WorldWideScience

Sample records for relevant environmental factors

  1. Sources of Data and Expertise for Environmental Factors Relevant to Amphibious Operations

    National Research Council Canada - National Science Library

    Andrew, Colin

    2000-01-01

    .... Before embarking on a research program it seemed worthwhile to survey the institutions and personnel who already have expertise in the gathering and analysis of relevant environmental data types...

  2. META-ANALYSIS OF THE LIFE STYLE FACTORS RELEVANT TO ENVIRONMENTAL HAZARDS FOR THE AGING POPULATION

    Science.gov (United States)

    The goal of this U.S. Environmental Protection Agency (EPA) study is to characterize activity patterns, physiological changes, and environmental exposures for the aging population. Meta analysis was performed on more than 2000 reviewed articles to evaluate the lifestyle factors ...

  3. Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease

    NARCIS (Netherlands)

    Wiersinga, Wilmar M.

    2016-01-01

    Genetic factors contribute for about 70% to 80% and environmental factors for about 20% to 30% to the pathogenesis of autoimmune thyroid disease (AITD). Relatives of AITD patients carry a risk to contract AITD themselves. The 5-year risk can be quantified by the so-called Thyroid Events

  4. Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease

    OpenAIRE

    Wiersinga, Wilmar M.

    2016-01-01

    Genetic factors contribute for about 70% to 80% and environmental factors for about 20% to 30% to the pathogenesis of autoimmune thyroid disease (AITD). Relatives of AITD patients carry a risk to contract AITD themselves. The 5-year risk can be quantified by the so-called Thyroid Events Amsterdam-score, based on serum thyroid-stimulating hormone, thyroid peroxidase (TPO)-antibodies and family history. Subjects at risk may ask what they can do to prevent development of AITD. This review summar...

  5. Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease

    Directory of Open Access Journals (Sweden)

    Wilmar M. Wiersinga

    2016-06-01

    Full Text Available Genetic factors contribute for about 70% to 80% and environmental factors for about 20% to 30% to the pathogenesis of autoimmune thyroid disease (AITD. Relatives of AITD patients carry a risk to contract AITD themselves. The 5-year risk can be quantified by the so-called Thyroid Events Amsterdam-score, based on serum thyroid-stimulating hormone, thyroid peroxidase (TPO-antibodies and family history. Subjects at risk may ask what they can do to prevent development of AITD. This review summarizes what is known about modulation of exposure to environmental factors in terms of AITD prevention. To stop smoking decreases the risk on Graves disease but increases the risk on Hashimoto disease. Moderate alcohol intake provides some protection against both Graves and Hashimoto disease. Low selenium intake is associated with a higher prevalence of thyroid autoimmunity, but evidence that selenium supplementation may lower TPO antibodies and prevent subclinical hypothyroidism remains inconclusive. Low serum vitamin D levels are associated with a higher prevalence of TPO antibodies, but intervention studies with extra vitamin D have not been done yet. Stress may provoke Graves hyperthyroidism but not Hashimoto thyroiditis. Estrogen use have been linked to a lower prevalence of Graves disease. The postpartum period is associated with an increased risk of AITD. Taking together, preventive interventions to diminish the risk of AITD are few, not always feasible, and probably of limited efficacy.

  6. Changing Environmentally Relevant Behaviour.

    Science.gov (United States)

    Gudgion, T. J.; Thomas, M. Pugh

    1991-01-01

    Considered is the role of psychology in helping to change those human behaviors which have deleterious environmental effects. The foremost conclusion is that behavioral psychology can offer practical techniques for such change, yet there are indications that enduring behaviors may be better realized through the intrinsic motivation maintained by…

  7. Sources of Data and Expertise for Environmental Factors Relevant to Amphibious Operations

    National Research Council Canada - National Science Library

    Andrew, Colin

    2000-01-01

    In the planning and conduct of amphibious operations it is necessary to have knowledge of a range of environmental variables, such as sea states, surf zone width and wave heights, beach composition, and bathymetry...

  8. Gas-phase organics in environmental tobacco smoke: 2. Exposure-relevant emission factors and indirect exposures from habitual smoking

    Science.gov (United States)

    Singer, Brett C.; Hodgson, Alfred T.; Nazaroff, William W.

    Sorption of emitted gas-phase organic compounds onto material surfaces affects environmental tobacco smoke (ETS) composition and exposures indoors. We have introduced a new metric, the exposure relevant emission factor (EREF) that accounts for sorptive uptake and reemission to give the mass of individual ETS constituents available for exposure over a day in which smoking occurs. This paper describes month-long experiments to investigate sorption effects on EREFs and potential ETS exposures under habitual smoking conditions. Cigarettes were smoked in a 50-m 3 furnished room over a 3-h period 6-7 days per week, with continuous ventilation at 0.3, 0.6, or 2.1 h -1. Organic gas concentrations were measured every few days over 4-h "smoking", 10-h "post-smoking" and 10-h "background" periods. Concentration patterns of volatile ETS components including 1,3-butadiene, benzene and acrolein were similar to those calculated for a theoretical non-sorbing tracer, indicating limited sorption. Concentrations of ETS tracers, e.g. 3-ethenylpyridine (3-EP) and nicotine, and lower volatility toxic air contaminants including phenol, cresols, and naphthalene increased as experiments progressed, indicating mass accumulation on surfaces and higher desorption rates. Daily patterns stabilized after week 2, yielding a steady daily cycle of ETS concentrations associated with habitual smoking. EREFs for sorbing compounds were higher under steady cycle versus single-day smoking conditions by ˜50% for 3-EP, and by 2-3 times for nicotine, phenol, cresols, naphthalene, and methylnaphthalenes. Our results provide relevant information about potential indirect exposures from residual ETS (non-smoker enters room shortly after smoker finishes) and from reemission, and their importance relative to direct exposures (non-smoker present during smoking). Under the conditions examined, indirect exposures accounted for a larger fraction of total potential exposures for sorbing versus non-sorbing compounds

  9. (CALIFORNIA) META-ANALYSIS OF THE LIFE STYLE FACTORS RELEVANT TO ENVIRONMENTAL HAZARDS FOR THE AGING POPULATION

    Science.gov (United States)

    The goal of this U.S. Environmental Protection Agency (EPA) Aging Initiative study is to characterize activity patterns, physiological changes, and environmental exposures for the aging population. Meta-analysis was performed on more than 2000 reviewed articles to evaluate the l...

  10. Use of International Classification of Functioning, Disability and Health (ICF) to describe patient-reported disability in multiple sclerosis and identification of relevant environmental factors.

    Science.gov (United States)

    Khan, Fary; Pallant, Julie F

    2007-01-01

    To use the International Classification of Functioning, Disability and Health (ICF) to describe patient-reported disability in multiple sclerosis and identify relevant environmental factors. Cross-sectional survey of 101 participants in the community. Their multiple sclerosis-related problems were linked with ICF categories (second level) using a checklist, consensus between health professionals and the "linking rules". The impact of multiple sclerosis on health areas corresponding to 48 ICF categories was also assessed. A total of 170 ICF categories were identified (mean age 49 years, 72 were female). Average number of problems reported was 18. The categories include 48 (42%) for body function, 16 (34%) body structure, 68 (58%) activities and participation and 38 (51%) for environmental factors. Extreme impact in health areas corresponding to ICF categories for activities and participation were reported for mobility, work, everyday home activities, community and social activities. While those for the environmental factors (barriers) included products for mobility, attitudes of extended family, restriction accessing social security and health resources. This study is a first step in the use of the ICF in persons with multiple sclerosis and towards development of the ICF Core set for multiple sclerosis from a broader international perspective.

  11. Prenatal immune challenge is an environmental risk factor for brain and behavior change relevant to schizophrenia: evidence from MRI in a mouse model.

    Directory of Open Access Journals (Sweden)

    Qi Li

    Full Text Available OBJECTIVES: Maternal infection during pregnancy increases risk of severe neuropsychiatric disorders, including schizophrenia and autism, in the offspring. The most consistent brain structural abnormality in patients with schizophrenia is enlarged lateral ventricles. However, it is unknown whether the aetiology of ventriculomegaly in schizophrenia involves prenatal infectious processes. The present experiments tested the hypothesis that there is a causal relationship between prenatal immune challenge and emergence of ventricular abnormalities relevant to schizophrenia in adulthood. METHOD: We used an established mouse model of maternal immune activation (MIA by the viral mimic PolyI:C administered in early (day 9 or late (day 17 gestation. Automated voxel-based morphometry mapped cerebrospinal fluid across the whole brain of adult offspring and the results were validated by manual region-of-interest tracing of the lateral ventricles. Parallel behavioral testing determined the existence of schizophrenia-related sensorimotor gating abnormalities. RESULTS: PolyI:C-induced immune activation, in early but not late gestation, caused marked enlargement of lateral ventricles in adulthood, without affecting total white and grey matter volumes. This early exposure disrupted sensorimotor gating, in the form of prepulse inhibition. Identical immune challenge in late gestation resulted in significant expansion of 4(th ventricle volume but did not disrupt sensorimotor gating. CONCLUSIONS: Our results provide the first experimental evidence that prenatal immune activation is an environmental risk factor for adult ventricular enlargement relevant to schizophrenia. The data indicate immune-associated environmental insults targeting early foetal development may have more extensive neurodevelopmental impact than identical insults in late prenatal life.

  12. The value relevance of environmental emissions

    Directory of Open Access Journals (Sweden)

    Melinda Lydia Nelwan

    2016-07-01

    Full Text Available This study examines whether environmental performance has value relevance by investigating the relations between environmental emissions and stock prices for the U.S. public companies. The previous studies argued that the conjectured relations between accounting performance measures and environmental performance do not have a strong theoretical basis, and the modeling of relations between market per-formance measures and environmental performance do not adequately consider the relevance of accounting performance to market value. Therefore, this study examines whether publicly reported environmental emissions provide incremental information to accounting earnings in pricing companies stocks. It is done among the complete set of industries covered by Toxics Release Inventory (TRI reporting for the period 2007 to 2010. Using Ohlson model but modified to include different types of emis-sions, it is found that ground emissions (underground injection and land emissions are value relevant but other emission types (air and water and transferred-out emis-sions appear to not provide incremental information in the valuation model. The result in this study raise concerns that different types of emissions are assessed differently by the market, confirming that studies should not aggregate such measures.

  13. Ligand Exchange Kinetics of Environmentally Relevant Metals

    Energy Technology Data Exchange (ETDEWEB)

    Panasci, Adele Frances [Univ. of California, Davis, CA (United States)

    2014-07-15

    The interactions of ground water with minerals and contaminants are of broad interest for geochemists but are not well understood. Experiments on the molecular scale can determine reaction parameters (i.e. rates of ligand exchange, activation entropy, activation entropy, and activation volume) that can be used in computations to gain insight into reactions that occur in natural groundwaters. Experiments to determine the rate of isotopic ligand exchange for three environmentally relevant metals, rhodium (Rh), iron (Fe), and neptunium (Np), are described. Many environmental transformations of metals (e.g. reduction) in soil occur at trivalent centers, Fe(III) in particular. Contaminant ions absorb to mineral surfaces via ligand exchange, and the reversal of this reaction can be dangerous, releasing contaminants into the environment. Ferric iron is difficult to study spectroscopically because most of its complexes are paramagnetic and are generally reactive toward ligand exchange; therefore, Rh(III), which is diamagnetic and less reactive, was used to study substitution reactions that are analogous to those that occur on mineral oxide surfaces. Studies on both Np(V) and Np(VI) are important in their own right, as 237Np is a radioactive transuranic element with a half-life of 2 million years.

  14. Thermochemical data for environmentally-relevant elements

    International Nuclear Information System (INIS)

    Markich, S.J.; Brown, P.L.

    1999-01-01

    This study provides an extensive stability constant (log K) database suitable for calculating the speciation of selected environmentally-relevant elements (H, Na, K, Ca, Mg, Fe, Mn, U, Al Pb, Zn, Cu and cd) in an aqueous system, where a model fulvic acid (comprising aspartic, citric, malonic, salicylic and tricarballylic acids) is used to simulate metal binding by dissolved organic material Stability constants for inorganic metal complexes and minerals were selected primarily from critical literature complications and/or reviews. In contrast, few critically evaluated data were available for metal complexes with aspartic, citric, malonic, salicylic and tricarballylic acids. Consequently, data from original research articles were carefully evaluated and compiled as part of the study, following defined selection criteria. to meet the objective of compiling a comprehensive and reliable database of stability constants, all relevant equilibria and species, ranging from simple binary metal complexes to more complex ternary and even quaternary, metal complexes were included where possible in addition to the selection of stability constants from empirical sources, estimates of stability constants were performed when this could be done reliably, based on the unified theory of metal ion complexation and/or linear tree energy relationships The stability constants are given as common logarithms (logo) in the form required by the HARPHRQ geochemical code and refer to the standard state, i.e 298.15 K (25 deg C), 10 5 Pa (1 atm) and, for all species, infinite dilution (ionic strength = 0 mol L -1 ). In addition to the compilation of stability constant data, an overview is given of geochemical speciation modelling in aqueous systems and available conceptual models of metal binding by humic substances. (authors)

  15. How relevant is the deposition of mercury onto snowpacks? – Part 1: A statistical study on the impact of environmental factors

    Directory of Open Access Journals (Sweden)

    K. A. Pfaffhuber

    2012-10-01

    precipitation. Mercury deposited through wet processes is more strongly retained by snowpacks than mercury deposited through dry processes. Revolatilization of mercury deposited through wet processes may be inhibited through burial by fresh snowfalls and/or by its more central location, compared to that of mercury deposited through dry deposition, within snowpack snow grains. The two depositions of oxidized mercury together explain 84% of the variability in observed concentrations of mercury in surface snow, 52% of the variability of observed concentrations of mercury in seasonal snowpacks and their meltwater's ionic pulse, and only 20% of the variability of observed concentrations of mercury in long-term snowpack-related records; other environmental controls seemingly gain in relevance as time passes. The concentration of mercury in long-term records is apparently primarily affected by latitude; both the primary sources of anthropogenic mercury and the strong upper-level zonal winds are located in the midlatitudes.

  16. Functional dyspepsia: Are psychosocial factors of relevance?

    Institute of Scientific and Technical Information of China (English)

    Sandra Barry; Timothy G Dinan

    2006-01-01

    The pathogenesis of Functional Dyspepsia (FD) remains unclear, appears diverse and is thus inadequately understood. Akin to other functional gastrointestinal disorders, research has demonstrated an association between this common diagnosis and psychosocial factors and psychiatric morbidity. Conceptualising the relevance of these factors within the syndrome of FD requires application of the biopsychosocial model of disease.Using this paradigm, dysregulation of the reciprocal communication between the brain and the gut is central to symptom generation, interpretation and exacerbation.Appreciation and understanding of the neurobiological correlates of various psychological states is also relevant.The view that psychosocial factors exert their influence in FD predominantly through motivation of health care seeking also persists. This appears too one-dimensional an assertion in light of the evidence available supporting a more intrinsic aetiological link. Evolving understanding of pathogenic mechanisms and the heterogeneous nature of the syndrome will facilitate effective management.Co-morbid psychiatric illness warrants treatment with conventional therapies. Acknowledging the relevance of psychosocial variables in FD, the degree of which is subject to variation, has implications for assessment and management. Available evidence suggests psychological therapies may benefit FD patients particularly those with chronic symptoms. The rationale for use of psychotropic medications in FD is apparent but the evidence base to support the use of antidepressant pharmacotherapy is to date limited.

  17. Environmental radiation studies relevant to thermoluminescence dating

    International Nuclear Information System (INIS)

    Murray, A.S.; Bowman, S.G.E.; Aitken, M.J.

    1980-01-01

    To determine the age of a potsherd by the thermoluminescence (TL) technique, one must have an accurate knowledge of the cosmic and environmental gamma dose rate in quartz. This is obtained by leaving a sensitive TL dosimeter buried as near as possible to the position from which the sherd was removed. The ratios of the response of a quartz-like dosimeter to those of CaF 2 and LiF have been measured. This experiment used a 1-m cube of concrete containing 3000 ppM of uranium and its daughters. Smaller, less active matrixes of 40 K and thorium and its daughters have also been constructed. A means of making direct dose-rate determinations when the site context remains but burial of a dosimeter is impractical was developed using a NaI(Tl) system. The equipment was field tested on approx. 40 Peruvian archaeological sites, and results are compared with CaF 2 measurements

  18. Temas ambientais relevantes Relevant environmental issues

    Directory of Open Access Journals (Sweden)

    Eneas Salati

    2006-04-01

    Full Text Available NESTE trabalho, são indicados os principais temas ambientais para o Brasil, num futuro próximo (2022. Impactos do aumento da temperatura são estudados através de cenários, que podem modificar o balanço hídrico em algumas regiões, tendo sido observado um aumento da ordem de 0,78ºC no período de 1917 a 2003, na região de Piracicaba. Para a região amazônica, foi observado um aumento de 0,56ºC durante o século XX. Tanto o desmatamento quanto as Mudanças Climáticas Globais atuam na direção de um aumento da temperatura, enquanto o desmatamento influi na direção de uma diminuição das precipitações. O desmatamento provoca, ainda, uma grande perda de biodiversidade, sendo estimadas em uma perda entre 8.000 até 34.000 espécies, considerando-se que o desmatamento aumenta em 1% ao ano.THIS PAPER indicates the environmental issues that must necessarily be approached, in Brazil, in a near future (2022. A study was made on some aspects of the effects of deforestation and Global Climate Change. A temperature rise around 0,78% has been observed during period of 1917 and 2003 in the Piracicaba region. For the Amazon region a rise of 0,56% was observed the 20th Century. The existing information indicates that not only deforestation but also Global Climate Changes act upon temperature rise. Deforestation has direct influence in precipitation decrease. The consequences of Global Climate Change are still unknown, being that some models indicate a precipitation rise and others a decrease. Deforestation also provokes great biodiversity loss, estimated between 8.000 to 34.000 species, considering that deforestation raises 1% per year.

  19. Relevance of Green Marketing on Environmental Degradation: An ...

    African Journals Online (AJOL)

    Relevance of Green Marketing on Environmental Degradation: An Empirical ... to others through product, process, packaging and advertising modification(s). ... thus appropriate strategies for effective application of green marketing are lacking.

  20. Environmental factors and leukaemia

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, L

    1985-01-01

    Investigations on the association between environmental hazards and the development of various types of leukaemia are reviewed. Regarding acute non-lymphocytic leukaemia (ANLL) exposure to ionizing radiation is a well-documented risk factor. According to several recent studies exposure to strong electromagnetic fields may be suspected to be of etiologic importance for ANLL. There is evidence that occupational handling of benzene is a risk factor and other organic solvents may also be leukaemogenic. Occupational exposure to petrol products has been proposed to be a risk factor although the hazardous substances have not yet been defined. Results of cytogenetic studies in ANLL suggest that exposure to certain environmental agents may be associated with relatively specific clonal chromosome aberrations. Exposure in utero to ionizing radiation has been proposed to be a risk factor for acute lymphocytic leukaemia (ALL) in children. Unlike ANLL there seems at present to be little evidence that ALL is related to exposure to some chemicals. Chronic myeloid leukaemia (CML) may follow exposure to high doses of ionizing radiation whereas such exposure seems to be of insignificant importance for the development of chronic lymphocytic leukaemia (CLL). According to some studies an abnormally high incidence of CLL may be found among farmers in the USA. These results have not been confirmed in Scandinavian studies. There seems to be little evidence that CML or CLL are related to occupational handling of some chemicals. 35 references.

  1. Effects of ethinylestradiol and of an environmentally relevant mixture of xenoestrogens on steroidogenic gene expression and specific transcription factors in zebrafish

    International Nuclear Information System (INIS)

    Urbatzka, R.; Rocha, E.; Reis, B.; Cruzeiro, C.; Monteiro, R.A.F.; Rocha, M.J.

    2012-01-01

    In natural environments fish are exposed to endocrine disrupting compounds (EDCs) present at low concentrations and with different modes of actions. Here, adult zebrafish of both sexes were exposed for 21 days to an estrogenic mixture (Mix) of eleven EDCs previously quantified in Douro River estuary (Portugal) and to 100 ng/L 17α-ethinylestradiol (EE2) as positive control. Vitellogenin mRNA and HSI in males confirmed both exposure regimes as physiologically active. Potential candidates for estrogenic disturbance of steroidogenesis were identified (StAR, 17β-HSD1, cyp19a1), but Mix only affected cyp19a1 in females. Significant differences in the response of FSHβ, cypa19a2, 20β-HSD were observed between EE2 and Mix. Mtf-1 and tfap2c transcription factor binding sites were discovered in the putative promoter regions and corresponding transcription factors were found to be differentially expressed in response to Mix and EE2. The results suggest that “non-classical effects” of estrogenic EDC in fish are mediated via transcription factors. - Highlights: ► Zebrafish were exposed to an estrogenic mixture (Mix) and to EE2 as positive control. ► Both exposure regimes were confirmed as physiologically active. ► Different disturbances on steroidogenesis were observed in males and females. ► A male gene expression pattern suggested a differential interference of Mix and EE2. ► Non-classical effects of Mix seem to be mediated via transcription factors. - An estrogenic mixture revealed different effects on specific transcription factors than EE2, probably due to multiple modes of actions of the chosen compounds.

  2. Analysis of Blood Concentrations of Zinc, Germanium, and Lead and Relevant Environmental Factors in a Population Sample from Shandong Province, China

    Directory of Open Access Journals (Sweden)

    Long Li

    2017-02-01

    Full Text Available Trace elements, including zinc (Zn and germanium (Ge, are essential for health; deficiency or excess levels of trace elements results is harmful. As a result of industrial and agricultural production, Pb widely exists in people’s living environment. It is absorbed mainly through the respiratory and digestive tracts, producing systemic harm. Reference values for a normal, healthy population are necessary for health assessment, prevention and treatment of related diseases, and evaluation of occupational exposures. Reference ranges for the Chinese population have not been established. From March 2009 to February 2010; we collected data and blood samples (n = 1302 from residents aged 6–60 years living in Shandong Province, China. We measured blood concentrations of Zn, Ge, and Pb using inductively coupled plasma mass spectrometry to determine reference ranges. Results were stratified by factors likely to affect the concentrations of these trace elements: sex, use of cosmetics or hair dye, age, alcohol intake, smoking habits, and consumption of fried food. The overall geometric mean (GM concentrations (95% confidence interval were 3.14 (3.08–3.20 mg/L for Zn, 19.9 (19.3–20.6 μg/L for Ge, and 24.1 (23.2–25.1 μg/L for Pb. Blood Zn concentrations were higher in women than in men (p < 0.001, while the opposite was found for Pb (p < 0.001 and sex did not influence Ge (p = 0.095. Alcohol use was associated with higher blood concentrations of Zn (p = 0.002, Ge (p = 0.002, and Pb (p = 0.001. The GM concentration of Zn was highest in 20–30-year-olds (p < 0.001, while Pb concentrations were highest in 12–16-year-olds (p < 0.001. Use of hair dye was associated with lower blood concentrations of Ge (p < 0.05. GM blood concentrations of Pb differed significantly between those who consumed fried foods 1–2 times/month (18.7 μg/L, 1–2 times/week (20.9 μg/L, and every day (28.5 μg/L; p < 0.001. Blood Pb concentrations were higher in subjects

  3. The policy relevance of global environmental change research

    International Nuclear Information System (INIS)

    Yarnal, Brent

    1996-01-01

    Many scientists are striving to identify and promote the policy implications of their global change research. Much basic research on global environmental change cannot advance policy directly, but new projects can determine the relevance of their research to decision makers and build policy-relevant products into the work. Similarly, many ongoing projects can alter or add to the present science design to make the research policy relevant. Thus, this paper shows scientists working on global change how to make their research policy relevant. It demonstrates how research on physical global change relates to human dimensions studies and integrated assessments. It also presents an example of how policy relevance can be fit retroactively into a global change project (in this case, SRBEX-the Susquehanna River Basin Experiment) and how that addition can enhance the project's status and science. The paper concludes that policy relevance is desirable from social and scientific perspectives

  4. Environmentally relevant approaches to assess nanoparticles ecotoxicity: A review

    Energy Technology Data Exchange (ETDEWEB)

    Bour, Agathe; Mouchet, Florence; Silvestre, Jérôme; Gauthier, Laury [Université de Toulouse (France); UPS, INP (France); EcoLab (Laboratoire d’écologie fonctionnelle et environnement) (France); ENSAT, Avenue de l’Agrobiopôle, F-31326 Castanet-Tolosan (France); CNRS (France); EcoLab (Laboratoire d’écologie fonctionnelle et environnement), F-31326 Castanet-Tolosan (France); Pinelli, Eric, E-mail: pinelli@ensat.fr [Université de Toulouse (France); UPS, INP (France); EcoLab (Laboratoire d’écologie fonctionnelle et environnement) (France); ENSAT, Avenue de l’Agrobiopôle, F-31326 Castanet-Tolosan (France); CNRS (France); EcoLab (Laboratoire d’écologie fonctionnelle et environnement), F-31326 Castanet-Tolosan (France)

    2015-02-11

    Highlights: • Integrated ecotoxicity of NPs from organism to community level is reviewed. • Trophic chains allow determining the implication of trophic route in NP toxicity. • The use of microcosms and mesocosms allows studies at larger scale. • Data concerning NP fate and effects in environmental conditions are lacking. - Abstract: Despite the increasing production and use of nanoparticles (NPs), there is a lack of knowledge about their environmental fate and ecotoxicity. Studies in environmentally relevant conditions are necessary to better assess these parameters, but such studies are rather rare. The present work represents first time that studies on engineered NPs using environmentally relevant exposure methods have been reviewed. These exposure methods differ from standardized protocols and can be classified into three groups: experimental trophic chains that allow study of the trophic route, multi-species exposures under laboratory conditions that allow for complex but controlled exposure and outdoor exposures that are more similar to environmentally realistic conditions. The majority of studies of micro- or mesocosms have focused on NP partitioning and bioaccumulation. The other major parameter that has been studied is NP ecotoxicity, which has been assessed in single species, in single species via the trophic route, and at the community level. The induction of biochemical defense systems, immunomodulation, effects on growth and reproduction, behavioral alterations and mortality have been used as indicators of major toxicity, depending on the species studied. The major effects of NPs on both microbial and algal communities include modifications of community compositions and diversities, decreased biomass and changes in community activities.

  5. Environmentally relevant approaches to assess nanoparticles ecotoxicity: A review

    International Nuclear Information System (INIS)

    Bour, Agathe; Mouchet, Florence; Silvestre, Jérôme; Gauthier, Laury; Pinelli, Eric

    2015-01-01

    Highlights: • Integrated ecotoxicity of NPs from organism to community level is reviewed. • Trophic chains allow determining the implication of trophic route in NP toxicity. • The use of microcosms and mesocosms allows studies at larger scale. • Data concerning NP fate and effects in environmental conditions are lacking. - Abstract: Despite the increasing production and use of nanoparticles (NPs), there is a lack of knowledge about their environmental fate and ecotoxicity. Studies in environmentally relevant conditions are necessary to better assess these parameters, but such studies are rather rare. The present work represents first time that studies on engineered NPs using environmentally relevant exposure methods have been reviewed. These exposure methods differ from standardized protocols and can be classified into three groups: experimental trophic chains that allow study of the trophic route, multi-species exposures under laboratory conditions that allow for complex but controlled exposure and outdoor exposures that are more similar to environmentally realistic conditions. The majority of studies of micro- or mesocosms have focused on NP partitioning and bioaccumulation. The other major parameter that has been studied is NP ecotoxicity, which has been assessed in single species, in single species via the trophic route, and at the community level. The induction of biochemical defense systems, immunomodulation, effects on growth and reproduction, behavioral alterations and mortality have been used as indicators of major toxicity, depending on the species studied. The major effects of NPs on both microbial and algal communities include modifications of community compositions and diversities, decreased biomass and changes in community activities

  6. Environmental Factors and Cardiovascular Diseases

    Directory of Open Access Journals (Sweden)

    Omer Faruk Tekbas

    2008-10-01

    Full Text Available Epidemiological and clinical observations have led to the hypothesis that the risk of developing cardiovascular diseases is influenced not only by genetic, lifestyle and major risk factors, but also by environmental factors. Environmental factors are considered key determinants of cardiovascular diseases. Although lifestyle choices such as smoking, diet, and exercise are viewed as major environmental influences, the contribution of pollutants and environmental chemicals is less clear. Accumulating evidence suggests that exposure to physically and chemical pollutants could elevate the risk of cardiovascular diseases. Many epidemiological studies report that exposure to physically, biologically and socio-cultural environmental factors are associated with an increase in cardiovascular mortality. Relationships between environmental factors and coronary arter disease, arhythmias, and cardiomyopathies have been reported. Exposures to arsenic, lead, cadmium, pollutant gases, solvents, and pesticides have also been linked to increased incidence of cardiovascular disease. In this paper, I review that relationships between exposure to physically, chemical, biologically and socio-cultural environmental factors and cardiovascular diseases. [TAF Prev Med Bull 2008; 7(5.000: 435-444

  7. HIV: Social and Environmental Factors

    Centers for Disease Control (CDC) Podcasts

    Dr. Kevin Fenton, Director of CDC’s National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, discusses how social and environmental factors may put African Americans at greater risk for HIV.

  8. Towards policy relevant environmental modeling: contextual validity and pragmatic models

    Science.gov (United States)

    Miles, Scott B.

    2000-01-01

    "What makes for a good model?" In various forms, this question is a question that, undoubtedly, many people, businesses, and institutions ponder with regards to their particular domain of modeling. One particular domain that is wrestling with this question is the multidisciplinary field of environmental modeling. Examples of environmental models range from models of contaminated ground water flow to the economic impact of natural disasters, such as earthquakes. One of the distinguishing claims of the field is the relevancy of environmental modeling to policy and environment-related decision-making in general. A pervasive view by both scientists and decision-makers is that a "good" model is one that is an accurate predictor. Thus, determining whether a model is "accurate" or "correct" is done by comparing model output to empirical observations. The expected outcome of this process, usually referred to as "validation" or "ground truthing," is a stamp on the model in question of "valid" or "not valid" that serves to indicate whether or not the model will be reliable before it is put into service in a decision-making context. In this paper, I begin by elaborating on the prevailing view of model validation and why this view must change. Drawing from concepts coming out of the studies of science and technology, I go on to propose a contextual view of validity that can overcome the problems associated with "ground truthing" models as an indicator of model goodness. The problem of how we talk about and determine model validity has much to do about how we perceive the utility of environmental models. In the remainder of the paper, I argue that we should adopt ideas of pragmatism in judging what makes for a good model and, in turn, developing good models. From such a perspective of model goodness, good environmental models should facilitate communication, convey—not bury or "eliminate"—uncertainties, and, thus, afford the active building of consensus decisions, instead

  9. The Relevant Factors in Promoting Reading Activities in Elementary Schools

    Science.gov (United States)

    Huang, Han-Chen; Tsai, Yao-Hsu; Huang, Shih-Hsiang

    2015-01-01

    In order to help students absorb knowledge, schools often conduct reading activities. Thorough planning and strategies, however, are needed to insure the effect of reading promotions, and make them a deeply-rooted part of life. This study adopted the analytic hierarchy process (AHP) to discuss the relevant factors in promoting reading activities…

  10. HIV: Social and Environmental Factors

    Centers for Disease Control (CDC) Podcasts

    2012-02-01

    Dr. Kevin Fenton, Director of CDC’s National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, discusses how social and environmental factors may put African Americans at greater risk for HIV.  Created: 2/1/2012 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 2/1/2012.

  11. Dissociative absorption: An empirically unique, clinically relevant, dissociative factor.

    Science.gov (United States)

    Soffer-Dudek, Nirit; Lassri, Dana; Soffer-Dudek, Nir; Shahar, Golan

    2015-11-01

    Research of dissociative absorption has raised two questions: (a) Is absorption a unique dissociative factor within a three-factor structure, or a part of one general dissociative factor? Even when three factors are found, the specificity of the absorption factor is questionable. (b) Is absorption implicated in psychopathology? Although commonly viewed as "non-clinical" dissociation, absorption was recently hypothesized to be specifically associated with obsessive-compulsive symptoms. To address these questions, we conducted exploratory and confirmatory factor analyses on 679 undergraduates. Analyses supported the three-factor model, and a "purified" absorption scale was extracted from the original inclusive absorption factor. The purified scale predicted several psychopathology scales. As hypothesized, absorption was a stronger predictor of obsessive-compulsive symptoms than of general psychopathology. In addition, absorption was the only dissociative scale that longitudinally predicted obsessive-compulsive symptoms. We conclude that absorption is a unique and clinically relevant dissociative tendency that is particularly meaningful to obsessive-compulsive symptoms. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. Social relevance of environmental toxicology. Die gesellschaftspolitische Relevanz der Umwelttoxikologie

    Energy Technology Data Exchange (ETDEWEB)

    Alsen, C; Wassermann, O

    1986-01-01

    Environmental toxicology investigates harmful substances in the media air, water, soil and food. This field of research ascertains the effects on humans and on the living world not only to elucidate the causality of already apparent damage, but also to provide the rational basis for therapeutic attempts and, particularly, for prevention. The alarming scale of anthropogenic environmental pollution inevitably implies conflicts for committed environmental toxicologists with individuals or groups of the society interested to conceal and appease the facts. Considerable obstacles to successful toxicological research of environmental pollution come from the entanglement of interests between industry, politics and bureaucracy. Public pressure from well-informed and worried citizens initiatives, however, also convinced other scientific disciplines that in many instances environmental pollution has passed already justifiable limits. Each member of the society, especially those in industry and politics, must become aware of the fact, that conventional economy, which disregards ecological interrelations, cannot be financed in the future. (orig./HSCH).

  13. Relevance of environmental concerns in contemplating development of fission fusion hybrids: a personal view

    International Nuclear Information System (INIS)

    Holdren, J.

    1974-01-01

    A brief comparison of hybrids to pure fusion systems with respect to timing and economics is given. The relevance of environmental concerns is discussed along with environmental criteria for hybrid designs. (U.S.)

  14. [Relevance of Personality Factors for Successful Vocational Rehabilitation].

    Science.gov (United States)

    Arling, V; Slavchova, V; Knispel, J; Spijkers, W

    2016-02-01

    The Main purpose of vocational rehabilitation is occupational reintegration of clients into the job market who have lost their job or whose job is threatened because of a handicap or chronicl illness. With regard to existing evidence for the relevance of personality factors for work performance and job achievement, the present study investigated the influence of participants' personality factors on a successful reintegration after a retraining program in a vocational training center over 2 years. A central research objective was to identify prognostic personality factors for successful vocational integration. In this longitudinal study 15 vocational training centers participated at 3 time points of measurement (T1, T2 and T3). Data gathering was based on rehabilitants' self-reports (standardized questionnaires: SVF, BSW, SPR, CSES) about personality aspects. First data collection started at the beginning (T1) and a second survey was conducted at the end of the training 2 years later (T2). Based on the data at measurement points T1 and T2, 4 prognostic models were computed (binary logistic regression analysis) and evaluated, examining the differenzial influence of several scales and items on direct reintegration after completing the vocational retraining and reintegration status 6 months later (T3). As expected, different variables turned out to be relevant for occupational integration at the end of the training program and 6 months later. Correspondingly other variables appeared to be relevant for occupational reintegration at T1 and at T2. At the end of the vocational training program, approximately 24% of the participants had a job. With respect to direct reintegration, regression analysis revealed that vocational self-efficacy (R(2)=0,175) and self-evaluation were relevant (R(2)=0,383). Approximately 70% of the participants had gotten a job 6 months later. Several stress coping strategies (R(2)=0,170), estimation of the own reintegration prognosis and aspects

  15. Monitoring fate and behaviour of Nanoceria under relevant environmental conditions

    CSIR Research Space (South Africa)

    Tancu, Y

    2014-11-01

    Full Text Available ). The results revealed significant tendency of nCeO¬2 to undergo aggregation, agglomeration and certain degree of deagglomeration processes under different environmental conditions. Moreover, the findings suggested that both electrostatic and steric interactions...

  16. Environmental factors and semen quality

    DEFF Research Database (Denmark)

    Jurewicz, Joanna; Hanke, Wojciech; Radwan, Michal

    2009-01-01

    , trihalomethanes (THMs), mobile phones) on semen quality, by reviewing most recent published literature. MATERIALS AND METHODS: Epidemiological studies focusing on exposure to environmental factors and semen quality for the last ten years were identified by a search of the Pubmed, Medline, Ebsco, Agricola...... to sperm motility. In case of air pollution, studies suggest a link between ambient air pollutants and various semen characteristics. Additional research is needed to corroborate this association and to establish the causal agents. Results of few studies on subfertile men demonstrate associations between...... phthalate levels commonly experienced by the public and impaired sperm quality (impact on sperm concentration, morphology, motility), but the findings have not been corroborated in studies of men from the general population. Mobile phones might adversely affect the quality of semen by decreasing mostly...

  17. The scope of environmental impact statements for biofuelled energy plants in Sweden and its environmental relevance

    Energy Technology Data Exchange (ETDEWEB)

    Bruhn-Tysk, S.

    2001-03-01

    This thesis aims to evaluate how the Swedish environmental impact assessment (EIA) system works in practice and to analyse the environmental relevance of the scoping process during the ElA process. As a case study, environmental impact statements (EISs) for bio fuelled energy plants have been reviewed in order to illustrate the scope of the statements and hence evaluate how the ElA system works and analyses what environmental aspects that are prioritised by ElA actors. Based on the review results, the scope of the EISs indicates that the Swedish ElA system did not work as intended during the studied period since not even the legal requirements were fulfilled in many of the EISs. In addition, international EIA practice does not seem to have influenced the Swedish practice of ElA at that time. The EISs also show that EIA actors apply narrow system boundaries, i.e. they focus only on the activities of the energy plant that are explicitly linked to the energy plant location and its immediate vicinity. Moreover, these narrow system boundaries exclude important aspects of an energy plant, like resource extraction and global and long-term effects. Many of the energy plants have been planned and developed partly due to a Government Bill, in which a development of the Swedish energy system was proposed in order to achieve a sustainable development of Sweden. However, a sustainable development requires that effects on present as well as future generations are focused on as well. Therefore, an ElA process and a decision-making process, which prioritises local and short-term effects, often do not promote the societal goals of sustainable development. In order to promote the goals of sustainable development, the perspectives of ElA actors have to widen to include global and future, long-term effects.

  18. Relevant dimensions for proactive environmental assessment of urban mobility

    Directory of Open Access Journals (Sweden)

    Julio Alberto Soria Lara

    2015-02-01

    Full Text Available A reduction of negative environmental impacts in urban transportation (air pollution, energy consumption, etc. is thought to be crucial in promoting sustainable development outcomes in cities, however evidence shows that this objective is hardly achieved in practice. In the case of urban transport planning, the transition to sustainability requests that its performance must be assessed. This has originated important challenges for the academia in providing efficient assessment tools. As a response to these challenges, sustainability assessment has become a rapidly developing area associated with the family of impact assessment tools ((e.g. Environmental Impact Assessment and Strategic Environmental Assessment. In recent years, many countries have conferred to sustainability assessment, and specifically to Environmental Impact Assessment (EIA, an important and decisive role into their planning systems. The effectiveness of the traditional methods for evaluating urban transport plans/interventions (e.g. EIA, EAE, Cost-Benefit Analysis is contested as strongly argued by several academics. A key problem is that these methods currently focus too much on identifying environmental impacts that might happen rather than on finding ways of preventing them from happening. They are used reactively rather than proactively. Underlying this is the belief that traditional evaluation methods have difficulty guiding improvements in urban transport plans and projects in decision-making and their capacity to support technical decisions becomes limited. First, this is a consequence of the fact that the environmental assessment (EA process mainly includes EA-makers and they are not integrated enough in the transport planning process. Second, the used methods not always are the most suitable to identify ways of preventing potential impacts with respect to the particular nature of urban transportation. In seeking to answer these problems, the paper presents a strategy

  19. Cadmium toxicity investigated at the physiological and biophysical levels under environmentally relevant conditions using the aquatic model plant Ceratophyllum demersum

    Czech Academy of Sciences Publication Activity Database

    Andresen, Elisa; Kappel, S.; Stärk, H.-J.; Riegger, U.; Borovec, Jakub; Mattusch, J.; Heinz, A.; Schmelzer, C.E.H.; Matoušková, Šárka; Dickinson, B.; Küpper, Hendrik

    2016-01-01

    Roč. 210, č. 4 (2016), s. 1244-1258 ISSN 0028-646X Institutional support: RVO:60077344 ; RVO:67985831 Keywords : Ceratophyllum demersum * Environmentally relevant * Light-harvesting complexes (LHCs) * Toxic metals Subject RIV: CE - Biochemistry; DD - Geochemistry (GLU-S) Impact factor: 7.330, year: 2016

  20. Analysis of the Relevant Factors of Retaining Women in Judo

    Directory of Open Access Journals (Sweden)

    Joško Sindik

    2014-09-01

    Full Text Available This study aimed to determine the latent dimensions of all relevant factors about engagement of women in judo, to determine the intercorrelations among these latent dimensions, as well as the correlations with three relevant variables. Final goal was to determine the differences in revealed latent dimensions, in relation to several independent variables: educational level, marital status, impulses to engage in judo, then depending are the women athletes (competitors or not, members of the Board or not, trainers or not. A total of 50 female judokas from a larger number of Croatian clubs were examined, by specially composed the survey. The results showed that all seven questionnaires showed medium to high satisfactory reliability, together with good con¬struct validity, in 15 latent dimensions that are revealed. It can be noticed that relatively older women have more obligations and more barriers that oppose to their engagement in judo. Only small number of differences are found among women engaged in judo, mainly among participants who are members of the Board in the club or Croatian Judo Federation, as compared with those who are not. Small number of statistically significant differences (as well as the correlations can be also observed as the fact that all women partially share similar problems, while the media strategies are perceived as the most powerful to increase women’s persistence in judo, in any type of engagement.

  1. Discussion in primary ecological environmental problems and relevant countermeasures in China

    International Nuclear Information System (INIS)

    An Yongfeng

    2003-01-01

    On the basis of sufficient statistical data, the primary ecological environmental problems, including water/soil loss and dissertation, water resource shortage and water pollution, deterioration of air quality and air pollution, despoilation of biodiversity, and environmental pollution, are listed in this paper. In addition, the causes of these problems are analyzed. Finally, relevant strategies and measures for environmental protection are brought forward. (authors)

  2. Relevance of Environmental, Institutional and Economic Developments for ASEAN-6

    OpenAIRE

    Ikhlaq, Muhammad Waleed

    2016-01-01

    Economic Growth is influenced by large number of factors and there is an ongoing debate on the extent to which some of these strong and more quantifiable variables are effective. In order to comprehensively discuss the mainstream determinants of Economic Growth explored through past literature, the study chose to focus on ASEAN-6 countries encompassing Singapore, Malaysia, Indonesia, Thailand, Philippines and Vietnam. By considering three decades from 1985 to 2014 period and dividing it into ...

  3. Environmental radiological monitoring methods in TENORM facilities and its relevance

    International Nuclear Information System (INIS)

    Teng Iyu Lin; Ismail Bahari; Muhamad Samudi Yasir

    2011-01-01

    In Malaysia, mineral processing plant is one of the Naturally Occurring Radioactive Material (NORM) processing industries controlled by the Atomic Energy Licensing Board (AELB) through the enforcement of Atomic Energy Licensing Act 1984 (Act 304). The activities generated waste which is called as TENORM wastes. TENORM wastes are mainly found in thorium hydroxide from the processing of xenotime and monazite, and iron oxide and red gypsum from the processing of ilmenite. Other TENORM wastes are scales and sludge from the oil and gas industries, tin slag produced from the smelting of tin, and ilmenite, zircon, and monazite produced from the processing of tin tailing (amang). The environmental and radiological monitoring program is needed to ensure that the TENORM wastes did not caused any contamination to the environment. The wastes vary in the types of samples, parameters of analysis as well as the frequency of monitoring based on licenses conditions issued by the AELB. The main objective of this study is to assess the suitability of licenses condition and the monitoring program required in oil and gas, and mineral processing industries. Study was done by assessing the data submitted to the AELB in order to comply with the licensing requirement. This study had found out that there are a few of licenses conditions that need to be reviewed accordingly based on the processing activity. (Author)

  4. Inhibition of calcium phosphate precipitation under environmentally-relevant conditions

    International Nuclear Information System (INIS)

    Cao Xinde; Harris, Willie G.; Josan, Manohardeep S.; Nair, Vimala D.

    2007-01-01

    Precipitation of Ca phosphates plays an important role in controlling P activity and availability in environmental systems. The purpose of this study was to determine inhibitory effects on Ca phosphate precipitation by Mg 2+ , SO 4 2- , CO 3 2- , humic acid, oxalic acid, biogenic Si, and Si-rich soil clay commonly found in soils, sediments, and waste streams. Precipitation rates were determined by measuring decrease of P concentration in solutions during the first 60 min; and precipitated solid phases identified using X-ray diffraction and electron microscopy. Poorly-crystalline hydroxyapatite (HAP: Ca 5 (PO 4 ) 3 OH) formed in control solutions over the experiment period of 24 h, following a second-order dependence on P concentration. Humic acid and Mg 2+ significantly inhibited formation of HAP, allowing formation of a more soluble amorphous Ca phosphate phase (ACP), and thus reducing the precipitation rate constants by 94-96%. Inhibition caused by Mg 2+ results from its incorporation into Ca phosphate precipitates, preventing formation of a well-crystalline phase. Humic acid likely suppressed Ca phosphate precipitation by adsorbing onto the newly-formed nuclei. Presence of oxalic acid resulted in almost complete inhibition of HAP precipitation due to preemptive Ca-oxalate formation. Carbonate substituted for phosphate, decreasing the crystallinity of HAP and thus reducing precipitation rate constant by 44%. Sulfate and Si-rich solids had less impact on formation of HAP; while they reduced precipitation in the early stage, they did not differ from the control after 24 h. Results indicate that components (e.g., Mg 2+ , humic acid) producing relatively soluble ACP are more likely to reduce P stability and precipitation rate of Ca phosphate in soils and sediments than are components (e.g., SO 4 2- , Si) that have less effect on the crystallinity

  5. Environmental restoration issues relevant to lands that support native populations

    International Nuclear Information System (INIS)

    Simon, S.L.

    1999-01-01

    Islands and other remote locations that support indigenous (native) populations require special considerations in the setting of criteria for maximum allowable radioactivity contamination of the environment. The criteria can differ from those applicable to Western continental urban settings because of particular attributes related to lifestyle or environment. Conventionally, guidelines for land cleanup are derived by using a pathway model and descriptions of conventional intake patterns to calculate backwards from an acceptable dose or risk. However, pathways of possible exposure differ in characteristics and relative importance for indigenous populations, and conventional exposure-assessment models need considerable revision for them. More primitive lifestyles usually imply a need for stricter standards. In contrast, somewhat higher risk might not produce any excess cancer incidence if the population is small enough, as is often the case for islanders or other indigenous populations. This paper discusses various factors peculiar to indigenous populations that require consideration when criteria for restoration of contaminated environments are being determined. (author)

  6. Factors relevant to the sealing of nuclear facilities

    International Nuclear Information System (INIS)

    1991-05-01

    This report reviews and summaries the factors to be considered in the design, construction and surveillance of confinement structures for damaged nuclear facilities. General engineering, design and environmental considerations are included, both from the standpoint of the mitigation of near-term effects by virtue of interim confinement, and from the standpoint of the acceptability of the structure for long-term confinement. Factors which influence optimization of the design and the construction sequence are reviewed, including the nature of the accident, natural conditions of the site, and thermal and radiation effects. Safety criteria are presented from the standpoint of regulatory requirements, radiological consequences, and monitoring/surveillance requirements for both interim and long-term confinement. Methodologies related to concrete fabrication technology and other construction techniques appropriate for building confinement structures are discussed. Long-term considerations relative to the future of the site for in-place storage/disposal of the waste, and possible future reuse of the site are also included

  7. Transport of Fluorescently Labeled Hydroxyapatite Nanoparticles in Saturated Granular Media at Environmentally Relevant Concentrations of Surfactants

    Science.gov (United States)

    Little is known about the mobility of engineered nanoparticles (ENPs) in granular media at environmentally relevant concentration of surfactant, which represents a critical knowledge gap in employing ENPs for in-situ remediation of contaminated groundwater. In this study, transpo...

  8. Considerations of Environmentally Relevant Test Conditions for Improved Evaluation of Ecological Hazards of Engineered Nanomaterials

    Science.gov (United States)

    Engineered nanomaterials (ENMs) are increasingly entering the environment with uncertain consequences including potential ecological effects. Various research communities view differently whether ecotoxicological testing of ENMs should be conducted using environmentally relevant ...

  9. Environmental Factors Affecting Preschoolers' Motor Development

    Science.gov (United States)

    Venetsanou, Fotini; Kambas, Antonis

    2010-01-01

    The process of development occurs according to the pattern established by the genetic potential and also by the influence of environmental factors. The aim of the present study was to focus on the main environmental factors affecting motor development. The review of the literature revealed that family features, such as socioeconomic status,…

  10. Environmental risk factors and pressures

    International Nuclear Information System (INIS)

    Klinda, J.; Lieskovska, Z.

    1998-01-01

    In this chapter the physical risk factors (as radiation [air contamination, contamination of the environment components and food contamination], radon and its radioactive decay products, radioactive wastes, noise), chemical risk factors [chemical substances, xenobiotics in the food chain the ozone depletion], wastes (waste generation, waste management, municipal waste management, import, export and transit of waste) and natural an technological hazards (water quality deterioration as a result of various accidents and fire risk) in the Slovak Republic in 1997 are reviewed

  11. Vandalism: Environmental and Social Factors

    Science.gov (United States)

    Brown, Gregory; Devlin, Ann Sloan

    2003-01-01

    To explore the relationship between vandalism, college residence hall size, and a number of social factors, 688 college students completed the Core Alcohol and Drug Survey (Presley, Meilman, & Lyerla, 1994), the University Residence Environment Scale (Moos, 1988), and answered questions about their television habits and athletic participation.…

  12. Environmental Factors Influencing Epidemic Cholera

    Science.gov (United States)

    Jutla, Antarpreet; Whitcombe, Elizabeth; Hasan, Nur; Haley, Bradd; Akanda, Ali; Huq, Anwar; Alam, Munir; Sack, R. Bradley; Colwell, Rita

    2013-01-01

    Cholera outbreak following the earthquake of 2010 in Haiti has reaffirmed that the disease is a major public health threat. Vibrio cholerae is autochthonous to aquatic environment, hence, it cannot be eradicated but hydroclimatology-based prediction and prevention is an achievable goal. Using data from the 1800s, we describe uniqueness in seasonality and mechanism of occurrence of cholera in the epidemic regions of Asia and Latin America. Epidemic regions are located near regional rivers and are characterized by sporadic outbreaks, which are likely to be initiated during episodes of prevailing warm air temperature with low river flows, creating favorable environmental conditions for growth of cholera bacteria. Heavy rainfall, through inundation or breakdown of sanitary infrastructure, accelerates interaction between contaminated water and human activities, resulting in an epidemic. This causal mechanism is markedly different from endemic cholera where tidal intrusion of seawater carrying bacteria from estuary to inland regions, results in outbreaks. PMID:23897993

  13. Analysis of the Relevant Factors for the Engaging Women in Various Sports in Croatia

    Directory of Open Access Journals (Sweden)

    Joško Sindik

    2016-03-01

    Full Text Available Goals of this research were to determine the correlations among the dimensions of relevant factors about engagement of women in sports, as well as to determine the differences in the dimensions of relevant factors about engagement of women in sports, according to several independent variables: type of sport, educational level, marital status and place of living. A total of 342 female athletes and other sport practitioners are examined, with the average age of 31.53±13.92 years (M±SD from several Croatian sport federations: judo, badminton, gymnastics, bowling, acrobatic rock’n roll, handball, sport fishing, Association of the deaf athletes, archery, chess and basketball. The results revealed that according to the type of sport, the differences are statistically significant for: negative environment, relaxation/fun and ambition/self-esteem motives; environmental, obligation and financial/traffic/rules barriers; indirect strategies and already present initiatives for including women in sports. According to the education level, the differences are statistically significant for: positive personal, negative environmental motives and ambition/self-esteem motives; obligations as the barriers; organization out-of-sport commitments and specific strategies for media. The differences in the marital status of participants are statistically significant for the variables: positive personal, negative environmental and ambition/self-esteem motives; environmental and obligation barriers; organization of out-of-sport commitments. At last, only two statistically significant differences are found according to the place of living: for indirect strategies for including women in sports and for the programs created only for women. The results provide the platform for developing programs and strategies for retaining and engaging women in particular sports in Croatia.

  14. Environmental biodosimetry: a biologically relevant tool for ecological risk assessment and biomonitoring

    Energy Technology Data Exchange (ETDEWEB)

    Ulsh, B. E-mail: ulshb@mcmaster.ca; Hinton, T.G.; Congdon, J.D.; Dugan, L.C.; Whicker, F.W.; Bedford, J.S

    2003-07-01

    Biodosimetry, the estimation of received doses by determining the frequency of radiation-induced chromosome aberrations, is widely applied in humans acutely exposed as a result of accidents or for clinical purposes, but biodosimetric techniques have not been utilized in organisms chronically exposed to radionuclides in contaminated environments. The application of biodosimetry to environmental exposure scenarios could greatly improve the accuracy, and reduce the uncertainties, of ecological risk assessments and biomonitoring studies, because no assumptions are required regarding external exposure rates and the movement of organisms into and out of contaminated areas. Furthermore, unlike residue analyses of environmental media environmental biodosimetry provides a genetically relevant biomarker of cumulative lifetime exposure. Symmetrical chromosome translocations can impact reproductive success, and could therefore prove to be ecologically relevant as well. We describe our experience in studying aberrations in the yellow-bellied slider turtle as an example of environmental biodosimetry.

  15. Regulatory relevant and reliable methods and data for determining the environmental fate of manufactured nanomaterials

    DEFF Research Database (Denmark)

    Baun, Anders; Sayre, Phil; Steinhäuser, Klaus Günter

    2017-01-01

    The widespread use of manufactured nanomaterials (MN) increases the need for describing and predicting their environmental fate and behaviour. A number of recent reviews have addressed the scientific challenges in disclosing the governing processes for the environmental fate and behaviour of MNs,...... data. Gaps do however exist in test methods for environmental fate, such as methods to estimate heteroagglomeration and the tendency for MNs to transform in the environment.......The widespread use of manufactured nanomaterials (MN) increases the need for describing and predicting their environmental fate and behaviour. A number of recent reviews have addressed the scientific challenges in disclosing the governing processes for the environmental fate and behaviour of MNs......, however there has been less focus on the regulatory adequacy of the data available for MN. The aim of this paper is therefore to review data, testing protocols and guidance papers which describe the environmental fate and behaviour of MN with a focus on their regulatory reliability and relevance. Given...

  16. Elucidation of the Mechanisms and Environmental Relevance of cis-Dichloroethene and Vinyl Chloride Biodegradation

    Science.gov (United States)

    2012-11-01

    thus appears that Polaromonas sp. JS666 is a safe candidate for use in bioremediation , bioaugmentation or monitored natural attenuation. 3.1.6...of multiple chlorinated ethene sources in an industrialized area. A forensic field study using compound-specific isotope analysis." Environmental ...Degrading Bacterium, and Features of Relevance to Biotechnology .” Applied and Environmental Microbiology 74(20): 6405-6416. Maymó-Gatell, X., Y.-t

  17. More than a Museum: Natural History is Relevant in 21st Century Environmental Science

    Science.gov (United States)

    Hernandez, R. R.; Murphy-Mariscal, M. L.; Barrows, C. W.

    2015-12-01

    In the Anthropocene, the relevancy of natural history in environmental science is challenged and marginalized today more than ever. We tested the hypothesis that natural history is relevant to the fields of environmental science and ecology by assessing the values, needs, and decisions related to natural history of graduate students and environmental science professionals across 31 universities and various employers, respectively, in California. Graduate students surveyed (93.3%) agreed that natural history was relevant to science, approximately 70% believed it "essential" for conducting field-based research; however, 54.2% felt inadequately trained to teach a natural history course and would benefit from additional training in natural history (> 80%). Of the 185 professionals surveyed, all felt that natural history was relevant to science and "essential" or "desirable" in their vocation (93%). Our results indicate a disconnect between the value and relevancy of natural history in 21st century ecological science and opportunities for gaining those skills and knowledge through education and training.

  18. Organismal climatology: analyzing environmental variability at scales relevant to physiological stress.

    Science.gov (United States)

    Helmuth, Brian; Broitman, Bernardo R; Yamane, Lauren; Gilman, Sarah E; Mach, Katharine; Mislan, K A S; Denny, Mark W

    2010-03-15

    Predicting when, where and with what magnitude climate change is likely to affect the fitness, abundance and distribution of organisms and the functioning of ecosystems has emerged as a high priority for scientists and resource managers. However, even in cases where we have detailed knowledge of current species' range boundaries, we often do not understand what, if any, aspects of weather and climate act to set these limits. This shortcoming significantly curtails our capacity to predict potential future range shifts in response to climate change, especially since the factors that set range boundaries under those novel conditions may be different from those that set limits today. We quantitatively examine a nine-year time series of temperature records relevant to the body temperatures of intertidal mussels as measured using biomimetic sensors. Specifically, we explore how a 'climatology' of body temperatures, as opposed to long-term records of habitat-level parameters such as air and water temperatures, can be used to extrapolate meaningful spatial and temporal patterns of physiological stress. Using different metrics that correspond to various aspects of physiological stress (seasonal means, cumulative temperature and the return time of extremes) we show that these potential environmental stressors do not always occur in synchrony with one another. Our analysis also shows that patterns of animal temperature are not well correlated with simple, commonly used metrics such as air temperature. Detailed physiological studies can provide guidance to predicting the effects of global climate change on natural ecosystems but only if we concomitantly record, archive and model environmental signals at appropriate scales.

  19. [Relevant factors in medico-legal prognosis of whiplash injury].

    Science.gov (United States)

    Pujol, Amadeo; Puig, Luisa; Mansilla, Joaquina; Idiaquez, Itziar

    2003-07-12

    Whiplash injury (WI) is commonly evaluated in medico-legal practice. With the aim of knowing the determining factors of WI's medico-legal prognosis, a prospective and observational study was carried out. One hundred and twenty consecutive patients who were clinically observed and evaluated in the Medico-Legal Clinic of Barcelona were studied. Socio-demographic, clinical, radiographic and evolutive factors were analyzed. We included 120 patients with a mean age of 35.6 (14) years (range, 4-74), with a homogeneous male/female distribution. An earlier cervical pathology was detected in 10% of patients; none of them had previous psychiatric pathology. 95% corresponded to road-traffic accident cases and there were 5 aggression cases. Over 50% of cases involved a rear-end collision. All patients had neck pain, almost 25% had headache and 13% had paresthesia. According to the Whiplash Association Disorders clinical classification, distribution in grades (G) was: G I 51%, G II 32% and G III 17%. Patients reported recovery within a mean time of 71.6 (46) days (range, 4-244), with 51,2 (45) no working days (range, 0-180 days). The 52% of the patients rest with complains. According to the recovery time, the following medico-legal prognostic factors were identified: age (p legal prognostic factors were age, being females, severity of initial clinical symptoms, previous cervical pathology and abnormal cervical MRI/CT.

  20. [Environmental risk factors for schizophrenia: a review].

    Science.gov (United States)

    Vilain, J; Galliot, A-M; Durand-Roger, J; Leboyer, M; Llorca, P-M; Schürhoff, F; Szöke, A

    2013-02-01

    Evidence of variations in schizophrenia incidence rates has been found in genetically homogenous populations, depending on changes within time or space of certain environmental characteristics. The consideration of the impact of environmental risk factors in etiopathogenic studies has put the environment in the forefront of research regarding psychotic illnesses. Various environmental factors such as urbanicity, migration, cannabis, childhood traumas, infectious agents, obstetrical complications and psychosocial factors have been associated with the risk of developing schizophrenia. These risk factors can be biological, physical, psychological as well as social and may operate at different times in an individual's life (fetal period, childhood, adolescence and early adulthood). Whilst some of these factors act on an individual level, others act on a populational level, modulating the individual risk. These factors can have a direct action on the development of schizophrenia, or on the other hand act as markers for directly implicated factors that have not yet been identified. This article summarizes the current knowledge on this subject. An extensive literature search was conducted via the search engine Pubmed. Eight risk factors were selected and developed in the following paper: urbanicity (or living in an urban area), cannabis, migration (and ethnic density), obstetrical complications, seasonality of birth, infectious agents (and inflammatory responses), socio-demographic factors and childhood traumas. For each of these factors, we provide information on the importance of the risk, the vulnerability period, hypotheses made on the possible mechanisms behind the factors and the level of proof the current research offers (good, medium, or insufficient) according to the amount, type, quality and concordance of the studies at hand. Some factors, such as cannabis, are "unique" in their influence on the development of schizophrenia since it labels only one risk factor

  1. Relevant Affect Factors of Smartphone Mobile Data Traffic

    Directory of Open Access Journals (Sweden)

    Siniša Husnjak

    2016-08-01

    Full Text Available Smartphones are used to access a wide range of different information and communication services and perform functions based on data transfer. A number of subscription contracts for smartphones is rapidly increasing, and the development of mobile communications network provides higher speed of data transfer. The continuous increase in the average amount of data traffic per one subscriber contract leads to an increase in the total Mobile Data Traffic (MDT, globally. This research represents a summary of factors that affect the amount of smartphone MDT. Previous literature shows only a few of the factors individually that affect the realization of smartphone MDT. The results of the research clarify the ways which influence the amount of MDT generated by a smartphone. This paper increases the awareness of the users of the methods of generating smartphone MDT. The research also allows users to specify parameters that affect the prediction of generated MDT of a smartphone.

  2. General implications of research relevant to quality factors

    International Nuclear Information System (INIS)

    Dennis, J.A.

    1987-01-01

    Experiments on animals and mammalian cells in vitro support RBE values for fission neutrons relative low dose rate gamma radiation of about 20-30; and a dose rate reduction factor for low dose rate gamma radiation relative to high dose rates of between 2 to 10. Taken together these suggest that the risks from neutron and gamma radiation are not grossly underestimated in radiological protection. (author)

  3. Review of Antimicrobial Resistance in the Environment and its Relevance to Environmental Regulators

    Directory of Open Access Journals (Sweden)

    Andrew C Singer

    2016-11-01

    Full Text Available The environment is increasingly being recognised for the role it might play in the global spread of clinically-relevant antibiotic resistance. Environmental regulators monitor and control many of the pathways responsible for the release of resistance-driving chemicals into the environment (e.g., antimicrobials, metals, biocides. Hence, environmental regulators should be contributing significantly to the development of global and national antimicrobial resistance (AMR action plans. It is argued that the lack of environment-facing mitigation actions included in existing AMR action plans is likely a function of our poor fundamental understanding of many of the key issues. Here, we aim to present the problem with AMR in the environment through the lens of an environmental regulator, using the Environment Agency (England’s regulator as an example from which parallels can be drawn globally. The issues that are pertinent to environmental regulators are drawn out to answer: What are the drivers and pathways of AMR? How do these relate to the normal work, powers and duties of environmental regulators? What are the knowledge gaps that hinder the delivery of environmental protection from AMR? We offer several thought experiments for how different mitigation strategies might proceed. We conclude that: 1 AMR Action Plans do not tackle all the potentially relevant pathways and drivers of AMR in the environment; and 2 AMR Action Plans are deficient, in part, because the science to inform policy is lacking and this needs to be addressed.

  4. Determining Factors on Environmental Behaviour in Brasilia

    Directory of Open Access Journals (Sweden)

    Alexandre Nascimento de Almeida

    2015-12-01

    Full Text Available The growing concern about the environment has been changing the people's behaviour, leading to questions about the origin of products and the damage they cause to the environment, resulting in a new type of consumer, known as "green consumer". The purpose is to identify the influence of socio-demographic and psychographic factors on the environmental behaviour of individuals in the city of Brasilia and to provide information for the planning of environmental marketing strategies. Data were collected through a questionnaire and by way of logistic regression as analytical tools.The results indicated that the environmentally conscious individuals are those with higher levels of education and, especially, those who perceive the effectiveness of their environmental actions, however small or isolated.

  5. Environmental Factors, Toxicants and Systemic Lupus Erythematosus

    Directory of Open Access Journals (Sweden)

    Anselm Mak

    2014-09-01

    Full Text Available Systemic lupus erythematosus (SLE is an immune-complex-mediated multi-systemic autoimmune condition of multifactorial etiology, which mainly affects young women. It is currently believed that the onset of SLE and lupus flares are triggered by various environmental factors in genetically susceptible individuals. Various environmental agents and toxicants, such as cigarette smoke, alcohol, occupationally- and non-occupationally-related chemicals, ultraviolet light, infections, sex hormones and certain medications and vaccines, have been implicated to induce SLE onset or flares in a number case series, case-control and population-based cohort studies and very few randomized controlled trials. Here, we will describe some of these recognized environmental lupus triggering and perpetuating factors and explain how these factors potentially bias the immune system towards autoimmunity through their interactions with genetic and epigenetic alterations. Further in-depth exploration of how potentially important environmental factors mechanistically interact with the immune system and the genome, which trigger the onset of SLE and lupus flares, will certainly be one of the plausible steps to prevent the onset and to decelerate the progress of the disease.

  6. Environmental Factors Influencing Artisanal Fishing in Eastern ...

    African Journals Online (AJOL)

    user

    The study identified the environmental factors affecting artisanal fishing in. Eastern Obolo local government area of Akwa ... colonial administration (Anko &Eyo, 2003). According to Olomola (1998), artisanal ... The problems faced by artisanal fishers in Nigeria are not far from what is experienced by artisanal fishermen in ...

  7. Engineering tolerance to industrially relevant stress factors in yeast cell factories

    Science.gov (United States)

    Deparis, Quinten; Claes, Arne; Foulquié-Moreno, Maria R.

    2017-01-01

    Abstract The main focus in development of yeast cell factories has generally been on establishing optimal activity of heterologous pathways and further metabolic engineering of the host strain to maximize product yield and titer. Adequate stress tolerance of the host strain has turned out to be another major challenge for obtaining economically viable performance in industrial production. Although general robustness is a universal requirement for industrial microorganisms, production of novel compounds using artificial metabolic pathways presents additional challenges. Many of the bio-based compounds desirable for production by cell factories are highly toxic to the host cells in the titers required for economic viability. Artificial metabolic pathways also turn out to be much more sensitive to stress factors than endogenous pathways, likely because regulation of the latter has been optimized in evolution in myriads of environmental conditions. We discuss different environmental and metabolic stress factors with high relevance for industrial utilization of yeast cell factories and the experimental approaches used to engineer higher stress tolerance. Improving stress tolerance in a predictable manner in yeast cell factories should facilitate their widespread utilization in the bio-based economy and extend the range of products successfully produced in large scale in a sustainable and economically profitable way. PMID:28586408

  8. Engineering tolerance to industrially relevant stress factors in yeast cell factories.

    Science.gov (United States)

    Deparis, Quinten; Claes, Arne; Foulquié-Moreno, Maria R; Thevelein, Johan M

    2017-06-01

    The main focus in development of yeast cell factories has generally been on establishing optimal activity of heterologous pathways and further metabolic engineering of the host strain to maximize product yield and titer. Adequate stress tolerance of the host strain has turned out to be another major challenge for obtaining economically viable performance in industrial production. Although general robustness is a universal requirement for industrial microorganisms, production of novel compounds using artificial metabolic pathways presents additional challenges. Many of the bio-based compounds desirable for production by cell factories are highly toxic to the host cells in the titers required for economic viability. Artificial metabolic pathways also turn out to be much more sensitive to stress factors than endogenous pathways, likely because regulation of the latter has been optimized in evolution in myriads of environmental conditions. We discuss different environmental and metabolic stress factors with high relevance for industrial utilization of yeast cell factories and the experimental approaches used to engineer higher stress tolerance. Improving stress tolerance in a predictable manner in yeast cell factories should facilitate their widespread utilization in the bio-based economy and extend the range of products successfully produced in large scale in a sustainable and economically profitable way. © FEMS 2017.

  9. Factors Relevant to Utility Integration of Intermittent Renewable Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Wan, Y.; Parsons, B.

    1993-08-24

    This study assesses factors that utilities must address when they integrate intermittent renewable technologies into their power-supply systems; it also reviews the literature in this area and has a bibliography containing more than 350 listings. Three topics are covered: (1) interface (hardware and design-related interconnection), (2) operability/stability, and (3) planning. This study finds that several commonly held perceptions regarding integration of intermittent renewable energy technologies are not valid. Among fmdings of the study are the following: (1) hardware and system design advances have eliminated most concerns about interface, (2) cost penalties have not occurred at low to moderate penetration levels (and high levels am feasible); and (3) intermittent renewable energy technologies can have capacity values. Obstacles still interfering with intermittent renewable technologies are also indentified.

  10. Factors relevant to utility integration of intermittent renewable technologies

    Energy Technology Data Exchange (ETDEWEB)

    Wan, Yih-huei; Parsons, B.K.

    1993-08-01

    This study assesses factors that utilities must address when they integrate intermittent renewable technologies into their power-supply systems; it also reviews the literature in this area and has a bibliography containing more than 350 listings. Three topics are covered: (1) interface (hardware and design-related interconnection), (2) operability/stability, and (3) planning. This study finds that several commonly held perceptions regarding integration of intermittent renewable energy technologies are not valid. Among findings of the study are the following: (1) hardware and system design advances have eliminated most concerns about interface; (2) cost penalties have not occurred at low to moderate penetration levels (and high levels are feasible); and (3) intermittent renewable energy technologies can have capacity values. Obstacles still interfering with intermittent renewable technologies are also identified.

  11. Relevant principal factors affecting the reproducibility of insect primary culture.

    Science.gov (United States)

    Ogata, Norichika; Iwabuchi, Kikuo

    2017-06-01

    The primary culture of insect cells often suffers from problems with poor reproducibility in the quality of the final cell preparations. The cellular composition of the explants (cell number and cell types), surgical methods (surgical duration and surgical isolation), and physiological and genetic differences between donors may be critical factors affecting the reproducibility of culture. However, little is known about where biological variation (interindividual differences between donors) ends and technical variation (variance in replication of culture conditions) begins. In this study, we cultured larval fat bodies from the Japanese rhinoceros beetle, Allomyrina dichotoma, and evaluated, using linear mixed models, the effect of interindividual variation between donors on the reproducibility of the culture. We also performed transcriptome analysis of the hemocyte-like cells mainly seen in the cultures using RNA sequencing and ultrastructural analyses of hemocytes using a transmission electron microscope, revealing that the cultured cells have many characteristics of insect hemocytes.

