nuclear Power Plant(NPPs), study of the present status of NPP safety in Korea in aspects of design, construction and operation, suggestion of the comprehensive program to improve NPP safety in Korea. The results of this study can contribute to improve the safety of existing and future NPPs, and to establish the severe accident policy in Korea.

  6. Safety of an Enhanced Recovery Pathway for Patients Undergoing Open Hepatic Resection.

    Directory of Open Access Journals (Sweden)

    Clancy J Clark

    Full Text Available Enhanced recovery pathways (ERP have not been widely implemented for hepatic surgery. The aim of this study was to evaluate the safety of an ERP for patients undergoing open hepatic resection.A single-surgeon, retrospective observational cohort study was performed comparing the clinical outcomes of patients undergoing open hepatic resection treated before and after implementation of an ERP. Morbidity, mortality, and length of hospital stay (LOS were compared between pre-ERP and ERP groups.126 patients (pre-ERP n = 73, ERP n = 53 were identified for the study. Patient characteristics and operative details were similar between groups. Overall complication rate was similar between pre-ERP and ERP groups (37% vs. 28%, p = 0.343. Before and after pathway implementation, the median LOS was similar, 5 (IQR 4-7 vs. 5 (IQR 4-6 days, p = 0.708. After adjusting for age, type of liver resection, and ASA, the ERP group had no increased risk of major complication (OR 0.38, 95% CI 0.14-1.02, p = 0.055 or LOS greater than 5 days (OR 1.21, 95% CI 0.56-2.62, p = 0.627.Routine use of a multimodal ERP is safe and is not associated with increased postoperative morbidity after open hepatic resection.

  7. Enhancing Patient Safety: Factors Influencing Medical Error Recovery Among Medical-Surgical Nurses

    Science.gov (United States)

    Gaffney, Theresa A; Hatcher, Barbara J; Milligan, Renee; Trickey, Amber

    2016-09-30

    Keeping patients safe is a core nursing duty. The dynamic nature of the healthcare environment requires that nurses practice to the full extent of their education, experience, and role to keep patients safe. Research has focused on error causation rather than error recovery, a process that occurs before patient harm ensues. In addition, little is known about the role nurses play in error recovery. A descriptive cross-sectional, correlational study using a sample of 184 nurses examined relationships between nurse characteristics, organizational factors, and recovery of medical errors among medical-surgical nurses in hospitals. In this article, we provide background information to introduce the concept of error recovery, and present our study aims and methods. Study results suggested that medical-surgical nurses recovered on average 22 medical errors and error recovery was positively associated with education and expertise. The discussion section further considers the important role of medical-surgical nurses and error recovery to enhance patient safety. In conclusion, we suggest that creating a safer healthcare system will depend on the ability of nurses to fully use their education, expertise and role to identify, interrupt, and correct medical errors; thereby, preventing patient harm.

  8. Guidelines for Interactive Reliability-Based Structural Optimization using Quasi-Newton Algorithms

    DEFF Research Database (Denmark)

    Pedersen, C.; Thoft-Christensen, Palle

    Guidelines for interactive reliability-based structural optimization problems are outlined in terms of modifications of standard quasi-Newton algorithms. The proposed modifications minimize the condition number of the approximate Hessian matrix in each iteration, restrict the relative and absolute...

  9. Reliability-Based Optimization and Optimal Reliability Level of Offshore Wind Turbines

    DEFF Research Database (Denmark)

    2006-01-01

    Different formulations relevant for the reliability-based optimization of offshore wind turbines are presented, including different reconstruction policies in case of failure. Illustrative examples are presented and, as a part of the results, optimal reliability levels for the different failure...

  10. Reliability-Based Optimization and Optimal Reliability Level of Offshore Wind Turbines

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Tarp-Johansen, N.J.

    2005-01-01

    Different formulations relevant for the reliability-based optimization of offshore wind turbines are presented, including different reconstruction policies in case of failure. Illustrative examples are presented and, as a part of the results, optimal reliability levels for the different failure...

  11. An Educational Intervention to Enhance Nurse Leaders' Perceptions of Patient Safety Culture

    Science.gov (United States)

    Ginsburg, Liane; Norton, Peter G; Casebeer, Ann; Lewis, Steven

    2005-01-01

    Objective To design a training intervention and then test its effect on nurse leaders' perceptions of patient safety culture. Study Setting Three hundred and fifty-six nurses in clinical leadership roles (nurse managers and educators/CNSs) in two Canadian multi-site teaching hospitals (study and control). Study Design A prospective evaluation of a patient safety training intervention using a quasi-experimental untreated control group design with pretest and posttest. Nurses in clinical leadership roles in the study group were invited to participate in two patient safety workshops over a 6-month period. Individuals in the study and control groups completed surveys measuring patient safety culture and leadership for improvement prior to training and 4 months following the second workshop. Extraction Methods Individual nurse clinical leaders were the unit of analysis. Exploratory factor analysis of the safety culture items was conducted; repeated-measures analysis of variance and paired t-tests were used to evaluate the effect of the training intervention on perceived safety culture (three factors). Hierarchical regression analyses looked at the influence of demographics, leadership for improvement, and the training intervention on nurse leaders' perceptions of safety culture. Principal Findings A statistically significant improvement in one of three safety culture measures was shown for the study group (pLeadership support for improvement was found to explain significant amounts of variance in all three patient safety culture measures; workshop attendance explained significant amounts of variance in one of the three safety culture measures. The total R2 for the three full hierarchical regression models ranged from 0.338 and 0.554. Conclusions Sensitively delivered training initiatives for nurse leaders can help to foster a safety culture. Organizational leadership support for improvement is, however, also critical for fostering a culture of safety. Together, training

  12. 78 FR 66420 - Proposed Enhancements to the Motor Carrier Safety Measurement System (SMS) Public Web Site

    Science.gov (United States)

    2013-11-05

    ..., the SMS provides the motor carrier industry and other safety stakeholders with more comprehensive... and Fitness Electronic Records System (SAFER) Web site. Displaying current insurance and authority...

  13. Workflow enhancement (WE) improves safety in radiation oncology: putting the WE and team together.

    Science.gov (United States)

    Chao, Samuel T; Meier, Tim; Hugebeck, Brian; Reddy, Chandana A; Godley, Andrew; Kolar, Matt; Suh, John H

    2014-07-15

    To review the impact of a workflow enhancement (WE) team in reducing treatment errors that reach patients within radiation oncology. It was determined that flaws in our workflow and processes resulted in errors reaching the patient. The process improvement team (PIT) was developed in 2010 to reduce errors and was later modified in 2012 into the current WE team. Workflow issues and solutions were discussed in PIT and WE team meetings. Due to tensions within PIT that resulted in employee dissatisfaction, there was a 6-month hiatus between the end of PIT and initiation of the renamed/redesigned WE team. In addition to the PIT/WE team forms, the department had separate incident forms to document treatment errors reaching the patient. These incident forms are rapidly reviewed and monitored by our departmental and institutional quality and safety groups, reflecting how seriously these forms are treated. The number of these incident forms was compared before and after instituting the WE team. When PIT was disbanded, a number of errors seemed to occur in succession, requiring reinstitution and redesign of this team, rebranded the WE team. Interestingly, the number of incident forms per patient visits did not change when comparing 6 months during the PIT, 6 months during the hiatus, and the first 6 months after instituting the WE team (P=.85). However, 6 to 12 months after instituting the WE team, the number of incident forms per patient visits decreased (P=.028). After the WE team, employee satisfaction and commitment to quality increased as demonstrated by Gallup surveys, suggesting a correlation to the WE team. A team focused on addressing workflow and improving processes can reduce the number of errors reaching the patient. Time is necessary before a reduction in errors reaching patients will be seen. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. Workflow Enhancement (WE) Improves Safety in Radiation Oncology: Putting the WE and Team Together

    Energy Technology Data Exchange (ETDEWEB)

    Chao, Samuel T., E-mail: chaos@ccf.org [Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (United States); Rose Ella Burkhardt Brain Tumor and Neuro-oncology Center, Cleveland Clinic, Cleveland, Ohio (United States); Meier, Tim; Hugebeck, Brian; Reddy, Chandana A.; Godley, Andrew; Kolar, Matt [Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (United States); Suh, John H. [Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (United States); Rose Ella Burkhardt Brain Tumor and Neuro-oncology Center, Cleveland Clinic, Cleveland, Ohio (United States)

    2014-07-15

    Purpose: To review the impact of a workflow enhancement (WE) team in reducing treatment errors that reach patients within radiation oncology. Methods and Materials: It was determined that flaws in our workflow and processes resulted in errors reaching the patient. The process improvement team (PIT) was developed in 2010 to reduce errors and was later modified in 2012 into the current WE team. Workflow issues and solutions were discussed in PIT and WE team meetings. Due to tensions within PIT that resulted in employee dissatisfaction, there was a 6-month hiatus between the end of PIT and initiation of the renamed/redesigned WE team. In addition to the PIT/WE team forms, the department had separate incident forms to document treatment errors reaching the patient. These incident forms are rapidly reviewed and monitored by our departmental and institutional quality and safety groups, reflecting how seriously these forms are treated. The number of these incident forms was compared before and after instituting the WE team. Results: When PIT was disbanded, a number of errors seemed to occur in succession, requiring reinstitution and redesign of this team, rebranded the WE team. Interestingly, the number of incident forms per patient visits did not change when comparing 6 months during the PIT, 6 months during the hiatus, and the first 6 months after instituting the WE team (P=.85). However, 6 to 12 months after instituting the WE team, the number of incident forms per patient visits decreased (P=.028). After the WE team, employee satisfaction and commitment to quality increased as demonstrated by Gallup surveys, suggesting a correlation to the WE team. Conclusions: A team focused on addressing workflow and improving processes can reduce the number of errors reaching the patient. Time is necessary before a reduction in errors reaching patients will be seen.

  15. ENHANCED PROACTIVE PLANNING APPROACH: A CRUCIAL TO AN IMPROVED WORKERS’ SAFETY IN WESTERN NIGERIA SMALL SCALE INDUSTRY

    Directory of Open Access Journals (Sweden)

    H.O. ADEYEMI

    2016-12-01

    Full Text Available This study evaluated managements’ proactive planning approach (PPA to enhance safety among workers in South-western Nigeria small scale industry (SSI. The main objective was to rate the managements’ efforts at eliminating risk among their employees. By worker participatory and psychological survey approach, three tools were used; workplace observation (visual, management safety culture (questionnaire and managers interviews (oral. The survey included 200 workers, 120 supervisors and 80 managers, in 82 SSI. Four steps to a safety proactive action plans (PAP, (looking for clues, prioritization of identified potential hazard, making improvements to eliminate the risk and follow up, were rated by employees on a scale from 0 to 5. Paired t-test was used to appraise the significant difference between the managers’ mean scores rated by the supervisors and other workers. 77.1% of workers and 64.2% supervisors rated their managers as either “not done at all” or “poorly done”. Workers’ scores for managers PPA had statistically significantly lower ratings (mean=1.09, SEM = 0.22 compared to that of the supervisors rating (mean= 1.55, SEM = 0.32, with t (14 = -1.185, p = 0.784. There is a closed poor performance perception gaps, of managers’ PPA, of the two groups of employees. It can be concluded that safety is not emphasized, by managers of SSI, as overriding priority and this may have contributed to high reported injuries among their workforce. Courses to enhance managements’ understanding for inclusion of safety among the leading priorities becomes necessary. This will reduce work-related risks and promotes occupational safety and health among the group of workers.

  16. Pre- and post-exposure safety and efficacy of attenuated rabies virus vaccines are enhanced by their expression of IFNγ

    Energy Technology Data Exchange (ETDEWEB)

    Barkhouse, Darryll A. [Department of Cancer Biology, 1020 Locust St., Jefferson Alumni Hall, Room 454, Philadelphia, PA 19107 (United States); Center for Neurovirology 1020 Locust St., Jefferson Alumni Hall, Room 454, Philadelphia, PA 19107 (United States); Faber, Milosz [Center for Neurovirology 1020 Locust St., Jefferson Alumni Hall, Room 454, Philadelphia, PA 19107 (United States); Department of Microbiology and Immunology 1020 Locust St., Jefferson Alumni Hall, Room 465, Philadelphia, PA 19107 (United States); Hooper, D. Craig, E-mail: douglas.hooper@jefferson.edu [Department of Cancer Biology, 1020 Locust St., Jefferson Alumni Hall, Room 454, Philadelphia, PA 19107 (United States); Department of Neurological Surgery, 1020 Locust St., Jefferson Alumni Hall, Room 454, Philadelphia, PA 19107 (United States); Center for Neurovirology 1020 Locust St., Jefferson Alumni Hall, Room 454, Philadelphia, PA 19107 (United States)

    2015-01-01

    Consistent with evidence of a strong correlation between interferon gamma (IFNγ) production and rabies virus (RABV) clearance from the CNS, we recently demonstrated that engineering a pathogenic RABV to express IFNγ highly attenuates the virus. Reasoning that IFNγ expression by RABV vaccines would enhance their safety and efficacy, we reverse-engineered two proven vaccine vectors, GAS and GASGAS, to express murine IFNγ. Mortality and morbidity were monitored during suckling mice infection, immunize/challenge experiments and mixed intracranial infections. We demonstrate that GASγ and GASγGAS are significantly attenuated in suckling mice compared to the GASGAS vaccine. GASγ better protects mice from lethal DRV4 RABV infection in both pre- and post-exposure experiments compared to GASGAS. Finally, GASγGAS reduces post-infection neurological sequelae, compared to control, during mixed intracranial infection with DRV4. These data show IFNγ expression by a vaccine vector can enhance its safety while increasing its efficacy as pre- and post-exposure treatment. - Highlights: • IFNγ expression improves attenuated rabies virus safety and immunogenicity. • IFNγ expression is safer and more immunogenic than doubling glycoprotein expression. • Co-infection with IFNγ-expressing RABV prevents wild-type rabies virus lethality. • Vaccine safety and efficacy is additive for IFNγ and double glycoprotein expression.

  17. Consumer Valuations of Beef Steak Food Safety Enhancement in Canada, Japan, Mexico, and the United States

    NARCIS (Netherlands)

    Tonsor, G.T.; Schroeder, T.C.; Pennings, J.M.E.; Mintert, J.

    2009-01-01

    Food safety concerns have had dramatic impacts on food and livestock markets in recent years. We examine consumer preferences for beef steak food safety assurances. We evaluate the extent to which preferences are heterogeneous within and across country-of-residence defined groups and examine the

  18. ENHANCEMENT OF ROAD SAFETY THROUGH MORE EFFECTIVE ROAD AND TRAFFIC MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Tomasz SZCZURASZEK

    2016-07-01

    Full Text Available To make the policy aimed at mitigating the risk of road incidents more effective, Poland should see the introduction of the more efficient road and traffic management. In November 2008 the European Parliament and the European Council published the Directive on "infrastructure safety management" which provides guidance on the procedures for carrying impact assessments of traffic safety, traffic safety audits, safety management on the road network and monitoring traffic safety in Member States. In this article, the authors have proposed a systemic approach to road and traffic management, involving the implementation of consistent procedures that should include regular revisions of roads, eliminating hazardous sites, speed management, as well as the approval and implementation of traffic organization designs.

  19. Inverse Reliability Task: Artificial Neural Networks and Reliability-Based Optimization Approaches

    OpenAIRE

    Lehký, David; Slowik, Ondřej; Novák, Drahomír

    2014-01-01

    Part 7: Genetic Algorithms; International audience; The paper presents two alternative approaches to solve inverse reliability task – to determine the design parameters to achieve desired target reliabilities. The first approach is based on utilization of artificial neural networks and small-sample simulation Latin hypercube sampling. The second approach considers inverse reliability task as reliability-based optimization task using double-loop method and also small-sample simulation. Efficie...

  20. Safety and efficacy of VisuMax® circle patterns for flap creation and enhancement following small incision lenticule extraction.

    Science.gov (United States)

    Chansue, Ekktet; Tanehsakdi, Morakot; Swasdibutra, Sukanda; McAlinden, Colm

    2015-01-01

    The purpose of this case series is to evaluate the safety and efficacy of VisuMax® Circle patterns in eyes that have undergone small incision lenticule extraction, thus creating a flap to perform an enhancement procedure or residual lenticule extraction. This prospective, single center, case study series evaluated the use of a VisuMax® Circle pattern to create a corneal flap following small incision lenticule extraction. Patients were treated and followed at TRSC International LASIK Center (Bangkok, Thailand) for 3 months to assess the efficacy and safety of the procedure. Efficacy was determined by the surgeon's ability to lift the created corneal flap. The study enrolled 28 eyes. Twenty-seven underwent the VisuMax® Circle pattern procedure for refractive enhancement, and one for residual lenticule extraction. In 100 % of cases (28 eyes) the lifting of the flap was possible, as planned. In all cases of refractive enhancement (27 eyes) by laser in situ keratomileusis (LASIK), the exposure of the stromal bed was sufficient for the necessary excimer laser ablation. No eyes lost two or more Snellen lines of corrected distance visual acuity (CDVA) and no procedure or flap-related complications or serious adverse events occurred. This initial case series demonstrates that VisuMax® Circle pattern is efficacious and a suitable method to create a corneal flap for enhancement, following small incision lenticule extraction.

  1. High Energy Density Solid State Li-ion Battery with Enhanced Safety Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop an all solid state Li-ion battery which is capable of delivering high energy density, combined with high safety over a wide operating...

  2. Strategies for enhancing perioperative safety: promoting joy and meaning in the workforce.

    Science.gov (United States)

    Morath, Julianne; Filipp, Rhonda; Cull, Michael

    2014-10-01

    Workforce safety is a precondition of patient safety, and safety from both physical and psychological harm in the workplace is the foundation for an environment in which joy and meaning can exist. Achieving joy and meaning in the workplace allows health care workers to continuously improve the care they provide. This requires an environment in which disrespectful and harmful behaviors are not tolerated or ignored. Health care leaders have an obligation to create workplace cultures that are characterized by respect, transparency, accountability, learning, and quality care. Evidence suggests, however, that health care settings are rife with disrespectful behavior, poor teamwork, and unsafe working conditions. Solutions for addressing workplace safety problems include defining core values, tasking leaders to act as role models, and committing to becoming a high-reliability organization. Copyright © 2014 AORN, Inc. Published by Elsevier Inc. All rights reserved.

  3. Strengthening the evidence-policy interface for patient safety: enhancing global health through hospital partnerships

    National Research Council Canada - National Science Library

    Syed, Shamsuzzoha B; Dadwal, Viva; Storr, Julie; Riley, Pamela; Rutter, Paul; Hightower, Joyce D; Gooden, Rachel; Kelley, Edward; Pittet, Didier

    2013-01-01

    .... In particular, we use the experience of a global hospital partnership programme focused on patient safety in the African Region to explore how hospital partnerships can be instrumental in advancing...

  4. Sequential optimization and reliability assessment based on dimension reduction method for accurate and efficient reliability-based design optimization

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Jong Min; Lee, Byung Chai; Lee, Ik Jin [KAIST, Daejeon (Korea, Republic of)

    2015-04-15

    This study develops an efficient and accurate methodology for reliability-based design optimization (RBDO) by combining the most probable point (MPP)-based dimension reduction method (DRM) to enhance accuracy and the sequential optimization and reliability assessment (SORA) to enhance efficiency. In many researches, first-order reliability method (FORM) has been utilized for RBDO methods due to its efficiency and simplicity. However, it might not be accurate enough for highly nonlinear performance functions. Therefore, the MPP-based DRM is introduced for the accurate reliability assessment in this study. Even though the MPP-based DRM significantly improves the accuracy, additional computations for the moment-based integration are required. It is desirable to reduce the number of reliability analyses in the RBDO process. Since decoupled approaches such as SORA reduce necessary reliability analyses considerably, DRM-based SORA is proposed in this study for accurate and efficient RBDO. Furthermore, convex linearization is introduced to approximate inactive probabilistic constraints to additionally improve the efficiency. The efficiency and accuracy of the proposed method are verified through numerical examples.

  5. The enhanced knowledge translation and exchange framework for road safety: a brief report on its development and potential impacts.

    Science.gov (United States)

    Hinchcliff, Reece; Senserrick, Teresa; Travaglia, Joanne; Greenfield, David; Ivers, Rebecca

    2017-04-01

    Knowledge translation and exchange (KTE) can enable evidence-informed road safety policy and practice by reducing the gap between what is known to be effective and what actually occurs. A quality improvement project, undertaken within a government policy frame, was implemented in 2015 to produce an enhanced KTE framework for road safety (the framework). Information was collected from 35 road safety stakeholders in the UK, the Netherlands, Norway and Sweden. Thirteen KTE facilitators were identified that covered research funding and production, the expertise of knowledge users and dissemination practices. The framework was subsequently developed, which separated facilitators seen as essential for a KTE system, from others perceived as aspirational due to their lesser influence and the considerable time and resources required for their implementation. The framework provides a heuristic device to enable policy agencies to holistically assess and improve current KTE systems for road safety, to encourage evidence-informed policy and practice. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  6. Exploiting globally available safety information on medical devices to enhance EU market surveillance/vigilance - An analysis of available data sources and their systematic and consistent use

    OpenAIRE

    FARAULO FABIO; GRIESINGER CLAUDIUS

    2017-01-01

    Every day regulatory websites worldwide publish an impressive volumeof new data on safety information on related to medical devices, which remains largely unexploited. This report recommends ways towards the effective exploitation of this information for early risk / signal detection, thus enhancing patient safety.

  7. The SHIELD (Safety & Health Improvement: Enhancing Law Enforcement Departments Study: Feasibility and Findings

    Directory of Open Access Journals (Sweden)

    Kerry Stephen Kuehl

    2014-05-01

    Full Text Available This randomized prospective trial aimed to assess the feasibility and efficacy of a team-based worksite health and safety intervention for law enforcement personnel. Four-hundred and eight subjects were enrolled and half were randomized to meet participants met for weekly, peer-led sessions delivered from a scripted team-based health and safety curriculum. Curriculum addressed: exercise, nutrition, stress, sleep, body weight, injury, and other unhealthy lifestyle behaviours such as smoking and heavy alcohol use. Health and safety questionnaires administered before and after the intervention found significant improvements for increased fruit and vegetable consumption, overall healthy eating, increased sleep quantity and sleep quality, and reduced personal stress.

  8. Strengthening the evidence-policy interface for patient safety: enhancing global health through hospital partnerships.

    Science.gov (United States)

    Syed, Shamsuzzoha B; Dadwal, Viva; Storr, Julie; Riley, Pamela; Rutter, Paul; Hightower, Joyce D; Gooden, Rachel; Kelley, Edward; Pittet, Didier

    2013-10-16

    Strengthening the evidence-policy interface is a well-recognized health system challenge in both the developed and developing world. Brokerage inherent in hospital-to-hospital partnerships can boost relationships between "evidence" and "policy" communities and move developing countries towards evidence based patient safety policy. In particular, we use the experience of a global hospital partnership programme focused on patient safety in the African Region to explore how hospital partnerships can be instrumental in advancing responsive decision-making, and the translation of patient safety evidence into health policy and planning. A co-developed approach to evidence-policy strengthening with seven components is described, with reflections from early implementation. This rapidly expanding field of enquiry is ripe for shared learning across continents, in keeping with the principles and spirit of health systems development in a globalized world.

  9. Use of Active-Play Video Games to Enhance Aerobic Fitness in Schizophrenia: Feasibility, Safety, and Adherence.

    Science.gov (United States)

    Kimhy, David; Khan, Samira; Ayanrouh, Lindsey; Chang, Rachel W; Hansen, Marie C; Lister, Amanda; Ballon, Jacob S; Vakhrusheva, Julia; Armstrong, Hilary F; Bartels, Matthew N; Sloan, Richard P

    2016-02-01

    Active-play video games have been used to enhance aerobic fitness in various clinical populations, but their use among individuals with schizophrenia has been limited. Feasibility, acceptability, safety, and adherence data were obtained for use of aerobic exercise (AE) equipment by 16 individuals with schizophrenia during a 12-week AE program consisting of three one-hour exercise sessions per week. Equipment included exercise video games for Xbox 360 with Kinect motion sensing devices and traditional exercise equipment. Most participants (81%) completed the training, attending an average of 79% of sessions. The proportion of time spent playing Xbox (39%) exceeded time spent on any other type of equipment. When using Xbox, participants played 2.24±1.59 games per session and reported high acceptability and enjoyment ratings, with no adverse events. Measures of feasibility, acceptability, adherence, and safety support the integration of active-play video games into AE training for people with schizophrenia.

  10. Efforts toward enhancing seismic safety at Kashiwazaki Kariwa nuclear power station

    Energy Technology Data Exchange (ETDEWEB)

    Yamashita, Kazuhiko

    2010-09-15

    Kashiwazaki-Kariwa Nuclear Power Station, 8212MW, was struck by M6.8 quakes in July 2007. TEPCO has steadily been conducting restoration and post-earthquake equipment integrity assessment, aiming to make it a disaster-resistant power station. 2 units among 7 resumed commercial operation by June 2010. This earthquake has provided a great deal of knowledge and information useful for nuclear safety improvement. It has also served as a valuable reference for the IAEA in developing earthquake-related guidelines. TEPCO would like to share the knowledge and information thereby contributing to improving the safety of nuclear power generation. We will introduce some of our activities.

  11. Interval Estimation of Stress-Strength Reliability Based on Lower Record Values from Inverse Rayleigh Distribution

    Directory of Open Access Journals (Sweden)

    Bahman Tarvirdizade

    2014-01-01

    Full Text Available We consider the estimation of stress-strength reliability based on lower record values when X and Y are independently but not identically inverse Rayleigh distributed random variables. The maximum likelihood, Bayes, and empirical Bayes estimators of R are obtained and their properties are studied. Confidence intervals, exact and approximate, as well as the Bayesian credible sets for R are obtained. A real example is presented in order to illustrate the inferences discussed in the previous sections. A simulation study is conducted to investigate and compare the performance of the intervals presented in this paper and some bootstrap intervals.

  12. Enhancing Nursing Staffing Forecasting With Safety Stock Over Lead Time Modeling.

    Science.gov (United States)

    McNair, Douglas S

    2015-01-01

    In balancing competing priorities, it is essential that nursing staffing provide enough nurses to safely and effectively care for the patients. Mathematical models to predict optimal "safety stocks" have been routine in supply chain management for many years but have up to now not been applied in nursing workforce management. There are various aspects that exhibit similarities between the 2 disciplines, such as an evolving demand forecast according to acuity and the fact that provisioning "stock" to meet demand in a future period has nonzero variable lead time. Under assumptions about the forecasts (eg, the demand process is well fit as an autoregressive process) and about the labor supply process (≥1 shifts' lead time), we show that safety stock over lead time for such systems is effectively equivalent to the corresponding well-studied problem for systems with stationary demand bounds and base stock policies. Hence, we can apply existing models from supply chain analytics to find the optimal safety levels of nurse staffing. We use a case study with real data to demonstrate that there are significant benefits from the inclusion of the forecast process when determining the optimal safety stocks.

  13. Enhanced FAA-Hybrid III dummy for aircraft occupant safety assessment

    NARCIS (Netherlands)

    Waagmeester, C.D.; Ratingen, M.R. van; Giavotto, V.; Notarnicola, L.; Goldner, S.

    2002-01-01

    Following an integral approach unique in aircraft safety, the European HeliSafe project aims to improve the survivability of helicopter crashes and to reduce the risk at injuries for occupants in cockpit and cabin. In the project, a modified FAA-Hybrid III is used for the baseline-, design- and

  14. Can We Learn from Aviation : Safety Enhancements in Transport by Achieving Human Orientated Resilient Shipping Environment

    NARCIS (Netherlands)

    Turan, O.; Kurt, R.E.; Arslan, V.; Silvagni, S.; Ducci, M.; Liston, P.; Schraagen, J.M.; Fang, I.; Papadakis, G.

    2016-01-01

    It is well reported in the literature that more than 80% of shipping accidents are attributed to Human/organisational Error. Maritime community has realised that despite all the increased safety standards and technological developments, accidents are still occurring and the systems are not resilient

  15. Enhancing patient safety with intelligent intravenous infusion devices: experience in a specialty cardiac hospital.

    Science.gov (United States)

    Wood, Jacqueline L; Burnette, Jeremy S

    2012-01-01

    The study objective was to evaluate patient safety, increase nursing satisfaction, and affect economic factors through implementation of intelligent intravenous (IV) infusion devices in a specialty cardiac hospital. Intelligent IV infusion devices have been shown to decrease medication errors associated with inpatient infusions. Intelligent IV infusion device evaluation and drug library creation were conducted by a multidisciplinary team within the hospital. Devices were then implemented into patient care, and the impact was analyzed over a 9-month period. Post-implementation data showed that compliance was approximately 100%. A total of 494 critical catches occurred over the study period, resulting in an estimated annual savings of $7,513,333. End-users became familiar with the new technology and recognized the increase in safety measures and time spent with patients. This evaluation suggests that intelligent IV infusion devices resulted in decreased costs and a safer environment for patients. Copyright © 2012 Elsevier Inc. All rights reserved.

  16. Conceptual studies of construction and safety enhancement of ocean SMART mounted on GBS

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Min-Gil, E-mail: gggggtt@kaist.ac.kr [Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Lee, Kang-Heon, E-mail: welcome@kaist.ac.kr [Division of Ocean Systems Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Kim, Seong Gu, E-mail: skim07@kaist.ac.kr [Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Woo, Il-Guk, E-mail: igwoo@dsme.co.kr [Department of Energy System R and D (Plant R and D), Daewoo Shipbuilding and Marine Engineering Co., Ltd., 221-17, Nonhyun-Dong, Gangnam-Gu, Seoul 135-010 (Korea, Republic of); Han, Jeong-Hoon, E-mail: jhhan1@dsme.co.kr [Department of Energy System R and D (Plant R and D), Daewoo Shipbuilding and Marine Engineering Co., Ltd., 221-17, Nonhyun-Dong, Gangnam-Gu, Seoul 135-010 (Korea, Republic of); Lee, Phill-Seung, E-mail: philseung@kaist.edu [Division of Ocean Systems Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Lee, Jeong Ik, E-mail: jeongiklee@kaist.ac.kr [Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong Yuseong-gu, Daejeon 305-701 (Korea, Republic of)

    2014-10-15

    Highlights: • We suggested the concept of coupling the SMART to the GBS, and we made suggested improvements. • We describe the design concepts and GA of SMART ONPP. • We analyzed seismic feature of SMART ONPP preliminarily. • We suggested the concept of coupling the IPSS to the SMART ONPP, and we made suggested improvements. - Abstract: From the Fukushima accident, protection of NPPs from any imaginable natural disasters became very important. In this study, the authors suggest a new concept of ocean nuclear power plant (ONPP) by using SMART as a reference reactor, which is the most recent Small Modular Reactor (SMR) developed by Korea, to demonstrate that the proposed concept can improve the safety of NPP from earthquake and tsunami. The proposed concept utilizes Gravity Based Structure (GBS), which is a widely spread construction technique of offshore plants. Because, floating type or submerged type NPPs can be easily affected by severe ocean environments such as tsunamis and storms, additional safety features have to be added to the existing land based plant. In contrast, the newly proposed GBS-type ONPP does not require going through significant design modifications due to inherent characteristics of the construction method. The authors have demonstrated this concept can be applied to the large nuclear power plant in the previous work and will expand this concept for SMRs in this paper. The authors discuss the new concept by presenting design parameters, design requirements, and the new total general arrangement. Furthermore, due to the unique configuration of ONPP SMART, innovative passive safety features can be added to the existing SMART design. The performance of proposed concept to resist earthquake as well as newly added passive safety feature will be discussed by presenting simplified analysis results.

  17. Non-Technical Skills (NTS) for Enhancing Patient Safety: Achievements and Future Directions

    OpenAIRE

    Kodate, Naonori; Ross, Anthony; Anderson, Janet E; Flin, R

    2012-01-01

    Problems in team communication and decision making have been implicated in accidents in high risk industries such as aviation, off shore oil processing, nuclear power generation. Recognition of the role that breakdowns in communication and teamwork play in patient safety incidents has led to a plethora of studies in the area of what has come to be widely known as non-technical skills (NTS); a term initially used in European aviation (1). This has led to increasing interest in i...

  18. ENHANCEMENT OF ROAD SAFETY BY IMPROVING THE PROCESS OF ROAD INFRASTRUCTURE DESIGNING

    Directory of Open Access Journals (Sweden)

    Tomasz SZCZURASZEK

    2016-07-01

    Full Text Available Characteristics of road infrastructure affect the level of road safety significantly. Therefore, the process of designing such infrastructure gains special importance. A general concept of improving road infrastructure designs has been formulated based on the analysis of causes of their low quality. The concept includes the following types of measures: educational, procedural, publishing, informative, and legal to be taken by central government authorities. Educational actions are to involve primarily the systematic training for all persons involved in the designing process. Moreover, the introduction of road safety procedures has been proposed for all road infrastructure designs as well as the preparation of study documentation, a new ‘Design Consultation Card’, consulting geometric solutions, and the procedures that should improve the quality of ToRs. Activities within publishing are to focus on preparing and publishing design-related studies. Informative actions include the establishment of a voivodeship road safety database including, among other, design norms and regulations, design standards, catalogues of good and bad practices, manuals, scripts, training materials, examples of ToR, and auxiliary designing materials. The last group of activities requires national regulations.

  19. A sequential-move game for enhancing safety and security cooperation within chemical clusters.

    Science.gov (United States)

    Pavlova, Yulia; Reniers, Genserik

    2011-02-15

    The present paper provides a game theoretic analysis of strategic cooperation on safety and security among chemical companies within a chemical industrial cluster. We suggest a two-stage sequential move game between adjacent chemical plants and the so-called Multi-Plant Council (MPC). The MPC is considered in the game as a leader player who makes the first move, and the individual chemical companies are the followers. The MPC's objective is to achieve full cooperation among players through establishing a subsidy system at minimum expense. The rest of the players rationally react to the subsidies proposed by the MPC and play Nash equilibrium. We show that such a case of conflict between safety and security, and social cooperation, belongs to the 'coordination with assurance' class of games, and we explore the role of cluster governance (fulfilled by the MPC) in achieving a full cooperative outcome in domino effects prevention negotiations. The paper proposes an algorithm that can be used by the MPC to develop the subsidy system. Furthermore, a stepwise plan to improve cross-company safety and security management in a chemical industrial cluster is suggested and an illustrative example is provided. Copyright © 2010 Elsevier B.V. All rights reserved.

  20. The use of information technology to enhance patient safety and nursing efficiency.

    Science.gov (United States)

    Lee, Tso-Ying; Sun, Gi-Tseng; Kou, Li-Tseng; Yeh, Mei-Ling

    2017-10-23

    Issues in patient safety and nursing efficiency have long been of concern. Advancing the role of nursing informatics is seen as the best way to address this. The aim of this study was to determine if the use, outcomes and satisfaction with a nursing information system (NIS) improved patient safety and the quality of nursing care in a hospital in Taiwan. This study adopts a quasi-experimental design. Nurses and patients were surveyed by questionnaire and data retrieval before and after the implementation of NIS in terms of blood drawing, nursing process, drug administration, bar code scanning, shift handover, and information and communication integration. Physiologic values were easier to read and interpret; it took less time to complete electronic records (3.7 vs. 9.1 min); the number of errors in drug administration was reduced (0.08% vs. 0.39%); bar codes reduced the number of errors in blood drawing (0 vs. 10) and transportation of specimens (0 vs. 0.42%); satisfaction with electronic shift handover increased significantly; there was a reduction in nursing turnover (14.9% vs. 16%); patient satisfaction increased significantly (3.46 vs. 3.34). Introduction of NIS improved patient safety and nursing efficiency and increased nurse and patient satisfaction. Medical organizations must continually improve the nursing information system if they are to provide patients with high quality service in a competitive environment.

  1. Surgical innovation-enhanced quality and the processes that assure patient/provider safety: A surgical conundrum.

    Science.gov (United States)

    Bruny, Jennifer; Ziegler, Moritz

    2015-12-01

    Innovation is a crucial part of surgical history that has led to enhancements in the quality of surgical care. This comprises both changes which are incremental and those which are frankly disruptive in nature. There are situations where innovation is absolutely required in order to achieve quality improvement or process improvement. Alternatively, there are innovations that do not necessarily arise from some need, but simply are a new idea that might be better. All change must assure a significant commitment to patient safety and beneficence. Innovation would ideally enhance patient care quality and disease outcomes, as well stimulate and facilitate further innovation. The tensions between innovative advancement and patient safety, risk and reward, and demonstrated effectiveness versus speculative added value have created a contemporary "surgical conundrum" that must be resolved by a delicate balance assuring optimal patient/provider outcomes. This article will explore this delicate balance and the rules that govern it. Recommendations are made to facilitate surgical innovation through clinical research. In addition, we propose options that investigators and institutions may use to address competing priorities. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Pre- and post-exposure safety and efficacy of attenuated rabies virus vaccines are enhanced by their expression of IFNγ.

    Science.gov (United States)

    Barkhouse, Darryll A; Faber, Milosz; Hooper, D Craig

    2015-01-01

    Consistent with evidence of a strong correlation between interferon gamma (IFNγ) production and rabies virus (RABV) clearance from the CNS, we recently demonstrated that engineering a pathogenic RABV to express IFNγ highly attenuates the virus. Reasoning that IFNγ expression by RABV vaccines would enhance their safety and efficacy, we reverse-engineered two proven vaccine vectors, GAS and GASGAS, to express murine IFNγ. Mortality and morbidity were monitored during suckling mice infection, immunize/challenge experiments and mixed intracranial infections. We demonstrate that GASγ and GASγGAS are significantly attenuated in suckling mice compared to the GASGAS vaccine. GASγ better protects mice from lethal DRV4 RABV infection in both pre- and post-exposure experiments compared to GASGAS. Finally, GASγGAS reduces post-infection neurological sequelae, compared to control, during mixed intracranial infection with DRV4. These data show IFNγ expression by a vaccine vector can enhance its safety while increasing its efficacy as pre- and post-exposure treatment. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. First wall and blanket module safety enhancement by material selection and design decision

    Energy Technology Data Exchange (ETDEWEB)

    Merrill, B.J.

    1980-01-01

    A thermal/mechanical study has been performed which illustrates the behavior of a fusion reactor first wall and blanket module during a loss of coolant flow event. The relative safety advantages of various material and design options were determined. A generalized first wall-blanket concept was developed to provide the flexibility to vary the structural material (stainless steel vs titanium), coolant (helium vs water), and breeder material (liquid lithium vs solid lithium aluminate). In addition, independent vs common first wall-blanket cooling and coupled adjacent module cooling design options were included in the study. The comparative analyses were performed using a modified thermal analysis code to handle phase change problems.

  4. Accounting for Proof Test Data in a Reliability Based Design Optimization Framework

    Science.gov (United States)

    Ventor, Gerharad; Scotti, Stephen J.

    2012-01-01

    This paper investigates the use of proof (or acceptance) test data during the reliability based design optimization of structural components. It is assumed that every component will be proof tested and that the component will only enter into service if it passes the proof test. The goal is to reduce the component weight, while maintaining high reliability, by exploiting the proof test results during the design process. The proposed procedure results in the simultaneous design of the structural component and the proof test itself and provides the designer with direct control over the probability of failing the proof test. The procedure is illustrated using two analytical example problems and the results indicate that significant weight savings are possible when exploiting the proof test results during the design process.

  5. Reliability-based optimization of an active vibration controller using evolutionary algorithms

    Science.gov (United States)

    Saraygord Afshari, Sajad; Pourtakdoust, Seid H.

    2017-04-01

    Many modern industrialized systems such as aircrafts, rotating turbines, satellite booms, etc. cannot perform their desired tasks accurately if their uninhibited structural vibrations are not controlled properly. Structural health monitoring and online reliability calculations are emerging new means to handle system imposed uncertainties. As stochastic forcing are unavoidable, in most engineering systems, it is often needed to take them into the account for the control design process. In this research, smart material technology is utilized for structural health monitoring and control in order to keep the system in a reliable performance range. In this regard, a reliability-based cost function is assigned for both controller gain optimization as well as sensor placement. The proposed scheme is implemented and verified for a wing section. Comparison of results for the frequency responses is considered to show potential applicability of the presented technique.

  6. Reliability-Based Design and Planning of Inspection and Monitoring of Offshore Wind Turbines

    DEFF Research Database (Denmark)

    Marquez-Dominguez, Sergio

    Maintaining and developing a sustainable wind industry is the main motivation of this PhD thesis entitled “Reliability-based design and planning of inspection and monitoring of offshore wind turbines”. In this thesis, statistical methods and probability theory are important mathematical tools used...... between the costs of the substructures and the annual wind energy production as well as to maximize the benefits coming from adequate operational control configurations which will increase the material saving in the substructures. The key goal is to decrease the cost of energy (CoE) considering......, at the same time, a suitable life-cycle for the offshore wind turbines, assuring an acceptable risk level. The probabilistic tools relate to and use the expertise developed in the oil and gas industry. The expertise can be applied to the wind industry in order to optimize the structural design with respect...

  7. Cost Optimal Reliability Based Inspection and Replacement Planning of Piping Subjected to CO2 Corrosion

    DEFF Research Database (Denmark)

    Hellevik, S. G.; Langen, I.; Sørensen, John Dalsgaard

    1999-01-01

    A methodology for cost optimal reliability based inspection and replacement planning of piping subjected to CO2 corrosion is described. Both initial (design phase) and in-service planning are dealt with. The methodology is based on the application of methods for structural reliability analysis...... within the framework of Bayesian decision theory. The planning problem is formulated as an optimization problem where the expected lifetime costs are minimized with a constraint on the minimum acceptable reliability level. The optimization parameters are the number of inspections in the expected lifetime......, consistent incorporation and handling of uncertainties, and consistent updating of inspection and replacement plans based on inspection results. The latter is achieved through application of Bayesian statistics for updating in combination with structural reliability methods....

  8. Roadside design in The Netherlands for enhancing safety : contribution to the conference `Traffic safety on Two Continents', Lisbon, Portugal, September 22-24, 1997.

    NARCIS (Netherlands)

    Schoon, C.C.

    1998-01-01

    Safety barriers are often used on motorways. Accident figures, however, show that a safety barrier is involved in approximately 20% of all fatal accidents. This paper considers safety barriers within the context of safe designs for shoulders on motorways. This research is related to the European

  9. Honeycomb-like porous gel polymer electrolyte membrane for lithium ion batteries with enhanced safety

    Science.gov (United States)

    Zhang, Jinqiang; Sun, Bing; Huang, Xiaodan; Chen, Shuangqiang; Wang, Guoxiu

    2014-01-01

    Lithium ion batteries have shown great potential in applications as power sources for electric vehicles and large-scale energy storage. However, the direct uses of flammable organic liquid electrolyte with commercial separator induce serious safety problems including the risk of fire and explosion. Herein, we report the development of poly(vinylidene difluoride-co-hexafluoropropylene) polymer membranes with multi-sized honeycomb-like porous architectures. The as-prepared polymer electrolyte membranes contain porosity as high as 78%, which leads to the high electrolyte uptake of 86.2 wt%. The PVDF-HFP gel polymer electrolyte membranes exhibited a high ionic conductivity of 1.03 mS cm−1 at room temperature, which is much higher than that of commercial polymer membranes. Moreover, the as-obtained gel polymer membranes are also thermally stable up to 350°C and non-combustible in fire (fire-proof). When applied in lithium ion batteries with LiFePO4 as cathode materials, the gel polymer electrolyte demonstrated excellent electrochemical performances. This investigation indicates that PVDF-HFP gel polymer membranes could be potentially applicable for high power lithium ion batteries with the features of high safety, low cost and good performance. PMID:25168687

  10. Honeycomb-like porous gel polymer electrolyte membrane for lithium ion batteries with enhanced safety.

    Science.gov (United States)

    Zhang, Jinqiang; Sun, Bing; Huang, Xiaodan; Chen, Shuangqiang; Wang, Guoxiu

    2014-08-29

    Lithium ion batteries have shown great potential in applications as power sources for electric vehicles and large-scale energy storage. However, the direct uses of flammable organic liquid electrolyte with commercial separator induce serious safety problems including the risk of fire and explosion. Herein, we report the development of poly(vinylidene difluoride-co-hexafluoropropylene) polymer membranes with multi-sized honeycomb-like porous architectures. The as-prepared polymer electrolyte membranes contain porosity as high as 78%, which leads to the high electrolyte uptake of 86.2 wt%. The PVDF-HFP gel polymer electrolyte membranes exhibited a high ionic conductivity of 1.03 mS cm(-1) at room temperature, which is much higher than that of commercial polymer membranes. Moreover, the as-obtained gel polymer membranes are also thermally stable up to 350 °C and non-combustible in fire (fire-proof). When applied in lithium ion batteries with LiFePO4 as cathode materials, the gel polymer electrolyte demonstrated excellent electrochemical performances. This investigation indicates that PVDF-HFP gel polymer membranes could be potentially applicable for high power lithium ion batteries with the features of high safety, low cost and good performance.

  11. Enhancing road traffic safety : a GIS based methodology to identify potential areas of improvement.

    Science.gov (United States)

    2009-01-01

    It is well known that the major goal of the transportation system is to enhance : mobility and crashes are unwanted by-products which have to be minimized : while achieving the primary goal. Although general people value travel time more : than any o...

  12. The Tapioca Bomb: A Demonstration to Enhance Learning about Combustion and Chemical Safety

    Science.gov (United States)

    Keeratichamroen, Wasana; Dechsri, Precharn; Panijpan, Bhinyo; Ruenwongsa, Pintip

    2010-01-01

    In any demonstration to students, producing light and sound usually ensures interest and can enhance understanding and retention of the concepts involved. A guided inquiry (Predict, Observe, Explain: POE) approach was used to involve the students actively in their learning about the explosive combustion of fine flour particles in air in the…

  13. Systematic review of the safety and efficacy of contrast injection via venous catheters for contrast-enhanced computed tomography

    Directory of Open Access Journals (Sweden)

    S.B. Buijs

    Full Text Available Objective: To examine the safety and efficacy of contrast injection through a central venous catheter (CVC for contrast-enhanced computed tomography (CECT. Methods: A systematic literature search was performed using PubMed. Studies were deemed eligible if they reported on the use of CVCs for contrast administration. Selected articles were assessed for their relevance and risk of bias. Articles with low relevance and high risk of bias or both were excluded. Data from included articles was extracted. Results: Seven studies reported on the use of CVCs for contrast administration. Catheter rupture did not occur in any study. The incidence of dislocation ranged from 2.2-15.4%. Quality of scans was described in three studies, with less contrast enhancement of pulmonary arteries and the thoracic aorta in two studies, and average or above average quality in one study. Four other studies used higher flowrates, but did not report quality of scans. Conclusion: Contrast injection via CVCs can be performed safely for CECT when using a strict protocol. Quality of scans depended on multiple factors like flow rate, indication of the scan, and cardiac output of the patient. In each patient, an individual evaluation whether to use the CVC as access for contrast media should be made, while bolus tracking may be mandatory in most cases. Keywords: Central venous catheter, CVC, Contrast, Contrast-enhanced, CT-scan

  14. Amalgamating Oncolytic Viruses to Enhance Their Safety, Consolidate Their Killing Mechanisms, and Accelerate Their Spread

    Science.gov (United States)

    Ayala-Breton, Camilo; Suksanpaisan, Lukkana; Mader, Emily K; Russell, Stephen J; Peng, Kah-Whye

    2013-01-01

    Oncolytic viruses are structurally and biologically diverse, spreading through tumors and killing them by various mechanisms and with different kinetics. Here, we created a hybrid vesicular stomatitis/measles virus (VSV/MV) that harnesses the safety of oncolytic MV, the speed of VSV, and the tumor killing mechanisms of both viruses. Oncolytic MV targets CD46 and kills by forcing infected cells to fuse with uninfected neighbors, but propagates slowly. VSV spreads rapidly, directly lysing tumor cells, but is neurotoxic and loses oncolytic potency when neuroattenuated by conventional approaches. The hybrid VSV/MV lacks neurotoxicity, replicates rapidly with VSV kinetics, and selectively targets CD46 on tumor cells. Its in vivo performance in a myeloma xenograft model was substantially superior to either MV or widely used recombinant oncolytic VSV-M51. PMID:23842448

  15. Amalgamating oncolytic viruses to enhance their safety, consolidate their killing mechanisms, and accelerate their spread.

    Science.gov (United States)

    Ayala-Breton, Camilo; Suksanpaisan, Lukkana; Mader, Emily K; Russell, Stephen J; Peng, Kah-Whye

    2013-10-01

    Oncolytic viruses are structurally and biologically diverse, spreading through tumors and killing them by various mechanisms and with different kinetics. Here, we created a hybrid vesicular stomatitis/measles virus (VSV/MV) that harnesses the safety of oncolytic MV, the speed of VSV, and the tumor killing mechanisms of both viruses. Oncolytic MV targets CD46 and kills by forcing infected cells to fuse with uninfected neighbors, but propagates slowly. VSV spreads rapidly, directly lysing tumor cells, but is neurotoxic and loses oncolytic potency when neuroattenuated by conventional approaches. The hybrid VSV/MV lacks neurotoxicity, replicates rapidly with VSV kinetics, and selectively targets CD46 on tumor cells. Its in vivo performance in a myeloma xenograft model was substantially superior to either MV or widely used recombinant oncolytic VSV-M51.

  16. Use of encapsulated bacteriophages to enhance farm to fork food safety.

    Science.gov (United States)

    Hussain, Malik A; Liu, Huan; Wang, Qi; Zhong, Fang; Guo, Qian; Balamurugan, Sampathkumar

    2017-09-02

    Bacteriophages have been successfully applied to control the growth of pathogens in foods and to reduce the colonization and shedding of pathogens by food animals. They are set to play a dominant role in food safety in the future. However, many food-processing operations and the microenvironments in food animals' guts inactivate phages and reduce their infectivity. Encapsulation technologies have been used successfully to protect phages against extreme environments, and have been shown to preserve their activity and enable their release in targeted environments. A number of encapsulation technologies have shown potential for use with bacteriophages. This review discusses the current state of knowledge about the use of encapsulation technologies with bacteriophages to control pathogens in foods and food animals.

  17. Use of artificial intelligence to enhance the safety of nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Uhrig, R.E.

    1988-01-01

    In the operation of a nuclear power plant, the sheer magnitude of the number of process parameters and systems interactions poses difficulties for the operators, particularly during abnormal or emergency situations. Recovery from an upset situation depends upon the facility with which the available raw data can be converted into and assimilated as meaningful knowledge. Plant personnel are sometimes affected by stress and emotion, which may have varying degrees of influence on their performance. Expert systems can take some of the uncertainty and guesswork out of their decisions by providing expert advice and rapid access to a large information base. Application of artificial intelligence technologies, particularly expert systems, to control room activities in a nuclear power plant has the potential to reduce operator error and improve power plant safety and reliability. 12 refs.

  18. Using practical ergonomic evaluations in the restaurant industry to enhance safety and comfort: a case study.

    Science.gov (United States)

    Gentzler, Marc D; Smither, Janan A

    2012-01-01

    Restaurant employees must deal with loud noise, busy environments, difficult customers, heavy, awkward, sharp, and hot objects, repetitive motions, and stress on various joints, all of which can lead to fatigue, sudden accidents, and longterm musculoskeletal injury. The goal of this case study was to assess the risk of injuries and accidents from conducting various tasks in the restaurant, specifically carrying/lifting, table management, and polishing silverware. The nine participants were servers at a local country club restaurant. Physical workload was measured by a scale of physical exertion. Cognitive workload was assessed, as well as cumulative trauma disorder risk. Overall results show that there is sufficient risk in some of the tasks to warrant concern. Specific results are discussed, as well as recommendations for improved safety.

  19. Offsetting or Enhancing Behavior: An Empirical Analysis of Motorcycle Helmet Safety Legislation.

    Science.gov (United States)

    Lee, Jonathan M

    2015-10-01

    This study uses state-level panel data from a 33-year period to test the hypotheses of offsetting and enhancing behavior with regards to motorcycle helmet legislation. Results presented in this article find no evidence of offsetting behavior and are consistent with the presence of enhancing behavior. State motorcycle helmet laws are estimated to reduce motorcycle crashes by 18.4% to 31.9%. In the absence of any behavioral adaptations among motorcyclists mandatory helmet laws are not expected to have any significant impact on motorcycle crash rates. The estimated motorcycle crash reductions do not appear to be driven by omitted variable bias or nonclassical measurement error in reported crashes. Overall, the results strongly suggest that mandatory helmet laws yield significant changes in motorcycle mobility in the form of reduced risk taking and/or decreased utilization. © 2015 Society for Risk Analysis.

  20. International cooperation for the development of consistent and stable transportation regulations to promote and enhance safety and security

    Energy Technology Data Exchange (ETDEWEB)

    Strosnider, J. [US Nuclear Regulatory Commission, Washington, DC (United States)

    2004-07-01

    International commerce of radioactive materials crosses national boundaries, linking separate regulatory institutions with a common purpose and making it necessary for these institutions to work together in order to achieve common safety goals in a manner that does not place an undue burden on industry and commerce. Widespread and increasing use of radioactive materials across the world has led to increases in the transport of radioactive materials. The demand for consistency in the oversight of international transport has also increased to prevent unnecessary delays and costs associated with incongruent or redundant regulatory requirements by the various countries through which radioactive material is transported. The International Atomic Energy Agency (IAEA) is the authority for international regulation of transportation of radioactive materials responsible for promulgation of regulations and guidance for the establishment of acceptable methods of transportation for the international community. As such, the IAEA is seen as the focal point for consensus building between its Member States to develop consistency in transportation regulations and reviews and to ensure the safe and secure transport of radioactive material. International cooperation is also needed to ensure stability in our regulatory processes. Changes to transportation regulations should be based on an anticipated safety benefit supported by risk information and insights gained from continuing experience, evaluation, and research studies. If we keep safety as the principle basis for regulatory changes, regulatory stability will be enhanced. Finally, as we endeavour to maintain consistency and stability in our international regulations, we must be mindful of the new security challenges that lay before the international community as a result of a changing terrorist environment. Terrorism is a problem of global concern that also requires international cooperation and support, as we look for ways to

  1. Development of Surface Modification Techniques for Enhanced Safety of Light Water Reactors: Recent Progress and Future Direction at THLAB

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Gwang Hyeok; Jeong, Ui Ju; Son, Hong Hyun; Jeun, Gyoo Dong; Kim, Sung Joong [Hanyang University, Daejeon (Korea, Republic of)

    2016-05-15

    They concluded that the CHF enhancement in nanofluid boiling was mainly affected by the surface characteristics of the developed layer. Furthermore, an introduction of surface modification can be utilized to secure the safety of nuclear reactor systems. At many components of the reactor systems, energetic boiling heat transfer occurs, and potential thermal attack to the systems is expected under normal or accident environments. In particular, during a reactor operation, fission energy is deposited in the fuel assemblies in a core. Also, under severe conditions, failure of a reactor vessel may occur by high temperature molten materials. In this article, we introduce the surface modification techniques and recent achievements. After a brief description of each deposition mechanism, an assessment of thermal margin for both the technologies is discussed based on pool boiling experiments conducted at THLAB. Moreover, in the latter part of each chapter, experimental facilities for applied heat transfer tests to consider reactor environments are presented.

  2. Preclinical safety and efficacy studies with an affinity-enhanced epithelial junction opener and PEGylated liposomal doxorubicin

    Directory of Open Access Journals (Sweden)

    Maximilian Richter

    2015-01-01

    Full Text Available A central treatment resistance mechanism in solid tumors is the maintenance of epithelial junctions between malignant cells that prevent drug penetration into the tumor. We have developed a small recombinant protein (JO-1 that triggers the transient opening of intercellular junctions and thus increases the efficacy of monoclonal antibodies and chemotherapeutic drugs without causing toxicity in mouse tumor models. Here, we provide data toward the clinical translation of an affinity-enhanced version of JO-1, which we call JO-4, in combination with PEGylated liposomal doxorubicin (PLD/Doxil for ovarian cancer therapy. We have presented X-ray crystallography data suggesting a structural basis for the higher affinity of JO-4 to DSG2. We also confirmed JO-4 efficacy in a xenograft model with primary ovarian cancer cells showing that JO-4 can salvage Doxil therapy when given at a dose that was threefold lower than the therapeutic dose. Furthermore, we tested the safety of intravenous JO-4 alone and in combination with Doxil in Macaca fascicularis, an adequate animal model for predicting toxicity in humans. Our studies did not show critical JO-4-related toxicity or an increase of Doxil-related side effects. Our efficacy and safety data will help to support an Investigational new drug-filing for a JO-4/Doxil combination treatment.

  3. Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans

    Directory of Open Access Journals (Sweden)

    Wichit Suthammarak

    2016-01-01

    Full Text Available Crude extract from the pericarp of the mangosteen (mangosteen extract [ME] has exhibited several medicinal properties in both animal models and human cell lines. Interestingly, the cytotoxic activities were always observed in nonpolar fraction of the extract whereas the potent antioxidant was often found in polar fraction. Although it has been demonstrated that the polar fraction of ME exhibited the antioxidant activity, the safety of the polar fraction of ME has never been thoroughly investigated in humans. In this study, we investigated the safety of oral administration of the polar fraction of ME in 11 healthy Thai volunteers. During a 24-week period of the study, only minor and tolerable side effects were reported; no serious side effects were documented. Blood chemistry studies also showed no liver damage or kidney dysfunction in all subjects. We also demonstrated antioxidant property of the polar fraction of ME both in vitro and in vivo. Interestingly, oral administration of the polar fraction of ME enhanced the antioxidant capability of red blood cells and decreased oxidative damage to proteins within red blood cells and whole blood.

  4. Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans.

    Science.gov (United States)

    Suthammarak, Wichit; Numpraphrut, Pornpayom; Charoensakdi, Ratiya; Neungton, Neelobol; Tunrungruangtavee, Vachara; Jaisupa, Nattapon; Charoensak, Suwit; Moongkarndi, Primchanien; Muangpaisan, Weerasak

    2016-01-01

    Crude extract from the pericarp of the mangosteen (mangosteen extract [ME]) has exhibited several medicinal properties in both animal models and human cell lines. Interestingly, the cytotoxic activities were always observed in nonpolar fraction of the extract whereas the potent antioxidant was often found in polar fraction. Although it has been demonstrated that the polar fraction of ME exhibited the antioxidant activity, the safety of the polar fraction of ME has never been thoroughly investigated in humans. In this study, we investigated the safety of oral administration of the polar fraction of ME in 11 healthy Thai volunteers. During a 24-week period of the study, only minor and tolerable side effects were reported; no serious side effects were documented. Blood chemistry studies also showed no liver damage or kidney dysfunction in all subjects. We also demonstrated antioxidant property of the polar fraction of ME both in vitro and in vivo. Interestingly, oral administration of the polar fraction of ME enhanced the antioxidant capability of red blood cells and decreased oxidative damage to proteins within red blood cells and whole blood.

  5. An Examination of Temporal Trends in Electricity Reliability Based on Reports from U.S. Electric Utilities

    Energy Technology Data Exchange (ETDEWEB)

    Eto, Joseph H.; LaCommare, Kristina Hamachi; Larsen, Peter; Todd, Annika; Fisher, Emily

    2012-01-06

    Since the 1960s, the U.S. electric power system has experienced a major blackout about once every 10 years. Each has been a vivid reminder of the importance society places on the continuous availability of electricity and has led to calls for changes to enhance reliability. At the root of these calls are judgments about what reliability is worth and how much should be paid to ensure it. In principle, comprehensive information on the actual reliability of the electric power system and on how proposed changes would affect reliability ought to help inform these judgments. Yet, comprehensive, national-scale information on the reliability of the U.S. electric power system is lacking. This report helps to address this information gap by assessing trends in U.S. electricity reliability based on information reported by electric utilities on power interruptions experienced by their customers. Our research augments prior investigations, which focused only on power interruptions originating in the bulk power system, by considering interruptions originating both from the bulk power system and from within local distribution systems. Our research also accounts for differences among utility reliability reporting practices by employing statistical techniques that remove the influence of these differences on the trends that we identify. The research analyzes up to 10 years of electricity reliability information collected from 155 U.S. electric utilities, which together account for roughly 50% of total U.S. electricity sales. The questions analyzed include: 1. Are there trends in reported electricity reliability over time? 2. How are trends in reported electricity reliability affected by the installation or upgrade of an automated outage management system? 3. How are trends in reported electricity reliability affected by the use of IEEE Standard 1366-2003?

  6. eHand-offs: An IBM Lotus Domino application for ensuring patient safety and enhancing resident supervision in hand-off communications.

    Science.gov (United States)

    Chacko, Vinod; Varvarelis, Nicholas; Kemp, David G

    2006-01-01

    Reliable communication of patient information among physicians during shift changes is an important patient safety parameter. The Joint Commission on Accreditation of Healthcare Organizations [JCAHO] recognized the pitfalls in hand off communications by including standardized hand-offs as a National Patient Safety Goals. We are presenting an electronic application called eHand-offs to address this problem in our residency program. Residents can use this application to hand-off patient information during admissions, transfers, and discharges. eHand-offs also functions as a surveillance tool for administrators to track patient hand offs, ensuring added patient safety and enhancing resident supervision and training.

  7. Using swarm intelligence to boost the root cause analysis process and enhance patient safety.

    Science.gov (United States)

    2016-03-01

    In an effort to strengthen patient safety, leadership at the University of Kentucky HealthCare (UKHC) decided to replace its traditional approach to root cause analysis (RCA) with a process based on swarm intelligence, a concept borrowed from other industries. Under this process, when a problem or error is identified, staff quickly hold a swarm--a meeting in which all those involved in the incident or problem quickly evaluate why the issue occurred and identify potential solutions for implementation. A pillar of the swarm concept is a mandate that there be no punishments or finger-pointing during the swarms. The idea is to encourage staff to be forthcoming to achieve effective solutions. Typically, swarms last for one hour and result in action plans designed to correct problems or deficiencies within a specific period of time. The ED was one of the first areas where UKHC applied swarms. For example, hospital administrators note that the approach has been used to address issues involving patient flow, triage protocols, assessments, overcrowding, and boarding. After seven years, incident reporting at UKHC has increased by 52%, and the health system has experienced a 37% decrease in the observed-to-expected mortality ratio.

  8. Automotive Airbag Safety Enhancement Final Report CRADA No. TSB-1165-95

    Energy Technology Data Exchange (ETDEWEB)

    Cutting, Jack [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Durrell, Robert [Quantic Industries, Inc., San Carlos, CA (United States)

    2017-11-09

    The Vehicle Safety systems (VSS) Division of Quantic Industries, Inc. (QII) manufactured automotive airbag components. When both the driver and the passenger side airbags inflated in a tightly sealed passenger compartment, the compression of the surrounding air could and, in some instances, would cause damage to the eardrums of the occupants. The Aerospace and Division (ADD) of QII had partially developed the technology to fracture the canopy of a jet aircraft at the time of pilot ejection. The technical problem was how to adapt the canopy fracturing technology to the rear window of a motor vehicle in a safe and cost effective manner. The existing approach was to replace the embedded rear window defroster with a series-parallel network of exploding bridge wires (EBWs). This would still provide the defrost function at low voltage/ current, but would cause fracturing of the window when a high current/voltage pulse was applied without pyrotechnics or explosives. The elements of this system were the embedded EBW network and a trunk-mounted fireset. The fireset would store the required energy to fire the network upon the receipt of a trigger signal from the existing air bag crash sensor.

  9. Listeria monocytogenes mutants defective in gallbladder replication represent safety-enhanced vaccine delivery platforms.

    Science.gov (United States)

    Dowd, Georgina C; Bahey-El-Din, Mohammed; Casey, Pat G; Joyce, Susan A; Hill, Colin; Gahan, Cormac G M

    2016-08-02

    The Gram positive intracellular pathogen Listeria monocytogenes represents a promising vaccine or therapeutic DNA delivery vector that has been successfully administered to humans in clinical trials. However in generating Listeria mutants with therapeutic potential it is important to balance safety attenuation with efficacy. Here we show that L. monocytogenes mutants with a reduced capacity for murine gallbladder replication are capable of stimulating T cell responses in mice and protecting vaccinated animals from secondary challenge. Mutation of L. monocytogenes genes lmo2566 or lmo0598 resulted in significant attenuation in the murine model yet mutants retained a capacity for intracellular growth and stimulation of T cell responses against key Listeria epitopes (LLO91-99 and P60217-225). Importantly the mutants showed a reduced capacity for growth in the gallbladders of vaccinated mice as well as significantly reduced faecal shedding indicating that this approach generates live Listeria-based vector delivery systems with a reduced capacity for the spread of live genetically modified microorganisms into the natural environment.

  10. An Enhanced OFDM Resource Allocation Algorithm in C-RAN Based 5G Public Safety Network

    Directory of Open Access Journals (Sweden)

    Lei Feng

    2016-01-01

    Full Text Available Public Safety Network (PSN is the network for critical communication when disaster occurs. As a key technology in 5G, Cloud-Radio Access Network (C-RAN can play an important role in PSN instead of LTE-based RAN. This paper firstly introduces C-RAN based PSN architecture and models the OFDM resource allocation problem in C-RAN based PSN as an integer quadratic programming, which allows the trade-off between expected bitrates and allocating fairness of PSN Service User (PSU. However, C-RAN based PSN needs to improve the efficiency of allocating algorithm because of a mass of PSU-RRH associations when disaster occurs. To deal with it, the resources allocating problem with integer variables is relaxed into one with continuous variables in the first step and an algorithm based on Generalized Bender’s Decomposition (GBD is proposed to solve it. Then we use Feasible Pump (FP method to get a feasible integer solution on the original OFDM resources allocation problem. The final experiments show the total throughput achieved by C-RAN based PSN is at most higher by 19.17% than the LTE-based one. And the average computational time of the proposed GBD and FP algorithm is at most lower than Barrier by 51.5% and GBD with no relaxation by 30.1%, respectively.

  11. The evaluation and enhancement of quality, environmental protection and seaport safety by using FAHP

    Science.gov (United States)

    Tadic, Danijela; Aleksic, Aleksandar; Popovic, Pavle; Arsovski, Slavko; Castelli, Ana; Joksimovic, Danijela; Stefanovic, Miladin

    2017-02-01

    The evaluation and enhancement of business processes in any organization in an uncertain environment presents one of the main requirements of ISO 9000:2008 and has a key effect on competitive advantage and long-term sustainability. The aim of this paper can be defined as the identification and discussion of some of the most important business processes of seaports and the performances of business processes and their key performance indicators (KPIs). The complexity and importance of the treated problem call for analytic methods rather than intuitive decisions. The existing decision variables of the considered problem are described by linguistic expressions which are modelled by triangular fuzzy numbers (TFNs). In this paper, the modified fuzzy extended analytic hierarchy process (FAHP) is proposed. The assessment of the relative importance of each pair of performances and their key performance indicators are stated as a fuzzy group decision-making problem. By using the modified fuzzy extended analytic hierarchy process, the fuzzy rank of business processes of a seaport is obtained. The model is tested through an illustrative example with real-life data, where the obtained data suggest measures which should enhance business strategy and improve key performance indicators. The future improvement is based on benchmark and knowledge sharing.

  12. Obstructive sleep apnea: strategies for minimizing liability and enhancing patient safety.

    Science.gov (United States)

    Svider, Peter F; Pashkova, Anna A; Folbe, Adam J; Eloy, Jean Daniel; Setzen, Michael; Baredes, Soly; Eloy, Jean Anderson

    2013-12-01

    To characterize malpractice litigation regarding obstructive sleep apnea (OSA) and educate physicians on frequently cited factors. Analysis of the Westlaw legal database. Jury verdict and settlement reports were examined for outcome, awards, patient demographic factors, defendant specialty, and alleged causes of malpractice. Out of 54 identified cases, 33 (61.1%) cases were resolved in favor of defendants, 12 (22.2%) via settlement, and 9 (16.7%) through jury award. Median settlement and jury awards did not significantly differ ($750,000 vs $550,000, P > .50). Age and gender did not affect outcome. Otolaryngologists and anesthesiologists were the most frequently named defendants. Forty-seven cases (87.1%) stemmed from OSA patients who underwent procedures with resultant perioperative adverse events. Common alleged factors included death (48.1%), permanent deficits (42.6%), intraoperative complications (35.2%), requiring additional surgery (25.9%), anoxic brain injury (24.1%), inadequate informed consent (24.1%), inappropriate medication administration (22.2%), and inadequate monitoring (20.4%). Litigation related to OSA is frequently associated with perioperative complications more than nonoperative issues such as a failure to diagnose this disorder. Nonetheless, OSA is considerably underdiagnosed, and special attention should be paid to at-risk patients, including close monitoring of their clinical status and the medications they receive. For patients with diagnosed or suspected OSA with planned operative intervention, whether for OSA or an unrelated issue, a comprehensive informed consent process detailing the factors outlined in this analysis is an effective strategy to increase communication and improve the physician-patient relationship, minimize liability, and ultimately improve patient safety.

  13. Electrostatic application of antimicrobial sprays to sanitize food handling and processing surfaces for enhanced food safety

    Energy Technology Data Exchange (ETDEWEB)

    Lyons, Shawn M; Harrison, Mark A [Food Science and Technology Department, University of Georgia, Athens, GA, 30602-2610 (United States); Law, S Edward, E-mail: edlaw@engr.uga.edu [Biological and Agricultural Engineering Department, Applied Electrostatics Laboratory www.ael.engr.uga.edu, University of Georgia, Athens, GA, 30602-4435 (United States)

    2011-06-23

    Human illnesses and deaths caused by foodborne pathogens (e.g., Salmonella enterica, Listeria monocytogenes, Escherichia coli O157:H7, etc.) are of increasing concern globally in maintaining safe food supplies. At various stages of the food production, processing and supply chain antimicrobial agents are required to sanitize contact surfaces. Additionally, during outbreaks of contagious pathogenic microorganisms (e.g., H1N1 influenza), public health requires timely decontamination of extensive surfaces within public schools, mass transit systems, etc. Prior publications verify effectiveness of air-assisted, induction-charged (AAIC) electrostatic spraying of various chemical and biological agents to protect on-farm production of food crops...typically doubling droplet deposition efficiency with concomitant increases in biological control efficacy. Within a biosafety facility this present work evaluated the AAIC electrostatic-spraying process for application of antimicrobial liquids onto various pathogen-inoculated food processing and handling surfaces as a food safety intervention strategy. Fluoroanalysis of AAIC electrostatic sprays (-7.2 mC/kg charge-to-mass ratio) showed significantly greater (p<0.05) mass of tracer active ingredient (A.I.) deposited onto target surfaces at various orientations as compared both to a similar uncharged spray nozzle (0 mC/kg) and to a conventional hydraulic-atomizing nozzle. Per unit mass of A.I. dispensed toward targets, for example, A.I. mass deposited by AAIC electrostatic sprays onto difficult to coat backsides was 6.1-times greater than for similar uncharged sprays and 29.0-times greater than for conventional hydraulic-nozzle sprays. Even at the 56% reduction in peracetic acid sanitizer A.I. dispensed by AAIC electrostatic spray applications, they achieved equal or greater CFU population reductions of Salmonella on most target orientations and materials as compared to uncharged sprays and conventional full-rate hydraulic

  14. Electrostatic application of antimicrobial sprays to sanitize food handling and processing surfaces for enhanced food safety

    Science.gov (United States)

    Lyons, Shawn M.; Harrison, Mark A.; Law, S. Edward

    2011-06-01

    Human illnesses and deaths caused by foodborne pathogens (e.g., Salmonella enterica, Listeria monocytogenes, Escherichia coli O157:H7, etc.) are of increasing concern globally in maintaining safe food supplies. At various stages of the food production, processing and supply chain antimicrobial agents are required to sanitize contact surfaces. Additionally, during outbreaks of contagious pathogenic microorganisms (e.g., H1N1 influenza), public health requires timely decontamination of extensive surfaces within public schools, mass transit systems, etc. Prior publications verify effectiveness of air-assisted, induction-charged (AAIC) electrostatic spraying of various chemical and biological agents to protect on-farm production of food crops...typically doubling droplet deposition efficiency with concomitant increases in biological control efficacy. Within a biosafety facility this present work evaluated the AAIC electrostatic-spraying process for application of antimicrobial liquids onto various pathogen-inoculated food processing and handling surfaces as a food safety intervention strategy. Fluoroanalysis of AAIC electrostatic sprays (-7.2 mC/kg charge-to-mass ratio) showed significantly greater (p<0.05) mass of tracer active ingredient (A.I.) deposited onto target surfaces at various orientations as compared both to a similar uncharged spray nozzle (0 mC/kg) and to a conventional hydraulic-atomizing nozzle. Per unit mass of A.I. dispensed toward targets, for example, A.I. mass deposited by AAIC electrostatic sprays onto difficult to coat backsides was 6.1-times greater than for similar uncharged sprays and 29.0-times greater than for conventional hydraulic-nozzle sprays. Even at the 56% reduction in peracetic acid sanitizer A.I. dispensed by AAIC electrostatic spray applications, they achieved equal or greater CFU population reductions of Salmonella on most target orientations and materials as compared to uncharged sprays and conventional full-rate hydraulic

  15. Seismic-Reliability-Based Optimal Layout of a Water Distribution Network

    Directory of Open Access Journals (Sweden)

    Do Guen Yoo

    2016-02-01

    Full Text Available We proposed an economic, cost-constrained optimal design of a water distribution system (WDS that maximizes seismic reliability while satisfying pressure constraints. The model quantifies the seismic reliability of a WDS through a series of procedures: stochastic earthquake generation, seismic intensity attenuation, determination of the pipe failure status (normal, leakage, and breakage, pipe failure modeling in hydraulic simulation, and negative pressure treatment. The network’s seismic reliability is defined as the ratio of the available quantity of water to the required water demand under stochastic earthquakes. The proposed model allows no pipe option in decisions, making it possible to identify seismic-reliability-based optimal layout for a WDS. The model takes into account the physical impact of earthquake events on the WDS, which ultimately affects the network’s boundary conditions (e.g., failure level of pipes. A well-known benchmark network, the Anytown network, is used to demonstrate the proposed model. The network’s optimal topology and pipe layouts are determined from a series of optimizations. The results show that installing large redundant pipes degrades the system’s seismic reliability because the pipes will cause a large rupture opening under failure. Our model is a useful tool to find the optimal pipe layout that maximizes system reliability under earthquakes.

  16. Improved Reliability-Based Optimization with Support Vector Machines and Its Application in Aircraft Wing Design

    Directory of Open Access Journals (Sweden)

    Yu Wang

    2015-01-01

    Full Text Available A new reliability-based design optimization (RBDO method based on support vector machines (SVM and the Most Probable Point (MPP is proposed in this work. SVM is used to create a surrogate model of the limit-state function at the MPP with the gradient information in the reliability analysis. This guarantees that the surrogate model not only passes through the MPP but also is tangent to the limit-state function at the MPP. Then, importance sampling (IS is used to calculate the probability of failure based on the surrogate model. This treatment significantly improves the accuracy of reliability analysis. For RBDO, the Sequential Optimization and Reliability Assessment (SORA is employed as well, which decouples deterministic optimization from the reliability analysis. The improved SVM-based reliability analysis is used to amend the error from linear approximation for limit-state function in SORA. A mathematical example and a simplified aircraft wing design demonstrate that the improved SVM-based reliability analysis is more accurate than FORM and needs less training points than the Monte Carlo simulation and that the proposed optimization strategy is efficient.

  17. Reliability based impact localization in composite panels using Bayesian updating and the Kalman filter

    Science.gov (United States)

    Morse, Llewellyn; Sharif Khodaei, Zahra; Aliabadi, M. H.

    2018-01-01

    In this work, a reliability based impact detection strategy for a sensorized composite structure is proposed. Impacts are localized using Artificial Neural Networks (ANNs) with recorded guided waves due to impacts used as inputs. To account for variability in the recorded data under operational conditions, Bayesian updating and Kalman filter techniques are applied to improve the reliability of the detection algorithm. The possibility of having one or more faulty sensors is considered, and a decision fusion algorithm based on sub-networks of sensors is proposed to improve the application of the methodology to real structures. A strategy for reliably categorizing impacts into high energy impacts, which are probable to cause damage in the structure (true impacts), and low energy non-damaging impacts (false impacts), has also been proposed to reduce the false alarm rate. The proposed strategy involves employing classification ANNs with different features extracted from captured signals used as inputs. The proposed methodologies are validated by experimental results on a quasi-isotropic composite coupon impacted with a range of impact energies.

  18. Dengue vaccine safety signal: Immune enhancement, waning immunity, or chance occurrence?

    Science.gov (United States)

    Gessner, Bradford D; Halsey, Neal

    2017-06-14

    A new dengue vaccine was associated with increased risk of hospitalized virologically-confirmed disease during year 3 of follow-up among children age 2-5years. Among hypotheses to explain this finding, we could not distinguish definitively between antibody dependent enhancement, waning immunity, or chance occurrence. However, any theory must account for the following: (a) the signal occurred mainly because of decreased dengue among controls rather than increased dengue among vaccinees; (b) among 48 data points, a statistically significant increase in hospitalization among vaccinated children occurred for only one age group, during one year, and in one region; (c) cumulative risk was similar for vaccinated vs. control children age 2-5years at the end of year 5 and lower for vaccinated vs. control children among older age groups; (d) the protective effect of vaccine against hospitalization decreased from years 1-2 to years 3-5 of follow-up for all age groups and regions. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  19. Personalized medicine in human space flight: using Omics based analyses to develop individualized countermeasures that enhance astronaut safety and performance.

    Science.gov (United States)

    Schmidt, Michael A; Goodwin, Thomas J

    2013-01-01

    Space flight is one of the most extreme conditions encountered by humans. Advances in Omics methodologies (genomics, transcriptomics, proteomics, and metabolomics) have revealed that unique differences exist between individuals. These differences can be amplified in extreme conditions, such as space flight. A better understanding of individual differences may allow us to develop personalized countermeasure packages that optimize the safety and performance of each astronaut. In this review, we explore the role of "Omics" in advancing our ability to: (1) more thoroughly describe the biological response of humans in space; (2) describe molecular attributes of individual astronauts that alter the risk profile prior to entering the space environment; (3) deploy Omics techniques in the development of personalized countermeasures; and (4) develop a comprehensive Omics-based assessment and countermeasure platform that will guide human space flight in the future. In this review, we advance the concept of personalized medicine in human space flight, with the goal of enhancing astronaut safety and performance. Because the field is vast, we explore selected examples where biochemical individuality might significantly impact countermeasure development. These include gene and small molecule variants associated with: (1) metabolism of therapeutic drugs used in space; (2) one carbon metabolism and DNA stability; (3) iron metabolism, oxidative stress and damage, and DNA stability; and (4) essential input (Mg and Zn) effects on DNA repair. From these examples, we advance the case that widespread Omics profiling should serve as the foundation for aerospace medicine and research, explore methodological considerations to advance the field, and suggest why personalized medicine may become the standard of care for humans in space.

  20. 48{sup th} Annual meeting on nuclear technology (AMNT 2017). Key topic / Enhanced safety and operation excellence. Focus session: International operational experience

    Energy Technology Data Exchange (ETDEWEB)

    Mohrbach, Ludger [VGB PowerTech e.V., Essen (Germany). Abteilung ' ' N' ' ; Gottschling, Helge

    2017-11-15

    Summary report on the Key Topic Enhanced Safety and Operation Excellence: Focus Session: International Operational Experience and the Nuclear Energy Campus of the 48{sup th} Annual Meeting on Nuclear Technology (AMNT 2017) held in Berlin, 16 to 17 May 2017.