  12. Potential CERCLA reauthorization issues relevant to US DOE's Environmental Restoration Program

    International Nuclear Information System (INIS)

    Siegel, M.R.; McKinney, M.D.; Jaksch, J.A.; Dailey, R.L.

    1993-02-01

    The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) is currently scheduled to be reauthorized in 1994. The US Department of Energy (DOE) has a significant stake in CERCLA reauthorization. CERCLA, along with its implementing regulation, the National Contingency Plan (NCP), is the principal legal authority governing DOE's environmental restoration program. The manner in which CERCLA-related issues are identified, evaluated, and dispatched may have a substantial impact on DOE's ability to conduct its environmental restoration program. A number of issues that impact DOE's environmental restoration program could be addressed through CERCLA reauthorization. These issues include the need to (1) address how the National Environmental Policy Act (NEPA) should be integrated into DOE CERCLA actions, (2) facilitate the streamlining of the Superfund process at DOE sites, (3) address the conflicts between the requirements of CERCLA and the Resource Conservation and Recovery Act (RCRA) that are especially relevant to DOE, (4) examine the criteria for waiving applicable or relevant and appropriate requirements (ARARs) at DOE sites, and (5) delineate the appropriate use of institutional controls at DOE sites

  13. Identifying the Relevant Factors in Newspaper Advertising Effectiveness

    Directory of Open Access Journals (Sweden)

    Cristóbal Benavides

    2014-01-01

    Full Text Available Este estudio explora varios factores con el fin de establecer cuáles son losmás importantes en motivar a los lectores de periódicos locales a comprar,visitar tiendas y buscar información adicional acerca de los productos oservicios promovidos en los anuncios. El comportamiento durante el pro-ceso de compra es consecuencia de una compleja interacción de dimen-siones culturales, sociales, personales y psicológicas. Este proceso –el cualse produce antes de la acción– tiene implicaciones relevantes y los depar-tamentos de mercadeo deben prestar atención a ello. Una serie de hipóte-sis basadas en la forma como la publicidad atrae a los consumidores y encómo afecta la toma de decisiones al momento de la compra fueron puestasa prueba usando una encuesta que fue administrada a una muestra de 1.333personas encuestadas en Chile. También se realizó un análisis discriminan-te para averiguar por qué algunos lectores de periódicos se ven motivadosa comprar bienes o servicios, visitar una tienda o buscar más información.Los resultados muestran que el atractivo de la oferta anunciada es el factormás importante para explicar el comportamiento posterior del consumidor.

  14. Exposure to environmentally-relevant levels of ozone negatively influence pollen and fruit development

    International Nuclear Information System (INIS)

    Gillespie, Colin; Stabler, Daniel; Tallentire, Eva; Goumenaki, Eleni; Barnes, Jeremy

    2015-01-01

    A combination of in vitro and in vivo studies on tomato (Lycopersicon esculentum Mill. cv. Triton) revealed that environmentally-relevant levels of ozone (O_3) pollution adversely affected pollen germination, germ tube growth and pollen-stigma interactions – pollen originating from plants raised in charcoal-Purafil"® filtered air (CFA) exhibited reduced germ tube development on the stigma of plants exposed to environmentally-relevant levels of O_3. The O_3-induced decline in in vivo pollen viability was reflected in increased numbers of non-fertilized and fertilized non-viable ovules in immature fruit. Negative effects of O_3 on fertilization occurred regardless of the timing of exposure, with reductions in ovule viability evident in O_3 × CFA and CFA × O_3 crossed plants. This suggests O_3-induced reductions in fertilization were associated with reduced pollen viability and/or ovule development. Fruit born on trusses independently exposed to 100 nmol mol"−"1 O_3 (10 h d"−"1) from flowering exhibited a decline in seed number and this was reflected in a marked decline in the weight and size of individual fruit – a clear demonstration of the direct consequence of the effects of the pollutant on reproductive processes. Ozone exposure also resulted in shifts in the starch and ascorbic acid (Vitamin C) content of fruit that were consistent with accelerated ripening. The findings of this study draw attention to the need for greater consideration of, and possibly the adoption of weightings for the direct impacts of O_3, and potentially other gaseous pollutants, on reproductive biology during ‘risk assessment’ exercises. - Highlights: • Environmentally-relevant levels of ozone exert negative effects on pollen viability that translate into direct impacts on fruit yield. • Negative impacts of O_3 pollution on reproductive processes were evident regardless of the stage of plant development. • Exposure to environmentally-relevant levels of O_3

  15. Engineering Design Handbook: Environmental Series. Part Three. Induced Environmental Factors

    Science.gov (United States)

    1976-01-20

    environmental factors. Rain will wash many pollutants from the atmosphere or winds will disperse them; rain or humidity will sup- press sand and dust...atmosphere (Ref. 11). (4) Air movement. Air movement serves to disperse 2-55 AMCP 70G-117 pollutants throughout the atmosphere. Airspeed and...CaCCL MgC03 MgCO^ Pure clay, kaolin , china clay Al203-2Si02.2H20 sand or dust environment includes (1) concentration (count or weight), (2

  16. The Genetic and Environmental Factors for Keratoconus

    Directory of Open Access Journals (Sweden)

    Ariela Gordon-Shaag

    2015-01-01

    Full Text Available Keratoconus (KC is the most common cornea ectatic disorder. It is characterized by a cone-shaped thin cornea leading to myopia, irregular astigmatism, and vision impairment. It affects all ethnic groups and both genders. Both environmental and genetic factors may contribute to its pathogenesis. This review is to summarize the current research development in KC epidemiology and genetic etiology. Environmental factors include but are not limited to eye rubbing, atopy, sun exposure, and geography. Genetic discoveries have been reviewed with evidence from family-based linkage analysis and fine mapping in linkage region, genome-wide association studies, and candidate genes analyses. A number of genes have been discovered at a relatively rapid pace. The detailed molecular mechanism underlying KC pathogenesis will significantly advance our understanding of KC and promote the development of potential therapies.

  17. Evidence of immunomodulation in nestling American kestrels (Falco sparverius) exposed to environmentally relevant PBDEs

    Energy Technology Data Exchange (ETDEWEB)

    Fernie, Kim J. [Canadian Wildlife Service, PO Box 5050, 867 Lakeshore Rd., Burlington, Ontario, L7R 4A6 (Canada)]. E-mail: kim.fernie@ec.gc.ca; Mayne, Greg [Canadian Wildlife Service, PO Box 5050, 867 Lakeshore Rd., Burlington, Ontario, L7R 4A6 (Canada); Shutt, J. Laird [National Wildlife Research Centre, Canadian Wildlife Service, 1125 Colonel By Drive, Ottawa, Ontario, K1S 5B6 (Canada); Pekarik, Cynthia [Canadian Wildlife Service, PO Box 5050, 867 Lakeshore Rd., Burlington, Ontario, L7R 4A6 (Canada); Grasman, Keith A. [Department of Biological Sciences, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH 45435 (United States); Letcher, Robert J. [National Wildlife Research Centre, Canadian Wildlife Service, 1125 Colonel By Drive, Ottawa, Ontario, K1S 5B6 (Canada); Great Lakes Institute for Environmental Research, University of Windsor, 401 Sunset Avenue, Windsor, Ontario, N9B 3P4 (Canada); Drouillard, Ken [Great Lakes Institute for Environmental Research, University of Windsor, 401 Sunset Avenue, Windsor, Ontario, N9B 3P4 (Canada)

    2005-12-15

    We investigated whether exposure to environmentally relevant polybrominated diphenyl ethers (PBDEs) causes immunomodulation in captive nestling American kestrels (Falco sparverius). Eggs within each clutch, divided by laying sequence, were injected with safflower oil or penta-BDE congeners-47, -99, -100, and -153 dissolved in safflower oil (18.7 {mu}g {sigma}PBDEs/egg) approximating Great Lakes birds. For 29 days, nestlings consumed the same PBDE mixture (15.6{+-}0.3 ng/g body weight per day), reaching {sigma}PBDE body burden concentrations that were 120x higher in the treatment birds (86.1{+-}29.1 ng/g ww) than controls (0.73{+-}0.5 ng/g ww). PBDE-exposed birds had a greater PHA response (T-cell-mediated immunity), which was negatively associated with increasing BDE-47 concentrations, but a reduced antibody-mediated response that was positively associated with increasing BDE-183 concentrations. There were also structural changes in the spleen (fewer germinal centers), bursa (reduced apoptosis) and thymus (increased macrophages), and negative associations between the spleen somatic index and {sigma}PBDEs, and the bursa somatic index and BDE-47. Immunomodulation from PBDE exposure may be exacerbated in wild birds experiencing greater environmental stresses. - Exposure to environmentally relevant polybrominated diphenyl ethers (congeners and concentrations) resulted in the immunomodulation of nestling American kestrels.

  18. Evidence of immunomodulation in nestling American kestrels (Falco sparverius) exposed to environmentally relevant PBDEs

    International Nuclear Information System (INIS)

    Fernie, Kim J.; Mayne, Greg; Shutt, J. Laird; Pekarik, Cynthia; Grasman, Keith A.; Letcher, Robert J.; Drouillard, Ken

    2005-01-01

    We investigated whether exposure to environmentally relevant polybrominated diphenyl ethers (PBDEs) causes immunomodulation in captive nestling American kestrels (Falco sparverius). Eggs within each clutch, divided by laying sequence, were injected with safflower oil or penta-BDE congeners-47, -99, -100, and -153 dissolved in safflower oil (18.7 μg ΣPBDEs/egg) approximating Great Lakes birds. For 29 days, nestlings consumed the same PBDE mixture (15.6±0.3 ng/g body weight per day), reaching ΣPBDE body burden concentrations that were 120x higher in the treatment birds (86.1±29.1 ng/g ww) than controls (0.73±0.5 ng/g ww). PBDE-exposed birds had a greater PHA response (T-cell-mediated immunity), which was negatively associated with increasing BDE-47 concentrations, but a reduced antibody-mediated response that was positively associated with increasing BDE-183 concentrations. There were also structural changes in the spleen (fewer germinal centers), bursa (reduced apoptosis) and thymus (increased macrophages), and negative associations between the spleen somatic index and ΣPBDEs, and the bursa somatic index and BDE-47. Immunomodulation from PBDE exposure may be exacerbated in wild birds experiencing greater environmental stresses. - Exposure to environmentally relevant polybrominated diphenyl ethers (congeners and concentrations) resulted in the immunomodulation of nestling American kestrels

  19. Manipulating Sensory and Phytochemical Profiles of Greenhouse Tomatoes Using Environmentally Relevant Doses of Ultraviolet Radiation.

    Science.gov (United States)

    Dzakovich, Michael P; Ferruzzi, Mario G; Mitchell, Cary A

    2016-09-14

    Fruits harvested from off-season, greenhouse-grown tomato plants have a poor reputation compared to their in-season, garden-grown counterparts. Presently, there is a gap in knowledge with regard to the role of UV-B radiation (280-315 nm) in determining greenhouse tomato quality. Knowing that UV-B is a powerful elicitor of secondary metabolism and not transmitted through greenhouse glass and some greenhouse plastics, we tested the hypothesis that supplemental UV-B radiation in the greenhouse will impart quality attributes typically associated with garden-grown tomatoes. Environmentally relevant doses of supplemental UV-B radiation did not strongly affect antioxidant compounds of fruits, although the flavonol quercetin-3-O-rutinoside (rutin) significantly increased in response to UV-B. Physicochemical metrics of fruit quality attributes and consumer sensory panels were used to determine if any such differences altered consumer perception of tomato quality. Supplemental UV-A radiation (315-400 nm) pre-harvest treatments enhanced sensory perception of aroma, acidity, and overall approval, suggesting a compelling opportunity to environmentally enhance the flavor of greenhouse-grown tomatoes. The expression of the genes COP1 and HY5 were indicative of adaptation to UV radiation, which explains the lack of marked effects reported in these studies. To our knowledge, these studies represent the first reported use of environmentally relevant doses of UV radiation throughout the reproductive portion of the tomato plant life cycle to positively enhance the sensory and chemical properties of fruits.

  20. The Value Relevance of Environmental, Social, and Governance Performance: The Brazilian Case

    Directory of Open Access Journals (Sweden)

    María Mar Miralles-Quirós

    2018-02-01

    Full Text Available There is extensive literature on the value relevance of social responsibility for companies that operate in developed countries. However, little is known about the influence of these practices on the price of assets listed on emerging economies, such as Brazil. In this context, the aim of this study is to analyse whether social responsibility activities carried out by companies listed on the São Paulo Stock Exchange during the 2010–2015 period play a significant role in enhancing firm value. Unlike previous studies, we distinguish between the three modern pillars of sustainability: environmental, social, and corporate governance (ESG. Our overall results support the value enhancing theory rather than the shareholder expense theory. However, it is important to note that the results also show that the market does not significantly value the three ESG pillars. Specifically, the market positively and significantly values the environmental practices carried out by companies not related to environmentally sensitive industries. In contrast, the market positively and significantly values the social and corporate governance practices carried out by the companies belonging to these sensitive industries. These findings are relevant for both investors and the managers of these companies, policy makers, customers, and citizens concerned about ESG issues.

  1. Environmental factors and elements of Ljig municipality

    Directory of Open Access Journals (Sweden)

    Miljanović Dragana

    2006-01-01

    Full Text Available In this paper some of the basic natural and social-geographic factors are analyzed, with the aim to identify their influence on the environmental status. Qualitative assessment are attempted about the various elements of the environment, and attention directed to the problems of noise, and problems of communal waste disposal. A synthetic presentation of the environmental status in the municipality of Ljig is given. The territory of Ljig has been spatially differentiated, namely, it has been categorized according to the degree of pollution. High concentration of the population, and activities, in the town Ljig itself has produced a degradation worse than in the other settlements. On the other hand, the settlements in which is situated the locationally non-flexible industry (quarrying and processing of stone are facing problems of other sort. In the villages, however, which are slowly becoming depopulated, the quality of the environment is satisfactory. In accordance with such facts, revealed about the environmental status, basic aims have been defined as to how to protect the environment in the future. For the realization of environmental aims, various measures and activities are being proposed, with the purpose to improve the situation in the threatened zones, and to safeguard the quality of the environment on the entire municipal territory of Ljig.

  2. Asthma and Environmental Factors in Children

    Directory of Open Access Journals (Sweden)

    Mirzadeh M.

    2016-10-01

    Full Text Available Asthma is one of the most prevalent atopic diseases in childhood. It is characterized by inflammation of conductive airways and bronchial hyperresponsiveness. Environmental factors introduced to child in early years of life may have a protective or harmful role in developing atopic diseases. To evaluate the influence of some environmental factors such as cat or dog ownership, smoking of mother or father and environmental pollution on prevalence of wheezing in children. Subjects and methods: This was a cross sectional retrospective study. A questionnaire was designed based on International Study of Asthma and Allergies in Childhood (ISAAC. Parents of the subjects were asked to fill in the questionnaires. Children’s wheezing association with keeping cats and dogs, smoking mother and father and frequency of truck passing in place of residence was investigated. 545 children were recruited in our study. Prevalence of wheezing was 9%. Keeping cats in first year of life and last year was associated with less wheezing. But the latter association was not statistically significant. Keeping dogs was so scarce in area of our study, so we could not perform a rightful analysis. Frequency of truck passing was significantly higher in those with wheezing. Keeping cats in first year of life was a significant protective factor, whereas residence in an area with frequent truck passing increased wheezing in children. Results of our study can emphasize the need to keep children away from polluted areas. Further studies are needed to investigate whether keeping a pet in household can benefit children regarding all possible concerns and benefits.

  3. Environmental risk assessment of biocidal products: identification of relevant components and reliability of a component-based mixture assessment.

    Science.gov (United States)

    Coors, Anja; Vollmar, Pia; Heim, Jennifer; Sacher, Frank; Kehrer, Anja

    2018-01-01

    Biocidal products are mixtures of one or more active substances (a.s.) and a broad range of formulation additives. There is regulatory guidance currently under development that will specify how the combined effects of the a.s. and any relevant formulation additives shall be considered in the environmental risk assessment of biocidal products. The default option is a component-based approach (CBA) by which the toxicity of the product is predicted from the toxicity of 'relevant' components using concentration addition. Hence, unequivocal and practicable criteria are required for identifying the 'relevant' components to ensure protectiveness of the CBA, while avoiding unnecessary workload resulting from including by default components that do not significantly contribute to the product toxicity. The present study evaluated a set of different criteria for identifying 'relevant' components using confidential information on the composition of 21 wood preservative products. Theoretical approaches were complemented by experimentally testing the aquatic toxicity of seven selected products. For three of the seven tested products, the toxicity was underestimated for the most sensitive endpoint (green algae) by more than factor 2 if only the a.s. were considered in the CBA. This illustrated the necessity of including at least some additives along with the a.s. Considering additives that were deemed 'relevant' by the tentatively established criteria reduced the underestimation of toxicity for two of the three products. A lack of data for one specific additive was identified as the most likely reason for the remaining toxicity underestimation of the third product. In three other products, toxicity was overestimated by more than factor 2, while prediction and observation fitted well for the seventh product. Considering all additives in the prediction increased only the degree of overestimation. Supported by theoretical calculations and experimental verifications, the present

  4. Factors for formulating strategies for environmental restoration

    International Nuclear Information System (INIS)

    1998-07-01

    This publication focusses on factors which are important for formulating a strategy for environmental restoration. In parallel to this effort, the IAEA has conducted activities in related areas which have been reported in companion reports dealing with (1) the characterization of radioactively contaminated sites for remediation purposes and (2) available technology for cleanup and remediation of radioactively contaminated sites. Additionally, follow-up activities will focus on two other areas, viz. planning and management options for cleanup of contaminated groundwater, and post-restoration monitoring of decommissioned sites. In a separate initiative the IAEA has developed preliminary guidance on radiological criteria for determining when cleanup action is needed and for deciding on when areas have been cleaned up to a sufficient extent. It is also concerned with radioactive contamination of soils, groundwaters, structures and biota which may have the potential for harm to people. It is intended that it will serve as an important source of information and data on the key factors to be considered in the formulation of an environmental restoration strategy

  5. Environmental Factors Affecting Where People Geocache

    Directory of Open Access Journals (Sweden)

    Jennifer Golbeck

    2016-04-01

    Full Text Available Outdoor leisure activities are important for public health as well as family cohesiveness, yet environmental factors may easily affect someone’s ability to participate in such activities. We explored this with a focus on the social web-based treasure hunt game called Geocaching. We collected data on all US and Canadian geocaches from OpenCaching.com and conducted an online survey with twenty geocachers as a follow-up to our data analysis. Data analysis showed that geocaches were more often found in areas that were wealthier, better educated, younger, and more urban, and had higher population density and better weather. Survey results showed similar trends: Most people actively thought about where they would cache and tried to minimize risks, despite cache hiders thinking less about these concerns. These results further emphasize the importance of environmental factors when it comes to participation in outdoor activities and leads to Human–Computer Interaction design implications for location-based online social activities.

  6. Exposome in IBD: recent insights in environmental factors that influence the onset and course of IBD.

    Science.gov (United States)

    Rogler, Gerhard; Vavricka, Stephan

    2015-02-01

    It is generally agreed that environmental factors trigger the onset and cause flares of inflammatory bowel disease. Although we have learned much about genetic susceptibility factors of inflammatory bowel disease in recent years, our knowledge on these environmental factors is limited. The sum of all environmental factors a human is exposed to during lifetime has been termed the exposome. The challenge of investigating the exposome is discussed in this overview. The environmental exposure of a subject causes changes in the intestinal microbiota and subsequently changes the epigenetic imprinting of the mucosa and the associated immune system. Some relevant environmental factors have been investigated in recent years in inflammatory bowel disease and other (auto)inflammatory disease. These factors can be categorized in air pollution, diet, drugs, stress, infections, water pollution, food additives, and lifestyle. Examples from those categories and their potential pathophysiological mechanism are discussed.

  7. Marble wastes and pig slurry improve the environmental and plant-relevant properties of mine tailings.

    Science.gov (United States)

    Kabas, S; Faz, A; Acosta, J A; Arocena, J M; Zornoza, R; Martínez-Martínez, S; Carmona, D M

    2014-02-01

    Poor soil fertility is often the biggest challenge to the establishment of vegetation in mine wastes deposits. We conducted field trials in the El Gorguel and El Lirio sites in SE Spain, two representative tailing ponds of similar properties except for pH, to understand the environmental and plant-relevant benefits of marble waste (MW) and pig slurry (PS) applications to mine tailings. Low pH (5.4) tailings (El Lirio) exhibit reduction of up to fourfold in bio-availability of metals as shown by the DTPA-Zn, Pb, water-soluble Zn, Pb and up to 3× for water-soluble Cd. Tailings in El Gorguel have high pH (7.4) and did not exhibit significant trends in the reductions of water-extractable Zn, Pb, Cd and Cu. Improvements to the edaphic (plant-relevant) properties of tailings after the amendments are not as sensitive to pH compared to the environmental characteristics. The two sites had increases in aggregate stability, organic matter (total N and organic C) although total N is higher in the El Gorguel (up to 212 μg N kg(-1)) than the El Lirio (up to 26 μg N kg(-1)). However, cation exchange capacities are similar in both sites at 15.2 cmol(+) kg(-1). We conclude that the characteristics, especially pH, of tailing materials significantly influence the fate of metals but not improvements to plant-relevant properties such as cation exchange capacity and aggregate stability 1 year after the application of MW and PS amendments.

  8. Environmental restoration disposal facility applicable or relevant and appropriate requirements study report. Revision 00

    International Nuclear Information System (INIS)

    Roeck, F.V.; Vedder, B.L.; Rugg, J.E.

    1995-10-01

    The Environmental Restoration Disposal Facility (ERDF) will be a landfill authorized under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) and will comply with the Resource Conservation and Recovery Act of 1976 (RCRA) substantive requirements. The facility will also comply with applicable or relevant and appropriate requirements (ARAR), including portions of the U.S. Environmental Protection Agency (EPA) regulations, Washington Administrative Code (WAC), and to-be-considered (TBC) elements such as U.S. Department of Energy (DOE) Orders. In considering the requirements of CERCLA, a detailed analysis of various alternatives for ERDF was completed using the nine CERCLA criteria, National Environmental Policy Act of 1969 (NEPA), and public comments. The ERDF record of decision (ROD) selected an alternative that includes a RCRA-compliant double-lined trench for the disposal of radioactive, hazardous, and mixed wastes resulting from the remediation of operable units (OU) within the National Priorities List (NPL) sites in the 100, 200, and 300 Areas. Only wastes resulting from the remediation of Hanford NPL sites will be allowed in the ERDF. Of the various siting and design alternatives proposed for ERDF, the selected alternative provides the best combination of features by balancing the nine CERCLA criteria, ARAR compliance, environmentally protective site, and various stakeholder and public recommendations. The ERDF trench design, compliant with RCRA Subtitle C minimum technical requirements (MTR), will be double lined and equipped with a leachate collection system. This design provides a more reliable system to protect groundwater than other proposed alternatives. The ERDF is located on the Hanford Site Central Plateau, southeast of the 200 West Area

  9. Potential for use of environmental factors in urban planning

    Science.gov (United States)

    Teixeira da Silva, Ricardo; van der Ploeg, Martine; van Delden, Hedwig; Fleskens, Luuk

    2016-04-01

    Projections for population growth estimate, on top of the current 7.4 billion world population, an increase of 2 billion people for the next 40 years. It is also projected that 66 per cent of the world population in 2050 will live in urban areas. To accommodate the urban population growth cities are changing continuously land cover to urban areas. Such changes are a threat for natural resources and food production systems stability and capability to provide food and other functions. However, little has been done concerning a rational soil management for food production in urban and peri-urban areas. This study focuses on the assessment of soil lost due to urban expansion and discusses the potential loss regarding the quality of the soil for food production and environmental functions. It is relevant to increase the knowledge on the role of soils in peri-urban areas and in the interaction of physical, environmental and social factors. The methodology consists of assessing the soil quality in and around urban and peri-urban areas. It focuses particularly on the physical properties and the environmental factors, for two periods of time and account the potential losses due to urban expansion. This project is on-going, therefore current advances will be presented and will look for a discussion on the contribution of soil quality for decision-making and land management in urban and peri-urban areas.

  10. Aspects relevant to safety and environmental protection correlated with nuclear technology

    International Nuclear Information System (INIS)

    Naschi, G.

    1992-01-01

    This paper analyzes the evolution of the most relevant aspects of safety and environmental protection as fundamental elements of the development of nuclear energy in the international framework. The stages leading to the preventive approach to safety in the fifties and in the sixties are also highlighted. During these years, the 'defence in depth' principle was established as the basis for the consequent evolution of the nuclear safety regulations. In this context accident prevention was entrusted to a highly reliable set of redundant systems that could be passive or actuated in a manual or automatic way. In the 1970's, following the accidents of Browns Ferry and Three Mile Island nuclear power plants, an impulse was given to the systematic safety assessment and to the trend of the so-called Probabilistic Risk Assessment (PRA). The paper takes into account the aspects of risk perception as the social effect of Three Mile Island and Chernobyl accidents. This subject has led both to public awareness about the chronic and traumatic risk deriving from a severe accident and, in the international framework, to a process of plants design optimization towards safety and environmental protection. The general aspects of safety and environmental protection are then completed by an overview of the regulatory policies, with particular reference to the licensing procedures developed in Italy

  11. Human health and the environment: Predicting plasma protein binding and metabolic clearance rates of environmentally relevant chemicals.

    Science.gov (United States)

    In silico methods provide a rapid, inexpensive means of screening a wide array of environmentally relevant pollutants, pesticides, fungicides and consumer products for further toxicity testing. Physiologically based pharmacokinetic (PBPK) models bridge the gap between in vitro as...

  12. Environmental problem-solving: Psychosocial factors

    Science.gov (United States)

    Miller, Alan

    1982-11-01

    This is a study of individual differences in environmental problem-solving, the probable roots of these differences, and their implications for the education of resource professionals. A group of student Resource Managers were required to elaborate their conception of a complex resource issue (Spruce Budworm management) and to generate some ideas on management policy. Of particular interest was the way in which subjects dealt with the psychosocial aspects of the problem. A structural and content analysis of responses indicated a predominance of relatively compartmentalized styles, a technological orientation, and a tendency to ignore psychosocial issues. A relationship between problem-solving behavior and personal (psychosocial) style was established which, in the context of other evidence, suggests that problem-solving behavior is influenced by more deep seated personality factors. The educational implication drawn was that problem-solving cannot be viewed simply as an intellectual-technical activity but one that involves, and requires the education of, the whole person.

  13. Effects of tributyltin on metamorphosis and gonadal differentiation of Xenopus laevis at environmentally relevant concentrations.

    Science.gov (United States)

    Shi, Huahong; Zhu, Pan; Guo, Suzhen

    2014-05-01

    Tributyltin (TBT), a well known endocrine disruptor, has high teratogenicity to embryos of amphibian (Xenopus tropicalis). An amphibian metamorphosis assay (AMA) and a complete AMA (CAMA) were conducted for TBT. In AMA, the body weight, the snout-to-vent length and the hind limb length of X. laevis tadpoles were decreased in tributyltin chloride (TBTCl; 12.5-200 ng/L) treatment groups after 7 days exposure. TBT greatly retarded the development of tadpoles, decreased the number of follicle and induced thyroid follicle cell hyperplasia after 19 days exposure. In CAMA, 10 and 100 ng/L TBTCl led to various malformations of gonad, including intersex, segmental aplasia and multiple ovary cavities of X. laevis following exposure from stages 46 to stage 66. The sex ratio was male-biased in TBT treatment groups. These results suggest that TBT delayed the metamorphosis, inhibited the growth of tadpoles and disrupted the gonadal differentiation of X. laevis at environmentally relevant concentrations.

  14. Campylobacter species in animal, food, and environmental sources, and relevant testing programs in Canada.

    Science.gov (United States)

    Huang, Hongsheng; Brooks, Brian W; Lowman, Ruff; Carrillo, Catherine D

    2015-10-01

    Campylobacter species, particularly thermophilic campylobacters, have emerged as a leading cause of human foodborne gastroenteritis worldwide, with Campylobacter jejuni, Campylobacter coli, and Campylobacter lari responsible for the majority of human infections. Although most cases of campylobacteriosis are self-limiting, campylobacteriosis represents a significant public health burden. Human illness caused by infection with campylobacters has been reported across Canada since the early 1970s. Many studies have shown that dietary sources, including food, particularly raw poultry and other meat products, raw milk, and contaminated water, have contributed to outbreaks of campylobacteriosis in Canada. Campylobacter spp. have also been detected in a wide range of animal and environmental sources, including water, in Canada. The purpose of this article is to review (i) the prevalence of Campylobacter spp. in animals, food, and the environment, and (ii) the relevant testing programs in Canada with a focus on the potential links between campylobacters and human health in Canada.

  15. Seasonal variation in human reproduction: environmental factors.

    Science.gov (United States)

    Bronson, F H

    1995-06-01

    Almost all human populations exhibit seasonal variation in births, owing mostly to seasonal variation in the frequency of conception. This review focuses on the degree to which environmental factors like nutrition, temperature and photoperiod contribute to these seasonal patterns by acting directly on the reproductive axis. The reproductive strategy of humans is basically that of the apes: Humans have the capacity to reproduce continuously, albeit slowly, unless inhibited by environmental influences. Two, and perhaps three, environmental factors probably act routinely as seasonal inhibitors in some human populations. First, it seems likely that ovulation is regulated seasonally in populations experiencing seasonal variation in food availability. More specifically, it seems likely that inadequate food intake or the increased energy expenditure required to obtain food, or both, can delay menarche, suppress the frequency of ovulation in the nonlactating adult, and prolong lactational amenorrhea in these populations on a seasonal basis. This action is most easily seen in tropical subsistence societies where food availability often varies greatly owing to seasonal variation in rainfall; hence births in these populations often correlate with rainfall. Second, it seems likely that seasonally high temperatures suppress spermatogenesis enough to influence the incidence of fertilization in hotter latitudes, but possibly only in males wearing clothing that diminishes scrotal cooling. Since most of our knowledge about this phenomenon comes from temperate latitudes, the sensitivity of spermatogenesis in both human and nonhuman primates to heat in the tropics needs further study. It is quite possible that high temperatures suppress ovulation and early embryo survival seasonally in some of these same populations. Since we know less than desired about the effect of heat stress on ovulation and early pregnancy in nonhuman mammals, and nothing at all about it in humans or any of the

  16. Knowledge, Internal, and Environmental Factors on Environmental Care Behaviour among Aboriginal Students in Malaysia

    Science.gov (United States)

    Rahman, Norshariani Abd

    2016-01-01

    This study determined the contribution of predictor factors (i.e. knowledge about the environment as well as internal and environmental factors) on environmental care behaviour among aboriginal students. The knowledge about the environment that was investigated in this research includes environmental knowledge and environmental action knowledge.…

  17. Exposure to environmentally-relevant levels of ozone negatively influence pollen and fruit development.

    Science.gov (United States)

    Gillespie, Colin; Stabler, Daniel; Tallentire, Eva; Goumenaki, Eleni; Barnes, Jeremy

    2015-11-01

    A combination of in vitro and in vivo studies on tomato (Lycopersicon esculentum Mill. cv. Triton) revealed that environmentally-relevant levels of ozone (O3) pollution adversely affected pollen germination, germ tube growth and pollen-stigma interactions - pollen originating from plants raised in charcoal-Purafil(®) filtered air (CFA) exhibited reduced germ tube development on the stigma of plants exposed to environmentally-relevant levels of O3. The O3-induced decline in in vivo pollen viability was reflected in increased numbers of non-fertilized and fertilized non-viable ovules in immature fruit. Negative effects of O3 on fertilization occurred regardless of the timing of exposure, with reductions in ovule viability evident in O3 × CFA and CFA × O3 crossed plants. This suggests O3-induced reductions in fertilization were associated with reduced pollen viability and/or ovule development. Fruit born on trusses independently exposed to 100 nmol mol(-1) O3 (10 h d(-1)) from flowering exhibited a decline in seed number and this was reflected in a marked decline in the weight and size of individual fruit - a clear demonstration of the direct consequence of the effects of the pollutant on reproductive processes. Ozone exposure also resulted in shifts in the starch and ascorbic acid (Vitamin C) content of fruit that were consistent with accelerated ripening. The findings of this study draw attention to the need for greater consideration of, and possibly the adoption of weightings for the direct impacts of O3, and potentially other gaseous pollutants, on reproductive biology during 'risk assessment' exercises. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Prenatal exposure to an environmentally relevant phthalate mixture disrupts reproduction in F1 female mice

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Changqing; Gao, Liying; Flaws, Jodi A., E-mail: jflaws@illinois.edu

    2017-03-01

    Phthalates are used in a large variety of products, such as building materials, medical devices, and personal care products. Most previous studies on the toxicity of phthalates have focused on single phthalates, but it is also important to study the effects of phthalate mixtures because humans are exposed to phthalate mixtures. Thus, we tested the hypothesis that prenatal exposure to an environmentally relevant phthalate mixture adversely affects female reproduction in mice. To test this hypothesis, pregnant CD-1 dams were orally dosed with vehicle (tocopherol-stripped corn oil) or a phthalate mixture (20 and 200 μg/kg/day, 200 and 500 mg/kg/day) daily from gestational day 10 to birth. The mixture was based on the composition of phthalates detected in urine samples from pregnant women in Illinois. The mixture included 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% diisononyl phthalate, 8% diisobutyl phthalate, and 5% benzylbutyl phthalate. Female mice born to the exposed dams were subjected to tissue collections and fertility tests at different ages. Our results indicate that prenatal exposure to the phthalate mixture significantly increased uterine weight and decreased anogenital distance on postnatal days 8 and 60, induced cystic ovaries at 13 months, disrupted estrous cyclicity, reduced fertility-related indices, and caused some breeding complications at 3, 6, and 9 months of age. Collectively, our data suggest that prenatal exposure to an environmentally relevant phthalate mixture disrupts aspects of female reproduction in mice. - Highlights: • Prenatal exposure to a phthalate mixture disrupts F1 estrous cyclicity. • Prenatal exposure to a phthalate mixture induces F1 ovarian cysts. • Prenatal exposure to a phthalate mixture decreases F1 female fertility-related indices. • Prenatal exposure to a phthalate mixture induces F1 breeding complications.

  19. Environmental Factors that Interfere in the Germination

    Directory of Open Access Journals (Sweden)

    Lisiane de Souza

    2014-12-01

    Full Text Available This paper refers to the application of experiments with sixth graders of elementary school, aiming motivation, skills development focused on observation, interpersonal relationships in teams, related to the various forms of language skills, as well to identify and resume misconceptions about the external (environmental factors required for seed germination, in order that the contents developed this year refer to the study of the earth, soil, water and air, among others, and that many students do not understand all the concepts and the importance of these factors for the existence of living beings. The experiments were organized in two stages, first to observe the influence of soil and another moment to observe the interference of water, air and light. The temperature impractical activities were conducted, however, during the observation period (three weeks experiments remained in a controlled environment in the science laboratory. For the experiments we used materials easily found in commerce, some recycled; students were organized into six teams, which improved the data collection, the maintenance of the experiments, the calculations of the percentages, and the producing of report. Many of these contents had not yet been studied in other disciplines, but were developed in the discipline of science, respecting prior knowledge and cognitive abilities. The use of experiments was effective for the construction of new knowledge and to develop skills necessary to start the search.

  20. Environmentally relevant concentrations of citalopram partially inhibit feeding in the three-spine stickleback (Gasterosteus aculeatus).

    Science.gov (United States)

    Kellner, M; Porseryd, T; Porsch-Hällström, I; Hansen, S H; Olsén, K H

    2015-01-01

    Selective Serotonin Re-uptake Inhibitors (SSRI) are mood-altering, psychotropic drugs commonly used in the treatment of depression and other psychological illnesses. Many of them are poorly degraded in sewage treatment plants and enter the environment unaltered. In laboratory studies, they have been demonstrated to affect a wide range of behaviours in aquatic organisms. In this study we investigated the effect of a three-week exposure to 0.15 and 1.5 μg/l of the SSRI citalopram dissolved in the ambient water on the feeding behaviour in three-spine stickleback (Gasterosteus aculeatus). Feeding, measured as the number of attacks performed on a piece of frozen bloodworms during a 10-min period, was reduced by 30-40% in fish exposed to both 0.15 and 1.5 μg/l citalopram. The effects of the environmentally relevant concentration 0.15 μg/l on feeding, an important fitness characteristic, suggests that the ecological significance of environmental SSRI exposure may be pronounced. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. [Determination of priority unfavorable environmental factors].

    Science.gov (United States)

    Zaikova, Z A; Burdukovskaya, A V; Belykh, A I

    In the Irkutsk region there are recorded high indices of rates of morbidity, disability, mortality rate of the working-age population and low levels of life expectancy of the population, that is confirmed by ranking position levels among the all subjects of the Russian Federation. According to all mentioned indices of health the region is inside the top ten unfavorable regions of Russia. In relation to the problem in the state of health of the adult population the estimation of the causal relationships between environmental factors and certain health indices is actual. The list of studiedfactors included health indices that characterize the harmful working conditions of the working population and basic socioeconomic indices in the region. Estimation of causal-relationship relationships was performed with the use of methods of multivariate analysis - correlation and multiple linear regression. In the selection offactors for the construction of mathematical models of multiple regression there were used methods of the analysis of variables variability, pair correlation coefficients matrix and sequential switching covariates to eliminate the problems of multicollinearity, pre-standardization of indices for the elevation of the numerical stability of regression analysis algorithm. As a result of the execution of the analysis there were constructed statistical models for the dependence in the system variables “environment - public health”, which allowed to identify the most informative regression models for the adult population health according to indices of primary disability of the population, the mortality rate and life expectancy of the working age population. According to results of the analysis there were identified priority factors affecting on the health of the adult population of the Irkutsk region. To these factors there are referred the proportion of workplaces failing to meet sanitary standards for vibration and 8 socio-economic indices of living

  2. Influence of bioregion and environmental factors on the growth, size ...

    African Journals Online (AJOL)

    The influence of bioregion and important environmental factors in South Africa ... the production efficiency of cows through the implementation of management ... genetic component was not separated from the environmental components.

  3. Clinical relevance of and risk factors associated with medication administration time errors

    NARCIS (Netherlands)

    Teunissen, R.; Bos, J.; Pot, H.; Pluim, M.; Kramers, C.

    2013-01-01

    PURPOSE: The clinical relevance of and risk factors associated with errors related to medication administration time were studied. METHODS: In this explorative study, 66 medication administration rounds were studied on two wards (surgery and neurology) of a hospital. Data on medication errors were

  4. A review of potential factors relevant to coping in patients with advanced cancer

    DEFF Research Database (Denmark)

    Thomsen, Thora G.; Rydahl-Hansen, Susan; Wagner, Lis

    2010-01-01

    The aim was to identify characteristics that are considered to describe coping in patients with advanced cancer, as seen from a patient perspective. Based on the identified characteristics, the second aim was to identify potential factors that are relevant to coping in patients with advanced cancer....

  5. Identifying the Relevant Local Population for Environmental Impact Assessments of Mobile Marine Fauna

    Directory of Open Access Journals (Sweden)

    Delphine B. H. Chabanne

    2017-05-01

    Full Text Available Environmental impact assessments must be addressed at a scale that reflects the biological organization for the species affected. It can be challenging to identify the relevant local wildlife population for impact assessment for those species that are continuously distributed and highly mobile. Here, we document the existence of local communities of Indo-Pacific bottlenose dolphins (Tursiops aduncus inhabiting coastal and estuarine waters of Perth, Western Australia, where major coastal developments have been undertaken or are proposed. Using sighting histories from a 4-year photo-identification study, we investigated fine-scale, social community structure of dolphins based on measures of social affinity, and network (Half-Weight Index—HWI, preferred dyadic association tests, and Lagged Association Rates—LAR, home ranges, residency patterns (Lagged Identification Rates—LIR, and genetic relatedness. Analyses revealed four socially and spatially distinct, mixed-sex communities. The four communities had distinctive social patterns varying in strength, site fidelity, and residency patterns. Overlap in home ranges and relatedness explained little to none of the association patterns between individuals, suggesting complex local social structures. The study demonstrated that environmental impact assessments for mobile, continuously distributed species must evaluate impacts in light of local population structure, especially where proposed developments may affect core habitats of resident communities or sub-populations. Here, the risk of local extinction is particularly significant for an estuarine community because of its small size, limited connectivity with adjacent communities, and use of areas subject to intensive human use. In the absence of information about fine-scale population structure, impact assessments may fail to consider the appropriate biological context.

  6. How cyclophosphamide at environmentally relevant concentration influences Daphnia magna life history and its proteome.

    Directory of Open Access Journals (Sweden)

    Małgorzata Grzesiuk

    Full Text Available The waste of commonly used medicines is known to contaminate freshwater ecosystems. Pharmaceuticals can be toxic, mutagenic, or modifying to freshwater organisms even at low concentrations if consider their permanent presence in the environment. Chemotherapeutics used to treat cancer, and in particular alkylating agents, contribute significantly to this form of pollution, the latter introducing cytotoxic and/or mutagenic lesions to the DNA and RNA of organisms which can be disruptive to their cells. The aim of the present study was to investigate the influence of the alkylating anticancer agent cyclophosphamide (CP on Daphnia magna clones. We evaluated the life history parameters and protein profiles of this crustacean following exposure to environmentally relevant CP concentration of 10 ng L-1. Even at this low concentration, the alkylating agent caused modification of the life history parameters and proteome profile of the Daphnia. These changes were clone-specific and involved growth rate, age at first reproduction, neonate number, and proteins related to cell cycle and redox state regulation. The disturbance caused by pharmaceuticals contaminating freshwater ecosystem is probably weaker and unlikely to be cytotoxic in character due to the high dilution of these substances in the water. However, our results indicate that prolonged exposure of organisms to these toxins may lead to modifications on the organismal and molecular levels with unpredictable significance for the entire ecosystem.

  7. Data on environmentally relevant level of aflatoxin B1-induced human dendritic cells' functional alteration

    Directory of Open Access Journals (Sweden)

    Jalil Mehrzad

    2018-06-01

    Full Text Available We assessed the effects of naturally occurring levels of AFB1 on the expression of key immune molecules and function of human monocyte-derived dendritic cells (MDDCs by cell culture, RT-qPCR, and flow cytometry. Data here revealed that an environmentally relevant level of AFB1 led to remarkably weakened key functional capacity of DCs, up-regulation of key transcripts and DCs apoptosis, down-regulation of key phagocytic element, CD64, and creation of pseudolicensing direction of DCs. Flow cytometry data confirmed a damage towards DCs, i.e., increased apoptosis. The detailed data and their mechanistic effects and the outcome are available in this research article (Mehrzad et al., 2018 [1]. The impaired phagocytosis capacity with triggered pseudolicensing direction of MDDCs caused by AFB1 and dysregulation of the key functional genes could provide a mechanistic explanation for the observed in vivo immunotoxicity associated with this mycotoxin. Keywords: AFB1, Apoptosis, AFB1-detoxifying genes, Dendritic cells, Flow cytometry, Functional genes, Immunnoderegulation, Phagocytosis, RT-qPCR

  8. Effects of environmentally relevant concentrations of atrazine on gonadal development of snapping turtles (Chelydra serpentina).

    Science.gov (United States)

    de Solla, Shane R; Martin, Pamela A; Fernie, Kimberly J; Park, Brad J; Mayne, Gregory

    2006-02-01

    The herbicide atrazine has been suspected of affecting sexual development by inducing aromatase, resulting in the increased conversion of androgens to estrogens. We used snapping turtles (Chelydra serpentina), a species in which sex is dependent on the production of estrogen through aromatase activity in a temperature-dependent manner, to investigate if environmentally relevant exposures to atrazine affected gonadal development. Eggs were incubated in soil to which atrazine was applied at a typical field application rate (3.1 L/ha), 10-fold this rate (31 L/ha), and a control rate (no atrazine) for the duration of embryonic development. The incubation temperature (25 degrees C) was selected to produce only males. Although some males with testicular oocytes and females were produced in the atrazine-treated groups (3.3-3.7%) but not in the control group, no statistical differences were found among treatments. Furthermore, snapping turtle eggs collected from natural nests in a corn field were incubated at the pivotal temperature (27.5 degrees C) at which both males and females normally would be produced, and some males had oocytes in the testes (15.4%). The presence of low numbers of males with oocytes may be a natural phenomenon, and we have limited evidence to suggest that the presence of normal males with oocytes may represent a feminizing effect of atrazine. Histological examination of the thyroid gland revealed no effect on thyroid morphology.

  9. Effects of tributyltin (TBT) on Xenopus tropicalis embryos at environmentally relevant concentrations.

    Science.gov (United States)

    Guo, Suzhen; Qian, Lijuan; Shi, Huahong; Barry, Terence; Cao, Qinzhen; Liu, Junqi

    2010-04-01

    Tributyltin (TBT) has been widely used as a biocide in antifouling paints and is a known endocrine disrupting chemical. In this paper, we exposed embryos of Xenopus tropicalis to 50-400ngL(-1) tributyltin chloride. TBT significantly decreased the survival rate, reduced the body length and retarded the development of embryos after 24, 36 and 48h of exposure. These effects of TBT were concentration- and time-dependent. Embryos treated with TBT showed multiple malformations. The most obvious alterations were abnormal eyes, enlarged proctodaeum, narrow fins, and skin hypopigmentation. Enlarged proctodaeum and narrow fins were mainly observed after 36 and 48h of exposure. The loss of eye pigmentation or the absence of external eyes occurred after 24 and 36h of exposure, while extended lenses or edemas of eyes were more commonly observed after 48h of exposure. Additional malformations included: small anterior region of heads, pericardial edemas, enlarged trunks, and bent tails. These results suggested that TBT is very toxic to X. tropicalis embryos at environmentally relevant concentrations.

  10. Altered pairing behaviour and reproductive success in white ibises exposed to environmentally relevant concentrations of methylmercury.

    Science.gov (United States)

    Frederick, Peter; Jayasena, Nilmini

    2011-06-22

    Methylmercury (MeHg) is the most biologically available and toxic form of mercury, and can act as a powerful teratogen, neurotoxin and endocrine disruptor in vertebrates. However, mechanisms of endocrine impairment and net effects on demography of biota are poorly understood. Here, we report that experimental exposure of an aquatic bird over 3 years to environmentally relevant dietary MeHg concentrations (0.05-0.3 ppm wet weight) resulted in dose-related increases in male-male pairing behaviour (to 55% of males), and decreases in egg productivity (to 30%). Dosed males showed decreased rates of key courtship behaviours, and were approached less by courting females in comparison to control males. Within dosed groups, homosexual males showed a similar reduction when compared with dosed heterosexual males. We found an average 35 per cent decrease in fledgling production in high-dose birds over the study duration. These results are of interest because (i) MeHg exposure is experimentally tied to demographically important reproductive deficits, (ii) these effects were found at low, chronic exposure levels commonly experienced by wildlife, and (iii) effects on reproductive behaviour and sexual preference mediated by endocrine disruption represent a novel and probably under-reported mechanism by which contaminants may influence wild populations of birds.

  11. Health-related disparities: influence of environmental factors.

    Science.gov (United States)

    Olden, Kenneth; White, Sandra L

    2005-07-01

    Racial disparities in health cannot be explained solely on the basis of poverty, access to health care, behavior, or environmental factors. Their complex etiology is dependent on interactions between all these factors plus genetics. Scientists have been slow to consider genetics as a risk factor because genetic polymorphisms tend to be more variable within a race than between races. Now that studies are demonstrating the existence of racial differences in allelic frequencies for multiple genes affecting a single biologic mechanism, the present argument for a significant genetic role in contributing to health disparities is gaining support. Individuals vary, often significantly, in their response to environmental agents. This variability provides a high "background noise" when scientists examine human populations to identify environmental links to disease. This variability often masks important environmental contributors to disease risk and is a major impediment to efforts to investigate the causes of diseases.Fortunately, investments in the various genome projects have led to the development of tools and databases that can be used to help identify the genetic variations in environmental response genes that can lead to such wide differences in disease susceptibility. NIEHS developed the environ-mental genome project to catalog these genetic variants (polymorphisms)and to identify the ones that play a major role in human susceptibility to environmental agents. This information is being used in epidemiologic studies to pinpoint environmental contributors to disease better. The research summarized in this article is critically important for tying genetics and the environment to health disparities, and for the development of a rational approach to gauge environmental threats. Common variants in genes play pivotal roles in determining if or when illness or death result from exposure to drugs or environmental xenobiotics. Most common variants exist in all human

  12. Critical role of environmental factors in the pathogenesis of psoriasis.

    Science.gov (United States)

    Zeng, Jinrong; Luo, Shuaihantian; Huang, Yumeng; Lu, Qianjin

    2017-08-01

    Psoriasis is a common cutaneous disease with multifactorial etiology including genetic and non-genetic factors, such as drugs, smoking, drinking, diet, infection and mental stress. Now, the role of the interaction between environmental factors and genetics are considered to be a main factor in the pathogenesis of psoriasis. However, it is a challenge to explore the mechanisms how the environmental factors break the body balance to affect the onset and development of psoriasis. In this article, we review the pathogenesis of psoriasis and summarize numerous clinical data to reveal the association between environmental factors and psoriasis. In addition, we focus on the mechanisms of environmental risk factors impact on psoriasis and provide a series of potential treatments against environmental risk factors. © 2017 Japanese Dermatological Association.

  13. Prenatal exposure to environmental factors and congenital limb defects.

    Science.gov (United States)

    Alexander, Peter G; Clark, Karen L; Tuan, Rocky S

    2016-09-01

    Limb congenital defects afflict approximately 0.6:1000 live births. In addition to genetic factors, prenatal exposure to drugs and environmental toxicants, represents a major contributing factor to limb defects. Examples of well-recognized limb teratogenic agents include thalidomide, warfarin, valproic acid, misoprostol, and phenytoin. While the mechanism by which these agents cause dymorphogenesis is increasingly clear, prediction of the limb teratogenicity of many thousands of as yet uncharacterized environmental factors (pollutants) remains inexact. This is limited by the insufficiencies of currently available models. Specifically, in vivo approaches using guideline animal models have inherently deficient predictive power due to genomic and anatomic differences that complicate mechanistic comparisons. On the other hand, in vitro two-dimensional (2D) cell cultures, while accessible for cellular and molecular experimentation, do not reflect the three-dimensional (3D) morphogenetic events in vivo nor systemic influences. More robust and accessible models based on human cells that accurately replicate specific processes of embryonic limb development are needed to enhance limb teratogenesis prediction and to permit mechanistic analysis of the adverse outcome pathways. Recent advances in elucidating mechanisms of normal development will aid in the development of process-specific 3D cell cultures within specialized bioreactors to support multicellular microtissues or organoid constructs that will lead to increased understanding of cell functions, cell-to-cell signaling, pathway networks, and mechanisms of toxicity. The promise is prompting researchers to look to such 3D microphysiological systems to help sort out complex and often subtle interactions relevant to developmental malformations that would not be evident by standard 2D cell culture testing. Birth Defects Research (Part C) 108:243-273, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  14. Assessing the environmental health relevance of cooling towers--a systematic review of legionellosis outbreaks.

    Science.gov (United States)

    Walser, Sandra M; Gerstner, Doris G; Brenner, Bernhard; Höller, Christiane; Liebl, Bernhard; Herr, Caroline E W

    2014-03-01

    Bioaerosols from cooling towers are often suspected to cause community-acquired legionellosis outbreaks. Although Legionella infections can mostly be assigned to the emission sources, uncertainty exists about the release and distribution into the air, the occurrence of the respirable virulent form and the level of the infective concentration. Our study aimed to evaluate studies on legionellosis outbreaks attributed to cooling towers published within the last 11 years by means of a systematic review of the literature. 19 legionellosis outbreaks were identified affecting 12 countries. Recurring events were observed in Spain and Great Britain. In total, 1609 confirmed cases of legionellosis and a case-fatality rate of approximately 6% were reported. Duration of outbreaks was 65 days on average. For diagnosis the urinary antigen test was mainly used. Age, smoking, male sex and underlying diseases (diabetes, immunodeficiency) could be confirmed as risk factors. Smoking and underlying diseases were the most frequent risk factors associated with legionellosis in 11 and 10 of the 19 studies, respectively. The meteorological conditions varied strongly. Several studies reported a temporal association of outbreaks with inadequate maintenance of the cooling systems. A match of clinical and environmental isolates by serotyping and/or molecular subtyping could be confirmed in 84% of outbreaks. Legionella-contaminated cooling towers as environmental trigger, in particular in the neighbourhood of susceptible individuals, can cause severe health problems and even death. To prevent and control Legionella contamination of cooling towers, maintenance actions should focus on low-emission cleaning procedures of cooling towers combined with control measurements of water and air samples. Procedures allowing rapid detection and risk assessment in the case of outbreaks are essential for adequate public health measures. Systematic registration of cooling towers will facilitate the

  15. Rate constants and mechanisms for the crystallization of Al nano-goethite under environmentally relevant conditions

    Science.gov (United States)

    Bazilevskaya, Ekaterina; Archibald, Douglas D.; Martínez, Carmen Enid

    2012-07-01

    Mobile inorganic and organic nanocolloidal particles originate-from and interact-with bulk solid phases in soil and sediment environments, and as such, they contribute to the dynamic properties of environmental systems. In particular, ferrihydrite and (nano)goethite are the most abundant of nanocolloidal Fe oxy(hydr)oxides in these environments. We therefore investigated the ferrihydrite to goethite phase transformation using experimental reaction conditions that mimicked environmental conditions where the formation of nanocolloidal Fe oxy(hydr)oxides may occur: slow titration of dilute solutions to pH 5 at 25 °C with and without 2 mol% Al. Subsequently, the rate constants from 54-d nano-goethite aging/crystallization experiments at 50 °C were determined using aliquots pulled for vibrational spectroscopy (including multivariate curve resolution, MCR, analyses of infrared spectra) and synchrotron-based X-ray diffraction (XRD). We also present a mechanistic model that accounts for the nano-goethite crystallization observed by the aforementioned techniques, and particle structural characteristics observed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). In contrast to the common assumption that metastable ferrihydrite precipitates first, before it transforms to goethite, the presence of characteristic infrared bands in freshly synthesized nanoparticle suspensions indicate goethite can precipitate directly from solution under environmentally relevant conditions: low Fe concentration, ambient temperature, and pH maintained at 5. However, the presence of 2 mol% Al prevented direct goethite precipitation. Rate constants obtained by fitting the contributions from the MCR-derived goethite-like component to the OH-stretching region were (7.4 ± 1.1) × 10-7 s-1 for 0% Al and (4.2 ± 0.4) × 10-7 s-1 for 2 mol% Al suspensions. Rate constants derived from intensities of OH-bending infrared vibrations (795 and 895 cm-1) showed similar values

  16. Determination of environmental factors affecting dengue incidence ...

    African Journals Online (AJOL)

    . Prevention movement is considered ineffective; therefore, a more efficient early warning system is required. It is required strongly correlated variables to as predictor in early warning system. This study aims to identify the environmental ...

  17. External factors influencing the environmental performance of South African firms

    CSIR Research Space (South Africa)

    Peart, R

    2001-01-01

    Full Text Available This article reviews the external factors that influence environmental performance of companies in South Africa, drawing on international and local literature. After considering factors within the natural, social, economic and institutional...

  18. Relevant Factors in The Post-Merger Systems Integration and Information Technology in Brazilian Banks

    Directory of Open Access Journals (Sweden)

    Marcel Ginotti Pires

    2017-01-01

    Full Text Available This article discusses the factors present in post-merger integration of Systems and Information Technology (SIT that lead to positive and negative results in mergers and acquisitions (M & A. The research comprised three of the largest acquiring banks in Brazil. We adopted two methods of research, qualitative, to operationalize the theoretical concepts and quantitative, to test the hypotheses. We interviewed six executives of banks that held relevant experience in M & A processes. Subsequently, we applied questionnaires to IT professionals who were involved in the SIT integration processes. The results showed that the quality and expertise of the integration teams and managing the integration were the most relevant factors in the processes, with positive results for increased efficiency and the increased capacity of SIT. Negative results were due to failures in exploiting learning opportunities, the loss of employees and the inexpressive record of integration procedures.

  19. Investigation of uranium binding forms in environmentally relevant waters and bio-fluids

    International Nuclear Information System (INIS)

    Osman, Alfatih Ahmed Alamin

    2014-01-01

    Uranium from natural and anthropogenic sources is continuously and increasingly released into the environment, enters the food chain, and eventually accumulates into the bio-systems including humans. Therefore, uranium exposure to human becomes more and more a subject of interest in many scientific disciplines such as environmental medicine, toxicology, and radiation protection. Ingestion of uranium via food and drinking water is one of the important pathways of exposure. The ongoing discussion in Germany and the European Union (EU) on the maximum uranium levels in drinking water reflects the increasing awareness of uranium as a public health problem. For water suppliers in many countries around the world, uranium contamination of drinking water also becomes a salient issue. Nevertheless, the health consequences are dependent not only on the level and duration of exposure, but mainly on the physical and chemical forms of uranium (speciation). Unlike total concentration, speciation can provide more information on uranium behavior (mobility, bioavailability, and toxicity) in both geo-systems and bio-systems. The aim of the current work is to elucidate uranium speciation in natural samples (water, bio-fluids) by both spectroscopic means and theoretical modeling. For this purpose, environmentally relevant waters (mineral water, groundwater, acid drainage waters) and natural human body fluids have been investigated. The cryogenic time-resolved laser-induced fluorescence spectroscopy (cryo-TRLFS) at 153 K has successfully been used to identify the speciation in such complex matrices of high organic content and low uranium concentrations without any prior treatment. Data about uranium binding forms in natural waters could be used for more insight research on uranium chemo-toxicity in drinking water since there is no available information on the long-term exposure of low uranium concentrations via ingestion on humans. Altogether the obtained data provides a comprehensive

  20. Investigation of uranium binding forms in environmentally relevant waters and bio-fluids

    Energy Technology Data Exchange (ETDEWEB)

    Osman, Alfatih Ahmed Alamin

    2014-06-04

    Uranium from natural and anthropogenic sources is continuously and increasingly released into the environment, enters the food chain, and eventually accumulates into the bio-systems including humans. Therefore, uranium exposure to human becomes more and more a subject of interest in many scientific disciplines such as environmental medicine, toxicology, and radiation protection. Ingestion of uranium via food and drinking water is one of the important pathways of exposure. The ongoing discussion in Germany and the European Union (EU) on the maximum uranium levels in drinking water reflects the increasing awareness of uranium as a public health problem. For water suppliers in many countries around the world, uranium contamination of drinking water also becomes a salient issue. Nevertheless, the health consequences are dependent not only on the level and duration of exposure, but mainly on the physical and chemical forms of uranium (speciation). Unlike total concentration, speciation can provide more information on uranium behavior (mobility, bioavailability, and toxicity) in both geo-systems and bio-systems. The aim of the current work is to elucidate uranium speciation in natural samples (water, bio-fluids) by both spectroscopic means and theoretical modeling. For this purpose, environmentally relevant waters (mineral water, groundwater, acid drainage waters) and natural human body fluids have been investigated. The cryogenic time-resolved laser-induced fluorescence spectroscopy (cryo-TRLFS) at 153 K has successfully been used to identify the speciation in such complex matrices of high organic content and low uranium concentrations without any prior treatment. Data about uranium binding forms in natural waters could be used for more insight research on uranium chemo-toxicity in drinking water since there is no available information on the long-term exposure of low uranium concentrations via ingestion on humans. Altogether the obtained data provides a comprehensive

  1. On the form factors of relevant operators and their cluster property

    International Nuclear Information System (INIS)

    Acerbi, C.; Valleriani, A.; Mussardo, G.

    1996-09-01

    We compute the Form Factors of the relevant scaling operators in a class of integrable models without internal symmetries by exploiting their cluster properties. Their identification is established by computing the corresponding anomalous dimensions by means of Delfino-Simonetti-Cardy sum-rule and further confirmed by comparing some universal ratios of the nearby non-integrable quantum field theories with their independent numerical determination. (author). 21 refs, 5 figs, 16 tabs

  2. Relevant factors for tacit knowledge transfer within organizations: an exploratory study

    OpenAIRE

    Lemos,Bernardo; Joia,Luiz Antonio

    2012-01-01

    Knowledge and management of such knowledge have been studied for some time now in the field of Management. However, in the 1990s, with the growth in the economy based on intangible assets, companies needed more than an unstructured approach to corporate knowledge management to succeed in this new competitive environment. Therefore, this article aims to identify, in an exploratory way, the relevant factors for tacit knowledge transfer within a major Brazilian oil company trough a case study. T...

  3. Ru(III) catalyzed permanganate oxidation of aniline at environmentally relevant pH.

    Science.gov (United States)

    Zhang, Jing; Zhang, Ying; Wang, Hui; Guan, Xiaohong

    2014-07-01

    Ru(III) was employed as catalyst for aniline oxidation by permanganate at environmentally relevant pH for the first time. Ru(III) could significantly improve the oxidation rate of aniline by 5-24 times with its concentration increasing from 2.5 to 15 μmol/L. The reaction of Ru(III) catalyzed permanganate oxidation of aniline was first-order with respect to aniline, permanganate and Ru(III), respectively. Thus the oxidation kinetics can be described by a third-order rate law. Aniline degradation by Ru(III) catalyzed permanganate oxidation was markedly influenced by pH, and the second-order rate constant (ktapp) decreased from 643.20 to 2.67 (mol/L)⁻¹sec⁻¹ with increasing pH from 4.0 to 9.0, which was possibly due to the decrease of permanganate oxidation potential with increasing pH. In both the uncatalytic and catalytic permanganate oxidation, six byproducts of aniline were identified in UPLC-MS/MS analysis. Ru(III), as an electron shuttle, was oxidized by permanganate to Ru(VI) and Ru(VII), which acted the co-oxidants for decomposition of aniline. Although Ru(III) could catalyze permanganate oxidation of aniline effectively, dosing homogeneous Ru(III) into water would lead to a second pollution. Therefore, efforts would be made to investigate the catalytic performance of supported Ru(III) toward permanganate oxidation in our future study. Copyright © 2014. Published by Elsevier B.V.

  4. Environmentally relevant exposure to 17{alpha}-ethinylestradiol affects the telencephalic proteome of male fathead minnows

    Energy Technology Data Exchange (ETDEWEB)

    Martyniuk, Christopher J., E-mail: cmartyn@unb.ca [Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL, 32611 (United States); Kroll, Kevin J.; Doperalski, Nicholas J.; Barber, David S.; Denslow, Nancy D. [Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL, 32611 (United States)

    2010-07-15

    Estrogens are key mediators of neuronal processes in vertebrates. As such, xenoestrogens present in the environment have the potential to alter normal central nervous system (CNS) function. The objectives of the present study were (1) to identify proteins with altered abundance in the male fathead minnow telencephalon as a result of low-level exposure to17{alpha}-ethinylestradiol (EE{sub 2}), and (2) to better understand the underlying mechanisms of 17{beta}-estradiol (E{sub 2}) feedback in this important neuroendocrine tissue. Male fathead minnows exposed to a measured concentration of 5.4 ng EE{sub 2}/L for 48 h showed decreased plasma E{sub 2} levels of approximately 2-fold. Of 77 proteins that were quantified statistically, 14 proteins were down-regulated after EE{sub 2} exposure, including four histone proteins, ATP synthase, H+ transporting subunits, and metabolic proteins (lactate dehydrogenase B4, malate dehydrogenase 1b). Twelve proteins were significantly induced by EE{sub 2} including microtubule-associated protein tau (Mapt), astrocytic phosphoprotein, ependymin precursor, and calmodulin. Mapt showed an increase in protein abundance but a decrease in mRNA expression after EE{sub 2} exposure{sub ,} suggesting there may be a negative feedback response in the telencephalon to decreased mRNA transcription with increasing Mapt protein abundance. These results demonstrate that a low, environmentally relevant exposure to EE{sub 2} can rapidly alter the abundance of proteins involved in cell differentiation and proliferation, neuron network morphology, and long-term synaptic potentiation. Together, these findings provide a better understanding of the molecular responses underlying E{sub 2} feedback in the brain and demonstrate that quantitative proteomics can be successfully used in ecotoxicology to characterize affected cellular pathways and endocrine physiology.

  5. An environmentally relevant endocrine-disrupting antiandrogen, vinclozolin, affects calling behavior of male Xenopus laevis.

    Science.gov (United States)

    Hoffmann, Frauke; Kloas, Werner

    2010-09-01

    Vinclozolin (VIN) is an antiandrogenic model substance as well as a common fungicide that can affect the endocrine system of vertebrates. The objective of this study was to investigate how VIN affects mate calling behavior of South African clawed frogs (Xenopus laevis) and whether it is effective at environmentally relevant concentrations. Male X. laevis were injected with human chorionic gonadotropin (hCG) to stimulate their androgen-controlled mate calling behavior and were treated with VIN at concentrations of 10(-6), 10(-8) and 10(-10)M. VIN at 10(-6)M reduced calling activity. Furthermore, the vocalization composition of VIN-treated X. laevis was altered. The call types advertisement calls and chirping are uttered by reproductively active males, whereas the call types growling, ticking, and rasping indicate a sexually unaroused state of a male. VIN at any of the tested concentrations led to a decrease in utterance of calls, which indicate a sexually aroused state of the males, and an increase in relative proportions of calls, indicating a sexually unaroused state of the males. Additionally, the mean duration of clicks and the number of accentuated clicks during the advertisement calls decreased at all concentrations of VIN. No significant differences were observed in any other temporal or spectral calling parameters between the treatments. This study illustrates that exposure to the antiandrogen VIN might result in a reduced reproductive success by altering mate calling behavior of X. laevis. Moreover, it suggests that the behavioral parameters examined in this study can be used as sensitive biomarkers for detecting antiandrogenic endocrine disrupting compounds in amphibians. Copyright (c) 2010 Elsevier Inc. All rights reserved.

  6. Role of environmental factors in the timing of puberty

    DEFF Research Database (Denmark)

    Euling, S.Y.; Selevan, S.G.; Pescovitz, O.H.

    2008-01-01

    Puberty-timing measures have historically been used as indicators of adequate nutrition and growth. More recently, these measures have been examined in relation to exposure to estrogenic or antiandrogenic agents, as well as other environmental factors. The scientific community has debated whether...... puberty timing is occurring earlier today than in the mid-1900s in the United States and, if so, whether environmental factors play a role; however, no one has asked a multidisciplinary panel to resolve this question. Thus, a multidisciplinary expert panel jointly sponsored by the US Environmental...... Protection Agency, the National Institute of Environmental Health Sciences, and Serono Symposia International was convened to examine the evidence of a secular trend, identify potential environmental factors of concern, and identify research needs regarding environmental factors and puberty timing at "The...

  7. Systematic assessment of environmental risk factors for bipolar disorder

    DEFF Research Database (Denmark)

    Bortolato, Beatrice; Köhler, Cristiano A.; Evangelou, Evangelos

    2017-01-01

    factors supported by high epidemiological credibility. Methods: We searched the Pubmed/MEDLINE, EMBASE and PsycInfo databases up to 7 October 2016 to identify systematic reviews and meta-analyses of observational studies that assessed associations between putative environmental risk factors and BD......Objectives: The pathophysiology of bipolar disorder is likely to involve both genetic and environmental risk factors. In our study, we aimed to perform a systematic search of environmental risk factors for BD. In addition, we assessed possible hints of bias in this literature, and identified risk...... met the inclusion criteria (seven meta-analyses and nine qualitative systematic reviews). Fifty-one unique environmental risk factors for BD were evaluated. Six meta-analyses investigated associations with a risk factor for BD. Only irritable bowel syndrome (IBS) emerged as a risk factor for BD...

  8. A review on environmental factors regulating arsenic methylation in humans

    International Nuclear Information System (INIS)

    Tseng, C.-H.

    2009-01-01

    Subjects exposed to arsenic show significant inter-individual variation in urinary patterns of arsenic metabolites but insignificant day-to-day intra-individual variation. The inter-individual variation in arsenic methylation can be partly responsible for the variation in susceptibility to arsenic toxicity. Wide inter-ethnic variation and family correlation in urinary arsenic profile suggest a genetic effect on arsenic metabolism. In this paper the environmental factors affecting arsenic metabolism are reviewed. Methylation capacity might reduce with increasing dosage of arsenic exposure. Furthermore, women, especially at pregnancy, have better methylation capacity than their men counterparts, probably due to the effect of estrogen. Children might have better methylation capacity than adults and age shows inconsistent relevance in adults. Smoking and alcohol consumption might be associated with a poorer methylation capacity. Nutritional status is important in the methylation capacity and folate may facilitate the methylation and excretion of arsenic. Besides, general health conditions and medications might influence the arsenic methylation capacity; and technical problems can cause biased estimates. The consumption of seafood, seaweed, rice and other food with high arsenic contents and the extent of cooking and arsenic-containing water used in food preparation may also interfere with the presentation of the urinary arsenic profile. Future studies are necessary to clarify the effects of the various arsenic metabolites including the trivalent methylated forms on the development of arsenic-induced human diseases with the consideration of the effects of confounding factors and the interactions with other effect modifiers

  9. Environmental Performance in Countries Worldwide: Determinant Factors and Multivariate Analysis

    Directory of Open Access Journals (Sweden)

    Isabel Gallego-Alvarez

    2014-11-01

    Full Text Available The aim of this study is to analyze the environmental performance of countries and the variables that can influence it. At the same time, we performed a multivariate analysis using the HJ-biplot, an exploratory method that looks for hidden patterns in the data, obtained from the usual singular value decomposition (SVD of the data matrix, to contextualize the countries grouped by geographical areas and the variables relating to environmental indicators included in the environmental performance index. The sample used comprises 149 countries of different geographic areas. The findings obtained from the empirical analysis emphasize that socioeconomic factors, such as economic wealth and education, as well as institutional factors represented by the style of public administration, in particular control of corruption, are determinant factors of environmental performance in the countries analyzed. In contrast, no effect on environmental performance was found for factors relating to the internal characteristics of a country or political factors.

  10. Unscrambling cyanobacteria community dynamics related to environmental factors

    Directory of Open Access Journals (Sweden)

    Mireia eBertos-Fortis

    2016-05-01

    Full Text Available Future climate scenarios in the Baltic Sea project an increase of cyanobacterial bloom frequency and duration, attributed to eutrophication and climate change. Some cyanobacteria can be toxic and their impact on ecosystem services is relevant for a sustainable sea. Yet, there is limited understanding of the mechanisms regulating cyanobacterial diversity and biogeography. Here we unravel successional patterns and changes in cyanobacterial community structure using a two-year monthly time-series during the productive season in a 100 km coastal-offshore transect using microscopy and high-throughput sequencing of 16S rRNA gene fragments. A total of 565 cyanobacterial OTUs were found, of which 231 where filamentous/colonial and 334 picocyanobacterial. Spatial differences in community structure between coastal and offshore waters were minor. An epidemic population structure (dominance of a single cluster was found for Aphanizomenon/Dolichospermum within the filamentous/colonial cyanobacterial community. In summer, this cluster simultaneously occurred with opportunistic clusters/OTUs e.g. Nodularia spumigena and Pseudanabaena. Picocyanobacteria, Synechococcus/Cyanobium, formed a consistent but highly diverse group. Overall, the potential drivers structuring summer cyanobacterial communities were temperature and salinity. However, the different responses to environmental factors among and within genera suggest high niche specificity for individual OTUs. The recruitment and occurrence of potentially toxic filamentous/colonial clusters was likely related to disturbance such as mixing events and short-term shifts in salinity, and not solely dependent on increasing temperature and nitrogen-limiting conditions. Nutrients did not explain further the changes in cyanobacterial community composition. Novel occurrence patterns were identified as a strong seasonal succession revealing a tight coupling between the emergence of opportunistic picocyanobacteria and

  11. Free and Open Source GIS Tools: Role and Relevance in the Environmental Assessment Community

    Science.gov (United States)

    The presence of an explicit geographical context in most environmental decisions can complicate assessment and selection of management options. These decisions typically involve numerous data sources, complex environmental and ecological processes and their associated models, ris...

  12. Radioactive waste facility as environmental preservation factor

    International Nuclear Information System (INIS)

    Heilbron Filho, P.F.L.; Xavier, Ana Maria

    1997-01-01

    The objective of this article is to show, in a resumed way, the many aspects involved in the selection, licensing and construction of a repository for the safe disposal of low and intermediate radioactive level wastes in Brazil where from we conclude that a repository is for sure an agent of environmental preservation. (author)

  13. The relevance and impact of Ethical Consciousness on Environmental Management in Zambia: A philosophical critique

    International Nuclear Information System (INIS)

    Mweshi, John

    2004-01-01

    This dissertation is informed by the need for adequate ethical consciousness in view of the perceived need for public responsibility, cooperation and participation in ensuring sound environmental management. It investigates and critiques the extent to which an adequate range of ethical principles has been incorporated in Zambia's attempts to address environmental issues.The investigation focused on the role of government policy, education system and the mass media in promoting responsible environmental management and practices by raising environmental ethical consciousness. The study confirmed the preponderance of economic utilitarianism with regard to environmental issues. (author)

  14. Regulatory standards applicable or relevant to the independent Hanford environmental surveillance and oversight program

    International Nuclear Information System (INIS)

    King, S.E.; Hendrickson, P.L.; Siegel, M.R.; Woodruff, M.G.; Belfiglio, J.; Elliott, R.W.

    1990-03-01

    The authors reviewed federal and state statutes and regulations, as well as Department of Energy (DOE) orders and other guidance material, for potential applicability to the environmental surveillance program conducted for the Hanford site by the Pacific Northwest Laboratory (PNL). There are no federal or state statutes or regulations which are directly applicable to the environmental surveillance program. However, other regulatory schemes, while not directly applicable to the environmental surveillance program, are important insofar as they are indicative of regulatory concern and direction. Because of the evolving nature of environmental regulations, this area needs to be closely monitored for future impact on environmental surveillance activities. 9 refs.,

  15. Critical factors in environmental impact assessment

    International Nuclear Information System (INIS)

    Creasey, R.

    1999-01-01

    Environmental impact assessment (EIA) has shown that it is of proven benefit to the overall planning and environmental management of resource development projects, but certain elements within the application and practice of EIA remain problematic for proponents and regulatory decision makers alike. The use of the word 'critical' in the title of this paper suggests that if the components identified are not considered or implemented properly through the process of EIA, the product will be of less value to both the proponent and decision maker. In the context of EIA, the regulatory, financial, legal and social benefits that accrue make the need for good EIA practice even more imperative. A discussion is included that highlights a number of issues that need to be addressed to improve the effectiveness of EIA, a tool necessary to attaining provincial and federal regulatory approvals. To a large extent, the discussion reflects items of contemporary public concern, and those emerging issues of the scientific and regulatory community. At the same time, it needs to be realized that not all the identified items are necessarily new to the practice of impact assessment, but are nonetheless important to professional environmental impact assessment and decision making. Insight is also provided into the direction of decision making of the Energy and Utilities Board as it will affect the regulatory review and administration of resource development projects in the province of Alberta. 16 refs

  16. Mycobacterium biofilms: factors involved in development, dispersal, and therapeutic strategies against biofilm-relevant pathogens.

    Science.gov (United States)

    Xiang, Xiaohong; Deng, Wanyan; Liu, Minqiang; Xie, Jianping

    2014-01-01

    Many bacteria can develop biofilm (BF), a multicellular structure largely combining bacteria and their extracellular polymeric substances (EPS). The formation of biofilm results in an alternative existence in which microbes ensure their survival in adverse environments. Biofilm-relevant infections are more persistent, resistant to most antibiotics, and more recalcitrant to host immunity. Mycobacterium tuberculosis, the causative agent of tuberculosis, can develop biofilm, though whether M. tuberculosis can form biofilm within tuberculosis patients has yet to be determined. Here, we summarize the factors involved in the development and dispersal of mycobacterial biofilms, as well as underlying regulatory factors and inhibitors against biofilm to deepen our understanding of their development and to elucidate potential novel modes of action for future antibiotics. Key factors in biofilm formation identified as drug targets represent a novel and promising avenue for developing better antibiotics.

  17. [Relevant factors of early puberty timing in urban primary schools in Chongqing].

    Science.gov (United States)

    Luo, Yan; Liu, Qin; Wen, Yi; Liu, Shudan; Lei, Xun; Wang, Hong

    2016-05-01

    To investigate the status of puberty timing and relevant factors of early puberty timing in children from grade one to four in urban primary schools of Chongqing. According to the purposive sample method, four urban primary schools in Chongqing were selected and of which 1471 children from grade one to four who have obtained informed consent were recruited. Questionnaire survey on social-demographic characteristics and family environment (e.g., age, parents' relationship, diet and lifestyle, etc), and Pubertal Development Scale (PDS) survey and physical examination (measurements of height, weight, pubertal development status, etc) were conducted. P25, P50, P75 ages of each important pubertal event were calculated by probit regression. Univariate and multivariate analysis were used to analyze relevant factors. The detection rate of early puberty timing was 17.7%, and the median ages of the onset of breast and testicular development were 10.77 and 11.48 years old, respectively. Multivariate logistic regression showed that early puberty timing occurred more likely in girls than in boys (OR = 0.561, 95% CI 0.406-0.774), and bad relationship between parents (OR = 1.320, 95% CI 1.007-1.729) and hair-products-use (OR = 1.685, 95%, CI 1.028-2.762) were risk factors of early puberty timing. Early onset of puberty in urban Chongqing is still exist. Gender, parents' relationship, and hair-products-use have an essential impact on early puberty timing.

  18. Review of the impact of environmental factors on human performance

    International Nuclear Information System (INIS)

    Echeverria, D.; Barnes, V.; Bittner, A.

    1990-01-01

    The purpose of this project is to determine the effects of various environmental factors such as vibration, noise, heat, cold, and illumination on task performance in U.S. nuclear power plants. Although the effects of another environmental factor, radiation, is of concern to licensees and the Nuclear Regulatory Commission (NRC), much less attention has been paid to the potential effects of these other environmental factors. Performance effects from these environmental factors have been observed in other industries; for example, vibration can impair vision and noise can cause short- or long-term hearing loss. A primary goal of this project is to provide the technical basis for determining the likelihood of these factors affecting task performance in nuclear power plants, and thus the safety of the public

  19. Effectiveness and relevant factors of 2% rebamipide ophthalmic suspension treatment in dry eye.

    Science.gov (United States)

    Ueda, Kaori; Matsumiya, Wataru; Otsuka, Keiko; Maeda, Yoshifumi; Nagai, Takayuki; Nakamura, Makoto

    2015-06-06

    Rebamipide with mucin secretagogue activity was recently approved for the treatment of dry eye. The efficacy and safety in the treatment of rebamipide were shown in two pivotal clinical trials. It was the aim of this study to evaluate the effect of 2% rebamipide ophthalmic suspension in patients with dry eye and analyze relevant factors for favorable effects of rebamipide in clinical practice. This was a retrospective cohort study of 48 eyes from 24 patients with dry eye treated with 2% rebamipide ophthalmic suspension. Dry eye-related symptom score, tear film break-up time (TBUT), fluorescein ocular surface staining score (FOS) and the Schirmer test were used to collect the data from patients at baseline, and at 2, 4, 8, and 12 week visits. To determine the relevant factors, multiple regression analyses were then performed. Mean dry eye-related symptom score showed a significant improvement from the baseline (14.5 points) at 2, 4, 8 and 12 weeks (9.80, 7.04, 7.04 and 7.83 points, corrected P value treatment. For ocular symptoms, three parameters (foreign body sensation, dry eye sensation and ocular discomfort) showed significant improvements at all visits. The multiple regression analyses showed that the fluorescein conjunctiva staining score was significantly correlated with the changes of dry eye-related symptom score at 12 weeks (P value = 0.017) and dry eye-related symptom score was significantly correlated with independent variables for the changes of FOS at 12 weeks (P value = 0.0097). Two percent rebamipide ophthalmic suspension was an effective therapy for dry eye patients. Moreover the fluorescein conjunctiva staining score and dry eye-related symptom score might be good relevant factors for favorable effects of rebamipide.

  20. Psychosocial and Environmental Factors Associated with Dog

    OpenAIRE

    Richards, Elizabeth; McDonough, Megan H; Edwards, Nancy E; Lyle, RM; Troped, Philip J

    2013-01-01

    Dog walking is associated with higher levels of physical activity (PA). However, not all dog owners walk their dog(s) at a level sufficient for health benefits. Therefore, identifying correlates of dog walking may help to inform the design of more effective interventions to promote this specific form of PA. The purpose of this study was to examine psychosocial and environmental correlates of dog walking and relationships of dog walking with overall PA. In 2010, 391 dog owners (Mage= 43.6±12.3...

  1. Biological effects of environmentally relevant concentrations of the pharmaceutical Triclosan in the marine mussel Perna perna (Linnaeus, 1758)

    Energy Technology Data Exchange (ETDEWEB)

    Sanzi Cortez, Fernando, E-mail: lecotox@unisanta.br [Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, 05508-000 Sao Paulo, SP (Brazil); Laboratorio de Ecotoxicologia, Universidade Santa Cecilia, 11045-907 Santos, SP (Brazil); Dias Seabra Pereira, Camilo [Laboratorio de Ecotoxicologia, Universidade Santa Cecilia, 11045-907 Santos, SP (Brazil); Instituto do Mar, Universidade Federal de Sao Paulo, 11030-400 Santos, SP (Brazil); Ramos Santos, Aldo Ramos [Laboratorio de Ecotoxicologia, Universidade Santa Cecilia, 11045-907 Santos, SP (Brazil); Cesar, Augusto; Choueri, Rodrigo Brasil [Laboratorio de Ecotoxicologia, Universidade Santa Cecilia, 11045-907 Santos, SP (Brazil); Instituto do Mar, Universidade Federal de Sao Paulo, 11030-400 Santos, SP (Brazil); Martini, Gisela de Assis [Laboratorio de Ecotoxicologia, Universidade Santa Cecilia, 11045-907 Santos, SP (Brazil); Bohrer-Morel, Maria Beatriz [Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, 05508-000 Sao Paulo, SP (Brazil)

    2012-09-15

    Triclosan (5-Chloro-2-(2,4-dichlorophenoxy) phenol) is an antibacterial compound widely employed in pharmaceuticals and personal care products. Although this emerging compound has been detected in aquatic environments, scarce information is found on the effects of Triclosan to marine organisms. The aim of this study was to evaluate the toxicity of a concentration range of Triclosan through fertilization assay (reproductive success), embryo-larval development assay (early life stage) and physiological stress (Neutral Red Retention Time assay - NRRT) (adult stage) in the marine sentinel organism Perna perna. The mean inhibition concentrations for fertilization (IC{sub 50} = 0.490 mg L{sup -1}) and embryo-larval development (IC{sub 50} = 0.135 mg L{sup -1}) tests were above environmental relevant concentrations (ng L{sup -1}) given by previous studies. Differently, significant reduction on NRRT results was found at 12 ng L{sup -1}, demonstrating the current risk of the continuous introduction of Triclosan into aquatic environments, and the need of ecotoxicological studies oriented by the mechanism of action of the compound. - Highlights: Black-Right-Pointing-Pointer Triclosan causes biological adverse effects at environmental relevant concentrations. Black-Right-Pointing-Pointer Mechanisms of action oriented assays were more sensitive to detect biological damages. Black-Right-Pointing-Pointer Currently there is environmental risks concerned Triclosan in aquatic ecosystems. - Triclosan causes biological adverse effects at environmentally relevant concentrations.

  2. Biological effects of environmentally relevant concentrations of the pharmaceutical Triclosan in the marine mussel Perna perna (Linnaeus, 1758)

    International Nuclear Information System (INIS)

    Sanzi Cortez, Fernando; Dias Seabra Pereira, Camilo; Ramos Santos, Aldo Ramos; Cesar, Augusto; Choueri, Rodrigo Brasil; Martini, Gisela de Assis; Bohrer-Morel, Maria Beatriz

    2012-01-01

    Triclosan (5-Chloro-2-(2,4-dichlorophenoxy) phenol) is an antibacterial compound widely employed in pharmaceuticals and personal care products. Although this emerging compound has been detected in aquatic environments, scarce information is found on the effects of Triclosan to marine organisms. The aim of this study was to evaluate the toxicity of a concentration range of Triclosan through fertilization assay (reproductive success), embryo-larval development assay (early life stage) and physiological stress (Neutral Red Retention Time assay - NRRT) (adult stage) in the marine sentinel organism Perna perna. The mean inhibition concentrations for fertilization (IC 50 = 0.490 mg L −1 ) and embryo-larval development (IC 50 = 0.135 mg L −1 ) tests were above environmental relevant concentrations (ng L −1 ) given by previous studies. Differently, significant reduction on NRRT results was found at 12 ng L −1 , demonstrating the current risk of the continuous introduction of Triclosan into aquatic environments, and the need of ecotoxicological studies oriented by the mechanism of action of the compound. - Highlights: ► Triclosan causes biological adverse effects at environmental relevant concentrations. ► Mechanisms of action oriented assays were more sensitive to detect biological damages. ► Currently there is environmental risks concerned Triclosan in aquatic ecosystems. - Triclosan causes biological adverse effects at environmentally relevant concentrations.

  3. Nanoparticle dispersion in environmentally relevant culture media: a TiO2 case study and considerations for a general approach

    International Nuclear Information System (INIS)

    Horst, Allison M.; Ji, Zhaoxia; Holden, Patricia A.

    2012-01-01

    Nanoparticle exposure in toxicity studies requires that nanoparticles are bioavailable by remaining highly dispersed in culture media. However, reported dispersion approaches are variable, mostly study-specific, and not transferable owing to their empirical basis. Furthermore, many published approaches employ proteinaceous dispersants in rich laboratory media, both of which represent end members in environmental scenarios. Here, a systematic approach was developed to disperse initially agglomerated TiO 2 nanoparticles (Aeroxide® TiO 2 P25, Evonik, NJ; primary particle size range 6.4–73.8 nm) in oligotrophic culture medium for environmentally relevant bacterial toxicity studies. Based on understanding particle–particle interactions in aqueous media and maintaining environmental relevance, the approach involves (1) quantifying the relationship between pH and zeta potential to determine the point of zero charge of select nanoparticles in water; (2) nominating, then testing and selecting, environmentally relevant stabilizing agents; and (3) dispersing via “condition and capture” whereby stock dry powder nanoparticles are sonicated in pre-conditioned (with base, or acid, plus stabilizing agent) water, then diluted into culture media. The “condition and capture” principle is transferable to other nanoparticle and media chemistries: simultaneously, mechanically and electrostatically, nanoparticles can be dispersed with surrounding stabilizers that coat and sterically hinder reagglomeration in the culture medium.

  4. Quantifying environmental limiting factors on tree cover using geospatial data.

    Science.gov (United States)

    Greenberg, Jonathan A; Santos, Maria J; Dobrowski, Solomon Z; Vanderbilt, Vern C; Ustin, Susan L

    2015-01-01

    Environmental limiting factors (ELFs) are the thresholds that determine the maximum or minimum biological response for a given suite of environmental conditions. We asked the following questions: 1) Can we detect ELFs on percent tree cover across the eastern slopes of the Lake Tahoe Basin, NV? 2) How are the ELFs distributed spatially? 3) To what extent are unmeasured environmental factors limiting tree cover? ELFs are difficult to quantify as they require significant sample sizes. We addressed this by using geospatial data over a relatively large spatial extent, where the wall-to-wall sampling ensures the inclusion of rare data points which define the minimum or maximum response to environmental factors. We tested mean temperature, minimum temperature, potential evapotranspiration (PET) and PET minus precipitation (PET-P) as potential limiting factors on percent tree cover. We found that the study area showed system-wide limitations on tree cover, and each of the factors showed evidence of being limiting on tree cover. However, only 1.2% of the total area appeared to be limited by the four (4) environmental factors, suggesting other unmeasured factors are limiting much of the tree cover in the study area. Where sites were near their theoretical maximum, non-forest sites (tree cover demand, and closed-canopy forests were not limited by any particular environmental factor. The detection of ELFs is necessary in order to fully understand the width of limitations that species experience within their geographic range.

  5. An analysis of contingent factors for the detection of strategic relevance in business information technologies

    Directory of Open Access Journals (Sweden)

    Antonio Paños Álvarez

    2005-01-01

    Full Text Available Information Technologies are resources able to create competitive advantages for companies. In this analysis, the Resource-based perspective have taken special relevance, because it is argued that this advantages should be identified, reached and maintained. This work is positioned in the analysis of several contingent factors in the process of pointing the possible assesment of these advantages. It is aproaching a portfolio for helping to select what Information Technologies are valuable for what companies and in what activity areas and the study of in what way the sector, the technological innovation profile, the size and the financial capacity of the companies affects this process

  6. Exploratory Factor Analysis of SCL90-R Symptoms Relevant to Psychosis

    Directory of Open Access Journals (Sweden)

    Javad Amini

    2011-10-01

    Full Text Available "nObjective: Inconsistent results have been reported regarding the symptom dimensions relevant to psychosis in symptoms check list revised (SCL90-R, i.e., "psychoticism" and "paranoid ideation". Therefore, some studies have suggested different factor structures for questions of these two dimensions, and proposed two newly defined dimensions of "schizotypal signs" and "schizophrenia nuclear symptoms". We conducted an exploratory factor analysis on the items of these two dimensions in a general population sample in Iran. "nMethod: A total of 2158 subjects residing in Southern Tehran (capital of Iran were interviewed using the psychoticism and paranoid ideation questions in SCL90-R to assess severity of these symptom dimensions. Factor analysis was done through SAS 9.1.3 PROC FACTOR using Promax rotation (power=3 on the matrix of "polychoric correlations among variables" as the input data. "nResults: Two factors were retained by the proportion criterion. Considering loadings >= 0.5 as minimum criteria for factor loadings, 7 out of 10 questions  from psychoticism ,and 3 out of 6 questions from paranoid ideation were retained, and others were eliminated. The factor labels proposed by the questionnaire suited the extracted factors and were retained. Internal consistency for each of the dimensions was acceptable (Cronbach's alpha 0.7 and 0.74 for paranoid ideation and psychoticism respectively. Composite scores showed a half-normal distribution for both dimensions which is predictable for instruments that detect psychotic symptoms. "nConclusion: Results were in contrast with similar studies, and questioned them by suggesting a different factor structure obtained from a statistically large population. The population in a developing nation (Iran in this study and the socio-cultural differences in developed settings are the potential sources for discrepancies between this analysis and previous reports.

  7. Environmental factors along the Northern Sea Route

    International Nuclear Information System (INIS)

    Fjeld, P.E.

    1993-01-01

    The Northern Sea Route runs ca 5,600 nautical miles across the top of Russia from Murmansk to Vladivostok, and includes half of the Arctic basin. An environmental impact assessment is needed for this route because of the potential for commercial shipping to disturb the vulnerable Arctic environment along the route. For example, Russian development of oil and gas resources in the area served by the route is expected to rise dramatically in the near future. Drilling in the route area offshore has already begun, and potential blowouts or tanker spills are of concern. A pilot study on the environment along this route was conducted in 1990/91, focusing on a study of the literature and communications with Russian scientists working on Arctic ecology. Existing data seem to be insufficient and generally only cover the westernmost and easternmost parts of the route. A five-year research plan is proposed to provide an inventory of Arctic species in the route area and levels of contaminants present, to assess the environmental sensitivity of the area, and analyze impacts that increased shipping might have on the environment. Protection measures will also be suggested. 1 fig

  8. What does policy-relevant global environmental knowledge do? The cases of climate and biodiversity

    NARCIS (Netherlands)

    Turnhout, E.; Dewulf, A.R.P.J.; Hulme, M.

    2016-01-01

    There is a surge in global knowledge-making efforts to inform environmental governance. This article synthesises the current state of the art of social science scholarship about the generation and use of global environmental knowledge. We focus specifically on the issues of scale — providing

  9. Upper GI endoscopy in elderly patients: predictive factors of relevant endoscopic findings.

    Science.gov (United States)

    Buri, Luigi; Zullo, Angelo; Hassan, Cesare; Bersani, Gianluca; Anti, Marcello; Bianco, Maria A; Cipolletta, Livio; Giulio, Emilio Di; Matteo, Giovanni Di; Familiari, Luigi; Ficano, Leonardo; Loriga, Piero; Morini, Sergio; Pietropaolo, Vincenzo; Zambelli, Alessandro; Grossi, Enzo; Tessari, Francesco; Intraligi, Marco; Buscema, Massimo

    2013-03-01

    Elderly patients are at increased risk for peptic ulcer and cancer. Predictive factors of relevant endoscopic findings at upper endoscopy in the elderly are unknown. This was a post hoc analysis of a nationwide, endoscopic study. A total of 3,147 elderly patients were selected. Demographic, clinical, and endoscopic data were systematically collected. Relevant findings and new diagnoses of peptic ulcer and malignancy were computed. Both univariate and multivariate analyses were performed. A total of 1,559 (49.5%), 213 (6.8%), 93 (3%) relevant findings, peptic ulcers, and malignancies were detected. Peptic ulcers and malignancies were more frequent in >85-year-old patients (OR 3.1, 95% CI = 2.0-4.7, p = 0.001). The presence of dysphagia (OR = 5.15), weight loss (OR = 4.77), persistent vomiting (OR = 3.68), anaemia (OR = 1.83), and male gender (OR = 1.9) were significantly associated with a malignancy, whilst overt bleeding (OR = 6.66), NSAIDs use (OR = 2.23), and epigastric pain (OR = 1.90) were associated with the presence of peptic ulcer. Peptic ulcer or malignancies were detected in 10% of elderly patients, supporting the use of endoscopy in this age group. Very elderly patients appear to be at higher risk of such lesions.

  10. An investigation of virulence factors of Legionella pneumophila environmental isolates

    Directory of Open Access Journals (Sweden)

    Elif Özlem Arslan-Aydoğdu

    Full Text Available ABSTRACT Nine Legionella pneumophila strains isolated from cooling towers and a standard strain (L. pneumophila serogroup 1, ATCC 33152, Philadelphia 1 were analyzed and compared in terms of motility, flagella structure, ability to form biofilms, enzymatic activities (hemolysin, nucleases, protease, phospholipase A, phospholipase C, acid phosphatase, alkaline phosphatase and lipase, hemagglutination capabilities, and pathogenicity in various host cells (Acanthamoeba castellanii ATCC 30234, mouse peritoneal macrophages and human peripheral monocytes. All the isolates of bacteria appeared to be motile and polar-flagellated and possessed the type-IV fimbria. Upon the evaluation of virulence factors, isolate 4 was found to be the most pathogenic strain, while 6 out of the 9 isolates (the isolates 1, 2, 3, 4, 5, and 7 were more virulent than the ATCC 33152 strain. The different bacterial strains exhibited differences in properties such as adhesion, penetration and reproduction in the hosts, and preferred host type. To our knowledge, this is the first study to compare the virulence of environmental L. pneumophila strains isolated in Turkey, and it provides important information relevant for understanding the epidemiology of L. pneumophila.

  11. A study of environmental polluting factors by neutron activation method

    International Nuclear Information System (INIS)

    Paunoiu, C.; Doca, C.

    2004-01-01

    The paper presents: a) some importance factors of the environmental pollution; b) the theoretical aspects of the Neutron Activation Analysis (NAA) used in the study of the environmental pollution; c) the NAA specific hardware and software facilities existing at the Institute for Nuclear Research; d) a direct application of the NAA method in the study of the environmental pollution for Pitesti city by the analysis of some ground and vegetation samples; e) results and conclusions. (authors)

  12. Home Environmental Factors Influencing Performance and Progress ...

    African Journals Online (AJOL)

    Our findings support other studies which found that parents' educational level and income level have a bearing on school progress and performance. Contrary to most research findings mother tongue instruction did not eme1rge as an important explanatory factor on school progress and performance, however; home ...

  13. Home Environmental Factors Influencing Performance and Progress ...

    African Journals Online (AJOL)

    2010-05-11

    May 11, 2010 ... internal factors for low school performance, this study focused on the learners ... Namibia. Although numerous studies have confinned socio-economic ... Many studies support the view that family background is the strongest single predictor of ..... Windhoek is clearly stratified, mainly following income levels.

  14. THE USE OF RELEVANT FACTORS FOR CONSUMERS IN DESIGNING A COMMUNICATIONAL MESSAGE

    Directory of Open Access Journals (Sweden)

    Olimpia OANCEA

    2014-06-01

    Full Text Available Today, organizations must adapt to the new realities of the environment in which they operate, and their efforts must be increasingly more oriented towards identifying the factors that influence consumer behavior, in particular economic, social and psychological aspects. When consumers are acting on incomplete information base, they assume automatically a risk for each purchasing decision. The size of the risk decreases depending on the quantity and relevance of information transmitted through communicational messages. Therefore, the aim of this paper is to highlight the factors that should be taken into account when designing a communicational message, so that this has to have the ability to change consumer attitudes and to keep constant interest to the products and / or services of a company.

  15. Relevant Factors for Establishing Inter-firm Cooperation Networks in Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Jorge Renato Verschoore

    2008-10-01

    Full Text Available The cooperation among firms in a network form has been stressed as an alternative organizational configuration in response to recent economic transformation. The increased number of initiatives and the empirical research scarcity on the network formation in Brazil motivated the present study. The main objective of this paper is to comprehend the factors which effect the establishment of network cooperation in the Southern Brazilian context. In order to achieve this objective a quantitative research was carried out with 443 enterprise representatives, associated to 120 cooperation networks. The empirical data were collected by the researchers in 2005 and statistically processed through a conjoint analysis. The results confirmed the theoretical propositions built by the researchers,appointing the relevance of factors, such as learning and innovation, increased scale and market power, and access to solutions.

  16. Relevance of genetically determined host factors to the prognosis of meningococcal disease.

    Science.gov (United States)

    Domingo, P; Muñiz-Diaz, E; Baraldès, M A; Arilla, M; Barquet, N; Pericas, R; Juárez, C; Madoz, P; Vázquez, G

    2004-08-01

    To assess the relevance of genetically determined host factors for the prognosis of meningococcal disease, Fc gamma receptor IIA (FcgammaRIIA), the tumor necrosis factor alpha (TNF-alpha) gene promoter region, and plasminogen-activator-inhibitor-1 (PAI-1) gene polymorphisms were studied in 145 patients with meningococcal disease and in 290 healthy controls matched by sex. Distribution of FcgammaRIIA, TNF-alpha, and PAI-1 alleles was not significantly different between patients and controls. Patients with the FcgammaRIIA-R/R 131 allotype scored > or =1 point in the Barcelona prognostic system more frequently than patients with other allotypes (odds ratio, 18.6; 95% confidence interval, 7.1-49.0, PFc gamma receptor IIA polymorphism was associated with markers of disease severity, but TNF-alpha and PAI-1 polymorphisms were not.

  17. Quantifying Environmental Limiting Factors on Tree Cover Using Geospatial Data

    NARCIS (Netherlands)

    Greenberg, Jonathan; Ferreira Dos Santos, Maria Joao; Dobrowski, Solomon; Vanderbilt, Vern; Ustin, Susan

    2015-01-01

    Environmental limiting factors (ELFs) are the thresholds that determine the maximum or minimum biological response for a given suite of environmental conditions. We asked the following questions: 1) Can we detect ELFs on percent tree cover across the eastern slopes of the Lake Tahoe Basin, NV? 2)

  18. Environmental factors influencing fluctuation of share prices on ...

    African Journals Online (AJOL)

    Environmental factors influencing fluctuation of share prices on Nigeria stock exchange market. ... What are these environmental variables that affect the fluctuation of share prices in Nigeria? ... The results show inflation, money supply, total deficits index of industrial production, interest rate and GDP influence stock prices.

  19. Environmental risk factors for oesophageal cancer in Malawi: A case ...

    African Journals Online (AJOL)

    Firewood cooking, cigarette smoking, and use of white maize flour all had ... Environmental exposures may be important risk factors ... Correspondence to: Nora E. Rosenberg ..... including in southern Africa.29 To our knowledge, this is the ...

  20. Environmental and genetic factors affecting faecal worm egg counts ...

    African Journals Online (AJOL)

    Environmental and genetic factors affecting faecal worm egg counts in Merinos divergently selected for reproduction. ... The fixed effect of birth year x sex interaction was significant, with rams showing higher mean values for FWEC than ewes ...

  1. Influence of environmental factors on birth weight variability of ...

    African Journals Online (AJOL)

    Administrator

    2011-05-30

    May 30, 2011 ... significant (P < 0.05). Type of birth also had effect on the body weight of lambs at birth in both Pirot and ... Key words: Environmental factors, birth weight variability, indigenous sheep. ... breeding plans to improve production.

  2. Analysis of corrosive environmental factors of seabed sediment

    Indian Academy of Sciences (India)

    Unknown

    Seabed sediment; corrosion; environmental factors. 1. Introduction. The corrosion ... plays an important role in the corrosion behaviour of steel in sediment. Figure 2b shows the change in oxidation-reduction po- tential, Eh with distance from ...

  3. Environmental Factors that Determine Visual Skill Development of ...

    African Journals Online (AJOL)

    2017-10-26

    Oct 26, 2017 ... development and environmental risk factors influencing it provides useful guide for early ..... sporting activities, video games, and play with large mobile toys .... in the brain: Implications for explaining autism. Science. 2005 ...

  4. Accuracy of Environmental Monitoring in China: Exploring the Influence of Institutional, Political and Ideological Factors

    Directory of Open Access Journals (Sweden)

    Daniele Brombal

    2017-02-01

    Full Text Available Environmental monitoring data are essential to informing decision-making processes relevant to the management of the environment. Their accuracy is therefore of extreme importance. The credibility of Chinese environmental data has been long questioned by domestic and foreign observers. This paper explores the potential impact of institutional, political, and ideological factors on the accuracy of China’s environmental monitoring data. It contends that the bureaucratic incentive system, conflicting agency goals, particular interests, and ideological structures constitute potential sources of bias in processes of environmental monitoring in China. The current leadership has acknowledged the issue, implementing new measures to strengthen administrative coordination and reinforce the oversight of the central government over local authorities. However, the failure to address the deeper political roots of the problem and the ambivalence over the desirability of public participation to enhance transparency might jeopardize Beijing’s strive for environmental data accuracy.

  5. Effects of environmental stressors on histone modifications and their relevance to carcinogenesis: a systematic review.

    NARCIS (Netherlands)

    Dik, S.; Scheepers, P.T.J.; Godderis, L.

    2012-01-01

    Carcinogenesis is a complex process involving both genetic and epigenetic mechanisms. The cellular molecular epigenetic machinery, including histone modifications, is associated with changes in gene expression induced by exposure to environmental agents. In this paper, we systematically reviewed

  6. Motivation factors for suicidal behavior and their clinical relevance in admitted psychiatric patients.

    Directory of Open Access Journals (Sweden)

    Naoki Hayashi

    Full Text Available Suicidal behavior (SB is a major, worldwide health concern. To date there is limited understanding of the associated motivational aspects which accompany this self-initiated conduct.To develop a method for identifying motivational features associated with SB by studying admitted psychiatric patients, and to examine their clinical relevance.By performing a factor analytic study using data obtained from a patient sample exhibiting high suicidality and a variety of SB methods, Motivations for SB Scale (MSBS was constructed to measure the features. Data included assessments of DSM-IV psychiatric and personality disorders, suicide intent, depressive symptomatology, overt aggression, recent life events (RLEs and methods of SB, collated from structured interviews. Association of identified features with clinical variables was examined by correlation analyses and MANCOVA.Factor analyses elicited a 4-factor solution composed of Interpersonal-testing (IT, Interpersonal-change (IC, Self-renunciation (SR and Self-sustenance (SS. These factors were classified according to two distinctions, namely interpersonal vs. intra-personal directedness, and the level of assumed influence by SB or the relationship to prevailing emotions. Analyses revealed meaningful links between patient features and clinical variables. Interpersonal-motivations (IT and IC were associated with overt aggression, low suicidality and RLE discord or conflict, while SR was associated with depression, high suicidality and RLE separation or death. Borderline personality disorder showed association with IC and SS. When self-strangulation was set as a reference SB method, self-cutting and overdose-taking were linked to IT and SS, respectively.The factors extracted in this study largely corresponded to factors from previous studies, implying that they may be useful in a wider clinical context. The association of these features with SB-related factors suggests that they constitute an integral part

  7. Effects of nanomolar cadmium concentrations on water plants - comparison of biochemical and biophysical mechanisms of toxicity under environmentally relevant conditions

    OpenAIRE

    Andresen, Elisa

    2014-01-01

    In this thesis, the effects of the highly toxic heavy metal cadmium (Cd) on the rootless aquatic model plant Ceratophyllum demersum are investigated on the biochemical and biophysical level. The experiments were carried out using environmentally relevant conditions, i.e. light and temperature followed a sinusoidal cycle, a low biomass to water ratio resembled the situation in oligotrophic lakes and a continuous exchange of the defined nutrient solution ensured that metal uptake into the plant...

  8. What factors are most relevant to the assessment of work ability of employees on long-term sick leave? The physicians' perspective.

    Science.gov (United States)

    Dekkers-Sánchez, Patricia M; Wind, Haije; Sluiter, Judith K; Frings-Dresen, Monique H W

    2013-07-01

    To reach insurance physician (IPs) consensus on factors that must be taken into account in the assessment of the work ability of employees who are sick-listed for 2 years. A Delphi study using online questionnaires was conducted from October 2010 to March 2011. One hundred and two insurance physicians reached a consensus on important factors for return to work (RTW) of employees on long-term sick leave; from those factors, the most relevant for the assessment of work ability was determined. From a total of 22 relevant factors considered for the return to work of long-term sick-listed employees, consensus was reached on nine relevant factors that need to be taken into account in the assessment of the work ability of employees on long-term sick leave. Relevant factors that support return to work are motivation, attitude towards RTW, assessment of cognitions and behaviour, vocational rehabilitation in an early stage and instruction for the sick-listed employee to cope with his disabilities. Relevant factors that hinder RTW are secondary gain from illness, negative perceptions of illness, inefficient coping style and incorrect advice of treating physicians regarding RTW. Non-medical personal and environmental factors may either hinder or promote RTW and must be considered in the assessment of the work ability of long-term sick-listed employees. Assessment of work ability should start early during the sick leave period. These factors may be used by IPs to improve the quality of the assessment of the work ability of employees on long-term sick leave.

  9. Multi-criteria Analysis of Factors for Application of Concrete Composites Considering Their Environmental Harmfulness

    Science.gov (United States)

    Paulikova, A.; Estokova, A.; Mitterpach, J.

    2017-10-01

    The analysis of factors is important in insight of the selection of proper building material with environmental added value. A comprehensive solution is possible if at the beginning there are all the relevant factors in detail characterized predominately that have got a major impact on the area in terms of environmentalharmfulness prevention. There are many groups of environmental factors. In this article only four factors are considered, i.e. contain of CrVI (mg/kg) and index of mass activity for radionuclides (Ra, Th, K) which are the most harmful. These factors can be evaluated by means of a supplementary tool, e.g. multi-criteriaanalysis, which improves and supports decision processes in the framework of construction bybuilding management, etc.

  10. Relevant factors to consider prior to an investor-owned acquisition of a nonprofit healthcare entity.

    Science.gov (United States)

    Ault, Kelvin; Childs, Brad; Wainright, Charles F; Young, Marilyn

    2011-01-01

    The purpose of this article is to explore the factors that affect the negotiations for an acquisition of a nonprofit system by an investor-owned entity. The recent economic downturn, accompanying credit crisis, and healthcare reform legislation will likely encourage and accelerate the pace of merger and acquisition (M&A) transactions between investor-owned entities and nonprofit hospitals. As many nonprofits are smaller, more financially vulnerable, and more limited in their access to capital than their investor-owned counterparts, nonprofits could be prime targets for investor-owned acquirers during the healthcare reform implementation period. In M&A transactions of this type, the investor-owned acquirer typically is motivated to pursue an acquisition when the deal promises an acceptable return on investment and decreased operating costs from economies of scale. Alternatively, the nonprofit target is typically seeking funding for upgrades to facilities and information technology systems as well as a continued commitment to charity care and managed-care contracting leverage. A successful acquisition of a nonprofit hospital by an investor-owned company requires a careful analysis of relevant tax, economic, and strategic factors prior to closing the deal. This article lists the most significant factors to consider in these deals and explains how these factors should influence the purchase price and postacquisition cash flow.

  11. Environmental factors and puberty timing: expert panel research needs

    DEFF Research Database (Denmark)

    Louis, G.M. Buck; Jr, L.E. Gray; Marcus, M.

    2008-01-01

    initiatives include (1) etiologic research that focus on environmentally relevant levels of endocrine-disrupting chemicals and body size in relation to normal puberty as well as its variants, (2) exposure assessment of relevant endocrine-disrupting chemicals during critical windows of human development......, body size, and puberty. The panel concluded that available experimental animal and human data support a possible role of endocrine-disrupting chemicals and body size in relation to alterations in pubertal onset and progression in boys and girls. Critical data gaps prioritized for future research...

  12. Social anxiety disorder: A review of environmental risk factors

    Directory of Open Access Journals (Sweden)

    Christina A Brook

    2008-03-01

    Full Text Available Christina A Brook, Louis A SchmidtDepartment of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ontario, CanadaAbstract: Social anxiety disorder (SAD is a debilitating and chronic illness characterized by persistent fear of one or more social or performance situations, with a relatively high lifetime prevalence of 7% to 13% in the general population. Although the last two decades have witnessed enormous growth in the study of biological and dispositional factors underlying SAD, comparatively little attention has been directed towards environmental factors in SAD, even though there has been much ongoing work in the area. In this paper, we provide a recent review and critique of proposed environmental risk factors for SAD, focusing on traditional as well as some understudied and overlooked environmental risk factors: parenting and family environment, adverse life events, cultural and societal factors, and gender roles. We also discuss the need for research design improvements and considerations for future directions.

  13. Mechanism of uranium(VI) uptake by Saccharomyces cerevisiae under environmentally relevant conditions: Batch, HRTEM, and FTIR studies

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Xia, E-mail: lux2009@lzu.edu.cn; Zhou, Xiao-jiao; Wang, Tie-shan, E-mail: tswang@lzu.edu.cn

    2013-11-15

    Highlights: • Equilibrium reaches very rapid within 15 min. • pH shift towards neutral indicates release of hydroxyl ions. • High ionic strength inhabits biosorption capacity. • Uptake capacity of heat-killed cells is an order of magnitude higher than live one. • Electrostatic interaction, precipitation, and complexation are the main mechanisms. -- Abstract: Biosorption is of significance for the safety evaluation of high-level nuclear wastes repositories and remediation of radioactive contamination places. Quantitive study and structural characterization of uranium uptake by both live and heat-killed Saccharomyces cerevisiae at environmentally relevant uranium concentration and with different ionic strengths were carried out. Kinetic investigation showed the equilibrium reached within 15 min. In equilibrium studies, pH shift towards neutral indicated release of hydroxyl ions. pH was the most important factor, which partly affected electrostatic interaction between uranyl ions and S. cerevisiae surface. The high ionic strength inhibited biosorption capacity, which can be explained by a competitive reaction between sodium ions and uranyl ions. Heat killing process significantly enhanced biosorption capacity, showing an order of magnitude higher than that of live cells. High resolution transmission electron microscopy (HRTEM) coupled with energy dispersive X-ray (EDX) showed needle-like uranium-phosphate precipitation formed on the cell walls for both live and heat-killed cells. Besides, dark-field micrographs displayed considerable similar uranium-phosphate precipitation presented outside the heat-killed cells. The phosphate released during heat-killing process. FTIR illustrated function groups hydroxyl, carboxyl, phosphate, and amino groups played important role in complexation with uranium.

  14. Which Environmental Factors Have the Highest Impact on the Performance of People Experiencing Difficulties in Capacity?

    Directory of Open Access Journals (Sweden)

    Verena Loidl

    2016-04-01

    Full Text Available Disability is understood by the World Health Organization (WHO as the outcome of the interaction between a health condition and personal and environmental factors. Comprehensive data about environmental factors is therefore essential to understand and influence disability. We aimed to identify which environmental factors have the highest impact on the performance of people with mild, moderate and severe difficulties in capacity, who are at risk of experiencing disability to different extents, using data from a pilot study of the WHO Model Disability Survey in Cambodia and random forest regression. Hindering or facilitating aspects of places to socialize in community activities, transportation and natural environment as well as use and need of personal assistance and use of medication on a regular basis were the most important environmental factors across groups. Hindering or facilitating aspects of the general environment were the most relevant in persons experiencing mild levels of difficulties in capacity, while social support, attitudes of others and use of medication on a regular basis were highly relevant for the performance of persons experiencing moderate to higher levels of difficulties in capacity. Additionally, we corroborate the high importance of the use and need of assistive devices for people with severe difficulties in capacity.

  15. Factors relevant to medication non-adherence in kidney transplant: a systematic review.

    Science.gov (United States)

    Belaiche, Stephanie; Décaudin, Bertrand; Dharancy, Sébastien; Noel, Christian; Odou, Pascal; Hazzan, Marc

    2017-06-01

    Background Medication non-adherence is a major issue after transplant that can lead to misdiagnosis, rejection, poor health affecting quality of life, graft loss or death. Several estimations of adherence and related factors have previously been described but conclusions leave doubt as to the most accurate assessment method. Aim of the review To identify the factors most relevant to medication non-adherence in kidney transplant in current clinical practice. Method This systematic review is registered in the PROSPERO data base and follows the Prisma checklist. Articles in English in three databases from January 2009 to December 2014 were analysed. A synthesis was made to target adherence assessment methods, their prevalence and significance. Results Thirty-seven studies were analysed rates of non-adherence fluctuating from 1.6 to 96%. Assessment methods varied from one study to another, although self-reports were mainly used. It appears that youth (≤50 years old), male, low social support, unemployment, low education, ≥3 months post graft, living donor, ≥6 comorbidities, ≥5 drugs/d, ≥2 intakes/d, negative beliefs, negative behavior, depression and anxiety were the factors significantly related to non-adherence. Conclusion As there are no established guidelines, consideration should be given to more than one approach to identify medication non-adherence although self-reports should remain the cornerstone of adherence assessment.

  16. Environmental Factors in China's Financial Accounting Development since 1949

    NARCIS (Netherlands)

    G. Zhang (Guohua)

    2005-01-01

    textabstractThe difference in environmental factors is one of the main reasons for the accounting difference among countries. It is also one of the critical factors to be first considered when studying and understanding one country’s accounting activities, and also when trying to harmonize and

  17. Environmental risk factors of childhood asthma in urban centers.

    OpenAIRE

    Malveaux, F J; Fletcher-Vincent, S A

    1995-01-01

    Asthma morbidity and mortality are disproportionately high in urban centers, and minority children are especially vulnerable. Factors that contribute to this dilemma include inadequate preventive medical care for asthma management, inadequate asthma knowledge and management skills among children and their families, psychosocial factors, and environmental exposure to allergens or irritants. Living in substandard housing often constitutes excess exposure to indoor allergens and pollutants. Alle...

  18. Environmental risk factors for REM sleep behavior disorder

    DEFF Research Database (Denmark)

    Postuma, R B; Montplaisir, J Y; Pelletier, A

    2012-01-01

    Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors...... for REM sleep behavior disorder....

  19. Effects of an environmentally-relevant mixture of pyrethroid insecticides on spontaneous activity in primary cortical networks on microelectrode arrays.

    Science.gov (United States)

    Johnstone, Andrew F M; Strickland, Jenna D; Crofton, Kevin M; Gennings, Chris; Shafer, Timothy J

    2017-05-01

    Pyrethroid insecticides exert their insecticidal and toxicological effects primarily by disrupting voltage-gated sodium channel (VGSC) function, resulting in altered neuronal excitability. Numerous studies of individual pyrethroids have characterized effects on mammalian VGSC function and neuronal excitability, yet studies examining effects of complex pyrethroid mixtures in mammalian neurons, especially in environmentally relevant mixture ratios, are limited. In the present study, concentration-response functions were characterized for five pyrethroids (permethrin, deltamethrin, cypermethrin, β-cyfluthrin and esfenvalerate) in an in vitro preparation containing cortical neurons and glia. As a metric of neuronal network activity, spontaneous mean network firing rates (MFR) were measured using microelectorde arrays (MEAs). In addition, the effect of a complex and exposure relevant mixture of the five pyrethroids (containing 52% permethrin, 28.8% cypermethrin, 12.9% β-cyfluthrin, 3.4% deltamethrin and 2.7% esfenvalerate) was also measured. Data were modeled to determine whether effects of the pyrethroid mixture were predicted by dose-addition. At concentrations up to 10μM, all compounds except permethrin reduced MFR. Deltamethrin and β-cyfluthrin were the most potent and reduced MFR by as much as 60 and 50%, respectively, while cypermethrin and esfenvalerate were of approximately equal potency and reduced MFR by only ∼20% at the highest concentration. Permethrin caused small (∼24% maximum), concentration-dependent increases in MFR. Effects of the environmentally relevant mixture did not depart from the prediction of dose-addition. These data demonstrate that an environmentally relevant mixture caused dose-additive effects on spontaneous neuronal network activity in vitro, and is consistent with other in vitro and in vivo assessments of pyrethroid mixtures. Published by Elsevier B.V.

  20. Identification of environmentally relevant chemicals in bibliographic databases: a comparative analysis

    DEFF Research Database (Denmark)

    Ellegaard, Ole; Wallin, Johan Albert

    2013-01-01

    takes as its starting point environmentally important chemicals and the retrieval of selectively chosen substances in the four databases: SciFinder, Web of Science (WoS), Scopus and Google Scholar. The way chemical data are stored in the databases plays a major role in the recovery process...

  1. Theses on the systematization of environmental law (relevant to regional planning)

    International Nuclear Information System (INIS)

    Erbguth, W.

    1987-01-01

    The 'Central Institute for Regional Planning' (Zentralinstitut fuer Raumplanung) of the University of Muenster carried out an extensive study on the systematization of environmental law. Hence it follows that particularly in the field of atomic law and the law for the protection against nuisance a landwide homogeneous planning level is missing. (WG) [de

  2. Effects of Environmentally Relevant Concentrations of Bisphenol A on the Fathead Minnow

    Science.gov (United States)

    Bisphenol A (BPA) is a wide-spread environmental contaminant of concern due, in part, to possible effects on the vertebrate hypothalamic-pituitary-gonadal (HPG) axis, including activation of the estrogen receptor (ER). There is a reasonable amount of toxicological information fo...

  3. Polychaete diversity and its relevance in the rapid environmental assessment of Mumbai Port

    Digital Repository Service at National Institute of Oceanography (India)

    Sukumaran, S.; SaralaDevi, K.

    , 469–474. 11. Reish, D. J., Effect of pollution abatement in Los Angeles harbors. Mar. Pollut. Bull., 1971, 2, 71–74. 12. Levin, L. A., Polychaetes as environmental indicators: response to low oxygen and organic enrichment. Bull. Mar. Sci., 2000, 67...

  4. Environmental performance of hydrothermal carbonization of four wet biomass waste streams at industry-relevant scales

    DEFF Research Database (Denmark)

    Owsianiak, Mikolaj; Ryberg, Morten; Renz, Michael

    2016-01-01

    . By contrast, hydrochar produced from the organic fraction of MSW performs best in 6 impact categories, but has high potential impacts on human health and ecosystems caused by emissions of toxic elements through ash disposal. The greatest potential for environmental optimization for the HTC technology...

  5. Iteratio: Calculating environmental indicator values for species and relevés.

    NARCIS (Netherlands)

    Holtland, W.J.; Braak, ter C.J.F.; Schouten, M.G.C.

    2010-01-01

    Question: Is it possible to translate vegetation maps into reliable thematic maps of site conditions? Method: This paper presents a new method, called Iteratio, by which a coherent spatial overview of specific environmental conditions can be obtained from a comprehensive vegetation survey of a

  6. Supramolecular Chemistry of Selective Anion Recognition for Anions of Environmental Relevance

    International Nuclear Information System (INIS)

    Bowman-James, K.; Wilson, G.; Moyer, B. A.

    2004-01-01

    This project involves the design and synthesis of receptors for oxoanions of environmental importance, including emphasis on high level and low activity waste. Target anions have included primarily oxoanions and a study of the basic concepts behind selective binding of target anions. A primary target has been sulfate because of its deleterious influence on the vitrification of tank wastes

  7. Impact of Environmental Factors on the Regulation of Cyanotoxin Production

    Science.gov (United States)

    Boopathi, Thangavelu; Ki, Jang-Seu

    2014-01-01

    Cyanobacteria are capable of thriving in almost all environments. Recent changes in climatic conditions due to increased human activities favor the occurrence and severity of harmful cyanobacterial bloom all over the world. Knowledge of the regulation of cyanotoxins by the various environmental factors is essential for effective management of toxic cyanobacterial bloom. In recent years, progress in the field of molecular mechanisms involved in cyanotoxin production has paved the way for assessing the role of various factors on the cyanotoxin production. In this review, we present an overview of the influence of various environmental factors on the production of major group of cyanotoxins, including microcystins, nodularin, cylindrospermopsin, anatoxins and saxitoxins. PMID:24967641

  8. PROTECTION OF PUBLIC INTEREST GUARANTEED BY ENVIRONMENTAL INSPECTION AND RELEVANT INSTITUTIONS

    Directory of Open Access Journals (Sweden)

    Ulsi Manja

    2017-12-01

    Full Text Available Albania's natural environment and resources are vital to its economic success and the health and well-being of its citizens. Environmental crime threatens resources on which it is heavily dependent on the pillars of the Albanian economy and acts as a major obstacle and obstacle as Albania moves towards an efficient economy with resources, employment and safe growth. The greatest challenges in today's environment do not conspire in natural disasters, but in the grave, immoral and inexperienced behavior of man to the environment and its elements. Impotence is another important element of this story that is killing us every day, though it does not seem to touch us with any expected tree, no bird that no longer has to stand, no fish that took the river's river hydroelectric power plant.... Inspection in particular, is an important part of environmental protection, because in my view it is the key to everything, based on the ever-popular popular expression "fear preserves the vineyard". The impotence of environmental crime is one of the most important advantages and methods for preserving environmental elements. Inspection in the entirety of many advantages in other instrument reports as a previously studied, well-defined, non-corroborated inspection is efficient both for the environment and economic efficiency, as it affects the ability to increase revenue publicity, transparency, flexibility, etc. Inspection today is considered to be the only pathway that affects law enforcement by all actors set out in it. It is the only tool that, having the authority to take administrative or criminal measures, directly affects the work and life of the objects subject to inspection. In this context, inspection has been successfully used to address a wide range of environmental crime, including waste disposal, water pollution and air emissions.

  9. Population impact of familial and environmental risk factors for schizophrenia

    DEFF Research Database (Denmark)

    Sørensen, Holger J; Nielsen, Philip R; Pedersen, Carsten B

    2014-01-01

    Although several studies have examined the relative contributions of familial and environmental risk factors for schizophrenia, few have additionally examined the predictive power on the individual level and simultaneously examined the population impact associated with a wide range of familial...... 4.50-5.31). The study showed that risk factors with highest predictive power on the individual level have a relatively low population impact. The challenge in future studies with direct genetic data is to examine gene-environmental interactions that can move research beyond current approaches...... and environmental risk factors. The authors present rate ratios (IRR), population-attributable risks (PAR) and sex-specific cumulative incidences of the following risk factors: parental history of mental illness, urban place of birth, advanced paternal age, parental loss and immigration status. We established...

  10. Quantifying environmental limiting factors on tree cover using geospatial data.

    Directory of Open Access Journals (Sweden)

    Jonathan A Greenberg

    Full Text Available Environmental limiting factors (ELFs are the thresholds that determine the maximum or minimum biological response for a given suite of environmental conditions. We asked the following questions: 1 Can we detect ELFs on percent tree cover across the eastern slopes of the Lake Tahoe Basin, NV? 2 How are the ELFs distributed spatially? 3 To what extent are unmeasured environmental factors limiting tree cover? ELFs are difficult to quantify as they require significant sample sizes. We addressed this by using geospatial data over a relatively large spatial extent, where the wall-to-wall sampling ensures the inclusion of rare data points which define the minimum or maximum response to environmental factors. We tested mean temperature, minimum temperature, potential evapotranspiration (PET and PET minus precipitation (PET-P as potential limiting factors on percent tree cover. We found that the study area showed system-wide limitations on tree cover, and each of the factors showed evidence of being limiting on tree cover. However, only 1.2% of the total area appeared to be limited by the four (4 environmental factors, suggesting other unmeasured factors are limiting much of the tree cover in the study area. Where sites were near their theoretical maximum, non-forest sites (tree cover < 25% were primarily limited by cold mean temperatures, open-canopy forest sites (tree cover between 25% and 60% were primarily limited by evaporative demand, and closed-canopy forests were not limited by any particular environmental factor. The detection of ELFs is necessary in order to fully understand the width of limitations that species experience within their geographic range.

  11. Genetic and environmental factors affecting birth size variation

    DEFF Research Database (Denmark)

    Yokoyama, Yoshie; Jelenkovic, Aline; Hur, Yoon-Mi

    2018-01-01

    Background: The genetic architecture of birth size may differ geographically and over time. We examined differences in the genetic and environmental contributions to birthweight, length and ponderal index (PI) across geographical-cultural regions (Europe, North America and Australia, and East Asia......) and across birth cohorts, and how gestational age modifies these effects. Methods: Data from 26 twin cohorts in 16 countries including 57 613 monozygotic and dizygotic twin pairs were pooled. Genetic and environmental variations of birth size were estimated using genetic structural equation modelling....... Results: The variance of birthweight and length was predominantly explained by shared environmental factors, whereas the variance of PI was explained both by shared and unique environmental factors. Genetic variance contributing to birth size was small. Adjusting for gestational age decreased...

  12. A metabolomic study of fipronil for the anxiety-like behavior in zebrafish larvae at environmentally relevant levels

    International Nuclear Information System (INIS)

    Wang, Cui; Qian, Yi; Zhang, Xiaofeng; Chen, Fang; Zhang, Quan; Li, Zhuoyu; Zhao, Meirong

    2016-01-01

    Field residue of fipronil can interfere with the physiological characters of the domesticated fish; thus, lethal dose test and the general biomarker cannot delineate the low-level situation. Manipulating by video track, we observed an anxiety-like behavior including high speed and abnormal photoperiod accommodation after exposure to fipronil at environmental typical dose in zebrafish larvae. Examining the unbiased metabolomic profiles, we found perturbation in several metabolic pathways, including the increased contents of fatty acids and glycerol and the decreased levels of the glycine, serine, and branched amino acid. We presumed that observed enhanced fatty acid utility was in response to increase energy demands caused by anxiety like behavior. Additionally, the body burden of neurotransmitter such as glycine and L-glutamate may concurrently stimulate the swimming behavior. The insight of this study showed that integral perturbation such as metabolism helps us to further understand the risk to aquatic fish at the environmentally relevant levels. - Highlights: • Fipronil increased the swimming speed at 10 μg/L to zebrafish larvae. • Accommodation to light–dark photoperiod switch was disturbed by fipronil. • Metabolomics indicated an increase energy availability for anxiety-like behavior. • Anxiety-like behavior induced by fipronil may attribute to neurotransmitter changes. - Zebrafish larvae exposed to environmentally relevant concentrations of fipronil display anxiety like behavior that may attribute to observed changes in energy utilization and neurotransmitter disturbances.

  13. Environmental regulation of households. An empirical review of economic and psychological factors

    International Nuclear Information System (INIS)

    Van den Bergh, Jeroen C.J.M.

    2008-01-01

    The literature on sustainable consumption and environmental regulation of household behavior is dominated by conceptual and normative approaches. As a result, many suggestions lack a firm empirical basis. To overcome this deficiency, econometric studies in three areas of environmentally relevant activities of households are reviewed: residential use of energy, generation of solid waste and recycling, and residential use of water. Next to price and income elasticities, attention is devoted to individual socio-economic features and psychological factors, such as attitudes, knowledge, perceptions and values. Potential psychological determinants and related insights are further examined by discussing a range of representative and illustrative statistical-psychological studies of environmental behavior. One important general finding is that there are very few empirical studies that systematically combine socio-economic and psychological determinants. A range of insights for environmental policy is derived, and research recommendations are offered. (author)

  14. Assessment of relevant factors and relationships concerning human dermal exposure to pesticides in greenhouse applications.

    Science.gov (United States)

    Martínez Vidal, Jose L; Egea González, Francisco J; Garrido Frenich, Antonia; Martínez Galera, María; Aguilera, Pedro A; López Carrique, Enrique

    2002-08-01

    Principal component analysis (PCA) was applied to the gas chromatographic data obtained from 23 different greenhouse trials. This was used to establish which factors, including application technique (very small, small, medium and large drop-size), crop characteristics (short/tall, thin/dense) and pattern application of the operator (walking towards or away from the treated area) are relevant to the dermal exposure levels of greenhouse applicators. The results showed that the highest exposure by pesticides during field applications in greenhouses, in the climatic conditions and in the crop conditions typical of a southern European country, occurs on the lower legs and front thighs of the applicators. Similar results were obtained by hierarchical cluster analysis (HCA). Drop-size seems to be very important in determining total exposure, while height and density of crops have little influence on total exposure under the conditions of the present study. No pesticide type is a major factor in total exposure. The application of multiple regression analysis (MRA) allowed assessment of the relationships between the pesticide exposure of the less affected parts of the body with the most affected parts.

  15. How pharmacist-patient communication determines pharmacy loyalty? Modeling relevant factors.

    Science.gov (United States)

    Patrícia Antunes, Liliana; Gomes, João José; Cavaco, Afonso Miguel

    2015-01-01

    Portuguese community pharmacies provide pharmaceutical services, such as therapeutic outcomes follow-up, supplemented by relevant point-of-care testing that require continuity of provision to be effective. To identify factors of technical and communication nature that during a patient interview contribute to patients' loyalty. A cross-sectional descriptive study, with a purposive sample of community pharmacies providing pharmaceutical care, was conducted. Patient interviews were taped and transcribed verbatim. Duration, segments and utterances were identified and time stamped, using a previously validated coding scheme. To identify predictors of loyalty, logistic regression analyses were performed. From 59 interviews, participants' average age was 65.7 years and 42 (71.2%) were female; 45 (76.3%) interviews were classified as outcomes measurements and 14 (23.7%) as pharmaceutical consultations, with 33.2% of the patients booking a following appointment. The significant items to explain loyalty were associated with lifestyle and psychosocial exchange, age of the patient, and the presence of all interview segments (i.e. a complete consultation). Contrary to common professional beliefs and practice orientation it would appear that pharmacists' technical skills are not the essential factors that promote patients' loyalty needed for continuity of care, at least in the same extent as the social and lifestyle-related content of the exchange. Pharmaceutical care education should focus on relational skills as much as on medication-related competencies. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. Comparison of extraction techniques for isolation of steroid oestrogens in environmentally relevant concentrations from sediment

    Czech Academy of Sciences Publication Activity Database

    Sadílek, Jan; Spálovská, P.; Vrana, B.; Vávrová, M.; Maršálek, Blahoslav; Šimek, Z.

    2016-01-01

    Roč. 96, č. 11 (2016), s. 1022-1037 ISSN 0306-7319 Institutional support: RVO:67985939 Keywords : microwave - assisted extraction * estrogens * sediment Subject RIV: CB - Analytical Chemistry , Separation Impact factor: 1.208, year: 2016

  17. Factors Influencing Environmental Scanning in the Organizational Context

    Directory of Open Access Journals (Sweden)

    Zita Correia

    2001-01-01

    Full Text Available This paper identifies and analyses the factors internal to the organization, which affect the activity of environmental scanning, understood here as the information seeking activity of managers, directed at the company's external environment. These factors include individual factors, such as information consciousness and exposure to information, and organizational factors such as information climate and "outwardness". The main relationships among them are also analysed. These factors were identified in the course of research aiming to provide a comprehensive understanding of the environmental scanning process (Correia & Wilson, 1996. The methodology used - a case-study approach coupled with the grounded theory method of qualitative analysis - was of major importance in obtaining information that is grounded largely on the personal experience of managers.

  18. Epigenetic Effect of Environmental Factors on Autism Spectrum Disorders

    Directory of Open Access Journals (Sweden)

    Takeo Kubota

    2016-05-01

    Full Text Available Both environmental factors and genetic factors are involved in the pathogenesis of autism spectrum disorders (ASDs. Epigenetics, an essential mechanism for gene regulation based on chemical modifications of DNA and histone proteins, is also involved in congenital ASDs. It was recently demonstrated that environmental factors, such as endocrine disrupting chemicals and mental stress in early life, can change epigenetic status and gene expression, and can cause ASDs. Moreover, environmentally induced epigenetic changes are not erased during gametogenesis and are transmitted to subsequent generations, leading to changes in behavior phenotypes. However, epigenetics has a reversible nature since it is based on the addition or removal of chemical residues, and thus the original epigenetic status may be restored. Indeed, several antidepressants and anticonvulsants used for mental disorders including ASDs restore the epigenetic state and gene expression. Therefore, further epigenetic understanding of ASDs is important for the development of new drugs that take advantages of epigenetic reversibility.

  19. Epigenetic Effect of Environmental Factors on Autism Spectrum Disorders.

    Science.gov (United States)

    Kubota, Takeo; Mochizuki, Kazuki

    2016-05-14

    Both environmental factors and genetic factors are involved in the pathogenesis of autism spectrum disorders (ASDs). Epigenetics, an essential mechanism for gene regulation based on chemical modifications of DNA and histone proteins, is also involved in congenital ASDs. It was recently demonstrated that environmental factors, such as endocrine disrupting chemicals and mental stress in early life, can change epigenetic status and gene expression, and can cause ASDs. Moreover, environmentally induced epigenetic changes are not erased during gametogenesis and are transmitted to subsequent generations, leading to changes in behavior phenotypes. However, epigenetics has a reversible nature since it is based on the addition or removal of chemical residues, and thus the original epigenetic status may be restored. Indeed, several antidepressants and anticonvulsants used for mental disorders including ASDs restore the epigenetic state and gene expression. Therefore, further epigenetic understanding of ASDs is important for the development of new drugs that take advantages of epigenetic reversibility.

  20. The relevance of social theory in the practice of environmental management

    CSIR Research Space (South Africa)

    Meissner, Richard

    2015-09-01

    Full Text Available as follows. In the first part I define the concepts ‘paradigm’, ‘theory’ and ‘ethics’. The purpose of this section is to show the difference between a paradigm and a theory and to lay the foundation for the rest of the article. I also illustrate the link... between paradigms and theories and ethics, and by implication practice. I follow this part with Rosenau’s (2003) argument that we are all theorists; the purpose of which is to highlight that environmental assessment practitioners use paradigms...

  1. Antisperm antibodies as a factor of male infertility. Relevance, modern methods of diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    O. A. Nikiforov

    2017-08-01

    Full Text Available According to WHO statistics 40 % of childless marriage is due to factors of male infertility. One of them is the presence of antisperm antibodies in the male organism, which may be in blood serum, on the surface of spermatozoids and seminal plasma. Aim. Оn the grounds of specialized literature analysis, to show the relevance of this problem in Reproductive Medicine, to descript Basic methods of Modern treatment and diagnosis of this pathology in the body of infertile males. The most common methods of antisperm antibodies identifying are: MAR-test sample Shuvarskiy–Sims–Hyuner, Kurtsrok–Miller test, the method of latex agglutination, solid-phase immunoenzymatic blood test. Indications for antisperm antibodies determining are: modified indices, deviations in post-coital test, a negative test of sperm and cervical mucus interaction in vitro, unexplained infertility in the married couples, failure or low indices during IVF (in vitro fertilization and of course, the exclusion of other causes of infertility. When antisperm antibodies are detected, the strategy of treatment may be destined to reduction of their titer for further pregnancy. Such types of therapy can be used: contraceptive (long-term use contraception barrier to reduce antisperm antibodies titer in women, plasmapheresis, artificial insemination with pretreated from antisperm antibodies husband's sperm, methods of assisted reproductive technologies. Conclusoins. The formation of antisperm antibodies leads to infertility of immunological genesis (in 20 % of couples with unexplained infertility. To confirm their presence in the male body it is necessary to perform the MAR-test, Shuvarsky test, other tests and, of course, the exclusion of other causes of infertility. Men of reproductive age with an immunological factor of infertility provides for a comprehensive treatment, including elimination of all possible causative and contributing factors of infertility (infection of the male

  2. Proteomic Assessment of the Relevant Factors Affecting Pork Meat Quality Associated with Muscles in Duroc Pigs

    Directory of Open Access Journals (Sweden)

    Jin Hyoung Cho

    2016-11-01

    Full Text Available Meat quality is a complex trait influenced by many factors, including genetics, nutrition, feeding environment, animal handling, and their interactions. To elucidate relevant factors affecting pork quality associated with oxidative stress and muscle development, we analyzed protein expression in high quality longissimus dorsi muscles (HQLD and low quality longissimus dorsi muscles (LQLD from Duroc pigs by liquid chromatographytandem mass spectrometry (LC-MS/MS–based proteomic analysis. Between HQLD (n = 20 and LQLD (n = 20 Duroc pigs, 24 differentially expressed proteins were identified by LC-MS/MS. A total of 10 and 14 proteins were highly expressed in HQLD and LQLD, respectively. The 24 proteins have putative functions in the following seven categories: catalytic activity (31%, ATPase activity (19%, oxidoreductase activity (13%, cytoskeletal protein binding (13%, actin binding (12%, calcium ion binding (6%, and structural constituent of muscle (6%. Silver-stained image analysis revealed significant differential expression of lactate dehydrogenase A (LDHA between HQLD and LQLD Duroc pigs. LDHA was subjected to in vitro study of myogenesis under oxidative stress conditions and LDH activity assay to verification its role in oxidative stress. No significant difference of mRNA expression level of LDHA was found between normal and oxidative stress condition. However, LDH activity was significantly higher under oxidative stress condition than at normal condition using in vitro model of myogenesis. The highly expressed LDHA was positively correlated with LQLD. Moreover, LDHA activity increased by oxidative stress was reduced by antioxidant resveratrol. This paper emphasizes the importance of differential expression patterns of proteins and their interaction for the development of meat quality traits. Our proteome data provides valuable information on important factors which might aid in the regulation of muscle development and the improvement of

  3. Factors influencing environmental attitude: The relationship between environmental attitude defensibility and cognitive reasoning level

    Science.gov (United States)

    Yount, James R.; Horton, Phillip B.

    The purpose of this study was to investigate the relationship between factors believed to contribute to the formation of environmental attitudes by college nonscience majors. Key relationships addressed were the effects of a university environmental studies course on (a) environmental attitudes, (b) the amount of factual information that is brought to bear on an environmental attitude decision (defensibility), and (c) the linkages between the affective and the cognitive domains of freshman and sophomore students. When compared to the control group, the students who attended an environmental studies class did not significantly change their attitudes, but they did exhibit increases in their total [F(3, 132) = 5.91, p cognitive reasoning scores were more prone to increase defensibility [F(6, 129) = 3.78, p cognitive and affective domains in the environmental attitude decision-making process.

  4. Low impact of exposure to environmentally relevant doses of 226Ra in Atlantic cod (Gadus morhua) embryonic cells

    International Nuclear Information System (INIS)

    Olsvik, Pål A.; Berntssen, Marc H.G.; Hylland, Ketil; Eriksen, Dag Ø.; Holen, Elisabeth

    2012-01-01

    The aim of this study was to investigate whether 226 Ra, a radionuclide present in produced water from oil platforms in the North Sea and other offshore drilling areas, could affect vulnerable early life stages of Atlantic cod (Gadus morhua). Blastula-stage embryonic cells (EC) from fertilized eggs of Atlantic cod were isolated and exposed to environmental relevant concentrations of 226 Ra and transcription of selected genes quantified. The results showed a weak, but significant up-regulation of GPx3 and HSP70 transcripts after 48 h of exposure to 2.11 Bq/L. In EC exposed to three 226 Ra concentrations (2.11, 23 and 117 Bq/L) for 12 h, metallothionein, HSP90AA, thioredoxin and caspase 8 were significantly up-regulated in cells exposed to 117 Bq/L, whereas thioredoxin was also significantly up-regulated in EC exposed to 23 Bq/L. When EC were exposed to the same 226 Ra concentrations for 48 h, only heme oxygenase was significantly up-regulated in the 23 Bq/L exposure group. The results suggest that environmentally relevant activities of 226 Ra may induce oxidative stress and apoptosis in fish ECs. Exposure of Atlantic cod EC to Cd, selected as a model toxicant, supported the ability of EC around blastula stage to respond to toxicants by altered transcription. Due to dilution, environmentally relevant concentrations of radionuclides present in produced water would be expected to pose a minor threat to early life stages of fish. - Highlights: ► 226 Ra affects the transcription of genes in Atlantic cod embryonic cells. ► 226 Ra may induce oxidative stress and apoptosis in fish embryonic cells. ► 226 Ra not expected to pose a major threat to early life stages of marine fish.