  1. 47{sup th} Annual conference on nuclear technology (AMNT 2016). Key topics / Outstanding know-how and sustainable innovations - enhanced safety and operation excellence

    Energy Technology Data Exchange (ETDEWEB)

    Raetzke, Christian [CONLAR - Consulting on Nuclear Law, Licensing and Regulation, Leipzig (Germany); Fischer, Erwin [PreussenElektra GmbH, Hannover (Germany). Management Board; Mohrbach, Ludger [VGB PowerTech e.V., Essen (Germany). Competence Center ' ' Nuclear Power Plants' '

    2016-08-15

    Summary report on the Key Topics ''Outstanding Know-How and Sustainable Innovations'' and ''Enhanced Safety and Operation Excellence'' of the 47{sup th} Annual Conference on Nuclear Technology (AMNT 2016) held in Hamburg, 10 to 12 May 2016. Other Sessions of AMNT 2016 will be covered in further issues of atw.

  2. Perceptual attraction in tool use: evidence for a reliability-based weighting mechanism.

    Science.gov (United States)

    Debats, Nienke B; Ernst, Marc O; Heuer, Herbert

    2017-04-01

    Humans are well able to operate tools whereby their hand movement is linked, via a kinematic transformation, to a spatially distant object moving in a separate plane of motion. An everyday example is controlling a cursor on a computer monitor. Despite these separate reference frames, the perceived positions of the hand and the object were found to be biased toward each other. We propose that this perceptual attraction is based on the principles by which the brain integrates redundant sensory information of single objects or events, known as optimal multisensory integration. That is, 1) sensory information about the hand and the tool are weighted according to their relative reliability (i.e., inverse variances), and 2) the unisensory reliabilities sum up in the integrated estimate. We assessed whether perceptual attraction is consistent with optimal multisensory integration model predictions. We used a cursor-control tool-use task in which we manipulated the relative reliability of the unisensory hand and cursor position estimates. The perceptual biases shifted according to these relative reliabilities, with an additional bias due to contextual factors that were present in experiment 1 but not in experiment 2 The biased position judgments' variances were, however, systematically larger than the predicted optimal variances. Our findings suggest that the perceptual attraction in tool use results from a reliability-based weighting mechanism similar to optimal multisensory integration, but that certain boundary conditions for optimality might not be satisfied.NEW & NOTEWORTHY Kinematic tool use is associated with a perceptual attraction between the spatially separated hand and the effective part of the tool. We provide a formal account for this phenomenon, thereby showing that the process behind it is similar to optimal integration of sensory information relating to single objects. Copyright © 2017 the American Physiological Society.

  3. Reliability-Based Planning of Inspection, Operation and Maintenance for Offshore Oil & Gas Structures and Wind Turbines

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard

    2011-01-01

    Reliability-based cost-optimal planning of inspection, maintenance and operation has many applications. In this paper applications for planning of inspections for oil & gas jacket structures and of operation and maintenance of offshore wind turbines are described and illustrated by examples....

  4. Sailing a safe ship: improving patient safety by enhancing the leadership skills of new consultant specialist surgeons.

    Science.gov (United States)

    Shah, Peter; Cross, Vinette; Sii, Freda

    2013-01-01

    The potential for "discontinuities in care" arising from the turbulent transition from specialist trainee to consultant specialist presents risks to patient safety. But it is easy to lose sight of the affective needs of individuals facing the burden of keeping patients safe. This article describes a 2-day program focused on new and prospective consultant specialist ophthalmic surgeons entitled "Sailing a Safe Ship" (SASS). The purpose was to facilitate understanding and analysis of their personal holistic learning needs and enhance individual agency in optimizing learning during the transition period. The program used gaming, team challenges, meta-planning, role play and professional actors, interactive presentations, and self-analysis tools to portray the real world of consultant specialist practice in terms of ill-defined problems requiring "elite communication" and effective negotiation of value differences and priorities for their resolution. Participants' insights into their individual learning were recorded in scheduled reflective sessions. The immediate impact on their learning was also considered in terms of direct (instructional) and indirect (nurturant) effects. Participants' insights reflected 4 key themes: admitting vulnerability and uncertainty, taking responsibility for managing risk, being self-aware and reflexive, and internalizing authentic leadership. Four instructional and 4 nurturant effects were revealed. Preliminary findings on long-term impact on participants' practice are outlined. Evidence from the evaluation indicated that participants felt empowered to construct a personal strategic response to unfamiliar and unanticipated workplace demands and pressures, adopt a capability mindset that would accelerate their capacity to fulfill an enhanced leadership role, and take a holistic approach to their continuing self-directed development as leaders and educators. Copyright © 2013 The Alliance for Continuing Education in the Health Professions

  5. 49 CFR Appendix E to Part 238 - General Principles of Reliability-Based Maintenance Programs

    Science.gov (United States)

    2010-10-01

    ... altered only by basic changes in the design. Safety consequences can, in nearly all cases, be reduced to... that a failure has occurred); (3) The visibility of reduced resistance to failure (evidence that a..., the operating organization must be prepared to collect and respond to real data throughout the...

  6. The Neuroergonomics of Aircraft Cockpits: The Four Stages of Eye-Tracking Integration to Enhance Flight Safety

    Directory of Open Access Journals (Sweden)

    Vsevolod Peysakhovich

    2018-02-01

    Full Text Available Commercial aviation is currently one of the safest modes of transportation; however, human error is still one major contributing cause of aeronautical accidents and incidents. One promising avenue to further enhance flight safety is Neuroergonomics, an approach at the intersection of neuroscience, cognitive engineering and human factors, which aims to create better human–system interaction. Eye-tracking technology allows users to “monitor the monitoring” by providing insights into both pilots’ attentional distribution and underlying decisional processes. In this position paper, we identify and define a framework of four stages of step-by-step integration of eye-tracking systems in modern cockpits. Stage I concerns Pilot Training and Flight Performance Analysis on-ground; stage II proposes On-board Gaze Recordings as extra data for the “black box” recorders; stage III describes Gaze-Based Flight Deck Adaptation including warning and alerting systems, and, eventually, stage IV prophesies Gaze-Based Aircraft Adaptation including authority taking by the aircraft. We illustrate the potential of these four steps with a description of incidents or accidents that we could certainly have avoided thanks to eye-tracking. Estimated milestones for the integration of each stage are also proposed together with a list of some implementation limitations. We believe that the research institutions and industrial actors of the domain will all benefit from the integration of the framework of the eye-tracking systems into cockpits.

  7. Ablative safety margin depicted by fusion imaging with post-treatment contrast-enhanced ultrasound and pre-treatment CECT/CEMRI after radiofrequency ablation for liver cancers.

    Science.gov (United States)

    Bo, Xiao-Wan; Xu, Hui-Xiong; Guo, Le-Hang; Sun, Li-Ping; Li, Xiao-Long; Zhao, Chong-Ke; He, Ya-Ping; Liu, Bo-Ji; Li, Dan-Dan; Zhang, Kun; Wang, Dan

    2017-10-01

    To evaluate the value of fusion imaging with post-treatment contrast-enhanced ultrasound (CEUS) and pre-treatment contrast-enhanced CT/MRI (CECT/CEMRI) in evaluating ablative safety margin after percutaneous ultrasound (US)-guided radiofrequency ablation (RFA) for liver cancers. 34 consecutive patients with 47 liver lesions who had undergone RFA were included. Fusion imaging with post-treatment CEUS and pre-treatment CECT/CEMRI was carried out to evaluate local treatment response and ablative safety margin within 1-3 days after RFA. The minimal ablative safety margins of the ablation zones were recorded. The complete response (CR) rate was calculated with reference to CECT/CEMRI results 1 month after RFA. The local tumour progression (LTP) was also recorded. Of the 47 ablation zones, 47 (100%) were clearly depicted with CEUS-CECT/CEMRI fusion imaging, 36 (76.6%) with US-CECT/CEMRI fusion imaging and 21 (44.7%) with conventional US (both p ablative safety margins were great than or equal to 5 mm in 28 ablation zones, between 0 and 5 mm in 15, and less than 0 mm in 4. For the four lesions without enough ablative safety margin, three were referred to follow-up because CEUS showed larger ablation zones than pre-treatment lesions and the remaining lesion was subject to additional RFA 5 days after the first RFA. The CR rate was 95.7% (45/47) with reference to CECT/CEMRI results 1 month after RFA. During 2 to 34 months follow-up, LTP was found in two (4.4%) of 45 lesions with CR. Insufficient ablative safety margin was more commonly found in those lesions with LTP than those without LTP (1/4 vs 1/43, p ablative safety margin accurately after RFA. Inadequate ablative safety margin is associated with LTP. Depiction of ablative safety margin by fusion imaging after ablation might be considered as a routine procedure to assess the treatment response of RFA. Advances in knowledge: Fusion imaging with post-treatment CEUS and pre-treatment CECT/CEMRI is an effective method to

  8. Strengthening leadership as a catalyst for enhanced patient safety culture: a repeated cross-sectional experimental study.

    Science.gov (United States)

    Kristensen, Solvejg; Christensen, Karl Bang; Jaquet, Annette; Møller Beck, Carsten; Sabroe, Svend; Bartels, Paul; Mainz, Jan

    2016-05-13

    Current literature emphasises that clinical leaders are in a position to enable a culture of safety, and that the safety culture is a performance mediator with the potential to influence patient outcomes. This paper aims to investigate staff's perceptions of patient safety culture in a Danish psychiatric department before and after a leadership intervention. A repeated cross-sectional experimental study by design was applied. In 2 surveys, healthcare staff were asked about their perceptions of the patient safety culture using the 7 patient safety culture dimensions in the Safety Attitudes Questionnaire. To broaden knowledge and strengthen leadership skills, a multicomponent programme consisting of academic input, exercises, reflections and discussions, networking, and action learning was implemented among the clinical area level leaders. In total, 358 and 325 staff members participated before and after the intervention, respectively. 19 of the staff members were clinical area level leaders. In both surveys, the response rate was >75%. The proportion of frontline staff with positive attitudes improved by ≥5% for 5 of the 7 patient safety culture dimensions over time. 6 patient safety culture dimensions became more positive (increase in mean) (pleadership can act as a significant catalyst for patient safety culture improvement. Further studies using a longitudinal study design are recommended to investigate the mechanism behind leadership's influence on patient safety culture, sustainability of improvements over time, and the association of change in the patient safety culture measures with change in psychiatric patient safety outcomes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  9. Safety, feasibility, and tolerance of early oral feeding after colorectal resection outside an enhanced recovery after surgery (ERAS) program.

    Science.gov (United States)

    Gianotti, Luca; Nespoli, Luca; Torselli, Laura; Panelli, Mariarita; Nespoli, Angelo

    2011-06-01

    It is generally believed that resumption of feeding after colorectal resection is indicated only after recovery of bowel function. This study was designed to verify safety, feasibility, and tolerance of early oral postoperative feeding (EOF) outside an enhanced recovery after surgery (ERAS) program. One hundred patient candidates to elective colorectal resection were prospectively enrolled in an EOF program. Feeding was started on postoperative day (POD) 1 with oral nutritional supplement (ONS). On POD 2, patients had normal food plus ONS to reach 1,000-1,200 kcal/day with progressive increase until 1,800-2,000 kcal/day. Results were compared with historical controls (n = 100) in whom oral feeding was allowed only after full bowel function recovery. The ERAS program was not applied in both groups. The EOF group had a better recovery of short half-life protein synthesis compared with the control group (P days (range, 1-6 days) in the EOF group versus 5 days (range, 2-8 days) in the control group (P = 0.001). The feeding protocol was completed in 89 patients within POD 5. Tolerance to resumption of feeding was similar in the two groups. The overall rate of postoperative complication was 22% in the EOF group vs. 27% in the control group (P = 0.51). The median length of hospitalization was 9 days (range, 6-25 days) in the EOF group vs. 12 days (range, 6-31 days) in controls (P = 0.01). EOF after colorectal operations is feasible and safe outside an ERAS program.

  10. African fermented dairy products - Overview of predominant technologically important microorganisms focusing on African Streptococcus infantarius variants and potential future applications for enhanced food safety and security.

    Science.gov (United States)

    Jans, Christoph; Meile, Leo; Kaindi, Dasel Wambua Mulwa; Kogi-Makau, Wambui; Lamuka, Peter; Renault, Pierre; Kreikemeyer, Bernd; Lacroix, Christophe; Hattendorf, Jan; Zinsstag, Jakob; Schelling, Esther; Fokou, Gilbert; Bonfoh, Bassirou

    2017-06-05

    Milk is a major source of nutrients, but can also be a vehicle for zoonotic foodborne diseases, especially when raw milk is consumed. In Africa, poor processing and storage conditions contribute to contamination, outgrowth and transmission of pathogens, which lead to spoilage, reduced food safety and security. Fermentation helps mitigate the impact of poor handling and storage conditions by enhancing shelf life and food safety. Traditionally-fermented sour milk products are culturally accepted and widely distributed in Africa, and rely on product-specific microbiota responsible for aroma, flavor and texture. Knowledge of microbiota and predominant, technologically important microorganisms is critical in developing products with enhanced quality and safety, as well as sustainable interventions for these products, including Africa-specific starter culture development. This narrative review summarizes current knowledge of technologically-important microorganisms of African fermented dairy products (FDP) and raw milk, taking into consideration novel findings and taxonomy when re-analyzing data of 29 publications covering 25 products from 17 African countries. Technologically-important lactic acid bacteria such as Lactococcus lactis and Streptococcus infantarius subsp. infantarius (Sii), Lactobacillus spp. and yeasts predominated in raw milk and FDP across Africa. Re-analysis of data also suggests a much wider distribution of Sii and thus a potentially longer history of use than previously expected. Therefore, evaluating the role and safety of African Sii lineages is important when developing interventions and starter cultures for FDP in Africa to enhance food safety and food security. In-depth functional genomics, epidemiologic investigations and latest identification approaches coupled with stakeholder involvement will be required to evaluate the possibility of African Sii lineages as novel food-grade Streptococcus lineage. Copyright © 2017 The Authors. Published by

  11. 47{sup th} Annual meeting on nuclear technology (AMNT 2016). Key Topics / Enhanced safety and operation excellence and decommissioning experience and Waste management solutions

    Energy Technology Data Exchange (ETDEWEB)

    Salnikova, Tatiana [AREVA GmbH, Erlangen (Germany); Schaffrath, Andreas [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) gGmbH, Garching (Germany)

    2016-10-15

    Summary report on the Key Topics ''Enhanced Safety and Operation Excellence'' and ''Decommissioning Experience and Waste Management Solutions'' of the 47{sup th} Annual Conference on Nuclear Technology (AMNT 2016) held in Hamburg, 10 to 12 May 2016. Other Sessions of AMNT 2016 have been and will be covered in further issues of atw.

  12. Safety and Efficacy of Gadoxetate Disodium-enhanced Liver Mri in Pediatric Patients Aged >2 Months to <18 Years—Results of a Retrospective, Multicenter Study

    Directory of Open Access Journals (Sweden)

    James Geller

    2016-01-01

    Full Text Available Purpose To assess the safety and efficacy of gadoxetate disodium-enhanced liver MR imaging in pediatric patients. Material and Methods Retrospective, multicenter study including pediatric patients aged >2 months to <18 years who underwent contrast-enhanced liver MRI due to focal liver lesions. A single intravenous bolus injection of 0.025 to 0.05 mmol/kg body weight of gadoxetate disodium was administered. Adverse events (AEs up to 24 hours after injection were recorded and a one-year follow-up was conducted for all serious and unexpected AEs. Efficacy was defined based on the additional diagnostic information obtained from the combined (pre- and postcontrast image sets as compared with the precontrast image sets by blinded reading. Results A total of 52 patients for safety and 51 patients for efficacy analyses were evaluated. Twenty-two patients (42.3% reported a total of 51 serious AEs (SAEs and one AE after one year. No SAE or AE was related to gadoxetate disodium injection. Gadoxetate disodium-related effects on vital signs were not seen. Additional diagnostic information was obtained for 86.3% of patients. The three most improved efficacy variables were lesion-to-background contrast, lesion characterization, and improved border delineation in 78.4%, 76.5%, and 70.6% of patients, respectively. Conclusion Gadoxetate disodium in pediatric patients did not raise any clinically significant safety concern. Contrast enhancement provided additional clinically relevant information.

  13. Reliability Assessment and Reliability-Based Inspection and Maintenance of Offshore Wind Turbines

    DEFF Research Database (Denmark)

    Ramirez, José Rangel

    actions are the most relevant and effective means of control of deterioration. The risk-based inspection planning methodology, based on Bayesian decision theory, represents an important tool to identify the suitable strategy to inspect and control the deterioration in structures such as offshore wind...... performance during the life cycle. The deterioration processes, such as fatigue and corrosion, are typically affecting offshore structural systems. This damage decreases the system performance and increases the risk of failure, thus not fulfilling the established safety criteria. Inspection and maintenance...... to their offshore location, no pollution risks and low human risks since they are unmanned. This allows the allocation of lower reliability level compared to e.g. oil & gas installations. With the incursion to water depths between 20 and 50 meters, the use of jacket and tripod structures represents a feasible...

  14. Reliability-based dynamic positioning of floating vessels with riser and mooring system

    DEFF Research Database (Denmark)

    Fang, Shaoji; Leira, Bernt J.; Blanke, Mogens

    2011-01-01

    To maintain safety of a floating vessel with associated slender components such as risers and mooring line, the vessel is normally kept within a limited region. To specify a safe position in that region, this paper suggests a new position chasing algorithm with the consideration of both riser...... angles and mooring line tensions. The riser angles were considered in an object function in [1] and the mooring line tension was considered in an object function in [2]. The contribution of this paper is to combine riser angle and mooring line tension together in one unified object function....... A combination of scaled riser angles and structural reliability index is utilized to evaluate the “reserve capacity” relative to failure events. With this object function, the riser angles and mooring line tension are considered in a unified formulation, with higher weight added to the riser angles due...

  15. Efficacy, safety and mechanism of HP-β-CD-PEI polymers as absorption enhancers on the intestinal absorption of poorly absorbable drugs in rats.

    Science.gov (United States)

    Zhang, Hailong; Huang, Xiaoyan; Zhang, Yongjing; Gao, Yang

    2017-03-01

    Oral bioavailability of some hydrophilic therapeutic macromolecules was very poor, thus leading to their limited application in clinic. To investigate the efficacy, safety and mechanism of HP-β-CD-PEI polymers on the intestinal absorption of some poorly absorbable drugs in rats. Effects of HP-β-CD-PEI polymers on the intestinal absorptions of drugs were investigated by an in situ closed loop method in rats. The safety of HP-β-CD-PEI polymer was evaluated by measurement of lactate dehydrogenase (LDH) activity and amount of protein released from rat intestinal perfusate. The absorption enhancing mechanisms were explored by the measurement of zeta potential, transepithelial electrical resistance (TEER) and in vitro transport of FD4 (a paracellular marker) across rat intestinal membranes, respectively. HP-β-CD-PEI polymers, especially HP-β-CD-PEI1800, demonstrated excellent absorption enhancing effects on drug absorption in a concentration-dependent manner and the enhancing effect was more efficient in the small intestine than that in the large intestine. Five percent (w/v) HP-β-CD-PEI1800 obviously decreased the TEER, accompanied with increase in the intestinal transport of FD4, indicating that absorption enhancing actions of HP-β-CD-PEI polymers were possibly performed by loosening tight junctions of intestinal epithelium cells, thereby increasing drug permeation via a paracellular pathway. A good liner relationship between absorption enhancing effects of HP-β-CD-PEI polymers and their zeta potentials suggested the contribution of positive charge on the surface of these polymers to their absorption enhancing effects. HP-β-CD-PEI polymers might be potential and safe absorption enhancers for improving oral delivery of poorly absorbable macromolecules including peptides and proteins.

  16. Methodology for reliability based condition assessment. Application to concrete structures in nuclear plants

    Energy Technology Data Exchange (ETDEWEB)

    Mori, Y.; Ellingwood, B. [Johns Hopkins Univ., Baltimore, MD (US). Dept. of Civil Engineering

    1993-08-01

    Structures in nuclear power plants may be exposed to aggressive environmental effects that cause their strength to decrease over an extended period of service. A major concern in evaluating the continued service for such structures is to ensure that in their current condition they are able to withstand future extreme load events during the intended service life with a level of reliability sufficient for public safety. This report describes a methodology to facilitate quantitative assessments of current and future structural reliability and performance of structures in nuclear power plants. This methodology takes into account the nature of past and future loads, and randomness in strength and in degradation resulting from environmental factors. An adaptive Monte Carlo simulation procedure is used to evaluate time-dependent system reliability. The time-dependent reliability is sensitive to the time-varying load characteristics and to the choice of initial strength and strength degradation models but not to correlation in component strengths within a system. Inspection/maintenance strategies are identified that minimize the expected future costs of keeping the failure probability of a structure at or below an established target failure probability during its anticipated service period.

  17. mathematical models for prediction of safety factors for a simply ...

    African Journals Online (AJOL)

    HOD

    The reliability-based calibration of safety factors for the design of a simply supported steel beam, based on BS5950. (2000) is presented in this research work. The calibration was undertaken using a specialized computer program in. Microsoft excel environment developed by the Joint Committee for Structural Safety (JCSS) ...

  18. Current Status of the Preharvest Application of Pro- and Prebiotics to Farm Animals to Enhance the Microbial Safety of Animal Products.

    Science.gov (United States)

    Joerger, Rolf D; Ganguly, Arpeeta

    2017-01-01

    The selection of microorganisms that act as probiotics and feed additives that act as prebiotics is an ongoing research effort, but a sizable range of commercial pro-, pre- and synbiotic (combining pro- and prebiotics) products are already available and being used on farms. A survey of the composition of commercial products available in the United States revealed that Lactobacillus acidophilus, Enterococcus faecium, and Bacillus subtilis were the three most common species in probiotic products. Of the nearly 130 probiotic products (also called direct-fed microbials) for which information was available, about 50 also contained yeasts or molds. The focus on these particular bacteria and eukaryotes is due to long-standing ideas about the benefits of such strains, research data on effectiveness primarily in laboratory or research farm settings, and regulations that dictate which microorganisms or feed additives can be administered to farm animals. Of the direct-fed microbials, only six made a claim relating to food safety or competitive exclusion of pathogens. None of the approximately 50 prebiotic products mentioned food safety in their descriptions. The remainder emphasized enhancement of animal performance such as weight gain or overall animal health. The reason why so few products carry food safety-related claims is the difficulties in establishing unambiguous cause and effect relationships between the application of such products in varied and constantly changing farm environments and improved food safety of the end product.

  19. Reliability-Based Marginal Cost Pricing Problem Case with Both Demand Uncertainty and Travelers’ Perception Errors

    Directory of Open Access Journals (Sweden)

    Shaopeng Zhong

    2013-01-01

    Full Text Available Focusing on the first-best marginal cost pricing (MCP in a stochastic network with both travel demand uncertainty and stochastic perception errors within the travelers’ route choice decision processes, this paper develops a perceived risk-based stochastic network marginal cost pricing (PRSN-MCP model. Numerical examples based on an integrated method combining the moment analysis approach, the fitting distribution method, and the reliability measures are also provided to demonstrate the importance and properties of the proposed model. The main finding is that ignoring the effect of travel time reliability and travelers’ perception errors may significantly reduce the performance of the first-best MCP tolls, especially under high travelers’ confidence and network congestion levels. The analysis result could also enhance our understanding of (1 the effect of stochastic perception error (SPE on the perceived travel time distribution and the components of road toll; (2 the effect of road toll on the actual travel time distribution and its reliability measures; (3 the effect of road toll on the total network travel time distribution and its statistics; and (4 the effect of travel demand level and the value of reliability (VoR level on the components of road toll.

  20. Implementation of an enhanced safety-engineered sharp device oversight and bloodborne pathogen protection program at a large academic medical center.

    Science.gov (United States)

    Talbot, Thomas R; Wang, Deede; Swift, Melanie; St Jacques, Paul; Johnson, Susan; Brinsko, Vicki; Thayer, Valerie; Dail, Teresa; Feistritzer, Nancye; Polancich, Shea

    2014-11-01

    Exposure of healthcare personnel to bloodborne pathogens (BBPs) can be prevented in part by using safety-engineered sharp devices (SESDs) and other safe practices, such as double gloving. In some instances, however, safer devices and practices cannot be utilized because of procedural factors or the lack of a manufactured safety device for the specific clinical use. In these situations, a standardized system to examine requests for waiver from expected practices is necessary. Before-after program analysis. Large academic medical center. Vanderbilt University Medical Center developed a formalized system for an improved waiver process, including an online submission and tracking site, and standards surrounding implementation of core safe practices. The program's impact on sharp device injuries and utilization of double gloving and blunt sutures was examined. Following implementation of the enhanced program, there was an increase in the amount of undergloves and blunt sutures purchased for surgical procedures, suggesting larger utilization of these practices. The rate of sharp device injuries of all at-risk employees decreased from 2.32% to 2.12%, but this decline was not statistically significant (P = .14). The proportion of reported injuries that were deemed preventable significantly decreased from 72.7% (386/531) before implementation to 63.9% (334/523; P = .002) after implementation of the enhanced program. An enhanced BBP protection program was successful at providing guidance to increase safe practices and at improving the management of SESD waiver requests and was associated with a reduction in preventable sharp device injuries.

  1. Dismantlement of nuclear facilities decommissioned from the Russian navy: Enhancing regulatory supervision of nuclear and radiation safety

    Energy Technology Data Exchange (ETDEWEB)

    Sneve, M.K.

    2013-03-01

    The availability of up to date regulatory norms and standards for nuclear and radiation safety, relevant to the management of nuclear legacy situations, combined with effective and efficient regulatory procedures for licensing and monitoring compliance, are considered to be extremely important. Accordingly the NRPA has set up regulatory cooperation programs with corresponding authorities in the Russian Federation. Cooperation began with the civilian regulatory authorities and was more recently extended to include the military authority and this joint cooperation supposed to develop the regulatory documents to improve supervision over nuclear and radiation safety while managing the nuclear military legacy facilities in Northwest Russia and other regions of the country. (Author)

  2. Safety and adverse effects during 24 hours after contrast-enhanced MRI with gadobenate dimeglumine (MultiHance {sup registered}) in children

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Guenther; Schuerholz, Hellmut; Buecker, Arno; Fries, Peter [Homburg University Hospital, Homburg, Saar (Germany); Kirchin, Miles A. [Bracco Imaging SpA, Milan (Italy)

    2013-02-15

    Gadolinium-based MR contrast agents have long been considered safe for routine diagnostic imaging. However, the advent of nephrogenic systemic fibrosis (NSF) among certain patients with severe renal insufficiency has brought the issue of safety into question. Nowhere is safety of greater concern than among children who frequently require multiple contrast-enhanced MRI examinations over an extended period of time. To retrospectively evaluate the safety of gadobenate dimeglumine for contrast-enhanced (CE) MRI across a range of indications. Two hundred pediatric inpatients (age: 4 days to 15 years) underwent CE MRI as part of clinical routine. The children received a gadobenate dimeglumine dose of either 0.05 mmol/kg body weight (liver, abdominal imaging, musculoskeletal imaging, brain and other rare indications) or 0.1 mmol/kg bodyweight (cardiovascular imaging, MR-urography). Young (< 8 years) children with congenital heart disease were intubated and underwent MRA evaluation with controlled ventilation. Monitoring for adverse events was performed for at least 24 h after each gadobenate dimeglumine injection. Depending on clinical necessity, laboratory measurements and, in some cases, vital sign and ECG determinations were made before and after contrast injection. Safety was evaluated by age group, indication and dose administered. No clinically adverse events were reported among children who had one MRI scan only or among children who had several examinations. There were no changes in creatinine or bilirubin levels even in very young children. No adverse events were recorded during the first 24 h following administration of gadobenate dimeglumine in 200 children. (orig.)

  3. Enhancing the implementation of Occupational Health and Safety interventions through a design of the socio-technical interaction

    DEFF Research Database (Denmark)

    Masi, Donato; Cagno, E.; Hasle, Peter

    2014-01-01

    A multitude of Occupational Health and Safety (OHS) interventions have proven to be effective under controlled conditions, but their implementation in practice is often difficult and interventions may therefore not work as expected, especially when referring to Small and Medium sized Enterprises...

  4. Assessing the effectiveness of the Pesticides and Farmworker Health Toolkit: a curriculum for enhancing farmworkers' understanding of pesticide safety concepts.

    Science.gov (United States)

    LePrevost, Catherine E; Storm, Julia F; Asuaje, Cesar R; Arellano, Consuelo; Cope, W Gregory

    2014-01-01

    Among agricultural workers, migrant and seasonal farmworkers have been recognized as a special risk population because these laborers encounter cultural challenges and linguistic barriers while attempting to maintain their safety and health within their working environments. The crop-specific Pesticides and Farmworker Health Toolkit (Toolkit) is a pesticide safety and health curriculum designed to communicate to farmworkers pesticide hazards commonly found in their working environments and to address Worker Protection Standard (WPS) pesticide training criteria for agricultural workers. The goal of this preliminary study was to test evaluation items for measuring knowledge increases among farmworkers and to assess the effectiveness of the Toolkit in improving farmworkers' knowledge of key WPS and risk communication concepts when the Toolkit lesson was delivered by trained trainers in the field. After receiving training on the curriculum, four participating trainers provided lessons using the Toolkit as part of their regular training responsibilities and orally administered a pre- and post-lesson evaluation instrument to 20 farmworker volunteers who were generally representative of the national farmworker population. Farmworker knowledge of pesticide safety messages significantly (PPesticides and Farmworker Health Toolkit is an effective, research-based pesticide safety and health intervention for the at-risk farmworker population and identifies a testing format appropriate for evaluating the Toolkit and other similar interventions for farmworkers in the field.

  5. Design verification enhancement of field programmable gate array-based safety-critical I&C system of nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Ahmed, Ibrahim [Department of Nuclear Engineering, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin-si, Gyeonggi-do 17104 (Korea, Republic of); Jung, Jaecheon, E-mail: jcjung@kings.ac.kr [Department of Nuclear Power Plant Engineering, KEPCO International Nuclear Graduate School, 658-91 Haemaji-ro, Seosang-myeon, Ulju-gun, Ulsan 45014 (Korea, Republic of); Heo, Gyunyoung [Department of Nuclear Engineering, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin-si, Gyeonggi-do 17104 (Korea, Republic of)

    2017-06-15

    Highlights: • An enhanced, systematic and integrated design verification approach is proposed for V&V of FPGA-based I&C system of NPP. • RPS bistable fixed setpoint trip algorithm is designed, analyzed, verified and discussed using the proposed approaches. • The application of integrated verification approach simultaneously verified the entire design modules. • The applicability of the proposed V&V facilitated the design verification processes. - Abstract: Safety-critical instrumentation and control (I&C) system in nuclear power plant (NPP) implemented on programmable logic controllers (PLCs) plays a vital role in safe operation of the plant. The challenges such as fast obsolescence, the vulnerability to cyber-attack, and other related issues of software systems have currently led to the consideration of field programmable gate arrays (FPGAs) as an alternative to PLCs because of their advantages and hardware related benefits. However, safety analysis for FPGA-based I&C systems, and verification and validation (V&V) assessments still remain important issues to be resolved, which are now become a global research point of interests. In this work, we proposed a systematic design and verification strategies from start to ready-to-use in form of model-based approaches for FPGA-based reactor protection system (RPS) that can lead to the enhancement of the design verification and validation processes. The proposed methodology stages are requirement analysis, enhanced functional flow block diagram (EFFBD) models, finite state machine with data path (FSMD) models, hardware description language (HDL) code development, and design verifications. The design verification stage includes unit test – Very high speed integrated circuit Hardware Description Language (VHDL) test and modified condition decision coverage (MC/DC) test, module test – MATLAB/Simulink Co-simulation test, and integration test – FPGA hardware test beds. To prove the adequacy of the proposed

  6. 46{sup th} Annual meeting on nuclear technology (AMNT 2015). Key topic / Enhanced safety and operation excellence / Sustainable reactor operation management - safe, efficient, valuable

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Erwin [E.ON Kernkraft GmbH, Global Unit Next Generation, Hannover (Germany)

    2015-08-15

    Summary report on the following Topical Session of the 46{sup th} Annual Conference on Nuclear Technology (AMNT 2015) held in Berlin, 5 to 7 May 2015: - Sustainable Reactor Operation Management - Safe, Efficient, Valuable (Erwin Fischer) The other Sessions of the Key Topics - ''Outstanding Know-How and Sustainable Innovations'', - ''Enhanced Safety and Operation Excellence'' and - ''Decommissioning Experience and Waste Management Solutions'' have been covered in atw 7 (2015) and will be covered in further issues of atw.

  7. Partial Safety Factors and Target Reliability Level in Danish Structural Codes

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Hansen, J. O.; Nielsen, T. A.

    2001-01-01

    The partial safety factors in the newly revised Danish structural codes have been derived using a reliability-based calibration. The calibrated partial safety factors result in the same average reliability level as in the previous codes, but a much more uniform reliability level has been obtained....... The paper describes the code format, the stochastic models and the resulting optimised partial safety factors....

  8. Oxygen safety

    Science.gov (United States)

    COPD - oxygen safety; Chronic obstructive pulmonary disease - oxygen safety; Chronic obstructive airways disease - oxygen safety; Emphysema - oxygen safety; Heart failure - oxygen-safety; Palliative care - oxygen safety; Hospice - oxygen safety

  9. Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans

    OpenAIRE

    Wichit Suthammarak; Pornpayom Numpraphrut; Ratiya Charoensakdi; Neelobol Neungton; Vachara Tunrungruangtavee; Nattapon Jaisupa; Suwit Charoensak; Primchanien Moongkarndi; Weerasak Muangpaisan

    2016-01-01

    Crude extract from the pericarp of the mangosteen (mangosteen extract [ME]) has exhibited several medicinal properties in both animal models and human cell lines. Interestingly, the cytotoxic activities were always observed in nonpolar fraction of the extract whereas the potent antioxidant was often found in polar fraction. Although it has been demonstrated that the polar fraction of ME exhibited the antioxidant activity, the safety of the polar fraction of ME has never been thoroughly invest...

  10. Online continuing education course enhances nutrition and health professionals' knowledge of food safety issues of high-risk populations.

    Science.gov (United States)

    Wallner, Stephanie; Kendall, Patricia; Hillers, Virginia; Bradshaw, Eva; Medeiros, Lydia C

    2007-08-01

    To develop and evaluate the efficacy of an online continuing education course for professionals who provide food safety information to high-risk populations. A 2-credit graduate-level class was converted into six web-based modules (overview of foodborne illness, immunology, pregnancy, human immunodeficiency virus, cancer and transplants, and lifecycle) and offered to nutrition and health professionals. Participants had 8 weeks to complete the modules, pre and post questionnaires, and course evaluation. Those who successfully completed the protocol received six continuing education units from one of three professional associations. Change in knowledge was measured using pre and post questionnaires. Course efficacy was evaluated using a post-course questionnaire. A convenience sample of 140 registered dietitians/dietetic technicians registered, nurses, and extension educators were recruited through professional conferences and electronic mailing lists to take the course. Analysis of variance was used to evaluate differences in knowledge scores for all groups across five main effects (attempt, module, profession, age, and education). Course evaluation responses were used to assess course effectiveness. For each module, knowledge scores increased significantly (POnline continuing education courses, such as "Food Safety Issues for High Risk Populations," seem to be a convenient, effective option for dietetics professionals, nurses, and extension educators seeking knowledge about food safety issues of high-risk populations. Online learning is a promising delivery approach for the continuing education of health professionals.

  11. Enhanced

    Directory of Open Access Journals (Sweden)

    Martin I. Bayala

    2014-06-01

    Full Text Available Land Surface Temperature (LST is a key parameter in the energy balance model. However, the spatial resolution of the retrieved LST from sensors with high temporal resolution is not accurate enough to be used in local-scale studies. To explore the LST–Normalised Difference Vegetation Index relationship potential and obtain thermal images with high spatial resolution, six enhanced image sharpening techniques were assessed: the disaggregation procedure for radiometric surface temperatures (TsHARP, the Dry Edge Quadratic Function, the Difference of Edges (Ts∗DL and three models supported by the relationship of surface temperature and water stress of vegetation (Normalised Difference Water Index, Normalised Difference Infrared Index and Soil wetness index. Energy Balance Station data and in situ measurements were used to validate the enhanced LST images over a mixed agricultural landscape in the sub-humid Pampean Region of Argentina (PRA, during 2006–2010. Landsat Thematic Mapper (TM and Moderate Resolution Imaging Spectroradiometer (EOS-MODIS thermal datasets were assessed for different spatial resolutions (e.g., 960, 720 and 240 m and the performances were compared with global and local TsHARP procedures. Results suggest that the Ts∗DL technique is the most adequate for simulating LST to high spatial resolution over the heterogeneous landscape of a sub-humid region, showing an average root mean square error of less than 1 K.

  12. Safety, Tolerance, and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With Fenugreek Dietary Fiber on Occupational Stress: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.

    Science.gov (United States)

    Pandaran Sudheeran, Subash; Jacob, Della; Natinga Mulakal, Johannah; Gopinathan Nair, Gopakumar; Maliakel, Abhilash; Maliakel, Balu; Kuttan, Ramadasan; Im, Krishnakumar

    2016-06-01

    Drug delivery systems capable of delivering free (unconjugated) curcuminoids is of great therapeutic significance, since the absorption of bioactive and permeable form plays a key factor in mediating the efficacy of a substance which undergoes rapid biotransformation. Considering the recent understanding on the relatively high bioactivities and blood-brain-barrier permeability of free curcuminoids over their conjugated metabolites, the present human study investigated the safety, antioxidant efficacy, and bioavailability of CurQfen (curcumagalactomannoside [CGM]), a food-grade formulation of natural curcumin with fenugreek dietary fiber that has shown to possess improved blood-brain-barrier permeability and tissue distribution in rats. In this randomized double-blinded and placebo-controlled trial, 60 subjects experiencing occupational stress-related anxiety and fatigue were randomized to receive CGM, standard curcumin, and placebo for 30 days (500 mg twice daily). The study demonstrated the safety, tolerance, and enhanced efficacy of CGM in comparison with unformulated standard curcumin. A significant improvement in the quality of life (P comparison of the free curcuminoids bioavailability after a single-dose (500 mg once per day) and repeated-dose (500 mg twice daily for 30 days) oral administration revealed enhanced absorption and improved pharmacokinetics of CGM upon both single- (30.7-fold) and repeated-dose (39.1-fold) administrations.

  13. Safety first!

    CERN Multimedia

    2016-01-01

    Among the many duties I assumed at the beginning of the year was the ultimate responsibility for Safety at CERN: the responsibility for the physical safety of the personnel, the responsibility for the safe operation of the facilities, and the responsibility to ensure that CERN acts in accordance with the highest standards of radiation and environmental protection.   The Safety Policy document drawn up in September 2014 is an excellent basis for the implementation of Safety in all areas of CERN’s work. I am happy to commit during my mandate to help meet its objectives, not least by ensuring the Organization makes available the necessary means to achieve its Safety objectives. One of the main objectives of the HSE (Occupational Health and Safety and Environmental Protection) unit in the coming months is to enhance the measures to minimise CERN’s impact on the environment. I believe CERN should become a role model for an environmentally-aware scientific research laboratory. Risk ...

  14. Dry-heat treatment process for enhancing viral safety of an antihemophilic factor VIII concentrate prepared from human plasma.