  5. Assessing population and environmental effects on thermal resistance in Drosophila melanogaster using ecologically relevant assays

    DEFF Research Database (Denmark)

    Overgaard, Johannes; Hoffmann, Ary A; Kristensen, Torsten Nygård

    2011-01-01

    To make laboratory studies of thermal resistance in ectotherms more ecologically relevant, temperature changes that reflect conditions experienced by individuals in nature should be used. Here we describe an assay that is useful for quantifying multiple measures of thermal resistance of individual...... adult flies. We use this approach to assess upper and lower thermal limits and functional thermal scope for Drosophila melanogaster and also show that the method can be used to (1) detect a previously described latitudinal cline for cold tolerance in D. melanogaster populations collected along the east...... thermal environments have wider thermal limits compared to those from the less variable tropics, at least when flies were reared under constant temperature conditions and (4) demonstrate that different measures of cold resistance are often not strongly correlated. Based on our findings, we suggest...

  6. Environmental mixtures of nanomaterials and chemicals: The Trojan-horse phenomenon and its relevance for ecotoxicity.

    Science.gov (United States)

    Naasz, Steffi; Altenburger, Rolf; Kühnel, Dana

    2018-04-22

    The usage of engineered nanomaterials (NM) offers many novel products and applications with advanced features, but at the same time raises concerns with regard to potential adverse biological effects. Upon release and emission, NM may interact with chemicals in the environment, potentially leading to a co-exposure of organisms and the occurrence of mixture effects. A prominent idea is that NM may act as carriers of chemicals, facilitating and enhancing the entry of substances into cells or organisms, subsequently leading to an increased toxicity. In the literature, the term 'Trojan-horse effect' describes this hypothesis. The relevance of this mechanism for organisms is, however, unclear as yet. Here, a review has been performed to provide a more systematic picture on existing evidence. It includes 151 experimental studies investigating the exposure of various NM and chemical mixtures in ecotoxicological in vitro and in vivo model systems. The papers retrieved comprised studies investigating (i) uptake, (ii) toxicity and (iii) investigations considering both, changes in substance uptake and toxicity upon joint exposure of a chemical with an NM. A closer inspection of the studies demonstrated that the existing evidence for interference of NM-chemical mixture exposure with uptake and toxicity points into different directions compared to the original Trojan-horse hypothesis. We could discriminate at least 7 different categories to capture the evidence ranging from no changes in uptake and toxicity to an increase in uptake and toxicity upon mixture exposure. Concluding recommendations for the consideration of relevant processes are given, including a proposal for a nomenclature to describe NM-chemical mixture interactions in consistent terms. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

  7. Importance and variability in processes relevant to environmental tritium ingestion dose models

    International Nuclear Information System (INIS)

    Raskob, W.; Barry, P.

    1997-01-01

    The Aiken List was devised in 1990 to help decide which transport processes should be investigated experimentally so as to derive the greatest improvement in performance of environmental tritium assessment models. Each process was rated high, medium and low on each of two criteria. These were ''Importance'', which rated processes by how much each contributed to ingestion doses, and ''State of Modelling'', which rated the adequacy of the knowledge base on which models were built. Ratings, though unanimous, were, nevertheless, qualitative and subjective opinions. This paper describes how we have tried to quantify the ratings. To do this, we use, as measures of ''Importance'', sensitivities of predicted ingestion doses to changes in values of parameters in mathematical descriptions of individual processes. Measures of ''ModellinStatus'' were taken from a recently completed BIOMOVS study of HTO transport model performance and based either on by how much predicted transport by individual processes differed amongst participating modellers or by the variety of different ways that modellers chose to describe individual processes. The tritium transport model UFOTRI was used, and because environmental transport of HTO varies according to the weather at and after release time, sensitivities were measured in a sample of all conditions likely to arise in central Europe. (Author)

  8. Using Magnetically Responsive Tea Waste to Remove Lead in Waters under Environmentally Relevant Conditions

    KAUST Repository

    Yeo, Siang Yee; Choi, Siwon; Dien, Vivian; Sow-Peh, Yoke Keow; Qi, Genggeng; Hatton, T. Alan; Doyle, Patrick S.; Thio, Beng Joo Reginald

    2013-01-01

    We report the use of a simple yet highly effective magnetite-waste tea composite to remove lead(II) (Pb2+) ions from water. Magnetite-waste tea composites were dispersed in four different types of water–deionized (DI), artificial rainwater, artificial groundwater and artificial freshwater–that mimic actual environmental conditions. The water samples had varying initial concentrations (0.16–5.55 ppm) of Pb2+ ions and were mixed with the magnetite-waste tea composite for at least 24 hours to allow adsorption of the Pb2+ ions to reach equilibrium. The magnetite-waste tea composites were stable in all the water samples for at least 3 months and could be easily removed from the aqueous media via the use of permanent magnets. We detected no significant leaching of iron (Fe) ions into the water from the magnetite-waste tea composites. The percentage of Pb adsorbed onto the magnetite-waste tea composite ranged from ~70% to 100%; the composites were as effective as activated carbon (AC) in removing the Pb2+ ions from water, depending on the initial Pb concentration. Our prepared magnetite-waste tea composites show promise as a green, inexpensive and highly effective sorbent for removal of Pb in water under environmentally realistic conditions.

  9. Using Magnetically Responsive Tea Waste to Remove Lead in Waters under Environmentally Relevant Conditions

    KAUST Repository

    Yeo, Siang Yee

    2013-06-20

    We report the use of a simple yet highly effective magnetite-waste tea composite to remove lead(II) (Pb2+) ions from water. Magnetite-waste tea composites were dispersed in four different types of water–deionized (DI), artificial rainwater, artificial groundwater and artificial freshwater–that mimic actual environmental conditions. The water samples had varying initial concentrations (0.16–5.55 ppm) of Pb2+ ions and were mixed with the magnetite-waste tea composite for at least 24 hours to allow adsorption of the Pb2+ ions to reach equilibrium. The magnetite-waste tea composites were stable in all the water samples for at least 3 months and could be easily removed from the aqueous media via the use of permanent magnets. We detected no significant leaching of iron (Fe) ions into the water from the magnetite-waste tea composites. The percentage of Pb adsorbed onto the magnetite-waste tea composite ranged from ~70% to 100%; the composites were as effective as activated carbon (AC) in removing the Pb2+ ions from water, depending on the initial Pb concentration. Our prepared magnetite-waste tea composites show promise as a green, inexpensive and highly effective sorbent for removal of Pb in water under environmentally realistic conditions.

  10. Characteristics of malaria vector breeding habitats in Sri Lanka: relevance for environmental management

    DEFF Research Database (Denmark)

    Hoek, Wim van der; Amerasinghe, F P; Konradsen, F

    1998-01-01

    , potential secondary vectors, were characterized by site, exposure to sunlight, substratum, turbidity of the water, presence of vegetation, and presence of fauna. Availability of pools of stagnant water in the stream near the village and along the edge of the village tank was highly predictive for presence......In and around a village in the Anuradhapura District of Sri Lanka anopheline larvae were sampled from July 1994 to April 1996 in all surface water bodies. Samples positive for Anopheles culicifacies, the established vector of malaria in Sri Lanka, and for An. barbirostris, An. vagus, and An. varuna...... clear water pools, was able to exploit habitats that were shaded and contained turbid water. Environmental management interventions to control An. culicifacies breeding have to take into account that the secondary vectors of malaria exploit other habitats and would not be affected by the interventions....

  11. Neurotoxic effects of perfluoroalkylated compounds: mechanisms of action and environmental relevance.

    Science.gov (United States)

    Mariussen, Espen

    2012-09-01

    Perfluoroalkylated compounds (PFCs) are used in fire-fighting foams, treatment of clothes, carpets and leather products, and as lubricants, pesticides, in paints and medicine. Recent developments in chemical analysis have revealed that fluorinated compounds have become ubiquitously spread and are regarded as a potential threats to the environment. Due to the carbon-fluorine bond, which has a very high bond strength, these chemicals are extremely persistent towards degradation and some PFCs have a potential for bioaccumulation in organisms. Of particular concern has been the developmental toxicity of PFOS and PFOA, which has been manifested in rodent studies as high mortality of prenatally exposed newborn rats and mice within 24 h after delivery. The nervous system appears to be one of the most sensitive targets of environmental contaminants. The serious developmental effects of PFCs have lead to the upcoming of studies that have investigated neurotoxic effects of these substances. In this review the major findings of the neurotoxicity of the main PFCs and their suggested mechanisms of action are presented. The neurotoxic effects are discussed in light of other toxic effects of PFCs to indicate the significance of PFCs as neurotoxicants. The main findings are that PFCs may induce neurobehavioral effects, particularly in developmentally exposed animals. The effects are, however, subtle and inconclusive and are often induced at concentrations where other toxic effects also are expected. Mechanistic studies have shown that PFCs may affect the thyroid system, influence the calcium homeostasis, protein kinase C, synaptic plasticity and cellular differentiation. Compared to other environmental toxicants the human blood levels of PFCs are high and of particular concern is that susceptible groups may be exposed to a cocktail of substances that in combination reach harmful concentrations.

  12. NELCAS, an efficient and relevant tool to assess key environmental indicators for nuclear energy - 5334

    International Nuclear Information System (INIS)

    Bourg, S.; Poinssot, C.; Ouvrier, N.; Serp, J.

    2015-01-01

    Full text of publication follows. Nuclear energy is anticipated to be one of the possible energy sources which can allow the production of energy at high load with a high level of reliability without significant impact on the environment, specifically in terms of green-house gases. It could therefore promote the mitigation of the anticipated global climate change. However, nuclear energy is regularly questioned about its overall environmental impact and footprint, in particular after the Fukushima accident. However, very little information is available on the actual footprint of current and future nuclear systems. In order to bring insights on this issue, we developed a Life Cycle Assessment (LCA) simulation tool NELCAS based on the French nuclear system which allows the calculation of representative key environmental indicators and potential impact indicators for the whole nuclear systems. Indicators were chosen based on their occurrence in literature. Calculations were performed while considering the whole fuel cycle from ore-mining to geological repository and for each of the plant, the contribution from their construction, their operation and their future cleaning and dismantling. Transports were also considered all along the fuel cycle. All the matters and energy fluxes were considered and normalized versus the electric production. Whenever it is possible, actual and recent data were collected. In particular we widely used the Transparency and Safety Annual reports issued for each fuel cycle plant in France. Finally, statistical influence of the severe accidents was also considered based on the recent Fukushima accident. This presentation will detail the methodology and the overall results obtained for the different indicators. A specific emphasis will be given on the relative benefice of the nuclear energy by comparison to other energy sources. (authors)

  13. Isotopically modified silver nanoparticles to assess nanosilver bioavailability and toxicity at environmentally relevant exposures

    Science.gov (United States)

    Croteau, Marie-Noële; Dybowska, Agnieszka D.; Luoma, Samuel N.; Misra, Superb K.; Valsami-Jones, Eugenia

    2014-01-01

    A major challenge in understanding the environmental implications of nanotechnology lies in studying nanoparticle uptake in organisms at environmentally realistic exposure concentrations. Typically, high exposure concentrations are needed to trigger measurable effects and to detect accumulation above background. But application of tracer techniques can overcome these limitations. Here we synthesised, for the first time, citrate-coated Ag nanoparticles using Ag that was 99.7 % 109Ag. In addition to conducting reactivity and dissolution studies, we assessed the bioavailability and toxicity of these isotopically modified Ag nanoparticles (109Ag NPs) to a freshwater snail under conditions typical of nature. We showed that accumulation of 109Ag from 109Ag NPs is detectable in the tissues of Lymnaea stagnalis after 24-h exposure to aqueous concentrations as low as 6 ng L–1 as well as after 3 h of dietary exposure to concentrations as low as 0.07 μg g–1. Silver uptake from unlabelled Ag NPs would not have been detected under similar exposure conditions. Uptake rates of 109Ag from 109Ag NPs mixed with food or dispersed in water were largely linear over a wide range of concentrations. Particle dissolution was most important at low waterborne concentrations. We estimated that 70 % of the bioaccumulated 109Ag concentration in L. stagnalis at exposures –1 originated from the newly solubilised Ag. Above this concentration, we predicted that 80 % of the bioaccumulated 109Ag concentration originated from the 109Ag NPs. It was not clear if agglomeration had a major influence on uptake rates.

  14. Repository environmental parameters and models/methodologies relevant to assessing the performance of high-level waste packages in basalt, tuff, and salt

    Energy Technology Data Exchange (ETDEWEB)

    Claiborne, H.C.; Croff, A.G.; Griess, J.C.; Smith, F.J.

    1987-09-01

    This document provides specifications for models/methodologies that could be employed in determining postclosure repository environmental parameters relevant to the performance of high-level waste packages for the Basalt Waste Isolation Project (BWIP) at Richland, Washington, the tuff at Yucca Mountain by the Nevada Test Site, and the bedded salt in Deaf Smith County, Texas. Guidance is provided on the identify of the relevant repository environmental parameters; the models/methodologies employed to determine the parameters, and the input data base for the models/methodologies. Supporting studies included are an analysis of potential waste package failure modes leading to identification of the relevant repository environmental parameters, an evaluation of the credible range of the repository environmental parameters, and a summary of the review of existing models/methodologies currently employed in determining repository environmental parameters relevant to waste package performance. 327 refs., 26 figs., 19 tabs.

  15. Repository environmental parameters and models/methodologies relevant to assessing the performance of high-level waste packages in basalt, tuff, and salt

    International Nuclear Information System (INIS)

    Claiborne, H.C.; Croff, A.G.; Griess, J.C.; Smith, F.J.

    1987-09-01

    This document provides specifications for models/methodologies that could be employed in determining postclosure repository environmental parameters relevant to the performance of high-level waste packages for the Basalt Waste Isolation Project (BWIP) at Richland, Washington, the tuff at Yucca Mountain by the Nevada Test Site, and the bedded salt in Deaf Smith County, Texas. Guidance is provided on the identify of the relevant repository environmental parameters; the models/methodologies employed to determine the parameters, and the input data base for the models/methodologies. Supporting studies included are an analysis of potential waste package failure modes leading to identification of the relevant repository environmental parameters, an evaluation of the credible range of the repository environmental parameters, and a summary of the review of existing models/methodologies currently employed in determining repository environmental parameters relevant to waste package performance. 327 refs., 26 figs., 19 tabs

  16. Phytoaccumulation of antimicrobials from biosolids: impacts on environmental fate and relevance to human exposure.

    Science.gov (United States)

    Aryal, Niroj; Reinhold, Dawn M

    2011-11-01

    Triclocarban and triclosan, two antimicrobials widely used in consumer products, can adversely affect ecosystems and potentially impact human health. The application of biosolids to agricultural fields introduces triclocarban and triclosan to soil and water resources. This research examined the phytoaccumulation of antimicrobials, effects of plant growth on migration of antimicrobials to water resources, and relevance of phytoaccumulation in human exposure to antimicrobials. Pumpkin, zucchini, and switch grass were grown in soil columns to which biosolids were applied. Leachate from soil columns was assessed every other week for triclocarban and triclosan. At the end of the trial, concentrations of triclocarban and triclosan were determined for soil, roots, stems, and leaves. Results indicated that plants can reduce leaching of antimicrobials to water resources. Pumpkin and zucchini growth significantly reduced soil concentrations of triclosan to less than 0.001 mg/kg, while zucchini significantly reduced soil concentrations of triclocarban to 0.04 mg/kg. Pumpkin, zucchini, and switch grass accumulated triclocarban and triclosan in mg per kg (dry) concentrations. Potential human exposure to triclocarban from consumption of pumpkin or zucchini was substantially less than exposure from product use, but was greater than exposure from drinking water consumption. Consequently, research indicated that pumpkin and zucchini may beneficially impact the fate of antimicrobials in agricultural fields, while presenting minimal acute risk to human health. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. Cultural Factors relevant to Korean Americans in Health Research: A Systematic Review.

    Science.gov (United States)

    Shin, Cha-Nam; Keller, Colleen; Sim, Jeongha

    2018-04-01

    To eliminate health disparities in the United States, identifying cultural contexts salient to the target populations in an intervention study is critical; however, little research has been conducted on the identification of cultural contexts among Korean Americans who have significant risk factors for chronic diseases. This systematic review identifies critical cultural contexts central to the literature discussed in health research on Korean Americans. We examined 14 research reports of 801 potentially eligible articles published between 2000 and 2016 and analyzed their contribution to cultural contexts among Korean Americans based on the PEN-3 model. This review highlights how cultural contexts impact health and health behaviors of Korean Americans, and may contribute to health disparities in the United States. The key cultural contexts highlighted in this review include social support/social network, family, gender role expectations, and a holistic view of health and illness. These cultural contexts should be incorporated in designing culturally relevant, effective, and sustainable health interventions for Korean Americans, which will contribute to eliminating health disparities for this ethnic group who experience great obstacles to healthcare access and healthy behaviors.

  18. Overview of Macrophage Migration Inhibitory Factor (MIF as a Potential Biomarker Relevant to Adiposity

    Directory of Open Access Journals (Sweden)

    Jun Nishihira

    2012-07-01

    Full Text Available The cytokine “macrophage migration inhibitory factor (MIF” is generally recognized as a proinflammatory cytokine, and MIF is involved in broad range of acute and chronic inflammatory states. With regard to glucose metabolism and insulin secretion, MIF is produced by pancreatic β cells and acts as a positive regulator of insulin secretion. In contrast, it is evident that MIF expressed in adipose tissues causes insulin resistance. Concerning MIF gene analysis, we found four alleles: 5-, 6-, 7-and 8-CATT at position −794 of MIF gene in a Japanese population. Genotypes without the 5-CATT allele were more common in the obese subjects than in the lean or overweight groups. It is conceivable that promoter polymorphism in the MIF gene is profoundly linked with obesity relevant to lifestyle diseases, such as diabetes. Obesity has become a serious social issue due to the inappropriate nutritional balance, and the consumption of functional foods (including functional foods to reduce fat mass is expected to overcome this issue. In this context, MIF would be a reliable quantitative biomarker to evaluate the effects of functional foods on adiposity.

  19. FTO is a relevant factor for the development of the metabolic syndrome in mice.

    Directory of Open Access Journals (Sweden)

    Kathrin Ikels

    Full Text Available The metabolic syndrome is a worldwide problem mainly caused by obesity. FTO was found to be a obesity-risk gene in humans and FTO deficiency in mice led to reduction in adipose tissue. Thus, FTO is an important factor for the development of obesity. Leptin-deficient mice are a well characterized model for analysing the metabolic syndrome. To determine the relevance of FTO for the development of the metabolic syndrome we analysed different parameters in combined homozygous deficient mice (Lep(ob/ob;Fto(-/-. Lep(ob/ob;Fto(-/- mice showed an improvement in analysed hallmarks of the metabolic syndrome in comparison to leptin-deficient mice wild type or heterozygous for Fto. Lep(ob/ob;Fto(-/- mice did not develop hyperglycaemia and showed an improved glucose tolerance. Furthermore, extension of beta-cell mass was prevented in Lep(ob/ob;Fto(-/-mice and accumulation of ectopic fat in the liver was reduced. In conclusion this study demonstrates that FTO deficiency has a protective effect not only on the development of obesity but also on the metabolic syndrome. Thus, FTO plays an important role in the development of metabolic disorders and is an interesting target for therapeutic agents.

  20. Rating the Relevant Factors of Business Conditions for Entrepreneurs in Serbia

    Directory of Open Access Journals (Sweden)

    Jovanka Popovic

    2016-05-01

    Full Text Available In this paper were processed and analyzed the attitudes and opinions of potential entrepreneurs regarding to starting their own businesses, in order to scan favorable conditions for development of entrepreneurship in Serbia. As a basic research instrument, a questionnaire with questions about the possibilities and limitations of entrepreneurial business was designed, with the task of identification and assessment of relevant factors that condition the operations of entrepreneurs in Serbia. Throughout the conducted research, it was concluded there are numerous obstacles to business start-ups and successful growth and development of entrepreneurship in Serbia. Participants of the survey believe they have competencies for starting their own business, but due to the unfavorable market conditions and the lack of financial resources, do not see themselves as employers. Analyzing of efforts and time, as well as the risks they take, it is concluded that most of them are not motivated to engage in entrepreneurship and does not plan a professional career in that field.

  1. Physical and chemical trigger factors in environmental intolerance.

    Science.gov (United States)

    Claeson, Anna-Sara; Palmquist, Eva; Nordin, Steven

    2018-04-01

    Individuals with environmental intolerance (EI) react to exposure from different environmental sources at levels tolerated by most people and that are below established toxicological and hazardous thresholds. The main aim of this study was to determine the prevalence of attributing symptoms to chemical and physical sources in the environment among individuals with different forms of self-reported EI and in referents. Cross-sectional data from a population-based study, the Västerbotten Environmental Health Study (n = 3406), were used and individuals with self-reported EI to chemicals, buildings, electromagnetic fields and sounds as well as a group with multiple EIs were identified. The Environmental-Symptom Attribution Scale was used to quantify degree to which health symptoms are attributed to 40 specific environmental exposures and sources, with subscales referring to the four types of EI. All EI groups, except the group with building related intolerance (BRI), reported more symptoms from the expected sources compared to the referents. In addition, individuals with chemical and sound intolerance reported symptoms from building related trigger factors, and individuals with electromagnetic hypersensitivity reported symptoms from chemical trigger factors. The study suggests that individuals with BRI react to fewer and more specific trigger factors than do individuals with other EIs, and that it is important to ask about different sources since three of the EI groups attribute their symptoms to a wide variety of sources in addition to the sources to which their EI implicates. Copyright © 2018 Elsevier GmbH. All rights reserved.

  2. Environmental & lifestyle factors in deterioration of male reproductive health

    Directory of Open Access Journals (Sweden)

    Sunil Kumar

    2014-01-01

    Full Text Available Background & objectives: Male reproductive function in the general population has been receiving attention in recent years due to reports of various reproductive and developmental defects, which might be associated with various lifestyle and environmental factors. This study was carried out to determine the role of various lifestyle and environmental factors in male reproduction and their possible association with declining semen quality, increased oxidative stress as well as sperm DNA damage. Methods: Semen samples were obtained from 240 male partners of the couples consulting for infertility problem. Semen analysis was carried out using WHO criteria and subjects were categorized on the basis of self reported history of lifestyle as well as environmental exposure. The oxidative and antioxidant markers; lipid peroxidation (LPO, superoxide dismutase (SOD and catalase (CAT as well as DNA damage by acridine orange test (AO were determined. Results: The presence of abnormal semen parameters was significantly higher among the lifestyle and/or environmental exposed subjects as compared to the non-exposed population. Further, the levels of antioxidants were reduced and sperm DNA damage was more among the lifestyle and/or environmental exposed subjects, though the changes were not significant. Interpretation & conclusions: These findings indicated that various lifestyle factors such as tobacco smoking, chewing and alcohol use as well as exposure to toxic agents might be attributed to the risk of declining semen quality and increase in oxidative stress and sperm DNA damage.

  3. Effect of environmental factors on intelligence quotient of children

    Directory of Open Access Journals (Sweden)

    Archita Makharia

    2016-01-01

    Full Text Available Introduction: A child's intelligence quotient (IQ is determined by both genetic and environmental factors that start from the prenatal period itself. There is a lack of data on the factors which influence IQ in Indian children; therefore, we conducted a multicenter questionnaire-based study to determine the environmental factors which influence IQ in Indian children. Participants and Methods: In this cross-sectional observational study, we recruited 1065 schoolchildren between the age of 12 and 16 years from 2 government and 13 private schools in 5 towns, 6 cities, and 2 villages across India. All the children were administered a questionnaire consisting of various environmental factors such as parents' education, occupation, income, and the physical activity of the students. IQ scores were assessed using Ravens Standard Progressive Matrices. An approximate IQ score was calculated using the score on the Ravens test. IQ scores were divided into three groups: below normal IQ (0–79, normal IQ (80–119, and high IQ (above 120. The data were analyzed using SPSS software. Results: In this study, it was observed that the environmental factors such as place of residence, physical activity, family income, parental education, and occupation of the father had an impact on the IQ of the children. Children living in cities (P = 0.001, children having physical activity more than 5 h/weeks (P = 0.001, children with parents having a postgraduate or graduate level of education (P = 0.001, children whose father having a professional job (P = 0.001, and those with a higher family income (P = 0.001 were more likely to have high IQ. Conclusions: In the present study, we found that various environmental factors such as place of residence, physical exercise, family income, parents' occupation and education influence the IQ of a child to a great extent. Hence, a child must be provided with an optimal environment to be able to develop to his/her full genetic

  4. Transfer and concentration factors in laboratory and environmental conditions

    International Nuclear Information System (INIS)

    Paschoa, A.S.; Amaral, E.C.S.

    1993-01-01

    Environmental transfer factors, as well as concentration and accumulation factors, have been increasingly used in environmental dosimetric models. These models are often the basis for decision-making processes concerning radiological protection. However, the uncertainties associated with measured and default values of transfer and concentration factors are usually not taken into account in the decision making processes. In addition, laboratory-based values for these factors do not necessarily agree with site-specific and species-specific transfer and concentration factors. Soil-to-plant transfer factors and water-to-aquatic-organisms concentration factors are not only time and concentration-dependent, but also species-and site-specific environment-dependent. These uncertainties and dependencies may make the decision-making process, based on models, quite a difficult exercise. The current work examines, as an example, the time-dependent variations in the accumulation of 226 Ra in zooplankton in a laboratory experiment as compared with the concentration factor measured in a natural environment. In addition, the work reviews differences in 228 Ra and 226 Ra concentration factors for several plant families measured in a highly radioactive environment. (author). 9 refs, 3 figs, 3 tabs

  5. A Sensitivity Analysis Approach to Identify Key Environmental Performance Factors

    Directory of Open Access Journals (Sweden)

    Xi Yu

    2014-01-01

    Full Text Available Life cycle assessment (LCA is widely used in design phase to reduce the product’s environmental impacts through the whole product life cycle (PLC during the last two decades. The traditional LCA is restricted to assessing the environmental impacts of a product and the results cannot reflect the effects of changes within the life cycle. In order to improve the quality of ecodesign, it is a growing need to develop an approach which can reflect the changes between the design parameters and product’s environmental impacts. A sensitivity analysis approach based on LCA and ecodesign is proposed in this paper. The key environmental performance factors which have significant influence on the products’ environmental impacts can be identified by analyzing the relationship between environmental impacts and the design parameters. Users without much environmental knowledge can use this approach to determine which design parameter should be first considered when (redesigning a product. A printed circuit board (PCB case study is conducted; eight design parameters are chosen to be analyzed by our approach. The result shows that the carbon dioxide emission during the PCB manufacture is highly sensitive to the area of PCB panel.

  6. Repair of radiation damage in mammalian cells: its relevance to environmental effects

    International Nuclear Information System (INIS)

    Han, A.; Elkind, M.M.

    1979-01-01

    Assessment of the potential biological hazards associated with energy production technologies involves the quantitation of risk on the basis of dose-effect dependencies, from which, it is hoped, some safety guidelines can be developed. Our current knowledge of the biological importance of damage/repair processes stems by and large from radiation studies which clearly demonstrate that cellular response to radiation depends upon the ability of cells to repair the damage. Apparently, the same is true for cellular response to different chemical agents. Drawing upon our experiences from radiation studies, we demonstrate the relevance of ongoing repair processes, as evident in the studies of radiation induced cell killing and neoplastic transformation, to the type of risk estimates that might be associated with the hazards from energy production technologies. The effect of repair on cell survival is considered. It is evident from our studies that in the region of small doses, repair of damage relative to cell lethality is of importance in estimating the magnitude of effect. Aside from the cytotoxic effects in terms of cell killing, one of the greatest concerns associated with energy production is the potential of a given technology, or its effluents, to produce cancer. It is therefore of importance to quantify the risk in this context of damage registration and possible effect of repair on damage expression. It has been generally established that exposure of normal cells in culture to a variety of known carcinogens results in neoplastic transformation. Our observations with C3H/10T1/2 cells in culture lend direct evidence for the hypothesis that reduced tumor incidences at low dose rates of radiation could be due to the repair of induced damage

  7. Environmental risk factors for oesophageal cancer in Malawi: A case ...

    African Journals Online (AJOL)

    Methods A hospital-based case-control study of the association between environmental risk factors and oesophageal cancer was conducted at Kamuzu Central Hospital in Lilongwe, Malawi and Queen Elizabeth Central Hospital in Blantyre, Malawi. Ninety-six persons with squamous cell carcinoma and 180 controls were ...

  8. Environmental factors influencing milk urea nitrogen in South African ...

    African Journals Online (AJOL)

    By knowing the milk urea nitrogen (MUN) content of dairy cows, the efficiency of dietary nitrogen utilization can be improved. The main objectives of this study were to identify and quantify environmental factors affecting MUN in South African Holstein cows. This will enable better interpretation of MUN results by accounting ...

  9. Influence of environmental factors on birth weight variability of ...

    African Journals Online (AJOL)

    The present investigation was carried out to study the influence of environmental factors on the birth weight variability of two breeds of sheep. Animals used in this research were taken from the Pirot and Svrljig indigenous sheep breeds. The data were collected from 1999 to 2009 and were analyzed to determine the effect of ...

  10. Influence of breed and environmental factors on litter parameters of ...

    African Journals Online (AJOL)

    Influence of breed and environmental factors on litter parameters of rabbits ... There was a non-significant effect of season on litter site at birth, kits alive at birth and ... to rabbit reproduction as it influenced negatively more litter parameters than ...

  11. Influence of some environmental factors on maize productivity in ...

    African Journals Online (AJOL)

    Temperature, humidity and direction of the prevailing wind are parts of significant environmental factors, which have greater impact on crop productivity, especially with the recent global climate change. These were researched into on maize seeds planted at three different furrow orientations on the field; Or. 900, Or. 600 and ...

  12. Cell functional enviromics: Unravelling the function of environmental factors

    Directory of Open Access Journals (Sweden)

    Alves Paula M

    2011-06-01

    Full Text Available Abstract Background While functional genomics, focused on gene functions and gene-gene interactions, has become a very active field of research in molecular biology, equivalent methodologies embracing the environment and gene-environment interactions are relatively less developed. Understanding the function of environmental factors is, however, of paramount importance given the complex, interactive nature of environmental and genetic factors across multiple time scales. Results Here, we propose a systems biology framework, where the function of environmental factors is set at its core. We set forth a "reverse" functional analysis approach, whereby cellular functions are reconstructed from the analysis of dynamic envirome data. Our results show these data sets can be mapped to less than 20 core cellular functions in a typical mammalian cell culture, while explaining over 90% of flux data variance. A functional enviromics map can be created, which provides a template for manipulating the environmental factors to induce a desired phenotypic trait. Conclusion Our results support the feasibility of cellular function reconstruction guided by the analysis and manipulation of dynamic envirome data.

  13. Interrelation and interaction level of dental health and environmental factors

    Directory of Open Access Journals (Sweden)

    Davydova N.V.

    2011-03-01

    Full Text Available The structure and intensity of dental disease among the examinees of the same sex and adolescence. The relationship of the influence of some environmental, nutritional and endogenous factors on the manifestation of dental caries and anomalies of occlusion

  14. Applicable or Relevant and Appropriate Requirements (ARARs) for Remedial Action at the Oak Ridge Reservation: A compendium of major environmental laws. Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    Etnier, E.L.; McDonald, E.P.; Houlberg, L.M.

    1993-07-01

    Section 121 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980 specifies that remedial actions for cleanup of hazardous substances must comply with applicable or relevant and appropriate requirements (ARARS) or standards under federal and state environmental laws. The US Department of Energy (DOE) Oak Ridge Reservation (ORR) was placed on the National Priorities List by the US Environmental Protection Agency (EPA) on November 21, 1989, effective December 21, 1989. As a result of this listing, DOE, EPA, and the Tennessee Department of Environment and Conservation have signed a Federal Facility Agreement (FFA) for the environmental restoration of the ORR. Section XXI(F) of the FFA calls for the preparation of a draft listing of all ARARs as mandated by CERCLA {section}121. This report supplies a preliminary list of available federal and state ARARs that might be considered for remedial response at the ORR. A description of the terms ``applicable`` and ``relevant and appropriate`` is provided, as well as definitions of chemical-, location-, and action-specific ARARS. ARARs promulgated by the federal government and by the state of Tennessee are listed in tables. In addition, the major provisions of the Resource Conservation and Recovery Act, the Safe Drinking Water Act, the Clean Water Act, the Clean Air and other acts, as they apply to hazardous waste cleanup, are discussed. In the absence of ARARS, CERCLA {section}121 provides for the use of nonpromulgated federal criteria, guidelines, and advisories in evaluating the human risk associated with remedial action alternatives. Such nonpromulgated standards are classified as ``to-be-considered`` (TBC) guidance. A ion of available guidance is given; summary tables fist the available federal standards and guidance information. In addition, the substantive contents of the DOE orders as they apply to remediation of radioactively contaminated sites are discussed as TBC guidance.

  15. Factors Behind the Environmental Kuznets Curve. A Decomposition of the Changes in Air Pollution

    Energy Technology Data Exchange (ETDEWEB)

    Bruvoll, Annegrete [Research Department, Statistics Norway, Oslo (Norway); Medin, Hege [Norwegian Institute of International Affairs, Oslo (Norway)

    2003-01-01

    The environmental Kuznets curve theory suggests that economic growth in the long run may reduce environmental problems. In this article, we use a decomposition analysis to isolate eight different factors, in order to investigate the origins of changes in emissions to air over the period from 1980 to 1996. Among these factors are economic growth, changes in the relative size of production sectors and changes in the use of energy. Given constant emissions per produced unit, economic growth alone would have contributed to a significant increase in the emissions. This potential degradation of the environment has been counteracted by first of all more efficient use of energy and abatement technologies. In addition, the substitution of cleaner for polluting energy types and other technological progressions and political actions have reduced the growth in emissions. Consequently, the growth in all emissions has been significantly lower than economic growth, and negative for some pollutants. The results indicate that policymakers may reduce emissions considerably through creating incentives for lower energy use and substitutions of environmental friendly for environmental damaging energy types, in addition to support environmental friendly research or to conduct direct emission reducing actions, such as abatement requirements or banning of environmental damaging products. This is particularly relevant to countries and sectors with relatively high energy intensities and low pollution abatement.

  16. An electron microscopy based method for the detection and quantification of nanomaterial number concentration in environmentally relevant media

    Energy Technology Data Exchange (ETDEWEB)

    Prasad, A. [School of Geography, Earth and Environmental Sciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom); Lead, J.R., E-mail: jlead@mailbox.sc.edu [School of Geography, Earth and Environmental Sciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom); Center for Environmental Nanoscience and Risk, Department of Environmental Health Sciences, Arnold School of Public Health, University South Carolina, Columbia 29208, SC (United States); Baalousha, M., E-mail: mbaalous@mailbox.sc.edu [Center for Environmental Nanoscience and Risk, Department of Environmental Health Sciences, Arnold School of Public Health, University South Carolina, Columbia 29208, SC (United States)

    2015-12-15

    Improved detection and characterization of nanomaterials (NMs) in complex environmental media requires the development of novel sampling approaches to improve the detection limit to be close to environmentally realistic concentrations. Transmission electron microscopy (TEM) is an indispensable metrological tool in nanotechnology and environmental nanoscience due to its high spatial resolution and analytical capabilities when coupled to spectroscopic techniques. However, these capabilities are hampered by the conventional sample preparation methods, which suffer from low NM recovery. The current work presents a validated, fully quantitative sampling technique for TEM that overcomes conventional sample preparation shortcomings, and thus enables the use of TEM for measurement of particle number concentration and their detection in complex media at environmentally realistic concentrations. This sampling method is based on ultracentrifugation of NMs from suspension onto a poly-L-lysine (PLL) functionalized TEM grid, using active deposition (by ultracentrifugation) and retention (by PLL interactions with NM surface) of NMs on the substrate, enabling fully quantitative analysis. Similar analysis with AFM was satisfactory in simple media but the lack of chemical-selectivity of AFM limits its applicability for the detection of NMs in complex environmental samples. The sampling approach was validated using both citrate- and PVP-coated AuNMs in pure water, which demonstrated an even distribution of NM on the TEM grid and high NM recovery (80–100%) at environmentally relevant NM concentrations (ca. 0.20–100 μg L{sup −1}). The applicability of the sampling method to complex environmental samples was demonstrated by the quantification of particle number concentration of AuNMs in EPA soft water (with and without Suwannee River fulvic acid) and lake water. This sample preparation approach is also applicable to other types of NMs with some modifications (e.g. centrifugation

  17. An electron microscopy based method for the detection and quantification of nanomaterial number concentration in environmentally relevant media

    International Nuclear Information System (INIS)

    Prasad, A.; Lead, J.R.; Baalousha, M.

    2015-01-01

    Improved detection and characterization of nanomaterials (NMs) in complex environmental media requires the development of novel sampling approaches to improve the detection limit to be close to environmentally realistic concentrations. Transmission electron microscopy (TEM) is an indispensable metrological tool in nanotechnology and environmental nanoscience due to its high spatial resolution and analytical capabilities when coupled to spectroscopic techniques. However, these capabilities are hampered by the conventional sample preparation methods, which suffer from low NM recovery. The current work presents a validated, fully quantitative sampling technique for TEM that overcomes conventional sample preparation shortcomings, and thus enables the use of TEM for measurement of particle number concentration and their detection in complex media at environmentally realistic concentrations. This sampling method is based on ultracentrifugation of NMs from suspension onto a poly-L-lysine (PLL) functionalized TEM grid, using active deposition (by ultracentrifugation) and retention (by PLL interactions with NM surface) of NMs on the substrate, enabling fully quantitative analysis. Similar analysis with AFM was satisfactory in simple media but the lack of chemical-selectivity of AFM limits its applicability for the detection of NMs in complex environmental samples. The sampling approach was validated using both citrate- and PVP-coated AuNMs in pure water, which demonstrated an even distribution of NM on the TEM grid and high NM recovery (80–100%) at environmentally relevant NM concentrations (ca. 0.20–100 μg L"−"1). The applicability of the sampling method to complex environmental samples was demonstrated by the quantification of particle number concentration of AuNMs in EPA soft water (with and without Suwannee River fulvic acid) and lake water. This sample preparation approach is also applicable to other types of NMs with some modifications (e.g. centrifugation

  18. Selective uptake and biological consequences of environmentally relevant antidepressant pharmaceutical exposures on male fathead minnows

    Science.gov (United States)

    Schultz, Melissa M.; Painter, Meghan M.; Bartell, Stephen E.; Logue, Amanda; Furlong, Edward T.; Werner, Stephen L.; Schoenfuss, Heiko L.

    2011-01-01

    Antidepressant pharmaceuticals have been reported in wastewater effluent at the nanogram to low microgram-per-liter range, and include bupropion (BUP), fluoxetine (FLX), sertraline (SER), and venlafaxine (VEN). To assess the effects of antidepressants on reproductive anatomy, physiology, and behavior, adult male fathead minnows (Pimeplwles promelas) were exposed for 21 days either to a single concentration of the antidepressants FLX, SER, VEN, or BUP, or to an antidepressant mixture. The data demonstrated that exposure to VEN (305 ng/L and 1104 ng/L) and SER (5.2 ng/L) resulted in mortality. Anatomical alterations were noted within the testes of fish exposed to SER and FLX, both modulators of the neurotransmitter serotonin. Additionally, FLX at 28 ng/L induced vitellogenin in male fish—a common endpoint for estrogenic endocrine disruption. Significant alterations in male secondary sex characteristics were noted with single exposures. Effects of single compound exposures neither carried over, nor became additive in the antidepressant mixtures, and reproductive behavior was not affected. Analysis of brain tissues from the exposed fish suggested increased uptake of FLX, SER and BUP and minimal uptake of VEN when compared to exposure water concentrations. Furthermore, the only metabolite detected consistently in the brain tissues was norfluoxetine. Similar trends of uptake by brain tissue were observed when fish were exposed to antidepressant mixtures. The present study demonstrates that anatomy and physiology, but not reproductive behavior, can be disrupted by exposure to environmental concentrations of some antidepressants. The observation that antidepressant uptake into fish tissues is selective may have consequences on assessing the mode-of-action and effects of these compounds in future studies.

  19. Environmental factors affecting inflammatory bowel disease: have we made progress?

    Science.gov (United States)

    Lakatos, Peter Laszlo

    2009-01-01

    The pathogenesis of inflammatory bowel disease (IBD) is only partially understood; various environmental and host (e.g. genetic, epithelial, immune, and nonimmune) factors are involved. The critical role for environmental factors is strongly supported by recent worldwide trends in IBD epidemiology. One important environmental factor is smoking. A meta-analysis partially confirms previous findings that smoking was found to be protective against ulcerative colitis and, after the onset of the disease, might improve its course, decreasing the need for colectomy. In contrast, smoking increases the risk of developing Crohn's disease and aggravates its course. The history of IBD is dotted by cyclic reports on the isolation of specific infectious agents responsible for Crohn's disease or ulcerative colitis. The more recently published cold chain hypothesis is providing an even broader platform by linking dietary factors and microbial agents. An additional, recent theory has suggested a breakdown in the balance between putative species of 'protective' versus 'harmful' intestinal bacteria - this concept has been termed dysbiosis resulting in decreased bacterial diversity. Other factors such as oral contraceptive use, appendectomy, dietary factors (e.g. refined sugar, fat, and fast food), perinatal events, and childhood infections have also been associated with both diseases, but their role is more controversial. Nonetheless, there is no doubt that economic development, leading to improved hygiene and other changes in lifestyle ('westernized lifestyle') may play a role in the increase in IBD. This review article focuses on the role of environmental factors in the pathogenesis and progression of IBDs. Copyright 2009 S. Karger AG, Basel.

  20. Early stress responses in Atlantic salmon (Salmo salar) exposed to environmentally relevant concentrations of uranium

    International Nuclear Information System (INIS)

    Song You; Salbu, Brit; Heier, Lene Sørlie; Teien, Hans-Christian; Lind, Ole-Christian; Oughton, Deborah; Petersen, Karina; Rosseland, Bjørn Olav; Skipperud, Lindis; Tollefsen, Knut Erik

    2012-01-01

    Uranium (U) is a naturally occurring heavy metal widely used in many military and civil applications. Uranium contamination and the associated potential adverse effects of U on the aquatic environment have been debated during recent years. In order to understand the effect and mode of action (MoA) of U in vivo, juvenile Atlantic salmon (Salmo salar) were exposed to 0.25 mg/L, 0.5 mg/L and 1.0 mg/L waterborne depleted uranyl acetate, respectively, in a static system for 48 h. The U concentrations in the gill and liver were analyzed by inductively coupled plasma mass spectrometry (ICP-MS) and the resulting biological effects were determined by a combination of analysis of gene expression and micronuclei formation. The hepatic transcriptional level of 12 biomarker genes from four stress–response categories, including oxidative stress (γ-glutamyl cysteine synthetase (GCS), glutathione reductase (GR), glutathione peroxidase (GPx)), DNA damage and repair (P53, cyclin-dependent kinase inhibitor 1 (P21), growth arrest and DNA damage-inducible gene gamma (Gadd45G), proliferating cell nuclear antigen (PCNA), Rad51), apoptosis (Bcl2-associated X protein (BAX), Bcl-x, Caspase 6A,) and protein degradation (Ubiquitin) were evaluated by quantitative real-time polymerase chain reaction (q-rtPCR). The results clearly showed accumulation of U in the gill and liver with increasing concentrations of U in the exposure water. The effects of U on differential hepatic gene expression also occurred in a concentration-dependent manner, although deviations from ideal concentration–response relationships were observed at the highest U concentration (1.0 mg/L). All the genes tested were found to be up-regulated by U while no significant micronuclei formation was identified. The results suggest that U may cause oxidative stress in fish liver at concentrations greater than 0.25 mg/L, giving rise to clear induction of several toxicologically relevant biomarker genes, although no significant

  1. Assessment of Environmental Factors of Geology on Waste and Engineering Barriers for Waste Storage Near Surface

    International Nuclear Information System (INIS)

    Arimuladi SP

    2007-01-01

    Geological environment factors include features and processes occurring within that spatial and temporal (post-closure) domain whose principal effect is to determine the evolution of the physical, chemical, biological and human conditions of the domain that are relevant to estimating the release and migration of radionuclide and consequent exposure to man. Hardness of radioactive waste and engineer barrier can be decrease by environmental factors. Disposal system domain geological environment factors is a category in the International FEP list and is divided into sub-categories. There are 13 sub-factors of geological environment, 12 sub-factors influence hardness of radioactive waste and engineer barrier, thermal processes and conditions in geosphere can be excluded. (author)

  2. Demographic, genetic, and environmental factors that modify disease course.

    Science.gov (United States)

    Marrie, Ruth Ann

    2011-05-01

    As with susceptibility to disease, it is likely that multiple factors interact to influence the phenotype of multiple sclerosis and long-term disease outcomes. Such factors may include genetic factors, socioeconomic status, comorbid diseases, and health behaviors, as well as environmental exposures. An improved understanding of the influence of these factors on disease course may reap several benefits, such as improved prognostication, allowing us to tailor disease management with respect to intensity of disease-modifying therapies and changes in specific health behaviors, in the broad context of coexisting health issues. Such information can facilitate appropriately adjusted comparisons within and between populations. Elucidation of these factors will require careful study of well-characterized populations in which the roles of multiple factors are considered simultaneously. Copyright © 2011 Elsevier Inc. All rights reserved.

  3. FACTORS OF NANOTECHNOLOGY AND BIODIVERSITY: ENVIRONMENTAL AND EDUCATIONAL ASPECTS

    Directory of Open Access Journals (Sweden)

    A. V. Kozachek

    2015-01-01

    Full Text Available The aim is to consider the features of impact of nanotechnology on biodiversity in the future.Methods. We suggest an approach, according to which nanotechnologies are viewed as key technologies of the sixth technological order. It is assumed that nanotechnology may be a potential source of environmental problems of the future, and the basis for the creation of new advanced types of environmental engineering and technology. Since all of the above is important both within the actual environmental performance and for the purposes of professional engineering and environmental training. We suggest in this paper to view the problem of the impact of nanotechnology on biodiversity and the state of the environment through environmental and educational aspects.Results. We considered and analyzed the environmental and educational aspects of the application of nanotechnology in the period of the sixth technological order. Implementing procedures for their analysis has contributed to the identification and systematization of the various impacts of nanotechnology on biodiversity and the state of the environment, and identification of options for the prevention of such factors. Based on the results of such studies we have identified educational aspects of training environmental engineers during the sixth technological order; defined a new focus of the training in the sixth technological order, which involves, in our opinion, the study of features of a rational and prudent use of natural resources with the use of appropriate innovative eco-oriented nanotechnology, education of students in terms of the understanding of the causes, consequences and ways to prevent the global resource crisis on the planet due to the emergence of a new class of nano-contamination.Main conclusions. The results can be recommended to be used in practice for more in-depth analysis of the specific environmental challenges of nanotechnology, and revising approaches to the design of the

  4. Reduced cellular DNA repair capacity after environmentally relevant arsenic exposure. Influence of Ogg1 deficiency

    International Nuclear Information System (INIS)

    Bach, Jordi; Peremartí, Jana; Annangi, Balasubramnayam; Marcos, Ricard; Hernández, Alba

    2015-01-01

    Highlights: • Repair ability under long-term exposure to arsenic was tested using the comet assay. • Effects were measured under Ogg1 wild-type and deficient backgrounds. • Exposed cells repair less efficiency the DNA damage induced by SA, KBrO 3 , MMA III or UVC radiation. • Oxidative damage and Ogg1 deficient background exacerbate repair deficiencies. • Overexpression of the arsenic metabolizing enzyme As3mt acts as adaptive mechanism. - Abstract: Inorganic arsenic (i-As) is a genotoxic and carcinogenic environmental contaminant known to affect millions of people worldwide. Our previous work demonstrated that chronic sub-toxic i-As concentrations were able to induce biologically significant levels of genotoxic and oxidative DNA damage that were strongly influenced by the Ogg1 genotype. In order to study the nature of the observed levels of damage and the observed differences between MEF Ogg1 +/+ and Ogg1 −/− genetic backgrounds, the genotoxic and oxidative DNA repair kinetics of 18-weeks exposed MEF cells were evaluated by the comet assay. Results indicate that MEF Ogg1 +/+ and Ogg1 −/− cells chronically exposed to i-As repair the DNA damage induced by arsenite, potassium bromide and UVC radiation less efficiently than control cells, being that observation clearly more pronounced in MEF Ogg1 −/− cells. Consequently, exposed cells accumulate a higher percentage of unrepaired DNA damage at the end of the repair period. As an attempt to eliminate i-As associated toxicity, chronically exposed MEF Ogg1 −/− cells overexpress the arsenic metabolizing enzyme As3mt. This adaptive response confers cells a significant resistance to i-As-induced cell death, but at expenses of accumulating high levels of DNA damage due to their repair impairment. Overall, the work presented here evidences that i-As chronic exposure disrupts the normal cellular repair function, and that oxidative DNA damage—and Ogg1 deficiency—exacerbates this phenomenon. The

  5. Estradiol and endocrine disrupting compounds adversely affect development of sea urchin embryos at environmentally relevant concentrations

    International Nuclear Information System (INIS)

    Roepke, Troy A.; Snyder, Mark J.; Cherr, Gary N.

    2005-01-01

    Environmental endocrine disrupting compounds (EDCs) are a wide variety of chemicals that typically exert effects, either directly or indirectly, through receptor-mediated processes, thus mimicking endogenous hormones and/or inhibiting normal hormone activities and metabolism. Little is known about the effects of EDCs on echinoderm physiology, reproduction and development. We exposed developing sea urchin embryos (Strongylocentrotus purpuratus and Lytechinus anamesus) to two known EDCs (4-octylphenol (OCT), bisphenol A (BisA)) and to natural and synthetic reproductive hormones (17β-estradiol (E 2 ), estrone (E 1 ), estriol (E 3 ), progesterone (P 4 ) and 17α-ethynylestradiol (EE 2 )). In addition, we studied two non-estrogenic EDCs, tributyltin (TBT) and o,p-DDD. Successful development to the pluteus larval stage (96 h post-fertilization) was used to define EDC concentration-response relationships. The order of compound potency based on EC 50 values for a reduction in normal development was as follows: TBT L.anamesus > OCT > TBT S. p urpuratus >> E 2 > EE 2 > DDD >> BisA > P 4 > E 1 >> E 3 . The effect of TBT was pronounced even at concentrations substantially lower than those commonly reported in heavily contaminated areas, but the response was significantly different in the two model species. Sea urchin embryos were generally more sensitive to estrogenic EDCs and TBT than most other invertebrate larvae. Stage-specific exposure experiments were conducted to determine the most sensitive developmental periods using blastula, gastrula and post-gastrula (pluteus) stages. The stage most sensitive to E 2 , OCT and TBT was the blastula stage with less overall sensitivity in the gastrula stage, regardless of concentration. Selective estrogen receptor modulators (SERMs) were added to the experiments individually and in combination with estrogenic EDCs to interfere with potential receptor-mediated actions. Tamoxifen, a partial ER agonist, alone inhibited development at

  6. Reduced cellular DNA repair capacity after environmentally relevant arsenic exposure. Influence of Ogg1 deficiency

    Energy Technology Data Exchange (ETDEWEB)

    Bach, Jordi; Peremartí, Jana; Annangi, Balasubramnayam [Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona (Spain); Marcos, Ricard, E-mail: ricard.marcos@uab.es [Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona (Spain); CIBER Epidemiología y Salud Pública, ISCIII, Madrid (Spain); Hernández, Alba, E-mail: alba.hernandez@uab.es [Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona (Spain); CIBER Epidemiología y Salud Pública, ISCIII, Madrid (Spain)

    2015-09-15

    Highlights: • Repair ability under long-term exposure to arsenic was tested using the comet assay. • Effects were measured under Ogg1 wild-type and deficient backgrounds. • Exposed cells repair less efficiency the DNA damage induced by SA, KBrO{sub 3}, MMA{sup III} or UVC radiation. • Oxidative damage and Ogg1 deficient background exacerbate repair deficiencies. • Overexpression of the arsenic metabolizing enzyme As3mt acts as adaptive mechanism. - Abstract: Inorganic arsenic (i-As) is a genotoxic and carcinogenic environmental contaminant known to affect millions of people worldwide. Our previous work demonstrated that chronic sub-toxic i-As concentrations were able to induce biologically significant levels of genotoxic and oxidative DNA damage that were strongly influenced by the Ogg1 genotype. In order to study the nature of the observed levels of damage and the observed differences between MEF Ogg1{sup +/+} and Ogg1{sup −/−} genetic backgrounds, the genotoxic and oxidative DNA repair kinetics of 18-weeks exposed MEF cells were evaluated by the comet assay. Results indicate that MEF Ogg1{sup +/+} and Ogg1{sup −/−} cells chronically exposed to i-As repair the DNA damage induced by arsenite, potassium bromide and UVC radiation less efficiently than control cells, being that observation clearly more pronounced in MEF Ogg1{sup −/−} cells. Consequently, exposed cells accumulate a higher percentage of unrepaired DNA damage at the end of the repair period. As an attempt to eliminate i-As associated toxicity, chronically exposed MEF Ogg1{sup −/−} cells overexpress the arsenic metabolizing enzyme As3mt. This adaptive response confers cells a significant resistance to i-As-induced cell death, but at expenses of accumulating high levels of DNA damage due to their repair impairment. Overall, the work presented here evidences that i-As chronic exposure disrupts the normal cellular repair function, and that oxidative DNA damage—and Ogg1 deficiency

  7. Bio-environmental factors associated with myopia: An updated review.

    Science.gov (United States)

    Galvis, V; Tello, A; Camacho, P A; Parra, M M; Merayo-Lloves, J

    2017-07-01

    Experimental studies in animals, as well as observational and intervention studies in humans, seem to support the premise that the development of juvenile myopia is promoted by a combination of the effect of genetic and environmental factors, with a complex interaction between them. The very rapid increase in myopia rates in some parts of the world, such as Southeast Asia, supports a significant environmental effect. Several lines of evidence suggest that humans might respond to various external factors, such as increased activity in near vision, increased educational pressure, decreased exposure to sunlight outdoors, dietary changes (including increased intake of carbohydrates), as well as low light levels indoors. All these factors could be associated with a higher prevalence of myopia. Copyright © 2017 Sociedad Española de Oftalmología. Publicado por Elsevier España, S.L.U. All rights reserved.

  8. Environmental factors in causing human cancers: emphasis on tumorigenesis.

    Science.gov (United States)

    Sankpal, Umesh T; Pius, Hima; Khan, Moeez; Shukoor, Mohammed I; Maliakal, Pius; Lee, Chris M; Abdelrahim, Maen; Connelly, Sarah F; Basha, Riyaz

    2012-10-01

    The environment and dietary factors play an essential role in the etiology of cancer. Environmental component is implicated in ~80 % of all cancers; however, the causes for certain cancers are still unknown. The potential players associated with various cancers include chemicals, heavy metals, diet, radiation, and smoking. Lifestyle habits such as smoking and alcohol consumption, exposure to certain chemicals (e.g., polycyclic aromatic hydrocarbons, organochlorines), metals and pesticides also pose risk in causing human cancers. Several studies indicated a strong association of lung cancer with the exposure to tobacco products and asbestos. The contribution of excessive sunlight, radiation, occupational exposure (e.g., painting, coal, and certain metals) is also well established in cancer. Smoking, excessive alcohol intake, consumption of an unhealthy diet, and lack of physical activity can act as risk factors for cancer and also impact the prognosis. Even though the environmental disposition is linked to cancer, the level and duration of carcinogen-exposure and associated cellular and biochemical aspects determine the actual risk. Modulations in metabolism and DNA adduct formation are considered central mechanisms in environmental carcinogenesis. This review describes the major environmental contributors in causing cancer with an emphasis on molecular aspects associated with environmental disposition in carcinogenesis.

  9. Assessment of health status of oysters (Crassostreagigas) exposed to environmentally relevant concentrations of Ag and Cu in brackish waters

    Science.gov (United States)

    Rementeria, Ane; Mikolaczyk, Mathilde; Peña, Ainhize; Lanceleur, Laurent; Blanc, Gérard; Soto, Manu; Schäfer, Jörg; Zaldibar, Beñat

    2017-12-01

    Human activities have altered estuarine environments leading to increased presence of different pollutants including metals. Although the implementation of new environmental policies has caused a considerable decrease in trace metal concentrations in estuaries around the Bay of Biscay, some elements such as copper (Cu) and silver (Ag) are still present in relatively high concentrations. Oysters have been widely used in environmental biomonitoring programs as sentinel organisms. Oysters Crassostrea gigas from an uncontaminated estuary were exposed to sublethal, environmentally relevant concentrations of Cu (2000 ng Cu/L) and Ag (500 ng Ag/L) during 14 days in brackish water (S = 18). A battery of cell and tissue level (exposure) biomarkers at different levels of biological complexity was applied and integrated into the Integrative Biological Response (IBR) index including: metallothionein contents, intralysosomal metal accumulation, digestive gland atrophy and digestive gland tissue integrity. Condition Index (CI) was incorporated into the IBR index as a complementary parameter that reflects the general physiological condition of oysters (organism level). Results indicated an increase in intralysosomal metal accumulation after 7 and 14 days of exposure to Ag together with an increase in the digestive epithelium atrophy and lipofuscin content after 7 days of exposure to Ag. The responses detected with the aid of biomarkers integrated in the IBR index showed higher toxicity in oysters exposed to Ag, inducing the clear onset of detoxification processes which also occurred, to a lower extent, in Cu-exposed oysters.

  10. Cadmium toxicity investigated at the physiological and biophysical levels under environmentally relevant conditions using the aquatic model plant Ceratophyllum demersum

    DEFF Research Database (Denmark)

    Andresen, Elisa; Kappel, Sophie; Stärk, Hans-Joachim

    2016-01-01

    Cadmium (Cd) is an important environmental pollutant and is poisonous to most organisms. We aimed to unravel the mechanisms of Cd toxicity in the model water plant Ceratophyllum demersum exposed to low (nM) concentrations of Cd as are present in nature. Experiments were conducted under environmen......Cadmium (Cd) is an important environmental pollutant and is poisonous to most organisms. We aimed to unravel the mechanisms of Cd toxicity in the model water plant Ceratophyllum demersum exposed to low (nM) concentrations of Cd as are present in nature. Experiments were conducted under...... environmentally relevant conditions, including nature-like light and temperature cycles, and a low biomass to water ratio. We measured chlorophyll (Chl) fluorescence kinetics, oxygen exchange, the concentrations of reactive oxygen species and pigments, metal binding to proteins, and the accumulation of starch...... and metals. The inhibition threshold concentration for most parameters was 20 nM. Below this concentration, hardly any stress symptoms were observed. The first site of inhibition was photosynthetic light reactions (the maximal quantum yield of photosystem II (PSII) reaction centre measured as Fv /Fm , light...

  11. Host and Environmental Factors Affecting the Intestinal Microbiota in Chickens.

    Science.gov (United States)

    Kers, Jannigje G; Velkers, Francisca C; Fischer, Egil A J; Hermes, Gerben D A; Stegeman, J A; Smidt, Hauke

    2018-01-01

    The initial development of intestinal microbiota in poultry plays an important role in production performance, overall health and resistance against microbial infections. Multiplexed sequencing of 16S ribosomal RNA gene amplicons is often used in studies, such as feed intervention or antimicrobial drug trials, to determine corresponding effects on the composition of intestinal microbiota. However, considerable variation of intestinal microbiota composition has been observed both within and across studies. Such variation may in part be attributed to technical factors, such as sampling procedures, sample storage, DNA extraction, the choice of PCR primers and corresponding region to be sequenced, and the sequencing platforms used. Furthermore, part of this variation in microbiota composition may also be explained by different host characteristics and environmental factors. To facilitate the improvement of design, reproducibility and interpretation of poultry microbiota studies, we have reviewed the literature on confounding factors influencing the observed intestinal microbiota in chickens. First, it has been identified that host-related factors, such as age, sex, and breed, have a large effect on intestinal microbiota. The diversity of chicken intestinal microbiota tends to increase most during the first weeks of life, and corresponding colonization patterns seem to differ between layer- and meat-type chickens. Second, it has been found that environmental factors, such as biosecurity level, housing, litter, feed access and climate also have an effect on the composition of the intestinal microbiota. As microbiota studies have to deal with many of these unknown or hidden host and environmental variables, the choice of study designs can have a great impact on study outcomes and interpretation of the data. Providing details on a broad range of host and environmental factors in articles and sequence data repositories is highly recommended. This creates opportunities to

  12. Host and Environmental Factors Affecting the Intestinal Microbiota in Chickens

    Directory of Open Access Journals (Sweden)

    Jannigje G. Kers

    2018-02-01

    Full Text Available The initial development of intestinal microbiota in poultry plays an important role in production performance, overall health and resistance against microbial infections. Multiplexed sequencing of 16S ribosomal RNA gene amplicons is often used in studies, such as feed intervention or antimicrobial drug trials, to determine corresponding effects on the composition of intestinal microbiota. However, considerable variation of intestinal microbiota composition has been observed both within and across studies. Such variation may in part be attributed to technical factors, such as sampling procedures, sample storage, DNA extraction, the choice of PCR primers and corresponding region to be sequenced, and the sequencing platforms used. Furthermore, part of this variation in microbiota composition may also be explained by different host characteristics and environmental factors. To facilitate the improvement of design, reproducibility and interpretation of poultry microbiota studies, we have reviewed the literature on confounding factors influencing the observed intestinal microbiota in chickens. First, it has been identified that host-related factors, such as age, sex, and breed, have a large effect on intestinal microbiota. The diversity of chicken intestinal microbiota tends to increase most during the first weeks of life, and corresponding colonization patterns seem to differ between layer- and meat-type chickens. Second, it has been found that environmental factors, such as biosecurity level, housing, litter, feed access and climate also have an effect on the composition of the intestinal microbiota. As microbiota studies have to deal with many of these unknown or hidden host and environmental variables, the choice of study designs can have a great impact on study outcomes and interpretation of the data. Providing details on a broad range of host and environmental factors in articles and sequence data repositories is highly recommended. This creates

  13. Estradiol and endocrine disrupting compounds adversely affect development of sea urchin embryos at environmentally relevant concentrations

    Energy Technology Data Exchange (ETDEWEB)

    Roepke, Troy A. [Bodega Marine Laboratory, University of California, Davis, POB 247, Bodega Bay, CA 94923 (United States); Snyder, Mark J. [Bodega Marine Laboratory, University of California, Davis, POB 247, Bodega Bay, CA 94923 (United States); Cherr, Gary N. [Bodega Marine Laboratory, University of California, Davis, POB 247, Bodega Bay, CA 94923 (United States) and Departments of Environmental Toxicology and Nutrition, One Shields Avenue, University of California, Davis, CA 95616 (United States)]. E-mail: gncherr@ucdavis.edu

    2005-01-26

    Environmental endocrine disrupting compounds (EDCs) are a wide variety of chemicals that typically exert effects, either directly or indirectly, through receptor-mediated processes, thus mimicking endogenous hormones and/or inhibiting normal hormone activities and metabolism. Little is known about the effects of EDCs on echinoderm physiology, reproduction and development. We exposed developing sea urchin embryos (Strongylocentrotus purpuratus and Lytechinus anamesus) to two known EDCs (4-octylphenol (OCT), bisphenol A (BisA)) and to natural and synthetic reproductive hormones (17{beta}-estradiol (E{sub 2}), estrone (E{sub 1}), estriol (E{sub 3}), progesterone (P{sub 4}) and 17{alpha}-ethynylestradiol (EE{sub 2})). In addition, we studied two non-estrogenic EDCs, tributyltin (TBT) and o,p-DDD. Successful development to the pluteus larval stage (96 h post-fertilization) was used to define EDC concentration-response relationships. The order of compound potency based on EC{sub 50} values for a reduction in normal development was as follows: TBT {sub L.anamesus} > OCT > TBT {sub S.{sub p}}{sub urpuratus} >> E{sub 2} > EE{sub 2} > DDD >> BisA > P{sub 4} > E{sub 1} >> E{sub 3}. The effect of TBT was pronounced even at concentrations substantially lower than those commonly reported in heavily contaminated areas, but the response was significantly different in the two model species. Sea urchin embryos were generally more sensitive to estrogenic EDCs and TBT than most other invertebrate larvae. Stage-specific exposure experiments were conducted to determine the most sensitive developmental periods using blastula, gastrula and post-gastrula (pluteus) stages. The stage most sensitive to E{sub 2}, OCT and TBT was the blastula stage with less overall sensitivity in the gastrula stage, regardless of concentration. Selective estrogen receptor modulators (SERMs) were added to the experiments individually and in combination with estrogenic EDCs to interfere with potential receptor

  14. Environmental risk factors for chronic pancreatitis and pancreatic cancer.

    Science.gov (United States)

    Nitsche, Claudia; Simon, Peter; Weiss, F Ulrich; Fluhr, Gabriele; Weber, Eckhard; Gärtner, Simone; Behn, Claas O; Kraft, Matthias; Ringel, Jörg; Aghdassi, Ali; Mayerle, Julia; Lerch, Markus M

    2011-01-01

    Chronic pancreatitis has long been thought to be mainly associated with immoderate alcohol consumption. The observation that only ∼10% of heavy drinkers develop chronic pancreatitis not only suggests that other environmental factors, such as tobacco smoke, are potent additional risk factors, but also that the genetic component of pancreatitis is more common than previously presumed. Either disease-causing or protective traits have been indentified for mutations in different trypsinogen genes, the gene for the trypsin inhibitor SPINK1, chymotrypsinogen C, and the cystic fibrosis transmembane conductance regulator (CFTR). Other factors that have been proposed to contribute to pancreatitis are obesity, diets high in animal protein and fat, as well as antioxidant deficiencies. For the development of pancreatic cancer, preexisting chronic pancreatitis, more prominently hereditary pancreatitis, is a risk factor. The data on environmental risk factors for pancreatic cancer are, with the notable exception of tobacco smoke, either sparse, unconfirmed or controversial. Obesity appears to increase the risk of pancreatic cancer in the West but not in Japan. Diets high in processed or red meat, diets low in fruits and vegetables, phytochemicals such as lycopene and flavonols, have been proposed and refuted as risk or protective factors in different trials. The best established and single most important risk factor for cancer as well as pancreatitis and the one to clearly avoid is tobacco smoke. Copyright © 2011 S. Karger AG, Basel.

  15. Environmental Factors and Zoonotic Pathogen Ecology in Urban Exploiter Species.

    Science.gov (United States)

    Rothenburger, Jamie L; Himsworth, Chelsea H; Nemeth, Nicole M; Pearl, David L; Jardine, Claire M

    2017-09-01

    Knowledge of pathogen ecology, including the impacts of environmental factors on pathogen and host dynamics, is essential for determining the risk that zoonotic pathogens pose to people. This review synthesizes the scientific literature on environmental factors that influence the ecology and epidemiology of zoonotic microparasites (bacteria, viruses and protozoa) in globally invasive urban exploiter wildlife species (i.e., rock doves [Columba livia domestica], European starlings [Sturnus vulgaris], house sparrows [Passer domesticus], Norway rats [Rattus norvegicus], black rats [R. rattus] and house mice [Mus musculus]). Pathogen ecology, including prevalence and pathogen characteristics, is influenced by geographical location, habitat, season and weather. The prevalence of zoonotic pathogens in mice and rats varies markedly over short geographical distances, but tends to be highest in ports, disadvantaged (e.g., low income) and residential areas. Future research should use epidemiological approaches, including random sampling and robust statistical analyses, to evaluate a range of biotic and abiotic environmental factors at spatial scales suitable for host home range sizes. Moving beyond descriptive studies to uncover the causal factors contributing to uneven pathogen distribution among wildlife hosts in urban environments may lead to targeted surveillance and intervention strategies. Application of this knowledge to urban maintenance and planning may reduce the potential impacts of urban wildlife-associated zoonotic diseases on people.

  16. Environmentally relevant concentrations of polyethylene microplastics negatively impact the survival, growth and emergence of sediment-dwelling invertebrates.

    Science.gov (United States)

    Ziajahromi, Shima; Kumar, Anupama; Neale, Peta A; Leusch, Frederic D L

    2018-05-01

    Microplastics are a widespread environmental pollutant in aquatic ecosystems and have the potential to eventually sink to the sediment, where they may pose a risk to sediment-dwelling organisms. While the impacts of exposure to microplastics have been widely reported for marine biota, the effects of microplastics on freshwater organisms at environmentally realistic concentrations are largely unknown, especially for benthic organisms. Here we examined the effects of a realistic concentration of polyethylene microplastics in sediment on the growth and emergence of a freshwater organism Chironomus tepperi. We also assessed the influence of microplastic size by exposing C. tepperi larvae to four different size ranges of polyethylene microplastics (1-4, 10-27, 43-54 and 100-126 μm). Exposure to an environmentally relevant concentration of microplastics, 500 particles/kg sediment , negatively affected the survival, growth (i.e. body length and head capsule) and emergence of C. tepperi. The observed effects were strongly dependent on microplastic size with exposure to particles in the size range of 10-27 μm inducing more pronounced effects. While growth and survival of C. tepperi were not affected by the larger microplastics (100-126 μm), a significant reduction in the number of emerged adults was observed after exposure to the largest microplastics, with the delayed emergence attributed to exposure to a stressor. While scanning electron microscopy showed a significant reduction in the size of the head capsule and antenna of C. tepperi exposed to microplastics in the 10-27 μm size range, no deformities to the external structure of the antenna and mouth parts in organisms exposed to the same size range of microplastics were observed. These results indicate that environmentally relevant concentrations of microplastics in sediment induce harmful effects on the development and emergence of C. tepperi, with effects greatly dependent on particle size. Copyright

  17. Psychosocial and environmental risk factors associated with mental disorders

    Directory of Open Access Journals (Sweden)

    Restrepo, Paula Andrea

    2010-06-01

    Full Text Available In Colombia, there are few studies on the association of psychosocial and environmental factors with the most prevalent mental disorders; such studies are important due to the context of violence, social insecurity, and job and economic instability in the country. The objective of this study was to identify the psychosocial and environmental risk factors for mental disorders, in users of psychological services in Colombia. The Mini International Neuropsychiatric Interview and a Questionnaire to evaluate the Axis-IV of the DSM-IV-TR were applied to 490 participants. The analysis comprised descriptive statistics and risk factors. As risk factors for depression, there were identified housing problems, access to health care services, problems related to the primary group, economics, problems of the social environment, and labor. For generalized anxiety, there were identified economic and education issues. For panic disorders, the risk factors were related to social environment, and for social phobia, the risk factors were problems in education, work and social environment

  18. Environmental Risk Factors in Psoriasis: The Point of View of the Nutritionist

    Directory of Open Access Journals (Sweden)

    Luigi Barrea

    2016-07-01

    Full Text Available Psoriasis is a common, chronic, immune-mediated skin disease with systemic pro-inflammatory activation, where both environmental and genetic factors contribute to its pathogenesis. Among the risk factors for psoriasis, evidence is accumulating that nutrition plays a major role, per se, in psoriasis pathogenesis. In particular, body weight, nutrition, and diet may exacerbate the clinical manifestations, or even trigger the disease. Understanding the epidemiological relationship between obesity and psoriasis is also important for delineating the risk profile for the obesity-related comorbidities commonly found among psoriatic patients. Moreover, obesity can affect both drug’s pharmacokinetics and pharmacodynamics. Additionally, the overall beneficial effects on the obesity-associated comorbidities, clinical recommendations to reduce weight and to adopt a healthy lifestyle could improve the psoriasis severity, particularly in those patients with moderate to severe disease, thus exerting additional therapeutic effects in the conventional treatment in obese patients with psoriasis. Education regarding modifiable environmental factors is essential in the treatment of this disease and represents one of the primary interventions that can affect the prognosis of patients with psoriasis. The goal is to make psoriatic patients and health care providers aware of beneficial dietary interventions. The aim of this review is to assess the relevance of the environmental factors as modifiable risk factors in psoriasis pathogenesis, with particular regard to the involvement of obesity and nutrition in the management of psoriasis, providing also specific nutrition recommendations.

  19. Impact of environmental factors on neglected emerging arboviral diseases.

    Directory of Open Access Journals (Sweden)

    Camila Lorenz

    2017-09-01

    Full Text Available Brazil is a tropical country that is largely covered by rainforests and other natural ecosystems, which provide ideal conditions for the existence of many arboviruses. However, few analyses have examined the associations between environmental factors and arboviral diseases. Thus, based on the hypothesis of correlation between environment and epidemiology, the proposals of this study were (1 to obtain the probability of occurrence of Oropouche, Mayaro, Saint Louis and Rocio fevers in Brazil based on environmental conditions corresponding to the periods of occurrence of the outbreaks; (2 to describe the macroclimatic scenario in Brazil in the last 50 years, evaluating if there was any detectable tendency to increase temperatures and (3 to model future expansion of those arboviruses in Brazil based on future temperature projections.Our model assessed seven environmental factors (annual rainfall, annual temperature, elevation, seasonality of temperature, seasonality of precipitation, thermal amplitude, and daytime temperature variation for their association with the occurrence of outbreaks in the last 50 years. Our results suggest that various environmental factors distinctly influence the distribution of each arbovirus, with temperature being the central determinant of disease distribution in all high-risk areas. These areas are subject to change, since the average temperature of some areas has increased significantly over the time.This is the first spatio-temporal study of the Oropouche, Mayaro, Saint Louis, and Rocio arboviruses, and our results indicate that they may become increasingly important public health problems in Brazil. Thus, next studies and control programs should include these diseases and also take into consideration key environmental elements.

  20. Tributyltin induces premature hatching and reduces locomotor activity in zebrafish (Danio rerio) embryos/larvae at environmentally relevant levels.

    Science.gov (United States)

    Liang, Xuefang; Souders, Christopher L; Zhang, Jiliang; Martyniuk, Christopher J

    2017-12-01

    Tributyltin (TBT) is an organotin compound that is the active ingredient of many biocides and antifouling agents. In addition to its well established role as an endocrine disruptor, TBT is also associated with adverse effects on the nervous system and behavior. In this study, zebrafish (Danio rerio) embryos were exposed to environmentally relevant concentrations of TBT (0.01, 0.1, 1 nM) to determine how low levels affected development and behavior. Fish exposed to 1 nM TBT hatched earlier when compared to controls. Following a 96-h exposure, total swimming distance, velocity, and activity of zebrafish larvae were reduced compared to controls. To identify putative mechanisms for these altered endpoints, we assessed embryo bioenergetics and gene expression. We reasoned that the accelerated hatch time could be related to ATP production and energy, thus embryos were exposed to TBT for 24 and 48-h exposure prior to hatch. There were no differences among groups for endpoints related to bioenergetics (i.e. basal, ATP-dependent, and maximal respiration). To address mechanisms related to changes in behavioral activity, we measured transcripts associated with muscle function (myf6, myoD, and myoG) and dopamine signaling (th, dat, dopamine receptors) as dopamine regulates behavior. No transcript was altered in expression by TBT in larvae, suggesting that other mechanisms exist that may explain changes in higher level endpoints. These results suggest that endpoints related to the whole animal (i.e. timing of hatch and locomotor behavior) are more sensitive to environmentally-relevant concentrations of TBT compared to the molecular and metabolic endpoints examined here. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Barrier-relevant crash modification factors and average costs of crashes on arterial roads in Indiana.

    Science.gov (United States)

    Zou, Yaotian; Tarko, Andrew P

    2018-02-01

    The objective of this study was to develop crash modification factors (CMFs) and estimate the average crash costs applicable to a wide range of road-barrier scenarios that involved three types of road barriers (concrete barriers, W-beam guardrails, and high-tension cable barriers) to produce a suitable basis for comparing barrier-oriented design alternatives and road improvements. The intention was to perform the most comprehensive and in-depth analysis allowed by the cross-sectional method and the crash data available in Indiana. To accomplish this objective and to use the available data efficiently, the effects of barrier were estimated on the frequency of barrier-relevant (BR) crashes, the types of harmful events and their occurrence during a BR crash, and the severity of BR crash outcomes. The harmful events component added depth to the analysis by connecting the crash onset with its outcome. Further improvement of the analysis was accomplished by considering the crash outcome severity of all the individuals involved in a crash and not just drivers, utilizing hospital data, and pairing the observations with and without road barriers along same or similar road segments to better control the unobserved heterogeneity. This study confirmed that the total number of BR crashes tended to be higher where medians had installed barriers, mainly due to collisions with barriers and, in some cases, with other vehicles after redirecting vehicles back to traffic. These undesirable effects of barriers were surpassed by the positive results of reducing cross-median crashes, rollover events, and collisions with roadside hazards. The average cost of a crash (unit cost) was reduced by 50% with cable barriers installed in medians wider than 50ft. A similar effect was concluded for concrete barriers and guardrails installed in medians narrower than 50ft. The studied roadside guardrails also reduced the unit cost by 20%-30%. Median cable barriers were found to be the most effective

  2. Environmental Factors and Natural Resource Stock: Atlantic Herring case

    Energy Technology Data Exchange (ETDEWEB)

    Cho, J.H. [Korea Maritime Institute, Seoul (Korea); John, M. Gate [University of Rhode Island, Kingston (United States)

    2001-12-01

    Atlantic herrings have held the important position as fish-baits in the marine ecosystem such as major baits in fishing lobsters. The Atlantic herring is sensitively influenced by the environmental factors of the marine ecosystem, such as the temperature of seawater, the amount of planktons, and the submarine deposit of the habitat. In the immature phase of herrings, especially, they are very sensitive of the low temperature of seawater. This study analyzes the correlation between two-year-old imported herring resources and the temperature of seawater, measured by a satellite. The area of measuring temperature is limited to the spawning ground of Atlantic herrings. As results of the analysis, the coefficient is 0.69, which means that the environmental factors should be very seriously considered in explaining the change of fishing resources. 12 refs., 4 figs., 1 tab.

  3. Genetic and environmental factors interact to influence anxiety.

    Science.gov (United States)

    Gross, Cornelius; Hen, René

    2004-01-01

    Both genetic and environmental factors influence normal anxiety traits as well as anxiety disorders. In addition it is becoming increasingly clear that these factors interact to produce specific anxiety-related behaviors. For example, in humans and in monkeys mutations in the gene encoding for the serotonin transporter result in increased anxiety in adult life when combined with a stressful environment during development. Another recent example comes from twin studies suggesting that a small hippocampus can be a predisposing condition that renders individuals susceptible to post traumatic stress disorder. Such examples illustrate how specific mutations leading to abnormal brain development may increase vulnerability to environmental insults which may in turn lead to specific anxiety disorders.

  4. Hydro-environmental factors and phytoplankton of the Atlantic ...

    African Journals Online (AJOL)

    Hydro-environmental factors and phytoplankton of the Atlantic Ocean, off the Light House Beach, Lagos, Nigeria. ... (28.37±1.88), pH (7.85±0.17), conductivity (44738.75±6262.76 μS/cm), total dissolved solids (29236.71±4273.30 mg/L), salinity (27.11±3.91 ‰), alkalinity (126.99±42.81 mg/L) and chloride (15056.

  5. Discerning environmental factors affecting current tree growth in Central Europe

    Czech Academy of Sciences Publication Activity Database

    Cienciala, E.; Russ, R.; Šantrůčková, H.; Altman, Jan; Kopáček, Jiří; Hůnová, I.; Štěpánek, Petr; Oulehle, Filip; Tumajer, J.; Stähl, G.

    2016-01-01

    Roč. 573, dec (2016), s. 541-554 ISSN 0048-9697 R&D Projects: GA ČR(CZ) GA14-12262S Institutional support: RVO:67179843 ; RVO:67985939 ; RVO:60077344 Keywords : Norway spruce * Environmental change * Drought * N-deposition * Managed forest * Tree increment Subject RIV: EH - Ecology, Behaviour; EF - Botanics (BU-J); GK - Forestry (BC-A) Impact factor: 4.900, year: 2016

  6. Genetic and environmental factors in experimental and human cancer

    Energy Technology Data Exchange (ETDEWEB)

    Takayama, S.; Takebe, H.; Gelboin, H.V.; MaChahon, B.; Matsushima, T.; Sugimura, T.

    1980-01-01

    Recently technological advances in assaying mutagenic principles have revealed that there are many mutagens in the environment, some of which might be carcinogenic to human beings. Other advances in genetics have shown that genetic factors might play an important role in the induction of cancer in human beings, e.g., the high incidence of skin cancers in patients with xeroderma pigmentosum. These proceedings deal with the relationships between genetic and environmental factors in carcinogenesis. The contributors cover mixed-function oxidases, pharmacogenetics, twin studies, DNA repair, immunology, and epidemiology.

  7. Behavior toxicity to Caenorhabditis elegans transferred to the progeny after exposure to sulfamethoxazole at environmentally relevant concentrations

    Institute of Scientific and Technical Information of China (English)

    Zhenyang Yu; Lei Jiang; Daqiang Yin

    2011-01-01

    Sulfamethoxazole (SMX) is one of the most common detected antibiotics in the environment. In order to study whether SMX can affect behavior and growth and whether these effects could be transferred to the progeny, Caenorhabditis elegans was exposed at environmentally relevant concentrations for 24, 48, 72 and 96 hr, respectively. After exposure, the exposed parent generation (Po) was measured for behavior and growth indicators, which were presented as percentage of controls (POC). Then their corresponding unexposed progeny (F1) was separated and measured for the same indicators. The lowest POC for Po after 96 hr-exposure at 100 mg/L were 37.8%, 12.7%, 45.8% and 70.1% for body bending frequency (BBF), reversal movement (RM), Omega turns (OT) and body length (BL), respectively. And F1 suffered defects with the lowest POC as 55.8%, 24.1%, 48.5% and 60.7% for BBF, RM, OT and BL, respectively. Defects in both Po and F1 showed a time- and concentration-dependent fashion and behavior indicators showed better sensitivity than growth indicator. The observed effects on F1 demonstrated the transferable properties of SMX. Defects of SMX at environmental concentrations suggested that it is necessary to perform further systematical studies on its ecological risk in actual conditions.

  8. Characteristics of the human body and other relevant factors in dose assessment

    International Nuclear Information System (INIS)

    Kawamura, H.; Ohmomo, Y.

    1990-03-01

    This issue is the collection of the papers presented at the 16th National Institute of Radiological Science Seminar on Environmental Research. The 18 of the presented papers are indexed individually. (J.P.N.)

  9. Enrofloxacin at environmentally relevant concentrations enhances uptake and toxicity of cadmium in the earthworm Eisenia fetida in farm soils

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yinsheng, E-mail: yinshengli@sjtu.edu.cn [School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240 (China); Tang, Hao; Hu, Yingxiu; Wang, Xiuhong; Ai, Xiaojie; Tang, Li [School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240 (China); Matthew, Cory [Institute of Agriculture & Environment, Massey University, Private Bag 11-222, Palmerston North 4442 (New Zealand); Cavanagh, Jo [Landcare Research, PO Box 40, Lincoln 7640 (New Zealand); Qiu, Jiangping [School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240 (China)

    2016-05-05

    Highlights: • Enrofloxacin (EF) and cadmium (Cd) were independently adsorbed in soils. • EF accelerated and increased Cd bioaccumulation in earthworms. • At high concentration EF (10 mg kg{sup −1}) was toxic to earthworms. • EF enhanced Cd induced oxidative stress, and increased burrowing and respiration. • EF did not affect the Cd induced increase in metallothionein in earthworms. - Abstract: Individual and combined effects of enrofloxacin (EF) and cadmium (Cd) on the earthworm Eisenia fetida at environmentally relevant concentrations were investigated. EF is a veterinary antibiotic; Cd is an impurity in phosphatic fertiliser. For both, residues may accumulate in farm soils. In laboratory tests, over 98% of spiked EF was adsorbed by farm soils, with a half-life >8 weeks. However, earthworms absorbed less than 20% of spiked EF. Earthworms in soil with EF concentration 10 mg kg{sup −1} soil experienced transient oxidative stress and exhibited reduced burrowing activity and respiration after an 8-week exposure; EF at 0.1 and 1.0 mg kg{sup −1} soil did not elicit toxicity symptoms. When both were added, Cd did not affect EF uptake, but each increment of spiked EF increased Cd bioaccumulation and associated oxidative stress of earthworms, and also caused decreased burrow length and CO{sub 2} production. However, metallothionein induction was not affected. The enhanced toxicity of Cd to earthworms in the presence of EF at low environmental concentrations may have implications for the health and reproductive success of earthworm populations and highlights the importance of understanding effects of antibiotic contamination of farm soils, and of awareness of environmental effects from interaction between multiple contaminants.

  10. Enrofloxacin at environmentally relevant concentrations enhances uptake and toxicity of cadmium in the earthworm Eisenia fetida in farm soils

    International Nuclear Information System (INIS)

    Li, Yinsheng; Tang, Hao; Hu, Yingxiu; Wang, Xiuhong; Ai, Xiaojie; Tang, Li; Matthew, Cory; Cavanagh, Jo; Qiu, Jiangping

    2016-01-01

    Highlights: • Enrofloxacin (EF) and cadmium (Cd) were independently adsorbed in soils. • EF accelerated and increased Cd bioaccumulation in earthworms. • At high concentration EF (10 mg kg"−"1) was toxic to earthworms. • EF enhanced Cd induced oxidative stress, and increased burrowing and respiration. • EF did not affect the Cd induced increase in metallothionein in earthworms. - Abstract: Individual and combined effects of enrofloxacin (EF) and cadmium (Cd) on the earthworm Eisenia fetida at environmentally relevant concentrations were investigated. EF is a veterinary antibiotic; Cd is an impurity in phosphatic fertiliser. For both, residues may accumulate in farm soils. In laboratory tests, over 98% of spiked EF was adsorbed by farm soils, with a half-life >8 weeks. However, earthworms absorbed less than 20% of spiked EF. Earthworms in soil with EF concentration 10 mg kg"−"1 soil experienced transient oxidative stress and exhibited reduced burrowing activity and respiration after an 8-week exposure; EF at 0.1 and 1.0 mg kg"−"1 soil did not elicit toxicity symptoms. When both were added, Cd did not affect EF uptake, but each increment of spiked EF increased Cd bioaccumulation and associated oxidative stress of earthworms, and also caused decreased burrow length and CO_2 production. However, metallothionein induction was not affected. The enhanced toxicity of Cd to earthworms in the presence of EF at low environmental concentrations may have implications for the health and reproductive success of earthworm populations and highlights the importance of understanding effects of antibiotic contamination of farm soils, and of awareness of environmental effects from interaction between multiple contaminants.

  11. Mercury speciation and distribution in a glacierized mountain environment and their relevance to environmental risks in the inland Tibetan Plateau.

    Science.gov (United States)

    Sun, Xuejun; Zhang, Qianggong; Kang, Shichang; Guo, Junming; Li, Xiaofei; Yu, Zhengliang; Zhang, Guoshuai; Qu, Dongmei; Huang, Jie; Cong, Zhiyuan; Wu, Guangjian

    2018-08-01

    Glacierized mountain environments can preserve and release mercury (Hg) and play an important role in regional Hg biogeochemical cycling. However, the behavior of Hg in glacierized mountain environments and its environmental risks remain poorly constrained. In this research, glacier meltwater, runoff and wetland water were sampled in Zhadang-Qugaqie basin (ZQB), a typical glacierized mountain environment in the inland Tibetan Plateau, to investigate Hg distribution and its relevance to environmental risks. The total mercury (THg) concentrations ranged from 0.82 to 6.98ng·L -1 , and non-parametric pairwise multiple comparisons of the THg concentrations among the three different water samples showed that the THg concentrations were comparable. The total methylmercury (TMeHg) concentrations ranged from 0.041 to 0.115ng·L -1 , and non-parametric pairwise multiple comparisons of the TMeHg concentrations showed a significant difference. Both the THg and MeHg concentrations of water samples from the ZQB were comparable to those of other remote areas, indicating that Hg concentrations in the ZQB watershed are equivalent to the global background level. Particulate Hg was the predominant form of Hg in all runoff samples, and was significantly correlated with the total suspended particle (TSP) and not correlated with the dissolved organic carbon (DOC) concentration. The distribution of mercury in the wetland water differed from that of the other water samples. THg exhibited a significant correlation with DOC as well as TMeHg, whereas neither THg nor TMeHg was associated with TSP. Based on the above findings and the results from previous work, we propose a conceptual model illustrating the four Hg distribution zones in glacierized environments. We highlight that wetlands may enhance the potential hazards of Hg released from melting glaciers, making them a vital zone for investigating the environmental effects of Hg in glacierized environments and beyond. Copyright © 2018

  12. Factors that Influence the Perceived Advantages and Relevance of Facebook as a Learning Tool: An Extension of the UTAUT

    Science.gov (United States)

    Escobar-Rodríguez, Tomás; Carvajal-Trujillo, Elena; Monge-Lozano, Pedro

    2014-01-01

    Social media technologies are becoming a fundamental component of education. This study extends the Unified Theory of Acceptance and Use of Technology (UTAUT) to identify factors that influence the perceived advantages and relevance of Facebook as a learning tool. The proposed model is based on previous models of UTAUT. Constructs from previous…

  13. The Relevance of Cultural Factors in Predicting Condom-Use Intentions among Immigrants from the Netherlands Antilles

    Science.gov (United States)

    Kocken, P. L.; van Dorst, A. G.; Schaalma, H.

    2006-01-01

    A study into the relevance of cultural factors in predicting condom-use intentions among Antillean migrants in the Netherlands is described in this article. The association between the intention to use condoms with a new sexual partner and a perceived taboo on discussing sex, beliefs about sex education and machismo beliefs on gender and power…

  14. The relevance of cultural factors in predicting condom-use intentions among immigrants from the Netherlands Antilles

    NARCIS (Netherlands)

    Kocken, P.L.; Dorst, A.G. van; Schaalma, H.

    2006-01-01

    A study into the relevance of cultural factors in predicting condom-use intentions among Antillean migrants in the Netherlands is described in this article. The association between the intention to use condoms with a new sexual partner and a perceived taboo on discussing sex, beliefs about sex

  15. The impact of environmental factors on traffic accidents in Iran.

    Science.gov (United States)

    Lankarani, Kamran B; Heydari, Seyed Taghi; Aghabeigi, Mohammad Reza; Moafian, Ghasem; Hoseinzadeh, Amin; Vossoughi, Mehrdad

    2014-07-01

    Road traffic crashes are the third highest cause of mortality in Iran. The aim of this study was to determine the impact of roadway environmental factors on traffic crash. This cross-sectional study was conducted in Iran between March 21, 2010 and December 30, 2010. The data on road traffic crashes were obtained from the Traffic Police Department records. These records were classified to control for the main confounders related to the type of crash and roadway environmental factors. Roadway environmental factors included crash scene light, weather, place of accident, the defects and geometrics of roadway and road surface. The study included 542,863 traffic crashes. The proportions of road traffic crash which led to injury were 24.44% at sunrise and 27.16% at sunset compared with 5.43% and 1.43% deaths at sunrise and sunset respectively. In regard to day time accidents, the proportions were 20.50% injuries and 0.55% deaths. The statistical analysis of the results showed that the ratio of injuries and deaths were significantly higher at sunrise and sunset than those occurring during daytime (P less than 0.001). The highest rate of death (5.07%) was due to dusty weather compared to 5.07% for other weather conditions (P less than 0.001). The highest mortality rate (3.45%) occurred on oily surfaces (P less than 0.001). The defective traffic signs were responsible for 30,046 injuries and 5.58% deaths, and road narrowing accounted for 22,775 injuries and, 4.23% deaths which indicated that the roadway defects inflict most frequent injuries and deaths. The lowest (0.74 %) and highest (3.09%) proportion of traffic crash- related deaths were due to flat straight and winding uphill/downhill roads respectively (P less than 0.001). Sunrise, sunset, dusty weather, oily road surfaces and winding uphill/downhill road were hazardous environmental factors. This study provides an insight into the potential impacts of environmental factors on road traffic accidents and underlines the

  16. Hapiness and Environmental Awareness – Factors of Sustainable Development

    Directory of Open Access Journals (Sweden)

    Anita Frajman Jakšić

    2010-12-01

    Full Text Available Economic growth was long perceived as the key goal of economic development. But as the capitalist economies got richer and as negative consequences of the growth spurt became more obvious, the development paradigm began to change course towards sustainability, which encompasses economic, environmental and social dimensions. The purpose of the article is to link the value system in the society and the possibility of the society to embrace the sustainable development model. We first provide the theoretical framework, followed by an empirical analysis of Croatia. The stress is on the environmental component of sustainability. The article builds from the popular stream of economic theory, i.e. economic analysis of happiness, which claims that happiness results not solely from economic factors, but also personal and broader social elements. These can also include environmental variables. In economic analysis of happiness, the consumer is not a standard utility maximizing consumer, who directly links utility and consumption of goods. His happiness is largely determined also by environmental elements. The existence of such consumers is consequently a prerequisite for the establishment of the sustainable economy. Empirical results show that: (1 consumers in general are at the moment not well educated about ecological problems, but (2 those that are give a lot of attention to environmental aspects. It is also important to note that future sustainability depends primarily on the attitude of current young cohorts (15 to 24 years, which, unfortunately, are least environmentally conscious. The role of the government and public institutions in preparing broader educational campaigns can therefore be significant.

  17. An epidemiological study of environmental factors associated with canine obesity.

    Science.gov (United States)

    Courcier, E A; Thomson, R M; Mellor, D J; Yam, P S

    2010-07-01

    To assess the relationships between socioeconomic and other environmental factors with canine obesity. This was a cross-sectional questionnaire study of dog owners attending five primary veterinary practices in the UK. Owners were asked about dog age, neuter status, feeding habits, dog exercise, household income and owner age. The body condition score of the dogs was also assessed. Factors hypothesised to be associated with obesity were investigated. In total, data from 696 questionnaires were evaluated. Out of those data evaluated, 35.3% of dogs (n=246) were classed as an ideal body shape, 38.9% (n=271) were overweight, 20.4% (n=142) were obese and 5.3% (n=37) were underweight. Identified risk factors associated with obesity included owner age, hours of weekly exercise, frequency of snacks/treats and personal income. Environmental risk factors associated with canine obesity are multifactorial and include personal income, owner age, frequency of snacks/treats and amount of exercise the dog receives. Awareness about health risks associated with obesity in dogs is significantly less in people in lower income brackets. This phenomenon is recognised in human obesity.

  18. Modeling impact of environmental factors on photovoltaic array performance

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Jie; Sun, Yize; Xu, Yang [College of Mechanical Engineering, Donghua University NO.2999, North Renmin Road, Shanghai (China)

    2013-07-01

    It is represented in this paper that a methodology to model and quantify the impact of the three environmental factors, the ambient temperature, the incident irradiance and the wind speed, upon the performance of photovoltaic array operating under outdoor conditions. First, A simple correlation correlating operating temperature with the three environmental variables is validated for a range of wind speed studied, 2-8, and for irradiance values between 200 and 1000. Root mean square error (RMSE) between modeled operating temperature and measured values is 1.19% and the mean bias error (MBE) is -0.09%. The environmental factors studied influence I-V curves, P-V curves, and maximum-power outputs of photovoltaic array. The cell-to-module-to-array mathematical model for photovoltaic panels is established in this paper and the method defined as segmented iteration is adopted to solve the I-V curve expression to relate model I-V curves. The model I-V curves and P-V curves are concluded to coincide well with measured data points. The RMSE between numerically calculated maximum-power outputs and experimentally measured ones is 0.2307%, while the MBE is 0.0183%. In addition, a multivariable non-linear regression equation is proposed to eliminate the difference between numerically calculated values and measured ones of maximum power outputs over the range of high ambient temperature and irradiance at noon and in the early afternoon. In conclusion, the proposed method is reasonably simple and accurate.

  19. Environmental factors influencing the development and spread of antibiotic resistance.

    Science.gov (United States)

    Bengtsson-Palme, Johan; Kristiansson, Erik; Larsson, D G Joakim

    2018-01-01

    Antibiotic resistance and its wider implications present us with a growing healthcare crisis. Recent research points to the environment as an important component for the transmission of resistant bacteria and in the emergence of resistant pathogens. However, a deeper understanding of the evolutionary and ecological processes that lead to clinical appearance of resistance genes is still lacking, as is knowledge of environmental dispersal barriers. This calls for better models of how resistance genes evolve, are mobilized, transferred and disseminated in the environment. Here, we attempt to define the ecological and evolutionary environmental factors that contribute to resistance development and transmission. Although mobilization of resistance genes likely occurs continuously, the great majority of such genetic events do not lead to the establishment of novel resistance factors in bacterial populations, unless there is a selection pressure for maintaining them or their fitness costs are negligible. To enable preventative measures it is therefore critical to investigate under what conditions and to what extent environmental selection for resistance takes place. In addition, understanding dispersal barriers is not only key to evaluate risks, but also to prevent resistant pathogens, as well as novel resistance genes, from reaching humans. © FEMS 2017.

  20. Effective Factors in Environmental Health Status of Grocery Stores

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    Mehdi Asadi

    2012-08-01

    Full Text Available Aims of the Study: This study was carried out to determine the effective factors in environmental health status of grocery stores in the city of Qom (located in the center of Iran. Materials & Methods: In this cross-sectional study, 283 grocery stores from 3 different regions were selected randomly using stratified sampling. Data were gathered through observation, interview, and questionnaire. The questionnaire consisted of two sections: section 1 dealt with some shop managers’ features including the age, educational level, job satisfaction, passing “food and occupational hygiene training courses”, store ownership, duration of employment, and features of stores including their location (Region and environmental health condition. And section 2 dealt with the important aspects of regulations of Article 13. The data analyzed using statistical procedures such as Spearman Rank Correlation and Multivariate Regression Analysis. P-values less than 0.05 were considered as statistically significant. Results: Among the investigated factors, the manager’s educational level had a greater impact on the environmental health conditions of grocery stores. The ownership status of grocery stores, Job satisfaction and passing “food and occupational hygiene training courses” were next in the ranking, respectively (p <0.001 for all measures, except for shop ownership, for which p-value was <0.02. Conclusions: Planning and implementation of effective operational and strategic programs addressing the above mentioned issues seems to be necessary. Such programs will improve the health status of the stores over time.

  1. Environmental factors in the development of autism spectrum disorders.

    Science.gov (United States)

    Sealey, L A; Hughes, B W; Sriskanda, A N; Guest, J R; Gibson, A D; Johnson-Williams, L; Pace, D G; Bagasra, O

    2016-03-01

    Autism spectrum disorders (ASD) are highly heterogeneous developmental conditions characterized by deficits in social interaction, verbal and nonverbal communication, and obsessive/stereotyped patterns of behavior and repetitive movements. Social interaction impairments are the most characteristic deficits in ASD. There is also evidence of impoverished language and empathy, a profound inability to use standard nonverbal behaviors (eye contact, affective expression) to regulate social interactions with others, difficulties in showing empathy, failure to share enjoyment, interests and achievements with others, and a lack of social and emotional reciprocity. In developed countries, it is now reported that 1%-1.5% of children have ASD, and in the US 2015 CDC reports that approximately one in 45 children suffer from ASD. Despite the intense research focus on ASD in the last decade, the underlying etiology remains unknown. Genetic research involving twins and family studies strongly supports a significant contribution of environmental factors in addition to genetic factors in ASD etiology. A comprehensive literature search has implicated several environmental factors associated with the development of ASD. These include pesticides, phthalates, polychlorinated biphenyls, solvents, air pollutants, fragrances, glyphosate and heavy metals, especially aluminum used in vaccines as adjuvant. Importantly, the majority of these toxicants are some of the most common ingredients in cosmetics and herbicides to which almost all of us are regularly exposed to in the form of fragrances, face makeup, cologne, air fresheners, food flavors, detergents, insecticides and herbicides. In this review we describe various scientific data to show the role of environmental factors in ASD. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Hemocytes of zebra mussels (Dreissena polymorpha are relevant cells for the monitoring of environmental genotoxicity by the comet assay.

    Directory of Open Access Journals (Sweden)

    Marc Bonnard

    2015-06-01

    Full Text Available The measure of DNA integrity by the single cell gel electrophoresis (SCGE or comet assay is especially recommended for its sensitivity and its capacity for detecting different types of damages. Therefore, it has been applied in environmental genotoxicity in a variety of organisms. It appears today necessary to define both reference and threshold levels of DNA damage, for their application in in situ biomonitoring. However, little is known about the influence of both biological (sex, reproduction status or external (temperature… confounding factors on the measure of DNA damage by the comet assay. These variables need to be taken into account if the robustness of the assay is to be established (Jha, 2008. In the zebra mussel Dreissena polymorpha (recommended as a sentinel species in the evaluation of freshwater quality the measure of DNA damage by the comet assay is mainly performed on hemocytes, which are circulating cells involved in key physiological functions such as immunity, homeostasis, detoxication…. This communication will present and discuss results from an innovative study about the variability of the baseline level of DNA damage in hemocytes of mussels encaged for one year in the canal de l’Aisne à la Marne (Reims, according to their sex and their reproductive status. The sensitivity and the suitability of hemocytes in the evaluation of environmental genotoxicity will also be discussed, referring to observations during a 6 month-exposure of mussels in mesocosms to environmentally realistic concentrations of carbamazepine.

  3. Epidemiologic Tools to Study the Influence of Environmental Factors on Fecundity and Pregnancy-related Outcomes

    Science.gov (United States)

    Slama, Rémy; Ballester, Ferran; Casas, Maribel; Cordier, Sylvaine; Eggesbø, Merete; Iniguez, Carmen; Nieuwenhuijsen, Mark; Philippat, Claire; Rey, Sylvie; Vandentorren, Stéphanie; Vrijheid, Martine

    2014-01-01

    Adverse pregnancy outcomes entail a large health burden for the mother and offspring; a part of it might be avoided by better understanding the role of environmental factors in their etiology. Our aims were to review the assessment tools to characterize fecundity troubles and pregnancy-related outcomes in human populations and their sensitivity to environmental factors. For each outcome, we reviewed the possible study designs, main sources of bias, and their suggested cures. In terms of study design, for most pregnancy outcomes, cohorts with recruitment early during or even before pregnancy allow efficient characterization of pregnancy-related events, time-varying confounders, and in utero exposures that may impact birth outcomes and child health. Studies on congenital anomalies require specific designs, assessment of anomalies in medical pregnancy terminations, and, for congenital anomalies diagnosed postnatally, follow-up during several months after birth. Statistical analyses should take into account environmental exposures during the relevant time windows; survival models are an appropriate approach for fecundity, fetal loss, and gestational duration/preterm delivery. Analysis of gestational duration could distinguish pregnancies according to delivery induction (and possibly pregnancy-related conditions). In conclusion, careful design and analysis are required to better characterize environmental effects on human reproduction. PMID:24363355

  4. Discussion on the Relevant Factors of General Surgery Incision Infection and Prevention Methods

    Directory of Open Access Journals (Sweden)

    Jin Baotao

    2017-01-01

    Full Text Available There are many reasons that can lead to incision infection of general surgical patients. The main reasons include weight, age, body albumin level, surgical time, observation ward, etc. This paper analyzes the clinic data of patients with incision infection after general surgery based on clinic practice and study on the reasons that have impact on general surgical incision infection and gives relevant prevention countermeasures.

  5. Environmental factors and health information technology management strategy.

    Science.gov (United States)

    Menachemi, Nir; Shin, Dong Yeong; Ford, Eric W; Yu, Feliciano

    2011-01-01

    : Previous studies have provided theoretical and empirical evidence that environmental forces influence hospital strategy. : Rooted in resource dependence theory and the information uncertainty perspective, this study examined the relationship between environmental market characteristics and hospitals' selection of a health information technology (HIT) management strategy. : A cross-sectional design is used to analyze secondary data from the American Hospital Association Annual Survey, the Healthcare Information and Management Systems Society Analytics Database, and the Area Resource File. Univariate and multinomial logistic regression analyses are used. : Overall, 3,221 hospitals were studied, of which 60.9% pursed a single-vendor HIT management strategy, 28.9% pursued a best-of-suite strategy, and 10.2% used a best-of-breed strategy. Multivariate analyses controlling for hospital characteristics found that measures of environmental factors representing munificence, dynamism, and/or complexity were systematically associated with various hospital HIT management strategy use. Specifically, the number of generalist physicians per capita was positively associated with the single-vendor strategy (B = -5.64, p = .10). Hospitals in urban markets were more likely to pursue the best-of-suite strategy (B = 0.622, p < .001). Dynamism, measured as the number of managed care contracts for a given hospital, was negatively associated with the single-vendor strategy (B = 0.004, p = .049). Lastly, complexity, measured as market competition, was positively associated with the best-of-breed strategy (B = 0.623, p = .042). : By and large, environmental factors are associated with hospital HIT management strategies in mostly theoretically supported ways. Hospital leaders and policy makers interested in influencing the adoption of hospital HIT should consider how market conditions influence HIT management decisions as part of programs to promote meaningful use.

  6. Husband and wife with sarcoidosis: possible environmental factors involved

    Directory of Open Access Journals (Sweden)

    Leli Ilaria

    2013-01-01

    Full Text Available Abstract Sarcoidosis is a granulomatous multisystem disorder of unclear etiology that involves any organ, most commonly the lung and the lymph nodes. It is hypothesized that the disease derives from the interaction between single or multiple environmental factors and genetically determined host factors. Multiple potential etiologic agents for sarcoidosis have been proposed without any definitive demonstration of causality. We report the case of two patients, husband (57 years old and wife (55 years old, both suffering from sarcoidosis. They underwent a lymph node biopsy by mediastinoscopy which showed a “granulomatous epithelioid giant cell non-necrotising chronic lymphadenitis”. They had lived up to 3 years ago in the country in a farm, in contact with organic dusts, animals such as dogs, chickens, rabbits, pigeons; now they have lived since about 3 years in an urban area where there are numerous chemical industries and stone quarries. The aim of this case report was to focus on environmental factors that might be related to the pathogenesis of the sarcoidosis.

  7. Environmental risk factors of childhood asthma in urban centers.

    Science.gov (United States)

    Malveaux, F J; Fletcher-Vincent, S A

    1995-09-01

    Asthma morbidity and mortality are disproportionately high in urban centers, and minority children are especially vulnerable. Factors that contribute to this dilemma include inadequate preventive medical care for asthma management, inadequate asthma knowledge and management skills among children and their families, psychosocial factors, and environmental exposure to allergens or irritants. Living in substandard housing often constitutes excess exposure to indoor allergens and pollutants. Allergens associated with dust mites (DM) and cockroaches (CR) are probably important in both onset and worsening of asthma symptoms for children who are chronically exposed to these agents. Young children spend a great deal of time on or near the floor where these allergens are concentrated in dust. Of children (2 to 10 years of age) living in metropolitan Washington, DC, 60% were found to be sensitive to CR and 72% were allergic to DM. Exposure to tobacco smoke contributes to onset of asthma earlier in life and is a risk factor for asthma morbidity. Since disparity of asthma mortality and morbidity among minority children in urban centers is closely linked to socioeconomic status and poverty, measures to reduce exposure to environmental allergens and irritants and to eliminate barriers to access to health care are likely to have a major positive impact. Interventions for children in urban centers must focus on prevention of asthma symptoms and promotion of wellness.

  8. The Role of Environmental Factors in Digestive Cancer

    Directory of Open Access Journals (Sweden)

    Rene Lambert

    2016-01-01

    Full Text Available The risk of digestive cancer in each country is analyzed in cancer registries for Incidence and Mortality. Survival is estimated from registries with a correct follow-up. Estimated values of Incidence and Mortality, expressed as an age standardized rate (ASR for 100 000 persons, for all the population of a country are also found in the WHO-IARC database Globocan, recently edited for the year 2008. At each site of digestive tumors, the variations between countries, in cancer incidence, mortality and survival, depend on the resources and the global health status of the country. Indeed environmental causal factors linked to lifestyle may have an increasing or decreasing impact on the risk of cancer. Such factors are classified on 3 categories: 1- nutrition plays a determinant role in colorectal cancer with a higher risk in countries with more resources and more calories in the diet. 2- Toxic agents like alcohol and tobacco increase the risk at all sites of digestive cancer; their role is preponderant in esophageal cancer. Aflatoxin, a food contaminant in tropical, less developed countries, increases the risk of liver cancer. 3 – Infectious agents play a major role with the Bacteria H.pylori for stomach cancer over the world, and the Hepatitis virus B and C for liver cancer in less developed countries of Africa and Asia. The control of carcinogenic causal environmental factors is included in the primary prevention of digestive cancer.

  9. Musculoskeletal alterations associated factors physical and environmental in dental students.

    Science.gov (United States)

    Fals Martínez, Juntzo; González Martínez, Farith; Orozco Páez, Jennifer; Correal Castillo, Sandra Patricia; Pernett Gómez, Cindy Vanessa

    2012-12-01

    To describe the musculoskeletal disorders and association with physical and environmental in students of Dentistry. Cross sectional study. Simple random sampling was conducted obtaining a proportional sample of 182 students per semester. Collecting information from physical and environmental exposures related to different clinical practice and this was assessed by a structured survey questionnaire type. The valuation muscle was performed by visual analysis with Scan-test. To assess factors related to working position, the instrument was used RULA. For the analysis of the association were used odds ratios with confidence intervals of 95%. For the multivariate analysis using logistic regression. 58.2% of students had pain tenderness in upper trapezius and 45.6% in area cervical. Lateral movements in the cervical found pain in 35.7%, with the bending cervical 35.1% related to all these factors own dental practice and not to other factors external. The onset of muscle pain in this population is influenced by multiple variables, most of them, related to dental practice of students to interact with each other can trigger symptoms at neck and back.

  10. Transport and retention of biochar nanoparticles in a paddy soil under environmentally-relevant solution chemistry conditions.

    Science.gov (United States)

    Chen, Ming; Wang, Dengjun; Yang, Fan; Xu, Xiaoyun; Xu, Nan; Cao, Xinde

    2017-11-01

    Land application of biochar has been increasingly recommended as a powerful strategy for carbon sequestration and soil remediation. However, the biochar particles, especially those in the nanoscale range, may migrate or carry the inherent contaminants along the soil profile, posing a potential risk to the groundwater. This study investigated the transport and retention of wood chip-derived biochar nanoparticles (NPs) in water-saturated columns packed with a paddy soil. The environmentally-relevant soil solution chemistry including ionic strength (0.10-50 mM), electrolyte type (NaCl and CaCl 2 ), and natural organic matter (0-10 mg L -1 humic acid) were tested to elucidate their effects on the biochar NPs transport. Higher mobility of biochar NPs was observed in the soil at lower ionic strengths, with CaCl 2 electrolyte being more effective than NaCl in decreasing biochar NPs transport. The retained biochar NPs in NaCl was re-entrained (∼57.7%) upon lowering transient pore-water ionic strength, indicating that biochar NPs were reversibly retained in the secondary minimum. In contrast, negligible re-entrainment of biochar NPs occurred in CaCl 2 due to the primary minimum and/or particle aggregation. Humic acid increased the mobility of biochar NPs, likely due to enhanced electrosteric repulsive interactions. The transport behaviors of biochar NPs can be well interpreted by a two-site kinetic retention model that assumes reversible retention for one site, and irreversible retention for the other site. Our findings indicated that the transport of wood chip biochar NPs is significant in the paddy soil, highlighting the importance of understanding the mobility of biochar NPs in natural soils for accurately assessing their environmental impacts. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. The progestin norethisterone affects thyroid hormone-dependent metamorphosis of Xenopus laevis tadpoles at environmentally relevant concentrations.

    Science.gov (United States)

    Lorenz, Claudia; Krüger, Angela; Schöning, Viola; Lutz, Ilka

    2018-04-15

    Previously, levonorgestrel (LNG) has been shown to be an endocrine disruptor of the amphibian thyroid system. In the present study, we investigated whether anti-thyroidal effects are a common property of progestins other than LNG. Premetamorphic Xenopus laevis tadpoles were exposed to norethisterone (NET) and dienogest DIE (each at 0.1-10nM) and LNG (10nM) until completion of metamorphosis. LNG and NET at all concentrations caused a significant developmental retardation whereas DIE did not impair time to metamorphosis. In LNG and 10nM NET exposed animals, tsh mRNA levels increased considerably later than the developmental delay occurred and thyroid histopathology showed no signs of TSH-hyperstimulation. Instead, thyroid glands from these treatments appeared inactive in producing thyroid hormones. Thyroidal transcript levels of dio2 and dio3 were increased by treatments with LNG and NET at 1nM and 10nM, whereas iyd mRNA was reduced by LNG and 10nM NET. Expression of slc5α5 was not changed by any treatment. Effects of DIE differed from those induced by LNG and NET. No developmental delay was measurable; however, tshβ and dio2 mRNAs were increased in pituitary glands of tadpoles exposed to 1.0nM and 10nM DIE. Thyroid histopathology displayed no abnormalities and thyroidal mRNA expression of the genes analyzed (slc5α5, iyd, dio2, dio3) was not changed by DIE. Overall, our results provide evidence that the anti-thyroidal effects already known from LNG are also present in another progestin, namely NET, even at environmentally relevant concentrations. In conclusion we suggest that progestins do not only pose an environmental risk in terms of their impact on reproductive success of aquatic vertebrates, but also with respect to their anti-thyroidal properties affecting amphibian metamorphosis. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Environmental factors prevail over dispersal constraints in determining the distribution and assembly of Trichoptera species in mountain lakes.

    Science.gov (United States)

    de Mendoza, Guillermo; Ventura, Marc; Catalan, Jordi

    2015-07-01

    Aiming to elucidate whether large-scale dispersal factors or environmental species sorting prevail in determining patterns of Trichoptera species composition in mountain lakes, we analyzed the distribution and assembly of the most common Trichoptera (Plectrocnemia laetabilis, Polycentropus flavomaculatus, Drusus rectus, Annitella pyrenaea, and Mystacides azurea) in the mountain lakes of the Pyrenees (Spain, France, Andorra) based on a survey of 82 lakes covering the geographical and environmental extremes of the lake district. Spatial autocorrelation in species composition was determined using Moran's eigenvector maps (MEM). Redundancy analysis (RDA) was applied to explore the influence of MEM variables and in-lake, and catchment environmental variables on Trichoptera assemblages. Variance partitioning analysis (partial RDA) revealed the fraction of species composition variation that could be attributed uniquely to either environmental variability or MEM variables. Finally, the distribution of individual species was analyzed in relation to specific environmental factors using binomial generalized linear models (GLM). Trichoptera assemblages showed spatial structure. However, the most relevant environmental variables in the RDA (i.e., temperature and woody vegetation in-lake catchments) were also related with spatial variables (i.e., altitude and longitude). Partial RDA revealed that the fraction of variation in species composition that was uniquely explained by environmental variability was larger than that uniquely explained by MEM variables. GLM results showed that the distribution of species with longitudinal bias is related to specific environmental factors with geographical trend. The environmental dependence found agrees with the particular traits of each species. We conclude that Trichoptera species distribution and composition in the lakes of the Pyrenees are governed predominantly by local environmental factors, rather than by dispersal constraints. For

  13. The role of environmental and lifestyle factors in the incidence and prevalence of cancer

    Directory of Open Access Journals (Sweden)

    Fatemeh Amereh

    2016-12-01

    Full Text Available  Background and purpose: Cancer is a noteworthy cause of morbidity and mortality worldwide, especially in developing countries. It is more often caused by the environment of a person lives in, rather than his or her innate biology. The highly significant and rapid changes in cancer incidence in the last decades are generally attributed to equally dramatic changes in population exposure to environmental factors. Methods: The available evidence on the role of environmental factors and their relevant effects in cancer rates has been studied. Results: Major of cancer risk factors are include tobacco, overweight and obesity, physical activity, diet and body composition, food, air and water contamination, and viral chronic infections. Exposure assessment and research methodology has been the Achilles heel for studies on environmental contaminants and cancer. Thus, it should not be looked at cancer merely as a disease, since cancer is beyond a disease and must be considered through different aspects. Conclusion: The scientific community effort to increase public awareness, winning the support of policy makers as well as intersectoral coordination in order to lifestyle modifications, reducing high-risk behaviors and confronting food, air and water contamination have strategic importance in cancer prevention. Basic and clinical studies as well as interdisciplinary research thence are necessary for a better understanding of the pathophysiology and finding more effective and cheaper ways to prevent, early diagnosis and treatment of cancer. Accordingly, this requires the investment of governmental and non-governmental democrats. 

  14. ENVIRONMENTAL FACTORS AFFECTING RACING TIME OF TROTTER HORSES IN SERBIA

    Directory of Open Access Journals (Sweden)

    Ljuba Štrbac

    2015-09-01

    Full Text Available Speed, the most important trait in trotter horses, forms the basis for examining their racing ability, and is calculated according to the time it takes to run a certain distance. The phenotypic manifestation of a horse’s speed is controlled by numerous genes and larger or smaller impacts of environmental factors. To improve trotter horse selection to be more successful and faster in genetic progress it is very important to determine the impacts of such gene-related and environmental factors. The aim of this study was to investigate the effect of year and month of birth, sex, year and season of race, age, racetrack, distance and type of start on trotter horse racing times. Data from the Association for Trotting Sport of Serbia (UKSS for the registered horses and races in the period from 1998 to 2010 were used. The database is comprised of data for 1263 horses over a total of 14398 races. After calculating descriptive statistics of racing times, the effect of fixed factors using the general linear model (GLM was examined. The average racing time achieved was 84.21s, and ranged from 73.8 to 132.2s. All of the tested factors had a statistically significant effect on the observed racing times. Thus, each of these factors should be included in future models for genetic prediction of the suitability of animals use as parents of further generations of racing trotters. This should increase the rate of genetic progress and competitiveness of the animals at both national and international levels.

  15. Geoepidemiology, Genetic and Environmental Risk Factors for PBC.

    Science.gov (United States)

    Zhang, Haiyan; Carbone, Marco; Lleo, Ana; Invernizzi, Pietro

    2015-01-01

    Primary biliary cirrhosis (PBC) is the most paradigmatic autoimmune liver disease with still several controversial issues in epidemiology, diagnosis, causation, and therapy. Although we are witnessing an enormous increase in the quantum of our basic knowledge of the disease with an initial translation in clinical practice, there are still a number of key open questions in PBC. Among them are the following questions: Why are there vast geographical variations in disease frequency? What are the reasons for female preponderance? Why do only small-size bile ducts get affected: What is the real role of genetics and epigenetics in its development? In particular, the prevalence of PBC is known to vary both on an international and a regional level, suggesting the existence of substantive geographical differences in terms of genetic susceptibility and environmental factors. New theories on potential environmental triggers, such as chemical xenobiotics, which lead to the breaking of self-tolerance within a unique immunological milieu of the liver, have been suggested. On the other hand, new and solid data on the genetic architecture of PBC are now obtained from recent high-throughput studies, together with data on sex chromosomes defects, and epigenetic abnormalities, thus strongly suggesting a role of genetic and epigenetic factors in the triggering and perpetuation of the autoimmune aggression in PBC. Based on these evidences, a number of novel drugs directed against specific immune-related molecules are currently under development. In this paper, we review a comprehensive collection of current epidemiological reports from various world regions. We also discuss here the most recent data regarding candidate genetic and environmental risk factors for PBC. © 2015 S. Karger AG, Basel.

  16. Genetic and environmental risk factors in adolescent substance use.

    Science.gov (United States)

    Silberg, Judy; Rutter, Michael; D'Onofrio, Brian; Eaves, Lindon

    2003-07-01

    The present study was undertaken with the goal of understanding the causes of association between substance use and both conduct disturbance (CD) and depression in adolescent boys and girls. Multivariate genetic structural equation models were fitted to multi-informant, multi-wave, longitudinal data collected in extensive home interviews with parents and children with respect to 307 MZ male, 392 MZ female, 185 DZ male, and 187 DZ female, same-sex twin pairs aged 12-17 years from the Virginia Twin Study of Adolescent Behavioral Development (VTSABD). Although conduct disturbance and depression were moderately associated with substance use, the pattern of genetic and environmental risk differed for males and females and across the two disorders. Genetic factors were predominant in girls' substance use whereas boys' use was mediated primarily by shared environmental factors reflecting family dysfunction and deviant peers. The patterns of correlations across the two waves of the study were consistent with conduct disturbance leading to substance use in both males and females, but depression leading to smoking, drug use and, to a lesser extent, alcohol use in girls. The comorbidity between substance use and depression, and between substance use and conduct disturbance in childhood/adolescence, probably reflects rather different mediating mechanisms--as well as a different time frame, with conduct disturbance preceding substance use but depression following it. In both, the co-occurrence partially reflected a shared liability but, in girls, genetic influences played an important role in the comorbidity involving depression, whereas in both sexes (but especially in boys) environmental factors played a substantial role. The extent to which these differences reflect genuine differences in the causal mechanisms underlying substance use and CD/depression in boys and girls revealed in the present analysis awaits replication from studies of other general population samples.

  17. The influence of environmental factors on bone tissue engineering.

    Science.gov (United States)

    Szpalski, Caroline; Sagebin, Fabio; Barbaro, Marissa; Warren, Stephen M

    2013-05-01

    Bone repair and regeneration are dynamic processes that involve a complex interplay between the substrate, local and systemic cells, and the milieu. Although each constituent plays an integral role in faithfully recreating the skeleton, investigators have long focused their efforts on scaffold materials and design, cytokine and hormone administration, and cell-based therapies. Only recently have the intangible aspects of the milieu received their due attention. In this review, we highlight the important influence of environmental factors on bone tissue engineering. Copyright © 2012 Wiley Periodicals, Inc.

  18. Breast cancer and personal environmental risk factors in Marin County - Pilot study

    Energy Technology Data Exchange (ETDEWEB)

    Erdmann, C.A.; Farren, G.; Baltzell, K.; Chew, T.; Clarkson, C.; Fleshman, R.; Leary, C.; Mizroch, M.; Orenstein, F.; Russell, M.L.; Souders-Mason, V.; Wrensch, M.

    2003-02-01

    The purpose of the Personal Environmental Risk Factor Study (PERFS) pilot project was to develop methodologies and a questionnaire for a future population-based case-control study to investigate the role of selected environmental exposures in breast cancer development. Identification of etiologically relevant exposures during a period of potential vulnerability proximate to disease onset offers the possibility of clinical disease prevention even when disease initiation may have already occurred many years earlier. Certain personal environmental agents or combinations of agents may influence disease promotion. Therefore, this pilot study focused on exposures that occurred during the ten-year period prior to diagnosis for cases and the last ten years for controls, rather than more historic exposures. For this pilot study, they used a community-based research approach. In the collaborative efforts, community members participated with academic researchers in all phases of the research, including research question identification, study design, development of research tools, development of the human subjects protocol, and report writing. Community member inclusion was based upon the concept that community participation could improve the relevance of scientific studies and ultimate success of the research by encouraging an ongoing dialogue between community members and academic representatives. Early activities of this project focused on the collection of input from the community regarding the possible role of environmental factors in the incidence of breast cancer in Marin County. The intent was to inform the scientists of community concerns, enhance the research team's understanding of the community being studied, and provide interested community members with a better understanding of the strengths and weaknesses of traditional research methods through active participation in the research process.

  19. Is the OECD acute worm toxicity test environmentally relevant? The effect of mineral form on calculated lead toxicity

    International Nuclear Information System (INIS)

    Davies, N.A.Nicola A.; Hodson, M.E.Mark E.; Black, S.Stuart

    2003-01-01

    The current OECD acute worm toxicity test does not relate well to ambient conditions. - In a series of experiments the toxicity of lead to worms in soil was determined following the draft OECD earthworm reproduction toxicity protocol except that lead was added as solid lead nitrate, carbonate and sulphide rather than as lead nitrate solution as would normally be the case. The compounds were added to the test soil to give lead concentrations of 625-12500 μg Pb g -1 of soil. Calculated toxicities of the lead decreased in the order nitrate>carbonate>sulphide, the same order as the decrease in the solubility of the metal compounds used. The 7-day LC 50 (lethal concentration when 50% of the population is killed) for the nitrate was 5321±275 μg Pb g -1 of soil and this did not change with time. The LC 50 values for carbonate and sulphide could not be determined at the concentration ranges used. The only parameter sensitive enough to distinguish the toxicities of the three compounds was cocoon (egg) production. The EC 50 s for cocoon production (the concentration to produce a 50% reduction in cocoon production) were 993, 8604 and 10246 μg Pb g -1 of soil for lead nitrate, carbonate and sulphide, respectively. Standard toxicity tests need to take into account the form in which the contaminant is present in the soil to be of environmental relevance

  20. Standardized toxicity testing may underestimate ecotoxicity: Environmentally relevant food rations increase the toxicity of silver nanoparticles to Daphnia.

    Science.gov (United States)

    Stevenson, Louise M; Krattenmaker, Katherine E; Johnson, Erica; Bowers, Alexandra J; Adeleye, Adeyemi S; McCauley, Edward; Nisbet, Roger M

    2017-11-01

    Daphnia in the natural environment experience fluctuations in algal food supply, with periods when algal populations bloom and seasons when Daphnia have very little algal food. Standardized chronic toxicity tests, used for ecological risk assessment, dictate that Daphnia must be fed up to 400 times more food than they would experience in the natural environment (outside of algal blooms) for a toxicity test to be valid. This disconnect can lead to underestimating the toxicity of a contaminant. We followed the growth, reproduction, and survival of Daphnia exposed to 75 and 200 µg/L silver nanoparticles (AgNPs) at 4 food rations for up to 99 d and found that AgNP exposure at low, environmentally relevant food rations increased the toxicity of AgNPs. Exposure to AgNP at low food rations decreased the survival and/or reproduction of individuals, with potential consequences for Daphnia populations (based on calculated specific population growth rates). We also found tentative evidence that a sublethal concentration of AgNPs (75 µg/L) caused Daphnia to alter energy allocation away from reproduction and toward survival and growth. The present findings emphasize the need to consider resource availability, and not just exposure, in the environment when estimating the effect of a toxicant. Environ Toxicol Chem 2017;36:3008-3018. © 2017 SETAC. © 2017 SETAC.

  1. Cork stoppers as an effective sorbent for water treatment: the removal of mercury at environmentally relevant concentrations and conditions.

    Science.gov (United States)

    Lopes, Cláudia B; Oliveira, Joana R; Rocha, Luciana S; Tavares, Daniela S; Silva, Carlos M; Silva, Susana P; Hartog, Niels; Duarte, Armando C; Pereira, E

    2014-02-01

    The technical feasibility of using stopper-derived cork as an effective biosorbent towards bivalent mercury at environmentally relevant concentrations and conditions was evaluated in this study. Only 25 mg/L of cork powder was able to achieve 94 % of mercury removal for an initial mercury concentration of 500 μg/L. It was found that under the conditions tested, the efficiency of mercury removal expressed as equilibrium removal percentage does not depend on the amount of cork or its particle size, but is very sensitive to initial metal concentration, with higher removal efficiencies at higher initial concentrations. Ion exchange was identified as one of the mechanisms involved in the sorption of Hg onto cork in the absence of ionic competition. Under ionic competition, stopper-derived cork showed to be extremely effective and selective for mercury in binary mixtures, while in complex matrices like seawater, moderate inhibition of the sorption process was observed, attributed to a change in mercury speciation. The loadings achieved are similar to the majority of literature values found for other biosorbents and for other metals, suggesting that cork stoppers can be recycled as an effective biosorbent for water treatment. However, the most interesting result is that equilibrium data show a very rare behaviour, with the isotherm presenting an almost square convex shape to the concentration axis, with an infinite slope for an Hg concentration in solution around 25 μg/L.

  2. Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma

    Directory of Open Access Journals (Sweden)

    Alison Maggioncalda

    2011-01-01

    Full Text Available Epidemiological studies suggest unique occurrence patterns of Hodgkin lymphoma (HL worldwide. In most Western countries there is a clear bimodal age distribution with an early peak in young adults followed by a second peak in older adults, particularly among males. In the Middle East and Asia, HL is more common in early childhood. There also are marked racial differences in the presentations of HL and HL subtypes, and particular single nucleotide polymorphisms (SNPs have been identified as etiological factors suggesting that gene-gene and gene-environment interactions are involved. Personal health choices such as exercise and smoking may modify an individual's chances of developing HL. Numerous studies highlight the impact that exposure to Epstein-Barr virus and other environmental factors have on HL risk. Understanding the relative importance of each of these findings and their links to HL development and survival will help clinical researchers expand curative therapies and create preventative strategies for HL.

  3. Environmental factors that influence cyanobacteria and geosmin occurrence in reservoirs

    Science.gov (United States)

    Journey, Celeste A.; Beaulieu, Karen M.; Bradley, Paul M.; Bradley, Paul M.

    2013-01-01

    Phytoplankton are small to microscopic, free-floating algae that inhabit the open water of freshwater, estuarine, and saltwater systems. In freshwater lake and reservoirs systems, which are the focus of this chapter, phytoplankton communities commonly consist of assemblages of the major taxonomic groups, including green algae, diatoms, dinoflagellates, and cyanobacteria. Cyanobacteria are a diverse group of single-celled organisms that can exist in a wide range of environments, not just open water, because of their adaptability. It is the adaptability of cyanobacteria that enables this group to dominate the phytoplankton community and even form nuisance or harmful blooms under certain environmental conditions. In fact, cyanobacteria are predicted to adapt favorably to future climate change in freshwater systems compared to other phytoplankton groups because of their tolerance to rising temperatures, enhanced vertical thermal stratification of aquatic ecosystems, and alterations in seasonal and interannual weather patterns. Understanding those environmental conditions that favor cyanobacterial dominance and bloom formation has been the focus of research throughout the world because of the concomitant production and release of nuisance and toxic cyanobacterial-derived compounds. However, the complex interaction among the physical, chemical, and biological processes within lakes, reservoirs, and large rivers often makes it difficult to identify primary environmental factors that cause the production and release of these cyanobacterial by-products.

  4. Social and environmental factors modulate leucocyte profiles in free-living Greylag geese (Anser anser

    Directory of Open Access Journals (Sweden)

    Didone Frigerio

    2017-01-01

    Full Text Available Background Blood parameters such as haematocrit or leucocyte counts are indicators of immune status and health, which can be affected, in a complex way, by exogenous as well as endogenous factors. Additionally, social context is known to be among the most potent stressors in group living individuals, therefore potentially influencing haematological parameters. However, with few exceptions, this potential causal relationship received only moderate scientific attention. Methods In a free-living and individually marked population of the highly social and long-lived Greylag goose, Anser anser, we relate variation in haematocrit (HCT, heterophils to lymphocytes ratio (H/L and blood leucocyte counts to the following factors: intrinsic (sex, age, raising condition, i.e. goose- or hand-raised, social (pair-bond status, pair-bond duration and parental experience and environmental (biologically relevant periods, ambient temperature factors. Blood samples were collected repeatedly from a total of 105 focal birds during three biologically relevant seasons (winter flock, mating season, summer. Results We found significant relationships between haematological parameters and social as well as environmental factors. During the mating season, unpaired individuals had higher HCT compared to paired and family individuals and this pattern reversed in fall. Similarly, H/L ratio was positively related to pair-bond status in a seasonally dependent way, with highest values during mating and successful pairs had higher H/L ratio than unsuccessful ones. Also, absolute number of leucocytes tended to vary depending on raising condition in a seasonally dependent way. Discussion Haematology bears a great potential in ecological and behavioural studies on wild vertebrates. In sum, we found that HTC, H/L ratio and absolute number of leucocytes are modulated by social factors and conclude that they may be considered valid indicators of individual stress load.

  5. Review of the social and environmental factors affecting the behavior and welfare of turkeys (Meleagris gallopavo).

    Science.gov (United States)

    Marchewka, J; Watanabe, T T N; Ferrante, V; Estevez, I

    2013-06-01

    In modern rearing systems, turkey producers often face economic losses due to increased aggression, feather pecking, cannibalism, leg disorders, or injuries among birds, which are also significant welfare issues. The main underlying causes appear to relate to rapid growth, flock size, density, poor environmental complexity, or lighting, which may be deficient in providing the birds with an adequate physical or social environment. To date, there is little information regarding the effect of these factors on turkey welfare. This knowledge is, however, essential to ensure the welfare of turkeys and to improve their quality of life, but may also be beneficial to industry, allowing better bird performance, improved carcass quality, and reduced mortality and condemnations. This paper reviews the available scientific literature related to the behavior of turkeys as influenced by the physical and social environment that may be relevant to advances toward turkey production systems that take welfare into consideration. We addressed the effects that factors such as density, group size, space availability, maturation, lightning, feeding, and transport may have over parameters that may be relevant to ensure welfare of turkeys. Available scientific studies were based in experimental environments and identified individual factors corresponding to particular welfare problems. Most of the studies aimed at finding optimal levels of rearing conditions that allow avoiding or decreasing most severe welfare issues. This paper discusses the importance of these factors for development of production environments that would be better suited from a welfare and economic point of view.

  6. Parkinson disease and Alzheimer disease: environmental risk factors.

    Science.gov (United States)

    Campdelacreu, J

    2014-01-01

    The purpose of this review is to update and summarise available evidence on environmental risk factors that have been associated with risk of Parkinson disease (PD) or Alzheimer disease (AD) and discuss their potential mechanisms. Evidence consistently suggests that a higher risk of PD is associated with pesticides and that a higher risk of AD is associated with pesticides, hypertension and high cholesterol levels in middle age, hyperhomocysteinaemia, smoking, traumatic brain injury and depression. There is weak evidence suggesting that higher risk of PD is associated with high milk consumption in men, high iron intake, chronic anaemia and traumatic brain injury. Weak evidence also suggests that a higher risk of AD is associated with high aluminium intake through drinking water, excessive exposure to electromagnetic fields from electrical grids, DM and hyperinsulinaemia, obesity in middle age, excessive alcohol consumption and chronic anaemia. Evidence consistently suggests that a lower risk of PD is associated with hyperuricaemia, tobacco and coffee use, while a lower risk of AD is associated with moderate alcohol consumption, physical exercise, perimenopausal hormone replacement therapy and good cognitive reserve. Weak evidence suggests that lower risk of PD is associated with increased vitamin E intake, alcohol, tea, NSAIDs, and vigorous physical exercise, and that lower risk of AD is associated with the Mediterranean diet, coffee and habitual NSAID consumption. Several environmental factors contribute significantly to risk of PD and AD. Some may already be active in the early stages of life, and some may interact with other genetic factors. Population-based strategies to modify such factors could potentially result in fewer cases of PD or AD. Copyright © 2012 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

  7. Recent progress in the genetics and epigenetics of paraoxonase: why it is relevant to children’s environmental health

    Science.gov (United States)

    Holland, N; Lizarraga, D; Huen, K

    2015-01-01

    Purpose of review Children are more susceptible to exposures in utero and during early childhood that may result in developmental problems and chronic diseases. Novel discoveries in the field of molecular epidemiology which can help explain susceptibility to exposures and disease will be demonstrated using the multifunctional enzyme paraoxonase (PON1) as an example. Recent findings The broad PON1 variability in humans, partly due to differences in genetics and age, can confer differential susceptibility because this enzyme can detoxify organophosphate pesticides and has antioxidant properties. Epigenetics plays a significant role in the mediation of the effects of environmental exposure on human health and is hypothesized to be a major contributing factor to the early-life origins of adult disease. Studies highlighted in this review demonstrate the relationship of PON1 polymorphisms with microRNA binding in addition to a link between DNA methylation in the transcriptional regulatory region with changes in PON1 enzyme levels. Other important methodologies such as ancestry informative markers and lactonase activity can enhance studies involving PON1. Summary This PON1 model demonstrates that integrating genetic and epigenetic factors as well as other novel methodologies can improve our understanding of important susceptibility factors linked to pediatric disease. PMID:25635583

  8. [Relevance of personal contextual factors of the ICF for use in practical social medicine and rehabilitation].

    Science.gov (United States)

    Grotkamp, S; Cibis, W; Bahemann, A; Baldus, A; Behrens, J; Nyffeler, I D; Echterhoff, W; Fialka-Moser, V; Fries, W; Fuchs, H; Gmünder, H P; Gutenbrunner, C; Keller, K; Nüchtern, E; Pöthig, D; Queri, S; Rentsch, H P; Rink, M; Schian, H-M; Schian, M; Schmitt, K; Schwarze, M; Ulrich, P; von Mittelstaedt, G; Seger, W

    2014-03-01

    Personal contextual factors play an essential part in the model of the International Classification of Functioning, Disability and Health (ICF). The WHO has not yet classified personal factors for global use although they impact on the functioning of persons positively or negatively. In 2010, the ICF working group of the German Society of Social Medicine and Prevention (DGSMP) presented a proposal for the classification of personal factors into 72 categories previously arranged in 6 chapters. Now a positioning paper has been added in order to stimulate a discussion about the fourth component of the ICF, to contribute towards a broader and common understanding about the nature of personal factors and to incite a dialogue among all those involved in health care as well as those people with or with-out health problems in order to gain a comprehensive perspective about a person's condition. © Georg Thieme Verlag KG Stuttgart · New York.

  9. Factors relevant to control of out-of-core radiation fields in BWRs

    International Nuclear Information System (INIS)

    Comley, G.C.W.

    1983-08-01

    Based on operating experience of BWRs around the world this report reviews major factors which appear to govern the problem of growth and intensity of radiation fields on out-of-core surfaces. While no one factor is dominant there is considerable evidence which links system chemistry, crud input and cobalt-rich sources to this problem. The report provides advice to BWR operators and system designers aimed at minimising doserates due to activity retention on coolant circuitry. (author)

  10. Environmental non-occupational risk factors associated with bladder cancer.

    Science.gov (United States)

    Ferrís, J; Berbel, O; Alonso-López, J; Garcia, J; Ortega, J A

    2013-10-01

    Bladder carcinoma (BC), due its high morbidity and relapsing course, generates significant economic and health care costs. Accordingly, review the environmental nonoccupational risk factors (RF), more or less evidence-based, in the etiology and pathogenesis of BC, because the involvement of urologists is essential for prevention. Review of the peer-reviewed literature (1987-2012) on nonoccupational environmental RF associated with BC retrieved from Medline, Embase and Science Citation Index. The search profiles have been "Risk factors/Epidemiology/Tobacco-smoking/Diet-nutrition-water-liquids/Radiation/Infectious/Farmacological drugs" and "Bladder cancer". Smoking was associated with 50% of BC in both sexes. Smokers have a 2-5 times higher risk than nonsmokers, directly proportional to the amount and duration of addiction. Drinking water contaminated with arsenic and chromium chlorination byproducts increases the risk of BC. High consumption of red meat and saturated fat may increase the risk, while high intake of fruits and vegetables decreases it. Patients treated with cyclophosphamide, ifosfamide and ionizing radiation have an increased risk of BC. Frequent and prolonged use of hair dyes and Schistosoma haematobium infestation increases the risk of BC. The reduction or the cessation of smoking decrease BC. The contaminant-free water consumption with the increase of vegetal foods favour BC prevention. Cancer survivors treated with cyclophosphamide, ifosfamide and radiation therapy should be monitored for early diagnosis of BC. Copyright © 2013 AEU. Published by Elsevier Espana. All rights reserved.