    Science.gov (United States)

    Kim, In Seop; Choi, Yong Woon; Kang, Yong; Sung, Hark Mo; Shin, Jeong Sup

    2008-05-01

    Viral safety is a prerequisite for manufacturing clinical antihemophilic factor VIII concentrates from human plasma. With particular regard to the hepatitis A virus (HAV), a terminal dry-heat treatment (100 degrees for 30 min) process, following lyophilization, was developed to improve the virus safety of a solvent/detergent-treated antihemophilic factor VIII concentrate. The loss of factor VIII activity during dry-heat treatment was of about 5%. No substantial changes were observed in the physical and biochemical characteristics of the dry-heat-treated factor VIII compared with those of the factor VIII before dry-heat treatment. The dry-heat-treated factor VIII was stable for up to 24 months at 4oC. The dry-heat treatment after lyophilization was an effective process for inactivating viruses. The HAV, murine encephalomyocarditis virus (EMCV), and human immunodeficiency virus (HIV) were completely inactivated to below detectable levels within 10 min of the dry-heat treatment. Bovine herpes virus (BHV) and bovine viral diarrhea virus (BVDV) were potentially sensitive to the treatment. However porcine parvovirus (PPV) was slightly resistant to the treatment. The log reduction factors achieved during lyophilization and dry-heat treatment were > or =5.55 for HAV, > or =5.87 for EMCV, > or =5.15 for HIV, 6.13 for BHV, 4.46 for BVDV, and 1.90 for PPV. These results indicate that dry-heat treatment improves the virus safety of factor VIII concentrates, without destroying the activity. Moreover, the treatment represents an effective measure for the inactivation of non-lipid-enveloped viruses, in particular HAV, which is resistant to solvent/detergent treatment.

  15. Reliability based structural design

    NARCIS (Netherlands)

    Vrouwenvelder, A.C.W.M.

    2013-01-01

    According to ISO 2394, structures shall be designed, constructed and maintained in such a way that they are suited for their use during the design working life in an economic way. To fulfil this requirement one needs insight into the risk and reliability under expected and non-expected actions. A

  16. Toward a treaty on safety and cost-effectiveness of pharmaceuticals and medical devices: enhancing an endangered global public good

    Directory of Open Access Journals (Sweden)

    Faunce Thomas

    2006-03-01

    Full Text Available Abstract • Expert evaluations of the safety, efficacy and cost-effectiveness of pharmaceutical and medical devices, prior to marketing approval or reimbursement listing, collectively represent a globally important public good. The scientific processes involved play a major role in protecting the public from product risks such as unintended or adverse events, sub-standard production and unnecessary burdens on individual and governmental healthcare budgets. • Most States now have an increasing policy interest in this area, though institutional arrangements, particularly in the area of cost-effectiveness analysis of medical devices, are not uniformly advanced and are fragile in the face of opposing multinational industry pressure to recoup investment and maintain profit margins. • This paper examines the possibility, in this context, of States commencing negotiations toward bilateral trade agreement provisions, and ultimately perhaps a multilateral Treaty, on safety, efficacy and cost-effectiveness analysis of pharmaceuticals and medical devices. Such obligations may robustly facilitate a conceptually interlinked, but endangered, global public good, without compromising the capacity of intellectual property laws to facilitate local product innovations.

  17. Enhancing the role of case-oriented peer review to improve quality and safety in radiation oncology: Executive summary.

    Science.gov (United States)

    Marks, Lawrence B; Adams, Robert D; Pawlicki, Todd; Blumberg, Albert L; Hoopes, David; Brundage, Michael D; Fraass, Benedick A

    2013-07-01

    This report is part of a series of white papers commissioned for the American Society for Radiation Oncology (ASTRO) Board of Directors as part of ASTRO's Target Safely Campaign, focusing on the role of peer review as an important component of a broad safety/quality assurance (QA) program. Peer review is one of the most effective means for assuring the quality of qualitative, and potentially controversial, patient-specific decisions in radiation oncology. This report summarizes many of the areas throughout radiation therapy that may benefit from the application of peer review. Each radiation oncology facility should evaluate the issues raised and develop improved ways to apply the concept of peer review to its individual process and workflow. This might consist of a daily multidisciplinary (eg, physicians, dosimetrists, physicists, therapists) meeting to review patients being considered for, or undergoing planning for, radiation therapy (eg, intention to treat and target delineation), as well as meetings to review patients already under treatment (eg, adequacy of image guidance). This report is intended to clarify and broaden the understanding of radiation oncology professionals regarding the meaning, roles, benefits, and targets for peer review as a routine quality assurance tool. It is hoped that this work will be a catalyst for further investigation, development, and study of the efficacy of peer review techniques and how these efforts can help improve the safety and quality of our treatments.

  18. Using antibrowning agents to enhance quality and safety of fresh-cut avocado treated with intense light pulses.

    Science.gov (United States)

    Ramos-Villarroel, Ana Y; Martín-Belloso, Olga; Soliva-Fortuny, Robert

    2011-01-01

    The effect of antibrowning compounds on the color and firmness of fresh-cut avocado treated with intense light pulses (ILP), as well as their impact on the survival of Listeria innocua, was investigated in this study. Dipping solutions containing 2% (w/v) L-cysteine without ascorbic acid and combined with 1% (w/v) citric acid and 1% w/v calcium lactate most effectively preserved the initial color and texture of ILP-treated fresh-cut avocado. On the other hand, ILP treatments caused a reduction of more than 3 log cycles in the populations of L. innocua inoculated on fresh-cut avocado. Log reduction levels increased when antibrowning agents were combined with ILP treatments. In conclusion, the use of quality-stabilizing agents is a good option to guarantee both the microbiological safety of fresh-cut avocado treated with ILP as well as to improve its physical and chemical quality. Intense light pulses (ILP) have received considerable attention during the last years after its approval by the U.S. Food and Drug Administration (FDA) in 1996 as a decontamination method for food or food surfaces. This article presents relevant information regarding the effect of ILP treatments combined with quality-stabilizing compounds as a feasible alternative to improve the physical and chemical quality of fresh-cut avocado as well as to guarantee its microbiological safety. © 2011 Institute of Food Technologists®

  19. Polypropylene/hydrophobic-silica-aerogel-composite separator induced enhanced safety and low polarization for lithium-ion batteries

    Science.gov (United States)

    Feng, Guanhua; Li, Zihe; Mi, Liwei; Zheng, Jinyun; Feng, Xiangming; Chen, Weihua

    2018-02-01

    Separator as an important part of lithium-ion batteries, allowing the ion to transfer and preventing the direct contact of anode with cathode, determines the safety of the batteries. In this work, a kind of polypropylene/hydrophobic silica-aerogel-composite (SAC) separator is fabricated through combining hydrophobic silica aerogel and polypropylene (PP) separator. The rationally designed SAC effectively increases the thermal stability of the separator with slightly growing weight (the area retention rate is 30% higher than that of the PP separator after being heated for 30 min at 160 °C). In addition, the hydrophobic silica aerogel layer in SAC significantly improves the wettability of PP separator to electrolyte owning to the introduced hydrophobic functional groups of -Si(CH3)3 and porous structure, and the contact angles of SAC separator to several common organic electrolytes (EC/DMC, DMC/DOL, Diglyme) are close to 0°. Electrochemical tests show that the prepared SAC separator can decrease the polarization of Li-ion batteries and leads to improved power performance and cycle stability. And the SAC separator is firm with neglectable abscission after folding 200 times. This work provides a new way to improve the safety and simultaneously reduce the polarization of the batteries, implying promising application potential in power batteries.

  20. DOE handbook electrical safety

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-01

    Electrical Safety Handbook presents the Department of Energy (DOE) safety standards for DOE field offices or facilities involved in the use of electrical energy. It has been prepared to provide a uniform set of electrical safety guidance and information for DOE installations to effect a reduction or elimination of risks associated with the use of electrical energy. The objectives of this handbook are to enhance electrical safety awareness and mitigate electrical hazards to employees, the public, and the environment.

  1. Electrical safety guidelines

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-01

    The Electrical Safety Guidelines prescribes the DOE safety standards for DOE field offices or facilities involved in the use of electrical energy. It has been prepared to provide a uniform set of electrical safety standards and guidance for DOE installations in order to affect a reduction or elimination of risks associated with the use of electrical energy. The objectives of these guidelines are to enhance electrical safety awareness and mitigate electrical hazards to employees, the public, and the environment.

  2. SU-E-T-785: Using Systems Engineering to Design HDR Skin Treatment Operation for Small Lesions to Enhance Patient Safety

    Energy Technology Data Exchange (ETDEWEB)

    Saw, C; Baikadi, M; Peters, C; Brereton, H [Northeast Radiation Oncology Centers, Harrisburg, PA (United States)

    2015-06-15

    Purpose: Using systems engineering to design HDR skin treatment operation for small lesions using shielded applicators to enhance patient safety. Methods: Systems engineering is an interdisciplinary field that offers formal methodologies to study, design, implement, and manage complex engineering systems as a whole over their life-cycles. The methodologies deal with human work-processes, coordination of different team, optimization, and risk management. The V-model of systems engineering emphasize two streams, the specification and the testing streams. The specification stream consists of user requirements, functional requirements, and design specifications while the testing on installation, operational, and performance specifications. In implementing system engineering to this project, the user and functional requirements are (a) HDR unit parameters be downloaded from the treatment planning system, (b) dwell times and positions be generated by treatment planning system, (c) source decay be computer calculated, (d) a double-check system of treatment parameters to comply with the NRC regulation. These requirements are intended to reduce human intervention to improve patient safety. Results: A formal investigation indicated that the user requirements can be satisfied. The treatment operation consists of using the treatment planning system to generate a pseudo plan that is adjusted for different shielded applicators to compute the dwell times. The dwell positions, channel numbers, and the dwell times are verified by the medical physicist and downloaded into the HDR unit. The decayed source strength is transferred to a spreadsheet that computes the dwell times based on the type of applicators and prescribed dose used. Prior to treatment, the source strength, dwell times, dwell positions, and channel numbers are double-checked by the radiation oncologist. No dosimetric parameters are manually calculated. Conclusion: Systems engineering provides methodologies to

  3. Safety of meglumine gadoterate (Gd-DOTA)-enhanced MRI compared to unenhanced MRI in patients with chronic kidney disease (RESCUE study)

    Energy Technology Data Exchange (ETDEWEB)

    Deray, Gilbert [Pitie Salpetriere Hospital, Department of Nephrology, Paris cedex 13 (France); Rouviere, Olivier [Hopital E. Herriot, Universite de Lyon, Hospices Civils de Lyon, Department of Urinary and Vascular Imaging, Lyon (France); Universite Lyon 1, faculte de medecine Lyon Est, Lyon (France); Bacigalupo, Lorenzo [E.O. Ospedali Galliera, Radiology Department, Genova (Italy); Maes, Bart [Heilig Hartziekenhuis Roeselare, Department of Nephrology, Roeselare (Belgium); Hannedouche, Thierry [University Hospitals, Department of Nephrology, Strasbourg (France); Vrtovsnik, Francois [Bichat Hospital, Department of Nephrology, Paris (France); Rigothier, Claire [Pellegrin Hospital, Department of Nephrology Transplantation Dialysis, Bordeaux (France); Billiouw, Jean-Marie [Onze Lieve Vrouw Ziekenhuis, Department of Nephrology, Aalst (Belgium); Campioni, Paolo [Azienda Ospedaliero-Universitaria Sant' Anna, Ferrara (Italy); Ferreiros, Joaquin [Hospital Clinico de San Carlos, Servicio de Radiodiagnostico, Madrid (Spain); Devos, Daniel [Gent University Hospital, Department of Radiology, Gent (Belgium); Alison, Daniel [Trousseau Hospital, Department of Radiology, Tours (France); Glowacki, Francois [University Hospitals, Department of Nephrology, Lille (France); Boffa, Jean-Jacques [Tenon Hospital, Department of Nephrology and Dialysis, Paris (France); Marti-Bonmati, Luis [University of Valencia, Department of Radiology, Valencia (Spain)

    2013-05-15

    To prospectively compare the renal safety of meglumine gadoterate (Gd-DOTA)-enhanced magnetic resonance imaging (MRI) to a control group (unenhanced MRI) in high-risk patients. Patients with chronic kidney disease (CKD) scheduled for MRI procedures were screened. The primary endpoint was the percentage of patients with an elevation of serum creatinine levels, measured 72 {+-} 24 h after the MRI procedure, by at least 25 % or 44.2 {mu}mol/l (0.5 mg/dl) from baseline. A non-inferiority margin of the between-group difference was set at -15 % for statistical analysis of the primary endpoint. Main secondary endpoints were the variation in serum creatinine and eGFR values between baseline and 72 {+-} 24 h after MRI and the percentage of patients with a decrease in eGFR of at least 25 % from baseline. Patients were screened for signs of nephrogenic systemic fibrosis (NSF) at 3-month follow-up. Among the 114 evaluable patients, one (1.4 %) in the Gd-DOTA-MRI group and none in the control group met the criteria of the primary endpoint [{Delta} = -1.4 %, 95%CI = (-7.9 %; 6.7 %)]. Non-inferiority was therefore demonstrated (P = 0.001). No clinically significant differences were observed between groups for the secondary endpoints. No serious safety events (including NSF) were noted. Meglumine gadoterate did not affect renal function and was a safe contrast agent in patients with CKD. (orig.)

  4. The value of Doppler LiDAR systems to monitor turbulence intensity during storm events in order to enhance aviation safety in Iceland

    Science.gov (United States)

    Yang, Shu; Nína Petersen, Guðrún; Finger, David C.

    2017-04-01

    Turbulence and wind shear are a major natural hazards for aviation safety in Iceland. The temporal and spatial scale of atmospheric turbulence is very dynamic, requiring an adequate method to detect and monitor turbulence with high resolution. The Doppler Light Detection and Ranging (LiDAR) system can provide continuous information about the wind field using the Doppler effect form emitted light signals. In this study, we use a Leosphere Windcube 200s LiDAR systems stationed near Reykjavik city Airport and at Keflavik International Airport, Iceland, to evaluate turbulence intensity by estimating eddy dissipation rate (EDR). For this purpose, we retrieved radial wind velocity observations from Velocity Azimuth Display (VAD) scans (360°scans at 15° and 75° elevation angle) to compute EDR. The method was used to monitor and characterize storm events in fall 2016 and the following winter. The preliminary result reveal that the LiDAR observations can detect and quantify atmospheric turbulence with high spatial and temporal resolution. This finding is an important step towards enhanced aviation safety in subpolar climate characterized by sever wind turbulence.

  5. Exposing exposure: enhancing patient safety through automated data mining of nuclear medicine reports for quality assurance and organ dose monitoring.

    Science.gov (United States)

    Ikuta, Ichiro; Sodickson, Aaron; Wasser, Elliot J; Warden, Graham I; Gerbaudo, Victor H; Khorasani, Ramin

    2012-08-01

    To develop and validate an open-source informatics toolkit capable of creating a radiation exposure data repository from existing nuclear medicine report archives and to demonstrate potential applications of such data for quality assurance and longitudinal patient-specific radiation dose monitoring. This study was institutional review board approved and HIPAA compliant. Informed consent was waived. An open-source toolkit designed to automate the extraction of data on radiopharmaceuticals and administered activities from nuclear medicine reports was developed. After iterative code training, manual validation was performed on 2359 nuclear medicine reports randomly selected from September 17, 1985, to February 28, 2011. Recall (sensitivity) and precision (positive predictive value) were calculated with 95% binomial confidence intervals. From the resultant institutional data repository, examples of usage in quality assurance efforts and patient-specific longitudinal radiation dose monitoring obtained by calculating organ doses from the administered activity and radiopharmaceutical of each examination were provided. Validation statistics yielded a combined recall of 97.6% ± 0.7 (95% confidence interval) and precision of 98.7% ± 0.5. Histograms of administered activity for fluorine 18 fluorodeoxyglucose and iodine 131 sodium iodide were generated. An organ dose heatmap which displays a sample patient's dose accumulation from multiple nuclear medicine examinations was created. Large-scale repositories of radiation exposure data can be extracted from institutional nuclear medicine report archives with high recall and precision. Such repositories enable new approaches in radiation exposure patient safety initiatives and patient-specific radiation dose monitoring.

  6. Multidisciplinary Testing of Floor Pads on Stability, Energy Absorption, and Ease of Hospital Use for Enhanced Patient Safety.

    Science.gov (United States)

    Crane, Barbara; Goodworth, Adam D; Liquori, Melissa; Ghosh, Suhash; Certo, Catherine; McCafferty, Lorraine

    2016-09-01

    A major improvement in hospital safety could be realized if serious injury did not accompany falls. We studied several commercially available floor pads made of different materials to determine which (if any) would be practical in a hospital room and reduce injury without posing a threat to the balance of patients. A multidisciplinary approach was undertaken to (1) measure upper and lower body motion in 17 young (55 years) adults during an instrumented sit to stand test from a hospital bed onto the different floor pads, (2) predict the energy dissipation available in floor pads by quantifying the relative mechanical properties, and (3) obtain professional feedback from hospital nurses via a questionnaire (8 questions) following a period of working on the different floor pads. Five floor pads, composed of foam, gel, and/or rubber were tested. All pads were compared with a typical hospital floor (concrete covered with linoleum tiles, considered the control). All of the pads subject to mechanical testing showed at least 3 times more energy absorption compared with the control. Balance testing showed that three of the pads resulted in minimal or no significant increases in body motion during sit-to-stand. Nursing feedback revealed that only 2 of these 3 pads may be feasible for hospital room use: one made primarily of firm rubber and one made of foam. Floor pads do exist that show promise for hospital use that absorbing energy without major impacts on balance during sit-to-stand. Although only commercially available pads were investigated, results may inform the design and multidisciplinary testing of other floor surfaces.

  7. Comparative safety and effectiveness of cognitive enhancers for Alzheimer's dementia: protocol for a systematic review and individual patient data network meta-analysis

    Science.gov (United States)

    Veroniki, Areti Angeliki; Straus, Sharon E; Ashoor, Huda M; Hamid, Jemila S; Hemmelgarn, Brenda R; Holroyd-Leduc, Jayna; Majumdar, Sumit R; McAuley, Glenn; Tricco, Andrea C

    2016-01-01

    Introduction Alzheimer's dementia (AD) is the most common cause of dementia, and several organisations, such as the National Institute for Health and Care Excellence, suggest that management of patients with AD should be tailored to their needs. To date, little research has been conducted on the treatment effect in different subgroups of patients with AD. The aim of this study is to examine the comparative effectiveness and safety of cognitive enhancers for different patient characteristics. Methods and analysis We will update our previous literature search from January 2015 forward, using the same terms and electronic databases (eg, MEDLINE) from our previous review. We will additionally search grey literature and scan the reference lists of the included studies. Randomised clinical trials of any duration conducted at any time comparing cognitive enhancers alone or in any combination against other cognitive enhancers, or placebo in adults with AD will be eligible. The outcomes of interest are cognition according to the Mini-Mental State Examination, and overall serious adverse events. For each outcome and treatment comparison, we will perform a Bayesian hierarchical random-effects meta-analysis combining the individual patient data (IPD) from each eligible study. If the identified treatment comparisons form a connected network diagram, we will perform an IPD network meta-analysis (NMA) to estimate subgroup effects for patients with different characteristics, such as AD severity and sex. We will combine aggregated data from studies that we will not be able to obtain IPD, with the IPD provided by the original authors, in a single model. We will use the PRISMA-IPD and PRISMA-NMA statements to report our findings. Ethics and dissemination The findings of this study will be of interest to stakeholders, including decision makers, guideline developers, clinicians, methodologists and patients, and they will help to improve guidelines for the management of patients with AD

  8. The safety and efficacy of enhanced external counterpulsation as a treatment for angina in patients with aortic stenosis.

    Science.gov (United States)

    Braverman, Debra L; Braitman, Len; Figueredo, Vincent M; Figeuredo, Vincent M

    2013-02-01

    Comorbid aortic stenosis (AS) has been considered a precaution when applying enhanced external counterpulsation (EECP) to individuals with angina due to concerns about treatment-related hemodynamic changes. The aim of this study was to determine whether EECP safely reduces symptoms of myocardial ischemia and improves hemodynamics in individuals with AS. Forty-three patients with AS (average age, 73 years; 86% male) and 43 comparison patients without AS were chosen from a database of 1327 EECP patients. Canadian Cardiovascular Society (CCS) Functional Angina Classification, diastolic augmentation ratio, and blood pressure were measured at baseline and on completion of the course of EECP. Thirty-five of the 43 patients with AS (81%, 95% CI: 66.6% to 91.6%) and 38 of the 43 without AS (88%, 95% CI: 74.9% to 96.1%) improved in angina class (P angina class outcome was not associated with AS severity (P = 0.55). The percentage of patients with diastolic augmentation ratio ≥1.0 was 16.3% in both groups at baseline and improved to 39.5% in AS patients and 37.2% in non-AS patients after EECP (both P = 0.002). The average decreases in systolic blood pressure in subjects with AS (-15 mm Hg, 95% CI: 11 to 20, P Angina patients with AS who undergo EECP had clinically important symptomatic and hemodynamic improvements comparable to their non-AS counterparts. © 2012 Wiley Periodicals, Inc.

  9. Nuclear safety in perspective

    DEFF Research Database (Denmark)

    Andersson, K.; Sjöberg, B.M.D.; Lauridsen, Kurt

    2003-01-01

    The aim of the NKS/SOS-1 project has been to enhance common understanding about requirements for nuclear safety by finding improved means of communicat-ing on the subject in society. The project, which has been built around a number of seminars, wassupported by limited research in three sub......-projects: Risk assessment Safety analysis Strategies for safety management The report describes an industry in change due to societal factors. The concepts of risk and safety, safety management and systems forregulatory oversight are de-scribed in the nuclear area and also, to widen the perspective, for other...

  10. Immune enhancement by novel vaccine adjuvants in autoimmune-prone NZB/W F1 mice: relative efficacy and safety

    Directory of Open Access Journals (Sweden)

    Ghosh Swapan K

    2011-10-01

    Full Text Available Abstract Background Vaccines have profoundly impacted global health although concerns persist about their potential role in autoimmune or other adverse reactions. To address these concerns, vaccine components like immunogens and adjuvants require critical evaluation not only in healthy subjects but also in those genetically averse to vaccine constituents. Evaluation in autoimmune-prone animal models of adjuvants is therefore important in vaccine development. The objective here was to assess the effectiveness of experimental adjuvants: two phytol-derived immunostimulants PHIS-01 (phytanol and PHIS-03 (phytanyl mannose, and a new commercial adjuvant from porcine small intestinal submucosa (SIS-H, relative to a standard adjuvant alum. Phytol derivatives are hydrophobic, oil-in water diterpenoids, while alum is hydrophilic, and SIS is essentially a biodegradable and collagenous protein cocktail derived from extracellular matrices. Results We studied phthalate -specific and cross-reactive anti-DNA antibody responses, and parameters associated with the onset of autoimmune disorders. We determined antibody isotype and cytokine/chemokine milieu induced by the above experimental adjuvants relative to alum. Our results indicated that the phytol-derived adjuvant PHIS-01 exceeded alum in enhancing anti-phthalate antibody without much cross reactivity with ds-DNA. Relatively, SIS and PHIS-03 proved less robust, but they were also less inflammatory. Interestingly, these adjuvants facilitated isotype switching of anti-hapten, but not of anti-DNA response. The current study reaffirms our earlier reports on adjuvanticity of phytol compounds and SIS-H in non autoimmune-prone BALB/c and C57BL/6 mice. These adjuvants are as effective as alum also in autoimmune-prone NZB/WF1 mice, and they have little deleterious effects. Conclusion Although all adjuvants tested impacted cytokine/chemokine milieu in favor of Th1/Th2 balance, the phytol compounds fared better in

  11. New technologies to enhance quality and safety of table eggs: ultra-violet treatment and modified atmosphere packaging

    Directory of Open Access Journals (Sweden)

    Frédérique Pasquali

    2014-12-01

    Full Text Available In the present study the effect of ultra-violet (UV treatment alone and in combination with 100% CO2 modified atmosphere packaging (MAP was evaluated both on the survival of naturally occurring bacteria, as well as on quality parameters of table eggs during 28 days of storage at 21°C. Table eggs were collected from the conveyor belt after the UV module, and placed on carton trays. A representative number of carton trays were packed in a high barrier multilayer pouch filled with 100% CO2. All eggs were stored at 21°C and analysed at 0, 1, 7, 14, 21 and 28 days of storage. Eggs not treated with UV and not packed were also included. On the eggshells total colony count, total coliforms and faecal coliforms counts, as well as the detection of Salmonella spp. were investigated. Moreover, chemical-functional parameters such as weight loss, albumen pH and Haugh Unit (HU were evaluated. The total colony count on UV treated table eggs was approximately 1 log10 CFU/g lower than untreated eggs (2.27 vs 3.29 log10 CFU/g. During storage, CO2 packed eggs maintained the initial values of HU, whereas the albumen pH decreased up to 1.5-2 points in comparison to unpacked eggs. The UV treatment was effective in reducing the total colony count on the surface of table eggs. MAP showed a great potential in maintaining/enhance the technological properties of egg constituents (higher foam stability of the albumen for meringue preparation without significantly impacting on the microbial load of table eggs.

  12. Safety Climate of Commercial Vehicle Operation

    Science.gov (United States)

    2010-03-01

    Enhancing the safety culture within trucking and motor coach industries has become a key area of concern given the potential impact it has on crashes and overall safety. Many organizations recognize that safety is compromised if the culture within th...

  13. Building an immune-mediated coagulopathy consensus: early recognition and evaluation to enhance post-surgical patient safety

    Directory of Open Access Journals (Sweden)

    Voils Stacy A

    2009-05-01

    Full Text Available Abstract Topical hemostats, fibrin sealants, and surgical adhesives are regularly used in a variety of surgical procedures involving multiple disciplines. Generally, these adjuncts to surgical hemostasis are valuable means for improving wound visualization, reducing blood loss or adding tissue adherence; however, some of these agents are responsible for under-recognized adverse reactions and outcomes. Bovine thrombin, for example, is a topical hemostat with a long history of clinical application that is widely used alone or in combination with other hemostatic agents. Hematologists and coagulation experts are aware that these agents can lead to development of an immune-mediated coagulopathy (IMC. A paucity of data on the incidence of IMC contributes to under-recognition and leaves many surgeons unaware that this clinical entity, originating from normal immune responses to foreign antigen exposure, requires enhanced post-operative vigilance and judicious clinical judgment to achieve best outcomes. Postoperative bleeding may result from issues such as loosened ties or clips or the occurrence of a coagulopathy due to hemodilution, vitamin K deficiency, disseminated intravascular coagulation (DIC or post-transfusion, post-shock coagulopathic states. Other causes, such as liver disease, may be ruled out by a careful patient history and common pre-operative liver function tests. Less common are coagulopathies secondary to pathologic immune responses. Such coagulopathies include those that may result from inherent patient problems such as patients with an immune dysfunction related to systemic lupus erythrematosus (SLE or lymphoma that can invoke antibodies against native coagulation factors. Medical interventions may also provoke antibody formation in the form of self-directed anti-coagulation factor antibodies, that result in problematic bleeding; it is these iatrogenic post-operative coagulopathies, including those associated with bovine thrombin

  14. MRI active guidewire with an embedded temperature probe and providing a distinct tip signal to enhance clinical safety

    Directory of Open Access Journals (Sweden)

    Sonmez Merdim

    2012-06-01

    Full Text Available Abstract Background The field of interventional cardiovascular MRI is hampered by the unavailability of active guidewires that are both safe and conspicuous. Heating of conductive guidewires is difficult to predict in vivo and disruptive to measure using external probes. We describe a clinical-grade 0.035” (0.89 mm guidewire for MRI right and left heart catheterization at 1.5 T that has an internal probe to monitor temperature in real-time, and that has both tip and shaft visibility as well as suitable flexibility. Methods The design has an internal fiberoptic temperature probe, as well as a distal solenoid to enhance tip visibility on a loopless antenna. We tested different tip-solenoid configurations to balance heating and signal profiles. We tested mechanical performance in vitro and in vivo in comparison with a popular clinical nitinol guidewire. Results The solenoid displaced the point of maximal heating (“hot spot” from the tip to a more proximal location where it can be measured without impairing guidewire flexion. Probe pullback allowed creation of lengthwise guidewire temperature maps that allowed rapid evaluation of design prototypes. Distal-only solenoid attachment offered the best compromise between tip visibility and heating among design candidates. When fixed at the hot spot, the internal probe consistently reflected the maximum temperature compared external probes. Real-time temperature monitoring was performed during porcine left heart catheterization. Heating was negligible using normal operating parameters (flip angle, 45°; SAR, 1.01 W/kg; the temperature increased by 4.2°C only during high RF power mode (flip angle, 90°; SAR, 3.96 W/kg and only when the guidewire was isolated from blood cooling effects by an introducer sheath. The tip flexibility and in vivo performance of the final guidewire design were similar to a popular commercial guidewire. Conclusions We integrated a fiberoptic temperature probe inside

  15. MRI active guidewire with an embedded temperature probe and providing a distinct tip signal to enhance clinical safety.

    Science.gov (United States)

    Sonmez, Merdim; Saikus, Christina E; Bell, Jamie A; Franson, Dominique N; Halabi, Majdi; Faranesh, Anthony Z; Ozturk, Cengizhan; Lederman, Robert J; Kocaturk, Ozgur

    2012-06-21

    The field of interventional cardiovascular MRI is hampered by the unavailability of active guidewires that are both safe and conspicuous. Heating of conductive guidewires is difficult to predict in vivo and disruptive to measure using external probes. We describe a clinical-grade 0.035" (0.89 mm) guidewire for MRI right and left heart catheterization at 1.5 T that has an internal probe to monitor temperature in real-time, and that has both tip and shaft visibility as well as suitable flexibility. The design has an internal fiberoptic temperature probe, as well as a distal solenoid to enhance tip visibility on a loopless antenna. We tested different tip-solenoid configurations to balance heating and signal profiles. We tested mechanical performance in vitro and in vivo in comparison with a popular clinical nitinol guidewire. The solenoid displaced the point of maximal heating ("hot spot") from the tip to a more proximal location where it can be measured without impairing guidewire flexion. Probe pullback allowed creation of lengthwise guidewire temperature maps that allowed rapid evaluation of design prototypes. Distal-only solenoid attachment offered the best compromise between tip visibility and heating among design candidates. When fixed at the hot spot, the internal probe consistently reflected the maximum temperature compared external probes.Real-time temperature monitoring was performed during porcine left heart catheterization. Heating was negligible using normal operating parameters (flip angle, 45°; SAR, 1.01 W/kg); the temperature increased by 4.2°C only during high RF power mode (flip angle, 90°; SAR, 3.96 W/kg) and only when the guidewire was isolated from blood cooling effects by an introducer sheath. The tip flexibility and in vivo performance of the final guidewire design were similar to a popular commercial guidewire. We integrated a fiberoptic temperature probe inside a 0.035" MRI guidewire. Real-time monitoring helps detect deleterious

  16. EnViSoRS: Enhanced Vision System for Robotic Surgery. A User-Defined Safety Volume Tracking to Minimize the Risk of Intraoperative Bleeding

    Directory of Open Access Journals (Sweden)

    Veronica Penza

    2017-05-01

    Full Text Available In abdominal surgery, intraoperative bleeding is one of the major complications that affect the outcome of minimally invasive surgical procedures. One of the causes is attributed to accidental damages to arteries or veins, and one of the possible risk factors falls on the surgeon’s skills. This paper presents the development and application of an Enhanced Vision System for Robotic Surgery (EnViSoRS, based on a user-defined Safety Volume (SV tracking to minimize the risk of intraoperative bleeding. It aims at enhancing the surgeon’s capabilities by providing Augmented Reality (AR assistance toward the protection of vessels from injury during the execution of surgical procedures with a robot. The core of the framework consists in (i a hybrid tracking algorithm (LT-SAT tracker that robustly follows a user-defined Safety Area (SA in long term; (ii a dense soft tissue 3D reconstruction algorithm, necessary for the computation of the SV; (iii AR features for visualization of the SV to be protected and of a graphical gage indicating the current distance between the instruments and the reconstructed surface. EnViSoRS was integrated with a commercial robotic surgical system (the dVRK system for testing and validation. The experiments aimed at demonstrating the accuracy, robustness, performance, and usability of EnViSoRS during the execution of a simulated surgical task on a liver phantom. Results show an overall accuracy in accordance with surgical requirements (<5 mm, and high robustness in the computation of the SV in terms of precision and recall of its identification. The optimization strategy implemented to speed up the computational time is also described and evaluated, providing AR features update rate up to 4 fps, without impacting the real-time visualization of the stereo endoscopic video. Finally, qualitative results regarding the system usability indicate that the proposed system integrates well with the commercial surgical robot and

  17. Medical Device Safety

    Science.gov (United States)

    ... Communication Date FDA Warns Against Use of Injectable Silicone for Body Contouring and Enhancement: FDA Safety Communication ... 03/18/17 Neurovascular Thrombus Retrieval Catheters and Guide Catheters Used During Neurological Interventional Procedures: Differences in ...

  18. First Phase I human clinical trial of a killed whole-HIV-1 vaccine: demonstration of its safety and enhancement of anti-HIV antibody responses.

    Science.gov (United States)

    Choi, Eunsil; Michalski, Chad J; Choo, Seung Ho; Kim, Gyoung Nyoun; Banasikowska, Elizabeth; Lee, Sangkyun; Wu, Kunyu; An, Hwa-Yong; Mills, Anthony; Schneider, Stefan; Bredeek, U Fritz; Coulston, Daniel R; Ding, Shilei; Finzi, Andrés; Tian, Meijuan; Klein, Katja; Arts, Eric J; Mann, Jamie F S; Gao, Yong; Kang, C Yong

    2016-11-28

    Vaccination with inactivated (killed) whole-virus particles has been used to prevent a wide range of viral diseases. However, for an HIV vaccine this approach has been largely negated due to inherent safety concerns, despite the ability of killed whole-virus vaccines to generate a strong, predominantly antibody-mediated immune response in vivo. HIV-1 Clade B NL4-3 was genetically modified by deleting the nef and vpu genes and substituting the coding sequence for the Env signal peptide with that of honeybee melittin signal peptide to produce a less virulent and more replication efficient virus. This genetically modified virus (gmHIV-1NL4-3) was inactivated and formulated as a killed whole-HIV vaccine, and then used for a Phase I human clinical trial (Trial Registration: Clinical Trials NCT01546818). The gmHIV-1NL4-3 was propagated in the A3.01 human T cell line followed by virus purification and inactivation with aldrithiol-2 and γ-irradiation. Thirty-three HIV-1 positive volunteers receiving cART were recruited for this observer-blinded, placebo-controlled Phase I human clinical trial to assess the safety and immunogenicity. Genetically modified and killed whole-HIV-1 vaccine, SAV001, was well tolerated with no serious adverse events. HIV-1NL4-3-specific PCR showed neither evidence of vaccine virus replication in the vaccine virus-infected human T lymphocytes in vitro nor in the participating volunteers receiving SAV001 vaccine. Furthermore, SAV001 with adjuvant significantly increased the pre-existing antibody response to HIV-1 proteins. Antibodies in the plasma of vaccinees were also found to recognize HIV-1 envelope protein on the surface of infected cells as well as showing an enhancement of broadly neutralizing antibodies inhibiting tier I and II of HIV-1 B, D, and A subtypes. The killed whole-HIV vaccine, SAV001, is safe and triggers anti-HIV immune responses. It remains to be determined through an appropriate trial whether this immune response prevents HIV

  19. Reliability-Based and Cost-Oriented Product Optimization Integrating Fuzzy Reasoning Petri Nets, Interval Expert Evaluation and Cultural-Based DMOPSO Using Crowding Distance Sorting

    Directory of Open Access Journals (Sweden)

    Zhaoxi Hong

    2017-08-01

    Full Text Available In reliability-based and cost-oriented product optimization, the target product reliability is apportioned to subsystems or components to achieve the maximum reliability and minimum cost. Main challenges to conducting such optimization design lie in how to simultaneously consider subsystem division, uncertain evaluation provided by experts for essential factors, and dynamic propagation of product failure. To overcome these problems, a reliability-based and cost-oriented product optimization method integrating fuzzy reasoning Petri net (FRPN, interval expert evaluation and cultural-based dynamic multi-objective particle swarm optimization (DMOPSO using crowding distance sorting is proposed in this paper. Subsystem division is performed based on failure decoupling, and then subsystem weights are calculated with FRPN reflecting dynamic and uncertain failure propagation, as well as interval expert evaluation considering six essential factors. A mathematical model of reliability-based and cost-oriented product optimization is established, and the cultural-based DMOPSO with crowding distance sorting is utilized to obtain the optimized design scheme. The efficiency and effectiveness of the proposed method are demonstrated by the numerical example of the optimization design for a computer numerically controlled (CNC machine tool.

  20. Randomized Trials and Self-Reported Accident as a Method to Study Safety-Enhancing Measures for Cyclists - two case studies

    DEFF Research Database (Denmark)

    Lahrmann, Harry Spaabæk; Madsen, Tanja Kidholm Osmann; Olesen, Anne Vingaard

    2016-01-01

    In this paper we describe the safety impact of increased visibility of cyclists through two randomised controlled trials: permanent running lights on bicycles and a yellow bike jacket, respectively.......In this paper we describe the safety impact of increased visibility of cyclists through two randomised controlled trials: permanent running lights on bicycles and a yellow bike jacket, respectively....

  1. Organizational-Legal and Technological Aspects of Ensuring Environmental Safety of Mining Enterprises: Perspective Analysis in the Context of the General Enhancement of Environmental Problem

    Science.gov (United States)

    Vorontsova, Elena; Vorontsov, Andrey; Drozdenko, Yuriy

    2017-11-01

    The article is devoted to the analysis of problems of maintenance of ecological safety of the mining enterprises. The aim of the work was the formulation of proposals, the implementation of which, in the opinion of the authors, is capable of raising the level of environmental safety of the mining industry and ultimately ensuring the environmentally oriented growth of the Russian economy.

  2. A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10?mg plus permeation enhancer DDM, for the acute treatment of episodic migraine

    OpenAIRE

    Munjal, Sagar; Brand-Schieber, Elimor; Allenby, Kent; Spierings, Egilius L.H.; Cady, Roger K.; Rapoport, Alan M.

    2017-01-01

    Background DFN-02 is a novel intranasal spray formulation composed of sumatriptan 10?mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-?-D-Maltopyranoside (DDM). This composition of DFN-02 allows sumatriptan to be rapidly absorbed into the systemic circulation and exhibit pharmacokinetics comparable to subcutaneously administered sumatriptan. Rapid rate of absorption is suggested to be important for optimal efficacy. The objective of this study was to evaluate the safety...

  3. A Randomized Trial Comparing the Pharmacokinetics, Safety, and Tolerability of DFN-02, an Intranasal Sumatriptan Spray Containing a Permeation Enhancer, With Intranasal and Subcutaneous Sumatriptan in Healthy Adults.

    Science.gov (United States)

    Munjal, Sagar; Gautam, Anirudh; Offman, Elliot; Brand-Schieber, Elimor; Allenby, Kent; Fisher, Dennis M

    2016-10-01

    Intranasal sumatriptan (Imitrex® ) may be an alternative for patients who refuse injections and cannot tolerate oral agents, but due to low bioavailability and slow absorption, the clinical utility of the currently marketed formulation is limited, highlighting an unmet need for an effective non-oral migraine medication with a rapid onset of action. To overcome the slow absorption profile associated with intranasal administration, we evaluated the impact of 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM, Intravail A-3™), a permeation enhancer, on sumatriptan's pharmacokinetic profile by comparing the pharmacokinetic characteristics of two commercial sumatriptan products, 4 mg subcutaneous and 6 mg subcutaneous in healthy adults, with DFN-02 - a novel intranasal agent comprised of sumatriptan 10 mg plus 0.20% DDM. We also determined the pharmacokinetic characteristics of DDM and evaluated its safety and tolerability. We conducted two studies: a randomized, three-way crossover study comparing monodose and multidose devices for delivery of single doses of DFN-02 with commercially available intranasal sumatriptan 20 mg in 18 healthy, fasted adults, and an open-label, randomized, single-dose, three-way crossover bioavailability study comparing DFN-02 with 4 mg and 6 mg subcutaneous sumatriptan in 78 healthy, fasted adults. In the study comparing DFN-02 with IN sumatriptan, subjects received a single dose of DFN-02 (sumatriptan 10 mg plus DDM 0.20%) via monodose and multidose delivery systems with at least 5 days between treatments. In the comparison with SC sumatriptan, subjects received a single dose of each treatment with at least 3 days between treatments. In both studies, blood was sampled for pharmacokinetic evaluation of sumatriptan and DDM through 24 hours post-dose; safety and tolerability were monitored throughout. In the comparison with commercially available intranasal sumatriptan 20 mg, DFN-02 had a more rapid absorption profile; tmax was 15 minutes for DFN-02

  4. Drug Safety

    Science.gov (United States)

    ... over-the-counter drug. The FDA evaluates the safety of a drug by looking at Side effects ... clinical trials The FDA also monitors a drug's safety after approval. For you, drug safety means buying ...