  11. Environmental factors contributed to circannual rhythm of semen quality.

    Science.gov (United States)

    Mao, Huan; Feng, Lei; Yang, Wan-Xi

    2017-01-01

    We investigated whether human semen parameters present circannual rhythm or not, and whether environmental factors exert on semen quality. This retrospective study used data of patients mainly from Reproductive Medicine Center and Urology and Andrology Clinic of a general hospital in China. Sperm concentration and motility were measured by computer aided sperm analysis (CASA). Sperm morphology was scored based on the strict criteria (WHO, 2010). The Kruskal-Wallis rank test was used to investigate the relationship between semen parameters and season/month. Partial correlation coefficients were used to analyze the relationship between semen parameters and environmental factors. In this study, we found that sperm concentration and total amount per ejaculate were significantly lower in summer and higher in winter. But, sperm progressive motility and motility were significantly higher in spring and summer (from March to June), lower in autumn and winter (September and October). Unexpectedly, normal sperm morphology and mixed agglutination reaction (MAR) positive rate didn't vary along with season or month. Furthermore, temperature was negatively related to sperm concentration and total amount per ejaculate. Precipitation was positively associated with progressive motility and normal sperm morphology, but negatively related to sperm head defect percentage. The length of sunlight was positively related to progressive motility. The Air Quality Index (AQI) was positively associated with semen volume and sperm total amount per ejaculate. These suggest seasonal and monthly variation underlying some semen parameters.

  12. Contribution of environmental factors to the risk of male infertility.

    Science.gov (United States)

    Oliva, A; Spira, A; Multigner, L

    2001-08-01

    An increasing number of reports suggest that chemical and physical agents in the environment, introduced and spread by human activity, may affect male fertility in humans. We investigated the relationships between exposure to environmental agents and seminal characteristics, and the concentrations of reproductive hormones in the serum of men seeking infertility treatment. We studied 225 male partners from consecutively recruited couples, who had their first infertility consultation between 1995 and 1998, in the Litoral Sur region of Argentina, one of the most productive farming regions in the world. A multivariate logistic regression model showed that exposure to pesticides and solvents is significantly associated with sperm threshold values well below the limit for male fertility. We also found that men exposed to pesticides had higher serum oestradiol concentrations, and that men exposed to solvents had lower LH concentrations than non-exposed men. All of these effects were greater in men with primary infertility than in men with secondary infertility. We have shown that environmental factors contribute to the severity of infertility, and that this may worsen the effects of pre-existing genetic or medical risk factors.

  13. Estimating Cyanobacteria Community Dynamics and its Relationship with Environmental Factors

    Science.gov (United States)

    Luo, Wenhuai; Chen, Huirong; Lei, Anping; Lu, Jun; Hu, Zhangli

    2014-01-01

    The cyanobacteria community dynamics in two eutrophic freshwater bodies (Tiegang Reservoir and Shiyan Reservoir) was studied with both a traditional microscopic counting method and a PCR-DGGE genotyping method. Results showed that cyanobacterium Phormidium tenue was the predominant species; twenty-six cyanobacteria species were identified in water samples collected from the two reservoirs, among which fourteen were identified with the morphological method and sixteen with the PCR-DGGE method. The cyanobacteria community composition analysis showed a seasonal fluctuation from July to December. The cyanobacteria population peaked in August in both reservoirs, with cell abundances of 3.78 × 108 cells L-1 and 1.92 × 108 cells L-1 in the Tiegang and Shiyan reservoirs, respectively. Canonical Correspondence Analysis (CCA) was applied to further investigate the correlation between cyanobacteria community dynamics and environmental factors. The result indicated that the cyanobacteria community dynamics was mostly correlated with pH, temperature and total nitrogen. This study demonstrated that data obtained from PCR-DGGE combined with a traditional morphological method could reflect cyanobacteria community dynamics and its correlation with environmental factors in eutrophic freshwater bodies. PMID:24448632

  14. Environmental factors associated with physician's engagement in communication activities.

    Science.gov (United States)

    Mazurenko, Olena; Hearld, Larry R

    2015-01-01

    Communication between patients and providers is a crucial component of effective care coordination and is associated with a number of desired patient and provider outcomes. Despite these benefits, physician-patient and physician-physician communication occurs infrequently. The purpose of this study was to examine the relationship between a medical practice's external environment and physician engagement in communication activities. This was a cross-sectional examination of 4,299 U.S. physicians' self-reported engagement in communication activities. Communication was operationalized as physician's time spent on communication with patients and other providers during a typical work day. The explanatory variables were measures of environmental complexity, dynamism, and munificence. Data sources were the Health Tracking Physician Survey, the Area Resource File database, and the Dartmouth Atlas. Binary logistic regression was used to estimate the association between the environmental factors and physician engagement in communication activities. Several environmental factors, including per capita income (odds ratio range, 1.17-1.38), urban location (odds ratio range, 1.08-1.45), fluctuations in Health Maintenance Organization penetration (odds ratio range, 3.47-13.22), poverty (odds ratio range, 0.80-0.97) and population rates (odds ratio range, 1.01-1.02), and the presence of a malpractice crisis (odds ratio range, 0.22-0.43), were significantly associated with communication. Certain aspects of a physician's external environment are associated with different modes of communication with different recipients (patients and providers). This knowledge can be used by health care managers and policy makers who strive to improve communication between different stakeholders within the health care system (e.g., patient and providers).

  15. Relevant factors for the impact of social media marketing strategies: Empirical study of the internet travel agency sector

    OpenAIRE

    Lebherz, Philipp Robert

    2011-01-01

    Projecte final de carrera fet en col.laboració amb Karlsruher Institut für Technologie English: Final proyect with the topic "relevant factors for the impact of social media marketing strategies - an empirical study of the internet travel agency sector" at Faculty of Informatics and the chair of management. Supervised by Ferran Sabaté and Antonio Cañabate. Student Philipp Lebherz.

  16. Genetic and environmental factors influencing the Placental Growth Factor (PGF) variation in two populations

    DEFF Research Database (Denmark)

    Sorice, Rossella; Ruggiero, Daniela; Nutile, Teresa

    2012-01-01

    . However, to date, no information is available regarding the genetics of PGF variability. Furthermore, even though the effect of environmental factors (e.g.: cigarette smoking) on angiogenesis has been explored, no data on the influence of these factors on PGF levels have been reported so far. Here we have......Placental Growth Factor (PGF) is a key molecule in angiogenesis. Several studies have revealed an important role of PGF primarily in pathological conditions (e.g.: ischaemia, tumour formation, cardiovascular diseases and inflammatory processes) suggesting its use as a potential therapeutic agent...

  17. Relevant Factors in the Process of Socialization, Involvement and Belonging of Descendants in Family Businesses

    Directory of Open Access Journals (Sweden)

    Melquicedec Lozano-Posso

    2016-12-01

    Full Text Available This research works toward the identification of the factors that comprise the process of socialization, involvement and initial belonging of descendants in family businesses and the key relationships between them. By means of a qualitative detailed study of four cases, complemented by a quantitative survey of 274 Colombian family businesses, the authors generate a new model that takes into account both factors explored in previous research as well as others identified in this study. Findings confirm the specific dependency of each stage on the subsequent ones; socialization influences involvement, which in turn influences the belonging of the descendants to the family business, with a strong presence of factors such as knowledge, leadership, mode, timing, and motivation. Those responsible for the orientation of potential successors may examine these findings in order to optimize their preparation efforts and support of family human resources for the continuity of the business.

  18. [Adoption of new technologies by health services: the challenge of analyzing relevant factors].

    Science.gov (United States)

    Trindade, Evelinda

    2008-05-01

    The exponential increase in the incorporation of health technologies has been considered a key factor in increased expenditures by the health sector. Such decisions involve multiple levels and stakeholders. Decentralization has multiplied the decision-making levels, with numerous difficult choices and limited resources. The interrelationship between stakeholders is complex, in creative systems with multiple determinants and confounders. The current review discusses the interaction between the factors influencing the decisions to incorporate technologies by health services, and proposes a structure for their analysis. The application and intensity of these factors in decision-making and the incorporation of products and programs by health services shapes the installed capacity of local and regional networks and modifies the health system. Empirical observation of decision-making and technology incorporation in Brazilian health services poses an important challenge. The structured recognition and measurement of these variables can assist proactive planning of health services.

  19. Bladder cancer, a review of the environmental risk factors

    Directory of Open Access Journals (Sweden)

    Letašiová Silvia

    2012-06-01

    Full Text Available Abstract Background Many epidemiological studies and reviews have been performed to identify the causes of bladder cancer. The aim of this review is to investigate the links between various environmental risk factors and cancer of the bladder. Methods A systematic literature search was performed using PubMed, Science Direct, Scopus, Scholar Google and Russian Google databases to identify reviews and epidemiological studies on bladder cancer risk factors associated with the environment published between 1998 and 2010. Only literature discussing human studies was considered. Results Smoking, mainly cigarette smoking, is a well known risk factor for various diseases, including bladder cancer. Another factor strongly associated with bladder cancer is exposure to arsenic in drinking water at concentrations higher than 300 µg/l. The most notable risk factor for development of bladder cancer is occupational exposure to aromatic amines (2-naphthylamine, 4-aminobiphenyl and benzidine and 4,4'-methylenebis(2-chloroaniline, which can be found in the products of the chemical, dye and rubber industries as well as in hair dyes, paints, fungicides, cigarette smoke, plastics, metals and motor vehicle exhaust. There are also data suggesting an effect from of other types of smoking besides cigarettes (cigar, pipe, Egyptian waterpipe, smokeless tobacco and environmental tobacco smoking, and other sources of arsenic exposure such as air, food, occupational hazards, and tobacco. Other studies show that hairdressers and barbers with occupational exposure to hair dyes experience enhanced risk of bladder cancer. For example, a study related to personal use of hair dyes demonstrates an elevated bladder cancer risk for people who used permanent hair dyes at least once a month, for one year or longer. Conclusion Smoking, in particular from cigarettes, exposure to arsenic in drinking water, and occupational exposure to aromatic amines and 4,4'-methylenebis(2-chloroaniline

  20. Increasing the Adaptive Capacity of the Organism When Exposed to Adverse Environmental Factors Through Phytoadaptogens

    Science.gov (United States)

    Babii, N. V.; Pomozova, V. A.; Kiseleva, T. F.; Romanenko, V. O.

    2017-07-01

    The Problem of improving the quality of life of the population in modern conditions is the most relevant. The level of human health largely depends on the quality of the environment. Of special importance are the risk factors for the spread of diseases like environmental pollution, social conditions and bad habits. To the emergence of ecologically dependent diseases leads the combined impact of technogenic, social-economic, natural-climatic factors. The introduction of the principles of biotechnology, nanotechnology and innovations in industrial processing of plant resources, especially natural adaptogens, contributes to the production of balanced, ecologically clean food products functional purpose, the use of which will significantly minimize the adverse effects of the environment on humans.

  1. Environmental risk factors for sudden infant death syndrome in Japan.

    Science.gov (United States)

    Hirabayashi, Masako; Yoshinaga, Masao; Nomura, Yuichi; Ushinohama, Hiroya; Sato, Seiichi; Tauchi, Nobuo; Horigome, Hitoshi; Takahashi, Hideto; Sumitomo, Naokata; Shiraishi, Hirohiko; Nagashima, Masami

    2016-12-01

    While the prevalence of sudden infant death syndrome (SIDS) has decreased worldwide, this decline has plateaued recently. Strategies are needed to resume the constant decrease of SIDS in Japan. A prospective electrocardiographic screening program for infants was performed between July 2010 and March 2011. Parents of 4319 infants were asked about environmental factors related to SIDS through questionnaires at a one-month medical checkup and one year. Parental awareness of prone position, smoke exposure, and breast feeding as environmental factors were 81.4 %, 69.0 %, and 47.8 %, respectively. The prevalence of laying infants exclusively in a supine position was 96.7 %. At the one-month medical checkup, smoking prevalence was 41.7 % in fathers and 2.1 % in mothers. Maternal smoking prevalence was significantly increased at one year after (p Japan. Smoking cessation programs should be further implemented for parents to decrease risks of SIDS in Japan. What is Known: • The prevalence of sudden infant death syndrome (SIDS) has decreased worldwide, however, this decline has plateaued recently. What is New: • Most infants were laid sleeping in the supine position (96.7 %) and were fed breast milk or a mix of expressed milk and formula (92.7 %), and 2.1 % of mothers smoked at the one-month medical checkup. • Maternal smoking prevalence significantly increased from the one-month medical checkup to one year later, and smoking mothers were more likely to feed infants by formula rather than breast milk. • Independent risk factors for new or continued maternal smoking habits included younger maternal age, maternal smoking habits at one month, and paternal smoking habits one year later.

  2. Transfer of Patients in a Telestroke Network: What Are the Relevant Factors for Making This Decision?

    Science.gov (United States)

    Klingner, Carsten M; Brodoehl, Stefan; Funck, Laura; Klingner, Caroline C; Berrouschot, Jörg; Witte, Otto W; Günther, Albrecht

    2018-02-01

    Background/Introduction: Current telestroke network consultations are focused on decision-making in the hyperacute stage of stroke management. The two main questions in telestroke consultations are whether thrombolysis should be initiated and whether the patient should be transferred to a hub hospital. Although guidelines exist for initiating intravenous thrombolytic therapy, the question of whether patients should be transferred is far more elusive. In this study, we investigated the factors involved in the decision to transfer stroke patients to a hub hospital. We were particularly interested in identifying factors that promote or impede the transfer of patients. We enrolled 1,615 cases of telestroke consultation of the University Hospital Jena. The two main factors that independently influenced the probability of transferring a patient were the patient's age and the identification of a proximal vessel occlusion. Interestingly, factors such as the severity of symptoms and the time elapsed from symptom onset were not found to have an independent influence on the decision to transfer a patient. The transfer of most patients was justified by the possibility of performing interventional reperfusion therapy. We discuss the effectiveness of the current decision-making process and possible ways to improve decision-making for a more effective selection of patients who would benefit from transfer. The decision-making process to a transfer patient is not standardized and constitutes a trade-off between the intention to treat all possible patients while avoiding the transfer of patients without treatment options.

  3. Corporate Image of Public Higher Education Institutions: Relevant Factors to Distance Learning Students

    Science.gov (United States)

    da Costa, Fabio R.; Pelissari, Anderson S.; Gonzalez, Inayara V. D. P.

    2018-01-01

    Technological advances are generating a significant increase in the supply of distance learning (DL) courses via the Internet, increasing the importance of this type of education for the university's structure. This article identifies factors associated with perceptions of the public higher education institutions' image from the perspective of DL…

  4. Physical interactions among plant MADS-box transcription factors and their biological relevance

    NARCIS (Netherlands)

    Nougalli Tonaco, I.A.

    2008-01-01

    The biological interpretation of the genome starts from transcription, and many different signaling pathways are integrated at this level. Transcription factors play a central role in the transcription process, because they select the down-stream genes and determine their spatial and temporal

  5. The prognostic relevance of psychological factors with regard to participation and success in table-tennis.

    Science.gov (United States)

    Martinent, Guillaume; Cece, Valérian; Elferink-Gemser, Marije Titia; Faber, Irene Renate; Decret, Jean-Claude

    2018-05-15

    This study examined the prognostic relevance of self-determined motivation, coping, burnout, perceived stress and recovery experienced by 159 youth table-tennis players involved in intensive training centers with regard to their participation and success six years later. Results of ANCOVAs showed that players who still practiced at time 2 (T2; six years later; n = 130) reported lower time 1 (T1; while they were involved in intensive training centers) amotivation (large effect), disengagement-oriented coping, sport devaluation and reduced accomplishment (moderate effects) than their counterparts who dropped out at T2 (n = 29). Results of ANCOVAs also showed that international (n = 18) and/or national players (n = 86) at T2 reported significantly lower T1 amotivation (large effect), disengagement-oriented coping and sport devaluation (moderate effects) in comparison to regional (n = 26) players at T2. Finally results of correlational analyses showed that T2 performance and/or six-year performance progress were significantly and weakly correlated with introjected and external regulations, perceived stress and perceived recovery, and significantly and moderately correlated with amotivation, disengagement-oriented coping, sport devaluation, and reduced accomplishment. Overall, this study provided insights into the role played by self-determined motivation, coping, burnout, perceived stress and recovery in the table-tennis players' dropout and performance level six years later.

  6. Sorption of environmentally relevant radionuclides (U(VI), Np(V)) and lanthanides (Nd(III)) on feldspar and mica

    Energy Technology Data Exchange (ETDEWEB)

    Richter, Constanze

    2015-11-05

    A safe storage of radioactive waste in repositories is an important task to protect humans and the environment from radio- and chemotoxicity. Long-term safety assessments predict the behavior of potential environmental contaminants like the actinides plutonium, uranium, or neptunium, in the near and far field of repositories. For such safety assessments, it is necessary to know the migration behavior of the contaminants in the environment, which is mainly dependent on the aquatic speciation, the solubility product of relevant solid phases, and the retardation due to sorption on surrounding minerals. Thus, an investigation of sorption processes of contaminants onto different minerals as well as the derivation of mineral specific surface complexation model (SCM) parameters is of great importance. Feldspar and mica are widely distributed in nature. They occur as components of granite, which is considered as a potential host rock for a repository in Germany, and in numerous other rocks, and thus also in the far field of nearly all repositories. However, their sorption behavior with actinides has only been scarcely investigated until now. In order to better characterize these systems and subsequently to integrate these minerals into the long-term safety assessments, this work focuses on the investigation of the sorption behavior of U(VI), Np(V), and Nd(III) as analogue for An(III) onto the minerals orthoclase and muscovite, representing feldspars and mica, respectively. All investigations were performed under conditions relevant to the far field of a repository. In addition to the extensive characterization of the minerals, batch sorption experiments, spectroscopic investigations, and surface complexation modeling were performed to elucidate the uptake and speciation of actinides on the mineral surfaces. In addition, the influence of microorganisms naturally occurring on the mineral surfaces and the effect of Ca{sup 2+} on U(VI) uptake on the minerals was studied. The

  7. Sorption of environmentally relevant radionuclides (U(VI), Np(V)) and lanthanides (Nd(III)) on feldspar and mica

    International Nuclear Information System (INIS)

    Richter, Constanze

    2015-01-01

    A safe storage of radioactive waste in repositories is an important task to protect humans and the environment from radio- and chemotoxicity. Long-term safety assessments predict the behavior of potential environmental contaminants like the actinides plutonium, uranium, or neptunium, in the near and far field of repositories. For such safety assessments, it is necessary to know the migration behavior of the contaminants in the environment, which is mainly dependent on the aquatic speciation, the solubility product of relevant solid phases, and the retardation due to sorption on surrounding minerals. Thus, an investigation of sorption processes of contaminants onto different minerals as well as the derivation of mineral specific surface complexation model (SCM) parameters is of great importance. Feldspar and mica are widely distributed in nature. They occur as components of granite, which is considered as a potential host rock for a repository in Germany, and in numerous other rocks, and thus also in the far field of nearly all repositories. However, their sorption behavior with actinides has only been scarcely investigated until now. In order to better characterize these systems and subsequently to integrate these minerals into the long-term safety assessments, this work focuses on the investigation of the sorption behavior of U(VI), Np(V), and Nd(III) as analogue for An(III) onto the minerals orthoclase and muscovite, representing feldspars and mica, respectively. All investigations were performed under conditions relevant to the far field of a repository. In addition to the extensive characterization of the minerals, batch sorption experiments, spectroscopic investigations, and surface complexation modeling were performed to elucidate the uptake and speciation of actinides on the mineral surfaces. In addition, the influence of microorganisms naturally occurring on the mineral surfaces and the effect of Ca 2+ on U(VI) uptake on the minerals was studied. The

  8. Anti-smoking policy in Russia: Relevant factors and program planning.

    Science.gov (United States)

    Kossova, Tatiana; Kossova, Elena; Sheluntcova, Maria

    2018-08-01

    In this paper, we consider anti-smoking policy in Russia and the socioeconomic factors that influence an individual's decision to smoke. Among various factors, we investigate the individual time preferences of Russians. To estimate individual time preferences, we use an experiment in which survey respondents are given hypothetical money prizes. We find that being middle-aged, being unmarried and having parents who smoke are positively correlated with both men and women's likelihood of taking up smoking in Russia. We consider the possible endogeneity of an individual's health status and find a positive relationship between smoking and the time preferences of Russians. Our findings confirm that decisionmakers should devote their efforts primarily to developing restrictive anti-smoking policy. The choice of policy measures should be guided by the individual characteristics of target population groups. Social advertising, public lectures and preventive care should be actively engaged in forming public attitudes towards smoking. Copyright © 2018 Elsevier Ltd. All rights reserved.

  9. [Hereditary heterozygous factor VII deficiency in patients undergoing surgery : Clinical relevance].

    Science.gov (United States)

    Woehrle, D; Martinez, M; Bolliger, D

    2016-10-01

    A hereditary deficiency in coagulation factor VII (FVII) may affect the international normalized ratio (INR) value. However, FVII deficiency is occasionally associated with a tendency to bleed spontaneously. We hypothesized that perioperative substitution with coagulation factor concentrates might not be indicated in most patients. In this retrospective data analysis, we included all patients with hereditary heterozygous FVII deficiency who underwent surgical procedures at the University Hospital Basel between December 2010 and November 2015. In addition, by searching the literature, we identified publications reporting patients with FVII deficiency undergoing surgical procedures without perioperative substitution. We identified 22 patients undergoing 46 surgical procedures, resulting in a prevalence of 1:1500-2000. Coagulation factor concentrates were administered during the perioperative period in 15 procedures (33 %), whereas in the other 31 procedures (66 %), FVII deficiency was not substituted. No postoperative bleeding or thromboembolic events were reported. In addition, we found no differences in pre- and postoperative hemoglobin and coagulation parameters, with the exception of an improved postoperative INR value in the substituted group. In the literature review, we identified five publications, including 125 patients with FVII deficiency, undergoing 213 surgical procedures with no perioperative substitution. Preoperative substitution using coagulation factor concentrates does not seem to be mandatory in patients with an FVII level ≥15 %. For decision-making on preoperative substitution, patient history of an increased tendency to bleed may be more important than the FVII level or increased INR value.

  10. Expatriate vs locals: career management processes and relevant factors in multinationals

    OpenAIRE

    Veríssimo, Tiago Manuel Gaspar

    2011-01-01

    Mestrado em Gestão The aim of this investigation is to determine in what extent the individual and organizational factors are liable for the motivation intensity and for the expected success of an international assignment. Therefore, we also cleared the variables that can influence these behaviours and create a higher perception of success in which concerns employees on an international assignment. Survey data were collected from 130 non-expatriates and from 32 expatriates (from which o...

  11. A teacher-centered exploration of the relevance of social factors to theory of mind development.

    Science.gov (United States)

    Wright, Barlow C; Mahfoud, Janina

    2014-02-01

    Many accounts of children's Theory of Mind (ToM) development favor a cognitive explanation, for example, in terms of mental representational improvements at or before 4 years. Here, we investigated whether social factors as rated by a child's teacher, are related to ToM development. We tested 82 children of 3-6 years on each of four ToM tasks, and their class teacher completed a social questionnaire about each child's playing behavior, sharing, talkativeness, confidence, aggressiveness and outgoingness. A measure of task memory and the child's gender were also recorded. Here, children generally passed ToM tasks after 5 years-old, but no one gender performed reliably better than the other. Teacher-rated confidence and playing behavior were correlated to ToM. But in a regression analysis, these were replaced by teacher-rated talkativeness; with age and memory given primacy in both sets of analyses. It is concluded that maturation and cognitive factors may well have primacy but social factors, facilitated during early primary education, must also be given a role in ToM development. © 2013 Scandinavian Psychological Associations and John Wiley & Sons Ltd.

  12. Polypharmacy as a Risk Factor for Clinically Relevant Sarcopenia: Results From the Berlin Aging Study II.

    Science.gov (United States)

    König, Maximilian; Spira, Dominik; Demuth, Ilja; Steinhagen-Thiessen, Elisabeth; Norman, Kristina

    2017-12-12

    Sarcopenia affects more than 10% of older adults. Next to age-associated physiologic changes, diseases like diabetes or inflammatory, neurological, malignant and endocrine disorders may contribute to the development of sarcopenia. Likewise, polypharmacy, i.e., multiple drug use, is common among older adults. Although the two conditions frequently co-occur, the association of polypharmacy with sarcopenia has not yet been examined. We investigated the association of polypharmacy and sarcopenia in a large cohort of community-dwelling older adults (60-84 years). Thousand five hundred and two participants from the Berlin Aging Study II were included. Polypharmacy was defined as concurrent use of 5 or more drugs (prescription and nonprescription). Body composition was assessed with dual-energy X-ray absorptiometry, and appendicular lean mass (ALM) was calculated as sum of the four limbs' lean mass. Sarcopenia was defined as low ALM-to-body mass index (BMI)-ratio using validated sex-specific cutoffs. Mean age was 68.7 ± 3.7 years, 50.7% were female. The median (interquartile range) number of drugs was 2 (1-4); 21.1% of subjects reported regular use of ≥5 drugs. Subjects with polypharmacy were more often sarcopenic according to the applied ALM/BMI-cutoffs (16.3% vs 6.9%, p sarcopenia (odds ratio = 2.24, 95% confidence interval [CI] = 1.33-3.75). Polypharmacy is associated with clinically relevant sarcopenia, as assessed by a low ALM/BMI. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  13. ENVIRONMENTAL PROTECTION SUSTAINABILITY STRATEGIC FACTOR IN THE ENERGY INDUSTRY

    Directory of Open Access Journals (Sweden)

    CÎRNU Doru

    2015-06-01

    Full Text Available We propose to conceive an environmental strategy intended to integrate harmoniously Gorj energy industry with principles of sustainable development. The sustainable development complies trinomial: ecological-economic-social. In our view, sustainable development, requires clean water and unpolluted air, land consolidated rejuvenated forests, biodiversity and protected nature reserves, churches and monasteries secular admired by visitors, welcoming places entered in the natural and cultural harmony. It is also necessary to reduce the pressure generated by socio-economic factors on the environment and the principles of sustainable development. The quality of life in urban and rural areas show extreme differences compared to European standards. For efficiency, we addressed the modeling method by designing a model valid for all thermoelectric power plants based on fossil fuels, allowing simultaneously, so adding value and environmental protection. The general objective that we propose for the environment, natural resources and patrimony, is related to the prevention of climate change by limiting the emission of toxic gases and their adverse effects on the environment The achievement of strategic objectives and implementation of proposals submitted, we consider that would have a double impact, on the one side, to protect the environment and the quality of life and, on the other side a positive influence on economic and social level.

  14. Apoptosis in fish: environmental factors and programmed cell death.

    Science.gov (United States)

    AnvariFar, Hossein; Amirkolaie, Abdolsamad Keramat; Miandare, Hamed Kolangi; Ouraji, Hossein; Jalali, M Ali; Üçüncü, Sema İşisağ

    2017-06-01

    Apoptosis, a form of programmed cell death, is a critical component in maintaining homeostasis and growth in all tissues and plays a significant role in immunity and cytotoxicity. In contrast to necrosis or traumatic cell death, apoptosis is a well-controlled and vital process characterized mainly by cytoplasmic shrinkage, chromatin condensation, DNA fragmentation, membrane blebbing and apoptotic bodies. Our understanding of apoptosis is partly based on observations in invertebrates but mainly in mammals. Despite the great advantages of fish models in studying vertebrate development and diseases and the tremendous interest observed in recent years, reports on apoptosis in fish are still limited. Although apoptotic machinery is well conserved between aquatic and terrestrial organisms throughout the history of evolution, some differences exist in key components of apoptotic pathways. Core parts of apoptotic machinery in fish are virtually expressed as equivalent to the mammalian models. Some differences are, however, evident, such as the extrinsic and intrinsic pathways of apoptosis including lack of a C-terminal region in the Fas-associated protein with a death domain in fish. Aquatic species inhabit a complex and highly fluctuating environment, making these species good examples to reveal features of apoptosis that may not be easily investigated in mammals. Therefore, in order to gain a wider view on programmed cell death in fish, interactions between the main environmental factors, chemicals and apoptosis are discussed in this review. It is indicated that apoptosis can be induced in fish by exposure to environmental stressors during different stages of the fish life cycle.

  15. SOME ENVIRONMENTEAL FACTORS AFFECTING BROILER HOUSING IN WINTER SEASON

    Directory of Open Access Journals (Sweden)

    Tarek FOUDA

    2013-01-01

    Full Text Available The main objective of this study was to study some environmental factors affecting broiler housing in winter season. The results showed that, temperature fluctuations between house ceiling and floor ranged between 0.4 to 5.93 ºC during the first two days of age. The average house temperature reduced gradually from 29.7 to 21.3 ºC. The indoor relative humidity ranged between 43.6 to 74.3 %. Specific heating power, specific fuel consumption and heating energy requirements ranged between 3850.2 W/ºC , 0.34 kg /h. ºC and 308.9 kJ/h. kg at the first week of age to 6213.4 W/ºC , 0.36 kg /h. ºC and 19.3 kJ/h. kg at the end of the life respectively

  16. The rise of food allergy: Environmental factors and emerging treatments

    Directory of Open Access Journals (Sweden)

    Sara Benedé

    2016-05-01

    Full Text Available Food allergy has rapidly increased in prevalence, suggesting an important role for environmental factors in disease susceptibility. The immune response of food allergy is characterized by IgE production, and new findings from mouse and human studies indicate an important role of the cytokine IL-9, which is derived from both T cells and mast cells, in disease manifestations. Emerging evidence suggests that route of exposure to food, particularly peanut, is important. Exposure through the skin promotes sensitization while early exposure through the gastrointestinal tract promotes tolerance. Evidence from mouse studies indicate a role of the microbiome in development of food allergy, which is supported by correlative human studies showing a dysbiosis in food allergy. There is no approved treatment for food allergy, but emerging therapies are focused on allergen immunotherapy to provide desensitization, while pre-clinical studies are focused on using adjuvants or novel delivery approaches to improve efficacy and safety of immunotherapy.

  17. Mapping Environmental Inequalities Relevant for Health for Informing Urban Planning Interventions-A Case Study in the City of Dortmund, Germany.

    Science.gov (United States)

    Flacke, Johannes; Schüle, Steffen Andreas; Köckler, Heike; Bolte, Gabriele

    2016-07-13

    Spatial differences in urban environmental conditions contribute to health inequalities within cities. The purpose of the paper is to map environmental inequalities relevant for health in the City of Dortmund, Germany, in order to identify needs for planning interventions. We develop suitable indicators for mapping socioeconomically-driven environmental inequalities at the neighborhood level based on published scientific evidence and inputs from local stakeholders. Relationships between socioeconomic and environmental indicators at the level of 170 neighborhoods were analyzed continuously with Spearman rank correlation coefficients and categorically applying chi-squared tests. Reclassified socioeconomic and environmental indicators were then mapped at the neighborhood level in order to determine multiple environmental burdens and hotspots of environmental inequalities related to health. Results show that the majority of environmental indicators correlate significantly, leading to multiple environmental burdens in specific neighborhoods. Some of these neighborhoods also have significantly larger proportions of inhabitants of a lower socioeconomic position indicating hotspots of environmental inequalities. Suitable planning interventions mainly comprise transport planning and green space management. In the conclusions, we discuss how the analysis can be used to improve state of the art planning instruments, such as clean air action planning or noise reduction planning towards the consideration of the vulnerability of the population.

  18. Safety factor profile dependence of turbulent structure formation in relevant to internal transport barrier relaxation

    International Nuclear Information System (INIS)

    Tokunaga, S.; Yagi, M.; Itoh, S.-I.; Itoh, K.

    2009-01-01

    Full text: It is widely understood that the improved confinement mode with transport barrier is necessary to achieve the self-ignition condition in ITER. The negative magnetic shear, mean ExB flow shear, and zonal flow are considered to play important roles for ITB formation. In our previous study, it is found that the non-linear interaction between the meso-scale modes produces non-local energy transfer to the off-resonant mode in the vicinity of q min surface and brings global relaxation of the temperature profile involving ITB collapse. Experimental studies indicate that a relationship exists between the ITB formation and safety factor q-profile, with a reversed magnetic shear (RS) configuration. Transitional ITB events occur on the low-order rational resonant surface. The ITB shape and location depend on the q-profile and q min position. These observations indicate that the q-profile might play an essential role in determining the turbulent structure. In this study, the effect of safety factor profile on the ion temperature gradient driven drift wave (ITG) turbulence is investigated using a global non-linear simulation code based on the gyro-fluid model. A heat source and toroidal momentum source are introduced. Dependence of safety factor profiles on ITB formation and its stability is examined to clarify the influence of the radial distribution of the rational surfaces and the q min value. It is found that the nonlinearly excited meso-scale mode in the vicinity of q min depends on the value of q min . A detailed analysis of the structure selection rule is in progress. (author)

  19. Relationship between genetic and environmental factors and hypercholesterolemia in children.

    Science.gov (United States)

    Robledo, Jorge A; Siccardi, Leonardo J

    2016-10-01

    Pediatric hypercholesterolemia has increased over the past decades. Knowing the environmental and genetic factors that have an impact on it would allow establishing more adequate screening guidelines. To determine if there is an association between genetic and environmental factors and hypercholesterolemia in children. To assess the predictive qualities of outcome measures associated with hypercholesterolemia. Observational, analytical, cross-sectional study. students from all schools located in Jovita. Age: > 6 and hypercholesterolemia. Three hundred and eighty-two students were included. Their mean cholesterol level was 168 mg/dL, and 13.4% had hypercholesterolemia. A sedentary lifestyle was observed in 22.8%, and obesity, in 10.5%. A positive FMH, a high/ middle SEL, and obesity were associated with hypercholesterolemia (OR: 2.10, 2.10 and 2.05, respectively). No association was found between physical activity and fat/cholesterol intake and hypercholesterolemia. A positive FMH and a high/middle SEL were sensitive enough (75% and 88%) to predict hypercholesterolemia. The presence of hypercholesterolemia inboth parents in relation to hypercholesterolemia in their child showed an OR of 9.59, a sensitivity of 73%, a specificity of 71%, a positive predictive value of 57%, and a negative predictive value of 83%. A positive FMH, a high/ middle SEL, and obesity were associated with hypercholesterolemia in children. The presence of hypercholesterolemia in both parents was associated with hypercholesterolemia in their child and showed itself to be a great potential predictor and screening criterion. Sociedad Argentina de Pediatría.

  20. Effects of an Environmentally-relevant Mixture of Pyrethroid Insecticides on Spontaneous Activity in Primary Cortical Networks on Microelectrode Arrays

    Data.gov (United States)

    U.S. Environmental Protection Agency — This manuscript tests the hypothesis of dose additivity of an environmental mixture of pyrethriod insecticides at the level of network function, in vitro. The...

  1. AN INTERACTION MODEL BETWEEN ENVIRONMENTAL FACTORS AND BLACK RICE GROWTH IN IRRIGATED ORGANIC PADDY FIELD

    Directory of Open Access Journals (Sweden)

    Budiman

    2015-02-01

    Full Text Available Black rice production in organic farming system does not meet the demand of local customers because of its low productivity. This research aimed to set an interaction model using multivariate analysis via smartPLS to identify environmental factors which simultaneously affects the growth of black rice. The growth of black rice in two irrigated organic paddy field in Malang, Indonesia was observed during planting period from November 2011 to March 2012. In each rice field, the growth was periodically recorded during planting periods: 19-29 days after planting (dap, 41-45 dap, 62-66 dap, 77-81 dap, 90-94 dap and 104-106 dap. Environmental factors such as water quantities, soil conditions, weed communities and cultivation system around the black rice population were also measured. Black rice growth was influenced simultaneously by water quantities, soil, weed communities and cultivating systems with predictive-relevance value reaching 92.83%. Based on the model, water quantities in paddy field is a key factor which directly and indirectly determined the growth and productivity of black rice.

  2. Recognition of the mycobacterial cord factor by Mincle: relevance for granuloma formation and resistance to tuberculosis

    Directory of Open Access Journals (Sweden)

    Roland eLang

    2013-01-01

    Full Text Available The world’s most successful intracellular bacterial pathogen, Mycobacterium tuberculosis (MTB, survives inside macrophages by blocking phagosome maturation and establishes chronic infection characterized by the formation of granulomas. Trehalose-6,6-dimycolate (TDM, the mycobacterial cord factor, is the most abundant cell wall lipid of virulent mycobacteria, is sufficient to cause granuloma formation, and has long been known to be a major virulence factor of MTB. Recently, TDM has been shown to activate the Syk-Card9 signaling pathway in macrophages through binding to the C-type lectin receptor Mincle. The Mincle-Card9 pathway is required for activation of macrophages by TDM in vitro and for granuloma formation in vivo following injection of TDM. Whether this pathway is also exploited by MTB to reprogram the macrophage into a comfortable niche has not been explored yet. Several recent studies have investigated the phenotype of Mincle-deficient mice in mycobacterial infection, yielding divergent results in terms of a role for Mincle in host resistance. Here, we review these studies, discuss possible reasons for discrepant results and highlight open questions in the role of Mincle and other C-type lectin receptors in the infection biology of MTB.

  3. Distinctive Risk Factors and Phenotype of Younger Patients With Resistant Hypertension: Age Is Relevant.

    Science.gov (United States)

    Ghazi, Lama; Oparil, Suzanne; Calhoun, David A; Lin, Chee Paul; Dudenbostel, Tanja

    2017-05-01

    Resistant hypertension, defined as blood pressure >140/90 mm Hg despite using ≥3 antihypertensive medications, is a well-recognized clinical entity. Patients with resistant hypertension are at an increased risk of cardiovascular disease compared with those with more easily controlled hypertension. Coronary heart disease mortality rates of younger adults are stagnating or on the rise. The purpose of our study was to characterize the phenotype and risk factors of younger patients with resistant hypertension, given the dearth of data on cardiovascular risk profile in this cohort. We conducted a cross-sectional analysis with predefined age groups of a large, ethnically diverse cohort of 2170 patients referred to the Hypertension Clinic at the University of Alabama at Birmingham. Patients (n=2068) met the inclusion criteria and were classified by age groups, that is, ≤40 years (12.7% of total cohort), 41 to 55 years (32.1%), 56 to 70 years (36.1%), and ≥71 years (19.1%). Patients aged ≤40 years compared with those aged ≥71 years had significantly earlier onset of hypertension (24.7±7.4 versus 55.0±14.1 years; P hypertension, younger individuals have a distinct phenotype characterized by overlapping risk factors and comorbidities, including obesity, high aldosterone, and high dietary sodium intake compared with elderly. © 2017 American Heart Association, Inc.

  4. Evolutionary changes of Hox genes and relevant regulatory factors provide novel insights into mammalian morphological modifications.

    Science.gov (United States)

    Li, Kui; Sun, Xiaohui; Chen, Meixiu; Sun, Yingying; Tian, Ran; Wang, Zhengfei; Xu, Shixia; Yang, Guang

    2018-01-01

    The diversity of body plans of mammals accelerates the innovation of lifestyles and the extensive adaptation to different habitats, including terrestrial, aerial and aquatic habitats. However, the genetic basis of those phenotypic modifications, which have occurred during mammalian evolution, remains poorly explored. In the present study, we synthetically surveyed the evolutionary pattern of Hox clusters that played a powerful role in the morphogenesis along the head-tail axis of animal embryos and the main regulatory factors (Mll, Bmi1 and E2f6) that control the expression of Hox genes. A deflected density of repetitive elements and lineage-specific radical mutations of Mll have been determined in marine mammals with morphological changes, suggesting that evolutionary changes may alter Hox gene expression in these lineages, leading to the morphological modification of these lineages. Although no positive selection was detected at certain ancestor nodes of lineages, the increased ω values of Hox genes implied the relaxation of functional constraints of these genes during the mammalian evolutionary process. More importantly, 49 positively-selected sites were identified in mammalian lineages with phenotypic modifications, indicating adaptive evolution acting on Hox genes and regulatory factors. In addition, 3 parallel amino acid substitutions in some Hox genes were examined in marine mammals, which might be responsible for their streamlined body. © 2017 The Authors. Integrative Zoology published by International Society of Zoological Sciences, Institute of Zoology/Chinese Academy of Sciences and John Wiley & Sons Australia, Ltd.

  5. Social and individual determinants of car use. Application of the model Determinants of environmentally-relevant consumer behavior; Maatschappelijke en individuele determinanten van autogebruik. Toepassing van het model Determinanten van milieurelevant consumentengedrag

    Energy Technology Data Exchange (ETDEWEB)

    Steg, L.; Arnold, M.; Ras, M.; Van Velzen, E.

    1997-11-01

    It is increasingly recognised that environmental problems are largely due to the behaviour of individual consumers and that one way of tackling those problems therefore consists of a change in behaviour. A good diagnosis based on a clear model is indispensable for an effective change in behaviour. For this reason the SCP has developed a conceptual model entitled Determinants of environmentally-relevant consumer behaviour (Dutch abbreviation is DMCG). This is a diagnostic model for the systematic analysis of relevant factors determining environmental behaviour. The diagnosis relates not just to the current situation but also to the historical developments that have led up to that situation as well as expectations concerning future developments in behaviour. A detailed diagnosis of this kind provides insight into the way in which environmentally behaviour can be influenced: policy instruments will be more effective and efficient the more they are geared to significant determinants of behaviour. The DMCG model has been used in this survey to explain the use of cars. The purpose of the study is to investigate the possibilities and limitations of the DMCG model. A second objective is to identify the factors that influence (or have influenced) the increasing use of cars. 88 refs.

  6. What environmental factors influence resumption of valued activities post stroke: a systematic review of qualitative and quantitative findings.

    Science.gov (United States)

    Jellema, Sandra; van Hees, Suzanne; Zajec, Jana; van der Sande, Rob; Nijhuis-van der Sanden, Maria Wg; Steultjens, Esther Mj

    2017-07-01

    Identify the environmental factors that influence stroke-survivors' reengagement in personally valued activities and determine what specific environmental factors are related to specific valued activity types. PubMed, CINAHL and PsycINFO were searched until June 2016 using multiple search-terms for stroke, activities, disability, and home and community environments. An integrated mixed-method systematic review of qualitative, quantitative and mixed-design studies was conducted. Two researchers independently identified relevant studies, assessed their methodological quality and extracted relevant findings. To validly compare and combine the various findings, all findings were classified and grouped by environmental category and level of evidence. The search yielded 4024 records; 69 studies were included. Most findings came from low-evidence-level studies such as single qualitative studies. All findings were consistent in that the following factors facilitated reengagement post-stroke: personal adapted equipment; accessible environments; transport; services; education and information. Barriers were: others' negative attitudes and behaviour; long distances and inconvenient environmental conditions (such as bad weather). Each type of valued activity, such as mobility or work, had its own pattern of environmental influences, social support was a facilitator to all types of activities. Although in many qualitative studies others' attitudes, behaviour and stroke-related knowledge were seen as important for reengagement, these factors were hardly studied quantitatively. A diversity of environmental factors was related to stroke-survivors' reengagement. Most findings came from low-evidence-level studies so that evidence on causal relationships was scarce. In future, more higher-level-evidence studies, for example on the attitudes of significant others, should be conducted.

  7. Comparing the environmental footprints of home-care and personal-hygiene products: the relevance of different life-cycle phases.

    Science.gov (United States)

    Koehler, Annette; Wildbolz, Caroline

    2009-11-15

    An in-depth life-cycle assessment of nine home-care and personal-hygiene products was conducted to determine the ecological relevance of different life-cycle phases and compare the environmental profiles of products serving equal applications. Using detailed data from industry and consumer-behavior studies a broad range of environmental impacts were analyzed to identify the main drivers in each life-cycle stage and potentials for improving the environmental footprints. Although chemical production significantly adds to environmental burdens, substantial impacts are caused in the consumer-use phase. As such, this research provides recommendations for product development, supply chain management, product policies, and consumer use. To reduce environmental burdens products should, for instance, be produced in concentrated form, while consumers should apply correct product dosages and low water temperatures during product application.

  8. A Comparison of Smokers' and Nonsmokers' Fruit and Vegetable Intake and Relevant Psychosocial Factors

    Science.gov (United States)

    McClure, Jennifer B.; Divine, George; Alexander, Gwen; Tolsma, Dennis; Rolnick, Sharon J.; Stopponi, Melanie; Richards, Julie; Johnson, Christine C.

    2009-01-01

    The authors examined the relation between smoking status and fruit and vegetable (FV) consumption among a population-based sample and examined differences in psychosocial factors that may influence diet and inform intervention efforts. The authors recruited adults (N = 2,540) from 5 US health plans to participate in a Web-based dietary intervention trial. At baseline, smokers ate fewer FV servings per day (p motivation, and intrinsic motivation for meeting daily FV recommendations. Fewer smokers expected that eating 5 FV servings a day would reduce their risk for diabetes (p = .02) or obesity (p = .008). Smokers are an important target group for dietary intervention. Intervention efforts should attempt to increase smokers' motivation and confidence in their abilities to change their eating patterns and educate them about the health benefits of eating FV. PMID:19297300

  9. Corticotropin-releasing factor peptide antagonists: design, characterization and potential clinical relevance.

    Science.gov (United States)

    Rivier, Jean E; Rivier, Catherine L

    2014-04-01

    Elusive for more than half a century, corticotropin-releasing factor (CRF) was finally isolated and characterized in 1981 from ovine hypothalami and shortly thereafter, from rat brains. Thirty years later, much has been learned about the function and localization of CRF and related family members (Urocortins 1, 2 and 3) and their 2 receptors, CRF receptor type 1 (CRFR1) and CRF receptor type 2 (CRFR2). Here, we report the stepwise development of peptide CRF agonists and antagonists, which led to the CRFR1 agonist Stressin1; the long-acting antagonists Astressin2-B which is specific for CRFR2; and Astressin B, which binds to both CRFR1 and CRFR2.This analog has potential for the treatment of CRF-dependent diseases in the periphery, such as irritable bowel syndrome. Copyright © 2013 Elsevier Inc. All rights reserved.

  10. Allergic contact dermatitis in childrenwhich factors are relevant? (review of the literature)

    DEFF Research Database (Denmark)

    de Waard-van der Spek, Flora B; Andersen, Klaus Ejner; Darsow, Ulf

    2013-01-01

    defined dermatitis on the lower legs. Clinical polymorphism of contact dermatitis to clothing may cause difficulties in diagnosing textile dermatitis. Toys are another potentially source of hapten exposure in children, especially from toy-cosmetic products such as perfumes, lipstick and eye shadow......Allergic Contact Dermatitis (ACD) in children is increasing. Sensitization to contact allergens can start in early infancy. The epidermal barrier is crucial for the development of sensitization and elicitation of ACD. Factors that may influence the onset of sensitization in children are atopic...... dermatitis, skin barrier defects and intense or repetitive contact with allergens. Topical treatment of ACD is associated with cutaneous sensitization, although the prevalence is not high. ACD because of haptens in shoes or shin guards should be considered in cases of persistent foot eruptions or sharply...

  11. Retrieving relevant factors with exploratory SEM and principal-covariate regression: A comparison.

    Science.gov (United States)

    Vervloet, Marlies; Van den Noortgate, Wim; Ceulemans, Eva

    2018-02-12

    Behavioral researchers often linearly regress a criterion on multiple predictors, aiming to gain insight into the relations between the criterion and predictors. Obtaining this insight from the ordinary least squares (OLS) regression solution may be troublesome, because OLS regression weights show only the effect of a predictor on top of the effects of other predictors. Moreover, when the number of predictors grows larger, it becomes likely that the predictors will be highly collinear, which makes the regression weights' estimates unstable (i.e., the "bouncing beta" problem). Among other procedures, dimension-reduction-based methods have been proposed for dealing with these problems. These methods yield insight into the data by reducing the predictors to a smaller number of summarizing variables and regressing the criterion on these summarizing variables. Two promising methods are principal-covariate regression (PCovR) and exploratory structural equation modeling (ESEM). Both simultaneously optimize reduction and prediction, but they are based on different frameworks. The resulting solutions have not yet been compared; it is thus unclear what the strengths and weaknesses are of both methods. In this article, we focus on the extents to which PCovR and ESEM are able to extract the factors that truly underlie the predictor scores and can predict a single criterion. The results of two simulation studies showed that for a typical behavioral dataset, ESEM (using the BIC for model selection) in this regard is successful more often than PCovR. Yet, in 93% of the datasets PCovR performed equally well, and in the case of 48 predictors, 100 observations, and large differences in the strengths of the factors, PCovR even outperformed ESEM.

  12. Source to sink transport and regulation by environmental factors

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    Remi eLemoine

    2013-07-01

    Full Text Available Source-to-sink transport of sugar is one of the major determinants of plant growth and relies on the efficient and controlled distribution of sucrose (and some other sugars such as raffinose and polyols across plant organs through the phloem. However, sugar transport through the phloem can be affected by many environmental factors that alter source/sink relationships. In this paper, we summarize current knowledge about the phloem transport mechanisms and review the effects of several abiotic (water and salt stress, mineral deficiency, CO2, light, temperature, air and soil pollutants and biotic (mutualistic and pathogenic microbes, viruses, aphids and parasitic plants factors. Concerning abiotic constraints, alteration of the distribution of sugar among sinks is often reported, with some sinks as roots favoured in case of mineral deficiency. Many of these constraints impair the transport function of the phloem but the exact mechanisms are far from being completely known. Phloem integrity can be disrupted (e.g. by callose deposition and under certain conditions, phloem transport is affected, earlier than photosynthesis. Photosynthesis inhibition could result from the increase in sugar concentration due to phloem transport decrease. Biotic interactions (aphids, fungi, viruses… also affect crop plant productivity. Recent breakthroughs have identified some of the sugar transporters involved in these interactions on the host and pathogen sides. The different data are discussed in relation to the phloem transport pathways. When possible, the link with current knowledge on the pathways at the molecular level will be highlighted.

  13. Differential environmental factors in anorexia nervosa: a sibling pair study.

    Science.gov (United States)

    Murphy, F; Troop, N A; Treasure, J L

    2000-06-01

    Previous studies have explored differences in psychosocial and familial factors between women who develop anorexia nervosa and those who do not. However, these studies have generally used between-group comparisons. This study looks at the environmental factors which may be antecedents of anorexia nervosa looking at sister pairs where one had anorexia nervosa and the other did not. A paired design was used to compare anorexic women with an unaffected sister on a number of background variables, including sibling interaction, parental care, peer group characteristics and other events unique to the individual. The Sibling Inventory of Differential Experience (SIDE) was used to determine non-shared environment. Out of an initial sample of 148 women with past or current anorexia nervosa, 28 were identified who had sisters with no reported history of eating disorders and who also consented to complete the questionnaire. Anorexic sisters perceived more maternal control and reported more antagonism towards and jealousy of their sisters than did unaffected sisters. In addition, anorexic women reported having had fewer friends and boyfriends than their sisters. These results confirm the perceived differences in background environment between women with and women without anorexia nervosa. These issues are discussed in relation to behavioural genetics, family dynamics and psychosexual development.

  14. [Analysis of the relevant factors for recurrent sudden sensorineural hearing loss].

    Science.gov (United States)

    Liang, H; Zhong, S X

    2016-09-07

    Objective: To investigate the possible factors related to recurrence and prognosis of sudden sensorineural hearing loss(SSNHL). Methods: Four hundred and ninety-five patients with unilateral sudden sensorineural hearing loss between January 2013 to April 2014 were analyzed retrospectively(34 patients lost to follow-up with a dropout rate of 6.87%). Twenty of the 495 patients were diagnosed as recurrent SSNHL and treated again in the same hospital. The data of the patients were summarized to analyze the related factors which might influence the recurrence and prognosis of SSNHL. Results: In the 20 patients with recurrent SSNHL, 19 had the second attack in same ear as the first attack, and the other one had in both ears. There were seven male patients, and thirteen female patients. Patients ranged in age from 24 to 77years, with a median age of 39.5 years. Types of hearing loss: low frequency in eight patients, high frequency in two patients, flat frequency in eight patients, total deafness in two patients, the types of the second attack in 17 patients were same as the first attack, only one patient was changed from total deafness to flat frequency, one case was changed from flat frequency to high frequency, one case changed from flat frequency to total deafness. The intervals between of the first attack time and the second attack time were 1-36 months with the median time of 3.5 months. After systemic oral and (or) transtympanic steroid treatment, recovered in three cases, effective in three cases and 14 cases invalid, the cure rate was 15%, and the total effective rate was 30%. There were statistically significant differences in the recovery rate(χ 2 =8.640, P vertigo and/or dizziness, with a history more than seven days, with hypertension or diabetes mellitus, and with a type of hearing loss except low frequency type, the treatment effect was invalid. The patients with hearing loss at low frequency had the best outcomes. The total effective rates were significant

  15. Prevalence of Disability and Relevant Risk Factors In Elderly Dwellers in Isfahan Province-2012

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    Zamane Vafaei

    2014-01-01

    Full Text Available Objectives: Due to the increasing elderly population in the country, this study was conducted to determine the level of disability and associated factors, in order to plan for the prevention of disability and reduce the effects of aging. Methods & Materials: This study was conducted through cross-sectional, descriptive analysis and cluster sampling method among 300 patients aged 60 years and older in 8 districts of 14 urban areas of Esfahan. The Data was collected through face to face interviews at elderly people's home. The data collection tool was a questionnaire consisted of two parts: The first section contained demographic, socioeconomic, disease and the needs of the studied population and the second part WHODAS (World Health Organization Disability Assessment Schedule standard questionnaire, from the World Health Organization resources. The data were analysed through descriptive and analytic statistics. Results: The mean age of the total study population were 71.4 years old, and the median age was 70 years. Among the studied population 15.7 had no disability and most of them (33.3% were suffering from low levels of disability. The highest rate of people without disabilities - regardless of employed people - reffered to cope and live with other people (63.3%. However, the highest rate of severe disability was related to the mobility and doing the daily duties (25.3%. Disability scores increased with age (r=0.4 and decreased significantly with income enhancement (r=-0.3. Moreover, women, widows, those who were living with people other than family, illiteracy and workers had a significantly more disability. Considering disorders and diseases, musculoskeletal disorders, urinary and faecal incontinence, speech disorder, brain stroke, ataxia, Alzheimer's, Parkinson's disease, cognitive and memory disorders were more severe disabilities. So that the mean disability score (out of 100 in patients with the musculoskeletal diseases was approximately

  16. Age factor relevant to the development of radiation pneumonitis in radiotherapy of lung cancer

    International Nuclear Information System (INIS)

    Koga, K.; Kusumoto, S.; Watanabe, K.; Nishikawa, K.; Harada, K.; Ebihara, H.

    1988-01-01

    The significance of age factor for the development of radiation pneumonitis is evaluated in 62 patients with lung cancer between 1977 and 1985. The younger group consists of those less than 70 years old and the elderly group of those 70 years old or more. Radiation doses ranged from 1.5 to 2 Gy, 3 to 5 times per week, therefore the delivered doses were converted to nominal single doses (rets dose). Severe radiation pneumonitis was more often observed in the elderly than in the younger regardless of radiation field size and chemotherapy (n.s.). The onset of radiation pneumonitis occurred earlier in a field size of 90 sq cm or more than in that of less than 90 sq cm in both age groups; there was no significant difference between the two age groups in each field size. The pneumonitis was more frequently noted with increasing rets dose in both age groups (n.s.) regardless of field size and chemotherapy. It is concluded that there is no significant difference in the development of radiation pneumonitis between the younger group and the elderly group, but the pneumonitis is inclined to be more severe in the latter

  17. Contributions to the determination of the noble metals gold, iridium, palladium, platinum, rhodium and application to environmentally relevant samples

    International Nuclear Information System (INIS)

    Zischka, M.

    1998-11-01

    The concentrations of noble metals in the environment are still very low (low ng/g and sub ng/g range), although they are emitted to an increasing extent as components of catalytic exhaust emission converters into the environment. The determination of these elements can be error prone even when the determinations are carried out by use of highly sensitive methods in combination with high performance sample preparation techniques. Accurate data with smallest possible measurement uncertainties are a prerequisite for the interpretation of the distribution of noble metals in the environment and their possible toxicological effects. Difficulties related to the determination of the noble metals could be the incomplete recovery after sample preparation, sample digestion and interferences arising in subsequent instrumental determination methods. For this reason two different sample decomposition methods in combination with powerful instrumental techniques are checked for suitability for the determination of the noble metals in environmentally relevant samples. Digestion methods under evaluation are the NiS fire assay and the leaching with aqua regia in closed vessels under high pressure and high temperature. The NiS fire assay provides pre-concentration of the noble-metals and matrix separation of most of the remaining matrix elements. Disadvantages of this method are the need for experienced analysts, the awkward handling and the time-consuming procedure. On the other hand leaching with aqua regia under high pressure at high temperatures is easy to handle and not time-consuming with the crucial disadvantage that neither a pre-concentration of the noble metals nor a matrix separation can be achieved. Investigated instrumental techniques are the ICP-AES (inductively coupled plasma atomic emission spectrometry) with an axially arranged plasma either with a cross-flow or with an ultrasonic nebulizer, the quadrupole ICP-MS (inductively coupled plasma mass spectrometry) and the

  18. The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress.

    Science.gov (United States)

    Miguel, Verónica; Cui, Julia Yue; Daimiel, Lidia; Espinosa-Díez, Cristina; Fernández-Hernando, Carlos; Kavanagh, Terrance J; Lamas, Santiago

    2018-03-20

    MicroRNAs (miRNAs) are important regulators of gene expression and define part of the epigenetic signature. Their influence on every realm of biomedicine is established and progressively increasing. The impact of environment on human health is enormous. Among environmental risk factors impinging on quality of life are those of chemical nature (toxic chemicals, heavy metals, pollutants, and pesticides) as well as those related to everyday life such as exposure to noise or mental and psychosocial stress. Recent Advances: This review elaborates on the relationship between miRNAs and these environmental risk factors. The most relevant facts underlying the role of miRNAs in the response to these environmental stressors, including redox regulatory changes and oxidative stress, are highlighted and discussed. In the cases wherein miRNA mutations are relevant for this response, the pertinent literature is also reviewed. We conclude that, even though in some cases important advances have been made regarding close correlations between specific miRNAs and biological responses to environmental risk factors, a need for prospective large-cohort studies is likely necessary to establish causative roles. Antioxid. Redox Signal. 28, 773-796.

  19. Modulation of the Genome and Epigenome of Individuals Susceptible to Autism by Environmental Risk Factors

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    Costas Koufaris

    2015-04-01

    Full Text Available Diverse environmental factors have been implicated with the development of autism spectrum disorders (ASD. Genetic factors also underlie the differential vulnerability to environmental risk factors of susceptible individuals. Currently the way in which environmental risk factors interact with genetic factors to increase the incidence of ASD is not well understood. A greater understanding of the metabolic, cellular, and biochemical events involved in gene x environment interactions in ASD would have important implications for the prevention and possible treatment of the disorder. In this review we discuss various established and more alternative processes through which environmental factors implicated in ASD can modulate the genome and epigenome of genetically-susceptible individuals.

  20. Relevant factors affecting the outcome of ultrasound guided foam sclerotherapy of the great saphenous vein

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    Giorgio Falaschi

    2013-09-01

    Full Text Available Ultrasound guided foam sclerotherapy (UGFS constitutes a valid ablative treatment for superficial vein diseases for the great saphenous vein (GSV, but no standardized protocol for its execution has yet been defined. Different variable factors involved in this procedure influence the final outcome and clinical results. The aim of our study was to analyze the respective influence on efficacy and side effects of three variable factors (foam volume, foam concentration, and contact time between the foam and the endothelium for UGFS procedures for GSV insufficiency in order to select the best protocol for treatment. A retrospective analysis was made of UGFS procedures (190 patients, 201 legs performed for GSV insufficiency in our institute from January 2007 to January 2010. All great saphenous veins included in our study exhibited a trans-ostial reflux and caliber range was 7-11 mm. In all cases, foam was prepared according to the Tessari method, using polidocanol (POL and a gas mixture of CO2 (70% and filtered room air (30%, in a proportion of 1:4. A single injection procedure in the GSV was performed under Doppler ultrasound guidance at mid to lower third of the thigh. Legs were randomly assigned to one of three different treatment protocols: - Group A (71 legs: POL 3%, mean foam volume 4.5 cc, intermittent groin pressure 5 min, supine bed rest 10 min; - Group B (61 legs: POL 2%, mean foam volume 9 cc, intermittent groin pressure 5 min, supine bed rest 10 min; - Group C (69 legs: POL 2%, mean foam volume 9 cc, continuous groin pressure 5 min followed by intermittent groin pressure 5 min, continuous leg compression 5 min, supine bed rest 10 min. Efficacy of treatment and occurrence of side effects were evaluated in each group at two weeks and again at two years after the procedure and the cumulative results compared. Analysis of outcomes did not show any significant difference between the complete obliteration rate (P=0.825 or occurrence of local

  1. The Potential Risk Factors Relevant to Lateral Epicondylitis by Wrist Coupling Posture.

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    Su-Ya Lee

    Full Text Available The use of awkward wrist postures and unskilled techniques might induce lateral epicondylitis. This study thus investigated the effects of wrist deviation combined with extension and movement velocity on the dynamic performances of the wrist muscles during the coupling posture via a custom-made bi-planar isokinetic dynamometer. Thirty subjects were recruited to perform the isokinetic testing. We measured the muscle strengths and activities for the wrist extensors and flexors during concentric and eccentric contractions at three movement velocities, 30°s-1, 90°s-1, and 180°s-1, combined with three wrist postures, neutral position (NP, radial deviation (RD, and ulnar deviation (UD. The root mean square (RMS of the electromyographic signal in the extensor digitorum communis (EDC, normalized peak torque of extensors, and ratio of normalized peak torque between wrist extensors and flexors, were all greater in the NP than RD and UD in both contractions. The ratio of RMS between EDC and flexor digitorum superficialis (FDS had a significantly greater value in RD than UD during the concentric contraction. The EDC showed significantly higher activity at the fast velocity in both contractions. Nevertheless, a significantly higher RMS of the electromyographic signal between EDC and FDS and the ratio of strength between wrist extensors and flexors were found at slow velocity in both contractions. The wrist deviation combined with extension and movement velocity of the wrist joint should thus be considered as influential factors which might alter the dynamic performances, and may result in further injury of the elbow joint.

  2. Environmental Factors Associated with Psychotropic Drug Use in Brazilian Nightclubs.

    Science.gov (United States)

    Carlini, Claudia; Andreoni, Solange; Sanchez, Zila M

    2017-08-01

    The purpose of this study was to identify environmental factors associated with patterns of psychotropic drug use in nightclubs. Mixed methods were used to investigate psychotropic drugs consumption among patrons of 31 nightclubs in São Paulo, Brazil. A total of 1822 patrons at the entrance and exit of the venues and 30 staff members of the nightclubs were interviewed. The observational data were collected through 307 h of observational research using a structured guide to register environmental measures. Psychotropic drug use in nightclubs was classified into three categories (1: no drugs; 2: legal drugs [e.g., alcohol and tobacco]; or 3: illicit drugs regardless of alcohol and tobacco use). Illicit drugs used were self-reported by patrons, and alcohol use was measured using a breathalyzer. The data were analyzed in clusters using correlated multinomial logistic regression models. The following environmental variables were associated with illicit drug use in nightclubs: all-you-can-drink service (adjusted odds ratio (aOR) = 11.84, 95%CI [4.06;34.57]) and light effects, such as laser and "disco lights" (aOR = 24.49, 95%CI [8.48;70.77]). The number of bouncers per capita × 100 and the presence of two or more dance floors were inversely associated with the use of illicit drugs (aOR = 0.26, 95%CI [0.11;0.65], and aOR = 0.13, 95%CI [0.06;0.29], respectively). Legal drug use was associated with all-you-can-drink service (aOR = 2.17, 95%CI [1.43;5.04]), the presence of two or more dance floors (aOR = 2.06, 95%CI [1.40;3.05]), and the number of bouncers per capita × 100 (aOR = 1.39, 95%CI [1.22;1.59]). These findings suggest that this is a multivariate phenomenon that would require an integrated approach involving the venue owners, staff members, patrons, local governments, and law enforcement agencies.

  3. Genetic and environmental factors influencing the Placental Growth Factor (PGF variation in two populations.

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    Rossella Sorice

    Full Text Available Placental Growth Factor (PGF is a key molecule in angiogenesis. Several studies have revealed an important role of PGF primarily in pathological conditions (e.g.: ischaemia, tumour formation, cardiovascular diseases and inflammatory processes suggesting its use as a potential therapeutic agent. However, to date, no information is available regarding the genetics of PGF variability. Furthermore, even though the effect of environmental factors (e.g.: cigarette smoking on angiogenesis has been explored, no data on the influence of these factors on PGF levels have been reported so far. Here we have first investigated PGF variability in two cohorts focusing on non-genetic risk factors: a study sample from two isolated villages in the Cilento region, South Italy (N=871 and a replication sample from the general Danish population (N=1,812. A significant difference in PGF mean levels was found between the two cohorts. However, in both samples, we observed a strong correlation of PGF levels with ageing and sex, men displaying PGF levels significantly higher than women. Interestingly, smoking was also found to influence the trait in the two populations, although differently. We have then focused on genetic risk factors. The association between five single nucleotide polymorphisms (SNPs located in the PGF gene and the plasma levels of the protein was investigated. Two polymorphisms (rs11850328 and rs2268614 were associated with the PGF plasma levels in the Cilento sample and these associations were strongly replicated in the Danish sample. These results, for the first time, support the hypothesis of the presence of genetic and environmental factors influencing PGF plasma variability.

  4. Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications

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    John Ong

    2018-03-01

    Full Text Available Summary: Use of hepatocytes derived from induced pluripotent stem cells (i-Heps is limited by their functional differences in comparison with primary cells. Extracellular niche factors likely play a critical role in bridging this gap. Using image-based characterization (high content analysis; HCA of freshly isolated hepatocytes from 17 human donors, we devised and validated an algorithm (Hepatocyte Likeness Index; HLI for comparing the hepatic properties of cells against a physiological gold standard. The HLI was then applied in a targeted screen of extracellular niche factors to identify substrates driving i-Heps closer to the standard. Laminin 411, the top hit, was validated in two additional induced pluripotent stem cell (iPSC lines, primary tissue, and an in vitro model of α1-antitrypsin deficiency. Cumulatively, these data provide a reference method to control and screen for i-Hep differentiation, identify Laminin 411 as a key niche protein, and underscore the importance of combining substrates, soluble factors, and HCA when developing iPSC applications. : Rashid and colleagues demonstrate the utility of a high-throughput imaging platform for identification of physiologically relevant extracellular niche factors to advance i-Heps closer to their primary tissue counterparts. The extracellular matrix (ECM protein screen identified Laminin 411 as an important niche factor facilitating i-Hep-based disease modeling in vitro. Keywords: iPS hepatocytes, extracellular niche, image-based screening, disease modeling, laminin

  5. Demographic and Environmental Factors Associated with Mental Health: A Cross-Sectional Study

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    Jayeun Kim

    2017-04-01

    Full Text Available Relevant demographic and environmental conditions need to be understood before tailoring policies to improve mental health. Using community health survey data from 25 communities in Seoul, 2013, cross-sectional associations between mental health and community level environments were assessed. Mental health outcomes (self-rated stress levels (SRS and depressive symptoms (DS were analyzed. Community environmental factors included green space, green facilities, and annual PM10 level (AnnPM10; socio-demographic factors included sex, age, education, labor market participation, comorbidity, sleep hours, physical activity, smoking, and drinking. A total of 23,139 people with the following characteristics participated: men (44.2%; age groups 19−39 (36.0%, 40−59 (39.4%, 60−74 (19.2%, and 75+ (5.4%. Women had higher odds ratios (OR for SRS [OR 1.22, 95% Confidence interval (CI 1.17–1.27] and DS [OR 1.55, 95% CI 1.42–1.71]. Regular physical activity predicted SRS [OR 0.90, 95% CI 0.84–0.95] and DS [OR 0.98, 95% CI 0.88–1.10]; current smoking and drinking were adversely associated with both SRS and DS. Higher accessibility to green space (Q4 was inversely associated with DS [OR 0.89, 95% CI 0.81−0.97] compared to lower accessibility (Q1. AnnPM10, annual levels for particles of aerodynamic diameter <10 µm (PM10, among communities was associated with poorer SRS [OR 1.02, 95% CI 1.00–1.04] by 10 μg/m3 increases. Therefore, both demographic and environmental factors should be considered to understand mental health conditions among the general population.

  6. THE IMPLICATIONS OF THE ENVIRONMENTAL MARKETING FACTORS WITHIN THE LIGHTING SOURCES AND FIXTURES MARKET

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    Cornelia Denisa IVAN

    2014-10-01

    Full Text Available Every company functionality is influenced by the environment in which they operate. In the present economical environment, the enterprise cannot survive in a market based on competition without continuously struggling to keep informed about the surroundings. The aim of this paper is to identify at the right time the new opportunities of development and also the threats which may compromise the company’s results or, even worse, may put the company in a difficult position. This research is important for the development of the enterprise’s strategies. The analysis of the marketing environment varies according to the field of the enterprise’s activity. Therefore, this article is a case study that examines the influence of environmental factors on the lighting sources and fixtures market (LSF. The originality and quality of the case stem from the attempt to analyze a dynamic field characterized by the buyers’ change of preferences and their receptivity to what is new, which requires increased consideration for the influence of environmental factors. The challenges of analyzing this domain consist of the transformations that take place with the new lighting technologies proposed by manufacturers to meet the users’ preferences. This review is relevant to the LSF market, but it can also be extended to other related fields.

  7. Delayed-Type Hypersensitivity to Metals of Environmental Burden in Patients with Takotsubo Syndrome - Is There a Clinical Relevance?

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    Jan Manousek

    Full Text Available Takotsubo syndrome (TS is a heart condition characterised by a sudden transient left ventricular dysfunction; its pathophysiology is probably associated with elevated levels of catecholamines but the exact mechanism is not known as yet. Literature and clinical experience suggest that TS affects persons with various comorbidities. This pilot work aims to evaluate the frequency of comorbidities with potential pathological immune reactivity, and to evaluate the potential association between TS and hypersensitivity to metals assessed by LTT-MELISA®.A total of 24 patients (23 women, 1 man with a history of TS attack and 27 healthy controls were evaluated. Hypersensitivity was evaluated by a lymphocyte transformation test (LTT-MELISA®; a questionnaire of environmental burden was used to select evaluated metals. A total of 19 patients (79% had at least one condition that might potentially be associated with pathological immune reactivity (autoimmune thyroid disease, drug allergy, bronchial asthma, cancer, contact dermatitis, rheumatoid arthritis. Hypersensitivity to metals was identified significantly more frequently in TS patients than in healthy controls (positive reaction to at least one metal was identified in 95.8% of TS patients and in 59.3% of controls; p = 0.003; the difference was statistically significant for mercury (45.8% and 14.8%, respectively; p = 0.029.Our work shows that conditions with pathological immune reactivity occur frequently in TS patients, and our data suggest a possible association between TS and hypersensitivity to metals (mercury in particular evaluated by LTT-MELISA®. We also suggest that apart from the triggering stress factor, potential existence of other serious conditions should be considered when taking medical history of TS patients.