  5. Synthesis and evaluation of sodium deoxycholate sulfate as a lipid drug carrier to enhance the solubility, stability and safety of an amphotericin B inhalation formulation.

    Science.gov (United States)

    Gangadhar, Katkam N; Adhikari, Kajiram; Srichana, Teerapol

    2014-08-25

    Amphotericin B (AmB) is still used as the gold standard for therapy against invasive fungal diseases. However, the use of AmB through oral administration is restricted due to its low solubility and stability in aqueous solution, which is the cause for its poor bioavailability and highly varying absorption. Therefore, an attempt has been made to enhance the solubility and stability of AmB to evaluate its bioactivity and safety for use as an inhaler by using a new excipient sodium deoxycholate sulfate (SDS) with aim of using it as a drug carrier for AmB. Therefore, SDS was formulated together with AmB as a dry powder by lyophilization. The dry powder was reconstituted in distilled water and evaluated its physicochemical properties such as zeta potential, particle size and pH to compare its solubility and stability of the formulations with a SDC-AmB (i.e., known as Fungizone(®)). In vitro toxicity studies were carried out with red blood cells (RBC) and respiratory cell lines. Bioactivity was determined by a micro-dilution method against Candidaalbicans and Cryptococcusneoformans. We found that SDS-AmB had a zeta potential (-45.53 mV), which was higher than of Fungizone(®); and produced a stable particle size in solution (73.8 nm). The particle size distributions of both formulations were expressed as their mass median aerodynamic diameters (MMAD; 1.70 and 1.74 μm), their fine particle fractions (FPF; 70 and 80%) and geometric standard deviations (GSD; 2.3 and 2.0), respectively. These values indicated that the sizes were appropriate for use in an inhaler. Pure AmB was found to hemolyse RBC and was very toxic to alveolar macrophage cells, as their viability rapidly declined from 93 to 56% when the AmB concentration increased from 1 to 8 μg/mL. The SDS-AmB formulation had a significantly reduced toxicity compared to AmB. The results clearly indicated that the SDS-lipid based nanoparticles had the potential to be used as an alternative option to Fungizone(®) for an

  6. Reliability Analysis and Calibration of Partial Safety Factors for Redundant Structures

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard

    1998-01-01

    be included in the safety system and how partial safety factors can be calibrated. An example is presented illustrating how redundancy is taken into account in the safety system in e.g. the Danish codes. The example shows how partial safety factors can be calibrated to comply with the safety level......Redundancy is important to include in the design and analysis of structural systems. In most codes of practice redundancy is not directly taken into account. In the paper various definitions of a deterministic and reliability based redundancy measure are reviewed. It is described how reundancy can...

  7. Nuclear safety in perspective

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, K. [Karinta-Konsult HB (Sweden); Sjoeberg, B.M.D. [Norwegian Univ. of Scince and Technology (Norway); Larudisen, K. [Risoe National Lab., Roskilde (Denmark); Wahlstroem, B. [VTT Automation (Finland)

    2002-06-01

    The aim of the NKS/SOS-1 project has been to enhance common understanding about requirements for nuclear safety by finding improved means of communicating on the subject in society. The project, which has been built around a number of seminars, was supported by limited research in three sub-projects: 1) Risk assessment, 2) Safety analysis, and 3) Strategies for safety management. The report describes an industry in change due to societal factors. The concepts of risk and safety, safety management and systems for regulatory oversight are described in the nuclear area and also, to widen the perspective, for other industrial areas. Transparency and public participation are described as key elements in good risk communication, and case studies are given. Environmental Impact Assessment and Strategic Environmental Assessment are described as important overall processes within which risk communication can take place. Safety culture, safety indicators and quality systems are important concepts in the nuclear safety area are very useful, but also offer important challenges for the future. They have been subject to special attention in the project. (au)

  8. Traffic enforcement in Europe: effects, measures, needs and future. Final report of the ESCAPE Consortium. (The acroynm ESCAPE stands for Enhanced Safety Coming from Appropriate Police Enforcement).

    NARCIS (Netherlands)

    Mäkinen, T. Zaidel, D.M. Andersson, G. Biecheler-Fretel, M.-B. Christ, R. Cauzard, J.-P. Elvik, R. Goldenbeld, C. Gelau, C. Heidstra, J. Jayet, M.-C. Nilsson, G. Papaioanou, P. Quimby, A. Rehnova, V. & Vaa, T.

    2003-01-01

    The objectives of the project were to identify important issues of traffic law enforcement in the EU, examine traditional and innovative enforcement approaches and tools, and assess their potential to improve compliance for increased safety on roads. The following main issues were addressed: the

  9. Auto Safety

    Science.gov (United States)

    ... to Talk to Your Child About the News Gun Safety Too Late for the Flu Vaccine? Eating ... many local health departments, public safety groups, hospitals, law enforcement agencies, and fire departments have technicians or ...

  10. Water Safety

    Science.gov (United States)

    ... School Counselors Kidney Stones Brain and Nervous System Water Safety KidsHealth > For Teens > Water Safety Print A ... tied to alcohol use. previous continue At the Water Park OK, so you do more splashing than ...

  11. Safety Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Swan Lake National Wildlife Refuge Safety Plan discusses policies for the safety of the station employees, volunteers, and public. This plan seeks to identify...

  12. Water Safety

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Water Safety KidsHealth / For Parents / Water Safety What's in ... remains your best measure of protection. Making Kids Water Wise It's important to teach your kids proper ...

  13. Fire safety

    Science.gov (United States)

    Robert H. White; Mark A. Dietenberger

    1999-01-01

    Fire safety is an important concern in all types of construction. The high level of national concern for fire safety is reflected in limitations and design requirements in building codes. These code requirements are discussed in the context of fire safety design and evaluation in the initial section of this chapter. Since basic data on fire behavior of wood products...

  14. Section IV.D.3 for DOE 2013 Annual Report: Novel Phosphazene-based Compounds to Enhance Safety and Stability of Cell Chemistries for High Voltage Applications (INL)

    Energy Technology Data Exchange (ETDEWEB)

    Gering, Kevin L. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Harrup, Mason K. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Dufek, Eric J. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sazhin, Sergiy V. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Rollins, Harry W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Jamison, David K. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Stewart, Fred F. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Burba, John [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2013-09-01

    Electrolytes play a central role in performance and aging in most electrochemical systems. As automotive and grid applications place a higher reliance on electrochemical stored energy, it becomes more urgent to have electrolyte components that enable optimal battery performance while promoting battery safety and longevity. Safety remains a foremost concern for widespread utilization of Li-ion technology in electric-drive vehicles, especially as the focus turns to higher voltage systems (5V). This work capitalizes on the long established INL expertise regarding phosphazene chemistry, aimed at battery-viable compounds for electrolytes and electrodes that are highly tolerant to abusive conditions. This report showcases our 2013 work for the DOE applied battery research (ABR) program, wherein testing results are summarized for INL electrolytes and alternative anode materials.

  15. Safety Training: Basic safety courses

    CERN Document Server

    Laetitia Laddada

    2004-01-01

    Safety Training: Basic safety courses Due to the 50th anniversary events, basic safety courses are cancelled  during  week 43. We remind that in general, courses take place each Tuesday morning in French and Tuesday afternoon in English in Bdg.65-1-003. The duration of the course is 1h30. There are two half day sessions: 9 a.m. and 11 a.m. in French, and 2 p.m. and 4 p.m. in English. Thanks for your  understanding.  SC-DI FORMATION EN SECURITE SAFETY TRAINING Laetitia Laddada 73811 - 79236 safety.training@cern.ch

  16. Moving forward with safety culture.

    Science.gov (United States)

    Weber, Michael

    2012-04-01

    Radiation safety and protection of people are shared goals of the Health Physics Society (HPS) and the U.S. Nuclear Regulatory Commission (NRC). A positive safety culture contributes to achieving radiation safety and protection of people, which are important to both the HPS and the NRC. Through unprecedented collaboration and engagement with diverse stakeholders, the NRC and the stakeholders developed a Safety Culture Policy Statement. The policy statement defines safety culture and describes the traits of a positive safety culture. Consideration of both safety and security issues and the interface of safety and security are underlying principles that support the policy. Examination of significant events, both within the nuclear industry and in society at large, illustrates how weaknesses in these traits can contribute to the occurrence and consequences of safety incidents, including serious injury and loss of life. With the policy statement in place, the NRC is moving forward with outreach and education about safety culture. Health physicists and other radiation safety specialists play an essential role in enhancing safety culture.

  17. Development of a lateral-flow assay for rapid screening of the performance-enhancing sympathomimetic drug clenbuterol used in animal production; food safety assessments.

    Science.gov (United States)

    Lai, Weihua; Xu, Yang; Fung, Daniel Y C; Xiong, Yonghua

    2007-01-01

    A lateral-flow assay that could provide visual evidence of the presence of clenbuterol in swine urine was developed. Colloidal gold was prepared and conjugated with anti-clenbuterol monoclonal antibody. Immunochromatographic test strips were produced, and then, 210 samples were tested on these strips. Analysis was completed in 10 min. Detection limit was 3 ppb of clenbuterol. Parallel GC-MS data indicated that clenbuterol rapid detection strip had no false negative. The false positive rate was 4.4%. Immunochromatographic strip has great applied value in the food safety field because it possesses benefits of sensitivity, stability, reproducibility, ease of use and inexpensive.

  18. Safety; Avertissement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This annual report of the Senior Inspector for the Nuclear Safety, analyses the nuclear safety at EDF for the year 1999 and proposes twelve subjects of consideration to progress. Five technical documents are also provided and discussed concerning the nuclear power plants maintenance and safety (thermal fatigue, vibration fatigue, assisted control and instrumentation of the N4 bearing, 1300 MW reactors containment and time of life of power plants). (A.L.B.)

  19. Visit safety

    CERN Multimedia

    2012-01-01

    Experiment areas, offices, workshops: it is possible to have co-workers or friends visit these places.     You already know about the official visits service, the VIP office, and professional visits. But do you know about the safety instruction GSI-OHS1, “Visits on the CERN site”? This is a mandatory General Safety Instruction that was created to assist you in ensuring safety for all your visits, whatever their nature—especially those that are non-official. Questions? The HSE Unit will be happy to answer them. Write to safety-general@cern.ch.   The HSE Unit

  20. Fuel Fracture (Crumbling) Safety Impact (OCRWM)

    Energy Technology Data Exchange (ETDEWEB)

    DUNCAN, D.R.

    1999-12-08

    The safety impact of experimentally observed N Reactor fuel sample fracture and fragmentation is evaluated using an average reaction rate enhancement derived from data from thermo-gravimetric analysis (TGA) experiments on fuel samples. The enhanced reaction rates attributed to fragmentation were within the existing safety basis.

  1. Adequacy and safety of an infant formula with a protein/energy ratio of 1.8 g/100 kcal and enhanced protein efficiency for term infants during the first 4 months of life.

    Science.gov (United States)

    Turck, Dominique; Grillon, Christophe; Lachambre, Emmanuelle; Robiliard, Patrick; Beck, Laurence; Maurin, Jean-Luc; Kempf, Christian; Bernet, Jean-Paul; Marx, Jacques; Lebrun, Françoise; Van Egroo, Louis-Dominique

    2006-09-01

    Excess protein in infant formula may lead to renal overload and play a role in later obesity. The objective of this controlled, prospective, randomized, double-blind study was to assess the suitability and safety of a modified protein content infant formula and its noninferiority as compared to a conventional formula. Healthy term infants age energy ratio: 2.6 g/100 kcal) or the isocaloric whey-predominant study formula (protein/energy ratio: 1.8 g/100 kcal) for 120 days. Primary outcome was daily weight gain between D0 and D120 (noninferiority criterion: difference in daily weight gain index at monthly intervals. Tolerance and safety were assessed at each visit. 162 infants were enrolled, 84% of the formula-fed infants and 36% of the breast-fed infants completing the study. Mean daily weight gain from D0 to D120 in the formula-fed groups differed by 0.38 g/day [95% CI: -2.59; 1.83] signifying the noninferiority of the study formula. Secondary outcomes did not differ between the 2 groups at any time and were comparable to outcomes in the breast-fed group. Tolerance was good and adverse events were not different between study groups. The whey-predominant study infant formula with a protein/energy ratio of 1.8 g/100 kcal and enhanced protein efficiency is safe and not inferior to a conventional formula in ensuring normal growth during the first four months of life.

  2. Introduction of a Team Based Approach to Radiation Dose Reduction in the Enhancement of the Overall Radiation Safety Profile of FEVAR.

    Science.gov (United States)

    Rolls, A E; Rosen, S; Constantinou, J; Davis, M; Cole, J; Desai, M; Stoyanov, D; Mastracci, T M

    2016-10-01

    Fenestrated endovascular aneurysm repair (FEVAR) exposes operators and patients to considerable amounts of radiation. Introduction of fusion of three-dimensional (3D) computed tomography (CT) with intraoperative fluoroscopy puts new focus on advanced imaging techniques in the operating environment and has been found to reduce radiation and facilitate faster repair. The aim of this study is to evaluate the radiation dose effect of introducing a team-based approach to complex aortic repair. Procedural details for a cohort of 21 patients undergoing FEVAR after fusion-guided (Modern Group) imaging was introduced are compared with 21 patients treated in the immediate 12 months prior to implementation (Historic Group) at a centre with expertise in FEVAR. Non-parametric tests were used to compare procedure time (PT), air kerma, dose-area product (DAP), fluoroscopy time (FT), estimated blood loss (EBL) and pre- and post-operative estimated glomerular filtration rate (eGFR) between the groups. Change in operative approach resulted in a significant reduction in PT for the Modern group (median 285 mins; interquartile range 268-322) compared with the Historic group (450 mins; IQR 360-540 p = <0.001). There were reductions in skin dose for the Modern group (1.6 Gy; IQR 1.09-2.1) compared with the Historic group (4.4 Gy; 3.2-7.05 p = <0.001), and DAP (Modern 159 Gy.cm2; IQR 123-226 vs 264.93 Gy.cm2; 173.3-366.8 for Historic (p = 0.006). There were no significant differences in FT, and pre- and post-operative eGFR between the two groups. Weight and height were distributed equally across both groups. Structured dose reports including the changes in frame rate were not available for analysis. Implementation of a team-based approach to radiation reduction significantly reduces radiation dose. These findings suggest that the radiation safety awareness that accompanies the introduction of fusion imaging may improve the overall radiation safety profile of FEVAR for patients

  3. Nuclear Safety

    Energy Technology Data Exchange (ETDEWEB)

    Silver, E G [ed.

    1989-01-01

    This document is a review journal that covers significant developments in the field of nuclear safety. Its scope includes the analysis and control of hazards associated with nuclear energy, operations involving fissionable materials, and the products of nuclear fission and their effects on the environment. Primary emphasis is on safety in reactor design, construction, and operation; however, the safety aspects of the entire fuel cycle, including fuel fabrication, spent-fuel processing, nuclear waste disposal, handling of radioisotopes, and environmental effects of these operations, are also treated.

  4. Vaccine Safety

    Science.gov (United States)

    ... Search Form Controls Cancel Submit Search The CDC Vaccine Safety Note: Javascript is disabled or is not ... CDC.gov . Recommend on Facebook Tweet Share Compartir Vaccine Adverse Events Reporting System (VAERS) New website and ...

  5. Food safety

    Science.gov (United States)

    Poor food safety practices can lead to foodborne illness. Symptoms of foodborne illnesses vary. They usually include stomach problems or stomach upset. Foodborne illnesses may be severe and fatal. Young children, older ...

  6. Randomized trials and self-reported accidents as a method to study safety-enhancing measures for cyclists-two case studies.

    Science.gov (United States)

    Lahrmann, Harry; Madsen, Tanja Kidholm Osmann; Olesen, Anne Vingaard

    2017-08-01

    A large number of studies show that high visibility in traffic is important in the struggle of getting the attention from other road users and thus an important safety factor. Cyclists have a much higher risk of being killed or injured in a traffic accident than car drivers so for them high visibility is particularly important. A number of studies have examined the effect of high visibility, such as reflective clothing, but most studies have been primitive, the data limited and the results very uncertain. In this paper we describe the safety impact of increased visibility of cyclists through two randomised controlled trials: permanent running lights on bicycles and a yellow bicycle jacket, respectively. The effect of running lights was studied through a trial where the lights were mounted to 1,845 bicycles and 2,000 others comprised a control group. The bicycle accidents were recorded every two month in a year through self-reporting on the Internet. Participants were asked to report all cycling accidents independently of severity to avoid differences between participants as regards to which accidents were reported. They reported a total of 255 accidents i.e. 7 accidents per 100 cyclists. The results showed that the incidence rate for multiparty bicycle accidents with personal injury was 47% lower for cyclists with permanent running light. The difference is statistically significant at the 5% level. The effect of a yellow bicycle jacket was examined through a trial with 6,800 volunteer cyclists. The half of the group received a bicycle jacket and the other half comprised a control group. Both groups reported every month all their bicycle accidents independently of severity on the Internet. They reported a total of 694 accidents i.e. 10 accidents per 100 cyclists. The treatment group was asked each month if they carried the jacket on their last cycling trip. The results showed that on a random day the treatment group carried the jacket or other fluorescent cycling

  7. Suicide gene approach using a dual-expression lentiviral vector to enhance the safety of ex vivo gene therapy for bone repair.

    Science.gov (United States)

    Alaee, F; Sugiyama, O; Virk, M S; Tang, H; Drissi, H; Lichtler, A C; Lieberman, J R

    2014-02-01

    'Ex vivo' gene therapy using viral vectors to overexpress BMP-2 is shown to heal critical-sized bone defects in experimental animals. To increase its safety, we constructed a dual-expression lentiviral vector to overexpress BMP-2 or luciferase and an HSV1-tk analog, Δtk (LV-Δtk-T2A-BMP-2/Luc). We hypothesized that administering ganciclovir (GCV) will eliminate the transduced cells at the site of implantation. The vector-induced expression of BMP-2 and luciferase in a mouse stromal cell line (W-20-17 cells) and mouse bone marrow cells (MBMCs) was reduced by 50% compared with the single-gene vector. W-20-17 cells were more sensitive to GCV compared with MBMCs (90-95% cell death at 12 days with GCV at 1 μg ml(-1) in MBMCs vs 90-95% cell death at 5 days by 0.1 μg ml(-1) of GCV in W-20-17 cells). Implantation of LV-Δtk-T2A-BMP-2 transduced MBMCs healed a 2 mm femoral defect at 4 weeks. Early GCV treatment (days 0-14) postoperatively blocked bone formation confirming a biologic response. Delayed GCV treatment starting at day 14 for 2 or 4 weeks reduced the luciferase signal from LV-Δtk-T2A-Luc-transduced MBMCs, but the signal was not completely eliminated. These data suggest that this suicide gene strategy has potential for clinical use in the future, but will need to be optimized for increased efficiency.

  8. Robots' Safety

    OpenAIRE

    Pirttilahti, Juho

    2016-01-01

    Human-robot-collaboration is considered one of the answers to the flexible needs of more and more customizing manufacturing. Its purpose is to fit together the best qualities of both human and robots to reduce the cost and time of manufacturing. One of the key questions in this area is safety. The purpose of this thesis was to define the required safety functionality of cartesian, delta and articulated robots based on the current machine needs. Using the future robotic concepts investigat...

  9. Nuclear safety research master plan

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Jae Joo; Yang, J. U.; Jun, Y. S. and others

    2001-06-01

    The SRMP (Safety Research Master Plan) is established to cope with the changes of nuclear industry environments. The tech. tree is developed according to the accident progress of the nuclear reactor. The 11 research fields are derived to cover the necessary technologies to ensure the safety of nuclear reactors. Based on the developed tech. tree, the following four main research fields are derived as the main safety research areas: 1. Integrated nuclear safety enhancement, 2. Thermal hydraulic experiment and assessment, 3. Severe accident management and experiment, and 4. The integrity of equipment and structure. The research frame and strategies are also recommended to enhance the efficiency of research activity, and to extend the applicability of research output.

  10. Application of Neutron-Absorbing Structural-Amorphous Metal (SAM) Coatings for Spent Nuclear Fuel (SNF) Container to Enhance Criticality Safety Controls

    Energy Technology Data Exchange (ETDEWEB)

    Choi, J; Lee, C; Day, D; Wall, M; Saw, C; MoberlyChan, W; Farmer, J; Boussoufl, M; Liu, B; Egbert, H; Branagan, D; D' Amato, A

    2006-11-13

    Spent nuclear fuel contains fissionable materials ({sup 235}U, {sup 239}Pu, {sup 241}Pu, etc.). Neutron multiplication and the potential for criticality are enhanced by the presence of a moderator during cask loading in water, water incursion in accidents conditions during spent fuel storage or transport. To prevent nuclear criticality in spent fuel storage, transportation, and during disposal, neutron-absorbing materials (or neutron poisons, such as borated stainless steel, Boral{trademark}, Metamic{trademark}, Ni-Gd, and others) would have to be applied. The success in demonstrating that the High-Performance Corrosion-Resistant material (HPCRM) can be thermally applied as coating onto base metal to provide for corrosion resistance for many naval applications raises the interest in applying the HPCRM to USDOE/OCRWM spent fuel management program. The fact that the HPCRM relies on the high content of boron to make the material amorphous--an essential property for corrosion resistance--and that the boron has to be homogeneously distributed in the HPCRM qualify the material to be a neutron poison.

  11. Impact of e-safety applications on cyclists' safety.

    Science.gov (United States)

    Tripodi, Antonino; Persia, Luca

    2015-01-01

    In years to come, urban areas face the challenge of making transport sustainable in terms of environment and competitiveness. Cycling is a perfect transport means in urban areas. Cyclists have a high casualty rate and should be given special attention in road safety policy. Actions to promote cycling in cities should go together with improving road safety. ICT can be used to develop intelligent applications assisting cyclists to avoid, prevent or mitigate accidents. This paper presents the results of activities focused on the assessment of impacts of ICT on the safety of cyclists, realised in the framework of the EU project SAFECYCLE ( www.safecycle.eu ). E-safety applications were identified that can enhance the safety of cyclists in Europe. Eleven applications were analysed in term of benefits and costs. The results highlighted important differences between European countries in term of awareness about cycling, knowledge about ICT applications and also impacts of these applications.

  12. SAFETY INSTRUCTION AND SAFETY NOTE

    CERN Multimedia

    TIS Secretariat

    2002-01-01

    Please note that the SAFETY INSTRUCTION N0 49 (IS 49) and the SAFETY NOTE N0 28 (NS 28) entitled respectively 'AVOIDING CHEMICAL POLLUTION OF WATER' and 'CERN EXHIBITIONS - FIRE PRECAUTIONS' are available on the web at the following urls: http://edms.cern.ch/document/335814 and http://edms.cern.ch/document/335861 Paper copies can also be obtained from the TIS Divisional Secretariat, email: TIS.Secretariat@cern.ch

  13. System safety education focused on flight safety

    Science.gov (United States)

    Holt, E.

    1971-01-01

    The measures necessary for achieving higher levels of system safety are analyzed with an eye toward maintaining the combat capability of the Air Force. Several education courses were provided for personnel involved in safety management. Data include: (1) Flight Safety Officer Course, (2) Advanced Safety Program Management, (3) Fundamentals of System Safety, and (4) Quantitative Methods of Safety Analysis.

  14. KHNP Safety Culture Framework based on Global Standard, and Lessons learned from Safety Culture Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Younggab; Hur, Nam Young; Jeong, Hyeon Jong [KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    In order to eliminate the vague fears of the people about the nuclear power and operate continuously NPPs, a strong safety culture of NPPs should be demonstrated. Strong safety culture awareness of workers can overcome social distrust about NPPs. KHNP has been a variety efforts to improve and establish safety culture of NPPs. Safety culture framework applying global standards was set up and safety culture assessment has been carried out periodically to enhance safety culture of workers. In addition, KHNP developed various safety culture contents and they are being used in NPPs by workers. As a result of these efforts, safety culture awareness of workers is changed positively and the safety environment of NPPs is expected to be improved. KHNP makes an effort to solve areas for improvement derived from safety culture assessment. However, there are some areas to take a long time in completing the work. Therefore, these actions are necessary to be carried out consistently and continuously. KHNP also developed recently safety culture enhancement system based on web. All information related to safety culture in KHNP will be shared through this web system and this system will be used to safety culture assessment. In addition to, KHNP plans to develop safety culture indicators for monitoring the symptoms of safety culture weakening.

  15. Patient safety culture among nurses.

    Science.gov (United States)

    Ammouri, A A; Tailakh, A K; Muliira, J K; Geethakrishnan, R; Al Kindi, S N

    2015-03-01

    Patient safety is considered to be crucial to healthcare quality and is one of the major parameters monitored by all healthcare organizations around the world. Nurses play a vital role in maintaining and promoting patient safety due to the nature of their work. The purpose of this study was to investigate nurses' perceptions about patient safety culture and to identify the factors that need to be emphasized in order to develop and maintain the culture of safety among nurses in Oman. A descriptive and cross-sectional design was used. Patient safety culture was assessed by using the Hospital Survey on Patient Safety Culture among 414 registered nurses working in four major governmental hospitals in Oman. Descriptive statistics and general linear regression were employed to assess the association between patient safety culture and demographic variables. Nurses who perceived more supervisor or manager expectations, feedback and communications about errors, teamwork across hospital units, and hospital handoffs and transitions had more overall perception of patient safety. Nurses who perceived more teamwork within units and more feedback and communications about errors had more frequency of events reported. Furthermore, nurses who had more years of experience and were working in teaching hospitals had more perception of patient safety culture. Learning and continuous improvement, hospital management support, supervisor/manager expectations, feedback and communications about error, teamwork, hospital handoffs and transitions were found to be major patient safety culture predictors. Investing in practices and systems that focus on improving these aspects is likely to enhance the culture of patient safety in Omani hospitals and others like them. Strategies to nurture patient safety culture in Omani hospitals should focus upon building leadership capacity that support open communication, blame free, team work and continuous organizational learning. © 2014 International

  16. Playground Safety.

    Science.gov (United States)

    Sipes, James L.

    2000-01-01

    Discusses the issues of risk, liability, and fun when landscaping playgrounds with safety in mind. The importance of playground surfaces and several preventive measures landscapers can use to reduce the risk of injury are discussed. Concluding comments address playground design features and liability. (GR)

  17. Safety Resources.

    Science.gov (United States)

    Hoot, James L.; Bartkowiak, Elaine T.

    1994-01-01

    Lists 72 organizations and programs that deal with child safety, grouped by the following categories: (1) general; (2) general violence; (3) gun violence; (4) media violence; (5) drugs and alcohol; (6) child abuse and at-risk children; (7) parenting programs; (8) community service programs; (9) leadership programs; (10) peer counseling; (11)…

  18. Patient safety

    African Journals Online (AJOL)

    medical error and patient harm. The patient safety movement is now 13 years old, led by the publication of the US. Institute of Medicine (IOM) Report To Err is Human.1 The basic premise at the time was that annually up to 98 000 Americans were estimated to have died because of medical error (although this calculation.

  19. A literature review of safety culture.

    Energy Technology Data Exchange (ETDEWEB)

    Cole, Kerstan Suzanne; Stevens-Adams, Susan Marie; Wenner, Caren A.

    2013-03-01

    Workplace safety has been historically neglected by organizations in order to enhance profitability. Over the past 30 years, safety concerns and attention to safety have increased due to a series of disastrous events occurring across many different industries (e.g., Chernobyl, Upper Big-Branch Mine, Davis-Besse etc.). Many organizations have focused on promoting a healthy safety culture as a way to understand past incidents, and to prevent future disasters. There is an extensive academic literature devoted to safety culture, and the Department of Energy has also published a significant number of documents related to safety culture. The purpose of the current endeavor was to conduct a review of the safety culture literature in order to understand definitions, methodologies, models, and successful interventions for improving safety culture. After reviewing the literature, we observed four emerging themes. First, it was apparent that although safety culture is a valuable construct, it has some inherent weaknesses. For example, there is no common definition of safety culture and no standard way for assessing the construct. Second, it is apparent that researchers know how to measure particular components of safety culture, with specific focus on individual and organizational factors. Such existing methodologies can be leveraged for future assessments. Third, based on the published literature, the relationship between safety culture and performance is tenuous at best. There are few empirical studies that examine the relationship between safety culture and safety performance metrics. Further, most of these studies do not include a description of the implementation of interventions to improve safety culture, or do not measure the effect of these interventions on safety culture or performance. Fourth, safety culture is best viewed as a dynamic, multi-faceted overall system composed of individual, engineered and organizational models. By addressing all three components of

  20. Comprehensive Lifecycle for Assuring System Safety

    Science.gov (United States)

    Knight, John C.; Rowanhill, Jonathan C.

    2017-01-01

    CLASS is a novel approach to the enhancement of system safety in which the system safety case becomes the focus of safety engineering throughout the system lifecycle. CLASS also expands the role of the safety case across all phases of the system's lifetime, from concept formation to decommissioning. As CLASS has been developed, the concept has been generalized to a more comprehensive notion of assurance becoming the driving goal, where safety is an important special case. This report summarizes major aspects of CLASS and contains a bibliography of papers that provide additional details.

  1. IMPORTANCE OF SAFETY CULTURE ASSESSMENT

    Energy Technology Data Exchange (ETDEWEB)

    Spitalnik, J.

    2004-10-06

    Safety Management has lately been considered by some Nuclear Regulatory agencies as the tool on which to concentrate their efforts to implement modern regulation structures, because Safety Culture was said to be difficult to monitor. However, Safety Culture can be assessed and monitored even if it is problematical to make Safety Culture the object of regulation. This paper stresses the feasibility and importance of Safety Culture Assessment based on self-assessment applications performed in several nuclear organizations in Latin America. Reasons and ownership for assessing Safety Culture are discussed, and relevant aspects considered for setting up and programming such an assessment are shown. Basic principles that were taken into account, as well as financial and human resources used in actual self-assessments are reviewed, including the importance of adequate statistical analyses and the necessity of proper feed-back of results. The setting up of action plans to enhance Safety Culture is the final step of the assessment program that once implemented will enable to establish a Safety Culture monitoring process within the organization.

  2. Clinicians, librarians and patient safety: opportunities for partnership.

    Science.gov (United States)

    Zipperer, L

    2004-06-01

    Librarians could improve the safety of medical care through greater participation in patient safety initiatives. A librarian's expertise in accessing the evidence base could enhance the safety and appropriateness of care in a clinical environment. In addition, librarians could apply specific technical knowledge management skills to medicine. To realize improvements from these skill sets, healthcare leaders must consider ways of working with librarians to enhance patient safety.

  3. Safety Note

    CERN Multimedia

    SC Secretariat

    2004-01-01

    Please note that the Safety Note no 29 (NS 29) entitled 'Fire Prevention for Insulating Core (Sandwich) Panel Structures for Inside Use Guidelines for Selection, Installation and Use' is available on the web at the following url: https://edms.cern.ch/document/475438/LAST_RELEASED Paper copies can also be obtained from the SC Unit secretariat, e-mail : sc.secretariat@cern.ch SC Secretariat

  4. Road.safety.forum - Integrated safety concepts and reliability. Proceedings; verkehrs.sicherheits.forum - Integrierte Sicherheitskonzepte und Zuverlaessigkeit. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    The proceedings volume of the two days Meeting titled:''road.safety.forum - Integrated Safety Concepts and Reliability'' which has been held on the 5th and 6th April 2005 in Leipzig, includes the ten contributions presented. The subjects were as follows: safety and reliability in modern vehicles; e-safty activities of European Commission; advanced safety technology for enhanced road safety; safety systems - sometimes less may be more - analysis related to markets with limited purchasing power like in Czech Republic; modern design of the truck driver's workplace and supporting technologies for road safety; risk management and car safety; concepts of driver assistance - state of affairs and outlook; to err (while driving) is human - which technical systems can help?; Safety Net: developing the European Road Safety Observatory; consumer safety ratings and their effect on car safety. The manuscripts are available in the form of reproduced overhead foils. (AKF)

  5. Nuclear safety

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-07-01

    The Program on Nuclear Safety comprehends Radioprotection, Radioactive Waste Management and Nuclear Material Control. These activities are developed at the Nuclear Safety Directory. The Radioactive Waste Management Department (GRR) was formally created in 1983, to promote research and development, teaching and service activities in the field of radioactive waste. Its mission is to develop and employ technologies to manage safely the radioactive wastes generated at IPEN and at its customer’s facilities all over the country, in order to protect the health and the environment of today's and future generations. The Radioprotection Service (GRP) aims primarily to establish requirements for the protection of people, as workers, contractors, students, members of the general public and the environment from harmful effects of ionizing radiation. Furthermore, it also aims to establish the primary criteria for the safety of radiation sources at IPEN and planning and preparing for response to nuclear and radiological emergencies. The procedures about the management and the control of exposures to ionizing radiation are in compliance with national standards and international recommendations. Research related to the main activities is also performed. The Nuclear Material Control has been performed by the Safeguard Service team, which manages the accountability and the control of nuclear material at IPEN facilities and provides information related to these activities to ABACC and IAEA. (author)

  6. 76 FR 46149 - Financial Assistance: Wildlife Restoration, Sport Fish Restoration, Hunter Education and Safety

    Science.gov (United States)

    2011-08-01

    ... Assistance: Wildlife Restoration, Sport Fish Restoration, Hunter Education and Safety; Final Rule #0;#0... Restoration, Sport Fish Restoration, and Hunter Education and Safety (Enhanced Hunter Education and Safety... Enhanced Hunter Education and Safety program; and (d) receive financial assistance from the Sport Fish...

  7. Guidelines for engineering design for process safety

    National Research Council Canada - National Science Library

    2012-01-01

    .... Key areas to be enhanced in the new edition include inherently safer design, specifically concepts for design of inherently safer unit operations and Safety Instrumented Systems and Layer of Protection Analysis...

  8. Clinical risk management: enhancing patient safety.

    OpenAIRE

    Ruggiero Perrino, Nunzia

    2001-01-01

    Risk Management was in the beginning primarily considered a means of controlling and managing litigation, which has been the major worry for clinicians in many countries for a considerable time and a growing problem in the international context. Early risk management strategies were dominated by attempts to reform the legal system and reduce the levels of compensation and the associated costs (Mills, 1995). Gradually...

  9. Enhancing agent safety through autonomous environment adaptation

    CSIR Research Space (South Africa)

    Rosman, Benjamin S

    2015-08-01

    Full Text Available ). Another common scenario may involve dis- couraging a child from exploring or playing near stairs or other falling hazards, without him directly experiencing the potential negative consequences of interacting in such an area. The trauma from experiencing...–670. [17] R. C. Browning, E. A. Baker, J. A. Herron, and R. Kram, “Effects of obesity and sex on the energetic cost and preferred speed of walking,” Journal of Applied Physiology, vol. 100, no. 2, pp. 390–398, 2006. [18] G. Cavagna, P. Franzetti, and T...

  10. Pedestrian Safety and the Built Environment

    NARCIS (Netherlands)

    Stoker, Philip; Garfinkel-Castro, Andrea; Khayesi, Meleckidzedeck; Odero, Wilson; Mwangi, M.N.; Peden, Margie; Ewing, Reid

    2015-01-01

    Urban and regional planning has a contribution to make toward improving pedestrian safety, particularly in view of the fact that about 273,000 pedestrians were killed in road traffic crashes in 2010. The road is a built environments that should enhance safety and security for pedestrians, but

  11. Food safety

    OpenAIRE

    VRABCOVÁ, Kateřina

    2012-01-01

    In the diploma thesis I was dealing with the issue of food safety in the Czech Republic and labeling of meat products. In the practical part were carried out two surveys, public opinion poll and survey of proper labeling of meat products. Opinion polls were attended by 462 consumers and analysis of proper labelling was subjected to 489 meat products in select retail chains in Prague. Survey results of labeling of meat products were not very positive, but can be expected to improve, as well as...

  12. Safety training

    CERN Document Server

    SC Unit

    2009-01-01

    Habilitation électrique A course entitled "Habilitation électrique pour personnel de laboratoire" (electrical safety qualification for laboratory personnel) will be held on 22 and 23 June. Registration by e-mail to isabelle.cusato@cern.ch. Explosion Hazards in the handling of flammable solvents and gases A course entitled "Explosion Hazards in the handling of flammable solvents and gases" given in French will be held on 18-19 June 2009. This course is obligatory for all FGSOs at CERN, and it is recommended for anyone handling flammable gas or solvents. To sign up please visit this page. For more information please contact Isabelle Cusato, tel. 73811.

  13. Preliminary study on improving safety culture in Malaysian nuclear industries

    Energy Technology Data Exchange (ETDEWEB)

    Ibrahim, Sabariah Kader [KAIST, Daejeon (Korea, Republic of); Lee, Y. E. [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2012-10-15

    This paper presents preliminary study on safety culture and its implementation in Malaysian nuclear industries by realizing the importance of safety culture; identification of important safety culture attributes; safety culture assessment and the practices to incorporate the identified safety culture attributes in organization. The first section of this paper explains the terms and definitions related to safety culture. Second, for the realization of importance of safety culture in organization, the international operational experiences emphasizing the importance of safety culture are described. Third, important safety culture attributes which are frequently cited in literature are provided. Fourth, methods to assess safety culture in operating organization are described. Finally, the practices to enhance the safety culture in an organization are discussed.

  14. Safety first

    CERN Multimedia

    2012-01-01

    Safety is a priority for CERN. That is a message I conveyed in my New Year’s address and that I reiterated at one of the first Enlarged Directorate meetings of 2012 when I outlined five key safety objectives for the year, designed and implemented according to accepted international standards.   As we move from spring to summer, it’s time to take stock of how we are doing. Objective number one for 2012, which overarches everything else, is to limit the number of incidents in the workplace. That means systematically investigating and acting on every incident that involves work stoppage, along with all the most frequent workplace accidents: falls, trips and slips. The performance indicator we set ourselves is the percentage of investigations and follow-ups completed. Year on year, these figures are rising but we can never be complacent, and must strive to reach and sustain 100% follow-up. The second objective is to improve hazard control, with a focus in 2012 on chemical ha...

  15. Construction safety

    CERN Document Server

    Li, Rita Yi Man

    2013-01-01

    A close-to-ideal blend of suburb and city, speedy construction of towers of Babylon, the sparkling proportion of glass and steel buildings’ facade at night showcase the wisdom of humans. They also witness the footsteps, sweats and tears of architects and engineers. Unfortunately, these signatures of human civilizations are swathed in towering figures of construction accidents. Fretting about these on sites, different countries adopt different measures on sites. This book firstly sketches the construction accidents on sites, followed by a review on safety measures in some of the developing countries such as Bermuda, Egypt, Kuwait and China; as well as developed countries, for example, the United States, France and Singapore. It also highlights the enormous compensation costs with the courts’ experiences in the United Kingdom and Hong Kong.

  16. Safety first

    Energy Technology Data Exchange (ETDEWEB)

    Harvie, W.

    1997-06-01

    Expansion of international business opportunities for Canadian producers and service companies brings with it a dimension almost never considered on home base - security. It was pointed out that once abroad, safety and defence of people and equipment can become significant problems in many parts of the world. The nature of the security risks involved, and how best to deal with them, were discussed. The use of consultants, mostly foreign ones to date, and the kind of assistance they can provide, everything from written reports on the local situation to counter surveillance training, and bodyguard services, have been described. Examples of recent involvements with guerilla groups demanding `revolutionary war taxes`, kidnapping executives for ransom, due diligence investigations of potential partners, and the like, have been provided to illustrate the unique character of the problem, and the constant need for being alert, educated to risks, and being prepared to react to risk situations.

  17. Global safety

    Directory of Open Access Journals (Sweden)

    Dorien J. DeTombe

    2010-08-01

    Full Text Available Global Safety is a container concept referring to various threats such as HIV/Aids, floods and terrorism; threats with different causes and different effects. These dangers threaten people, the global economy and the slity of states. Policy making for this kind of threats often lack an overview of the real causes and the interventions are based on a too shallow analysis of the problem, mono-disciplinary and focus mostly only on the effects. It would be more appropriate to develop policy related to these issues by utilizing the approaches, methods and tools that have been developed for complex societal problems. Handling these complex societal problems should be done multidisciplinary instead of mono-disciplinary. In order to give politicians the opportunity to handle complex problems multidisciplinary, multidisciplinary research institutes should be created. These multidisciplinary research institutes would provide politicians with better approaches to handle this type of problem. In these institutes the knowledge necessary for the change of these problems can be created through the use of the Compram methodology which has been developed specifically for handling complex societal problems. In a six step approach, experts, actors and policymakers discuss the content of the problem and the possible changes. The framework method uses interviewing, the Group Decision Room, simulation models and scenario's in a cooperative way. The methodology emphasizes the exchange of knowledge and understanding by communication among and between the experts, actors and politicians meanwhile keeping emotion in mind. The Compram methodology will be further explained in relation to global safety in regard to terrorism, economy, health care and agriculture.

  18. Utilization of wireless structural health monitoring as decision making tools for a condition and reliability-based assessment of railroad bridges

    Science.gov (United States)

    Flanigan, Katherine A.; Johnson, Nephi R.; Hou, Rui; Ettouney, Mohammed; Lynch, Jerome P.

    2017-04-01

    The ability to quantitatively assess the condition of railroad bridges facilitates objective evaluation of their robustness in the face of hazard events. Of particular importance is the need to assess the condition of railroad bridges in networks that are exposed to multiple hazards. Data collected from structural health monitoring (SHM) can be used to better maintain a structure by prompting preventative (rather than reactive) maintenance strategies and supplying quantitative information to aid in recovery. To that end, a wireless monitoring system is validated and installed on the Harahan Bridge which is a hundred-year-old long-span railroad truss bridge that crosses the Mississippi River near Memphis, TN. This bridge is exposed to multiple hazards including scour, vehicle/barge impact, seismic activity, and aging. The instrumented sensing system targets non-redundant structural components and areas of the truss and floor system that bridge managers are most concerned about based on previous inspections and structural analysis. This paper details the monitoring system and the analytical method for the assessment of bridge condition based on automated data-driven analyses. Two primary objectives of monitoring the system performance are discussed: 1) monitoring fatigue accumulation in critical tensile truss elements; and 2) monitoring the reliability index values associated with sub-system limit states of these members. Moreover, since the reliability index is a scalar indicator of the safety of components, quantifiable condition assessment can be used as an objective metric so that bridge owners can make informed damage mitigation strategies and optimize resource management on single bridge or network levels.

  19. Linking Safety Analysis to Safety Requirements

    DEFF Research Database (Denmark)

    Hansen, Kirsten Mark

    Software for safety critical systems must deal with the hazards identified by safety analysistechniques: Fault trees, event trees,and cause consequence diagrams can be interpreted as safety requirements and used in the design activity. We propose that the safety analysis and the system design use...... the same system model and that this model is formalized in a real-time, interval logic, based on a conventional dynamic systems model with a state over time. The three safety analysis techniques are interpreted in this model and it is shown how to derive safety requirements for components of a system....

  20. CERN's new safety policy

    CERN Multimedia

    2014-01-01

    The documents below, published on 29 September 2014 on the HSE website, together replace the document SAPOCO 42 as well as Safety Codes A1, A5, A9, A10, which are no longer in force. As from the publication date of these documents any reference made to the document SAPOCO 42 or to Safety Codes A1, A5, A9 and A10 in contractual documents or CERN rules and regulations shall be deemed to constitute a reference to the corresponding provisions of the documents listed below.   "The CERN Safety Policy" "Safety Regulation SR-SO - Responsibilities and organisational structure in matters of Safety at CERN" "General Safety Instruction GSI-SO-1 - Departmental Safety Officer (DSO)" "General Safety Instruction GSI-SO-2 - Territorial Safety Officer (TSO)" "General Safety Instruction GSI-SO-3 - Safety Linkperson (SLP)" "General Safety Instruction GSI-SO-4 - Large Experiment Group Leader In Matters of Safety (LEXGLI...

  1. Rebuilding a safety culture

    Science.gov (United States)

    Rodney, George A.

    1991-01-01

    The development of a culture of safety and NASA since the Challenger accident is reviewed. The technical elements of the strengthened NASA safety program are described, including problem reporting, risk/assessment/risk management, operational safety, and safety assurance are addressed. Future directions in the development of safety are considered.

  2. Design for safety: theoretical framework of the safety aspect of BIM system to determine the safety index

    Directory of Open Access Journals (Sweden)

    Ai Lin Evelyn Teo

    2016-12-01

    Full Text Available Despite the safety improvement drive that has been implemented in the construction industry in Singapore for many years, the industry continues to report the highest number of workplace fatalities, compared to other industries. The purpose of this paper is to discuss the theoretical framework of the safety aspect of a proposed BIM System to determine a Safety Index. An online questionnaire survey was conducted to ascertain the current workplace safety and health situation in the construction industry and explore how BIM can be used to improve safety performance in the industry. A safety hazard library was developed based on the main contributors to fatal accidents in the construction industry, determined from the formal records and existing literature, and a series of discussions with representatives from the Workplace Safety and Health Institute (WSH Institute in Singapore. The results from the survey suggested that the majority of the firms have implemented the necessary policies, programmes and procedures on Workplace Safety and Health (WSH practices. However, BIM is still not widely applied or explored beyond the mandatory requirement that building plans should be submitted to the authorities for approval in BIM format. This paper presents a discussion of the safety aspect of the Intelligent Productivity and Safety System (IPASS developed in the study. IPASS is an intelligent system incorporating the buildable design concept, theory on the detection, prevention and control of hazards, and the Construction Safety Audit Scoring System (ConSASS. The system is based on the premise that safety should be considered at the design stage, and BIM can be an effective tool to facilitate the efforts to enhance safety performance. IPASS allows users to analyse and monitor key aspects of the safety performance of the project before the project starts and as the project progresses.

  3. Autoclave nuclear criticality safety analysis

    Energy Technology Data Exchange (ETDEWEB)

    D`Aquila, D.M. [Martin Marietta Energy Systems, Inc., Piketon, OH (United States); Tayloe, R.W. Jr. [Battelle, Columbus, OH (United States)

    1991-12-31

    Steam-heated autoclaves are used in gaseous diffusion uranium enrichment plants to heat large cylinders of UF{sub 6}. Nuclear criticality safety for these autoclaves is evaluated. To enhance criticality safety, systems are incorporated into the design of autoclaves to limit the amount of water present. These safety systems also increase the likelihood that any UF{sub 6} inadvertently released from a cylinder into an autoclave is not released to the environment. Up to 140 pounds of water can be held up in large autoclaves. This mass of water is sufficient to support a nuclear criticality when optimally combined with 125 pounds of UF{sub 6} enriched to 5 percent U{sup 235}. However, water in autoclaves is widely dispersed as condensed droplets and vapor, and is extremely unlikely to form a critical configuration with released UF{sub 6}.

  4. A major safety overhaul

    CERN Multimedia

    2003-01-01

    A redefined policy, a revamped safety course, an environmental project... the TIS (Technical Inspection and Safety) Division has begun a major safety overhaul. Its new head, Wolfgang Weingarten, explains to the Bulletin why and how this is happening.

  5. Bathroom safety - adults

    Science.gov (United States)

    Older adult bathroom safety; Falls - bathroom safety ... You may need to have safety bars in your bathroom. These grab bars should be secured vertically or horizontally to the wall, not diagonally. DO NOT use ...

  6. Bromine Safety

    Energy Technology Data Exchange (ETDEWEB)

    Meyers, B

    2001-04-09

    The production and handling in 1999 of about 200 million kilograms of bromine plus substantial derivatives thereof by Great Lakes Chemical Corp. and Albemarle Corporation in their southern Arkansas refineries gave OSHA Occupational Injury/Illness Rates (OIIR) in the range of 0.74 to 1.60 reportable OIIRs per 200,000 man hours. OIIRs for similar industries and a wide selection of other U.S. industries range from 1.6 to 23.9 in the most recent OSHA report. Occupational fatalities for the two companies in 1999 were zero compared to a range in the U.S.of zero for all computer manufacturing to 0.0445 percent for all of agriculture, forestry and fishing in the most recent OSHA report. These results show that bromine and its compounds can be considered as safe chemicals as a result of the bromine safety standards and practices at the two companies. The use of hydrobromic acid as an electrical energy storage medium in reversible PEM fuel cells is discussed. A study in 1979 of 20 megawatt halogen working fluid power plants by Oronzio de Nora Group found such energy to cost 2 to 2.5 times the prevailing base rate at that time. New conditions may reduce this relative cost. The energy storage aspect allows energy delivery at maximum demand times where the energy commands premium rates. The study also found marginal cost and performance advantages for hydrobromic acid over hydrochloric acid working fluid. Separate studies in the late 70s by General Electric also showed marginal performance advantages for hydrobromic acid.

  7. Patient safety work in Sweden: quantitative and qualitative analysis of annual patient safety reports.

    Science.gov (United States)

    Ridelberg, Mikaela; Roback, Kerstin; Nilsen, Per; Carlfjord, Siw

    2016-03-21

    There is widespread recognition of the problem of unsafe care and extensive efforts have been made over the last 15 years to improve patient safety. In Sweden, a new patient safety law obliges the 21 county councils to assemble a yearly patient safety report (PSR). The aim of this study was to describe the patient safety work carried out in Sweden by analysing the PSRs with regard to the structure, process and result elements reported, and to investigate the perceived usefulness of the PSRs as a tool to achieve improved patient safety. The study was based on two sources of data: patient safety reports obtained from county councils in Sweden published in 2014 and a survey of health care practitioners with strategic positions in patient safety work, acting as key informants for their county councils. Answers to open-ended questions were analysed using conventional content analysis. A total of 14 structure elements, 31 process elements and 23 outcome elements were identified. The most frequently reported structure elements were groups devoted to working with antibiotics issues and electronic incident reporting systems. The PSRs were perceived to provide a structure for patient safety work, enhance the focus on patient safety and contribute to learning about patient safety. Patient safety work carried out in Sweden, as described in annual PSRs, features a wide range of structure, process and result elements. According to health care practitioners with strategic positions in the county councils' patient safety work, the PSRs are perceived as useful at various system levels.

  8. A culture of safety: a business strategy for medical practices.

    Science.gov (United States)

    Saxton, James W; Finkelstein, Maggie M; Marles, Adam F

    2012-01-01

    Physician practices can enhance their economics by taking patient safety to a new level within their practices. Patient safety has a lot to do with systems and processes that occur not only at the hospital but also within a physician's practice. Historically, patient safety measures have been hospital-focused and -driven, largely due to available resources; however, physician practices can impact patient safety, efficiently and effectively, with a methodical plan involving assessment, prioritization, and compliance. With the ever-increasing focus of reimbursement on quality and patient safety, physician practices that implement a true culture of safety now could see future economic benefits using this business strategy.

  9. Social Trust, Safety and the Choice of Tourist Destination

    DEFF Research Database (Denmark)

    Jensen, Susanne; Svendsen, Gert Tinggaard

    2016-01-01

    Does social trust influence safety and tourists’ destination choice? Our claim is that the roots of safety may take two forms: either formal institutions or informal institutions. Formal institutions concern how society can build up control mechanisms through the legal system, police authority...... the safety of tourists (and locals) without signalling a problem with safety. Building social trust may further enhance the feeling of safety and thereby attract even more tourists. Thus, our trust-safety theory may guide the active use of social trust by tourist officials and policy makers....

  10. Eye Protection: Safety Glasses. Safety Spotlight

    Science.gov (United States)

    Deck, Anita; Roy, Ken

    2017-01-01

    When it comes to eye safety, there are some situations in which regular safety glasses will work adequately for the needs of the STEM education classroom or laboratory. However, there are certain instances in which safety goggles must be used for safer protection. Taking the time to analyze hazards and assess the risks prior to any activity in the…

  11. Nuclear criticality safety guide

    Energy Technology Data Exchange (ETDEWEB)

    Pruvost, N.L.; Paxton, H.C. [eds.

    1996-09-01

    This technical reference document cites information related to nuclear criticality safety principles, experience, and practice. The document also provides general guidance for criticality safety personnel and regulators.

  12. Farm Health and Safety

    Science.gov (United States)

    ... jobs in the United States. Farms have many health and safety hazards, including Chemicals and pesticides Machinery, ... equipment can also reduce accidents. Occupational Safety and Health Administration

  13. New Safety rules

    CERN Multimedia

    Safety Commission

    2008-01-01

    The revision of CERN Safety rules is in progress and the following new Safety rules have been issued on 15-04-2008: Safety Procedure SP-R1 Establishing, Updating and Publishing CERN Safety rules: http://cern.ch/safety-rules/SP-R1.htm; Safety Regulation SR-S Smoking at CERN: http://cern.ch/safety-rules/SR-S.htm; Safety Regulation SR-M Mechanical Equipment: http://cern.ch/safety-rules/SR-M.htm; General Safety Instruction GSI-M1 Standard Lifting Equipment: http://cern.ch/safety-rules/GSI-M1.htm; General Safety Instruction GSI-M2 Standard Pressure Equipment: http://cern.ch/safety-rules/GSI-M2.htm; General Safety Instruction GSI-M3 Special Mechanical Equipment: http://cern.ch/safety-rules/GSI-M3.htm. These documents apply to all persons under the Director General’s authority. All Safety rules are available at the web page: http://www.cern.ch/safety-rules The Safety Commission

  14. A multicenter, randomized, controlled, single-blind comparison phase III study to determine the efficacy and safety of gadobutrol 1.0 M versus gadopentetate dimeglumine following single injection in patients referred for contrast-enhanced MRI of the body regions or extremities.

    Science.gov (United States)

    Kuwatsuru, Ryohei; Takahashi, Satoru; Umeoka, Shigeaki; Sugihara, Ryo; Zeng, Mengsu; Huan, Yi; Peng, Weijun; Ma, Lin; Guo, Liang; Teng, Gaojun; Yao, Weiwu; Tozaki, Mitsuhiro; Endo, Masahiro; Kaji, Shuichiro; Ro, Tokugen; Tae Hahn, Seong; Chul Kang, Byung; Nishimura, Hiroshi; Sugawara, Yoshifumi; Katakami, Nobuyuki; Breuer, Josy; Aitoku, Yasuko

    2015-02-01

    To demonstrate the noninferiority of gadobutrol-enhanced magnetic resonance imaging (MRI) compared with gadopentetate dimeglumine-enhanced MRI in Asian patients referred for contrast-enhanced imaging of the body or extremities. A multicenter, parallel-group comparison study of Asian adults referred for contrast-enhanced MRI were randomized (1:1) to either gadobutrol or gadopentetate dimeglumine. Lesions were assessed for three primary visualization variables: degree of contrast enhancement, border delineation, and internal morphology. Secondary efficacy variables included number of lesions detected, match of MRI diagnosis with final clinical diagnosis, and sensitivity and specificity for malignant lesion detection. Safety was monitored for 24 ± 4 hours after contrast agent administration. A total of 363 patients received either gadobutrol (n = 168) or gadopentetate dimeglumine (n = 178). Mean total scores for three primary visualization variables were 9.39 and 9.34 for gadobutrol and gadopentetate dimeglumine, respectively. The proportion of patients with matched MRI and final diagnosis and sensitivity for malignant lesion detection was greater for unenhanced versus combined images (gadobutrol: 72.2% vs. 81.7%; gadopentetate dimeglumine: 76.2% vs. 82.2%, respectively). Both contrast agents were well tolerated. Gadobutrol (0.1 mmol/kg BW) was well tolerated and effective in Asian patients referred for contrast-enhanced MRI of the body or extremities. © 2014 Wiley Periodicals, Inc.

  15. Indicators of safety culture - selection and utilization of leading safety performance indicators

    Energy Technology Data Exchange (ETDEWEB)

    Reiman, Teemu; Pietikaeinen, Elina (VTT, Technical Research Centre of Finland (Finland))

    2010-03-15

    performance indicators can help in reflecting on this model. Key questions to ask when selecting and utilizing safety performance indicators are 1) what is required from the nuclear power plant to perform safely and 2) what is required from the organization in order to be aware of its safety level and enhance its safety performance. The indicators should provide information on whether these requirements are met or not, where the organization should put more effort to meet the requirements and finally, does the organization have an accurate view on the requirements

  16. Patient safety: Safety culture and patient safety ethics

    DEFF Research Database (Denmark)

    Madsen, Marlene Dyrløv

    2006-01-01

    Patient safety - the prevention of medical error and adverse events - and the initiative of developing safety cultures to assure patients from harm have become one of the central concerns in quality improvement in healthcare both nationally andinternationally. This subject raises numerous...... the problems, and suggest possible solutions for improving patient safety through the promotion of safety culture and ethics. I seek to illuminate theissues of patient safety from several perspectives; the organizational healthcare system, in particular the healthcare workers perspectives and experiences......, and those of patients who experience the physical effect of poor patient safety. The dissertationconsists of nine papers and an appendix. Paper 1 describes the results of doctors and nurses attitudes towards reporting and the handling of adverse events. Paper 2 is a study and “review” of the international...

  17. Concept analysis of safety climate in healthcare providers.

    Science.gov (United States)

    Lin, Ying-Siou; Lin, Yen-Chun; Lou, Meei-Fang

    2017-06-01

    To report an analysis of the concept of safety climate in healthcare providers. Compliance with safe work practices is essential to patient safety and care outcomes. Analysing the concept of safety climate from the perspective of healthcare providers could improve understanding of the correlations between safety climate and healthcare provider compliance with safe work practices, thus enhancing quality of patient care. Concept analysis. The electronic databases of CINAHL, MEDLINE, PubMed and Web of Science were searched for literature published between 1995-2015. Searches used the keywords 'safety climate' or 'safety culture' with 'hospital' or 'healthcare'. The concept analysis method of Walker and Avant analysed safety climate from the perspective of healthcare providers. Three attributes defined how healthcare providers define safety climate: (1) creation of safe working environment by senior management in healthcare organisations; (2) shared perception of healthcare providers about safety of their work environment; and (3) the effective dissemination of safety information. Antecedents included the characteristics of healthcare providers and healthcare organisations as a whole, and the types of work in which they are engaged. Consequences consisted of safety performance and safety outcomes. Most studies developed and assessed the survey tools of safety climate or safety culture, with a minority consisting of interventional measures for improving safety climate. More prospective studies are needed to create interventional measures for improving safety climate of healthcare providers. This study is provided as a reference for use in developing multidimensional safety climate assessment tools and interventional measures. The values healthcare teams emphasise with regard to safety can serve to improve safety performance. Having an understanding of the concept of and interventional measures for safety climate allows healthcare providers to ensure the safety of their

  18. Leadership, safety climate, and continuous quality improvement: impact on process quality and patient safety.

    Science.gov (United States)

    McFadden, Kathleen L; Stock, Gregory N; Gowen, Charles R

    2015-01-01

    Successful amelioration of medical errors represents a significant problem in the health care industry. There is a need for greater understanding of the factors that lead to improved process quality and patient safety outcomes in hospitals. We present a research model that shows how transformational leadership, safety climate, and continuous quality improvement (CQI) initiatives are related to objective quality and patient safety outcome measures. The proposed framework is tested using structural equation modeling, based on data collected for 204 hospitals, and supplemented with objective outcome data from the Centers for Medicare and Medicaid Services. The results provide empirical evidence that a safety climate, which is connected to the chief executive officer's transformational leadership style, is related to CQI initiatives, which are linked to improved process quality. A unique finding of this study is that, although CQI initiatives are positively associated with improved process quality, they are also associated with higher hospital-acquired condition rates, a measure of patient safety. Likewise, safety climate is directly related to improved patient safety outcomes. The notion that patient safety climate and CQI initiatives are not interchangeable or universally beneficial is an important contribution to the literature. The results confirm the importance of using CQI to effectively enhance process quality in hospitals, and patient safety climate to improve patient safety outcomes. The overall pattern of findings suggests that simultaneous implementation of CQI initiatives and patient safety climate produces greater combined benefits.

  19. Nursing and patient safety in the operating room.

    Science.gov (United States)

    Alfredsdottir, Herdis; Bjornsdottir, Kristin

    2008-01-01

    This paper is a report of a study to identify what operating room nurses believe influences patient safety and how they see their role in enhancing patient safety. Research in health care shows that work experience, communication and the organization of work are key factors in patient safety. This study draws on Reason's definitions of active and latent errors to conceptualize the complex issues that affect patient safety in the operating room. The study reported here is part of an action research project at a university hospital in Iceland. Semi-structured interviews were conducted in 2004 with eight nurses, followed by two focus groups of four nurses each in 2005. Data were analysed using interpretive content analysis. Securing patient safety and preventing mistakes were described as key elements in operating room nursing by all survey participants. In the interviews, the nurses identified the existing culture of prevention and protection that characterizes operating room nursing as crucial in enhancing safety. The organization of work into specialty teams was considered essential. Increased speed of work in an environment where enhanced productivity is imperative, as well as imbalance in staffing, was identified as the main threats to safety. Operating room nurses have a common understanding of the core of their work, which is to ensure patient safety during operations. The work environment is increasingly characterized by latent error, i.e. system-based threats to patient safety that can materialize at any time. Interventions to enhance patient safety in operating room nursing are needed.

  20. Educating future leaders in patient safety

    Science.gov (United States)

    Leotsakos, Agnès; Ardolino, Antonella; Cheung, Ronny; Zheng, Hao; Barraclough, Bruce; Walton, Merrilyn

    2014-01-01

    Education of health care professionals has given little attention to patient safety, resulting in limited understanding of the nature of risk in health care and the importance of strengthening systems. The World Health Organization developed the Patient Safety Curriculum Guide: Multiprofessional Edition to accelerate the incorporation of patient safety teaching into higher educational curricula. The World Health Organization Curriculum Guide uses a health system-focused, team-dependent approach, which impacts all health care professionals and students learning in an integrated way about how to operate within a culture of safety. The guide is pertinent in the context of global educational reforms and growing recognition of the need to introduce patient safety into health care professionals’ curricula. The guide helps to advance patient safety education worldwide in five ways. First, it addresses the variety of opportunities and contexts in which health care educators teach, and provides practical recommendations to learning. Second, it recommends shared learning by students of different professions, thus enhancing student capacity to work together effectively in multidisciplinary teams. Third, it provides guidance on a range of teaching methods and pedagogical activities to ensure that students understand that patient safety is a practical science teaching them to act in evidence-based ways to reduce patient risk. Fourth, it encourages supportive teaching and learning, emphasizing the need to establishing teaching environments in which students feel comfortable to learn and practice patient safety. Finally, it helps educators incorporate patient safety topics across all areas of clinical practice. PMID:25285012

  1. Qualitative Future Safety Risk Identification an Update

    Science.gov (United States)

    Barr, Lawrence C.

    2017-01-01

    The purpose of this report is to document the results of a high-level qualitative study that was conducted to identify future aviation safety risks and to assess the potential impacts to the National Airspace System (NAS) of NASA Aviation Safety research on these risks. Multiple external sources (for example, the National Transportation Safety Board, the Flight Safety Foundation, the National Research Council, and the Joint Planning and Development Office) were used to develop a compilation of future safety issues risks, also referred to as future tall poles. The primary criterion used to identify the most critical future safety risk issues was that the issue must be cited in several of these sources as a safety area of concern. The tall poles in future safety risk, in no particular order of importance, are as follows: Runway Safety, Loss of Control In Flight, Icing Ice Detection, Loss of Separation, Near Midair Collision Human Fatigue, Increasing Complexity and Reliance on Automation, Vulnerability Discovery, Data Sharing and Dissemination, and Enhanced Survivability in the Event of an Accident.

  2. Safety at CERN

    CERN Multimedia

    2009-01-01

    Safety is an integral part of our working lives, and should be in our minds whatever job we do at CERN. Ultimately, safety is the responsibility of the Director General – your safety is my concern. That’s why I have this week appointed a new Safety Policy Committee (SAPOCO) that reflects the new Organizational structure of CERN. CERN’s Staff Rules and Regulations clearly lay out in chapter 3 the scope of safety at CERN as well as my responsibilities and yours in safety matters. At CERN, safety is considered in the broadest sense, encompassing occupational Health and Safety, environmental protection, and the safety of equipment and installations. It is my responsibility to put appropriate measures in place to ensure that these conditions are met. And it is the responsibility of us all to ensure that we are fully conversant with safety provisions applicable in our areas of work and that we comply with them. The appointment of a n...

  3. Occupational safety & health administration. Building partnerships.

    Science.gov (United States)

    Nester, R M

    1996-10-01

    1. The Office of Occupational Health Nursing, within the Occupational Safety & Health Administration (OSHA), actively advocates for workers and occupational health nurses. 2. Although an enforcement agency by law, OSHA has and is in the process of building bridges to the regulated community through its cooperative development of programs intended to enhance employer efforts for improving and maintaining employee health and workplace safety. 3. OSHA's service of consultation is geared toward the small employer seeking assistance in the recognition and correction of workplace hazards, while improving worksite health and safety programs. Voluntary Protection Programs participation, the recognition of exemplary larger employers, often leads to improvements in employee safety motivation while improving product quality, worker productivity, and corporate profits. 4. OSHA produces a wealth of publications, pamphlets, audiovisual, computer access programs and other documents designed to ease compliance while providing a foundation to the understanding of workplace health and safety.

  4. Current Activities on Nuclear Safety Culture in Korea. How to meet the challenges for Safety and Safety Culture?

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Chaewoon [International Policy Department Policy and Standard Division, Korea Institute of Nuclear Safety, 19 Gusung-Dong Yuseong-Ku, 305-338 DAEJEON (Korea, Republic of)

    2008-07-01

    information and lessons learned through symposium, meeting, and etc are also done in a harmonious way to maintain and enhance the level of safety culture in Korea. (author)

  5. TWRS safety program plan

    Energy Technology Data Exchange (ETDEWEB)

    Calderon, L.M., Westinghouse Hanford

    1996-08-01

    Management of Nuclear Safety, Industrial Safety, Industrial Hygiene, and Fire Protection programs, functions, and field support resources for Tank Waste Remediation Systems (TWRS) has, until recently, been centralized in TWRS Safety, under the Emergency, Safety, and Quality organization. Industrial hygiene technician services were also provided to support operational needs related to safety basis compliance. Due to WHC decentralization of safety and reengineering efforts in West Tank Farms, staffing and safety responsibilities have been transferred to the facilities. Under the new structure, safety personnel for TWRS are assigned directly to East Tank Farms, West Tank Farms, and a core Safety Group in TWRS Engineering. The Characterization Project Operations (CPO) safety organization will remain in tact as it currently exists. Personnel assigned to East Tank Farms, West Tank Farms, and CPO will perform facility-specific or project-specific duties and provide field implementation of programs. Those assigned to the core group will focus on activities having a TWRS-wide or programmatic focus. Hanford-wide activities will be the responsibility of the Safety Center of Expertise. In order to ensure an effective and consistent safety program for TWRS under the new organization program functions, goals, organizational structure, roles, responsibilities, and path forward must be clearly established. The purpose of the TWRS Safety Program Plan is to define the overall safety program, responsibilities, relationships, and communication linkages for safety personnel under the new structure. In addition, issues associated with reorganization transition are addressed, including training, project ownership, records management, and dissemination of equipment. For the purpose of this document ``TWRS Safety`` refers to all safety professionals and technicians (Industrial Safety, Industrial Hygiene, Fire Protection, and Nuclear Safety) within the TWRS organization, regardless of their

  6. Reliability Based Management of Marine Fouling

    DEFF Research Database (Denmark)

    Faber, Michael Havbro; Hansen, Peter Friis

    1999-01-01

    The present paper describes the results of a recent study on the application of methods from structural reliability to optimise management of marine fouling on jacket type structures.In particular the study addresses effects on the structural response by assessment and quantification of uncertain...... and more representative marine fouling profiles for design of new structures and finally an approach is outlined on how to include inspections of marine fouling into a risk based inspection philosophy.......The present paper describes the results of a recent study on the application of methods from structural reliability to optimise management of marine fouling on jacket type structures.In particular the study addresses effects on the structural response by assessment and quantification...... of uncertainties of a set of parameters. These are the seasonal variation of marine fouling parameters, the wave loading (taking into account the seasonal variation in sea-state statistics), and the effects of spatial variations and seasonal effects of marine fouling parameters. Comparison of design values...

  7. Reliability based Design of Coastal Structures

    DEFF Research Database (Denmark)

    Burcharth, H. F.

    2003-01-01

    Conventional design practice for coastal structures is deterministic in nature and is based on the concept of a design load which should not exceed the resistance (carrying capacity) of the structure. The design load is usually defined on a probabilistic basis as a characteristic value of the loa...

  8. Reliability-Based Planning of Chloride Measurements

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Engelund, S.

    1996-01-01

    In reinforced concrete structures corrosion is initiated when the chloride concentration around the reinforcement exceeds a threshold value. If corrosion starts then expensive repairs can be necessary. The estimation of the probability that corrosion has been initiated in a given structure is based...... on measurements of the chloride content obtained from the given structure. In the present paper optimal planning of measurements of the chloride content in reinforced concrete structures is considered. It is shown how optimal experimental plans can be obtained using FORM-analysis. Bayesian statistics are used...

  9. Reliability - Based Performance Assessment of Damaged Ships

    Science.gov (United States)

    2008-09-01

    amplitudes rjk. Here, the index k = 1, 2, 3, 4, 5, 6 refer to surge , sway , heave, roll, pitch and yaw modes of motion respectively. Figure 3.1-1: Co...the generalised mass; Ajk is the added mass; Bjk is the damping ; C,* is the restoring coefficients; Fj is the wave exciting force or moment. The...they’th mode of motion and Ijk is the cross-product of inertia about the origin. The added mass, damping coefficients, and wave exciting forces can be

  10. Reliability-Based Optimization of Structural Elements

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard

    In this paper structural elements from an optimization point of view are considered, i.e. only the geometry of a structural element is optimized. Reliability modelling of the structural element is discussed both from an element point of view and from a system point of view. The optimization...

  11. Medications and the Culture of Safety : Conference Title: At the Precipice of Quality Health Care: The Role of the Toxicologist in Enhancing Patient and Medication Safety Venue ACMT Pre-Meeting Symposium, 2014 North American Congress of Clinical Toxicology, New Orleans, LA.

    Science.gov (United States)

    Hemphill, Robin R

    2015-06-01

    Medication mishaps are a common cause of morbidity and mortality both within and outside of hospitals. While the use of a variety of technologies and techniques have promised to improve these statistics, instead of eliminating errors, new ones have appeared as quickly as old ones have been improved. To truly improve safety across the entire enterprise, we must ensure that we create a culture that is willing to accept that errors occur in normal course of operation to the best of people. Focus must not be on punishment and shame, but rather building a fault tolerant system that maintains safety of both staff and patients.

  12. Occupational safety motivation

    DEFF Research Database (Denmark)

    Pedersen, Louise; Kines, Pete

    2010-01-01

    Background: Motivation is one of the most important factors for safety behaviour and for implementing change in general. However, theoretical and psychometric studies of safety performance have traditionally treated safety motivation, safety compliance and safety participation unidimensionally....... At the same time many motivation questionnaire items are seldom founded on theory and/or do not account for the theories’ ontological and epistemological differences, e.g. of how knowledge, attitude and action are related. Present questionnaire items tap into occupational safety motivation in asking whether...... or not respondents ‘are’ motivated and whether they feel that safety is important or worthwhile. Another important aspect is ‘what’ motivates workers to comply to and participate in safety. The aim of this article is to introduce a new theory-based occupational safety motivation scale which is validated...

  13. Beyond safety accountability

    CERN Document Server

    Geller, E Scott

    2001-01-01

    Written in an easy-to-read conversational tone, Beyond Safety Accountability explains how to develop an organizational culture that encourages people to be accountable for their work practices and to embrace a higher sense of personal responsibility. The author begins by thoroughly explaining the difference between safety accountability and safety responsibility. He then examines the need of organizations to improve safety performance, discusses why such performance improvement can be achieved through a continuous safety process, as distinguished from a safety program, and provides the practic

  14. Safety-in-numbers

    DEFF Research Database (Denmark)

    Elvik, Rune; Bjørnskau, Torkel

    2017-01-01

    Highlights •26 studies of the safety-in-numbers effect are reviewed. •The existence of a safety-in-numbers effect is confirmed. •Results are consistent. •Causes of the safety-in-numbers effect are incompletely known.......Highlights •26 studies of the safety-in-numbers effect are reviewed. •The existence of a safety-in-numbers effect is confirmed. •Results are consistent. •Causes of the safety-in-numbers effect are incompletely known....

  15. Tutorial on nuclear thermal propulsion safety for Mars

    Energy Technology Data Exchange (ETDEWEB)

    Buden, D.

    1992-08-01

    Safety is the prime design requirement for nuclear thermal propulsion (NTP). It must be built in at the initiation of the design process. An understanding of safety concerns is fundamental to the development of nuclear rockets for manned missions to Mars and many other applications that will be enabled or greatly enhanced by the use of nuclear propulsion. To provide an understanding of the basic issues, a tutorial has been prepared. This tutorial covers a range of topics including safety requirements and approaches to meet these requirements, risk and safety analysis methodology, NERVA reliability and safety approach, and life cycle risk assessments.

  16. Tutorial on nuclear thermal propulsion safety for Mars

    Energy Technology Data Exchange (ETDEWEB)

    Buden, D.

    1992-01-01

    Safety is the prime design requirement for nuclear thermal propulsion (NTP). It must be built in at the initiation of the design process. An understanding of safety concerns is fundamental to the development of nuclear rockets for manned missions to Mars and many other applications that will be enabled or greatly enhanced by the use of nuclear propulsion. To provide an understanding of the basic issues, a tutorial has been prepared. This tutorial covers a range of topics including safety requirements and approaches to meet these requirements, risk and safety analysis methodology, NERVA reliability and safety approach, and life cycle risk assessments.

  17. Road safety rhetoric versus road safety politics.

    Science.gov (United States)

    Køltzow, K

    1993-12-01

    In-depth interviews with top level decision makers in the road sector in Norway were conducted over a four-year period: Three principal impediments to safety interventions were identified: (i) Mobility is considered of primary importance; the "freedom of the car" is difficult to restrict, (ii) as a consequence there is much more lobbying for mobility than for safety, and (iii) road safety commitment and policies are weak, even among some of those responsible. For these reasons, efficient road safety work is often side-tracked at the top level, and substituted by nonbinding demands for road users' "change of attitude". In addition, road safety is often used as a proxy argument for measures that mainly promote mobility.

  18. Safety KPIs - Monitoring of safety performance

    Directory of Open Access Journals (Sweden)

    Andrej Lališ

    2014-09-01

    Full Text Available This paper aims to provide brief overview of aviation safety development focusing on modern trends represented by implementation of Safety Key Performance Indicators. Even though aviation is perceived as safe means of transport, it is still struggling with its complexity given by long-term growth and robustness which it has reached today. Thus nowadays safety issues are much more complex and harder to handle than ever before. We are more and more concerned about organizational factors and control mechanisms which have potential to further increase level of aviation safety. Within this paper we will not only introduce the concept of Key Performance Indicators in area of aviation safety as an efficient control mechanism, but also analyse available legislation and documentation. Finally we will propose complex set of indicators which could be applied to Czech Air Navigation Service Provider.

  19. Patient safety: Safety culture and patient safety ethics

    OpenAIRE

    Madsen, Marlene Dyrløv

    2006-01-01

    Patient safety - the prevention of medical error and adverse events - and the initiative of developing safety cultures to assure patients from harm have become one of the central concerns in quality improvement in healthcare both nationally andinternationally. This subject raises numerous challenging issues of systemic, organisational, cultural and ethical relevance, which this dissertation seeks to address through the application of different disciplinary approaches. The main focus of resear...

  20. National Safety Council

    Science.gov (United States)

    ... Practical Solutions & Training Tools Online Learning Safety Awards & Recognition Publications, Library & Research Get Support for Safety Membership Logos Networking & Additional Resources Member Appreciation Month NSC Division Networks Alcohol & Drug Impairment Business & ...

  1. Car Seat Safety

    Science.gov (United States)

    ... to Talk to Your Child About the News Gun Safety Too Late for the Flu Vaccine? Eating ... many local health departments, public safety groups, hospitals, law enforcement agencies, and fire departments have technicians or ...

  2. Flu Vaccine Safety Information

    Science.gov (United States)

    ... Types Seasonal Avian Swine/Variant Pandemic Other Flu Vaccine Safety Information Questions & Answers Language: English (US) Español ... of flu vaccines monitored? Egg Allergy Are flu vaccines safe? Flu vaccines have good safety record. Hundreds ...

  3. Fires and Food Safety

    Science.gov (United States)

    ... Standard Forms FSIS United States Department of Agriculture Food Safety and Inspection Service About FSIS District Offices Careers ... Viewer (JSR 286) Actions ${title} Loading... Fires and Food Safety Fire! Few words can strike such terror. Residential ...

  4. Freezing and Food Safety

    Science.gov (United States)

    ... Standard Forms FSIS United States Department of Agriculture Food Safety and Inspection Service About FSIS District Offices Careers ... Viewer (JSR 286) Actions ${title} Loading... Freezing and Food Safety What Can You Freeze? Is Frozen Food Safe? ...

  5. Fire Safety (For Parents)

    Science.gov (United States)

    ... of Braces Eating Disorders Mitral Valve Prolapse Arrhythmias Fire Safety KidsHealth > For Parents > Fire Safety Print A ... event of a fire emergency in your home. Fire Prevention Of course, the best way to practice ...

  6. Refrigeration and Food Safety

    Science.gov (United States)

    ... Forms Standard Forms FSIS United States Department of Agriculture Food Safety and Inspection Service About FSIS District ... 286) Actions ${title} Loading... Refrigeration and Food Safety History of Refrigeration Importance of Refrigeration Types of Bacteria ...

  7. National Patient Safety Foundation

    Science.gov (United States)

    ... News Member Testimonials Lifetime Members Stand Up for Patient Safety Welcome Stand Up Members Stand Up e-News ... PLS Webcast Archives Stand Up Templates and Logos Patient Safety Coalition Coalition Overview Coalition Member Roster Members-Only ...

  8. Water safety and drowning

    Science.gov (United States)

    ... among people of all ages. Learning and practicing water safety is important to prevent drowning accidents. ... Water safety tips for all ages include: Learn CPR . Never swim alone. Never dive into water unless ...

  9. Animal Product Safety Information

    Science.gov (United States)

    ... Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Animal & Veterinary Home Animal & Veterinary Safety & Health Product Safety ... for more information. How to report when your animal has a bad reaction to a drug the ...

  10. General safety considerations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-09-01

    This document presents the full filling of the Brazilian obligations under the Convention on Nuclear Safety. The Chapter 4 of the document contains some details about the priority to safety, financial and human resources, human factors, quality assurance, safety assessment and verification, radiation protection and emergency preparedness.