  8. Delayed-Type Hypersensitivity to Metals of Environmental Burden in Patients with Takotsubo Syndrome – Is There a Clinical Relevance?

    Science.gov (United States)

    Manousek, Jan; Stejskal, Vera; Kubena, Petr; Jarkovsky, Jiri; Nemec, Petr; Lokaj, Petr; Dostalova, Ludmila; Zadakova, Andrea; Pavlusova, Marie; Benesova, Klara; Kala, Petr; Miklik, Roman; Spinar, Jindrich; Parenica, Jiri

    2016-01-01

    Objective Takotsubo syndrome (TS) is a heart condition characterised by a sudden transient left ventricular dysfunction; its pathophysiology is probably associated with elevated levels of catecholamines but the exact mechanism is not known as yet. Literature and clinical experience suggest that TS affects persons with various comorbidities. This pilot work aims to evaluate the frequency of comorbidities with potential pathological immune reactivity, and to evaluate the potential association between TS and hypersensitivity to metals assessed by LTT-MELISA®. Methodology, Results A total of 24 patients (23 women, 1 man) with a history of TS attack and 27 healthy controls were evaluated. Hypersensitivity was evaluated by a lymphocyte transformation test (LTT-MELISA®); a questionnaire of environmental burden was used to select evaluated metals. A total of 19 patients (79%) had at least one condition that might potentially be associated with pathological immune reactivity (autoimmune thyroid disease, drug allergy, bronchial asthma, cancer, contact dermatitis, rheumatoid arthritis). Hypersensitivity to metals was identified significantly more frequently in TS patients than in healthy controls (positive reaction to at least one metal was identified in 95.8% of TS patients and in 59.3% of controls; p = 0.003); the difference was statistically significant for mercury (45.8% and 14.8%, respectively; p = 0.029). Conclusion Our work shows that conditions with pathological immune reactivity occur frequently in TS patients, and our data suggest a possible association between TS and hypersensitivity to metals (mercury in particular) evaluated by LTT-MELISA®. We also suggest that apart from the triggering stress factor, potential existence of other serious conditions should be considered when taking medical history of TS patients. PMID:27824862

  9. Environmental market factors associated with physician career satisfaction.

    Science.gov (United States)

    Mazurenko, Olena; Menachemi, Nir

    2012-01-01

    Previous research has found that physician career satisfaction is declining, but no study has examined the relationship between market factors and physician career satisfaction. Using a theoretical framework, we examined how various aspects of the market environment (e.g., munificence, dynamism, complexity) are related to overall career satisfaction. Nationally representative data from the 2008 Health Tracking Physician Survey were combined with environmental market variables from the 2008 Area Resource File. After controlling for physician and practice characteristics, at least one variable each representing munificence, dynamism, and complexity was associated with satisfaction. An increase in the market number of primary care physicians per capita was positively associated with physician career satisfaction (OR = 2.11, 95% CI: 1.13 to 3.9) whereas an increase in the number of specialists per capita was negatively associated with physician satisfaction (OR = 0.68, 95% CI: 0.48 to 0.97). Moreover, an increase in poverty rates was negatively associated with physician career satisfaction (OR = 0.95, 95% CI: 0.91 to 1.01). Lastly, physicians practicing in states with a malpractice crisis (OR = 0.81, 95% CI: 0.68 to 0.96) and/or those who perceived high competition in their markets (OR = 0.76, 95% CI: 0.61 to 0.95) had lower odds of being satisfied. A better understanding of an organization's environment could assist healthcare managers in shaping their policies and strategies to increase physician satisfaction.

  10. Occurrence of clinical mastitis and environmental factors favoring its incidence

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    Elisa Junqueira Oliveira

    2013-02-01

    Full Text Available The objective of this study was to evaluate the frequency of clinical mastitis (CM, in high production Holstein cows, as well as the environmental factors that favoring its incidence. The average milk production of 305 days, according to the class of mastitis was estimated by the method of least squares. The frequencies of clinical mastitis (CM events were analyzed according to the calving sequences (1-6, year of calving, season and stage of lactation, and infected quarter (right anterior, left anterior, right posterior, left posterior. The frequency of CM ranged from 11.39% in the first calving to 21.18% in the third. 58.56% of mastitis cases occurred in the wet season, and 41.44% occurred in the dry season. The final lactation stage (200 to 300 days was the period with the highest occurrence of CM (45.33%. The quarter posterior had a higher frequency CM (54.25%. Animals with higher levels of milk production of 305 days showed highest occurrence of CM. We must find a balance between milk production and mastitis in order to increase profitability. The study of the periods of greatest frequency clinical mastitis events is essential for dairy farming, to direct a program to control this disease.

  11. Safety analysis factors for environmental restoration and decontamination and decommissioning

    International Nuclear Information System (INIS)

    Ellingson, D.R.

    1993-04-01

    Environmental restoration (ER) and facility decontamination/decommissioning (D ampersand D) operations can be grouped into two general categories. ''Nonstationary cleanup'' or simply ''cleanup'' activities are where the operation must relocate to the site of new contaminated material at the completion of each task (i.e., the operation moves to the contaminated material). ''Stationary production'' or simply ''production'' activities are where the contaminated material is moved to a centralized location (i.e., the contaminated material is moved to the operation) for analysis, sorting, treatment, storage, and disposal. This paper addresses the issue of nonstationary cleanup design. The following are the specific assigned action items: Collect and compile a list of special safety-related ER/D ampersand D design factors, especially ones that don't follow DOE Order 6430.1A requirements. Develop proposal of what makes sense to recommend to designers; especially consider recommendations for short-term projects. Present proposal at the January meeting. To achieve the action items, applicable US Department of Energy (DOE) design requirements, and cleanup operations and differences from production activities are reviewed and summarized; basic safety requirements influencing design are summarized; and finally, approaches, considerations, and methods for safe, cost-effective design of cleanup activities are discussed

  12. The Relationships between Environmental Factors and Violent Behaviors in Adolescent Students of Isfahan, Iran.

    Science.gov (United States)

    Omidi, Razieh; Heidari, Kamal; Davari, Hossein; Espanani, Morteza; Poursalehi, Mojtaba; Naeini, Shokooh Eghtedari; Rastkerdar, Zeinabsadat; Azizi, Amir; Zakizadeh, Mohammadreza

    2014-12-01

    Violence is a global issue that has received considerable attention during recent years. Available research has suggested various factors, mostly family and social factors, to possibly affect violence. As previous studies have not examined the relationship between these factors and violent behaviors in adolescents, this study aimed to assess the relationship between environmental factors and violence in adolescents. This descriptive, correlational research used cluster sampling to select 5500 adolescent students from Isfahan Province (Iran). Data were collected through a 21-item researcher-made questionnaire. The questionnaire was modified according to the relevant experts' opinions and had Cronbach's alpha of 0.82. The collected data were analyzed by applying multiple regression analysis in SPSS (SPSS Inc., Chicago, IL, USA). Most participants (89.1%) lived in urban areas and about half (49.8%) of them were female. Linear regression test showed violent behaviors to have significant, inverse relationships with love and affection in the family (β = -0.097; P drama and comedy movies (β = -0.128; P movies (β =0.129; P movies β =0.043; P drama movies) in the family to reduce violent behaviors in adolescents. In contrast, aggressive behaviors in the family, watching crime, police, and action movies were found to increase violent behaviors in adolescents.

  13. 78. Environmental air pollution: A new emerging factor for coronary artery disease

    Directory of Open Access Journals (Sweden)

    S.A. Meo

    2016-07-01

    Conclusion: Environmental pollution exert detrimental effects on the heart. The researchers and physicians must consider the environmental pollution as an emerging factor in the development of coronary artery disease.

  14. Human and bovine viruses in the Milwaukee River watershed: Hydrologically relevant representation and relations with environmental variables

    Energy Technology Data Exchange (ETDEWEB)

    Corsi, S.R., E-mail: srcorsi@usgs.gov [U.S. Geological Survey, Wisconsin Water Science Center, Middleton, WI 53562 (United States); Borchardt, M.A.; Spencer, S.K. [U.S. Department of Agriculture, Agricultural Research Service, 2615 Yellowstone Dr., Marshfield, WI 54449 (United States); Hughes, P.E.; Baldwin, A.K. [U.S. Geological Survey, Wisconsin Water Science Center, Middleton, WI 53562 (United States)

    2014-08-15

    To examine the occurrence, hydrologic variability, and seasonal variability of human and bovine viruses in surface water, three stream locations were monitored in the Milwaukee River watershed in Wisconsin, USA, from February 2007 through June 2008. Monitoring sites included an urban subwatershed, a rural subwatershed, and the Milwaukee River at the mouth. To collect samples that characterize variability throughout changing hydrologic periods, a process control system was developed for unattended, large-volume (56–2800 L) filtration over extended durations. This system provided flow-weighted mean concentrations during runoff and extended (24-h) low-flow periods. Human viruses and bovine viruses were detected by real-time qPCR in 49% and 41% of samples (n = 63), respectively. All human viruses analyzed were detected at least once including adenovirus (40% of samples), GI norovirus (10%), enterovirus (8%), rotavirus (6%), GII norovirus (1.6%) and hepatitis A virus (1.6%). Three of seven bovine viruses analyzed were detected including bovine polyomavirus (32%), bovine rotavirus (19%), and bovine viral diarrhea virus type 1 (5%). Human viruses were present in 63% of runoff samples resulting from precipitation and snowmelt, and 20% of low-flow samples. Maximum human virus concentrations exceeded 300 genomic copies/L. Bovine viruses were present in 46% of runoff samples resulting from precipitation and snowmelt and 14% of low-flow samples. The maximum bovine virus concentration was 11 genomic copies/L. Statistical modeling indicated that stream flow, precipitation, and season explained the variability of human viruses in the watershed, and hydrologic condition (runoff event or low-flow) and season explained the variability of the sum of human and bovine viruses; however, no model was identified that could explain the variability of bovine viruses alone. Understanding the factors that affect virus fate and transport in rivers will aid watershed management for minimizing

  15. Human and bovine viruses in the Milwaukee River watershed: Hydrologically relevant representation and relations with environmental variables

    International Nuclear Information System (INIS)

    Corsi, S.R.; Borchardt, M.A.; Spencer, S.K.; Hughes, P.E.; Baldwin, A.K.

    2014-01-01

    To examine the occurrence, hydrologic variability, and seasonal variability of human and bovine viruses in surface water, three stream locations were monitored in the Milwaukee River watershed in Wisconsin, USA, from February 2007 through June 2008. Monitoring sites included an urban subwatershed, a rural subwatershed, and the Milwaukee River at the mouth. To collect samples that characterize variability throughout changing hydrologic periods, a process control system was developed for unattended, large-volume (56–2800 L) filtration over extended durations. This system provided flow-weighted mean concentrations during runoff and extended (24-h) low-flow periods. Human viruses and bovine viruses were detected by real-time qPCR in 49% and 41% of samples (n = 63), respectively. All human viruses analyzed were detected at least once including adenovirus (40% of samples), GI norovirus (10%), enterovirus (8%), rotavirus (6%), GII norovirus (1.6%) and hepatitis A virus (1.6%). Three of seven bovine viruses analyzed were detected including bovine polyomavirus (32%), bovine rotavirus (19%), and bovine viral diarrhea virus type 1 (5%). Human viruses were present in 63% of runoff samples resulting from precipitation and snowmelt, and 20% of low-flow samples. Maximum human virus concentrations exceeded 300 genomic copies/L. Bovine viruses were present in 46% of runoff samples resulting from precipitation and snowmelt and 14% of low-flow samples. The maximum bovine virus concentration was 11 genomic copies/L. Statistical modeling indicated that stream flow, precipitation, and season explained the variability of human viruses in the watershed, and hydrologic condition (runoff event or low-flow) and season explained the variability of the sum of human and bovine viruses; however, no model was identified that could explain the variability of bovine viruses alone. Understanding the factors that affect virus fate and transport in rivers will aid watershed management for minimizing

  16. FTIR spectroscopic studies of bacterial cellular responses to environmental factors, plant-bacterial interactions and signalling

    OpenAIRE

    Kamnev, Alexander A.

    2008-01-01

    Modern spectroscopic techniques are highly useful in studying diverse processes in microbial cells related to or incited by environmental factors. Spectroscopic data for whole cells, supramolecular structures or isolated cellular constituents can reflect structural and/or compositional changes occurring in the course of cellular metabolic responses to the effects of pollutants, environmental conditions (stress factors); nutrients, signalling molecules (communication factors), etc. This inform...

  17. The Research for the Greenhouse Water Evaporation Based on the Environmental Factors

    OpenAIRE

    Lili Ma; Chaoxing He; Zhixin Wang

    2013-01-01

    To guide the greenhouse precision irrigation, influenced by the environmental factors, based on the definite plant, the greenhouse water evaporation characteristics are studied. The qualitative and the quantitative relationships between the environmental factors and the greenhouse water evaporation are probed into which will provide the theoretical basis for the water management of the facilities horticulture. Establishing the quantitative relations between the environmental factors and the w...

  18. Prediction of Adsorption Equilibrium of VOCs onto Hyper-Cross-Linked Polymeric Resin at Environmentally Relevant Temperatures and Concentrations Using Inverse Gas Chromatography.

    Science.gov (United States)

    Jia, Lijuan; Ma, Jiakai; Shi, Qiuyi; Long, Chao

    2017-01-03

    Hyper-cross-linked polymeric resin (HPR) represents a class of predominantly microporous adsorbents and has good adsorption performance toward VOCs. However, adsorption equilibrium of VOCs onto HPR are limited. In this research, a novel method for predicting adsorption capacities of VOCs on HPR at environmentally relevant temperatures and concentrations using inverse gas chromatography data was proposed. Adsorption equilibrium of six VOCs (n-pentane, n-hexane, dichloromethane, acetone, benzene, 1, 2-dichloroethane) onto HPR in the temperature range of 403-443 K were measured by inverse gas chromatography (IGC). Adsorption capacities at environmentally relevant temperatures (293-328 K) and concentrations (P/P s = 0.1-0.7) were predicted using Dubinin-Radushkevich (DR) equation based on Polany's theory. Taking consideration of the swelling properties of HPR, the volume swelling ratio (r) was introduced and r·V micro was used instead of V micro determined by N 2 adsorption data at 77 K as the parameter q 0 (limiting micropore volume) of the DR equation. The results showed that the adsorption capacities of VOCs at environmentally relevant temperatures and concentrations can be predicted effectively using IGC data, the root-mean-square errors between the predicted and experimental data was below 9.63%. The results are meaningful because they allow accurate prediction of adsorption capacities of adsorbents more quickly and conveniently using IGC data.

  19. Relevant factors for the voting decision in the 2002 presidential election: An analysis of the ESEB (Brazilian Electoral Study

    Directory of Open Access Journals (Sweden)

    Yan Carreirão

    2007-03-01

    Full Text Available The article investigates some of the most relevant factors for the voting de- cision in the 2002 presidential election by testing some of the main hypotheses about electoral behaviour in the country by means of logistic regression analyses based on data from the ESEB (Brazilian Electoral Study, a post-electoral survey conducted on a national sample of voters. In the models, taken as a whole, politi- cal opinions did not have much weight in the voting decision. Furthermore, they are unable to “explain” a very large share of voters’ positioning on a left-right scale or on a scale of voters’ “party sentiments”. All these “political” variables taken as a whole, in turn, “explain” only part of the evaluations that voters make of the government’s performance. The analysis shows that Brazilian voters’ voting deci- sion seems rather varied, since some variables were shown to be relevant to “ex- plain” the vote for a candidate, but not for the others. The variables shown to be more frequent (for all four candidates analysed and with more considerable weight were: voters’ religion, their “party sentiments”, their positioning on a left-right scale, the evaluations made of the then current government (in actual fact impor- tant only for the vote for Serra, the government’s candidate and the candidates’ attributes (especially “reliability” and “preparedness/competence”.

  20. Rapid population growth and environmental degradation: ultimate versus proximate factors.

    Science.gov (United States)

    Shaw, R P

    1989-01-01

    This philosophical review of 2 arguments about responsibility for and solutions to environmental degradation concludes that both sides are correct: the ultimate and the proximal causes. Ultimate causes of pollution are defined as the technology responsible for a given type of pollution, such as burning fossil fuel; proximate causes are defined as situation-specific factors confounding the problem, such as population density or rate of growth. Commoner and others argue that developed countries with low or negative population growth rates are responsible for 80% of world pollution, primarily in polluting technologies such as automobiles, power generation, plastics, pesticides, toxic wastes, garbage, warfaring, and nuclear weapons wastes. Distortionary policies also contribute; examples are agricultural trade protection, land mismanagement, urban bias in expenditures, and institutional rigidity., Poor nations are responsible for very little pollution because poverty allows little waste or expenditures for polluting, synthetic technologies. The proximal causes of pollution include numbers and rate of growth of populations responsible for the pollution. Since change in the ultimate cause of pollution remains out of reach, altering the numbers of polluters can make a difference. Predictions are made for proportions of the world's total waste production, assuming current 1.6 tons/capita for developed countries and 0.17 tons/capita for developing countries. If developing countries grow at current rates and become more wealthy, they will be emitting half the world's waste by 2025. ON the other hand, unsustainable population growth goes along with inadequate investment in human capital: education, health, employment, infrastructure. The solution is to improve farming technologies in the 117 non-self-sufficient countries, fund development in the most unsustainable enclaves of growing countries, break institutionalized socio-political rigidity in these enclaves, and focus on

  1. Factors Influencing the Desire To Take Environmental Action in Communities.

    Science.gov (United States)

    Pruneau, Diane; Chouinard, Omer; Musafiri, Jean-Pierre; IsaBelle, Claire

    In a coastal community, four social groups were chosen to participate in various educational programs designed to promote their desire to take environmental action. At the end of these educational programs, conducted by a scientist and an environmental educator, the participants were invited to get involved in the resolution of an environmental…

  2. Solar Program Assessment: Environmental Factors - Fuels from Biomass.

    Science.gov (United States)

    Energy Research and Development Administration, Washington, DC. Div. of Solar Energy.

    The purpose of this report is to present and prioritize the major environmental issues associated with the further development of biomass production and biomass conversion systems. To provide a background for this environmental analysis, the basic concepts of the technology are reviewed, as are resource requirements. The potential effects of this…

  3. Solar Program Assessment: Environmental Factors - Ocean Thermal Energy Conversion.

    Science.gov (United States)

    Energy Research and Development Administration, Washington, DC. Div. of Solar Energy.

    This report presents the environmental problems which may arise with the further development of Ocean Thermal Energy Conversion, one of the eight Federally-funded solar technologies. To provide a background for this environmental analysis, the history and basic concepts of the technology are reviewed, as are its economic and resource requirements.…

  4. Relationship between continuous state factors and sustainability factors in the economic, social and environmental dimensions

    Directory of Open Access Journals (Sweden)

    Gabriel Moreira Campos

    2013-12-01

    Full Text Available This article aims to explain the relationship of the main factors of the continuous state and sustainability of companies operating in Brazil, in its economic, social and environmental, and test the strength of this relationship. Accordingly, we performed an extensive literature review in works for national and international basis, the procedures adopted in order to answer the research question posed. Among the aspects that form the sustainable development and sustainability issues, there is the demand by developing metrics that allow accurate measurement of the degree of sustainable development and sustainability of the planet, nations and other organizations, such as companies. Were cited works that address issues related to the companies’ continuous state, studies that dealt with corporate sustainability and empirical research on key factors of sustainability of the sample companies. Also, quantified the strength of the relationship between the main factors of the continuous state and sustainability of a sample of 49 companies operating in Brazil, by employing the technique of Canonical Correlation for the period 2006 to 2010. The results confirmed the existence of a relationship between the main factors of the continuous state and sustainability of businesses as well as the intensity of this relationship.

  5. A review of occupational safety and health issues relevant to the Environmental Restoration Program: Selected case histories and associated issues

    International Nuclear Information System (INIS)

    Lesperance, A.M.; Siegel, M.R.; McKinney, M.C.

    1994-08-01

    Since the 1940s, US Department of Energy (DOE) sites have been used for nuclear materials processing and production, warhead testing, and weapons research and development. These activities have resulted in extensive environmental contamination. DOE has established a goal to cleanup and restore the groundwater, soils, sediments, and surface water at its facilities across the nation. To achieve this goal, many workers will be needed to conduct the cleanup. These workers will need training and will be required to follow occupational safety and health (OSH) regulations and guidelines. Compliance with the OSH regulations and guidelines will have an anomous influence on the schedule, money, and technology needed for environmental restoration. Therefore, one area that must be considered in the early stages of long-term planning is the impact of OSH issues on the environmental restoration process. The DOE Office of Environmental Restoration and Waste Management has requested that the Pacific Northwest Laboratory (PNL) investigate the impact of these issues on the environmental restoration process

  6. Applicable or relevant and appropriate requirements (ARARs) for remedial actions at the Portsmouth Gaseous Diffusion Plant: A compendium of environmental laws and guidance

    International Nuclear Information System (INIS)

    Houlberg, L.M.; Eaton, L.A.; Martin, J.A.; McDonald, E.P.; Etnier, E.L.

    1992-02-01

    Section 121 of the Comprehensive Environmental Response, Compensation, and Liability Act of 1990 (CERCLA) specifies that remedial actions for cleanup of hazardous substances must comply with applicable or relevant and appropriate requirements (ARARs) or standards under federal and state environmental laws. Although the US Department of Energy (DOE) Portsmouth Gaseous Diffusion Plant (PORTS) has not at this time been proposed for inclusion on the US Environmental Protection Agency National Priorities List, under Sect. I of an administrative consent order signed by DOE and the US Environmental Protection Agency on September 29, 1989, effective October 4, 1989, any necessary response actions at PORTS stipulated in the administrative consent order must be performed in a manner consistent with the Resource Conservation and Recovery Act of 1976 and CERCLA. Section 121 of CERCLA calls for the preparation of a draft listing of all ARARs. This report supplies a preliminary list of available federal and state ARARs that might be considered for remedial response at PORTS. A description of the terms ''applicable'' and ''relevant and appropriate'' is provided, as well as definitions of chemical-, location-, and action-specific ARARs. ARARs promulgated by the federal government and by the state of Ohio are listed in tables. In addition, the major provisions of the Resource Conservation and Recovery Act, Safe Drinking Water Act, Clean Water Act, and other acts, as they apply to hazardous waste cleanup, are discussed

  7. Natural variability of biochemical biomarkers in the macro-zoobenthos: Dependence on life stage and environmental factors.

    Science.gov (United States)

    Scarduelli, Lucia; Giacchini, Roberto; Parenti, Paolo; Migliorati, Sonia; Di Brisco, Agnese Maria; Vighi, Marco

    2017-11-01

    Biomarkers are widely used in ecotoxicology as indicators of exposure to toxicants. However, their ability to provide ecologically relevant information remains controversial. One of the major problems is understanding whether the measured responses are determined by stress factors or lie within the natural variability range. In a previous work, the natural variability of enzymatic levels in invertebrates sampled in pristine rivers was proven to be relevant across both space and time. In the present study, the experimental design was improved by considering different life stages of the selected taxa and by measuring more environmental parameters. The experimental design considered sampling sites in 2 different rivers, 8 sampling dates covering the whole seasonal cycle, 4 species from 3 different taxonomic groups (Plecoptera, Perla grandis; Ephemeroptera, Baetis alpinus and Epeorus alpicula; Tricoptera, Hydropsyche pellucidula), different life stages for each species, and 4 enzymes (acetylcholinesterase, glutathione S-transferase, alkaline phosphatase, and catalase). Biomarker levels were related to environmental (physicochemical) parameters to verify any kind of dependence. Data were statistically elaborated using hierarchical multilevel Bayesian models. Natural variability was found to be relevant across both space and time. The results of the present study proved that care should be paid when interpreting biomarker results. Further research is needed to better understand the dependence of the natural variability on environmental parameters. Environ Toxicol Chem 2017;36:3158-3167. © 2017 SETAC. © 2017 SETAC.

  8. Contribution of Spaceflight Environmental Factors to Vision Risks

    Science.gov (United States)

    Zanello, Susana B.

    2011-01-01

    the combined effects of radiation exposure and iron overload on sensitivity to radiation injury in rat eyes. All main eye structures will be analyzed in this study: retina, lens and cornea. A study in collaboration with the Space Human Factors and Habitability Element (SHFH) investigates the effects of lunar dust exposure on the rat cornea. It is anticipated that common underlying oxidative stress mechanisms of damage may be observed as a result of these three stressors: radiation, nutritional iron and lunar dust. The contribution of fluid shift is addressed by a study using rats subjected to hindlimb suspension. The hypothesis to be tested in this study is that the mechanical stress imparted by the pressure differential across the optic disc and lamina cribosa will impact oxygenation (therefore causing oxidative stress and hypoxia) and cell survival. This study also includes the assessment of two nutritional antioxidant countermeasures: epigallocatechin gallate (green tea) and resveratrol. Finally, as a result of two successful tissue sharing efforts, we are proceeding with the analysis of eye samples of mice aboard two shuttle missions: STS-133 and STS-135. Results from the STS-133 study are presented in an independent abstract. Briefly, the results show that spaceflight represents a source of environmental stress that directly translates into oxidative and cellular stress in the retina. Similar analysis is also planned for the cornea. These samples add large value to our current vision research as they provide data on the direct effects of low-earth orbit spaceflight on eye structures and physiology.

  9. Fatores ambientais e endometriose Environmental factors and endometriosis

    Directory of Open Access Journals (Sweden)

    Patrick Bellelis

    2011-08-01

    Full Text Available A endometriose representa uma afecção ginecológica comum, atingindo de 5%-15% das mulheres no período reprodutivo e até 3%-5% na fase pós-menopausa. Essa doença é definida pelo implante de estroma e/ou epitélio glandular endometrial em localização extrauterina, podendo comprometer diversos locais. Humanos e animais são expostos diariamente a poluentes químicos que têm a capacidade de influenciar negativamente processos fisiológicos e, potencialmente, causar doenças, dentre elas a endometriose. Com esta revisão tivemos por objetivo relacionar a influência dos fatores ambientais e dietéticos na gênese da endometriose. O mecanismo pelo qual a dioxina e seus símiles (TCDD/PCBs atuam na alteração da fisiologia endometrial permanence incerta e é especulativa devido à dificuldade em se avaliar a exposição na vida intraútero, infância e vida adulta e suas reais consequências, além das limitações de sua reprodução in vitro. Devemos entender melhor o mecanismo de ação desses poluentes amibentais não só na saúde reprodutiva, mas na saúde em geral do indivíduo, para se promover estratégias de prevenção que devem incluir não só a educação populacional, mas o estabelecimento de limites de exposição, técnicas menos poluentes e melhor aproveitamento dos nossos recursos naturais.Endometriosis represents a common gynecological condition affecting 5%-15% of childbearing age women and up to 3% 5% of post-menopausal women. This disease is defined by the presence of stromal and/or endometrial glandular epithelium implants in extra-uterine locations possibly compromising several sites. Humans and animals are daily exposed to chemical pollutants that could adversely influence physiological processes and potentially cause diseases, including endometriosis. In this review, the authors aimed at settling the influence of environmental and dietary factors on endometriosis pathogenesis. The mechanism by which dioxin and its

  10. Perception of built environmental factors and physical activity among adolescents in Nigeria

    Science.gov (United States)

    2014-01-01

    Background Understanding environmental factors related to adolescents’ physical activity can inform intervention for obesity control and prevention, but virtually no study has been conducted in the African region, where adolescents’ physical inactivity and chronic diseases rates are rising. This study assessed associations between perceived built environmental variables and adolescents’ physical activity (active transportation to school and leisure-time moderate-to- vigorous physical activity), and the moderating effects of neighborhood-level income on association between environmental variables and physical activity among Nigerian boys and girls. Methods Participants were 1006 adolescents (12–19 years, 50.4% girls) randomly selected from 11 secondary schools in Maiduguri city, Nigeria. Physical activity and perceptions of environmental characteristics were assessed by validated self-report questionnaires. Separate gender-based, hierarchical multiple moderated linear regression analyses were used to examine the direct associations between the environmental perceptions and physical activity variables (active transportation and leisure-time MVPA; dependent variables), as well as the moderating effects of neighborhood-level income. Results Only in boys were direct associations and interaction effect of neighborhood-level income found. Access to destinations was positively associated with active transportation to school (β = 0.18; CI = 0.67, 2.24); while residential density (β = 0.10; CI = 0.01, 1.74) and availability/quality of infrastructures (β = 0.14; CI = 0.49, 2.68) were positively associated with leisure-time MVPA. Also, neighborhood-level income moderated the association between perceived safety and leisure-time MVPA, with more perceived safety related to less MVPA (β = -0.16; CI = -0.01, -0.70) in boys living in high SES neighborhood but marginally related to more MVPA (β = 0.11; CI = -0.04, 2.88, p = 0

  11. Exploring factors relevant in the assessment of the return-to-work process of employees on long-term sickness absence due to a depressive disorder: a focus group study

    Directory of Open Access Journals (Sweden)

    Muijzer Anna

    2012-02-01

    Full Text Available Abstract Background Efforts undertaken during the Return-to-Work (RTW process need to be sufficient in order to optimize the quality of the RTW process. The purpose of this study was to explore factors relevant to Return-to-Work Effort Sufficiency (RTW-ES in cases of sick-listed employees with a Depressive Disorder (DD. Method A case of a long-term sick-listed employee with a DD applying for disability benefits was used to gather arguments and grounds relevant to the assessment of RTW-ES. Two focus group meetings were held, consisting of Labor Experts working at the Dutch Social Insurance Institute. Factors were collected and categorized using the International Classification of Functioning, Disability and Health (ICF model. Results Sixteen factors relevant to RTW-ES assessment in a case of DD were found, categorized in the ICF-model under activities (e.g. functional capacity, personal (e.g. competencies, attitude and environmental domain (e.g. employer-employee relationship, or categorized under interventions, job accommodations and measures. Conclusions This study shows that 16 factors are relevant in the assessment of RTW-ES in employees sick-listed due to DD. Further research is necessary to expand this knowledge to other health conditions, and to investigate the impact of these results on the quality of the RTW-ES assessment.

  12. FACTORS OF NANOTECHNOLOGY AND BIODIVERSITY: ENVIRONMENTAL AND EDUCATIONAL ASPECTS

    OpenAIRE

    A. V. Kozachek

    2015-01-01

    The aim is to consider the features of impact of nanotechnology on biodiversity in the future.Methods. We suggest an approach, according to which nanotechnologies are viewed as key technologies of the sixth technological order. It is assumed that nanotechnology may be a potential source of environmental problems of the future, and the basis for the creation of new advanced types of environmental engineering and technology. Since all of the above is important both within the actual environment...

  13. Principle of an operational complexity index for the characterization of the human factor relevance of future reactors concepts

    International Nuclear Information System (INIS)

    Papin, Bernard

    2004-01-01

    With the increasing reliability of the modern technological systems, the human contribution to the global risk in the operation of industrial systems is becoming more and more significant : in the nuclear reactor operation for example, a recent PSA estimation of this contribution is about 25% of the risk of core melting, all situations considered. This urges the designers of future nuclear reactors to consider the minimisation of this Human Factor (HF) contribution, at the very early stage of their design : the experience feedback shows that this is indeed at this stage that the fundamental design options, impacting the most the human reliability in operation, are fixed. The problem is that at these early design stages, it is also quite impossible to apply formal human reliability methods to support this HF optimisation, while the precise operating conditions of the reactor are not yet known in enough details. In this paper, another approach of the HF evaluation during the design, based on the functional and operational complexity assessment, is proposed. As an illustration, this approach is used to compare various concepts of Pressurized Water Reactors from the point of view of the Human Factor relevance. (Author)

  14. Factors relevant to the recycling or reuse of components arising from the decommissioning and refurbishment of nuclear facilities

    International Nuclear Information System (INIS)

    1988-01-01

    The decommissioning and decontamination of nuclear facilities is a topic of great interest to many Member States of the International Atomic Energy Agency (IAEA) because of the large number of older nuclear facilities which are or soon will be retired from service. To assist in the development of the required decommissioning expertise, the IAEA is developing reports and recommendations which will eventually form an integrated information base covering in a systematic way the wide range of topics associated with decommissioning. This information is required so that Member States can decommission their nuclear facilities in a safe, timely and cost effective manner and the IAEA can effectively respond to requests for assistance. One area which warrants more detailed analyses is an assessment of the factors important to the recycling or reuse of components arising from the refurbishment or decommissioning of nuclear plants, the topic of the present report. The document provides an up to date review of the engineering, social, scientific and administrative factors relevant to the safe recycling or reuse of components arising from decommissioning or refurbishment of nuclear facilities. This report should be of interest to owners, operators, policy makers and regulators involved with nuclear facilities, especially those in developing countries. Refs, figs and tabs

  15. Systematic review of environmental risk factors for Obsessive-Compulsive Disorder: A proposed roadmap from association to causation.

    Science.gov (United States)

    Brander, Gustaf; Pérez-Vigil, Ana; Larsson, Henrik; Mataix-Cols, David

    2016-06-01

    To synthesize the current knowledge on possible environmental risk factors for Obsessive-Compulsive Disorder (OCD). We conducted a systematic review following PRISMA guidelines. The Embase, PubMed and Scopus databases were searched up until October 6, 2015, employing relevant keywords and MeSH terms. 128 studies met inclusion criteria. Potential environmental risk factors for OCD have been identified in the broad areas of perinatal complications, reproductive cycle, and stressful life events. There is limited evidence regarding other potential risk factors, such as parental age, season of birth, socioeconomic status, parental rearing practices, infections, traumatic brain injury, substance use or vitamin deficiency. In general, studies were of limited methodological quality. At present, no environmental risk factors have convincingly been associated with OCD. We propose a roadmap for future studies, consisting of longitudinal, population-based research, employing quasi-experimental family and twin designs to identify risk factors that are not only associated with the disorder but also contribute to its causation either directly or moderating the effect of genes. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Industry efficiency and total factor productivity growth under resources and environmental constraint in China.

    Science.gov (United States)

    Tao, Feng; Li, Ling; Xia, X H

    2012-01-01

    The growth of China's industry has been seriously depending on energy and environment. This paper attempts to apply the directional distance function and the Luenberger productivity index to measure the environmental efficiency, environmental total factor productivity, and its components at the level of subindustry in China over the period from 1999 to 2009 while considering energy consumption and emission of pollutants. This paper also empirically examines the determinants of efficiency and productivity change. The major findings are as follows. Firstly, the main sources of environmental inefficiency of China's industry are the inefficiency of gross industrial output value, the excessive energy consumption, and pollutant emissions. Secondly, the highest growth rate of environmental total factor productivity among the three industrial categories is manufacturing, followed by mining, and production and supply of electricity, gas, and water. Thirdly, foreign direct investment, capital-labor ratio, ownership structure, energy consumption structure, and environmental regulation have varying degrees of effects on the environmental efficiency and environmental total factor productivity.

  17. Environmental Factors and Colorectal Tumor Risk in Individuals With Hereditary Nonpolyposis Colorectal Cancer

    NARCIS (Netherlands)

    Diergaarde, B.; Braam, H.; Vasen, H.F.; Nagengast, F.M.; Muijen, van G.N.P.; Kok, F.J.; Kampman, E.

    2007-01-01

    Background & Aims: Individuals with hereditary nonpolyposis colorectal cancer (HNPCC) are at increased risk for colorectal cancer. Environmental factors might play a role in HNPCC-associated carcinogenesis. The aim of this study was to gain insight into the effects of environmental factors on

  18. Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits

    NARCIS (Netherlands)

    Aguirre-Gamboa, Raul; Joosten, Irma; Urbano, Paulo C. M.; van der Molen, Renate G.; van Rijssen, Esther; van Cranenbroek, Bram; Oosting, Marije; Smeekens, Sanne; Jaeger, Martin; Zorro, Maria; Withoff, Sebo; van Herwaarden, Antonius E.; Sweep, Fred C. G. J.; Netea, Romana T.; Swertz, Morris A.; Franke, Lude; Xavier, Ramnik J.; Joosten, Leo A. B.; Netea, Mihai G.; Wijmenga, Cisca; Kumar, Vinod; Li, Yang; Koenen, Hans J. P. M.

    2016-01-01

    Effective immunity requires a complex network of cellular and humoral components that interact with each other and are influenced by different environmental and host factors. We used a systems biology approach to comprehensively assess the impact of environmental and genetic factors on immune cell

  19. Response of benthic fauna to different pollutants: Some case studies and relevance of benthos to environmental impact assessment

    Digital Repository Service at National Institute of Oceanography (India)

    Ansari, Z.A.; Ingole, B.S.; Furtado, R.

    Franjipane (ed.) Marine pollution and waste disposal. Pergamon Press New york. pp.193-196. Christie, H. 1980. Methods for ecological monitoring: Biological interactions in a rocky sub-tidal community. Helgolande Meeresunters, 33: 367-374. Dauer, D.M. and W... be a direct consequence of the major environmental changes, including dumping of the municipal and industrial wastes. leading to extreme deterioration in the marine environment of the coastal waters of Mumbai (Anon., 1975). Shallow coastal regions...

  20. [Environmental pollutants as adjuvant factors of immune system derived diseases].

    Science.gov (United States)

    Lehmann, Irina

    2017-06-01

    The main task of the immune system is to protect the body against invading pathogens. To be able to do so, immune cells must be able to recognize and combat exogenous challenges and at the same time tolerate body-borne structures. A complex regulatory network controls the sensitive balance between defense and tolerance. Perturbation of this network ultimately leads to the development of chronic inflammation, such as allergies, autoimmune reactions, and infections, because the immune system is no longer able to efficiently eliminate invading pathogens. Environmental pollutants can cause such perturbations by affecting the function of immune cells in such a way that they would react hypersensitively against allergens and the body's own structures, respectively, or that they would be no longer able to adequately combat pathogens. This indirect effect is also known as adjuvant effect. For pesticides, heavy metals, wood preservatives, or volatile organic compounds such adjuvant effects are well known. Examples of the mechanism by which environmental toxins contribute to chronic inflammatory diseases are manifold and will be discussed along asthma and allergies.While the immune system of healthy adults is typically well able to distinguish between foreign and endogenous substances even under adverse environmental conditions, that of children would react much more sensible upon comparable environmental challenges. To prevent priming for diseases by environmental cues during that highly sensitive period of early childhood children are to be particularly protected.

  1. [Editorial] Environmental and occupational risk factors associated with different pathological conditions.

    Science.gov (United States)

    Signorelli, Salvatore Santo; Ferrante, Margherita

    2017-05-01

    A wide body of evidence indicates that environmental and occupational risk factors are associated with the development of pathological disorders. The pathogenic role of many environmental pollutants or occupational contaminants is already known and has been extensively investigated. However, the molecular mechanisms of action and the pathogenic effects of many substances remain unknown. Therefore, there is a need to better investigate the role of new environmental and occupational risk factors that may cause the development of several diseases.

  2. Applicable or relevant and appropriate requirements (ARARs) for remedial actions at the Paducah Gaseous Diffusion Plant: A compendium of environmental laws and guidance

    International Nuclear Information System (INIS)

    Etnier, E.L.; Eaton, L.A.

    1992-03-01

    Section 121 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980 specifies that remedial actions for cleanup of hazardous substances found at sites placed on the National Priorities List (NPL) by the US Environmental Protection Agency (EPA) must comply with applicable or relevant and appropriate requirements (ARARs) or standards under federal and state environmental laws. To date, the US Department of Energy (DOE) Paducah Gaseous Diffusion Plant (PGDP) has not been on the NPL. Although DOE and EPA have entered into an Administrative Consent Order (ACO), the prime regulatory authority for cleanup at PGDP will be the Resource Conservation and Recovery Act (RCRA). This report supplies a preliminary list of available federal and state ARARs that might be considered for remedial response at PGDP in the event that the plant becomes included on the NPL or the ACO is modified to include CERCLA cleanup. A description of the terms ''applicable'' and ''relevant and appropriate'' is provided, as well as definitions of chemical-, location-, and action-specific ARARS. ARARs promulgated by the federal government and by the state of Kentucky are listed in tables. In addition, the major provisions of RCRA, the Safe Drinking Water Act, the Clean Water Act, the Clean Air Act, and other acts, as they apply to hazardous and radioactive waste cleanup, are discussed

  3. Reaction of simple sterile sugar beet hybrids to regulated environmental factors for sugar yield

    Directory of Open Access Journals (Sweden)

    М. О. Корнєєва

    2014-03-01

    Full Text Available Sugar yield, an important indicator, is resulting from interaction of two components: the yield and sugar content, both they are controlled by polygenes, and influenced significantly by environment. A.V. Kilchevskyi and L.V. Hotyliova pointed to the fact that in breeding, contrary to evolution, stabilizing forms are dominated by driving ones, which determine the growth response to regulated factors and decreased resistance to non-regulated environmental factors [1]. A relevant breeding trend is to create the genotypes adequate with certain technologies, so to say «low input variety high input variety» i.e. varieties with low and high energy contribution to technology. From this perspective, selection of stable in their manifestation lines against the analyzing backgrounds has become an important element of the breeding process [2]. Home scientists, such as A.L. Mazmulov and M.S. Hrytsyk have contributed greatly to the development and application of the agro-backgrounds [3, 4].

  4. Environmental factors associated with a spectrum of neurodevelopmental deficits.

    Science.gov (United States)

    Mendola, Pauline; Selevan, Sherry G; Gutter, Suzanne; Rice, Deborah

    2002-01-01

    A number of environmental agents have been shown to demonstrate neurotoxic effects either in human or laboratory animal studies. Critical windows of vulnerability to the effects of these agents occur both pre- and postnatally. The nervous system is relatively unique in that different parts are responsible for different functional domains, and these develop at different times (e.g., motor control, sensory, intelligence and attention). In addition, the many cell types in the brain have different windows of vulnerability with varying sensitivities to environmental agents. This review focuses on two environmental agents, lead and methylmercury, to illustrate the neurobehavioral and cognitive effects that can result from early life exposures. Special attention is paid to distinguishing between the effects detected following episodes of poisoning and those detected following lower dose exposures. Perinatal and childhood exposure to high doses of lead results in encephalopathy and convulsions. Lower-dose lead exposures have been associated with impairment in intellectual function and attention. At high levels of prenatal exposure, methylmercury produces mental retardation, cerebral palsy and visual and auditory deficits in children of exposed mothers. At lower levels of methylmercury exposure, the effects in children have been more subtle. Other environmental neurotoxicants that have been shown to produce developmental neurotoxicity include polychlorinated biphenyls (PCBs), dioxins, pesticides, ionizing radiation, environmental tobacco smoke, and maternal use of alcohol, tobacco, marijuana and cocaine. Exposure to environmental agents with neurotoxic effects can result in a spectrum of adverse outcomes from severe mental retardation and disability to more subtle changes in function depending on the timing and dose of the chemical agent. Copyright 2002 Wiley-Liss, Inc.

  5. System-wide impacts of environmental cost factors

    International Nuclear Information System (INIS)

    Rogers, M.; Kennedy, T.; Finnell, J.; Hoelscher, J.

    1992-01-01

    This paper presents a continuum of approaches to considering environmental externalities in the utility resource selection process. While photovoltaic (PV) technologies can play a role in reducing emissions, they are generally not cost-competitive with conventional technologies, even when cost estimates for environmental damages are introduced. Several approaches are explored to determine whether PV becomes more competitive when emission reduction strategies are considered on a regional basis. Finally, preliminary analysis was performed with the Midas utility planning model to develop emission credits based on PV's ability to displace emissions on a net system basis

  6. Identifying factors relevant in the assessment of return-to-work efforts in employees on long-term sickness absence due to chronic low back pain: a focus group study

    Directory of Open Access Journals (Sweden)

    Muijzer Anna

    2012-01-01

    Full Text Available Abstract Background Efforts undertaken during the return to work (RTW process need to be sufficient to prevent unnecessary applications for disability benefits. The purpose of this study was to identify factors relevant to RTW Effort Sufficiency (RTW-ES in cases of sick-listed employees with chronic low back pain (CLBP. Methods Using focus groups consisting of Labor Experts (LE's working at the Dutch Social Insurance Institute, arguments and underlying grounds relevant to the assessment of RTW-ES were investigated. Factors were collected and categorized using the International Classification of Functioning, Disability and Health (ICF model. Results Two focus groups yielded 19 factors, of which 12 are categorized in the ICF model under activities (e.g. functional capacity and in the personal (e.g. age, tenure and environmental domain (e.g. employer-employee relationship. The remaining 7 factors are categorized under intervention, job accommodation and measures. Conclusions This focus group study shows that 19 factors may be relevant to RTW-ES in sick-listed employees with CLBP. Providing these results to professionals assessing RTW-ES might contribute to a more transparent and systematic approach. Considering the importance of the quality of the RTW process, optimizing the RTW-ES assessment is essential.

  7. The fish sexual development test: an OECD test guideline proposal with possible relevance for environmental risk assessment. Results from the validation programme

    DEFF Research Database (Denmark)

    Holbech, Henrik; Brande-Lavridsen, Nanna; Kinnberg, Karin Lund

    2010-01-01

    The Fish Sexual Development Test (FSDT) has gone through two validations as an OECD test guideline for the detection of endocrine active chemicals with different modes of action. The validation has been finalized on four species: Zebrafish (Danio rerio), Japanese medaka (Oryzias latipes), three s...... as a population relevant endpoint and the results of the two validation rounds will be discussed in relation to environmental risk assessment and species selection....... for histology. For all three methods, the fish parts were numbered and histology could therefore be linked to the vitellogenin concentration in individual fish. The two core endocrine relevant endpoints were vitellogenin concentrations and phenotypic sex ratio. Change in the sex ratio is presented...

  8. Environmental Linguistics: A Typology of Visual Factors in Shopping Malls.

    Science.gov (United States)

    Woods, John D.; Sewell, Edward H., Jr.

    Environment may be regarded as a form of communication, with environmental linguistics becoming a new discipline that will have to be explored. Its goal is to demystify some of the constructs that contribute to the built environment as a communication tool. Treating the built environment as a language requires a recognition of its dynamic nature.…

  9. Effectiveness and relevant factors of platelet-rich plasma treatment in managing plantar fasciitis:A systematic review

    Directory of Open Access Journals (Sweden)

    Seet Khing Chiew

    2016-01-01

    Full Text Available Background: Plantar fasciitis (PF is a common foot complaint, affects both active sportsmen and physically inactive middle age group. It is believed that PF results from degenerative changes rather than inflammation. Platelet-rich plasma (PRP therapy has been introduced as an alternative therapy for PF. This study is aimed to systematically review to the effectiveness and relevant factors of PRP treatment in managing PF. Materials and Methods: A search was conducted in electronic databases, including PubMed, Scopus, and Google Scholar using different keywords. Publications in English-language from 2010 to 2015 were included. Two reviewers extracted data from selected articles after the quality assessment was done. Results: A total of 1126 articles were retrieved, but only 12 articles met inclusion and exclusion criteria. With a total of 455 patients, a number of potentially influencing factors on the effectiveness of PRP for PF was identified. In all these studies, PRP had been injected directly into the plantar fascia, with or without ultrasound guidance. Steps from preparation to injection were found equally crucial. Amount of collected blood, types of blood anti-coagulant, methods in preparing PRP, speed, and numbers of time the blood samples were centrifuged, activating agent added to the PRP and techniques of injection, were varied between different studies. Regardless of these variations, superiority of PRP treatment compared to steroid was reported in all studies. Conclusion: In conclusion, PRP therapy might provide an effective alternative to conservative management of PF with no obvious side effect or complication. The onset of action after PRP injection also greatly depended on the degree of degeneration.

  10. Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes?

    Directory of Open Access Journals (Sweden)

    Ashley M Miller

    Full Text Available Preliminary data mostly from animal models suggest the sST2/IL-33 pathway may have causal relevance for vascular disease and diabetes and thus point to a potential novel inflammatory link to cardiometabolic disease. However, the characterisation of sST2 levels in terms of metabolic or vascular risk in man is completely lacking. We sought to address this gap via a comprehensive analysis of risk factor and vascular correlates of sST2 in a cross-sectional study (pSoBid. We measured sST2 in plasma in 639 subjects and comprehensively related it to cardiovascular and diabetes risk factors and imaged atherosclerosis measures. Circulating sST2 levels increased with age, were lower in women and in highest earners. After adjusting for age and gender, sST2 levels associated strongly with markers of diabetes, including triglycerides [effect estimate (EE per 1 standard deviation increase in sST2:1.05 [95%CI 1.01,1.10], liver function (alanine aminotransaminase [ALT] and γ-glutamyl transferase [GGT]: EE 1.05 [1.01,1.09] and 1.13 [1.07,1.19] respectively, glucose (1.02 [1.00,1.03] and sICAM-1 (1.05 [1.02,1.07]. However, sST2 levels were not related to smoking, cholesterol, blood pressure, or atheroma (carotid intima media thickness, plaque presence. These results suggest that sST2 levels, in individuals largely without vascular disease, are related principally to markers associated with diabetes and ectopic fat and add support for a role of sST2 in diabetes. Further mechanistic studies determining how sST2 is linked to diabetes pathways may offer new insights into the inflammatory paradigm for type 2 diabetes.

  11. Research on the nutrition and cognition of high-risk stroke groups in community and the relevant factors.

    Science.gov (United States)

    Zhao, N-N; Zeng, K-X; Wang, Y-L; Sheng, P-J; Tang, C-Z; Xiao, P; Liu, X-W

    2017-12-01

    To investigate the prevalence rate of nutritional risk in high-risk stroke groups in community, analyze its influencing factors, and analyze and compare the relationship between nutritional risk or malnutrition assessed by different nutritional evaluation methods and cognitive function, so as to provide the basis and guidance for clinical nutritional assessment and support. A cross-sectional survey was performed for 1196 cases in high-risk stroke groups in community from December 2015 to January 2017. At the same time, the nutritional status of patients was evaluated using the mini nutritional assessment (MNA) and MNA-short form (MNA-SF), and the cognitive status of patients was evaluated using the mini-mental state examination (MMSE). Moreover, the relevant influencing factors of nutritional risk and MMSE score were analyzed and compared. High-risk stroke groups in community suffered from a high risk of malnutrition. MNA-SF had a higher specificity and lower false positive rate than MNA. Nutritional risk occurred more easily in high-risk stroke groups in community with a history of diabetes mellitus, less physical exercise or light manual labor, daily use of multiple drugs, and higher age. Those with a higher nutritional risk were more prone to cognitive impairment. High-risk stroke groups in community, complicated with hyperhomocysteinemia, daily use of three or more kinds of prescription drugs, and a previous history of stroke, were accompanied by cognitive impairment easily. MNA-SF can be used for the nutritional screening of high-risk stroke groups in community. For the high-risk stroke groups in community, the rational nutritional diet should be publicized, blood sugar should be controlled in a scientific manner and physical exercise should be moderately increased.

  12. Estimated pKa values for the environmentally relevant C1 through C8 perfluorinated sulfonic acid isomers.

    Science.gov (United States)

    Rayne, Sierra; Forest, Kaya

    2016-10-14

    In order to estimate isomer-specific acidity constants (pKa) for the perfluorinated sulfonic acid (PFSA) environmental contaminants, the parameterization method 6 (PM6) pKa prediction method was extensively validated against a wide range of carbon oxyacids and related sulfonic/sulfinic acids. Excellent pKa prediction performance was observed for the carbon oxyacids using the PM6 method, but this approach was found to have a severe positive bias for sulfonic/sulfinic acids. To overcome this obstacle, a correlation was developed between non-adjusted PM6 pKa values and the corresponding experimentally obtained/estimated acidity constants for a range of representative alkyl, aryl and halogen-substituted sulfonic acids. Application of this correction to the PM6 values allows for extension of this computational method to a new acid functional group. When used to estimate isomer-specific pKa values for the C1 through C8 PFSAs, the modified PM6 approach suggests an adjusted pKa range from -5.3 to -9.0, indicating that all members of this class of well-known environmental contaminants will be effectively completely dissociated in aquatic systems.

  13. The relevance of large scale environmental research infrastructures from the point of view of Ethics: the case of EMSO

    Science.gov (United States)

    Favali, Paolo; Beranzoli, Laura; Best, Mairi; Franceschini, PierLuigi; Materia, Paola; Peppoloni, Silvia; Picard, John

    2014-05-01

    EMSO (European Multidisciplinary Seafloor and Water Column Observatory) is a large-scale European Research Infrastructure (RI). It is a geographically distributed infrastructure composed of several deep-seafloor and water-column observatories, which will be deployed at key sites in European waters, spanning from the Arctic, through the Atlantic and Mediterranean, to the Black Sea, with the basic scientific objective of real-time, long-term monitoring of environmental processes related to the interaction between the geosphere, biosphere and hydrosphere. EMSO is one of the environmental RIs on the ESFRI roadmap. The ESRFI Roadmap identifies new RIs of pan-European importance that correspond to the long term needs of European research communities. EMSO will be the sub-sea segment of the EU's large-scale Earth Observation program, Copernicus (previously known as GMES - Global Monitoring for Environment and Security) and will significantly enhance the observational capabilities of European member states. An open data policy compliant with the recommendations being developed within the GEOSS initiative (Global Earth Observation System of Systems) will allow for shared use of the infrastructure and the exchange of scientific information and knowledge. The processes that occur in the oceans have a direct impact on human societies, therefore it is crucial to improve our understanding of how they operate and interact. To encompass the breadth of these major processes, sustained and integrated observations are required that appreciate the interconnectedness of atmospheric, surface ocean, biological pump, deep-sea, and solid-Earth dynamics and that can address: • natural and anthropogenic change; • interactions between ecosystem services, biodiversity, biogeochemistry, physics, and climate; • impacts of exploration and extraction of energy, minerals, and living resources; • geo-hazard early warning capability for earthquakes, tsunamis, gas-hydrate release, and slope

  14. Description of relevant scenarios in the field of agricultural, environmental and climate policy and energy prices for the preliminary study on a Roadmap for the 'SuikerUnie'

    International Nuclear Information System (INIS)

    Plomp, A.J.

    2011-11-01

    In the Dutch Long Term Agreements on energy efficiency (MJA3 and MEE)the Dutch government and industry agreed to strive for a 30% energy efficiency improvement in 2020 compared to 2005. To reach more than 30%, it is not enough to optimize; instead larger process changes will be needed. An important instrument is the realization of preliminary studies and roadmaps, which are supported by the government. This memo offers an overview of relevant developments and scenarios from Agricultural, climate and environmental policy and energy prices for the Dutch sugar industry. This memo serves as input for the Preliminary study Roadmap SuikerUnie. [nl

  15. On the indiscriminate use of imported emission factors in environmental impact assessment: A case study in Chile

    International Nuclear Information System (INIS)

    Bernal, María Fernanda; Oyarzún, Jorge; Oyarzún, Ricardo

    2017-01-01

    Environmental Impact Assessment (EIA) aims to determine if the environmental effect of an activity or project complies with standards and regulations. A primary component of the environment to evaluate is air and the effect that various activities can have on its quality. To this end, emission factors (EFs), which are empirical coefficients or mathematical relationships, are normally used. The present research critically analyzes the implications and consequences of using imported EFs in environmental impact studies (EISs), taking as case of study the situation in Chile. Among the main results, the widespread use of EFs in EISs in the country and the lack of assessments of their actual applicability stand out. In addition, the official guidelines related to emissions estimation that are used for EIA in the country mostly include EFs derived elsewhere, without considering the recommendations or restrictions that the original sources indicate for their use. Finally, the broad use of default values defined for the Metropolitan Region in Central Chile, is highly questionable for a country that extends north-south along more than 35° of latitude, with wide variability in climate, traffic conditions, population, soil types, etc. Finally, it is very likely that situations similar to those observed in the present work occurs in other countries with young environmental impact assessment systems, and therefore, that the results herein presented should be of general interest and relevance. - Highlights: • Emission factors are widely used in environmental impact assessment in Chile. • There is a lack of a proper understanding of the limitations of EFs for EIA. • Imported emission factors use requires caution and full understanding. • Misuse of foreign EFs may have serious environmental and economic consequences.

  16. On the indiscriminate use of imported emission factors in environmental impact assessment: A case study in Chile

    Energy Technology Data Exchange (ETDEWEB)

    Bernal, María Fernanda [Civil and Environmental Engineering, Universidad de La Serena (Chile); Oyarzún, Jorge [Department of Mining Engineering, Universidad de La Serena (Chile); Oyarzún, Ricardo, E-mail: royarzun@userena.cl [Department of Mining Engineering, Universidad de La Serena (Chile); Centro de Estudios Avanzados en Zonas Aridas, La Serena (Chile)

    2017-05-15

    Environmental Impact Assessment (EIA) aims to determine if the environmental effect of an activity or project complies with standards and regulations. A primary component of the environment to evaluate is air and the effect that various activities can have on its quality. To this end, emission factors (EFs), which are empirical coefficients or mathematical relationships, are normally used. The present research critically analyzes the implications and consequences of using imported EFs in environmental impact studies (EISs), taking as case of study the situation in Chile. Among the main results, the widespread use of EFs in EISs in the country and the lack of assessments of their actual applicability stand out. In addition, the official guidelines related to emissions estimation that are used for EIA in the country mostly include EFs derived elsewhere, without considering the recommendations or restrictions that the original sources indicate for their use. Finally, the broad use of default values defined for the Metropolitan Region in Central Chile, is highly questionable for a country that extends north-south along more than 35° of latitude, with wide variability in climate, traffic conditions, population, soil types, etc. Finally, it is very likely that situations similar to those observed in the present work occurs in other countries with young environmental impact assessment systems, and therefore, that the results herein presented should be of general interest and relevance. - Highlights: • Emission factors are widely used in environmental impact assessment in Chile. • There is a lack of a proper understanding of the limitations of EFs for EIA. • Imported emission factors use requires caution and full understanding. • Misuse of foreign EFs may have serious environmental and economic consequences.

  17. The Sustainable Office. An exploration of the potential for factor 20 environmental improvement of office accommodation

    OpenAIRE

    Van den Dobbelsteen, A.A.J.F.

    2004-01-01

    Sustainable development is the goal of a balance between economy and the environment, whilst establishing a better spread prosperity across the world. In order to make this possible, the environmental load of our commodities needs to be reduced by a factor of 20. This factor 20 can also be translated to the office market. The PhD research presented in this thesis focussed on finding solutions effectively contributing to factor 20 environmental improvement of office accommodation. In order to ...

  18. Environmental Factors of Distance Learning: An Exploratory Study

    Science.gov (United States)

    Klaus, Tim; Changchit, Chuleeporn

    2014-01-01

    The widespread use of the Internet has opened new avenues for learning in higher education. Distance education through the Internet has had a large increase over the last decade. This study focuses on examining factors of the online course environment that affect student satisfaction. The results identify factors that affect students' satisfaction…

  19. Applicable or Relevant and Appropriate Requirements (ARARs) for Remedial Action at the Oak Ridge Reservation: A compendium of major environmental laws

    International Nuclear Information System (INIS)

    Etnier, E.L.; McDonald, E.P.; Houlberg, L.M.

    1993-07-01

    Section 121 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980 specifies that remedial actions for cleanup of hazardous substances must comply with applicable or relevant and appropriate requirements (ARARS) or standards under federal and state environmental laws. The US Department of Energy (DOE) Oak Ridge Reservation (ORR) was placed on the National Priorities List by the US Environmental Protection Agency (EPA) on November 21, 1989, effective December 21, 1989. As a result of this listing, DOE, EPA, and the Tennessee Department of Environment and Conservation have signed a Federal Facility Agreement (FFA) for the environmental restoration of the ORR. Section XXI(F) of the FFA calls for the preparation of a draft listing of all ARARs as mandated by CERCLA section 121. This report supplies a preliminary list of available federal and state ARARs that might be considered for remedial response at the ORR. A description of the terms ''applicable'' and ''relevant and appropriate'' is provided, as well as definitions of chemical-, location-, and action-specific ARARS. ARARs promulgated by the federal government and by the state of Tennessee are listed in tables. In addition, the major provisions of the Resource Conservation and Recovery Act, the Safe Drinking Water Act, the Clean Water Act, the Clean Air and other acts, as they apply to hazardous waste cleanup, are discussed. In the absence of ARARS, CERCLA section 121 provides for the use of nonpromulgated federal criteria, guidelines, and advisories in evaluating the human risk associated with remedial action alternatives. Such nonpromulgated standards are classified as ''to-be-considered'' (TBC) guidance. A ion of available guidance is given; summary tables fist the available federal standards and guidance information. In addition, the substantive contents of the DOE orders as they apply to remediation of radioactively contaminated sites are discussed as TBC guidance

  20. Environmental exposures as a risk factor for fibrolamellar carcinoma.

    Science.gov (United States)

    Graham, Rondell P; Craig, John R; Jin, Long; Oliveira, Andre M; Bergquist, John R; Truty, Mark J; Mounajjed, Taofic; Greipp, Patricia T; Torbenson, Michael S

    2017-06-01

    Fibrolamellar carcinoma was first described in 1956. Subsequent large studies failed to identify cases before 1939 (the start of the World War II). This finding, combined with the presence of aryl hydrocarbon receptors on the tumor cells, have suggested that fibrolamellar carcinomas may be caused by environmental exposures that are new since World War II. To investigate this possibility, the surgical pathology files before 1939 were reviewed for hepatocellular carcinomas resected in young individuals. Two cases of fibrolamellar carcinoma were identified, from 1915 to 1924. The diagnosis of fibrolamellar carcinoma was confirmed at the histologic, ultrastructural and proteomic levels. These two fibrolamellar carcinoma cases clarify a key aspect of fibrolamellar carcinoma biology, reducing the likelihood that these tumors result exclusively from post World War II environmental exposures.

  1. Environmental and Physiological Factors Affect Football Head Impact Biomechanics.

    Science.gov (United States)

    Mihalik, Jason P; Sumrall, Adam Z; Yeargin, Susan W; Guskiewicz, Kevin M; King, Kevin B; Trulock, Scott C; Shields, Edgar W

    2017-10-01

    Recent anecdotal trends suggest a disproportionate number of head injuries in collegiate football players occur during preseason football camp. In warmer climates, this season also represents the highest risk for heat-related illness among collegiate football players. Because concussion and heat illnesses share many common symptoms, we need 1) to understand if environmental conditions, body temperature, and hydration status affect head impact biomechanics; and 2) to determine if an in-helmet thermistor could provide a valid measure of gastrointestinal temperature. A prospective cohort of 18 Division I college football players (age, 21.1 ± 1.4 yr; height, 187.7 ± 6.6 cm; mass, 114.5 ± 23.4 kg). Data were collected during one control and three experimental sessions. During each session, the Head Impact Telemetry System recorded head impact biomechanics (linear acceleration, rotational acceleration, and severity profile) and in-helmet temperature. A wet bulb globe device recorded environmental conditions, and CorTemp™ Ingestible Core Body Temperature Sensors recorded gastrointestinal temperature. Our findings suggest that linear acceleration (P = 0.57), rotational acceleration (P = 0.16), and Head Impact Technology severity profile (P = 0.33) are not influenced by environmental or physiological conditions. We did not find any single or combination of predictors for impact severity. Rotational acceleration was approaching significance between our early experimental sessions when compared with our control session. More research should be conducted to better understand if rotational accelerations are a component of impact magnitudes that are affected due to changes in environmental conditions, body temperature, and hydration status.

  2. Investigation of critical inter-related factors affecting the efficacy of pulsed light for inactivating clinically relevant bacterial pathogens.

    Science.gov (United States)

    Farrell, H P; Garvey, M; Cormican, M; Laffey, J G; Rowan, N J

    2010-05-01

    To investigate critical electrical and biological factors governing the efficacy of pulsed light (PL) for the in vitro inactivation of bacteria isolated from the clinical environment. Development of this alternative PL decontamination approach is timely, as the incidence of health care-related infections remains unacceptably high. Predetermined cell numbers of clinically relevant Gram-positive and Gram-negative bacteria were inoculated separately on agar plates and were flashed with lamp discharge energy (range 3.2-20 J per pulse), the amount of pulsing applied (range 0-60 pulses) and the distance between light source and treatment surface (range 8-20 cm) used. Greater decontamination levels were achieved using a combination of higher lamp discharge energies, increased number of pulses and shorter distances between treatment surface and the xenon light source. Levels of microbial sensitivity also varied depending on the population type, size and age of cultures treated. Production of pigment pyocynanin and alginate slime in mucoid strains of Pseudomonas aeruginosa afforded some protection against lethal action of PL; however, this was evident only by using a combination of reduced amount of pulsing at the lower lamp discharge energies tested. A clear pattern was observed where Gram-positive bacterial pathogens were more resistant to cidal effects of PL compared to Gram negatives. While negligible photoreactivation of PL-treated bacterial strains occurred after full pulsing regimes at the different lamp discharge energies tested, some repair was evident when using a combination of reduced pulsing at the lower lamp discharge energies. Strains harbouring genes for multiple resistances to antibiotics were not significantly more resistant to PL treatments. Slight temperature rises (lamp discharge energies. Presence of organic matter on treatment surface did not significantly affect PL decontamination efficacy, nor did growth of PL-treated bacteria on selective agar

  3. Annotated bibliography of environmentally relevant investigations of uranium mining and milling in the Grants Mineral Belt, northwestern New Mexico

    Science.gov (United States)

    Otton, James K.

    2011-01-01

    Studies of the natural environment in the Grants Mineral Belt in northwestern New Mexico have been conducted since the 1930s; however, few such investigations predate uranium mining and milling operations, which began in the early 1950s. This report provides an annotated bibliography of reports that describe the hydrology and geochemistry of groundwaters and surface waters and the geochemistry of soils and sediments in the Grants Mineral Belt and contiguous areas. The reports referenced and discussed provide a large volume of information about the environmental conditions in the area after mining started. Data presented in many of these studies, if evaluated carefully, may provide much basic information about the baseline conditions that existed over large parts of the Grants Mineral Belt prior to mining. Other data may provide information that can direct new work in efforts to discriminate between baseline conditions and the effects of the mining and milling on the natural environment.

  4. The interaction of actinide and lanthanide ions with hemoglobin and its relevance to human and environmental toxicology

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Amit, E-mail: amitk@barc.gov.in [Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Ali, Manjoor [Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Ningthoujam, Raghumani S. [Chemistry Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Gaikwad, Pallavi [Department of Zoology, Savitribai Phule Pune University, Pune 411 007, Mumbai (India); Kumar, Mukesh [Solid State, Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Nath, Bimalendu B. [Department of Zoology, Savitribai Phule Pune University, Pune 411 007, Mumbai (India); Pandey, Badri N. [Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India)

    2016-04-15

    Highlights: • The sites of Ln and An interaction in Hb depend upon their charge-to-ionic-radii ratio. • Th(IV), Ce(IV) and U(VI) altered structure and oxygen-binding of Hb. • Spectroscopic studies determined binding characteristics of actinides. • Metal–Hb interaction was tested in an environmentally-important aquatic midge, Chironomus. - Abstract: Due to increasing use of lanthanides/actinides in nuclear and civil applications, understanding the impact of these metal ions on human health and environment is a growing concern. Hemoglobin (Hb), which occurs in all the kingdom of living organism, is the most abundant protein in human blood. In present study, effect of lanthanides and actinides [thorium: Th(IV), uranium: U(VI), lanthanum: La(III), cerium: Ce(III) and (IV)] on the structure and function of Hb has been investigated. Results showed that these metal ions, except Ce(IV) interacted with carbonyl and amide groups of Hb, which resulted in the loss of its alpha-helix conformation. However, beyond 75 μM, these ions affected heme moiety. Metal–heme interaction was found to affect oxygen-binding of Hb, which seems to be governed by their closeness with the charge-to-ionic-radius ratio of iron(III). Consistently, Ce(IV) being closest to iron(III), exhibited a greater effect on heme. Binding constant and binding stoichiometry of Th(IV) were higher than that of U(VI). Experiments using aquatic midge Chironomus (possessing human homologous Hb) and human blood, further validated metal–Hb interaction and associated toxicity. Thus, present study provides a biochemical basis to understand the actinide/lanthanide-induced interference in heme, which may have significant implications for the medical and environmental management of lanthanides/actinides toxicity.

  5. The interaction of actinide and lanthanide ions with hemoglobin and its relevance to human and environmental toxicology

    International Nuclear Information System (INIS)

    Kumar, Amit; Ali, Manjoor; Ningthoujam, Raghumani S.; Gaikwad, Pallavi; Kumar, Mukesh; Nath, Bimalendu B.; Pandey, Badri N.

    2016-01-01

    Highlights: • The sites of Ln and An interaction in Hb depend upon their charge-to-ionic-radii ratio. • Th(IV), Ce(IV) and U(VI) altered structure and oxygen-binding of Hb. • Spectroscopic studies determined binding characteristics of actinides. • Metal–Hb interaction was tested in an environmentally-important aquatic midge, Chironomus. - Abstract: Due to increasing use of lanthanides/actinides in nuclear and civil applications, understanding the impact of these metal ions on human health and environment is a growing concern. Hemoglobin (Hb), which occurs in all the kingdom of living organism, is the most abundant protein in human blood. In present study, effect of lanthanides and actinides [thorium: Th(IV), uranium: U(VI), lanthanum: La(III), cerium: Ce(III) and (IV)] on the structure and function of Hb has been investigated. Results showed that these metal ions, except Ce(IV) interacted with carbonyl and amide groups of Hb, which resulted in the loss of its alpha-helix conformation. However, beyond 75 μM, these ions affected heme moiety. Metal–heme interaction was found to affect oxygen-binding of Hb, which seems to be governed by their closeness with the charge-to-ionic-radius ratio of iron(III). Consistently, Ce(IV) being closest to iron(III), exhibited a greater effect on heme. Binding constant and binding stoichiometry of Th(IV) were higher than that of U(VI). Experiments using aquatic midge Chironomus (possessing human homologous Hb) and human blood, further validated metal–Hb interaction and associated toxicity. Thus, present study provides a biochemical basis to understand the actinide/lanthanide-induced interference in heme, which may have significant implications for the medical and environmental management of lanthanides/actinides toxicity.