  11. Improving patient safety culture

    NARCIS (Netherlands)

    Hellings, Johan; Schrooten, Ward; Klazinga, Niek S.; Vleugels, Arthur

    2010-01-01

    PURPOSE: Improving hospital patient safety means an open and stimulating culture is needed. This article aims to describe a patient safety culture improvement approach in five Belgian hospitals. DESIGN/METHODOLOGY/APPROACH: Patient safety culture was measured using a validated Belgian adaptation of

  12. Leadership and safety culture. Leadership for safety

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Erwin; Nithack, Eckhard [PreussenElektra GmbH, Hannover (Germany)

    2016-08-15

    The meaning of leadership for safety in the nuclear industry is pointed out. This topic has became an increasing rank since the German ''Energiewende''. Despite the phase-out of the German NPP's nuclear safety and the belonging safety culture needs to be well maintained. A challenge for the whole organisation. Following the challenge to operate nuclear power plants towards Operational Excellence a highly skilled and motivated organisation is needed. Therefore Leadership is a valuable success factor.

  13. Safety culture : a significant influence on safety in transportation

    Science.gov (United States)

    2017-08-01

    An organizations safety culture can influence safety outcomes. Research and experience show that when safety culture is strong, accidents are less frequent and less severe. As a result, building and maintaining strong safety cultures should be a t...

  14. Patient Education May Improve Perioperative Safety.

    NARCIS (Netherlands)

    de Haan, L.S.; Calsbeek, H; Wolff, André

    2016-01-01

    Importance: There is a growing interest in enabling ways for patients to participate in their own care to improve perioperative safety, but little is known about the effectiveness of interventions enhancing an active patient role. Objective: To evaluate the effect of patient participation on

  15. Integral urban project and safety. Building barriers or bridges?

    CSIR Research Space (South Africa)

    Landman, K

    2006-03-01

    Full Text Available Planning and design measures can be utilised successfully to enhance feelings of safety in areas where people feel vulnerable. The study of the relationship between crime and the physical environment has resulted in various theoretical approaches...

  16. Uncertain safety: allocating responsibilities for safety

    National Research Council Canada - National Science Library

    2009-01-01

    Flood prevention, food safety, the transport of hazardous substances, infectious diseases, the risk of new Technologies and many other threats to public health and the environment call for ongoing public alertness...

  17. Workplace Safety and Health Topics: Safety & Prevention

    Science.gov (United States)

    ... Childhood Agricultural Injury Prevention Control Banding Controls for Noise Exposure Cost-effective Rollover Protective Structures (CROPS) Direct Reading and Sensor Technologies Distracted Driving at Work Electrical Safety Electronic Health Records (EHRs) and Patient ...

  18. Safety in Cryogenics – Safety device sizing

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    The calculation is separated in three operations: o The estimation of the loads arriving on the component to protect, o The calculation of the mass flow to evacuate, o And the sizing of the safety device.

  19. Research status of warship fire safety engineering

    Directory of Open Access Journals (Sweden)

    LU Shouxiang

    2017-10-01

    Full Text Available The theory of warship fire safety engineering is the basis of damage control engineering. According to the public safety triangle and the characteristics of ship damage protection engineering, this paper proposes a theoretical framework system for ship fire safety engineering, including ship fire development, ship fire damage and ship fire protection. The progress of these three parts are summarized in such aspects as enclosed fire dynamics, open space fire dynamics, fire damage mechanisms for personnel, equipment and structures, fire smoke control, fire elimination technology and new fire extinguishing technology. By optimizing the theoretical system of warship fire safety engineering and improving fire prevention and control technology, the survivability of warships will be enhanced.

  20. Impact of Construction Health & Safety Regulations on Project ...

    African Journals Online (AJOL)

    The effectiveness of the construction industry can only be enhanced by repositioning the construction health and safety regulations to safeguard the health of the workers and the entire community. This paper seeks to assess the views of consultants and contractors about the impact of construction health and safety ...

  1. Designing continuous safety improvement within chemical industrial areas

    NARCIS (Netherlands)

    Reniers, G.L.L.; Ale, B. J.M.; Dullaert, W.; Soudan, K.

    This article provides support in organizing and implementing novel concepts for enhancing safety on a cluster level of chemical plants. The paper elaborates the requirements for integrating Safety Management Systems of chemical plants situated within a so-called chemical cluster. Recommendations of

  2. 50 CFR 401.17 - Safety and accident prevention.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Safety and accident prevention. 401.17 Section 401.17 Wildlife and Fisheries JOINT REGULATIONS (UNITED STATES FISH AND WILDLIFE SERVICE... FISHERIES CONSERVATION, DEVELOPMENT AND ENHANCEMENT § 401.17 Safety and accident prevention. In the...

  3. Patient Safety Culture

    DEFF Research Database (Denmark)

    Kristensen, Solvejg

    Patient safety is highly prioritised in the Danish health care system, never the less, patients are still exposed to risk and harmed every day. Implementation of a patient safety culture has been suggested an effective mean to protect patients against adverse events. Working strategically...... with assessment and development of the patient safety culture is in early days in Denmark. It depends upon valid, reliable and effective methods. The patient safety culture represents a wide range of social phenomena permeating the way of life in a health care. In essence, the safety culture is an aggregation...... of health care professional’s behaviour, habits, norms, values, and basic assumptions related to patient care; it is the way things are done. The patient safety culture guides the motivation, commitment to and know-how of the safety management, and how all members of a work place interact. This thesis...

  4. System Safety in an IT Service Organization

    Science.gov (United States)

    Parsons, Mike; Scutt, Simon

    Within Logica UK, over 30 IT service projects are considered safetyrelated. These include operational IT services for airports, railway infrastructure asset management, nationwide radiation monitoring and hospital medical records services. A recent internal audit examined the processes and documents used to manage system safety on these services and made a series of recommendations for improvement. This paper looks at the changes and the challenges to introducing them, especially where the service is provided by multiple units supporting both safety and non-safety related services from multiple locations around the world. The recommendations include improvements to service agreements, improved process definitions, routine safety assessment of changes, enhanced call logging, improved staff competency and training, and increased safety awareness. Progress is reported as of today, together with a road map for implementation of the improvements to the service safety management system. A proposal for service assurance levels (SALs) is discussed as a way forward to cover the wide variety of services and associated safety risks.

  5. Formal Safety versus Real Safety: Quantitative and Qualitative Approaches to Safety Culture – Evidence from Estonia

    Directory of Open Access Journals (Sweden)

    Järvis Marina

    2016-10-01

    Full Text Available This paper examines differences between formal safety and real safety in Estonian small and medium-sized enterprises. The results reveal key issues in safety culture assessment. Statistical analysis of safety culture questionnaires showed many organisations with an outstanding safety culture and positive safety attitudes. However, qualitative data indicated some important safety weaknesses and aspects that should be included in the process of evaluation of safety culture in organisations.

  6. Reliability and safety engineering

    CERN Document Server

    Verma, Ajit Kumar; Karanki, Durga Rao

    2016-01-01

    Reliability and safety are core issues that must be addressed throughout the life cycle of engineering systems. Reliability and Safety Engineering presents an overview of the basic concepts, together with simple and practical illustrations. The authors present reliability terminology in various engineering fields, viz.,electronics engineering, software engineering, mechanical engineering, structural engineering and power systems engineering. The book describes the latest applications in the area of probabilistic safety assessment, such as technical specification optimization, risk monitoring and risk informed in-service inspection. Reliability and safety studies must, inevitably, deal with uncertainty, so the book includes uncertainty propagation methods: Monte Carlo simulation, fuzzy arithmetic, Dempster-Shafer theory and probability bounds. Reliability and Safety Engineering also highlights advances in system reliability and safety assessment including dynamic system modeling and uncertainty management. Cas...

  7. Safety objectives for 2014

    CERN Multimedia

    HSE Unit

    2014-01-01

    This is the third year in which the CERN Management has presented annual safety objectives for the Organization, the “HSE Objectives”.   The HSE objectives for 2014, which were announced by the Director-General at his traditional New Year’s address to the staff and were presented at the first Enlarged Directorate meeting of the year, have been drawn up and agreed in close collaboration between the DSOs, the HSE Unit and the DG himself. From safety in the workplace to radiation and environmental protection, the document emphasises that “Safety is a priority for CERN” and that safety policy is a key element in how the Organization is run. And, like all policies, it generates objectives that “serve as a general framework for action”. The HSE objectives are broken down into the following fields: occupational health and safety on sites and in the workplace, radiation protection, radiation safety, environmental protection, emerge...

  8. Safety advice sheets

    CERN Multimedia

    HSE Unit

    2013-01-01

    You never know when you might be faced with questions such as: when/how should I dispose of a gas canister? Where can I find an inspection report? How should I handle/store/dispose of a chemical substance…?   The SI section of the DGS/SEE Group is primarily responsible for safety inspections, evaluating the safety conditions of equipment items, premises and facilities. On top of this core task, it also regularly issues “Safety Advice Sheets” on various topics, designed to be of assistance to users but also to recall and reinforce safety rules and procedures. These clear and concise sheets, complete with illustrations, are easy to display in the appropriate areas. The following safety advice sheets have been issued so far: Other sheets will be published shortly. Suggestions are welcome and should be sent to the SI section of the DGS/SEE Group. Please send enquiries to general-safety-visits.service@cern.ch.

  9. Thermal reactor safety

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    Information is presented concerning new trends in licensing; seismic considerations and system structural behavior; TMI-2 risk assessment and thermal hydraulics; statistical assessment of potential accidents and verification of computational methods; issues with respect to improved safety; human factors in nuclear power plant operation; diagnostics and activities in support of recovery; LOCA transient analysis; unresolved safety issues and other safety considerations; and fission product transport.

  10. Hydrogen Technologies Safety Guide

    Energy Technology Data Exchange (ETDEWEB)

    Rivkin, C. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Burgess, R. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Buttner, W. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-01-01

    The purpose of this guide is to provide basic background information on hydrogen technologies. It is intended to provide project developers, code officials, and other interested parties the background information to be able to put hydrogen safety in context. For example, code officials reviewing permit applications for hydrogen projects will get an understanding of the industrial history of hydrogen, basic safety concerns, and safety requirements.

  11. Principles of electrical safety

    CERN Document Server

    Sutherland, Peter E

    2015-01-01

    Principles of Electrical Safety discusses current issues in electrical safety, which are accompanied by series' of practical applications that can be used by practicing professionals, graduate students, and researchers. .  Provides extensive introductions to important topics in electrical safety Comprehensive overview of inductance, resistance, and capacitance as applied to the human body Serves as a preparatory guide for today's practicing engineers

  12. Factors influencing patient safety in Sweden: perceptions of patient safety officers in the county councils

    Directory of Open Access Journals (Sweden)

    Nygren Mikaela

    2013-02-01

    constrained. They attribute the current levels of patient safety to a broad range of factors and believe that many different solutions can contribute to enhanced patient safety in the future, suggesting that this work must be multifactorial.

  13. Lift truck safety review

    Energy Technology Data Exchange (ETDEWEB)

    Cadwallader, L.C.

    1997-03-01

    This report presents safety information about powered industrial trucks. The basic lift truck, the counterbalanced sit down rider truck, is the primary focus of the report. Lift truck engineering is briefly described, then a hazard analysis is performed on the lift truck. Case histories and accident statistics are also given. Rules and regulations about lift trucks, such as the US Occupational Safety an Health Administration laws and the Underwriter`s Laboratories standards, are discussed. Safety issues with lift trucks are reviewed, and lift truck safety and reliability are discussed. Some quantitative reliability values are given.

  14. FOOD SAFETY TESTING LABORATORY

    Data.gov (United States)

    Federal Laboratory Consortium — This laboratory develops screening assays, tests and modifies biosensor equipment, and optimizes food safety testing protocols for the military and civilian sector...

  15. Training safely, Training safety

    Directory of Open Access Journals (Sweden)

    Jianjun Wu

    2014-09-01

    Full Text Available It is the basic requirement of maritime safety education to guarantee the safety of teaching operation while training the crew's occupation safety capability. Marine Training Center of Shanghai Maritime University has undertaken the practical teaching of "marine survival" for many years and come up with the whole safety procedures of training. Based on the requirements of SOLAS convention and regulations of STCW over crew training, this paper introduces the safety allocation, utilization and maintenance of teaching equipments. Through the investigation of the safety situation of students' practical operation, the safety teaching method named "four in one" has been put forward, which includes the pre-teaching safety precaution, the whole monitor during the teaching process, the post-teaching summary evaluation, and the reset and standby of teaching facilities. Finally, during the learning and training of "marine survival", crews and students are called on to place priority on personal safety rather than acquisition of knowledge and skills. Only in this way can they be capable of self-protection and protection of others in the career of seafaring.

  16. Improved safety at CERN

    CERN Multimedia

    2006-01-01

    As announced in Weekly Bulletin No. 43/2006, a new approach to the implementation of Safety at CERN has been decided, which required taking some managerial decisions. The guidelines of the new approach are described in the document 'New approach to Safety implementation at CERN', which also summarizes the main managerial decisions I have taken to strengthen compliance with the CERN Safety policy and Rules. To this end I have also reviewed the mandates of the Safety Commission and the Safety Policy Committee (SAPOCO). Some details of the document 'Safety Policy at CERN' (also known as SAPOCO42) have been modified accordingly; its essential principles, unchanged, remain the basis for the safety policy of the Organisation. I would also like to inform you that I have appointed Dr M. Bona as the new Head of the Safety Commission until 31.12.2008, and that I will proceed soon to the appointment of the members of the new Safety Policy Committee. All members of the personnel are deemed to have taken note of the d...

  17. Light water reactor safety

    CERN Document Server

    Pershagen, B

    2013-01-01

    This book describes the principles and practices of reactor safety as applied to the design, regulation and operation of light water reactors, combining a historical approach with an up-to-date account of the safety, technology and operating experience of both pressurized water reactors and boiling water reactors. The introductory chapters set out the basic facts upon which the safety of light water reactors depend. The central section is devoted to the methods and results of safety analysis. The accidents at Three Mile Island and Chernobyl are reviewed and their implications for light wate

  18. Safety and radiation-enhancing effect of sodium glycididazole in loco regionally advanced laryngeal cancers previously treated with platinum-containing chemotherapy regimens: a preliminary report; Tolerance et effet radiosensibilisateur du sodium glycididazole chez des patients atteints de cancer du larynx localement evolue ayant prealablement recu une chimiotherapie a base de cisplatine: rapport preliminaire

    Energy Technology Data Exchange (ETDEWEB)

    Zeng, Y.C.; Wu, R.; Xu, Z.G.; Zhang, X.Y.; Wu, L.N.; Wang, Y.M.; Zheng, W.; Chen, X.D.; Chi, F.; Zhang, Z.Y.; Li, X.; Jin, X.Y.; Chen, W.; Wang, S.L.; Xiao, F.D.; Wang, E.Y.; Dong, X.Q.; Jia, M.X.; Li, Y. [China Medical Univ., Dept. of Medical Oncology, Shengjing Hospital, Shenyang, PR (China); Fan, G.L. [Harbin First Hospital, Dept. of Otorhinolaryngology, PR (China); Hao, S.H.; Zhang, L.B.; Zhang, H.B. [General Hospital of Shenyang Military Region, Dept. of Nuclear Medicine and Radiology, Shenyang, PR (China); Xia, H.H.X. [Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (United States)

    2010-01-15

    Purpose: To determine the safety and radiation-enhancing effect of sodium glycididazole in laryngeal squamous cell carcinoma (stage T3-4,N0-3,M0) with conventional radiotherapy. Patients and methods: Patients with locoregional advanced laryngeal cancer (stage T3-4,N0-3,M0) were included: group 1(control, n = 30)were not administered of sodium glycididazole; group 2 (test, n = 30) received sodium glycididazole at a dose of 700 mg/m2 intravenous infusion 30 minutes before radiotherapy three times a week. Surrogate end-points of efficacy were tumor and nodal size. Safety parameters were vomiting, nausea, mucositis, laryngeal edema, esophagus and skin reaction, dysphagia, dyspnea, neurological deficit. Patients were evaluated weekly during treatment for 7 weeks and thereafter monthly for 3 months. Results: In the test, the overall response rate was 88.89% (95% CI, 71.00-97.00%) at 7 weeks and 92.59% (95% CI, 76.00 to 99.00%) at 1 month of follow-up. In the control, the overall response rate was 62.5% (95% CI, 41.00 to 81.00%) at 7 weeks and 58.33% (95% CI, 37.00 to 78.00%) at 1 month of follow-up. The short-term locoregional response rate was better in the test group at 7 weeks (p = 0.027) and at 1 month (p = 0.005) of follow-up. The test group had significantly more nausea and vomiting in weeks 1 (p = 0.047), 2 (p = 0.007), and 3 (p = 0.01) of treatment. Conclusions: The study indicates sodium glycididazole is an effective radiation-enhancing agent that improves short-term locoregional control and is well tolerated in patients with loco regionally advanced laryngeal cancer. (authors)

  19. Reactor Safety Research: Semiannual report, July-December 1986

    Energy Technology Data Exchange (ETDEWEB)

    1987-11-01

    Sandia National Laboratories is conducting, under USNRC sponsorship, phenomenological research related to the safety of commercial nuclear power reactors. The research includes experiments to simulate the phenomenology of the accident conditions and the development of analytical models, verified by experiment, which can be used to predict reactor and safety systems performance and behavior under abnormal conditions. The objective of this work is to provide NRC requisite data bases and analytical methods to (1) identify and define safety issues, (2) understand the progression of risk-significant accident sequences, and (3) conduct safety assessments. The collective NRC-sponsored effort at Sandia National Laboratories is directed at enhancing the tehcnology base supporting licensing decisions.

  20. A Silent Safety Program

    Science.gov (United States)

    Goodin, James Ronald

    2006-01-01

    NASA's Columbia Accident Investigation Board (CAIB) referred 8 times to the NASA "Silent Safety Program." This term, "Silent Safety Program" was not an original observation but first appeared in the Rogers Commission's Investigation of the Challenger Mishap. The CAIB on page 183 of its report in the paragraph titled 'Encouraging Minority Opinion,' stated "The Naval Reactor Program encourages minority opinions and "bad news." Leaders continually emphasize that when no minority opinions are present, the responsibility for a thorough and critical examination falls to management. . . Board interviews revealed that it is difficult for minority and dissenting opinions to percolate up through the agency's hierarchy. . ." The first question and perhaps the only question is - what is a silent safety program? Well, a silent safety program may be the same as the dog that didn't bark in Sherlock Holmes' "Adventure of the Silver Blaze" because system safety should behave as a devil's advocate for the program barking on every occasion to insure a critical review inclusion. This paper evaluates the NASA safety program and provides suggestions to prevent the recurrence of the silent safety program alluded to in the Challenger Mishap Investigation. Specifically targeted in the CAM report, "The checks and balances the safety system was meant to provide were not working." A silent system safety program is not unique to NASA but could emerge in any and every organization. Principles developed by Irving Janis in his book, Groupthink, listed criteria used to evaluate an organization's cultural attributes that allows a silent safety program to evolve. If evidence validates Jams's criteria, then Jams's recommendations for preventing groupthink can also be used to improve a critical evaluation and thus prevent the development of a silent safety program.

  1. The influence of authentic leadership on safety climate in nursing.

    Science.gov (United States)

    Dirik, Hasan Fehmi; Seren Intepeler, Seyda

    2017-07-01

    This study analysed nurses' perceptions of authentic leadership and safety climate and examined the contribution of authentic leadership to the safety climate. It has been suggested and emphasised that authentic leadership should be used as a guidance to ensure quality care and the safety of patients and health-care personnel. This predictive study was conducted with 350 nurses in three Turkish hospitals. The data were collected using the Authentic Leadership Questionnaire and the Safety Climate Survey and analysed using hierarchical regression analysis. The mean authentic leadership perception and the safety climate scores of the nurses were 2.92 and 3.50, respectively. The percentage of problematic responses was found to be less than 10% for only four safety climate items. Hierarchical regression analysis revealed that authentic leadership significantly predicted the safety climate. Procedural and political improvements are required in terms of the safety climate in institutions, where the study was conducted, and authentic leadership increases positive perceptions of safety climate. Exhibiting the characteristics of authentic leadership, or improving them and reflecting them on to personnel can enhance the safety climate. Planning information sharing meetings to raise the personnel's awareness of safety climate and systemic improvements can contribute to creating safe care climates. © 2017 John Wiley & Sons Ltd.

  2. A word from the DG: Improved safety at CERN

    CERN Document Server

    2006-01-01

    One of the important objectives of my term of office is improving safety at CERN. My consideration of safety issues over the last few months, in conjunction with the Safety Commission and the Heads of Department, has led me to define a new approach for the implementation of safety policy at CERN. It is not a question of changing the safety policy and the basic safety rules laid down in document 'Safety Policy at CERN' (SAPOCO 42) but, rather, of improving the way they are applied by clarifying the roles of everyone concerned. The existing safety policy and rules have yet to be fully implemented. Some people continue to think, for example, that safety implementation only concerns the Safety Commission (SC). In reality, as SAPOCO 42 clearly specifies, safety is the responsibility of each and every individual. This means that each person in charge of a task is also responsible for guaranteeing its safe completion by implementing all the necessary measures. To enhance the awareness of this responsibility and t...

  3. Leader communication approaches and patient safety: An integrated model.

    Science.gov (United States)

    Mattson, Malin; Hellgren, Johnny; Göransson, Sara

    2015-06-01

    Leader communication is known to influence a number of employee behaviors. When it comes to the relationship between leader communication and safety, the evidence is more scarce and ambiguous. The aim of the present study is to investigate whether and in what way leader communication relates to safety outcomes. The study examines two leader communication approaches: leader safety priority communication and feedback to subordinates. These approaches were assumed to affect safety outcomes via different employee behaviors. Questionnaire data, collected from 221 employees at two hospital wards, were analyzed using structural equation modeling. The two examined communication approaches were both positively related to safety outcomes, although leader safety priority communication was mediated by employee compliance and feedback communication by organizational citizenship behaviors. The findings suggest that leader communication plays a vital role in improving organizational and patient safety and that different communication approaches seem to positively affect different but equally essential employee safety behaviors. The results highlights the necessity for leaders to engage in one-way communication of safety values as well as in more relational feedback communication with their subordinates in order to enhance patient safety. Copyright © 2015 Elsevier Ltd. and National Safety Council. Published by Elsevier Ltd. All rights reserved.

  4. Highway Safety Program Manual: Volume 3: Motorcycle Safety.

    Science.gov (United States)

    National Highway Traffic Safety Administration (DOT), Washington, DC.

    Volume 3 of the 19-volume Highway Safety Program Manual (which provides guidance to State and local governments on preferred highway safety practices) concentrates on aspects of motorcycle safety. The purpose and specific objectives of a State motorcycle safety program are outlined. Federal authority in the highway safety area and general policies…

  5. 75 FR 32877 - Financial Assistance: Wildlife Restoration, Sport Fish Restoration, Hunter Education and Safety

    Science.gov (United States)

    2010-06-10

    ..., Sport Fish Restoration, and Hunter Education and Safety (Enhanced Hunter Education and Safety) financial... Hunter Education and Safety program; and (d) receive financial assistance from the Sport Fish Restoration... wildlife agencies to: (a) Restore or manage wildlife and sport fish; (b) provide hunter- education, hunter...

  6. 77 FR 72998 - Policy Statement on Occupational Safety and Health Standards for Aircraft Cabin Crewmembers

    Science.gov (United States)

    2012-12-07

    ... a proposed policy statement regarding the regulation of some occupational safety and health...). This policy statement will enhance occupational safety and health in the aircraft cabin by establishing... Federal Aviation Administration 14 CFR Parts 91, 121, 125 and 135 Policy Statement on Occupational Safety...

  7. 75 FR 65359 - Common Formats for Patient Safety Data Collection and Event Reporting

    Science.gov (United States)

    2010-10-22

    ... HUMAN SERVICES Agency for Healthcare Research and Quality Common Formats for Patient Safety Data... of availability--revised and enhanced event-specific common format. SUMMARY: The Patient Safety and Quality Improvement Act of 2005, 42 U.S.C. 299b-21 to b-26, (Patient Safety Act) provides for the...

  8. 75 FR 20009 - Development of NRC's Safety Culture Policy Statement: Cancellation of Public Workshops Scheduled...

    Science.gov (United States)

    2010-04-16

    ... COMMISSION Development of NRC's Safety Culture Policy Statement: Cancellation of Public Workshops Scheduled... forging a consensus around the objectives, strategies, activities and measures that enhance safety culture... culture common terminology effort comprised of: (1) Development of a common safety culture definition; and...

  9. Safety Training: basic safety and access courses

    CERN Multimedia

    2005-01-01

    Objective The purpose of the basic safety courses is to increase awareness for everyone working on the CERN site (CERN staff, associates, outside companies, students and apprentices) of the various hazards existing on site, and how to recognise and avoid them. Safety course changes The current organisation of basic safety courses is changing. There will be two main modifications: the organisation of the courses and the implementation of a specific new training course for the LHC machine during the LHC tests and hardware commissioning phase. Organisational changes This concerns the existing basic safety training, currently called level 1, level 2 and level 3. Under the new procedure, a video will be projected in registration building 55 and will run every day at 14.00 and 15.00 in English. The duration of the video will be 50 minutes. The course contents will be the same as the slides currently used, plus a video showing real situations. With this new organization, participants will systematically follow...

  10. Safety Training: Basic Safety and Access Courses

    CERN Multimedia

    Antonella Vignes

    2005-01-01

    Objective The purpose of the basic safety courses is to increase awareness for everyone working on the CERN site (CERN staff, associates, outside companies, students and apprentices) of the various existing on-site hazards, and how to recognize and avoid them. Safety course changes The current organization for basic safety courses is changing. There will be two main modifications: the organization of the courses and the implementation of a specific new training course for the LHC machine during the LHC tests and hardware commissioning phase. Organizational changes This concerns the existing basic safety training, currently called level1, level2 and level3. Under the new procedure, a video will be projected in registration building 55 and will run every day at 14.00 and 15.00 in English. The duration of the video will be 50 minutes. The course contents will be the same as the slides currently used, plus a video showing real situations. With this new organization, attendees will systematically follow the...

  11. Subjective safety in traffic.

    NARCIS (Netherlands)

    2012-01-01

    The term ‘subjective safety in traffic’ refers to people feeling unsafe in traffic or, more generally, to anxiety regarding being unsafe in traffic for oneself and/or others. Subjective safety in traffic can lead to road users limiting their mobility and social activities, which is one of the

  12. Aviation safety and ICAO

    NARCIS (Netherlands)

    Huang, Jiefang

    2009-01-01

    The thesis addresses the issue of aviation safety under the rule of law. Aviation safety is a global concern. While air transport is considered a safe mode of travel, it is susceptible to inherent risks of flight, the use of force, and terrorist acts. Consequently, within the framework of the

  13. Safety in Aquaculture

    Science.gov (United States)

    Durborow, Robert M.; Myers, Melvin L.

    2016-01-01

    In this article, occupational safety interventions for agriculture-related jobs, specifically in aquaculture, are reviewed. Maintaining quality of life and avoiding economic loss are two areas in which aquaculturists can benefit by incorporating safety protocols and interventions on their farms. The information in this article is based on farm…

  14. Elements of nuclear safety

    CERN Document Server

    Libmann, Jacques

    1996-01-01

    This basically educational book is intended for all involved in nuclear facility safety. It dissects the principles and experiences conducive to the adoption of attitudes compliant with what is now known as "safety culture". This book is accessible to a wide range of readers.

  15. Safety analysis for `Fugen`

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    The improvement of safety in nuclear power stations is an important proposition. Therefore also as to the safety evaluation, it is important to comprehensively and systematically execute it by referring to the operational experience and the new knowledge which is important for the safety throughout the period of use as well as before the construction and the start of operation of nuclear power stations. In this report, the results when the safety analysis for ``Fugen`` was carried out by referring to the newest technical knowledge are described. As the result, it was able to be confirmed that the safety of ``Fugen`` has been secured by the inherent safety and the facilities which were designed for securing the safety. The basic way of thinking on the safety analysis including the guidelines to be conformed to is mentioned. As to the abnormal transient change in operation and accidents, their definition, the events to be evaluated and the standards for judgement are reported. The matters which were taken in consideration at the time of the analysis are shown. The computation programs used for the analysis were REACT, HEATUP, LAYMON, FATRAC, SENHOR, LOTRAC, FLOOD and CONPOL. The analyses of the abnormal transient change in operation and accidents are reported on the causes, countermeasures, protective functions and results. (K.I.)

  16. Safety in cardiac surgery

    NARCIS (Netherlands)

    Siregar, S.

    2013-01-01

    The monitoring of safety in cardiac surgery is a complex process, which involves many clinical, practical, methodological and statistical issues. The objective of this thesis was to measure and to compare safety in cardiac surgery in The Netherlands using the Netherlands Association for

  17. Safety Behaviors and Stuttering

    Science.gov (United States)

    Lowe, Robyn; Helgadottir, Fjola; Menzies, Ross; Heard, Rob; O'Brian, Sue; Packman, Ann; Onslow, Mark

    2017-01-01

    Purpose: Those who are socially anxious may use safety behaviors during feared social interactions to prevent negative outcomes. Safety behaviors are associated with anxiety maintenance and poorer treatment outcomes because they prevent fear extinction. Social anxiety disorder is often comorbid with stuttering. Speech pathologists reported in a…

  18. K Basin safety analysis

    Energy Technology Data Exchange (ETDEWEB)

    Porten, D.R.; Crowe, R.D.

    1994-12-16

    The purpose of this accident safety analysis is to document in detail, analyses whose results were reported in summary form in the K Basins Safety Analysis Report WHC-SD-SNF-SAR-001. The safety analysis addressed the potential for release of radioactive and non-radioactive hazardous material located in the K Basins and their supporting facilities. The safety analysis covers the hazards associated with normal K Basin fuel storage and handling operations, fuel encapsulation, sludge encapsulation, and canister clean-up and disposal. After a review of the Criticality Safety Evaluation of the K Basin activities, the following postulated events were evaluated: Crane failure and casks dropped into loadout pit; Design basis earthquake; Hypothetical loss of basin water accident analysis; Combustion of uranium fuel following dryout; Crane failure and cask dropped onto floor of transfer area; Spent ion exchange shipment for burial; Hydrogen deflagration in ion exchange modules and filters; Release of Chlorine; Power availability and reliability; and Ashfall.

  19. Formalizing Probabilistic Safety Claims

    Science.gov (United States)

    Herencia-Zapana, Heber; Hagen, George E.; Narkawicz, Anthony J.

    2011-01-01

    A safety claim for a system is a statement that the system, which is subject to hazardous conditions, satisfies a given set of properties. Following work by John Rushby and Bev Littlewood, this paper presents a mathematical framework that can be used to state and formally prove probabilistic safety claims. It also enables hazardous conditions, their uncertainties, and their interactions to be integrated into the safety claim. This framework provides a formal description of the probabilistic composition of an arbitrary number of hazardous conditions and their effects on system behavior. An example is given of a probabilistic safety claim for a conflict detection algorithm for aircraft in a 2D airspace. The motivation for developing this mathematical framework is that it can be used in an automated theorem prover to formally verify safety claims.

  20. The safety of domestic robotics: A survey of various safety-related publications

    NARCIS (Netherlands)

    Tadele, T.S.; de Vries, Theodorus J.A.; Stramigioli, Stefano

    Different branches of technology are striving to come up with new advancements that will enhance civilization and ultimately improve the quality of life. In the robotics community, strides have been made to bring the use of personal robots in office and home environments on the horizon. Safety is

  1. Patient safety education among chinese medical undergraduates: An empirical study.

    Science.gov (United States)

    Li, Gang; Tao, Hong-Bing; Liao, Jia-Zhi; Tang, Jin-Hui; Peng, Fang; Shu, Qin; Li, Wen-Gang; Tu, Shun-Gui; Chen, Zhuo

    2016-10-01

    education cannot change medical students' stereotyped cognition on matters related to patient safety, but it can effectively enhance their knowledge of laws and regulations of patient safety.

  2. Food Safety and Raw Milk

    Science.gov (United States)

    ... for Food Safety Get Ready to Grill Safely Protect Yourself When Eating Out Rules of the Game for Food Safety Safety Tips for Handling and Preparing Common Foods Steps to Safe and Healthy Fruits & Vegetables Social Media Graphics Food Safety Features Food Safety Newsletters Get ...

  3. Production supervisor impacts on subordinates' safety outcomes: an investigation of leader-member exchange and safety communication.

    Science.gov (United States)

    Michael, Judd H; Guo, Zhen George; Wiedenbeck, Janice K; Ray, Charles D

    2006-01-01

    Supervisors are increasingly important to the functioning of manufacturing operations, in large part due to their role as leaders. While supervisors' relations and communication with their subordinates are known to be important in influencing subordinates' behavior, little is known about how these two factors will impact subordinates' safety. This study investigated how much each factor contributes to safety-related outcomes for blue-collar production employees. Production employees at five Pennsylvania wood manufacturers completed a survey during their work shift. Five hundred and ninety eight employees provided data on leader-member exchange (LMX), safety communication, and safety-related events. Archival data on OSHA recordables were also obtained from the producers' human resources database. Analyses found that the influence of LMX was greater than that of safety communication in predicting safety-related events. Neither LMX nor safety communication was significantly related to OSHA recordables. Results also demonstrated that employee job satisfaction and demographic variables such as gender and age have safety implications. Results from this study further emphasize the importance of production supervisors and illustrate the potential role of leader-member exchange in enhancing workplace safety. Specifically, organizations should foster positive social exchange between their employees and supervisors and enhance the leadership qualities of supervisors to help reduce workplace injuries.

  4. Influencing Safety in Australian Agriculture and Fisheries.

    Science.gov (United States)

    McBain-Rigg, Kristin E; Franklin, Richard C; King, Jemma C; Lower, Tony

    2017-01-01

    Improving the health and safety of those working in Australian agriculture and fishery industries is a recognized priority area for preventative activities. With Australian agricultural industries being among the nation's most dangerous workplaces, there is a need for action. While there are currently known solutions, their implementation is limited. Influential agents, i.e., people who can influence others, are important for helping engender action to enact solutions into practice. This study examines agents that influence safety behavior either negatively (barriers) or positively (facilitators), in the Australian agriculture and fishery industries. Focus groups were conducted with producers and industry representatives. Thematic analysis identified barriers and facilitators to improve health and safety. These were assessed against the Socioecological Model, which considers the various, and often intersecting, human (intrapersonal, i.e. values and attitudes, peers, familial, and cultural) factors influencing safety behavior. Seven categories of human influences were identified: self, peers, family, intergenerational change, industry agents, government agents, and other. Peers (including direct managers) and family were seen to be direct influencers. Individuals signal to others that safety is valued and important. This is reinforced by experience, skill, attitudes, and behavior. Safety practice knowledge acquisition occurred via the family unit, specific training, industry, or knowledge transfer between industries. Government influence predominately focused on legislation and while the source of this influence is distant, it does influence behavior. There is a need to support comprehensive programs. These should include strengthening relationships via peer-to-peer networking, sharing information about safety initiatives, appropriate legislation, and enhancing leadership of all influencers with regard to safety.

  5. Culture matters: indigenizing patient safety in Bhutan.

    Science.gov (United States)

    Pelzang, Rinchen; Johnstone, Megan-Jane; Hutchinson, Alison M

    2017-09-01

    Studies show that if quality of healthcare in a country is to be achieved, due consideration must be given to the importance of the core cultural values as a critical factor in improving patient safety outcomes. The influence of Bhutan's traditional (core) cultural values on the attitudes and behaviours of healthcare professionals regarding patient care are not known. This study aimed to explore the possible influence of Bhutan's traditional cultural values on staff attitudes towards patient safety and quality care. Undertaken as a qualitative exploratory descriptive inquiry, a purposeful sample of 94 healthcare professionals and managers were recruited from three levels of hospitals, a training institute and the Ministry of Health. Interviews were transcribed verbatim and analysed using thematic analysis strategies. The findings of the study suggest that Bhutanese traditional cultural values have both productive and counterproductive influences on staff attitudes towards healthcare delivery and the processes that need to be in place to ensure patient safety. Productive influences encompassed: karmic incentives to avoid preventable harm and promote safe patient care; and the prospective adoption of the 'four harmonious friends' as a culturally meaningful frame for improving understanding of the role and importance of teamwork in enhancing patient safety. Counterproductive influences included: the adoption of hierarchical and authoritative styles of management; unilateral decision-making; the legitimization of karmic beliefs; differential treatment of patients; and preferences for traditional healing practices and rituals. Although problematic in some areas, Bhutan's traditional cultural values could be used positively to inform and frame an effective model for improving patient safety in Bhutan's hospitals. Such a model must entail the institution of an 'indigenized' patient safety program, with patient safety research and reporting systems framed around local

  6. Requirement and prospect of nuclear data activities for nuclear safety

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, Itsuro [Nuclear Safety System, Inc., Mihama, Fukui (Japan)

    2000-03-01

    Owing to continuous efforts by the members of JNDC (Japanese Nuclear Data Committee) and Nuclear Data Center in JAERI (Japan Atomic Energy Research Institute), several superb evaluated nuclear data files, such as JENDL, FP (fission product) yields and decay heat, have been compiled in Japan and opened to the world. However, they are seldom adopted in safety design and safety evaluation of light water reactors and are hardly found in related safety regulatory guidelines and standards except the decay heat. In this report, shown are a few examples of presently used nuclear data in the safety design and the safety evaluation of PWRs (pressurized water reactors) and so forth. And then, several procedures are recommended in order to enhance more utilization of Japanese evaluated nuclear data files for nuclear safety. (author)

  7. Safety insights from forensics evaluations at Daiichi

    Directory of Open Access Journals (Sweden)

    J. Rempe

    2017-01-01

    Information obtained from Daiichi is required to inform Decontamination and Decommissioning activities, improving the ability of the Tokyo Electric Power Company (TEPCO to characterize potential hazards and to ensure the safety of workers involved with cleanup activities. This paper reports initial results from the US Forensics Effort to utilize examination information obtained by TEPCO to enhance the safety of existing and future nuclear power plant designs. In this paper, three examples are presented in which examination information, such as visual images, dose surveys, sample evaluations, and muon tomography examinations, along with data from plant instrumentation, are used to obtain significant safety insights in the areas of component performance, fission product release and transport, debris end-state location, and combustible gas generation and transport. In addition to reducing uncertainties related to severe accident modeling progression, these insights confirm actions, such as the importance of water addition and containment venting, that are emphasized in updated guidance for severe accident prevention, mitigation, and emergency planning.

  8. Inherent Safety Characteristics of Advanced Fast Reactors

    Science.gov (United States)

    Bochkarev, A. S.; Korsun, A. S.; Kharitonov, V. S.; Alekseev, P. N.

    2017-01-01

    The study presents SFR transient performance for ULOF events initiated by pump trip and pump seizure with simultaneous failure of all shutdown systems in both cases. The most severe cases leading to the pin cladding rupture and possible sodium boiling are demonstrated. The impact of various features on SFR inherent safety performance for ULOF events was analysed. The decrease in hydraulic resistance of primary loop and increase in primary pump coast down time were investigated. Performing analysis resulted in a set of recommendations to varying parameters for the purpose of enhancing the inherent safety performance of SFR. In order to prevent the safety barrier rupture for ULOF events the set of thermal hydraulic criteria defining the ULOF transient processes dynamics and requirements to these criteria were recommended based on achieved results: primary sodium flow dip under the natural circulation asymptotic level and natural circulation rise time.

  9. A Study on the Holding Capacity Safety Factors for Torpedo Anchors

    Directory of Open Access Journals (Sweden)

    Luís V. S. Sagrilo

    2012-01-01

    Full Text Available The use of powerful numerical tools based on the finite-element method has been improving the prediction of the holding capacity of fixed anchors employed by the offshore oil industry. One of the main achievements of these tools is the reduction of the uncertainty related to the holding capacity calculation of these anchors. Therefore, it is also possible to reduce the values of the associated design safety factors, which have been calibrated relying on models with higher uncertainty, without impairing the original level of structural safety. This paper presents a study on the calibration of reliability-based safety factors for the design of torpedo anchors considering the statistical model uncertainty evaluated using results from experimental tests and their correspondent finite-element-based numerical predictions. Both working stress design (WSD and load and resistance factors design (LRFD design methodologies are investigated. Considering the WSD design methodology, the single safety is considerably lower than the value typically employed in the design of torpedo anchors. Moreover, a LRFD design code format for torpedo anchors is more appropriate since it leads to designs having less-scattered safety levels around the target value.