  6. Common Genetic and Nonshared Environmental Factors Contribute to the Association between Socioemotional Dispositions and the Externalizing Factor in Children

    Science.gov (United States)

    Taylor, Jeanette; Allan, Nicholas; Mikolajewski, Amy J.; Hart, Sara A.

    2013-01-01

    Background: Childhood behavioral disorders including conduct disorder (CD), oppositional defiant disorder (ODD), and attention-deficit/hyperactivity disorder (ADHD) often co-occur. Prior twin research shows that common sets of genetic and environmental factors are associated with these various disorders and they form a latent factor called…

  7. Causal inference between bioavailability of heavy metals and environmental factors in a large-scale region

    International Nuclear Information System (INIS)

    Liu, Yuqiong; Du, Qingyun; Wang, Qi; Yu, Huanyun; Liu, Jianfeng; Tian, Yu; Chang, Chunying; Lei, Jing

    2017-01-01

    The causation between bioavailability of heavy metals and environmental factors are generally obtained from field experiments at local scales at present, and lack sufficient evidence from large scales. However, inferring causation between bioavailability of heavy metals and environmental factors across large-scale regions is challenging. Because the conventional correlation-based approaches used for causation assessments across large-scale regions, at the expense of actual causation, can result in spurious insights. In this study, a general approach framework, Intervention calculus when the directed acyclic graph (DAG) is absent (IDA) combined with the backdoor criterion (BC), was introduced to identify causation between the bioavailability of heavy metals and the potential environmental factors across large-scale regions. We take the Pearl River Delta (PRD) in China as a case study. The causal structures and effects were identified based on the concentrations of heavy metals (Zn, As, Cu, Hg, Pb, Cr, Ni and Cd) in soil (0–20 cm depth) and vegetable (lettuce) and 40 environmental factors (soil properties, extractable heavy metals and weathering indices) in 94 samples across the PRD. Results show that the bioavailability of heavy metals (Cd, Zn, Cr, Ni and As) was causally influenced by soil properties and soil weathering factors, whereas no causal factor impacted the bioavailability of Cu, Hg and Pb. No latent factor was found between the bioavailability of heavy metals and environmental factors. The causation between the bioavailability of heavy metals and environmental factors at field experiments is consistent with that on a large scale. The IDA combined with the BC provides a powerful tool to identify causation between the bioavailability of heavy metals and environmental factors across large-scale regions. Causal inference in a large system with the dynamic changes has great implications for system-based risk management. - Causation between the

  8. Multivariate-Analysis of Phytoplankton and Related Environmental-Factors, in a Shallow Hypertrophic Lake

    NARCIS (Netherlands)

    Romo, S.; Van Tongeren, O.F.R.

    1995-01-01

    Data on some relevant environmental variables and phytoplankton species composition, collected from the hypertrophic shallow lake Albufera of Valencia (Spain) during 1980-88, were examined using Redundancy Analysis (RDA). The hydrological cycle of the lake is manipulated for rice cultivation in the

  9. Genetic, Maternal, and Environmental Risk Factors for Cryptorchidism

    DEFF Research Database (Denmark)

    Barthold, Julia Spencer; Reinhardt, Susanne; Thorup, Jorgen

    2016-01-01

    genetic risk, multiple susceptibility loci, and a role for the maternal environment. Epidemiologic studies have identified low birth weight or intrauterine growth retardation as factors most strongly associated with cryptorchidism, with additional evidence suggesting that maternal smoking and gestational...

  10. Environmental exogenous factors and facial dermatitis: A case control study

    Directory of Open Access Journals (Sweden)

    Wen-Hui Wang

    2017-03-01

    Conclusions: Contact factors play an important role in facial dermatitis. Aggravation by sunlight exposure, ingestion of spicy food, or alcohol are more reported in facial dermatitis compared with nonfacial dermatitis.

  11. Factors Influencing Environmental Management Practices Among Hotels in Malaysia

    OpenAIRE

    Zaiton Samdin; Kasimu Abdu Bakori; Hamimah Hassan

    2012-01-01

    This paper attempts to investigate the factors that influence hotel managers- attitudes towards sustainable tourism practices (STP) in Kuala Lumpur and the state of Selangor in Malaysia. The study distributes 104 questionnaires to hotels ranging from one star to five-star categories including budget hotels. Out of this figure, 60 copies of the questionnaires were returned and analyzed. The finding revealed that of all the seven factors investigated, only the variables measuring incentives and...

  12. [Advances on the research of the environmental risk factors of children autism].

    Science.gov (United States)

    Huang, D N; Jin, Y T

    2017-12-06

    Autism spectrum disorder is a lifelong neurodevelopmental disorder, characterized by social interaction and communication impairments, accompanied by repetitive behaviors. Little is known about the causes and contributing factors for autism. It is difficult to prevent and cure, and has become a globe public health problem. With the development in the prevalence of autism, the idea how the environmental factors cause the autism, gains all attentions. Summarizing latest epidemiological studies and experimental evidence, this review is focused on the effect of environmental factors, including air pollutant, heavy metal and pesticides, and discussed the relation between environmental risk factors and autism. The results showed that risks of autism in children may increase following in prenatal exposure to air pollutants, heavy metal and pesticides. It is needed to do the research on the mechanism of environmental risk factor and autism for more prevention, treatment and control suggestions.

  13. Gene-Environment Interplay in Internalizing Disorders: Consistent Findings across Six Environmental Risk Factors

    Science.gov (United States)

    Hicks, Brian M.; DiRago, Ana C.; Iacono, William G.; McGue, Matt

    2009-01-01

    Background Newer behavior genetic methods can better elucidate gene-environment (G-E) interplay in the development of internalizing (INT) disorders (i.e., major depression and anxiety disorders). However, no study to date has conducted a comprehensive analysis examining multiple environmental risks with the purpose of delineating how general G-E mechanisms influence the development of INT disorders. Methods The sample consisted of 1315 male and female twin pairs participating in the age 17 assessment of the Minnesota Twin Family Study. Quantitative G-E interplay models were used to examine how genetic and environmental risk for INT disorders changes as a function of environmental context. Multiple measures and informants were employed to construct composite measures of INT disorders and 6 environmental risk factors including: stressful life events, mother-child and father-child relationship problems, antisocial and prosocial peer affiliation, and academic achievement and engagement. Results Significant moderation effects were detected between each environmental risk factor and INT such that in the context of greater environmental adversity, nonshared environmental factors became more important in the etiology of INT symptoms. Conclusion Our results are consistent with the interpretation that environmental stressors have a causative effect on the emergence of INT disorders. The consistency of our results suggests a general mechanism of environmental influence on INT disorders regardless of the specific form of environmental risk. PMID:19594836

  14. Psychological, social, and environmental factors to meeting physical activity recommendations among Japanese adults

    Directory of Open Access Journals (Sweden)

    Harada Kazuhiro

    2009-08-01

    Full Text Available Abstract Background Although the benefits of the recommended level of physical activity on reducing chronic diseases are well-established, most of the Japanese population is not sufficiently active. Thus, examining correlates is an important prerequisite for designing relevant polices and effective programs. The present study investigated psychological, social, and environmental factors associated with meeting physical activity recommendations among Japanese adults. Methods Data were analyzed for 1,932 men and women (43.6 ± 13.0 years, who responded to an Internet-based cross-sectional survey. Self-reported measure of physical activity, psychological (self-efficacy, pros, and cons, social (social support, health professional advice, environmental (home fitness equipment, access to facilities, neighborhood safety, enjoyable scenery, frequently observing others exercising, residential area, and demographic (gender, age, marital status, educational level, household income level, employment status variables were obtained. Based on the current national guidelines for exercise in Japan (23 METs·hour per week, respondents were divided into two categories–recommended and not recommended (insufficient and inactive–according to their estimated weekly physical activity level. An adjusted logistic regression model was utilized. Results When adjusting for all other variables, self-efficacy (men: OR = 2.13; 95% CI: 1.55–2.94, women: OR = 2.72; 95% CI: 1.82–4.08 and possessing home fitness equipment (men: OR = 1.55; 95% CI: 1.14–2.10, women: OR = 1.41; 95% CI: 1.01–1.99 for both genders, social support (OR = 1.44; 95% CI: 1.06–1.97 for men, and enjoyable scenery (OR = 1.60; 95% CI: 1.09–2.36 for women were positively associated with attaining the recommended level of physical activity. In women, cons (OR = 0.47; 95% CI: 0.33–0.67 and living in rural areas (OR = 0.50; 95% CI: 0.25–0.97 were negatively associated with meeting the physical

  15. Psychological, social, and environmental factors to meeting physical activity recommendations among Japanese adults.

    Science.gov (United States)

    Shibata, Ai; Oka, Koichiro; Harada, Kazuhiro; Nakamura, Yoshio; Muraoka, Isao

    2009-08-28

    Although the benefits of the recommended level of physical activity on reducing chronic diseases are well-established, most of the Japanese population is not sufficiently active. Thus, examining correlates is an important prerequisite for designing relevant polices and effective programs. The present study investigated psychological, social, and environmental factors associated with meeting physical activity recommendations among Japanese adults. Data were analyzed for 1,932 men and women (43.6 +/- 13.0 years), who responded to an Internet-based cross-sectional survey. Self-reported measure of physical activity, psychological (self-efficacy, pros, and cons), social (social support, health professional advice), environmental (home fitness equipment, access to facilities, neighborhood safety, enjoyable scenery, frequently observing others exercising, residential area), and demographic (gender, age, marital status, educational level, household income level, employment status) variables were obtained. Based on the current national guidelines for exercise in Japan (23 METs.hour per week), respondents were divided into two categories-recommended and not recommended (insufficient and inactive)-according to their estimated weekly physical activity level. An adjusted logistic regression model was utilized. When adjusting for all other variables, self-efficacy (men: OR = 2.13; 95% CI: 1.55-2.94, women: OR = 2.72; 95% CI: 1.82-4.08) and possessing home fitness equipment (men: OR = 1.55; 95% CI: 1.14-2.10, women: OR = 1.41; 95% CI: 1.01-1.99) for both genders, social support (OR = 1.44; 95% CI: 1.06-1.97) for men, and enjoyable scenery (OR = 1.60; 95% CI: 1.09-2.36) for women were positively associated with attaining the recommended level of physical activity. In women, cons (OR = 0.47; 95% CI: 0.33-0.67) and living in rural areas (OR = 0.50; 95% CI: 0.25-0.97) were negatively associated with meeting the physical activity recommendations. In the psychological, social, and

  16. Modeling Indicator Systems for Evaluating Environmental Sustainable Development Based on Factor Analysis

    Institute of Scientific and Technical Information of China (English)

    WU Hao; CHEN Xiaoling; HE Ying; HE Xiaorong; CAI Xiaobin; XU Keyan

    2006-01-01

    Indicator systems of environmental sustainable development in the Poyang Lake Basin are established from 51 elementary indexes by factor analysis, which is composed of four steps such as the factor model, the parameter estimation, the factor rotation and the factor score. Under the condition that the cumulative proportion is greater than 85%, 5 explicit factors of environmental sustainable development as well as its factor score by region are carried out. The result indicates some impact factors to the basin environmental in descending sort order are volume of water, volume of waste gas discharge, volume of solid wastes, the degree to comprehensive utilization of waste gas, waste water and solid wastes, the emission volume of waste gas, waste water and solid wastes. It is helpful and important to provide decision support for constituting sustainable development strategies and evaluate the sustainable development status of each city.

  17. IMPACT OF ENVIRONMENTAL FACTORS ON THE EFFICIENCY OF TAX ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    Marios Tsakas

    2014-05-01

    Full Text Available The study examines the performance of tax organizations in Greece, based on data obtained from a sample of 35 tax offices. Performance evaluation was conducted using DEA with bootstrap methods. In addition, Tobit regression analysis was employed to examine the environmental variables that impact on the efficiency performance of these tax offices. From the analysis, weaknesses, and management issues are derived from the tax offices inefficiency. The general conclusion is that a robust governance structure within the tax office operational framework is needed in order to improve organisational efficiency.

  18. Tackling the Relevance of Packaging in Life Cycle Assessment of Virgin Olive Oil and the Environmental Consequences of Regulation.

    Science.gov (United States)

    Navarro, Alejandra; Puig, Rita; Martí, Elena; Bala, Alba; Fullana-I-Palmer, Pere

    2018-04-12

    Production and consumption of olive oil is very important in Europe, being this product a basic element in the Mediterranean diet since long ago. The project objective is two-fold: a study of the contribution of virgin olive oils (VOOs) usual packaging to the whole life cycle of the product and a study of the environmental consequences of the Spanish Government regulation on VOO packaging. A life cycle assessment (LCA) according to ISO 14044 has been performed using the CML methodology for the impact assessment. The results show that the packaging influence varies from 2 to 300%, depending on the impact category and type of packaging (glass, tin or polyethylene terephtalate). Glass, which is related to higher quality perception by consumers, was found to be the most influencing material (due to its weight); however, this impact may be fairly reduced by applying ecodesign strategies (such as weight reduction and recycled-glass percentage increase). A new Spanish regulation on the mandatory use of non-refillable oilers in HORECA establishments (hotels, restaurants and caterings) aims to provide more quality assurance and better information to consumers; however, it was also found to mean a 74% increase in greenhouse gases emissions. This regulation was deeply discussed at European level and its application was withdraw due to consumers rejection, except for Spain. The findings of the present case study show that LCA and ecodesign should be important tools to be promoted and applied in policy making to reduce non-desirable consequences of regulation.

  19. Assessing environmental impacts of genetically modified plants on non-target organisms: The relevance of in planta studies.

    Science.gov (United States)

    Arpaia, Salvatore; Birch, A Nicholas E; Kiss, Jozsef; van Loon, Joop J A; Messéan, Antoine; Nuti, Marco; Perry, Joe N; Sweet, Jeremy B; Tebbe, Christoph C

    2017-04-01

    In legal frameworks worldwide, genetically modified plants (GMPs) are subjected to pre-market environmental risk assessment (ERA) with the aim of identifying potential effects on the environment. In the European Union, the EFSA Guidance Document introduces the rationale that GMPs, as well as their newly produced metabolites, represent the potential stressor to be evaluated during ERA. As a consequence, during several phases of ERA for cultivation purposes, it is considered necessary to use whole plants or plant parts in experimental protocols. The importance of in planta studies as a strategy to address impacts of GMPs on non-target organisms is demonstrated, to evaluate both effects due to the intended modification in plant phenotype (e.g. expression of Cry proteins) and effects due to unintended modifications in plant phenotype resulting from the transformation process (e.g. due to somaclonal variations or pleiotropic effects). In planta tests are also necessary for GMPs in which newly expressed metabolites cannot easily be studied in vitro. This paper reviews the scientific literature supporting the choice of in planta studies as a fundamental tool in ERA of GMPs in cultivation dossiers; the evidence indicates they can realistically mimic the ecological relationships occurring in their receiving environments and provide important insights into the biology and sustainable management of GMPs. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Global environmental ratings as an instrument of environmental policies: what factors determine the rank of Russia?

    Science.gov (United States)

    Alekseeva, Nina; Arshinova, Marina; Milanova, Elena

    2017-04-01

    Systems of global environmental rankings have emerged as a result of the escalating need for revealing the trends of ecological development for the world and for certain countries and regions. Both the environmental indicators and indexes and the ratings made on their basis are important for the assessment and forecast of the ecological situation in order to tackle the global and regional problems of sustainable development and help to translate the research findings into policy developments. Data sources for the global environmental ratings are most often the statistical information accumulated in databases of the international organizations (World Bank, World Resources Institute, FAO, WHO, etc.) These data are highly reliable and well-comparable that makes the ratings very objective. There are also good examples of using data of sociological polls, information from social networks, etc. The global environmental ratings are produced by the international organizations (World Bank, World Resources Institute, the UN Environment Program), non-governmental associations (WWF, Climate Action Network Europe (CAN-E), Germanwatch Nord-Süd-Initiative, Friends of the Earth, World Development Movement), research structures (scientific centers of the Yale and Colombian universities, the Oak-Ridge National Laboratory, the New Economic Foundation), and also individual experts, news agencies, etc. Thematic (sectoral) ratings cover various spheres from availability of resources and anthropogenic impact on environment components to nature protection policies and perception of environmental problems. The environmental indicators cover all parameters important for understanding the current ecological situation and the trajectories of its development (the DPSIR model, i.e. drivers, pressures, state, impact and response). Complex (integral) ratings are based on environmental indexes which are combined measurement tools using a complex of aggregated indicators based on a wide range of

  1. Effect of source and environmental factors on Rn-222 air concentration

    International Nuclear Information System (INIS)

    Mamoon, A.

    2005-01-01

    Rn-222(radon) air concentration depends on several factors. Some of the factors are source related and other factors are environmentally related. Because high levels of radon concentrations in air have potential health effects, it is important to study the impact of the various factors affecting radon air concentration. Laboratory scale investigations of the various factors affecting radon air concentration were carried out under controlled conditions that allow variation of the various variables

  2. Are endocrine disrupting compounds environmental risk factors for autism spectrum disorder?

    Science.gov (United States)

    Moosa, Amer; Shu, Henry; Sarachana, Tewarit; Hu, Valerie W

    2017-10-23

    Recent research on the etiology of autism spectrum disorder (ASD) has shifted in part from a singular focus on genetic causes to the involvement of environmental factors and their gene interactions. This shift in focus is a result of the rapidly increasing prevalence of ASD coupled with the incomplete penetrance of this disorder in monozygotic twins. One such area of environmentally focused research is the association of exposures to endocrine disrupting compounds (EDCs) with elevated risk for ASD. EDCs are exogenous chemicals that can alter endogenous hormone activity and homeostasis, thus potentially disrupting the action of sex and other natural hormones at all stages of human development. Inasmuch as sex hormones play a fundamental role in brain development and sexual differentiation, exposure to EDCs in utero during critical stages of development can have lasting neurological and other physiological influences on the developing fetus and, ultimately, the child as well as adult. This review will focus on the possible contributions of EDCs to autism risk and pathogenesis by first discussing the influence of endogenous sex hormones on the autistic phenotype, followed by a review of documented human exposures to EDCs and associations with behaviors relevant to ASD. Mechanistic links between EDC exposures and aberrant neurodevelopment and behaviors are then considered, with emphasis on EDC-induced transcriptional profiles derived from animal and cellular studies. Finally, this review will discuss possible mechanisms through which EDC exposure can lead to persistent changes in gene expression and phenotype, which may in turn contribute to transgenerational inheritance of ASD. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Is Hypovitaminosis D One of the Environmental Risk Factors for Multiple Sclerosis?

    Science.gov (United States)

    Pierrot-Deseilligny, Charles; Souberbielle, Jean-Claude

    2010-01-01

    The role of hypovitaminosis D as a possible risk factor for multiple sclerosis is reviewed. First, it is emphasized that hypovitaminosis D could be only one of the risk factors for multiple sclerosis and that numerous other environmental and genetic risk factors appear to interact and combine to trigger the disease. Secondly, the classical…

  4. Interlaboratory comparison of environmental relevant nuclides with spinach powder as sample medium; Vergleichspruefung mit Spinatpulver als Probenart fuer umweltrelevante Nuklide

    Energy Technology Data Exchange (ETDEWEB)

    Roos, N.; Tait, D. [Max Rubner-Institut, Kiel (Germany). Leitstelle fuer Boden, Bewuchs, Futtermittel und Nahrungsmittel pflanzlicher und tierischer Herkunft

    2014-01-20

    Spinach is cited as a representative medium for leafy vegetables in the Integrated Measurement and Information System for the surveillance of environmental radioactivity (IMIS) in Germany. Fresh spinach, however, is not suitable in interlaboratory comparisons on the determination of spiked radionuclides because of the difficulties in homogeneously distributing the radionuclides and attaining a known specific activity in the samples. In contrast, spinach powder is finely milled, so that homogeneous distribution and known specific activities of the nuclides are more readily achievable. For this interlaboratory comparison spinach powder was mixed with the pure beta emitter Sr-90 and the gamma-emitting nuclides I-131, Cs-134 and Cs-137. After homogenization samples were dispatched to 77 laboratories from Germany and other European countries (59 in Germany, 5 in Switzerland, 4 each in the UK and Austria, and one each in France, Italy, the Netherlands, Ireland and Luxembourg). In addition to the added nuclides participants had to determine the natural radionuclide K-40. The participants were instructed to use a fast method for the determination of dry matter (DM). To check the homogeneity of the nuclide distribution 14 samples of the labeled spinach powder were randomly selected and analyzed in the Coordinating Laboratory for the Surveillance of Radioactivity in the Environment of the Max Rubner-Institute (MRI). According to DIN 13528:2005 the samples showed sufficient homogeneity of the added nuclides. For the evaluation of the interlaboratory comparison the Physikalisch-Technische Bundesanstalt (PTB) determined reference values for the the specific activities (Bq per kg DM) of the gamma emitters. The values with the expanded uncertainties (k = 2) were as follows: I-131: 181 ± 6 Bq/kg; Cs-134: 34.4 ± 1.1 Bq/kg; Cs-137: 11.1 ± 0.4 Bq/kg; K-40: 1240 ± 40 Bq/kg. Since a reference value of the PTB for the specific activity of Sr-90 was not available the general average

  5. Characterization of Silver Nanoparticles under Environmentally Relevant Conditions Using Asymmetrical Flow Field-Flow Fractionation (AF4.

    Directory of Open Access Journals (Sweden)

    Min-Hee Jang

    Full Text Available The development of methods to monitor manufactured nanomaterials in the environment is one of the crucial areas for the assessment of their risk. More specifically, particle size analysis is a key element, because many properties of nanomaterial are size dependent. The sizing of nanomaterials in real environments is challenging due to their heterogeneity and reactivity with other environmental components. In this study, the fractionation and characterization of a mixture of polyvinylpyrrolidone-coated silver nanoparticles (PVP-AgNPs of three different sizes were investigated using asymmetrical flow field-flow fractionation (AF4 coupled with UV-Vis spectrophotometry. In particular, the effects of electrolyte composition and natural organic matter (NOM on the particle size and stability were evaluated. The fractogram peaks (i.e., stability of three different AgNPs decreased in the presence of both 10 mM NaCl and 10 mM CaCl2, while increased with increasing concentration of humic acid (HA. In addition, the hydrodynamic diameters of AgNPs in both electrolytes slightly increased with an increase of HA concentration, suggesting the adsorption (coating of HA onto the particle surface. It is also interesting to note that an increase in the particle size depended on the types of electrolyte, which could be explained by the conformational characteristics of the adsorbed HA layers. Consistent these results, AgNPs suspended in lake water containing relatively high concentration of organic carbon (TOC showed higher particle stability and larger particle size (i.e., by approximately 4 nm than those in river water. In conclusion, the application of AF4 coupled with highly sensitive detectors could be a powerful method to characterize nanoparticles in natural waters.

  6. Characterization of Silver Nanoparticles under Environmentally Relevant Conditions Using Asymmetrical Flow Field-Flow Fractionation (AF4)

    Science.gov (United States)

    Jang, Min-Hee; Lee, Seungho; Hwang, Yu Sik

    2015-01-01

    The development of methods to monitor manufactured nanomaterials in the environment is one of the crucial areas for the assessment of their risk. More specifically, particle size analysis is a key element, because many properties of nanomaterial are size dependent. The sizing of nanomaterials in real environments is challenging due to their heterogeneity and reactivity with other environmental components. In this study, the fractionation and characterization of a mixture of polyvinylpyrrolidone-coated silver nanoparticles (PVP-AgNPs) of three different sizes were investigated using asymmetrical flow field-flow fractionation (AF4) coupled with UV-Vis spectrophotometry. In particular, the effects of electrolyte composition and natural organic matter (NOM) on the particle size and stability were evaluated. The fractogram peaks (i.e., stability) of three different AgNPs decreased in the presence of both 10 mM NaCl and 10mM CaCl2, while increased with increasing concentration of humic acid (HA). In addition, the hydrodynamic diameters of AgNPs in both electrolytes slightly increased with an increase of HA concentration, suggesting the adsorption (coating) of HA onto the particle surface. It is also interesting to note that an increase in the particle size depended on the types of electrolyte, which could be explained by the conformational characteristics of the adsorbed HA layers. Consistent these results, AgNPs suspended in lake water containing relatively high concentration of organic carbon (TOC) showed higher particle stability and larger particle size (i.e., by approximately 4nm) than those in river water. In conclusion, the application of AF4 coupled with highly sensitive detectors could be a powerful method to characterize nanoparticles in natural waters. PMID:26575993

  7. Natural biogenic solid fuels - environmentally relevant characteristics and possible influences. Final report; Naturbelassene biogene Festbrennstoffe - umweltrelevante Eigenschaften und Einflussmoeglichkeiten. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Hartmann, H; Boehm, T; Maier, L [Bayerische Landesanstalt fuer Landtechnik, Friesing-Weihenstephan (Germany). Arbeitsgruppe Festbrennstoffe

    2000-09-01

    The focus of the research, however, lies in the analysis of biofuels which were collected under certain aspects from different field trials. Several influences were regarded: - The kind and level of potassium fertilisation (in collaboration with the University of Hohenheim) - the date of harvesting, tested for triticale (whole plants), festuca grass, set aside hay, and short rotation forestry (poplar and willow) - the rainfall induced leaching of pollutants from the fuel after cutting, tested for set aside hay, wheat straw and grain (whole plants). A structure for an SQL-database was designed, which allows to record a large range of information on each regarded fuel sample. Along with the actual analyses results, many additional characteristics can be regarded, in order to gain a precise specification of the respective biomass type and origin, the analysis method and the data source, including also the geographical location, special treatments and other criteria. An initial series of 1,238 data sets were entered until April 1999. This data were either generated during research projects or they were found in other primary sources from Germany and Austria. Additionally, the data base was broadened by a questioning among 200 relevant institutions or companies. From these sources the most reliable data were selected and applied. (orig.) [German] Den Schwerpunkt der vorliegenden Arbeit bildet jedoch die Analyse von biogenen Brennstoffen, die unter verschiedenen Gesichtspunkten aus verschiedenen Versuchsserien gewonnen wurden. Hierbei wurden unterschiedliche Einfluesse betrachtet bzw. gezielt abgestuft: - Art und Hoehe der Kaliumduengung bei Triticale und Feldgras (in Zusammenarbeit mit dem Institut fuer Pflanzenbau und Gruenlandwirtschaft der Universitaet Hohenheim) - Erntezeitpunkte bei Triticaleganzpflanzen, Rohrschwingel, Landschaftspflegeheu, Pappeln und Weiden - niederschlagsbedingte Auswaschung von Schadelementen nach der Ernte bei Landschaftspflegeheu

  8. The hazard assessment of nanostructured CeO{sub 2}-based mixed oxides on the zebrafish Danio rerio under environmentally relevant UV-A exposure

    Energy Technology Data Exchange (ETDEWEB)

    Jemec, Anita, E-mail: anita.jemec@bf.uni-lj.si [National Institute of Chemistry, Laboratory for Environmental Sciences and Engineering, Hajdrihova 19, SI-1001 Ljubljana (Slovenia); University of Ljubljana, Biotechnical Faculty, Department of Biology, Večna pot 111, SI-1000 Ljubljana (Slovenia); Djinović, Petar; Črnivec, Ilja Gasan Osojnik; Pintar, Albin [National Institute of Chemistry, Laboratory for Environmental Sciences and Engineering, Hajdrihova 19, SI-1001 Ljubljana (Slovenia)

    2015-02-15

    The effect of nanomaterials on biota under realistic environmental conditions is an important question. However, there is still a lack of knowledge on how different illumination conditions alter the toxicity of some photocatalytic nanomaterials. We have investigated how environmentally relevant UV-A exposure (intensity 8.50 ± 0.61 W/m{sup 2}, exposure dose 9.0 J/cm{sup 2}) affected the toxicity of cerium oxide (CeO{sub 2})-based nanostructured materials to the early-life stages of zebrafish Danio rerio. Pure cerium oxide (CeO{sub 2}), copper–cerium (CuO–CeO{sub 2}) (with a nominal 10, 15 and 20 mol.% CuO content), cerium–zirconium (CeO{sub 2}–ZrO{sub 2}) and nickel and cobalt (Ni–Co) deposited over CeO{sub 2}–ZrO{sub 2} were tested. It was found that under both illumination regimes, none of the tested materials affected the normal development or induced mortality of zebrafish early-life stages up to 100 mg/L. Only in the case of CuO–CeO{sub 2}, the growth of larvae was decreased (96 h LOEC values for CuCe10, CuCe15 and CuCe20 were 50, 50 and 10 mg/L, respectively). To conclude, CeO{sub 2}-based nanostructured materials are not severely toxic to zebrafish and environmentally relevant UV-A exposure does not enhance their toxicity. - Highlights: • CeO{sub 2}–ZrO{sub 2} nanomaterials and pure CeO{sub 2} (up to 100 mg/L) were not harmful to zebrafish. • Only CuO modified CeO{sub 2} affected the growth of zebrafish larvae. • UV-A radiation did not enhance the toxicity of tested nanomaterials.

  9. The interplay between environmental factors and DNA methylation in psychotic disorders : Environmental orchestration of the epigenome

    NARCIS (Netherlands)

    Houtepen, LC

    2016-01-01

    Introduction: Environmental exposures during early- life increase the risk of developing a psychotic disorder, but it remains unclear how early life events can have such persistent later life consequences. DNA methylation is the addition of a methyl group to a DNA base and is part of a group of

  10. Investigating Factors Affecting Environmental Behavior of Urban Residents: A Case Study in Tehran City- Iran

    OpenAIRE

    Khalil Kalantari; Hossein S.   Fami; Ali Asadi; H. M. Mohammadi

    2007-01-01

    Environmental problems such as air and water pollution, urban garbage and climate changes in urban areas are the results of human behavior. Only change in human behavior can reduce these environmental problems. Thus studying attitude and behavior of people is a precondition to change this situation. So the main objective of this study was to find out individual and social factors affecting environmental behavior of urban citizens. To achieve this objective a conceptual framework derived out f...

  11. Influence of bioregion and environmental factors on the growth, size ...

    African Journals Online (AJOL)

    2017-06-28

    Jun 28, 2017 ... factors on the productivity of beef cows is vital in the pursuit of improving ..... by bioregion differed from 10% for early life traits such as BW and ... et al., 2005), which may result in a negative energy balance (Bernabuccil ..... The authors declare that they have no conflicts of interest with regard to this work.

  12. Environmental factors and puberty timing: expert panel research needs

    DEFF Research Database (Denmark)

    Louis, G.M. Buck; Jr, L.E. Gray; Marcus, M.

    2008-01-01

    Serono Symposia International convened an expert panel to review the impact of environmental influences on the regulation of pubertal onset and progression while identifying critical data gaps and future research priorities. An expert panel reviewed the literature on endocrine-disrupting chemicals......, body size, and puberty. The panel concluded that available experimental animal and human data support a possible role of endocrine-disrupting chemicals and body size in relation to alterations in pubertal onset and progression in boys and girls. Critical data gaps prioritized for future research......, and (3) basic research to identify the primary signal(s) for the onset of gonadotropin-releasing hormone-dependent/central puberty and gonadotropin-releasing hormone-independent/peripheral puberty. Prospective studies of couples who are planning pregnancies or pregnant women are needed to capture...

  13. Is Environmental Dematerialization An Active Factor Of The Sustainable Development?

    Directory of Open Access Journals (Sweden)

    Florin Razvan BĂLĂȘESCU

    2012-09-01

    Full Text Available As it is known, sustainable development reveals economic, social and ecologic aspects circumscribed to the sustainability of the stock of natural capital and to the energy matter entropic flows which affects the relation environment-economy-society in terms of externalities and of the socio-industrial metabolism. Thus, taking into account the principles of the technical-economic rationality and integrative socio-ecologic complexity, dematerialization is a concept, an instrument and a vector carrying socio-economic values based on the natural and social sciences. In this framework environmental dematerialization reveals the issue of socio- economic energetic centres - a result of relationship between nature and human rational sensible free will determinism.

  14. Environmental impact and risk assessments and key factors contributing to the overall uncertainties.

    Science.gov (United States)

    Salbu, Brit

    2016-01-01

    There is a significant number of nuclear and radiological sources that have contributed, are still contributing, or have the potential to contribute to radioactive contamination of the environment in the future. To protect the environment from radioactive contamination, impact and risk assessments are performed prior to or during a release event, short or long term after deposition or prior and after implementation of countermeasures. When environmental impact and risks are assessed, however, a series of factors will contribute to the overall uncertainties. To provide environmental impact and risk assessments, information on processes, kinetics and a series of input variables is needed. Adding problems such as variability, questionable assumptions, gaps in knowledge, extrapolations and poor conceptual model structures, a series of factors are contributing to large and often unacceptable uncertainties in impact and risk assessments. Information on the source term and the release scenario is an essential starting point in impact and risk models; the source determines activity concentrations and atom ratios of radionuclides released, while the release scenario determine the physico-chemical forms of released radionuclides such as particle size distribution, structure and density. Releases will most often contain other contaminants such as metals, and due to interactions, contaminated sites should be assessed as a multiple stressor scenario. Following deposition, a series of stressors, interactions and processes will influence the ecosystem transfer of radionuclide species and thereby influence biological uptake (toxicokinetics) and responses (toxicodynamics) in exposed organisms. Due to the variety of biological species, extrapolation is frequently needed to fill gaps in knowledge e.g., from effects to no effects, from effects in one organism to others, from one stressor to mixtures. Most toxtests are, however, performed as short term exposure of adult organisms

  15. Factor Analysis on the Factors that Influencing Rural Environmental Pollution in the Hilly Area of Sichuan Province,China

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    By using factor analysis method and establishing analysis indicator system from four aspects including crop production,poultry farming,rural life and township enterprises,the difference,features,and types of factors influencing the rural environmental pollution in the hilly area in Sichuan Province,China.Results prove that the major factor influencing rural environmental pollution in the study area is livestock and poultry breeding,flowed by crop planting,rural life,and township enterprises.Hence future pollution prevention and control should set about from livestock and poultry breeding.Meanwhile,attention should be paid to the prevention and control of rural environmental pollution caused by rural life and township enterprise production.

  16. Factors in Organisational Environmental Management System Implementation – Developed vs. Developing Country Contexts

    OpenAIRE

    Kola-Lawal, Constance; Wood, Mike; Alo, Babajide; Clark, Andrew

    2014-01-01

    Country specificities and national cultures influence Environmental Management Systems (EMS) implementation and pro-environmental behaviour in organisations. Previous studies have focused on organisations in developed or emerging economies, creating a need to establish the extent to which findings are applicable to developing counterparts. This paper presents EMS implementation from a developing country perspective, reporting on EMS implementation factors (drivers, benefits, barriers) affecti...

  17. EVALUATING KEY ENVIRONMENTAL RISK FACTORS FOR POLLUTION AT INTERNATIONAL PORTS IN TAIWAN

    Directory of Open Access Journals (Sweden)

    Kuan-Hao Chang

    2017-01-01

    Full Text Available The main purpose of this paper is to use the fuzzy analytic hierarchy process (FAHP approach to evaluate the key environmental risk factors for pollution at international ports in Taiwan. Relying on the literature and experts’ opinions, a hierarchical structure with three risk aspects and thirteen risk factors is first constructed, and a FAHP model then proposed. Based on data from the AHP experts’ questionnaires, we use the FAHP approach to determine key environmental risk factors. Finally, the results show that: (1 Air pollution is the most important aspect of environmental pollution at international ports in Taiwan. (2 In order of relative importance, the top five key environmental risk factors for pollution at international ports in Taiwan are the oil leaks from ships, volatile organic compounds (VOCs, exhaust emissions from ships at berth, harmful coatings on ships' hulls, and ships' failure to use low-pollution fuel. Furthermore, some discussions are provided for port authority in Taiwan.

  18. Environmental factors and dam characteristics associated with insulin sensitivity and insulin secretion in newborn Holstein calves

    International Nuclear Information System (INIS)

    Kamal, M.M.; Van Eetvelde, M.; Bogaert, H.; Hostens, M.; Vandaele, L.; Shamsuddin, M.; Opsomer, G.

    2015-01-01

    The objective of the present retrospective cohort study was to evaluate potential associations between environmental factors and dam characteristics, including level of milk production during gestation, and insulin traits in newborn Holstein calves

  19. Modelling nutrient concentration to determine the environmental factors influencing grass quality

    CSIR Research Space (South Africa)

    Dudeni-Tlhone, N

    2010-10-01

    Full Text Available This paper uses the spatial and the least squares (Analysis of Covariance-ANCOVA) regression methods to evaluate the important environmental factors in estimating quality grass for grazing (based on the nitrogen (N) content in grass...

  20. Environmental and Life Style Factors in Relation to Male Reproductive Disorders

    DEFF Research Database (Denmark)

    Krysiak-Baltyn, Konrad

    on the environmental aspects of TDS, generating further support for the hypothesis that environmental factors may play a critical role in the observed trends. This thesis is divided into four parts. In the first part I introduce male reproductive disorders and the current state of affairs. In the second part, I focus......During the past four decades, the incidence rates of testicular cancer and other male reproductive disorders have been increasing at a rapid rate, predominantly in developed and industrialized countries. This increase is considered too great to be explained by genetic factors alone, and thus...... environmental factors have strongly been suspected to play a major role. There is a large amount of clinical research which has tried to pinpoint the mechanism of action for this trend. Although the exact mechanism of action has not been elucidated, a number of genetic factors as well as environmental chemicals...

  1. Chaetognath community and their responses to varying environmental factors in the northern Indian ocean.

    Digital Repository Service at National Institute of Oceanography (India)

    Kusum, K.K.; Vineetha, G.; Raveendran, T.V.; Nair, V.R.; Muraleedharan, K.R.; Achuthankutty, C.T.; Joseph, T.

    The ecology of the chaetognath community and its relation to varying environmental factors were studied in the eastern half of the northern Indian Ocean. Analysis of data from two major oceanographic programmes performed over four decades apart...

  2. The Contribution of Home, Neighbourhood and School Environmental Factors in Explaining Physical Activity among Adolescents

    International Nuclear Information System (INIS)

    Haerens, L.; Deforche, B.; Cardon, G.; Bourdeaudhuij, I.D.; Craeynest, M.; Maes, L.

    2010-01-01

    The present study aimed at investigating the influence of home, neighbourhood and school environmental factors on adolescents' engagement in self-reported extracurricular physical activity and leisure time sports and on MVPA objectively measured by accelerometers. Environmental factors were assessed using questionnaires. Gender specific hierarchical regression analyses were conducted, with demographic variables entered in the first block, and environmental, psychosocial factors and interactions terms entered in the second block. Participation in extracurricular activities at school was positively related to the number of organized activities and the provision of supervision. Perceived accessibility of neighborhood facilities was not related to engagement in leisure time sports, whereas the availability of sedentary and physical activity equipment was. Findings were generally supportive of ecological theories stating that behaviors are influenced by personal and environmental factors that are constantly interacting.

  3. Genotypes in relation to phenotypic appearance and exposure to environmental factors in Graves' hyperthyroidism

    NARCIS (Netherlands)

    Vos, Xander G.; Endert, Erik; Tijssen, Jan G. P.; Wiersinga, Wilmar M.

    2012-01-01

    Background: Genetic polymorphisms and environmental factors are both involved in the pathogenesis of Graves' disease, but their interaction and effect on Graves' phenotypes have scarcely been investigated. Objective: To test the hypothesis that subjects with susceptibility genotypes develop more

  4. Pedestrian road traffic injuries in urban Peruvian children and adolescents: case control analyses of personal and environmental risk factors.

    Directory of Open Access Journals (Sweden)

    Joseph Donroe

    2008-09-01

    Full Text Available Child pedestrian road traffic injuries (RTIs are an important cause of death and disability in poorer nations, however RTI prevention strategies in those countries largely draw upon studies conducted in wealthier countries. This research investigated personal and environmental risk factors for child pedestrian RTIs relevant to an urban, developing world setting.This is a case control study of personal and environmental risk factors for child pedestrian RTIs in San Juan de Miraflores, Lima, Perú. The analysis of personal risk factors included 100 cases of serious pedestrian RTIs and 200 age and gender matched controls. Demographic, socioeconomic, and injury data were collected. The environmental risk factor study evaluated vehicle and pedestrian movement and infrastructure at the sites in which 40 of the above case RTIs occurred and 80 control sites.After adjustment, factors associated with increased risk of child pedestrian RTIs included high vehicle volume (OR 7.88, 95%CI 1.97-31.52, absent lane demarcations (OR 6.59, 95% CI 1.65-26.26, high vehicle speed (OR 5.35, 95%CI 1.55-18.54, high street vendor density (OR 1.25, 95%CI 1.01-1.55, and more children living in the home (OR 1.25, 95%CI 1.00-1.56. Protective factors included more hours/day spent in school (OR 0.52, 95%CI 0.33-0.82 and years of family residence in the same home (OR 0.97, 95%CI 0.95-0.99.Reducing traffic volumes and speeds, limiting the number of street vendors on a given stretch of road, and improving lane demarcation should be evaluated as components of child pedestrian RTI interventions in poorer countries.

  5. Causal inference between bioavailability of heavy metals and environmental factors in a large-scale region.

    Science.gov (United States)

    Liu, Yuqiong; Du, Qingyun; Wang, Qi; Yu, Huanyun; Liu, Jianfeng; Tian, Yu; Chang, Chunying; Lei, Jing

    2017-07-01

    The causation between bioavailability of heavy metals and environmental factors are generally obtained from field experiments at local scales at present, and lack sufficient evidence from large scales. However, inferring causation between bioavailability of heavy metals and environmental factors across large-scale regions is challenging. Because the conventional correlation-based approaches used for causation assessments across large-scale regions, at the expense of actual causation, can result in spurious insights. In this study, a general approach framework, Intervention calculus when the directed acyclic graph (DAG) is absent (IDA) combined with the backdoor criterion (BC), was introduced to identify causation between the bioavailability of heavy metals and the potential environmental factors across large-scale regions. We take the Pearl River Delta (PRD) in China as a case study. The causal structures and effects were identified based on the concentrations of heavy metals (Zn, As, Cu, Hg, Pb, Cr, Ni and Cd) in soil (0-20 cm depth) and vegetable (lettuce) and 40 environmental factors (soil properties, extractable heavy metals and weathering indices) in 94 samples across the PRD. Results show that the bioavailability of heavy metals (Cd, Zn, Cr, Ni and As) was causally influenced by soil properties and soil weathering factors, whereas no causal factor impacted the bioavailability of Cu, Hg and Pb. No latent factor was found between the bioavailability of heavy metals and environmental factors. The causation between the bioavailability of heavy metals and environmental factors at field experiments is consistent with that on a large scale. The IDA combined with the BC provides a powerful tool to identify causation between the bioavailability of heavy metals and environmental factors across large-scale regions. Causal inference in a large system with the dynamic changes has great implications for system-based risk management. Copyright © 2017 Elsevier Ltd. All

  6. Suppression of bremsstrahlung and pair production due to environmental factors

    International Nuclear Information System (INIS)

    Klein, Spencer

    1999-01-01

    The environment in which bremsstrahlung and pair creation occurs can strongly affect cross sections for these processes. Because ultrarelativistic electromagnetic interactions involve very small longitudinal momentum transfers, the reactions occur gradually, spread over long distances. During this time, even relatively weak factors can accumulate enough to disrupt the interaction. In the Landau-Pomeranchuk-Migdal effect, multiple scattering reduces the bremsstrahlung and pair production cross section. This review will discuss this and a variety of other factors that can suppress bremsstrahlung and pair production, as well as related effects involving beamstrahlung and QCD processes. After surveying different theoretical approaches, experimental measurements will be covered. Recent accurate measurements by the SLAC E-146 Collaboration will be highlighted, along with several recent theoretical works relating to the experiment. (c) 1999 The American Physical Society

  7. The effect of environmental factors on job Performance using manual and mental tests

    Directory of Open Access Journals (Sweden)

    F. Golbabaei

    2014-07-01

    Conclusion: Finding of the present research manifested that increase in noise and heat stress and also reduction in lighting lessen the speed of manual tests and time and accuracy of mathematical calculations. Therefore this result confirm the effects of various environmental factors on individuals’ job performance, in a way that by variation of different environmental factors, time of manual test and time and accuracy of mental tests would be changed.

  8. Standard protocol for evaluation of environmental transfer factors around NPP sites

    International Nuclear Information System (INIS)

    Hegde, A.G.; Verma, P.C.; Rao, D.D.

    2009-01-01

    This document presents the standard procedures for evaluation of site specific environmental transfer factors around NPP sites. The scope of this document is to provide standard protocol to be followed for evaluation of environmental transfer factors around NPP sites. The studies on transfer factors are being carried out at various NPP sites under DAE-BRNS projects for evaluation of site specific transfer factors for radionuclides released from power plants. This document contains a common methodology in terms of sampling, processing, measurements and analysis of elemental/radionuclides, while keeping the site specific requirements also in place. (author)

  9. Human and bovine viruses in the Milwaukee River Watershed: hydrologically relevant representation and relations with environmental variables

    Science.gov (United States)

    Corsi, Steven R.; Borchardt, M. A.; Spencer, S. K.; Hughes, Peter E.; Baldwin, Austin K.

    2014-01-01

    To examine the occurrence, hydrologic variability, and seasonal variability of human and bovine viruses in surface water, three stream locations were monitored in the Milwaukee River watershed in Wisconsin, USA, from February 2007 through June 2008. Monitoring sites included an urban subwatershed, a rural subwatershed, and the Milwaukee River at the mouth. To collect samples that characterize variability throughout changing hydrologic periods, a process control system was developed for unattended, large-volume (56–2800 L) filtration over extended durations. This system provided flow-weighted mean concentrations during runoff and extended (24-h) low-flow periods. Human viruses and bovine viruses were detected by real-time qPCR in 49% and 41% of samples (n = 63), respectively. All human viruses analyzed were detected at least once including adenovirus (40% of samples), GI norovirus (10%), enterovirus (8%), rotavirus (6%), GII norovirus (1.6%) and hepatitis A virus (1.6%). Three of seven bovine viruses analyzed were detected including bovine polyomavirus (32%), bovine rotavirus (19%), and bovine viral diarrhea virus type 1 (5%). Human viruses were present in 63% of runoff samples resulting from precipitation and snowmelt, and 20% of low-flow samples. Maximum human virus concentrations exceeded 300 genomic copies/L. Bovine viruses were present in 46% of runoff samples resulting from precipitation and snowmelt and 14% of low-flow samples. The maximum bovine virus concentration was 11 genomic copies/L. Statistical modeling indicated that stream flow, precipitation, and season explained the variability of human viruses in the watershed, and hydrologic condition (runoff event or low-flow) and season explained the variability of the sum of human and bovine viruses; however, no model was identified that could explain the variability of bovine viruses alone. Understanding the factors that affect virus fate and transport in rivers will aid watershed management for minimizing

  10. [Academic discussion of adverse reaction of clinical trials of new traditional Chinese medicines and relevant influencing factors].

    Science.gov (United States)

    Wang, Wen-ping; Yu, Ming; Wang, Li; Jiang, Xi-ren; Li, Xiao-bin; Wang, Hua-wei; Cao, Ying; Liu, Kai; Huang, Lu-qi

    2015-01-01

    Data of clinical trial projects involved by clinical trial institutions certified by the State Food and Drug Administration from 2002 to November 2012 were collected to summarize adverse reactions in project summary/statistical reports, analyze the rate of adverse reactions of clinical trials of new traditional Chinese medicines and relevant influencing factors, and increase the awareness of the safety of new traditional Chinese medicines. A total of 73 050 cases in 209 projects of 14 specialties were collected, including 49 689 cases in the new traditional Chinese medicine group and 271 adverse reaction cases, with an incidence rate of adverse reactions at 0.55%. The adverse reaction rate in 3 months 0.63% for injection > 0.50% for oral. In the administration of only the test drug, the adverse reaction rate of patches was the highest (2.68%), whereas that of aerosols and suppositories was lowest (0). In the combined administration of the test drug and the simulation agent, the adverse reaction rate of external test patch + capsule was the highest (3.38%), whereas that of capsule + oral liquid, pills + granules, tablets + oral liquid, tablets + pills, tablet + capsule was the lowest (0). In the administration of only the test drug, the adverse reaction rate was 0.47%; In the combined administration with simulation agent (drug volume increase), the adverse reaction rate was 0.74%. Different doses caused adverse reaction different rates; The adverse reaction rate of drugs with whole-course dose between 1 100-1 200 g was the highest (3.36%), that for whole-course doses of 500-600, 900-1 000, 1 400-1 500, 1 600-1 700, 1 800-1 900 g was the lowest (0). In conclusion, the adverse reaction rate of new traditional Chinese medicines was still up to 0.55%, with the adverse reaction rate between 0.47% and 0.72% over the 11 years, without significant difference in each year. The adverse reaction rate was closely related to course of treatment, approach of administration

  11. Evaluation and comparison of benchmark QSAR models to predict a relevant REACH endpoint: The bioconcentration factor (BCF).

    Science.gov (United States)

    Gissi, Andrea; Lombardo, Anna; Roncaglioni, Alessandra; Gadaleta, Domenico; Mangiatordi, Giuseppe Felice; Nicolotti, Orazio; Benfenati, Emilio

    2015-02-01

    The bioconcentration factor (BCF) is an important bioaccumulation hazard assessment metric in many regulatory contexts. Its assessment is required by the REACH regulation (Registration, Evaluation, Authorization and Restriction of Chemicals) and by CLP (Classification, Labeling and Packaging). We challenged nine well-known and widely used BCF QSAR models against 851 compounds stored in an ad-hoc created database. The goodness of the regression analysis was assessed by considering the determination coefficient (R(2)) and the Root Mean Square Error (RMSE); Cooper's statistics and Matthew's Correlation Coefficient (MCC) were calculated for all the thresholds relevant for regulatory purposes (i.e. 100L/kg for Chemical Safety Assessment; 500L/kg for Classification and Labeling; 2000 and 5000L/kg for Persistent, Bioaccumulative and Toxic (PBT) and very Persistent, very Bioaccumulative (vPvB) assessment) to assess the classification, with particular attention to the models' ability to control the occurrence of false negatives. As a first step, statistical analysis was performed for the predictions of the entire dataset; R(2)>0.70 was obtained using CORAL, T.E.S.T. and EPISuite Arnot-Gobas models. As classifiers, ACD and logP-based equations were the best in terms of sensitivity, ranging from 0.75 to 0.94. External compound predictions were carried out for the models that had their own training sets. CORAL model returned the best performance (R(2)ext=0.59), followed by the EPISuite Meylan model (R(2)ext=0.58). The latter gave also the highest sensitivity on external compounds with values from 0.55 to 0.85, depending on the thresholds. Statistics were also compiled for compounds falling into the models Applicability Domain (AD), giving better performances. In this respect, VEGA CAESAR was the best model in terms of regression (R(2)=0.94) and classification (average sensitivity>0.80). This model also showed the best regression (R(2)=0.85) and sensitivity (average>0.70) for

  12. [Interrelationships between soil fauna and soil environmental factors in China: research advance].

    Science.gov (United States)

    Wang, Yi; Wei, Wei; Yang, Xing-zhong; Chen, Li-ding; Yang, Lei

    2010-09-01

    Soil fauna has close relations with various environmental factors in soil ecosystem. To explore the interrelationships between soil fauna and soil environmental factors is of vital importance to deep understand the dynamics of soil ecosystem and to assess the functioning of the ecosystem. The environmental factors affecting soil fauna can be classified as soil properties and soil external environment. The former contains soil basic physical and chemical properties, soil moisture, and soil pollution. The latter includes vegetation, land use type, landform, and climate, etc. From these aspects, this paper summarized the published literatures in China on the interrelationships between soil fauna and soil environmental factors. It was considered that several problems were existed in related studies, e.g., fewer researches were made in integrating soil fauna's bio-indicator function, research methods were needed to be improved, and the studies on the multi-environmental factors and their large scale spatial-temporal variability were in deficiency. Corresponding suggestions were proposed, i.e., more work should be done according to the practical needs, advanced experiences from abroad should be referenced, and comprehensive studies on multi-environmental factors and long-term monitoring should be conducted on large scale areas.

  13. Regional scale soil salinity assessment using remote sensing based environmental factors and vegetation indicators

    Science.gov (United States)

    Ma, Ligang; Ma, Fenglan; Li, Jiadan; Gu, Qing; Yang, Shengtian; Ding, Jianli

    2017-04-01

    Land degradation, specifically soil salinization has rendered large areas of China west sterile and unproductive while diminishing the productivity of adjacent lands and other areas where salting is less severe. Up to now despite decades of research in soil mapping, few accurate and up-to-date information on the spatial extent and variability of soil salinity are available for large geographic regions. This study explores the po-tentials of assessing soil salinity via linear and random forest modeling of remote sensing based environmental factors and indirect indicators. A case study is presented for the arid oases of Tarim and Junggar Basin, Xinjiang, China using time series land surface temperature (LST), evapotranspiration (ET), TRMM precipitation (TRM), DEM product and vegetation indexes as well as their second order products. In par-ticular, the location of the oasis, the best feature sets, different salinity degrees and modeling approaches were fully examined. All constructed models were evaluated for their fit to the whole data set and their performance in a leave-one-field-out spatial cross-validation. In addition, the Kruskal-Wallis rank test was adopted for the statis-tical comparison of different models. Overall, the random forest model outperformed the linear model for the two basins, all salinity degrees and datasets. As for feature set, LST and ET were consistently identified to be the most important factors for two ba-sins while the contribution of vegetation indexes vary with location. What's more, models performances are promising for the salinity ranges that are most relevant to agricultural productivity.

  14. Prevalence of sarcoidosis in Switzerland is associated with environmental factors.

    Science.gov (United States)

    Deubelbeiss, U; Gemperli, A; Schindler, C; Baty, F; Brutsche, M H

    2010-05-01

    The current study aimed to investigate incidence, prevalence and regional distribution of sarcoidosis in Switzerland with respect to environmental exposures. All sarcoidosis patients hospitalised between 2002 and 2005 were identified from the Swiss hospital statistics from the Swiss Federal Office for Statistics (Neuchâtel, Switzerland). Regional exposure characteristics included the regional distribution of different industrial sectors, agriculture and air quality. Co-inertia analysis, as well as a generalised linear model, was applied. The prevalence of "ever-in-life" diagnosed sarcoidosis, currently active sarcoidosis and sarcoidosis requiring hospitalisation was 121 (95% CI 93-149), 44 (95% CI 34-54) and 16 (95% CI 10-22) per 100,000 inhabitants, respectively. The mean annual incidence of sarcoidosis was 7 (95% CI 5-11) per 100,000 inhabitants. The regional workforce in the metal industry, water supply, air transport factories and the area of potato production, artificial meadows (grassland) and bread grains were positively associated with the frequency of sarcoidosis. The prevalence of sarcoidosis was higher than assumed based on former international estimates. Higher frequency was found in regions with metal industry and intense agriculture, especially production of potatoes, bread grains and artificial meadows.

  15. Particle size - An important factor in environmental consequence modeling

    International Nuclear Information System (INIS)

    Yuan, Y.C.; MacFarlane, D.

    1991-01-01

    Most available environmental transport and dosimetry codes for radiological consequence analysis are designed primarily for estimating dose and health consequences to specific off-site individuals as well as the population as a whole from nuclear facilities operating under either normal or accident conditions. Models developed for these types of analyses are generally based on assumptions that the receptors are at great distances (several kilometers), and the releases are prolonged and filtered. This allows the use of simplified approaches such as averaged meteorological conditions and the use of a single (small) particle size for atmospheric transport and dosimetry analysis. Source depletion from particle settling, settle-out, and deposition is often ignored. This paper estimates the effects of large particles on the resulting dose consequences from an atmospheric release. The computer program AI-RISK has been developed to perform multiparticle-sized atmospheric transport, dose, and pathway analyses for estimating potential human health consequences from the accidental release of radioactive materials. The program was originally developed to facilitate comprehensive analyses of health consequences, ground contamination, and cleanup associated with possible energetic chemical reactions in high-level radioactive waste (HLW) tanks at a US Department of Energy site

  16. Associations of Environmental Factors With Quality of Life in Older Adults.

    Science.gov (United States)

    Gobbens, Robbert J J; van Assen, Marcel A L M

    2018-01-18

    Environmental factors play an important role in the quality of life of older people who often have difficulty maintaining physical, psychological, and social functioning. In this study, we aimed at (a) developing a measurement instrument assessing the factors of older adults' perceptions of their environment, (b) examining the associations of these environmental factors with quality of life domains physical health, psychological, social relations, and environmental, controlling for background characteristics. Associations between environmental factors and quality of life domains were examined in a cross-sectional study using a sample of 1,031 Dutch people aged 65 years and older. Participants completed a Web-based questionnaire, the "Senioren Barometer." Forty-two questions on environmental factors were asked, and quality of life domains were assessed by the WHOQOL-BREF. Seven scales (comprising 3-9 items) of environment were constructed-housing, facilities, nuisance, residents, neighborhood, stench/noise, and traffic. All quality of life domains (physical, psychological, social, environmental) were associated with at least one environmental scale. Housing, residents, and nuisance were associated with 4, 3, and 2 domains, respectively. Facilities, neighborhood, stench/noise, and traffic were associated only with quality of life environmental. This study showed that multiple environmental factors are associated with quality of life in older people. To support independent living in older people health and social care professionals and policymakers may need to carry out interventions, in particular focusing on housing, residents, and nuisance. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  17. Environmental Factors and Myopia: Paradoxes and Prospects for Prevention.

    Science.gov (United States)

    Rose, Kathryn Ailsa; French, Amanda Nicole; Morgan, Ian George

    The prevalence of myopia in developed countries in East and Southeast Asia has increased to more than 80% in children completing schooling, whereas that of high myopia has increased to 10%-20%. This poses significant challenges for correction of refractive errors and the management of pathological high myopia. Prevention is therefore an important priority. Myopia is etiologically heterogeneous, with a low level of myopia of clearly genetic origins that appears without exposure to risk factors. The big increases have occurred in school myopia, driven by increasing educational pressures in combination with limited amounts of time spent outdoors. The rise in prevalence of high myopia has an unusual pattern of development, with increases in prevalence first appearing at approximately age 11. This pattern suggests that the increasing prevalence of high myopia is because of progression of myopia in children who became myopic at approximately age 6 or 7 because age-specific progression rates typical of East Asia will take these children to the threshold for high myopia in 5 to 6 years. This high myopia seems to be acquired, having an association with educational parameters, whereas high myopia in previous generations tended to be genetic in origin. Increased time outdoors can counter the effects of increased nearwork and reduce the impact of parental myopia, reducing the onset of myopia, and this approach has been validated in 3 randomized controlled trials. Other proposed risk factors need further work to demonstrate that they are independent and can be modified to reduce the onset of myopia.

  18. Meta-Analysis of Comparing Personal and Environmental Factors Effective in Addiction Relapse (Iran, 2004 -2012

    Directory of Open Access Journals (Sweden)

    s Safari

    2014-12-01

    Full Text Available Objective: This As a meta-analysis, this study aimed to integrate different studies and investigate the impact of individual and environmental factors on the reappearance of addiction in quitted people. Method: This study is a meta-analysis which uses Hunter and Schmidt approach. For this purpose, 28 out of 42 studies enjoying acceptable methodologies were selected, upon which the meta-analysis was conducted. A meta-analysis checklist was the research instrument. Using summary of the study results, the researcher manually calculated effect size and interpreted it based on the meta-analysis approach and Cohen’s table. Findings: Results revealed that the effect size of environmental factors on addiction relapse was 0.64 while it was obtained 0.41 for individual factors on addiction relapse. Conclusion: According to Cohen’s table, the effect sizes are evaluated as moderate and high for individual factors and environmental factors on addiction relapse, respectively.

  19. Environmental Factors Affecting the Strength Characteristics of Modified Resin Mortars

    Science.gov (United States)

    Debska, Bernardeta; Licholai, Lech

    2017-12-01

    Resin concretes are composites in which a cement binder has been completely replaced by a synthetic resin. These materials are a good choice for the construction industry, especially in solutions requiring high strength, fast curing and durability. Polymer mortars are mainly used for the manufacture of industrial floors and prefabricated products such as tanks for aggressive chemicals, sewage pipes, or road and bridge drainage systems, as well as for the repair of damaged concrete structures. In all these applications, the strength and high chemical resistance of the applied material solutions are of key importance. It is particularly crucial to obtain information on how resin composites behave when exposed to aggressive agents over extended periods of time. It is also very important to use waste materials in order to obtain resin composites, as these activities are very well inscribed in the idea of environmental protection and meet the criteria of sustainable construction. The mortars described in this article meet the above principles. The article presents how the compressive strength of glycolyzate-modified epoxy mortars, obtained with the use of poly(ethylene terephthalate), changes after they are immersed in 10% sodium chloride solution. Sodium chloride solution was chosen due to the prospective applicability of the tested composites as repair materials used for e.g. bridges or overpasses that are exposed to this salt solution in wintertime. Changes in the properties of the composite samples were monitored over the period of one year. Statistical analysis of the test results was carried out with the use of Statistica programme. The module available in the mentioned program called Nonparametric Statistics - Comparing multiple independent samples made it possible to check the monitoring times during which the compressive strength values differed significantly. The obtained results allowed for determining the equation of the function approximating the course of

  20. How fear-relevant illusory correlations might develop and persist in anxiety disorders: A model of contributing factors.

    Science.gov (United States)

    Wiemer, Julian; Pauli, Paul

    2016-12-01

    Fear-relevant illusory correlations (ICs) are defined as the overestimation of the relationship between a fear-relevant stimulus and aversive consequences. ICs reflect biased cognitions affecting the learning and unlearning of fear in anxiety disorders, and a deeper understanding might help to improve treatment. A model for the maintenance of ICs is proposed that highlights the importance of amplified aversiveness and salience of fear-relevant outcomes, impaired executive contingency monitoring and an availability heuristic. The model explains why ICs are enhanced in high fearful individuals and allows for some implications that might be applied to augment the effectiveness of cognitive behavior therapy, such as emotion regulation and the direction of attention to non-aversive experiences. Finally, we suggest possible future research directions and an alternative measure of ICs. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. An indicator for effects of organic toxicants on lotic invertebrate communities: Independence of confounding environmental factors over an extensive river continuum

    International Nuclear Information System (INIS)

    Beketov, Mikhail A.; Liess, Matthias

    2008-01-01

    Distinguishing between effects of natural and anthropogenic environmental factors on ecosystems is a fundamental problem in environmental science. In river systems the longitudinal gradient of environmental factors is one of the most relevant sources of dissimilarity between communities that could be confounded with anthropogenic disturbances. To test the hypothesis that in macroinvertebrate communities the distribution of species' sensitivity to organic toxicants is independent of natural longitudinal factors, but depends on contamination with organic toxicants, we analysed the relationship between community sensitivity SPEAR organic (average community sensitivity to organic toxicants) and natural and anthropogenic environmental factors in a large-scale river system, from alpine streams to a lowland river. The results show that SPEAR organic is largely independent of natural longitudinal factors, but strongly dependent on contamination with organic toxicants (petrochemicals and synthetic surfactants). Usage of SPEAR organic as a stressor-specific longitude-independent measure will facilitate detection of community disturbance by organic toxicants. - Indicator for organic toxicants at community level can be independent of natural environmental factors

  2. Contaminant mixtures and repoductive health: Developmental toxicity effects in rats after mixed exposure to environmentally relevant endocrine disrupting chemicals, with focus on effects in females

    DEFF Research Database (Denmark)

    Jacobsen, Pernille Rosenskjold; Christiansen, Sofie; Hass, Ulla

    proposed that a similar syndrome, called the ovarian dysgenesis syndrome (ODS), exists for females. This syndrome encompasses alterations in reproductive development caused by chemical exposure in sensitive windows of development that may result in fecundity impairments, gravid diseases, gynecological...... disorders or later onset adult diseases. However, experimental evidence on the effects of developmental exposure to environmentally relevant endocrine disrupting chemicals in females has been missing attention. Since chemical exposure can affect female reproductive development it is important to investigate......, mixtures were modeled based on high end human intakes, and the project involved two developmental mixture studies in rats, called Contamed 1 and 2. In these studies 13 chemicals where data on in vivo endocrine disrupting effects and information on human exposures was available, were selected. The tested...

  3. Internal and external environmental factors affecting the performance of hospital-based home nursing care.

    Science.gov (United States)

    Noh, J-W; Kwon, Y-D; Yoon, S-J; Hwang, J-I

    2011-06-01

    Numerous studies on HNC services have been carried out by signifying their needs, efficiency and effectiveness. However, no study has ever been performed to determine the critical factors associated with HNC's positive results despite the deluge of positive studies on the service. This study included all of the 89 training hospitals that were practising HNC service in Korea as of November 2006. The input factors affecting the performance were classified as either internal or external environmental factors. This analysis was conducted to understand the impact that the corresponding factors had on performance. Data were analysed by using multiple linear regressions. The internal and external environment variables affected the performance of HNC based on univariate analysis. The meaningful variables were internal environmental factors. Specifically, managerial resource (the number of operating beds and the outpatient/inpatient ratio) were meaningful when the multiple linear regression analysis was performed. Indeed, the importance of organizational culture (the passion of HNC nurses) was significant. This study, considering the limited market size of Korea, illustrates that the critical factor for the development of hospital-led HNC lies with internal environmental factors rather than external ones. Among the internal environmental factors, the hospitals' managerial resource-related factors (specifically, the passion of nurses) were the most important contributing element. © 2011 The Authors. International Nursing Review © 2011 International Council of Nurses.

  4. Epidemiology of Skin Cancer: Role of Some Environmental Factors

    Energy Technology Data Exchange (ETDEWEB)

    Fabbrocini, Gabriella, E-mail: gafabbro@unina.it [Department of Systematic Pathology, Division of Dermatology, University of Naples Federico II, Naples (Italy); Triassi, Maria [Department of Preventive Medical Sciences, Division of Hygiene, University of Naples Federico II Naples (Italy); Mauriello, Maria Chiara [Department of Systematic Pathology, Division of Dermatology, University of Naples Federico II, Naples (Italy); Torre, Guglielma [Department of Preventive Medical Sciences, Division of Hygiene, University of Naples Federico II Naples (Italy); Annunziata, Maria Carmela; Vita, Valerio De; Pastore, Francesco; D’Arco, Vincenza; Monfrecola, Giuseppe [Department of Systematic Pathology, Division of Dermatology, University of Naples Federico II, Naples (Italy)

    2010-11-24

    The incidence rate of melanoma and non-melanoma skin cancer entities is dramatically increasing worldwide. Exposure to UVB radiation is known to induce basal and squamous cell skin cancer in a dose-dependent way and the depletion of stratospheric ozone has implications for increases in biologically damaging solar UVB radiation reaching the earth’s surface. In humans, arsenic is known to cause cancer of the skin, as well as cancer of the lung, bladder, liver, and kidney. Exposure to high levels of arsenic in drinking water has been recognized in some regions of the world. SCC and BCC (squamous and basal cell carcinoma) have been reported to be associated with ingestion of arsenic alone or in combination with other risk factors. The impact of changes in ambient temperature will influence people’s behavior and the time they spend outdoors. Higher temperatures accompanying climate change may lead, among many other effects, to increasing incidence of skin cancer.

  5. Perinatal and Early Childhood Environmental Factors Influencing Allergic Asthma Immunopathogenesis

    Science.gov (United States)

    Gaffin, Jonathan M.; Kanchongkittiphon, Watcharoot; Phipatanakul, Wanda

    2014-01-01

    Background The prevalence of asthma has increased dramatically over the past several decades. While hereditary factors are highly important, the rapid rise outstrips the pace of genomic variation. Great emphasis has been placed on potential modifiable early life exposures leading to childhood asthma. Methods We reviewed the recent medical literature for important studies discussing the role of the perinatal and early childhood exposures and the inception of childhood asthma. Results and Discussion Early life exposure to allergens (House dust mite (HDM), furred pets, cockroach, rodent and mold)air pollution (nitrogen dioxide (NO2), ozone (O3), volatile organic compounds (VOCs), and particulate matter (PM)) and viral respiratory tract infections (Respiratory syncytial virus (RSV) and human rhinovirus (hRV)) have been implicated in the development of asthma in high risk children. Conversely, exposure to microbial diversity in the perinatal period may diminish the development of atopy and asthma symptoms. PMID:24952205

  6. Epidemiology of Skin Cancer: Role of Some Environmental Factors

    International Nuclear Information System (INIS)

    Fabbrocini, Gabriella; Triassi, Maria; Mauriello, Maria Chiara; Torre, Guglielma; Annunziata, Maria Carmela; Vita, Valerio De; Pastore, Francesco; D’Arco, Vincenza; Monfrecola, Giuseppe

    2010-01-01

    The incidence rate of melanoma and non-melanoma skin cancer entities is dramatically increasing worldwide. Exposure to UVB radiation is known to induce basal and squamous cell skin cancer in a dose-dependent way and the depletion of stratospheric ozone has implications for increases in biologically damaging solar UVB radiation reaching the earth’s surface. In humans, arsenic is known to cause cancer of the skin, as well as cancer of the lung, bladder, liver, and kidney. Exposure to high levels of arsenic in drinking water has been recognized in some regions of the world. SCC and BCC (squamous and basal cell carcinoma) have been reported to be associated with ingestion of arsenic alone or in combination with other risk factors. The impact of changes in ambient temperature will influence people’s behavior and the time they spend outdoors. Higher temperatures accompanying climate change may lead, among many other effects, to increasing incidence of skin cancer

  7. Maternal exposure to an environmentally relevant dose of triclocarban results in perinatal exposure and potential alterations in offspring development in the mouse model.

    Directory of Open Access Journals (Sweden)

    Heather A Enright

    Full Text Available Triclocarban (TCC is among the top 10 most commonly detected wastewater contaminants in both concentration and frequency. Its presence in water, as well as its propensity to bioaccumulate, has raised numerous questions about potential endocrine and developmental effects. Here, we investigated whether exposure to an environmentally relevant concentration of TCC could result in transfer from mother to offspring in CD-1 mice during gestation and lactation using accelerator mass spectrometry (AMS. 14C-TCC (100 nM was administered to dams through drinking water up to gestation day 18, or from birth to post-natal day 10. AMS was used to quantify 14C-concentrations in offspring and dams after exposure. We demonstrated that TCC does effectively transfer from mother to offspring, both trans-placentally and via lactation. TCC-related compounds were detected in the tissues of offspring with significantly higher concentrations in the brain, heart and fat. In addition to transfer from mother to offspri