  10. Exploratory analysis of the safety climate and safety behavior relationship.

    Science.gov (United States)

    Cooper, M D; Phillips, R A

    2004-01-01

    Safety climate refers to the degree to which employees believe true priority is given to organizational safety performance, and its measurement is thought to provide an "early warning" of potential safety system failure(s). However, researchers have struggled over the last 25 years to find empirical evidence to demonstrate actual links between safety climate and safety performance. A safety climate measure was distributed to manufacturing employees at the beginning of a behavioral safety initiative and redistributed one year later. Multiple regression analysis demonstrated that perceptions of the importance of safety training were predictive of actual levels of safety behavior. The results also demonstrate that the magnitude of change in perceptual safety climate scores will not necessarily match actual changes (r=0.56, n.s.) in employee's safety behavior. This study obtained empirical links between safety climate scores and actual safety behavior. Confirming and contradicting findings within the extant safety climate literature, the results strongly suggest that the hypothesized climate-behavior-accident path is not as clear cut as commonly assumed. A statistical link between safety climate perceptions and safety behavior will be obtained when sufficient behavioral data is collected. The study further supports the use of safety climate measures as useful diagnostic tools in ascertaining employee's perceptions of the way that safety is being operationalized.

  11. Is Safety in Danger?

    DEFF Research Database (Denmark)

    Broncano-Berrocal, Fernando

    2014-01-01

    In “Knowledge Under Threat” (Philosophy and Phenomenological Research 2012), Tomas Bogardus proposes a counterexample to the safety condition for knowledge. Bogardus argues that the case demonstrates that unsafe knowledge is possible. I argue that the case just corroborates the well-known require...... offer a diagnosis of a common error about the kind of cases that are typically considered potential counterexamples to the necessity of the epistemic condition: proponents of the alleged counterexamples mistake a strong condition that I call super-safety for safety......In “Knowledge Under Threat” (Philosophy and Phenomenological Research 2012), Tomas Bogardus proposes a counterexample to the safety condition for knowledge. Bogardus argues that the case demonstrates that unsafe knowledge is possible. I argue that the case just corroborates the well......-known requirement that modal conditions like safety must be relativized to methods of belief formation. I explore several ways of relativizing safety to belief-forming methods and I argue that none is adequate: if methods were individuated in those ways, safety would fail to explain several much-discussed cases. I...

  12. Safety management practices and safety behaviour: assessing the mediating role of safety knowledge and motivation.

    Science.gov (United States)

    Vinodkumar, M N; Bhasi, M

    2010-11-01

    Safety management practices not only improve working conditions but also positively influence employees' attitudes and behaviours with regard to safety, thereby reducing accidents in workplace. This study measured employees' perceptions on six safety management practices and self-reported safety knowledge, safety motivation, safety compliance and safety participation by conducting a survey using questionnaire among 1566 employees belonging to eight major accident hazard process industrial units in Kerala, a state in southern part of India. The reliability and unidimesionality of all the scales were found acceptable. Path analysis using AMOS-4 software showed that some of the safety management practices have direct and indirect relations with the safety performance components, namely, safety compliance and safety participation. Safety knowledge and safety motivation were found to be the key mediators in explaining these relationships. Safety training was identified as the most important safety management practice that predicts safety knowledge, safety motivation, safety compliance and safety participation. These findings provide valuable guidance for researchers and practitioners for identifying the mechanisms by which they can improve safety of workplace. 2010 Elsevier Ltd. All rights reserved.

  13. Managing electrical safety

    CERN Document Server

    Wiggins, James H, Jr

    2001-01-01

    Managing Electrical Safety provides an overview of electric basics, hazards, and established standards that enables you to understand the hazards you are likely to encounter in your workplace. Focusing on typical industrial environments-which utilize voltages much higher than household or office circuits-the author identifies the eight key components of an electrical safety program and examines each using a model safety management process. You'll learn how to identify electrical hazards, how to prescribe necessary electrical Personal Protective Equipment, how to ensure that equipment is de-ene

  14. LTE for public safety

    CERN Document Server

    Liebhart, Rainer; Wong, Curt; Merkel , Jürgen

    2015-01-01

    The aim of the book is to educate government agencies, operators, vendors and other regulatory institutions how LTE can be deployed to serve public safety market and offer regulatory / public safety features. It is written in such a way that it can be understood by both technical and non-technical personnel with just introductory knowledge in wireless communication. Some sections and chapters about public safety services offered by LTE network are intended to be understood by anyone with no knowledge in wireless communication.

  15. Safety shutdown separators

    Science.gov (United States)

    Carlson, Steven Allen; Anakor, Ifenna Kingsley; Farrell, Greg Robert

    2015-06-30

    The present invention pertains to electrochemical cells which comprise (a) an anode; (b) a cathode; (c) a solid porous separator, such as a polyolefin, xerogel, or inorganic oxide separator; and (d) a nonaqueous electrolyte, wherein the separator comprises a porous membrane having a microporous coating comprising polymer particles which have not coalesced to form a continuous film. This microporous coating on the separator acts as a safety shutdown layer that rapidly increases the internal resistivity and shuts the cell down upon heating to an elevated temperature, such as 110.degree. C. Also provided are methods for increasing the safety of an electrochemical cell by utilizing such separators with a safety shutdown layer.

  16. Nuclear regulation and safety

    Energy Technology Data Exchange (ETDEWEB)

    Hendrie, J.M.

    1982-01-01

    Nuclear regulation and safety are discussed from the standpoint of a hypothetical country that is in the process of introducing a nuclear power industry and setting up a regulatory system. The national policy is assumed to be in favor of nuclear power. The regulators will have responsibility for economic, reliable electric production as well as for safety. Reactor safety is divided into three parts: shut it down, keep it covered, take out the afterheat. Emergency plans also have to be provided. Ways of keeping the core covered with water are discussed. (DLC)

  17. Systems Safety and Engineering Division

    Data.gov (United States)

    Federal Laboratory Consortium — Volpe's Systems Safety and Engineering Division conducts engineering, research, and analysis to improve transportation safety, capacity, and resiliency. We provide...

  18. Food Quality: Safety, Nutrition, and Labeling

    OpenAIRE

    Kramer, Carol S.; Caswell, Julie A.

    1993-01-01

    This paper discussed food quality issues associated with both food safety and food nutritional content. Policy approaches to satisfying consumer demands for safe, nutritious food are described from administrative as well as economic perspectives. Current priority issues include instituting better ways of reducing risks from microbial pathogens, from agricultural chemical residues, and ? on the nutritional front ? enhancing the nutritional profile of consumers' diets. Nutrition labeling change...

  19. Aeromedical solutions for aerospace safety.

    Science.gov (United States)

    Kapoor, Pawan; Gaur, Deepak

    2017-10-01

    All facets of activity in the speciality of Aviation Medicine are essentially aimed at enhancing aerospace safety. This paper highlights some innovative changes brought about by Aerospace Medicine in the three major fields of the speciality namely, medical evaluation, aeromedical training and research. Based on lab and field studies, military aircrew are now permitted flying with Modifinil as 'Go' Pill and Zolpidem as 'No-Go' Pill during sustained operations. Several other drugs for disabilities like Hypertension and CAD are now permitted for aviators. Comprehensive revision of policy permitting early return to flying is an on-going process. OPRAM courses for all three streams of aircrew in IAF have contributed to reduce aircraft accident rates. Human Engineering Consultancy and expert advice is provided by specialists at IAM as well as those in the field. In future, the country needs to provide better post-service opportunities to aerospace medicine specialists. This, in turn, will attract bright young minds to the specialty. The ISRO Humanin-Space programme will be an exciting challenge for all in this unique field. Aerospace Medicine continues to provide aerospace safety solutions to the IAF and the aviation industry. The nation needs to continue to utilize and support this specialty.

  20. Improving patient safety culture in general practice: an interview study.

    Science.gov (United States)

    Verbakel, Natasha J; de Bont, Antoinette A; Verheij, Theo J M; Wagner, Cordula; Zwart, Dorien L M

    2015-12-01

    When improving patient safety a positive safety culture is key. As little is known about improving patient safety culture in primary care, this study examined whether administering a culture questionnaire with or without a complementary workshop could be used as an intervention for improving safety culture. To gain insight into how two interventions affected patient safety culture in everyday practice. After conducting a randomised control trial of two interventions, this was a qualitative study conducted in 30 general practices to aid interpretation of the previous quantitative findings. Interviews were conducted at practice locations (n = 27) with 24 GPs and 24 practice nurses. The theory of communities of practice--in particular, its concepts of a domain, a community, and a practice--was used to interpret the findings by examining which elements were or were not present in the participating practices. Communal awareness of the problem was only raised after getting together and discussing patient safety. The combination of a questionnaire and workshop enhanced the interaction of team members and nourished team feelings. This shared experience also helped them to understand and develop tools and language for daily practice. In order for patient safety culture to improve, the safety culture questionnaire was more successful when accompanied by a practice workshop. Initial discussion and negotiation of shared goals during the workshop fuelled feelings of coherence and belonging to a community wishing to learn about enhancing patient safety. Team meetings and day-to-day interactions enhanced further liaison and sharing, making patient safety a common and conscious goal. © British Journal of General Practice 2015.

  1. MRI Safety during Pregnancy

    Science.gov (United States)

    ... News Physician Resources Professions Site Index A-Z MRI Safety During Pregnancy Magnetic resonance imaging (MRI) Illness ... during the exam? Contrast material MRI during pregnancy Magnetic resonance imaging (MRI) If you are pregnant and your doctor ...

  2. Carbon Monoxide Safety

    Science.gov (United States)

    ... 189 KB Public service announcement: winter fire safety Stock photography Use these free, high resolution photos to ... Twitter Facebook Twitter Fire Prevention and Public Education Exchange The Exchange is a collection of national, state ...

  3. Vaccine Safety Datalink

    Science.gov (United States)

    The Vaccine Safety Datalink is part of the National Immunization Program within the Centers for Disease Control and Prevention and was started in recognition of gaps in the scientific knowledge of rare vaccine side effects.

  4. Organizational Culture and Safety

    Science.gov (United States)

    Adams, Catherine A.

    2003-01-01

    '..only a fool perseveres in error.' Cicero. Humans will break the most advanced technological devices and override safety and security systems if they are given the latitude. Within the workplace, the operator may be just one of several factors in causing accidents or making risky decisions. Other variables considered for their involvement in the negative and often catastrophic outcomes include the organizational context and culture. Many organizations have constructed and implemented safety programs to be assimilated into their culture to assure employee commitment and understanding of the importance of everyday safety. The purpose of this paper is to examine literature on organizational safety cultures and programs that attempt to combat vulnerability, risk taking behavior and decisions and identify the role of training in attempting to mitigate unsafe acts.

  5. Laser safety in dentistry.

    Science.gov (United States)

    Sweeney, Caroline

    2008-01-01

    Although many regulations and standards relating to laser safety are in effect, there continue to be an average of 35 laser injuries per year. Laser safety professionals believe that this number under-represents the actual number of injuries and that many more accidents per year occur that are not documented with federal agencies. A review of these accidents has determined that failing to wear available eye protection is one of the most frequent contributing factors to laser injuries. As the purchase and use of lasers in dentistry continues to grow, so must concern for laser safety. This article provides basic information to advance the safe use of lasers in dentistry and to help establish laser safety protocols for the dental office.

  6. Injury & Safety Report - Legacy

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Injury & Safety Report is a mandatory post trip legal document observers fill out to report any injuries they have incurred, illnesses they have had, or...

  7. Winter Weather: Outdoor Safety

    Science.gov (United States)

    ... or Traumatic Event Resources for Families Resources for Leaders Resources for State and Local Governments Emergency Responders: ... Emergency Wound Care Wound Management for Healthcare Pros Power Outages When the Power Goes Out Worker Safety ...

  8. Winter Weather: Indoor Safety

    Science.gov (United States)

    ... or Traumatic Event Resources for Families Resources for Leaders Resources for State and Local Governments Emergency Responders: ... Emergency Wound Care Wound Management for Healthcare Pros Power Outages When the Power Goes Out Worker Safety ...

  9. Practice Hospital Bed Safety

    Science.gov (United States)

    ... Updates Practice Hospital Bed Safety Share Tweet Linkedin Pin it More sharing options Linkedin Pin it Email Print Hospital Bed Entrapment Zones An ... the side edge of the head or foot board 7. between the head or foot board and ...

  10. Aerospace Safety Advisory Panel

    Science.gov (United States)

    1984-01-01

    An assessment of NASA's safety performance for 1983 affirms that NASA Headquarters and Center management teams continue to hold the safety of manned flight to be their prime concern, and that essential effort and resources are allocated for maintaining safety in all of the development and operational programs. Those conclusions most worthy of NASA management concentration are given along with recommendations for action concerning; product quality and utility; space shuttle main engine; landing gear; logistics and management; orbiter structural loads, landing speed, and pitch control; the shuttle processing contractor; and the safety of flight operations. It appears that much needs to be done before the Space Transportation System can achieve the reliability necessary for safe, high rate, low cost operations.

  11. Swimming Pool Safety

    Science.gov (United States)

    ... Prevention Listen Español Text Size Email Print Share Swimming Pool Safety Page Content ​What is the best way to keep my child safe around swimming pools? An adult should actively watch children at ...

  12. Safety in paediatric imaging

    Energy Technology Data Exchange (ETDEWEB)

    Carter, D.; Filice, I.; Murray, D.; Thomas, K. [The Hospital for Sick Children, Toronto, Ontario (Canada)

    2006-01-01

    Those of us working in a dedicated paediatric environment are aware of the important safety issues with regard to paediatrics. Our goal when working with paediatric patients, the goal is to obtain the best quality images while keeping patients safe and their distress to a minimum. This article will discuss some of the issues regarding paediatric safety in a diagnostic imaging department, including radiation doses and the risk to paediatric patients, reducing medication errors, safe sedation practice and environmental safety. Also discussed are some conditions requiring special consideration to maintain patient safety such as epiglottitis and suspected child abuse. Promotion of a patient/family-centered care system will create an environment of trust where parents or guardians will know that their children are being well cared for in a safe, effective environment. (author)

  13. First Aid and Safety

    Science.gov (United States)

    ... Them Safely Preventing Dog Bites Selecting Safe Pets Sexting: What Parents Need to Know Taking Care of ... Vaccines Before Traveling? How to Choose & Use Sunscreen Sexting: What Parents Need to Know Printable Safety Guides ...

  14. Nanosensors for food safety.

    Science.gov (United States)

    Li, Zhixiong; Sheng, Chenxing

    2014-01-01

    This review summarizes recent research and development of nanosensors applied to the food safety. Since the food safety is directly related to the people's health and life, the food detection has received considerable attentions. However, this food security has emerged in China as a severe problem in recent years. Food safety problems frequently compromised due to formaldehyde, poison vegetables, excessive pesticide residues, etc. These kinds of food contaminations could not be detected efficiently by traditional methods. Applying nanotechnology and nanominerals, various food contaminations can be identified accurately. Therefore nanosensors have been widely used in the food detection. We introduce current research on nanosensors followed by the industrial application of nanosensors. Finally, the challenges for the future food safety using nanosensors are discussed.

  15. APPLIED FARM FOOD SAFETY

    OpenAIRE

    Ender, Judit; Mikaczo, Andrea

    2008-01-01

    Recently there have been more and more foodborne illnesses being associated with fresh vegetable produce. In response to this, consumer confidence has been lowered with the safety of the vegetable industry. So, many retailers have recently announced programs requiring growers to have independent third-party inspections. The goal with this essay is to introduce a vegetable farm and reveal its food safety procedures from the seeding through shipping,. reviewing, evaluating, and strengthening cu...

  16. Criticality safety training

    Energy Technology Data Exchange (ETDEWEB)

    Woodruff, S.K. [Los Alamos National Lab., NM (United States)

    1997-06-01

    Criticality safety training is an important element of the Plutonium Facility safety program at Los Alamos National Laboratory. Training consists of student self-study handbooks and hands-on performance-based training in a mock-up laboratory containing gloveboxes, trolley conveyor system, and self-monitoring instruments. A 10-minute video tape and lecture was presented to describe how training in this area is conducted.

  17. Safety Campaign Continues

    CERN Multimedia

    2002-01-01

    If you see this poster, stop and read it! This is the third poster produced by TIS Division as part of its information campaign on health and safety in the workplace. It provides statistics on occupational accidents at CERN. You will see that, as in the rest of Europe, falls, slips and trips continue to be the main cause of accident. So, eyes open and take care! For more information : http://safety.cern.ch/

  18. Magnetic Resonance Safety

    OpenAIRE

    Sammet, Steffen

    2016-01-01

    Magnetic Resonance Imaging (MRI) has a superior soft-tissue contrast compared to other radiological imaging modalities and its physiological and functional applications have led to a significant increase in MRI scans worldwide. A comprehensive MRI safety training to protect patients and other healthcare workers from potential bio-effects and risks of the magnetic fields in an MRI suite is therefore essential. The knowledge of the purpose of safety zones in an MRI suite as well as MRI appropri...

  19. Safety instruction No. 36

    CERN Multimedia

    SC Secretariat

    2005-01-01

    Please note that a revised version of Safety Instruction No. 36 (IS 36), entitled "Safety rules for the use of static magnetic fields at CERN" is available on the Web at the following url: https://edms.cern.ch/document/335801/LAST_RELEASED Paper copies can also be obtained from the SC unit secretariat (e-mail : sc.secretariat@cern.ch) SC Secretariat

  20. Software system safety

    Science.gov (United States)

    Uber, James G.

    1988-01-01

    Software itself is not hazardous, but since software and hardware share common interfaces there is an opportunity for software to create hazards. Further, these software systems are complex, and proven methods for the design, analysis, and measurement of software safety are not yet available. Some past software failures, future NASA software trends, software engineering methods, and tools and techniques for various software safety analyses are reviewed. Recommendations to NASA are made based on this review.

  1. Safety Culture in the Maternity Units: a census survey using the Safety Attitudes Questionnaire

    Directory of Open Access Journals (Sweden)

    Savva Nicos

    2011-09-01

    Full Text Available Abstract Background Patient safety has been a priority for many societies and health care systems in the last decades. Identification of preventable risks and aversion of potentially unsafe situations and fatal complications in maternity units is life saving. The explicit need to focus on quality of care underpins the aim of the study to initially evaluate the safety culture and teamwork climate in the public Maternity Units of the 5 Regional Hospitals in Cyprus as measured by a validated safety attitudes tool. Methods Data were collected from 140 midwives working in the public sector all over Cyprus by the Greek Version of the Safety Attitudes Questionnaire-Labor version. Results One hundred and six (75.71% registered midwives completed the questionnaire fully. The median of total work experience as a registered midwife was 3 years (IQR: 2-18.25; whereas the median of total working experience in the nursing and maternity units was 5 years (IQR: 2-21.75. Experienced midwives rated the following domains higher: team work, safety climate, job satisfaction and working conditions as opposed to the midwives with less experience. Additionally those with a longer working life in the current maternity units rated these domains higher: safety climate, job satisfaction and working conditions as opposed to the less experienced midwives. Conclusions The high mean total score on team work and safety climate in the more experienced group of midwives is a predominant finding for the maternity units of Cyprus. In Cyprus where facilities are small in size and midwives know each other, share more responsibility towards patient safety. It could be suggested that younger midwives need more support and teamwork practice to enhance the safety and teamwork climate towards self-confidence.

  2. Safety culture in the maternity units: a census survey using the Safety Attitudes Questionnaire.

    Science.gov (United States)

    Raftopoulos, Vasilios; Savva, Nicos; Papadopoulou, Maria

    2011-09-27

    Patient safety has been a priority for many societies and health care systems in the last decades. Identification of preventable risks and aversion of potentially unsafe situations and fatal complications in maternity units is life saving. The explicit need to focus on quality of care underpins the aim of the study to initially evaluate the safety culture and teamwork climate in the public Maternity Units of the 5 Regional Hospitals in Cyprus as measured by a validated safety attitudes tool. Data were collected from 140 midwives working in the public sector all over Cyprus by the Greek Version of the Safety Attitudes Questionnaire-Labor version. One hundred and six (75.71%) registered midwives completed the questionnaire fully. The median of total work experience as a registered midwife was 3 years (IQR: 2-18.25); whereas the median of total working experience in the nursing and maternity units was 5 years (IQR: 2-21.75). Experienced midwives rated the following domains higher: team work, safety climate, job satisfaction and working conditions as opposed to the midwives with less experience. Additionally those with a longer working life in the current maternity units rated these domains higher: safety climate, job satisfaction and working conditions as opposed to the less experienced midwives. The high mean total score on team work and safety climate in the more experienced group of midwives is a predominant finding for the maternity units of Cyprus. In Cyprus where facilities are small in size and midwives know each other, share more responsibility towards patient safety. It could be suggested that younger midwives need more support and teamwork practice to enhance the safety and teamwork climate towards self-confidence.

  3. Safety system status monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, J.R.; Morgenstern, M.H.; Rideout, T.H.; Cowley, P.J.

    1984-03-01

    The Pacific Northwest Laboratory has studied the safety aspects of monitoring the preoperational status of safety systems in nuclear power plants. The goals of the study were to assess for the NRC the effectiveness of current monitoring systems and procedures, to develop near-term guidelines for reducing human errors associated with monitoring safety system status, and to recommend a regulatory position on this issue. A review of safety system status monitoring practices indicated that current systems and procedures do not adequately aid control room operators in monitoring safety system status. This is true even of some systems and procedures installed to meet existing regulatory guidelines (Regulatory Guide 1.47). In consequence, this report suggests acceptance criteria for meeting the functional requirements of an adequate system for monitoring safety system status. Also suggested are near-term guidelines that could reduce the likelihood of human errors in specific, high-priority status monitoring tasks. It is recommended that (1) Regulatory Guide 1.47 be revised to address these acceptance criteria, and (2) the revised Regulatory Guide 1.47 be applied to all plants, including those built since the issuance of the original Regulatory Guide.

  4. Fuel safety research 1999

    Energy Technology Data Exchange (ETDEWEB)

    Uetsuka, Hiroshi (ed.) [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2000-07-01

    In April 1999, the Fuel Safety Research Laboratory was newly established as a result of reorganization of the Nuclear Safety Research Center, JAERI. The laboratory was organized by combining three laboratories, the Reactivity Accident Laboratory, the Fuel Reliability Laboratory, and a part of the Sever Accident Research Laboratory. Consequently, the Fuel Safety Research Laboratory is now in charge of all the fuel safety research in JAERI. Various types of experimental and analytical researches are conducted in the laboratory by using the unique facilities such as the Nuclear Safety Research Reactor (NSRR), the Japan Material Testing Reactor (JMTR), the Japan Research Reactor 3 (JRR-3) and hot cells in JAERI. The laboratory consists of five research groups corresponding to each research fields. They are; (a) Research group of fuel behavior under the reactivity initiated accident conditions (RIA group). (b) Research group of fuel behavior under the loss-of-coolant accident conditions (LOCA group). (c) Research group of fuel behavior under the normal operation conditions (JMTR/BOCA group). (d) Research group of fuel behavior analysis (FEMAXI group). (e) Research group of FP release/transport behavior from irradiated fuel (VEGA group). This report summarizes the outline of research activities and major outcomes of the research executed in 1999 in the Fuel Safety Research Laboratory. (author)

  5. Safety Basis Report

    Energy Technology Data Exchange (ETDEWEB)

    R.J. Garrett

    2002-01-14

    As part of the internal Integrated Safety Management Assessment verification process, it was determined that there was a lack of documentation that summarizes the safety basis of the current Yucca Mountain Project (YMP) site characterization activities. It was noted that a safety basis would make it possible to establish a technically justifiable graded approach to the implementation of the requirements identified in the Standards/Requirements Identification Document. The Standards/Requirements Identification Documents commit a facility to compliance with specific requirements and, together with the hazard baseline documentation, provide a technical basis for ensuring that the public and workers are protected. This Safety Basis Report has been developed to establish and document the safety basis of the current site characterization activities, establish and document the hazard baseline, and provide the technical basis for identifying structures, systems, and components (SSCs) that perform functions necessary to protect the public, the worker, and the environment from hazards unique to the YMP site characterization activities. This technical basis for identifying SSCs serves as a grading process for the implementation of programs such as Conduct of Operations (DOE Order 5480.19) and the Suspect/Counterfeit Items Program. In addition, this report provides a consolidated summary of the hazards analyses processes developed to support the design, construction, and operation of the YMP site characterization facilities and, therefore, provides a tool for evaluating the safety impacts of changes to the design and operation of the YMP site characterization activities.

  6. Cryogenic safety organisation at CERN

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    With Safety being a top priority of CERN’s general policy, the Organisation defines and implements a Policy that sets out the general principles governing Safety at CERN. To the end of the attainment of said Safety objectives, the organic units (owners/users of the equipment) are assigned the responsibility for the implementation of the CERN Safety Policy at all levels of the organization, whereas the Health and Safety and Environmental Protection Unit (HSE) has the role of providing assistance for the implementation of the Safety Policy, and a monitoring role related to the implementation of continuous improvement of Safety, compliance with the Safety Rules and the handling of emergency situations. This talk will elaborate on the roles, responsibilities and organisational structure of the different stakeholders within the Organization with regards to Safety, and in particular to cryogenic safety. The roles of actors of particular importance such as the Cryogenic Safety Officers (CSOs) and the Cryogenic Sa...

  7. Leadership for safety: industrial experience.

    Science.gov (United States)

    Flin, R; Yule, S

    2004-12-01

    The importance of leadership for effective safety management has been the focus of research attention in industry for a number of years, especially in energy and manufacturing sectors. In contrast, very little research into leadership and safety has been carried out in medical settings. A selective review of the industrial safety literature for leadership research with possible application in health care was undertaken. Emerging findings show the importance of participative, transformational styles for safety performance at all levels of management. Transactional styles with attention to monitoring and reinforcement of workers' safety behaviours have been shown to be effective at the supervisory level. Middle managers need to be involved in safety and foster open communication, while ensuring compliance with safety systems. They should allow supervisors a degree of autonomy for safety initiatives. Senior managers have a prime influence on the organisation's safety culture. They need to continuously demonstrate a visible commitment to safety, best indicated by the time they devote to safety matters.

  8. Safety Learning, Organizational Contradictions and the Dynamics of Safety Practice

    Science.gov (United States)

    Ripamonti, Silvio Carlo; Scaratti, Giuseppe

    2015-01-01

    Purpose: The purpose of this paper is to explore the enactment of safety routines in a transshipment port. Research on work safety and reliability has largely neglected the role of the workers' knowledge in practice in the enactment of organisational safety. The workers' lack of compliance with safety regulations represents an enduring problem…

  9. Safety Culture and Senior Leadership Behavior: Using Negative Safety Ratings to Align Clinical Staff and Senior Leadership.

    Science.gov (United States)

    O'Connor, Shawn; Carlson, Elizabeth

    2016-04-01

    This report describes how staff-designed behavior changes among senior leaders can have a positive impact on clinical nursing staff and enhance the culture of safety in a community hospital. A positive culture of safety in a hospital improves outcomes for patients and staff. Senior leaders are accountable for developing an environment that supports a culture of safety. At 1 community hospital, surveys demonstrated that staff members did not view senior leaders as supportive of or competent in creating a culture of safety. After approval from the hospital's institutional review board was obtained, clinical nurses generated and selected ideas for senior leader behavior change. The new behaviors were assessed by a convenience sample survey of clinical nurses. In addition, culture of safety survey results were compared. Risk reports and harm events were also measured before and after behavior changes. The volume of risk and near-miss reports increased, showing that clinical staff were more inclined to report events after senior leader communication, access, and visibility increased. Harm events went down. The culture of safety survey demonstrated an improvement in the senior leadership domain in 4 of 6 units. The anonymous convenience survey demonstrated that staff members recognized changes that senior leaders had made and felt that these changes positively impacted the culture of safety. By developing skills in communication, advocacy, visibility, and access, senior leaders can enhance a hospital's culture of safety and create stronger ties with clinical staff.

  10. Labor unions and safety climate: perceived union safety values and retail employee safety outcomes.

    Science.gov (United States)

    Sinclair, Robert R; Martin, James E; Sears, Lindsay E

    2010-09-01

    Although trade unions have long been recognized as a critical advocate for employee safety and health, safety climate research has not paid much attention to the role unions play in workplace safety. We proposed a multiple constituency model of workplace safety which focused on three central safety stakeholders: top management, ones' immediate supervisor, and the labor union. Safety climate research focuses on management and supervisors as key stakeholders, but has not considered whether employee perceptions about the priority their union places on safety contributes contribute to safety outcomes. We addressed this gap in the literature by investigating unionized retail employee (N=535) perceptions about the extent to which their top management, immediate supervisors, and union valued safety. Confirmatory factor analyses demonstrated that perceived union safety values could be distinguished from measures of safety training, workplace hazards, top management safety values, and supervisor values. Structural equation analyses indicated that union safety values influenced safety outcomes through its association with higher safety motivation, showing a similar effect as that of supervisor safety values. These findings highlight the need for further attention to union-focused measures related to workplace safety as well as further study of retail employees in general. We discuss the practical implications of our findings and identify several directions for future safety research. 2009 Elsevier Ltd. All rights reserved.

  11. Perceived safety management practices in the logistics sector.

    Science.gov (United States)

    Auyong, Hui-Nee; Zailani, Suhaiza; Surienty, Lilis

    2016-03-09

    Malaysia's progress on logistics has been slowed to keep pace with its growth in trade. The Government has been pressing companies to improve the safety of their activities in order to reduce society's loss due to occupational accidents and illnesses. Occupational safety and health is a crucial part of a workplace because every worker has to take care of his/her own safety and health. The main occupational safety and health (OSH) national policy in Malaysia is the enactment of the Occupational Safety and Health Act (OSHA) 1994. Only those companies which have excellent health and safety care have good quality and productive employees. This study investigated safety management practices in the logistics sector. The present study is concerned with the human factors to safety in the logistics industry. The authors examined the perceived safety management practices of workers in the logistics sector. The purpose was to identify the perception of safety management practices of Malaysian logistics personnel. Survey questionnaires were distributed to assess logistics personnel about management commitment. The quantitative method using the availability sampling method was applied. The data gathered from the survey were analysed using SPSS software. The responses to the survey were rated according to the Likert scale type, with '1' indicating strongly disagree and '5' indicating strongly agree. One hundred and three employees of logistics functions completed the survey. The highest mean scores were found for fire apparatus, prioritisation of safety, and safety policy. The results from this study also emphasise the importance of the management's commitment in enhancing workplace safety. Specifically, companies should maintain good relations between the employer and the employee to help reduce workplace injuries.

  12. Relationship of hospital organizational culture to patient safety climate in the Veterans Health Administration.

    Science.gov (United States)

    Hartmann, Christine W; Meterko, Mark; Rosen, Amy K; Shibei Zhao; Shokeen, Priti; Singer, Sara; Gaba, David M

    2009-06-01

    Improving safety climate could enhance patient safety, yet little evidence exists regarding the relationship between hospital characteristics and safety climate. This study assessed the relationship between hospitals' organizational culture and safety climate in Veterans Health Administration (VA) hospitals nationally. Data were collected from a sample of employees in a stratified random sample of 30 VA hospitals over a 6-month period (response rate = 50%; n = 4,625). The Patient Safety Climate in Healthcare Organizations (PSCHO) and the Zammuto and Krakower surveys were used to measure safety climate and organizational culture, respectively. Higher levels of safety climate were significantly associated with higher levels of group and entrepreneurial cultures, while lower levels of safety climate were associated with higher levels of hierarchical culture. Hospitals could use these results to design specific interventions aimed at improving safety climate.

  13. Tip enhancement

    CERN Document Server

    Kawata, Satoshi

    2007-01-01

    This book discusses the recent advances in the area of near-field Raman scattering, mainly focusing on tip-enhanced and surface-enhanced Raman scattering. Some of the key features covered here are the optical structuring and manipulations, single molecule sensitivity, analysis of single-walled carbon nanotubes, and analytic applications in chemistry, biology and material sciences. This book also discusses the plasmonic materials for better enhancement, and optical antennas. Further, near-field microscopy based on second harmonic generation is also discussed. Chapters have been written by some of the leading scientists in this field, who present some of their recent work in this field.·Near-field Raman scattering·Tip-enhanced Raman spectroscopy·Surface-enhanced Raman spectroscopy·Nano-photonics·Nanoanalysis of Physical, chemical and biological materials beyond the diffraction limits·Single molecule detection

  14. Nuclear Safety Charter; Charte Surete Nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    The AREVA 'Values Charter' reaffirmed the priority that must be given to the requirement for a very high level of safety, which applies in particular to the nuclear field. The purpose of this Nuclear Safety Charter is to set forth the group's commitments in the field of nuclear safety and radiation protection so as to ensure that this requirement is met throughout the life cycle of the facilities. It should enable each of us, in carrying out our duties, to commit to this requirement personally, for the company, and for all stakeholders. These commitments are anchored in organizational and action principles and in complete transparency. They build on a safety culture shared by all personnel and maintained by periodic refresher training. They are implemented through Safety, Health, and Environmental management systems. The purpose of these commitments, beyond strict compliance with the laws and regulations in force in countries in which we operate as a group, is to foster a continuous improvement initiative aimed at continually enhancing our overall performance as a group. Content: 1 - Organization: responsibility of the group's executive management and subsidiaries, prime responsibility of the operator, a system of clearly defined responsibilities that draws on skilled support and on independent control of operating personnel, the general inspectorate: a shared expertise and an independent control of the operating organization, an organization that can be adapted for emergency management. 2 - Action principles: nuclear safety applies to every stage in the plant life cycle, lessons learned are analyzed and capitalized through the continuous improvement initiative, analyzing risks in advance is the basis of Areva's safety culture, employees are empowered to improve nuclear Safety, the group is committed to a voluntary radiation protection initiative And a sustained effort in reducing waste and effluent from facility Operations, employees and

  15. Software Safety Risk in Legacy Safety-Critical Computer Systems

    Science.gov (United States)

    Hill, Janice L.; Baggs, Rhoda

    2007-01-01

    Safety Standards contain technical and process-oriented safety requirements. Technical requirements are those such as "must work" and "must not work" functions in the system. Process-Oriented requirements are software engineering and safety management process requirements. Address the system perspective and some cover just software in the system > NASA-STD-8719.13B Software Safety Standard is the current standard of interest. NASA programs/projects will have their own set of safety requirements derived from the standard. Safety Cases: a) Documented demonstration that a system complies with the specified safety requirements. b) Evidence is gathered on the integrity of the system and put forward as an argued case. [Gardener (ed.)] c) Problems occur when trying to meet safety standards, and thus make retrospective safety cases, in legacy safety-critical computer systems.

  16. Preoperative Safety Briefing Project.

    Science.gov (United States)

    Defontes, James; Surbida, Stephanie

    2004-01-01

    Increased media attention on surgical procedures that were performed on the wrong anatomic site or wrong patient has prompted the health care industry to identify and address human factors that lead to medical errors. To increase patient safety in the perioperative setting, our objective was to create a climate of improved communication, collaboration, team-work, and situational awareness while the surgical team reviewed pertinent information about the patient and the pending procedure. A team of doctors, nurses, and technicians used human factors principles to develop the Preoperative Safety Briefing for use by surgical teams, a briefing similar to the preflight checklist used by the airline industry. A six-month pilot of the briefing began in the Kaiser Permanente (KP) Anaheim Medical Center in February 2002. Four indicators of safety culture were used to measure success of the pilot: occurrence of wrong-site/wrong procedures, attitudinal survey data, near-miss reports, and nursing personnel turnover data. Wrong-site surgeries decreased from 3 to 0 (300%) per year; employee satisfaction increased 19%; nursing personnel turnover decreased 16%; and perception of the safety climate in the operating room improved from "good" to "outstanding." Operating suite personnel perception of teamwork quality improved substantially. Operating suite personnel perception of patient safety as a priority, of personnel communication, of their taking responsibility for patient safety, of nurse input being well received, of overall morale, and of medical errors being handled appropriately also improved substantially. Team members who work together and communicate well can quickly detect and more easily avoid errors. The Preoperative Safety Briefing is now standard in many operating suites in the KP Orange County Service Area. The concepts and design of this project are transferable, and similar projects are underway in the Departments of Radiology and of Labor and Delivery at KP

  17. NSTA Portal to Science Safety

    Science.gov (United States)

    Roy, Ken

    2010-01-01

    The National Science Teachers Association's (NSTA) Science Safety Advisory Board recently launched the Safety in the Science Classroom portal. This portal serves as a gateway to safety resources for teachers, supervisors, and administrators. It also contains an evolving list of safety resources for elementary, middle, and high schools. The list…

  18. Safe Model Predictive Control Formulations Ensuring Process Operational Safety

    OpenAIRE

    Albalawi, Fahad Ali

    2017-01-01

    Model predictive control (MPC) is an advanced control strategy widely used in the process industries and beyond. Therefore, industry is interested in the development of MPC formulations that can enhance safety, reliability, and economic profitability of chemical processes. Motivated by these considerations, this dissertation focuses on the development of methods for integrating process operational safety and process economics within model predictive control system designs. To accomplish these...

  19. Bricks-and-mortar and patient safety culture.

    Science.gov (United States)

    Brandis, Susan; Schleimer, Stephanie; Rice, John

    2017-06-19

    Purpose Building a new hospital requires a major investment in capital infrastructure. The purpose of this paper is to investigate the impact of bricks-and-mortar on patient safety culture before and two years after the move of a large tertiary hospital to a greenfield site. The difference in patient safety perceptions between clinical and non-clinical staff is also explored. Design/methodology/approach This research uses data collected from the same workforce across two time periods (2013 and 2015) in a large Australian healthcare service. Validated surveys of patient safety culture ( n=306 and 246) were analysed using descriptive and inferential statistics. Findings Using two-way analysis of variance, the authors found that perceived patient safety culture remains unchanged for staff despite a major relocation and upgrade of services and different perceptions of patient safety culture between staff groups remains the same throughout change. Practical implications A dramatic change in physical context, such as moving an entire hospital, made no measurable impact on perceived patient safety culture by major groups of staff. Improving patient safety culture requires more than investment in buildings and infrastructure. Understanding differences in professional perspectives of patient safety culture may inform organisational management approaches, and enhance the targeting of specific strategies. Originality/value The authors believe this to be the first empirically based paper that investigates the impact of a large investment into hospital capital and a subsequent relocation of services on clinical and non-clinical staff perceptions of patient safety culture.

  20. [Should we establish patient safety leadership walkrounds? A systematic review].

    Science.gov (United States)

    Girerd-Genessay, I; Michel, P

    2015-10-01

    Used for over a decade, patient safety leadership walkrounds (PSLWs) is a managerial method designed to enhance the implementation of safety measures in hospitals. In order to determine the effect of PSLWs in French hospitals, we reviewed the literature on participant perceptions and the impact of PSLW on the overall culture of safety. We conducted a systematic review of articles assessing the impact of PSLWs on the culture of safety (comparative studies) or the perceptions of caregivers and managers (qualitative studies). Five studies investigating safety culture and three studies investigating participant perception were identified. PSLWs were associated with an improvement in safety culture and the overall safety climate. The presence of caregivers during the PSLWs was important to achieve improvement. PSLWs improved the dialogue between caregivers and managers, and improved knowledge on care safety. Some problems concerning managerial PSLW attendance and counter-productive attitudes have occasionally been reported. PSLWs improve safety culture. Their effectiveness depends on the way they are implemented. They should initially be tested in France to ensure their feasibility and acceptability in our healthcare system. Copyright © 2015 Elsevier Masson SAS. All rights reserved.